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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XFW2</accession>
    <name>A0A8B7XFW2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110973281</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110973281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079664.1">
        <property type="nucleotide sequence ID" value="XM_022223972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XFW2"/>
    <dbReference type="GeneID" id="110973281"/>
    <dbReference type="KEGG" id="aplc:110973281"/>
    <dbReference type="OMA" id="AIMRISW"/>
    <dbReference type="OrthoDB" id="425014at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47027:SF20">
        <property type="entry name" value="REVERSE TRANSCRIPTASE-LIKE PROTEIN WITH RNA-DIRECTED DNA POLYMERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022079664.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29727" checksum="955ECDD4FC0D0BA1" modified="2022-01-19" version="1">MTHDPVHIAAFYYQLKDVLQNTPSTDTVVVFGDFNARANATKMYNQEPPRLGLTIHTRKTKVMLLPHRHTVYADPELSLDGNQLQDFKLCTALPTSAEQSNSLDKEVERSISAATTACGKLQSKIWKKHYTWLTTKCKVYRAVVLTCLLYSSKTYILYRRHKRLQLVYMYQLRHLLKIHWQDRISDVEVRRRTGIPSVAALLKQSRLQWSSHVVRMEDSWLPKAVFFVANDAPTMNDTVEVVILQEREGVGGDRDVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XI58</accession>
    <name>A0A8B7XI58_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110973733</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080478.1">
        <property type="nucleotide sequence ID" value="XM_022224786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XI58"/>
    <dbReference type="GeneID" id="110973733"/>
    <dbReference type="KEGG" id="aplc:110973733"/>
    <dbReference type="OMA" id="HKKTRIN"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000020">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="9"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="14">
        <location>
            <begin position="91"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022080478.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13531" checksum="17A05BE5193279E8" modified="2022-01-19" version="1">MSGRGKGGKSRAKAKSRSARAGLQFPVGRVHRFLRKGNYAERVGAGAPVYLAAVMEYLAAEILELAGNAARDNKKTRINPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAVLLPKKTSSKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIC4</accession>
    <name>A0A8B7XIC4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110973427</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 13">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the complex I NDUFA10 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079961.1">
        <property type="nucleotide sequence ID" value="XM_022224269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIC4"/>
    <dbReference type="GeneID" id="110973427"/>
    <dbReference type="KEGG" id="aplc:110973427"/>
    <dbReference type="OMA" id="DPHNKKM"/>
    <dbReference type="OrthoDB" id="17400at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015828">
        <property type="entry name" value="NDUFA10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF15">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000543">
        <property type="entry name" value="NADH_UQ_42KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="14">
        <location>
            <begin position="71"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022079961.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="43583" checksum="68B50448C6D5C1BE" modified="2022-01-19" version="1">MVFHICRMGMRQGAHLKLSAAKLCGLTLAPKMAPCMQVSYRGMFVSTDNLITFFTGHKFMHKFDERSKIVVVDGNIGCGKSKFSQELAAKLGMKYMPEAHVHYLDELELGPGKKYDPKYIGNVSLERFYKDPFDKDGHSFRFQMMMYAMRFRQYADVLEHLLKTGQGLVMERSVYSDYIFMEAMFKMGYFRKACYDYYNEIKGISLYRLRPPHLVIYLDAPVDVLQKRIKERGKETEAEIPSEYLQHIEDGYKNRFLPQISETSEVLRYDWTDYGDIDLVVDEIQMLKFEHLPWNTEDDVTLDKLYRFVYNKYHVARCMDIPKYLPELTFGAQEFYDLTREFEEKYNKHYAPGYNLKEGEPKWKLFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XL17</accession>
    <name>A0A8B7XL17_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hyaluronidase</fullName>
            <ecNumber evidence="3">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022080852.1">
        <property type="nucleotide sequence ID" value="XM_022225160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XL17"/>
    <dbReference type="GeneID" id="110973932"/>
    <dbReference type="KEGG" id="aplc:110973932"/>
    <dbReference type="OrthoDB" id="5796153at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF35">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080852.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="55845" checksum="798B75250DE7BAE9" modified="2022-01-19" version="1">MGRDFGGVSVVPVQGAQELIMHGLGLQIIQTGLDPDQHFRRGKLIISSRLKYCAQGERRMPETRIFAQGLLFTLTVLSIPMVSSLKSASQQSDLFGIPDAQSQQLVSGRQSSPSSAPPALADCAFTAVWNIKNSQRCHAKFGVDLNLASYGIKTNSLTGKGVLAYFSHENLGRLPYIQHGKFVNGGLPQLVNMTAHLEKAAGDILAAIPDANYSGLGVIDWEFWSPAWNKNMHSAKVYVTESIDLVRLRHPTWDLATVEAAAKTEFEEAARSLFEGTILLARRLRPKALFGFYHFPYCQNRDDARHCKPLTLASNDELLWLADASSALYPSIYMKQKNIRASSAVYIETILQEALRVRNSSRSPTLPIYSYCALNYTFSGYYLNLEDLRNSILLSAEQGLAGVVFWGDNNDTSNRAACLDLQGYIKAALGPLVQKTTKAAARCSAALCSGHGRCVGKILECVPKGVQALSRTPSRVTGSANVTFVEKMPSECRCQCYEGWNGDNCDHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMJ1</accession>
    <name>A0A8B7XMJ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein mago nashi homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110974588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082028.1">
        <property type="nucleotide sequence ID" value="XM_022226336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMJ1"/>
    <dbReference type="GeneID" id="110974588"/>
    <dbReference type="KEGG" id="aplc:110974588"/>
    <dbReference type="OMA" id="IRKEMWI"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022082028.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="17292" checksum="97E6A356DFDF0F4C" modified="2022-01-19" version="1">MSNGEFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKAVIEELKRIVQDSELMQEDDELWPQPDRVGRQELEIVMGNEHISFTTSKIGSLIDVGNSRDPEGLRIFYYLVQDLKCLVFSLIGLHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN73</accession>
    <name>A0A8B7XN73_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Golgi apparatus protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110974744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022082269.1">
        <property type="nucleotide sequence ID" value="XM_022226577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN73"/>
    <dbReference type="GeneID" id="110974744"/>
    <dbReference type="KEGG" id="aplc:110974744"/>
    <dbReference type="OMA" id="WTHEDRI"/>
    <dbReference type="OrthoDB" id="2015434at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017873">
        <property type="entry name" value="Cys-rich_GLG1_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51289">
        <property type="entry name" value="GLG1_C_RICH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="56"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022082269.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28785" checksum="23A126E7CDF00A52" modified="2022-01-19" version="1">MEGDFRLNPRMQKACRRDMPKFCSDVLDKFKKEEYKEKELEGEMLLCLKKKFPTKSLSPDCENYIRDAIQEASMDIRMDPVLFSGCQDTAKRLCSEELETPGQGLVAECLKTNLYKGKIISLKCRMQVIRLLQECRTDVHIDTLLYKACALDIKHFCAGIPQGEGRQMSCLLEALEDTTVNLHADCQRMLSERKEMWRYAIRESPPNSFPDLAAAINAPKARGQLLTILFLVIGVLGFGGLYCYSSRQKIQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPF8</accession>
    <name>A0A8B7XPF8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110974995</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082709.1">
        <property type="nucleotide sequence ID" value="XM_022227017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XPF8"/>
    <dbReference type="GeneID" id="110974995"/>
    <dbReference type="KEGG" id="aplc:110974995"/>
    <dbReference type="OMA" id="GRAFNTE"/>
    <dbReference type="OrthoDB" id="10443438at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022082709.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="41529" checksum="7070E27A30675387" modified="2022-01-19" version="1">MPSQTKESSLAEPQLTSAIVVDPDRPATNNATGPSPVMPSLSPYPLAGEPHLGVIAERKNAAKKMLDFGDPADTEIDEGVKAIEDGGCSTEEVVSVQGELSPRNTDAEATQVSGLTTPQALDSPGSPHIVGRAFNTEHVSLTPPPLESSTLKRHHSVSPENSRAKHLCNTSPDFSDFFPHETSTSFRQPELVADLELGDCQGQGSSLPVFSRNSLADMPFLDFHQGAEGEAGDPEDVLRCHGINLFENPAHREELINFCQQSLAHSNEHAGDLNSNNNKADLCEGHDYQCQTAHDKLASVIQRARSKGFLVSDAMYFDGKQYVPIKVATNGRGKFRLLLPPDHPHRKGVAEEIPIFTTFEIDSSEDAFTQDDEEGSEQSHESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPW1</accession>
    <name>A0A8B7XPW1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">DNA damage-regulated autophagy modulator protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12 13" type="primary">LOC110975061</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082857.1">
        <property type="nucleotide sequence ID" value="XM_022227165.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082858.1">
        <property type="nucleotide sequence ID" value="XM_022227166.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082859.1">
        <property type="nucleotide sequence ID" value="XM_022227167.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082860.1">
        <property type="nucleotide sequence ID" value="XM_022227168.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082862.1">
        <property type="nucleotide sequence ID" value="XM_022227170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XPW1"/>
    <dbReference type="GeneID" id="110975061"/>
    <dbReference type="KEGG" id="aplc:110975061"/>
    <dbReference type="OMA" id="TAYVRYH"/>
    <dbReference type="OrthoDB" id="191706at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022082858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022082859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022082860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022082862.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34206" checksum="8B269BE493681E26" modified="2022-01-19" version="1">MPCGLAWLPILSSVTSLGTIIVTYTLAAVNEHIFLVLPYISDTGVHYPESSLFSLFLDVSAAFFLLTAYVRYHHVRQFQDRFQENRLWRFRRVNIAGLMVSLVAAVGLIVLANFPEDEDLLIHLLGAFFCFTFGVAYCLLHAWLSFKTSPTPSPTWVCIIRLVLGCLGIIHTSLVILFGTVLRWHADSCNPQMKFRRISAMFEWLLVVTFNLYTLTFTYEFRHIQLATILRHWTGDSWEFMELPADEVTASSGVASGSEAAKLQLEEEANGNQPARYPCLHLDGSLHTVTVCETCNAEGKAHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQG5</accession>
    <name>A0A8B7XQG5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">N-acetyltransferase 6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110975167</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083065.1">
        <property type="nucleotide sequence ID" value="XM_022227373.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083066.1">
        <property type="nucleotide sequence ID" value="XM_022227374.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083068.1">
        <property type="nucleotide sequence ID" value="XM_022227376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQG5"/>
    <dbReference type="GeneID" id="110975167"/>
    <dbReference type="KEGG" id="aplc:110975167"/>
    <dbReference type="OMA" id="SANEKFW"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905502">
        <property type="term" value="F:acetyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039840">
        <property type="entry name" value="NAA80"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538">
        <property type="entry name" value="N-ACETYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13538:SF4">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083068.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="29153" checksum="205E6F5C39FFDB82" modified="2022-01-19" version="1">MMDSTVGIHMEPLHKRPDLMDACIDLLNAQWPRSKAARLHSLDKSCDSLPYSLVMVDDKREIGSDPSAVIGYCRLAKVISVPSSVLIESVVVPKNLRGQGLGRQLMELAETHAKMQGFTTMYLSTKDKQDFYAHLGYEFCKAVNTLDAQILETCDLWQVDCDSTSLSHVSCSSESECPSRDEHPSAGRRQVSRLDGGCPKAVEDSSDDSCSKPSPDSKTSGSLPMSQSGDGAPCETNLSIPPPPPPPPVRVPETPPMVVYWMKKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRM7</accession>
    <name>A0A8B7XRM7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110974970</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082655.1">
        <property type="nucleotide sequence ID" value="XM_022226963.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974970"/>
    <dbReference type="KEGG" id="aplc:110974970"/>
    <dbReference type="OMA" id="QWEPVMA"/>
    <dbReference type="OrthoDB" id="10066368at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055123">
        <property type="term" value="P:digestive system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048732">
        <property type="term" value="P:gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000279">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000045">
        <property type="entry name" value="Slit guidance ligand 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000018">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000002">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="3399" mass="363393" checksum="40D33C66D92F14B1" modified="2022-01-19" version="1">MAWKKTLFVSLLLVVLLCTFDQADAFWWGRRRRRRSPPPPPAPRFSYCPSSMTNTTDNANGRRVVAYSIPRAPGFTVRRTCGPASGSVFDEGVHTITHEARNSAGQRAYCTFKVTVTVLRCPNIPSSSHRMFSCTKSVISGSECTFSCRHGYRLVGSNSLTCQNNERWTNDFPTCQARTCSPRQTSIPDGNVSCSDSNLFGSVCTFACNRGFGFQPGDTATRTCGSTWSGSVPTCIELSCPPLAAPPHGRFRQPCDNTFGSWCYLVCEEGYSVAGSASRRCTESETWDGTPTECRINMCQKLTPGPGLQVVPVYTCPAGNSVPYNSICCYTCEDGHIMHGASALVCGADGSWLQTLPVCQEITCSSNDLPAPVNGMKSGCSGQRIPYGTTCTLSCNHGYTPTTTTQRTCQRDISNLGVWSGGTITCTAVTCPPLANPPNGFISTCVRNGQESAVRDRQQFDTACTVACDSGYTLRGTNTLTCVVSGAWTGTSLECTDETNPVVQCPLDQVIFAGEGQSRVSISWQWEPVMARDAGSDIPAILQSIDSNPFSAPRPTSLGEGIHLLVYSATDASGNTGSCVMRIEAKVARCPGLNAPTNGAIQLVAGQGSCAQGAVHGSQCEITCSVGHVLSTGGATLRRQCNRTSDQSSQGYWSLEQPTCEANSCPHPVIANGYITGCQGSAASYGESCEFRCDPGRRSASGHTRLSRECQADGSWSGTDFQCTEMVTCPGPFSVTNGSVEPALCRQDRALPYGTVCRFSCANGFRLQGPTNNTCSATGAWDNPHSTVCLDTQSPSFDSSCPLSVVERSDNGSTSAIVNFDAPTATDNSGSVTVNRRSGHPAPGSRFPEGMTTVTFYAIDPSGNTAHCDVTVTVTVNRCQMLSAPAFGSIRCSFASPVVGTECNFTCNRGYTLSGSTTATCRLTGNGMRSWDGQTPACTIVQCPSQPTPPNAVQLGCSSDLSSAETFGTECFFYCQSGYRALSSDGGRARCLENGTWSGTDLVCTETECPTLSPRDRVTLTPAACNNRPVFGQNCYLSCPGSGYEIDPRGSDYITCLNNGDWSRNISNTTCVDWQEPRWATRPPIVIVHLEIGQTAAHVNWNITATDNSGTPPSVTCSPGPGQFYRGDHLVMCTATDTAGNQALHHFEVKVQGWYTHKENTQSDRSSYKRILTVAINPLYYLVSCDSLMLPNGMQVVPQICAFGSPPAGTLCTVLCLYGFVPSGGSVLSVRCGQQGLWEGGLANLPTSCEDQAAPFLTYCPGPVYANLTDPAGALVSFDTPTAQDNGLPGTLSLVISPPNITSPYLFTESTVVSFTFIDTANNSVTCMFSVHLLDEREPEVIFCPSDGYRVIAVARITEFTWEEPRFRDPSGDNLLITNNRGQGNTFDFPVGTHMVIYVALDPDSGKVATCQFTVVVEYAPCLPLNTPANGALACDSLGRFCAFHCNDQFMVLRTSSHEPGDDFECRPDGTWHPPADELPDCSETRNPFLTDLKANLKYFTGDCTNQSTMESIAAAFIMVLEDSGSLEECNQHINCTVQNVQVHCGPRSRRRRSVDLPQRGDVHRGRWQRSAHAPPTGSRRRRRRTTVSWEATISFDIRAPFLPATNVSSRAVVLEAEAAMMRAADRLFYRMLNGSIPPLQVPGLDVELDETSLGYRYAEVLCEQGYIPDNDAYVCAACTAGTMYNASTVECQLCPRGSYQEEQAQLTCIPCPPGTTTAAEGTKNATSCREICSAGRFSDNGITPCTRCMMGRYQAQRGQTSCQTCPEGTTTLDFGAQSVDQCLELCPPGSMSDTGLAPCRPCEHRTYQPRSQQRHCIVCPGNGTTLGEGSTSVDQCIDVNECESSPCPQEAACVDLIDGYRCECLPGYEGVTCQNVDDCRNHLCINGATCTDGLMSYVCVCDPAYEGTHCEINVDECVSAPCQNGGSCLDGIGEYLCQCAPDYHGIHCEQERTSCSPSPCQNGGTCEVVGARYQCRCSPGFSGTDCEVDIDECISNPCFNGGTCNDLPNGYSCTCLAGYTGRLCQTVIDWCAESPCHEGATCVDQGRFFRCVCPQHRSGPLCDRTPCQNSGLFLEGLTELYTCRCPAGYEGQNCEIDVDECASGPCSNGATCRQHQVNAFMCECPPGFQGDLCTIDINECASSPCGNGSACEDDINGYTCLCGPGMTGARCQDPVDFCVQSACQHGATCLSIGTGYQCLCGAGFTGPDCQLDVNECLSGPCMNGGSCANHVGGFTCTCLGDYVGSLCEVHRSDCSFDCQNGGTCLDGVTGFYCVCLNGFTGAHCQVNLLNSCSSQPCQHQGTCLAGPSGYQCQCLPGYTGPNCEVDVDHCASVPCLHATACLDGVATYTCFCESGFSGANCDVDIDECASRPCLHGGVCQDLVAGFFCLCPEGFNGTLCQGIVPHCGGDPCFNGGVCVDVNDTFRCLCNQGSTGQFCEINLDDCNPDPCLNGAKCSDGLNAYTCQCLPGYSGANCELEINECQQSNVQCQHGGSCVDKVGDFECSCVAGYGGRYCEAETDECESNPCQNGGSCQDEFASFSCDCPLGFTGAQCDIEVNLCLNGPCRNGASCIPRAGNFTCVCPAGLSGSLCDSEIDECSSQPCRNQGRCIDQMNGYQCECLPGYTGTHCGGEYSTDFDLKFSSPVSGTDLVRAVNLTSGHLPELSALLWLRSSNCHGDLTLLLLSVPGGPSIRLSRPSNLTLTFLGFSLNSFHQTPASGMASTLCDGRWHSVLLTWRALGPRQEWATYVDQSLASEGSLSTSSLGLPAGLSLIIGPQTEDAVDDGVEPFELELSGVNIWSRALSEAEIADIASSCRPTSSLADVFAWGQILIIASDGITHTLKTPSECDDFDECSSNPCLAGLCEDRVKGFACHCYPGWEGDQCQTKVDYCRPDSCLNRGECRSENISYSCSCPRGFSGKRCELEVVNGGWGPWSPFSDCSKTCGGGRQYRIRTCDSPQPLNGGRACPGEDQQLLPCNNGSCPTCINLRPPLKGVLHCNRTESNESRCQIACKPGYAFDREPYKDYQCGKSTSYAWNHQSVGNPYAKLPSCVEAMNPIGTAAAVTANLSQVTCNSASQQDAISMSISQNPAVTNRDCVADRSCSFRVNVANCKYSTGRAPRQTESNVQIQIAFFTNTTGNSSGPGGGDENDVTLQAAETLRTLMQVGGFMLEVKGQVVQPDPDSVELDWGSICPNGSVESPGGYCVRCGPGTFLFESQVEQDTECQPCPANTYQDQEGQRQCKACPGGMATDGKGASSTSECYTQCNAGMYRVRGDVITDSHCELCPRNTYSPTRGMDFCLLCPPDTVTKETGASRETACQEPVASTEIPTQTTPPDGPNDSLSAIIGVSVAVIVLAVFITGFCWYYIARRRPDVSQRSQQPTIPLNSVEHNYANVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XS88</accession>
    <name>A0A8B7XS88_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">39S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110975160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083057.1">
        <property type="nucleotide sequence ID" value="XM_022227365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XS88"/>
    <dbReference type="GeneID" id="110975160"/>
    <dbReference type="KEGG" id="aplc:110975160"/>
    <dbReference type="CTD" id="51073"/>
    <dbReference type="OMA" id="WIENTDA"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000005">
        <property type="entry name" value="39S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_uL4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022083057.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38526" checksum="330F9662AB180D88" modified="2022-01-19" version="1">MVTTMLSRFARVSRLCSCSAFRNFSEPSRIRNSRKSLFTTAACLQQSDQGTSKGENFIHVVSTEFENPDRWQNLPLVTGRSVDAPAFLEKPQAWLETISTLENIKLGMVDLHPEVFATMPRIDILYQNVLWQRDYKRISLAKTKSRAEVRGGGRKPWRQKGTGRARHGSIRSPIWRGGGRAKGPRGPRSFWYELPVSIRAQGLRVSLTVKLAQDNLHIVDSLELPSAEPQFLEDVGLKRHWGGSVLFVDNKPVPEMPENFLQAVSGIKTYNVLSTEGINVYSMLKHHTLVLTLDAAEFLEQRLLFYMRCYRKRDIIDTHKIQLGQLKILPSKRVTSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUA4</accession>
    <name>A0A8B7XUA4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein smoothened</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 25" type="primary">LOC110975362</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083496.1">
        <property type="nucleotide sequence ID" value="XM_022227804.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083498.1">
        <property type="nucleotide sequence ID" value="XM_022227806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUA4"/>
    <dbReference type="GeneID" id="110975362"/>
    <dbReference type="KEGG" id="aplc:110975362"/>
    <dbReference type="CTD" id="6608"/>
    <dbReference type="OMA" id="WLAYAWH"/>
    <dbReference type="OrthoDB" id="10064659at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005113">
        <property type="term" value="F:patched binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071679">
        <property type="term" value="P:commissural neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15030">
        <property type="entry name" value="7tmF_SMO_homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000068">
        <property type="entry name" value="Smoothened, frizzled class receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035683">
        <property type="entry name" value="SMO_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF35">
        <property type="entry name" value="PROTEIN SMOOTHENED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665473" description="Protein smoothened" evidence="20">
        <location>
            <begin position="30"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="21">
        <location>
            <begin position="44"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="22">
        <location>
            <begin position="209"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="622"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022083496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022083498.1"/>
        </source>
    </evidence>
    <sequence length="778" mass="86391" checksum="F4FD2E14006CB930" modified="2022-01-19" version="1">MAQIKERVALCWVVTFVTAWAWMLPQVGAVNRTVFDSLGVPSCQRQATCIPVLNATCLGSAIQHSQTSLDLANDSATSAEALRNLQKWEGLRLVPKCWEVVQPFLCAVYLPHCEDGLVELPSYDMCSVTRGPCRIVDIEHGWPEFVTCSEDRFPPSCDNVYKSITFNTTGECEPPLVATENEKSWYDTVEGCGIQCRNPLYTDEEHAQVHLFIAVFASVCVVCTFFTLITFCADWKNSSKYPALILFYMNGCFFAGSIGFLAQFPSGARDDIICRKDGTMRLAEPSEGENLSCTIIFILVYYFIIAGVIWFVWLAYAWHLSFRALGTPRQALKGKTSYFHLLAWSLPFILVVIIVAINQVDGDSVSGICFVGYQNHYYRAGFVLLPIGVMLLVGGFFLTSGLKTLCTIDRDNPGLLSDKAAHRIKGTIVRIGVFAALAFLFVFITFACHLYEFTNQESWRQGFQDYLVCEANVTFLSGLSDKPVPTCSLNSRPNISVIMVHLFSMFGAGIAMSMWVWTPSSLAIWQRTWRKITRQAINEPQRLKKSRMIAKAFAKKMDKKREENDDAMSVSFESASHDDAIGMKLDLPKSSVTEDSSSIWGKGNNVPARMLMRRGGGALPLPVFATNASSPRNSPDSQLASRPGTAATAGRNLVQAEVVIEPPPPNMRKTRRKKRRDRSHRRAQLLPLRGPSGRETPMDDRFILGDDIEDIPSNGGETIGRRARNSIPGEIPDLPGNGLPRGSSVPKLPEIQRRRQVSIIAPPVDYDLPSSLSIDSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUE4</accession>
    <name>A0A8B7XUE4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110975904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084468.1">
        <property type="nucleotide sequence ID" value="XM_022228776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUE4"/>
    <dbReference type="GeneID" id="110975904"/>
    <dbReference type="KEGG" id="aplc:110975904"/>
    <dbReference type="OMA" id="RNRTIMA"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000036">
        <property type="entry name" value="septin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="48"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022084468.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="49548" checksum="CF15AF2B68D80157" modified="2022-01-19" version="1">MTMESDNHAPTDDRQNSVDDARSRDLRLSGHVGFDSLPDQLVNKSVAQGFSFNILCVGETGLGKSTLMDTLFNTQFESSQAPHNLPGVKLNASTYELQESQVRLKLTVVNTVGFGDQINKEDSYKPIVEYIDKQFENFLQEELKIKRALHSYHDTRIHACLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPVIAKADTISKSELHKFKIKIMSELVSNGVQIYQFPTDDETVSDLNSTMNGHLPFAVVGSTEEVKMGNKMVRARQYPWGVVQVENENHCDFVKLREMLIRTNMEDLIEQTHTRHYELYRRCKLEEMGFVDTSPENKPISLQQTYEAKRTEHLQMLQQKEDEMRQIFVVRVKEKESQLKHMEKELHERFDKLKRDHADEKKQLDEQRRQLEDEINSFNRKKQQAQEDSQQAQTLGKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW33</accession>
    <name>A0A8B7XW33_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110975777</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084245.1">
        <property type="nucleotide sequence ID" value="XM_022228553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XW33"/>
    <dbReference type="GeneID" id="110975777"/>
    <dbReference type="KEGG" id="aplc:110975777"/>
    <dbReference type="OMA" id="MTRWILA"/>
    <dbReference type="OrthoDB" id="10019596at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034480860" evidence="1">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084245.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14897" checksum="2B125FC2AA50FBC6" modified="2022-01-19" version="1">MTRWIVTLLLGVCVTVVLASDTGADDDKVHIDDATCQALANQVKAERGRRWPWSRTGPKHYFCQPTLEKKKEAYCNCKVVPRKRDDGDQSEFLKPEKAGSFLESSIGKRDFNHECCKEGCYWEEVEEQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XX89</accession>
    <name>A0A8B7XX89_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110976491</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110976491</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085494.1">
        <property type="nucleotide sequence ID" value="XM_022229802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XX89"/>
    <dbReference type="GeneID" id="110976491"/>
    <dbReference type="KEGG" id="aplc:110976491"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="370"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="658"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="786"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="808"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="826"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022085494.1"/>
        </source>
    </evidence>
    <sequence length="862" mass="95540" checksum="3665C549C3F424B1" modified="2022-01-19" version="1">MSGVITSYRDVQPECALCSGRTLLSESKRLYCAHTYCLKCLKGLVMLDDIPPKNPVVGCPLCLTLTPIHSPEIACQSTVFDLQSLLDALPPLVQPESPAEVAKTEDSESYMCEIHEEIEPDTPAEVAETDDGEPYEIHEEWDPETLAEVAKTEESESYMCEIYEKIEPDTPAEVAETDDGEPYEIHEEWEPETLAEVAKTEESESYMCEIYEKIEPDTRAKVAETEDGEPYMCEIYEEWEPETLAEVTETEDGERMCETCGEVEPEATAEVTETEDGEPYEIHEEWEPETPAEVTETEDLEPYEIYEEWEPETLAEVTETEDGERMCETYGEVEPEATAEVTETEDGEPYEIHEEWEPETPAEVTETEDGEPPVCEIHNEVKKFYCCSCEVLICRDCTVVDHPRPQHKCMNLDEACTWRCALNERELQTAVRVVKQVNRSGGILKSTEVALNQRCDQVITEIERCREMGLEQLQWHVEAIEAFQMDLEAEIFGLHDLTEDATKKDLLEQSTELVESLMSLCEQQEEVINKPQPVQYPAFLESVDEIQGWPKPLNLDGLDEEEPDLPTPEGQQSLESKDQSNKDTDSTSRVRIPPVADAGPVVVDSSSRKDSLGGRSEKNHQPRVRTLQSSRSNDPPKIERGNTSRLVSPLKIPWPLFGVGTANRQPRQRLQQNTRSGTTSRRLQAYQTMAPPRGFDCQRQDSPGGRGKESRGRGQYHHSARGGANNYGRGGADNRGRGGADHRGHFGADHRGRGGSNNRSKSGADNRGRGGADNRGGGGASHRGHGGADHHGRGGTDNRGGGGASHRGRGEADHRGRGGADNRGRGGAHHRGRGGHQQHGRGGKQGQGGGKQGQGSGRQKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXE2</accession>
    <name>A0A8B7XXE2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monocarboxylate transporter 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084927.1">
        <property type="nucleotide sequence ID" value="XM_022229235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXE2"/>
    <dbReference type="GeneID" id="110976173"/>
    <dbReference type="KEGG" id="aplc:110976173"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022084927.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="38746" checksum="341F13863724922B" modified="2022-01-19" version="1">MCFSSAVTIISDSFHKHFSVVFGIACSGGSVGVVTLPVVSGFLIDHYGWRGALLLISAIQVNILVCAKFMKPTPCGQTSANLVDSGGKGYGSLENQLSRETDSVKDETEVDSESKDSLSWHQSRSSCGVNAQYEDNNLAKDMKWMEKLVQFLDRTGVSLIWTNRVFASFLLLPIPTSVGDAVSLLFLVARAESVGIPGLQAEVLLSLVGVANIVGCCASGPLVNANVAELAFIYCLFEAVVSISAMGVAVLESYAFFVAYAALYGFSSGVYIPLGGITVRRIVGQERFPGGFGIALVLVASGNMLAGSVSGHLYDTTKSYSSCFYVLGAAAGLCAVLSLGLHLLWTRLIPDDRWPSIVRLPLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXK1</accession>
    <name>A0A8B7XXK1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dipeptidyl-peptidase IV</fullName>
            <ecNumber evidence="3">3.4.14.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC110976541</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9B family. DPPIV subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022085596.1">
        <property type="nucleotide sequence ID" value="XM_022229904.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085604.1">
        <property type="nucleotide sequence ID" value="XM_022229912.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085614.1">
        <property type="nucleotide sequence ID" value="XM_022229922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXK1"/>
    <dbReference type="GeneID" id="110976541"/>
    <dbReference type="KEGG" id="aplc:110976541"/>
    <dbReference type="OMA" id="VTHMTPQ"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.140.10.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 8-like isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000016">
        <property type="entry name" value="Dipeptidyl peptidase 8-like isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045785">
        <property type="entry name" value="Dpp_8/9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF193">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19520">
        <property type="entry name" value="Dpp_8_9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Dipeptidyl peptidase 8 /9 ,N-terminal" evidence="11">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="10">
        <location>
            <begin position="177"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="9">
        <location>
            <begin position="648"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF19520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022085596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022085604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022085614.1"/>
        </source>
    </evidence>
    <sequence length="848" mass="95207" checksum="9A6084F454D1D482" modified="2022-01-19" version="1">MATGPTATSMPDSALSQPQHSSRSEIKHSWYDLHCTVKATRRLQTTLSNRVPSEFTFQTVQTVEGVRTRLYFLGVPPGNRENTLLYSDLPDDAGLAADTVPVEQLPWNPLLVPFRGLNHMGFSKEEQLLRERKRLGMYGITTYEFDPESGKFLFPANGSLFTCHDPMLTNQPVFPREVVSQCQGVRMDPKFCPFNSGLVSFINNSDLWVTNTNTGEEKRLTFAHKGLQNIAKDPKSAGVATYIVQEEFDRYTGYWWQPQPTDLVPGTGKTTFRILYEEVDESEVEILHIVNSSYGEHGVDDYRYPRSGTTNSKVILKLVEFSVDTEGKIVDVTDKQLSEPLTKHFPWLEYIVRVGWTPDGNNMWAQLLNRNQQSTAVILIPLQSFLPVCSDAEMRESSDGSESLIRVLYEEHSDLWINVHDAIHFFPQTLPGEISFLWASEATGIRQLYFITSALQQPGAIPGNLKPAILQYKMLTSGKGEVIGQQLWVDEISQLVYYKALHDTPLEEHMYVVSYRNPSPPVRLTELGYNVQTVVLSPDQRYMACVLSSLTTPPFSSIFRLSMMGSQPLGMEAKPVCSLLPASAAPATCIPPELFSYTSAATGEAMYGLLYRPHSTDPSRPHPTVLFVYGGPQIQLVTNSYKGIRLLRLQTLASLGYAVVVVDSRGSSRRGLKFEGVLKNQLGSIEIEDQVEGLHYIAAKTGIIDLTRVAIHGWSYGGYLSLVGLAKKPDVFKLAIAGAPVTCWREYDTGYTERYMDTPLNNPAGYAAGSVLNMARNFPDEENRLLIVHGLIDENVHFVHTSLLVDELIKHCKPYQLQIYPRERHGIRRPEASEHYETQLLSWLQAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYF4</accession>
    <name>A0A8B7XYF4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110976105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110976105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084806.1">
        <property type="nucleotide sequence ID" value="XM_022229114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYF4"/>
    <dbReference type="GeneID" id="110976105"/>
    <dbReference type="KEGG" id="aplc:110976105"/>
    <dbReference type="OMA" id="EDAGICE"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF26">
        <property type="entry name" value="RE23625P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="186"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022084806.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="36563" checksum="AED80E52A2228E2E" modified="2022-01-19" version="1">MAPSEKKKGSPLDCKSHRDRHHHHRHHHPPPLGHAPPLAGHPPHPGFLGPPGFAEDWDPHFPPHRHFPGGPAHHFRFEPGPYGPGRWPGDPRRHWWDGSSDDEEATGAPWWWADEGDCPERRHPPRPGDRRGRGGFWHRGLGLGFGRRMWGPPGGFGRGGFGPAVGFGRGPLPHGFDLISHLPAHPWDGDSDSTSSEDEAESDFEATFHLGQYKKKNISVRLAGRHLLVEAKARERQGSRGRKGSCRRYFAEQRILPKTADWCRMTASLSLDGLLTIRAPPRAGEANENAGNCDRIVQVRDERSADAELEEQMNSDGDAHDQDSARDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZE1</accession>
    <name>A0A8B7XZE1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synaptic vesicle 2-related protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110976889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022086274.1">
        <property type="nucleotide sequence ID" value="XM_022230582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZE1"/>
    <dbReference type="GeneID" id="110976889"/>
    <dbReference type="KEGG" id="aplc:110976889"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086274.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19562" checksum="04F7FF44CBD02C7D" modified="2022-01-19" version="1">MASESTARLRGKKDEKVPLKKSTATTPSLAGPLEEAETALGMLEYGSNSTPKTATETETDSGDYSVNDAIDAIGVGCLQITILITSFLAMLAVFAQILLSTTINEILRCTLKLSDDKVALISTMLFVGELLGTYPISKFLDHFGRRPVSQPSMMKIFLRFKLIDVYACGCLPIGSADSLMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZY8</accession>
    <name>A0A8B7XZY8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C17orf98-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086463.1">
        <property type="nucleotide sequence ID" value="XM_022230771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZY8"/>
    <dbReference type="GeneID" id="110977011"/>
    <dbReference type="KEGG" id="aplc:110977011"/>
    <dbReference type="OMA" id="QKEFILD"/>
    <dbReference type="OrthoDB" id="9935043at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028027">
        <property type="entry name" value="SPMAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34221:SF4">
        <property type="entry name" value="CHROMOSOME LG9 OPEN READING FRAME, HUMAN C17ORF98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34221">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC691189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15075">
        <property type="entry name" value="SPMAP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086463.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22912" checksum="CA828655CBB2B87B" modified="2022-01-19" version="1">MSDEAEVPIETTPLATPGSPLTATEKPDKAVGNKSAKKSPRNKPAKSPRGPPELTHEELAEKEKNFLLDCIAVDSIAKDYSHCQPKLGPAIPPYNSQKDKHVKVYFAREQVDETLRKTKQDKGGCSIDGPVIDRFIESGAGYRYLHARNAAPGSAKAGHSTEQVNGHGQFLSDAKPIFGFNGEYGYRRNTPWLRKMPSPFGIDPRSPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0M1</accession>
    <name>A0A8B7Y0M1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitotic-spindle organizing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110976499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085516.1">
        <property type="nucleotide sequence ID" value="XM_022229824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0M1"/>
    <dbReference type="GeneID" id="110976499"/>
    <dbReference type="KEGG" id="aplc:110976499"/>
    <dbReference type="OMA" id="LSICVGM"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022085516.1"/>
        </source>
    </evidence>
    <sequence length="76" mass="8105" checksum="8FD46FDEA04D2C4D" modified="2022-01-19" version="1">MTHGKADDESVYSAREVMDTVSEMSKLLETGLDSETLAIAVKLCELGVNPEALASVIQELRREMAAYNAGGGDSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4M8</accession>
    <name>A0A8B7Y4M8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline-rich protein 36-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110977209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_022231124.1"/>
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    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:receptor complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
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        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="832"/>
            <end position="1055"/>
        </location>
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        <location>
            <begin position="241"/>
            <end position="337"/>
        </location>
    </feature>
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        <location>
            <begin position="350"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="497"/>
        </location>
    </feature>
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        <location>
            <begin position="534"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="803"/>
        </location>
    </feature>
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        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="398"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="467"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
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        <location>
            <begin position="793"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086816.1"/>
        </source>
    </evidence>
    <sequence length="1055" mass="113719" checksum="ABBDE0C97BDACCC7" modified="2022-01-19" version="1">MMPRLLFLHTLTGMIASLHLPLFPRLLIPLQFLQSPTGRISAHLSLPPKMIATVQPPAIRLMSSLQLFLLLKLLALLHCCQPMTAMSGYLSLFRKLMIAIPALIGMMESSHLHFQLSLMIPCFLPKPLTETMVSPHLPLLTLMMPPQMVLPSTGIITTLPSHPPSLVTPLCFPKPPTELIVFHLLSLLPKMLMPYYLRNTRTMMMVFPLLFPAEEDNASSQVPPINNENDGINSSITVTEADDQLPPSHSGNLGFPSPVPPAEVDNATQLATPTRDQEMLSPEHSPDDDTDPCTPSARISQNGSATPPVPPLASSTTRVDEINSTSPPTPPVADDAGALHRSAGDEVAISQVASPESSDTSIPQSSGEGRIFTSPNTDESATVTPPSSSDNHIDNQQVAPRPESTLRAEIMERVRAMMAQSPGNGVSDASEPLWMQAMRAAQQTSPEAHLQARQRSPSPIVPSTSANPAIHPCSPRRTRRTTSPQSAGGQPSEQESSLTLKQEIMQRIHAMMAQQQAVSNGGNQPMWMQEMMRQAGQQPARSRTPNPPSTPAISLTPMSTSTHPLTPCRPTSPIPPILLPNQPPVVMSLVQPLHPTLPTPPLTPPTSIPAIQLTASTTACPPAPTLPSNPPGVPMPVALATPSVLPPSLPLPTLPLTPSPSSPDIQQMTGAVACPLHPTLPSNQHAVPLLVRTTALVNPSVVVPPSTSLTPVLTPPQTPHQSVPTIPPPTAAAPCPPSPSRLAAAAPSPPVPPAVQSASPVPVTPLATPKKRRRATIQSPPVIGKKQREGTSPPVQTQPTQPTVPCFPAPLPSESSFIPIQKYDDLEDVTNQGQAVCLGTGAFGDILLKRRKSDASLVAVKQLRNVQDPNEAYSKMIKEIRCMMAVQHHREFPKVWGIIDQTTFAIEFIGDGTNFTSTDLYFFLVNPPSGLTTVDYINICLDISRGLLALHEAGWSHNDLHNGNVMIWRDPSRSNNWAAKIIDLGLTTRIDLPPPTFMFDSPKKAWCYQNCPHMAPEIVEGVCQQGVKGDIYSLGDLFHIIADNKAELNFYMGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y676</accession>
    <name>A0A8B7Y676_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110978210</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">LOC110978210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    <dbReference type="KEGG" id="aplc:110978210"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088708.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20854" checksum="2797AE61CCBBDE69" modified="2022-01-19" version="1">MSVILADCQIKDKVIQVSLTLNATFDRIMQNRERFTGKLKHFLAMKFGLSANAMRDFKFRKGSVIVEFKVSSDGVTDIDEAVNMMETEVAAGGFSFEFDGENLQAAHDSFKSNPYEVSPPTTKPPRNDLVVYIVIGVVLAIVVIIIFVSLIYCVSKSKKEAAKKQKSENLEFRDYDGGYDNKNYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6Q0</accession>
    <name>A0A8B7Y6Q0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteoglycan 4-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">LOC110977974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
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            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_022232545.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110977974"/>
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    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="14"/>
            <end position="367"/>
        </location>
    </feature>
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            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
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            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
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        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
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        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
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            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088237.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41655" checksum="8D0AD907E462FE87" modified="2022-01-19" version="1">MGKVDYNKAVSFTYNPNARSAPDEEDEDLVKERQRREESLRRAKAIEERKRAARGRGRGRGRGGRGGGQRSRPPLGKGQRTRPLESIEEARETPAVSERTSSAATSLAPSARGRGRGTGRGRGRIERAPTVQSTRPITSQSNRPVTSQSTQRPGTTKSVRPPTAKQEERLPTAKPAEPPKEEEKPREKEPESDQKEQHKEEQKQELPEQAEPKKQMKFSTAVKVRMFMRSFFKKRREPEPQQEPEQGNEEEEEEDKSKEEEQQDEENPAQEEEEKPTVAAKDEEEKEEEKEAEPEDEEKKDDENEDAAKEKTPSPEPEQKVKSPTPTPTEPEPEPEPEPQPEPKPEPEPETEPEPEPEPEPEPEPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y763</accession>
    <name>A0A8B7Y763_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110978393</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110978393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the CFAP97 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the annexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089053.1">
        <property type="nucleotide sequence ID" value="XM_022233361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y763"/>
    <dbReference type="GeneID" id="110978393"/>
    <dbReference type="KEGG" id="aplc:110978393"/>
    <dbReference type="OMA" id="CAMYMAE"/>
    <dbReference type="OrthoDB" id="2163395at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001464">
        <property type="entry name" value="Annexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018502">
        <property type="entry name" value="Annexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF175">
        <property type="entry name" value="ANNEXIN A13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00191">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13879">
        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00196">
        <property type="entry name" value="ANNEXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00335">
        <property type="entry name" value="ANX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51897">
        <property type="entry name" value="ANNEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0041">Annexin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="727"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="771"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="825"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="848"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="893"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022089053.1"/>
        </source>
    </evidence>
    <sequence length="910" mass="102044" checksum="612C164C4F76DCF2" modified="2022-01-19" version="1">MLKMPRQTGAFPPVNNLLQKKWNAKAYKQHLEKRKSVKTSLNTKTPKSYLHLQLNLKKIQLEEQRQEAIDQENRILLAKLTKVIRSAGQLDNWNEDYDELPKSLNRPHMLREQERIAAENDKISKRLLSVTAEYNVDQWEDDYLLHEYYLTLKAQETKSFEVETRGFEEDEPHFYNRDQEVATANGSVHQSEPGQTETEEQVDQVSISPSGTSKNKTVVNKKAPTIFRRPKPQPKLPLLGHSRKKEEEKRKREAASKPAPYDDKEDAARLFKATKGMTKAETAFIHTLARRTYSQRQQTKEIFEKHYELDLEVELIEVLGDEWTDIISILLAKREMIDATALRQALKGELPLTDTVMGLLCTRNNAAISVIKKAYAKEYGTQLADDIKSETKGQLRHLFLAVAKGTRMEGSEIDPDRAKQDAEILNTESEEERWKADTGKLAELLRIASFSQIREVLEQYEQLYGRRVMDEIQQQLGGDYRDALQAMVKCLYHCAMYMAERFRISLVRQNSPSLIRLVITRSEIDMPQIRKAYRQRYGETLMDAISSICQEPYKKALINMVLVHGCPANQQDQQEGETRGAFSATKVPSLPKVTSPANKTKPVRRPSPNKTATLSPTNPLVKSVKAAQQQQQPPAKESILVSRRPGAVPKKTVTVVDPRAKQTPPSSGGKPSAIRQSPSKGKRPVLGSKVALSSPNKTSRKPSVEKKEKRISGTPRILKTDSQASLKTEDPKAHETQEKPDSQEIISTSRGTDNRDGSVVREKSAGGVDTSEVQPNMNVAQGTRSSEKSGPEDKVAENVDEDSSRKSVPQTEEGQTAVVDEGSSQKDVPQTGEGQTIIDNKNDEKAVVTQTNEEGQTQAEKQAILQSNGTQQVKPNPEADDGKKAAGSTIKLENAEDGSKEAGRNEKETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAB6</accession>
    <name>A0A8B7YAB6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1</fullName>
            <ecNumber evidence="9">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">TAR RNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110978165</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20078"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022088636.1">
        <property type="nucleotide sequence ID" value="XM_022232944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAB6"/>
    <dbReference type="GeneID" id="110978165"/>
    <dbReference type="KEGG" id="aplc:110978165"/>
    <dbReference type="OMA" id="QTARSQC"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000010">
        <property type="entry name" value="probable methyltransferase TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="12">
        <location>
            <begin position="122"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022088636.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30881" checksum="C04C15C86CB6AA1F" modified="2022-01-19" version="1">MTIFHILPVLCSLASDEFLDPKLFDKDSPLLWSNSNKFHPIIRLYNPENSLIQEEYCISLCVQPSAAQAIPGMSVVSSTFESIDKDSNVQKKIIPWQDTLMPGFDDVIGTAGQEKGSRKDSLILVASLIDKAPNLGGLCRTSQIFGVSTLVVGNLRVTTDKIFQTLSVTAEKWLPIIEVPVSDLASYLQAMRHKGYTLVGVEQTARSQCLTKYQFQERTLLLLGHERTGIPVELIQLLDVCVEIPQQGIIRSLNVHVSGALLVWEYRRQRLLAQSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBA2</accession>
    <name>A0A8B7YBA2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-selectin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110978737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089665.1">
        <property type="nucleotide sequence ID" value="XM_022233973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBA2"/>
    <dbReference type="GeneID" id="110978737"/>
    <dbReference type="KEGG" id="aplc:110978737"/>
    <dbReference type="OMA" id="HANTLCK"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF6">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER M-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034579437" evidence="2">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="177"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022089665.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28752" checksum="AA552663A5C8DE68" modified="2022-01-19" version="1">MYLLKIVAIAAITAAINAAWGSAFCPSLPAMHCSCPSGWQLWRKACYRLTETKVDWESSKSACREMGGKMAAPRNLTEMKFMADLAKKNDGRYYIWIACNDSEVEGNWMCDGQEGSKPFMGWGPGQPDDAGGNQDCATIAAAHNDSMDDNNCDYTLYAVCARQANCTRHPNQPRHYCFSTDTHGRILNSTCLLGHVIREFTTDSVSACGSSCVEEPGCRSFNIKKNGGGKKLCQLNNSTSSEDKDMFQGTGDFCIYSEVCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBF8</accession>
    <name>A0A8B7YBF8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">IQ motif and ankyrin repeat domain-containing protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110978765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089720.1">
        <property type="nucleotide sequence ID" value="XM_022234028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBF8"/>
    <dbReference type="GeneID" id="110978765"/>
    <dbReference type="KEGG" id="aplc:110978765"/>
    <dbReference type="CTD" id="642574"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF194">
        <property type="entry name" value="INVERSIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="90"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="290"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="368"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022089720.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="65431" checksum="7695C109B94DE59F" modified="2022-01-19" version="1">MPPKKPTVKPAGGKPAASKTTTKSTPVKKVTPVKAGAKTPSRPAGKTAPPPKTGTQKNAAPAKPKPPSKETLAAVVIQKWVRRFLGRCRLLKLRHEKEEYEALMEKLEKEAFVAMVKREQERAEEEHRKEMEERRRRKMHQQRIKRILEAAFDGDDDEILIVLKEVEKQDMELGIGMDPMGQALRAKHQLQMVDCEDANNNTPLSEAASGGHADTIKLLIDRGADVNARGQFERTPLYRAAFAGHLTAAQVLLQHGADPRLYASDGATPEQVSANEPLTVLLQEWDVGLTDAMLSKMEAQREQRKQEERQRREAEMAKLENQLADAQKDHDTRQLQLNKAYCELNKRIEEHDKCTAKSMKTDITLQVVKDAEQDLEIAKLEAEKARERLANVKLQIREQQKTAKGLDGEPEVGVKANIKELHDVLMRDVGDKIKSDGRWPLLIDPSGRASTFLRYQDTNLLNALNPNHMQPEVIRMAVLGAIRFGKPLVLDMLEVDMFETCTDRFNEVHVGLMEDILSKELIKNEKYVYLIKDCDGPEYSKNNFNDQRTQQFKFVIVTKIEPADSLLERTYPIRIVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCV0</accession>
    <name>A0A8B7YCV0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110978650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022089491.1">
        <property type="nucleotide sequence ID" value="XM_022233799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCV0"/>
    <dbReference type="GeneID" id="110978650"/>
    <dbReference type="KEGG" id="aplc:110978650"/>
    <dbReference type="CTD" id="79618"/>
    <dbReference type="OMA" id="DSMTKMD"/>
    <dbReference type="OrthoDB" id="5856131at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040363">
        <property type="entry name" value="HMBOX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006899">
        <property type="entry name" value="HNF-1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044869">
        <property type="entry name" value="HNF-1_POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044866">
        <property type="entry name" value="HNF_P1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14618:SF0">
        <property type="entry name" value="HOMEOBOX-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14618">
        <property type="entry name" value="HOMEODOX-CONTAINING PROTEIN 1 HMBOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04814">
        <property type="entry name" value="HNF-1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51937">
        <property type="entry name" value="HNF_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51936">
        <property type="entry name" value="POU_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HNF-p1" evidence="12">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="POU-specific atypical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="244"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022089491.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="48226" checksum="4E7D52185A7A6F1D" modified="2022-01-19" version="1">MMSTPVTTVSSEPRYTIEQISLLHRLLRTGLTKQDIIHALDSMTKMDAELQASSQPLVGGAMGETGSSNYAISRSSVASSASLVSTGMQRGAGGMGGGTQIEGGASGLQGGTGLQRMPQEVSCGVENFPNVSDEEVEILFRRGPMAAKSDIRAFMSKCRVSQNQISMATGISPSYISSFLTHGFMMKRSTQELLYRWYLGKKKEMEDLGSQPDLEHQDNSSLPARPSDLSQSYTSPNGENFLPTFKRRERFTWKDSHIRILESYFSKNPYPNDFEREKITEACNSEYQQSGEPVHESKWVTSSKVYNWFANRRKDSNRRKRLSQMMDENAELQSGSVDRIAHSEHTQNLHVIEVHQGDGESHDAGSLSGREVHVVQLQMDNEQTESDGRQHRQREDRKVETTTDTKNFGGVNTIYTLIEAVEESDMMKHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE15</accession>
    <name>A0A8B7YE15_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110978871</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Golgi apparatus</location>
            <location evidence="2 11">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089881.1">
        <property type="nucleotide sequence ID" value="XM_022234189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE15"/>
    <dbReference type="GeneID" id="110978871"/>
    <dbReference type="KEGG" id="aplc:110978871"/>
    <dbReference type="CTD" id="27095"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000003">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022089881.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22525" checksum="F593CCF0FC69BD6E" modified="2022-01-19" version="1">MGRGNDVCINGKSGHVKELEYFAVGVEQVLRADSQSQELFTLTYGSLVSQLVKDYESDEEVNKQLDKMGYNIGIRLVEDFLARSGERRCNDFRETADIIAKSGFKMFLGITPTVTNWSAAGDEFSLVFDNNPLTDFVELPEEHSQLNYSNILCGVIRGALETVQMDVNVRFVQDVLKGDNQTEVKVKFIKRLEDAVPAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEQ5</accession>
    <name>A0A8B7YEQ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glia maturation factor gamma-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090880.1">
        <property type="nucleotide sequence ID" value="XM_022235188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEQ5"/>
    <dbReference type="GeneID" id="110979415"/>
    <dbReference type="KEGG" id="aplc:110979415"/>
    <dbReference type="OMA" id="EWKMLYA"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000026">
        <property type="entry name" value="Glia maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="7">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022090880.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16335" checksum="89F55D99E710185E" modified="2022-01-19" version="1">MASGLTVCTIDDEVKEKLKKFRFRQKKTNAALIFKILEQKVEVVLDEEFDDISVDELQAELPSAQPRYVYLSYCYKHSDGRVSYPLIFIFISPIGCKPELQMMYAGTKNSLVGEAGATKVFELRSTEELTEEYLLEKLAFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YER5</accession>
    <name>A0A8B7YER5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein SSUH2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090890.1">
        <property type="nucleotide sequence ID" value="XM_022235198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YER5"/>
    <dbReference type="GeneID" id="110979424"/>
    <dbReference type="KEGG" id="aplc:110979424"/>
    <dbReference type="OMA" id="GRGFNKC"/>
    <dbReference type="OrthoDB" id="3355217at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022090890.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="50695" checksum="1E7EED5A8090A3AC" modified="2022-01-19" version="1">MAELTGLTGPSQSLPPVESSGIASRQRSSYGQSVRLPPLSQQSQSQAPPPYNDVEHNTLLASGGLRGAGMDQSIPWRAPPGETDTPTYHWPDAPDTDVEDNEKVREPVYKMAHALPTIPGHERTSTKESKPAERPKLQIPHNDRREFKSGNLTISHEEAKGCLVDMTSHRCCYGSGAARELEVQEIEYSAAAKYSLETFVESRTSKRACIPYKGQTVDSPQEGAPPALWEAAIEAPEKYKPCVKTVRVPHCSIIETCYACSGRGFNKCYRCKGRGKTKCRYCKARGQRGNKECEYCRGKGRQRCFRCNGHAVISCSVCEAYKQLEFFIEVTSTFKVKTDEYLHHADKRLPRKLLRGIEGITLFEEEAQIVAPLSNFPTLEVNSQSEKLVAKHANVKTERLILQRHKLVGIPIAQVEYTRKGKGGKYWLYGQQRKVYAPDYPQQCCCSCRCPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFS3</accession>
    <name>A0A8B7YFS3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein F13E9.13, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BtpA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092089.1">
        <property type="nucleotide sequence ID" value="XM_022236397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFS3"/>
    <dbReference type="GeneID" id="110980075"/>
    <dbReference type="KEGG" id="aplc:110980075"/>
    <dbReference type="OrthoDB" id="10045006at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd04722">
        <property type="entry name" value="TIM_phosphate_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005137">
        <property type="entry name" value="BtpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00259">
        <property type="entry name" value="thylakoid_BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381:SF3">
        <property type="entry name" value="SGC REGION PROTEIN SGCQ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21381">
        <property type="entry name" value="ZGC:162297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03437">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005956">
        <property type="entry name" value="BtpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092089.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="33589" checksum="5109289B580A3E0F" modified="2022-01-19" version="1">MSLCVLWEVFPRSVIRGFFLEVTPILVGVKMSRNALSLFSQLFGRTHGVIIGMIHVKALPGSPRYRLPVKDIIRLACEEAEGYRQAGVDAIIIENMHDVPYLQADHLGSEVTASMTAVASKVREVCPSMPCGVQILSGANKEALSVAMVAGLDFIRAEGFVFSHVGDEGFLNSCAGELLRYRKNIGAEEVKIFTDIKKKHCSSHAITADVSIAETASAAEFFGSDGVIVTGSVTGQEASVQEIKDVQASVDIPVLVGSGVTLSNVEQYLGASGLIVGSHFKHNGLWHYHPDFSNVKKFMDKVQNLRGDPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGC0</accession>
    <name>A0A8B7YGC0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 179B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110979710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM179 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091445.1">
        <property type="nucleotide sequence ID" value="XM_022235753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGC0"/>
    <dbReference type="GeneID" id="110979710"/>
    <dbReference type="KEGG" id="aplc:110979710"/>
    <dbReference type="OMA" id="FMAYRIQ"/>
    <dbReference type="OrthoDB" id="6423876at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029673">
        <property type="entry name" value="TMEM179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059010">
        <property type="entry name" value="TMEM179-179B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26158">
        <property type="entry name" value="Claudin_TMEM179-179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022091445.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23040" checksum="CFBCCA68A01D6F86" modified="2022-01-19" version="1">MPATATIVNIVEVAVLLVAFGCGMAASIMIGVTSTQMGGCVLKASVTLFDPTHFTLSYSSQSRCQFCLAAQVIGILLALVFMAYRIQVICRGKLEIQAFGRFVATIVFGVMAFLVLVEACLVTVGLKTFCNNLLDLEGAVWPDTCAGFQGGIDWQSIDGSAFYYNLTTAEAVSWISLLCWLCLMGISLVTSFCLNRRIGGLARAQHTARAKPVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGS6</accession>
    <name>A0A8B7YGS6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110980244</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092439.1">
        <property type="nucleotide sequence ID" value="XM_022236747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGS6"/>
    <dbReference type="GeneID" id="110980244"/>
    <dbReference type="KEGG" id="aplc:110980244"/>
    <dbReference type="OMA" id="VLWVLEM"/>
    <dbReference type="OrthoDB" id="1733721at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022092439.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14477" checksum="95389F06543A9655" modified="2022-01-19" version="1">MTKASSRGMGTGEKKAAAKVKAPTATMAGSGKKDKHRKKRKESYNVYIYKVLKQVHPDTGISSRAISIMNSFVNDIFERIASEASRLAQYNKKSTISSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGS8</accession>
    <name>A0A8B7YGS8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prominin-1-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091792.1">
        <property type="nucleotide sequence ID" value="XM_022236100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGS8"/>
    <dbReference type="GeneID" id="110979921"/>
    <dbReference type="KEGG" id="aplc:110979921"/>
    <dbReference type="OMA" id="IVCAYMV"/>
    <dbReference type="OrthoDB" id="6229420at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071914">
        <property type="term" value="C:prominosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034189070" evidence="8">
        <location>
            <begin position="26"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="800"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022091792.1"/>
        </source>
    </evidence>
    <sequence length="864" mass="94043" checksum="F10A6CCC3AFA8D22" modified="2022-01-19" version="1">MANAELYRWLSATVLVLVLFSVGQCANSNNNGNLTLDDVPSDHVYLSSGEYDEGGFPLPTTWGLINSFLRTISPAPPPYDLINGLLSGTTSLTVDLLTGSISQLTGNLMGFAICFIIGALFVVIFPIVALCFCCCRCCCNNCGGKMYQKQGKYDRTKRVIFGFCLVLCLGFIIGGVATAFCVNTFTTQKVESLPQDVVNNIDDMVSFVTNTLQEINFTVVDQLNYTLSQVGQDLVDIDQLVGVPVKESLSTIVQPAIDAIYPLDTSISNTYNGLVNINTTQANVEVMWEDVKSRVDQVASDIGAACSSCGCCGSAPDYSGLSMNADWRDINIGMMHGTFPQIAVDNSIDAMEDVNNADLSSSADEGAANFDNLPQTLKNTTQSQIDDILNTLNGLETSIAGLLTSTTSELSGIIGQIDGYKDTINDITPLIQQYDPYRSYALIGFYSILLVIAVLFLFGLILGVAGYNTEVTPSQRGSCSHCGGIFMMAAVGIAFIFLTFFMLFTMLLFIVGGPFDRLFCDPLVSGELFTQTIDKENALGPGYFLGQTLFGDGNISLTLTGILDDCENNTAVYEAFKLENFLNISDLLNFQQFIPDIGSQFTNVTGDLTAVDILTPSTRQILIDFRDSPADNINWTLFKEELASDLTNDVNNGNDLSVLASLLNTFAAGLSSPDDSTFQDLATNLTIIQTNYIAPLLAQRDTLSMYITDLESETGNIDTLVNDTIDAADAAQGHLDTTSPNLIAQEVESYAKRILGYPEQFVSYALDQLQTQIGKCRPVYNLWTSLIASFCRGFLESLNALWLIMGWCIFFLVPSTIFGVKLAKHYRRMDYDDYDGNQDMEMAEKYGGGGSSHFSSNKVAPSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH09</accession>
    <name>A0A8B7YH09_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110979964 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979964</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091872.1">
        <property type="nucleotide sequence ID" value="XM_022236180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH09"/>
    <dbReference type="GeneID" id="110979964"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="168"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022091872.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26277" checksum="8CAD472B8E592869" modified="2022-01-19" version="1">MGAHQQIMKSGNPSLCTFMIMDYFTCANTEEIERTELDESPRGAEAANEENDMHVPDGLSRPPSEVPASGNIVPQETASADRIKNCRRGSSSTSASTGSLSRTNYRDIEKCPVCGNDVPLDQQWFTATTNRENGILRGRKLYCREQCARSDRQGDEVVRPIRFLFKYCAVCLPEDNIWMQVAVCNECHNYTCCKCVKGIVGSKEWECPLCRCKLCEVVNLMPLRGHVTDSGSLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK92</accession>
    <name>A0A8B7YK92_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arf-GAP with dual PH domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110980917</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093683.1">
        <property type="nucleotide sequence ID" value="XM_022237991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK92"/>
    <dbReference type="GeneID" id="110980917"/>
    <dbReference type="KEGG" id="aplc:110980917"/>
    <dbReference type="OMA" id="YYNRNDA"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13252">
        <property type="entry name" value="PH1_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000080">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037849">
        <property type="entry name" value="PH1_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF2">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="146"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="272"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022093683.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43772" checksum="D835733E5DC2CC93" modified="2022-01-19" version="1">MSADPSVKKLLEVIKKPGNNVCADCGERIVRDDKDENQACHGNRANWSSYNLGVFLCVPCASVHRKLGVHISKVTSVQLDRWNEDQVEFMEVNGNLKAKEKYELDVPVSYRRPMLPSDPEVVREQWIRGKYERQEFVNVNLQKYRTKEMEGVMWKKLRDKQNFMERRFVLSETDYTLKYYNRADAKEPKAVIDLGKLHVAFCPDKVGNPNGMQLYFEQKGGEIRNIFVYTDTGKEIIDWYNAIRHMKYNRLMVAFPGGLCQEEITKILNKGDIIKEGWLHKTGSKGNEAFRKRWVILTHKRITYYETPLDDVCKKSVVLGTNLSEYKCIEGVPPGKLEQGFSFTVRVPGRDFFFSAETGTERKNWMTAINKEIGVVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKH0</accession>
    <name>A0A8B7YKH0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ectodysplasin-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110980968</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093759.1">
        <property type="nucleotide sequence ID" value="XM_022238067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKH0"/>
    <dbReference type="GeneID" id="110980968"/>
    <dbReference type="KEGG" id="aplc:110980968"/>
    <dbReference type="OMA" id="CKSSGVM"/>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051748">
        <property type="entry name" value="TNF_Ligand_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15151:SF24">
        <property type="entry name" value="A PROLIFERATION-INDUCING LIGAND-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15151">
        <property type="entry name" value="PROTEIN EIGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="10">
        <location>
            <begin position="233"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093759.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="39679" checksum="0C26B538A6CC3A5F" modified="2022-01-19" version="1">MENSKKKPLVGSYMETPLELRDDSSKTSHNSTKGSCLDRETSTRWRRPQCNLTAYLTLILTLFVALVGGISVLRMRELERRLAWQEREIENLDDRVKQLSRLEDTYLPGLEAMPSRHLLAFDGADCDCPAGPKGDPGPRGERGRSGRDGRPGKDGHRGPPGIPGLDGRPGPPGEKGERGDIGLPGERGPPGSRGLKGDQGEPGVSGPPGPRGPTGTVEGLDSLQINRHVVFARAIHLQGIPSDQVSGMRRLGFQGLLRDWTISTNSGGFALESDGNVTVTERGQYFIYSSVLFYDGSAFYGAHTNINGKNFLKCTGARASSAAKFGPCSASGVALLNEGDKVGIVSVYPMKEVEMRPESTYFGIIKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YP01</accession>
    <name>A0A8B7YP01_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Uncharacterized protein LOC110981274 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC110981274</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094395.1">
        <property type="nucleotide sequence ID" value="XM_022238703.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094396.1">
        <property type="nucleotide sequence ID" value="XM_022238704.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094397.1">
        <property type="nucleotide sequence ID" value="XM_022238705.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981274"/>
    <dbReference type="KEGG" id="aplc:110981274"/>
    <dbReference type="OMA" id="HWLPEPP"/>
    <dbReference type="OrthoDB" id="10029564at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002142">
        <property type="term" value="C:stereocilia ankle link complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032426">
        <property type="term" value="C:stereocilium tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000090">
        <property type="entry name" value="PDZ domain containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030237">
        <property type="entry name" value="Harmonin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051844">
        <property type="entry name" value="USH2_Complex_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116">
        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23116:SF29">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21219">
        <property type="entry name" value="USH1C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="267"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="1249"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="752"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="898"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="956"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="929"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="956"/>
            <end position="969"/>
        </location>
    </feature>
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        <location>
            <begin position="1046"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1091"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1146"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022094395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022094396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022094397.1"/>
        </source>
    </evidence>
    <sequence length="1344" mass="148465" checksum="8F2ACC05BDCACC00" modified="2022-01-19" version="1">MGRSTSDSHQRKLQLFHRKSKILLNDLERDYLHDILKQYEVYKDVKRLMLRLVDILDTPAKLDLLVEIRGLIPKVHLAQFDWLAPYAKMAHPVILTSTNHGRSSANGSVKHLRKSRSDGSVRGTKGFHDNPTTAVRMVTIDKDREALGISIRGGSEKGQGIFISTVEPGSVEELLGLSPGDQILEVNNISFDNISSSSASMVLQGSSRLRLKVKQSGWVQGHRIAKEKTTWFDTVRRKIVAGEFNDVDPSHAAMGGTRLLSGGDERRVIITPSPRRCIGFNIRGGMEYGVGIYVSKVDKGGLAEAHGISVGDQIIDVNGVSTESATHAQAVQLIRNQPCLIMTIRSVNRYPAYKELCEDYGWADRDTQHKRRHSSSPTSGTTPLTHTELIDAIPVEVAEQYTQTHAHNESNNWAPNQSITMSPTPIPKSSRSSVATETTSLIQKHVPLPSQEQKSAVEPKQASDRASSPSRSGNQTIMGTTALTNDKRIGRSHSMKFPGEKELPVFEKEMQGKESRRVQRNRTFREILFGMKMKSRDKKEKAERQRDKKAADNPKRIKKRYPSAAAYASLNKKPSVEQQQVGGNVNQSEVMTASWATRRPNERESVANSNPGSIARRRSSSPVSTFLPQQVTTADAQQPTTTAFMHGAGTQLMYSEACYASAMNVLEDMAKKLLNEDERAAIMRHVRWYHQEGRIENLVLPILAILDKPEKVLLLREVRGVVAPSDLGRFDSMVSRRELQAYEQLQFGRKDLSQPLNSMRRNSVGKPRKTILEPKPDQEGKFLLQTQEDIEQDRRRQHELEELRRENQSKKSGYIDQGKGEGEESGTEDDNSLHNSDIAMSMFDNPGKSNFAEPEMKTGSPDFKEGSKTSNASLASTGEESDVVVAVRESIVEKLPVTLDKHQQSTSEEQNLGVALKEGGEENSALGSTEKDGKRATDWSDENLLPIVLVQDEVKEEEKERWVLPRIEDDTLETDDVSPQAPMVYDAEIYGLDGSEDGEEVDLPKFEDGSSDSDADSSAPEDSLKPNKSGLYSLIQTNSDSRRGVATNSTATSPAWSSPDAFSPVSEMTLPPTPTSSVGSPLSPAVPKTPPNTVRSPLIPSSNESASGTYDAPVAEEPIYAKVDLSRKKSKQPVKDSLSVEGSVDGSHDSADSDRRSPFRVTFTEYRGSPVPSRKGILKNSFREDEAPSVEKRRANSDYMDIEDINLGEPAPFQEIDAEMKSRMASSPGTAQAEDKTVEQLKTGMETMTVTLSKSRPSLGISVSGGRDSKHQPEVRIDRVFPGGAASDNGILQAGCEVLFVDGDSLQDVTHPQAVDIIRKAYHDKNRGTIEFVVKQPLEMDTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPB5</accession>
    <name>A0A8B7YPB5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 69-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094512.1">
        <property type="nucleotide sequence ID" value="XM_022238820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPB5"/>
    <dbReference type="GeneID" id="110981325"/>
    <dbReference type="KEGG" id="aplc:110981325"/>
    <dbReference type="CTD" id="100130742"/>
    <dbReference type="OMA" id="CFNKSGH"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF57">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="111"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022094512.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43325" checksum="450E9B02852E2A0C" modified="2022-01-19" version="1">MNFHTESGVQLLHIEASLGHLQMRLVKESKLRRYQQKRSKTMQVKLFKISQQYQVGELTTSELLSTCKHQNGPALRRLAVLNLGNNCLEELPESLATLHALEKLHLFGNQIKTIDAKIIGDLRNLTFLNLNNNQIKTIPSAINRLVNLQYLSLDGNQLTSLPAEMCALSKLTELHAAGNQLSALPLEIGFLVKLSRLHVQKNKIKELPEGLGKLIHLEIIDAAANEIRIFPTEIHKLPLKELYCEENPLLDALPVHSIQEEEILTLKEITARYVMKQLKDRRKMVKYGDKVFYEENPAWSYMRRAIRHYPNIRDMLAQASKCALCGASFLNTWLECVRFVDGHRDLKLSNSPGRVPIRALLCSYKCFNTPGHEFYGIAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPI3</accession>
    <name>A0A8B7YPI3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane anterior posterior transformation protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110981254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094360.1">
        <property type="nucleotide sequence ID" value="XM_022238668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPI3"/>
    <dbReference type="GeneID" id="110981254"/>
    <dbReference type="KEGG" id="aplc:110981254"/>
    <dbReference type="CTD" id="202018"/>
    <dbReference type="OMA" id="TIMLIRV"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022094360.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="63166" checksum="DC15A8045A107BF4" modified="2022-01-19" version="1">MAAVGKCKDPYSGDAEMECPSESSDITKEAEAEHGKSPETVGQFSDSGDAPVIEEKDLSLWRYFSAEVTRGYLLEHDEARYALKRQRVYTFIRIPKELEKMMMYGFFLCMDAFLFIFTFLPLRVIMALFRLVSHPCVIHRGQRLEPAQICDILKAVILIACIWLLQFVDVSMLYHLVRGQAVIKLYIIYNMLEVADRLFSSFGQDILDTLFWTATEPRDKKREHLGILPHLLMAIIYVFLHAVLVLLQATTLNVAFNSHSKALLTIMMSNNFVELKGSVFKKFEKYNLYQMSCSDIRERYHYMILLFYVVLRNMTEFNWNIDHFWDLIPDLISVLIAEILVDWVKHAFITKFNSISAEVYTEYRANLAFDMVTSRKKNAFSDHSDVVARRMGFIPLPLACLVYRIVVQSFKIHGTAGIVLIFLFYLCLTAFKVLNSILLLGKACKYVKEANLDVTVLPPKKPSPSPSPPPPSSATAPTAPSGDAAGETRRVPPAISSQTLLSADSSVNLLASGPDVGPLSPMEAGKSLTKEDILKSKSDRKRTLSEIDRYTLCSNRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPQ2</accession>
    <name>A0A8B7YPQ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Uncharacterized protein LOC110981281</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14 15 16" type="primary">LOC110981281</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094427.1">
        <property type="nucleotide sequence ID" value="XM_022238735.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094428.1">
        <property type="nucleotide sequence ID" value="XM_022238736.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094429.1">
        <property type="nucleotide sequence ID" value="XM_022238737.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094430.1">
        <property type="nucleotide sequence ID" value="XM_022238738.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094431.1">
        <property type="nucleotide sequence ID" value="XM_022238739.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094432.1">
        <property type="nucleotide sequence ID" value="XM_022238740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPQ2"/>
    <dbReference type="GeneID" id="110981281"/>
    <dbReference type="KEGG" id="aplc:110981281"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF393">
        <property type="entry name" value="CHROMATIN-LINKED ADAPTOR FOR MSL PROTEINS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="612"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="666"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="761"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="893"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="77"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="863"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="918"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1167"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="923"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1192"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1208"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1233"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1248"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022094427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022094428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022094429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022094430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022094431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022094432.1"/>
        </source>
    </evidence>
    <sequence length="1268" mass="138556" checksum="842962175840FD4B" modified="2022-01-19" version="1">MSSSTVSCNEETIDRGGDSKSSSCLNLSTSNIVDAEVANLQEKDPVKSVPPVTSQQITKTLDERFLGHLGLRKIDKECQQGGSKTENAASKKDSGKEYIGIGVDQQGGAGGSMSGDGQNSKEDSDLQVKGSSRQASQPKVLPASQPLKAVSDVSKFSTIKVISPVGENSSLAELDISGMNNGISKDGQGASIPSSNSLSNPVKNSPIYIKVKLEEKDVTVICCPVALLLQHKEILDVTLQANDPNSYSITCRKCSHVVSDPYTMLQHLKVQHQIQGCLQKLLNLNSQYLSCMSQPLCVNITGVLTLPDGLSDMEQGIIRFNSMGIPKLSFVCRLCPLSFHTARGLCAHHQYFIRSRSQQTSDNSMWFCRLCPRQFQSFMDYYAHHKWMRVAKELFVSTDQVNKRKRFEVMNESGKVVASMEVPKTHSFAIKPWPVTNPDSCEDIGWGHKPSLNDRAPQGKVEPLIPEADDQAFYIDAGTPGPSTITLVSTPDGISSKQPDEADKGKRMTPPLFQTLDSLCRRLAQRVDTSTGLDKVISVGDKQIDEDHEYLCGICHKTFPRLPQMQGHMGSHVRRRRANKYAPPPPVAVASSPADPPSVERAPTVEPLDVEYKCGVCSETFPKLDQMEIHMECHNRPHQTTQPPVKSPPMKSLDTPFLETVKLMSLTCDICHWSFPTERKLWDHRSTHAQKKTEETGSSMSSRASGGIQRKTLYVCVYCKKSFAREVNLRFHLKKHSTEVADESSQTTGNVLTSPDMQAQHACSVCGRAFRSHRQLRSHMVWHAKFHKGADKPPVSLVEAGGASKKSLVCNTCDKVCCSDWELRLHKKKHASPKRLLVRHTLANEDSDPAKKRTLAQRACNLNNKEGVSDTAAPGSSTLRRSTRPRREGLYKYFCRNCRSYFQSSQQFARHMAVHTNMAGPSHRTSPGSPSNKTRGSDSGQVLMQKQSDGDVSDDSGGGIDMSWSPSPSSADEQPPPIDKLGSDTSEILTDKKVSEENENCVTTEDSGPAVEDTSQILKETAADEQSPHSSAKPTEKQNTDPVMSSAVCKGASAEMKEKILALNQGEAAEEQSVPLCSDSKVCEDVDVLMTAANQVTGSNKSSAGSEGLKILSQSKKLSANSSIWDGIMPNVETQPKAPSIVLLEDCQVKKQDRDLKTQTQTTVYENSSSVMVRVSPEGSRIAPDEQASETNEAHLQTDDQSGKELSTDASCQNTVDDTSNTVTQKKDKGSGLISTEECSASPSFNKGHVEATERPVQKNIGGPPSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPS4</accession>
    <name>A0A8B7YPS4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110980780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093431.1">
        <property type="nucleotide sequence ID" value="XM_022237739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPS4"/>
    <dbReference type="GeneID" id="110980780"/>
    <dbReference type="KEGG" id="aplc:110980780"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF96">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022093431.1"/>
        </source>
    </evidence>
    <sequence length="669" mass="74164" checksum="BC9728E21E7146B0" modified="2022-01-19" version="1">MSIKYSTTSPNDDQKISEKAEKANMNEASLAVDDTVEVVDDGFDGPLDDRSCRDVICLILFLAFWVGMGYVAVVSLLDGQPERIIYGADSYGNVCGKSNTAIAGVNMSGQNLIDKPYVFTFNPEAVANPTTTTKLLCVSECPDVVLLTKNDLVELALNRSIFLCDYNLAAEDYAAAEQGALAACPSTPVDVSTPIFNRCIPSTAVGIASSLLDAEWLKRAVADVENSWREILYLCLISFGLAIAVLILLRFFAGVLIWTTVFVFVFGSLGGTGYLWYRWWQEKSVLDALPADAAKDDQEHTVKTMLTYAGIATGVTVILLLVLLVMRKRIALVVALFKEAGKAIACIPFLLLQPIWTILAMVVLCAYWGFVYLYLVTAGKPELDSETGFVIYKADALGPYMWWYHLFGLLWGSQFLVACQQCAIAGAVAAWFFARDKSQLRWPILQSIKRIIRYHLGSLAFGSLIIALVMLARIILGYIQSRLRHSQSDIVAYILKCLQCCLWLFEKVLRYINRNAYIEIAIYGYSFCKAARKAFTLIVSNALRVAAINSVGDFVLLLGKATVVAAVVVIGMQLLKDKADVHYDFVPITLAAIFAFLLSHIFLSVYEMAIDTLFLCFCEDCERNDGITRPYYMSKDLMTFVDNARKAQDMKDIKRQAKRAAAQQAADNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQ01</accession>
    <name>A0A8B7YQ01_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein kinase SBK1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095353.1">
        <property type="nucleotide sequence ID" value="XM_022239661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQ01"/>
    <dbReference type="GeneID" id="110981776"/>
    <dbReference type="KEGG" id="aplc:110981776"/>
    <dbReference type="CTD" id="388228"/>
    <dbReference type="OMA" id="HETACKL"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022095353.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42802" checksum="3043119543F80976" modified="2022-01-19" version="1">MDPTHANTMKQEEQSLPRQARDTPEASPAEDALSCPGNFIAIRLLSRGTFSKVELVVEKTTGKRVVLKYHNKLRIRMAEYLREFQTSCRLIHPAILVTYDQPIETDKAFIIVQEYAAQGDLLEAITPQQGLDEERAKSCLSQTASALTFMHKRLLVHGNVKPENILVFDTNMTIVKLSNFRDTQRRGDTMTKRAPTSPYTAPEISSTVVNEGYTTDYSQDIWAFGVVAFCVLTGVFPWGTATTEDTSFRNFTQWQKRRANLAPLEWRKLSSKIQKFLKKILDPIAERRCPVDEINKYLREQWLKAQPDQANPKEGDGSGDESPRAGDVTAMKELRLMLESHGVVTCSDSSLKRQRIDEWVQAACQQPADASKTQSASAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQ97</accession>
    <name>A0A8B7YQ97_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exportin-6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110980871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093601.1">
        <property type="nucleotide sequence ID" value="XM_022237909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQ97"/>
    <dbReference type="GeneID" id="110980871"/>
    <dbReference type="KEGG" id="aplc:110980871"/>
    <dbReference type="CTD" id="23214"/>
    <dbReference type="OMA" id="KITRFNH"/>
    <dbReference type="OrthoDB" id="10261013at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000147">
        <property type="entry name" value="exportin-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040016">
        <property type="entry name" value="XPO6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21452:SF4">
        <property type="entry name" value="EXPORTIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="31"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022093601.1"/>
        </source>
    </evidence>
    <sequence length="1159" mass="132252" checksum="DA58BECAE8CDCD8F" modified="2022-01-19" version="1">MASNESSLRALESLMNEFFSLATVNQRKREIEELLNNFSAQSGSWRHCFYFLAHTHNEYVMMYALSVFENLINRQWLGVDAQDKMEIRSSLSKFLLSHHKLVPPFICNKLIKVIVCIGRLDWPHFYPDFFSNIIQLIHQPQMVTLGLRMLQTTSEELASPREDLSVARKEQLQRLLLDQIPTILSIVTHILETILDKHRQLVTTATPPPSPTHGDSNDGSPSHIAYGSSPLQSGSSIIRSMFKATPVSKQNVLPLPPLDQESEQVSLLCLDCLCHLFSWIPLSGNITPNLLTTIFHFANFGCDIQSVQGLGGSASPLAHKDPNNSGSSSFSSSGSSSLGVLAMSCINEIMAKNCVPTDFEEYLLKMFQQAFQLLQRVTKDNTEQSVGNKMSELDERYVEKFTEFLQLFVSIHLRRFESNTHFPVLEFLTLLFKYTFQQPSHEGYFSCLDIWAIFIDYLLDKTSTSRGANSNNLVHIDRYKDALVSLITEILHKLQFRCNQSQLEEIDDEILNDDSETEWQNFLRQCLEIIAKVAELLPTEAFRVLYPPFQEYLDIYLGLGQFITETPEGQRLNITAEHECRRLHCTLRDLSSLFQALGRLADHFIAERLSERFDDALSLIDKFCQVTVYGTKMKLYKVKTAIPTVLKADFIDVHAQALAALQAFTHWISQFYGEVQRNSQHHDKFVPLVTNIINAVTPLLAKQVPEKILVSAAHLFLSVATTVRPTFLIELSSVQMLFKDVSGGSLTGLQDEVQLLVCRGLSNILILPWPNVPESDQQWVLRSEHHAEFIQRLTKEFCSLKTVSQLAKDKSLQERAKPTIRRALQLLSDQVESIAGEVSKTKQICHNSLQDSIDVALYLFPIYIQQSDVINDMMGFYLATFQSLRVQMGIPAIQHTITIFLDLFTRERLTETILEEGNKGRGVVEKFLQILEIIVQEPGSAFKAFLPTIIGICMDHIYPIVAQRASPDIKPALYKLLFELLHSKWRYFFSVSVLTKLQSGTETVENEQQFVAIMQAFGQSFLQPDIDIFKQNLESLETLNAKYKLYHKKIFRDLMLYSFLNVFLQVMLHKSHDLLQEEIVVTVYNMAAVDFHNFFGTFLLQFLQSFDGLDGNQRQTLECNYKKDQDLPSFTQNLARLINDLRYYRICNSALPAGSVKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRY3</accession>
    <name>A0A8B7YRY3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110981813</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095447.1">
        <property type="nucleotide sequence ID" value="XM_022239755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRY3"/>
    <dbReference type="GeneID" id="110981813"/>
    <dbReference type="KEGG" id="aplc:110981813"/>
    <dbReference type="OrthoDB" id="10254418at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp_TsuA/YedE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF151">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="541"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="576"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="750"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="782"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="44"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022095447.1"/>
        </source>
    </evidence>
    <sequence length="817" mass="88320" checksum="6EAF66380BD2A882" modified="2022-01-19" version="1">MMERVSRLDSVEVQTLSLYRLTINEILEKFKDGSLTCEDYMNRVIRRATELKAFNYFISMDTDRMMDDAKEADARYRRKTHRHLEGIPIAVKDNIDIEGEVTGAGTSGLAGRRAKRTAEVVRRLLAAGAINAGRTNMHEMACGITSANLYTGACHNFFNYDFSCGGSSGGSGGAVGADIVPVALGTDTGGSIRVPASFNGIFGLRPSIGRWPADFGVKFTHLKDSVGPLVRSAKDIAILDSVMTGEEVYRDLAPSEIRIGVPKSHFWEDLDPEVQTYATECLEVLRDQGFTIVADGEIPGVGEFQRKYKFLTNKKEAVLRLEEWLQLHKHDVSPEAIVDVIACPRVRSIFQDALRNPPSEEEYGRALKARDDLLRNLQEYFQDQRVDCILMPATKIAPQRLDILDSDPVPGREAGESLILTVTSNSDFANVCDHPSLVIPGGLSRAGGVPFGLQIDGRRGMDQKLIAVGITIQRALKIQAVFEPATIRDQFVYSRFIMLKTFLSALTTSIICFCLLAALPPTRKYFLQIRQGYLACLTRKGALMSVSGGVVLGAGMALCASCPGIVLAQIGASVPNAGYTLLGCFAGVLLYALTESSVRNLFASSLRKPQTVDHYLGIPYPLLGVTTATLTSSVVFIFESLFPWQTQYEGWNAGPGESLLAVRAWPPYMSGILIGLLQVPVIFTVGDTVGGSQSYCTMLSQLCVSRTLEEKMPYLTQYKRGIDNWWQVLFVIGAVGGACISAASSSSLGAAGGITPTAAFVGGVLMLYGARMAGGCTSGHGLSGFGLMMALSAVTVPAMFAGGTAMGFFIRYLGNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YS98</accession>
    <name>A0A8B7YS98_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096159.1">
        <property type="nucleotide sequence ID" value="XM_022240467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YS98"/>
    <dbReference type="GeneID" id="110982208"/>
    <dbReference type="KEGG" id="aplc:110982208"/>
    <dbReference type="OMA" id="FRIENLC"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11054">
        <property type="entry name" value="CYP24A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF120">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022096159.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="61759" checksum="BDB48A3E0E9BA291" modified="2022-01-19" version="1">MYRTRLLTKCPPVKKGWPVTTVPWSRSKTVLLEKTASATEVPKTVRPFEEIPGPKLWPIVGCLPNYRASDFKPEQYHKMWQRRYEEYGKESKIVAERVFHRQWVNVYSPATAKQVFAQEGKYPERPRVVMYMLRKEHLGHLGVAMGEGVQWKQGRSLWNRKVLRPQAVEDYIPRINDVVDDFIEHIRHLAMAGPREVDGHQLKPGEVPNLLTEIMKCSLEMMGSITLSKRLGGIKPGLDLDLDAHRFLTENTLFWPHSTKLDMSAFQLFRYFPNKTYKAMKRHWLNMCTITSKLMEEYSDRMKETLESEDLGEDTAPDVYSYFLAKNTPATELLGHMQDLLQVSMDTTSNSMNLLLYCIASNPRVQEKLYNEVSEVLQGGSVTVDKLKDLRYLKCCVKESSRMFMTIPGTSRILDHDIVINDYNVPKGTYINMCFQVMCRDPEIFEEPNEYRPERWLDVRKAPDMAFSHLPFGFGPRSCVGRRLVDQEMYILLANLVSKFRIENLCDSEPDLKWIGINLTASEPVRLAFHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTC8</accession>
    <name>A0A8B7YTC8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110982456</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022096544.1">
        <property type="nucleotide sequence ID" value="XM_022240852.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982456"/>
    <dbReference type="KEGG" id="aplc:110982456"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12547">
        <property type="entry name" value="RRM1_2_PAR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000008">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034464">
        <property type="entry name" value="PAR10_RRM1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF102">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="10">
        <location>
            <begin position="1574"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="10">
        <location>
            <begin position="1807"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="10">
        <location>
            <begin position="2033"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="8">
        <location>
            <begin position="2348"/>
            <end position="2424"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="9">
        <location>
            <begin position="2432"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022096544.1"/>
        </source>
    </evidence>
    <sequence length="2629" mass="286690" checksum="88ABE50974789518" modified="2022-01-19" version="1">MASSDQSQQTSIHVLAPPIRSLKQQSKFLNKLYLYFQKTSASSNDIKNVSMLSSDEEALRVKVNFTKPSDVKHILSRTHHKLVCNGKTIPLHVEPFRPTKTPVSTAPPVKSDSVVKVQSLDSLKIHDSDSDASKGSTGHTNGQSLAAGCGENPLSKPTSRMTQVSCNEGVLQTSGLYTPVCFEKIATPACLALSDTSPSASSVTTPSPVTQLTVHTSTVSQLTSPLPAVPPDISPAGPPSATVAPPTTVNVTAPSSTPPLAMRTPITSQVTSTLPAVSSNAYPAAPPATVAPPNTVSIIAPQSTTSVKECAPIISQVTPPVSSALPSPTFIAPQTMSSELASPSNRTGPLTASAPMAQLASQSTTMPGNPSPVQEVPSSTAVHSTGASPIAPHSTTPFPMHTSIVSQLTSFLPAAPPDASPTLSPSTPAAPPSFVSVIAPPCFAPVTTVPSNSSVVLHPSSPIAPPTVASLIAPAPTSPLTVSAPMMLEPALPLLTTPQNPPPAVHSPMPIAPPFTASRIPPFIPPLEVSARMASEPVSPSTSLPLHESPAVSSPTPVAPPHVPALVNSPNVDPTMHPSSIDGTTTVAGSSVQDFQTEMLDMLTSVLQNTPSRDVCVESSDMAANLENRISTQSVPYNRGGWSMGHFGYPPPYQHPSEMTYTVNITKEVARVETGIWGNPYSPPVSYIPPGSPFPGLGLEAAVGSFIDPHQFYQDGMQPFNETGQPLEAAVGSFIDPHQFYQDGMQPFNETGQPLGAPAHHFGYRMPAWDPHTPALMPANENFPEHAPQMVSTDGFRDFTTHATPAYENNTVLQAEGEKQQDDHAELEEEEVEKLVEVTDFKPTTSEEMLRLYFENPRKSRGGDIEAWEKDIKSGAIRIKYSDPSVAKAVTERAHKVERCNLSVRLIVKKKPRPRPVKKRCLFLSGIPDECSLEHLSLYLENCSGMDEPRIQYGEMPGTALCTFPQDIPDFQKVIKKISSKKLQKAQVTAEVVLESDCILVQGLTKEVSLELIELYFDNKKSGGGGVKKVLQVNAKDKAIVYFEDWNVVGEVLSRKEPHKVSNTLLTVEEYHDCLGRLTSLDAPTPHIPKPISVMVPINIMEFIYRKGQETKKKLVEELRKVNASLTWPDGDKKMAARLEPLVGDGQPPSVWINWSQLCREALASFLDGCMSKTVPVPTLLWKEATAKLAKISTSQTCSVVLDSPTHSVRLVGEKRGVDEVVTDIKQVIKELQAKAYRDAQQTKQEIGLTVHKVKLLVQCGVRQRMEQRFPDLKITVKSTQGKEAITLEGKNKNVKEANLLMQKWMNELSSVEFKTGKTKTEFVRNVNDKVHEIWRKQRISAACDISEDKKITVYGATREDTHQAKKFIEDRIQDDTISINGRAVAVALKCQSGLQLIDGINQKKLAVVNVNYESGCLELAGFRNELKETKQCILSFFKDTVRMKDAIRTSRSKVRLIDSFHRHEVTNFTAKRRKDDVIIRPQMSGPSKGFLLESNETGLDAARKFITQLLAKIKEKRYPVSKIGMAQLFRETKGKNFLKSVEKKLKCVIDIVGDEEDDIEEGSNASQSPGTTEVLCKITLPDGCTLRVCKGDLTKQIVDCIVNAANEDLKHIGGLAGAILQAGGKIIQTESNQILKHKGRRLSVGEPVCTSSGKLPCKKVIHVAGPRWSQWPKRNTPEPRNEPTNEESLLFRGVLACLKLADELGFQSIAIPAISTGVFGFPVHLAAVQIVDAVAEFCQKKPNTSLTEISLTNHDQPTCNAMRRVVMDKCGHLFKTEPTPDNVTGARDASTSTDETAAGTMLFTSTGPNILKTREGVTVTMKKGSITEEQADVIVNSSANSLNLDAGLVSRAILEAAGPDLQRECNEVIAARGNISAGSFVETGSAALSYCKKIFHCVLDGYHSNTSGKSLATLVQSLLKQAETLKMVSMAIPALGTGNLNYPPDVTARVMYEAVVTFSSQHPNAVLKDIRFVVYDKDTKTIKGFEDEIERLTSGAVRGAAAPAFTQRRLKKAVSTSALEKRNSLSPMIRDSTGVLHSKIGPVCLQVCQGDLVNETSQAIVNSVGQKLGLQGPVSTALLAAGGDKIREECDAHRAKDPTKKLHVTSAGELPCDLIFHVVTPTTPAEVKDAVAKTLHEAEERKVKSISFPALGTGYQLGQAVASLASAMLAAIGEFACREPKPRHLQLIRLVIFKPEMFPQCEDALKQGGRSYTDKTSLLSKGTDMTKSLMPGAATDETSTDKAPDETILLQIFALDQATIQKATDKIDKFQSEEFTSEDVPDKLGMITKMTEEEQAELKIIERKYKVHIELLKQQAKCIRVKGLKINVKDARYDIQELFTRMQVQETEKQRSKHLTKEVQWKYYTPTGVEDYDADINTIIEDAYQKKQALVTIDLVDGQITIDFSKMQELSKDGALTVSRVDLLQAAKFETPSTWIPMKKKEHFRLVPLAIGTKEYTDVETGFQLSMGRQAVQITQILRIQNRELLMQYQARRTALEARLGRTNIEETLYHGTDEQTCDKINKFGFNRSFCGKNATMYGNGTYFAVEASYSASSSYARPNASNIKHIYATKVLVGDFTTGCHGMLVPPNKPNNPDQLFDSVVNNTNSPRIYVIFHDAQAYPEHLIKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YV58</accession>
    <name>A0A8B7YV58_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (34-2'-O)-methyltransferase regulator WDR6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982472</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096572.1">
        <property type="nucleotide sequence ID" value="XM_022240880.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982472"/>
    <dbReference type="KEGG" id="aplc:110982472"/>
    <dbReference type="CTD" id="11180"/>
    <dbReference type="OrthoDB" id="5594999at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1103"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1103"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022096572.1"/>
        </source>
    </evidence>
    <sequence length="1332" mass="146066" checksum="BAB70EDE6CEACF94" modified="2022-01-19" version="1">MEITTAAVLAPVTAIEVHKNYILSGEASYLHVYNLASGKHLEWYCLLGAHVIHGIRRGEDHQYAVFGQKAVCVVLLELGENVRLSVLCELAEFPDWILDVALLGKDESPSPAACLGLILAHNSAMLWDWKQKACLQHIHSAENCILYSARLLGSTWDDMTVVAGTVFNQVVIWKTTGPRDTEGRVPVERRLTGHQGVIFNLSYHRGRKLLCSVSDDRSIRLWHLDLGKPPAEQSGAVHRVMYGHSARVWDAKILDQFIASIGEDATCCVWNDTGEVIHRFTGHKGRSIWSLAVDETQQVIVTGGGDSSIRIWPIGAKQEENFTTEELHIWTDAVPVLLKGDPLASAGPGHGLETLTDAEGFNPRQLAVLNSGKIIILTLNGCLLCYMLRSKQWQLLSHDPNYQSYCLLSVCPSHQVAALGNIQGSLKIVALDCGLALVELPVFTGKIFSLCWQNEDNIFATGPDGVVIWYKADKSSKAYCLVEAARFLLPQAPQRWLTTVTLVPNQEGALVCGDRRGSVLLYTNLHRTRPEEKLVGPTHSLPCIHGKSGVTHVCYHAGCIYSTGRDGMYRQNRLQGTRLEMMNTCKVYKGFEWIENISFTAADDVLVCGFHASSFIVWSHKSNEKLIQIHCGGGHRAWSFANCEPPLTQGESSTHGDTVARKDGTCGSLAIFACIKTKKVIVCTAPGEKLQRHPTLKESLHGRRITCIKFLTTVSLPDGECALCATGSEDNAVNLVAIRFPVGEPSTLQILHRLQVHISSVRCLAACPSSFAIDPEGEPLEQGEVTGGQEAGQRLLLFSVGGRRAILCWRLTLPQHCPLQDQASVLLKSMCTVEHLMSYGNTDNVKQRRWLKRHGKPVDPETRFMSASLWKGNKVVGYSRTECILGVAGSDAYLRLFVFNEQTREMTPLVSTNSQGCCLLATLGITLDFPWGLCPVLLTAGTNGRIVFWDIQKALRECSADCTEDSKLAKSELNTNDKSKIEVLETNQQTGAISRELSRSMKEQCSNTKMSASGKDLCSISKEAKVSIKERCDSNAEPSSDDVGACSNTTAQCRNPKEQFSNTKELFSDTREPCSSTRDSCHHITTDTDQTSSTWYTLPPLSKKEREEPGTIQKHQDMQRTKPLASQKELGALAMNLTETDSSGDSEDGFRQSLLSIEAHQSGINALCMSQLDGNRFLLASGGDDNSIQLSLLSVSAESDRNIRVSVEHTHSITCAHAAQVTGLCFTDVCTLVSSSIDQRLSVWSISISPDKTSILKVKQFGSSFTLIADCAGMAHWTLRHAGHVIMVCGQGVQVLHLKESEGTRPGTCSLPSYDHHGVGSISDKLSTSGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YV75</accession>
    <name>A0A8B7YV75_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Defense protein Hdd11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097203.1">
        <property type="nucleotide sequence ID" value="XM_022241511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YV75"/>
    <dbReference type="GeneID" id="110982820"/>
    <dbReference type="KEGG" id="aplc:110982820"/>
    <dbReference type="OMA" id="PPCDEGP"/>
    <dbReference type="OrthoDB" id="6418377at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF45">
        <property type="entry name" value="REELIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034448611" evidence="2">
        <location>
            <begin position="20"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="3">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022097203.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="23792" checksum="DD3C1945827740B5" modified="2022-01-19" version="1">MALRCLMILFLSTTLGAWAFTAGPPVGQYPYDLCMNMIPSGHGESTATTEAPYRILTSSSTYSSGQSITVTVESTDSTSEIEGIFMQARRKGADRHGTKAIGTFSNAPTRTQLLTCGRPDSAWGHSGELGATAASVTWIAPPCDEGPLAFMATIVKGPKELFWTGVLSSEMTFTGPNSTDCGRPPASPMSTKPASTPSSGGPNGPLMSAMTLMMSVAVALHLDLVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWP1</accession>
    <name>A0A8B7YWP1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110983098</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022097738.1">
        <property type="nucleotide sequence ID" value="XM_022242046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWP1"/>
    <dbReference type="GeneID" id="110983098"/>
    <dbReference type="KEGG" id="aplc:110983098"/>
    <dbReference type="CTD" id="2645"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24019">
        <property type="entry name" value="ASKHA_NBD_HK_meta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000001">
        <property type="entry name" value="Hexokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000095">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="38"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="239"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022097738.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="51319" checksum="E7B097B080E9A7E2" modified="2022-01-19" version="1">MASSGTPKWVNVGGRWIRATPASNISEKTVSTKSTKNEVDEILQKLALSNAHLEEITSLMRQNMDRGLDSATHQSAIVKMFPSFVRSLPDGSEKGDFFALDLGGSNFRVLRVQLLEGDVQMTSKVYKIAEETMTGTGDQLFDYIADCLSEFKKEEGLGDVDLPLGFTFSFPCKQNGLASAELVQWTKGFSASGVVGKDVVQLLKEACVRKNVNLHIVALVNDTVGTLMSCAYSRSDAYIGLILGTGTNACYLEKLSNVGTWTGDSGEPTNVIINMEWGAFGSDGALDNFRTEFDKQVDEVTPNKGKQLYEKMISGMYLGEIVRLILVKLTTDGHLFGGKVSPDLNTPWKFETRFLTDIESDTSSDNGECRTILTSLGVTPSVSDLATVRRICEAVSTRAARLAVAGLSAVIRKMGAGELTIAVDGSLYKKHPTFKSNMEATLQELVPGVTIKLMLSEDGSGKGAALVAAVAARISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYX8</accession>
    <name>A0A8B7YYX8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metabotropic glutamate receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110983086</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022097705.1">
        <property type="nucleotide sequence ID" value="XM_022242013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYX8"/>
    <dbReference type="GeneID" id="110983086"/>
    <dbReference type="KEGG" id="aplc:110983086"/>
    <dbReference type="OMA" id="XCENILT"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034611421" evidence="11">
        <location>
            <begin position="16"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="561"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="560"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022097705.1"/>
        </source>
    </evidence>
    <sequence length="847" mass="92888" checksum="BF1A97A29F12E252" modified="2022-01-19" version="1">MILSLLLIFLSTTFGLSMSGIIPEAAHISLNSPGDVILGASFSFHTYSSPNLPACSGNVLTYGSECAALVLYTIDSINNRTDLLPNVTIGYDIRDNCYSEAVSLWSAFGLASTSEKPQEDIQFTNILGTAHGKLIGIIGTQSSSTSIPTAQAASLYRVPVISPFATSNELSNKRRFPYFLRTVPPDSLQASAIVDILQHFGWKYIGLYFQLSAYGIHGAQGVLDLTEERDICVAFSVALRTEAQTGELEEAVAKLAIFRKARVVVIFGDTGIANRIFRTIASKEDIASLNITFIGSDGWATPGSLLEYGVDLALMHGTIFVNLVYKVVPGFHDYYRFLLQRSGKASIPWFEDLKRHIINKYDCSDFNQCPMKIYGNAPFIVDAVYAFAYALQNFLTDRCNNSDDCNATLQALYGHDLLPYLHGLKFEGLVSNYSFDSDGNPSGKYGVFNFQFKGNNDYEMAELGTWDALAHNRLNINTSAIQWADGTLDPPVSVCRDICSSGYIEVPLEQKCCFGCQRCPDEAIVSDKKCKSCSVDEWPDENFEVCQPIVPTPPSWSEPTVIAVLILSGFGLFLSLLAAFGIYYYRGHVLIKAASRELSSINILGLTLAFLAPFPLLVPPTAVSCRASEIIITLCFTLTYAPTLLKVNRIYRIFDAGRKSNKCPRYIGPKVQLIFALGIVASMVVVAVAGALANPTLPAKLYFYPRRNYIEVFCQFGNGFLASLVSNLFLVLACCYYAFKARKVPSNYNESRFIAISVYSTLVFGMAAVPVYITATTVLQKVATLCVAILLNAFLALFCVYLPKLYAIQLDREVEVSEWRVSNTGLSGQTTSTAASASCGRAKVQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZL0</accession>
    <name>A0A8B7YZL0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WASH complex subunit 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110983660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098788.1">
        <property type="nucleotide sequence ID" value="XM_022243096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZL0"/>
    <dbReference type="GeneID" id="110983660"/>
    <dbReference type="KEGG" id="aplc:110983660"/>
    <dbReference type="OMA" id="RCNIFIQ"/>
    <dbReference type="OrthoDB" id="10261210at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028191">
        <property type="entry name" value="WASH-4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028283">
        <property type="entry name" value="WASH-7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028282">
        <property type="entry name" value="WASH-7_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027307">
        <property type="entry name" value="WASH7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31409:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14745">
        <property type="entry name" value="WASH-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14746">
        <property type="entry name" value="WASH-7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14744">
        <property type="entry name" value="WASH-7_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH complex subunit 4 N-terminal" evidence="3">
        <location>
            <begin position="31"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 central" evidence="2">
        <location>
            <begin position="600"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="WASH complex subunit 7 C-terminal" evidence="4">
        <location>
            <begin position="962"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022098788.1"/>
        </source>
    </evidence>
    <sequence length="1183" mass="136518" checksum="4B2252C8478BFED0" modified="2022-01-19" version="1">MAAQAKQGWDFDKFDDGSLKIVGEVQLKKYGKFLEDYATQLKGIEDALDSSIGDTWDFTLDPISLQFLPYEQTNILELIKTDNKIFNKVITVFASLCCEMNTLKHEAEIKFYPGVMFYGEGEPETGLEEGEAQVQMGRMMPFMQELSCFINRCYEVVRSTVHQLASLYNNSKTAPKIIDVTHVHFQTVYEHLGDILRVLITLDEIVANQSTLKDHWTLYKRMLKSVHHNPTRFGVEESKLRPFERLLMGLQGQLLDGMIFQNCVEQGFDNNSVLVSKNSFFAEEFAFNIRNMFTQVDPKIGEINEINQRLQYVGICGLYVLHFQIFRVIDKKMFKSLWDVYRRVPAITLTANIVWSANQFLLRSLSPHIARLLDKKSQQSVMQTTQAFLQQKSQSLVREVQVYYMQVCSWMIKMESSLTSANTVMEDLTHKCNLFIHGLLFAYNISNLVRTVMNLHAHMNKPMTKTAVLALCRLIEMLKSIEHTFHRRTMLVAESITHIIQYLQFTSLALVNGAKKRIISDKKYSEKRLDALSALVLVENALSGTATKERKLIANLALHVGTQMKAFKEDELASYRTTMNKLFLISDLREKLREACDCSFLYWHRVVFPLYLADRFENAVDAHRLHYMFGALADCVPPITQSKHLESPQQLLDSFEKETNAQFKEHLLDPLCRGVETDLRLSIHNHLQLDSRNPFRVPLQDVSHFIKMRPIRFFNNFLDIKASVTHYLDKTFYNLTTVALHDWKTYAEMRNLASQKYGLTMTEAHLPTQTLEQGLDVLEIMRNIHIFVSKYLYNVNNQIFVERSSNNKHLNTINIRHVANSIRTHGTGIMNTTVNFTYQFLRKKFFIFSQFMYDEHIKSRLLKDLRYFKENKGDLHQMYPFERADKFNKGIRKLGLTPDGDSYLDQFRNLISQIGNAMGYIRMIRSGGLRCCSNAIRFVPDIDDIVQFEELVSEEGLSEEAKTAAKNLDGVIGNLTKNFAEGTEYFKMLVDVFAPEFRSSKNMHLRHFFMILPPLTLNFVEHAINCKDKLSKKNKVGAAFTDDGFAMGVAYILKLLDQYNEFDSLHWFHSVSFKYKKEKEGVKKQQANDEKLQQTVSLTIKRLDTYQREFDLLYYSLSSARIFFRADKTAAEEQEETKEKEKEEVAAGEAESSNQQAALPETPSNQAAIQAPPQASLPAIMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1B7</accession>
    <name>A0A8B7Z1B7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110983647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098762.1">
        <property type="nucleotide sequence ID" value="XM_022243070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1B7"/>
    <dbReference type="GeneID" id="110983647"/>
    <dbReference type="KEGG" id="aplc:110983647"/>
    <dbReference type="OMA" id="VACIEDH"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017865">
        <property type="entry name" value="F-actin_cap_asu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00748">
        <property type="entry name" value="F_ACTIN_CAPPING_A_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00749">
        <property type="entry name" value="F_ACTIN_CAPPING_A_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022098762.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32654" checksum="B47F9001BB3B3AE8" modified="2022-01-19" version="1">MADLEPISDQEKVRIASSFIRHIPPGEFNEVFNSVRTLVNNDKLLKDQVVDAIAQYNNEQLTPCKVDNEMVLITEHGNVGGNRYVAPNLKKSFKYDHLRKESSDIDSHAVNEMAEPWRAAMDKAIIAHVKDHFPNGVHTVYGKSDGDAVTLIVCIEDHKFSPHNFWNGRWRSQFSTTFTGPGTKAEVKGIMKTQVHYYEDGNVQLVSHKEIKEQISISDEAATAKAILNVIEKAENDYQSSMVDDYKVMSETTFKALRRQLPITRSRIDWNKISDYKLGQELKGAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2Y4</accession>
    <name>A0A8B7Z2Y4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110984276</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099984.1">
        <property type="nucleotide sequence ID" value="XM_022244292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2Y4"/>
    <dbReference type="GeneID" id="110984276"/>
    <dbReference type="KEGG" id="aplc:110984276"/>
    <dbReference type="OMA" id="QADGENW"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="359"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022099984.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="58705" checksum="E7C8B3BB3FD02C0F" modified="2022-01-19" version="1">MDDVLVTGATPQEHDTRLHHVLRVLQGAGLRLNKDKCKIVQEQVNFLGHRLGKDGIHPDPAKVDAILQMSPPTTKEEVKRLMGIVNWLSRFIPHAASTAAPINDLMKDDTEWTWGPAQRTAFRQLKTLLTTAPTLAYHDPRKPTMVSADASSCGVGGCILQKQTDESWKPVAYCSRSLTRAEQRYAQIEKELLAAVWSCERFYIYLRGLQVTLQTDHKPLVSLIDQKDLCDAPLHCQRLLMRLMKYNCYAWPATDAKLVEIAAAVSHDRTLTAVISFVKDGWPKYQKDVEPELRRFWEDQDNISLVGGILTYGDRIVILQSLRRQKLQRIHEGHQGISKSRLRANQALWWPELRHLHTTTAKSVINFMKATFARYGIPDVVLTDNGPQFLGEFDQFAREYNFQHLTSSPHYPQGNGQAEKAVHIAERLLSQDDPVRALMMYRSTPLPSLGQSPASLLMGRESRTNLPTLPCNLQPKQINYDKLRSADTVNKSKSACNFNRRHGARDLDPLTPGDRVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3Z2</accession>
    <name>A0A8B7Z3Z2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Hyalin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983259</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098071.1">
        <property type="nucleotide sequence ID" value="XM_022242379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3Z2"/>
    <dbReference type="GeneID" id="110983259"/>
    <dbReference type="KEGG" id="aplc:110983259"/>
    <dbReference type="OrthoDB" id="10064599at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="955"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="121"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="209"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="298"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="384"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="469"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="552"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="637"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="720"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="10">
        <location>
            <begin position="805"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="885"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="579"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="917"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098071.1"/>
        </source>
    </evidence>
    <sequence length="1073" mass="114558" checksum="8ACF07944082E66D" modified="2022-01-19" version="1">MPRVLSSKSTLLGVLTGVTLLVSFKLADASTFALIADLENGTIYRGYLSQNLADLTPLPLNGVMRPVAVDYDPVEGMVYWTDQRSESAPKICRAHLDGSNQTTVVGDLTDPGGMALDVASRMLYWTDGALAHIGRARMDGTGSKEILLSENHYNPKGIVVDSVHGHIFWSDWGENPRIERADLDGNNRRIVVQGGLSYPSSVTIDFNGNSLYWIDAIHDTIETSDLSGSNRRLVANLTVYSLSFPFDLAVYGDYVYWTEWGMYPTILRVHLDGRGAETIGPSIFQMPGGIHIQEEEEVDSTPPVVTGCPNEGVFKAVPLGYTSANVTWTPPTASDDSGMASVTMSSNRVPGQSFNLGRTHVQYNFTDAAGNQAFCDFVVTVSAVDSTNPTISCPPTIVRYVRSATQQLPVSWQFPTASDDSGNQPTITSTPNYPTSSGTFGAGMHSVTYLARDGAGNQASCILTINIILDSRIPTITGCPGRTIAVLPPGSSSVAVSWTEPVGADDNGVVNMTRSHRPGNTFTLGNATVTYTFTDQAGNQATCRFTVSVSRGDVTSPVISCPPTIVRYVRTATQQLSVSWPSPTASDDSGIQPTITSTPNYPTPSGTFGAGMHSVVYSARDEAGNQASCTLWINIILDSRIPTITGCPGRTIAVLPPGSSSVAVSWTEPVGADDNGVVNMTRSHRPGITFTLGNATVTYTFTDQAGNQATCTFTVSVSRGDVTNPVISCPPTIVRYVRTATQQLSVSWPSPTASDDSGIQPTITSTPNYPTPSGTFGAGMHSVVYSARDEAGNQASCTLWINIILDSQAPTMAGCPGTTVVSTGNRSVDVSWTEPVSIDANGVVNMTRSHRPGDRFAVGDTFVRYTFTDRAGNQATCTFTVRVVAGCLLTPDQFDHLEVVSGQQSVYLPGESVQLTCQDGYQLSGSASRFCRSDLTWSGEPAVCVQQGEPMGGTVVGFGAGASGVLLLILLLLVVIFLIRRRKKTRVRAPDLAITAQITTQGDLGIYDNPQPVYETVVRGAAAPPPKEEETALSEVKPPLPSTPTPGYPPPSYEYAHADRHNYNLPPTYIPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z449</accession>
    <name>A0A8B7Z449_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110984483 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110984483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100409.1">
        <property type="nucleotide sequence ID" value="XM_022244717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z449"/>
    <dbReference type="GeneID" id="110984483"/>
    <dbReference type="KEGG" id="aplc:110984483"/>
    <dbReference type="OMA" id="CKHTERT"/>
    <dbReference type="OrthoDB" id="5971311at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF14">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT FE(2+) 2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022100409.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="30226" checksum="4374C8927F9429DC" modified="2022-01-19" version="1">MIGTVVICLPCKHTERTLTVEHKGVKEKFLFANLSNDQSKIQWAAFYSDCVHEIVPVEEGSRITITYNVLKQEEDSYICEYGLCQRQSFSTGPMVAADNKSTLDNIVSDVSNISAKVKRASYEHLGIFLQHRYTMAALAAGNLKGCDQVLYEGLQARGLPCHPLTVLVHQIENPDEEDCFEETRDVFLLSQEVMDYVKKNGPRPSLPFPGQALFIREWTEETFLISEETTEAEYCGNCTEGGETESLYLQSALVIGTPEQGKAKGGPSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4M3</accession>
    <name>A0A8B7Z4M3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099735.1">
        <property type="nucleotide sequence ID" value="XM_022244043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4M3"/>
    <dbReference type="GeneID" id="110984166"/>
    <dbReference type="KEGG" id="aplc:110984166"/>
    <dbReference type="OMA" id="WIRYRME"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="181"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099735.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="41453" checksum="19EC3902081E5043" modified="2022-01-19" version="1">MSKPSLCIFFDKVGAVYSRDDIISGKVKVKVGNQGLENIKGVWIQFTCTAWVKISSSYDNEDHEQRHQYLNSTLCVFGARKSESAKPGLTLSAGDHSFPFKFRLPNDKPLPAPFEGVHGYVRYRAKATLCINRVILNKEHSTERAFSMHGPTVDLNSMPRLNLKAPVSCRTDVRNLFGLGMTTGTDVTFCLPKRGYIPGENVIVTGHVNNASGKEQRNIEVALIQETTYRVKEFLVDATNVHNRRLSRSFGSVACPQGKVTPFRMKALHIPPSVPASGMPGCQMINVQYYVKCNTSGCIETLFRLTVGTVPLRDVAAPAVPPAVDAIPSAPQLDKANTGAHQIPCPPVVNGLASRFDDAPPTYEEAIGSRTTLTNGVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6J7</accession>
    <name>A0A8B7Z6J7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein phosphatase 1 regulatory subunit 21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Coiled-coil domain-containing protein 128</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ferry endosomal RAB5 effector complex subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">KLRAQ motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110984932</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101268.1">
        <property type="nucleotide sequence ID" value="XM_022245576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6J7"/>
    <dbReference type="GeneID" id="110984932"/>
    <dbReference type="KEGG" id="aplc:110984932"/>
    <dbReference type="CTD" id="129285"/>
    <dbReference type="OMA" id="XFSQYLH"/>
    <dbReference type="OrthoDB" id="5566667at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040024">
        <property type="entry name" value="PPP1R21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049372">
        <property type="entry name" value="PPP1R21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019343">
        <property type="entry name" value="PPP1R21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019348">
        <property type="entry name" value="PPP1R21_six_helix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21448">
        <property type="entry name" value="SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10205">
        <property type="entry name" value="KLRAQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21636">
        <property type="entry name" value="PPP1R21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10212">
        <property type="entry name" value="PPP1R21_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01254">
        <property type="entry name" value="KLRAQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Protein phosphatase 1 regulatory subunit 21 N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="154"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="713"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022101268.1"/>
        </source>
    </evidence>
    <sequence length="796" mass="89995" checksum="22FB21F4EBEF190F" modified="2022-01-19" version="1">MADLQTKYQKLAQEFAKLRAQNQVLKKAVVDEQEKQNSLKDNLKEKDQKIRKFEQELDSLTFRNQQLTKRVNVLQDELEAAEGKGKKNKSREADHGMSNRAALPGVMNEELQSKIKENERLHKQVYETTQSHQQAMMQLQDKLSTLESLSSQHQNVLESSAKKHQETVERLQQEKAMLEVKLQAQEKEARESIQKAEESTQKLGVLEEELGGKVAWMTHIIQTKLPFNDTEKRELNALNVPTHDRKHQVSSVLNMEKCSHDRHELCAGLSNLHTYTEQRSKIFPVDSTTGPISAVNQKFCSYLHENASYLRPVEQAFKNFLDNIREESLTTLETATELQDFSAKFSKYIAYLEKLLPYQLLSLEEECALSTCPQTLESRNMELHASFKKLTAALAKLDTYLAVLAAVSTQSCDYPQANHRMFFEKLSECCQNLSNVMKDVSKNYNFKVSLEHQLPTASQKLRTTDECVVSSLISLVTCTGKIANFTKSNLEFLSTPPGFRTRGHTFIGTSQFEGAISSPAVTALRQKAVNYMTALSKPCPDSVPYERALRNQRILLSSTESQTGLAQQLAKTSEKMSQLEQDREHWKLEAQLVQIKLTKESQKCVVLEAELKRLRSGGKVTSPIDQESMVAQAMAKAVEVDTIPSRAPAKGKTEPQVDTSMLGQLEGITMDFGESDETSRENLIKSHYTTRLAQLTAQRQVVDGKVVNFSSECRALQKRLALAEKAKEKHVEELQTAHKNVTQLQDELQTTTRSYESQLSMMSEHLCSMNEKLTAQKDQIDALKLAAKPNKKGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7D0</accession>
    <name>A0A8B7Z7D0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18 19">Potassium voltage-gated channel unc-103-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18 19 20 21" type="primary">LOC110983883</name>
    </gene>
    <organism evidence="16 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022099209.1">
        <property type="nucleotide sequence ID" value="XM_022243517.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099210.1">
        <property type="nucleotide sequence ID" value="XM_022243518.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099211.1">
        <property type="nucleotide sequence ID" value="XM_022243519.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099212.1">
        <property type="nucleotide sequence ID" value="XM_022243520.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099214.1">
        <property type="nucleotide sequence ID" value="XM_022243522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7D0"/>
    <dbReference type="GeneID" id="110983883"/>
    <dbReference type="KEGG" id="aplc:110983883"/>
    <dbReference type="OMA" id="KFQNTHT"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000123">
        <property type="entry name" value="Potassium channel KAT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.260:FF:000001">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000107">
        <property type="entry name" value="Potassium voltage-gated channel unc-103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003967">
        <property type="entry name" value="K_chnl_volt-dep_ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF548">
        <property type="entry name" value="GH12235P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01470">
        <property type="entry name" value="ERGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="15">
        <location>
            <begin position="393"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="550"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="681"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="756"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="834"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022099209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022099210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022099211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022099212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022099214.1"/>
        </source>
    </evidence>
    <sequence length="957" mass="106198" checksum="2AD34DA42933F91A" modified="2022-01-19" version="1">MRNKGLQLEKSEVIRLTSDEINHKKLRSRKLHNYTILHYSPFKAVWDWFVLLLVVYTAIFTPYAAAFLLNDDERRAKLNKEAETRAGEGLSSSYTEPLVILDLIVDIMFIVDIFINFRTTFIDDVKGEVVSDPAKIAKHYLKGWFVIDVLAAIPFDLILFGLANDEKTTTTMGLLKSARLLRLLRVARRLDQYSQYAPAVIFLLMCAFTLVAHWMACCWYSIGEGERDLDYGWLNQLSRDINETYREDDTGGPSAQSKYVTSLYFTLTILTTVGFGNVAPTTDVEKLFAICMMLVGSLMFACIFGNMTAIIERLYEGMARYHQQLTLVKEFVKFHNVPHPLRRRLQEYFKHAWVYSNGNDLQEVDEVMKDFPDFLQADISLHLNRNLLNGSPAFKGVEHGCLRALSVKFQNTHTAPGDILLHRGDSLNQMYFISRGSLEILRGNVVLAILGKNDVVGENFCQRPLVGRSKGTVRALTYCDLLTLYREDLMDVIKMYPDFREHFAEKVEVTIDMRDTELDKIVPDIAPKMNHWPSTKTVLNRRFSAVVAAAQAARKSKEQQQQRSGQGGGAGGGGSGGRVELTPCPSTETVASKAGSEASCRDSAFTFQSGKWKRKPSKINTVVSIETKDDEDKDESDPEVPLMQRKYRHYTEPHQRGSKTAEQKHSLVRDAHRSVEKAVALSSLGNREAPEGAVTASLPSVSPRAGAADPDNNNVGYFVDNNAIHSRIDGLYTQLGAIERKFDEQKAAIIECLIGKSRPGGREGRPAAYLGTHPVGNTRSMDRRPDDVSGPTRDAAGGDPNSGPTLDKQKQDPSYSNHSDHPLIELGVATTPVANALGGAPPEGTARTASDRPKPVVVTSSSLPPQQDSRPPEASEKLPQLRTKNFRQRGAGPGRSRGNGRPFSVPGRVSMGSRSPNARAPSLTFPVLKGEDESGEVIWLERRGEELSGSRISSTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7I4</accession>
    <name>A0A8B7Z7I4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Helix-loop-helix protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110983909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099266.1">
        <property type="nucleotide sequence ID" value="XM_022243574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7I4"/>
    <dbReference type="GeneID" id="110983909"/>
    <dbReference type="KEGG" id="aplc:110983909"/>
    <dbReference type="OMA" id="EPREISC"/>
    <dbReference type="OrthoDB" id="10067827at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19701">
        <property type="entry name" value="bHLH_TS_HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000027">
        <property type="entry name" value="Nescient helix-loop-helix 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040238">
        <property type="entry name" value="TAL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864:SF10">
        <property type="entry name" value="HELIX-LOOP-HELIX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13864">
        <property type="entry name" value="T-CELL ACUTE LYMPHOCYTIC LEUKEMIA/STEM CELL LEUKEMIA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022099266.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16421" checksum="0E33056FB0E31ED0" modified="2022-01-19" version="1">MRATRSSMPSMVLPLPAAVKEEPREISCGAKLEAKLEARQNENMSSTTTAATTNSNTTCRGGVAQHQRSEAQLSREERRRRRRATTKYRTAHATRERIRVEAFNVAFGELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z857</accession>
    <name>A0A8B7Z857_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110985254</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101848.1">
        <property type="nucleotide sequence ID" value="XM_022246156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z857"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein-lysine 6-oxidase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
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        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050912">
        <property type="entry name" value="LOX-like_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817:SF4">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034183998" evidence="11">
        <location>
            <begin position="25"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="93"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022101848.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="54204" checksum="23557A1ED4D069B9" modified="2022-01-19" version="1">MGKISGLVVLLLAVFITGASNALAKEGPKGKSGELKDGKRAPKDAPLKENRAPRYYTEQPSYDCSSYEWQCYYNGQYSNCYYGEDESYCNVSVRLVGGSSSKEGRVEVYYQGQWGTVCDDHWGVADANVVCRMLGLPPATDAWRNAHFGQGSGLIALDDVNCRGNESSIAECQHRGWFSHNCGHHEDAGVTCGEAPVHNTDSPPCYTEEPSYGCSPYEWRCYYSGQCIPDFQRCNGYSNCYYGEDEYGCYGYHTESPPFNTEEPSYGCRSYEWQCYYNGQCIPDYQRCDGYSNCYLGEDEYNCYGYYTEGPSYFTEEPSYSCSPYEWRCYHNGECIPDYQRCDGYSNCYYGEDESDCNGYYTESPSYTEEPSYSCSSYEWRCPFTGQCIPDYQRCDGYSNCYSGEDEHHCYETFRCSDGTEIPQAFTCDRIIDCRYGEDELQDCRAFHSKRDETELNPRLEQLLAKRRQTDDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9F4</accession>
    <name>A0A8B7Z9F4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamic acid-rich protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101587.1">
        <property type="nucleotide sequence ID" value="XM_022245895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9F4"/>
    <dbReference type="GeneID" id="110985118"/>
    <dbReference type="KEGG" id="aplc:110985118"/>
    <dbReference type="OMA" id="KREGTMA"/>
    <dbReference type="OrthoDB" id="5974215at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022101587.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22454" checksum="67CE8550EC7376CD" modified="2022-01-19" version="1">MADSAPKLARDSTMNVTAKEGVEFLKSQGADHLLPEDPDKPEVQRDTTIQATVKESEAILKDANIDKDARTRGEQQRLQEISEETKVDDPPRVPRDHTMKETAKEAQELLGDAPIGETRSQTRDITKAAAEEEEEEEEEEEDEEEEEDDGVEDGNEEEDEEVTSLKRTHTMAETMQEGQEFLKRQKTNGDVAKKDAAEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9G1</accession>
    <name>A0A8B7Z9G1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein WDR12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110985536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102309.1">
        <property type="nucleotide sequence ID" value="XM_022246617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9G1"/>
    <dbReference type="GeneID" id="110985536"/>
    <dbReference type="KEGG" id="aplc:110985536"/>
    <dbReference type="CTD" id="55759"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="147"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022102309.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47852" checksum="AABC02387DB54383" modified="2022-01-19" version="1">MATKLDVSGYGSHLQAKFVTKQECYAVGDSPFSVPASVEVTELSALINKLLSREESEDAVAVDFDFLINGEFLRVALGKHLEEKSISTESVVEIEYLEKHPAPQPAGSILHDDWVSSVQAANHRLVTGSYDNAVRIWTQEGENLAVMQYHSDPVKTVAWIQTDDSESLLVSGSMDQTLLIWKWNEKTQKHECLHSCRGHAGSVESVAVDQSHTKMASGSMDSMLKVWSAVPGDEDEEIDAHHKKAKTETHKPRTRTPLRTFDGHTQGISSVVWVDEGSVCTASWDHTMCLWDIEQGEQVSTLTGNKVFLSVSYSQHCKLLATGSTDRHIRLWDPRQKDGVLVKSSLTHHHGWVSSVDWSPDNENLLISGSYDKTLKLWDTRSPRAPLYNMSGCEDKILAVDWSKSELLLCGGADNALHIFKSREALQAVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAH2</accession>
    <name>A0A8B7ZAH2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Tripartite motif-containing protein 45-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC110985321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101962.1">
        <property type="nucleotide sequence ID" value="XM_022246270.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101963.1">
        <property type="nucleotide sequence ID" value="XM_022246271.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101964.1">
        <property type="nucleotide sequence ID" value="XM_022246272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAH2"/>
    <dbReference type="GeneID" id="110985321"/>
    <dbReference type="KEGG" id="aplc:110985321"/>
    <dbReference type="OMA" id="MECEYFL"/>
    <dbReference type="OrthoDB" id="5977875at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="104"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="167"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022101962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022101963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022101964.1"/>
        </source>
    </evidence>
    <sequence length="588" mass="65927" checksum="157528034D82936B" modified="2022-01-19" version="1">MASRITAESILRKISEGHLECPICSCRFSDPRVLDCLHSFCLRCIQQLRPCIDQHRRELKLTVACPLCRHQTTTMKMDSLPANFTLRALVEEVGLMEQLLEGQRQQIKCQNCTEKQQAIAKCMDCDLLLCQECKWAHNRMSVMKSHGVFTLAQLESGEFIYKSKLREEIPKCEKHPGQNLCFYCNTCEQLICTSCTVLDHKSTEHSLAGIPEALDKCIQDITELVTIAEQKKPQLFIAWAQNKLDDVHRIMGEASCYEILELKPKLLDNLRELTEHQPEKLSHTLLFTDSEDPQLVTDTGSDSQKKLFERSEADMCTNGKTSAGPREASVTQTWKLKTEYADFYNVNSSLTDIAMYSSGETVALDSGQRELISITPMGAQFSATYRCLHKKYLKKPRCISVNRQDQLLVLDGSMVKIFYGQYQQHQFTTGKGPDNEPTCIAVDDDNQIAVGYQKSEEITLHTMDGSPIRKVSAPMMGTCLTVSRRRFIYTSSKNNKLLALDCNGAMLFSIDTVPGTIGFRSVCCDRDGSIYTAVQESLFSGSILHFSPYGEHKGCVIRDCNGPSGIAFSGSGQLLVAATDCIQIYHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAW3</accession>
    <name>A0A8B7ZAW3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985412</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102112.1">
        <property type="nucleotide sequence ID" value="XM_022246420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAW3"/>
    <dbReference type="GeneID" id="110985412"/>
    <dbReference type="KEGG" id="aplc:110985412"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102112.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26221" checksum="BE596946351E27E9" modified="2022-01-19" version="1">MEKKAKHFVRLLARELYENEQTRVTGPVNIAAVKHAFRNALNDLPKSALKTELQRNAATYSRRLEALTKSARDDSSKSSRKGTNIEENEPKKQQESNNANTDDLRSSETKEKEACCQSKKTSDQKGLTKSTSEAVFSSFTHTEDRGNEERINDTVAMATPSEDKTEVADLEQGEASDSGSWSFAYNVYATDARSRVIESLAKLHSEKRQRLAPHAYASLCSTNSYFEFLQIPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC35</accession>
    <name>A0A8B7ZC35_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stress response protein nst1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102537.1">
        <property type="nucleotide sequence ID" value="XM_022246845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZC35"/>
    <dbReference type="GeneID" id="110985662"/>
    <dbReference type="KEGG" id="aplc:110985662"/>
    <dbReference type="OMA" id="QCLCCNS"/>
    <dbReference type="OrthoDB" id="10043348at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102537.1"/>
        </source>
    </evidence>
    <sequence length="822" mass="89848" checksum="DF98A280859AF9C0" modified="2022-01-19" version="1">MSVQSQRTGACKSDIDPIGVSPGPASDESAMTQTLNTGGEASSTSGAAADCSMATDSGGGEDSPRDYNKRKYHASKMDLNLKILRDQMANLTSSGSSLSRQLASMHRNIQEIKDDDDGEEADSEYESDDEQKPGNIRDAVDTEDDVNKMSDLEKDYSEPKLKRSVSTSSRSKKSKTGLRDPIANEATDGSQARRNGSWSNSRQESVESYPDSDSECSQCLCCNSMASYSSTPWRYISRGEGSTMDEESDSSEYFSDDSEYSTTTSNMPSVDIHKRLSPFYCPSDQAETGSRGDSEEGRFDDADHEPVVDHRMSPLGCESPRKSSSQPDLPSMSHKSDTMVVESDKPKPEEKVEEATGSQEDEKAVKASSLIGLFKAQESKAKEEEKASVAKAKRVEELRRKNSEIRIKNEQKRRAELEEKLKNKAKVDTVSPKTSPLVSENDDSEKVNVKDRISSFEGQKKTKDKEKTEEAGKKESKKSENVEKGTNTDPDSVQQMPDVIPDVTDEKISQELTEAQGDHDQHKSHKSKHHKIAKTTIEIPVSCLPEEITNPEPGMTSDQPTMMTFQVKAGDVEAMKGPILVSRSPKPKRKMSKTVVRLSSTDASPSSISESTLVPDTNTVRAASNKPSGHSHGVCPHCKKSKPGESKRVVKVLQLQPVPESPELPPIPDTNLAGNSAQVFQQQPGGRVIKMIPSKRPNVLQRQQSSEDGVVFRFNMGMPENAPLQVGDFIRIPIQPQQQYPPQQVTHVQHAGGGGGLVIRTGGPPRRHQEVITFRQSSSRPTGDIRVQQGQNPTSGVTVHTSQPGVRVMPSEGGGVRLVFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCB6</accession>
    <name>A0A8B7ZCB6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WASH complex subunit 2A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986046</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103329.1">
        <property type="nucleotide sequence ID" value="XM_022247637.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986046"/>
    <dbReference type="KEGG" id="aplc:110986046"/>
    <dbReference type="OrthoDB" id="751084at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905394">
        <property type="term" value="F:retromer complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036010">
        <property type="term" value="P:protein localization to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029341">
        <property type="entry name" value="FAM21/CAPZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669">
        <property type="entry name" value="CAPZ-INTERACTING PROTEIN AND RELATED PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21669:SF1">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15255">
        <property type="entry name" value="CAP-ZIP_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM21/CAPZIP" evidence="3">
        <location>
            <begin position="1131"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="254"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1110"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
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            <begin position="395"/>
            <end position="408"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
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        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="511"/>
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        </location>
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        <location>
            <begin position="546"/>
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        </location>
    </feature>
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            <begin position="565"/>
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        </location>
    </feature>
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            <begin position="694"/>
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        </location>
    </feature>
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        <location>
            <begin position="719"/>
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    </feature>
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            <begin position="736"/>
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        </location>
    </feature>
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            <begin position="778"/>
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        </location>
    </feature>
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            <begin position="857"/>
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        </location>
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            <begin position="1059"/>
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            <begin position="1151"/>
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        </location>
    </feature>
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        <location>
            <begin position="1179"/>
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    </feature>
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        <location>
            <begin position="1210"/>
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        </location>
    </feature>
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        <location>
            <begin position="1246"/>
            <end position="1256"/>
        </location>
    </feature>
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        <location>
            <begin position="1257"/>
            <end position="1269"/>
        </location>
    </feature>
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        <location>
            <begin position="1353"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022103329.1"/>
        </source>
    </evidence>
    <sequence length="1514" mass="162406" checksum="9A8A0B651ABEDDA3" modified="2022-01-19" version="1">MAPPPPPAPPPPPTGDLDDFLTNGLDGQPQNEGAVALPSFGAGDTNGSMDTMPPAPPEKEPQVWEKPLTIPDIRKSSNNWSLASDAGLLLYLQEFSHKMLAKTSDLEKKVDNLVHETKCTDSRVHNVFNDFLMLANTQFIENRVYDDSEETDQKPETTNKREEQVKTREQREAEVIPRVIKALNLGINVLDSAFEQLDANAGNSDSEEEDPTYRAVVEPILEPKDLYAHRSLPFLIGSPAFMQDDNVGVADITEEEMSEEGSVSGSEKTTSESESEYTDESETESEIESDVATKKKPSQIERSESENDLFEGEKLSDEEEEKPKGGALADELAARIGTAPQSKADDDETKRDRSISEVSGTSTSSKGKKRKKGTAKDKSGKRRSASKTSAVSEDNMFDEPAAAEDEDSPFSKKGGLFSSSGGGLFADDEEDEEGGLFDEAPKPRSASQRDDHIYEDITAEEVETSTESHNKVPAGAVPLFGDPSTEDDLFGSSPKSNEAGKTLFMRATSAAKERRSSMESSRKKKQQQKGEKKAPKEAGGGGGGLFDDEDDDDGLFAEPSASKPAKKEAAKKTVDLFGDEEDGELFGGSAAQKPAPAEAPRQRTDSKKKLPAGAVSMFGTLDPLAAKRASGDHEEEKEAVEEEKTTPPPVAKKKEPKPTPQKPGGMFDEEEGNLFAEQAKSSKPAPTKEKDPLFDDLDGEDTLFADKETVQVPPAAKTAAEDKPDMKKKPSGGLFDDIEGDDGDDLFGATSKPKETTKKKPAGGVALFGDADMFSTSPKKEETENAPVKKRDATPKSRNTLSLFDDDEQDNQLFGDGSPAKKDEPVMRHRTKSKSVFDDEDVLFNIKEEAPPVDLFGSTSPVSATKPDSNVDKPRSASSAGKNLFSDEEEDDLFDAAAKATPKSATKAPPAKKAEPSTKPRASSQVDLFGDDDDDSDLFGGGGKAKAMPEVKSKPAMPQVKSKPATPQVKSKPATPEVKAKPSKKKVGEDSSNSPTHSDPLFGDQSPPPTTAAQPKKPAGAVSMFGGVDPLAVTRQISQEFAREEQEAKEPKAEDKSSRSPSISSVSENISPKPFSAAATSSDKPASVIRSVRAPLAKAGGKRISMLQSNMAIDPTAMRPGATPPSREVEPEGVSFDEPPTLNTLSSLNKGRAKISTKRRAPSRRLRTEGATTAIPVSLSPSSGLLNTSSEPLPEERSPSSRPLDFSTGPLDTNDVTFPPVTSSKPKERDIPSSAPDFSSPLGIAPSQTTPSSVSVDSDKPKAKPRDMFGNDDLFSGSPEAALPAKIGEDDLFTPAPKKSERTKSPLSVDQDLFATGTKSQAVEKKPQSDPFEADLFGDGPESKKQKKKAGKAKAPAADTDLFATDTTKKNETKAPPLLDDDDDDLFASASPSKAKKKKDSKKAELDEDDLFATKKPATKKTKSKKPDADLFSDSTNIFDDLPSSKPKEKKKKQESSLFADPAEDDIFASPTSSKPKKTKAKRKATEKKPVTGDSIFDESAPSIFDDPLNAMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCG7</accession>
    <name>A0A8B7ZCG7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Probable Bax inhibitor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC110986057</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103354.1">
        <property type="nucleotide sequence ID" value="XM_022247662.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103363.1">
        <property type="nucleotide sequence ID" value="XM_022247671.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103373.1">
        <property type="nucleotide sequence ID" value="XM_022247681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCG7"/>
    <dbReference type="GeneID" id="110986057"/>
    <dbReference type="KEGG" id="aplc:110986057"/>
    <dbReference type="CTD" id="7009"/>
    <dbReference type="OMA" id="SRDFIMH"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034620">
        <property type="term" value="P:cellular response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033119">
        <property type="term" value="P:negative regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10430">
        <property type="entry name" value="BI-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF32">
        <property type="entry name" value="BAX INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022103354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022103363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103373.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="26472" checksum="2C7246221F6C24E2" modified="2022-01-19" version="1">MDALFGQRKIKLSALTDFSQLNKSTRTHLKNVYSCLAISMLAAAAGAYIHLFTGILQAGFLTSIAGLGLLIWLGVTKDDGTNQAKRLGLLSGFAFFTGLSLGPLLNIVARIDIQIIPTAFLATCVIFGCFSVAALWSERRSFFFLGGMLFSGLSILMLMSLLNIFIGSALIFRVEMYLCLAVFMGFVLFDTQLIVEKCNNGDKDYIWHSVDLFLDFINIFRQLMIIMAMNSNGKDKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEN5</accession>
    <name>A0A8B7ZEN5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110986512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the heterotrimeric retriever complex consisting of VPS26C, VPS29 and VPS35L; within the complex interacts with VPS35L. Interacts with SNX17 (via C-terminus); the interaction is direct and associates SNX17 with the retriever complex. Interacts with SNX31; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104118.1">
        <property type="nucleotide sequence ID" value="XM_022248426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEN5"/>
    <dbReference type="GeneID" id="110986512"/>
    <dbReference type="KEGG" id="aplc:110986512"/>
    <dbReference type="CTD" id="10311"/>
    <dbReference type="OMA" id="CVTMPIT"/>
    <dbReference type="OrthoDB" id="10263384at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000008">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000009">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022104118.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="32998" checksum="0502B46DD7B27FA7" modified="2022-01-19" version="1">MAFLDIRLKKVNKIYYEGDVLAGLVVVQSKSDVQHQGITLVVDGSVNLQLSSKNVGLFEAFYNSIKPIQLLNYVVSVAKPGKIPAGKTEIPFELPLKPKANKTLYETYHGVFVNIQYTIKGELKRPLLAKDLTKSIEFIVEYKDPKEKAQPKPVPFAITPESLQNIKDKGGLPRFSIKGKLDSAICCIKNPLTGTVVIEYCDAPIKSVEIQLVRVETCGCAEGYARDATEIQNIQIGEGDVCRGITIPMYMVFPRLFTCPTLATSNFKVEFEINLVIVLQDDHLITENFPVKLTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGI1</accession>
    <name>A0A8B7ZGI1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Synaptogenesis protein syg-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110986503</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022104107.1">
        <property type="nucleotide sequence ID" value="XM_022248415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGI1"/>
    <dbReference type="GeneID" id="110986503"/>
    <dbReference type="KEGG" id="aplc:110986503"/>
    <dbReference type="OMA" id="DRNIHIT"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1151"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="119"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="229"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="338"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="462"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="560"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="669"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="757"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="872"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022104107.1"/>
        </source>
    </evidence>
    <sequence length="1226" mass="131394" checksum="84E0AFAB7087C87C" modified="2022-01-19" version="1">MKVRRSILPTIIVLSDVTGNYPITGGIAYLVEGVDREFRCMVPEIDPGASFIWTVGSQVIGPDYNTNVTDANELFNSTSVITISATGYNHGELLKCKAWNVLNQPSTSVSVLLDVKVPPKVSSMTMYDSSGARIHTITKVKRITPQTFTCEVQGTRPAATIEWFLDGESQRTASAPSGGGDGLVNTTDTWSFTLGRVNHSQQVKCVASTAESRRPFPFVAVTLDVLVPPETILLFDSTTNDTSSSEVSYVVAGVGHQFTCEVPHINPGVSFLWTLGGQEVTPDRNIHITGEDGLTTSTSITTVTTTESNHGDTLQCRASNEDGNPGIAVTVTIDVKVPPVASRMSFFDSAGIRLQSTVEIDEGTVQNLTCMVEGTRPAATIYWFVGDDPHGCVSPKSTAGDDLVNTSATFTIIPSRVHHGQELKCVANTPDSQQPFPSVAITLDINAPPTGLTMLDSAGSYPSSGGVAYLVEGQPHQFTCSALDIDADASFTWRLGGQEIAGNSSSAAESSSGSWSNRTSSVTMLPTESHHGQIIRCEVSSENSPVDISTSVMLHVKVLPKVSSMVLSDAGGVRLYGDVEVNEGTPTTFWCEVRGTRPAPVIEWFLNDVLQRTKSPSSGGNRLVNSTDSWTLTPSRFNHRQELKCLASTADSKQPLPFVTITLDVNGSPDLPIIIGSPSMIENISTFLECQASMGFPSDWSLHWYSGDEPLPSNQTASAPQDDRFMFTSFLRFTPTRDNNGDTIRCVAHKESWTNTPETFLGPLDVQFCTKMVHITGCPQRVMSGRTASLSCAAETANPSTNLTWLREDVEQMSHALPVLTDGDYGGQVTTLDFITGVLTKKDNGALLKCCATSSICSEVCGDCSLNVQYRPYFSEPIATPLRPVDEGDNVILSCSAEANPMPSGFITWERVGFPDSLSSVHAHGTSILTLRNISKDQAGSYRCRGNNGVPPVVYSSQIDVAVHYEVSFANKKPDNLVKANLGEDALLVCVVNGNPLPIVIWANPLGALITNQTEPGRIFQVDTLVGGDDVVGYTVKSILHFHGVTGEGDYGFYSCSSGNGMGMVHTLRIQLIKGIPETTTSPSDHSGEIGSTSIPQGDIQVATFTTRAHQTSTSTLIARPATVLPAVDGSTSASPAVPYKANGVLSKDNLGLVAAVVVLVVFLLIVSIVLAVVVYRKYRTANTDLSVRKPMLKKYKPNKGKLDEDSVTAVELNDLDPEEVVTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGL3</accession>
    <name>A0A8B7ZGL3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho GTPase-activating protein 17-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110985573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102381.1">
        <property type="nucleotide sequence ID" value="XM_022246689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGL3"/>
    <dbReference type="GeneID" id="110985573"/>
    <dbReference type="KEGG" id="aplc:110985573"/>
    <dbReference type="OMA" id="WDYFFEG"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07595">
        <property type="entry name" value="BAR_RhoGAP_Rich-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000001">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF14">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 92B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="15"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="251"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="548"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022102381.1"/>
        </source>
    </evidence>
    <sequence length="697" mass="76483" checksum="F2122EBFE74A60F4" modified="2022-01-19" version="1">MMGKQYNRMKQLAKQNILRAEKTEVLNDDLQQCEKKVDIIKDACQKTVKKLSACLQGSGQDVEKRTRKLPHTVLGQSMLDSGQALGEDSVFGLTLGKTAEIWTSIGQDLTSHERGLEDLVITPFSGLLDNEIPSIMNLKKRLNRLTLDLDSAKGRYQTASSKGIDKDNVTKVEAIKEEMEQCQFKVDACKDTLATEMMSLVAKDSMMARCLVDMVESQAQYYRTVLLRLEKLIPELNASLQEAPSQGVFGHALEDHLRLQGRDIASPLEMCICWIMELGMDEEGIFRIAGSASKMKMIRAALDANVELDMELGLEHAAAGVLKQYLRELPEPLLTFPLYQEFIQTMTIKDKDQKLQALWAVINKLPKANYNNFRYLIKFLSKVAKRSDHNKMNASNLSLVIGPNCLWSEEDGGLSMTSTGVASTIIENFITHADWFFPEDIHFSPSSSKNNSFSETTQSSVDMTDHPILPAVTTSNAVPDSNLPPSPGVTITAAHPSPSQPGSVPASSSPQIDTTSPMSHHLTEKLKSSSLPRRSLKKNPAPPIPGVSPTQSPNSSLPRDTPVPSSSTLSVNNVNGNPPSHPTEKVTPERPDRPSKADKPAKLEKPPKADKPPVLEKPGRPPVPAKKNSQGRESRVPISPPPLVVADNVPPSPTLRPKSTSLSRPTISPPPPPPSQKSRKPAESIDSEYTPEEATQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZI43</accession>
    <name>A0A8B7ZI43_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110987156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105323.1">
        <property type="nucleotide sequence ID" value="XM_022249631.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105324.1">
        <property type="nucleotide sequence ID" value="XM_022249632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZI43"/>
    <dbReference type="GeneID" id="110987156"/>
    <dbReference type="KEGG" id="aplc:110987156"/>
    <dbReference type="OMA" id="TIRLRIC"/>
    <dbReference type="OrthoDB" id="5973910at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF47">
        <property type="entry name" value="NETRIN RECEPTOR UNC-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZU5" evidence="3">
        <location>
            <begin position="504"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="927"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022105323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105324.1"/>
        </source>
    </evidence>
    <sequence length="1019" mass="113586" checksum="9F533FD15FF6F4DB" modified="2022-01-19" version="1">MSSRPQHQLLEMEGRERLATVSGGVPFHREDRYIGKSLMHERSDSGFNSAASLAIPDEPGSEELRWGSSHLYRGGMTQQKHSARGVDGTVQRRYTVGAESGSQELLRTRRYPKGQQVTNVRTERHTRDRLSVVPDRLSRHENNDINFGHDRMHGQGAVSGFKYSSSLADKPGRDCPRGGSSYFLRDLQDTCSGSAFISNPDLGHGADDDGHRCTVWREAETRQPLTGRAIATISSSEVCNRPSSTIWMPDRKPRLHEEESRQRSCTSTPNLLIPDSIRLETEAEVAKHGQEGSLFLTKSAWGISSYTHGGYWTGSNYITNDKALRINSMGTSLPSATSSRGAISLQDWEEHGRVHNDISQQNFSSAVPANPVRVEGSNGGTLAVQGGPSSTPLDVIFIRRILSVASHCIPSPVSMRSNRDFDMQYSAEITDDAYQPPHVEEKRNPPSPELEPCSAHIEVPSDSRDLNQYANFEKKAYLEAFDMMRKCAMNLCIDIVGRVFQISNFAGAMLDRRGGYLSIDDLDVHLYVPFGAVPDGPPQLVYIFVEGNMIKDKDQLTPCIHCGPSALRFRKDVFLTFPHCAQDATNHLFTLTKSMSGRDIWKIRDGVDGLVLVKSHSITVTMDHFCGYVACALVSAKSMLACVFINEDITAGKAAIRLRIINNTKSDLREVELSEKKHDFYLADMEEQIWVERDGGDVIATLTSESECWEITKPACGTHTFKNWFLWRPSTSDRVSAYPSKLFFASRNSSVKTPFRACMTVKGHVEVEFLVKSPTKVRVHDLASTKKLVQVMMDKLPIHRDDSITFEHFLPEDIYQDLCDVLDLEMPIPVDWRRLPENLPGLSDQGCGLIRRIESRARLERRSPCGLVLDAFFAESMTTGRGKAESLRDLRRALHELNRRDVQFAIKAIDVQLMRCGAYVVAASPSPNHDINNNAENDSSVLMGRSTGEGQGGRETTGQLGTRMSDSLQRSPVYARQLGEDTATVSKPCFTQKDSAYSSLATAYSDEQLHLSEVRPQSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIV1</accession>
    <name>A0A8B7ZIV1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Speckle-type POZ protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110987282</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105567.1">
        <property type="nucleotide sequence ID" value="XM_022249875.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105568.1">
        <property type="nucleotide sequence ID" value="XM_022249876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIV1"/>
    <dbReference type="GeneID" id="110987282"/>
    <dbReference type="KEGG" id="aplc:110987282"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18345">
        <property type="entry name" value="BTB_POZ_roadkill-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000028">
        <property type="entry name" value="Speckle-type POZ protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000008">
        <property type="entry name" value="Speckle-type POZ protein-like a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="18"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="6">
        <location>
            <begin position="187"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022105567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022105568.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41000" checksum="89E2F61F37020830" modified="2022-01-19" version="1">MSCPVAENWCYTQVKVVKFSYMWTINNFSFCREEMGEVLKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCNKAEVRAKFKFSILNAKREETKAMESQRAYRFVQGKDWGFKKFIRRDFLMDEANGLLPDDKLTLFCEVSVVAETVNISGQSSQAQLKVPECRLADDLSALWERTSFSDVTLCVTGKEFQVHKAILAARSPVFNAMFEHEMEEKKLGRVDITDVEAEVMNEILRFIYTGKAPNLEKMADELLAAADKYALERLKVMCEDALCSNLVIDNVAEVLVLADLHSADQLKAVAIDFINSSHAPEVMETAGWKTMVHSHPNLVADAFRALATSQSPPFMGPPRKRIKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJC4</accession>
    <name>A0A8B7ZJC4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Uncharacterized protein LOC110987314 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9" type="primary">LOC110987314</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105632.1">
        <property type="nucleotide sequence ID" value="XM_022249940.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105633.1">
        <property type="nucleotide sequence ID" value="XM_022249941.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105634.1">
        <property type="nucleotide sequence ID" value="XM_022249942.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105635.1">
        <property type="nucleotide sequence ID" value="XM_022249943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJC4"/>
    <dbReference type="GeneID" id="110987314"/>
    <dbReference type="KEGG" id="aplc:110987314"/>
    <dbReference type="OMA" id="DSHQSTE"/>
    <dbReference type="OrthoDB" id="2538319at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22686">
        <property type="entry name" value="FHA_AGGF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16164">
        <property type="entry name" value="OCRE_VG5Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035624">
        <property type="entry name" value="AGGF1_OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="626"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="812"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="870"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="964"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="913"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022105634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022105635.1"/>
        </source>
    </evidence>
    <sequence length="1269" mass="139038" checksum="0FFAE7710F323AC1" modified="2022-01-19" version="1">METTMTDVEDQIGVMHSPTADLDVPRLKVKGLSEELAETKAKLATTQAELVRTEALRTEAEECSVKLRKKVEKLSQELEDLHKAAKTSISDVSCQTDPVASDVSSTEGTVAGSTGPSDWVTEVGTSGQSASQSVADSVRAAAEAATTRTGFVLDQTSGMYYDCNSGFYYDQVNKLYYDPSNGIYYYFDEGTGSYQFHSQVELPTAAQYGQGRRGKGRGNAWGKRKDRRLGEESREIDVRRRESLEDMDCQIIEIGQDTRHGYKRRRRDATENQMRGSSERVDNDAPRRAHRERRHRRERHSHGRGDIGDGEATSEQHTHELKKRMQSLERRRKQRRKSQSRRRRKKSRDRGRRDEEYDGRYPSGLQDQESVEGLSDGEIRNDEGLDMDGLEGGSSQSRKNHRTTDENRNQFVENEGAGNSPDRGLGETDAAGSGKQKDETSPETVGGSSENSTAKDDSPLGEEGKADEGEAQGQGSAEEAAEVRSHCQVIVPNPEAEPRRGGAKEQPNGSEGGFGGEIHKGYSDGEIIEDVMIVEDGEEPIVLSSDEMEEGELSDSLSEVSSSEGSSLDSSSATSEDGLEEISVDSDSSSGLEVLKVDYPPCIRMIVTKSDTLKPGSLFIITCAGGTIGREGSNHALLIQSVKVSKRHAHIIYDAQERQYTIVDLGSQNGTLLNGKAISEQRVVSEPHPLSHRDYITIGGTTLRLHIHPGDETCEECEPGQVQALIAQQQLNEMSAGTTSGSRPEKEQQRRKELRHLKKKYNLAKDDYSNVDPSLINPAYADRAGERRRAVGSDNPYQPDDQPASVDRAIESSNVGHKMLSKMGWTEGQSLGKGDRGIKEPIQAVVHSRNAGLGSRVVQSMDQVQYARRRNDNWDKARGRFNLTDPQQSAAANRGKKAPTWVQGGTEKLDASPQHSTADDPSSGNAFGMVQLPLAERGKADGRRRTSQGIVDIWDNSMDAGRTSWLGSSKGMEETIHSRDQQHSRDSQEKQRDDSTEYERLFLGDRAQSGNLEGATEALGAPFTADSSFKNVQLTEGSHDESKRTRQPPRGVEDRLLHSSTSTVDTDAGRVSEQIIPADSSCVGLEESNTAESSVKKTVSDGESSLTASVDSTDETSTNTPQLPTPREMRVDREQNTGGPENIDKAVQSGSLPSRISDENLEASAKKTDVKNGEQPKSVVQPSQEGTEKAKKIQLKWSKGGKEKLATSLVAFEESESDGENGDDLAGNSKSVEQEQVQQPQGEEHRASRSRRGSNKPSRWSSSRNSSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKU0</accession>
    <name>A0A8B7ZKU0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyroglutamyl-peptidase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987248</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105505.1">
        <property type="nucleotide sequence ID" value="XM_022249813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKU0"/>
    <dbReference type="GeneID" id="110987248"/>
    <dbReference type="KEGG" id="aplc:110987248"/>
    <dbReference type="CTD" id="54858"/>
    <dbReference type="OMA" id="KLAYNHK"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.20:FF:000008">
        <property type="entry name" value="Pyroglutamyl-peptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105505.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22779" checksum="2B37C203AF981286" modified="2022-01-19" version="1">MPKKSTVVVTGFGPFWEHKVNASWSAVQELDRLGLEDEDVELITFEIAVEYETAKKLVPQLWKEYDPCLMVHVGVSGIAKELTLEQQAHNTGYDKPDVSFLVPKSKCCIRDGPDCILSQINMSIVSDEVNSNSCPTKAVVSYNAGKYLCDFVYYISLYQNCAQTAFIHVPPLGKPYSARQLGEGLRAAIRSMLKQVRQTKGEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLM9</accession>
    <name>A0A8B7ZLM9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-aminocyclopropane-1-carboxylate synthase-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106369.1">
        <property type="nucleotide sequence ID" value="XM_022250677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLM9"/>
    <dbReference type="GeneID" id="110987700"/>
    <dbReference type="KEGG" id="aplc:110987700"/>
    <dbReference type="OMA" id="YPAFYRD"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="111"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106369.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="59948" checksum="B60B669B4376F540" modified="2022-01-19" version="1">MLADSSPDHAACWRWPRVVLERTTDREERLVDFVKHLMSDMSVLSKRGERLLSTENLLAKGFGRCASNLYDGETNPNGCINLGTAENRLVFDLLKERMNGYNVQWEDYMYTYQNSQGIPELRKAVAGFLSDQAKSPKPLDPENIIIMNGGGICMEALSFSICDPGDGVMVASPYYGGIENDIVLRPEAKIIPVHFYSKSEPGLTEPFEITISKFESVYKEETEKGMKIRAVVFMNPNNPLGDVYPKQMVLDMLHFCHRHSLHLIMNEVYLNSIFKEEVAFQSFLSLKPEEVPDPEKVLQDMSMSGMRFGVIHTLNTSIISCINTFAYFQLVSVYIQKVMARLLSDKDWLNNVFFPTNNKRLREAHKVTTDTLDEIGIPYLNRPSGLYVYANFKKFMPSLTAESEMALFYRFIKDGIYIAPSLAFYSDERGWFRIIFTRPLDEIKLAMERLAKVCHLLQEENKQSLSIAPAAERGGAGDSSQSKSLEALVSQLQSEMAKSDWLETNTADKWKAENPKLFQEYMANFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLR9</accession>
    <name>A0A8B7ZLR9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 4C1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110987520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106002.1">
        <property type="nucleotide sequence ID" value="XM_022250310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLR9"/>
    <dbReference type="GeneID" id="110987520"/>
    <dbReference type="KEGG" id="aplc:110987520"/>
    <dbReference type="OMA" id="PAKMNRD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF189">
        <property type="entry name" value="CYTOCHROME P450 4C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022106002.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="59071" checksum="7A2DC0E126DF6A75" modified="2022-01-19" version="1">MSFFLPVFVTAAAVFTAYYGYVLFQFLYKPWKQLQYFSKKIPGPVALPFIGNAHQLEAEPAKFYQQILGFCQDFPKFFRIMLGPIAMIVITNAKDAEVLFGSTKHIAKGFVYDFLQPWLGTGLLTSKGSKWFLRRKMLTPTFHFSVLHSFLTVFNEKTDILGVRLKMMTDGQVFDIFPFITQCSLDIICETAMGKNIHAQEDRKNEYVQAVIKMSELALERMKYPWLWPSMLYSILPHGKQHAECLKILHDTTDKVIKGRYQEFVKMYPRGLRNPSADEPQKKRLAFLDLLLQMKQENKSFTFDDIREEVDTFMFEGHDTTAAGVSWCLYLLGRHPEIQHRVQKELDEVFGSTQGPVTSDQLQRLHYLTCVIKETLRIFPSVPFIARVLDEDCVLGGHKIPSGTNVCVLINALHRDPDVFPNPEEFDPDRFLYQNCISRHPYAYVPFSAGARNCIGQRFAMMEEKVIVSSVLRHFNIESIQARHEVLPISELILRPSKGIQVKLTPRVFNGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM73</accession>
    <name>A0A8B7ZM73_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987608</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106167.1">
        <property type="nucleotide sequence ID" value="XM_022250475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM73"/>
    <dbReference type="GeneID" id="110987608"/>
    <dbReference type="KEGG" id="aplc:110987608"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106167.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="19780" checksum="BAAA8E1C538AFA94" modified="2022-01-19" version="1">MPEPARSPSSDNSTSVELCDLRNPGNVSITNCTLRRILPINLTWTKEWTRPQSLKITSSDRDPTGMTTAGIQEHMRTEATSADMRVQVSMTTASDKGHNTTTKTIITKGGGGVTHKGVTMVETSQVVSTTATLTGEPGMGTDIHPTRGGDVTMTESEGTHGDLTRPDTPFHMPLQKTNGHNVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNL4</accession>
    <name>A0A8B7ZNL4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Optic atrophy 3 protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110988087</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107019.1">
        <property type="nucleotide sequence ID" value="XM_022251327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNL4"/>
    <dbReference type="GeneID" id="110988087"/>
    <dbReference type="KEGG" id="aplc:110988087"/>
    <dbReference type="CTD" id="80207"/>
    <dbReference type="OMA" id="WAEFEGT"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022107019.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17881" checksum="274EDFDA8773A022" modified="2022-01-19" version="1">MAGFQQAAFPLIKLASLAVKQISKPLAKRIQMMAKTRPFMRKYICIPPAQLHHWMEVNLRMKILGLGKASSVQPLTEEAAVELGADIIGETFLFVVAVGTIAFEYYRLQRKDQKHEGEQTAAISTLQQRVEELGITVEEQDARIRELHRQVVGLSPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPS0</accession>
    <name>A0A8B7ZPS0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronic acid decarboxylase 1</fullName>
            <ecNumber evidence="5">4.1.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-glucuronate decarboxylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110988101</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:23917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022107042.1">
        <property type="nucleotide sequence ID" value="XM_022251350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPS0"/>
    <dbReference type="GeneID" id="110988101"/>
    <dbReference type="KEGG" id="aplc:110988101"/>
    <dbReference type="CTD" id="80146"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000065">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="18">
        <location>
            <begin position="92"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022107042.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46361" checksum="99B36B5F129B9BEB" modified="2022-01-19" version="1">MTFSWSSVAMCMKRFRLALIIGVVFAVLFGLLCGTRGEEDSRWVKDLGEGVQVQLQKLIQPLQERLTELEKQTMKKYPEVRYLPESERKRILITGGAGFVGSHLTDRLMMEGHEVTVVDNFFTGRKRNIEQWVGHPNFELINHDVVEPLLIEVDQIYHLACPASPPHYMYNPIKTIKTSSLGTLNMLGLAKRTRARILQASTSEVYGDPQEHPQTEEYWGHVNPIGPRACYDEGKRVAETMCYAYAKQDKVDVRVARIFNTFGPRMHMNDGRVVSNFILQALQDQPITVYGHGKQSRSFQYVSDLVDGLIKLMNSNESSPVNLGNPDEHTIMEFAQIIRSKIGGNSVIQNVAAAEDDPQRRKPDISKAKKILGWEPVVPLDRGLQLTIDYFRNELEHAAKMKVPGKPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPY1</accession>
    <name>A0A8B7ZPY1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U6 snRNA-associated Sm-like protein LSm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110988050</name>
        <name evidence="10" type="synonym">LSM4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106960.1">
        <property type="nucleotide sequence ID" value="XM_022251268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPY1"/>
    <dbReference type="GeneID" id="110988050"/>
    <dbReference type="KEGG" id="aplc:110988050"/>
    <dbReference type="CTD" id="25804"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01723">
        <property type="entry name" value="LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000005">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034101">
        <property type="entry name" value="Lsm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106960.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16236" checksum="660FAAB67B70622B" modified="2022-01-19" version="1">MLPLSLLRTAQNHPMLVELKNGETYNGHLVACDNWMNINLREVICTSRDGDRFWRMPECYIRGSTIKYLRIPDEVIDMVKEEVVAKGRGRGGGQQRGRGRGGPGRGVQLKVGAPFSCLGSCGCCSTESQSVLYGSTLFVYHKNLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQ57</accession>
    <name>A0A8B7ZQ57_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-acetylgalactosamine-6-sulfatase</fullName>
            <ecNumber evidence="6">3.1.6.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Chondroitinsulfatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Galactose-6-sulfate sulfatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylgalactosamine-6-sulfate sulfatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110988485</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.</text>
            <dbReference type="EC" id="3.1.6.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.4" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022107718.1">
        <property type="nucleotide sequence ID" value="XM_022252026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQ57"/>
    <dbReference type="GeneID" id="110988485"/>
    <dbReference type="CTD" id="2588"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043890">
        <property type="term" value="F:N-acetylgalactosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000048">
        <property type="entry name" value="Galactosamine (N-acetyl)-6-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000021">
        <property type="entry name" value="Galactosamine (N-acetyl)-6-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF47">
        <property type="entry name" value="N-ACETYLGALACTOSAMINE-6-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="19">
        <location>
            <begin position="37"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022107718.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="59222" checksum="FB9907A98348075F" modified="2022-01-19" version="1">MVYIIVHTCTWLIMARYLIFSVVLIFFSGVRPISGKPNIIIMMMDDMGWGDLGIFGHPAKETPNLDQMAAEGVLMTDFYSANPLCSPARAALLTGRLPIRNGFYTTNQHARNAYAPQFVVGGIQDYEILLPELLKKAGYKSKIIGKWHLGHQPQYLPLQHGFDEFFGSPHCHFGPYNDKGTPNIPVYRDGEMAGRYYEDFVITKTGESNLTQLYIQEALDFITVETQLASPFFLYWVPDSAHQPHYASKHYLGTSQRGLYGDVVRELDDGVGQILSHLQHLGIERNSFVFFTSDNGAPLNAKADGGSNGPFLCGKETTFEGGMREPAIAWWPGTIKPGQVSHQLGSIMDLFTTALKIAGLSPPSDRIVDGTDLLPNLVNGTIDSAKPIFYYRGNEMMAIRIGLYKAHYWTWTNSLQEFEKGVNFCRGENVTGVMTHQQTNHTDAPLLFHLGRDPGEKYPIEQTTQEYKEVMPMIMRVVGNHKEKLVPGQPQLNMCDWAVQNWAPPGCEKLGECLPIPKSHPYKCSWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQU5</accession>
    <name>A0A8B7ZQU5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110987405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="RefSeq" id="XP_022105811.1">
        <property type="nucleotide sequence ID" value="XM_022250119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQU5"/>
    <dbReference type="GeneID" id="110987405"/>
    <dbReference type="KEGG" id="aplc:110987405"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022105811.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22160" checksum="26C090D2164394AA" modified="2022-01-19" version="1">MAKSKRAYYSCVIKEGYNYTRISTGSHLQSHTAKFCHLAIHRYLYRLTHRSVNDAAGWVYSPGGELEWSYGGGSGVELHIEGDFFIDGGGLPGKQYKVAQLHYHWGNPNALGSEHAINGRKYDAEMHLVTYDTNYTSLKEAKTHTDGVAVFAAMVQVGLKPNFDGSSFDEFISGIQSLGSKDGCILPPLWQRSKRLHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQY3</accession>
    <name>A0A8B7ZQY3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain family 4 member E-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107983.1">
        <property type="nucleotide sequence ID" value="XM_022252291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQY3"/>
    <dbReference type="GeneID" id="110988599"/>
    <dbReference type="KEGG" id="aplc:110988599"/>
    <dbReference type="OMA" id="PVICERP"/>
    <dbReference type="OrthoDB" id="8950604at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107983.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="10891" checksum="DFAD744FBE3CDA83" modified="2022-01-19" version="1">MGSVLVMPQSQEETEFLLNLIYYFWINCNDIEVEGSWECKDGTTDVKYRNWRAGEPGFSGIWEDCAATDKKGWNDVPCSDLSPVICERPTPRLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTR2</accession>
    <name>A0A8B7ZTR2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">von Willebrand factor A domain-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110989040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108814.1">
        <property type="nucleotide sequence ID" value="XM_022253122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTR2"/>
    <dbReference type="GeneID" id="110989040"/>
    <dbReference type="KEGG" id="aplc:110989040"/>
    <dbReference type="OMA" id="NTERTMR"/>
    <dbReference type="OrthoDB" id="10043511at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056475">
        <property type="entry name" value="GBD_Hemicentin/VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056861">
        <property type="entry name" value="HMCN1-like_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056862">
        <property type="entry name" value="VWA7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23560">
        <property type="entry name" value="GBD_Hemicentin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25107">
        <property type="entry name" value="VWA7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25106">
        <property type="entry name" value="VWA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034488202" evidence="6">
        <location>
            <begin position="26"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="domain" description="VWA7 N-terminal" evidence="9">
        <location>
            <begin position="78"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Hemicentin-1-like von Willebrand factor A" evidence="8">
        <location>
            <begin position="346"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Hemicentin/VWA7 galactose-binding" evidence="7">
        <location>
            <begin position="532"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022108814.1"/>
        </source>
    </evidence>
    <sequence length="1078" mass="116028" checksum="5793AFC319167047" modified="2022-01-19" version="1">MELTVKLTRSLWVLLVACLVRQSVAFLPNNAGNTLPITDYTLTEITVQGIVRAVAKYFEDTNPDRYNPGDLTGLSPLTPSRLFRQHYGDCVYATKFERAIRAIVDANVEISDKYAHKAIWHFNGNQVNKGNSKMVSIRRALLNLLQLGNEDAPNYDVARQFSGQFLHMAQSFYSNTNWVELNRWLNSLIGADQNEVITSSELGIIAPLSWRQSPGSVDMCQNCPGSTSLPGLQDCSDNLRPYVYYLTSGYRSGQNVNKPAASPGNIWGKCSHGGLHDASWTEVAIGGINKESSDEQRSPHFDLHEQAALTALQATEDFFYRSGTGLYGLIGERKFRRLLNLDVGTSLTFVIDVSGSMSDDIKAVKEETIRIVELHKETCLAASKYVVAPFNDPGYGPALVSTDAQKCIEFLGNLTAKGGGDCPELANSGLELGVQNSIIGANVYMFTDATDKDKEKVPDVLALIEEKKVHVKFLLTGTCSSSRRKRATDWSTLSPSYQIIAEASGGEIYRTDKDGIRDLARIMEGDIRASQVSIIKRSSLNLDALSLDIPVDSTVQEVLVSVVGSLSSDSVIIRHPNGTEGTPDELGADIFTNSAEQIVFSINVTEPDTKGNWVVKLQNLNLATEYYIKVSANSVLDFTFDILETDETGTAYPVDGKPVAGAEVLLTVQVSAPETVSSVSEIKLYNAMGNETLVTASATPVEGRTEGLFMASLTLPNEPFFVSIVGEDTQGMEFLRTQPSEIKVVEFKLEEISGSNTVDNLVPGGNGSFSFRVTNSGPDDTLTMTVSVLETAVNSSRSALRAVSGPVVTAAVEPASMVLATGEKGEGVLTVTAAEDVPAGTSVKVTLSIASSLSSSLNFLSIDATVFAVENDTDENPDESDSTPPTCEILSSGGGCTAQQMSSDCNKHEWWVRARAVDNNIVTEVVLDPEVEVGGTGKQSLVYESFFPTNVTFKYSASCCCPIMKFTVRDGASNEASCGKDHYTALSGQVEKPDCNGPVLSDTGLSIGAIVGIAVGSVAAVVIVGAVVFFVAKHTFGASGKASRSVTPLCYPSTDNEPLSYKNPMPAIHESQNYYNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTV8</accession>
    <name>A0A8B7ZTV8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110988004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106921.1">
        <property type="nucleotide sequence ID" value="XM_022251229.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988004"/>
    <dbReference type="KEGG" id="aplc:110988004"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="7">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022106921.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16999" checksum="A363C204C767CDEC" modified="2022-01-19" version="1">MHLVVKELKKPRNEMKFQVEVANLDVKKKNLTKTKPTSTLLRNLKNRSGRDQTGQISIRHRGGRAKRKYRLIRILIRETRCLRKIDKNCRATIGVVGNEDYRLVRLGKAGRKRXSGIRPTVRGAAMNRHDHPHGGGEGKAPIGLSGPRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU23</accession>
    <name>A0A8B7ZU23_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110988922</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108582.1">
        <property type="nucleotide sequence ID" value="XM_022252890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZU23"/>
    <dbReference type="GeneID" id="110988922"/>
    <dbReference type="KEGG" id="aplc:110988922"/>
    <dbReference type="OMA" id="RLTRIYY"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="118"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108582.1"/>
        </source>
    </evidence>
    <sequence length="603" mass="68762" checksum="4902FB5416A2CDF7" modified="2022-01-19" version="1">MSDHYTMVPFRCSCTLTYRISPVGTEANMALSRRKLGTAISLVLFLLAMMSVAFQKRYGQGWLQLVAISDVFDGTPRTLRGKLYKHQGTMSIGITQESSEHRQRRIIIIGSGPTALGAARRLAELRDKFNFRITILEEAAQPGGLASSERDDKGFLWDMGGHVVFSHYDYFDKTLDRAVAHWNQRVRAAFAFMMGSDGQRRFIPYPVQNNIEVMDKIDQNKSLAGLKEITRNPSQGKPRNFDEWLLQHFGVGLCDVFMRKYNKKVWTVNTTEMNSVWVGERVAVPDINKIQAKIKAFDQGTPAEDSGWGPNRFFRFPRFNGTGNIWRGVARLVPREWFEFRRQVTSVNFDTKTVSVESAGNEHRLLHYDTLISTAPLDEFVHLLQGDDPSLARMNVLASQLIYSHTHVIGIGLVGQPPKMLSDKSWMYFPDADSPFYRITVFSAYSDDHVPKAGEYWSLMCEAAEPKDTPDRSHWTQANVVDSTVKALITYGFISADMVVSKYYRRLDHGYPVPSIGREGILEVVQPWLEAKHIYSRGRFGGWRYEVANQDHSFMQGVELVDKLLRGIPEETYPNPNLVNSRKNTGRFLDNDDSKNKFILLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV91</accession>
    <name>A0A8B7ZV91_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C1orf131 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109473.1">
        <property type="nucleotide sequence ID" value="XM_022253781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV91"/>
    <dbReference type="GeneID" id="110989408"/>
    <dbReference type="KEGG" id="aplc:110989408"/>
    <dbReference type="OMA" id="QRVFEQE"/>
    <dbReference type="OrthoDB" id="10067479at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052852">
        <property type="entry name" value="SSU_Processome_Comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28366">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28366:SF1">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022109473.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="36519" checksum="D5A72030C16BCC5E" modified="2022-01-19" version="1">MSNIDGDNMDDILQRQLLNRLNEYGDNLLDEEDSDQKKSKIEKVKSKTKEQSVNWHNDHTNAAPNPSFSSSNKTRKKKKGKKKPSGTRSEGDEESARKKQGREVMDFEEELRQFKEEELQRQRLRKEAEQRQEGGKTKTPAPEVIVFEDPTRRKKKKVVDQDETNPSQGEFNLKRARLEVRQFGLTGFSFEDREKCEADRAIHLGAWAPKREYVNYKEYMAMQKKKKEEERHQREIDRKMGLKVSKKPTTEKTRVRNQGFWRDPSQDKKFFLDGQVGRYKQGVQVVGKDDIARVKTTSKKGNRPGSTRKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVC9</accession>
    <name>A0A8B7ZVC9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110989354</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109374.1">
        <property type="nucleotide sequence ID" value="XM_022253682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVC9"/>
    <dbReference type="GeneID" id="110989354"/>
    <dbReference type="KEGG" id="aplc:110989354"/>
    <dbReference type="OMA" id="MNAPHET"/>
    <dbReference type="OrthoDB" id="10014857at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="34"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022109374.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13466" checksum="4C3D241F46CFB2B4" modified="2022-01-19" version="1">MPRYGDPTTYYGICSDVPVTAPKGPLCDEELLRIASSLSNDWRMVAQSLGLPDNRIGSIERGFPPKERLFAVLRDWRGKSLKMNAPHETAVDLANAMFELGRDDIGHHLVKKYQDAFECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVT3</accession>
    <name>A0A8B7ZVT3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Max-binding protein MNT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myc antagonist MNT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110989079</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108885.1">
        <property type="nucleotide sequence ID" value="XM_022253193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVT3"/>
    <dbReference type="GeneID" id="110989079"/>
    <dbReference type="KEGG" id="aplc:110989079"/>
    <dbReference type="OMA" id="TVDIMPK"/>
    <dbReference type="OrthoDB" id="5981879at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11402">
        <property type="entry name" value="bHLHzip_Mnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000034">
        <property type="entry name" value="MAX network transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF99">
        <property type="entry name" value="MAX-BINDING PROTEIN MNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="12">
        <location>
            <begin position="92"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="176"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="517"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="935"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022108885.1"/>
        </source>
    </evidence>
    <sequence length="959" mass="101737" checksum="9FDFC48BDD7255A0" modified="2022-01-19" version="1">MSIETLLEAAKFVEWSDQIGHSARGQNDPEVLGHSHNGQSMAFSGPSYVAVSSSPSSSPGSNKSSPVTSSRQQNVSSSNTDTLDEGDDKRSGTREVHNKLEKNRRAQLKECFDNLRDQIPNLDNKKLKPSNLSILQGALRYLQALKRKERELEYETERLARQKILYQEKLAKLSGCSLPPWKKAEPEPKEEEAENEMQDDKEDDRESVSTSTSTASEAEEEERKSRAQSPESKSSPVVQGSEKSNPSAVRTGPLKDRVIKVTQSVKEQSGPFVISRQIVTRVPMSTSATASQQQQQVAAQMPHQLQGANHKKATSQLQTAQGPAGQTQSMVVGTNPQLTITKESVPQRPPETMTQRVAATQKVVIRPPSAAQLIKTQQTLTQKPSSATQSTILKQPTSGPMQPSSLPQVIRQFDSHSTAVSAVQEHLKNKAQSKIPQQQKNPVRTISTTTMTTESTASSKANIPVVSTAAVVTSSTGVSRQTVSQLLGKQSMVIRQPVRRTDNKLIVQRVLPHPFSPRPQTVDIMPKSPTALSSSDSVKSKTNQATPTSITVVTYKDLPPSITTSIMSGSVPTTSSNIATNVSKQSVLTCTVQQATPSADARNLISHSVMLSSVPHYPPTAGFAATMLRPNPSMLTAANATLLNQAMVAGPRNVTSQLTFPGSKDSSPGKLQSPASGAVSFFPTAVTQARVSTVSHLKVPSLSYTTPMTPVHSFLPPGLTLQPALTQVLFTQPPNAAYTLANSTPAQTLVNTTQSHQTVIRHPLAATAGAQLPQVVTTMATAIVSSTCNAQTSVAMTLPPVVTIGALSLNPLLGTNRALVTAPTYTTLGQYPHRFPFAGQVPLISPVAFASNPSNAALPVTSVGSPASNNGKASNGVIVHTVAVPAGMPVTSSWLDTSNVSNGIPVKDLMLTAPATSGSSVIMGTTQPAVTTVPISSQEGSVDDSKIGSEPSVVVTSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZW62</accession>
    <name>A0A8B7ZW62_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110989523</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109664.1">
        <property type="nucleotide sequence ID" value="XM_022253972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZW62"/>
    <dbReference type="GeneID" id="110989523"/>
    <dbReference type="KEGG" id="aplc:110989523"/>
    <dbReference type="CTD" id="29928"/>
    <dbReference type="OMA" id="VNPNMAD"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022109664.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="20976" checksum="DC4A9EB0E0444A41" modified="2022-01-19" version="1">MATYMGRSMNDSSQDEIQDSTELSSVNMVDMMDVLIGPNKKKHNEGLRQFGLPQAPKTREELTMERVMESCTFKTVMSCVLGFALGAAIGLFAASVDPVDPDQAAKQKARDVLKDMGRRSVFHAKNFALIGAMFAGTECIIESYRGQSDWKNSPIAGCVTGGLIGYRAGLKPGVAGCVGFAAFSAAIDHYFHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXB0</accession>
    <name>A0A8B7ZXB0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 26</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cofactor required for Sp1 transcriptional activation subunit 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Mediator complex subunit 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110989559</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 26 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109732.1">
        <property type="nucleotide sequence ID" value="XM_022254040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXB0"/>
    <dbReference type="GeneID" id="110989559"/>
    <dbReference type="KEGG" id="aplc:110989559"/>
    <dbReference type="OrthoDB" id="10057627at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042376">
        <property type="entry name" value="MED26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031416">
        <property type="entry name" value="Med26_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15201">
        <property type="entry name" value="CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15201:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15693">
        <property type="entry name" value="Med26_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="448"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022109732.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="60213" checksum="15B5EFAD1F84E23A" modified="2022-01-19" version="1">MYIYNYLAVGFNRVVPNSVEERGDGRFSNVINMVGVLEAIACLENIQITKEALEETRLGKIVNDIRKNTEDSALSVRCKKLVRVWSKQFVRGSPSAGKTASSSTQDATTNRQPTPPTQGTTSAQSSGGNRTPSLKTQTSTTPSSSSTVDKKKSENRKRRKLSTSPSTASPTGSATTSAKKLRPAASTPISNATKEQTNQETKNGMSAQREGSRSDLQSSKSAFSKVKPPEHKASSRTGSPALKVTGQSSPDLSKLNANTSKAHSKSPLLTKHTSSPVIGSKLSPAVVGSDKAGRSSPSVKAKQPRCSNSTDSNRLDVTDSTALTGERTQGTTHKDSAATNRLQSKSPNTHNTLQDSNSSSATVKLRSPAASVEERCATPTHTACCAPYISHDHMLPESQSSDQVLQETDSSRVSFSIFDDDYDEEDETLSEERYDRATVDFEKVPAVTSSLTQKADTDRPPSSNLVDDALPGADLEVDGQPMDAPEALPTQDAHVHLEEEPAPARPVTADDLTRVHSQQWDGVNGCYSDRNEWSDWTQCLSITTQDDNALHILPYICLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY02</accession>
    <name>A0A8B7ZY02_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="22">P2X purinoceptor 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110988845</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the P2X receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108441.1">
        <property type="nucleotide sequence ID" value="XM_022252749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY02"/>
    <dbReference type="GeneID" id="110988845"/>
    <dbReference type="KEGG" id="aplc:110988845"/>
    <dbReference type="CTD" id="5025"/>
    <dbReference type="OrthoDB" id="494673at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004931">
        <property type="term" value="F:extracellularly ATP-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001614">
        <property type="term" value="F:purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033198">
        <property type="term" value="P:response to ATP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.490.10:FF:000001">
        <property type="entry name" value="P2X purinoceptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.940:FF:000010">
        <property type="entry name" value="P2X receptor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.940">
        <property type="entry name" value="atp-gated p2x4 ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.490.10">
        <property type="entry name" value="atp-gated p2x4 ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027309">
        <property type="entry name" value="P2X_extracellular_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001429">
        <property type="entry name" value="P2X_purnocptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059116">
        <property type="entry name" value="P2X_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053792">
        <property type="entry name" value="P2X_RECEPTOR_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00863">
        <property type="entry name" value="P2X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125">
        <property type="entry name" value="P2X PURINOCEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125:SF31">
        <property type="entry name" value="P2X RECEPTOR E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00864">
        <property type="entry name" value="P2X_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005713">
        <property type="entry name" value="P2X_purinoceptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01307">
        <property type="entry name" value="P2XRECEPTOR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01212">
        <property type="entry name" value="P2X_RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="359"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="317"/>
            <end position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="133"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005713-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005713-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022108441.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47643" checksum="2EA0EAA2338E6AA7" modified="2022-01-19" version="1">MTSPEENVPGVGSLLISWALEYDTQKIVHIKNKTIGFLNRLIQLAIVAYVIGYAIIYKKAYQSTDTVISSVTTKLKGVSYTNISGLPDLNIKDTTPYDRIWDVSDYVVPPQQSNAFFVMTNMIITPNQQRGQCPEDPRVPNVGCTPAKESQDCVKGEPVINGNGVRTGKCVPYYYPNGTETYTCEIEAWCPVEYDVNPTQSEPVLKDAKRFTVLIKNTATYPKFHFSKRNILESSNKSYLSGCMYNNETDPFCPIFKLGDIVAATGEDFNKLAYSGGVIGISINWDCNLDYSWKDCTPLYTFSRIDNSEAKLAKGYNFRFSNYYQNETGIDTRTLFKAYGILFEVIVTGTAGKFDFVPLMLNIGTGLALLTMSTVACDIIVCYIMKGHEYYKKKKYLTVKPDAEVNVDYEPLDNASVCSKETNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZF4</accession>
    <name>A0A8B7ZZF4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein LOC110989123</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110989123</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108961.1">
        <property type="nucleotide sequence ID" value="XM_022253269.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989123"/>
    <dbReference type="KEGG" id="aplc:110989123"/>
    <dbReference type="OMA" id="WEFRCGR"/>
    <dbReference type="OrthoDB" id="10020456at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000027">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2661"/>
            <end position="2686"/>
        </location>
    </feature>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A092</accession>
    <name>A0A8B8A092_ACAPL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990471</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">LOC110990471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_022255486.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="aplc:110990471"/>
    <dbReference type="OMA" id="PAFWHAY"/>
    <dbReference type="OrthoDB" id="5982044at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="CIMIP3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35444">
        <property type="entry name" value="RIKEN CDNA 1700001C19 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35444:SF1">
        <property type="entry name" value="RIKEN CDNA 1700001C19 GENE"/>
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    <dbReference type="Pfam" id="PF22581">
        <property type="entry name" value="CIMIP3"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_022111178.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17198" checksum="0CF0E0C02D356E1A" modified="2022-01-19" version="1">MPNSGYQGLINQHFYGENKTDIFPLGGKYGQQNLPCPAFWHAYIRGNQPAVHRGTDTRNKYSRHLNLSDPLAGVGLPSSPASSMKSAPSSEIPYEAPIAPSNCLFVQGGIKSNSVAPFATLAKPTCGWFFSRSTDHKKRRTGIPPADLVKWRYYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3B7</accession>
    <name>A0A8B8A3B7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 9B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110991221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112184.1">
        <property type="nucleotide sequence ID" value="XM_022256492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3B7"/>
    <dbReference type="GeneID" id="110991221"/>
    <dbReference type="KEGG" id="aplc:110991221"/>
    <dbReference type="OMA" id="QDIEAYC"/>
    <dbReference type="OrthoDB" id="10059035at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008853">
        <property type="entry name" value="TMEM9/TMEM9B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13064">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 9 FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05434">
        <property type="entry name" value="Tmemb_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034973245" evidence="7">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022112184.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20049" checksum="EC91DD1909331235" modified="2022-01-19" version="1">MSFNTFTFVLLIGIVCFGVTKAQFEDCRCKCVCPGDPKTKHKVNVTVVSVPAYECFCEHITGRSELECLRCECRYEVRSTTVIKIVVIFVLVLIAILLVYLIALLIMDPGMLKRSESDRRRQTQEILHQDSSNGLHESSYLRRRLGRVGSAQKRWQHKVKQQRQDVFQDHTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A492</accession>
    <name>A0A8B8A492_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990980</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111735.1">
        <property type="nucleotide sequence ID" value="XM_022256043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A492"/>
    <dbReference type="GeneID" id="110990980"/>
    <dbReference type="KEGG" id="aplc:110990980"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="42"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111735.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="28852" checksum="E02F23AECA3EBE9D" modified="2022-01-19" version="1">MADLPPFSLRLFKPAFSMGVDCFGPMTDKIGRRTEKRWGVIFKCMPTCAIHLNLLESLDTDAFLMAFRRFTSLRDKIGRRTEKRWGVIFKCMPTCAIHLNLLESLDTDAFLMAFRRFTSLRGKPYEILSDCGTNFKGAEAELRTAFSSMAPDLSQQLSKQKVRFQFNSPNAPHFGGSWEREVKSVKAGLRAALGDQSVTEPVLRTVLAEVEGILNSKPLGYVSSDAADVNPITPNMLLMGRLDPNLPQVIYTSKESMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A673</accession>
    <name>A0A8B8A673_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110990687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111471.1">
        <property type="nucleotide sequence ID" value="XM_022255779.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990687"/>
    <dbReference type="KEGG" id="aplc:110990687"/>
    <dbReference type="OrthoDB" id="6774963at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="341"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="627"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="661"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="821"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="947"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1307"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1428"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1462"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022111471.1"/>
        </source>
    </evidence>
    <sequence length="1594" mass="174323" checksum="33573490B5407475" modified="2022-01-19" version="1">MAECPLGNEEQPAAANSPHPDDEVVHEEIASSSSQAPINLHRCTMFLGQYTSNISVNYERSSTTATPRVPSAETPHDYKRDYGRAVKETKFDYRALLQDSGVLSCGEGLFNESAMGNTTRVQEFIARDPESVMYQNKRGNTPLHAAAFGGHMDTVITLVSNKAQLEKKNKDGYTALVSAIFGDEPNVVKYLLESGSKSNTASKRGLTPLHVAAREGHERCVKELLSVPTPSDVNCKDGRGYTPLFIAIKKHYMPTIRLLVEHQGINLGLKDARQRNSLHIAAICGNNFAVEQILKAKPTLINVQGNDGFTALHLAASKGHLDITRTLLQQQICSTYLKSTKGHTALHLAVIEKRYECAKALVDNGADVNAQDEGGNTCLHLAMMKVLTASEAMLESSMKDKDKTAKECDDIQQKMFQLLVQHPSVDMTLKNSKDLNCLHFAAGSGNTFATDQILEVKPSLINTTQNDGCTALHLAVLEGHAHIVSTLVKQKNCSKDVKNTKGHTALHLAIIEKHYECAKALVDNGADVNAQDDNGNTCLHLAMMKVLTSIEAMLDAALKDKDKTAILCDDIQQEMFQLLVQHQSVDMTLKNNKDLNCLHFAAGSGNTFATDKIVEAKPSLINTTQNDGCTALHLAVLEGHAHIVSTLVKQKNCSKDVKNTKGHTALHLAIIKKHYECAKVLVDNGADVNAQDDEGNTCLHLVMMKVLTSIEAMLDAALKDKDETAKLWDDFQQEAFQLLVQHPSVDMTLKNNKDLNCLHLAAGSGNKFATDKILEFKPSLINTTQNDGCTALHLAVLEGHAHIVSTLAKQEHCLKDLKNAKGHTALHLAVIKRHYECAKALVDNGVDVNSTDDDGNTCLHLVMRKVLTSIEEMLDATNKDKAKAETATDAIQQGIIKLLVLHPNIDLALKCNQDFGCLHLASRSGNIFVIDMILRVAPEIINMVKNDGFTPLHLAALNGHKDAVQILVEREECSKDLKNVDGQTALHLATSKKNYACVKALVDSGADVNAQDKDGETSLHLAMKTEMSEQAASKEVPVAKLTEKDVKETSGTNNTEYEQKILETLIQQTNLRLLNNKDYNCLHYAALKGKRFVVEKILEANPSLINTTGNDSNTTLHMAASNGFADILTTLLQKENCQKDIRNASKQTALHLAVNECNLKCIEVLLEYGADVNAKDIHDSTSLHLAIAKISMKNISALSSTKDDGDMDHQVFATIKEYQKVIKLLVEHPTIDLTLTDKTGFNCLHSAAINGNSFAVKIMLAAKPSLIDTTCTADKGTALHLAVLNNHTDIVATLCEKGRNETIPNVNAQTPLHLAADNCNTKSVEILLNMGANVNAQDKDGDTCLHLLLKKSLQEATSSTVKKQKGVPKSSLEIQNLIRMLLRDDRIDVTLRDNNRDNCLHFAAFSGNDDAVKLILKAMPSVINERNETFTPLHIASLYDHADVVQTLAKQGNCNKDLQNCNSQTALHIAIDKNHYQCIEALVNNGANVNIKDSGGNTSLHLVMMKESTQAMLRSASKEELLDIVKKKEEDGSVRNGRTNLVALITSLLKHGANIHLLNNKGENVAHFAPNSSVQSFLEELFERFTSIPKQPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XFV1</accession>
    <name>A0A8B7XFV1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Microspherule protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">58 kDa microspherule protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28 29 30 31 32" type="primary">LOC110973033</name>
    </gene>
    <organism evidence="27 29">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29 30" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Centromere</location>
            <location evidence="4">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
            <location evidence="3">Centriolar satellite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022079130.1">
        <property type="nucleotide sequence ID" value="XM_022223438.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079131.1">
        <property type="nucleotide sequence ID" value="XM_022223439.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079132.1">
        <property type="nucleotide sequence ID" value="XM_022223440.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079133.1">
        <property type="nucleotide sequence ID" value="XM_022223441.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079134.1">
        <property type="nucleotide sequence ID" value="XM_022223442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XFV1"/>
    <dbReference type="GeneID" id="110973033"/>
    <dbReference type="KEGG" id="aplc:110973033"/>
    <dbReference type="CTD" id="10445"/>
    <dbReference type="OrthoDB" id="10262769at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033044">
        <property type="term" value="P:regulation of chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051052">
        <property type="term" value="P:regulation of DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22687">
        <property type="entry name" value="FHA_MCRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000007">
        <property type="entry name" value="microspherule protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037912">
        <property type="entry name" value="MCRS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025999">
        <property type="entry name" value="MCRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13233">
        <property type="entry name" value="MICROSPHERULE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13233:SF0">
        <property type="entry name" value="MICROSPHERULE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13325">
        <property type="entry name" value="MCRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="22" id="KW-0137">Centromere</keyword>
    <keyword evidence="12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="20" id="KW-0458">Lysosome</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FHA" evidence="26">
        <location>
            <begin position="400"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00068815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022079130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022079131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_022079132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_022079133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_022079134.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="55973" checksum="F080B4850D33FE6D" modified="2022-01-19" version="1">MSMSTPKATVQGTGQAPASQTASRPTVTRTVVTATGTASIPKMTPQYGISPLISDSLTKRRSSSRSIKRKKFDDELVESSLLKTSKGKVSSTTSPSGQPPPVEKEEKKEKEKEIVKPPVHHPPVTERRKQVASRPSTSQTHRPPSSHRPSSSSRRSKKPKSLLSLTKDHGRWKPQDDLLLISAVQQTNDLETVYQGVKFSCRFTLKEVEERWYALLYDPAISKLSQQAMRALHPEVKAFVLSKAIYSEDEENLLGTVTSTSQPTVETFQELITKSPTSFHPARTAKALYTHWLLMKQYHLLPDQSVQPMPRGDHVLNFSDAEDMLDDTQLQDQRDDILEHELSVFDRRQKREIRNLENEIVKWQYLVDSVTGMTSPAFDNQTLAVLRGRLVRYLMRSNEITIGRSTSDSTVDVDLSLEGPAWKVSRRQGLIKLRNNGEFYVANEGKRAIHVDGKAIIKGMKSKLNNNSVVEIAGLRFIFLINQELINAFKNESIKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XFV4</accession>
    <name>A0A8B7XFV4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973272</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079653.1">
        <property type="nucleotide sequence ID" value="XM_022223961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XFV4"/>
    <dbReference type="GeneID" id="110973272"/>
    <dbReference type="KEGG" id="aplc:110973272"/>
    <dbReference type="OMA" id="ANYSIYH"/>
    <dbReference type="OrthoDB" id="9972253at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022079653.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="38070" checksum="41B5DCB83C93997C" modified="2022-01-19" version="1">MATGHILPGRGSIVTKFRSKSADPTMSSYRYNKEGRLGGRGTYGRPQYQTSPRDLVEIKRDALLAWTEEMEDWSKSPNKRPTTYEHSYYDKNVKTEDRARMRPISPTRRNKPHPKDVFLTCRLHKVPGYYDPSAAMGKEIGAVQGFQNPDARIKEEVYLVDALCPAWEQEERRHLRHKYIGRPSTANVMTYRDEEREKMKRVISDPWSAQAAEAWLKLAGSTNRKAVKKMVNSARATTQVSNRQPQDRTTRNVTEQVREPYQASVHRFLKGAGHEESKAAEKLFDSLESAPRPLPMSGPHFHITDYSKVHHKIHPKHIRTDFTIHPEWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJ11</accession>
    <name>A0A8B7XJ11_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase</fullName>
            <ecNumber evidence="14">2.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110973580</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81643"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="Rhea" id="RHEA-COMP:19720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="ChEBI" id="CHEBI:231970"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-O-[N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81659"/>
            <dbReference type="Rhea" id="RHEA-COMP:14417"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:139598"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81660"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminyl-(2-&gt;6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11136"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:140764"/>
            <dbReference type="EC" id="2.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11137"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022080181.1">
        <property type="nucleotide sequence ID" value="XM_022224489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJ11"/>
    <dbReference type="GeneID" id="110973580"/>
    <dbReference type="KEGG" id="aplc:110973580"/>
    <dbReference type="OMA" id="NERELWL"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000015">
        <property type="entry name" value="Lactosylceramide alpha-2,3-sialyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941:SF8">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022080181.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="50867" checksum="4EF9E02119791041" modified="2022-01-19" version="1">MAILRMLCKYQSLKVSLGAGVGIYLLLTLVSFGFNKVIWSPRVVHRDKFNTNFGDHFDKWVAHRQHLPRSSVFDANSDRIFYSNIQGYSDKKLSSSRTKADGSFAELKRLFGVDVFGGDSSDVNPPMLPPSLNLDEVPFMRDSHYKPSECPKTVSSITKYSRWFRERFQPDIKILLERTDVDVYSDYYKLLHYRLPFGLRLSNKTQLTTILNHPSFTNLPLYAEGRPQGCLSCAVVGCGGILNGSGAGAEIDSHDYVFRLNRALSTGRYAEDVGHKTSYYTFFPESMHAKDVEDKNATFFYAMFKAYDLDYAINMLNNDDPPRYFSRGRLYHLRKPNIDKRKLKIIHPDFFRYVFTRYLDNKAVRPTTGAIVVFLALHLCDEVDIYGFGYDPRFTLHYYDRTFQSHTDWGTALHDVDNERELWRKLHEEGALRLFKRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJ14</accession>
    <name>A0A8B7XJ14_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositide phosphatase SAC2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973889</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080789.1">
        <property type="nucleotide sequence ID" value="XM_022225097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJ14"/>
    <dbReference type="GeneID" id="110973889"/>
    <dbReference type="KEGG" id="aplc:110973889"/>
    <dbReference type="OMA" id="IGMENHA"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045334">
        <property type="term" value="C:clathrin-coated endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001135">
        <property type="term" value="P:regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="164"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="580"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080789.1"/>
        </source>
    </evidence>
    <sequence length="1231" mass="140710" checksum="B26B3987B1CF418A" modified="2022-01-19" version="1">MELFQTDDHYIVQDGQHSLWCSRSDGKLDPQEGSALANAWNPVCLGTVDGVIGKIKVHPDSSWRLLLISGQRLVGSLPGGHHVYCITRIAILPLSESSHPDIDIERCSKHHFGMKKTKMIMKPATAQQKALTKTWNSIKAVTQVRKKEVKEREKHERRITEELLKMFTDSEWFYYTRTGDLTNTLQRQHTGETKHDWDERFFWNQHMLQDIFACTDKDLAGHWTVPIIQGYVSIRACKMIFEEEDENGLSSSWTPEELSEFKLILISRRSKHRAGTRYRRRGIDGTGACANYVETEQIIQTREHSVSFVQVRGSMPVFFTQPGIKYKPPPRLEKDEDETRPACEAHFEEQTALYRRVVIINLVEQVGREDIIGQAFMKQVLLLDSPLLTYVTFDFHDYCRGLKFENVSVLIDSIRDIIKDMRFCWIDGQGVILEQRSVFRVNCMDCLDRTNVVQTALARAVLSMQLRKLGILLPDQRLPPTVKQTYQDMWASNGDIISRQYAGTAALKGDYTRTGERKFTGMMRDGYHSANRYLQNQFKDAYKQVTIDLMLGNEEVLEDLSVITEQKVSDEEAAEEVWSNVKEENITQLTQHCLKLLVPKHEVKHYIGGWVLINCDPIDPEESDEEDRDVILLITEKAYYIANYDDEAEKITQYERINIEDMEAIGIGSAAAFFSNTKDKCIRVYHSFCGDGDYFHTLKVLPGRNKHESDDILHNVIEAFARARSSNTLGLKVIEDKMERKARKVPQELIKLTSQKRLTMWLQDKFVPEMVIKKHSEPRDRQPRRPASRPGPRTAAVSRYLQSVSNKVTNLNLIQRARNKKKNLGNVPHTLIYQKSTDSDATEEDGSVRIDCDRNDVDTYDDFDDSPYSSSTDTSYDALSIGDCLEILGGNIPNYPQENPDDPIMLNDGDIMLPTCGELATDPCRNQRSFKRRHITPRKKHSKGHAAYDDRIVDPDKSNPDGLVECKDADLKLDYDNDRILDQAKQVDKVSSEDGVTNQDGMSELSDSHLPDHKTGIDSKSEALSLHDQRLQDSMNHETADEGKISESLQHRIPEFHDHLPVDSRSFSENGRSGNTLAEDEASIDYEGQRSGSPLFKPELQVSELANDNDEILVTMNPLPEVLPIDLRDLKTAPRSLVTKSPHKSHSENSLADLLAGKGNQEMEKAADVDNTAQTKEEEQTQRKFKNPFRNINLNMNFTRASSIRASQRKAKMLMEMQMRSQNCRTRFLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJ29</accession>
    <name>A0A8B7XJ29_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ventral anterior homeobox 2b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110973901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080804.1">
        <property type="nucleotide sequence ID" value="XM_022225112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJ29"/>
    <dbReference type="GeneID" id="110973901"/>
    <dbReference type="KEGG" id="aplc:110973901"/>
    <dbReference type="OMA" id="NRLMTSW"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF28">
        <property type="entry name" value="E5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="168"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="170"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022080804.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32095" checksum="264615038AEB4111" modified="2022-01-19" version="1">MEMWAQSYWPAVYDYHSYDIYDKMHHYRQVTYQQLPVYRVPPVFRTAKTTPTPPSDSHSSIGSDVRTASPHRTAEFPRLDGSFDRQRCRVSAVDVESVERTKETRQVRCGSLGAGDGGKTEASSRRESTPHRTGNDTPDTHSFCRVLTFQDPNGRPREMVFPKALDLDRPKRARTSFTSYQLEQLEKEFKCNQYMVGRDRARLATNLDLTETQVKVWFQNRRTKFKREQCKAAEFKEKNAESIAACNILKLLQSQQGDTATVPSVGSVSPIRNRLMTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJH5</accession>
    <name>A0A8B7XJH5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110973984</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="term" value="P:protein polyubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XL67</accession>
    <name>A0A8B7XL67_ACAPL</name>
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        <submittedName>
            <fullName evidence="20 21">Deleted in malignant brain tumors 1 protein-like isoform X1</fullName>
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        <name evidence="20 21" type="primary">LOC110974308</name>
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    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XL68</accession>
    <name>A0A8B7XL68_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ectonucleoside triphosphate diphosphohydrolase 8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110973952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080907.1">
        <property type="nucleotide sequence ID" value="XM_022225215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XL68"/>
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    <dbReference type="KEGG" id="aplc:110973952"/>
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    <dbReference type="OrthoDB" id="6372431at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24044">
        <property type="entry name" value="ASKHA_NBD_NTPDase1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="221"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022080907.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="57859" checksum="7E7E29C81840A0B5" modified="2022-01-19" version="1">MAKTRSNFGLVGLIVAGTVLLVLSIIGLVIIVKSKEFYCSIERYGVVFDAGSSHTSMAVYQWLDETTNGTGVVSQLAYVRDCTEEGIGFYADNPEEIVPGLEKCLDSAEFVLPEFGHWDTPVYLAATAGMRLLTETNPDGSDAIMKTVRSTLASSPFAFEDQARQAAILSGETEATLGWISSNYLAGNLGVEPATGDSINDLTGSKTIPTKPTVGALDLGGASTQITFIPEDPRKIPVENRANLRLYGKDYVVYTHSFSCYGANEARRRVQASLVKGSGFADVTSNPCAPLGYNYTLTSANLWKAPCSARPNVPGVSDELMDKTEYQLTGTGDPEECYRIIKTLFDFDAECAVPPCTFDGVHLPPPFGAYKAFTGYAYTWSGIGLEPSPTIEEYIEKAEEFCRLTYSELVLLGKIDKYNLRYCFQSMYVRALLLDAFKFNQENWNIEFTLEVNGVTLGWDLGYMVDATNRIPEEAACVGLTPSIFAGLVVIFIVICILGIVILGLSITNYTKKSGSSKEQSYQPAPQNVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM58</accession>
    <name>A0A8B7XM58_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Solute carrier family 41 member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110974152</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC41A transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081247.1">
        <property type="nucleotide sequence ID" value="XM_022225555.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081248.1">
        <property type="nucleotide sequence ID" value="XM_022225556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM58"/>
    <dbReference type="GeneID" id="110974152"/>
    <dbReference type="KEGG" id="aplc:110974152"/>
    <dbReference type="OMA" id="WDPDNVT"/>
    <dbReference type="OrthoDB" id="5791097at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000001">
        <property type="entry name" value="Solute carrier family 41 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.20:FF:000002">
        <property type="entry name" value="Solute carrier family 41, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="entry name" value="SLC41 divalent cation transporters, integral membrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045349">
        <property type="entry name" value="SLC41A1-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228">
        <property type="entry name" value="DIVALENT CATION TRANSPORTER SOLUTE CARRIER FAMILY 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16228:SF7">
        <property type="entry name" value="SLC41A_MGTE INTEGRAL MEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="MgtE membrane domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="187"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="SLC41A/MgtE integral membrane" evidence="10">
        <location>
            <begin position="405"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022081248.1"/>
        </source>
    </evidence>
    <sequence length="564" mass="60599" checksum="071AB7220ABDCBB7" modified="2022-01-19" version="1">MPTGKPSAVTKQGSSQLGTALRHRTLAKVTGTDSETMVPRIELETFPSPGDASQVPGMVQAVKDNESAGMDRTHLWNGAVSCQMDTDQGGGGELSIAIGNRAHDDDEDAEIETSFTEPLLHRHSEEEAGDHEVGVVDHREESSFSIALQVFLPYIIAGFGTVGAGLVLDIVQHWPVYIDVTEVFILVPALLGLKGNLEMTLASRLSTAANLGSIDDTKEQWQMIGGNLALTQCQALVVGFLASVAAAIMGYIPDGEINIYHILLLSASSLVTASLASGILGSIMVAVVLLSRKCHINPDNVATPIAASLGDLTTLALLSWITSLLYRAIGEDESVRRLWLAPCIIAFFLLLLPLWVWLSHRNKYTHDVLYHGWSPVIVAMVISSCGGLVLDVAIRQNAGVAVFSPVINGVGGNLVAVQASRISTHLHRLGQPGTLPPGRKGSCLNPCKAFFGSDEHSRSCRVLFLMVIPGQLIFLFFISLVKAGHTSITVRVTIMYLTVALIQVGILLFTANWLVHLLWKKSKDPDNFSIPYLTAVGDLLGTALLALGFYLTWLLGDRDSDVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM87</accession>
    <name>A0A8B7XM87_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110974063</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081085.1">
        <property type="nucleotide sequence ID" value="XM_022225393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM87"/>
    <dbReference type="GeneID" id="110974063"/>
    <dbReference type="KEGG" id="aplc:110974063"/>
    <dbReference type="OMA" id="ANTICDE"/>
    <dbReference type="OrthoDB" id="6107575at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081085.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="35365" checksum="DAC4E0D255956621" modified="2022-01-19" version="1">MLSSSRESLGRSSLPELPFYSRKPATVKIPKSWQFLSQQQRRENWFDSHSIYAKKKNSNSLPRPGHRDVLTREATDVHLRREQGYMREITGFPVIPHISGSASHRRGRSILRRQTANNISQEYRWVHNGLNGKMVLTTQRYRHILPPPLSNHREKDSHLHYCEVLGQRTCSQCVEEANRQMAAEYQQEAFPGLEVTAASLVAPKLSKTMMSSRDSPRKQATAPKSQLSLNPFDTATTPPPYRISSAFTQDRYQISISKEKMLKSLMKTLRRDRTQMRETRTVGKVPQLQRIKSNPSSSLPTQTVKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMZ0</accession>
    <name>A0A8B7XMZ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110974195</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110974195</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022081345.1">
        <property type="nucleotide sequence ID" value="XM_022225653.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974195"/>
    <dbReference type="KEGG" id="aplc:110974195"/>
    <dbReference type="OMA" id="DNSACWS"/>
    <dbReference type="OrthoDB" id="10068766at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2182"/>
            <end position="2205"/>
        </location>
    </feature>
    <feature type="domain" description="PKD/REJ-like" evidence="6">
        <location>
            <begin position="1418"/>
            <end position="1852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022081345.1"/>
        </source>
    </evidence>
    <sequence length="2383" mass="258148" checksum="C6CC4284A5E1F296" modified="2022-01-19" version="1">MGELCQHVVVHDFNQTYVPEDLVNNITNNLIEIAYNEDECLRVGEIIFEELFEGEASDLNMTAEMCSVLVSAFGANVTDNVFIVEQDIIDYIFGLREMYNYSAEPPSRSSDESLEELEGFSLTLGANTTDELLLRWYSVFDPSEMGPYAVIEYLRPDLLIQLYGRMYNARNSREAFKLLCDSLSPAIRGPDLNEMCKEASHQSFDRVREVCSYWGYYGLAELFDWDAYWEVFYLDWYLEEWDRNENETRFWFMEEIRWPILEEFDLYWSPFPICRFFGEEIVKTPSQVQDDVYRALERVVLRSFNSLIDEPCRRIKENRSSDFVENFGDDHPEPRSIKDYVLAMYTYMGGFSSPLAFCTSLYDITENLWEIQPDQVRGLLDTMKANLELVATDEETCGEFVTVLTDLDAEFSISDWTGFTDADTFCVALVDAAEGDGPSVQWSSLVDMALNIEPAGSSSELPPGFLLEEVPVKIVLASLGVIWNSGTVIEGMAIVCNNMVPLLAELTDLSKGEINEMCGALSDSDIKIVQRKCEAVLTPYFYGEHYPTAGMAELDGEALLEVMKDTLGWESFDQEGVCPGVESLLNADFGFVDLFVTMMEGILPYIGTESALPFCHNKEQIKAFWQGTGPFYDESRSDYDERLREAPKPDIEYDLLDSILGVATGMGSIDSICDDLMEADEDGETSAFYSRVIDGVFGLVNNVDRCTVAAETMLNLLLPELDISSSSESSSLVPWADPIYWATGLRTPKAVCTKIVQSFTGQQAERCRGIVDCAGICNGNSREDCAGVCNGGATYDCAGACNGGAFINNCTECVGGRTGRAVTFGMDKCGLCRKAPGYRKTWDCHGECDGSAEVDRCGQCVGGTTGLSLDTNAGRLDCREVCDGGWVADTCNYCEPPAKQGVVYDGGSKYKDCTGGCIRPGAPRAEENDCGVCWGGSTGVLETEGVNVCGQCESSSVADVMSCAGCDGVPASGVEYDACGVCGGDGTDCVAVGLVIPNIVPNVQTRVRVAGAGFSAGALLTCLFTLNGQTTEGAATRIDTTILLCDVPALTPGDYAVGVRRNSDLPSEITSTLRVFQDVEVVEISPTTFTVNRSLETVEITVTVATGGLASLRAYSEEWNVIPTLTVLLDNGFLRSFGTFESDETMSFLLGMPYNSGYGVVVPSVNGGATALGEYSVNGYAYFQAPTLERIQFSDTGASLLVTFDMPVDYENLRSCKQIFTSTQSLGQGALCLWLYPTAMLILIGRGSNLVEIGSPLIVKPEALKAFRQDFSYAVESKSYYAQPPNNPVQPEAVVTGPPKLPSCGNIRIDARRSTGSGGRAMSYYWEVESTGSTTSLDNALNDINTNSPSPSLALDGDLMDADTDYVFTVNVTNFLGGWDVASLTVHRTGIAAPEVKILSSGVDLTSVRVSNSFELTAQVKFYSECVPPGETLFEWSVNNTDVALNLKTQYTRSLNVPAYSLPAGEDLTFTVRVYKSSNPSAYVEASIGATTVSSPLVAVIRGPSELTIGRDSGEVVLDGSLSYDPDAEARDWEYEWLCVQTDDNSACWSYDPSSIGTLINNGSNIDGAYLRFDALSLQADKSYTFTLVASKEARSATASVYISAVNGNPPKIEIPPRSDNGEVKDNRPFFLSAIIRHSTDLANVTWETTDTDSGYGFLDFDETSNLLVPATVFPMGNGVSAALLVVKDGVVSRGTSYSIRINATTIDGQVNSVKTYISVLSGPTSCDFVLPDNYTEFEEVTFSIENCVSTAEPLQYQLHVVKEDGSVAAFKDTTPEPTFTSVGAPRLSGSNIRNYVMKVCDSNDICSVYEGNVTVLEKVTFTEAEVTAYISDQVDTPKFAGDFSLALTNLNMVSDRGLVSRRRRRTAAEDSTSTTTTDQLELIQLTIDETVMTPSRAQLLLDQTESVDPTTMVLADQSDFVTQLETIIDVFIGADEPIPSASATTVSGKLDVISEGLDPVYHESILAQISTVRSKLASSLASGLSVGSPRSEIDGTDGVSSVMRTLLSDPIDSKTSGTPISINFGSEVAELFSASWICSSGESCSGVTLKIQHYNTGVDLLSTEDDHINYRVADILDIVLTDPESDEKLNISGLTTPILLNFTITNPLSEVDNECVYWDGTTWSTDGLDTTENGDGTITCATDHLTTFTVMGVPWPSVPTTEADEIVTAVPENLFGLSTELIIIISASAAFGLILLTIFTVFLCKHCGKSKAKVSARDVPDSIQPQVQPQMQPQMQPQLQPQQFQLQPQPQPMVALIGIPVIQGQYGMGYNHTSMAAVPRDAPPVYDIPDQGYSTQVGGAQPYGSTVATAPPKVTLVGNNNNLVQVGMASDPPSSYSGKAAQSGEMSSYLTAVTSGLPGIGGTEHIAMKTVSGSKASLTGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR48</accession>
    <name>A0A8B7XR48_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere protein L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110974864</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-L/IML3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082466.1">
        <property type="nucleotide sequence ID" value="XM_022226774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR48"/>
    <dbReference type="GeneID" id="110974864"/>
    <dbReference type="KEGG" id="aplc:110974864"/>
    <dbReference type="CTD" id="91687"/>
    <dbReference type="OMA" id="TACKMDQ"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025204">
        <property type="entry name" value="CENP-L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31740:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13092">
        <property type="entry name" value="CENP-L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022082466.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38855" checksum="B8CAB8EF3B86634D" modified="2022-01-19" version="1">MLHVFGHDIHVHDMASPTATHTPPSQVVHFDSTSNASHGRSHSSSSRRTTWPARRHTPYTKTPKSRRLHGKSSRLERTPVVPAGDSHALKQLTNKTWHVYQVTPLNNFQHSVAALRKYSRHLSATLQAIGITGYDNDPEAVELTIKSRGQGRGANAKVIFNAIFCCVGWEHRGQLAEGLTMLPVLLVKGTAAVTRFVLSWLQVQFDCHVKKMTFNPVALVWMVSMWAGLSTGEKSKTVELLYTVPKTVEGLSRITMTIDATDAKILWDSVHDEGSADFTADEVTAFIKALEAHFFHHFKIHLAALTLSRIGTPIVYIGSEGRLKILSQEGTRAVLQHITELAVDNFCRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRY1</accession>
    <name>A0A8B7XRY1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Leucine-rich repeat-containing protein 56-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110975425</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083609.1">
        <property type="nucleotide sequence ID" value="XM_022227917.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083610.1">
        <property type="nucleotide sequence ID" value="XM_022227918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRY1"/>
    <dbReference type="GeneID" id="110975425"/>
    <dbReference type="KEGG" id="aplc:110975425"/>
    <dbReference type="OMA" id="CGTHDLS"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040091">
        <property type="entry name" value="LRRC56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22708:SF0">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="270"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083610.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="70699" checksum="2D5B953DEA9D6005" modified="2022-01-19" version="1">MASVHITDFGSATVNPQPIPVEDTEFLLEDYLSSAKMKEMTGVDDLDDVKYLEMRVDTTETSLGNFGTMVPNLKYLKLSNSIIATVRDLGTSLENLSVLWMPRCSLCDLDGMGSMSSLQELYLAYNTISDLSPCSMLESLQLLDLEGNNIDDMSQVEFLSLCPKLTTLTLEGNPVCQAPCVDYNKDEEGEFDYRAATSKAIPQLTILDDDPLSVVPSSLGRTSANISMEWLLVNEAIKDQGSNEKLEVEDGRPGTARPSSASNRRPGSTRPGSARPGSARPGSARPGSARPGSARPSSSGARPGSSLGTRPGTASGTRPGTAQGERPDTGGSDIHPTQEDASDLTHGSGGVICGNPVRALRKRRRRNKDTTPPYQPASIFSMFQHQPDHSYVLEEEEDGKSKEDIFAELTEWKQQHEAKILARIKESEPQVLKIHHSDDDDSTQDYFNNLGYDEDYRLASPSPTSDYPESLASGGMDREPTPPLAPSPKIPQAPKSRATVRPKTANDFRSRRVRVRSFEDNQGLDQRLQDMHLSMDDDMEASDSGQTSPAVMQYSPPPIVPAENRPFSGPVVGTRKFKINPENSKPEPKNIDRHQPVIRSSINTPPNLAYRLSRLARPSTARAAMQLQRPPRLPSREPRFNSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XS85</accession>
    <name>A0A8B7XS85_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083719.1">
        <property type="nucleotide sequence ID" value="XM_022228027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XS85"/>
    <dbReference type="GeneID" id="110975492"/>
    <dbReference type="KEGG" id="aplc:110975492"/>
    <dbReference type="OMA" id="KIPWRYA"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="79"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083719.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="48259" checksum="232436B0A0820B38" modified="2022-01-19" version="1">MSLSVSPKSSVSQRARAILTYEASCAVPAAGGIVGKGEYHAEENPNGMINMGTAQNIMMYDLLREKLDCSMELPRTWSDRMFKYGETEGLPELREAIAKLLTITSHAAKPLDPNKMVIMNGGDVCLEAMAHVLCDAGEAVLVPVPFYYGLGRSLKLRPNVDVVPIPLFKEPRPGESQPFQLTADRAEEAYQKAVSEGVTVRALFLVNPSNPLGDVYSRKQVLDLLMFASRHDLHVVFDEVYMSTIYEEGVTHSSIFQFREDEIPDPQKVHFIWTFSKDLAMSGMHIAVNYTWNDEVCKALTSIAHFHAAPTGWQQAMARMLSDSDWFVNVFLATSVKRLKEAHSFFTQGLSELGVPCHNGGAGLFVWADFSKFLSAPTAEAEEELKQKLLRAGVQGTPSAVCLGQERGWFRLVFAKDKDTLETALARMQKALKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUG9</accession>
    <name>A0A8B7XUG9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110975454</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110975454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the apolipoprotein L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083660.1">
        <property type="nucleotide sequence ID" value="XM_022227968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUG9"/>
    <dbReference type="GeneID" id="110975454"/>
    <dbReference type="KEGG" id="aplc:110975454"/>
    <dbReference type="OrthoDB" id="10135721at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008405">
        <property type="entry name" value="ApoL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096">
        <property type="entry name" value="APOLIPOPROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096:SF28">
        <property type="entry name" value="APOLIPOPROTEIN L, 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05461">
        <property type="entry name" value="ApoL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="62"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="299"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="677"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083660.1"/>
        </source>
    </evidence>
    <sequence length="828" mass="91101" checksum="2B6CD8BC2BC203E2" modified="2022-01-19" version="1">MLRFYSCSNYYICRIVCFSSTIHIDRSGNSTMPSWGLRLCCGILIMLSTARLCAAEYKVCPPEFETSIHETFGVSNYLQKSAWQRIPCLSFRREEALDGVIWYKGSNINDRSKIRLISRDLRGDGVKDIPSSARYSFSSDSSLVIKGVEESDEGSYICQVIPQITDSRVEKIDVQVIGETFPAHASDKSSTTSFQRGRRQMLPCQCAAETPVPHISAVYWSRGEGVTEHTTIIGVRFSDDAFVQIQDHADYTISSKASLIVYFPTDGIGNQRFWCHVFMSDNTQSHCHIDVRWLDEQKPDTALKASESSFYLLEGEEQSIPCLSFTGSSVCEIEWFKIDSAGQNLLASRNEFNADSNFDLANDYGLVIKSVDASHAGRYRCRADQGLSEETSVYVIGDKFQLDGSKVFVYSTIDYVVGKNNTLTCSGASNATEIQGGTTIIWSFGTPTKQTTTTVIGRLALPERSKVMSGAGDKACYNISPEGSLLLNNCSQNSDVRYWCHVFFEHGLLIKSYVDVLSNEPETAGKFPIVVIVSVIGVLVALIACALICRKMRSSHSTMMETECKLKVLFGPLEQDVRNFVHRRKDTIQMLRETADHLTEVHREAEKAKRGGGVAGLTGTALAITGIAASFFTFGTSLYLAAAAAALDATSGALMVAGHFIQVKSSNDAEKKVEKILKDDSEAMEKVEHRLEEIESDINEFSSRGQVALKTASSVFEFVRVGRVVVSAGKSVGQSASKVAFTFGKGLAIGSALLSFVSVPLDLHTVITCSENLKNNTIPELAKSINELVTKLTEDCPQEQDIEVVINDMRVKFCAPSKQKTNCCKCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUP0</accession>
    <name>A0A8B7XUP0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975503</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083735.1">
        <property type="nucleotide sequence ID" value="XM_022228043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUP0"/>
    <dbReference type="GeneID" id="110975503"/>
    <dbReference type="KEGG" id="aplc:110975503"/>
    <dbReference type="OMA" id="AYNIGTY"/>
    <dbReference type="OrthoDB" id="5870230at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF519">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="157"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022083735.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="26931" checksum="0CFA13B942DA7EC4" modified="2022-01-19" version="1">MGGKEGCVMCLRCLMVFFNTLLWLAGVAMLGFGLWLRYGQQFFPNLSPSGDEDAVSAVSAYNIGTYALMAAGAVIMAIGILGCCGAVKESFCLLGLYFVILFLLFGLEVGASAWIYINRAELGNKVGNYFEWLVTEKYDEDKATQVAVDYTQSSLECCGANGHQDWLESGQTIPVSCGVVNCTSDCPEDETLFDEGCKAKVSSIIQGNIFTLVGVCISVAVAQILVMILAVCLCRAIRQADLEYDKCGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWG7</accession>
    <name>A0A8B7XWG7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RUN and FYVE domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110976004</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma. Positive regulator of macroautophagy in dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger. Positive regulator of osteosclast bone-resorbing activity, possibly by promoting late endosome-lysosome fusion by acting as an adapter protein between RAB7A on late endosomes and LAMP2 on primary lysosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084597.1">
        <property type="nucleotide sequence ID" value="XM_022228905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976004"/>
    <dbReference type="KEGG" id="aplc:110976004"/>
    <dbReference type="CTD" id="79443"/>
    <dbReference type="OMA" id="KERCCSD"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071353">
        <property type="term" value="P:cellular response to interleukin-4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072383">
        <property type="term" value="P:plus-end-directed vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901098">
        <property type="term" value="P:positive regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051050">
        <property type="term" value="P:positive regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15726">
        <property type="entry name" value="FYVE_FYCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000341">
        <property type="entry name" value="FYVE and coiled-coil domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.900:FF:000015">
        <property type="entry name" value="RUN and FYVE domain containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047337">
        <property type="entry name" value="FYVE_FYCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753">
        <property type="entry name" value="FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46753:SF2">
        <property type="entry name" value="FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RUN" evidence="16">
        <location>
            <begin position="33"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="1237"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="17">
        <location>
            <begin position="1479"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="463"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="630"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1299"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="223"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="762"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1089"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1299"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1328"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1421"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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            <dbReference type="ARBA" id="ARBA00023228"/>
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            <dbReference type="ARBA" id="ARBA00023329"/>
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    <evidence type="ECO:0000256" key="10">
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            <dbReference type="ARBA" id="ARBA00059075"/>
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            <dbReference type="ARBA" id="ARBA00069100"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022084597.1"/>
        </source>
    </evidence>
    <sequence length="1612" mass="183592" checksum="7435D6165795E2F5" modified="2022-01-19" version="1">MAQPRSYPKIVQDITGCVQDLKKDYNDTKLPITDDSQTLHKFCAKLEYLLQIDMKGRTSILGGRRDYWDYFYKCLSKVKGLNDGLRFVRAMAEVKSSLGRGRAFIRYSLVHHRLGDSVQQCISNVKVTSDWYGPTAVLLNTVHSSTVVNALYELNDIQFDLSPTGYDLDTAWPTFARKSIGAANLFLWQPPSRTTSTSSINSQQSASDSYPNSPMIESRPSFLEDQLTRLQKEFEECEQVNRQLRGRIDQLEQDNEELHQMAQETEEQMTCFRSKSERETAELQDQVEMLEEGLNAKEEELFGLESQWKEKLQEAEKTASDLYARIEVLNKQHDSREKMLTESERDLREKLQLTESSVSELKQQVIAYEADLAVRTASETSNKEKVSELEGKLADAENRNLELITRMDSMVQNKDKTVSSHFESASRVHELLTRLEGAETEKLQLQGIREELIRKLELVEMEKTSEKESSSQRQEQSTNKSKGSTETPNTEHYLQQIKELETLKLQLASHNSELAKKVHNLEAALQNSATEKIVVERQMNELKKTVSNLEESDCVLREEKADLQRQVSLVEKERDEAVRKATFLEDGNKKIADLEKQLRKSQQEVDALKIQTSKLHNLESTFQQLLTDLETQEQSRSAEPSADSQVHSEAYQTSASDTSGSTELRGDGSPIHSLQLRINSILADKATGFSQLQGAHREVTDLKAHNDELVKQLGTMKEKQQRQSQEVCDLRDTVARLQGELADAGLRSESQKQVLNVKDGELKSLAQQMSCLQQRVSDLKDGVVQKSLELETHQQKLEQANNQLKSFKVSLEKARTEKETLSSKLSSTETSFEALKHEHGGLQSKTQELETHSQEIQEDLEKQKQAKRELESMLEDTRRLVEENVSLEQVFEERKQKMIKEHEDKVEFLTHQFNMIQEETEKANTEKFRFQEEHKVMLGEVQEMREKLELMETERNEIKKTNDTLNTEIARVNEASQLANVQKEETSQKLEQLRSEMFEALEENTTRMLRLENVLHDTQEERDRAKLRISDLETELTEAREKLLQAEQKLEESTQQLTNLECVRQQEVSALKFQLSSEAMEYQQAIQGYKHQETNLQGLQDRCNEQEEIVESLQTELNLARAQLEQQQKQCKDAQELATEKQRESSALQEAIQQMSKTLEELQVQNLNSEEELTQLRVERQGKQTSLESKVVELENDNVELKKQIIKLIKDKDTLWQWTDKLDYQRKMKASERWIDDSEVTQCMQCHVEFSLIVRRHHCRLCGRIFCTKCANCYVSAAHSRKKSRVCEQCFVIHQQANEPDQVPPSTSISLDSDDETERETLARSRSFIGSSSPLSEGRQSVPTTEASSSLEGAAPGRASPEQQGSAGGQAGDSTAEGKTLQDADQKLKQRGWKGETSLVTGSESSYYSETEPPENPVIVLDSPLPSRRSLQSSSDRDEPDFDLISEEEISAVRNSISSPLDSPVVGLRSPRLAEKSTFTCPTLHMSELESGNKADDDITIKAGQSYAVPIHLDSPGITLCWEFASAPKTVAFSVTYQPADSSPTDESQGQQAHVDELIPLCKCNSHRHAVQGELMARKAGIYTLLFDNSFSRFTQKSVKYSLQVKRPEAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY24</accession>
    <name>A0A8B7XY24_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">A disintegrin and metalloproteinase with thrombospondin motifs 6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110976312</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085162.1">
        <property type="nucleotide sequence ID" value="XM_022229470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XY24"/>
    <dbReference type="GeneID" id="110976312"/>
    <dbReference type="KEGG" id="aplc:110976312"/>
    <dbReference type="OMA" id="MVLSHTI"/>
    <dbReference type="OrthoDB" id="9936463at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="9">
        <location>
            <begin position="60"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022085162.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45862" checksum="FC1C28D881C8B4DB" modified="2022-01-19" version="1">MFLKDVPFYFLILALNEAFSYRLSPTVKQRNVQSASKQQFKTDLQIPNPDVQIVSSRRPISLDLLVVVDTSSYRYHGDDTEHYIMNMLNVAASLWQSSSLPADVRVRIVKIHVLKEKHQSDLELTDHANWSLMKFCQWQRQYFMTRDKERVHFDAAILVTRIDIQIGGNYDATGIAYNQGMCDLEYHCAICEDKSPMILSHTITHEIGHLLGMRHDGNQNTCPDRVFIMSGYATRGHQTFIWSTCSQKALAEFLSSNRARCLDDALSASRTPGVALDTNAMPGRIYDADYQCQMIYGATAKACKEQNKTKMCGMLKCQKDEKRSECVTDGRPALQGTSCGSLKWCLRAFCVQRTIRSHHDDDTAIAYRQNDQPTDGQYCNECSTFPYMDTPAPTTNQDGVPLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYW0</accession>
    <name>A0A8B7XYW0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC110976443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110976443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085437.1">
        <property type="nucleotide sequence ID" value="XM_022229745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYW0"/>
    <dbReference type="GeneID" id="110976443"/>
    <dbReference type="KEGG" id="aplc:110976443"/>
    <dbReference type="OMA" id="TENSTHR"/>
    <dbReference type="OrthoDB" id="5969463at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF59">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="164"/>
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    </feature>
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        <location>
            <begin position="176"/>
            <end position="197"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="360"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="43"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="303"/>
        </location>
    </feature>
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            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022085437.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="46981" checksum="2C5E2815D37BDA4E" modified="2022-01-19" version="1">MASTEASSDSDLPPLPDINNISKELAICRVFLNTFILISGFLGNSLILLVYKSKMRKNSTQILIMGLAGVDLTVCLCRIRNIFKFSYMALDRESPLITEVFAVPGRFALGMSGVLTGIIAFDRYDSVCRPHRRLFNRRRAKIALLGSFATSVFLEMPNFIGTILQSPNWRKTSHSIHITEYLIVLFLTIVCYGNVYATTRRRAKIRAEFLPPKNPVIPTISYKLNMQPDKTDASAIKTEFASTYKESSTPTPHASKPSTMFTTLKSSSSKSHQTFNAHKSAVEKSTPKELPLQNPPSAGVDTQEQRWAYRREVQMHIRLGKPHQTNPPLMRDFMQRRVTRMLFITGVVFLLAWLPYWIFIAADLFALNGGTLGEGVLAKLFSVAISVPFNSIVNPLIYGVANRHFRKECAVFFRRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYY2</accession>
    <name>A0A8B7XYY2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Uncharacterized protein LOC110976357</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110976357</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085244.1">
        <property type="nucleotide sequence ID" value="XM_022229552.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085245.1">
        <property type="nucleotide sequence ID" value="XM_022229553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976357"/>
    <dbReference type="KEGG" id="aplc:110976357"/>
    <dbReference type="OMA" id="ARSTHCK"/>
    <dbReference type="OrthoDB" id="10072641at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026811">
        <property type="entry name" value="CIZ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15491:SF9">
        <property type="entry name" value="CIP1-INTERACTING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="7">
        <location>
            <begin position="1201"/>
            <end position="1232"/>
        </location>
    </feature>
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            <end position="651"/>
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    </feature>
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            <begin position="1649"/>
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            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
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            <begin position="361"/>
            <end position="373"/>
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    </feature>
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            <begin position="377"/>
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        </location>
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            <begin position="392"/>
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        </location>
    </feature>
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        <location>
            <begin position="1591"/>
            <end position="1614"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022085244.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022085245.1"/>
        </source>
    </evidence>
    <sequence length="1677" mass="185213" checksum="4FF4517A97A01836" modified="2022-01-19" version="1">MGPDDIKHILTNLSPQEASQLRNHLLSRNVEELGLTPDQALSILQALEEGDFETKQGASSAPLRAPTAYSSHLVEDVSQLLSNWETVFGSPPPPSLQGGMSGGGSYQTGFGDEVSLIQQKVEMLERKRAQILQQLQGPNPQPYPGYVRETAEWAGPQAKQKMIPGEEGLRGEGPRFFTQAERGNTVVGNWGGSWTNQLQGNHQTLGGNQLTGIKSQADNWKEMQMSNQQAGGPQLPRRRKASRWDLPGSDGNQARGGGNLATGGGNLAQSSGNQVRGGMQQAKGVVGNQAGGDGNWSKGDSQTIWTQPDGDKKTGGTGKANLGNQPRVIYHTGVKKQATASDQERRGYQATGGKQAKGMKQGRGGNKPGGGSQTKGSKNKGRNQTRGRNRTRSGQYRQDGAGDAAQGSRSRSRSSSSRRGYQGRMESDDRGSFRGRGQGPDEDHSWEGGSYDEPGYNYQDRADDYYDGRPRDGSWEGHRDTDYFDQGDTRNDEYKQGDDQRFDWDDYGEDSRDFVVGHDYYRDESRSRPEQARGNKDDYRSDEFRPADADDGRRGFKRKRSASYRDEEAYTLDFAPDSTERGLQNQVRRKRKPKSSRALGYGRREEREGSHEGIRDFDQQYKDWRGDVRSESGDQRSHTGMVSQEVEPFERRHWDSTERSTGYHPNQPEFVARSPSQERFMETGPSLVNRDRQDFRVANQPMPRPLEISVMSNTRRYSQPDVFSPPPLLQGSGFFQSLPRVSNRPVFSPGGVPRTSRPRFRSPKTKTVNRLPKRATGPQIKQNLAKQQAAKATAGNQQIANDITVKLAKMLLRRAKVEPPPTQPAKPTEASSGGNETKAAPSKTTTGTAEMETASTGAAETASDSQDKGTEGTEVAKTGVKAAEAPADNSIPDKREQFSIRTQVSALEDLELHGFLHHKVMTKWTCYICGLVLGNETKFKDHLKTEGHRVKLSSYSGVNSHSLRQKLANRLRTLPNQAKIKPAQLNVGESERVYFCSSCFLGYTCSPEEHRQQPKHQKLQRIRSFCPICNLYLKKRTSTRKHYSGLLHSKMLELRKAEDEAQRRILRDHKLAETLLTRSNQRQKLQEKPQNSSQSQVSGQAAASKTTSALDQAGVGNQKEGSTHGQLANQTQAPKATSKPAPGSTGPTGKTTDLEIRVLKMDKSPEVMSPKLDADSSAKLDSEENEEDLIGLELVIPVTGFFCKCCSKFYNNKYTARSTHCKTDLHKQKVQQWYVHEAEEKVKTDSTDGNTDTTKMDDSKEAAKVETTHSAKDAVIVIDDEDEEDVAEGSQATGKHKIGTQEGDKILSEGISKQEASRTGEGIPFIGTGESQTDDPDGEPASARSGKMQDEESIVEGEDMFITEDQVGHLLPDDEVEVEGSPELGDTASQEGVGCDVQTPMEQELLAQGEELIDEEPADVELLPTKEQNTGEVDPSTVQEKELEEEVESQMDLPGGKKDPEEEVESEMDLPGGQKNECFTKEAETGGKNVDPSIEADEYLQTEEMDVGEEKSLQIDNQELPLTEEEQLPEENKEPSASKELPAEVAVAEEPSQSPTDKMQGGNSVKRNQEVDGEEEPQHEEVTEKPKEACLSEDDLYGDLEEGMYQRDDDDDDAYLVQQDGQMNDDAGDHEDDDEMFAIDEDCWEVRSEEGGIALSSDEDDNGVQGEAGEENKIDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZJ5</accession>
    <name>A0A8B7XZJ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rab proteins geranylgeranyltransferase component A 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976921</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086329.1">
        <property type="nucleotide sequence ID" value="XM_022230637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZJ5"/>
    <dbReference type="GeneID" id="110976921"/>
    <dbReference type="KEGG" id="aplc:110976921"/>
    <dbReference type="OMA" id="GNWAGFN"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000003">
        <property type="entry name" value="Rab proteins geranylgeranyltransferase component A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001738">
        <property type="entry name" value="Rab_escort"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016550">
        <property type="entry name" value="Rab_ger_ger_transf_A_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="684"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022086329.1"/>
        </source>
    </evidence>
    <sequence length="753" mass="82160" checksum="9C97414202C717B4" modified="2022-01-19" version="1">MAAPELPTEYDEIVLGTGLQESILAAALARIGHRVLHLDRNDYYSGDWATFHLRSLLEWIDKHKAPEETGVLPGASDDQDGGGPHDNSQLGEGESFLELPQNCRTVTGLEATCYVRAGVELPSLERVIIPPRLSTPEEEPNLQGAEGQDPSQNAPEAYASSAGAQTGADQSHSEGGDEEAEALQNSANEDRESSSSVSPSISIDQPGTNDVAATEPVSSDQVEGRNSQGEGSSSSETPSEEQEPEPAGQQEQDSQAQGDEGQGSSSQSSADEGQRASATRSERRDWTWAEISQLWRKFNIDLTPKLMFCRGSMVDLLVSSRISRYAEFKAVTRILTVIKDKLELVPCSRSDVFSSKYVSVLEKRMLMRLIEFCLNYQDRLEDYEEFRDRPFEDFLKSRKLTPTLQHFVMHSIAMVSADTPTEEALKSMQFFLRSLGRYGNTAFLWTLYGSGELPQCFCRMCAVFAGIYMLRTNLKTLIVDENNVCKGAIDSEGRRLTCNNLIMESSYAPQHATNTTLGSVSRGILLTDRSLKPTDNEEITLLTVPPPAGQNNPVRVLELGAGSCACPREMFVVHLTCAGTGQAKADVQNALDSLFQPLNSEEADQSSTKPKVLWSLFFSQVDASVCEDSALAVGLPSNVLVTAGPGTSVGFGHAVAQAKRLFERLCPDEDFLPAAPEPEDIIFEDQSKDNPGEHKEVGFEANSSAGETERPKGEETTVTSSETLEQTDRASQKKDVTEAESNQDKSDDTTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZL2</accession>
    <name>A0A8B7XZL2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WD repeat and FYVE domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110976578</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085702.1">
        <property type="nucleotide sequence ID" value="XM_022230010.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976578"/>
    <dbReference type="KEGG" id="aplc:110976578"/>
    <dbReference type="CTD" id="23001"/>
    <dbReference type="OMA" id="GVCHLIE"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000002">
        <property type="entry name" value="WD repeat and FYVE domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="11">
        <location>
            <begin position="2556"/>
            <end position="2681"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="10">
        <location>
            <begin position="2710"/>
            <end position="3017"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="3158"/>
            <end position="3199"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="3594"/>
            <end position="3654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="804"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2501"/>
            <end position="2547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3290"/>
            <end position="3439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="832"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2537"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3290"/>
            <end position="3301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3318"/>
            <end position="3330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022085702.1"/>
        </source>
    </evidence>
    <sequence length="3665" mass="408154" checksum="74492DD0209C60FE" modified="2022-01-19" version="1">MNTMRRFVKNSMRRSPSSAQDNSLGLMHLRKLYVELCCTAQPLSQKEQEDKLYMMLPLFCKVFENSPGHEIIDKFGDVLQFSNHVARLFVTEIRRKASDQSTEAASCSIAEYLEIKSTAESSNGWMLLSTLNLLAGGGQSIVNTMMMAALPSTLVKCLYLFFDLPEISMKNEGGGEGMRKEESSGETITPAKRRELLHKYVVQLLVKLCNYPGPADELAKKDDLTLLFSAITSWCPPHNSPWRKGAAEVLTTISRHGLTQDVVQYIHNKGCLALCVDNMQHVQELTPLEKVEMCFTVFCFLKDSSDKSRVLLDEFRSCQGYIFLADFVLKLESMGDEESIHSLRNLVLLISSLTQCGYTELRPNSGIYEAPFQVQGFTLPQPSGNGNSVRNLQAFQVLQTIFLKATTGSLCAVILEVITNIYNSDNANYFILEPQHTLSQFIDRATTKLPEIQLKIFELLEFVVFNLNFVPYKELSSVSLLIKAGNDVGCMIRSIKCLLRILRHGGVYKDVYREVGLLAVMVTCLHRYAASLKDNQPDTKEEICSVPEVNIPEEDQDLAFLVMDCLTLLLHENNDNAIVFREIGGARCSHNLVPYIQCRQHALAIVQQLILSRDGEDDMGTLLGLMNSTPASQLQLKTDILQSLLNVLRDSHRSRTVFRKVGGFVYVTTVLVTMEASLSDSPKEPWDTAPKDQVFTLLHVVFQTLTAAMRQEPANAKFFASEIRYESLTEDIRRLGCFSDITELLPQAHSPSATNEGSSNTEPFHNLFDIDCNPDHLSDGLRSSCLLLRCLYDTAIDAFSSKSAQTPINSPASSHHVHDAYTPLPTPPSSPAKPRSPSSRLSPRSTGASPPGVSSPLSPSGGPPPPPNHPTIVHPGAVLSMLDLLPSVQCERNRKFALRLQMHIADVIQDLVKSERNQQVMCEHGLPQQLLHLASAALADEEHPLHSNLQHMLERLASQALEPKDLRDFLRLGNPLNCKPLDECSNPAVQPGYLDIPISAIPTSAAAVTPDQQPFTAAVSPDLSDTNSAASSSELSSCSAGARCGCNLCATQGGAVPLTRVKCLVSMTTPRDVRLSGTSVTPAFAEFDMSAEGYGCLYLPSVAPQSTPSQTVVSVGMAAAADSANISGVGTGERAFPPQTGLTYSVWFCVDRYCTLDICTHPVRLLTIIRNAINTDNHSTCLRISIEGPERKLVINTSEEPMSKVDDKLDYDPSAVRVFCPELAQEGKWHHLGVVFNKAVLKNSSVALYVDGTHIHSHKVPYIQTHLPGTTGSPANLTSVYAYVGTPPLQRSMSRLLWRLGPAHLFEDALPSSTLCAIYLLGPTNVGSFQAPRQEEFSPVKVDLAALQLPEEKIVLGIHAHALSVLTISKIRKTFNKFDSKSVAKQLNLSTHENSTPIRIIHNSACHLSGSGRSFGAVLIGNIGVRTFCPKPVASTLENIGGSAPLLGLIAMSTDVEGLYAAVKALVCVVKNNGPAMAEMERTRGYQILAFLLKRKKHLLNSHILHLTFSLVGTIDSGRETTIIPHRTAFEDLLCDLEVWHNAPYDLQRSLYDHFYELLTDSSEADKNRKMMRQLRMVNRLLYMIQDPTLTHATIQSIANLLSVMLQGGSSSADLLSFGQFLASTLPNLSADERMVTLDELQCLVSDTDSQRGSRDNESISEDWTGTVSPHNIHLRNVLLDVILKLLFAPSSHSISPSNCEEIHKVLGYDWLLLFMQSHVHASTVIMGLRILVSMLYSQSAIGKFRDGTYGGGWLEKTEAVLQNRMGVVLGFNLGKGKKGLQNREINQEACHMPGFTVLQWLLPKHASVPELYFLLMAMSLGQPVRELPENCQLDLNSMWQFIFGVPTNQPLSGRVPTNICTDAILVILAQIRAMLNHTVDPDEEIPWIQEYPVTLIQFLLYLYHNLPEFKPVCMSAPFLCGLASTMFPYTANTEQVCSPVEEYVILPSEESSELSSPSDEIKYLPGLGIPVFGIKSPDRYPTQSGNLANHAARRYVMDFLRVIVMDSLSLPAPSKSAPVLDLLLEASPVRASAAQTNEFQTEVLASLMDRVVAGDVLLEKEGALPIAAGGSFGNLINNVFYLSSRVVDKLWQGVFNHKSKEVFDFVAQLINQAKRRGSHGIPWDTIYHCLNRTVLYQLSRPHNTVTDQYSLLESLHQITENRTMLFGPSNSEQEFVMCLCHLLFSLTDDLSAGGMCLHCQSTEVNRTTQWHVDPMYPGTHSESECPEHESSHAQEGQLLVRKASRRVWDELIASKKQFIEEIFKVTLPNSNAGTKGAVSVDLKIARSSMGEAASKVWNSYITAEKRNTVREQQLSSRLSSKVSNSFQLLSSSRKSKRESASFRSNLPSIQEASMWTFTHISIARDLVELQFNQHQESQQHLQRYIEEEWSQMEMELTRERGLWGPPCSSELDKWILDMTEGPCRMRKKMLRNDMFYVNYPHRQDFDTLENKPSKGRKPISFDSRRFWLRQRGQSLLDRGDGPVTEPVIDTDISMEGVEEEAGTREGLCPSSLVTKQGNSRQDKDWEDSETPDIETPVDKPEEPKTDNQMILRLMEEGEKIRHMFRCARIQGLDTSEGLLLFCKDHFYVVDGFTLLSSREICDIDAVPAQHQDPIIPRASRGQRTHQKRTSSKFAYEDIREVHKRRYLLQPCAIEVFSADGRNYLLAFPRKVKNKVYARFVAEATRLTDDTTSVAGQKRNVQVEGGSSFLGLGNLIGETTVTQRWERGEISNFKYLMALNTIAGRSYNDLMQYPIFPWILADYDSEELRLNRAATFRDLSKPMGAQTEARLQQFRKRYDEWEDPTAFSSLLGGSVGDFQGETPPYYYGTHYSCAMIVASMLVRMEPFTQHFLRLQGGHFDLADRMFHSIKDAWLSASERNIADVKELTPEFFYLPELLTNHNNFDLGVKQNGVELGDVILPPWAKGDPREFIRMHREALECDFVSMHLHEWIDLIFGYKQQGKEAAEAHNVFHHLFYEGNVDIYSIDDPLKKNATIGFINNFGQIPKQLFKRPHPQKKVSNKIGDSSGNVIPINRLFFHNLDTLRPSLQPLKELKGPVGQIIPLDRILLAVEQNKVLIPPVYNRFLAFGYADLSLRIGNYDSDKATTVFEGTQSGQIQCAACPNTRTVITGGASTVVHVWQLETRKERTKQLYLKQALYGHNDAVTCLAVSTAYNIIVSGSKDQTCLIWDLNRLMFVRQLRDLGAPVSAVAINNLTGDIATCAGAFLYLWSINGDLVASVNTSTGRDQRILCCAMSELVEWDPLNVIMTGSSEGVVRMWSVEYVQVPDVSSSKRSSTTNIPQAVEPLASKIKDEDCTSESQSEDSQSFNSALIDENEVSTPTGNSIDKAMSDSSPDEPGGDSGGEPDYGTLKANRHSKVGPEEEAGDSLLHGPRPTPPSSLPVEGSYAAVDNRRGPGITLTQPPGEGPTMATPDTLDSCSDKTSFTTVDDMSDIINGNQGEDTDSVSSRQLGNQNLKVENGVSPPSPMQRGEYVILSESDFEKYDEECRDRMSASHRNKLKPGFKWQRQLVFRSKLTMHTAFERKDNMQPAAVTALAISRDHMKVYVGDERGRVFSWSVGDPQGKLMTDHWVKDESSDSCSSCSTKFTFSERRHHCRNCGKLFCSKCSRFESAIPRLHITKAVRVCQGCYTALRLPRETDAIYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZV3</accession>
    <name>A0A8B7XZV3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mucin-5AC-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110976643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tectonic family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085792.1">
        <property type="nucleotide sequence ID" value="XM_022230100.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976643"/>
    <dbReference type="KEGG" id="aplc:110976643"/>
    <dbReference type="OMA" id="FNCCCDE"/>
    <dbReference type="OrthoDB" id="9282501at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040354">
        <property type="entry name" value="TCTN1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011677">
        <property type="entry name" value="TCTN1-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057724">
        <property type="entry name" value="TCTN1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611">
        <property type="entry name" value="TECTONIC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611:SF6">
        <property type="entry name" value="TECTONIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25752">
        <property type="entry name" value="DUF1619_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07773">
        <property type="entry name" value="TCTN_DUF1619"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034451332" evidence="7">
        <location>
            <begin position="23"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1295"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3 N-terminal" evidence="9">
        <location>
            <begin position="469"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="8">
        <location>
            <begin position="611"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="812"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="900"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="826"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022085792.1"/>
        </source>
    </evidence>
    <sequence length="1321" mass="141867" checksum="70FC3606BD859710" modified="2022-01-19" version="1">MFLLTILRHVVLVLLLVENSKSQEIQGRVNLGLDPSSPVPESFLFNLNVGSGTLPLFFDLYNVTNGSSVEGGPFDEDVTVTCNTITAFTAGDSVIQFTNTGTIPLRNGDTTGTVSFDITTQGRRIEVQCSGETAPSPPGTTAYFNPDTSAGRTGFVTIKKDPVASLCSDRILVPNADGITTGQVTLHLSEPVESSNVTGKCEVTGVPPDNPTNWLAFENVRIFIGEDSAVVRYRITGRGGILRVQCSAESDDGVQYQTDLSKTEEALFDFESGSVQILPATSKVTGDMFAPVLALSEPLRTGEADVTFFCRLTPLNTTDEAQDIIDGEPCVAPVDTVPGTTDSPIVITDQIDVVTKTPNTASVGTATPIPTTPAITTQLPSTFLPTNEPTPVNDTATWDLARSQIVFQEGDVAQSLEIRLRNARFGFRGGLLVRCCATAELNTSPKYTGLSSSAIATVEVAAARSINWTSATDSQKETTFTNPAYTEVAPCPCDLTANSCDVNCCCDQLCTEDDLTAFTCITGIPGGNFTKQYAYNCSNRDIYRPDWFPFLCVETDNSPHLGLYFTARSGVRNAAAYNNLKATILAGQTPTSFEDEGQRSLDFTRSDAGGGGYKFGFPVETLFNNNARGFLAVPEVDPNGGCSWLSPIQFQVDTSSRCDVDPQQSLCVESSVLNPRAFILSTNTGYPPCREAPGILTTYGGNKLTPITVRYHCTEDITPYLVPSTELDQLFSPTGESFFPSSDDSGDGSLPLPNRCPWDDGYTLPPIPEYDPATYLCTSAVLDVRYELFWRSNQIVQLDAVVILGSVPLSPQNSMTSGEKEVPAFVSPPPTEPPTEPPTEPPTEPPTEPLTTSVEMVVTVNVTDELITPYANLTDLTSVNASHTLASTLQPATLSEMTAGQTTEVATTQGQTTAAVTTDGPTTADSQMTTGGQTTTPAPTTQSVATTDSGVVGTLPMVTTDSPGGSISQEPNTPLPFTQRFTVKFTHLPTILTDPAPVDPPTVPAQDTRSGNPGYITGKTVLSGLAIVDPLLECNATGECAPVEPAQPGEFVQINDTDANRLRVWVPGPGSLCSQSSLADVTFGEDHFSGCILRLGWSRFSNCSTLREVMLSEFMSMVAADRIGRVGDADIRNEENWAQVFKAGEFAIPTELPPTTEAMTTGEMTTAEPTNETMSSPLELLQGLCYDVPTGVNIEILYANAGEYGSVIQHEILAAYVTYTKSTVKLQCTGANGFVCNLEQTSNETTDWVQSFPVTSTVTFTLTEFQRPLRCDYDQCEEELLFPLSLRFQGDSRTYTVGVAVFVIFLTIVYMVVTKPWSFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y114</accession>
    <name>A0A8B7Y114_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clathrin heavy chain 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110976870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086217.1">
        <property type="nucleotide sequence ID" value="XM_022230525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y114"/>
    <dbReference type="GeneID" id="110976870"/>
    <dbReference type="KEGG" id="aplc:110976870"/>
    <dbReference type="OMA" id="YGYLYLC"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022086217.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42589" checksum="8E78AE9891E81856" modified="2022-01-19" version="1">MDERTESPIISVQHIFQLSHYGVKQEHVTFPRVTMSSHRWICCRHISRKRKKVDCITAINLTRKTPRSLTWPCVADSAMMNPRKPWLALKVGRHFQVFNIVAEKQLHRCTTKDDVQYWTWISDDIISMVGSKAVYHWDLSPPADLGPQKIFIRHGRLSFCQIIGYKADPTQRWLALVGLFREFDNESDNLSYVSGLTQIYSVDNKYSQPIDAQAVSFGMYRRSENILPSSFLCLANRSPGQQGKLHVIELGPHKPGNTALISCTEQLFFDEGDSHDFPVSIQICSNYGLVYVLTKHGQIKVCDIETGTHLSSASVSPLTLFTGAPDCEGKRVLTVDRSGKFSAVGVRERALIDYTRTELKRPAIARRLEKSMFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1F3</accession>
    <name>A0A8B7Y1F3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein unc-13 homolog B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110977314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086993.1">
        <property type="nucleotide sequence ID" value="XM_022231301.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977314"/>
    <dbReference type="KEGG" id="aplc:110977314"/>
    <dbReference type="OrthoDB" id="5831756at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098831">
        <property type="term" value="C:presynaptic active zone cytoplasmic component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019992">
        <property type="term" value="F:diacylglycerol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017075">
        <property type="term" value="F:syntaxin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061789">
        <property type="term" value="P:dense core granule priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099525">
        <property type="term" value="P:presynaptic dense core vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016081">
        <property type="term" value="P:synaptic vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08394">
        <property type="entry name" value="C2A_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04027">
        <property type="entry name" value="C2B_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08395">
        <property type="entry name" value="C2C_Munc13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000002">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000014">
        <property type="entry name" value="protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000031">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000001">
        <property type="entry name" value="Protein unc-13 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1100:FF:000002">
        <property type="entry name" value="Unc-13, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010439">
        <property type="entry name" value="MUN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027080">
        <property type="entry name" value="Unc-13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037302">
        <property type="entry name" value="Unc-13_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10480:SF12">
        <property type="entry name" value="UNC-13, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06292">
        <property type="entry name" value="MUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01145">
        <property type="entry name" value="DUF1041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="8">
        <location>
            <begin position="586"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="769"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="MHD1" evidence="9">
        <location>
            <begin position="1204"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="10">
        <location>
            <begin position="1460"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1620"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022086993.1"/>
        </source>
    </evidence>
    <sequence length="1792" mass="203934" checksum="2A825A74F85105DB" modified="2022-01-19" version="1">MSLLCVCVKKAVLDGPADKFNSYVTLKLQNVKSTTVAVKGSWPSWEQDFMFETNRLDSGLVVELWTKGLIWDTLLGTSWIPLCSIEHSNQEGDGDWYSLDREVEVKNRQVNGTKIPTGHKVLIDVRFEPPFASGQDKELQEQESAVLERKIRLLQDMMQGGQPADQQAQLPNQAVPHSQYLSEDSDYTSDVNVPIAGGLSPHLHSQYPDHQYQDHLPDHLDHRHDRLNHHDDPRLDRSQDRLDHLNHRHHHHHHHQDPYDSEDLHHRPHQHHRHQADDEPLDGSPLHAEEDYPDYELDYDREMEAYYGEEYSEDDHVRYAEEDLGDYVEDDQGSYSEPGLEDGRAPYPDDYYSDEYDPHYREHSFDEYSRDEFEQGESFDMAQSDGESLTSSGVGQRGPHPEYMYAQDSLSGHGSRPSLGTESLVSSQMSSPRMSRDNLHEDDPSLDVVPRREEAGGEADYESHITPAKARWLSAFHRVRQQMEEERSAYLEESANDLSGRGLWSSIANGGLYLDINSMPEILPRRKSIPLEIGVKSFCWSLAAIKRQSGPSTLVTRQSLNDEELKSHVYKKCLQALIYPISSTTPHNFEVWTATTPTYCYECEGLLWGIARQGVRCAECGVKCHEKCKDLLNADCLQLFMTKNSREATGIVHNFMIRLRAIPAMLFGWNLCNSDNTDTVSEADQVREEDSFEEEDFVEINTSSLERIVADQPQEGAAEKSSKHGAEDKTQNIIMAMRDRMKIRERNKPEIFDLIQEVFNIPKQQHAGHMKAVKQSVLDGTSKWSAKLAITVVSAQGLIAKDKTGTSDPYVTVQVGKVKKRTRTVQQNLNPEWNEKFFFECHNSSDRIKVRVWDEDDDLKSKLMQKLTRESDDFLGQTIIEVRTLSGEMDVWYNLEKRTDKSAVSGAIRLHISVEIKGEEKSVAPYHVQYTCLHENLFHYLSEREGGQVKLPAARGDDAWKVYFEETPQEIVDEFAMRYGIESIYQAMTHFSCLSSKYMCSGVPAVMSTLLANINAFYAHTTASTAVSASDRFAASNFGKDKFVKLLDQLHNSLRIDLSAYRNNFPANSPEKLADLKSMVDLLTSITFFRMKVQELASPPRAATVVKDCVIACLKSTYEYIYENCFDLYQREFQPDPSDRPSEADAANGPSAKSLDFWTKLISLIVSVIEEDKTTYTSVLNQFPNELNVGQLSASTMWSLFAHQDLKYALEEHEQQRLCTSAEYMNLHFKVKWMYNKYIETVPPYKDSVPAYPAWFEPFVMQWLTENEELSMEFLHGALDRDEKEGFQKSSEHARFSCSVVDVFTQLNQRFNIIKKLECPNLEIVNRYMTRFSQTVNKVLLAYADVVHEKFAKYCCADKISLQACILMNNIQQLRVQLEKVFESMGGESLDPVAADILKKLQGSLNEVLDTLSHIFSKSLEPRLQESIQQLSTLLSEVKGAGNVALSQPSQKANVQAEADNVLRPLMDVLYSNLTELAQNCEKAVLKRLLKEMWRIVVSTVEKVVVLPPMNDASMSSILATLNPALAKLQQVHGATKEGSREENKNLTPKQCAVLDMALDQIKQYFHASGNGLKKAFLEKSGELQSLRYALSLYTQTTDMLIKTFVQSQTSQDQQSATKSVGEVSIQVDLFTHPGTGEHKVTVKVVAANDLKWQTTSMFRPFVEVYMIGPHLSDKRRKHSTKSKGNNWAPKYNETFQFILGNEDEPDAYELHICVKDYCFAREDRLIGIAVMQLRDIVECGSCACWCALGRWLHMDDTGGTILRILSQRTNDEVAREFVRLKSERRSEGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y378</accession>
    <name>A0A8B7Y378_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110977295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the COA3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086977.1">
        <property type="nucleotide sequence ID" value="XM_022231285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y378"/>
    <dbReference type="GeneID" id="110977295"/>
    <dbReference type="KEGG" id="aplc:110977295"/>
    <dbReference type="OMA" id="SRAHMES"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="9">
        <location>
            <begin position="48"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022086977.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11163" checksum="F25D0485626BC599" modified="2022-01-19" version="1">MATSSSGSDPQQPPETMRRVDLKRDEISQKDREYMARMSRAHMESVQKLSRAKYIRRNVFVALCLGAGVLGVYGYSIYAVSQEAFLEDFEDPNKPKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6L5</accession>
    <name>A0A8B7Y6L5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RING-box protein 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="16">2.3.2.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">RING finger protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Sensitive to apoptosis gene protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC110977960</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Catalytic component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes, also named CRL5 complexes) composed of CUL5, Elongin BC (ELOB and ELOC), RNF7/RBX2 and a variable SOCS box domain-containing protein as substrate-specific recognition component. Also interacts (with lower preference) with CUL1, CUL2, CUL3, CUL4A and CUL4B; additional evidence is however required to confirm this result in vivo. Interacts with UBE2F. Interacts with CSNK2B, the interaction is not affected by phosphorylation by CK2. May also interact with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="2.3.2.32" evidence="16"/>
    <dbReference type="RefSeq" id="XP_022088202.1">
        <property type="nucleotide sequence ID" value="XM_022232510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6L5"/>
    <dbReference type="GeneID" id="110977960"/>
    <dbReference type="KEGG" id="aplc:110977960"/>
    <dbReference type="CTD" id="9616"/>
    <dbReference type="OMA" id="RQNNRCP"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031466">
        <property type="term" value="C:Cul5-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061663">
        <property type="term" value="F:NEDD8 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16466">
        <property type="entry name" value="RING-H2_RBX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000156">
        <property type="entry name" value="RING-box protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022088202.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13617" checksum="081BBF253A3A68A1" modified="2022-01-19" version="1">MSDSEVIMKDETCSTANGKSGPLETTKQETEVKPFTLKKWNIVAMWSWDVDCDTCAICRVQVMDACLRCQTESKQEECVVVWGECNHSFHNCCMSLWVKQNNRCPLCQQEWMVQRIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7W6</accession>
    <name>A0A8B7Y7W6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110978072</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110978072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088435.1">
        <property type="nucleotide sequence ID" value="XM_022232743.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978072"/>
    <dbReference type="KEGG" id="aplc:110978072"/>
    <dbReference type="OMA" id="DESHGWR"/>
    <dbReference type="OrthoDB" id="6067009at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000025">
        <property type="entry name" value="Mannose receptor C-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034734651" evidence="4">
        <location>
            <begin position="18"/>
            <end position="2825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2756"/>
            <end position="2783"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="31"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="172"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="306"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="459"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="606"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="6">
        <location>
            <begin position="726"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="840"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="984"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="1134"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="1285"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="1436"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="1590"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="1734"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="1882"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="2022"/>
            <end position="2145"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="2170"/>
            <end position="2282"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="2308"/>
            <end position="2433"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="2451"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="2604"/>
            <end position="2719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2723"/>
            <end position="2755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2801"/>
            <end position="2825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2733"/>
            <end position="2742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2813"/>
            <end position="2825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022088435.1"/>
        </source>
    </evidence>
    <sequence length="2825" mass="316886" checksum="1B708F6B2A035B4F" modified="2022-01-19" version="1">MQLLIAVFCSLLVAAVAQSGVVKCGGSWQQLNDKCFLAVADSKLKWQDARANCQSRAGADLAIIPDTATSNLLMSMLSGVQSAYWVGLHDLPNEKDFRWVDGETPSDKTFTNWNPGEPNNGGWFWGNEDCVTFLPPSGKWNDLSCNDKEAFICERNSTSIPKCDESHGWRSYNGKCYQFLYNQVTWQTAEDTCAFYPGGHIAYVKSLEDQAFLDNLQLTHGYKYWIGLMDGATDGEYQWSDKSSFDKANSFSKWASGQPKNNWYGQEGDCGSVDTSGLWTISKCTQKMDFVCEIPEGACASGWYLANGNCYQVNSQTLRTWTDAKVYCEAQLAYLTVIKSDVENNAIKSFLSDLHALGINEVYIGASDLETDGTFLWVDGTSATDQYTHWVSGQPPTSPDQKKDCAFINTADSQTAEWRAGDCFALGAYVCQTKAGAKIEPVPTNPITNHCDGPGWNLHKDYCYDIVLTKKTWADADKDCKNVGAELVSVLNDDEQSFMSVRINVVKQRVWMGLNDKASEGTFVWTDNSKFVYNNWANPGNLGTDDCVSMEGQTTSYGLWKVRSCSEKNYYACKKDAIKGPGPSTPPPPTVIYDSRCGMGWEFNKKSGKCYYFQPFEWTNWFGARYSCRLLGGDLMSLVGNDDLAYATSRLKTTGGGETWIGCNDLGREGGWVWSDKKPFVIINWAAGQPDNWQGYTQIGEHCCTFYNNDGTWNDQFCEHGLGYSCNKDDMIFKYFITFSEKRITSTPNKMIVKDAWPKECAQKCLDLPTSTFYCKSFDYERATRTCYLYKVDQATAGGLIPTFDTQHFDYYERDLFANPPPQPTPVPSNKGCPKGWGRYKEFCYYANTNKFDFAGAEAECQKLGAEVTSINDVNVNNFLRAFIFDQNQQENRYWIGLNDRNQEMLYEWSNGEPVLFTNWNAQEPNDANGEDCTELYIDSGFWNDVPCKGYTFNSICRKLVSTGNPPPPQDTTCPSSGNWLHSWRDRCYQVNDFLRSWADAQVACQKEPGAQLVVVEDRMELAYLSGVLGLYEMQDDFFIGFSDSRVAGYYEWLDGTPITYTNWGDGQPDDRQGHCVAISSGKEAGYWADRDCTQKHKFVCEKARTGYPPITPPPAVTPTPPTDTDCATGWVGYGSRCFQIFELKSDDEAVNWDTANRECENMGASLASFHHPDEEAYLTSKLSPKGTRWFWIGLNDQRYEGGYSWSDGTPVEYTNWGAGEPNDYGGWEECVETDFKGGKWNDLGCWNRRNYICSIPKGKMPITTPAPTIPTGDPCPGFPQWVHLNPNCYYFSTNTDGLKDWYEAEEFCHKQNAHLVSIHDSTERNFVTNRLPILAGNYWCGLRANNTHPGNHEWSDGTLLDLKNWQLLQPDTKNGEELCVQMRNDLVIFLKGKWLDTNCGLKARFVCKKNVDGTSPTHPPTSPPTGGCPTGWMKYNNRCYKMMGLGGQQDPKKNWQDAKKECQKTTGANLASIHSTEVQTYLTANMINANGDVWIGMSALASGSKFVWTDSSSVDFVNWAIDQNDQTSFLPGNASDCIRMMYDDSESGKWLDEDCNALHGYLCMMKPDDQYPDNPVTNPCPGKNDYTKFGDVCFKIYVDTKRKFSDAKAQCIADGANLASIMNGYEQAKLQSMMNDKDKPGNLWIGLYDDPNTGVFTWLDGWPVHYDNWGWFDPKGFKYAIMKEQGFLYEAGEWSNIFSDTVKHFAACKYSTATPPPPEPTVPGYCEQDWTAFGSSCYRVGSGIFATGSFGDAVYDCDKNYGGAYVVTIGSKAENSFVKNLAQKTFSVDRVYIGIDRTNNGGWEWVDGSPLVYVNWADDPDSNSGKNCAEMRFDANGKWYHLNCKLNSHYVCEKPKMQVFTTEPPIVFQNCSTGETDWKEMDSYCYYVSKDSRSWHDAEAWCNEKGGYLASIHSDKENQLILALVSLLPSSIFIFPANVNSKWTDGSNPLDYTKGWGTGQPDDQMDSQKCANMVWDGTWADSNCGSLERFACKKKSNSTNPIVKPSPPPQVGNCPDEWYKLETGCYQIKGSQADFKTFADARADCQKQTNGDLPSIHDQGVQSLLTSFIKFYTGNVWIGLRGGTAGWWGYHWVDQSNVDYEHWALNEPSFFYDQTKCTVMVNDPDFPGRWDDVPCDDKHGYICYQPLDPNLPTEPPPISTCVRSGYEAYSDDCFKLNTTHVAFQDALKSCASEVAALATIVDGYAESYLVSMLYANGLQAAWIGFAASNSTGKFVWMDQWPDSYINWGPDQPSDAGNCVVLTDQAVWMNTPCSETYPFFCRSTDIPFVPPTWPPALPGTCPEKWLPYGDNCYLFDTGSDLVSWYEAIVKCSKDYGGSQVLSVHSKGENAFIQRNTKNSFSWYGMWLDLSRNKTASNQYEFIWNDGSPLDFENWKLGEPSQPNFFSRDCASLNSGYGKWETQSCSSNHYFACQKPKVPVPEGGCEKGWFRMNNWCYGAFGRSEPTMQTWPDAEADCNAKGGNLATVYGQNVQSLLEGMIAEERRTFAWIGLSKRSTGFFEWADGTPFHFKQWDKNFPDMSNKDFKCVRMNQDPIYPGMWSNSLCGDEGPHSSARGGYFCQKPADPKLPHDPTGDTCDQKNYYRFDRLCYKAYLGKDQLKSFDDALAQCKQDGASLPSVANGYQEGFMETLLFYYTIKDAWIGLRRGANGKFGWVNNNTHTYRNWDKEPDQGTNNNCVRITNRQKWEGVPCDTKHNFICQMVDTNPPPPGTTAGGTQATLNQTEPPPKPTPGQQRGLGGGAIAGIVIGTLAAVVLLLGLGYFLLKHRQVALKAPDFGNATTTGFDNAVYSPSDDDVRFDGKDSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8A5</accession>
    <name>A0A8B7Y8A5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Uncharacterized protein LOC110977828</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110977828</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087986.1">
        <property type="nucleotide sequence ID" value="XM_022232294.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087987.1">
        <property type="nucleotide sequence ID" value="XM_022232295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8A5"/>
    <dbReference type="GeneID" id="110977828"/>
    <dbReference type="KEGG" id="aplc:110977828"/>
    <dbReference type="OMA" id="CDVCEIN"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="815"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="968"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="975"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022087986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022087987.1"/>
        </source>
    </evidence>
    <sequence length="997" mass="109179" checksum="625F1A5999E3973A" modified="2022-01-19" version="1">MQHTWDLGDVHIEMTSPTASGPSTSNNHVNLKDFLSCTGYSLDRDHDRQAFHADISADSGQQVSGFTKSTVASPRGRSSLTNLMLPKMRRRPFQCKYCTFSCPSATNLSIHMRIHTGEKPYKCGTCSYASARKQNLFRHMSTVHKADRVTMCGPAQATSAYPIALQSSSEERMPVVESVYGGVQDVVLIDGDPVKIVGGDQGNFPTSDTASSSPHISQVYPRQSASSNSQQEDVIEIIPTTSSTPVTEYSTRHYADGSRFIFAGGVAATANSASTKIGAEQTSALDHQFDRTKETPQPQTQTGILNNEVHSVQVQRVVSPDESSVSKSEGPVQPPVYKEPITGALKRKQGRATSHSTLKNILDSPLMLPKRVSTSPTLVSSKSLEPLEKTSTEIKIIQSEEDLDEVLEGRRRMGIHVAPSGARRQQDFTPSPRSLNGGPMAESPFSYSRETPGIVYFPETNTSGGVKEVGAPSADAIPSAQASMVKQRHLSMTKPSLAQKVNEQRGKTDHEDSDDVVMVMDAPRRPFSAGNFSQRHFLQQAVENPSQLNTKSYSSAVNDKKDLPERYSFHNPNTFGRRHRTTTTLDIDREQKLRRNIPLKDSRASLARTALTIQVDLNKLLCCAARKWLKSHLVECDVCEINLPTEREESSFSSGTTRCSRGQSWAQENDDGYLRRARGATSDDQVGGMSSNIFSSRGLDIGAGSANQVHLGDAVATNTRKRQIWDGQDESGMLCSRQKQSCLSSRSEHLNFAKTAVISSSSAPISSTFIRSRTMDQPTECVDEPQESTEYIAFLNAELARGKSTAGRRGPKSKHICDICRKVCRSRAQLLGHRRTHIETSQLYRCAVCRYCTLHYKLLKRHIADKHPTGTKRSAFTECRICKKAIRVTAVASHVRTVHGRGLQVADGRSYNGGNADQVKLSGSLPIGAEDLCSTGAGRGGMQNSPPRDAVAMEADADAVQELAARVDTEEDAVTDGRDSVERDVVQMIKQEPPLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8T0</accession>
    <name>A0A8B7Y8T0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110978724</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022089639.1">
        <property type="nucleotide sequence ID" value="XM_022233947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978724"/>
    <dbReference type="KEGG" id="aplc:110978724"/>
    <dbReference type="OrthoDB" id="5779068at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043588">
        <property type="entry name" value="SSH-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23040">
        <property type="entry name" value="PH_SSH1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034226014" description="protein-serine/threonine phosphatase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="13">
        <location>
            <begin position="277"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="336"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="397"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="527"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="659"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="889"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1244"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1341"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="745"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="809"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="915"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1020"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1077"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1135"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1159"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1176"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1201"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1276"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1352"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1362"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1380"/>
            <end position="1392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
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            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022089639.1"/>
        </source>
    </evidence>
    <sequence length="1409" mass="155753" checksum="69C35DA2F88EF76E" modified="2022-01-19" version="1">MSCTLHCRLGLLWDSVSWSGQILLAGILESPPSTCSSFDWWMAVELVIERDIPPLPDECDSEERVKKQCESFFAVKGAALVLPRSNESRPIKKNPIVGELSDHIQSMFLLLRHDDRMTLAVRLESMYEERIRYIILVSCNGVQDTEESVILGMDIMSNTATIGLVLPIWCETTIQLNGDGGFNLCSKSRTHTFKPVSVQALWSAMQAIHSAISSAQTYNYFPGGLNLTWISYYESRVNSSPSRIKEWDLMPELEVTKPHAFTPTYTEDGHYHPSDRELTEQLIFLKIKDIMASADLDNITSREVRLKMEDDLGKSLNEYRHYLDEQLITYMRQMDSATLIFDHIYLGSEWNASHLEELEANGVGYILNVTMEIDNFYPNRFIYHNVRLYDIESSELLKYWDETYKFLSKAKEKGSKALVHCKMGISRSAATVIAYAMKEYNWPLEKARSFVARKRKCVNPNTGFLQQLQVYEGMLDASRQRHNKLWRSKSESSLANSAECSQETIESASSTEDIADRTSKVSEFTHQGNTAGLSLSLGPQTGHARRRSWSPKDSVADVHFPSNVQSLSGHQKPDHLGTSPADVDFMVLDDDCQDIQIIVPESLTPTSPTLTVPTEPVVLGQIEDREPTAPLPGVGDIETGLADSQLESLHLDRVSTEELLSVGESPSGFKEGIPEMTSTPSQPEQAMETEVSPPGGIPEISSESGLNTNNNSATGYSSSQIDDIPPVEGTVKQRVTSFENNKLAPDAEKVEVKSEEESASTVDGLFLEPEIPVNSGTVQKQKQDIEERLRAESAEKGSPPLTRSEKFSQETATSPTVDSTTCESLDTPASNQPKLAEPQDCGKPETVDCDLSSPKSPAISLLQESPTNASPTLQALEKGRVKKITEQLLSQKTPVTEAEEDEEALSLAEKRRSLTFESGSPPQDSPTKLTLSPSKSSPDTRSTEVIETTGLAPKGSTSPDDQSVKDSGSQESLSTEESVHSGSPLKEAFIKTFFGEEIPLEPGTVKRQTIDFEQLSSQSRTEELETKKEAVIKKDTFETPPEMPEKTKAEEMVVIIRDSSSNGKRKFEEVGSQNKHARVDQKEQSTKDEAVGMEPELKMEEENQKEAEINSAYPEEGISSWKVGDVRKHTKQFEGLSSSVDAADQSTKPASPIMTEDTAEARVTTEESTSLREMTEQTSTSSSSGSSEADETVTEVPQVEEDVHVDHGSEVGKEEKLNVESIGERIAKLGLNLRRVNSIARMSNEKGSPVVMRRSDPSRPVSIRSMRPYSDTGTRSLESSPESQSQLAKGELTMEETQERRKSAYARLVTPRQDTVPLKFYLEEPLSVEIRSLDSAKEVGKMTMTGTSDGIPVKPSSSVKPDSGEKANKATSRDCQSPKASRKKQQHGKTHPLSKLSPTPAKHPSSGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9C4</accession>
    <name>A0A8B7Y9C4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Centrosomal protein of 57 kDa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110978854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the translokin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089843.1">
        <property type="nucleotide sequence ID" value="XM_022234151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9C4"/>
    <dbReference type="GeneID" id="110978854"/>
    <dbReference type="KEGG" id="aplc:110978854"/>
    <dbReference type="CTD" id="9702"/>
    <dbReference type="OMA" id="YMKQMIA"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025913">
        <property type="entry name" value="Cep57_CLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14073">
        <property type="entry name" value="Cep57_CLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cep57 centrosome localisation" evidence="10">
        <location>
            <begin position="47"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="9">
        <location>
            <begin position="327"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022089843.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="54311" checksum="AD449DCFB7771BBB" modified="2022-01-19" version="1">MTSAGVAPESISSYQDYPSNLSLISDRYPVMRTPKRVNSAAESNNRAVISALLGLQEKIRRLEEERTEAEGNLKSLATETAHYRDLMKRQRAVKQTSDMPGSKETQELQGQLASAESRSQLLEKQLEYMRNMVRSAEQARDSALRQQELQSMQLTEKASEQVRVEEEKIRELEREQVKLKATQALAESKLQDLENKVKEEKHHREMQHSKEAHLQYWKVSDKALQGTSNKVKKPKKKKGPSTSIPASSKVHVPSHSKRPCSSRHLRLKMENVPFVAGKAVTPSHNVNVNMQSLIALMKTHHSAWCGNASVKKQPNRLKAMSKKSQALSSGTSSDSDLSDLLLGLQDEFGQLALEHQELTKQIQQTAELQLQDQLEQELAQIFSRMEAKGEQINKLKKHKQKIAKKVPNYSAKPKLEGRGRRSPSVPSRDGEVKVITTVTTKGSGIKTKSFKVITPDTKSNQRVLHNMKTLQTSLCKDDVTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA88</accession>
    <name>A0A8B7YA88_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific protein-tyrosine kinase</fullName>
            <ecNumber evidence="1">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC110979028</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022090164.1">
        <property type="nucleotide sequence ID" value="XM_022234472.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090165.1">
        <property type="nucleotide sequence ID" value="XM_022234473.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979028"/>
    <dbReference type="KEGG" id="aplc:110979028"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000521">
        <property type="entry name" value="Tyrosine-protein kinase pr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055175">
        <property type="entry name" value="ACK/TNK-like_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22931">
        <property type="entry name" value="SAM_TNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="105"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="376"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="697"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1453"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1494"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1532"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1598"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1768"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="716"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="908"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="929"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1041"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1085"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1144"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1193"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1296"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1504"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1598"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1610"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1622"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1648"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1781"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022090164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022090165.1"/>
        </source>
    </evidence>
    <sequence length="1881" mass="204349" checksum="144D0F812A462B8E" modified="2022-01-19" version="1">MPYEGTLYEFLSEVGLQQYHQDFVSKLGVTAIDHLAYVQTDDVLQLGMTQPEWRRLRASMKKVKKGKFKPGKNAKVSKTKPTIVRVPSQTSSPSGGHIIPASAINILDRELGRGEFGKVMQGIWTDKDGQKIQVAVKCLSPEKLSADKAQDFVKEAAIMYSLNHDNLVKLFGVVLDVDTSLMLVTEFAALRSLLENIKQPTLRPSFPITLLLEFAGQIADAMRYLHLSNIIHRDLATRNILLFVDDDGTKKVKISDFGLSRRLILGENYRSEMRPNLKLPLAWMPVEALTKLTFTKASDVWSFGVTMWEMFTYGRQPWATYTGEEILKAIDKPALQRLERPDACPVKIYDILLKCWKHEPEKRPSFAEICEELPKAKPVQVRAITHYKPTKDGELAYRADDIITVLDANENSGIWTGILASGKIGTFLRCNTTLLGSTSTAGGSRLRRWKSGFRSDKRDARKSWHGRLTTDAIGTPMGARHIFHVGPDGTVQGDATFGGDYRTLPSESKIRQPWSSSSSVSSASSASTTRSPPRSPYRTNPPDQKVPVGASSSATLPPSHSVQSLPPRSSLLKANGELTSSTPELASAGAPLHADQDELDSDLSELPAVLPKEREVLASAAANSRIAEEPKISPLTETTMEAGATIEAGATASFSAEMERPPSPDSFSLSLNLEMGSLLDEFMCEWDDRRHTVEIQDGKMMQRVPKEDKNKNWEVGGTNSDSGSLSSSSTTGNTPRPGSLHLSSSSGSEGGKMSRGGVVSVLRSSSKKKAAAGGAVGTDGSGEESMTPLHNMIIKDSPSNPAKTYRRVPASTGTSPAAVATGEGATGGDRDSPDDSCGRSEGSEVRLRVNLNRANSVQDKKDEMNFVRLSTSPPSKAENDYIDISSLAKSSPNSPALDGVSSRQPFVSSMSTSSSSSSERTCSPPSLSLSQKVSSGDFSSPNEYEELSDATSADPEDVLHPMPTKPNFVSQYPPAKEVGRSKSMRVTSSGPAVEDLAKRRGQFGRSRSLKETTATARAEEVYAKLIGGRISGSPTLPPRASPAVSSPPRAVGSPGKSTNPFLDASSSPTASPSRRHVGVLERMSSVDSSDGSNKDGWQNSTSDRDSRELQFGPGDPLDEGVEVTGDKMEVNIGVKALRSRFDAPSPPPRQAPQSPSPKKPPPPKVPPRGPRSQKPPQPSVVKSTANIVLHSPTGITHSPKGLNNNYSPEGDSKVFGSPDSQSSIDVKLSPKTLQSLEKNMPRRVRRSVGEARIKRRGSSDVSDSDNEPSLVKHHSADISLRTVEGDSSSEETAGKFVGGESGVGFGVSLARPLPDLPEDQTNRNTAKFPRPLPPPRVPSSSSHPQYRQSMPARSPGFASDQATSRANSEVERVDLADFAPRPVPLPSPSNAPNAGNDSDGEADERYMPPPTQRQINGALNFGAQGVRNPMTRGHTIDVIIPNQHSTNPFLQAQTPLRPPLLTSQSVDSGRGTADGMEDLVRASPEDIRRIIQQESTLKTLASQSDEDSYDDDDDDDDSRDYVVCRFNNDDLSDLPSRLPPAPPIPVSQCKPSKPKELVRETEYEIMNPQRDSVFLSEVEQVSVGVPVQQNIPLAERELPPLPALKDDNRSSSLTRSRSAHSFTWSSRIPSSQQLRERRGTLASTSRSETLKEIDERQGTRSLDRLERKSRSSDDIPEEEPGLKEVESLTDVLARTYRSPPVSVGSSNYIFPRPQNNFLSQRIQAPMVHPPIPKDPPPPSVINNYHIPRPLPACSSEDYIDMTNTRRRQSNLAGFGSGKGVGSEKTEGVDAKPPDGGPQKALDIQSVRKELPDMISLEECTQVLRDNLWNVPLTIKILKIRYLTRTFLMDDGTCRQALEEANWDLGIASAIIGQSPESSISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBU6</accession>
    <name>A0A8B7YBU6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">(Mt)TrpRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110978863</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022089855.1">
        <property type="nucleotide sequence ID" value="XM_022234163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBU6"/>
    <dbReference type="GeneID" id="110978863"/>
    <dbReference type="KEGG" id="aplc:110978863"/>
    <dbReference type="CTD" id="10352"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022089855.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42796" checksum="C9266DDB053C2BDA" modified="2022-01-19" version="1">MQTSRLELLMCMPCGKMRRSLLRRFKSYQSMLCALSKRAYCGTASMKCVNMSKRRIFSAIQPTGIPHLGNYFGALQNWVQLQNDPDNKLIFSIVDLHSITLPQEPDVLRQSIRDCVAVLLACGIDPERSILFQQSSVHQHAELAWVLGCKTTLARLGQFPQWKSKSGGDKKKECVGLYTYPVLQSADILLYKTTHVPVGEDQYPHLELAQDLARIFNNNFGSFFSIPEAIAGEISKVKSLRNPSVKMSKSEPDRRGRIELTDSYEEIQEKFRKAVTDFTGAVTFDPDNRPGVSNLVAIHAAVQESSLEEICEQNMGVETGEYKLILAEAVNAKLAPIREKIFELRRNPEYIDSILRKGAERASEVADKTFSEVKKRVGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCR8</accession>
    <name>A0A8B7YCR8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110978636 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110978636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089461.1">
        <property type="nucleotide sequence ID" value="XM_022233769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCR8"/>
    <dbReference type="GeneID" id="110978636"/>
    <dbReference type="KEGG" id="aplc:110978636"/>
    <dbReference type="OrthoDB" id="6107927at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034386789" evidence="3">
        <location>
            <begin position="25"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="29"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022089461.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="59106" checksum="7907AB934FEFCA8F" modified="2022-01-19" version="1">MELSSSKLTACVITVLQLLRVVTSNRILLSCSFETTCGLSYTAKSQFYWSRVSGATPNQYTGPSNDHTFGNSYGKYIYAPSSRNEYDFGRRSTLYSPAYRLTSGKGRLEFYYHMWDGLRPDDMGSLSVYVCGDDSPLWIRRQNQDNRWRWTGLLEFSCDQQFRVFFVASRGKYQSDIAIDDLIITDIFDDPTTPIITTVPPTTTPTITTAPATTTPSIIAPAQRTTPNPPPSTKPTTVASTAVTPTTVAETPQPQSTPGPTATPSTVSAAGTPASTGAPRTAPSATDVQTEGPPTTVANKETSSSIRKADIQTSSASNNFSTISVSVGPNLQSGSSSPSFIGPIVVVCVALLFVGLTLCLAMKRKKSRCKNTTLSNTDKEVKYTVENPSYGGVNSIAVTGDSRQPNSYSYQELMRSQSGCEDGEREGKYNTVDGGDAGLMGWQGHQEDREEAGAPKRRGESVLYAAIPDQGGANEYSYAYPNPGGSRGGLSSAGRGVGPRMATPGRAQWDLEEREYAAVSDPVNKPGHDDGGAAGAYGMVDNQFYIPFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDE1</accession>
    <name>A0A8B7YDE1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Photoreceptor-specific nuclear receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Nuclear receptor subfamily 2 group E member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Retina-specific nuclear receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110979610</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091274.1">
        <property type="nucleotide sequence ID" value="XM_022235582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDE1"/>
    <dbReference type="GeneID" id="110979610"/>
    <dbReference type="KEGG" id="aplc:110979610"/>
    <dbReference type="CTD" id="10002"/>
    <dbReference type="OrthoDB" id="5774777at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06970">
        <property type="entry name" value="NR_DBD_PNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06950">
        <property type="entry name" value="NR_LBD_Tlx_PNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000022">
        <property type="entry name" value="Nuclear receptor subfamily 2 group E member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000028">
        <property type="entry name" value="Nuclear receptor subfamily 2, group E, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="18">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="19">
        <location>
            <begin position="205"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022091274.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48002" checksum="56906A6D161B61EB" modified="2022-01-19" version="1">MDMEVVRMGQDHGSDMSESAHKRMTSGLTCRVCGDISSGKHYGIYACNGCSGFFKRSVRRKLIYRCQAGTGMCVVDKAHRNQCQACRLKKCLETGMNKDAVQNERQPRNTAQIRLDCVPSVTAVDHPDFDGSPGSIIRGEQASSTVPTMHRSVTPTINHRFMASLMTAETCAKLEPEDERCRQSPYVALQDNGEVDVTGGMDIESDERLRQGAVGRSQHHDNTARDVAIYPGTQENIYESSARLLFMAVKWAKNLPSFANLPFRDQVILIEEAWSELFVLCAIQWSMPLDSCPLLSLSEHAHEVGAASPDTKAVAMLSDIRVLREVMARFKSFAVDAAEFACMKAIVLFKPDARGLKDPIQVENLQDQAQVMLGQHVRSQQPTHPSRFGRLLLLLPSLRLVSSDKIERIFFRCTIGNTPMERLLCDMFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEI9</accession>
    <name>A0A8B7YEI9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Meiosis-specific nuclear structural protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110979377</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090815.1">
        <property type="nucleotide sequence ID" value="XM_022235123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEI9"/>
    <dbReference type="GeneID" id="110979377"/>
    <dbReference type="KEGG" id="aplc:110979377"/>
    <dbReference type="CTD" id="55329"/>
    <dbReference type="OMA" id="QIRNQMV"/>
    <dbReference type="OrthoDB" id="197839at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026504">
        <property type="entry name" value="MNS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265:SF0">
        <property type="entry name" value="MEIOSIS-SPECIFIC NUCLEAR STRUCTURAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichohyalin-plectin-homology" evidence="16">
        <location>
            <begin position="113"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022090815.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="61604" checksum="112217D1FF4F726D" modified="2022-01-19" version="1">MAMVRRNLTHAQQERQQTENRRKEEVRQDHVKRLHQEKLFEANMASEERVETKRYIRQMQKEQMEREMLENTARAQQMRTQREQQMQLEEQMARTMEQMKLQEKRDHLIRQQIRENSVELRELERALKAGYMNRERHAQIAEKEAVKYEKTARDADIARMMKEESARAEDEDRRKMEEQYHEKVRYHQELEKQLEEQEKKKQEDYEEFLKEKLMIDEIVRKIHEEDERERELYLMKQRATQQYITEFKAAREDWKQKEKERMEEENRRILEFASMQQMREEERMESKRAQEEAKAAVQQSLSEEIAQKRAAEEEMANIRQQLYLEEQEEAEIQKMQAEIERRLRQRLDLQQSRREELMLKELRKQAEKEEEEEFKKQMLAKFAEDDRIEQMNAQKRRMAQLQHKRAVEKLIEERRAQFAADRQRELASRQEEEMLERLRQEIIEEERQKLLKEHASKLLGYLPKGVIRDEQDLELFDDEFKRRYTERQRDFFEDGGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YG41</accession>
    <name>A0A8B7YG41_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-glucuronosyltransferase 1-7C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110980136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092204.1">
        <property type="nucleotide sequence ID" value="XM_022236512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YG41"/>
    <dbReference type="GeneID" id="110980136"/>
    <dbReference type="KEGG" id="aplc:110980136"/>
    <dbReference type="OMA" id="VIDIRHI"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034547359" evidence="5">
        <location>
            <begin position="24"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092204.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="61936" checksum="A3F9D759B4FC0614" modified="2022-01-19" version="1">MAGEFLGMIILLGVILQPYDVFAGSILMSAGVDQTHYIFSAKIGRELVRRGHHVTFLLSSSYIHRLNGSDADWFDYQVFNSPYTPQDVKKMTDNFAQESLNNTYQSQEGYLKLLGRRLLGLKSEEEKREELKPTKPMSKYLSFECNILLGDEKLMETLKGRNFDLMTFDLINPCMTLVAQKLSLRYVIITAASLTPGLHDRWYDIPTNPALVPLYMSGFTDSMTFWQRFRNAFTWLGMSSFMDRLMLGPYDALKIQHNIRTDLNMRETIRNAEFWLFHTHFAMDYPRAVTPNAIMVGGLSADEPKPLDKELEDFFEGSGKHGIVIFSLGSVVNVMSDEMKAMIAGALARLPQRVLWRFPGEPPRNLGQNTKLVSWLPQNDVLGHPKTKVLIYHGGINGMLEAMYHGVPVVTIPLFGEHFECANRLQTRGMAETINLPELTEDKLHRTVVQVLSNESYAANAKRVSAIMKHNVAPPVEVAGHWVEHALLYGGAYLRSTAGSLTTVQYYMLDVIFVGIVMAVSLFVVTVWVYWLLCCKIDMSDNKMKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YI31</accession>
    <name>A0A8B7YI31_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110980487 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110980487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SYCP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092893.1">
        <property type="nucleotide sequence ID" value="XM_022237201.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980487"/>
    <dbReference type="KEGG" id="aplc:110980487"/>
    <dbReference type="OMA" id="DRPKQGK"/>
    <dbReference type="OrthoDB" id="10256849at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000800">
        <property type="term" value="C:lateral element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140013">
        <property type="term" value="P:meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024835">
        <property type="entry name" value="SYCP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041322">
        <property type="entry name" value="SYCP2_ARLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040560">
        <property type="entry name" value="SYCP2_SLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15607:SF18">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15607">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18581">
        <property type="entry name" value="SYCP2_ARLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18584">
        <property type="entry name" value="SYCP2_SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Synaptonemal complex protein 2 armadillo-repeat-like" evidence="8">
        <location>
            <begin position="16"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Synaptonemal complex protein 2 Spt16M-like" evidence="9">
        <location>
            <begin position="285"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="876"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1208"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1491"/>
            <end position="1539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1562"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1624"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1938"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="627"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="690"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="810"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="884"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="920"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="946"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1042"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1086"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1120"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1304"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1325"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1351"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1381"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1498"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1573"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1626"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1659"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1684"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1723"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1791"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1854"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1864"/>
            <end position="1874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022092893.1"/>
        </source>
    </evidence>
    <sequence length="2047" mass="228026" checksum="EB4D9FCFC683126F" modified="2022-01-19" version="1">MPVKLGTTDRELEYVLMRKAQQQSYFQDIQDFLQEQNTKKQPGPQQCSVEVMKKITVVLQEELAKQQFQDAVVMISAIQFTTRFPDYPAGLPVLLSNGLIDLLAYALEETQKYVSLSDGTEVNLTADSLFEVILETVNDVADFSEHAKRQSVGVFTEKLMQLFVDKNKNFHVRMEAIRTLNLLLEGCLDEVIQVLREYPPSLKRMGLMADLLTTAGDFEMQVACTESLARLVKRSDKASSNLIKDWFSDPHFATAFMEIRDDTFETDCRKFLNSINSSLGSKQSVFSLPCLSAHLGSFKLRCPDDVNLQDFWVDFNTVSRRITLYVADEELQKENEEGGMWETVTIQNEAVEKFRLSERVGRQALFISLNVPASELLGFCPSDDKCAHIVFDAKVDVRCAAVAVFGQDKLRHSKHKTSVSKVSIQVHVDDSSNSPGPWRNIRSADESSDSISIQSAKIYGLGGTDDESSGLRASRSKPIKTDSEARAPTKHKVSVPLSPMWTPTMAKNVATQRFSSTKSVASAESSSSVKPLCKKSDFAQPQTPVTLKSSTKRVKTPLQIVVSDKATDSAAESEISCPSIGKKASISSGVSISSCGTPTGLRLKLQREAMTRQQQTSGLQDAKPGSGSRSDPGPTSSASFQQAGMQPHPSTTRLQNGLPSRIDGHRSDPGSSTCKDGLPQQKRQLRSRVNKHDAPEHQQEPPRRDGGYRREEQVSSGGEEESKRKKPSRKFRLYSDSGGMMTEAEEDSQEASNTDLVIPSTIPTEESPVDVIPDSLPPSGQLQPDEATSNTSRIQNRSNFGRYHPVAHSPSLSTLTEESAQSAKGRSTKTTATIISGSEAPTANASLQRSKMTLQEEVIQEVLSEEGVLSSRVAAGSSCPETCHNSKMDAGKVQERWDARVGPHDKNSNAKDDSEKVGESCEDADVIIIDGDEVLPDVPSGNKKLSKPDQKGDRREDEEEYDQDTDVDKTKAAKNRGKAPDDKSRPLPPSRAFRKVPLQMPDSSQELFTSQMEARPRRGRPTKKAWREGNVKKQPKKQGGKSAKERPPVEEPRLRARSQRAAAKAAEREIRTLSQSFDSCPEANDKPTSGMESSDSSHPIIKKSKGKKTENETEKKTRTSRSLKALTNLSARSSQDSADLSVYDFVEVEVERSSSSDSVVKKPHLRTAGARKRGQLLKSTQEALDISVYDFADSESCQSVSLQPCIKKKPSLPTKAARNIPAKVNALAQHAKSRKHQRVHLEQSDKPLKTSKKLFRNSQELWDTDDDQINVSSRLRSKNKTVKPPPSPEELSDIEQPRDAPQMSFLSRNAQLSPVESSDDQYLDQDVHSFVKSFTNRERKRAAEAVSELMSESRKSRCQTDKRGEKSRRERPRSGRNTYVLDKEQVERPSKKSSTASVEKQRQSSREPISSRKPSWRRKGSSFGVEIVEDESEEVPNREDAVSISSDDDANTDTVSVENFSKVCQSLVNKSGRGLATKQSYRNIPKIYYQSQDSEWQSNDEEHEGAQEEEPGSLAASPEPPRRSSKKRREPDVVSERSWLAEKPMQKVCTYSKTHKKEWVSLTSTINLDTTVKKKPRLNKRKPRKKKDEKPALPRKRKQNPLKSSQEADVDSLDMCLFYYRENHESSSLSDSQLRRSSANKTLLDNSTRSEKTVKSMPRCTSTPWSLHWSSQEEGKEEESSIEVARDDPDRATGDIEEDLYPLTPSVLVEDMQAGGRPDLVTPKSLKISSSISSRGTSSSGKTPKQVTFDSDPNYAEDFTPVIEEDCLKSGPSSRACPTASTLKRKYGDIFNDDDGEDDGAQVDGDTVVSSDGEDADGDVPPCGLVPHSGQGSLRPKKLFKARMTTTSSNSPEVEMEDTEDTSTGDIPSSFQSLGSFPTMQITKMFKTITSTHKQRMLTEQRQARQLTEGAVKTTKREVSKLWSQQHQARSEAQEEFKSRLLAEIVSLEDELGHLKDVQRELQATLEQHCHMTASTLLKHIQRVKSLHSQHETDSGELNRQLGRHLQHGVRQVLHQEMVNMHKLLIQDAQQHELQQMRKGLLNIFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIH8</accession>
    <name>A0A8B7YIH8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110980546</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110980546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093033.1">
        <property type="nucleotide sequence ID" value="XM_022237341.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093034.1">
        <property type="nucleotide sequence ID" value="XM_022237342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIH8"/>
    <dbReference type="GeneID" id="110980546"/>
    <dbReference type="KEGG" id="aplc:110980546"/>
    <dbReference type="OMA" id="ARYMEME"/>
    <dbReference type="OrthoDB" id="276540at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37935">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_14, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37935:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_14, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093034.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46008" checksum="8077AF4847B6E1A3" modified="2022-01-19" version="1">MNTLFSRVFCHHFMQEPIRHTIYMYLKFSSYSQCSFQSSNYPKTSSCVINSAVISPTKFPHYGSVHLSTHPCRLQLHKSASYEVPACLRNISRPATMAPLESMPVLQSCKSVASKRHVISRPHSANDKSNKGAVPHHDTVLLRMQRLENSLRYHGYSTIRIGLVLVVVIGIAVYIFREAIRENVAEEVSQVATRSLEDRLVAERAEEFAKGLLNALLKDEPMHQLASQFVVEVLQRAETKQAMNTLVMDVLKDPNTKAQLTATVKQVIVTALNDEDSQAYIKSVLSTILSDKETRRAVVNLLGYVFREREVKEQTAAFFQEVLKSETVVDQATQLGKQVTNSVISDPVLQEKTGDSLWTALVYSVTPRWFSGSSTPSSSPSAPPDSSHVTQDKIPQTDRVRQDSDEESVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJY1</accession>
    <name>A0A8B7YJY1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110980401</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092730.1">
        <property type="nucleotide sequence ID" value="XM_022237038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJY1"/>
    <dbReference type="GeneID" id="110980401"/>
    <dbReference type="KEGG" id="aplc:110980401"/>
    <dbReference type="OMA" id="LLELHVW"/>
    <dbReference type="OrthoDB" id="10042460at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022092730.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="61470" checksum="2BDF5F39DBBC2951" modified="2022-01-19" version="1">MNSSSEYRPLLNQDPDRHINSRAYTSDSSQSIMLENPVSCSGAGESVTSPLGRKRWPWVIWLLLKIIGLYNYRRAVTRRPCYDCRLAALQSRQRQQISGETGGCGPYPGAAVSRDEDDEKEQVLVCLVDGNMNTVAEQDSPGTLAGDACQVCRSEWWDDRGRYRPYTETDIGVRKWNHRGSAVLSFIFPSVLICLILYDFFFYLRDYWGQKQQLIRLISYSTFLTFNMTSPFLSVVANVRNVMMDHRWMTRRRGFSWYECLGLRYIVKRLQHMGLEAGMAYKPYLAVCVIWPALNGGLRIAIYYLFVVHKSMDVHIQISLATGFVCMLAWGGFCYLMLLMRLSFQKQQRLELAFLWRHKGQVDVCRGRLRLYAEDLGSMCRLVSGWVIVVVAVSTWAFTTQICWDYLVISTGLKFKNADLELQINLLIWSENIMFLVLPLVAVGGFDINKLWVQFVRSVSQMRSEALEDFWDRVLVFCEEQSPTYRVETLTLVFSALGLFLGLHFGDQNVDYWMRGKHNSTLINPVTGNLVPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK18</accession>
    <name>A0A8B7YK18_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amine oxidase</fullName>
            <ecNumber evidence="7">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022093603.1">
        <property type="nucleotide sequence ID" value="XM_022237911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK18"/>
    <dbReference type="GeneID" id="110980873"/>
    <dbReference type="KEGG" id="aplc:110980873"/>
    <dbReference type="OMA" id="EWSHIEP"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022093603.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="25889" checksum="FF5FBE1E79A9B47D" modified="2022-01-19" version="1">MYIDLSNHSNVAQAFWREDGFSGEIVSNGGKPTIEGLSSGPLQLTYDCTTSSGNPAIVGFYANSREWSHIEPQTRKQAVLDSLAEFLGPKARDPLDYCEKDWALESYNGGCPVNIMTPGAMTFHSGLRTPFFRVHWAGTETATHHTGFINGAVQSGMRAADEVLRRLEPHRQADRLLICLDNQRKTHWYGEEVGKWKRRLFIGGAIGVAVVTALTVKRWGLKGTATYILSAFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YL85</accession>
    <name>A0A8B7YL85_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110981099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022094023.1">
        <property type="nucleotide sequence ID" value="XM_022238331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YL85"/>
    <dbReference type="GeneID" id="110981099"/>
    <dbReference type="KEGG" id="aplc:110981099"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF211">
        <property type="entry name" value="PROSTATIC ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034252772" description="acid phosphatase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022094023.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="28151" checksum="399FF55924D0BDAB" modified="2022-01-19" version="1">MYRVLLVFIFLLGRCGFQPFGGLVRGERTRQLVNLLYRHGDRTPINIYPSDPHRADTWPEGLGQLTTLGMEMHYKLGQWLRNRYIDSEFLNATYNRDSVHVRSTDSDRTLMSAESDLAGFYPPQGSQIWKPGFDWMPIPVHTIPLDEDYLLKTNGPPCPVYDELKAKTKYEKKYKDLEAQYKARHTLYMYMYITYQNSLKCFIDVLIATPTPYQPFLQMLLTSLGENLYNGFCPYPTYILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLL5</accession>
    <name>A0A8B7YLL5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NXPE family member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094158.1">
        <property type="nucleotide sequence ID" value="XM_022238466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLL5"/>
    <dbReference type="GeneID" id="110981156"/>
    <dbReference type="KEGG" id="aplc:110981156"/>
    <dbReference type="OMA" id="TESTICW"/>
    <dbReference type="OrthoDB" id="5950832at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="2">
        <location>
            <begin position="345"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094158.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="65899" checksum="984D316291F61DED" modified="2022-01-19" version="1">MAKNMSSIDVKDLNNSADVWRRKPSMRGLIMWLVLVGMAYLIVTYFTTGHVKLPHPLPSQRKFSARMLGSVQNIISNYLAQLPNVTPATLSNPTVAGNSFFYIQYPKASYNVCDQLALYIEARDNTNKTKTSGGDFLWPYLQTASLRASTPADEVIDHGNGSYTALFTLHWAGEVEPFVWFVLSSEQSYSVRKIRDQIPYRFAYDAIFTDDQTIEVTPCHITKDIYVDKAAKGLSFAPKAEVCDFSDPRIGSTWYCLKPKTLSCSNRSQHRGNIERGNSYLQQALQDEKVSLAKPEMLKNTGQVRTVKVMSEVSDSACLDLPPCDSGLPPKRANHAAGYYFRDLWKSKVCLARELQLKETIECLRNKHLFFIGDSTIRQWFVYLVSHLGKAMKEYKIWTKEGVIQMHRHAFDKVHNITLDFRFHYYPILGNWLNTTTIYSAIDLIDSLPGGRDTVLGFTMWAHFTYTNLTYYLSRLEPIRDAMIRLQERSAGKATVIIKSANTGILPYTPEITELLSYDLDQTMRVFFRDVPDVIIIDVWDMTLSHGGRYNVHPSKLVIREEIKMVLNFVCSNTTTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YM20</accession>
    <name>A0A8B7YM20_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycine-rich cell wall structural protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094313.1">
        <property type="nucleotide sequence ID" value="XM_022238621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YM20"/>
    <dbReference type="GeneID" id="110981228"/>
    <dbReference type="KEGG" id="aplc:110981228"/>
    <dbReference type="OMA" id="DDTHQDE"/>
    <dbReference type="OrthoDB" id="10584286at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094313.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="15240" checksum="E6E15DEDA9ECFBF9" modified="2022-01-19" version="1">MVQLGVSAEGQKPDPVKKPPESCEVPIPPKTQPPVAVRKGRCSKKVVCVSVITVLILLAVGATLLGVFLSRHHKSWKDCFGWGDWDNGDGSHGDWSHGGGSHGHGGGHHGGHGGHGDGDGPGGHGGEDDDGGRGYPGNEGDHFPDGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMG4</accession>
    <name>A0A8B7YMG4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110981292</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094453.1">
        <property type="nucleotide sequence ID" value="XM_022238761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMG4"/>
    <dbReference type="GeneID" id="110981292"/>
    <dbReference type="KEGG" id="aplc:110981292"/>
    <dbReference type="OMA" id="VENMKIF"/>
    <dbReference type="OrthoDB" id="10015025at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022094453.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="27350" checksum="E37029DC6D3F5F24" modified="2022-01-19" version="1">MTSQLVQSYIDKENTTSHGTTNGKARFGSVAGRQGIPGKTFSVGSSAIATPRRALGNLSNDATRLASGLGNSQKKPIKSVGGSGVFRKPLGSLSKTPGLSMKNPSSATPSSQMLASKHKIKPQVMAVSSNLVRPTDSYPEIETMHIYQDKEPEFESLPPEDCLSVYLDRLSSLRVPPMPHPQTKAPQGCPTDFSHLQLEANDRFLESGSTDTPVSCFDVDTPLSLDSCIDLPPLDSVDFMDINNILLWDQQGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNK2</accession>
    <name>A0A8B7YNK2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adhesion G-protein coupled receptor G4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110981540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094853.1">
        <property type="nucleotide sequence ID" value="XM_022239161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNK2"/>
    <dbReference type="GeneID" id="110981540"/>
    <dbReference type="KEGG" id="aplc:110981540"/>
    <dbReference type="OrthoDB" id="5961629at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034193877" evidence="8">
        <location>
            <begin position="30"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="973"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1015"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1086"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1133"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="10">
        <location>
            <begin position="532"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="9">
        <location>
            <begin position="742"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="918"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022094853.1"/>
        </source>
    </evidence>
    <sequence length="1234" mass="134195" checksum="D637A4BEADA77277" modified="2022-01-19" version="1">MESRPRNLVHRGAVVTSLLLMTVFVGTDSQDVCQSGTGPGGSGTRCNCQQVEPDAAFNIDCTGRSLTDIPTIPVNTAVLDLTNNNIQLIREQHFRRLDTLQKLILTGNPLECGCNLTDFKSWIINLESVSAQIVEGAVCGDDRYSGRAVVDATFCFKNRLCHTCLNAVDSSECTTRTCFPEDACQNEVAYAVDGSVSMNKSCVVMMNCQRAASSVNQAQCRQTDGGASRCIYCCQSDGCNQELNTINDTYVFPFRKPLVITTAAPSTTDTSHVTTDSPMTSFPVTTHNWVTMQTHTTGRTPTPLLETHPGTDSVVASSDPVSTSRLLYTGTGSHTSTSFPETASWRTENKVQTSAAYMTKEASSAGTESPTTPPFLGTDTAPTEIMLETSEPFSTTGTATFGTHLSASSGHLSTDTSHTDIGHQTTPSISTDFEQTNSWRSPTEWTDNKPQTATATSPSAHFTFTDRGLQSTDNSLVSETQPTDSGRDTPPPYQVTSETPLGTAASSPSTSQPTTESKSSSPSSEVPPSHMCPEEVTEGDTGVVTWPALIANRTAVVPCPYPSLTDPETDRYARRTCFGYASIGWVIWEEPDMSECPTASGALEELIRINITYDNVLDVSDQLKNVTSYAPALTADDVAVVVDALKSLLEALIRYPEKGQEIFLDAMVTANQMTSVKFEKLVESQKINRTTSRLLQLIDEIALHVPLLNTSTLTSESRAFDVIILDVADQSIDSLLFGGLLENNNVKPFVVLNGSAPENATDLIGSVLLPPSLLHILGDQLSRTQFLLYQDTTYFNVVTTSVEHPFGDLKPAPEGAVTLLSSAVISAGMGNLSVVDLREPILMQLKRTHTEAKNPQCAYWDTAANDKQGGWSTKGCEVNFDLSDSTSVVCECNHLTNFAMLMDVYNSGEPDPVHSKILAIISYIGCSLSILALTLAIATLGCCGEEPKYRVTGSGSLNMGTNGKARADRHTNILIHLSVGLILSDVSFLLNTVAVELELGRHMCVGMAVVTHYSLLAAMAWMALEAFNMYLALVLVFDKYYSRFMLKMCLFGWGAPVIIVATTLSINFPDHYGLFNGICWLARIPFLASFLAPVCTVLLFNLVVFVAVTWQLCKMRRRNISQSRRRFDLAAQFKASASITFLFGLTWSFALFGIGEANLAFSYLFAIFNSAQGFNIFVLQCLLKPTIRQRWMRVLRWQREDINGSSKSSSAKDTNNVELFKVKGDGGGHTNGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSJ9</accession>
    <name>A0A8B7YSJ9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein regulatory complex protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">IQ domain-containing protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110982268</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the nexin-dynein regulatory complex (N-DRC). Interacts with CFAP52.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DRC10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096259.1">
        <property type="nucleotide sequence ID" value="XM_022240567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSJ9"/>
    <dbReference type="GeneID" id="110982268"/>
    <dbReference type="KEGG" id="aplc:110982268"/>
    <dbReference type="CTD" id="75732"/>
    <dbReference type="OrthoDB" id="536093at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042815">
        <property type="entry name" value="DRC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31598">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="468"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022096259.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="63910" checksum="E3037B924E448901" modified="2022-01-19" version="1">MQYINGNATSVGKWVCNEKGNNPEVCSTHAVHLFSTPVGLHHRAPHLQPRKLYRKAQRPIKMAFADIAVMETVRLLDKVRAEGPKERPERISKEPPQFKAVGLHKTKSKEGKQPKTDPLRVLDPGRKKLTTVESQRVLAVLDEAIKRTEVVSLLPYVIENLDRFGVVLGVELVTALEEQSRMKNLYADACTQLNAIRNPEPVLASSVSRRSSALSQRSAGSQSRASSRHSSIIATENDVSDEEEEDEMGISEEEEQLMQTLATLKQQMSFSTRNILRLLSLNPAAVNAVRAERKQRDQEAGNLITYLSELRGFILERLLTTPLEEKEKTDYLTHITIRERNNAQVIKKLSAELQAAEDEKDEEISKRNEEIRRLKAELNQIEKFSEEHIRRTKSEADKQQQADAKNSDGKQAKLQAELQALKTQLATNTAEHRESELALRKRKYKIETEVENWIQKYDTDMGERQDEYEDLDTVYTEEKAQLNELEERFKTLEVEYTTIVEERRVAQEKKEREEKELALMIKGATVIQAFWRSYKCRKALKAKKKKGKKGKKGKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YU63</accession>
    <name>A0A8B7YU63_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110981560 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094881.1">
        <property type="nucleotide sequence ID" value="XM_022239189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YU63"/>
    <dbReference type="GeneID" id="110981560"/>
    <dbReference type="KEGG" id="aplc:110981560"/>
    <dbReference type="OrthoDB" id="10070632at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022094881.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23916" checksum="6049C1974ECC3518" modified="2022-01-19" version="1">MINTDCSCGSKSVACDYQRCTVVCTNDVRSDLTCLTHTRTGTCTFRANTLPEEIMSRRNREYKDVVQKLVGRQTNAARGSPDQQRRLQQRHMLQQLRQHVSEARYETGEAVSHIQEEMYKLEARFSQPGSLDSDEGITMPQATGNHASVSPCNSAAASSTPDKYQSDTLRAMQDLILKRRESEKDDSDPHEAGDEAMKMDRGLVHSSKDSHMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWB6</accession>
    <name>A0A8B7YWB6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoside diphosphate-linked moiety X motif 22-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110982685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022096977.1">
        <property type="nucleotide sequence ID" value="XM_022241285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWB6"/>
    <dbReference type="GeneID" id="110982685"/>
    <dbReference type="KEGG" id="aplc:110982685"/>
    <dbReference type="CTD" id="84304"/>
    <dbReference type="OMA" id="TCYRDFI"/>
    <dbReference type="OrthoDB" id="242473at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052751">
        <property type="term" value="F:GDP-mannose hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055295">
        <property type="entry name" value="NUDT22/NUDT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31835:SF1">
        <property type="entry name" value="URIDINE DIPHOSPHATE GLUCOSE PYROPHOSPHATASE NUDT22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="122"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022096977.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33654" checksum="4E1CDB172C5F175D" modified="2022-01-19" version="1">MTNMDVEFTLDFVAPKFPGIPPSKLQVQLCKDYNRKLLPSNETNIDRIWELRRKNNPKLYNGSKFRFHTIKAGSFGEDSCSVTFCLGLTGYKDFIGTNWADNAAELSALGKKDFANSQAYMADALGVSAFVQTQDDLVIFIRRSASVGEAQGLWDIPGGHPEPSEVKGGSSKLEEITLSDLAELDVRNELINSAIREVRDEINIPESKLGEPYLMGVSKNHTCSGRPGMQFFVKCALLSSEVREMYQAGGSEAEESTELKLIHLSDICHLEGSDMWKEMAPLGKACVQLYITVRSNLPGSANDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXZ9</accession>
    <name>A0A8B7YXZ9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110982904</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022097365.1">
        <property type="nucleotide sequence ID" value="XM_022241673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXZ9"/>
    <dbReference type="GeneID" id="110982904"/>
    <dbReference type="KEGG" id="aplc:110982904"/>
    <dbReference type="CTD" id="64841"/>
    <dbReference type="OMA" id="NQRYDWI"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000043">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="42"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022097365.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21003" checksum="32A2C5C5BF70730C" modified="2022-01-19" version="1">MENGMEDILMYDKSLLTGIDFEGRSKVKFHSSASPSNPGDSLVLRPLSTGDFERGYMQLLSELTVVGEVTLDKYLARFNKMKEGGMYYVTVVEDTSRNCIVASATLILEQKFIHECALRGRIEEVVVHKDYRGKQLGKLLMSALTLLSQDLGCYKTTLECGESNIPFYEKFGYVKDKEVYMQNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY93</accession>
    <name>A0A8B7YY93_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Vesicular inhibitory amino acid transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110983056</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097656.1">
        <property type="nucleotide sequence ID" value="XM_022241964.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097657.1">
        <property type="nucleotide sequence ID" value="XM_022241965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY93"/>
    <dbReference type="GeneID" id="110983056"/>
    <dbReference type="KEGG" id="aplc:110983056"/>
    <dbReference type="OMA" id="FGENTNP"/>
    <dbReference type="OrthoDB" id="6021076at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF689">
        <property type="entry name" value="VESICULAR INHIBITORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="70"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022097656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022097657.1"/>
        </source>
    </evidence>
    <sequence length="477" mass="52670" checksum="E24264789503CE72" modified="2022-01-19" version="1">MNHLRSLGNQLRSSILRYGVPIYEAKGEDIELCSSKAGETTQGSLQPNGHINLADTKRDGVPPNQDTAGTSSVWQAGWNVANCMQGIGMLSLPYMVKEGGLAALITMAVVLIIGNYTSKVLVYCLYEDQLNLESGEKPHLVRVRKTYADVADACYKSGGTVLNIMQIIDVIAVAALYLELAGSLMVDTFSMSGLSKLTWTVLCGVLLLPTIFFRHLTKISWLSCFAVLSLVIMFFSVVWYSLGKSIVWDITSVPAFNLQQYSVSASIILFNFGTQFIMPGVEDSMRNRAQFNRMVNCTYFITGVLNIAYALFAYLSFGLETKEFITYNMPLGPLQAAVSMLFVIKSLLSYPLMLFLIVNSVDSMKLSFLPPCSGATPDRMPPAWAMIFRALLVLFTLFLAVVVPHFTLLMGVTGSLTSPWLDFIFPCLFYLKLKRKSLAWWEVVINWVIVGVGLVGGVVGLIYSMKALVNAYAEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYA3</accession>
    <name>A0A8B7YYA3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110982956 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097465.1">
        <property type="nucleotide sequence ID" value="XM_022241773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYA3"/>
    <dbReference type="GeneID" id="110982956"/>
    <dbReference type="KEGG" id="aplc:110982956"/>
    <dbReference type="OrthoDB" id="6287408at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034250288" evidence="3">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022097465.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="18702" checksum="2E4D6C110E4B7076" modified="2022-01-19" version="1">MNVQAASCSTALLLGLAYVQIHAVSSLKCYQCTNFVASNDNLGSLQSNEACAGATFDPNGVVLQDCGTVFGQTPMCEKWEGKFTVNVPFLGNTAVTGQVRGCAFVPVGELVDGCASSTQLTGLAKDAVRLIVSFFTTGEVEGTYCSCERDYCNTAPALSQTAPLLVMIGLLFSQVFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZQ1</accession>
    <name>A0A8B7YZQ1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110983194</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022097985.1">
        <property type="nucleotide sequence ID" value="XM_022242293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZQ1"/>
    <dbReference type="GeneID" id="110983194"/>
    <dbReference type="KEGG" id="aplc:110983194"/>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF15">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="7">
        <location>
            <begin position="606"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="865"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="638"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="657"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022097985.1"/>
        </source>
    </evidence>
    <sequence length="903" mass="100911" checksum="2F2B490CCC2F00A7" modified="2022-01-19" version="1">MTFEFTQTSSADDNISIDTEAGQKSNHRQTEEHAGKAVEFASSQIEDPPARQHGGSGEGDANTHTWLESKHPGIPTSLLTRRHLMETPKETSGKKRLRQTNLEDCFGVGIKRHRSSQGEVEASLVEDVEQGSMSSRPLGESSELRRRREQLAAAAERRRASQSPYSTPPHDAPSSPDSNQGSEEVTDKSTEKTSRTHGSKGTVSKPSTSTAGNSNTGSEVVANSGRNFESVFAYLEEDSEACGRASASSTRSYPSNRTRSKVGEATPGTSVERDNLGGHSSQGTADVSQKTRPDANALVEEDEAAVAVGDVSPTQEYDASLPLFSDSEPHSSLDDEVQVNKDATRIEWRGVDPSALNRAPACRQTLPRLQPSHSHTVLFRPHIRSGAPPRPFPDAYRDTWDAHHVRMPCSPENLYPVDDKNGQKKVQSRWELIETTLLKPIQNSWDLEEAILTYNARYCSKWNFAGLHHFFTEEVDRREARHFFDQLLPKMVELALMLPKLCTQAIPLLKRQESHTITLTQLQIASLLANAFFCTYPRRNAQQKKSEYSRFPDINFNRLFEGSAKKSSTNMRKAEKMRCIINYFRRVALKAPTGTVSFTRRAVTAMPEWEKSTNTLTKFHGNVYGTIEDQGEGMLQLDFANMYIGGGVLGHGLVQEEIRFMICPELIVSRLFTEVLEGNECLFVKGAERFSDYTGYASTFRWNGDYQDTIPRDAWGRKETEILAIDALVFRCFEDQFKPQLLRRELNKAFCGFYGDGTLAANLPAVATGNWGCGAFGGDARLKGLLQMMVAAECHRDMAYFTFGDQRLCYELHKMNEFLVAQGVSVGDLWLVLQRYRTEVLQRKAKRNFTNLYTFIYQVYNDVESSTDEKDGEEGAEQTGGLSRGVDDSDDGSLSPDYKVDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0M2</accession>
    <name>A0A8B7Z0M2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C10orf107 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098330.1">
        <property type="nucleotide sequence ID" value="XM_022242638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0M2"/>
    <dbReference type="GeneID" id="110983397"/>
    <dbReference type="KEGG" id="aplc:110983397"/>
    <dbReference type="CTD" id="219621"/>
    <dbReference type="OMA" id="TELMACT"/>
    <dbReference type="OrthoDB" id="2126027at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032727">
        <property type="entry name" value="CLAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457:SF3">
        <property type="entry name" value="CILIARY-ASSOCIATED CALCIUM-BINDING COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28457">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14769">
        <property type="entry name" value="CLAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022098330.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37256" checksum="8441B9C36D6A2797" modified="2022-01-19" version="1">MASSSTKKGKGKSSQITIQITGKGSEAYKDIDWKTLSDDEAKAIEKEASLAWKVLSNTQTQALQDLPVEEVEKKLSEILKLTSPEIDLCESVLLDYYVSGFWWAKERGFTTQQLSGFFTVLHQLLENIREKQLSLTDNLSEFRKTLVGIGADNNTPSRGLDFFDLEHAKAITDFLQSTLFQHHKMYEFLFHSERKEEIVGTELVVDVLPPAAMPHPPPLDEGLREEVYLRHIAPAPPTPSPEPQPQEGSTEEEGVSDRGETPKTSEEQGAEAVSSGEQEDLLAGVTPEEVKTMFDRVSKELFAGLQNDISEKLMEREAEIIGRINKIHRVAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1E6</accession>
    <name>A0A8B7Z1E6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Metalloproteinase inhibitor 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I35 (TIMP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098797.1">
        <property type="nucleotide sequence ID" value="XM_022243105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1E6"/>
    <dbReference type="GeneID" id="110983671"/>
    <dbReference type="KEGG" id="aplc:110983671"/>
    <dbReference type="OMA" id="SNITCIH"/>
    <dbReference type="OrthoDB" id="6041373at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.370.10">
        <property type="entry name" value="Tissue inhibitor of metalloproteinase-1. Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027465">
        <property type="entry name" value="TIMP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF33">
        <property type="entry name" value="TISSUE INHIBITOR OF METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0481">Metalloenzyme inhibitor</keyword>
    <keyword evidence="4 13" id="KW-0483">Metalloprotease inhibitor</keyword>
    <keyword evidence="5 13" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034128342" evidence="10">
        <location>
            <begin position="28"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="11">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared with metalloproteinase partner</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="30"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="166"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="171"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098797.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25254" checksum="96FE32FF0AE914B0" modified="2022-01-19" version="1">MTRSSNLIPVPLLALALIVELCPSVLSCLCQLSHPQKQFCDADLVIVGTIQTKQSLHGPPHPAILPDEPTIISYKIQISNVKKGQRYAGQLWNVQDNELIVNTSATTVSCGVPWLEVGQRYVLTVTLVKGKASLLYCNFHRTYSELTDMQRRGINGAYSRGCEPQCQIYTCRPYGHCPSTTSNITCIHGNHQTNKDCYYRHGYCRAKSAGKCSWKTSPTFNACIDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2V3</accession>
    <name>A0A8B7Z2V3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arylsulfatase B-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110984263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099954.1">
        <property type="nucleotide sequence ID" value="XM_022244262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2V3"/>
    <dbReference type="GeneID" id="110984263"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16029">
        <property type="entry name" value="4-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000007">
        <property type="entry name" value="Arylsulfatase family, member J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047115">
        <property type="entry name" value="ARSB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10342">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARYLSULFATASE B"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
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            <begin position="25"/>
            <end position="538"/>
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    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="356"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001913"/>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
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    <evidence type="ECO:0000259" key="8">
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            <dbReference type="Pfam" id="PF00884"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022099954.1"/>
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    </evidence>
    <sequence length="538" mass="61117" checksum="A37475EDCC899B91" modified="2022-01-19" version="1">METRKEHAMQHFTTIFLLTSVVLALSTLGDCHWNSTNPPNIIFILADDYGFNDIGYHGSKIRTPWLDKLAAEGVKLENYYVQPICTPTRSQLMSGRYQIHTGLEHWIIWDVQPNCLPLDDVTLAEKLKELGYATYAVGKWHLGFYKKDCWPTRRGFDTFFGYYTGSEDYFTHRRGCGMPGFNCKGFTPGLDLRDQEQPTHNYNGSYSTHIFTEQAQQILENHNSAKPFFLYLPFQAVHSPLQVPEKYIDPYKHIADKHRRIYSGMVACMDEAIGNITQTLTHLGLWDNTVLIFSTDNGGQIHHGGNNWPLRGWKRSLWEGGIHGVGFVHSPLLKETIRGMVNSELIHVSDWFPTLVAGIAGGNVSGLLLDGYNVWDSISQGKSSPRKEILHNIDPIPYPSLPYMAEYEPQGGVFYPDAYFNTSNNLPGSYNTTIRAAIRVGDWKLLTGYPGNSSWIPPPDSGIVPIHPVEQKSKYVWLFNIREDPNEYHDLSDARPDKVKELVGRLQYYYSSLVPPFYPPGDVRANPALHGGIWTNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3U2</accession>
    <name>A0A8B7Z3U2_ACAPL</name>
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        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110984108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110984108</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099626.1">
        <property type="nucleotide sequence ID" value="XM_022243934.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099627.1">
        <property type="nucleotide sequence ID" value="XM_022243935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3U2"/>
    <dbReference type="GeneID" id="110984108"/>
    <dbReference type="KEGG" id="aplc:110984108"/>
    <dbReference type="OMA" id="CITSFFM"/>
    <dbReference type="OrthoDB" id="7455636at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031720">
        <property type="entry name" value="DUF4728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15860">
        <property type="entry name" value="DUF4728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022099626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099627.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20559" checksum="E9C137C89FD995B6" modified="2022-01-19" version="1">MPILKSCCCCGLQRGCIVAGIFSVVTSLAWAAWGGYNLYESGILQTESFSDIAPFYYGYAVGVGLWVFLFLSSFLLVAGVCCDRRGLLIPYIVAAILAILVHCALCALYLYILILAFDEGYVNDVFNLTALSLSGVFIVLDSLSLLCVISRYQELRYGEDARLVRQESVFPVQSPSIAMTASQPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z585</accession>
    <name>A0A8B7Z585_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Relaxin receptor 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110984685</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100793.1">
        <property type="nucleotide sequence ID" value="XM_022245101.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110984685"/>
    <dbReference type="KEGG" id="aplc:110984685"/>
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    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15137">
        <property type="entry name" value="7tmA_Relaxin_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002131">
        <property type="entry name" value="Gphrmn_rcpt_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00373">
        <property type="entry name" value="GLYCHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034938970" evidence="17">
        <location>
            <begin position="23"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="577"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="717"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="763"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="558"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="911"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022100793.1"/>
        </source>
    </evidence>
    <sequence length="938" mass="105799" checksum="2DE139D9C2203284" modified="2022-01-19" version="1">MRKLHNALRMLFVLHLCASRRAEQDGAIIRHIQRRAVDAHKHCGKDFPCLNSTQCVPQDSICDGTPDCDNGSDEWEVEECRDWNLAKMWDNFFGTKNDDSGEEEEDDLDQGLRPQQTVFDAHGHCGEEFPCMNSTQCVPREAICNGKPDCDNGSDEEEIVCRNKKMRDNIEDIRQEIPCEEGTFPESCDCFVEIEQTRTAELPSLASPYNTTGDASTYRDAYDIDSNSTDGVRYGSEVRGVVIGIRLDCRAKQLTNVPRNLPNNTISLDLSDNKITHLTKKDLTNLPQLRQLLLSRNKLKRMEEGAFKPLTDLETLRMIACDLEDVQQRMFAAQKRLVTLDLRYNKLTRLVKNSLFGLRNVKYFDIRGNQLSEIETGVFEDTPKLYFMLVSQNKLSSIPANLLRPLRELRTLDVHRNDISVIETGAFSTNTKLIELNLRDNKLTEIRRGIFHSLTSTITLSLSNNSIRHLEQDAFAGMNNLQTLKLTKNPFTSLPVGIFDQLISLKAIYFDHFSLCGYAPHVRLCMPKSDGISTAENLLGNILLRFAVWFVALLASLGNAFVLLARCFVNEDKKTHSFFIMNLAVADLLMGLYLLIIGIHDVIFRGSYILHDLTWRNSSVCKLSGFLSLLSSEVSIMTLTVITLDRFLSIVHPFRFKNRSLVHARLLMVFLWLLGIALATIPLLHTAYFGEFYYGGNGVCLPLQIDQPFADGWEFSLVIFVVFNLVAFTFISYAYLMMFMTIRRSNLAMRSTKKNQDWALVKRFTLIVATDFVCWMPIIIVKFVALGGVSVSQSVYAWFAIFVLPINSALNPILYTMTTVLFRQKILAPLGIVKAKRKKGYITGVSVDETSTMSKNSGTRLSIISNKSRGGSLNGRFNSQKKLKNLSSLDSTDESVTCSAAQTTSLKIKKHRAATADYHELPTSDPDCAPSGVNDDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6C7</accession>
    <name>A0A8B7Z6C7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110984532</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022100507.1">
        <property type="nucleotide sequence ID" value="XM_022244815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6C7"/>
    <dbReference type="GeneID" id="110984532"/>
    <dbReference type="KEGG" id="aplc:110984532"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000144">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="18">
        <location>
            <begin position="222"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022100507.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="59346" checksum="23A4F8E95C9D0F22" modified="2022-01-19" version="1">MSEASPAGEGAPSKKALKKQQKEAEKAAKKAERQAQQAADAEAAEGEDYAKDRYGVARMIQSHEKPDRKLVKVGSLTSALSDQTVWVRARLHTARGKGKQCFVVLRQQQFTVQGILNVNETISKAMIKFVSGTTKESIVDVEGIVAVVPQKIESCTQQDVELRIQRFYVVSQSAPRLPLQIEDASRPKGEEEDGVQAPTVNQDTRLDNRILDLRTQTNQAIFRLEAGVCQLFREALRKRDFVEIHTPKIISAASEGGANVFAVSYFKTSAYLAQSPQLYKQMAIAADFSRVFTVGAVFRAEDSNTHRHLCEFVGLDLEMAFDYHYHEVLDVIGGMFTDIFRGLRDRFATEITTVNKQFPAEPFKFLEPALRLEFPEAVKMLREAGVEMGDEDDLSTPNEKLLGRLVRAKYDTDFYILDKYPLAVRPFYTMPDPNDPKYSNSYDMFMRGEEILSGAQRIHDPEFLSERARHHGIDLETIKAYIDSFRYGAPPHGGGGIGMERVVMLYLGLDNVRKTSMFPRDPKRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6J6</accession>
    <name>A0A8B7Z6J6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110984572</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100582.1">
        <property type="nucleotide sequence ID" value="XM_022244890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6J6"/>
    <dbReference type="GeneID" id="110984572"/>
    <dbReference type="KEGG" id="aplc:110984572"/>
    <dbReference type="OMA" id="PMITIGI"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF165">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100582.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="20225" checksum="11AC69B54BF8FCBA" modified="2022-01-19" version="1">MSDDRRPMMITGILHIVVGIVQPVLWGISWAFTGYYSTVVSEVWGSVAFFIPTGVLAILVAKGNNRGLAIASLIMSILSAIVALVIFITNCITAGLNFSNYFAAHGAFSILALLLGIFEIAVSIVTSIYSSKIYRNAAIPTQAMTVQATTAYPSAYPAVQQYPGPQAQAQYPGPQAEAQQYPPQEQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z853</accession>
    <name>A0A8B7Z853_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GPI transamidase component PIG-S-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110984863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101137.1">
        <property type="nucleotide sequence ID" value="XM_022245445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z853"/>
    <dbReference type="GeneID" id="110984863"/>
    <dbReference type="KEGG" id="aplc:110984863"/>
    <dbReference type="CTD" id="94005"/>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022101137.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="59286" checksum="AB3D5E76922C919C" modified="2022-01-19" version="1">MSDKESHNDEDVRSPMYAALAVAFIAVVFGIPVWWLSTTTYRASLPYQEIQELPTKQTNCLIPVTVISCLTQEEKQDFDNFQAELNALLQSADQMSLLSIQYSIDWKLCSFKDQEVLGTSSSLAELDRRLSTSSDIPHGQVTIYLVSQGYSLLNSTDSFVGTGRVAVATPKDSVVASLIRTRFANEDAMARVYLNAAGARRLDKGYELSFSLLNPQPATFNAQWNIQEAVQAYLNPFLQKLSEFAEFTVNSQVLHFTGLSIKPKHNEEDDSYRLSQNALPLIINPVEAKLGSHVSTNPSLNFLLFVPRSRHLPLFITDNKGQPVDTNAFLSPRWGGVMIHNVPKPSENDSLPLAVKIDTRRAMEVFLAQLRLLIGIPQQAIQDNVILAAPDKTGITDWEYDVLLRVRTLENLATASSTLVSLAQLLNQIGNIVIRDDIANQVYQAVSAIKQGHTYLQRGNLYRAFHDSKRAIAASEKAFFDPSLLELLYFPDDQKFAIYIPLFLPVGIPVLSSFVKALRWMKTKMKPKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8S4</accession>
    <name>A0A8B7Z8S4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">2',3'-cyclic-nucleotide 3'-phosphodiesterase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110985385</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102063.1">
        <property type="nucleotide sequence ID" value="XM_022246371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8S4"/>
    <dbReference type="GeneID" id="110985385"/>
    <dbReference type="KEGG" id="aplc:110985385"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009214">
        <property type="term" value="P:cyclic nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1740.10">
        <property type="entry name" value="2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008431">
        <property type="entry name" value="CNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047325">
        <property type="entry name" value="CNPase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10156">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10156:SF0">
        <property type="entry name" value="2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05881">
        <property type="entry name" value="CNPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Cyclic nucleotide phosphodiesterase catalytic" evidence="9">
        <location>
            <begin position="273"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide phosphodiesterase catalytic" evidence="9">
        <location>
            <begin position="451"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022102063.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="60774" checksum="D3194C70A21DA351" modified="2022-01-19" version="1">MSAKPLLLSTLQAYLWMEFKNLFKNLRALSEPIYRMKRNDKKEDNEEMFTSNLQMEGQPWTTFQANQPNQIPSSVRPTLPSRLIVLATISLMVLLQTCILMMSSTKQQSNSHKSTSAGATDHGLSKYPFLDDPQAIKYISTQIKVMFFLHMTSGKETSALAKDITNTYKNSAICCFYNSRGSNDSPALGNVYQTCKNQIEDSCKKGLQVIVVNGTDREHLELQGYFTVAHQYNYTTVVVQPNATLDHFDAQRSPSEPIGDASKGQDLPKILYPFFYGWFLGFNISVDTQNYGRKIFHECRQQPKFVEIFKKYALPGSPRNSTGGLDFDRYFSLDGFITGTTLLHCTSFFSNYSERAGSQQYATSPAVRQGTGDVYNLLVIGFLITPRTFGARIRLSSEELCLWESNSTSGNLAAVGAASNADKIMQQKQLQRFSQEKLTFDLIIDNEVPCPKDWHPTKFSPTCGRGSRAHLTLGTGKDIEAQQTGSDLNMIILKELEAVAKKEDILTLRLESGTVRCYGEGNWAVYLDKPFEIGALFTGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAZ1</accession>
    <name>A0A8B7ZAZ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Kelch-like protein 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC110985795</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102816.1">
        <property type="nucleotide sequence ID" value="XM_022247124.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102817.1">
        <property type="nucleotide sequence ID" value="XM_022247125.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102818.1">
        <property type="nucleotide sequence ID" value="XM_022247126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAZ1"/>
    <dbReference type="GeneID" id="110985795"/>
    <dbReference type="KEGG" id="aplc:110985795"/>
    <dbReference type="OMA" id="SEIWSIH"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF5">
        <property type="entry name" value="KELCH-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="56"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022102817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022102818.1"/>
        </source>
    </evidence>
    <sequence length="617" mass="69527" checksum="D9F96851B9462F0F" modified="2022-01-19" version="1">MKSAMSSRIATIPSPLRSDVSALQRQDSSANHIHHTSHPATLLEQMNALRKDKMLTDICLESDDGQQFHCHRIILAATCPYFSAMFSSHMGETSSDKVTLHDIAGSILGQLIDYCYTGSLLLTDDIVNDVAEAANFLQFSAVEEECVRVLQNRLNAMNSLETEQVANRLFNRQLSAQAHGYSVKNFSDVAFTQDFLDFTQEQIEDFISKDVGVDSEEEVYEAVMRWVYHDKDKRKTAIPSLFEKLLFEMMPEAYVLKIAASEPLLQEFDDCMKIVKKAHSFHGAKSRSSERSISSSTELLSRANSMRAYSEVMILIGDLEFCYRMEGCDKKAINMLMYDPKHQKWECLPESPFGLGSSEFATCATVINNDIITVTNWHRAWLYSTSQSKWSLLTNRMQGRNGGCLVTLNNDVFILGGLKPVITSRMTSVQCFNQATKQWVDVAPMTEALLHTTSAACLGKIYVVGGSSGSRYVSEMLCYSPDYNKWISCEPLPSRLMRPQMVVLTGSLYVLGLENDFAMAMYRFDVRNQQWTVMDAPMISRHGATLSVCNNKLFLVGGKICSSDYRETNEFTVEYFDPDSEIWSIHGESQWVLNGHQAVTVLHPAFSPSRYLGPKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC38</accession>
    <name>A0A8B7ZC38_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box/SPRY domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110985996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FBXO45/Fsn family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103249.1">
        <property type="nucleotide sequence ID" value="XM_022247557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZC38"/>
    <dbReference type="GeneID" id="110985996"/>
    <dbReference type="KEGG" id="aplc:110985996"/>
    <dbReference type="CTD" id="200933"/>
    <dbReference type="OMA" id="ATKRASM"/>
    <dbReference type="OrthoDB" id="2398163at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060386">
        <property type="term" value="P:synapse assembly involved in innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22111">
        <property type="entry name" value="F-box_FBXO45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12907">
        <property type="entry name" value="SPRY_Fbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000017">
        <property type="entry name" value="F-box/SPRY domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035784">
        <property type="entry name" value="SPRY_FBXO45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF7">
        <property type="entry name" value="F-BOX_SPRY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="61"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022103249.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28281" checksum="715A9FF1026987BE" modified="2022-01-19" version="1">MAAASAASLPAKILELIFSYLDLADLLNCSTVCKAWHNCLNDENSLVWRVQCVRRIAAEAQKGDLLSEVPSYKGKLRALFHAFNPGDCSRNVYIKPNGFTLHRNPVAQSTDAARGRRGFRKGRHAWEVWWEGPLGTVAVVGIATKNAPLQCQGYVALLGSNDQSWGWNLVDNYLSHNGDHQGNFPQCNNAPKYEVGDKIRVILDMEDNYLAFERGYEFLGVAFRGLPDEQLFPAISAVYGNTEVTMVYLGEPLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCN1</accession>
    <name>A0A8B7ZCN1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransferase family cytosolic 1B member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100946.1">
        <property type="nucleotide sequence ID" value="XM_022245254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCN1"/>
    <dbReference type="GeneID" id="110984770"/>
    <dbReference type="KEGG" id="aplc:110984770"/>
    <dbReference type="OMA" id="MERAPFL"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100946.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34538" checksum="D56F9532B4E1A4D9" modified="2022-01-19" version="1">MAERTFRSLQWSDRELWYEYNGGIFLFAVVPPECWKEIEAFQARPTDICIASPGRSGSHWMSRIINLLLGFDNPDFLNDPPLENLLISAVTDPNAPQRMGYHVVAEMPSDRPRVISTHVPATHLPKSFWNTEGVKILFMLRNPFDTCRSAFKLISNLVSGPMSFSSYLKFSLDEQKLGSCTLQSLTRSYWERRHQKNLLFVYYEDLRENFRQTVTSVANFLEIPVSADQLDMIQERSSLRVMRAMEAKAQTNEGTGVGTLINKGLINKAITEYSEMDIAFVKSKIKEKLADTDIRYVEDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCU0</accession>
    <name>A0A8B7ZCU0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110986146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103488.1">
        <property type="nucleotide sequence ID" value="XM_022247796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCU0"/>
    <dbReference type="GeneID" id="110986146"/>
    <dbReference type="KEGG" id="aplc:110986146"/>
    <dbReference type="OMA" id="VWAYETL"/>
    <dbReference type="OrthoDB" id="10554768at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022103488.1"/>
        </source>
    </evidence>
    <sequence length="713" mass="78979" checksum="9078B0048A0C7328" modified="2022-01-19" version="1">MSLLLKKFCAHVILFHSESDALESTLSEDFEEYILLDEASIEACDTRWREMREDCGGLKDERHRRPAEATDSAWKETGNSLAGGGNGGCTNASDSPSKAEVKMSHGALMVTARRKEAGTRTHKKCQSRCPRERCTGNDDVEVSDCGDEDSGKITADTVDNDIKRAPSETCQIYTPAPGIKVRLIQVQPANQLTANQLPIIRPSNPVRSPQSTNSTSQVSETPITHRSADDGQPQGALGKTASPTGEELQGNLPKPKTFTTKHINPNLGILSSRALKRRVNPPKRQKDLPTRSQEPSSQENCGKTENTLVKKEVSPAERDEESRRRQLNASIIAKIQEESCGTDRHAAVEPGRPADGAVHKHTAVTATPAQPTSLRSAAPAELVTLPPTVLEALTLEQEKGRQLLEKTRQQSKMMMNCLMRQRELRKVDDSANHSRPHPGSDSAVGNSQQPSDIMACADRMVATNDMFRENIQNQMIASHNAWMMLKRRKGMFFAAKRKQDHEGGSLQDEKTANQRCKGVPSDQPRVISNSPGQGTDDLVLYKGKLLKLCWPHPKDTILATKTREAKELPERSNKKRKKNSIHPVAATLQPFSSCQPSEDELDYMYRAQLQLADVNSGTCQKTPAPNSNLWGVELIPSGTVFADEFQADASKPPPSNPLVWAYETLQDPKRRRRPRLKNLQRVVDASKHRTTVQKIKSTRPGPDEVIYVSEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE43</accession>
    <name>A0A8B7ZE43_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">ETS-related transcription factor Elf-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110985944</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103120.1">
        <property type="nucleotide sequence ID" value="XM_022247428.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103121.1">
        <property type="nucleotide sequence ID" value="XM_022247429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE43"/>
    <dbReference type="GeneID" id="110985944"/>
    <dbReference type="KEGG" id="aplc:110985944"/>
    <dbReference type="OMA" id="CDTEVNK"/>
    <dbReference type="OrthoDB" id="8196042at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040034">
        <property type="term" value="P:regulation of development, heterochronic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000411">
        <property type="entry name" value="Ecdysone-induced protein 74EF isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF191">
        <property type="entry name" value="ECDYSONE-INDUCED PROTEIN 74EF ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETS" evidence="8">
        <location>
            <begin position="284"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022103121.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42059" checksum="187DB90508B1B235" modified="2022-01-19" version="1">MACIQVEPVIIQPEAVVCTDNENRDEPPSPEILPSFLKISYPRLDLSALSECKFAERKPNIIQDGPSVIVQSLYNMPLTPGAFGTPTALEYLAEEIEVSCSEDGLCDTEVNKLTSKLSHACDTAGSSENGRDMMAAHALLDISPTTSGEEKSFIAQSKLTTVTQNCSNTGSLPPSPADSGVASDKEADPTQTDAQENDSVLATSCHQPDTHQDPSVIVSMIPDYEVELESDSVNEVQVPYSPEITHNYSKKPSKKSRKSKPRSPDDLHVQSSCSKRKTRESHTTYLWEFLLELLQNVETCPRFIKWTNREEGIFKLVDSKAVSKLWGQHKNKPDMNYETMGRALRYYYQRGILAKVDGQRLVYKFCEIPKNITEVECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE57</accession>
    <name>A0A8B7ZE57_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 41A-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110986011</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TMEM41 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103277.1">
        <property type="nucleotide sequence ID" value="XM_022247585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE57"/>
    <dbReference type="GeneID" id="110986011"/>
    <dbReference type="KEGG" id="aplc:110986011"/>
    <dbReference type="CTD" id="90407"/>
    <dbReference type="OMA" id="DNRDCLF"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="87"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103277.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28126" checksum="C3EE292A12F326B5" modified="2022-01-19" version="1">MAVVTAICTVGLAFAVATSWLYLLSINLPSLPENLHLQNESIELKFPTNLDDLTDMAEVLQDYKANHFGYVMLLFCSAYLYKQTFAIPGSVFMNLLGGALFGIWYAFPLCCVLTATGASLCYLLSHLCGRAVVMKYFSQRIQPLQKKVEDNLDSLFFFLLFLRLFPMSPNWFLNISSPIIGIPPLQFFLSVLIGLMPYNFICIQTGSILSSVTSLNEIVTTGVMLRLAGMALVALLPGLVFRKYKRRMKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEW8</accession>
    <name>A0A8B7ZEW8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Calreticulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110985218</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 17">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101766.1">
        <property type="nucleotide sequence ID" value="XM_022246074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEW8"/>
    <dbReference type="GeneID" id="110985218"/>
    <dbReference type="KEGG" id="aplc:110985218"/>
    <dbReference type="OMA" id="SRAAKFP"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000002">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000122">
        <property type="entry name" value="Calreticulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009169">
        <property type="entry name" value="Calreticulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF2">
        <property type="entry name" value="CALRETICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002356">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 13 17" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 13 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034478191" description="Calreticulin" evidence="17">
        <location>
            <begin position="18"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="338"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="376"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>an alpha-D-glucoside</name>
            <dbReference type="ChEBI" id="CHEBI:22390"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR002356-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022101766.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="49289" checksum="3C593D14C1FC75C3" modified="2022-01-19" version="1">MNLTFCIVSALISLCSATVYFQDQFDGDWAERWVNSEHKDDLGKFKLSAGKFYNDPEKDKGLQTSQDAKFYAISSKFDSFSNEGKDLVIQFSVKHEQKIDCGGGYVKVFPGDLDQSDMHGDSPYNIMFGPDICGPGTKKVHVIFSYKGKNLLTKKDIRCKDDEFTHLYTLIVRPDNTYEVRIDNKEVQKGNLEEDWDFLPPKKIKDPEAKKPEDWDDNAMIDDPEDTKPEDWEKPEFIPDPDAVKPDDWDDEMDGEWEPATINNPEYKGEWKPKQIDNPNYKGEWVHPMIDNPEYEADDTLYLYKDFGVLGLDLWQVKSGTIFDNFLITDDVKEAEKQANDLWKPTKEGEKKMKDKQDEEERKKREEEEKKRKEEEGDDEDEEGEEDDEFGLSPEDLEGLEEGEDLEADEPPEGDADEETQAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZG07</accession>
    <name>A0A8B7ZG07_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T-complex protein 1 subunit zeta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110985450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102176.1">
        <property type="nucleotide sequence ID" value="XM_022246484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZG07"/>
    <dbReference type="GeneID" id="110985450"/>
    <dbReference type="KEGG" id="aplc:110985450"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000029">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022102176.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="57904" checksum="B05E33BE8C3F4CCE" modified="2022-01-19" version="1">MAAIKELNPKAEIARAAQALAINTSAAKGLQDVLRTNLGPKGTIKMLVSGSGDIKLTKDGNVLLHEMQIQHPTASMIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIVTEGFELAKAKALKILDEVKVAREMDRDTLISVARTSLRTKVHAEMADLLTEVVVDAVLAIRKPEEQIDLHMVEIMQMQHKMDLDTKLVRGLVLDHGARHPDMKKRVTDAYILTCNVSMEYEKSEVNAGFFYKSAKDREKLVEAERAFTDEKVRKVIELKRKVCEGNDKGFVVINQKGIDPLSLDMLAKEGIVALRRAKRRNMERLCLACGGVAMNSVDDLAPENLGQAGLVYEHVLGEEKFTFIEECANPRSVTILIKGPNKHTLTQIKDAIHDGLRAVKNAIDDAAVVAGAGALEVAIHAGLIKFKETVKGRARLGVQAFADALLIIPKVLAQNSGLDPQEVIVKLQEEYAESKQLVGVDISTGEALVAADAGIWDNYCVKKQILHSCTVIAGNLLLVDEIMRAGLSSLKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGG3</accession>
    <name>A0A8B7ZGG3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Adhesion G-protein coupled receptor G4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110986417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103955.1">
        <property type="nucleotide sequence ID" value="XM_022248263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGG3"/>
    <dbReference type="GeneID" id="110986417"/>
    <dbReference type="KEGG" id="aplc:110986417"/>
    <dbReference type="OMA" id="HTNNTEC"/>
    <dbReference type="OrthoDB" id="10037534at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="895"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="929"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="960"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="998"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1040"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1087"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1114"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="12">
        <location>
            <begin position="423"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="10">
        <location>
            <begin position="720"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="893"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022103955.1"/>
        </source>
    </evidence>
    <sequence length="1227" mass="130877" checksum="3AB963ADDE7362D9" modified="2022-01-19" version="1">MELATNGSGTLTTDNTTDTTSTTEVAINSTMELATNGTLATDNTTDTTSTTEVDINGTMELATTGIPTTDNTTGTSTTRGTYEPFTEPSVNINITLESQTEQTTNTTRTNQITTEASTIEAATSGTMELATNGSGTLTTDNTTDTTSTTEVAINDTMELATNGTLTTDNTTDTTSTTEVAINGTMELATTGIPTTDNTTGTSTTRGTYEPFTEPSVNINITLESQTEQTTNTTLTNQITTEASTIEAATSGTMELATSGSGTLATDNTTDTTNTTEVATNGTMELATNGTLTTDNTTDTTSTTEVAINGTMELATTGIPTTDNTTSQVATTEKTTEAATIVYASTEQVITQEAATKDVATSDAIATEQATEATPIERTTEKATTAIATTEQQIVKATTETVATTDATTEDQAIEATTNMQATTDSASPGVDIKCPDSMDLDITDGSPTSLVTWPPPTVSSSTEAANCQPASGSQFSIGNTDVVCDVRDNFGNEARCSFTVAVTAWCPDDIYVISAGFVTFPETRLSETRNTLEECVKNDGTGTMHPRASRLCGGSVQTGAHWQQPVFIDCLQEQNVNEGLDELAEKPITDENVDDVSDALASLTNQTSGIDNKGVASAADILDGITKTGNPSPEVTSDVVQVVDNMLQVDDDSFESTGNASSRIVKSLEAQVSLVLSGGGNFSSVTHSLAVKALHVSSDSVGAHGVGMVARAGRDGEWLKEENINICPSQCDGDNPQSMIASIMLPKEIVDRLPSEPINVGQVPLSFMMYQNDKLFRSRNLLDQYATSYFRTVGSSIVVAAVDGVEIDNLPSNSSVLSTFSLLKVHEEKTDTPMNAECVFWDFKMHGGIGDWSNKGCHLVSSSQKRAVCSCNHLTSFAVLVDVFGQTRTSPALDIISKIGCGVSVISLIITIAVYIGIRSLRVKIPSRILICLCFSLLCLYLIFLVGIEQTSSGNGCLVVAVLLHYFTLASMAWMAVEATNMYLLLVKVINTISMRRFMLHASLAAWGAPLIIVVTILAVDYTQYQSKTYCFLKSGPAFLYGEMAIIGVVLLYNTIIFIMVLVSIYGRNQVRSTADQHRRRKASRRVQNALAISVLLGLTWSFGLLSVLEASNFAFQVLFSVFNSLQGLFIFLLFCLRQDNIRAILLGKLKSVDRSKHVFCLMSGGGKTPLAGKGTETTHGSTNSPSGIELLILSRTSASLYKWPSQFTRQPEYVDNQEHPFAVKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZH74</accession>
    <name>A0A8B7ZH74_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985697</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102601.1">
        <property type="nucleotide sequence ID" value="XM_022246909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZH74"/>
    <dbReference type="GeneID" id="110985697"/>
    <dbReference type="KEGG" id="aplc:110985697"/>
    <dbReference type="OrthoDB" id="10168941at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034473226" evidence="1">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102601.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17289" checksum="F1ADB4016AA13BC3" modified="2022-01-19" version="1">MSSLIYLGVLLLLGCSLITTGHARLNPALRGIVQMNQQYKTALESDDKASILAMYVPDVLVLPEGYPGYVGKEKLGNNMNWISYVGTVEYDIKYLDFLNGNNVRVLELKTSTVKDKQGNIMFKGKTLLFWAWNSKTGVWQIMLEMFNSDQKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIY8</accession>
    <name>A0A8B7ZIY8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Probable G-protein coupled receptor 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110986876</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104842.1">
        <property type="nucleotide sequence ID" value="XM_022249150.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104850.1">
        <property type="nucleotide sequence ID" value="XM_022249158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIY8"/>
    <dbReference type="GeneID" id="110986876"/>
    <dbReference type="KEGG" id="aplc:110986876"/>
    <dbReference type="CTD" id="2845"/>
    <dbReference type="OMA" id="MKKGQRF"/>
    <dbReference type="OrthoDB" id="6156007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="62"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022104842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022104850.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="55636" checksum="8E724A443CEB77C4" modified="2022-01-19" version="1">MSSLLINITTTLVNPTAATNDSIMGMPITASTTNTSSYVYPVPYVVVLSVVLLIEMLAGVLSNLAVLFSYHVNKKFIRSVSDVFIINMNVVDIIICLVSIPATLVAVLSNPSIPLFCFFHEATVSFASVASAVNVAVISLDRYDKISHPLVRKFTMRNVRWILPITWLLSLLGFCSPLFGINLEKFDRVQKRFESEGHHCFYWFFSSRDNHFYELYYIPIFFVATFVMIYAYYGIIRITRVKTIHSALVKATVSMKVDNDRKVVAAAINNKDPEKRVSRTTTIIILTFITCWGPHALVSIVIVARGYASSGEIALDMLERWLVVLGYTTTLMHPILYVFMRRNFRRAFSNSWFARCAVRHRVGAARSAPSQDEPECPRAVLGTIGKRQSDRNLVVSTRVEKNSNLPQTSTKATVHAHVVREEHFQLASSSGIRENIVLLDSDHVDMKEPMTTPHAAYVISPPAIAVKDPTFKCSDSVPISSSVVTEKHKNAHLPNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJA6</accession>
    <name>A0A8B7ZJA6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="RefSeq" id="XP_022105718.1">
        <property type="nucleotide sequence ID" value="XM_022250026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJA6"/>
    <dbReference type="GeneID" id="110987356"/>
    <dbReference type="KEGG" id="aplc:110987356"/>
    <dbReference type="CTD" id="8940"/>
    <dbReference type="OMA" id="VIHNVYS"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000002">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="170"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="816"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="827"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105718.1"/>
        </source>
    </evidence>
    <sequence length="859" mass="97031" checksum="C1FB0B284F65305A" modified="2022-01-19" version="1">MKVALMVAEKPQLAQSLAKILSRGNLHSRKASNGACSVHEYTGNFRGETCRFKFTSVCGHVMGLDFNARYNNWDRVDPVELFAASTEKKEANSKLQIPRLLQQEGRGVDYLILWLDCDKEGENICFEVIDCVGPVMNKNSMRQQVIFRARFSAITDNDIRGAMERLVEPNKNEALSVDARQELDLRIGCAFTRYQTKYFQGKYGDLDSNLISYGPCQTPTLGLCVNRHDKIQEFKPEPFWVLHTEVAHPSGRNLVLDWERVRVFDRDVAQMFMNMIKGQKDAKVTSVTQKEKVKQRPLALNTVELMRVASASLGMSPHHAMQIAERLYTQGYISYPRTETTHYPDNFDLKGTLKQLQSSPWGGEIRELLVQGINRPRKGHDAGDHPPITPMRSASESDIGGEAWRLYEYILLHFIATISYDCKYLQKTVSFIINDERFFCSGKMVIDPGYTTFMKWQAINTSETLPTFQVGDVCSLNEIKIIERQTSPPDYLTESELITLMEKHGIGTDASIPVHIENICQRNYVKVESGRRLVPTRLGIVLIHGYQKIDPDLSLPTMRSAVEEQLNLIAQGKVDYHIVLRHTLDIFTRKFQYFVEQIQGMDELFEVSFSPLAATGKPLSRCGKCHRFMKYISAKPCRLHCAQCEETYTLPQNGSIKLYKEIRCPLDDFELVLWSSGPKGKSYPVCPYCLSNPPFPEMRKGMGCNECTHPTCPQSIIKLGVAQCIECDNGVMVLDPSSAPKWRLACNKCNVIMNIFEDAHRITVSDFHCEKCEAAILDVDFNKTKTPLADNETHRSGCMFCDPVLSPLIEAKHASIHRGGRGGGGRGRGRGRGRGRGRGRGRGGKAPKDKMSQLANYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJR8</accession>
    <name>A0A8B7ZJR8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tektin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110987034</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
            <location evidence="10">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tektin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105125.1">
        <property type="nucleotide sequence ID" value="XM_022249433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJR8"/>
    <dbReference type="GeneID" id="110987034"/>
    <dbReference type="KEGG" id="aplc:110987034"/>
    <dbReference type="CTD" id="83659"/>
    <dbReference type="OMA" id="LAMVMDE"/>
    <dbReference type="OrthoDB" id="10054259at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048256">
        <property type="entry name" value="Tektin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000435">
        <property type="entry name" value="Tektins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960">
        <property type="entry name" value="TEKTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19960:SF25">
        <property type="entry name" value="TEKTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03148">
        <property type="entry name" value="Tektin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00511">
        <property type="entry name" value="TEKTIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="24"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022105125.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46826" checksum="AEEB1D19A49901DA" modified="2022-01-19" version="1">MAKLISAPPKFTHQEWAYSNKTNYNNAEKQRASAERLIDESERLIDETDEVTKRTQRDVNKKFEQRIHNVTFWKDELNRKLDDAKKEIDTLLAYKTRLQNALEACKEPLAIVNHCLLFREGREAIDLVHDDVEKNLLKERETIEGVMALLQRTLDQTTEQIRIMRSRRYTLEKDLTDKFAALDIDQDCRELRDDNPHLTFKSGAAKIETNSVTPEDWQKFTNENILKTERDRKNAVDLRAVIDSLLETTEDDMKKQVSDTNLAFKKRIRETQDTKSELETHLAKVVGQIQEMEKNIQSLTKAVEDKMGPMKLSQTRLDTRTNRPNVELCRDPVQYRLINETAEISQSVAKLQATLDEAEDQLKGLIRQQQTLEEDIDIKSKSVYIDNVKCMGLRQSINIMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJW7</accession>
    <name>A0A8B7ZJW7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">N-alpha-acetyltransferase 20</fullName>
            <ecNumber evidence="9">2.3.1.254</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Methionine N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">N-acetyltransferase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">N-terminal acetyltransferase B complex catalytic subunit NAA20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">N-terminal acetyltransferase B complex catalytic subunit NAT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NatB catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110987155</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-terminal L-methionyl-L-asparaginyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50484"/>
            <dbReference type="Rhea" id="RHEA-COMP:12694"/>
            <dbReference type="Rhea" id="RHEA-COMP:12695"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133356"/>
            <dbReference type="ChEBI" id="CHEBI:133358"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-terminal L-methionyl-L-aspartyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50480"/>
            <dbReference type="Rhea" id="RHEA-COMP:12692"/>
            <dbReference type="Rhea" id="RHEA-COMP:12693"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133045"/>
            <dbReference type="ChEBI" id="CHEBI:133063"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N-terminal L-methionyl-L-glutaminyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50492"/>
            <dbReference type="Rhea" id="RHEA-COMP:12698"/>
            <dbReference type="Rhea" id="RHEA-COMP:12699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133361"/>
            <dbReference type="ChEBI" id="CHEBI:133362"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N-terminal L-methionyl-L-glutamyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50488"/>
            <dbReference type="Rhea" id="RHEA-COMP:12696"/>
            <dbReference type="Rhea" id="RHEA-COMP:12697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133359"/>
            <dbReference type="ChEBI" id="CHEBI:133360"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.254" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022105322.1">
        <property type="nucleotide sequence ID" value="XM_022249630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJW7"/>
    <dbReference type="GeneID" id="110987155"/>
    <dbReference type="KEGG" id="aplc:110987155"/>
    <dbReference type="CTD" id="51126"/>
    <dbReference type="OMA" id="EQHPSMR"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000015">
        <property type="entry name" value="N-alpha-acetyltransferase 20 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="21">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022105322.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20090" checksum="12BEF3D12F476B2D" modified="2022-01-19" version="1">MTTVRPFTCEDLFKFNNVNLDPLTETYGAAFYLQYLAHWPEYFQVCESASGKIMGYIMGKSEGSIPQETWHGHVTAVTVAPEFRRLGLAAKMMNFLEEVSEKKACFFVDLFVRVSNEVAVTMYKGLGYTVYRRVIEYYSGDPDEDAFDMRKALSRDKDKKSVIPLKDPVYPEDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKE3</accession>
    <name>A0A8B7ZKE3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Epoxide hydrolase 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10" type="primary">LOC110986319</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103784.1">
        <property type="nucleotide sequence ID" value="XM_022248092.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103785.1">
        <property type="nucleotide sequence ID" value="XM_022248093.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103786.1">
        <property type="nucleotide sequence ID" value="XM_022248094.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103787.1">
        <property type="nucleotide sequence ID" value="XM_022248095.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103788.1">
        <property type="nucleotide sequence ID" value="XM_022248096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKE3"/>
    <dbReference type="GeneID" id="110986319"/>
    <dbReference type="KEGG" id="aplc:110986319"/>
    <dbReference type="OMA" id="CHGFPGL"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="84"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022103784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022103786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022103787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103788.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38874" checksum="E2DB2102C6BDBE80" modified="2022-01-19" version="1">MAPGIISKLIAFAFTLTYALLSASMVLFGIFMKIIKKGPKGVFSCKTRDTRPPCMDNPDLGTHGFLRIKDVRLHYVSAGDETKPLMLMLHGFPECWYSWRYQITEFKKTYRVVAIDQRGYGDSDIPSGVANYSLKKLVEDIKEVVSGLGYNSCTLVAHDWGGLVAWYVAATYPDIVDKLIVMNIPHPRCFTDSVEGGNLKQLLASWYMFFFQLPFLPELNGWINDYGLISGCFLGDGMGLQNKENMSKEDLEAFKYSASRKGSLTGMINYYRAAFRYRVGIKSSMSTPTLIIWGDQDKALTLKLLDGTGKYVQDLTIKIVPGASHWVQQDAPEAVNKHMREFLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKN8</accession>
    <name>A0A8B7ZKN8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho GTPase-activating protein 24-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110986348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103881.1">
        <property type="nucleotide sequence ID" value="XM_022248189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKN8"/>
    <dbReference type="GeneID" id="110986348"/>
    <dbReference type="KEGG" id="aplc:110986348"/>
    <dbReference type="OMA" id="KEHHIAT"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF24">
        <property type="entry name" value="RHO-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="34"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="152"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="495"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="564"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="445"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103881.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="70397" checksum="80BEC2010FE4DA64" modified="2022-01-19" version="1">MFLWTRFVNRTHHVHESYPHRRMTDRSFSLSREDVTHTGWLKKQGGPFKSWQRRYFVLQGEYLHYFLREDDPRPLGSIPLRNNRVEKRQVNLDEPGKLLFEILPGSDGPSRLTPNHETFLLWAPSQQEVDEWMQVLRRAIYKQKGGGIFGQSLLDTITNESTTSTKQIPSIVEQCVEQLRERGLQEEGIFRLPGRVSLIKELQERFDCGEKPDFKASNTDIHTIASLLKLYLRLLPEPLIPWQHYENFYNGIKLYCDHEEEGKKELIRQLALLPRTNYNLLKYLCEFLHDVQSYESQNRMSMLNLATVFGPNIFRPPLENATSLMETTSMSQKFLHLLIRQHEEMFPPNDQIDFRTKGSSPTPPPRKTGRNITSSPESLDLLKELKDKVANAPVPAPRDKKDRVNYENLLIDLDSDWIKVPSDTGLGKRSYSVDGAFGFHDDTSLSDSSTLESSSEHLCGNSEANSKNTSQIDLDATITPASPNTLHFSNQEALSSLERPLPSPLLPGSGKPQTSEINSTSMGVDLTAGTPENATLNPPSNISSSHLKLLEENAALKLDMRTRQEEYEQKLVKWKIKCEGLEIQLRNEEAAKKATEERNKQLLKQLNAFIAEYGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZL74</accession>
    <name>A0A8B7ZL74_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110986484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110986484</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104071.1">
        <property type="nucleotide sequence ID" value="XM_022248379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZL74"/>
    <dbReference type="GeneID" id="110986484"/>
    <dbReference type="KEGG" id="aplc:110986484"/>
    <dbReference type="OMA" id="HFYCNTC"/>
    <dbReference type="OrthoDB" id="264520at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022104071.1"/>
        </source>
    </evidence>
    <sequence length="749" mass="83882" checksum="FAFD9AE8FDF762F9" modified="2022-01-19" version="1">MAGVTIESVLERISQGHLDCPICSNRFKQPKILECLHSFCTHCLEDLCQAGDPNSPALVCPTCRKETRLSKDGVSALRNNFPLTALVEEFNKQEELLRVLKAKDKREQCNSKEEVVSKCTDCDHFMCVKCKQTHEQLESTRGYKVVATSDVLTGTRITQETPRSNEHDETRCENHGDLVHFYCNTCDLLICTTCTVLDHCCPEHDFVDISLAEETCKQEVQVLLHEVEHCKREIQDALELTEIALCRLKATASQAVSEITDMANREVDRVRQREIMLKKKVAEIDQERSAQLEKSLVGYCGQLQRADKTVHRIHELLEAGNSLKILSQKQGILSTLKNVAGEHSPPKLDELVFETFDFHAKEVPHTFGQFVLSKWKLRAEFGAEAGKVNSFLMVQEINIFANGDIVTVDADQNKVSVHDSNGHFKYHFGGKADKSEQSLNVPSRISVSHPDNRLFLVDGRVVKVFNSEQAYLYSFTPSMHKMHSEYEAGLYKSTDDTRHTGERTAELSRECTEARSPNRVASANKEMEGASETRPELVAEVGSDLKTEVGCYVGEDVDMRLENVQSQATSDVQPEAPSKCMYCYALSCLAISENIVAIGDEESKMISLHSLDGSLIRTLPANLIEDNLAINDSKELVFTNYQESRLESMDLYGNKVFSVTTTHRGKLVKPTGVCCEGRWSIYLGLGRGTGEIHHYDNEGRKVGCIIQQLCNPLGLALTPASELAVADKNSIKIFQKVKCYTEINHVTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLT3</accession>
    <name>A0A8B7ZLT3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110987799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106573.1">
        <property type="nucleotide sequence ID" value="XM_022250881.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106574.1">
        <property type="nucleotide sequence ID" value="XM_022250882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLT3"/>
    <dbReference type="GeneID" id="110987799"/>
    <dbReference type="KEGG" id="aplc:110987799"/>
    <dbReference type="OMA" id="YPTTGWQ"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="459"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022106573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022106574.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="57184" checksum="71CFDAA9B279AF78" modified="2022-01-19" version="1">MRTLVPTSTTAMSVKDYRDVMTDPTKNLLNVMRTNSFTRIKSALTVPGIHFGSRDPEHDLQTLLMRVCRLDMPPRNRRDLAKILLDKQQLDVNAKDSEGMTALAHACMMGDTTMLKLLAEEADVDPNIADREGDTPLLHACRAGQDDLVATLLTHFVRCGLQVDQSNNQGVTPLIEAARGGHADICRRLVTIGNADVNARDGDTFNTAQDYAIASRRLSTPDILLLSPIAQRKLQARKKREAMGRSSLCELMKRASFYPTTGWQQEDSGNTFVIEHRDGKLKQRSKAVTATLHQEHLQQLNSTVFQVAKYGLSRVAEQRQEEDELSADTEKPRQRKISLSLPDLREEDLDQDIKLTSTRSNPLSKSSSQDNHLRVPHRPSPSNSPILSRRSTPSPSRLPHPPVSPSKLHNPRLKLPFVDSPSQSPASVRRRGSVPNKVSMGSKPVVRMNAIHHSSMGLSQSPPNSWAPSANSRSSHAHGQVPVVHIVTPNKNVESRTRLSWEGKPSSSVPSYLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZME3</accession>
    <name>A0A8B7ZME3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987933</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106788.1">
        <property type="nucleotide sequence ID" value="XM_022251096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZME3"/>
    <dbReference type="GeneID" id="110987933"/>
    <dbReference type="KEGG" id="aplc:110987933"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106788.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24363" checksum="1A5EF948B7F433E6" modified="2022-01-19" version="1">MTPLPSPFEGKYGYIRYRAKATVSLIRTFSNKDYKCEKLFSMTGPTLDLNQHPTTQSEVQHRKEMIGCCGCGCSPESIITAGLPKKGFVPGEGIYVIGHVDNQDGDETRMFKAGLFQIVGSSGFFAKFNVVIGTVPHRTVTRPPAAVASALPTDDTGIELSGPTNGPPAPPYEPPPPSYEEAVGVIDRLTRQGNSDDCFSQDQFVPRYPYFNLTVDVPPAHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP17</accession>
    <name>A0A8B7ZP17_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prostatic acid phosphatase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110988281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107333.1">
        <property type="nucleotide sequence ID" value="XM_022251641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP17"/>
    <dbReference type="GeneID" id="110988281"/>
    <dbReference type="KEGG" id="aplc:110988281"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF210">
        <property type="entry name" value="ACID PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034297978" evidence="3">
        <location>
            <begin position="24"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022107333.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50952" checksum="B871A825D1B02742" modified="2022-01-19" version="1">MAAPIVLVAGVLTAFSLFDSASSSGRTLKLTHVIFRHGNRSPIQAYPTDPYQEDSWPQGFGQLTQEGMRQHYDLGQWFRQRYVTDKKLLNSSYIRAEIKVRSTAYDRTLMSAQSNLAGLYPPEGWQVWKEQLAWQPIPIFTEPLTNNFLLVTDDFACPRLKELRAKLEKWHNEYISKNQTFFNYLAEHAGFDPNNVTYYNFTRIADSMQFELADGRTLPLWATKKVLNRLLPLQDFSYSSEAQLSDEYFRLCSGGFVSEIVTHLKDKIAGTDSTKMYMYSAHDDNVAWALRCLNVFNNLMPPTASCLLIELYQEGDKSYTVDVLFKNNTKEEPLKLRLPGTSGQCTVDHFFNITQRFLLTDVSAACKAQKSSYGRSGFLPKTWNTGWILVVCASLLAVVIAIAMVIVLFIGTRRRKLLLKARRMQPISFRLLGHVGTDSEDESVFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPK2</accession>
    <name>A0A8B7ZPK2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WASH complex subunit 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110987166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WASH1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105341.1">
        <property type="nucleotide sequence ID" value="XM_022249649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPK2"/>
    <dbReference type="GeneID" id="110987166"/>
    <dbReference type="KEGG" id="aplc:110987166"/>
    <dbReference type="CTD" id="100287171"/>
    <dbReference type="OMA" id="SMDSPYE"/>
    <dbReference type="OrthoDB" id="307871at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028290">
        <property type="entry name" value="WASH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021854">
        <property type="entry name" value="WASH1_WAHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331">
        <property type="entry name" value="CXYORF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331:SF1">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11945">
        <property type="entry name" value="WASH_WAHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00049">
        <property type="entry name" value="WILMSTUMOUR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WASH1 WAHD" evidence="4">
        <location>
            <begin position="4"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105341.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="50869" checksum="81BD1CAA35CA7228" modified="2022-01-19" version="1">MPVQVYNIPIIQPDLRREETIQQIADTLEYMEKVANEVFDSIITQVSENHTRLEGINKRIDVAQAKVEKIKGSRKAIKVFSSAKYPAPDSHQAYSSVYTDSAMGQVRRPHRKLNSKHQNLDSRALREKLQFYNVQLNIRKDKDGQSSWEGLGGLPKHVESINSLLLFNTSENPYKKYTMIDPLGAVTKTRKAIEEEQEEIGAAPMSITQREQMERQGMENYFYVPDLGDVPEIDVPHYLPDLPGVADDLSYSADLGPSIAPSLPGSNVPELPNVVPGPGGMEALSSTPAQDLPALPAPMDSIGGPPPPPPPGGAVAPPPPPPPPPPPPPPGVEGGGGPPPPPPPPPPGGPDAPSSAPPQQDGRASLMESIRMAGGSGKAKLRNVTERKMEKKQKKQSQAVTGVSLMDDLAAKLSMRRKGISGSRQGSGGGGGASEESKVNGNAGSTMDKLSAMIPPPPKPTRNRSDTANSEDDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPT4</accession>
    <name>A0A8B7ZPT4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LOW QUALITY PROTEIN: uncharacterized protein LOC110987998</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110987998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106915.1">
        <property type="nucleotide sequence ID" value="XM_022251223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987998"/>
    <dbReference type="KEGG" id="aplc:110987998"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="6">
        <location>
            <begin position="43"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022106915.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26984" checksum="82A155FA2ABF39BE" modified="2022-01-19" version="1">MKLLIGARNFYVRFSTRFGYEFALPQSPQMYKQLLMGAGYSSYYQIARCFRDENLRLNRQPEFTQLDLEMAFARSEDVISVVEDLLVYAFQKSQLFSLQSSFPRLTXEEAXNKYGTDAPDLRFDLYLKDFSHLLYDLVLNGCEIGSGGERIYESELQRNILKKLNLSSRKIEKDFGFFLQALEYGFPPHAGFALGIDRLIMILTNAKSIRDVIAFPKTLNFNCLMTQTPVKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQR5</accession>
    <name>A0A8B7ZQR5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Interleukin-1 receptor-associated kinase 1-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110988210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IRAK1BP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107220.1">
        <property type="nucleotide sequence ID" value="XM_022251528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQR5"/>
    <dbReference type="GeneID" id="110988210"/>
    <dbReference type="KEGG" id="aplc:110988210"/>
    <dbReference type="CTD" id="134728"/>
    <dbReference type="OMA" id="TQTATRE"/>
    <dbReference type="OrthoDB" id="6365554at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.170">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2970">
        <property type="entry name" value="Protein of unknown function (DUF541), domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030312">
        <property type="entry name" value="IRAK1BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="SIMPL/DUF541"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18842">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18842:SF2">
        <property type="entry name" value="INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022107220.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27033" checksum="80F04F2BBFC84C00" modified="2022-01-19" version="1">MAFQPSQVFASFSPQANEVKHTLGGASKGQKLLREIQVSSTGEATRAPDRATVRVVVNSTKEAIVDAKTSTTRRLDYIIQTLHTHSVKEGDVTISKFIQRVEGVYSMEAEVTIVFVDFTKCQSVCNFLTEKLDESVRVYPPHFYHSAHNLEAVRRQACLNAVQNARQKALEVARLLRQALGRPLTIREEETSEVEGSSRDASNGHDGALTFQQRMASATFTVTTKVFAQFELVSREKGKQLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRS3</accession>
    <name>A0A8B7ZRS3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110988504 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110988504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107767.1">
        <property type="nucleotide sequence ID" value="XM_022252075.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107768.1">
        <property type="nucleotide sequence ID" value="XM_022252076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRS3"/>
    <dbReference type="GeneID" id="110988504"/>
    <dbReference type="KEGG" id="aplc:110988504"/>
    <dbReference type="OMA" id="RICKVEA"/>
    <dbReference type="OrthoDB" id="6107088at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="608"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022107768.1"/>
        </source>
    </evidence>
    <sequence length="657" mass="71061" checksum="408DE8F635D48CF4" modified="2022-01-19" version="1">MNNTSGRTAPKMKSVQLSADLPPADSHIMLTYNSLPARPHRAMPRNKTGIYLGSDVPPNSPRMYHTVPPLARPRGTLFRPRTPTDKRRRAYAEPGQAGLEQGDRQGLLQVSIRPVQLTDDPDCLSTPLLYLYKHPCPAPMALPYAPPMILRLPILRPKQQQRVEALRVREEPRGFHPQPVRKAKPKVKQDDSQSLTPNNDQAPVLRKSARNFVAAANSGVTHLEDLGLEELSLRSVSTGRESSIPPSIVEDIQNTNRRMVGLEECYSKICKGNLSSLQSLLPARKAAGATTGIRTKTVATPLTIRSFRNPRSPHSVVQYSDLRHKSKGTGAAKPPVPAPYYYSSKGLPNTTDDGGSKVRLTRLPASSRSTERVLAAPGVGTISQSALSRRAASLPSDPPPGIEGIPPPSLNSNAKFMDSEDHYAHKDGFRVPSGTPAVSATDLHKMGSSSSLSDGRKNSSPQNPRHPVSSEAQPTVAPPASPASTRKFDPSTASNKNNSHSIPTGLTNGHGSASESASDLDEPRPDPFSARSEEGSSRSSTLTQGDAPGDTQGDTQRGRLSLSSVTIVVSVENDSGESHVVDLEETVETEYEGDSQAGTSNEDSEQLIHEWQEASEKKHAELQRLLEEHQEIVSHIEELEKMTEQAGGSSREAEQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRY0</accession>
    <name>A0A8B7ZRY0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Persulfide dioxygenase ETHE1, mitochondrial</fullName>
            <ecNumber evidence="13">1.13.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sulfur dioxygenase ETHE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110988524</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12981"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="EC" id="1.13.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Monomer. Interacts with TST. May interact with RELA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.18" evidence="13"/>
    <dbReference type="RefSeq" id="XP_022107822.1">
        <property type="nucleotide sequence ID" value="XM_022252130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRY0"/>
    <dbReference type="GeneID" id="110988524"/>
    <dbReference type="KEGG" id="aplc:110988524"/>
    <dbReference type="CTD" id="23474"/>
    <dbReference type="OMA" id="VMDIDYA"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000013">
        <property type="entry name" value="Persulfide dioxygenase ETHE1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="16">
        <location>
            <begin position="83"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022107822.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34436" checksum="2A455C932AA2966E" modified="2022-01-19" version="1">MNVIPRCLHTVRRLSGLCPAVVLSASAHRPVRFFPARCHSWKLTCRSIPKPRPTHPTGVRCMSSTVQIPSDLLFRQLFDYQSYTYTYLLADRQTKEAILIDPVLELVNRDAHLLEDLQLSLKFAVNTHCHADHITGTGELKKRFPGCRSVISEQSGAKADVYITEGDKVAFGSKVLEVLSTPGHTNGCLTFVLHHNERPVLVFTGDALLIRGCGRTDFQEGSSATLYESVHRKILSMPLDTPLYPAHDYTGQTSTTVGEEKMYNARLTKTKEEFIDIMEKLNLPYPKAIDKSLPANMVCGVLEDLPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZT19</accession>
    <name>A0A8B7ZT19_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tigger transposable element-derived protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108728.1">
        <property type="nucleotide sequence ID" value="XM_022253036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZT19"/>
    <dbReference type="GeneID" id="110988997"/>
    <dbReference type="KEGG" id="aplc:110988997"/>
    <dbReference type="OMA" id="AMYWINS"/>
    <dbReference type="OrthoDB" id="10056141at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004875">
        <property type="entry name" value="DDE_SF_endonuclease_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF73">
        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03184">
        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE-1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108728.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="38038" checksum="9BBE9CFB95378280" modified="2022-01-19" version="1">MPWRKAKQRACHRPALCQHGWVREIETKFNKPRCFKNVAYLPLSYRANRKLWMVSDLLNQWVCHLDKKFTRQKRKVLLFVDNCAAHPKVPHLKYITLQFLPPNTTSQLQPMDQGVIRNMKVHYRRKLPQTLLSAYDAGETPQPVNILETINMVHTAWGAFEQDCIANCFRKAGFIDTTPRSPPPHQDQDQAQDQDQDQDQDQHGRPDNIWERLTQHINLPVTFQDYASVDMDLQVTDEPSEEEIVAEITSERASNDGNDFEEAEAMEAARAQTQQLTVRQCISMMTQVQHFICTWSNMTDGIYISAANIMNYLSEEQHGATIQGKITDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUZ4</accession>
    <name>A0A8B7ZUZ4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-amylase</fullName>
            <ecNumber evidence="5 13">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110988927</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="5 13"/>
    <dbReference type="RefSeq" id="XP_022108600.1">
        <property type="nucleotide sequence ID" value="XM_022252908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUZ4"/>
    <dbReference type="GeneID" id="110988927"/>
    <dbReference type="KEGG" id="aplc:110988927"/>
    <dbReference type="OMA" id="NACTINE"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="15">
        <location>
            <begin position="4"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="14">
        <location>
            <begin position="374"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022108600.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="52733" checksum="52712275C59653B7" modified="2022-01-19" version="1">MQCNVYSRYLGPHGFGGVQISPPNEHRAIWQPWRPWWERYQPVSYKLTSRSGNEQQLRNMIQRCNDAGVRIYADAVINHMARGDSGYGIAQSWYDVEVLSYPGVPYTSSHFGSPNGECRSDSGNVEDFTDISQIRNCRLEGLPDLDASHDDVKSRITAYMNRLIDMGVAGFRVDAAKFIWPHDLGEILAKLKNLNETFFPRGSRPFIFQEVTNKGVNGKMWGQEYVAYGRVTEFKYGLKLGQAFSNPGNLSNIEILIGSLDMLPDSLALVFVDNHDNQRGHGGGQGVITFKEPRQYKMCNVFMLAYPYGITRIMSSFDFNDTEAGPPSDMKGHTLTVTVNKNGACEEGWVCEHRWRSIKNMVGFRNIAAGQPLTNWWNNGNRQIAFGRGDKAFVVINNEDYPLLQTLKTGLPSGEYCNIILGDFDPSMGLCSGPTIHIDGSSNAFFRVGTGNDSTAAIHVGAKVSKSGTRYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV62</accession>
    <name>A0A8B7ZV62_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110989393</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110989393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109448.1">
        <property type="nucleotide sequence ID" value="XM_022253756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV62"/>
    <dbReference type="GeneID" id="110989393"/>
    <dbReference type="KEGG" id="aplc:110989393"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022109448.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="22566" checksum="0CC5C3C0166FEEF3" modified="2022-01-19" version="1">MLYHKECDYQRLEVAMDVNFSTYLSGFNGFGGSFNLQVLANDIGLHQEYRKALRSGSLPCNRLRILTIGDKGVGKSSTLKYLCGEVCDPNAELQATEGTDITIGETCEQEPNWKHCNTGVCKSADDPGLCAAWCVCKGIDIMGGVLNSVKDDTLSEDEHGVLIKSPQSRGHNQDRGTTERDVGKAFQRMPVRMTSNSSNACASGCSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWQ5</accession>
    <name>A0A8B7ZWQ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Piwi-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15" type="primary">LOC110989256</name>
    </gene>
    <organism evidence="11 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109192.1">
        <property type="nucleotide sequence ID" value="XM_022253500.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109193.1">
        <property type="nucleotide sequence ID" value="XM_022253501.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109194.1">
        <property type="nucleotide sequence ID" value="XM_022253502.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109195.1">
        <property type="nucleotide sequence ID" value="XM_022253503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWQ5"/>
    <dbReference type="GeneID" id="110989256"/>
    <dbReference type="KEGG" id="aplc:110989256"/>
    <dbReference type="OMA" id="IVHYHVD"/>
    <dbReference type="OrthoDB" id="445936at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000014">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="PAZ" evidence="9">
        <location>
            <begin position="308"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="10">
        <location>
            <begin position="583"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022109192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022109193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022109194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022109195.1"/>
        </source>
    </evidence>
    <sequence length="890" mass="100618" checksum="C90CA7796F8F4CF4" modified="2022-01-19" version="1">MADNQQASGSGRARGRGRGRGRASQQHVQPRRPGEPAGAATAMPKPLGDPDTVPAPGRGRSRGGASQIPGSGAAISSEQKAGATVPLAEPPTTQMAALSMGQVQGAEGGGVSARRGGFLEEELKTRPEHLTDKRGKKGKTVELLTNCFRLRADGQWLLYQYDVKFSPEVDSRRARHALLRSHSEIVDGPMAFDGMILFLLRRLDQPVTRFETKRRDSDAVVTITITLTSELPPNSPTYLQVYNIIFRKILRLVGFEQIGRNYFNPELKIDIQQHKLQLWPGFITSILQYEEEVLLMADVSHKILRTETVLDLIYHLSQTKEDWADKFKTLITGEIVLTKYNNKTYRVDDVVFDKNPLDAFEKFDGTTITYAEYYRDAYEVELRDFKQPLLVGKRKKRDERQGATNIHLIPELCTITGLSDNMRSDFHVMRDLATITRITPNDRLQQLSSFLGSFPKNKEAYSHLRRWQLNFDPQPVRINARIMDRETIITGDRGSTRITLDENAEWSRQMRKELLNSVGLLDWMLIYIGRDSKNAMDFLTSLNRVAPNLGMEVRTPLKCELRDDRTESFIRAIRDNLTPRTQMVVCILPTSRKDRYDAIKKLCCLEAPVPSQCIVSRTISKKQTIMSVATKIAMQVNCKMGGELWTVEIPSKMLMMVVGIDSYHDLKNKEQSVGGFVASMNHSLTRYYSRCTFQHSGQELIDSLKVCMTSALKNFHEINGSLPERVIIYRDGVGDGQLAAVVNYELPQLLSTFQMIGKNYKPKGAMVVVKKRINNRFFSLKGGQLQNPSPGTVIDSGVTKPEFYDFFLVSQSVRQGTVTPTSYNVIWDVSGLAPDHIQSLTYKLTHLYFNWPGTIRVPAPCLYAHKLAFLVGQSLHREPRIELADRLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWS4</accession>
    <name>A0A8B7ZWS4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110989726</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109998.1">
        <property type="nucleotide sequence ID" value="XM_022254306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWS4"/>
    <dbReference type="GeneID" id="110989726"/>
    <dbReference type="KEGG" id="aplc:110989726"/>
    <dbReference type="OMA" id="PAMQDEF"/>
    <dbReference type="OrthoDB" id="5952569at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="499"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109998.1"/>
        </source>
    </evidence>
    <sequence length="565" mass="64613" checksum="7A7ADF8CBC389EB7" modified="2022-01-19" version="1">MGAGASREQEKSKPQNLVESYKRDVTKALEKYKVLRDLDIFVLDNSIRESTVGQLRGHTLESKWQIYDEVKKCGFKHTIVASFSHMTRVDDVFIMQLKEKGEDPDGLWAFSEITAGTKGKVPDTENVPVGIQKLKPAGLYCVIFEVDLGDIVYDFNKFAVKDMCALLNKWNDWCFENLSPKAKVMVSFRDLPDVMPDHSERVFETVAYLARLPPNRRPFGLMFEEPRGKSLPEECGMWTRYIREVMNKHSWGGHLLVHVHEKFGYCDATALQVLMDGADGIWASVCAEGASMGNASSCVTLMNLIRLGNKKVLQKYNCTYLRKAAINVTKITTGKDPHIKQPVFGARAIDFVFDLKPEEFDLASFFGEKAPIRITTMASKEMIRQRLIDLFGEDPQFTLQVAHEMKELILEDLRTGRKEEYMSMVGLALLFDRAGGSLNQKMRDAIDEFELKGPHAENLLAEVRKTWDEWDLKDKVQGDNMLQFDSFYNGFMAPYFSCYRCSDTMKALQAIDMDADGMVDWNEFETYLKWALHQYPNIADVQELLDVAFRKGLIPAMQDEFLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX00</accession>
    <name>A0A8B7ZX00_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110989684</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109939.1">
        <property type="nucleotide sequence ID" value="XM_022254247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX00"/>
    <dbReference type="GeneID" id="110989684"/>
    <dbReference type="KEGG" id="aplc:110989684"/>
    <dbReference type="OMA" id="IHMTIAG"/>
    <dbReference type="OrthoDB" id="10260741at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109939.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31276" checksum="EF383D483001A8FF" modified="2022-01-19" version="1">MASSKPAKVIATRPREQKSPTRKTPTEMARKPSSSILKNSQSERKVSVAASARKVSVASSSSSGRKVSVTTKARNLPGTLTRKTSNCSDRFIGGHSGPAPSLLQRPPAASSSVVGFRQLLVTKRLARNLKLRTAQRMAERRGRSFITYSDRPGRRRPSPGQDVLVEPSYQVRPPQKFGEFQGAISDILEELIPETLSRMPYDALVCSRQAKSLAGDIQERVKDLRIARYKLITVVHIGEIQQQAIRVCSRGIWDVEVDSFVTYQYQNASLYCVATVFGIYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXB1</accession>
    <name>A0A8B7ZXB1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Uncharacterized protein LOC110989835</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110989835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110183.1">
        <property type="nucleotide sequence ID" value="XM_022254491.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110184.1">
        <property type="nucleotide sequence ID" value="XM_022254492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXB1"/>
    <dbReference type="GeneID" id="110989835"/>
    <dbReference type="KEGG" id="aplc:110989835"/>
    <dbReference type="OMA" id="KERYWAY"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665787" evidence="5">
        <location>
            <begin position="36"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="139"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="249"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="534"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="644"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="890"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022110183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110184.1"/>
        </source>
    </evidence>
    <sequence length="951" mass="107348" checksum="66872F79C495D4E9" modified="2022-01-19" version="1">MSGDLQTTNTAARMTYKTYAAVLILLAKICASADANPPEVWNVSITTSPEGPVLEGSNVTLTCAVNSDPPSGGWLELQHRFWYRTTTVSDTIYAATSHNFELEGVLRNQTGLYRCNGRQNFEQWFRSSNWTSVMVHYRPTIINKYRTWIGAEETYTATLECVIQGNPQPMVIWYGLNGTIITATNGSELSLNDVISGDGVFGYLVKSRLTIDSVRPSKDYGMYRCRASNNIGPYDEHEIQLTKTGKPEPPRNLEMVYVSRTRIRVTFEPGYDGGETLQSVFANIREIPGEFDPSDWNRLSRNSTSLLFDYLERGTVYQIALYAINVHGSSTYAKMIVWTDHTELHSLGIDVSYSRAKERFVITGIPQDNDTATCLRIAGYNYGMRRWMSLGSDLDCIQHDGEFPYSGPFIRMKCEYCRDNRCTYSKRIYDWDVTMTITPPGPVVEGTEVQLTCIINREELYIKLTLWQFSRDQISSTNLNRPTYERPYTTLSLGDAYRNQSGWYRCAWTRYSTPSNWKPSAYSDWTAVTVFYRPEITIEGRTWIGVNENQSATFECVILGNPLPKVTWYGANGIAISNNTDPGRVYLEDTITGDDFAGFLIKSKVTIFPVQSTDYGIYTCRAANNISQYDEYEIQLNKTGKPEAPKNLRAYYFAENGIRVVWAPGYDGGETVEFNYINIRMIPQEFDPLGWNELNPDSPRGNFSDLKLDTLYQVAVYAKNRHGSGPYATVEKHTKPNAPSVMGITVSYNVAERTLFVAGMPEGNNTGTCLQLTGYDVERIKWVSLRPDLDCVQHDGEFQYSGQYGGHMHCRYCRDGVCGKESHITEVHPSTTLAPQSAQTTRASGRNGEATWPIILASCCSCVLVVAFIAFCNRLRLCCVKITSSEECAEHTTQPNTTVEEAHPLRDPPPSYLETTEMQVIADDSDDPPPTYEWASWSLQQQTRDGEEHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYY1</accession>
    <name>A0A8B7ZYY1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cysteine-rich with EGF-like domain protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110990172</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Protein disulfide isomerase. Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CRELD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022110728.1">
        <property type="nucleotide sequence ID" value="XM_022255036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYY1"/>
    <dbReference type="GeneID" id="110990172"/>
    <dbReference type="KEGG" id="aplc:110990172"/>
    <dbReference type="OMA" id="HCRANQY"/>
    <dbReference type="OrthoDB" id="19903at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.20.10">
        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF148">
        <property type="entry name" value="RE58433P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034804671" description="protein disulfide-isomerase" evidence="19">
        <location>
            <begin position="24"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="143"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="341"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022110728.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="46601" checksum="87B133F1860CF1A6" modified="2022-01-19" version="1">MLPTKSAISIVSIVFLLFVSGSAANKKKNEEVQKKCDTCRALVKSFQEGMERTARYNFAGGDTDWEEKKLGKYSTSETRLIEIVEQLCSKDEHECNRLLEDHEEQLETWWKEHQTDQPDLLQWLCIDALLICCPDNRYGPECQDCPGGLERPCKGNGKCSGGGTRAGTGKCKCSGGYKGELCDVCKNGFYTETANETHTVCTACDESCAATCTKGGPTGCKKCKGGYIKDEEKGCQDIDECKQETPPCQSNEFCQNSLGSYQCVACHMACDQCIGEGPESCVKCKSGFKMEETTCKDIDECETDETCKKDHMFCKNVPGSFLCECEEGYLQITDGCVPKSVLDGKGSPPQPSMSLKDGDVPPAEETDQEADSTTAKGGEADSVGVESQSRATGGNESNSEKQNDSLNKNELRHEGRDSSEQNRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0B6</accession>
    <name>A0A8B8A0B6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Carbamoyl phosphate synthase arginine-specific large chain</fullName>
            <ecNumber evidence="13">6.3.4.16</ecNumber>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22 23" type="primary">LOC110989285</name>
    </gene>
    <organism evidence="20 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22 23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="13"/>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022109258.1">
        <property type="nucleotide sequence ID" value="XM_022253566.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109266.1">
        <property type="nucleotide sequence ID" value="XM_022253574.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109276.1">
        <property type="nucleotide sequence ID" value="XM_022253584.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989285"/>
    <dbReference type="KEGG" id="aplc:110989285"/>
    <dbReference type="CTD" id="1373"/>
    <dbReference type="OMA" id="FPFNKFP"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000012">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000006">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000026">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="548"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="18">
        <location>
            <begin position="1088"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="19">
        <location>
            <begin position="1350"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022109258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022109266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022109276.1"/>
        </source>
    </evidence>
    <sequence length="1499" mass="165620" checksum="6E9350FAE385194B" modified="2022-01-19" version="1">MAHLTRVASALKHQVGPQLGSLRLRLLSTSSSAWANLDKPRQAYLVLDDGSKFKGYSFGHETSVTGEMVFNTGLVGYPESMTDPSYRGQILTLTYPLVGNYGVPDTNIEDENGLRIHAESEKIQITGLLVQDYSKRPSHWASVKSLSDWLTEEGVPALYGIDTRMLTKKIRDTGTILGKIEFDDQPIDFVDHNARNLISEVSTTETQIFGKGNPYKVIAIDYGIKNNIIRSLVKRGAEVHLVPWDYDVTKDTYDGLFLSNGPGDPALANAAIENLRKVIEEDKPKPVFGICMGNQLTALAAGAKSYKLALGNRGHNQPVLNMINGQAFITSQNHGYAIDEATLPKEWKPIFVNANDHSNEGIMHESKPIFTAQFHPEHKGGPTDTEFMFDTFMELVRTGHSNIKTAISPVVPLPERPVVSKVLVLGSGGLSIGQAGEFDYAGSQAVKALKEENIQTVLMNPNIASVQTNEYGEKQADNVYFVPITPEYVIDVIKREKPDGILLSMGGQTALNCGVELFKQGIFKEHGVEVLGTSIESIMATEDRQTFNDKLKEIGEKIAPSFAVETVEEAFQAAEKIGYPVMVRAAYALGGLGSGVAKDKEKLQQIATQALALSNQLLIEKSLLGWKEVEYEVVRDAANNCITVCNMENFDPLGVHTGDSIVVAPSQTLSNQEYHMLRETALKVVRHLGIIGECNIQYALHPTSLEYCIIEVNARLSRSSALASKATGYPLAFIAAKLALGVPLPQIRNATTQSTTACFEPSLDYIVTKIPRWDLDRFHHTSSVIGSGMKSVGEVMAIGRTFEESFQKALRMTHPSIDGFSPKMPMGKPFPSNLEEEMIVPSSYRIHVIAKALHDGYTVDQIHDLTAIDKWFLHKLKRVTDIDHTLAKLDQNSVSPDMLLKAKKAGFSDLQIGSRLKVDEKEVRNLREKHAVKPWVKQIDTMAAEYPAKTNYLYCSYNGMEHDVTFNDHGTMVLGCGPYHIGSSVEFDWCAVSCIRSLREMGQKTVVVNHNPETVSTDFDECDRLYFEELSRERVLDIYSQEKSTGVIVSVGGQIPNNLALPLWNDGVNILGTSPVQINKAEERSLFSAILDDINVNQAPWRALSSLDEALDFAASVGYPCLLRPSFVLSGSAMNVAYGPDELRNFLAAATMVSQQHPVVITKFVEGAREIEMDAVAQSGKVVAHAITEHVENAGVHSGDATLILPPQTISAEVINKIKEATAKIAKRFEISGPFNTQFLAKDNDIMVIECNLRASRSFPFVSKTINCDFIDVATRVMLREPLDRTMLPTLDNPSIPEGYVGIKAPMFSWPRLRDADPLLRCEMASTGEVACFGPNVNAAFLKALLSTGFKIPKQNILIGIQKKFEPVFLPTAHKLHQMGYKLFATEKTAEYLTEHNIPAKVVAWPLADQHEKIDAPSAIRLIQSKEMDLVINLPNNNTRYIQDNYLIRRSAIDAGVPLMTNFEVVKLFAQALDHVGKLDATTLFHFKKPRHSVMKTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1Q8</accession>
    <name>A0A8B8A1Q8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: galactose-3-O-sulfotransferase 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110990549</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111292.1">
        <property type="nucleotide sequence ID" value="XM_022255600.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990549"/>
    <dbReference type="KEGG" id="aplc:110990549"/>
    <dbReference type="OrthoDB" id="514299at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF87">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022111292.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="31027" checksum="140B7EEBB6E729A7" modified="2022-01-19" version="1">MKLPFCRWRRGTVGTTTAPCQPINRIVFVKTHKLGSSTITTTLQRYGHHKDPNFILPAQKHFFSTNLSSLKRPSLKLRIPVQSNRQEKGNLVWPALGGYHILGNHARHNRPRQDALIPKAXYFTVIRYSVSQLESAFSFYKFGSQMQHHRIEDIFESKAVEFLTNSKSKSGLAFLQNGQMFDLGLEQEDIRMPSLRTRNSSRTKIFSVLAGRIRKWNNTYAKLYRYFNKTFREKVRDYXPDFLLDLKIFRERNAEVSRQCLINTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3A2</accession>
    <name>A0A8B8A3A2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synaptonemal complex protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110991210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022112169.1">
        <property type="nucleotide sequence ID" value="XM_022256477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3A2"/>
    <dbReference type="GeneID" id="110991210"/>
    <dbReference type="KEGG" id="aplc:110991210"/>
    <dbReference type="CTD" id="6847"/>
    <dbReference type="OMA" id="KHKDQYD"/>
    <dbReference type="OrthoDB" id="10064612at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008827">
        <property type="entry name" value="SYCP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46918">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46918:SF1">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05483">
        <property type="entry name" value="SCP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="797"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="854"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="425"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="866"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="909"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022112169.1"/>
        </source>
    </evidence>
    <sequence length="1044" mass="119235" checksum="7F5A7A5394E55A6A" modified="2022-01-19" version="1">MLSSQRQDEVESQPFFKPTTQNQNASNSFFIFGDKETSRSTATSIFQDSSPQPQQISTARPSLLITPSLCPSAATVSNMQERQYQQQQMQKQQEPSDLLDSSDRLSKLHTRLHKEADKIRSWKVQTEMDLKQRERKLQDAQITIESQKKSILELQLQNENLSRKLKEEMDNRTDISERIESTRDMCNLLKDYTTKLQDRMAMCESDRDELKTMEKQNIEDLEELGVMFKDLSLLHTNKVNDLMLALNNEKDSSLKNSEQLISQTREIQLKLKDLERQLDEKEVSIQQMLVKKQEIEQHLAELEKENSSLQKTLAEAVDKVQTQAEVLEQSDKQITDLNHRQEELISEKVQLQEDLQSHSNHIEELEQNVQSLTECIEKLTSEKDTLFLETQTLRENLAIKLGEIDGLKDELKVVLEREQASCEKVDSIKQQNQAEREENVKLSESLKTAEAESKSLEGKLLIKEEQMQELRKNLETLQETAKEGKTMLEASGQKTKDLEEEINILRETHTERELNTAQELHEVKIKNENLNRELEAISNQSISLESKNKSLHGQVTSKTKQVKDLQQELKTLKGKLTAQTKLATAAEEKFSSVSKELEDTKSALEEMKAKLHSATEDMEHEKDVLKDLRTKLLKKEQEVEEKIDIVENLEDQAVSLRQKTEAAVKEHTDAKQACELQMAEVSATLDKYKAENERMVAQKEKEIDQLKKEMEQQKYKKKLEEDQISQMKKDLQGLKHQLAEVQAERDEAKKQVSNQEENIHSLKEKLKGKEDELNQLLTTAESLGEPMAGISPIAPKQITSLPKHSTPKPTPKQVAPQTPTSLMAEKPLPLTPCKSKNPRHSILKHAVSATRKRHVAFASDDEDSFDGSVSDSSSSQLMEIEQSEVDRRLNTTPCARPSQKVQPLHVTPSKRNPSSGQSTPNMSAKMTPLKPGSGGRQTPSKSRPYLKPKKMKPQEEVPSEMTQAELIRFKELYPDETAMHPSNKVKAKKTLLTTGNTRKTSNRIFKVKGLQDSFKGHKTKLKAGKPKENDLSWLDMDAVYGFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3L3</accession>
    <name>A0A8B8A3L3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990736</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111525.1">
        <property type="nucleotide sequence ID" value="XM_022255833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3L3"/>
    <dbReference type="GeneID" id="110990736"/>
    <dbReference type="KEGG" id="aplc:110990736"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111525.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14326" checksum="2EAD626B98A7B217" modified="2022-01-19" version="1">MCQADVFHLDTWVEWDVCHGWYHCLCTGLSHAAAEKMKYQCCSLNCSTSVARLEGCTISVGEIKKVRNEEDLSGDAIDFFMRHLMSNDKHLDLSIFCGPTIPREQLAPNSLLEEAIPWTSQDTFALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A509</accession>
    <name>A0A8B8A509_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110990363</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022111021.1">
        <property type="nucleotide sequence ID" value="XM_022255329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A509"/>
    <dbReference type="GeneID" id="110990363"/>
    <dbReference type="KEGG" id="aplc:110990363"/>
    <dbReference type="CTD" id="25820"/>
    <dbReference type="OMA" id="HRFCMIC"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20343">
        <property type="entry name" value="BRcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16626">
        <property type="entry name" value="RING-HC_RBR_HHARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000002">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="41"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022111021.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="48981" checksum="CC1CA3ACDA1F0569" modified="2022-01-19" version="1">MERFYSEDQDQLFNEAHVVSPYKKQPVRHTSRVATRSSGPVLEPCEICCRNVLSTMMTGLECGHRFCMDCWTEYLTTKIMEEGMGQTISCAAHSCDILVDDYTVMKLVKDAKVKLKYQHLITNSFVECNRLMRWCPAPDCPNAFRASHLEVRPVTCTCGHICCFVCGENWHDPVKCKWLRKWIKKCDDDSETSNWISANTKECPKCHVTIEKDGGCNHMVCRNQNCKADFCWVCLGPWEPHGSSWYNCNRYDEEDAKKARDAQARSRQALERYLFYCNRYMNHMQSLRFENKLYSQIMKKMEDMQQHNMSWIEVQFLKKAVDVLCQCRSTLMYTYVFAFYLKKNNQSLIFEENQKDLENATETLSEYLERDISSDSLADIKQKVQDKTRYCESRRKVLLEHVHEGYEKDLWEYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XEN8</accession>
    <name>A0A8B7XEN8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptotagmin-12-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079219.1">
        <property type="nucleotide sequence ID" value="XM_022223527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XEN8"/>
    <dbReference type="GeneID" id="110973065"/>
    <dbReference type="KEGG" id="aplc:110973065"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000080">
        <property type="entry name" value="Putative synaptotagmin-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF252">
        <property type="entry name" value="SYNAPTOTAGMIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="157"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="288"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022079219.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="46990" checksum="78B2B6FE813897B5" modified="2022-01-19" version="1">MTVIGVALVISGLTAAGVGLAAVWVRFCRSCDLQKLIDYICRRNEERTNLIQTDYGTAYQVDQSTDISAPDDPDSGGFVEYENIFAKAEQAISAAAQESHAHAANLLPDTEQQDGAETSRDGSPDELLMRKLVRCYSSESLSSVTSESSVQENFMNVAGQIEVVMDYSTEQNRFTLTLVQATDLKARDNASPSDTYVKVHLMPEHELKGQTKVYRKSLNPVYNERITIKMAKVDLADHSLKFTVFAYDRHARHEAVGETVLKLGDVDLLPGPFSTWLNLSDINEKPADLGDILFSLSYLPTAERLTVVIVKARGLKWTENKVTADPFVKVYLLQGGKKISKKKSSIKRGDNCPIFNEAMMFAVPSNILDKVTIRITVAENAPGGKIPSIGHVLVGSSCKGANLTHWNQMLTVLRRPIAMWHPLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGL4</accession>
    <name>A0A8B7XGL4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110973409</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110973409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079928.1">
        <property type="nucleotide sequence ID" value="XM_022224236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGL4"/>
    <dbReference type="GeneID" id="110973409"/>
    <dbReference type="KEGG" id="aplc:110973409"/>
    <dbReference type="OMA" id="GGCSHTQ"/>
    <dbReference type="OrthoDB" id="2668416at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022079928.1"/>
        </source>
    </evidence>
    <sequence length="752" mass="82380" checksum="8AF65553F88503CC" modified="2022-01-19" version="1">MPKSNRNCAVGGCSHTQKTCPKGRFVGFPNEEKQPERRALWVKLVQRGSQWVPTKNSRVCGCHFCGGYKVDDPNDPAYNPSIFPPAPELDRRVRKTMMEEMYRQKAQEVQAIVDHPPPLPLPTNQRHENDDLMKYVSAALDLSKEAGEEYAQAVKAEKDALKSNHERINGPLTSTDGAQEADCHQLTSANQESPSRVKTASGVTTSDELDGNCQFISGGQLSAQDELVKDGSLSVDSTHGWLYIKQSRTLGSAVNAACGSHEPGFRKRRLLHASHKPQGPMRLQKSVPTSRKSSGNLSVAKHPRNVQIRHFTRAVGSVDLNRARALNASASPLEQNATTGTQPHNCILSNLLTMHQSKETQTVLSVASLADWNTSSLQTRGRCFGFHGWNDICFSETTVRRVTGVTPEVFDLLLDQLPEVMPGLPSHNCLLLFLMKLKMNVPFEFLATVFGITAPTASNIFSHVLATLVGLLSDLVRWPSGSLEDSLPQESHWRRIPGLRVVIDFLIIQTEWPSPEHQPEMLSKEEGTGAVKILVGLYPNGSIGAVSNAFTCCTTVSDGLANLRLPDFCEKDSRVLLLQQDKHLYRVLRSKGFSVLSPPYTSCTIPWQEDPSSDILTHPHSKGVPRPCNSISTKLSELCEMTEAAAQSDLMELSVPDGSIGNGFLGSVDGLQESVDGLPEPGAPSSTPEPAFCPKSEHTPDTVAFRAYARRMAQRLRSFSILTSMFESSLLPHIDDVVAVCAALNNLQDPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHI6</accession>
    <name>A0A8B7XHI6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly factor 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110973225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in an early step of the mitochondrial complex IV assembly process.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079572.1">
        <property type="nucleotide sequence ID" value="XM_022223880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHI6"/>
    <dbReference type="GeneID" id="110973225"/>
    <dbReference type="KEGG" id="aplc:110973225"/>
    <dbReference type="OMA" id="KKTPKEC"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022079572.1"/>
        </source>
    </evidence>
    <sequence length="80" mass="9364" checksum="4739DB431873AC86" modified="2022-01-19" version="1">MPKYFEDKEESKRPCSGVREDLKTCLLESDCVRIDKKTPKECLQPGTNVNDQCRALQVAFFECKRSLLDTRTRFRGRKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJU8</accession>
    <name>A0A8B7XJU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974058</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081074.1">
        <property type="nucleotide sequence ID" value="XM_022225382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJU8"/>
    <dbReference type="GeneID" id="110974058"/>
    <dbReference type="KEGG" id="aplc:110974058"/>
    <dbReference type="OMA" id="FMVLTQW"/>
    <dbReference type="OrthoDB" id="5950491at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022081074.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="41944" checksum="23296E02EE1C6865" modified="2022-01-19" version="1">MTFLTTTTDGDVGDTELNAGWAVSEIENSMAVRAIYGIIAVLGIAGNFLVCLVLLRVPSLRSQTSNFLVHLALVDLVVCIWAVPFHLFPHAPDPSPGFWGDLKCRLYSSKFPLWTTAQVSICSLVTVNLERYIAIVHPIKYKNIYTPRNTAIMIGTCWAVGIITNSYTFYVYGNDEYGRCSFFGWPTKGFQVVLGLWNFTSYYLAPFAFMVLTQWKVIKTLKVQARTLKEKRERKVSTVRKSDNCKMWQVYAAQELEKTLLIVSVTYAICWAPNQFIFVVFNLSPDPSIVDFGSVYYHITVILAVANSCLNPIIYTMKNRPFRRGIRKVFSCRRLRPKTGSVDITPATGGSDNLRLGHGPGIIVLESTNDASQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKA9</accession>
    <name>A0A8B7XKA9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">WD repeat-containing protein 11-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110973790</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080576.1">
        <property type="nucleotide sequence ID" value="XM_022224884.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080577.1">
        <property type="nucleotide sequence ID" value="XM_022224885.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973790"/>
    <dbReference type="KEGG" id="aplc:110973790"/>
    <dbReference type="CTD" id="55717"/>
    <dbReference type="OrthoDB" id="1291858at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057852">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057853">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057854">
        <property type="entry name" value="TPR_WDR11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039694">
        <property type="entry name" value="WDR11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14593:SF5">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23751">
        <property type="entry name" value="Beta-prop_WDR11_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23752">
        <property type="entry name" value="Beta-prop_WDR11_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23753">
        <property type="entry name" value="TPR_WDR11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDR11 first beta-propeller" evidence="2">
        <location>
            <begin position="16"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 second beta-propeller" evidence="3">
        <location>
            <begin position="527"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="WDR11 TPR" evidence="4">
        <location>
            <begin position="978"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022080576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022080577.1"/>
        </source>
    </evidence>
    <sequence length="1338" mass="149518" checksum="0C31BC85B26A28F0" modified="2022-01-19" version="1">MNIFPRTITGALHGQNKIACDWGWQSLVAYGCHTSVVVVDTKAVQVIQTLEKHKSNVVKVKWARENYHHTIDAPYTLRLATADAGGQIIVWDVKDASDRASFNEGSKPVLDLEWLSTQDASHDLLVALHPPYSIVLWNADTGTKLWKKTFTDNIISMTFDPFDSSNLALLGNDCILFLNDFSITKQPSSNGRKFYITVPGTSGPSPSSSSTNLSGGSDKKIGNRFRRVRLLVGDNKPRNSQLAVEDTDPIALNECLQMTYLQSRRQHLLLVYPREILVLDLDIYQTVGMIPMERSGSPFQQVYPCKQRDVLLCLHENGSISVRVRRRPRPSTSPSTATPVDQIGNFVGLTGGDSFLSHDPHDVIYDLRCQSDPLRVTKHMRAFGLACCMSTERQMALLMSDGRLLIWSLMTVDHAPSSTSNVHTQMVLSPLYSPGIVPGVTNSDFEFLPPLSNSGGHQILPHPKISMADLICQTDVAGDPISTQPQQQGRGVILKFVLTGLSCGVASVPTIIRMCPPVTTRNLHKYKPLAALGSSTGLVQVYNLTTGSLWREYNIHTCSVRGIEWVSLTSFLSYSYPNPPSNGLVRNELLLLDLLTGRTIPLRGHKGDEAPIEAVKVSHLKQYFIVMLKEKPFEIWDLKNRTILREMPANFPIITALEWSPTHHKKRSAMSIQETVGSSSLLDASGSSHILDGSGDSKMSQVTATREHFFFAESNRMLHHFWVEGSLVKEGSRLPSDSGLGSITCMTWKGETLVMGDADGMLGVWDLKARVSRNYPTHRSSIKKVKFAPGKGNLKILCLWSEGLDIWDIKEVRGTSSMKVTKEQTKLIDADWAASDKPIVVSSDGCIRVCDIKLKTTCSPMDYAEFADPVFCPYLLSPKAALAMKYTMQHQPWNDEYTLQLSKEYSTQVKSTLPSEDKRRPHFHEPAWLANLPTAADDDSVIDSVLDSETEEEPERCETPEDENFIKAVNDQFDIMPQKMKDYLPVCPYGTAQRCLLAAQLFGDEAETTFWTVALQYLKAEKARLNCPIHKSTPDNPGAGYHSDPFQGEVPGALPSNNRSLLMDTREEEVVTSCSCIKEPLLDTCYDTLCDSKSYQKYQLERLSLHDSKRSTHEQTMKCAENLILLGQFDRAVQLYLETEAENDSYYLDSILACLVATVKSTGASQSTIKLVATSLIANNKLSEGVQLLCLINKGIDACRYLITYGEWNQAVWLAKATLPFSEYSVVLRRYIDYLCSPAVNQKTKAILVLLSIGQFQQVLEVLMSMHYYDRAGMFAEACTEFDVLPDTEEIRTLLEKVYLEYARYLLALGNRKAYGYYCNKAAEKAQKVNQDLEWMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKB8</accession>
    <name>A0A8B7XKB8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973700</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080400.1">
        <property type="nucleotide sequence ID" value="XM_022224708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKB8"/>
    <dbReference type="GeneID" id="110973700"/>
    <dbReference type="KEGG" id="aplc:110973700"/>
    <dbReference type="OMA" id="WYITETE"/>
    <dbReference type="OrthoDB" id="10362150at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034908340" evidence="1">
        <location>
            <begin position="17"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080400.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27560" checksum="BCFA65EA1A6C184B" modified="2022-01-19" version="1">MYAAVILCILVVAASASPEKFIFGNKLDQPAPEKCCAEPYYTFQADSVFNTLQEGSLLTELIRARGAYDSIDKKFGLKVDLHISNGTVELYQLINDFKEGLGYYIYTEEEETKCVEFPITSGFPYNCIPEGSTYVGSVTIGDRALRAANWYFNDKTDPTKDMHIVFSIKEEECIDLGYLARTFDPETGTEISVDRTGISDYNLGICDPDTYFKPPEECKSAKVKRVNSVPKRIGGLRGPRGQRLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKF4</accession>
    <name>A0A8B7XKF4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973694</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080435.1">
        <property type="nucleotide sequence ID" value="XM_022224743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKF4"/>
    <dbReference type="GeneID" id="110973694"/>
    <dbReference type="KEGG" id="aplc:110973694"/>
    <dbReference type="OMA" id="KIGCTWK"/>
    <dbReference type="OrthoDB" id="10047126at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080435.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37836" checksum="D4ACBC9EBEA7D97E" modified="2022-01-19" version="1">MWPQYAQEYHPVELHELTLEELTGTRPTHRGTLMYLKQKGIPEDTIQFRDTGPQRGHLKKLVKAIEHDFYSGPVARHPEVQPPLGRGIRLRARDVGGPSQSRGYKPSSRSMASRELMTGRRDGRAAALFQRMKDRSDQYVVDESTAPGHYQQGSPYSEDHGQKLWQKSPWEAAAEDPLGLPDRAFEQPIPKPKPKPKLQNPAPVQRRGPPGYSQVDSIRQHQQAPRQPGSKPVKIGCTWKSEGNTLSKMRFHPGVRPYEMNYNRTARGWSQGNLQADDYEDGERYNPRPTSWSHEDGYSPQYGRQKSAEVARSRQVVQNVVGPRSWAGESDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKJ0</accession>
    <name>A0A8B7XKJ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Nascent polypeptide-associated complex subunit alpha, muscle-specific form-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110973835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080667.1">
        <property type="nucleotide sequence ID" value="XM_022224975.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080668.1">
        <property type="nucleotide sequence ID" value="XM_022224976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973835"/>
    <dbReference type="KEGG" id="aplc:110973835"/>
    <dbReference type="OMA" id="RGRNAKH"/>
    <dbReference type="OrthoDB" id="6288785at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051983">
        <property type="term" value="P:regulation of chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22673">
        <property type="entry name" value="FHA_Ki67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029334">
        <property type="entry name" value="PP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21603">
        <property type="entry name" value="ANTIGEN KI-67-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21603:SF18">
        <property type="entry name" value="ANTIGEN KI-67-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15276">
        <property type="entry name" value="PP1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="27"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="870"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="967"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1035"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1651"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="712"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="817"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1283"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1297"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1391"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1402"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1452"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1473"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1489"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1566"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1579"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1654"/>
            <end position="1669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022080667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022080668.1"/>
        </source>
    </evidence>
    <sequence length="1708" mass="180999" checksum="68985E6F0A9B630A" modified="2022-01-19" version="1">MPLYGKIVVIKRNESDGANFPLTLKQCLFGRTNECDIRIQLPNVSKEHCRIEVVDDDNITLTNLSTVNPTRINGKTLTSSVTLKHKDIFTIIDRSFRFEFPPGHANRLSTGKLDTPSVQSPVVSSTSGNKAKTPKKTPSKSPGKTPSKAKSPAVKTHVKREASPSSSVPAKKATPKATTSSPDSGKTRPTAKKAATPKTSPTAKKSPKVSPKASPKASQEVPVTSTTPVEKEGKTETPKKGTSASAKKVQKRLSGSAKAVVDSPRMPGSSSKSLKRSIGQLRRVSAPLKEEDEAASPKAASKITPKAKTTPKSVAKTPPKASPKAKTPPSKKKTPASNKKRKSTDGVAPSAKRKRVSFGPQLSPEQFDRRLPPLTPLRRGATPKSRRSFSGVASSPKVASLIKHRNSLAVTAIQESVEDIEKSPIVAKSPKAKASPAKSPAKTPEKVAAKSPAKSPAKSPSKSPAKSPAKSPAKPPAKSPAKSPAKKSPTATPKSSKKSPAKSPKSAKKPLMKIKLPVKPPSPSKADAKVATPKAVTPKEKPPVNATVSTLLTPLSGKKTQRVVKPSSKLMDESFTGLPEMFNTPSPVKKAAVIQGRVSKPTPKLALKKKLSTPLKKAIIEAAQERAKPSPKKMSTPLKEDIKNAAKALSKKATPKKMATPLKKAIAKAAAERPKQATPKKMSTPLQMSIKAAAAARPKVLSPKKMASPLQKDIKAAAEERKISTETKKMPPALKSEIEKGVALKKTKPKTPEAKTPTPKKAKTPTAEKSPAVKPASPKVNTPKAKNQALKTPAKKAVTIAVKSPVQTPAKAAPKPKTPKAKTPRAKTPKAKTPARMKTPRPMRWADIVKKGASKPSAASKVLVGRALKTSKTTKARVLSSKAKTPKRAYGVGSTGHAGSPATILIGRSQQTAKTPVRPKKGRKTPFKMAPPKTKSAADTSFTGLADMMQTPSPQKKAKQSLLDTTLDLSTPEGPGVMAVSPLTPRMPSPRKSTSPYKMVSPLIAEQTPMKSLVTVTALAAVKLSGKRMSEKFVSPLKESKTPMKTGKVVKAKVKTPAKTNTPSKVKTPGKRMSEKFVSPLKEGKTPMKTGKVVNAKSETPAKAKTPAKAKTPGKRMSEKFVSPLKEGKTPMKTGKVVSATVKTPAKAKTPAKAKTPGKRMSEKFVSPLKESETPMKTGKVVRAKTPEGAKTPDFSGISRLLKTPKIKPSPKTPKLGGIKQLMSSPKKVDPYEDFEGVPDLFVTPKQKPSSPVQASTKKATKRKASPSPAPAVKRSKASTPAPKREIIEPSPEKPTRARRGAVTKQTPAKKTKTPRKKAQAAKQVTEPSPTPVKQSRGKRSAVEPIEEPPTKKKAVSSAQVDTPQKAVTPAKRGRKGAADKKAETPPVKVKTPKKQTRGRKAVTAPVTPVVSVEPSPKKTRGRAKKQAIAPTPKKTVKIVSPVKAETPAPVKRGRKAAAKTKQVKTPKKAAPAKKAGTPKVDKVVPSPKKTRSVRGRRQVGSPVLSKVAPEKTAVKSSALKETPAKMPAKSKAVPKKTAAKKEVAAVELPAISPKTTRSGRSRKQASPAKPAKTPAKTPAKKSTRGKAAKTPAKKTTRGKAAKEVMEVVIITEPSPKKTRRGAIKKAATTPKPSKAKAVKNIVETIVIDTPTPKKQRVTRGRTASKAKTPKSASKALKTTKKVAKASPAITKKASPAVTRRTTRARKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLN4</accession>
    <name>A0A8B7XLN4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Protein tincar-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC110973936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080875.1">
        <property type="nucleotide sequence ID" value="XM_022225183.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080876.1">
        <property type="nucleotide sequence ID" value="XM_022225184.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080877.1">
        <property type="nucleotide sequence ID" value="XM_022225185.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080878.1">
        <property type="nucleotide sequence ID" value="XM_022225186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLN4"/>
    <dbReference type="GeneID" id="110973936"/>
    <dbReference type="KEGG" id="aplc:110973936"/>
    <dbReference type="OMA" id="PMLDNRL"/>
    <dbReference type="OrthoDB" id="10033661at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053291">
        <property type="entry name" value="Ommatidial_diff-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21579:SF20">
        <property type="entry name" value="PROTEIN TINCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022080877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022080878.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="68263" checksum="CB62C4DCD36E9FDE" modified="2022-01-19" version="1">MEQISPPTTVMVCSHKLTIKLNSLESIWYCIFVVVVTLFLCLDATRHYAHYDKLEWPQGRPSAELNLYILLILSAFLLIILFIPTQIFKVGNRANDQGKLGLFKENSNGRASLSTNRKIVKYFQAIRRVTKHLGPVGATLHFISAFCLLLPLMFLQARAIQYGLLTSDAIWRSEVLVGVTTVEEFEQLARSMHNNSGSFFPSNLNHTLSKIIPSVDPFKVYMVTLNYINYVIPLFFYGVRYADVFWFCHKGFAFVFSTQLMLNAIQYALGFIGFSLLYKLHWYGWHTYGIQADPVFQKPTGLVGVYLSNNITVFMSAVITYMYGYSRLKEAEYKQKAARTGIPINPTSFPLKCNGYIANIAAALVMCVFVACKVPLTIEYLGVYQVSKDARLLACMIFDTIYMAFWLFMWIGFTVKRDWDFTIHPPSDRDESTEQGSSSSVNQCFSVSSSQDVELRQISSSNERTEKNSCNQVGVLIRHKTSNTSHSCQGSSSNTPSERKIRSSEDSKGNVASNVYTRLFSSDSEGSFPAKPESFCPTASSCSPSRGQQTPSHFRGITRSPHRSSDPNSRSIEEESLLSQSINDELNGEEPQSPDKSCESQSADMVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMJ4</accession>
    <name>A0A8B7XMJ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Serine/arginine repetitive matrix protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110974219</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081386.1">
        <property type="nucleotide sequence ID" value="XM_022225694.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081387.1">
        <property type="nucleotide sequence ID" value="XM_022225695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMJ4"/>
    <dbReference type="GeneID" id="110974219"/>
    <dbReference type="KEGG" id="aplc:110974219"/>
    <dbReference type="OrthoDB" id="6287790at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097355">
        <property type="term" value="P:protein localization to heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22896">
        <property type="entry name" value="periphilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057603">
        <property type="entry name" value="Periphilin-1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028851">
        <property type="entry name" value="Pphln1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836">
        <property type="entry name" value="PERIPHILIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15836:SF4">
        <property type="entry name" value="PERIPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25234">
        <property type="entry name" value="Periphilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Periphilin-1 C-terminal" evidence="2">
        <location>
            <begin position="507"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022081386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022081387.1"/>
        </source>
    </evidence>
    <sequence length="577" mass="64800" checksum="2BBED8ABCD55663C" modified="2022-01-19" version="1">MSDFHSEPGPGEDPFSIFFKGFPNTVKASEVSDYFYNKGYHNHIAYQKVYNQHFRLFMALRFQDTESAKEVREKYTNTILFGYKVHLSFFKKHFARIHAPTINNIFMQDKLRKLRAQATRRPLFYRTRQFHGHYSPVRVFRPRTRRRSRSSSSGSDCSISPDRKRRDRSRDGAETKRRRRSHSRSRSSRSTSRSETPTRFSPNSSHSKRSSSNDKTSSYPNHVRKLCSKVTVVENNQPKKFSDSSQSSKERSQEHRSPTRGKPRTQSPSKDPFLSNFSPVSFGSDDDAMLMTPTPEPTTDGDPQGGAMSQKDQLATSYFAIKKAGQLTEAWIQSEGDSTPDGGGTPSPRGSSLAPKQADKERHSVSSKVGPFTEIRAMDRPWQLKPLTVQDECSSGSASSKHTDSSYVIKSPSSGNGSATSLSSEGTIAGNQIVMQTNRTEAGFVGSLSGTAQIRQPSLSSPPRPQLHPIPHEGTWSPGSSRLQSPSSSLGATPPKVNGVRKGEVIQTKLERLQAKKEEIIRAYKQDCDTFATVVRMLIRKDPELEQRLQQALRENLTEIGQRCVQELQEMVEQIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMN7</accession>
    <name>A0A8B7XMN7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Heterogeneous nuclear ribonucleoprotein Q-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110974607</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022082084.1">
        <property type="nucleotide sequence ID" value="XM_022226392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMN7"/>
    <dbReference type="GeneID" id="110974607"/>
    <dbReference type="KEGG" id="aplc:110974607"/>
    <dbReference type="OMA" id="NTAYEDY"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12249">
        <property type="entry name" value="RRM1_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12250">
        <property type="entry name" value="RRM2_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12251">
        <property type="entry name" value="RRM3_hnRNPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000023">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000024">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000027">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein q isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041337">
        <property type="entry name" value="hnRNP_Q_AcD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006535">
        <property type="entry name" value="HnRNP_R/Q_splicing_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01648">
        <property type="entry name" value="hnRNP-R-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18360">
        <property type="entry name" value="hnRNP_Q_AcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="183"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="260"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="19">
        <location>
            <begin position="355"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="521"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="521"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022082084.1"/>
        </source>
    </evidence>
    <sequence length="646" mass="71315" checksum="00384F97529A6881" modified="2022-01-19" version="1">MAEANGDQIPEEQQMDEEVQGETQATDEPMETETHVRTDNFDKYLGMGFSEKVAEKLDQIVTMVTDLTSQSEVQEELLDDRALEALKGLDDESSIAVLKQFSTSDLTHVNNKSAFICGVIKTFRQKSQRPGGAPAPDEHKGPDEAKIKEMLERTGYSLDVTTGQRKYGGPPPNWEGDAPGAGCEVFIGKIPKDTFEDVLVPLIEKCGRIYDFRLMMDPMSGLNRGYAFATFCTQEGAKECVKQLDGGSLGTSCNISIPKRRLFVGSVPKNKTKQEIKEEFEKVTAGLVDVIIYHGEDKTKNRGFAFLEYDSHRSASLARRQLMSGKVRVWNNLTVTVDWADPVSEPDEETMSKVKVAYVRNLAPEATEEVIQEHFKQYGEIEKVKKMKDYCFIHFTEREYALKAIEETNGTTFHGLEIEASLAKPRQENIKKKQRQMKQQQGYQGGRYYDDFYGPMRGGRGRGGLRGRGGFDRGERGYRDFGYGGGYDEGYYGGYPGGYDDPFNYEGYYGSGYDGFGYGGRGQGMGPRGRGGPRGGRGGMGGPRGGPAIRAGPRGGRARGGQQQQRGGRGGSGNRGGRGGNRGGNVSGKRKFEGQQPGDTKRRNTQGGWGVQPIAQQPLGEYSASYDYNQSYGDQSWSQDNYGSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN34</accession>
    <name>A0A8B7XN34_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110974259</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022081466.1">
        <property type="nucleotide sequence ID" value="XM_022225774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN34"/>
    <dbReference type="GeneID" id="110974259"/>
    <dbReference type="KEGG" id="aplc:110974259"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000608">
        <property type="entry name" value="Mov10 RISC complex RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049079">
        <property type="entry name" value="Mov-10_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049077">
        <property type="entry name" value="MOV-10_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049075">
        <property type="entry name" value="MOV-10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21635">
        <property type="entry name" value="Mov-10_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21633">
        <property type="entry name" value="MOV-10_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21632">
        <property type="entry name" value="MOV-10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="591"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1048"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022081466.1"/>
        </source>
    </evidence>
    <sequence length="1071" mass="121156" checksum="27AE8559EABB3097" modified="2022-01-19" version="1">MYQERFLLVERATCTDIANIFLQWWNADAVDVMTNQRAGRPSVAQSCRTGLGFLKFLQESERGDVDDKEQMKRVFLKEFKPTLEKGGVGFNFSSILYALKTNGKIRVKDGRVEILKGFLAVDQYVTLKKHTLDQKEQARATPGDRRVGGGARGKSGEGNEPYPFYCEECGVRGNSHQSFNGHLQGTRHRQQMILKCVKRSRSKFIENKNGIEITSQQDGHDGIIALKSTQGTGQKLSVTVKNRSDRDTIAFLSCVFLKVQPAFVLTDEYEVSQSKRVVHLKPGSEYSLQVAVESDSVGILSSPLIFAFKDVTSNEVFHILRFVTVEVTSEIAEDLPPSVPYQRPPRISRREPKGEIVEGIQLPQSSKSKLKLKEIKQYSIPNHLRWMLNNKNQVEGIRKDIKPDLAWSNYSHKLTTLLHIEECQMEVDIKRYDMRGVAMRQDGRFLRLEIPGLAENRPSVLKGDHLFARPSGDPAGSKTFKGYVHRVEMEEVVLGFSKELIDKFVKGLKFDIEFTFNRLPLRFQHNALDDATIHDMKRALFPLRSDIGTKKELCSVREDTGEFAGQFFDKKLASNIEQIKAVQHIVRGTSRPAPYLVFGPPGTGKTVTIVEAIKQVYSQMRGSRILACAPSNSAADLIATRLLTGGTPIAKTTIMRMNAQSRDWRSVAEILKEKDVCNYDKQGSRDTFYPPKEELVDKRILVTTLCTAGRLATAKDFPYDHFTHVFIDEAGHAVEPEAIISLANLLNPNNPRGGQVVLAGDPKQLGPILRSPLAIEHGLGLSLLERLMTESSPYQRQEEEPRYDSRVLTKLLRNYRSHPAILKLPNQMFYENELEVHADEMVRNSLCSWSKLPQKDFPILFHGVEGKDEREGQSPSFFNSAEVTVVVEYVEDLLAKRGGRKIKESDIGIISPYRRQVQKLQAVLRKRHHSDIKVGSVEEFQGQERLVIIVSTVRSTKPEHIQMDIDYKLGFVKNPKRLNVAITRAKALLVLVGNPYMLSKDECWNKFLQYCLENNAYTGCHFEEDEDALEDIIQKMDTLKISDLVDKPEGGEDQGVSAVAEQMDPEWRGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN71</accession>
    <name>A0A8B7XN71_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox even-skipped homolog protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110974360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the even-skipped homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081622.1">
        <property type="nucleotide sequence ID" value="XM_022225930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN71"/>
    <dbReference type="GeneID" id="110974360"/>
    <dbReference type="KEGG" id="aplc:110974360"/>
    <dbReference type="OMA" id="PCACHHH"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048663">
        <property type="term" value="P:neuron fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000417">
        <property type="entry name" value="Even-skipped homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052002">
        <property type="entry name" value="Even-skipped_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294:SF4">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081622.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="40106" checksum="EF0E6D332D78940C" modified="2022-01-19" version="1">MPAESSSIEPSQAIAMSTSPDLFNSQNIPLETRLYPSCSSFKRARDRDGSGAESDAPRIASPNTEMGFHYHEFSGASSDSDAGEERHRAREQHHSGSLRNTSPIHSEKYDSLASASMYAVENYGKGDKGVDSQVRRYRTAFTREQISKLEKEFTRENYVSRPRRCELASTLNLPETTIKVWFQNRRMKDKRQRMSMAACSWPHHAALDPNIYSLMLAGRLPYPCPSTAFSYYQPGPPTLSPTVGPSHHDAYSSYAMHLRGRSADLLRSLCHPYSRLATGAPTFSASDLLAARASAAAVAAANSSFIAPSSVPSQAALPCACHHHYGHAHHALPGSQPSSAAVPLSGVGLGINRDPESGICALPPSVHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XP67</accession>
    <name>A0A8B7XP67_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110974452</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081795.1">
        <property type="nucleotide sequence ID" value="XM_022226103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XP67"/>
    <dbReference type="GeneID" id="110974452"/>
    <dbReference type="KEGG" id="aplc:110974452"/>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="12">
        <location>
            <begin position="51"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="13">
        <location>
            <begin position="250"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022081795.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="50431" checksum="5AF0D4D07CCA0D0F" modified="2022-01-19" version="1">MGVRECISVHVGQAGCQMGNACWELYCLEHGIQPDGHIPADKVIGPHDEAFSTFFLETGAGKHIPRAVFVDLEPTVIDEIRTGTYRQLFHPEQLITGKEDAANNYARGHYTVGKELIDSVLDRIRKTADQCTGLQGFLIFHSFGGGTGSGFTALLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSVLTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSMDQGELEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPH7</accession>
    <name>A0A8B7XPH7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exportin-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110974510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081900.1">
        <property type="nucleotide sequence ID" value="XM_022226208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XPH7"/>
    <dbReference type="GeneID" id="110974510"/>
    <dbReference type="KEGG" id="aplc:110974510"/>
    <dbReference type="CTD" id="64328"/>
    <dbReference type="OrthoDB" id="5548448at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000130">
        <property type="entry name" value="Exportin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF1">
        <property type="entry name" value="EXPORTIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022081900.1"/>
        </source>
    </evidence>
    <sequence length="1142" mass="129008" checksum="0A0E3A196F5A7127" modified="2022-01-19" version="1">MAAFLSDLEHAAQLIMAPPALVSKEQRQSAEHVILAFRKSKAPFAACRHILEHSKADYVLFQAASTIKEAAVREWLLLNRKEIESMQTFLLKYVMQNAKLPNYVREQILQAVAVIFKRGTMDMKDTGRDALFTDVSQMIASGQPQLQLMACSMLTALLNEYSSSSRTSAIGLSWEFHNDCKRLFEVKDLKRVFLFAVQVLHQFEANHAALGQEATTVCSRFLSIAEQVLSWDFMLVRPTRRRIGIFEALQAPPLKPDASWKDVLLDKGLLELFFKLHSKVRQNVEMCHHALQCLAQLASLSGPVLSSDKVTAEYLSHYVQCLLQMLNSTALQDHEAISIATIFNSLVTRFPPSALLAIPSDLLTSFVTCVSSLTCLFGRKAALEEAMHKDDQQYMEAYDKLLECWISLLENSSKFPDGYFKPHASQIFNLYLQCHLGAPDGLRNLREDGETSDDEEDINEVEEDDRELFEEQLSCIGVLGRAVPEHSIPLLSKILEDRVTSLQSHLMRLQHHRTGATSSHNLDLDMKRLHCLFEDLHWLLLITGFILANESKGETPMIPAEIMQYSISQACNVDVQKMLRFWTSSADIAQPIIDDEKVDRVVRLIAAILRLAEVERQASSDFAEVLSPQVGRSTVWCLRRWLIPYLLLHEKYYSEISLPINAVFGQDSPSGQWTVNFLLQKVVTNLLVWSSEHELAKDTIDLMVALVNRKDKAIPATQCDSYWVLAKLHSSKPSKLDTLPLDVRSSLMQALVMAGSCIPDNTAERQRFENEILNPVQSAFRELLHREDFAGRALVAEVQAQVAHLLCLLRGVVLGTQVNRASDLFTFCLPMLRDGVSLLRIYRNYPEVVEQVLEVFVEVAMHQLCFLTQAESVKMYEVSLALLQAYSEVNLGRTNLGVLAEEEQYRDLSLMMELLSSLFSRDMFVFLDDGRHIEDVNNAIESSDIVLHGLNIVVPLMNANLLKFPILCSEYFKLITFICELFPDKICLLAESLFNNFMASLEVGLTEYGADVTKMCLDGLATLAGHCVENQMTEGALFQAMRHFTEVVFKIVLMQTFDMELISSAAEAFYSLICCHQAKYTELVNVLLGSQSDPAICQRLAEAFSKLTPADEPLQMSRKNKVQFLSRLETFLFNVRGFLCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRZ5</accession>
    <name>A0A8B7XRZ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Nucleobindin-2-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="22">Nucleobindin-2-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">LOC110975435</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nucleobindin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083623.1">
        <property type="nucleotide sequence ID" value="XM_022227931.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083624.1">
        <property type="nucleotide sequence ID" value="XM_022227932.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975435"/>
    <dbReference type="KEGG" id="aplc:110975435"/>
    <dbReference type="OrthoDB" id="5982823at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057576">
        <property type="entry name" value="NUCB1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25434">
        <property type="entry name" value="NUCB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665462" evidence="18">
        <location>
            <begin position="20"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="192"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="416"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="451"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022083623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022083624.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="78226" checksum="3BC70AD59ED9D6F7" modified="2022-01-19" version="1">MERWRSLVLLLALLAVCRAAPVLPEKTDTDDEGDIEDSEHTGLEYDRYLRKVVKTLENDPVMKKKLDDLSLDDLKTGKMMEILDGVSDKMRARLDDLKRSEIQRLRQVARQRFQQAIFDDNSTTNGDHRPMDQKQIEDMTGHLDINNMDQFGGKDFEKLIKKATEDLDKADKERKEEFKRYEMQKEIERRQKLKEMDEAKRKEAEQEHEERRKKLKEKHMKHPGSKPQLEDVWEETDHLEREDFNPRTFFNLHDTNGDGTLDAFELEALFVKQVRKHYEMADNSHVDPVKVREEIARMREHVLTEIDKNKDKMVSRKEFMEATEAEDFDEDKGWDDLEEQDIYTEDELETYEKNIQEEMKKLKLRLQQEHDQYKENRVPQPGDPVVMNQAKAAISNPQQLADQVIQAAADHEAEKFHQASQQMKKLVDEVANQVKANAQGGQKPQDNTQHQQQQQQQQAQIDAQKIAQQAQQQQAQVKAQQEAAQRAQQQQAQQAQLKAQQEAQQRAQQQAQQEAQQRAQQEAQQRAQQQAQQEAQRQAAQEQAAQQQAQLKAQQQAQQQAQQQAQLKAQQEAELKAQQQAQPQAQQQAQPQAQQQAQPQAQPQAQPXQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQLQAQQQAQQQAQQPGMPAPAANQNPPGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XS07</accession>
    <name>A0A8B7XS07_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="1">PARP</shortName>
            <ecNumber evidence="1">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.4.2.-" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022083638.1">
        <property type="nucleotide sequence ID" value="XM_022227946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XS07"/>
    <dbReference type="GeneID" id="110975438"/>
    <dbReference type="KEGG" id="aplc:110975438"/>
    <dbReference type="OMA" id="MEFTACE"/>
    <dbReference type="OrthoDB" id="10071692at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051712">
        <property type="entry name" value="ARTD-AVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45740:SF2">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PARP catalytic" evidence="3">
        <location>
            <begin position="138"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="423"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="696"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083638.1"/>
        </source>
    </evidence>
    <sequence length="757" mass="84698" checksum="7EF06969B6AB0BC7" modified="2022-01-19" version="1">MCLQITCSLRRLDQDFVSTDTMDLYQAADDEMETDGSTDPDQTGLVQHDGNGSSLDQLKSEQARLLQHLHSSDSFTSLGGGTGHVANPEPNGAVGGGASPEEQQATSQAAALSETTVVSPTGLSMPGLQPFPPAKNQLPSSWSDCTLSPDVPFCLVMLNKQSWEFQSILAEFTAADLTVKKIERVENRDLWDKFQFERTRMLKNRAEVNEVYLFHGTTADKEQICHEGLDQRLSRIGYFGRGIYFSNDPRKCVSYTQGDKGSGQPLPQMTCTIYKCRALMGNMKVYPNGQHAKDLKREPEVENPEPGGPKYYDSVKGHVKEYDEFILYKSERVMPEYVISCFMPMTSSSQGSVTLPAVTPLTNHGGGANMVLYGGLDQEEVNAELAAGVLSTHSNKGLSKGTDDGEISAELAAGALGLPKGTVARQTEKKAEDDDVSLELRAEASERPRAEEVTEDSHPELEGEGRKADSHLELREDGDVYEQLHQREILDAIRARERREKEQLERFLEFERQKGPRDAGRKEWAREEPHSITINQLQDEEVSAELSVGGTDTTDAEREQKQPALQRPTQLLKSSEPIITVNPLEEEPRRYKKETIAPEFLPTVLEVRERVQKARLKEKEMEGKTKQTQGASTTSERKTPRWVHERDAPAWTPREYAEQQKLIGKVREKVRADRKAEEQERERQRRSGKEGRSQKTTDNSLSPQWKGQEDDGVGEVMDVLIVQFMEVTACDDITEAREFIQKANMDVNTAIISYLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV29</accession>
    <name>A0A8B7XV29_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/arginine-rich splicing factor 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975508</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083746.1">
        <property type="nucleotide sequence ID" value="XM_022228054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XV29"/>
    <dbReference type="GeneID" id="110975508"/>
    <dbReference type="KEGG" id="aplc:110975508"/>
    <dbReference type="OMA" id="TVWITRN"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="12"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083746.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19473" checksum="C002B35B8C16A0CF" modified="2022-01-19" version="1">MSHGRDHSKPAYKVYVGNLGSGASKHELERAFEAYGPLNDVSVVPSSGFAFVEFQDPRDAEDAVRGLNGRRVWGSRVRVEMATGKRQYHNRSRRRSGGSHEAQPPSKSQNRGGRSQSHSPSRSSSQERNRSRSPGCRRDEDESEQARSRSRSPGPERDDQEQRQDVNDDGHKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWJ4</accession>
    <name>A0A8B7XWJ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Macrophage mannose receptor 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110976017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084627.1">
        <property type="nucleotide sequence ID" value="XM_022228935.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976017"/>
    <dbReference type="KEGG" id="aplc:110976017"/>
    <dbReference type="OrthoDB" id="6356110at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034691104" evidence="3">
        <location>
            <begin position="22"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="31"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="183"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="329"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="483"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="636"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="794"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="936"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="1085"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="1237"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="1385"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="1537"/>
            <end position="1662"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="1690"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="1848"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="1990"/>
            <end position="2112"/>
        </location>
    </feature>
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        <location>
            <begin position="2114"/>
            <end position="2137"/>
        </location>
    </feature>
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            <begin position="2117"/>
            <end position="2131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022084627.1"/>
        </source>
    </evidence>
    <sequence length="2157" mass="240433" checksum="3FE31A8522B50D62" modified="2022-01-19" version="1">MAGLCVWGLLLLAVAVPQVYSIGCPDDFYMFGDICLSLIRNTEKSWDDADADCKALNESASLATIKDYRVQAQIVAMMRSAKGDDIYVGLKATPSNPFFFWPDLSNPAFERWGTGQPDGYPLLTNEDYCVVLDNSNERQPGFWYDVPCTEPHKYICSMDLDVNSDGSGVPPALRCPYGFYALGDSACFGFNDTLSTYTEAEAACQALAQNPGEEIHLAMILDGYESALIETMMYSLGLDSGWIGLKSTDREFSWETGYPIVYTNWGLNEPSSENKDACVHAQTDGKNWDDTMCDDRAAYFCRFDRFGLSYPTPDPDLEKLPCPTGWVGFEENCYYFSSIKRDWGESNYRCMQSYEGSFLTSITSASESQFVLSQAQSQYPMDSSIWIGLVRSQTGNNDWSTFGWLDGSEFNYAFWSRGEPDGYPTDLLLESCGTMHITTAGAGAWSDEICQFSALYSVCKMPKQQNYTERICGDFFNSDEIQIGDYCYLPSTVTGFTTSTGTWREAENACRAKGGNLVSIHNPEEQALVRILSYGFARSYWIGLRKFGNSNFGWSDLTDFDINDYSEFPNDQLPDNLADEEECAELLIWQNGEWGTSACGNSLNFVCKRKETEGSPKPLLPDYPTTGDCPDNYFKLGNMCYSVKGTTASERKGWIAARDDCRSGKAARGWTLATVSHPGQQALMTAIIKAFEGVDMWIGLNGIGIHNQYHWSDESPLEYTAWMEGQPDNVLPITDPNSQSCVVMMNNPYDPGRWNDVTCSVPRAYLCQSPLVTPGGTPPDLPGNKCSDNRYTQYFATCFLMENTYPRTFDDARADCQSKGGNLLSLSDQYEMALLVSALYGTYPNSPLEAWIGLQSTTQTGTYEWIDDFPLEFTKWGPNEPNNNNGRCVVLTPDGYMAVRACSDTRNYFCEYPSTPPEKPQPQRGTCPGDYVELPGTDSCILFKTQNLIVHDDGDYICTTQHDGGRLPSIHSIAEDNFIAEEAKKVFLGTNVYVWLGMRRSNEGFNTWIDRSLMDFVNWKTQEPTDDRFPDNNCVRMDVNGGWEDVGCSQRSNYICQLPKKPALPTPPPTRDVIKSECPDNFYRFGDTCLTLISSDEKPWTDANDACESLNSKASLAIIKDYRTHAQIVALMRGYAGQDVYIGLKATPSFPLYVWPDDTTPTFTRWGVGQPDGYPLLTNRDYCVVMDNSNTKQPGYWYDVPCSERHRYICSMDPDPIYDGTQVPPARRCRDDFYAVGDSACFAIFTSLPSTFDEAEAACSAMSPPPGQGPQINLAMVLDGYESAVLDTMLYALGQNYAWIGMKATDREYGWVTGYPVVYTNWGLNEPSGQDNEGCVRTRIDGDNWDDTTCSDTAAYFCRYDQIGMPFPTPDPDTGNPCPSGWESFESNCYYFSDIVTDWGEANFRCLRMYEGATLASITSAAENEFVYSRANNRYPGGDFVWIGLTRVQTGNNDWRSFGWIDGSEFNYAFWSRGEPDGYPADLLVETCVTMSITTAGAGAWSDEICQFKALYSVCKMPKQQTYTSRECSGQDIEIKIGSDCYLPSTVTGMATADATWREAENICRDKGGNLVSIHSSEEQSLVRILSFGFARSYWIGLRKYGNGDFGWSDGTTFDINQYSEFPGDQLPVNLADEEECAELLIWQNGEWGTSACGNKLKYVCKRKESGSSPKDPLPDYPTGGGCPDDYFKLGKMCYSVKGASDGEGKGWIAARDDCRSGRTERGWTLATVSHPGQQALMTAIIKAFSGVDMWIGLNGIGIHNQYHWSDESPLEYTAWMEGQPDNIIPITDPNSQSCVVMMNNPDDPGSWNDVTCSVPRAYLCQSPLVTPGGTPPDPPGNQCADSRYTPYFDTCYLMDSSSQRSFGDARTNCQSRGGDLLSLFDQYEAAMLTSLLYQDDFDESAEAWIGMRRNTATGVFEWIDNYPLQFTKWGPNEPNNNNGDCVVLTRAGYWAVRGCDTIKYYYCEYPTQIPEKPGLRGGVCSGDYVELPGTDYCVVFDTPSQIQYDSGDYTCSTKHNGGVLPSVHSQAENDFILAEAKKVFGEINTKIWLGMRRDSTRFNSWSDLSLMDYANWQANEPSDDENENNKCVQMDLMSGEWADVNCNLGANYICRVRKQPGPPTRSPTQPPPTKPNSATQPVSGLLSILLSAAALLFARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWM4</accession>
    <name>A0A8B7XWM4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup214</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">214 kDa nucleoporin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin Nup214</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110976379</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085278.1">
        <property type="nucleotide sequence ID" value="XM_022229586.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="aplc:110976379"/>
    <dbReference type="CTD" id="8021"/>
    <dbReference type="OMA" id="RISSICW"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000142">
        <property type="entry name" value="Nuclear pore complex protein Nup214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF46">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="13">
        <location>
            <begin position="36"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="377"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="488"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="560"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1171"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1291"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1531"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1629"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1793"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1912"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2043"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2111"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1103"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1176"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1197"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1216"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1292"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1316"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1355"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1535"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1569"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1798"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1846"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1925"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1961"/>
            <end position="1971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1972"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1997"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2059"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2111"/>
            <end position="2128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="2129"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="2147"/>
            <end position="2178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022085278.1"/>
        </source>
    </evidence>
    <sequence length="2186" mass="223140" checksum="13EC4A4430FFAA2A" modified="2022-01-19" version="1">MAEQETGPAEREVTNLRFHQLTRLKIFDEKPETLTPSERCQLLAVSSKYGYTFVGCEAGLKILKTKEITECSDKHPESPNTSVEDYDCLKVALSLPPVNLALSPDDLTLAVCSMTDSTLLVALFDTRTLVYKSINASPFAVATLSKESDCQLVNLLWNPSNPTLFATCLSDGSMALWDCSEDNIRMLAQLPRDVEPTAICWSPKGKQIVVGTSSGKLIQYNHKLEQKKMIPPADFSEEPIKVVDILWLSTYMFAVAYIDVEETLQPNLTIVSAPKDGQPTYTNFEDICYGSSELRNTHYQLVHLDKWGFILATSSNSMEAAVIGHSLEDKASWEIWTLDDAARIEMPLSGESEDTFPMGLALDLSSESDIVVEPITHKAEPLPLEGERVAKGRAEPGQTQTTKPPVALDTSKPTAPPPIHKSSSTGSFSWGSSSSSSTPSSLGSAATGTSNRSTSFLFTNTKALDSSGQFGKASSAASSSIETTTFTFSGKPVDMRNGSAPKQDAPSSLPPKASPVSTSLAQSTPFQGASPFPFKVPGVQHVTARGLPVDQVASIQTTTQSRFVSQETPDAAPSVSGAPIHPASPSAFATSHQKTALETSSTMGSGSQPQADSVKVPGPPATFGQQQVIQTSAVGKASSSLIFPPAQTASPHRAAPPNQVAPGGASIVPNQFTPRGASLVPSQVAPGGSGVIPNQVAPRGTSVIPNRVAPGSASPVPNQVAPGDASVIPNRVAPGNASVIPNQIAPRGTSIIPNRVAPGSASPVPNQVTPGNASVIPNQIAPRGTSLLPNQVAPSVVPNRPALQSTLPNQFVALSTLSKPPPPAYGASLPQQQAVPDFRPPPTVQAPSTVAAGVKPSGRVSIQIEYFKKELEELQNHTKRAHFEVGERSEQETIKKNADELVKFRAEVLTVTKSHNEEIHELKGKLLATFAQLEDARTLRQRNTDPRYLHLLRLRGLDPQTAKKLRNIHSNFHYLDTGLADFNHILYVSSEPISVLLRFAYSVETVREKGSCTFGWIIFPCRSGDLTSLAAKLSSTQITSPAKARSTPVSSKKQAQLRKALSRRATTPRRTASKVDLSGLTSPALSHSSQENLSPALTSRRLRYPDEEPRQPQPARREAIDVSDVPDFRIPSSFGQTKPGGGLVPLVGVAGQRFLGAEATSDSMKETRQLTAAATPAPPSTYPEPTPSSSTQALPVATTSPSSFTHSGRGTVIWGSQTTPTKTQPSTRAPPNSAVLRKVVEKPPDLPPVVNIKNFSQTTKPPPVTFAPVNSSVDAGTAKVVNQVLAEVAKTSGYSQPEASADSSKIQDRKISFSDEPPPFVQPFPPSKPALDKTAGSGAVGFNSGSTKPPAVQSLPASMSVTPPAATTSTLAFSGSSTAPGPTFSGSVFGAKKEDSSTSAASATQQGFSGLSFGSGFGSARANTPSSTVPTATSALPTSATTAASKPMFGGAGFVASASSTPTSLTLSLATPQQSPAASSIRESAGASATNIPGVKPSLFDFKDQKSAASTSTPGGFFVASTSSVKESIPVQKETTALPTTTVSSTEATTTKPTASPNVSVKAIPKTAPPAQSVQPSQPATATVTSAPTSTSGASVKPFPRMSLQPATSTAPGRLKQLLVGEDEAGTGLASKPALAGSAAPQPSGEDEAGTGQPATAAVVVSDTDDHPPSAVTQPATAAVTTAATGLFGKPAVTPADAVTGTSGGMFGAKAAAGTPFARAGAVTTATATTSGTSAGLSAPSFGAPSSAGLFGAPQFGVSTQPSASVSAPATSAAPMTSAAADKPKTLFGLLKEDQPAPSESSSGTLFGTATSKDGGSVSKNLFGQPTSTSASPFGQSATTSGGLFGQSSSSNSGLFSKPASTTSSGALFGQSATPASSGGLFGQPISTASLFGQPSATSSGGIFGQATSAASSPFQQAGSGGLFETSTSVPTFGRQTEGVFGRPSSSAPAFGQGHSLFGQTPTTTPSSGSLFGAGGDGGGGFFSGLGSRPNPEAARSNPFGSPSVSSSGFGGPSAGSSSLFGNQGATTFGNASSTTGPVFGGSFSSPEGSVAKSGFGGFSQQPSAPAPAGGFGSPPTFGSSPAFGSTPSFGGSAFGSSGVAATSPFGQPSAFGASGSQTTGGFSGFASQETPTFGSLSSSKPQQQGGFSGFGGGSSQSGFGGFGSGGQGSSGSSGFGGTSSFTQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXJ1</accession>
    <name>A0A8B7XXJ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Unconventional myosin-XVIIIa-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110976551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085603.1">
        <property type="nucleotide sequence ID" value="XM_022229911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976551"/>
    <dbReference type="KEGG" id="aplc:110976551"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01386">
        <property type="entry name" value="MYSc_Myo18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06747">
        <property type="entry name" value="PDZ_MYO18-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000059">
        <property type="entry name" value="unconventional myosin-XVIIIa isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036064">
        <property type="entry name" value="MYSc_Myo18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057772">
        <property type="entry name" value="SH3_Myo18a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF36">
        <property type="entry name" value="MYOSIN HEAVY CHAIN-LIKE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24556">
        <property type="entry name" value="SH3_Myosin-XVIIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="9">
        <location>
            <begin position="243"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="459"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="770"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1971"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1282"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1407"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1734"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2000"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2054"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2065"/>
            <end position="2074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="2075"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="556"/>
            <end position="563"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022085603.1"/>
        </source>
    </evidence>
    <sequence length="2112" mass="239298" checksum="9B472C03B25B29F5" modified="2022-01-19" version="1">MFHFKKKDRDSKKDSKKEKKERDKQEKHSFKQKDRHKEKSMTEEELSRLDEIKRGLFPGRKISITKQQSAKSDRTDGYHAPGVEIRNSESNYSMEFTSGSDEASANSVRSSLEFPVSQMVDEDGDKAVDVNGKMEQTEQPPFVKKGSGSKKSILKGKSSYGLPDVSAGTVSTKLDDMGILADNTAYNELIAEKTRSSSLRSGSQFDEIYLEPIVHSPGPGEKTFDVDLPLPDIVVPKPPRKRDVVLQRQPNGGFGFTLRRCIIEERGGLGGAITRRTVHFAEPSATQKDNTSGLLPGDRLVEVNTENVESTPRDDIIAKIRGSTDTVSLKVQPIPELIELSHRHGVDGSEMNLEDQILKTGSLAQSSSLRIERDRYHNDFCSLHDAAKSDAQLDSEKAWLGAEKVWLLHKAGFTAAQLLKDEGIVPLAEGRIRVKLVHSDDALEVDEEDVEKANPPQYDRAEDLASLLHLNESGVLHTLRQRYGASLIHTYAGRNLVVINPMHQLSVYSDKHATAVIQLFKGCKPEDMPPHIYATAQTAYRNMLATQLDQSVVFLGRSGGGKSWNARHTLQYLTQVAGTVSNMVTVDKIQAVATLVDAFGGARTVQNTSATRCSQILSLDFDHMGQIAAGSLQILVLEKYRVVRRPASERSFNIFYSLMGGADETLTKELFLNHLAPDNVYISPLQRSEEKQPTTTAWNKVLHACSVLGFSSEHCKALWCVLAAIIHLGAAGATKGSGSSKAQFRKPTEAQKAAHLLGISLEELAKNTFSPRLGGNAPRGSLRPVVNDPSEQGATPRDALESMMVGLYGELVNAVVSLINKALSSSYRTVSSILVVDVPGFQNPTACGQPGGASFHDLCMNYAQERLQLLFHDAMFTAQQDKYAQENIDCQFEQADTTPEAMVNLLDKQQGLMRSSNLDLRDVDQKGLLWLLDEESIFPGATDESFMERITIHYGHLARKKDGLLRGCKDKNNFILNHFQGTTPIQYNATGWLRSCREHPVVRMAIVVLQESQKNNISGLFVSLAGSLPSTMVGSVAGIEGSSSLRRASSIRRAWSSGTAAIKRKSICLQVKFQVDGIVDSLRRTRLHFVHCLLPQVNAGLCELKNLGAKSPTSPTPTSDGLIDVPYLRNQIRGLEILESTKLHKYGFPESMLFTEFRRRFEVLAPATAKVSEPVLDERKAIEELLKHCDLGVSMYRLGLSQIFFKPGALVKLEDHRDERLAKTITEFQSYCRGYLGRKQFKQLKIQHLAITAIQRNVRKFLAVRTWPWWRLVTKVLPLLDVHRTEEELKMKDHELTELRLRVEKLEKERNVLKHNHDKMEARLAEMSADLTEEHTTANHASEMLERETAERLRLEKELKELKVAHGNLQRKAERLDMEVMESRMMRSSYMDGDMGSSDEEEDSIYRSKYEQARREIELTKKRLKQEHEEEIESMKAAKKAQDRRLAEAVEEVEEERKQVGVLKRKVQKLTGEAQDTRLHLESQQARNSELEKKQRKFDAELHKVQQDLHTEHLVKERLQREKEALQSDNYILRQELEDIRSDVGIKEKRIEELRCEMSDLSSHGSKEVTEVAAIKRQKRELEAKIEDQEEELDEQAGKILQLEQSKLRLEMQLEKQKQASQKELEAKDEEVEASRSTFQNRLKQLENQIEEDYKERQSLMRQKRDLEHKLAELQEHPRASDRDTERRLRKDLKKTKALLNDAQVMLERQKASAPSSSKIKQLKNELEDSQYATMAAVKARQSMENELAELQNQLEDVSRAKAEADEKISQLNREKNDVQTRQEDQEEDFNDLLKKHKALVLQSSNDQARVNDYIVQISDLTQDKHDLEEKVSEIQSKMEFMTSTMVDRTQLARLEGRVRDLDSRLALEKTTRQKYENQAEKLKENIEKMSSEHDHMSHKDQKMQETVRRLQRELRELKEEQTDRQRRETEANKKKLELEETVDTLEESNNKLQSDLKLAFKRIADLQHALQDNDDSESDFGSTESDSDDMPEYSRRYSRYSSRSYRDSTSSLESTPRLARRRVLSSASEDAAPRKAKYTVNPASSDEEEFEPRSTSRPSSMYSEDSKGSKDSGGDLLASSSSPPAGEDRDSTLTSSTGTKKKGFVVNPDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY72</accession>
    <name>A0A8B7XY72_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arachidonate 5-lipoxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110976201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084980.1">
        <property type="nucleotide sequence ID" value="XM_022229288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XY72"/>
    <dbReference type="GeneID" id="110976201"/>
    <dbReference type="KEGG" id="aplc:110976201"/>
    <dbReference type="OMA" id="SHYMRTH"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00113">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="6">
        <location>
            <begin position="13"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="7">
        <location>
            <begin position="124"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022084980.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="76223" checksum="931F836DE1C96D70" modified="2022-01-19" version="1">MGNACVSGNISPPDYVILVKTGDVKGAGTDANVFIALFNKEGIRSRDIPLNSKWKNDMERGSTDRFPVTNLANFGQVCKIELWRDTDGAMDSWFVERVEVICEKSGEREVFPIHRWLKALKRHTFLCNDCLLPQFDERKQERKEELEEKQMLYELECKVEGLIPQVKTFPSDESFSDDYKWDIIKNRTKLFVHVKLMDVKTKEWTSLEDIERVYNDQLPVPYGMNNWRSDVEFGSQRLTSCNPNQIRRCTEIVKNLAVSDEMLKPLLEGLTIQEAIDAKRLYILNYKILKDLPCSYGRKICAPIGLFFVNKEKNLMPVAIQLFQDPAEDNPVFLPTDPEYTWLLAKMWFNNADASYHQSATHLGFTHLIVESIAVATHRTLSPSHPIFRLLAPHFLYLIAINYRALGKLVSEDGWVDQCMSIGRIGMFEIIVRTKPSWRLDVEGTLPADLKNRGVDDSEALPNYHFRDDALLNFEAIQTYVAEVVNGTYDDPVKLAEDNEIQEFAETLTKPSNEGGAGVLGVHGNGKFTTNAELIGALTAIIYTSSVGHAAANFAQYDEYAFPPNYPSLMRVPEPPRDKSPRSEKDVIDCLPEKEKTLSIMLVTKILSDRGTNSLGDFEVEYQFDPIGKKAVESFRKDLLRVGAIIDERNATRASPYLYLHPKEVPNAISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYV1</accession>
    <name>A0A8B7XYV1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SRC kinase signaling inhibitor 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110976468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085427.1">
        <property type="nucleotide sequence ID" value="XM_022229735.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976468"/>
    <dbReference type="KEGG" id="aplc:110976468"/>
    <dbReference type="OrthoDB" id="6022652at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1540">
        <property type="entry name" value="Actin interacting protein 3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022782">
        <property type="entry name" value="AIP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051825">
        <property type="entry name" value="SRCIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741:SF10">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN CG32809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22741">
        <property type="entry name" value="P140CAP/SNIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03915">
        <property type="entry name" value="AIP3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Actin interacting protein 3-like C-terminal" evidence="3">
        <location>
            <begin position="215"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Actin interacting protein 3-like C-terminal" evidence="3">
        <location>
            <begin position="690"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="704"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1090"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1340"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1613"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1765"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="723"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1136"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1304"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1341"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1361"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1394"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1508"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1619"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1650"/>
            <end position="1665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085427.1"/>
        </source>
    </evidence>
    <sequence length="1860" mass="205494" checksum="C3DD70612C0B046E" modified="2022-01-19" version="1">MASRKIYRRTRSDARNEHRYAALLGSRLYTSSNNRKGRASGLLLTVTRSEPSLGTDEQGGGLRVNPAYLEQGQVATSSTTSGQRRATHSISNNSAQRPHHYYRERDRRHTLASHTPATAAAPYSQRPTTNEQKRELFLEYLKQKYPEHSGTIEMAKKPDQESLTFSNGFYDDDGTMSEMDTQATGFQRGVRVRTSLPGSRPLVNKSKEKPLGLVYLIYMSETKRALMPNEVTGMDTVKALFVRAFPRKLTMEMLDNPQRKIYIRDNSSEIFYELEKLDEVKDRVVLKIYEPGFVEETPVNIRNSTSTPLDLNICSDSELADIELPDFRERSYKTMGSRPTGTGQDRFDPLMKRPNSTTPMEMGSRRMHPQQGRPNTSTPLRSPPNNEPFQRGAPERSTAPVRPSSQAPFPRGSPQRLSSSTTLPRQQHHQQDGRRTPTNGRSLTMPRPGERGPVHRPHPEHGRQTTAMMPGPGPDPSRHPPVDRHRDPHHPQQGGGARTLERGMGPPRGTPQRTPDPRDGPRGGVPPPQHARDPPYRDSPRGHPPPSQQQGGGGSPVKAPRGEMRTDGPPYPRQPLPHEMQGRPPSRNSNQGMRQPPPNHMHPGPNRPHDRTMDRAHDRTMDRPRDRSMERPRSTPPHRVEHRGLGPPPMKHPHPPQANIREVEARMVRQGQISSTSPPGAETSERITAMEQQIASLAGMVRSVLKPGEQPPPGQQTPPPPSQQQQLAQQQQQQVSSPQRQVQQRAITDRLVSPVQTPNRSGSELTGLNEEVIRATQNQKTFTAVDSYRDGTDSQSVTPQPMSAVNTSELRETTLNLKHTVRDLRDQLKQIRKLQLNMVQDMNVAFRATNRKVQLALEATPAGNEHPIRALRTRTHQDYLKYQISRDRLDKQIRDLESAVEEMRDDVVNRHCHVNLAEVDALAQAIGNSSKHIAEQKVAFPVLADKMKAVMQGEMEIVVSEENFIKDEPGKLDDYMKRCKKVTNTLCTLKRLASVQEHRTPVVPVFEQTSQPVNREALMETIQSISPNHEQRVKNLQVAANESRERKRRFHTAQELHRFQMDIGRGRQTLRKTPNLERVDQQRRAALRKLYQSEEHDSLTPILTPEKMAKQEGSKGGKKKQPPPPPPKRTYLSQQAVASRSPATSPSSPGVPEPGPNPTPKPKLVVTSSEDSEAVPVVPPKPAMMMPKSKLPQQVDDPSSARSAPDLSCMNSTSSVNSECLSSPVRDLQPTCALSPSGCKSEPFLATSENAQSSMTNPRKVVLAAQRVGKPAADKSHQCVSGPVPGTVMTTQSAPMRSPRGQATPRSGQTSPRGATSPRGVVTPEGGIMLSQGAVMIAKSGSATSPGLATTPQRQAPVRLLSSSSQASPTKTNSPTSPQYKQSCIPVLKHSQHSRVQPPTTKVSETAVSNTHTQQTSPPSNPLPQRRSSVPSAMDVAPPPKPPRGCIDDPKEPTDAPPQSAFRPLAIPGWRETSLDEVPLKKSKVRRHTVTLPQHQKRNGWVAPVTDPPLNSSPQKPQPSQQTLLPVQQKSPVGRSVITNEPKAAPVKQGVLSKSQSGTDAELNPDRKPSLQRQNSDPGARPQVTIVDKKGALKIQQLKEQYAKLRKLQEEQKLLEQQSTRSSPSQPEATQQEQPPREATSTDLLDKIPPSTTLQVDVSYSQGESSKTEDQDEGSSYTKQTVVYRVGPKPFKSDEGKQSSVPLEELEKTTTVVSTKREVIADSIPVTNGMVHQPVFSQFKVHEMAPRNFATKAKPGVAQSPAAMVNGNGMEEKPSPKPNGGHAPTDTIKSSPVKGDVVTNGGGKLPLTNGGSEVAEGQGERVIERTEKEIKKFNAANVNQNGKPELKTVYTKRLEETFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZW0</accession>
    <name>A0A8B7XZW0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 184C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110976992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022086438.1">
        <property type="nucleotide sequence ID" value="XM_022230746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZW0"/>
    <dbReference type="GeneID" id="110976992"/>
    <dbReference type="KEGG" id="aplc:110976992"/>
    <dbReference type="OMA" id="PFAFATM"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086438.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="65663" checksum="67955AE3C36A551F" modified="2022-01-19" version="1">MEIDRDPSSVEQGQSTPTPLVQGDSSPRSCWANWRRWVRPAFYVAYALLVIATIPLIILDLVHAKKQNIQVTLAAVGFFAMVICIPISLWGIINHIVCYTRPDLQKYIIRILWIVPIYEVNCWFALRFPAAEIYLDTLRQLYQAYVIYNYVFYLLTFFEEVPNFKERLLAKPLIKSPAPCCCVKAVPNQRIINRCRNGVLNYTVIRIIFSGISLVTDLLGKFEEGNYSPNFAYLWVTICVTISQIWAIFCMVLLRKATLQELEMLPRSTAQFVGIQMVIFVSNFQSVILNLLAQFGVFERFEDPFAFATMLQDFLICLEMVLGAAVFSYSFDYQRYNTDSEHKMILSKSFKHMLNVSDVKNNIMDHLRFGGHTFQRNHSEAAAWAEQLSPSTPDSPTSIQDFFPPRDAVLRPRIKTSRKQKLTCQPDIVLNQQGRPDSPVDEMHTPDEQSGRKKQDGALQNRGFEYPEDQQVLDPQEDDVSGDMDDLIGEEFPVDDDDSDEDSHLPVDARLDKPPAAPHHRRVKKVSFSGMNFDDMDVDHIKNHRSPTMDSDSFVTKETEKGTTEGSEGFGSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y005</accession>
    <name>A0A8B7Y005_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110977031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086483.1">
        <property type="nucleotide sequence ID" value="XM_022230791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y005"/>
    <dbReference type="GeneID" id="110977031"/>
    <dbReference type="KEGG" id="aplc:110977031"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.20.20:FF:000003">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022086483.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26293" checksum="75CBD310FC257A18" modified="2022-01-19" version="1">MATAMQLRSVARSLLLPRLSASRLLRNNNQRIQWQSTETQEASKSDAKVTEKSAPTEGGKAEEKTDLSAAEKTLKEEKEKLQAQIAEITDKYKRALAETENVRTRYKRQLDDSKLYAIQGFCKDLLEVSDILDKAMGSVPEEELKRKENESLRSLYQGLQMTGTELQKVFNKHNLHRIDPLGQKFDPNLHEAMFEVPAEEGKNPSDVAVVTKIGYRLHSRTLRPALVGVVKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4G6</accession>
    <name>A0A8B7Y4G6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Uncharacterized protein LOC110977874 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15" type="primary">LOC110977874</name>
    </gene>
    <organism evidence="11 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088077.1">
        <property type="nucleotide sequence ID" value="XM_022232385.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088078.1">
        <property type="nucleotide sequence ID" value="XM_022232386.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088079.1">
        <property type="nucleotide sequence ID" value="XM_022232387.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088080.1">
        <property type="nucleotide sequence ID" value="XM_022232388.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977874"/>
    <dbReference type="KEGG" id="aplc:110977874"/>
    <dbReference type="OMA" id="HYENNDI"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
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    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
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    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
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    <dbReference type="Pfam" id="PF26588">
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    <dbReference type="Pfam" id="PF01825">
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        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665502" evidence="8">
        <location>
            <begin position="24"/>
            <end position="1403"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1063"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1093"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1122"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1161"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1203"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1253"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1301"/>
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        <location>
            <begin position="888"/>
            <end position="1051"/>
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        <location>
            <begin position="1057"/>
            <end position="1303"/>
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        <location>
            <begin position="1361"/>
            <end position="1403"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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            <dbReference type="RefSeq" id="XP_022088078.1"/>
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    <sequence length="1403" mass="152612" checksum="C64A48A07FA2FC0E" modified="2022-01-19" version="1">MKLLIFYVVPIAQLAWYLQQAHCTTCSYSCLQRYTTGCWFWSRCSMYRSSTCYRCCQGWSGSTASGCSTPICSPSCTNGGRCTAPDYCSNCNRGFYSPHCSRCSAISNCLDVYCNSATDQRCGACDGDYGTQFGSAYKLSADQRRCIKQCSWRTNSNACYPGSCTNGLCTCKSGFSGTDCRTLATSQRPTTSEYRGSLIKGTTTVESPAVQGSTTTVYTDVTNFTSIRVLWTTSYQPTGLPELPLYIQRVNLGIVSARVTVYAHLARGQLLHIGSRSCSSAGSPSNPASNLVVCEANFDIDYSSWSPSTGDVLRYTVYSSSGGHMKLFNRDSNSNILTRYYSSRQTSATATFTFALDGPSHCVGTTSCRNSMLSVESNVVTEPNITITWDDWTDSHAGIKEYNLEVRHLSGTSGDEMTEILVNPPVYGGVSESGQMVTLPSAGVYSVVLSVVDNVANVRRSRRFVFFDDDQNDVVVEPVSSMRLLSADGVTEYKWLTVSDWAPSQAPLVRLDWQGHFVNSKHVSQGLLKPIGPYTNGTIDADYDQYFGQRGREAIPNAGGVTEFRVLFDIDQTSGTTIVEPSIDNSDTWLNVGTDTNLIYTNQTSVRDGDSIRFWVEARDLAGHFSRDNLLIHVDSSPPVIEDVGLVVDLNSVSVKFRTFDKHSGLLAVEWRLFENQTSTVSSFGNETVTIVNMTENNASCSTTDCVCTPLGDCYATAYRFMPTVPSIVHDLNFVIKLTVTNQAGLVTNETVKLSVTAENVKKYSESLVSITNDTSSIDENSVLSAADLLDSIVGVQDTSPEVTENVVKTVNNLLQVDEGRLGTADEVANSSSRIVKSLGRQISNALAAGQNVSLVTSNLAVEARTFRPSTLERGVGFAAVKGENGTSYFDEDAVNVYESGQEVPVAEAAVSIQLPADIVNKSSEDDSIPVSFVVYQSSKLFRSGRTSNSSSTLPASFIESRVIAANVEGRRITNLPPDAPVVIAFLQDKLMSIPDRQTTECVFWDFDLRAGIGEWSSEGCRESSPVGGRTVCHCSHATNFAVLVNIHGPKHTSFALDVFSKIGSSLSIAGLSITIALYLAIRSLRTLKASRILISFCCSLLLLYLVFLAGIEQTSSRSGCIAAAVLMHYFALTSMAWMGVEAANLYLKLVKVFNSDVSHFFIKASLVAWGLPAVVIVIILAVDYRVYDSEDRCFLKPGTAFYVGQLLIIGLVFLFNLVVFALVFRKLTCVAGRVKGSPGESNRDMVARRLKAMVSVAVLLGLTWVFGLLSVWGTVSFAFQVLFCICNSLQGLFVFLLFVVRQEKVSEGLGNLRRGWRERPLDRSTANSRLTASKTSVIITKWSRKNDSVNSDGHENIAVATFEDAAHPQLTPPSGQGHTEAAPGHNKTDTPTTKEGSDAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y552</accession>
    <name>A0A8B7Y552_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977293</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_022231279.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977293"/>
    <dbReference type="KEGG" id="aplc:110977293"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086971.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="16781" checksum="9EC7F30A846100DD" modified="2022-01-19" version="1">MGLLVHFLELGERNFERMVMLGNYSVLPSYSAAAPLRLGMAGPTNSQSGGKPLNLSRANGTKISTPGRSCDTEQARSVEAGGCSDLPRPLATYKELIRDVDQGVCTEPGCSSDVSELPKGRPSTSITXLSRYDAPRLRRLSSKEPPPESIAGQSISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y650</accession>
    <name>A0A8B7Y650_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Potassium voltage-gated channel subfamily H member 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110978196</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088678.1">
        <property type="nucleotide sequence ID" value="XM_022232986.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000009">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000009">
        <property type="entry name" value="Potassium voltage-gated channel subfamily H member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000035">
        <property type="entry name" value="Potassium voltage-gated channel, subfamily H (Eag-related), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003949">
        <property type="entry name" value="K_chnl_volt-dep_EAG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050818">
        <property type="entry name" value="KCNH_animal-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217:SF435">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN EAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10217">
        <property type="entry name" value="VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01464">
        <property type="entry name" value="EAGCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="19">
        <location>
            <begin position="93"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="577"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="747"/>
            <end position="840"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="879"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
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            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
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            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="932"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="960"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
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            <begin position="984"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022088678.1"/>
        </source>
    </evidence>
    <sequence length="1029" mass="114899" checksum="F539F630C5AF08FB" modified="2022-01-19" version="1">MPTSRRGLVAPQNTFLESIIRRSAVQHSNFILSNARVVGYPIVYSNDGFCKMTGRTRADVMQKSSTCNFMYGDLTDKETIKKVEKAFEDQTPVQVELVIYKRNRTPMWSLLQIAPIQNEKDQIVLFLCTFKDITSLKQPIEDENAKGLSRFARLARTVTRSKSVLVQVAQHLPNMKSEQSTQNQISQIAHMMSIDAEVLPQYKREAPKTPPHIILHYCTFKIMWDWVILLLTFYTAVAVPLNVAFQTQTAKDYISMVVDGIVDIVFFIDVILNFHTTFVGPGGEVVSDPKVIRMNYLKSWFIIDLLSCLPYDVINAFQQQNQNLSSIFSALKVVRLLRLGRVVRKLDHYIEYGVAFLILLMLSYMLFAHWAACIWYSIGVSDARNNLTQGWLFKLSRDVGYPYSYDEEGNFDPDSGPPVTMKYISSLYYTMSSFTSVGFGNIAAVTVLEKVFTILMMVVGSLLYATIFGNVTTIFQQFTHNTARYHDMLNNVKEFMKLHQVDKSLSERVMDYVVSSWSINKGIDSEKVLSYCPKDMKADVCVHLNRSVFSEHAGFRLASEGCLRALAINFTMSHSAPGDLLIHVGESVDSLWFVVSGSLEVIQDEEVVAILGAGDVYGDAFWKDNSLGQAAANVKALTYCDLHSIRRDDLMDVLNFYQAFANSFARNMVLTYNLRHRLVFRKVADVKREQAEAEKRKNEPPIPADHPVRKMLNKFRKLSDVPEKRTAGAGNDVEKGENDIGSLSVLARMKGPMLTRVPESNDTSKMNRTAKHRPTAPKEAAPAQTAKPASKWGALKNPNQLRKTESTDSGILRSDQKLDEIGRHDSKEGTSSMSTSSTDQQLLTSLMEIKLELKEEIEHLSVKMNRLDEQIGDIIKFFSPESSPYSSSVPSSNSSRVSSMNEVAIASPQKSPITVKVREHADTFTVSSPPASGLGSKSVTGSGSSGTSNEKKRSADRRNSNGSRSSAGSRHSSSSEARRTGTPTSPPDTRGPPPVESTNILALLDPDLQRESFTDIESPPSPDAHVPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6F3</accession>
    <name>A0A8B7Y6F3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Endothelial zinc finger protein induced by tumor necrosis factor alpha-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC110978258</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088788.1">
        <property type="nucleotide sequence ID" value="XM_022233096.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088789.1">
        <property type="nucleotide sequence ID" value="XM_022233097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6F3"/>
    <dbReference type="GeneID" id="110978258"/>
    <dbReference type="KEGG" id="aplc:110978258"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001111">
        <property type="entry name" value="Zinc finger protein 92 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF196">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="688"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="716"/>
            <end position="744"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="745"/>
            <end position="772"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="312"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022088788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022088789.1"/>
        </source>
    </evidence>
    <sequence length="799" mass="90923" checksum="D71B933E305541F1" modified="2022-01-19" version="1">MAALWNCDSQAKLLNFQGNGERSDPQTTRLSETEEEICQQTTNSNTLSTEMTKSAQQVCELPMNVVKFEKDKTSNTVPNSLQVQEADISVRAQSHHRESNNEQGKALKTSRTQDKPEKMQGNSKALSVSKKGNKGVFGCQFCNRSFSNSGHCRDHERTHTGERPFACPTCGRAFATNSTLTVHQRVHTGEKPYVFDTCGKAFSQITPIRKQKCCGKGIERNFACQFCEKTFSNSGHLREHERIHTGEKPFVCGTCGKGYTSKSNLKVHERVHSGAKPYVCDICDRAFSQRGNLKKHMGRCVSTKKCTSDEELFQPVSQTRQDEKTAQSDEPGSPASPASSLDSQDTDSSNSHKDKFGGGNLTMHQSKRTAGTNPPMNDQNAQSSDRPFICEICNKSFKFDRNLKDHKRIHSDKRPFFCDYCNKTFKLKSCLTAHRRIHTGEKLFSCDICDEKFMYLNRLQVHQMYHENRRPFACQFCSKGFTTKSHVKEHERIHTGERPFVCDICNNSFKTRGVLRTHKIIHSQTRKICKAASVMKKGNQRAFACQFCKKSSSNSGHLREHERTHTGERPFVCEICGKAFSAKSTLTLHIKVHSRKKFHCGNCGQTFAGQAEFRVHQVIHAKPKQYVCKTCSEAFQSKDKLKEHSKLHKTSEKGCKEKKYICETCGKAYGKYSHLWEHRQTHTDKKSHLCHICGDVFRKPHHLKRHQIVHTKEKEHICEICGTGFGHRHTLKSHHLQVHTNHRPFKCGTCGKGFIKRYALVSHQRVHTGEKPYVCGVCDRAFSHNITLRKHKCGSSWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6W1</accession>
    <name>A0A8B7Y6W1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110978001 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110978001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088302.1">
        <property type="nucleotide sequence ID" value="XM_022232610.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978001"/>
    <dbReference type="KEGG" id="aplc:110978001"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13248">
        <property type="entry name" value="PH_PEPP1_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040392">
        <property type="entry name" value="PKHA4-7_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057971">
        <property type="entry name" value="PKHA4-7_TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752:SF9">
        <property type="entry name" value="KRAMER, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12752">
        <property type="entry name" value="PHOSPHOINOSITOL 3-PHOSPHATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25541">
        <property type="entry name" value="TBCA_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="190"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1586"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1636"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1678"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1926"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2098"/>
            <end position="2118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1462"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2166"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="738"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="897"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="939"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1148"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1678"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1698"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1712"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1742"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1762"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1811"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1960"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2109"/>
            <end position="2118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022088302.1"/>
        </source>
    </evidence>
    <sequence length="2218" mass="253604" checksum="0A645938A4DC1971" modified="2022-01-19" version="1">MAERLRRDPLPPQWSYGVKSDGRIFFINEETRSTTWLHPVTGKAISTGYSDRDDLPPGWQEGITREGVAYFMNHHTGETTFNHPITHKPEADDEFFLIDRTQETPPYHRPKLAPLQMTPNNPAQSNPSRYATSPSSDPASPSYATTAATPNQPTTPTSPTTPISSERPSFRKRIVPKESAPALKRRRDAVATMEGWLFKQDSGALKAWRKRWCVLADYCLFYYKGSDKTRSESGSILLPSYQISPVGPQDKITRKYAFKCEHENMRTYYFAAENQVDMNQWIRAMKLAANAQLERRQQYDDDDARFRGHHSQSPDDERDNEEWLFRSPKELNGTMREDYEDNPHVAQHQNGFDPDGRLPREPEEANDHHFRNGDDYYTEDAPEGYWEARERYVQNNGRYPEKNRGHGPSALERANPPAIYDYPPDEDIDGYSSPEEGKQELRERFRDEEEEAGDDDEKAHQSQSDSERVDDKELSDREEFGMDRGRDPHSGHDDRRKFHHDDDEKPGERSRYNSRGSGDRPPQPGALHPPSDMDAGGYATLRLPQQQDGQEPSERLEDPPRRDRYSSLSESDQDRQIIPTEERLVSSVAPMHEAGYHPRERPGSGQRRKDPNSASPEDDRGTARSRDSQSSRASQDRHGGRRGDRHGGDPRRSWDRGSGSVSSRDDGQRPGRSIGGGRRGNGPAPHSPGQYPESYNTLPRPRSKSRERSSTEEGQFPESSRNSNKGGSLDRHQMPHYDSSTTDSLPSPSGEPTSHPLGGGGRRPPYDDPRRMHSLDQRHQRPRRDSDSQSDSRHSSRGERSPAPQGYWDREGRRRDPREMQGTRSLDRDRRPQPQRSSTDSLPREGHQRATLPPDYRSPDARRHNFAEHHPLAQDLPDSDISKVSTPPGSAPGSVDGRMRVDPETGSLRRDDRRGDPRRSDPRGDPRRDDLRGGNPLSDPRHNRRSDPRGDPRQRDPRGDPRRDARLDQRSDLRWGDPHRGYSSLDRPDDPRQHDPRGQPRRADPRDDPRRGDPRGDPRRDDSRDGPRRRDPRDDPRRGDPRQSDPRRGGPRGDHRVDRRSDPQRGRPGEDGRREMQGRRPPEPLHFKFPKTGEIYPSEVTPEQRSLLQSPLAQPGHDPWTPEQRADINSPLAYPRNEPEWPTSRPEAYYRARERQAESDRDMSAQHSAERQPLSDYVPQQVEAVIQRSAPTNETFASAPPLPSEERYPEEQRPANYDRPRRFASSITEEGVEGTTEADIAPRRARNANSKRRSERNTLERNEFNSGDQLAPLAGSSGSNKGPREPTSRFKKWQMKAQPYILLSTGIRLRLSIAAGDLLGKSHEELVLLLIQLRRDQSNLKRWLEMIDQELALLADPASSPPGSPTRMRARHSDSLHRRSNPNLSEDREFLEELSLERVEVERELEISRPLVRLVDNLVRMGSLYGGQNQMIAQEFYRDKVQKDLNYIEPKKLIEFSRRLEEEKLNRDLKGELQQIQTAEDRLLEEKLSQLHRLDKRLQEMSAHVSLLKEDKDKIEASLDRLGRQMDRHWDEPDIRVGMEDQQHRLERDLVKVRTQLANGTKELEEVAAENGKIEYEVSLLRSKLDAQHQRSTKSPHEGANTKERLQMENEVTRVQSLLENLDKQRNQLANQMQTLRTGPAETYPEKIQRHRREQSPRTPKQYAVTDLDTMLSHDISASPATPAAASDSGWKSAPPLRRREDSIKKVRQIKEQQVQQSPVLESVASSTAQSSYHASPQILHPQPRYQQPPMQQMEQPQIYPNQENQYYSSPSTNHRRGRAPPQERVRNGPSQQGWYGDGNPANKRHTIGGYEKRSKGPRPESKYHTISRTGEIIPGSPMRRTRSVPDQQGLMAGDDRKSSAMDRLMPGIPYKNTSYDPYHGAVSDTEADPAASRAKKKSQSLRASDGAQLKAQAPALRLLRSARSQTLPGRFTDGPQTPPVFDNDPLMTPDLTNSWDEGTTNRDGDERRWPPPEPNRRHTFSGHPLGPQARPFAKGVQDDIAIHELQKALIDPDEVQELDILEPSGPRPSDIISGKYKPVEVDESTGGGLSYAHLAFVPHTYFQAKRKLLREWFFASTESTPPQLGLPAKIIIPERYLPDDDDEPAMTQEERERHEERVDRITKMLSAHRLSEHGITLENDMSSLQEWHPSEILSTWDKAGEFPEAEELRLKVEEEKQARQEVLAMRRALAQEVKEQSKVMAARSMRMNTDGQQIAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7M4</accession>
    <name>A0A8B7Y7M4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="14">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Twinkle protein, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 21 22 23 24" type="primary">LOC110978490</name>
    </gene>
    <organism evidence="19 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022089219.1">
        <property type="nucleotide sequence ID" value="XM_022233527.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089220.1">
        <property type="nucleotide sequence ID" value="XM_022233528.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089222.1">
        <property type="nucleotide sequence ID" value="XM_022233530.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089223.1">
        <property type="nucleotide sequence ID" value="XM_022233531.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089224.1">
        <property type="nucleotide sequence ID" value="XM_022233532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7M4"/>
    <dbReference type="GeneID" id="110978490"/>
    <dbReference type="KEGG" id="aplc:110978490"/>
    <dbReference type="CTD" id="56652"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01122">
        <property type="entry name" value="Twinkle_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000845">
        <property type="entry name" value="Mitochondrial helicase twinkle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027032">
        <property type="entry name" value="Twinkle-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873">
        <property type="entry name" value="T7-LIKE MITOCHONDRIAL DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12873:SF0">
        <property type="entry name" value="TWINKLE MTDNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13481">
        <property type="entry name" value="AAA_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56731">
        <property type="entry name" value="DNA primase core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SF4 helicase" evidence="18">
        <location>
            <begin position="522"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022089219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022089220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022089222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022089223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022089224.1"/>
        </source>
    </evidence>
    <sequence length="817" mass="91631" checksum="182FBEB5373EDFD8" modified="2022-01-19" version="1">MCSAKMQQLSRVKSSLSLQPQSCLKSFTDWVGAVVAMTAAISGNQRHNNMHPCTMKGTAVCKTYNAFVCSKKSLLLGWRRYSARLKYTKAKNFSKLVHSKTVLPIAPGRTSTVLSGRAIRVGKSSSMLHDYCAGSILSPSNTQRLASPKPWTSPPRQGCIPDRTLSTSSTSAPTRTTFNSVEEVQVPTLTDMKRHLKNAEIDFQTGYTCLMAACPFCRAASADSHRRDAQTMYINMTTGHCVCQCTRVSGSWQSLQDSMAVAQQRGCPDPSSFPNPTATADEGDVRGHRLGLARVQEVWEGAMELSLCKGATIDRLRATMGIEQIPRDTLEQFNIKYCKKQRAFVLPLYGHNKQLQGVKVLEVKKVKEGFEVAEMLYPRRDQSGLFGYHLIGPRDGEMVLVAGVLDALAVHQMTGGTVLALPNGSASLQQELLPLLEQFHKITLWFGNDMRSWEAAKQFARKLNTKRCYFIRPLDCHPPALVALQQGLSLGSILKQANPVSHKSIVSFRSLREEVLGELSHSEQVAGVKWKRFPLMNKLLKGHRRGELSVFTGPTGSGKTTFMAEYSLDLCTQGVNTLWGSFEIQNVRLAKVMLTQFAQVNLEKNLDKFDKWADKFEMLPLYFMTFHGQQTLKAVIEAMSHAVYVHDIEHVIVDNLQFMVGYSDKQFMLERFAMYDHIIAAFRKFATNNNCHVTVVIHPRKENASEELQTASIFGSAKASQEADNVFILQDRRLTALRGRKYIQIVKNRFDGDLGIMPLYFNKETRTMSPPSKLRNKKAYSGKLLKLGETNELEDSYELFEELMLINKQEDELGRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8C5</accession>
    <name>A0A8B7Y8C5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase TRIM56-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110977837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088006.1">
        <property type="nucleotide sequence ID" value="XM_022232314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8C5"/>
    <dbReference type="GeneID" id="110977837"/>
    <dbReference type="KEGG" id="aplc:110977837"/>
    <dbReference type="OMA" id="QNEMARG"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="603"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022088006.1"/>
        </source>
    </evidence>
    <sequence length="659" mass="71784" checksum="87BFBBDE56EB7530" modified="2022-01-19" version="1">MEKEKSDPLLCFLCNNKFKRPKILNCLHSYCEKCLQRMQKSSKLARKDIRCPVCREATPVENGVEGIKTNFFLGRLVEDAVVSEILWSKSAIASCELCEREAVCRCYDCARFLCSCCRAIHDRLPASSEHGVWSLDECRRAGATPASGTGRDCPPECSGHAGERCRFYCLSCQKLICRDCTVLDHSSQKSHNYTSLESAACEEKRTTGALVVRLEKKIPQLEAALEVLTEMGPVLKSQNEMARGLVQAAANKIRESVTEAEKRLLREIRLESRQQEKELRENKKEVVALLDDCRFSHDASKFFVQKSKASEFLWLNSILTKKLHDLVAKEAPVGPSAVRFKERDTDISLGTLTKEDITEAVSKEVAQRKLKGKENSSFKKAPRKVSAVQSKEPAVPANKENQHHGPGECGDSEEEISGSSQPCESDEPSTSIKTATSTGHDAPDGKMQSKSSPSGLKTSSADAGARRTKDAIPPSDRVLRSSSKANASQNQAIPRPTQHQQPRASIDPVQGSLTQDVVDGPARRPTIRSKTQGQSGDRLNPSLSAAGSAKGFTTLQNRQPPAQPPSQHKPQHLTHAASATQAKSEPFQDFKFSGDLSAAQLLSSMQQGKAVATSEDGSSTHPHRDGAQAPAGMYAPEGNSQGVNGSDNENDTDSDGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8Y3</accession>
    <name>A0A8B7Y8Y3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC110978367 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110978367</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089001.1">
        <property type="nucleotide sequence ID" value="XM_022233309.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089002.1">
        <property type="nucleotide sequence ID" value="XM_022233310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8Y3"/>
    <dbReference type="GeneID" id="110978367"/>
    <dbReference type="KEGG" id="aplc:110978367"/>
    <dbReference type="OMA" id="LTHDEDA"/>
    <dbReference type="OrthoDB" id="10462046at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665528" evidence="3">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022089001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022089002.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="38074" checksum="911D9036FF176CCF" modified="2022-01-19" version="1">MLQWVNDVLLLLVSVLSLDKLVDYANQSRVFLIYDILLRRKPSLANRLGLTHDIDAQANELVSMTIQAQETRRDEAFLRDQMFHLNRRLRRFKIRESVALIKCRAWQERKQFLLREKDKQDKQIQEQRKSMQQQWANHCDEMKSLKQTLSDTLREKAEMESEVGSLQDEIKSLEKALKAKSQGVENLKIVRSAISEEVEHSKAQLENTKRRLEAIDASHSRFMVQRRKTLKALKARAAKVRFKADQVELICYMQEKVNQVTRMRVDSLREHLDRLHVDLVPQSEVILIEQRRYKLVKILKRMCMVLLIEGLVYLVYFLITSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBF6</accession>
    <name>A0A8B7YBF6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Echinoidin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110978874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089887.1">
        <property type="nucleotide sequence ID" value="XM_022234195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBF6"/>
    <dbReference type="GeneID" id="110978874"/>
    <dbReference type="KEGG" id="aplc:110978874"/>
    <dbReference type="OMA" id="WRSSKIV"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034015739" evidence="1">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="39"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022089887.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21154" checksum="2435A3BA75E19694" modified="2022-01-19" version="1">MNKIVPTLLLKAFLVTSSLAYYGTPPTTDSTCPVFFTGFGDSCYRFFGDALPWREAEARCQRYFSPVGTQGHLASIHSYAENAFVYELWRSSKIVPSDMISNYNRFDSVWIGMNDLEVEGNYRWSDGSAVKYRKWADAEPNDTIAKDDCVHMMDILGRGVPGEWNDIDCNHDNGLPFICKLKLTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBM6</accession>
    <name>A0A8B7YBM6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Cytochrome P450 2J6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110978812</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089789.1">
        <property type="nucleotide sequence ID" value="XM_022234097.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089790.1">
        <property type="nucleotide sequence ID" value="XM_022234098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBM6"/>
    <dbReference type="GeneID" id="110978812"/>
    <dbReference type="KEGG" id="aplc:110978812"/>
    <dbReference type="OMA" id="QPFEICA"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022089789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022089790.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="56247" checksum="E826F4C545C66A28" modified="2022-01-19" version="1">MNSWWVPSLSVTATDTTAVLIGVAVFIIVRWLCRRPANLPPGPLALPLVGSLPSLLFYSGAPHEIFHRLSQRYGPVVNIDLIFGRRVVVLHGYDVIKDAFRHYPQLNGRPSLSVFEKVLKGGVGVVGASGDLWRAQRRITLHFMRDFGLNKPHFEDRISTEARHLLEAIRAHRGCPFNPSHILSSALANVICLVVFGSRYEYTDPRFVELLRAIYRNLELMGGATGAILFMPYSHLLAKFVPVVRECLDNTQYVCDFSRAALEDHREDFDPGNLRDFMDVIIREMTCTKSGVTVNDLHGTTADLFAAGTETSAVTLQWALLYMVACPQVQARVQQELDRVVGRSRFPRLSDRNRLPYAVATLQEVQRIGNIIPLGVPHEASGDVTFRQHHIPKGTLVLPNLWALGTDPTLWPEPHVFNPDRFLDEHHEVLKPDELLPFCIGRRSCVGEQLAKMELFLFFTHLLHRFTFEKPEGSPALSFRGVGGISLSPQPFEICAIPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBY4</accession>
    <name>A0A8B7YBY4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Interleukin-17F-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110978870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089885.1">
        <property type="nucleotide sequence ID" value="XM_022234193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBY4"/>
    <dbReference type="GeneID" id="110978870"/>
    <dbReference type="KEGG" id="aplc:110978870"/>
    <dbReference type="OMA" id="RSATCPW"/>
    <dbReference type="OrthoDB" id="10070312at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034057843" evidence="5">
        <location>
            <begin position="29"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022089885.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19466" checksum="2897C5BFDE31FB45" modified="2022-01-19" version="1">MTSSLKNVKKATLLSLLVTLLIVYGTVANPIGSSQVCPSSPLTLFGQDTSTLPQAAHQAPETNQTCPSGDRVQSHWPTSRSATCPWRYETDYDADRFPSTLTQAVCSCAQEGCLNPYTNEPEPDLECTPVMYSVPVMRRRDCVDGVADVYQDVESVTVACVCLRPVSHAIRAPGIIGLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCC2</accession>
    <name>A0A8B7YCC2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14" type="primary">LOC110979425</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022090891.1">
        <property type="nucleotide sequence ID" value="XM_022235199.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090892.1">
        <property type="nucleotide sequence ID" value="XM_022235200.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090893.1">
        <property type="nucleotide sequence ID" value="XM_022235201.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090894.1">
        <property type="nucleotide sequence ID" value="XM_022235202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCC2"/>
    <dbReference type="GeneID" id="110979425"/>
    <dbReference type="KEGG" id="aplc:110979425"/>
    <dbReference type="OMA" id="WQLWSSA"/>
    <dbReference type="OrthoDB" id="6057829at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000008">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000013">
        <property type="entry name" value="Apoptosis-resistant E3 ubiquitin protein ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058738">
        <property type="entry name" value="PH-like_AREL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF340">
        <property type="entry name" value="APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25916">
        <property type="entry name" value="AREL1_PH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="241"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="632"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022090891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022090892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022090893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022090894.1"/>
        </source>
    </evidence>
    <sequence length="972" mass="111017" checksum="822D1A19917ADF60" modified="2022-01-19" version="1">MAVKTHWWPCFVGVVLLAIVLGLATVHWQKQSEFDSFIKEHGLTHYESTFSSAGVSYLEQFASPDLLEHEVFEKLSAAGRNKIHQVSEKLASSLLLFQWLDSRQLQHHHGDVQAWLDKHKQKRHRGSHFGYTSVRQLAMLTQEEISHLITYLKTTEFETYLLREGIKELAVEDSWRQLILNPTFSSVQKMKDFFIFDRLLILTMPLGLLCFWVWGNYQLARGIPQQQGRERPSSILNYITGSLLDVNCCKVEWGWAEPAIVGETMSFVIKFFQRNRRPYIINRDNSLPVIIEITVSQQRVACSLEYGTINEVKASFTVRRAGLYTITVRLGQMNIRGSPYRMNFLPGPVDPSKSAFVRHSSTMVVTRGHMCPLFIEPRDQFGNPCLTSLDTNRGDRNKTDDYCLQVTEIGSDTFDSKKPHYEVKPSQDRQLALRVRMETTGCYKALVTYRKEKLSNGEFNILVLSENDAEKVKKNLDKKSTEGYEATLLTHNNAKQRRPKKVYCYISPKQLTVKEFYLRIIPKRLQTFRVCPATKFNFSKDQAEQEVPVFSVEDGCQPPMQLASKHRDVMAATFTKFLLTNIGGSETFQDKQRCFHREVVSLKPRKHHSVVTLNIDRHSLLESSMKATKPFSTSDWCKKFEISFLGEEGQDWGGLGREWTELVCTALFAPENKFFKRFRDNNQGLVHPNPERPPHLCKTKYYEFAGKVVGKCLYESSLGSVTRQLVKARFSRSFLAQLIGLRVSHKYFETDDPDFYTTKVRFILDNDVNDMGLTFSEEVYSKGGQLAQEVDLIPGGASTPVTNDNKTEYLDKLAQHRLANNVQEEIEAFLKGLNDLIPDQLLSMFDENELELLMCGTCAFSVTDMQRHYIPSGQGEQFGQMLDWFWTVVASFTQEEMARLLQFTTGCSQLPPGGFAELSPKFQVIAAPTHGTLPTAHTCFNQLCLPTYDSIEHLQKALVLAINEGGEGFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCF5</accession>
    <name>A0A8B7YCF5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sorting nexin-29-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110978567</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089361.1">
        <property type="nucleotide sequence ID" value="XM_022233669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCF5"/>
    <dbReference type="GeneID" id="110978567"/>
    <dbReference type="KEGG" id="aplc:110978567"/>
    <dbReference type="CTD" id="92017"/>
    <dbReference type="OMA" id="TIPHVKL"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07277">
        <property type="entry name" value="PX_RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17689">
        <property type="entry name" value="RUN_SNX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004012">
        <property type="entry name" value="Run_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037213">
        <property type="entry name" value="Run_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047329">
        <property type="entry name" value="RUN_SNX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037916">
        <property type="entry name" value="SNX29_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47194:SF3">
        <property type="entry name" value="SORTING NEXIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47194">
        <property type="entry name" value="SORTING NEXIN-29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="4">
        <location>
            <begin position="34"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="804"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="927"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022089361.1"/>
        </source>
    </evidence>
    <sequence length="956" mass="106307" checksum="C48A62B54A552A39" modified="2022-01-19" version="1">MEHLPQERQHLLDRLLDAVKQCQVRFGGRTELATDSDSRVSCLCAQFEAVLMHGLKRGTSNPLTALKQMTGIPLIKPDAEQAFWPVIRENLTKHELQRYMSLKHITTDAGRARAWLRSTLNERSLERYLHSILATQGMLKQYYEPWAFLLDEERSSMIPTMARGLGSILFAINIDKDELNGTKQGPSLSSLIQAPEVVHSESMIQQDPEPVYVTATTTGATSDRKEKKKKKKKSFVSIVSFNDDDSGSTVVSCGSPPSRLHHHPRPRKDSAGNKDSLPKEAGQNNVSKKTVGFNVPSGQVQTMSDTSAGLPEVRLGPDLSQPSAQPLSNSTNHAHLQSLPGRGATVSNESLPNLPASVASIPREDSDKELANSSRYLPQVAEASQSIHGLAQPSQPIPVQIRATQNAQAPSQIPSQSTTANIPRQQDNGNNPDNGSLINQTVQQLATSFPAKTPPPTPDNAAFIQQYDHMRATVDAESVADRLRQQEIFPKTGSESSSFDADTVEGTPPKGLEVADNAQLRSIPSRQSFHIIGGGDDDSEVAMYPVNEDSASQQDTQSTDSSMLGFGAETENAALGLLLAQKSLKESIQSTMDPGTPEDTLSSYQTMSNDELKQAVLAMMNRNDDLQEQNRSLRSLLDSEMEHTGTIRAQLEELKCHSVEMEEKLLTQLGALTRENEVLKHQLKKYVGAVQMLRRDGSQAIEGLPGIRATEPQPPIPEPKLGLKQSDQVEEYERKLIQVAEMHGELMEFNDYLSRQLKQRDNLVRRLQDELVDLRGPLPRDQTAAVGLLNSGSDSDSLSSNQRALVNIWIPSAFLRGRGSEAYHVYQIYVRIRDEEWNVYRRYTEFRELHLRIRKNHAIVNTFDFPPKKAVGNKDSKFVEERRKKLQHYIRCVVNFFVDNSSELTENPCKEKLLSVLPFFKDEPTRKQTRPASASRSNKLVAGRQAVPETPTYDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCY0</accession>
    <name>A0A8B7YCY0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110979538</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091108.1">
        <property type="nucleotide sequence ID" value="XM_022235416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCY0"/>
    <dbReference type="GeneID" id="110979538"/>
    <dbReference type="KEGG" id="aplc:110979538"/>
    <dbReference type="OMA" id="TALQMFC"/>
    <dbReference type="OrthoDB" id="10034606at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030719">
        <property type="term" value="P:P granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09972">
        <property type="entry name" value="LOTUS_TDRD_OSKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="HTH OST-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="881"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="853"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091108.1"/>
        </source>
    </evidence>
    <sequence length="1215" mass="133468" checksum="B6555BF695A33AE8" modified="2022-01-19" version="1">MASASKLEMVNRTLRGVLLSEKGGVAINRVQGDYRDFTGTSLPFKEFGYASLEAFLRSIPNVVSLHRGPDGVVLCKCVTDDSTQRIGSLVNRQKGKKKGKGSGITAKPGRPNARLAKPVYQSNPSHKPRPIRPKFQASKQAPQQVRFLKQQNYARPGQQSINWVSSGPPKQTPPTKQLSTKPTNSSFSANSSKPKQHSASIVYQSAASSNEAALTTQQPAPRPWSGKLGAKRNKQLASSTLADNLQGQPDEAANQTGQSATYENIYITVENDSFQKDRSGNRPKTKFAKGKKQEWSANFDVPPRFKKLMSPTTGVQDHYDNQDGEPNKTSAPVVHTSPSGNFSGDVQIDRTTSDWIQKVLKEKPNGIWASALCDMHKKVFDQTLDPGVIGTMAQHNLIQRESIMGSVILYPKLTVCLGDSSVSKTTQRSVTLGPRDYPEVGGAAEKENQTGNGSLWSYPKAEPYEIPLLAELTHPTAFPNRQDSSPADLSMTSILQAVCQRQNVQLNYKTDYVILHGNSYHVVRCTAGPQVGIAYGVTEKAAMEGASANVLYRWNIMPGELPQAVTGCEELYLRVEHQAGLCNCTLVERDDGCKVPKCVASWLKRRSWKPSDDWVDQQNQRLVPTVSVARRTAHLTQDERLEARAARFCLKTTPEEEESSKAAPLMSLSFSPRRVERFCVFNSKTLQQLQDGKHSSQVPKNDCIPSKLSSTREVSVDLEAAWKTDQSFPDVQEHRTGLNSSSVATQDEILKLRAERIGLTLHGYTHSRGDMQSTPTATTGETDDNLKLARGIQSDMATAPSQRALDLEIRQVLRETFGRTAIYETVKDLGSGKHPLVSVCFIAGSVIGVGKGRSKLEARKAALKELLMNQRQLKMKLETKRLKKVDQEEMPNLPAQTPESVSRIGKDDVSASQPKNLTQIGGQNDTNLPCGQGFTRWQQKVAPAPGCPRRSSDSLSPRTASPGVSLPGGNPSAPDDQLPRNTPPQDSDAAGITHSLVGVRLAETQSLASASTEETSSEPRGGLVLSNLEVPGVPSLQLPEENEWDVYVAYITSLSDFWVILIGDEYSEQLIILEEEMRTFYQCCTWTLTEPPEAGDCYAAEFNREWLRVEVKSVEGDKVQCFLLDHGDLETADITSLRPLSETFLQLPFQVVRCKLTGCEQVANDDQTALQMFCQLALGKSLLAEITSRDGDCIVMELFDDSDVSVLEQCMTAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDB0</accession>
    <name>A0A8B7YDB0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin domain-containing protein 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091243.1">
        <property type="nucleotide sequence ID" value="XM_022235551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDB0"/>
    <dbReference type="GeneID" id="110979595"/>
    <dbReference type="KEGG" id="aplc:110979595"/>
    <dbReference type="OMA" id="GTIPAHR"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="211"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091243.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="47106" checksum="9645C8925285C601" modified="2022-01-19" version="1">MGILRDLEIVYDSNRDVFSQGDIVKGWAIVDVQTDEEMGLKNVQGISMQFKGKAKIVWITKDQQNLRSGHPDYRLEYIQGPSQRQWQDGTSTYERHQASEVYFNNTLVLFGSGQKDSGTQDLTLPSGRHNFPFQFQLPKTDLPASFEGLNGYVRYKTKVVVAIPKSLKNKKYKTEKHFTVLGPDVDLNLIPSIQEPMTIDNEIRNFCGCGPDIEAVVSVGLSKQGYVPGESIYVNGQVDNRDLSEHRDFTVYLVQKISYQDKRATRETAKKVLAKEKSTVACPRGRVSDYKVGPLPIPPVPSSDLAGCNLINIDYFVQCKDRTHSAKFPITVGSVPLWTHPTSDQGAPLENQGVQNTECPYLPPPRYEQVTGEMQRIRRRNMDEYFSEDQLFLPRYPYFDFAATGDLENMEPTLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE44</accession>
    <name>A0A8B7YE44_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Maltase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110979778</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091523.1">
        <property type="nucleotide sequence ID" value="XM_022235831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE44"/>
    <dbReference type="GeneID" id="110979778"/>
    <dbReference type="KEGG" id="aplc:110979778"/>
    <dbReference type="OMA" id="WEFPNDE"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000016">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="144"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="9">
        <location>
            <begin position="505"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022091523.1"/>
        </source>
    </evidence>
    <sequence length="724" mass="81280" checksum="151735A1EB1DD70C" modified="2022-01-19" version="1">MRVIRNDTDTVLIDTSLGGLVYSNQFLQFATKLPANSELYGFGEHEHHSLRHNMNWQTMGMYSRDQPPTTNGNLYGVHPFYMVIEEDFNTHGVLILNSNAQDVTLSPAPYLVYRTIGGVLDFYVFLGPTPENVVQQYTEAIGRPFIPPYWSLGFQLCRYGYNSLDAVKETVNRMQRYSIPHDVQYGDIDYMDEQRDFTYDTVSYSGLPEYVLELKSQGMHYIIILDPCIGNDLPPGQYGAYDSGNAKNVWITESDCITPAVGKVWPPENSVFPDYTNPATGDWWKDECVKFHNVIEYDGLWIDMNEPANFVTGSVTGCTNNKWNNPPYLPKIFGNVLADKSMCPDACQHLGKHYDLHNLFGWSQSIQTVPAARAATANRSIVISRSTFPGSGKYSGHWLGDNYSQWSNLHYSIIGSLEFNMFGIPYIGADICGFNGNSNDKMCQRWMQLGAFYTFSRNHNGLGYTEQDPAAFGDEVARVSREILEVRYTLLPYLYTLFYEAHALGSTVMRPLMHEFVSDEETHGIDRQFLWGPALLITPVLDEGFVTVEGYFPDCRWYDYYTGAEMASSSRGTYVTLSAPMDYIPLHVRGGYIMATQEPDVNTVKSRTKPMGLIVALDDNSEAHGTLFWDDGDSIDTYEKGEYFFAEFTTTIGSLTGTIKTNGYSGVSGLLWGSVRLMGVPSPATSVTVNGLAHTDFSYNSSTKELKINNAGVTVLIPLSITWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEK8</accession>
    <name>A0A8B7YEK8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Membrane-spanning 4-domains subfamily A member 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110979868</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091683.1">
        <property type="nucleotide sequence ID" value="XM_022235991.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091684.1">
        <property type="nucleotide sequence ID" value="XM_022235992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEK8"/>
    <dbReference type="GeneID" id="110979868"/>
    <dbReference type="KEGG" id="aplc:110979868"/>
    <dbReference type="OMA" id="YIGAPIW"/>
    <dbReference type="OrthoDB" id="10042560at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF158">
        <property type="entry name" value="CREB-BINDING PROTEIN-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022091684.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="32661" checksum="7AF1BFBD6AD57F46" modified="2022-01-19" version="1">MEHQAHAAMLNPNSNSSLPNEPSPVHQPNTGVSSVTSSQGAPCPAGPPMVSQQYMVMIQNATGVTPDFNVRGAYMTAHLQIICGALSVILGIIAILIESEDAYIGAPIWTGIFFFMSAGLTGEFAAKKRHNCLITGYLVLSVLSSVAAFQLLSLMASFTAWEFGTFYSSRIRARVAVDALTAVVALLELGISIVAAVISCRGTCCQTASGPSMTVQYMPAVPNGGTNILQNEQGGFVQGQPIQVTTCSPGQVACQLQACPVPQPSPPPRPHAQQHEAYPSLYPSMEDSGNQLEDTENDHVTGMEKVPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFW7</accession>
    <name>A0A8B7YFW7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110979240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022090546.1">
        <property type="nucleotide sequence ID" value="XM_022234854.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979240"/>
    <dbReference type="KEGG" id="aplc:110979240"/>
    <dbReference type="OMA" id="AHWAEPK"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000013">
        <property type="entry name" value="lactase-phlorizin hydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1472"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="923"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="1372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022090546.1"/>
        </source>
    </evidence>
    <sequence length="1491" mass="169114" checksum="B023C2033ABF9E48" modified="2022-01-19" version="1">MLGSAKAEEKIEFVYPDVFNDPERDTFLYGTFPKGFVWSSATSSYQIEGAWNVADKGVGIWDTFTHQGGKVFNNDTGDVACDSYHKYKEDVALMKAMGLHYYRFSISWPRLMPDGTAASLSADGVRYYNALINELIASDITPMVTLYHWDLPQALQDQGGWENETIVDRFNDYARACFQNFGDRVKLWITFNEPWIVSVHGYGNGVFAPGIAEPASKVYTTTHYLILSHAHAYHTYSTEFKATQNGQVGITLNSDYAEPADRSKPADIEAADTSLKFHFGWFAHPIYKNGDYPEIMKTNIAQKSAYQGFSKSRLPEFTTEQKAFIKDTGDFIGLNHYTSYYATSDTPDDSQASKASYWNDMNVRSWKDTKWPASGSSWLKIVPWGVRRLLKWISDEYGSDKPIYITENGVSTKDVYELEDTIRVNFYKSYINEVLKAIELDKVNVKSYTAWSLMDNFEWASGYSERFGMHYVDFNDPERPRTQKASARFYAQVAADNGFPEPSGAPHVTISSIVGLLTSVAEERIEFVYPDIFNDPERDTFHYGTFPEGFVWSSATSSYQIEGAWNVSDKGVGIWDTFTHEGGHVYNNDNGDVACDSYHKYEDDVALMKAMGLHYYRFSISWPRLMPDGTAASLSADGVRYYNALIDELVANDISPMVTLYHWDLPQALQDQGGWGNETIVDRFNDYARACFQNFGDRVKLWITFNEPWIVSLLGHGSGAFAPGIAEPAILVYTVTHHLILSHAHAYHTYRTEFKDTQNGQVGITLNTDFIEPADRSKPADIEAADTTLQFNFGWFAHPIYIDGDYPDIMKTNIARKSAYQGFNQSRLPEFTADQKAFVKGTGDFIGLNHYTTTYATNATPDENDRLPSQASYWNDQNIWSWKDSNWPPSGSSWLQIVPWGIRRLLKWISDEYGSDLPIYVTENGVSTKDVFELEDTIRVDYYKSYINEVLKGLTITLISYCILLVVICVSNDETRFVYPDVFNDSQRDTFLYGTFPEGFVWSTATSSYQIEGAWNVSDKGPSVWDTFTHEGGNVYNDDTGDIACDSYHKFTDDVALMKAMGLHYYRFSISWPRLMPDGTAASLSEDGLRYYNALIDELVANDISPMVTLYHWDLPQALQDQGGWVNETIVYRFNDYARACFQNFGDRVSLWITFNEPWIFTLLGYGTTTFAPGNVVDPAVKIYTVGRNVILAHATAYNTFQREFAATQTAKIGITLNSDFFEPADRARQSDLDAADRALRFNLGWFANPIFKNGDYPQIMKASIDTKSATQGFAQSRLPPFTDEEKEFIRGTADFFGLNQYTTVYATPDTVNDSLPSQANYLNDRSVYIYRDPAWPGAGSAWLKIVPWGIRRLLNWIAEEYGKELPIYITENGVSTHDVYQLDDKIRVDYYKAYINEVLKAIELDKVNVKGYTAWSLMDNFEWASGYSERFGMHYVDFNDPERPRTQKASARFYAQVVADNGFPEPSGAPATVSFSLAGLVTCVLFALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGA5</accession>
    <name>A0A8B7YGA5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dynein axonemal heavy chain 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Axonemal beta dynein heavy chain 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ciliary dynein heavy chain 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 26 27 28" type="primary">LOC110980179</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26 27" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">As part of the axonemal inner dynein arm complex plays a central role in ciliary beat. Expressed in sperm flagellum, it is required for sperm motility. Dyneins are microtubule-based molecular motors possessing ATPase activities that can convert the chemical energy of ATP into relative sliding between adjacent microtubule doublets to generate ciliary bending.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Part of the axonemal inner dynein arm complex that consists of at least two heavy chains and a number of intermediate and light chains. Interacts with DNAI4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092272.1">
        <property type="nucleotide sequence ID" value="XM_022236580.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092273.1">
        <property type="nucleotide sequence ID" value="XM_022236581.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092274.1">
        <property type="nucleotide sequence ID" value="XM_022236582.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092275.1">
        <property type="nucleotide sequence ID" value="XM_022236583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980179"/>
    <dbReference type="KEGG" id="aplc:110980179"/>
    <dbReference type="OMA" id="ILKNDMQ"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
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    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="23">
        <location>
            <begin position="1891"/>
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            <begin position="2503"/>
            <end position="2650"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
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            <begin position="1"/>
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        <location>
            <begin position="1594"/>
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    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="3111"/>
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    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="3317"/>
            <end position="3400"/>
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    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="3631"/>
            <end position="3658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004611"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00071813"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00078558"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00082099"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022092272.1"/>
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        <source>
            <dbReference type="RefSeq" id="XP_022092273.1"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_022092274.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022092275.1"/>
        </source>
    </evidence>
    <sequence length="4523" mass="518194" checksum="B20CD5FD64186AD2" modified="2022-01-19" version="1">[encoded data, 4523 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHU7</accession>
    <name>A0A8B7YHU7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylyl cyclase-associated protein 2-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">LOC110979574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:actin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:adenylate cyclase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cAMP-mediated signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028417">
        <property type="entry name" value="CAP_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01089">
        <property type="entry name" value="CAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091196.1"/>
        </source>
    </evidence>
    <sequence length="102" mass="11098" checksum="BECD76841C89A742" modified="2022-01-19" version="1">GCKKTALVFDQCLGSVDTVNCQSVQMQVMEKVPTVSIDKTDGAMLYLGPDSLDTMIITAKSSEMNVLIPKADGDYTEFALPEQFKTTYNGKTFVTECQDSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJR2</accession>
    <name>A0A8B7YJR2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110979926</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022091806.1">
        <property type="nucleotide sequence ID" value="XM_022236114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJR2"/>
    <dbReference type="GeneID" id="110979926"/>
    <dbReference type="KEGG" id="aplc:110979926"/>
    <dbReference type="OMA" id="RDACECD"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF100">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034544878" description="Phospholipase A2" evidence="9">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="10">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="67"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="74"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="83"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022091806.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17693" checksum="C76BC3DF938D6798" modified="2022-01-19" version="1">MKIFLLLVAVTLVSGKQIGTSNILQFNSMNACSVGISYSQAISDYLGYGCYCGFGGSGTPVDETDKCCETHDNCYKAATSNGCSMIDRYTIEYDYQTITGSDGKCQITCKAQADYDANDQDAQCKAFMCNCDREGAECFAKKRPTFNPKYIGWSNLFCWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKW2</accession>
    <name>A0A8B7YKW2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein-signaling modulator 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110981044</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GPSM family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093903.1">
        <property type="nucleotide sequence ID" value="XM_022238211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKW2"/>
    <dbReference type="GeneID" id="110981044"/>
    <dbReference type="KEGG" id="aplc:110981044"/>
    <dbReference type="OMA" id="REENDNC"/>
    <dbReference type="OrthoDB" id="286233at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000043">
        <property type="entry name" value="G-protein-signaling modulator 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003109">
        <property type="entry name" value="GoLoco_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052386">
        <property type="entry name" value="GPSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45954:SF1">
        <property type="entry name" value="LD33695P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02188">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00390">
        <property type="entry name" value="GoLoco"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50877">
        <property type="entry name" value="GOLOCO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022093903.1"/>
        </source>
    </evidence>
    <sequence length="630" mass="70249" checksum="1B7478C7652625AF" modified="2022-01-19" version="1">MMDASCMELALEGERLCKAGNCKAGVQYFEAAVEVGTDDLRTLSAIYSQLGNAYFYLQDYTRALEYHRHDLTLACTLGDHIGEAKASGNLGNTLKVLGKFDEAIVCCQRHLDISRELGDRVGEGRALYNLGNVYHAKGKHAGRAGHQDPGDFPEEVIACLKKAVEYYELNLAIVKSLGDKAAQGRACGNLGNTHYLLGNFETAIGFHKERLSIAKEFGDKAAERRAYSNLGNACVFMGDFETAADYYKKTLHIARRLGDIAIEAQACYSLGNTFTLLRDYETAVDYHERHHRIAQKLKDRVGEGRACWSLGNAHTALQNHQKALHYATLHLQISREVGDKTGELTAQMNLADLRAVLGLDKDPCGQDGLLQNADKKTLKEKEVNMQRRQSMERLELVTMTPDKNAAGATANGKTKLPAGAKFKRKGSNKEKLSRKSSNTSSTSSSSGDSAACLRTENVNIQVSPQQRSSPEIMDDDDSFFDVLSRFQGKRMDEQRCSFNRMQDKQRERDSGEDRDYPMKEELMNQIASFQRSRLNEQRSSICNLPGLKTNNEEVLGQLLQKGSQGVPDDDFFDMLMRCQGSRINDQRSEPPVLQPAPTVPDEDFFALIQRIQSKRMDAQRADKGPQDQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLS9</accession>
    <name>A0A8B7YLS9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110981180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110981180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094218.1">
        <property type="nucleotide sequence ID" value="XM_022238526.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094219.1">
        <property type="nucleotide sequence ID" value="XM_022238527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLS9"/>
    <dbReference type="GeneID" id="110981180"/>
    <dbReference type="KEGG" id="aplc:110981180"/>
    <dbReference type="OMA" id="PVRICSH"/>
    <dbReference type="OrthoDB" id="10391789at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665592" evidence="2">
        <location>
            <begin position="19"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022094219.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15351" checksum="A4ABD826B84F9A99" modified="2022-01-19" version="1">MRIPAIAFLLLTLAIGHAVSLKCFQCYWLSDQGRGEFGPRACRDPFNSNSTRVREETCRQNNQCRKEYATTPGSDVIEEVSRGCTPFCEEKCQDGTVLEKPVRICSHCCSDNFCNRAGAVTFGPVTMIASAITAAVASVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN01</accession>
    <name>A0A8B7YN01_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110981403</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094639.1">
        <property type="nucleotide sequence ID" value="XM_022238947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN01"/>
    <dbReference type="GeneID" id="110981403"/>
    <dbReference type="KEGG" id="aplc:110981403"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022094639.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17155" checksum="7135AEACEF69B309" modified="2022-01-19" version="1">MGHLLTEVCYKYGVYLSPLTAALITTKHLEFNKSSVILKEDVNNNNKRSEPDTSEQRSDERSECYSGQDEPRSRVQVGQVSTCNKGKSLFVCERLLVQVGASHELFTAGVKCSRSVKWKSPALVTSCLQEKWRQKLVSSQRHKLQGHRVSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN04</accession>
    <name>A0A8B7YN04_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HTATIP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110981112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Monomer. Forms homodimers during oxidative stress. Interacts (via N-terminus) with elongation factor EEF1A1 (via middle-region); the interaction is direct and competes with EEF1A1 binding to guanyl-nucleotide exchange factor EEF1B2, thereby inhibiting GDP for GTP exchange and reactivation of EEF1A1. Interacts with nuclear transport receptors XPO4, IPO5/RANBP5, IPO7, IPO9 and KPNB1 as well as GCN1L1/GCN1 and LRPPRC probably through their HEAT repeats. Binds NCOA5/CIA.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094042.1">
        <property type="nucleotide sequence ID" value="XM_022238350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN04"/>
    <dbReference type="GeneID" id="110981112"/>
    <dbReference type="KEGG" id="aplc:110981112"/>
    <dbReference type="CTD" id="10553"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05250">
        <property type="entry name" value="CC3_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000271">
        <property type="entry name" value="oxidoreductase HTATIP2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="8">
        <location>
            <begin position="62"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00093483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022094042.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34551" checksum="75F694099B4DFFE6" modified="2022-01-19" version="1">MWACRIFSSLAVIFLVISLIIGYIAQIPIENEEIINRMASNIDEKMDAFREKNQTAFVVGYTGEVGKEVVKELARTKIFSNVFLIGRREVKYEDELFKDFKMEQKIVDFDKLDDFANVFKGHSVGICALGTTKGKAGKEGFIKVDHDYTMKVAELAKAGGCKHYNLISSLGANKNSFFLYTKVKGQVEEETRELGFERATVYRPAVLMCDRQESRTGEWFIKKVLAPMEYLSPGSMTSPTTTVAKAVVNTIISPVTQAFEIIEAKAIHRLTKPQAAKACKMQAATDDQATGVTDTQTPVATDTKAQEAAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN43</accession>
    <name>A0A8B7YN43_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Speedy protein A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981026</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Speedy/Ringo family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093870.1">
        <property type="nucleotide sequence ID" value="XM_022238178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN43"/>
    <dbReference type="GeneID" id="110981026"/>
    <dbReference type="KEGG" id="aplc:110981026"/>
    <dbReference type="CTD" id="245711"/>
    <dbReference type="OrthoDB" id="9442170at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020984">
        <property type="entry name" value="Speedy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052316">
        <property type="entry name" value="Speedy-Ringo_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31545">
        <property type="entry name" value="SEEDY PROTEIN A/C FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31545:SF5">
        <property type="entry name" value="SPEEDY PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11357">
        <property type="entry name" value="Spy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093870.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43118" checksum="20873E00D221D563" modified="2022-01-19" version="1">MTYSLHDIDPSAAVTHSRRPRPKCSSHGRDVKFFSKAMGKGSLQKDFEFPSVILSCFQCSSVATPVLTDKLQVRGEGMRVDVMKNVPGVTVVQPIKRRIGAETAAPRGPCRDITNVTASLCSPPKRVKNAPMTVTSKEMAAFLKIFDDSLIRDFLWMDSCAKVADKYLIAMAFAYFKRANYTTNQYTRMNFFVALYLANDMEEDEEECKYEIFPWALGLTWRDKYPSFLRKRDKLLKTIEYRAAVSRKCCEELMAISPEHSIWMRERQLHHSGAIRHYENYVGSDDSNENYPRGPGMSPVHCELCAESGSFAYCSPGSQFTTSPSCHLYLASCTDTSTDSLGEETPPKPYSPSMFDMHGLKSTLQTEPNEEDSYFWASCHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNI5</accession>
    <name>A0A8B7YNI5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WASH complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Coiled-coil domain-containing protein 53</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110981093</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC53 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094010.1">
        <property type="nucleotide sequence ID" value="XM_022238318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNI5"/>
    <dbReference type="GeneID" id="110981093"/>
    <dbReference type="KEGG" id="aplc:110981093"/>
    <dbReference type="OMA" id="GCETKFV"/>
    <dbReference type="OrthoDB" id="268027at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000025">
        <property type="entry name" value="Putative WASH complex subunit CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019309">
        <property type="entry name" value="WASHC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015">
        <property type="entry name" value="PROTEIN AD-016-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13015:SF0">
        <property type="entry name" value="WASH COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10152">
        <property type="entry name" value="CCDC53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022094010.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="21151" checksum="EF2C681A0ADE6CCE" modified="2022-01-19" version="1">MDADGLPLVGPGVDLTKVGAIHPKRLLAFLNHFVTHTTRFLNKFSCVCEQKLSDLNTRIQRLEVTMNILEAKLASIPGLEGVSVEATPAPGPTPEPEPAAAANLPALPPSEEQNLPAVEPAPEAPPTMTVSQDPRYMKYFKMINMGVPVGALRQKLTLEGLNPDLLDTPNAPAPPAAQDDSDSTFSESSEEQEEFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YP47</accession>
    <name>A0A8B7YP47_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase B-like</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110980650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022093226.1">
        <property type="nucleotide sequence ID" value="XM_022237534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YP47"/>
    <dbReference type="GeneID" id="110980650"/>
    <dbReference type="KEGG" id="aplc:110980650"/>
    <dbReference type="OMA" id="YQEGYWA"/>
    <dbReference type="OrthoDB" id="443524at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF3">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034967441" description="Phospholipase B-like" evidence="7">
        <location>
            <begin position="24"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022093226.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="62909" checksum="F4FF54FC0CDD4C1A" modified="2022-01-19" version="1">MAVLGEALSHFVLISAVFYHVAARQPSSSRCVSVVLDHAANALKLVDGYHPNSSVAWGNFTEIQQQTGWNYLTVSTSPEYNDTFQAYAAGLVEGFLTADYIYMEWFNTQASFCHTMTPDCEKIKSFLGENLEWMKQQVELNPDDPYFYQMGLVLNQVDGVKDGYMNKPHRPTIDIDPFGFLLFQAGGDLDGIEAALKADGGRKRGRFSGHCSALIKLLPGNKDLYVSHVTWTEYGDMLRIVKKYNLPFRMSPQLSEIVPGREVTFSSYPGPIISGDDYYITGSGLVTMETTIGNENPDLWKFVKSKGTVLEWMRTVLANRLASSVTEWTDIFSKYNSGTYNNEWMVVDYKHFTPGQPLPTEGVFALLDQIPGQIESKDLTQLLSQQTYWPSYNIPYFPDIFKNGGFAEEAAKYGSFFIYDKAPRANIFRRDHHKVTDLASMIKLMRYNDFQHDPFSRCNCTPPYSGENGISARSDLNPPNGTYPFPALGFRCHGGTDMKVTSSDMYRSLSMVAVSGPTHDQQPVFQWSKSRCDKEQLHMGQPDLFNFDPVKVVWEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQF9</accession>
    <name>A0A8B7YQF9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane protein 87A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110980908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022093666.1">
        <property type="nucleotide sequence ID" value="XM_022237974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQF9"/>
    <dbReference type="GeneID" id="110980908"/>
    <dbReference type="KEGG" id="aplc:110980908"/>
    <dbReference type="OMA" id="TKAPNDD"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034120751" evidence="8">
        <location>
            <begin position="24"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="9">
        <location>
            <begin position="275"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022093666.1"/>
        </source>
    </evidence>
    <sequence length="602" mass="67917" checksum="04A58D5BF0EF044F" modified="2022-01-19" version="1">MDSCGRTCYFVLVLILFANWCSCDSPEQGIFSFPLDEANRFGGVSKNLQVETEIGITVECADAKEGKFTVEWMVRFTECNELRPELIVNSSTFIESLFSGNGAEQSMLTEEDYIAVEKSNMSNEMTCQGHTNLKDETDSNSFTCVTQYDQMPHCNFIGVRPPTEAAPTTAPAKGQPKQSAPTKDKDAKPAIKRRAAPPSTASVASKPVNATETPKSNTTTTSLLKDRVTKINERPGRYWVLVHVKSMESAKKDTKVTVTIKMKSPSGFLSAYQAPLLAFYGVMCGVYSILTFIWLVMMALQWRDLLRIQFWIGAVMLLGLLEKAVFYAEYENVNKTGISVPGGIIIAELLSCVKRSLARMLVIIVSLGYGITRPRLGRDLHWVLGAGMLYLILSSVESCLRVEGTEQHDMIAILPLAVLDAIICWWIFKSLVDTTRTLRLRRNMVKLWLYRHFTNTLIFCVVAAVIFLLWSTKTHRWTECMKKWNELWLDDAYWHVLFCIILIVIVILFRPTANNQRYAYSPLTDREADDESHEPMLNDAFEGMKMRNVVTNRNESQSSNKVEDDLKWVEDNIPASVADAALGAFDDSEEELVTNLERSKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQT5</accession>
    <name>A0A8B7YQT5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Very-long-chain 3-oxoacyl-CoA reductase-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110981629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095037.1">
        <property type="nucleotide sequence ID" value="XM_022239345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQT5"/>
    <dbReference type="GeneID" id="110981629"/>
    <dbReference type="KEGG" id="aplc:110981629"/>
    <dbReference type="OMA" id="SGHWNHE"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000137">
        <property type="entry name" value="Hydroxysteroid (17-beta) dehydrogenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095037.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="34905" checksum="5A95CD69E6276D71" modified="2022-01-19" version="1">MPELTPFGALNPALATLGAVVAFCATFRLVSSLVKALKSFFLAGPLGLSTNVQKYGEWAAVTGATDGIGKAYVEQLAAKGLNIVLLSRSPDKLNDVAAEVESRYKVKTKAVAVDFSGGAEIYSKIAKEILGLNVGVLVNNVGVSYPFPQYFHELPDQQKFLADMLNLNCLSVTMMISIVLPGMLERKKGIVINLSSASGMNPSPLLSVYSSSKAYVDFLTRSLQTEYGSRGIIFQSVLPFYVTTKLSKIRRSSMTVPTPTGFVRSALATLGLEDRTNGCLSHSLQGWFVEAVPTWLLDKIQMSMHLGIRKTALKRLEQKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSV1</accession>
    <name>A0A8B7YSV1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Plexin domain-containing protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17 18" type="primary">LOC110981990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095777.1">
        <property type="nucleotide sequence ID" value="XM_022240085.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095778.1">
        <property type="nucleotide sequence ID" value="XM_022240086.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095779.1">
        <property type="nucleotide sequence ID" value="XM_022240087.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095780.1">
        <property type="nucleotide sequence ID" value="XM_022240088.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095781.1">
        <property type="nucleotide sequence ID" value="XM_022240089.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095782.1">
        <property type="nucleotide sequence ID" value="XM_022240090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSV1"/>
    <dbReference type="GeneID" id="110981990"/>
    <dbReference type="KEGG" id="aplc:110981990"/>
    <dbReference type="OMA" id="PYPIANI"/>
    <dbReference type="OrthoDB" id="6285106at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031152">
        <property type="entry name" value="PLXDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055:SF12">
        <property type="entry name" value="LD40707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13055">
        <property type="entry name" value="TUMOR ENDOTHELIAL MARKER 7 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665615" evidence="10">
        <location>
            <begin position="32"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="438"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022095777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022095778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022095779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022095780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022095781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022095782.1"/>
        </source>
    </evidence>
    <sequence length="562" mass="62021" checksum="303B19D79197112B" modified="2022-01-19" version="1">MARREPLTVMPLTALWCLLWLVSTLLQQCCANVWTSKSPVYELEGITEEPLDYLVQIHADHHQRHRRELPTQQPETDANVTVIVEDNHRYYTSQCFRSDAGGSAFWVDLDDQRIRPLVEAPETLATGARNGKNVHLNFVFPFYGHEVSSLVITTGGFIYAGSYIHKHLAATQYIAPLMADFSPLESSPVTGVRYFDNGTALTVEWREQNLLGSIRAGIFTFQVTVVKDGRIIFAYKEIPIPVDSISDARHPVKVGIADAYYIDELIAPFTKKREIFEYHSIDIDTSKVSSGTAIVISPLPTCNLKTSCSSCVAGDVAFNCTWCQQLSKCSDGLDRHRQGWLQSGCHEPENYIDDVTKCPEYIPPTEAPSRRPTAPPANVKVKDTTTVQNAVATTKQKAMTGPTVGDCEGVECQHGGTCDQGLCKCPSKYQGARCQKYVENHCQGVACKNGGSCVEGLTTHFCDCPVGISGTYCEVVDGPATQSKPSSSAKLTVGAIISIILITLLVLGLFFWAVYAYRHPTSPSGLFILEAKHRIRGRGRGANGVKYKYHQHMEGNQIDFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSW2</accession>
    <name>A0A8B7YSW2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110981878</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022095560.1">
        <property type="nucleotide sequence ID" value="XM_022239868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSW2"/>
    <dbReference type="GeneID" id="110981878"/>
    <dbReference type="KEGG" id="aplc:110981878"/>
    <dbReference type="CTD" id="3978"/>
    <dbReference type="OMA" id="NDFTCEY"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="779"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="69"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1012"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="292"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1018"/>
            <end position="1039"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022095560.1"/>
        </source>
    </evidence>
    <sequence length="1052" mass="117406" checksum="FA3695E53B1567C8" modified="2022-01-19" version="1">MNGLLLIGGRRFLYEACKRRLFDRFEGLQSHPVFHCRQRNLIKTEANLLRRPSFHLTMAQRSIMSFFSPKRHMGTTDKVASSGNIQDDRSPLKVKNSTNQESPVEQTRKKFRRILDSDEEDSNENVSRTTPTKTAPVESPPMEDTPKRKAATADELASDPIPPSPVTPSQALETASPSSTPGSIPLRKTARKHMRKRKAEEQKGEEQDIATPIKAESESKKIKTDKLLTPETTSEEATKSTTEVDSPVTKVKEEMMDGVEEPPEAKEDMQDGKNGKAKPRDTKKEKKSPKAKNSETREKKAETKKAKTPPKKDSKREVLKPSIKNESKGAEESKASGNKTEKMTSPKVKEEVASPAGSKTSSVTEEERDKGEKPKDGKTPAKNVFGMFSKVAASDSVEYNPGAPRYHPVKDACWKQGERVPYLALAKTFDIIEATSGRLKTIETLTDFLTSVLVLSPKDMEMCVYLCLNKIAPAYEGIELGIGETILMKAIAQSTGRTVEKVKADAAQQGDLGLVAQSSRSNQRTMFTPARLTVLKVFNTLKEIATMSGNASMSRKIEKIKSLLVACRDCESKYIIRSLGGKLRIGLAEQSVLVAIGHAAVISPPGIAVDSVLSKSKVSDALKKKMDDAALIIKTTYCELPNYGAIIPALLEHGYENLPEHCKLTPGIPLKPMLAHPTKGVSEVLNRFQNMAFTCEYKYDGERAQIHLLGNRKIHIYSRNQENNTSKYPDIIKRLPSAYDPEKVKTCVLDAEAVAWDRENQQILPFQVLSTRKRKDAAEAEIKVQVCLFVFDLLFLNEESLVTKTLRKRRELLNSHFTPVEGEFMFAKSMVSTDTEDIASFLDESIKGNCEGLMVKTLDEDATYEIARRSHNWLKLKKDYLEGVGDTLDLVVIGGYHGRGKRAGTYGGFLLACYDDENEEFQTICKIGTGLKDEELDTHSKFFKAHVIDKPRPYYRHDTSHTPDHWFDAVQVWEVKAADLSVSPTHRAAIGIVDPEKGISLRFPRFLRVRDDKKPEEATNSSQVASLYNNQDQIKNQKATGVLKPKASEDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YV45</accession>
    <name>A0A8B7YV45_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lymphocyte expansion molecule-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110982798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097173.1">
        <property type="nucleotide sequence ID" value="XM_022241481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YV45"/>
    <dbReference type="GeneID" id="110982798"/>
    <dbReference type="KEGG" id="aplc:110982798"/>
    <dbReference type="OMA" id="SSQMIMG"/>
    <dbReference type="OrthoDB" id="6275292at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033557">
        <property type="entry name" value="CIMAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34914">
        <property type="entry name" value="LYMPHOCYTE EXPANSION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34914:SF1">
        <property type="entry name" value="LYMPHOCYTE EXPANSION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022097173.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46786" checksum="DB133EB11A52B3E9" modified="2022-01-19" version="1">MAAVKAFQGAPFGTQKSRFDVSGVHPQSKMPGTFTEVWYDNKSMTGLRRKRGPGTYKVEVGTFSQNAVENRASGPGWARAYETARMAALPHLLHKDQWEKKKMLVKNLGPGTYNIKDFLHLMDDRPRSTRGICQTRESRFRGTATSEVPGPGTYGEGGIPHTAVEKKAQVSASTVGLLDAGSSTPRHLPSVGCELGPGTYETESFTDKLAKKVTSLRGPYDLFTGDRNAVIKTGHLAKAGQHHLGPGQYSLKSFVHKWDDEHHQWQGRFGKHSQYPERPTERMHCSTLSQWPRCQSEPGPGHYTARELTRVEGKNLPPFISSAERFDKRARKFFTGQTNPVGAGRYDLQRYEDAQHRNGHRSVFNSKVKRERTSRDNMMQERIRAINLRPEDKSDLTVQKGEDYIKARRVIYTQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YV53</accession>
    <name>A0A8B7YV53_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110981705 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095206.1">
        <property type="nucleotide sequence ID" value="XM_022239514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YV53"/>
    <dbReference type="GeneID" id="110981705"/>
    <dbReference type="KEGG" id="aplc:110981705"/>
    <dbReference type="OMA" id="SYEIYWT"/>
    <dbReference type="OrthoDB" id="5972940at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032736">
        <property type="entry name" value="Hinderin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28375">
        <property type="entry name" value="PROTEIN HINDERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28375:SF1">
        <property type="entry name" value="PROTEIN HINDERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15369">
        <property type="entry name" value="KIAA1328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="743"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="488"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022095206.1"/>
        </source>
    </evidence>
    <sequence length="840" mass="95431" checksum="F41FAE334AD7FF35" modified="2022-01-19" version="1">MADGDGNPHEIFWTREERSYNKDSDGYLHSFVPGVDQPGNIKMTQKMKFHQSNDMLNKAMKASGDERLMKERTNTESRVENHDRRKDKDIHKSKTSSVEAPRLKDKPSLKDLKPEDKKRIANLIRELAKAGEEKEVIVQQLSVERRSYEDKVNKLHEQMAAIIQERELTQKQYLECQKLLAEYQSQLASEQEKLALSLHHRASPPKFGMAPQSPTKPAPDYAPVVKKNQSNTPHKERQLRTLRVTDHQTTSQHATLTQSNGYNNAPHTGYRYPVTHQSSLVQDYQVPDIHQTSSWNQPAGTHQHPVPRTQLSHPNIIGTEFNPLLASTHRSQQVHSGNTSWTEPQVRVLASRSEPAMYVSYGTNRNPQGYMFQPGLDPEHRIHLPQSGPSSSYPKDSQEMFGSRPQSGEFRPLQPELETDFESQDSKSPQYVAAFWNHQNGAPDGLQGNTQRDKIGSNNHHHGEISEIPHAVTRQPAYQATGLPEQCHAVLERQRHELRQEQALLRQKLKDQEKILLQKQNQLELHRLRQLEQEGQRHSTSSHMEREWLDHGSGTVATSHPQKNVKDLEWEEPNIYSGMQHEVPSGSENDSDEVISTNYPPESFMNQSTSKEALETSMRRLHVSPRSRNPCGTDMSNARVAIATENPSQRTRGIKIDGYASLYPNSQPRNKIHVQGSMPSYSPSTSSSGMSQARMVDRSTSPLYKDHKTETARSPGKGGLSLSPGKVHITPAPAAHTNREPIQMQHRRRRAVSLPQSPRYHSGITKEKKSNATRLSDLISEMESPTQPNTTHARLVNITDSRSMIRQRYISTPDLFQDVVDTDTDTELQESRILEDVFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW12</accession>
    <name>A0A8B7YW12_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Neuronal acetylcholine receptor subunit alpha-10-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110982521</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096675.1">
        <property type="nucleotide sequence ID" value="XM_022240983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW12"/>
    <dbReference type="GeneID" id="110982521"/>
    <dbReference type="KEGG" id="aplc:110982521"/>
    <dbReference type="OMA" id="LIQQQWI"/>
    <dbReference type="OrthoDB" id="10035934at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 15" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034395332" evidence="15">
        <location>
            <begin position="31"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="39"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="94"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="271"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022096675.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="60412" checksum="33D332500599AC32" modified="2022-01-19" version="1">MARTINCGWRFLMTATLPLICVIFLEPVCGNSLYSEGHQERLVSDLLREYSRYVRPVLNETKVLEVFYHMKLSRILKIDEVNQVLTTVVRLEQDERNQILTTAFWLEQRWRDDFLVWDPLDYDNITAINIPTRQIWIPDTVLYDSADVDKEPGTGIMMTNAVVSSEGGVFWAAPAIFKSSCSLDITYFPFDKQTCPMKFGPWAYKGNEVVMRTVAEKGDWSQMTTNGQWELLDMPVVAHLVEYGCCPDPFSDVTFTLKLRRKALFYVFSLLFPSIFMSLISFLSFYLPAESGEKIGLNITVLLSLVFFLLLGAQLLPPTSDTVSLLGQLLATIIVVMSLETAGSVVILRLHHHIPSRPPPRWARKLILDRLAYFLRIKGRRHAFHDYTSADGEELEGEKATAPHRCDDLFEYDQQNSLLNSQALGVSLLQQLQLEPGSYGAKDTGGPGGFMAEGAAEYGTDATEVSLGATVQRIGRYIDKLVNRCKRKEKISLVQQQWIDMCVILDRLLMLLFALAIVMTSLIIILKMTLNYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWW7</accession>
    <name>A0A8B7YWW7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Cell cycle checkpoint protein RAD17-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14" type="primary">LOC110982809</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097185.1">
        <property type="nucleotide sequence ID" value="XM_022241493.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097186.1">
        <property type="nucleotide sequence ID" value="XM_022241494.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097187.1">
        <property type="nucleotide sequence ID" value="XM_022241495.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097188.1">
        <property type="nucleotide sequence ID" value="XM_022241496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWW7"/>
    <dbReference type="GeneID" id="110982809"/>
    <dbReference type="KEGG" id="aplc:110982809"/>
    <dbReference type="CTD" id="5884"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001661">
        <property type="entry name" value="RAD17 checkpoint clamp loader component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="392"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022097186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022097187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022097188.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="73563" checksum="AB3154C8351DE891" modified="2022-01-19" version="1">MSSKTIPSSQRQQWVSPSFDDFEFDLSAGTSQQTKPAIKVSHGQNTLHQLLSRKRSRPEGGSERVRTADRQKQRKATEADTWVDKHTPQIQSELAVHKKKIVEVEEWLRRHVKEKRPGRQTKAPILLLTGPAGAGKTATIHVLAKQLQMEVQEWSNPNTMTYDPDRAVQDRQDFKSIGGPISQSQTALFQDFLTRANRYPTLELSGGQALRQKLCLVEDIPNAFHRDPQTFHNILRKFTSTGRSPLVFIISDSYGGESSAFKLFPKDVQGSLGVDNISFNPVALTNMVKVMTRIATTESSQGKRRFAVPSKATIEALAIASAGDIRSAINSLQFACLKDTHDLDRALVRNSSKSSKTKPSSKQTGGKTGRQTGEKTSSEDTALAAIGGRDTSMFLFKALGKILYCKREPKMPEDPTLPAHLAHHDRDRLKIHPEDVLEHTHMSSENFNLYLHQNYLDFYEQLEDVVEASRYFSDSDLLTCEWRSRSSMTTYGASLTSRGVIHCNTARSRCNSAGGGGWKPLHKPQWFEINRKYNESCAGAKGLFVGHCWTPVELQTQLLPYLALISVPLENPGQINFLQEITRFTGNRFTRRRRPERLDEKDAVNEDEDDDIISSQGDKLLPQRRPHINPEHADPLMTKTKTEAAEIIIEDFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWZ3</accession>
    <name>A0A8B7YWZ3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SREBP regulating gene protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110982003</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SPRING family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095806.1">
        <property type="nucleotide sequence ID" value="XM_022240114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWZ3"/>
    <dbReference type="GeneID" id="110982003"/>
    <dbReference type="KEGG" id="aplc:110982003"/>
    <dbReference type="CTD" id="79794"/>
    <dbReference type="OMA" id="CNTTSHC"/>
    <dbReference type="OrthoDB" id="70142at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000640">
        <property type="term" value="P:positive regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019352">
        <property type="entry name" value="SPRING1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13481">
        <property type="entry name" value="SREBP REGULATING GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13481:SF0">
        <property type="entry name" value="SREBP REGULATING GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10218">
        <property type="entry name" value="SPRING1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022095806.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22672" checksum="1ACC8148DC21ED2A" modified="2022-01-19" version="1">MFPAKILRKRWVLAVIFIFSLFYFLNSTFNQEVPIGVISDRFGDLPHTTLQLQLRAGGEAIDQNNSSNCQNSQQGHSLVVDNRGFVCPREAVQTNSCCDPEHRLSLRYTCEGCRSSTNCCSVYENCVSCCMHPEKEDVVQGVLGKASNTFKLLFREVNSQYEFCLTKCRTSSESVQHENTYRDPVAKHCFGESPPDLKPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY97</accession>
    <name>A0A8B7YY97_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">A-kinase anchor protein 1, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC110982240</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096223.1">
        <property type="nucleotide sequence ID" value="XM_022240531.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096224.1">
        <property type="nucleotide sequence ID" value="XM_022240532.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096226.1">
        <property type="nucleotide sequence ID" value="XM_022240534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY97"/>
    <dbReference type="GeneID" id="110982240"/>
    <dbReference type="KEGG" id="aplc:110982240"/>
    <dbReference type="OMA" id="FMNNCYS"/>
    <dbReference type="OrthoDB" id="10069557at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22395">
        <property type="entry name" value="KH-I_AKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20407">
        <property type="entry name" value="Tudor_AKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047368">
        <property type="entry name" value="KH-I_AKAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047367">
        <property type="entry name" value="Tudor_AKAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF65">
        <property type="entry name" value="A-KINASE ANCHORING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="4">
        <location>
            <begin position="409"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022096223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022096224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022096226.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="63282" checksum="E4FA95D36A003367" modified="2022-01-19" version="1">MAQLRYTKYVAVCGTALTAGLVGLYLYKRRAAKKEEERRAKGEQESKAEENMDSNESKPESQSERDTARDIDQQVTVPDDSGIDVEEVVMLREKSLDQEFPQTGDKQLAVVDEVQDMFEPLDTIESAPTESSCKEEVMLVEEPVMQSAQMPVESLLPPSSSTLESSPRGYSEAGSEGSLTLDWATAVDQVDEMHKEESLVSPTTSLQSHPEGSVAGSDLSTETNSDSSSLDSGRCTGSTTSTGTLQHPQPAVREMPTVYQFEFPAKECGRLIGKAGKNIKGIRSRSGAKVTLRDWPDEKTKQICVIEGFQSEIDAALADIQNKFPLVDTSKQYIEMEQVTVPAATVPEMSQIHLHEEIVNDVIVSSVVSAGHVFVQQPTHPTYMALTRLNTFMNNCYSQMDMTPPLPRPIEVGVICAAPMMQGWYRAQIVDIFPDTDEVDLKFLDFGGYARIESYVLKQIRTDFMSLPFQANECYLSNIAPLAGEEDFSEVARLFVEQVAQNFNILQAQVTGYCEDGMPFIELFYTDSERKVQSLNKELVNQGLVTWYEEGMEESLTDTSLLSEVEPTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ73</accession>
    <name>A0A8B7YZ73_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Proton-coupled folate transporter-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11 12" type="primary">LOC110983221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022097987.1">
        <property type="nucleotide sequence ID" value="XM_022242295.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022242296.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022242297.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097991.1">
        <property type="nucleotide sequence ID" value="XM_022242299.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097992.1">
        <property type="nucleotide sequence ID" value="XM_022242300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZ73"/>
    <dbReference type="GeneID" id="110983221"/>
    <dbReference type="KEGG" id="aplc:110983221"/>
    <dbReference type="OMA" id="RANDTAC"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="14"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022097987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022097988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022097989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022097992.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="53821" checksum="8119F85E8CA99671" modified="2022-01-19" version="1">MTFWYLNLVTVEPVLFLFTMSLFMQYPVTQLLVLHKVCLSIHNSTAVCANISEDADEENEVQSTAAHWNLYLTIAINLPGALMSVIYGAISDQVGRRGVMVLPSVGLILGSVGFFLQSHFIHAHVAYLLPSALIIGVFGNVGASYIALMSHICDITEVSSRTKRLGIMESMSFIGGPIGMMAAGAMVQHHGFEVVYLLIIALNSVIVLYIALRLEEPSKRSVKSDKKLRSISHVWLRRMCRHVSSSLLRTLRVYFIKREDKRRRYLLIIQLIGILGIVAFAGELDLFILYTKHSPLTWSASTIGIYLSVRTLLKGVPLAIGLPILFGYFRHRSVRFDLVLAMLGLVSVAASMILVAFSHSMFMMALVAGIGCLSGYPGAIMGSIKSKLVQPDEFGALFACTVLIQTAFVAAGSLLFNTLYSATLRVWPGLSFIGIGAIYMVNLVLVIYLWLDMADVKLNENHTPAEDREFAVKLLSETEDSEMDDAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1D7</accession>
    <name>A0A8B7Z1D7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/arginine repetitive matrix protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099414.1">
        <property type="nucleotide sequence ID" value="XM_022243722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1D7"/>
    <dbReference type="GeneID" id="110983971"/>
    <dbReference type="KEGG" id="aplc:110983971"/>
    <dbReference type="OMA" id="RYSMPLN"/>
    <dbReference type="OrthoDB" id="10450603at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022099414.1"/>
        </source>
    </evidence>
    <sequence length="745" mass="81653" checksum="61333A208E77FD61" modified="2022-01-19" version="1">MSDEATKDSQCTCVSKIIKLDPNLLQRRESLFASSEAQSIIEQMTGVSCNGQVILKKTTESQAEDPTEEAPAVETSSTEGKEDNKRVAMTNKSKAGKEREKHTMADVASKVMNSKLYTNDRTTRAVKKWRAFRTREERRLAGEDGQEKHEAKDDKDEKTDEAQSKVGIGDSSPSTASSITTTSAGANTTNTKFSLSRQDENDSNDDIDSDSESDSSDDSETKPTDQPRVATPTPPKSPVLHRPARARFGRRYSMPLNVMTPAPPRLSPAVSPPHGSPKASQESSPNRRPHVTAAITKLQNNREKLSMLFDKRSEVISSLDAESEVVGIGKRVTRLCNRRASDSMSTLSDFLRKQQISLTGSSTGRLLQRRGSVGTNILARNTRTPAVDSSQISPVAPGPNDDNKIRSGRPEFKSRSCEDVAIPNPPGQLHPPPPFHGGRRGSVCVGQIARVRDGTSPELQSPRRPPADGETPLGLICSSKKNVPQERNPDGDSGKDKDTANHKSPPQGPPQRYMKNRRGSVSLAHIAHAREMLQCKTLGNSESQKNGLSKSVPLTLANIEVHNTLLSPFSFQFFSDRIPTTAGAGPVKSEDSPKPAEVSTKPAANQAQGGVHVREGEPKLEGPETAREMGTSSLRQGSSPRRASTPAVPVSERKYSLFLRTDSEIREDIENEIQERVARRRRELMAVRCVSAKGAQRLEARALAQSAAGRLKRNLHEVTKQRKTKELMQIEEERNRLLKQMMLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1I3</accession>
    <name>A0A8B7Z1I3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Crk-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099463.1">
        <property type="nucleotide sequence ID" value="XM_022243771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1I3"/>
    <dbReference type="GeneID" id="110984006"/>
    <dbReference type="KEGG" id="aplc:110984006"/>
    <dbReference type="OMA" id="VRDNETS"/>
    <dbReference type="OrthoDB" id="5914531at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="3">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022099463.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12635" checksum="F125FBC23305854F" modified="2022-01-19" version="1">MSGIKEIPPWYFGKVTKGVAHERLSGTMSGTFLVRDNETSRGSYVVSVNENGMVVDYDIRKTGRTLKINDRDFADLAALIGYFQKYPLDTITLDIPCSKEGMESPPISPSWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2Q3</accession>
    <name>A0A8B7Z2Q3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Aladin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110984233</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099898.1">
        <property type="nucleotide sequence ID" value="XM_022244206.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099899.1">
        <property type="nucleotide sequence ID" value="XM_022244207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2Q3"/>
    <dbReference type="GeneID" id="110984233"/>
    <dbReference type="KEGG" id="aplc:110984233"/>
    <dbReference type="CTD" id="8086"/>
    <dbReference type="OrthoDB" id="411991at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045139">
        <property type="entry name" value="Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057403">
        <property type="entry name" value="Beta-prop_Aladin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494:SF0">
        <property type="entry name" value="ALADIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14494">
        <property type="entry name" value="ALADIN/ADRACALIN/AAAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25460">
        <property type="entry name" value="Beta-prop_Aladin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aladin seven-bladed propeller" evidence="1">
        <location>
            <begin position="181"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022099898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099899.1"/>
        </source>
    </evidence>
    <sequence length="555" mass="61532" checksum="FB77F6E5C3C921CE" modified="2022-01-19" version="1">MYYAQLLTVIERVLYMLLIFCGVDSKMLRNFTVLMRCKMDETTHTLTDVSDSPPPREGFMVLRELHEDLLTAQFKDADLSKQIAQGLTLPRVTLGVETLSSLATDEDAPSAFLPCDAHLPLWKKAWYLYKENGTCGLLNELTKRNTEAPSVMSTVACGCLAAIRWSSSLRGSFYPHMVLPNEKIVSQFSQTCSWEESAIRALAWHPHTNKCAVAWNDDVVRIFTANSDLVPTLKHRVQRCVACITWKPLSASDLAVACLACILIWHIDPSSLSIRPSASCAQILSQSGHGPITSLAWDPRGRILVSASPCDTAMRVWDVARETCVALRRNGGGGVSLLRWSADNTKLFAATPSKMFRVWETKTWSCEKWLDLLGHCQAACWSPDSNMLLFCTENKPIIYALGFKDIGVSRGAKTAVQCADMSKVMLQCRTEETSVGGLIQDMAWDPTGERLAVLFKPHDKDTDNLIVLFSTRLEPVLELIPSGFVRGEPGQIPELIAFKPNFRQGALLTVCWQSGEVSYIPLMFMPTQAIKDTANSTFKIPGANAPLSKELFSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4J2</accession>
    <name>A0A8B7Z4J2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Titin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099882.1">
        <property type="nucleotide sequence ID" value="XM_022244190.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110984229"/>
    <dbReference type="KEGG" id="aplc:110984229"/>
    <dbReference type="OMA" id="VMEPDEE"/>
    <dbReference type="OrthoDB" id="10072653at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007342">
        <property type="term" value="P:fusion of sperm to egg plasma membrane involved in single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000775">
        <property type="entry name" value="Bindin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02084">
        <property type="entry name" value="Bindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00761">
        <property type="entry name" value="BINDIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034725135" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1219"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099882.1"/>
        </source>
    </evidence>
    <sequence length="1571" mass="175083" checksum="870211D9F9EA9533" modified="2022-01-19" version="1">MDWQAQLVLTLTVFVILSLSCQAEDTACPPGCRCGVGQAACRKPYNGTQPLPNHTTKLELHTVDPIVLRALVQSVPQLKHLMLNRPEGFTSENDSTAQPDYEQRMMTVEELHDLQKGVIGLASLETLVMNEKALECSCDLLSLAEAAYGNGVDLYHVIKLLMSQSCRQEGLDLDLHSPLELLLLCSSRSSYQLKPFQSKPALLQPKESQLLSAEEKVSEIPGPSSHIRVRRAGEKKPKRGRRKKGKGKRRNRGKTWKGGQRRKGRKRTKGRKKGGEKPTNILTKEKSVNPGTRDVRLKVERNERESQPKEIEIKPVKPGRGKPRRGGKGQRKIKRRRKWRGKRKGKGRKRSKGRKRGRGRKRVKGRRRVKRRSRGKGKQPVIAMEDKEREREEEPATEETGVAGDKREPVEKIGTGNKIKKKNKKAMKELDQAEMPTKIPGSENSRKGKTKTPKKWKGKTKGIGKKKGTPPVIATEKEEAGTEEKPVNPEAVLEEAEAEPDAKETMPEELEIQPVEQEPVKPREKKPGRGGKGKKKRKGRKKGIRRQKGKGKRPFIVMEEEEAGTEEKLVNPETIEPMEEPVEMETKPEETEIEVVEQEPVIPGGKKLAKRRKGKKKGQGRKRGKGKKGGRKPPAVVIEEGEKEIEETAVNAETGEEGPMAEPVEMETKPEETEIELVEQEPGGEKPKKGRKGKKKGQGRKRGKGKKGGRKPPAVVIEEGEKEIEETAVNAETGVEGPMEEPVEMETKPEELEIELVEQELGGKKPAKGRKGKKKGQGRKRGKGKKGGRKPPAVVIEEGEPETEETAVNAEKGEVGPMEEPVETEMKPEEMETELVEQEQGGEKPTKGRKGKKKGQGRKRGKGKKGGRKPPAVVIEEGEKETEETAVNAETGEEGPMAEPVEMETKPEETELELVEQEPVIQGGKKPAKRGKGKKKGQGRKRGKGKKEGRKPPAVVIEEGEKETEETAVNAEKGEEGPMEEPVEMETKPEETELELVEQEPVIQGGKKPAKRGKGKKKGQGRKRGKGKKGGRKPPAVVIEEEEPETEETAVNAEKGEVGPMEEPVETEMKPEETETELVEQEPLIPGGEKPAKRGKGKKNRKGRKRGKGKKGGRKPPAVVIEEGEKEIEETAVNAETGEEGPMEEPVEMETKPEETELELVEQEPVIPGGEKPAKRGKGKKKRKGRKRGKGKKGGRKPPAVVIEEGEPETEETAVNAETGEEGPMEEPVEMETKPEETEIELVEQEPVTPGGKKPSKRRKGKKKGNRRKMRKGRKKGGQKQRAIVVNEEEPVKQEKPGAAEIGVIGAKVEPMEIQETKLAEAMRELDQTEIPFETEPLEPEMKLEEAETEPLWPETDLVEAETEPFEPDTEIFEAETELLEPETELVEAETELLEPETELLEAETELFEPETELVEEAEPLEPETELAEEAEPLEPETELVEAETEPLEPETELVEAETEPLEPETELVEAETEPLEPETERMEVNIESEEELFEPKTEVAEIDEKLMKELRDLLEATKMDLPVDINDPYDLGLLLRHLRHHSTLLAHIGDPDVKKEVLSAMNEKDETEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6M2</accession>
    <name>A0A8B7Z6M2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mediator of RNA polymerase II transcription subunit 17-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110984940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101289.1">
        <property type="nucleotide sequence ID" value="XM_022245597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6M2"/>
    <dbReference type="GeneID" id="110984940"/>
    <dbReference type="KEGG" id="aplc:110984940"/>
    <dbReference type="CTD" id="9440"/>
    <dbReference type="OrthoDB" id="10058398at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019313">
        <property type="entry name" value="Mediator_Med17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13114:SF7">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022101289.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="71860" checksum="56187893AE50547C" modified="2022-01-19" version="1">MDPVTVSIESLQEFQVQEVSLDGQETYTKPLSMSENLAKLAHKIDFTKPEGEEVESTLADEEKDAKKAEIKEESATVQAVQWPWESVHSKLRLALTEISVLSDILHISRWAKDPRYMVLDPVSQEQTQSKQIIQLLDKKKSLAAAASVLQNGAKRMMRQPPAGTTSSPQKPQHPNDFHADLLRLRQHWRLKKVGANILGDLSFRTAGSRFWHSGTFEVTKTTDMDSEAAEKKNQTPLKVTIPSDIEGTSHIQVLIQEGEADIATAFLPQPSRSRVSPDAHWQERLEAAQTVLFCKEVFAQIAREAVQLKSPVPHIVVGNQIFCTLFPGVQLCLTLCHNTSTDSQLSHGFCYEPSLTEPVKQPNHSHALEHSLHQLLRELHRSNMGGATPRPITSALTVSKKRRLAGPQAISRKELTDSQQGECLLEKVLKQAKHIVLRKRVADVITQLSCDLQDPIILVHWSAHSQPLVCTAKVHISTSGYEQIATTLLQLTVEVDQIRVLCKDGRVIHANHEEQQLKDLIQCQISQHQISSMLSLSKSMSMHILHYNFQLGVGSASKLGNASSVLVSTHHGQRMVAVRSDPLNGITVLVKGCKNPHDTEHKSNVVTDPKWETIMTDYREVDLERIPGRSFVNKMELLMAVLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8F8</accession>
    <name>A0A8B7Z8F8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110984918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101247.1">
        <property type="nucleotide sequence ID" value="XM_022245555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8F8"/>
    <dbReference type="GeneID" id="110984918"/>
    <dbReference type="KEGG" id="aplc:110984918"/>
    <dbReference type="OMA" id="IPLAMTY"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF142">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="481"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="698"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="699"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022101247.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="77937" checksum="D9B58C65AD758250" modified="2022-01-19" version="1">MSETSMMHELGNSDQGAVLAVDTGNEREGCGCGPCRPRCLVPLARPSVFSALMALVLVVELAAMNGYIGAITSTLEKEFLLSSSEVGAISIINDLVSLLVVGIFTYFGHSAHRPRVIGTGAVLVGVGTATCALPHFIAGPFSASLALNASEHQLCWESPNTTQPTHTPINRSKYSSLYLFIIGQIIVGVGNAPIIPLAMTYVDDAVEKYKTTAYVAVIYIGTSVGPMMGFLVSSWALSFYVGLGSIPWEQWPAVPPNDPRWIGAWWLGLLVLGVAMVVLALPLFFFPRTLNAPRKTTRKLEVEGLSCNGVELRGVSEAGWSKKGLPVDNLQLEKKVSETEMSLDHHKIKELTSKGSVKTIMGQTKDFMSALLRLGRNLTLVALTLGLSTELAIVSGLSTFGAKFIETQFGVGAGRAAFLTGVAIMPASCAGHLLAGALLRRFRLTAFQCSVFLCVTVLVTLCVYPALIFLGCETPTVVSDSSTMLSCSSRQCVCDDTVIDPVCGVDGLTYLSPCLAGCSRMDRENKTFSDCACIQRVGGNFDIGSTNISSDDEPEGWEAKVSACPAVCTMMIAYIVASSMSLFFMFMGQNPSMIINLRCVEKKDRSFAIGMLTCVIKVIGFFPAPVFFGVVIKSACLLYSSGEGAVEYKDTGSSVCWHYDLPVYRRRFVGLMIGLKSCSLIFFLIVMISLWRKRKEGEQCSEETNEETDERRHSASSEMSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9F9</accession>
    <name>A0A8B7Z9F9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-binding oligomerization domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110985530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102303.1">
        <property type="nucleotide sequence ID" value="XM_022246611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9F9"/>
    <dbReference type="GeneID" id="110985530"/>
    <dbReference type="KEGG" id="aplc:110985530"/>
    <dbReference type="OMA" id="PPIMFRG"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="9"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="191"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022102303.1"/>
        </source>
    </evidence>
    <sequence length="922" mass="102857" checksum="96384FFFDD19CABB" modified="2022-01-19" version="1">MEPSRAPLDDIAVSILAGKLGKEWKQLALRIGVTAEKLDTIRANNPLHTINQIIEMLLTWRRMQGRDDDVVSILAEALKSVGRTDLAEEMLADQKTSTSSTNFDIRALRAELIEHYKNTTCKVPTHPLFPAWVRDMSEIYVDLYMADKNDQSHRQSPRSADPPERDSLQGSEKARLQSHGELVGLDGPGKYRVLLKGKPGSGKSTVIKKVTYDWSSLEDWEEEKSQSEAEAVKPHQEQPEKLRSSFSKFTLLFPLKLNKMINDTGIVDSICGQILARDTKVSKVGLKDYIESQQEKVLFLLDGLDELPASVFEEREGDNYLMDVLKGRALRRCCVIVTSRHHRASQLLKCYPHFACVEITGFAPKERDSYIKKYFASLQNQAQLISEMEASTSLRHLAEIPLLLLMMCLVWEAESGLPKRLTELYENVVEILLMHQATKHGVPLSNQSQLPHQLMNRLGQVALQGLLDSGGERLVFSADDFSQEDIVKACDIGLLISDTVAAGLKAESTVSFLHKSFQELCAAFYLAELAKTSKKQFKKYIKCITVDRVGDMEYLLRFCCGKSTQAAKMILRHVQKLEKHNLYFERSQSQRLRLMLAFEAGSKKLASFLSDVTSFPNLKGEDLLAANCFLQNVRCLTSVKKLSVECTSSTEMSLLMAMLSHTPNLQDLICHKGPQGTPGEETSVQIPCLRKLTTVYFFDNPASRSSGQTSSLVPRFISQQVNMTHIHLLGIDMHGWMGSLRPHARAVVSLSLTNSGLLTADINILCDILSGASSLKALTLSGNSLHGLFQNLVFIGPSLEMLELSKCGILDDDVESLAKLLSAAQSLKRLSLSNNNMHGRLNVLAPVVPHLDTLHLDYCGLKDSDADTLSMLLPSAENLRKLHLLHNDFGNTDDIKFMVCMKVPGDTYLLLSYDVFGWTSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBH9</accession>
    <name>A0A8B7ZBH9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985897 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103034.1">
        <property type="nucleotide sequence ID" value="XM_022247342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBH9"/>
    <dbReference type="GeneID" id="110985897"/>
    <dbReference type="KEGG" id="aplc:110985897"/>
    <dbReference type="OrthoDB" id="10068428at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20389">
        <property type="entry name" value="Tudor_ARID4_rpt1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="1">
        <location>
            <begin position="284"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022103034.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38301" checksum="0D5BDC7B9F2DE7D5" modified="2022-01-19" version="1">MRQNTEVIPRSKLYHIATAIRHHWKMIARHVRDNETLEADFEAIILNHADPAKQALQMLLQWRERWPNVICTWESLHNALWDLNLDMIAKKCNQVYLTYKYEGSPLRQGRVKLQLGVEEPAFIPVGTDVKARYRGALCDAKVKTIEKAVQCKVRFFSDIANEVLSDDCINGDLKVGAMVEARHPTENTWMDGWIVKVTDNSIYTVVYDDGDEKTLGRSSLHLHDKNKMQRRELPFLPVGTAVKVMYRGALCEAKVKTINKSMKCRISFFDIIADAVVTDDCIKGDLKEGAVVEVRHPTPDTWMDGMIMKLADDSTYTVVFNDGDEKTLKRSSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCD6</accession>
    <name>A0A8B7ZCD6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984724</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100861.1">
        <property type="nucleotide sequence ID" value="XM_022245169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCD6"/>
    <dbReference type="GeneID" id="110984724"/>
    <dbReference type="KEGG" id="aplc:110984724"/>
    <dbReference type="CTD" id="617058"/>
    <dbReference type="OMA" id="AAAHIHC"/>
    <dbReference type="OrthoDB" id="6151791at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028001">
        <property type="entry name" value="SAXO5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34828">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34828:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15373">
        <property type="entry name" value="SAXO5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100861.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54805" checksum="1D4F13C9845052E8" modified="2022-01-19" version="1">MPSESVILPAINSIPAQLKGKDFLAASHFRIGNDKRLSRSALRRSTFTKDYVAHEHYGREAASDPPPPADVMHRDPYEGSQTTTESNAAFTGRTLPKVPMCLKLNKTNFKMDSDNRVDSFHTTHASHYYPKPLSMSFPLDNAMKSYVPQGDKDKEKMPQSDYRDNFLGHDTRVVKVERAPCMHDGGQSTIRGEDRTHKQFATSTGEQFLGRYLPYVPVKPDLLGSNIPKGDQEKLVHQDTTQLLSYPKPGTANYRVYRRDQALTRLGDTNYKAGHAKKYDKFETTAAQSFQLDQMPALTEKIPYDSNASSFPEGDRDPQRVKARVTTTNYTFYHKQPPGSFRNDIIKGANKLTASRVAFGVPSQCSAYYSTTQTDDYKTFHIPVQRVAGHGTIQSQVPLDYYGNGKEVNTSTTKDDFPSWRDVPLHEVSKEALAKLRRSNITPPLHADREFNTTHLTSYTAKRVDRYQYDSGKLQRSSVPLGTMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE59</accession>
    <name>A0A8B7ZE59_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cathepsin B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110985066</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101486.1">
        <property type="nucleotide sequence ID" value="XM_022245794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE59"/>
    <dbReference type="GeneID" id="110985066"/>
    <dbReference type="KEGG" id="aplc:110985066"/>
    <dbReference type="CTD" id="1508"/>
    <dbReference type="OMA" id="DEKIPYW"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02620">
        <property type="entry name" value="Peptidase_C1A_CathepsinB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000031">
        <property type="entry name" value="Cathepsin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012599">
        <property type="entry name" value="Propeptide_C1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08127">
        <property type="entry name" value="Propeptide_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034522296" evidence="8">
        <location>
            <begin position="18"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022101486.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="36566" checksum="E200DD39C24F8ED5" modified="2022-01-19" version="1">MHHFMILLWSLAALCQGAVFKTGPLDPFMAEAEFVNSIVTTWKAGPNFAGYSRQDVKRLMGVLTPTPEEFRLPPKTHNLGASDIPDSFDSRDKWKQCSSLNEIRDQGACGSCWAFGAVESMTDRLCIMRGVNSRISAENLATCCTSCGEGCNGGYPGAAWRYFKRTGIVTGGPYNSSKGCQPYKIPACDHHVVGRLKPCTGDDPTPKCVHKCIPSYNISYKDDLHFGENAYSIPNNVSLIQAEIMTFGPVEAAFTVYSDFPPYKSGVYKHETGSVLGGHAVKILGWGVENGVDYWLVANSWNTDWGDKGFFKILRGKNECGIEEAITAGQPAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF17</accession>
    <name>A0A8B7ZF17_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ketohexokinase</fullName>
            <ecNumber evidence="10">2.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hepatic fructokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16 17 18 19" type="primary">LOC110986199</name>
    </gene>
    <organism evidence="14 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate metabolism; fructose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.3" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022103578.1">
        <property type="nucleotide sequence ID" value="XM_022247886.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103579.1">
        <property type="nucleotide sequence ID" value="XM_022247887.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103580.1">
        <property type="nucleotide sequence ID" value="XM_022247888.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103581.1">
        <property type="nucleotide sequence ID" value="XM_022247889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103582.1">
        <property type="nucleotide sequence ID" value="XM_022247890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZF17"/>
    <dbReference type="GeneID" id="110986199"/>
    <dbReference type="KEGG" id="aplc:110986199"/>
    <dbReference type="CTD" id="3795"/>
    <dbReference type="OMA" id="MSGRLIM"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004454">
        <property type="term" value="F:ketohexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01939">
        <property type="entry name" value="Ketohexokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000018">
        <property type="entry name" value="Ketohexokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034093">
        <property type="entry name" value="KHK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="13">
        <location>
            <begin position="9"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022103578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022103579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022103580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022103581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022103582.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34247" checksum="E95E1112AB5956D9" modified="2022-01-19" version="1">MACYTEEKRILIVGLVCLDIINVLDDYPLEDTDSRVNDQLWERGGNAGNTSVVLSQLGVQTEFMGTLADNTLSQLMVEDFQQYGVHIDHCIYHKNCTPPASCIIINSSTGTRTILHNNRSLPELMYEDFELLNLKNYSWIHFEGRNIQEVLKMIDRVIMYNRELTESSERIHISVELEKPKLEVSIHKVLPKADVVFFSKDVAKAFGCQNGEECVLKFKNDAKPGAVIVCAWGELGAWAIGSDDEAVHSPAYPPAKIRDTVGAGDTFNAGVIYSISRGQSVLHAVTQGCKVAGEKIGHQGFRIGTDLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZG54</accession>
    <name>A0A8B7ZG54_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mucin-5AC-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103845.1">
        <property type="nucleotide sequence ID" value="XM_022248153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986351"/>
    <dbReference type="KEGG" id="aplc:110986351"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00083">
        <property type="entry name" value="bHLH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037644">
        <property type="entry name" value="MN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15821">
        <property type="entry name" value="PROTEIN MN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15821:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR MN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="1297"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="503"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="896"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="942"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1363"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="763"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1004"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1162"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1239"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022103845.1"/>
        </source>
    </evidence>
    <sequence length="1391" mass="149339" checksum="5AF4FEA5DD3BA910" modified="2022-01-19" version="1">MFSVGHLPSSASHEQHSSTVMTGNPVGAGGVDYGVRSVAGAGGYPSRATQAYHGGGMDAGAGFNSYGASNTADSLKGFECSDLDNALLGSGGFHSNAGSDGQMYPMPNRTMATNPANMPYGEYGHGETNTEGFGYGHMNRSHAYNRQYMSSAVYGRQTRGMNSMSNSLQQHPTNSDYSSEHMTRRMSIPAAESNVPTQSYARSNSYPVGTPYENSHNQYPSSSQSYSSMTGYNQTAFSDLDTNASNMADSQMRRTQANSYLQPYSSSAMKKPSYPTAGTGAGSEGWSDSGYSAPAKFPSHSPMSNAKALHLMDSAESSGMYPQFPHGNQNSTNTQGMQYTNTRQGTYSSVNNEITTNHYPSVNSMDICPPTSASMNYSNKIAKPFAGGSHLRQGAAYSEMATGQSRAQGYKNFQDSQASAMGQSNVSAGSQRLRHYGPMPNQNQSQGMHHLPYRAYGAADPSVNSGQSVVTPNMDGQYQNYDQFSGASSTRHERLRSLDGRFVSGAPSVQTGMGASTFPVQSQNQRSFESATQQQGVSGQSFGSTNPAYYNTRTKSDTFSPTSVQTNAGCPEMYTNQTYLEGQQRYNVMNCSSAVVNDNCPPAYQMQSDAAQTQADIRRNMIFSAELEKLARLSRDPMADDFPGGLNAISGASQIQDSVSSLPQPVKNPPYLNGTSANVAPGLFNNQGPTSVENSTSMGKSFQSPSATTTSITTNQSVKMTSAPSSVTESCAAVSSAPSTPSSNAAVAQQTSPDSNSARPIRTSPVTNPTTSTPTTVTSQDKGKDSENAVQQLQRLTQSLKEKKDDGVKGSHMEYLSHSGDGSSSIGGQNCIAALSAACRNMIADMDSSVPKLTSTSHSPLGMKSVIDNPGNILGQKYTPTPSSQTSYGPQMPEQMFSPPGASGQNISPPLVSMGDSFGSPSYSTASVPSDYQMQFSDFLEQSVPMQMNTRRPEDKPRKKGKRKKSDEVNDMLAASTIGPKKRRGRKKSSQNPLSVESFDQPPSLENLSASTPLSDGQLPLVEENSNRSATQTPNMPSNSWRTSDTKLNSSESVPSLLSNHQPPSVDSDSATQDFLDSVFSPDTTMSATNHEPVDSFSQLTCINQSHHSPASSLTSQQSMNETASTGSYSSQGGLTSRTSQNYQLDNMDQSKLAMSQAVKANRTSNSTVSSTGDLVSNPVSTSSDATDANSEMGASEEVHPLKILQAQIQLQRQQFNLNDSRPLPLKNTSRKTAGVNPTKKTGPSSVQGEVDVNVLMAEEDATWYVPSEQPKEPEVPWENTRKNAKGQQQADANPVDRRTQNKLLEQKRRDSMKNSIDNLKNALPDGRNLADQTQHSVLLKAQSFIKDMVGKQQRSKSCLEDLKSVKSRNSMLEDNIALLKQEYDILSNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIR9</accession>
    <name>A0A8B7ZIR9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine-rich repeat-containing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105533.1">
        <property type="nucleotide sequence ID" value="XM_022249841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIR9"/>
    <dbReference type="GeneID" id="110987261"/>
    <dbReference type="KEGG" id="aplc:110987261"/>
    <dbReference type="OMA" id="GWIHAND"/>
    <dbReference type="OrthoDB" id="10165987at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026137">
        <property type="entry name" value="Leu_rpt_41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15354:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15354">
        <property type="entry name" value="MUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105533.1"/>
        </source>
    </evidence>
    <sequence length="687" mass="77896" checksum="73583AC781B05BAA" modified="2022-01-19" version="1">MQFAEVASLKLLCLKQFSKMVAGNRIHLHILEEFPSRLLRDLVPVLSINDLARLHRILREKGIGVQQYWLKFYRQAFQEDRLARQCSCDDSNLASLDWRQRLLEKRCEQELLKLGPSPSEGTEEQDTLSLKILDILRNPLSTHGPLDDFFPSLVVLHSDLLPYVQRNEEIMKILQKSLRELVLTDYLPKHESILQRFLEFLIHQGVLRKFTLKNPVCETASNFFNILKVCAGVHDEIPESGCGRVAVSCCGGECCEPLRSHSESTRTKEAPCAGPPLCQISQGEAVGLQQQQDPYSSSAQPNKIIMTANHCIQHLVLCDCFFNNERDHVQMLEKLFSIWPGLRELEFANSTKSGGTSEKPCIRALIGLIRGQRPTPSLQRLRIQESSFDEHWLLCMSDLLMRSEFKTLELEGTNFRFLIRDSEGGRPCLPKDVFAHMNVVDMKYHQLVSPHYLECALLHPDCTITVLNLEYCQLRTPLVDSLFVHAKDSKCLRELSVVRNGYCPHRSHYTPAGYSGLAQLMQSGHLTKLNLGGCSFALTGWAHATDFVEALRLNFSLRQLLLEDNCLTDECLLLLATAFVNSSPETNSQASNLCLDISFNSEITHDGMDRFSQAILASTKQGRRSSRLCHLTLTKEEGENVPGVHWELAELIKLTVNHNASFMVPLNSDRGHISDYRSWTTEHQSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJL1</accession>
    <name>A0A8B7ZJL1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nuclear distribution protein nudE-like 1-A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110986136</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103481.1">
        <property type="nucleotide sequence ID" value="XM_022247789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJL1"/>
    <dbReference type="GeneID" id="110986136"/>
    <dbReference type="KEGG" id="aplc:110986136"/>
    <dbReference type="OMA" id="KTYREHA"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007100">
        <property type="term" value="P:mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="10">
        <location>
            <begin position="133"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="21"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022103481.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35883" checksum="1FE73B595C53A0A4" modified="2022-01-19" version="1">MAETPSFSTPQEEIEYWKRVADDYRKNWEEAKEELDEFQISSQELEAELETQLEAAEGKVKELTAAKERLQNETDNLKEKLEHSQNEYLRQINELQDELAQIKAIREELTKYIRELEQHNDDLERAKRTTVTSLEDFEARLNLAIERNAFLENELDEKETLEVTIQRMKDEARDMAQELAVQGKMMGGRSTQAVPDNDRMDTTPQKHGDTRLPETDNKVLHEAETNTTPGLNRVTEVGGSSGNTPLTASARISALNIVGDLLRKVGALETKLASCRNFVKDQPRRANSPVDSPRAAKRANRTGASSSTLQGMVKITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJS8</accession>
    <name>A0A8B7ZJS8_ACAPL</name>
    <protein>
        <submittedName>
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        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Eleutherozoa</taxon>
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            <taxon>Asteroidea</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJT9</accession>
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            <taxon>Valvatacea</taxon>
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        </source>
    </evidence>
    <sequence length="1370" mass="150210" checksum="919C4994C6784C6E" modified="2022-01-19" version="1">MCQSVISVFCTCTLFGFLYTSTVNILKEMDGAESTCSNEKETKGISDETKNEDGMKEGILQPPELNTGGYPSKASRHHDAFTSHQYEPRTTPVENKVMSYGRTTPLKQVEHSVSSQPSSLYGQPAWWGQDDTEKEEGQVKEKDEGGRKARTLDYAPNGKDVDAISNHPNHKYLERPTKLPLNEAEREYDIPVHVYTRPVTDLNPTTPAKRPPTPEHTEVTLVSASEKHVGFTIEFNAKDDAPKLSMNESLSEFVPAGVKSKIEGSSKMVEEMKAERMKKNLSEDPDSYQSPRMSPSAVQKLNTMWATAPGKKGARAGQGDSRSANNSEAGKVDAAKQLKMRPNISARQPVPSKSGPVKSQTSHSHHRNEDHNDHNGDNVSESGTYTIESESQSKEVLEARSKIDEVFGVGASMDAKQGSDEDTDKDVGDEEIQEEVVTMETVATQEMDVSRYLDQEYGKPGDQETAKPPFQPKPPSTGSSTAPAWVRQWAVLASKDTGHREHGLSPRSDTSQSPRDLSQGTGVQEEASSRSPNQVGQAPTAPPRRSGKRRLPATPPERGDRQSPQPTTPEDSTRANGLHVRQSPSSAFYSPRNRDRVVAPQQEEPATNDANVSWRELSTHSNPAVFVSKAGAEVGSPSTLQAREDEDFHTEVSMDTEILLKDTETFVKSLEMRMRERQRSTPSPDISESYDLSHRSFDGDIDTDLDTASCVSLVGTSGANPPRGNQASLPPSGYQGNRSAHDQRVDSKSKTPDDKNKKGSIWNRLSQPSRYKRSEKTAPSKDSSVTSDCMSDSVDSTPFRRNTSVTGSLPTGRVTGRKTPRDSESKETSPKIIHKIKANLSKPRQTRSTMLRRSRFDGKDSPGPDQGDLSPSSSISDMSSSRNSSMLRRSIPSQKESVARCQSPKDLHSRTKTTSARIDTGRPRATSRSSEQTPRSELSLGGQIVQQARSQSMRERKANAGETSARIMGKVQTSSTRTITSTSSRKNSQSSMDSSIIKKTATGAWRRYKEPETSADAVDAYIKSVTSRQSSVSSADESSIKSAPAYNYYKPHSNSSPPLQPQQHQQRTATSMQHLAGGAHYQQHRQRRSSRGEEDVAQASNSLAESLQRLAKGESTLGVAVEHIPKDELLFHFVRMMDEILAEDTVGVGGRETHPGERENYKQPLQRSTSLGYNNTEGIFARSQPSAQPGSPPVALKHKQWTKPESFDMLVMSSINHLSIKLKDSTDKVAYKLKKLQSPNATDAELAEVLKDADSPLLKTHNKEIANILKNLRQLEKRLSEIHTMIDPHDQIEVPEQLTPAAQIRRKYISDYGGAAGSTSTSTTRGSGVQSKAQQWGKSGPGSGASPGSNGPGPGDTPRSARSDESEYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZK70</accession>
    <name>A0A8B7ZK70_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Inhibin beta E chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110987211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105432.1">
        <property type="nucleotide sequence ID" value="XM_022249740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZK70"/>
    <dbReference type="GeneID" id="110987211"/>
    <dbReference type="KEGG" id="aplc:110987211"/>
    <dbReference type="OMA" id="LNYCVGQ"/>
    <dbReference type="OrthoDB" id="5949851at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13752">
        <property type="entry name" value="TGF_beta_INHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034988928" evidence="8">
        <location>
            <begin position="27"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="9">
        <location>
            <begin position="349"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022105432.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="51895" checksum="48585B72C5D7E260" modified="2022-01-19" version="1">MVALFFQLIVVLSFQLIFPHVHLVYAGVPAGQGYLTVDNAGDQPHKSPEQIDNVKSVSPTTGLIASRQSRSLAGRHVEDLPDDESRSPVHPQKPNDSNKNRSEMRKDFSEDETFNPQPSATSDHFGSGNSSESLSPTPHPSSVVSSSTREDIERRARLEMLKRTFLDQLGLVKPPIVTRPKPEVPAVVLNRLMHDAERNNQRPHRLTNSHPSQLVVFADRDEVDCGPDVAEGTCFRFSVPEQTDNSVVFSSHLWVYITHAPGGASVFVGRPQHHYDSRRRVLASRKLYSREGWVELEIPVDKHKWNRHYHYFEISTKPLQAGGNRTVAMETQHRPMLLLAMAKADRSGRVPRSVGQCTTGQTSCCMRDFLVNFTVIGWDSWIVQPLTFDAHYCAGECSVSSRHFLKDHTEIIALLLQHQEAASDMKLCCVANDVSDLSVIYLGNDNAVRQRYIDVVVENCGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZK92</accession>
    <name>A0A8B7ZK92_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987478</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105924.1">
        <property type="nucleotide sequence ID" value="XM_022250232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZK92"/>
    <dbReference type="GeneID" id="110987478"/>
    <dbReference type="KEGG" id="aplc:110987478"/>
    <dbReference type="OMA" id="ADLIWHR"/>
    <dbReference type="OrthoDB" id="5829348at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105924.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47304" checksum="BABEC78515ED9734" modified="2022-01-19" version="1">MGCGNSSETEGRKEEEHGFFHRRPKVSIRVGPHVGLEEVSKDETLVVFVFGGPGSKKGRIVDDLIHMYGFRALIAEDLILKELPKKVQNVMAIESTRGLAEMLKDNQSLLSLEWILDLIGNEIEKDPKRPHIIDIMPNLRFLLRCEKYIQDPEYDMKNFEKRFHNVFALNLAIPEEKVIKQITAHSAKHPDKMKEAGQSDEADTSRTQRRNALYNASVKHFLHYFASSGRLVTVDVACGVADLIWHRVSDFFGHQLELEPIRTVNTVVIFAFDALDFEGLDMDRYALQLVALKNLMDDSNAPPDKVLAALCRHIDASAPLVEAFAVDATDTTLLSYTAERKTRSTRFVEQAETYLDKYIFISNLKKTRGRKCSLFQRLYKVVATTQNEVCLFPQETDTELCKRIALFMAEERTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKA3</accession>
    <name>A0A8B7ZKA3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase family member 11-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110987552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106053.1">
        <property type="nucleotide sequence ID" value="XM_022250361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKA3"/>
    <dbReference type="GeneID" id="110987552"/>
    <dbReference type="KEGG" id="aplc:110987552"/>
    <dbReference type="OMA" id="CSMATEC"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053998">
        <property type="entry name" value="ACDH-11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22217">
        <property type="entry name" value="ACDH-11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="6">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="113"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase 11-like C-terminal" evidence="7">
        <location>
            <begin position="279"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022106053.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="44703" checksum="9E7AC23592678DC0" modified="2022-01-19" version="1">MTEKRGGSDVADGTETVAVKQTDGSFKLYGFKWFSSATDSDIALTLARIVDKDGNYTQGTKGISLFYVETRNKYDQLNGIQIQKLKNKLGTRQLPTAELLLDGTVAQLVSDEGRGVAAISSMLTVTRIHNAISSAGAMRRVVHLARDYSQKRHAFGKLIASHPLHMQTLSRMEVETRGNLLLVLRLCHLLGIEECGDATEQDKLLLRLLTPVAKLYTAKQAISIASEGLESFGGQGYIEDTGLPVILRDAQVLSIWEGTTNILSLDVLRSIAKTSGGSLTSFFSDIQSRLIPLVTSSDLDIRWCYEQINKACREISSFVDLSNKHQSLMPVAARDFANSLARTYIASLLLEHASWDKAKELDIAVARRWCEQCLCPVAANSVSGAYTPEGLHKDTQIVMDGYNQSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKI7</accession>
    <name>A0A8B7ZKI7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Histone acetyltransferase</fullName>
            <ecNumber evidence="20">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110987523</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>propanoyl-CoA + L-lysyl-[protein] = N(6)-propanoyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54020"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13758"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:138019"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:54021"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the MOF/KAT8, MSL1/hampin, MSL2L1 and MSL3L1. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BACC1, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MOF/KAT8, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with the chromodomain of MORF4L1/MRG15. Interacts with ATM (via its Tudor-knot domain); possibly regulating the activity of ATM. Interacts with NELFD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="20"/>
    <dbReference type="RefSeq" id="XP_022106004.1">
        <property type="nucleotide sequence ID" value="XM_022250312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKI7"/>
    <dbReference type="GeneID" id="110987523"/>
    <dbReference type="KEGG" id="aplc:110987523"/>
    <dbReference type="OMA" id="DSPEGNN"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072487">
        <property type="term" value="C:MSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903108">
        <property type="term" value="P:regulation of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000039">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF82">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="21">
        <location>
            <begin position="166"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="19">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00062668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022106004.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="52619" checksum="2432F256F6582FA4" modified="2022-01-19" version="1">MAESQGNEAAKNAVETQPVMRSNLAEGKENVQHSGGSKIIDFEEQSSDIKIGETCLVRRTNDTWHNAEIVQTRSNEMEGGRREFYVHYKGLNRRMDEWIGTDKLNIVQEQSDVKTGESAVIFDDQPDRKITRNQKRKHDEINHVQKSYAEMDPTTAALEREHEAITKVKYVDRVQIGRYEIDSWYFSPFPEDYGKQPRLWICEYCLKYMKYEKTFRRHLGECTRRQPPGREIYRKGSISVYEVDGKDHKVYCQNMCLLAKLFLDHKTLYFDVEPFLFYVLTEVDRQGAHLVGYFSKEKESPDGNNVACILILPPFQRKGYGKFLIAFSYELSKYEGTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFKGTLSIRDLSNMTSIAQNDIITTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKRPRLTVDTSCLRWAPPRKANNKIVKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM25</accession>
    <name>A0A8B7ZM25_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine-rich secretory protein LCCL domain-containing 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106668.1">
        <property type="nucleotide sequence ID" value="XM_022250976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM25"/>
    <dbReference type="GeneID" id="110987858"/>
    <dbReference type="KEGG" id="aplc:110987858"/>
    <dbReference type="OMA" id="CVEASKF"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034341904" evidence="1">
        <location>
            <begin position="24"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="39"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106668.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24600" checksum="EC359AAC222AAC7D" modified="2022-01-19" version="1">MLRFGDVFFLLGLYLFWGAGVNARVDADGTYTAVSLTPEEKDVFLNAHNELRSNVDPEAANMMFMNWDKSLALMAQAWSAKCIWDHGQPTPNISPFTSLGQNMYLITGYGNRPSGRAVSTFWYNENRHYTFETDACSGVTCDHYTQLVWAKSRSLGCGMAFCKSVSNTKWRDVWIVTCNYGPRGNTAGHKPYKPGPKCSKCKSGFGECYNGLCRAPDSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNW3</accession>
    <name>A0A8B7ZNW3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galanin receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110988250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107278.1">
        <property type="nucleotide sequence ID" value="XM_022251586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNW3"/>
    <dbReference type="GeneID" id="110988250"/>
    <dbReference type="KEGG" id="aplc:110988250"/>
    <dbReference type="OMA" id="GETEVTH"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="42"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022107278.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40849" checksum="441AB539373242D6" modified="2022-01-19" version="1">MEGVGPTVASDEQEGWGVGVEIENSILVRTSYGLICTVGIIGNLLVCLVMLRVPSLRSNTSDFLVHLAIVDFMTCLWAVLFHLFTYTPSPSGGWGGEIRCRMFDSKFPLWTSMLVSVFNLAVVNLQRYVAIVHPHKYKTLFQPRNKYLILLGCWCLALLCNWYYFIIYDVFDGTTACLFVGWGNFALQAVAGVYIFTAYLLAPLSIMVITQWRVISSLNQQVKQLKEKRQRSDGGQEVNHAKERQMWQLRTSKELQKTLLVVIIAYVVCWTPTNVVYFAFNLGAPVNFAAPYFHFCAILSISNSCINPIIYTMKNRSFRKGIKQLFWCSCGAGGDQIQPQGTDSLKIVDVIEVAGETEVTHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPW3</accession>
    <name>A0A8B7ZPW3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/arginine repetitive matrix protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107092.1">
        <property type="nucleotide sequence ID" value="XM_022251400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPW3"/>
    <dbReference type="GeneID" id="110988140"/>
    <dbReference type="KEGG" id="aplc:110988140"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107092.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="35038" checksum="527F797BA7BBB570" modified="2022-01-19" version="1">MNNSRRSPQAPGRRDSASYGPGDRAGCSASGPLARLSRGDAQSQLAPKRGKILSGGSLGSCADEERSQLRESNKKDTGGLEGARRKEARQAGMAGKERKRGGQAPPAGTKCRRPRCQSPSGPPEREQAPSAEREKRARADRPRRGAPLPAVGTESEWDRRRGGTPQRVGGLPRCASKPRPLGRVEPLRVQILVVVANIRVRSSRAEWRRRPPCEQQYVGELSEDGNLVQSQRAGRRPSGGPDPEEGETGEDRRRRRSGCSRRRARQDLRRSELPLARRPSGGADHQDRRRKGPVARRAGGGAGPAAEEERAQPEEGPPGLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQB0</accession>
    <name>A0A8B7ZQB0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110988125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM124 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107075.1">
        <property type="nucleotide sequence ID" value="XM_022251383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQB0"/>
    <dbReference type="GeneID" id="110988125"/>
    <dbReference type="KEGG" id="aplc:110988125"/>
    <dbReference type="OMA" id="RCFVEIE"/>
    <dbReference type="OrthoDB" id="10011619at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029380">
        <property type="entry name" value="FAM124"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046365">
        <property type="entry name" value="FAM124_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14715:SF7">
        <property type="entry name" value="FAM124 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14715">
        <property type="entry name" value="FAM124 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15067">
        <property type="entry name" value="FAM124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM124" evidence="2">
        <location>
            <begin position="207"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107075.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45825" checksum="739608729B7832A9" modified="2022-01-19" version="1">MAQPHPDESDGIFLENELPSSKDEADYSLSVVNLTRAADIPLRYFLPKIFSPIEASMRRSCQRVSEKAPKYRLLNTDWGNRLSSIKEGPGILALVTVENKAVDQHTVSKVESHIKKLMKGTSCQLQRWEAQHILLHFEDSKDYETFGRLFLEEKLDDCEGFRVNAIEPSILTNPPRCFVEIETTQGTETRDTLMSFISYFSGAFKHVNILEVESLTPAGRSGGGEEPQDGDIPHMAITLMFSSQAQSRAAEVLKVLSAGDPWRPYRLPEPVAKELEDDNTTYFRHATLGLPLWGVKTGASESGVRLTLFVKEGSDFQQMEKFYGKVTGVSPLQQSRGTAVKRSTYPLSNRLEFTLALYQGLTPHAHENHLLYFQTNEQAIGAQKLAEDHWQLKDPENNTVLLFTTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSM9</accession>
    <name>A0A8B7ZSM9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nociceptin receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108419.1">
        <property type="nucleotide sequence ID" value="XM_022252727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSM9"/>
    <dbReference type="GeneID" id="110988838"/>
    <dbReference type="KEGG" id="aplc:110988838"/>
    <dbReference type="OMA" id="GEVWINY"/>
    <dbReference type="OrthoDB" id="6281784at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="127"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022108419.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49920" checksum="F7873E282A7D7F98" modified="2022-01-19" version="1">MFGDLDIFEAFVYGNASMTTYQLDLIMCTMLTCLVQNQSAECGANAYVLSNDPSLLLIQSNDDQATISSDAAVHAAAGGSTEMKYFHHSQFVAHITEEDVRLLEYSTIDIVVFKYMVPFIKAFGLLANLAYFFTLFRVRDLRNTANFYLANLAVADTIILINGFVPDQHEIIHTRYRSDYGNFSDAYFSFFLVSVMVLDMSLDLGKSFCTLITVERYIAICHPFKYNQIQTKKRAVMLATVAWLIPIAFGIATLVQRQSTWIYVCQIGPIGDQYDSLTGLLKNRKLQQLPLAYELVLVSVLCLVLLVNFVLYVLIIKAIRKPSPVTSETAQVSRRQKQVTLTLVVNGIFFGCYLPTAIDLVLFVVQRTHPDFMTGEVWINYADTASCAIALLILINSSINPIIFNVGSERFRKAFLEAFCCKKRPRPGNNIPLRIIRQNNAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZT84</accession>
    <name>A0A8B7ZT84_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein sel-1 homolog 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108629.1">
        <property type="nucleotide sequence ID" value="XM_022252937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZT84"/>
    <dbReference type="GeneID" id="110988941"/>
    <dbReference type="KEGG" id="aplc:110988941"/>
    <dbReference type="CTD" id="23231"/>
    <dbReference type="OMA" id="HGPAYTA"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042756">
        <property type="entry name" value="Sel-1L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44444:SF6">
        <property type="entry name" value="LAMININ G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44444">
        <property type="entry name" value="PROTEIN SEL-1 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108629.1"/>
        </source>
    </evidence>
    <sequence length="1144" mass="130624" checksum="7A830A137A356016" modified="2022-01-19" version="1">MAGPGTNSAFVYFTFFISLSTFFDSKHLAKGFVEHRNLHAPHHRDFLPNEHNKLHSDALKRSQSTFSVVIDPIKPHLSSFIHLINPVEVFDHTHHAHIEYSCSEGDLIAAQIFLQSDDIPESPLRVFHQDWTCNRYSSGTRHAYVHLTLPDWLAYRPDNLQPVAVNVISLELKIWIISKHQIVSCVRWSDLNCHDRAHVKGVYPMKMVAVYRRQRRNYDSDVCLSFDSWIKLHFLNENEFLQSELEEEILQLVDFPVALANAYGGITKDVPPFQEIGLINEQHRNRFNPKFTISMMIFLLEYCSYDLCSIMHRKSPNTNQYITPLLFLTRKGLIHVQVVLDNGQAFGMLSNYHIPLKEWVRLVYKQDGSRWTLSVSSGRNFTNVIVSGSVFPKPVHYEETEGLIHLGGSNACKAFKGFIADTWLWRTTATSREPRWNFSNPVLMEKISSYVTGCEGVQKRMLAVFEMYQKQWQAILAQNSCPSTLPSLLEFPSTSPSDTHQPVCQPWDRRPPKGYRHLWGFLRMAAINFQGYKMSFDFIGKRLHEKAAQYLAAGGLSEIPAILPFLRQASCYGNHKSSYMLGTLYAGGINVDVDLNEAYLYWLVAAEAGNRLAMLALANHHQQGLSTASTDFDLSYNYLKRLADLTVKDRERHDPNGVLTEYVRLTDTDSLKVHKGEDGDHFLWLKYQARKGIAQAQLDMARILFWGQRGIDRDVQQAVELYRLYLMDNPQDEVVHYDYGIIHLQASIARLKFWGSEGVKRDMKTAVKYYEKTVKEMPQNSVALYDYGIVLLRGQGTKKNVEKGHGPAYTALGWYAINFQHDMKAAAKYFDIAARMGHRDAMHNLGYMYKAGQYPGKPVDEAKAFLYFQKAADRGHIDSAGVIAEIYSQGSIGVERNSYSAVFWSRFVCEKNPEIGMVLRKGLDAFLAGSWGESIVYYMMVAETGVEVAQFNLAHLCEEDHDGQVFTYIQTDCTWKYYNLSSHAAEPHVISQLKMGDFYYYGQHGDQDKTIAVQYYSMAAMRRDPQALFNLAYLLEEGTEIDNTLWKSLHIPSDVYNSDDKTQLIMAVYRRCRDGGSKDSYLPCGLALLRVQLLDLWSKYTLAVKVSIALMLGIITLSYIGTALHHIRESRQQSDTPSGQSSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU74</accession>
    <name>A0A8B7ZU74_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin Nup43-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110989135</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108974.1">
        <property type="nucleotide sequence ID" value="XM_022253282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZU74"/>
    <dbReference type="GeneID" id="110989135"/>
    <dbReference type="KEGG" id="aplc:110989135"/>
    <dbReference type="CTD" id="348995"/>
    <dbReference type="OMA" id="HDGDVMD"/>
    <dbReference type="OrthoDB" id="9890280at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22652:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="225"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022108974.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="43295" checksum="8BBC4142EC34703D" modified="2022-01-19" version="1">MACVSVKFVSQKVNKVRWQPGDLQGLQPSYTFVTGSWDNDENRICLWRLPGLKKQSEKFSDFDGYPSQAANSEIDGDGIDSEPQLVYQEKHEGDVTDLKFINQDIFLASSSAGSVQAFKLMSGTQKLRRIQQWEGLHRLRSRACPCTSMAASGTDVTTAGEDGRINVLRLEHGPPIRTIDQADSCTINAVTYLKSNQVVTVNATGQMKIWDLRQPDSQPVRVFLLTGEMTALHCVDRHPTQSHLVAAGSQNSVLNMWDLRREKYPVTLFDGHEGPIWEVKFHPTFSDHLFTCSDDGSVLHWNGSGSSSASQIAAQNARSGESIYSSLGLGGLPTKPTPSSPTSPWLASDPSHQVDINHVLPSNAMPVNSLDVEADQLVCGTDGEAVFVVQNLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUB4</accession>
    <name>A0A8B7ZUB4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110988135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107086.1">
        <property type="nucleotide sequence ID" value="XM_022251394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUB4"/>
    <dbReference type="GeneID" id="110988135"/>
    <dbReference type="KEGG" id="aplc:110988135"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107086.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="21940" checksum="4CA79286CD74288D" modified="2022-01-19" version="1">MALSVPPTPGRRGREQVGPPPGWYAPTGRRAAAVQVEAPAARPRGAAAGADLSGGSKYLTGEVGSGPRAGPVFWRYAASRLATPPAAGRQPPAASRNPLRLPASGGEFDWGGTSVKGRAYPGGPGRTTCRRGGSIAAAGATSGRGAPPHGEAGVVGSSSGERRSSAEGQPAPPSGPWADPPWRRRPGKNQRQARRDSTEERVQLEEGMLELTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWR8</accession>
    <name>A0A8B7ZWR8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">S-crystallin 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110989724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109993.1">
        <property type="nucleotide sequence ID" value="XM_022254301.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109994.1">
        <property type="nucleotide sequence ID" value="XM_022254302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWR8"/>
    <dbReference type="GeneID" id="110989724"/>
    <dbReference type="KEGG" id="aplc:110989724"/>
    <dbReference type="OMA" id="YHCDRII"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="82"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109994.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24107" checksum="FD0E9F54E5A13D51" modified="2022-01-19" version="1">MARYVLHYFKFHGRAEAIRLAFKLAGVDYQEKYIQWPTEWEQNKRRYPTQQLPVLEVDGKMIGQSKAILRYVGREFGLYGNTSLEAAHIDQVIDTVDDSWAVVNDLYVGTKEEQTASTRKFLTEVTPLVYATLDRLLDLEQAGEYFVGNSITIADLFFFTTVDFVNFVSKGSNSLKKFPKLMAVKGRVADNPKVAAWLAVRPPEPPYDEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX28</accession>
    <name>A0A8B7ZX28_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110988662</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022108096.1">
        <property type="nucleotide sequence ID" value="XM_022252404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX28"/>
    <dbReference type="GeneID" id="110988662"/>
    <dbReference type="KEGG" id="aplc:110988662"/>
    <dbReference type="OMA" id="FTRSAAX"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047034">
        <property type="term" value="F:15-hydroxyicosatetraenoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016404">
        <property type="term" value="F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="24">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022108096.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25227" checksum="6C1E2F4352CAE2CD" modified="2022-01-19" version="1">GIGIADVNHNKGQETAHHLTSQYGNNKAVFLQCDVTSDQQLEDAFKKTKQKFGQLDIVCNNAGIGDERIWRKMIDINLGAVVQGTYLARKYMSKLNGGSGGVVINIASMAGLIVGPLCPVYTATKHGVVGFTRTMATFDPAFTAEDIRINTLCPSFSDTSINDKSAAPEFIDPSVRKQMISVAKLLPVSLVAEGFISLIEEDAHDKVMRVTHERGIDFHKFKKTPPMPSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY09</accession>
    <name>A0A8B7ZY09_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein strawberry notch homolog 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110989908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SBNO family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110299.1">
        <property type="nucleotide sequence ID" value="XM_022254607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989908"/>
    <dbReference type="KEGG" id="aplc:110989908"/>
    <dbReference type="OrthoDB" id="421838at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000282">
        <property type="entry name" value="Strawberry notch homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057332">
        <property type="entry name" value="SBNO_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026937">
        <property type="entry name" value="SBNO_Helicase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026741">
        <property type="entry name" value="SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039187">
        <property type="entry name" value="SNO_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706:SF30">
        <property type="entry name" value="PROTEIN STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12706">
        <property type="entry name" value="STRAWBERRY NOTCH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13872">
        <property type="entry name" value="AAA_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13871">
        <property type="entry name" value="Helicase_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25373">
        <property type="entry name" value="SBNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Strawberry notch AAA" evidence="7">
        <location>
            <begin position="309"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Strawberry notch helicase C" evidence="6">
        <location>
            <begin position="942"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="domain" description="SBNO alpha/beta" evidence="8">
        <location>
            <begin position="1258"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="735"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="821"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="849"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110299.1"/>
        </source>
    </evidence>
    <sequence length="1458" mass="161695" checksum="E0CDD3C776DA0152" modified="2022-01-19" version="1">MTCRLAMFAGIRMNGLAEEGQDLLLAALSESGLAFDEFPGADPNEQNDFDLSLLGPPDPVETEQYPTGFQTNVTDPLLEMLQQQQQELPPQQQQLQPRMQQQQLQHVQQQPALVSAPTLPQMQNLGNVVAKLTTSSDTNSGTVYVMDKNRSMTPAAPQSPSPVPSYDIKPDFFRTIATPGPPRPSPATTAIGTYQKPVGLSRIKTAPAGLSALLDSIPSTSSHPLGFIGQGSAKPLGNSPAAAATPANKGLSQKDVSRLWSNDDIKLKHVTVKVQKQDEEDIDEDEEENMGHAETYANYRPSKLKIGLPHPDPVVETSSMASVQPPNIFYRLSIPEEVIDRKQLSALQLESVTYACQQHETLLLSGERAGYLIGDGAGVGKGRTIAGIIYENYLQGRKRSIWFSVSNDLKFDAERDLRDISARILVHSLNKFKYDKISSQANGHVKKGVIFSTYSSLIGESQGNYKYHTRLKQLLNWCGKDFDGVIIFDECHKAKNLVPVGSAKPTKTGLTVLELQKQLPKARVVYCSATGASEPRNMAYMSRLGIWGKGTPFPDFQAFIQAVERRGVGAMEIVAMDMKLRGMYIARQLSFQGVTFNINEVPLSEEFKKIYNRAVSLWLAAREKFTQAADLIGAEKRMRKSMWGQFWSAHQRFFKYLCIAAKVQHAVRLAREAVKIGKCVVIGLQSTGEARTLDALEEAGGELNDFVSTAKSVFMTLIEKHFPAPNRKKTANLFGLNSNSGASSPALSESNRGIKRKRDKLSNGLSSKQPKHWWEDNSLENSPVNSNGNEASGDSDESVIMLSSSESEDDEQETSSKASSNDEDDFNPFGDNSDDDPWLTRKPKAEKTKTKKKKKKPEKRKEKAPSFYPTLPSLEGQMNSALYAAGILTKTKLPDIMSSMSPIPAATNSMLLPGMDAYERAILMKQELLDMCEDLGPCLPNNTLDELIDELGGPENVAEMTGRKGRVVSNDDGYVRYESRSEYDIPLETLNLTEKQRFMNGDKQIAIISEAASSGISLQADKRVANQRRRVHITLELPWSADRAIQQFGRTHRSNQVHAPEYIFLISELAGERRFASIVAKRLESMGALTHGDRRATETRDLSMFNIDNKYGRAALESVMKSVVDLQHAMVPPPADYKGNFLRDAREALIGVGMVVSDDKYNVPVLDKDSSNMSKFLNRILGMEVEMQNQLFAYFTATLDAIVQQAKRDGKYDMGILDIGSMAQGQKVRKLQTQTFVREFSTGTVHTELHKVSQERGLSWDNALDMWSALTKAEEGFYISSQPTNNRRTAVLVKYGTTTNAIKKKLCHVYKPNIGLQGKMESLSDLSKKYHKVLPDGAQVAWEAQYSAAEILCSHAYWRDSCKKVLVGLPCEIGLRRRNYYILAGSVLSVWDRVEKILATQPGPASKMQILRLQTDDGSKIVGIMIPSNCIVAVRNSLLEGAHTYVDNFEDNEIITLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYX2</accession>
    <name>A0A8B7ZYX2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endosome-associated-trafficking regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110989021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ENTR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108776.1">
        <property type="nucleotide sequence ID" value="XM_022253084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYX2"/>
    <dbReference type="GeneID" id="110989021"/>
    <dbReference type="KEGG" id="aplc:110989021"/>
    <dbReference type="OMA" id="DRHDRIC"/>
    <dbReference type="OrthoDB" id="6499155at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045724">
        <property type="term" value="P:positive regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903566">
        <property type="term" value="P:positive regulation of protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026757">
        <property type="entry name" value="ENTR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31259">
        <property type="entry name" value="ENDOSOME-ASSOCIATED TRAFFICKING REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31259:SF3">
        <property type="entry name" value="ENDOSOME-ASSOCIATED-TRAFFICKING REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="300"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="428"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022108776.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="65354" checksum="D8D9A4C32026856F" modified="2022-01-19" version="1">MTSLYKFRIKKSPKNQSKSVREGSNKRDQGDDKDEDPNNPFSFKEFVKKDKRKAVYYNSKEGDIDGFSPSDSEPHEDTGTTLKEPSKNLHDIFNEGKGDDDGDDDGDDDDDDDDDEIQFLDMGNQASQGSQGSSAADGKTSQRRATSSGVPNRSRGKPHRSAQSAINPAPPIPPHGHSVNADFHAHSQSGSSTDPVKAPQIIATDVDKAARGAEFVDFIYDYATKDDDQDMPERTTRSNTGTNMSNGPSKSGDRKHGRERARAHTHGHSPRKHKAAAATNKAGNTKSQLVVDYMDATVHSQDLQSPSSLSASLTSVPTLSVSNGTEVDESSLGPKPGRERARAQSHGHRKKLPKRAPEPPTKRETTQSVPEIVHAVAAENGHEGIYQSPRPQANGMAPDKSSEILAKENGESKTDYEVPLGQSMPDNVEDLMAEVTRLRSNNRQLKQELVDAKRAVEKDAKKIEGMEAEMRRLRDREVEDAKTLETMVHHVEANLKRTTERAVTAENTITKLKTEIKSLKSEIAALTTKNKKLEEGTELEELKEKSHAASIKLATAAKEADASIKQMANGVEALKLLAETLACIDRISEVPKSFGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0L1</accession>
    <name>A0A8B8A0L1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17" type="primary">LOC110990295</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022110887.1">
        <property type="nucleotide sequence ID" value="XM_022255195.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110888.1">
        <property type="nucleotide sequence ID" value="XM_022255196.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110889.1">
        <property type="nucleotide sequence ID" value="XM_022255197.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110890.1">
        <property type="nucleotide sequence ID" value="XM_022255198.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110892.1">
        <property type="nucleotide sequence ID" value="XM_022255200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0L1"/>
    <dbReference type="GeneID" id="110990295"/>
    <dbReference type="KEGG" id="aplc:110990295"/>
    <dbReference type="OMA" id="NCSAMRT"/>
    <dbReference type="OrthoDB" id="5512589at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022110887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022110888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022110889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022110890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022110892.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39917" checksum="971510E0EF73DC6A" modified="2022-01-19" version="1">MAPDKKTCAYLGSILVATIYLVTQTWNVWVPGNILRRGDQSFLASGGNAVTTNFTNYTELFQTAYHRKLDERHLNPHDFRLLLDEPMACIEPGRGHPKSVLLLVLVTSKHANFDRRQAIRETWGSLKEIRNRAIVTLFLLGKGTTSHLLKKVSAESVEHHDLLMEDFVDSYKNLTLKTMMAMKWASTHCPQASFVMKTDDDMFVSYRNLLDYLAATAAPGTGFALGRVLKGESPYRDPKSKYYVSRELYPSDVYPPWLSGGGFVLSGDMPGRIYAVSLDTKYLPLEDVYLGLCLQKLNATLTTSDRFNNMHIGYSYCRFHYIITSHRFGPAELRTVWKDLKAQRDCWFWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A198</accession>
    <name>A0A8B8A198_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110990672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111449.1">
        <property type="nucleotide sequence ID" value="XM_022255757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A198"/>
    <dbReference type="GeneID" id="110990672"/>
    <dbReference type="KEGG" id="aplc:110990672"/>
    <dbReference type="OMA" id="WIALAEW"/>
    <dbReference type="OrthoDB" id="5973910at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033772">
        <property type="entry name" value="UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF41">
        <property type="entry name" value="UNC5C-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17217">
        <property type="entry name" value="UPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Death" evidence="8">
        <location>
            <begin position="35"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="9">
        <location>
            <begin position="190"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022111449.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="62190" checksum="98FC34441E229D1D" modified="2022-01-19" version="1">MADEANGNGIQVHPDMHETAEDYGELTLHICQEIPELILHQVARGIGPEWEKLARALDFNEGEVTRMREDFSSSESPALEFLTTWKQRQDGKEDSFTKLIDALETIDKSVIAHKALKNNSAAFRSPRRKSKAVTNADTDTLQISRSTPERHLSEQLGDERRGSKEVKLCKKLTEGLSDENRLYTRHQQPYISLGYFDNRGGSLSLEKYDARLIIPPGAIPAGPPKMVYLFTSPSPVTIEGLESIEISLSSVIQCGPEGLTFEESVVLTFPHHAAITREVAPEIRMRHNDSSPGKWEEFDGNIALMNETHAILLVNHFTEFTAVGVVSPQSTKRLSVGAFGKRVEKGIERYTLRVYVWEDTPAVKESVLAKEKAEGAIPLDDFRQFEVAWSAGHLLVKLSNLAGSWNMRTRTVQIINQEAIWKQPWTSRTFHFKAPGFLWRLLLGRDLFCDVDIYQGHERADSLKTSLSVYPENATAPARVPRDDVRAEVGAEFRRQAHGVDNIIGYTGCYGLPEQKLMDLCEHLDADREDGRNWIALAEWFTSKGYRFIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1N7</accession>
    <name>A0A8B8A1N7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110990291</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110885.1">
        <property type="nucleotide sequence ID" value="XM_022255193.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990291"/>
    <dbReference type="KEGG" id="aplc:110990291"/>
    <dbReference type="OMA" id="MNECASE"/>
    <dbReference type="OrthoDB" id="10066368at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000031">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000018">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
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        </source>
    </evidence>
    <sequence length="3253" mass="352671" checksum="E7718ED324381567" modified="2022-01-19" version="1">MEVKTSLCPVVFFLVLLSLPASDACRGGRGGGTRKPPDKQPPKLKPGSCSKNLIKYAEPKSSSKTVTWKMPETEEEKVKIILEEGPHSGSRFDASDLPTSIRYSATDRNGNKDAYFCSFLVSVKIKTCPPHPPVFRGTFSCSHNYWYGSECTTSCDSGYFLETRSRIQTCQENKLWSTPQPRCAPIQCPPLSSVSCSNANYYLSICNHECSQPGYGRGPGESATRVCGADRTWTGTAATCVDKEAPKLNCSQTIREFADASQIYKNVTWDLPQVRDNSKLPINLELARGSPSQGSMFSRGSHSITYRATDEAGNTATCSFTVIVQVIQCPALQFQSGQRMMCSSSQFIFGSDCQFECQPGFVLTGSASVECQRQGNIGVWSAEQPTCEAVTCPLLTAPENGMFVGNTSCSTAYGSWCQFECHDGYQLAGSGVRRCLALAGAAEGYWDGNKAHCEEQTCPRVYIPHNAYITNQDECPAADQIPVGTTCRFACRPGHVLTGSTEVSCGTDGNWDTTFPYCEVVTCDSSELPAPQNGIKNGCPHAEELYGTVCTLICDLGFMPTKPTYVTCGDDGNGVGTWDGNTITCEAVKCDPLEVPSSPGYMPLSCTLDEVAVNDTDQMQSYGTICVALCDLGFTSSGSGSRTCLLNGQWDGVPLQCTDITPPTLMCPSDITLFAIQGTSFAEVRYEWEPIPVMDASGDVIATLASINGQPVPANRTSVFPEGIHHLVYSAVDDSSNEGGCDLTINVLVTRCPPLYGPQNSETSLVSGQGTCHNSAVYGSVCSISCDAGYTLSDGSQEVTAECVKNTASSTVGYWQGPVVECVPNMCQVPAIPSGYISGCSDQEVEYQSSCMFVCNPGYRDNRTSLSRTIRTCLADGNWTGVPPVCEAVVCPILPSLDHGTVQPSECFTQHGLPFNTQCMFTCNEGFSLNGPYSKVCTAQGVWSDARPVSCSDHQPPAFKSCPMYISAVAPPNMRQTVVYFTTPDATDNSGDVTVTSQDQRLGTGSSFVEGTTRVVYIATDAAMNRRQCDVYVTVQVQRCRPLQAPASGSLIQCPSNIYGATCSFACNEGYNLIGHSNRTCERKNINWANLINGSDNFQVEWTGASPTCSPVTCPALDDRLPAIRSGCFQYPPATELLGTTCNWYCPYGYGGVGSSRSMCLANSTWDVVDFFCEERSCPPLVPPAGMEISPPNCLNSPTFNDNCFLQCSQSGYRVDPPSYDFIRCPGNGEWSRDITTFTCIDYEDPHFILCPLDFIEYPLQGASEATVTWNVMATDNSGETPSVNCSIQQPAVLTIGEHPVSCTATDDAGNQAFCDFEVQVKVRGCRQLNPPFYGDFVTECDSTHGSTCQVRCQNGYTLQGSDTATCSRNASTGLMYWDWNGRRPACQIASCPPLPDNLIPVGGGVYPSFCRGPIPPYYGTTCHFYCRNGFTLVGSADHQRLTCLSDGTWNQHLNALNVQCQDNMPPTLRVCPGSLSGSMSGQTLGVVLSFDVPMAVDNSEAQLTLIKTPPDIDSPYNFTRDTDVSYVFTDSGGNSVSCNFSVSIQDNLSPVLEYCPPDQNVTTDQNPTPFTWHEPVFQELTGDVLEVSCSHQNGFSFRWGRHNIQCSATNLDNGKTTMCQFGVTITPHECVDLRPPRNGAKACDSWAFGRFCSMLCNENYDVSPRDIARTFLTCGPDGVWAPPPSFFPPCARRVRPGRLRVLSDLHYYSGDCSSPETEAQIKEQFISILVNQSGFHAICASYASECHVGNVGVTCGLSSSRIYRRDVSVIRDSVLDFGFEFDQLNTIFQQLSAADELPESAQKWLSDMRAKGKLPPNHHDNQRRRLPTPRPKPNTEWTRSRRSAMSHSFTITFSMDYTLPTDSTLSDLDFEEESWIGYDKLYELVDNVQVMADSGGLELAVDGMEIDPQPVLEYEEPAPSCPHGYMATDSMTCVGCPAGQFFNNDTLTCEECLIGRYQDEDQEPQFTCKFCPVGTSTVGIGSANLTDCLGICPSGHFSDTGLEPCFKCEKGSYQSEARSLSCLPCPFGQSTASIGCMDIEDCADMCPAGSFSASGVQPCTPCPHHSYQPDQGQSSCQPCPDRHITQVTGATDLSMCSVRTFCSATSCLNGGTCMEQLESFLCECPAGLTGEHCQTDVIDCQQDSCFNGGTCVDELNGFSCTCAAGYQGDDCSVTIDFCLNDPCENGGTCSNQTSGFTCTCDVGFTGVTCEEDIDECLMHPCQHNGSCHNVEGDYFCECAAGFIGENCETNIDECKSNPCQHHGTCVDGDGAYHCVCITGYSGQHCEIDIDICASNPCADGATCQDLDDRYQCACPHGYGGVHCDELLSPCDYHPCENDGVCTETSTEETGYQCECLAGFTGPDCETNMNECASEPCSNGGSCIDGVNSFECTCLEGFEGPRCEGHTDLCNPNPCHHNAVCEAEGEDYYCVCPAGLSGRDCEIQVDVCHEGETCLNGGSCAPPSMDQLCLCMVGFVGEHCEIDFDDCTSLPCANGAVCIDGVDAFTCQCLEGLLGLKEHCARLILMIALTISVCMEQAVLISLGGGTCINGLNMYSCDCPPGYSGPECEQDINECDSHPCQNGAQCIDGVNQYQCRCRPGFVGTYCSQHAQSNFDMAFRGSHPSQYITLPHAINEPLRAFTIMMWIRTTATEGVILAYTTHISGQTLDDAQFAISNPGALEVSIRGHYCSSFISVSDDHWHHLAISWDEHGGILKIYRDGQLRLIRKSMSSDAKIHGGGEFILGELRNSDNTKSHCFTGSLSNVNLWDTALIASVIQQHAQTCGFVTPGNVIAAADFMDTVFMGQIQIVTPSKCDSVDDCASNPCASGSTCIDDVNQFICQCPLGFTGQRCQTNIDDCGTDSSPCDNGGTCVDGIGTFTCQCPLGFSGQVCELKRVDGRWSEWTEWSECSRSCEGGTQTHHRSCTNPRPAYGGSTCVGPTSESQQCNTGPCPSCRHVTRPFRGNLVCQIDGQEQNCTISCWQGYSFSRAVLPFYQCGPSTNYKWSHETGDNPRLALPQCTKYRPPNKVAMEMNLEYSTNLTCDGFDPARDSLVHQTVRDKITLNVKTLSCVQDNSCSVKRAQVSGCSTQSPADHTHRRRRRRSVEPIEIAIRLERDVHVPDRENLTSEQVTSQNSTVDAANELQQAARHLISQSVSGQFAVNVDHQVYDVDTERTQAYGMQVCPHGSVRMNAQDARCVPCESGWFENHEVCYACPPGMYQSQEGSTYCQACPRGHTTVGPGATGEDDCEVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A365</accession>
    <name>A0A8B8A365_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cysteine/serine-rich nuclear protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110990616</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AXUD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111390.1">
        <property type="nucleotide sequence ID" value="XM_022255698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A365"/>
    <dbReference type="GeneID" id="110990616"/>
    <dbReference type="KEGG" id="aplc:110990616"/>
    <dbReference type="OMA" id="FHELQNC"/>
    <dbReference type="OrthoDB" id="5946974at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031972">
        <property type="entry name" value="CSRNP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023260">
        <property type="entry name" value="Cys/Ser-rich_nuc_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580:SF9">
        <property type="entry name" value="AXIN1 UP-REGULATED 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13580">
        <property type="entry name" value="TGF-BETA INDUCED APOPTOSIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16019">
        <property type="entry name" value="CSRNP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02031">
        <property type="entry name" value="CYSSERRICHNP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cysteine/serine-rich nuclear protein N-terminal" evidence="10">
        <location>
            <begin position="71"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022111390.1"/>
        </source>
    </evidence>
    <sequence length="679" mass="73421" checksum="671024735A8E30EF" modified="2022-01-19" version="1">MATFLPESTCPVPPSNKRKRSPSPSEDSCPSSPDEAGGSGGSCSNSADLATDVPKPSNDFAIRSILGPSRKKKCVSFDGVTVYYFRRSQGFTSVPSQGGSTLGMLPRHELKKSFSLCDYSKEQERIHRIILKRQLIERRQQQLLESGVTDLEDISEEEIEDELNSINISDYYFLQPIPTKQRRALLRFAGVKKVDNVEKVDLKKIRVSRESCGCDCRNICNPATCACAQADIKCQVDRLSFPCGCTKEGCGNPTGRVEFNPVRVRTHFLHTIMRLDSDRDSNGEEGPSSSDGGEEVGSASLGTPEEYTTLASCTKPCCDNSSMERENGATGYAHSLSHYNNGQGGCSTVEGNHLFPNQYGGQGVEGNIPVEVKQHLNVQDLIPRMLHYNDSNDGLLHPHHHVGLGCSDPVPSLATYSQSDDSVLTSSSDASSNDSYQYNQCGEFAFKESPTYAEISKASDICVTSSADSSFTEVPNSKLSTLDEGSDLQLGLPLCSNSTFTDLNAHITTFSGNFGDNVVTQAPPCASSSPSGYDSSMIMDSRISQTEQCHIHVDKDAVSSTTPDSTPCTTTSSYTILSALNAIDPLDETELATSKISSVAIPMGDSFAHGTTNHSEFHELQNCSSAEAVVSGMVTVNCPDVKLTQSDTSERKQSMNCFDSANKVEDQSKDEIVASPRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XEQ0</accession>
    <name>A0A8B7XEQ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Periodic tryptophan protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110973073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079234.1">
        <property type="nucleotide sequence ID" value="XM_022223542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XEQ0"/>
    <dbReference type="GeneID" id="110973073"/>
    <dbReference type="KEGG" id="aplc:110973073"/>
    <dbReference type="OMA" id="CFVPRGV"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="228"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="357"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022079234.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="56372" checksum="B95C597675055E79" modified="2022-01-19" version="1">MTSSIITCLAWVPQGAAKENPEKVQMNSDDIQALVEKSKPTHKRAAELSDEGASGSNEVTQSGVTMETEDDLAEYDLDNYDSPDSDTGGQDSFSGLAMFASNRDDPYMTLQEDEEDRDDLEDLVIQPRDNLIVAGRAQEDASCLEVYVYNEDEGTLYVHHDILLPSFPLAAEWMNFNPKDSTPGNYVAMGYMTPVIDVWNLDVVDCLEPAFTLGKRKKKSKKKAPKPTEGHTDAVLDIAWNRHVRHGLASASADNTIALWDMAQQKVLSLLTHHSDKVQTVAWHPFEAQSLASGSFDMSVKVFDCRSAHDSFKTWSLDGEIERVIWDLFQPFHFLASTDKGNVYCMDVRTDKPVFTLKAHDDAVTALSLSTEVPSCLVTASADHLYKVWDIKDNKPSLIVSKDPKMGTVNCVHCSPNSPFIFAVGGERDGMRLVDVTSHAPVHRQFSKRRRRAAQETPALVTNQSTSMHQPGSSHTSEMSVETDTAGFQKPGAREVKSTKKSKKQPPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJP5</accession>
    <name>A0A8B7XJP5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110973579</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110973579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022080180.1">
        <property type="nucleotide sequence ID" value="XM_022224488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJP5"/>
    <dbReference type="GeneID" id="110973579"/>
    <dbReference type="KEGG" id="aplc:110973579"/>
    <dbReference type="OrthoDB" id="2434995at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052787">
        <property type="entry name" value="MAVS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446">
        <property type="entry name" value="DUF3504 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21446:SF12">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="6">
        <location>
            <begin position="460"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="5">
        <location>
            <begin position="541"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022080180.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="78389" checksum="1F37780EF557E1F6" modified="2022-01-19" version="1">MADEERETAFVPTEDMDEEISELGPSDADSVNTKKQIKYAVARLEEFAKHTGTSVEALTDSELDSFLSQFYVALRRENGELYTKKSMHGIRYGLHRHFQSVRGIDINDVKVFVNSSRAYRAMMVKLKMEGKGSVKHKDPITKQDMARVISSLDVNTPQGLQDKVFVDIMVYFGNRGRENLREMKITDFVLQNDGDHKYVIHRDMLARAKREDEAYSGVMREIPGSSKCPVSTFLAFKEVLNPEVDCMWQRPKLEAPTKGPWYTNAPLGINTLATKMKTIGERAGCSVKYTNHSLRATTVTVLDAAGFVKQDVPPVRGNRPRQTERQRSARLVARTPDSDLVPAEEERCSDHVQETGRTQDEMVKKNGMEVDNPLSKSPKHPALCESSCSVNSAASSHGHQQDFSPGLPGNSTNLRNCPGFHGWKDVCYLEPLVKEITGLSLGTFNLLLPYLPKASLVQWGLSAENNLLVFLMRLKMATPFKHLAAQFGVSPATAEQVFILILVTLTDLTSGLIRWPPKSVVRSTMPAFIRRSFPHCRLITDCLEIETEALSQLFDQLLMICKLDSAFKVKALIGLTPSGYVCFVSKLFGGSISQDKLSQESSLQYFLNSGDEILSLTPDRYLPSLRGIKVHTAPVSPQFPEVSLIYREDAASLNCHFDKLQQRLRTFGILRSKVSLDLLPHLDSVLHICAALSNLETISGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLB0</accession>
    <name>A0A8B7XLB0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-2 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110973982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080947.1">
        <property type="nucleotide sequence ID" value="XM_022225255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLB0"/>
    <dbReference type="GeneID" id="110973982"/>
    <dbReference type="KEGG" id="aplc:110973982"/>
    <dbReference type="OMA" id="FMYTRIE"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="22"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022080947.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36134" checksum="504CAAAC5D526829" modified="2022-01-19" version="1">MAEPLLALRIIKTIIGVIGLIGNATVATVICKVKFMHTLTNAFICNQAVVDFLGSLFLILTSNTPAPDPFLDASDNRIACHLWLFNLFLWACFTSSTFNLLSVSCERYVAIVYPFKYVTLYSKKSVGGIMVVIWLSGFILNGAYEAALNTYRNGQCFNSDDSLELGIVFIVVKFFIPAIFMLFVYSHMTVELKISANRIGAIAPTVSASVNSTPAVPGGGAIAAHSENAEQSLLRARRNVFKTLLLVFVIFLVCWTPNQVIFFMFNFGWKLDFTGAIYIISVSLVAINSCANPFIYAFKYRQFRRAFLSLVGRRRSQDKDGTGPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLG6</accession>
    <name>A0A8B7XLG6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110973902</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022080805.1">
        <property type="nucleotide sequence ID" value="XM_022225113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLG6"/>
    <dbReference type="GeneID" id="110973902"/>
    <dbReference type="KEGG" id="aplc:110973902"/>
    <dbReference type="CTD" id="143279"/>
    <dbReference type="OMA" id="DLMSEYY"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000004">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF9">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="475"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022080805.1"/>
        </source>
    </evidence>
    <sequence length="815" mass="91565" checksum="39A4815D2356C1A3" modified="2022-01-19" version="1">MSSLRPMAGQICASCQAPISQGLQSQRATCPTCARSFPAGARRTPGVVAPLTPGGVSGDVGMYSHQAMTDSVNDRLPSLRTPSADKNDKTNKGGRFSGITNFFSSLGGGKAKGEKGNEQEMNTKGRPSSEQGLPAINPGQAMVSQSAPSLGGKGLHKGKEAILQGYTPMTLKQFKECLSKAKASENFKKVQGFYELAFSSFSHINATFMEAGKDPRSTEDPGTSQAYVSTVFKHLLEVPEEIQKTTLKAIINSLLKDMKKPRDKNDLRAYLILLQNPQFRQTSTYVIFAHLLRQVAGLCDQDHHYLVHWFKRLPNDTFRDMVSRLIQFISIRLFPPEPADLPPIGKCSWWIPSVTKVLALLNAANSLTVPNKIVYTCFYNNTLDHVDLMKEYYAWQSPNNYQTFTFCQYPFILSLQAKRTIMQKDSEQQMIMTARRSLVAKVQQRQMPNMNMLFLNLKVRRSHLVSDSLHEVARKKADLKKKLRVQFHNEPGLDMGGLTKEWFLLLLRKIFKEEYGMFTYNDKSRCFWFNPACVDCNQEFNLVGVLMGLAVYNSIILDIHFPACTYRKLLSPAVVPYNNPGAEVGRTSVTQEDLAQVNPELAHGLKELLTYEGNVEDDLCMSFQISLPVYGTVQTIDLKPDGASIPVTNENRREYVELYLKYLLNDSIYQQFAAFYHGFHSVCASNALIMLRPEEVEMLVCGSPNLDLDALEKVTTYDGFTKEDQTIRYFWEVVKAFPVALQKKLMLFATGSDRIPIGGMGEMTFKIVKVNASTSMLPMSHTCFNQLILPPYKSRRQLKHKITIAISNAEGFGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN26</accession>
    <name>A0A8B7XN26_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110974253</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081461.1">
        <property type="nucleotide sequence ID" value="XM_022225769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN26"/>
    <dbReference type="GeneID" id="110974253"/>
    <dbReference type="KEGG" id="aplc:110974253"/>
    <dbReference type="OMA" id="FILTHAM"/>
    <dbReference type="OrthoDB" id="10522622at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016719">
        <property type="entry name" value="CAMLG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15026">
        <property type="entry name" value="CALCIUM-SIGNAL MODULATING CYCLOPHILIN LIGAND CAML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15026:SF0">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR CAMLG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081461.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="39368" checksum="DD091FF3191BC8DC" modified="2022-01-19" version="1">MADISVRREARRRKLLQSSEERLQKIKQLNEKKQENFATGEPKEDSVLLAAITTPIASVNQAQSESAKEGDSITSTLPPECLQARRPHQTDVDRTTAESGDQTNNIPEFHATEEATSASVRKMFGEVEMDYEGDTEAVSSTASVAASQETSERNLKFPQESDHSPESTASVEDSDPDNCTSVAHSPHPAPSKPIPNSLLQNRSPPIPPFGNIPSSAAATSPLPSQPGTPVHVVRQDAHDPSVAADTRHFLTVREMCVVLLAILLRLSLNTDWFQSFIGQSVIIPFIALQVMFFCLSPQTQHPPSGLIVKLLSFAAVMSNIPQATIQKIQLAFSLANQFCQDLAFYLFAFILTHEIVEVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSP5</accession>
    <name>A0A8B7XSP5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/arginine-rich splicing factor 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110975115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082956.1">
        <property type="nucleotide sequence ID" value="XM_022227264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSP5"/>
    <dbReference type="GeneID" id="110975115"/>
    <dbReference type="KEGG" id="aplc:110975115"/>
    <dbReference type="OMA" id="HYARNCQ"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001074">
        <property type="entry name" value="Splicing factor, arginine/serine-rich 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022082956.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20231" checksum="C3E2E6A660DB6B50" modified="2022-01-19" version="1">MSRYEQNNCKVYVGNLSDYGNAKELEAAFGVYGPLKHVWVAKKPPGFAFVEFEEPRDALDSVKGLNDTVICSRRVEVEMATGEKRGGRNRDRRSGGYGGNYGSRYPPRRSYNDDKCYECGKPGHFARDCPYNRRQRYSRSRSRSYDRYNSRNRRYSRSRSRSRSRSYHSPYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUS5</accession>
    <name>A0A8B7XUS5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centriolar satellite-associated tubulin polyglutamylase complex regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110975525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Regulator of the tubulin polyglutamylase complex (TPGC) that controls cytoskeletal organization, nuclear shape, and cilium disassembly by balancing microtubule and actin assembly. Regulates the assembly and stability of the TPGC and thereby modulates polyglutamylation of the microtubule, which antagonizes MAP4 binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriolar satellite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CSTPP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083770.1">
        <property type="nucleotide sequence ID" value="XM_022228078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUS5"/>
    <dbReference type="GeneID" id="110975525"/>
    <dbReference type="KEGG" id="aplc:110975525"/>
    <dbReference type="CTD" id="423188"/>
    <dbReference type="OMA" id="KATPHNR"/>
    <dbReference type="OrthoDB" id="197906at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22959">
        <property type="entry name" value="DD_C11orf49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038968">
        <property type="entry name" value="CSTPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34252:SF1">
        <property type="entry name" value="CENTRIOLAR SATELLITE-ASSOCIATED TUBULIN POLYGLUTAMYLASE COMPLEX REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34252">
        <property type="entry name" value="UPF0705 PROTEIN C11ORF49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022083770.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32969" checksum="2BCB5AD5C69EC39D" modified="2022-01-19" version="1">MNVDRFSMSAEEYLASQHVLHYLADAVSQLMEHKEDNPKVNPARFLQDYFVSVQQGNHTLFREYDFVQATPHNRASFVRIFWKCFRHIGENGDLLNVREYHSLLCLLCPDFPFHLVQQTARIIFMEDAMDSLTSFADFLYAFQVQFYYEDFLQVCFSIYNRLISSAQSPREAVYIPSETSPRQEKKQPRPLDQAAPEGVDCRLFLEAVAKECSDAAYSHPPMACLRELLNSAPRVSFYGFLMGLAKSQVINDAIEMLPAKGSLYEESDQDLTSAVAKVRLPSSGTDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV75</accession>
    <name>A0A8B7XV75_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Signal peptide, CUB and EGF-like domain-containing protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110975532</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083786.1">
        <property type="nucleotide sequence ID" value="XM_022228094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XV75"/>
    <dbReference type="GeneID" id="110975532"/>
    <dbReference type="KEGG" id="aplc:110975532"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000256">
        <property type="entry name" value="Signal peptide, CUB domain and EGF like domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000037">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000002">
        <property type="entry name" value="Signal peptide, CUB domain and EGF-like domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000018">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF7">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="108"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="410"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="449"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="902"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022083786.1"/>
        </source>
    </evidence>
    <sequence length="1094" mass="120340" checksum="7CF5DAC766EFEEA9" modified="2022-01-19" version="1">MRVYSNSLPGHTVATINGGLLLRVVDDVVAAGTTLVLEVSDERLRWNNQGPIRGSMESRHLYTLSGQTALHGPVDYAVYAGFNRVPATNLRNGTGLCSATIMMVKPKEEDECNDGRHTCEENAVCTQTRRSYRCACKNGFNRQGSSCVDVDECGSKNGGCVHTCTNVPGSYNCGCLPGFILHPEGKDCIDQDECASGQHGCQHECINTIGSYQCTCPRNYFLNADGVTCSDHPGCGNANLGCGHYCVDIANDHSICQCRPGFMLAGNKKNCIPTCLHGNGECQHVCTDSPIGPLCSCHEKYNLHTDGKTCVEAYEDTHDSFPSGDAFYLETCGLNNGGCDRVCSDTPTGVLCSCPDGFELQGDGRTCRDIDECSMNNGECEYRCTNTIGDFECSCPGGYKLLRDGRSCVDVDECSVNTTCDHTCLNYPGGFRCLCDAGYQAYGITHCGDIDECSIDAGGCQHMCTNLPGSYECECQAGYRLHHNKKDCIAELSRCVPLRPPARAILSCSTSDEEETCSLRCESNSHFTSSGRRAYTYRCGDSTEYRWTNGVNATELPLLEADEALPSCSASVNAPTYHHKARFTFTAEDCELRRFTRSESVVSDFLSKKLSEIDAEGCSGLCEVNFVNLTCQSDSTRRGKRRTRARNSLIFADFEIAVRPEPPTSDCDVDCVTAKTKKKMRKTIRKLKYAINKEHLVVTFNENTEYRVTRKSFRTTSDVETACQPGHVMVKNKCVACSVGTYHDTFSSRCAPCPPGTYQDQEGQLECNKCPQADNTGIAGGSDISHCGGQCSPGEFSLDGFAPCQPCPVGTYQAENGRTHCMNCGGGLQTRAAGSTSFADCQAREKCTAGSFYDVMRHRCALCPQGTYQSQALMNYCIKCPGNTTTDGDGTTTANECKDRRCGGVIGNYMGYIESPNYPGDYPSGIECVWRVAAPKGRKIIVVVPEVFLPEEDNCGDQIVMRKTNSPLSMTTFETCKNVTRPIAFTAQTRKLWIQFKSDAFNCYSGFQIHYATYDENYEELIKDIVGDGRLYESDHHQEILKDKETLTALLEVIAQPETYYKYSHEESMNMLPDSFIEFLRGKISRRFYPITRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVI7</accession>
    <name>A0A8B7XVI7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein shisa-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084030.1">
        <property type="nucleotide sequence ID" value="XM_022228338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVI7"/>
    <dbReference type="GeneID" id="110975667"/>
    <dbReference type="KEGG" id="aplc:110975667"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034435073" evidence="2">
        <location>
            <begin position="42"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022084030.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16339" checksum="2E57A147E1A125A8" modified="2022-01-19" version="1">MLAFWETQSHLVKSIMAGHKLAHRFLVVCFVLLVLSNGAVADLEDYFYNAIDEFEKPYYDHAVKLTTGVIIGIGVGGFAFVVLVIVLCACCCYHCCCKSRPPATNTVVVTGTQPQQQPVMIMQQPVAYDHSSVPPYPGQQASYNYAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVK6</accession>
    <name>A0A8B7XVK6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox protein Hox-B9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110975615</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083906.1">
        <property type="nucleotide sequence ID" value="XM_022228214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVK6"/>
    <dbReference type="GeneID" id="110975615"/>
    <dbReference type="KEGG" id="aplc:110975615"/>
    <dbReference type="OMA" id="NLAMRFY"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046333">
        <property type="entry name" value="HXA10/ABDB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45874:SF8">
        <property type="entry name" value="PROTEIN CBG23031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="142"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="144"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022083906.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26277" checksum="045CDFC6F88A9466" modified="2022-01-19" version="1">MQQWQATRPRCLGVTDTTVEPTLLLNYGEYDSFEDAPPVTGSCMYTTISHGAVAPPSCQHQNYYDTLAAPTASYVRSPSAIHLKYPAQTATVSSTFTDALLADDQRESEVLQSTEATSYHTSSLMDDSRHVEHSVSTSLKSGGSRPKRRPYSKLQLLHLEQEFQRCMYPSRERRSWLSQVLSLTERQVKIWFQNRRTKLKRTTEREQRENAQMQRDMANLAMRFYDPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWC2</accession>
    <name>A0A8B7XWC2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110975826 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084335.1">
        <property type="nucleotide sequence ID" value="XM_022228643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWC2"/>
    <dbReference type="GeneID" id="110975826"/>
    <dbReference type="KEGG" id="aplc:110975826"/>
    <dbReference type="OrthoDB" id="44820at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018790">
        <property type="entry name" value="DUF2358"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31094:SF2">
        <property type="entry name" value="RIKEN CDNA 2310061I04 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10184">
        <property type="entry name" value="DUF2358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034580381" evidence="2">
        <location>
            <begin position="17"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022084335.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="59235" checksum="C058696934D06D01" modified="2022-01-19" version="1">MFFWFCSARHCQFVAAMAFVRRFCTSVSELGHPHAGKQLSRKATRSSWLGTSACNPLINPALSITTGRDVSLQHIFFSRLRPTGNSSKAGTCPESLAYPFARSASGGGRSSSLHWDRRETSLMCLKDSTPSCSEGLHPPKLSPHQGEGATADELGIKDSSDREPPVLFSVERSTVNHVLSLLTSSLHVQDGLKDITATLRRLSATMHVQSIMETAAKPWDVTSSDDIIIRNNPPNEQHGANHILNNWGTGRQDSSCQNQLPSQLEAAQSLKSTEKLPALDVGVLRHAEGIHRTHLYFNKVYHVPMVAAVPEPNHLQSSTGDLQPPPAKPGSGLTKPDSSTVSPQDDNGAPKPSKEQILVMYERLEQELPNFLNESHDFSMYASTVEFDNRIMRFKTKGLPAYKASIQGLKYLCAAYVTGSTMEVLRITAELELGQIQARWRVRGVPLHSYVIRPWRRKHPDRYFDAFSTFELGSDGLIHRHKMDKVMPTPSDKVRAPSLAMRIGIALGLARNPALAPDCMVPKHLSFIQPKAGTGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWR0</accession>
    <name>A0A8B7XWR0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110976398</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with DDX21, NCL, NOP2 and EBNA1BP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085313.1">
        <property type="nucleotide sequence ID" value="XM_022229621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWR0"/>
    <dbReference type="GeneID" id="110976398"/>
    <dbReference type="KEGG" id="aplc:110976398"/>
    <dbReference type="CTD" id="9277"/>
    <dbReference type="OMA" id="EFLPYHW"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000128">
        <property type="entry name" value="WD repeat domain 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="338"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="BING4 C-terminal" evidence="11">
        <location>
            <begin position="419"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="511"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="540"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022085313.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="68289" checksum="803B87EC7B5F2F64" modified="2022-01-19" version="1">MATSIEERVLPESGNKNKRHVKKTARYFDSNVEEATTQPDPAKKHVGKFRRKGTHSEDDKQEPKWKRDFMKSREKKDPFEGPPPIPEKRMQKYVRGRKNKVTAKTMPDIRVRKKLRRYEEQQKLAAKQAARTELLLPEDSGFLEADEGEETYQITQQDISEAVDIASATKSFELKMDRFGPYRLNYTKNGRHLLLGGRLGHLAAMDWVSKKLTFEINVMESIREVRWLHLETMLAVAQKKWLYMYDNRGVEIHCIKNMNSVLRMEFLPHHFLLATANAHGVLQYLDTSIGKMISEIPTKCGRLDVMTQNPYNAIIHLGHPDGTVTLWSPSMREPVVKMLCHKAAVRAVAVDSKGLYMATAGMDRQLKIFDVRTYKPLQVYRVSYGAGDLSFSQRGLLAANLSNVIEVYKDCCTTTIDKPYMRHTLGSPISGLSFCPYEDVLGVTHSKGYASLLIPGAGEPNFDALEANPYQSKTQRREFEVKALLEKIPPELITLDPHTIGYIDSASMEQRDKERQELYGMKPPLKFEPRFKKKGRSTASKREQRKQGHKEEEKREKLRQESYKKQDEEKKRKEEKEAKKSLGYLTALDRFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWW6</accession>
    <name>A0A8B7XWW6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger matrin-type protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110975949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084530.1">
        <property type="nucleotide sequence ID" value="XM_022228838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWW6"/>
    <dbReference type="GeneID" id="110975949"/>
    <dbReference type="KEGG" id="aplc:110975949"/>
    <dbReference type="CTD" id="153527"/>
    <dbReference type="OMA" id="VDHRRKW"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Zinc finger, matrin-type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
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        <property type="entry name" value="Snu23"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="8">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="34"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <begin position="42"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="SMART" id="SM00451"/>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022084530.1"/>
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    </evidence>
    <sequence length="207" mass="24363" checksum="EBF13EBE7FC697DC" modified="2022-01-19" version="1">MASNQSSSTSRPEDHRRKWDRDEFEKLAKERLQAEEDESDSATDKKSRQPPVKRELLKQRDYKVDLESRLGKSQVITKTTPSSQMGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMKVERSTLDQVKRRFELNKRKKEEKKKDYDFESRMQELREEEAKQKAYRKEKRQERKRKAEDDDLDSGLDPDMAAMMGFSGFGSTKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XX17</accession>
    <name>A0A8B7XX17_ACAPL</name>
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        <submittedName>
            <fullName evidence="7">Acyl-coenzyme A thioesterase 9, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
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            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
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    <dbReference type="RefSeq" id="XP_022085419.1">
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    </dbReference>
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        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Acyl-coenzyme A thioesterase 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
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        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HOTDOG_ACOT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="97"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="297"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085419.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="51101" checksum="9B9BBC120DFD9C58" modified="2022-01-19" version="1">MMSSSVILRRSFGVLGRFSLPILNATTSIHPVAVRWLSENDGGMPRIKRVRKQLEELVGAQKVWSEQQQDRSDLYSQLAEKQEDLEERCMADSYQEAVIPLGEDPRCQEKYLNFYKTVRIGKIMEDLDTFAVWISYQHNRESGAKATPLVIVTALVDRIDLHEVEIKYNRDIKMCGSVTWAGKTSMEVTMHLHQKQDGVNWKKLIGARFVMVARDPDNKGAAFVHPLRAQTTEEESIIARGKKNKQLRLERSEQSLLRSAPTAEEREIIHKLFVDTLDQRSASFSTRTRPANAVWMEDSKLKNLLICFPEQRNLYNKIFGGFLMRQALELAYANAAVYSRRRPIFKSVDSIQFRKPVEVGDLLYLSSQIAYTERNYMQLRVHAEVVDPKTGERDTTNVFHFTVKSNGPVPPVQPKTYGESMLFLNGRRHFLEFLRENPEESVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY04</accession>
    <name>A0A8B7XY04_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">G-protein coupled receptor 143-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110976630</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085772.1">
        <property type="nucleotide sequence ID" value="XM_022230080.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022230081.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:dopamine binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072544">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:L-tyrosine binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001414">
        <property type="entry name" value="GPR143"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15177:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02101">
        <property type="entry name" value="Ocular_alb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00965">
        <property type="entry name" value="OCULARALBNSM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="6">
        <location>
            <begin position="40"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="129"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022085772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022085773.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="43336" checksum="5C8D58BECDD4BB4E" modified="2022-01-19" version="1">MATPTLDLVCCAFRNLSVAVKVKATNRSWVEHKEDVITFLRVFNILAILSSCLSILGAVYILFPKKSYIPRQGRSLRAVERQKKILTWLSVADVLACLGVLTIASVGLNDVDSIEWDISESPVLKWACIIITAWIQYFYVATYFWTFFYALDVNLMLRGSNRKMFRIYLVLAWLVPAIMVITGLLSMYLSSPGGSLHCDPTYKRWESLLPHYLVSYIPMLIVLIVNPVLYWFSARKVGPLLMRGNMFTDRERQIQSQVQRKFLFIILVFTFCWLPNVINGCILLNNLATYQTSWHTFGPFHAVVWSTMAVMNPLQAFLNALIYWGPGGCTQSIPSQVESDYDWTFLSNNHPDQVFSDSGEERRPLIGRPRRMRNRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYD1</accession>
    <name>A0A8B7XYD1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 136-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110976713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085908.1">
        <property type="nucleotide sequence ID" value="XM_022230216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYD1"/>
    <dbReference type="GeneID" id="110976713"/>
    <dbReference type="KEGG" id="aplc:110976713"/>
    <dbReference type="OMA" id="AIGLMEC"/>
    <dbReference type="OrthoDB" id="506011at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042512">
        <property type="entry name" value="TLCD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898:SF1">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022085908.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26261" checksum="483D966C7383DDF2" modified="2022-01-19" version="1">MDAPSGWNAAKAVLVSFVAWTTVFTVVCCLQPRRSYGWNSRIVGAIHGVTVSTMSLSTATRLNFFAAHHAVSMAGMMTSLWMGLSGTEVSAAIGLMECTNPMLQLRWFLREEGIHKGNMWYEVNDVAFVASFLTIRGVVSQYLVHCVVAHPLPARAVKFLGIAMGLMNASLVVGLVQYALKRLMAVYKAWKRGESVSESTTASKSGSSCTTFEEITIHKEFALALEYIRHHWLSHKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZ39</accession>
    <name>A0A8B7XZ39_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110976847</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022086173.1">
        <property type="nucleotide sequence ID" value="XM_022230481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZ39"/>
    <dbReference type="GeneID" id="110976847"/>
    <dbReference type="KEGG" id="aplc:110976847"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF5">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="20">
        <location>
            <begin position="8"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022086173.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="54590" checksum="75A9E9591E6BDBE3" modified="2022-01-19" version="1">MGWNPSQDILQAYYRFVVLFFNCMLTFGTAFCFDMPSVLQAIFQGNITCINATTYGNSSDCVEGLGMTPNQYNLLYAIYAWTNAIVVIAAGFLIDKLGNQVGLFLFSGLCLIGSSTFAGGAMLKGTKAMLPMMLIGRLIFGSGNGSLIIVRNRITAYWFKDKELAFAFGVTLTFVRLGSVLNFLLTKSIEDKVGLTWVLWGGAFLCALGFTSAIVTSILDIYGVRQLGQESNVKQSSKKLHFSDIRYFNSSYWLVVLTIMFFYNGVFPFMADASKFIHDKYGFKEESPVPSYLVGAVFDVSLVLCVLLGALIDIIGMRGLLALFCSVATIPVFGLLAFTHIYPLVSTLWLGFTYSIASATLWSSIPLVVTQETVGMAMGFATSAQMIGVGICNNVIGAILGNKNTPLPHDELMKRWKYVMIFLFANTLCCVVTAILLNLSDKRKGCILNQNRRERREGMALLMPSVATDDGSGNSTLAMNEAKPLLHSPDLGRPTQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y255</accession>
    <name>A0A8B7Y255_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein Skeletor, isoforms B/C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086607.1">
        <property type="nucleotide sequence ID" value="XM_022230915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y255"/>
    <dbReference type="GeneID" id="110977096"/>
    <dbReference type="KEGG" id="aplc:110977096"/>
    <dbReference type="OMA" id="NARIGPT"/>
    <dbReference type="OrthoDB" id="2448405at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052126">
        <property type="entry name" value="Spindle_Org/Thrombomodulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036">
        <property type="entry name" value="SKELETOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24036:SF5">
        <property type="entry name" value="THROMBOMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10517">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034743367" evidence="2">
        <location>
            <begin position="19"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="4">
        <location>
            <begin position="23"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="4">
        <location>
            <begin position="142"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="3">
        <location>
            <begin position="277"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022086607.1"/>
        </source>
    </evidence>
    <sequence length="657" mass="71911" checksum="F034E5B3E9239F8C" modified="2022-01-19" version="1">MQWFAGVLLLAYASISVAAPYLGRTIGDLSSRGHDVQGTVRAADAKTIVIENFHFDGTPPDSFVWIGMTAQPDASGTIVPTVPGSETKLGEYRGSNLVAYLQGPMTIKDYKWISIWCRMATANFGEVFIPGNFANPAPHDLGKLPMFAHDVEADNVRIVDARTLQFTNLFYDGNGPDAYFWANSGRSLTSQGTKLIWKPGLTNAGRNQRLDRPFNGEDFTVTMPPGMTIYDYQSFGLWCVAARQNFGSISFDPATINVPAVLEPPPTFPNCEVLVDDQFQVQWRVDFGEEDSITVELAGRVTAGNYLSFGLSGASDRTLMDGSDVVVGWMDENSMSPMVVDYNLQSKAQCSTNDGRGACPDDLNKVGGTNDVQLRDVLFGNGITRISYTRPLNTSDPIDQVIPTDRLVYISWAIGPINQDGRVAKHIMAPTGNVQINFGSGSSTCPAFKESTGGGNRLPPWPPTTLRGATKFRVEIGQSGGERGYTGITGKTGWGIAWYVNDLLIPEITVERGVQYTFEVYGGDNSEDSAKYHPFYITDDPEGGYAQKLDAQKVGVTIYAGPVEGPFCNWGENERGVNADDFDSFEAYKTKLERTCVETSANNNTFTWTPDDSTPNVVYYQCYTHRFLGWKINVNSASGLQTSLALILAMLGLVKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y385</accession>
    <name>A0A8B7Y385_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977654</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087643.1">
        <property type="nucleotide sequence ID" value="XM_022231951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y385"/>
    <dbReference type="GeneID" id="110977654"/>
    <dbReference type="KEGG" id="aplc:110977654"/>
    <dbReference type="OMA" id="TSTCADM"/>
    <dbReference type="OrthoDB" id="9991853at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087643.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="13920" checksum="0CEF8D3F960D2042" modified="2022-01-19" version="1">MPANFSGKWVSGASEGWGKFLGKFGVPVEKFPTDIQVTEEIAQSGDAINIKTSNNKDDKVKEVTINVGQNFKDTIGGGKELEFTTAWQGDKLVMTGIDGKGSMARELSGGNMIVTFTHEGVVAKSTYNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3J5</accession>
    <name>A0A8B7Y3J5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110977252</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022086890.1">
        <property type="nucleotide sequence ID" value="XM_022231198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3J5"/>
    <dbReference type="GeneID" id="110977252"/>
    <dbReference type="KEGG" id="aplc:110977252"/>
    <dbReference type="OMA" id="NILMVWN"/>
    <dbReference type="OrthoDB" id="115198at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="91"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022086890.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="48157" checksum="C4AE7C453712FF19" modified="2022-01-19" version="1">MNLAETLLAYQGKLTAITLLVLWAGTVLLVVDTRRNYTDRSTREVECPCRLQAQGNISSLAAPDRVGNASNAADDKPRTVTKWLRYCRHEKPGAPAEKDPVRPGKDGGQKVPQQQQQRPPAWKQKPDNPKKPAKKFINPHPYYFTMKNPDACKRFTNIHGYVDALCLVLTSPGDSYIRSLIRKTWASAKLVKGKRIVTMFLLGRRDTETQHFLELENNHYHDIIQENFHDSYYNLTLKTLMGLRWAAQFCPNARYILKVDVDMFVNVYNLVERLETAPTFNFAEGNRKDITEPIRDRHSKWYTSPEMYPGKTYPPYLDGPAYLVSGDLSSRVFGSSLNVRFLPWEDAYVGIIMHRIHVEPKYSGKYSSYLDYSNMQDTLRKISDSIAFHLGEDKEENKENILMVWNYVRKLNDVPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4T9</accession>
    <name>A0A8B7Y4T9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myotubularin-related protein 13-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110977966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088213.1">
        <property type="nucleotide sequence ID" value="XM_022232521.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977966"/>
    <dbReference type="KEGG" id="aplc:110977966"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13208">
        <property type="entry name" value="PH-GRAM_MTMR5_MTMR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01235">
        <property type="entry name" value="PH_Sbf1_hMTMR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14534">
        <property type="entry name" value="PTP-MTMR5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11500:FF:000006">
        <property type="entry name" value="SET binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022096">
        <property type="entry name" value="SBF1/SBF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF109">
        <property type="entry name" value="SET DOMAIN BINDING FACTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12335">
        <property type="entry name" value="SBF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UDENN" evidence="8">
        <location>
            <begin position="6"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Myotubularin phosphatase" evidence="9">
        <location>
            <begin position="1237"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="1907"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="2006"/>
            <end position="2110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1077"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1856"/>
            <end position="1884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1957"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1967"/>
            <end position="1985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022088213.1"/>
        </source>
    </evidence>
    <sequence length="2110" mass="236845" checksum="35F22F60ACECF5E7" modified="2022-01-19" version="1">MARLADYFAVVGYDHEKEQSGSSFGCGKILQRFPEKDWEDVPFISGIELFCQPGGWKLLSRALEPTFFIAVLTDIEAERHYCAVLTFSEAVKMTPTRPDDVEDEMEGALVHHTMMFAPKSLVLISRLSYFETLKNCLGLIYTAYIDSMDVPLETLVGNILGHIQVPPASGPQNLLNDCSQETVEHEWVRFSIGAGDRQALQPPLSDKLPITGTKIAMLMQQLGIRNVMCLYSAAITDQKILFHSSSYTRLTEACTALLSLLYPLKYSYVYIPILPAALTEVLSTPTPFIMGVHSSMKNEMAELMDVIIADLDGGCIMVPECINLYLPREDIFQRSHDHLTLILNPELKSADLAFPKPLETSQRVDMTDKEIRAIFLRLQAELLMGYRSCLTLIRIHPEPVITFNKGLFLFERSLVGEEFLSKVLDSMSFSTFVNDKGPPYRVCDIFDKLVANISDTLNQEEGSSEKALKNIRDVGDYLYINENPTKSTYLEKIPRPTEGAHTRINQMPFPRLKEELVGEVIEDGLNKAIVQSLNQKASKVRQQKAQIVPAGPKISSFENRMNVINNSARRLEVLRTCIGHIFDNRILDAKKLFPAVLRSLKSRVIRQALVRQLALHVQENRSVLEQQQFDMVVRLINCALQEDSCSEEYSLSMALLPLITAFCRKLCTGVIQFAYSCTQDHPVWASLQFWETAFYQDVETNIRQLYMSEHDAKCDASNGITESPGGSANGFIAASERSPLDIAAEQLRLWSGLDCEEQDKLVQNEESIVYSQAIHYANRMVCMRVPLDVTRGLKNSICMDGESGSSNLTSSSVSGSDSYNDNHFDNNSHDVSHQVVKFICRFVDKVCTEAGVASEHLKNLHTMIPGMVAMHIETLDAVNRESKRLPPIKKPKILKPTLLPGERQIMDGLRGYLLPDGREDGVGGVMGGPAYLPAEGAIFLTSYRVIFKGTPIDIQACEQVVTRSFPVSALYKEKKINVGSLANSLHLEQFMSEGLQIRSVTFQLIKIAFDEEVGAEKVEAFRKNCVRYRYPQSLYQTFAFHGSTISPLLSTQMKQKEKSATLRKFATKTFLKGKKAVGVGGGSGSSGGHHHKSKLGPQRKDRYVLPAEPLVAQRPPSAATLQRQLTAASMDSIASGSRPNSVMYEEDELSNLGLEPSLRLSRSRADSYDSDYDFDSKPRGYRSHGGSFLSVADLREAEPPVRSPKLERPRSMSIPAVIDETDVTATLKPIDVLTVDKLQKKLYVQDYYRLGFGSPGGGGMMRPKPGEAFRISEVNIHFEVTRSYPSLVVVPSALSDDSIRRLAKCHRQYRFPAITWRHPSTKALLLRSSGFHSKGVMGMISRTAQNPSTSGSSDTSTSKSLEQEKYFTAVVLNTPYGHSYKSDSLVSLNSILPPSITLEPDSTPNMGSRKGHSSGTLIQRGFMRSSGGKSGPKPGLIDRSLSTLKRGATLGKLSSFRSSGFNTGSAKNLTLAPNAVSRNGSVTDYDLGAKKDQDPRKAALYIFGEKSQSRPFKLEQFNKCDFIPYDFHETRQTKHSLKKLMKACVPSTVLTDPECGFHKLVDESEWLVQIQSIMQLAGAAVDLMDLQGSSVMFSFEEGWDFTTQVVSLAQILMDPYYRTLEGFQVLIEKEWLAFGHRFTHRSNQTMAYQASGFAPVFLQFLDCVHQVHTQFPMSFEFNQYFLKMIAFHHVSNRFQTFMLDSEYARFEAATQVFEDRKPTSEESGDLSKSRMPMRSFWEYILKINCKQPLFYNLMFAPHTPVLRPYTNISSLRIWDFFTKEDLAGGPSFDRELFDQATAEDKDMPLVPSDRRVINNCYDNVAQAELDMHMWYLEEMMQLEGDLGRTPQHWKTRLDRAQKGFPSRARRKSLSMKEAQQQSMSAHKKTTIDILVKGKNITEPQPRGFAFQHRFEAHSYMTPTDCDLCSNLLFGAVKQGCKGMKCLDCGYNAHEDCVPKVPKQCTRRGSTKEPSSGPSRPTSDEVTSAGTPVAPAGVSGYELFYAKIGETRTHEGYLYKRGARLKGWKQRWFVLDSQKHQLRYYETRNDPHYKGIIDLKEVESVQPAFPTAGAPKKCDDNAFFDLKTTRRAYNFVADTKAAAEEWISRIQDCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5G5</accession>
    <name>A0A8B7Y5G5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Reticulon-4-interacting protein 1 homolog, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110978074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088439.1">
        <property type="nucleotide sequence ID" value="XM_022232747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5G5"/>
    <dbReference type="GeneID" id="110978074"/>
    <dbReference type="KEGG" id="aplc:110978074"/>
    <dbReference type="OMA" id="VCETHPR"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08248">
        <property type="entry name" value="RTN4I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000147">
        <property type="entry name" value="Reticulon-4-interacting protein 1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037397">
        <property type="entry name" value="RTN4IP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="61"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022088439.1"/>
        </source>
    </evidence>
    <sequence length="638" mass="69826" checksum="1E45BAF5E58DDE03" modified="2022-01-19" version="1">MTASLTLNQLTSWPISMKLSLKYLSGLLQRKTKKLSNAGWTWSKPVQRPMKFLTYRFPCGPFAGHMEIDQRLAGLAGHRERNPEGYTFHRMVQEGVLNDCNVKAAIETIHDALQKLEARLADHDWLVGDQISLADYCWGPNVYCCMEEYMLGFPMGRYPAVRAWYKRLFQDEAFQRGVISYSSVPLKPVLAIKNYIQEFLGNSVSCFEREVKPNWAPSVALSVILLVSSSLLSYASITAATGVSSAALNTGLVALWLGALYSCYKKARTATKSVYFSGIHSMRALLTKSYGSEVPMVCETHPRPKVVLPDDVLVRVHAASINPIDFKMEEGYGKTALNFLRRKLKMAAGDGREFPLILGKDFSGVVEAVGESVSKVKVGDEVWGALSFVPLPGTFAEYVLVKEGLVTQKPSSLTHVQQAALSYVAMTTWGALVRAAGLSSENTAGKRVLVLAGTGGVGSFAIQLVKAWGGHVTTSCSTSGRELVEKLGADEVVDYTKIDLESALKDKPRFDVVLDSLGPASYQTCLNLCKRGGCVVTVDSPALLALDKHGLLLGIPKAIYDLCRISIPQKLFHGRSFKYGFVAPSSDALDVVAGLVEQDKIKPVVEKVYNMEDGNEALEHVRKGHARGKTVLVMKPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5Z1</accession>
    <name>A0A8B7Y5Z1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110977724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022087765.1">
        <property type="nucleotide sequence ID" value="XM_022232073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5Z1"/>
    <dbReference type="GeneID" id="110977724"/>
    <dbReference type="KEGG" id="aplc:110977724"/>
    <dbReference type="OMA" id="GMVEYWR"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="472"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022087765.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="70065" checksum="F982F85A90D3E123" modified="2022-01-19" version="1">MEQPVPRSPESEGKRRIQEEDEEEWIGPMPIEAVKPKKRKVLEFEDTFLKNLPSAELYEKSYMHRDVITHIAVSKTEYIITASCDGHVKFWKKQDLGIEFVKHFRAHLGRIGSISVSVDGTLLCTVADDKSMKIFDVVNFDMINMMKIDYVPGCCEWIFRSGDAIPALACSDKASGNIHIYDGRSSSVAVHTLSSLHSCPVIGMKYNPIFEVVLSVDKQGLVEYWTGPKKDFKFPTQVAFQYKTDTDLYEFVKCKTLPMGLTFSPNGKLFATLAKDRKVRVFKFLTGKLMRVFDESLQTFSELQQMRQQLPDMEFGRRMAAERDLQKSDAFSLANIVFDETGNFVLYATMLGIKTLNLYSNKCPRMLGKPENIRFLQLALHQGVSKPSKAALSVEMQASDNPTLVNVTSDPTLVCTAFKKNRFYLFSVREPEDAKSAEAERDVFNEKPSKEEQMAATQGTTSQRLSSQACIHTSMGDITIQLFSKECPKTVENFCVHSRNGYYNGHTFHRVIKGFMIQTGDPLGNGTGGESIWGGEFADEFHPTLRHNEPYTLSMANAGPNTNGSQFFITVVPCPWLDNKHTVFGRVTRGMDVTQKISEVKTYSKTDKPLDEIKIISISVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6F6</accession>
    <name>A0A8B7Y6F6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 883-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110978260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088793.1">
        <property type="nucleotide sequence ID" value="XM_022233101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6F6"/>
    <dbReference type="GeneID" id="110978260"/>
    <dbReference type="KEGG" id="aplc:110978260"/>
    <dbReference type="OrthoDB" id="6591996at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000702">
        <property type="entry name" value="Transcription factor E4F1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="306"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="425"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022088793.1"/>
        </source>
    </evidence>
    <sequence length="662" mass="76188" checksum="B808631040C945A2" modified="2022-01-19" version="1">MHVLSVNGRISTDFEVGNITEAPKVHLWLSREPGGGDRCIFVFADWQVGMAAHQDDDTAEKMLDHGDRSEQDDNWTGSESDRCSMESEKGPFFCEVCNVTLKTLATFKYHESKTHTGIRPFVCDVCQKAFKTAGVLKDHIRIHTGEKPFKCGICCKRFRFSSVLRVHRMEHDNIKPFACRFCHKAFRSSSHCLDHERTHTGEKPFLCSTCGKAFKTKTHLREHCKIHNKLKHNSQEQSLSYLPEQQPERSATRSIVVTTKTSTKVANVPMCQHKSKRRVCKFCSKRFKTFSYLRRHESTHKGERPYICITCDKTFQTKRNLKGHRKIHTRSRPSPCSSCTCDERSRSPVMLQVHEMDHDYIGKSVCKVCNKSFSNSSHIAQRRNTQSHNPRSKASPFLCEICNRVFIAAYQLQMHLVTHSVERPFACDVCNKTFKMQSGLTSHKRMHIVCKRVKTNVRVKKKTFKCAVCKEAFTSPGQLQEHQRVDTGEERYPCGICDKMFSKRGAREIHHMLHRKGKAGPSDNKAELQKVRNCRVQSRNTVYMGDVCDKSFECPDTRQEHRNAHNPKRPFVCEFCDKSFTTKGNLQTHVRIHSGEKPFKCDVCDCSFSFYDHLKRHKAGHNSVKPFVCKFCAKGFYRSWALKAHKRTHTGERPLLLDVGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6W2</accession>
    <name>A0A8B7Y6W2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110978337</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
            <dbReference type="ChEBI" id="CHEBI:78569"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41969"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088954.1">
        <property type="nucleotide sequence ID" value="XM_022233262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6W2"/>
    <dbReference type="GeneID" id="110978337"/>
    <dbReference type="KEGG" id="aplc:110978337"/>
    <dbReference type="OMA" id="RECALVS"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001574">
        <property type="term" value="P:ganglioside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906:SF1">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0730">Sialic acid</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022088954.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39030" checksum="C638E9A975240BE1" modified="2022-01-19" version="1">MRHWRRVGVCILTVLCIVYLLTKVGHKLTKAITKESAPSYRVTPEINGLRPYNQSDSNKQPTEIQAPSLLQNGSASTKLQTRTGAVDHYRSLLDDQPVTLHCASCALVSSSGFLLGKEAGQDIDKHPCVIRMNMAPVEGYEKDVGTRTTLRVLNFFTGVKASKLPPGSRVMIWGLYEHKADLKRVLGMLKNLRPNVIIHGQTVEGERKAGELFTKETGHPLKTNDSWLSTGWFTMMIALDLCDKLHVYGMVPAEYCVNKPKVDFPYHYYKSTSSKECATYNVSETRRGAHRFITEKAVFARWAARYNITFHYPEWTIQRDKLSDELDTPFVNKYKLNSKSLAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9G8</accession>
    <name>A0A8B7Y9G8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger MYND domain-containing protein 19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110978369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089005.1">
        <property type="nucleotide sequence ID" value="XM_022233313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9G8"/>
    <dbReference type="GeneID" id="110978369"/>
    <dbReference type="KEGG" id="aplc:110978369"/>
    <dbReference type="OMA" id="FYECHYP"/>
    <dbReference type="OrthoDB" id="2951111at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.75.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032978">
        <property type="entry name" value="ZMYND19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46831">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46831:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="179"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022089005.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26579" checksum="18ACA07F545FB2AA" modified="2022-01-19" version="1">MSAFKLGIVRLGRAAGKMKYSLLDEQDISLVERYAFEARVDVCKDGNGASVFAYTYDIQKGRNSGCYLHDLLWERHHGLIPAGLRVKHKNGVSVDNRLDNLQLTAVNPSSNSSSADSPRVLQGAELQEHSLYWIAIQQLPTDSFEEVPSVLHHYYNANGEIIEGEDESTTYYECHYPPCTKIESELREFSICGRCQEVRYCGTTCQQRDWSLHKKRCRERKKSKPYERPPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9P7</accession>
    <name>A0A8B7Y9P7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein LOC110978414 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110978414</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089094.1">
        <property type="nucleotide sequence ID" value="XM_022233402.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089095.1">
        <property type="nucleotide sequence ID" value="XM_022233403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9P7"/>
    <dbReference type="GeneID" id="110978414"/>
    <dbReference type="KEGG" id="aplc:110978414"/>
    <dbReference type="OMA" id="ELWMLKC"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF6">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="516"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="828"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="868"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="908"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="948"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="728"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022089094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022089095.1"/>
        </source>
    </evidence>
    <sequence length="1131" mass="127627" checksum="EC825D53191C0660" modified="2022-01-19" version="1">MADFDFSVVNGRRSTFQLPQKNLRYGNFEGVKALPHVGSAAVTSEQLAKTGSHFNNKRIFQKVCQWFETWMPWQKRILLCGITDRCSSSQLEYLATALEPVFHRDFSASLNKEKFSGTPPKKRQEEDPQMALLKALQMATKGTKYEGDYLLVRSGRQSRGYSDLEGFAQEYVKQVIEGALEMMYGRFSKTKPPSDHQGQFQMQQPLQPHERGESTVPPHLTLDVPKFRKLSEEECLTSESTGQLIPTITTDSDHQVQRTKRATRTLTAPPSHSYGSQSRSPARSVQDLQPPPEHCKHGRHWTFPGCQNLQTPLFSDNLTGRVATDSGTNFTPGYGTGSYAPLQANKVSTLTWCMKHQRRDRTPTSPASPGASRPASHHHNSHVSSGSVSTRDFFEHKQQSQKLGTMFRALRTGQIRKPDKLTDVSIPLQKTFKHAKWWGKEPTGTRQLVPAHHKDLKEHFKNQIAQVWVWMQDWEELEKGDLLVELIKMCDQDLLKFLADCLQQRLRHLYKWLRDRNDINCLPDKLLLHIFSFLPAHDIFMAERVCRRWRYIGAQDALWRIKCQGMGAKEGLLDLPGLIEEFNQGYSVDWRSAYTELCEVAQHAKKPAIPTAQVGETGTKKWLSIRFTEFMKKRTQTPESDKLTPIESESLSSEESSTEDFDRKHSTVVDVPIQFMKVAIEAEESDEDVIEELTMSEFAIQGLAQDFNLFPELTTTAELPAAIPFVKPTELGQPLPGRKAKEGSVDETRDEEAEGAPGVAADKTARKKKKKKKKKAARSRDDDVALDIRPELVQAKDILSELQGDVGPPMKSLKHPGWVKPIKRVRRLQGHTDAVFCLMFDKCRILTGSMDRTIRVWDIRSGRSIRKIYGHKGGIRCLQFDDTRIVSGSWDMTVMVWDIVKFDNLATLTGHVDVVSCLQFNKAHLVTGSHDSTIRVWSMDDYRSLQVLRHHRDSVTCLVFDGRFVTSGSADRTIRMASISTGECVLKLSDYLDAVTSLDVQGELIVGGTLSGKLFFWDKLSGKAVAGVQPHDSSISKIVFLPRGRGGAHFITAAGDGSIKEWDLYSMTCVRALHGHKGSVRDVKVSGDRIVSCSDDGNVRIWDLLTPPLRLGDKGEDDTIETKTIDQRQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9V6</accession>
    <name>A0A8B7Y9V6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytosolic endo-beta-N-acetylglucosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110978556</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an N(4)-(oligosaccharide-(1-&gt;3)-[oligosaccharide-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O = an oligosaccharide-(1-&gt;3)-[oligosaccharide-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:73067"/>
            <dbReference type="Rhea" id="RHEA-COMP:12603"/>
            <dbReference type="Rhea" id="RHEA-COMP:18176"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:132248"/>
            <dbReference type="ChEBI" id="CHEBI:192714"/>
            <dbReference type="ChEBI" id="CHEBI:192715"/>
            <dbReference type="EC" id="3.2.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 85 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.96" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022089337.1">
        <property type="nucleotide sequence ID" value="XM_022233645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9V6"/>
    <dbReference type="GeneID" id="110978556"/>
    <dbReference type="KEGG" id="aplc:110978556"/>
    <dbReference type="OMA" id="CYRIYHW"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06547">
        <property type="entry name" value="GH85_ENGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000043">
        <property type="entry name" value="cytosolic endo-beta-N-acetylglucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057882">
        <property type="entry name" value="ENGase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25529">
        <property type="entry name" value="Ig_ENGASE1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="11">
        <location>
            <begin position="90"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase C-terminal" evidence="12">
        <location>
            <begin position="600"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022089337.1"/>
        </source>
    </evidence>
    <sequence length="725" mass="81492" checksum="5E2D38CE7B0676F6" modified="2022-01-19" version="1">MPFYIQLCKISHAVISNKAYYCQILLLEGKYEPVTSEPICQPLKTMEDVLSWKPEGDEFNIPIAKLAARVEPREARPRTLVCHDMMGGYIDDRFVQGVPKTDCYRFYHWQYLDMFMYFSHYFVTVPPPGWTNAAHKNGVPMLGTVITEWTDGFQRCEQAFASEASYKALADKLVAIAKYYKFDGWLINIENKILPQHMPQLVEFMRYLPTKMHEQVPGSKVIWYDSVITDGSLRWQDMLNDLNRVFFDACDGIFLNYTWNAAKLASSVTAAGDRQYDVFVGVDVFGRNCFGGGGFNTNKAMSVIRQNNLSAAIFAPGWVFEKHGAEDFNANQTKFWSLLDEFLPSHGVASLPFFTNFCQGFGEMGFRNGQAVMNKAWCNLSAQQVQPTYDNHQFDHTQASNGGQRMTHSTEDGYSGGGSLLLSGNLNRKTVHTFRVFYTSLTVSHPLLVSYSVKPSQGVDSCIYLRLSSNKEKILLWTTGDSTKESQLPVSAFGLHESELLDPRLPQLSGITDQCRAFGPLVGRSHKAMQDAALRMDSQGTTSGGWNTRHYLLPENTFPADTKVTELGVMCLHKAADGSKISYSLRLGELKICDPAMLRDQMTQVTDLECLDLSWHPPLPIFSKGDAFWSLCATLRWRYAPAALHFDVYCQGVQRDPNQSRDVKETDVVFIGRAHARTFRICHLLVSKVVGSRPKSLDLIVQPTTAAGFVAPLVSATRIKVTYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA78</accession>
    <name>A0A8B7YA78_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor AP-2-epsilon-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110978520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089275.1">
        <property type="nucleotide sequence ID" value="XM_022233583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YA78"/>
    <dbReference type="GeneID" id="110978520"/>
    <dbReference type="KEGG" id="aplc:110978520"/>
    <dbReference type="OrthoDB" id="6252992at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="8">
        <location>
            <begin position="244"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022089275.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="53559" checksum="E3FB837F125EFBEC" modified="2022-01-19" version="1">MSDMSFLALDSNSWQERSDLLSSHRPGFSAASVGATSSFSPATRLSHTPTATDFQPPYFPPPYNIPQPQSQLDFHHPHVNTDPYAHLNPIHPQAQHQYMHPQQRSQHMLRSGRDDTDHLNLHHPGMQLPPSRDYSGVRRPDVLVHGGPHGLGPEQTDLAMLHHPSGLHGVDDTTRSHTCGIDVIRTVPWFMETSDCYKGAHDDGSNYIHGDHHSSVIRKAGIRQKNENGKDGLVSNVTSPNDVFCTVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRYLRERLEKIGLNLPAGRRKAANVTLFTSLVEGEAIHLARDYGYLCETEFPARQISEYIARQHNDPTEVPTRRNMVLATKQVLKELQDVLCQDRTPIGNTRPQPILEPSIQRCLTHFSLISHGFGTPALSASMATLQNVLTEMLKYMDKAFPNVTPHSAHSTSGSKIDSNSNKTNGEKADEPRNKEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YB74</accession>
    <name>A0A8B7YB74_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPI-anchored protein pfl2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110979184</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090468.1">
        <property type="nucleotide sequence ID" value="XM_022234776.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979184"/>
    <dbReference type="KEGG" id="aplc:110979184"/>
    <dbReference type="OMA" id="PIHEYNA"/>
    <dbReference type="OrthoDB" id="10040649at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034700725" evidence="4">
        <location>
            <begin position="28"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1433"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="5">
        <location>
            <begin position="1205"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1325"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1149"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1491"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1540"/>
            <end position="1612"/>
        </location>
    </feature>
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        <location>
            <begin position="55"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="179"/>
        </location>
    </feature>
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            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
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            <begin position="519"/>
            <end position="543"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="1162"/>
            <end position="1174"/>
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    </feature>
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        <location>
            <begin position="1573"/>
            <end position="1587"/>
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    </feature>
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        <location>
            <begin position="1603"/>
            <end position="1612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022090468.1"/>
        </source>
    </evidence>
    <sequence length="1612" mass="170259" checksum="C28853CEF5542C3F" modified="2022-01-19" version="1">MALGAEDWPESAIMKAHFLLMAMLVMASTSPFATQTDSSTKDTTLEVGKLTSMSSLATVNTSTPNYPNRQTQNDDPTSPSKSTTNVLKNQTTTFSTPTAEDVNGTQIQSTWKTSAVDDQLTQSDSLTNIPSDQNVTASASSTENTLTSTSFSTPMSGQTTVGSNLTNLVPTRTQSQMPSTPYHVTDDVNATSSQSSPTSIGPTPAEETVSQQDSTLFHVAGDIIEENSTVPSTNVLERNLTSTSFVSSPHVDSQMRAESNSTISVGVISANQSVTSLSPHTDETPNATLPRSTIATVKEGSTLSFGIESDILTSDVPTSKSLLADVQMTTDTNMTALSGAPSEIENVTTINSPSPFLSTLANARTSLDTNPTVSIPNNSNGPHTFVSQPSTPEKNSTPPSSTKLPTNSQSVIVIKPTTLGPNVSESQTVTTLLFSTAGSNTTSSLSTSQSPLINTQTTRKITLSLSTPDTSPGQNVTASSFQTAANISASALPVPNSTPSNISLTTAETNLVTSASNVSDSTLFKTDSKSSSSQPTSFSPVKSQPTDDIKPPTLVPNENGTAQINLTTSLSQLSNGQSTVATVSTFSVTVEKNISAPSPSMSSTQPIYNQSTVETTSTISGWNDTSNSPHTTSENSSISNQPLSKLSSSQTTLISKSTFWGNVSTPRSQPTTESDSSQQLTTEGMVLNSTTPMANISDMTLPPSNFNTSTTVWTSTNDSGSTSPFLGFSASTPVWTSTSNPDLTSPVSRFNESTPTLEKTDNSASTPPVTEVSASTHLGSSTNNLGLTSSVSRSIQSTPIEASTDNSDLTSPVPFQNASTPVRPSNNYSHFTSPVPDYNESTPVWTLTDSSNVTSPIQKETESTFNGKPLSSVIPGHNASTSPWVSSYNANNSQQYLSDPTMNSTSTIQTMSSNLPAYDSTTMSTQSSSHGSLHQTTIDMPVTAGDMTNLTSLTTTPTSAQENNATVSVFTSTFDNTSLKVTRDTLTTVTYTTLNDSLSTVRGDNESAAMSTQVTTSATIDTNTTILLQERSFEGVLRVVSFKGVSAIYNSSLEDPTSSFYQELKSSVEKFVNSIFTRSSLTRDDYLECIVRNFSNGSVVVNFGALLRPTSTVTEGDLESVATTILDVTQGTFPGSDITVDPAATSFRTTTGTPPAGPTPTISQSAFSVTPPTTEDTKYDNSSDAVSTLAVAPATNISGPTLQLEERSFEGMFRIVSWRGADAVYNSSLADPNSLFYKQLEGSIKKFVDGIYKLSLVTRDDYLGSTVRRFNNGSVLVNFGLLFRPTSTVTIANLKSLATTILEATQGTLPGTDITVDPAVTTFTLTNECELEIDDCSMYALCRDLGADGFTCQCLPGTVDTMADRPGRLCLYPTTLGPGGQITTAGLAVPTEGMHPTTPGVLSTGSSSPVPKSSVTMTTESATAGKKDEWEGWQIGLFVLGVTVGILLLAAVIYRLAVLRRHCRYAVDPERRDEQARAERAARRDRSWSFMYRRPDGDGTPDPAEYTDGGFGGSLLPADGRAVTPTAPPLETAVNEMNETGVQTDPVPGESSSHRVGGDGMDQEDDESVAHGQPTSTAQQLEESTSVDMEGNGDQEKTKNEGESTSDGCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBK5</accession>
    <name>A0A8B7YBK5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Perlucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110978902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089932.1">
        <property type="nucleotide sequence ID" value="XM_022234240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBK5"/>
    <dbReference type="GeneID" id="110978902"/>
    <dbReference type="KEGG" id="aplc:110978902"/>
    <dbReference type="OMA" id="PGGNCYK"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034417774" evidence="1">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022089932.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18600" checksum="26F78D8B6AEBB0EF" modified="2022-01-19" version="1">MNRLFLVGLLLLVVTEVLASSCPAGYYRRPGGNCYKLWTQKRKWGEANVICRTENSWLVTLNNEVESDWVNNFFISNRRHECNKWYWIGLNDISNEDVWTWISDNSPLHYSNWKNNEPNNSGNEDSVEVDCENRQWNDEDSWGNEECFICEMDTEATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YC30</accession>
    <name>A0A8B7YC30_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Serine/arginine repetitive matrix protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110979367</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090796.1">
        <property type="nucleotide sequence ID" value="XM_022235104.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090797.1">
        <property type="nucleotide sequence ID" value="XM_022235105.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090798.1">
        <property type="nucleotide sequence ID" value="XM_022235106.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="aplc:110979367"/>
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    <dbReference type="OMA" id="WLERHRH"/>
    <dbReference type="OrthoDB" id="20127at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019188">
        <property type="entry name" value="SNAPC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131">
        <property type="entry name" value="SMALL NUCLEAR RNA ACTIVATING COMPLEX, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15131:SF3">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09808">
        <property type="entry name" value="SNAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022090796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090798.1"/>
        </source>
    </evidence>
    <sequence length="731" mass="81925" checksum="CDB10EEE3D9C768D" modified="2022-01-19" version="1">METVDSEKHTGLREDIEHLLEQFLLTQNVRFQMFAEEWRKLNFTFIHFGIEKGQEKKEAMQEAFRITTEYFLPPYDLQWRVGALYILYALYMTQPHVPKFKIRISLDQWKSVASLVDTLQSQGHLDTLYVFHKMTVSKAFMFTAMPKKMIFHASYMEGKSDQNPTERWLERHRHSLMTECFDDNTLELHHGLHEQYQNTKLKLSLHDNTSLMIVRESITEYIVKRFEKLEADFEASHEVNQTSNASDSETEDRSLKISQIKARSYSTVTNETRSRRHRQQTAQSPSIPGPSTAKSKVTKSKGLPGRKGKGRATHQSSNTETSEQDENSDDETWTPHGVKKRKSQPEKNAAMSRRSQLLKSIKKVQAGITRTTEQEIINSEEDGNVEGDLTKAKKGKRHKRKQSSTDTNSDRFKATKSSSAAGGSARGRGRPKKAVTNSKQKQNKSSNRPSEQPSPNSKTPEKEAKCPRKAPQTHSTLSPQGETTKGPPPPESNQKASKEHHMDKQTVRSTDTPKKRRRSISDNSTGQKRDGFQDATPKKRLRSSDKAKDVAACNKELTKEDDIAQQGRVPRKSTKDETNSVPGTPAKKQDSTAVEASVARNSGNEGPSAKGDGILEASSRTPKQDSSPSRGHRVPPQGQGSPHQEGQSSVPKSRCLQSASTRGQSWASKTRGKRPSPVGGHKSAPKDQRSTSKEHGDSPGEQMRSLRSNITLKMRGGGIGAKTRGARQKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCP0</accession>
    <name>A0A8B7YCP0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110978623 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089441.1">
        <property type="nucleotide sequence ID" value="XM_022233749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCP0"/>
    <dbReference type="GeneID" id="110978623"/>
    <dbReference type="KEGG" id="aplc:110978623"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089441.1"/>
        </source>
    </evidence>
    <sequence length="741" mass="82168" checksum="6A9113B1B0AF8BDA" modified="2022-01-19" version="1">MEKESTPELDVTSGISEATTDGRAASTSTGDGAGPSSSLSTNGSQPAQLSEGAQASGKSGPHDLPLCLQLQARLKFSKSFEELSWDPYFESIISPLWPDRLVPSRSLPDTLTAFYLEVVEAVVKHGSGASYTDRQELMSTKLKKVGQIAFQRLLDGGELSYGTEEFSLWETLLGGTEDIVSPDESFQEYCAAYYLTSLLEDEEQSFRDHLEKIESVGVQKMISLLQFSCGLSERAANLILSHEMMHSEDKAAQILTMERSSTKLAFKLKHEGNLECEGLEELTALGSYLESNMKPPPTTLNVLRIKCKSLQDIKALAGILENSKGDFFKINIMCFLSDQGNEMLQLLEETLTTAERVLVSKRFTDRLCTCVTICIDDQSHYDARALSVCITGLSNHIWNIKVGGTSQADCCTLIDALQGCSLYSFSVCGVDMLSRVAALGSLVTLSLKQLTLSSCRLQDDDIDSLINILPAGHAFIYLDLSDNEFSLDAVKALIAHCRSFPYLCHVSLTGTGLNEDHIKQMLQQDLPQLERNNEIGLYSPFRYSSCDDIRGLKQRLQVSVVNPSHWLRIEYTLWDKGNEEAELLEKEIGKLDRWLQSRLELILIVGKLYHSTFDVERLAGSIGRISKQVERFVLNLLRHQEEIDATRILNALSGGYSLKRLEVLGVSLQGRVADIHPQVITPSMEGLSLRHCQLNDNDIESLISLLPAGHGLTELDIPFNNFSKEAMETLSTHLQSFPNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDA0</accession>
    <name>A0A8B7YDA0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17 18" type="primary">LOC110979591</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022091233.1">
        <property type="nucleotide sequence ID" value="XM_022235541.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091234.1">
        <property type="nucleotide sequence ID" value="XM_022235542.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091236.1">
        <property type="nucleotide sequence ID" value="XM_022235544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDA0"/>
    <dbReference type="GeneID" id="110979591"/>
    <dbReference type="KEGG" id="aplc:110979591"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14225">
        <property type="entry name" value="PKc_DYRK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000127">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="277"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="593"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="742"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="595"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="748"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022091233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022091234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022091236.1"/>
        </source>
    </evidence>
    <sequence length="778" mass="89055" checksum="4A25E575BFE667D0" modified="2022-01-19" version="1">MNRKLCAVVPPVPRNDGNDKKLTTSGKHSPDSPSKRNKLGWFPLHVPPGYVRRSRLAGKHKGITTVAQRSTSKVQTSSEHQSTELPARDAKGHLASDTMKYGNSKTQPLQINGMVGRKTSGTHGEKLTSSSLPPAMTKSNTSFPQLNLGPRGISNVETLPQLSNLHGNLVSTHAASEQARLHRQKTHIDRDQSKSDSPKKDGMGHRLPLTPGEALKFYRDRLTAYEQSEILDHTDIWFLGPEAKKIEGVQGAAQNNGYDDENGSYTKVLHDHLTYRYEILEVIGKGSFGQVVRAMDHKTGDTVAIKIIRNKKRFHHQALIEVKILDALRRKDKDNSNNVIHMLEYFYFRNHLCITFELLGMNLYELIKKNNFQGFSIALIRRFAYALLGCLKLLHQERIIHCDLKPENILLRQKYQNSIKVIDFGSSCYVNQRVYTYIQSRFYRSPEVILGLPYSMPIDMWSFGCILAELYTGYPLFPGENEVEQLACIMEVLGMPPTNIIEEAQRRRLFFDSKGNPRCITNSKGKKRRPNSKDLSYAIKTNNTLFLDFIERCLAWDPSQRMTPEEALQHEWIQEDKLYKSHKELTQQQIIRTSTKPKHHHHHHHGHHHGHHRHPHQHQQHKQAETDQQQQQQQAGEVEPLAASHQHQEVQQQLEQDEGDVAQRQGKVNKHQVQNNSENETVHKSKDSVERKVSVKKKSAKIRDTTHANPPKEPHQLSETTEKPINKVKPLVLDFEELLEKAPSITTEDLKESIKDSKEKDFDQVDDQPPKQFLPPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDB7</accession>
    <name>A0A8B7YDB7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable RNA-binding protein EIF1AD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 1A domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EIF1AD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090557.1">
        <property type="nucleotide sequence ID" value="XM_022234865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDB7"/>
    <dbReference type="GeneID" id="110979245"/>
    <dbReference type="KEGG" id="aplc:110979245"/>
    <dbReference type="CTD" id="84285"/>
    <dbReference type="OMA" id="PNRMQAP"/>
    <dbReference type="OrthoDB" id="1738325at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05792">
        <property type="entry name" value="S1_eIF1AD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039294">
        <property type="entry name" value="EIF1AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN EIF1AD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21641">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="7">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022090557.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22646" checksum="A2765259065CD1EB" modified="2022-01-19" version="1">MSKATKRKHVTREVLDEYTLPEDHQQIVKVTASRGNNLHEVQTATGEQFLVSMPTRFRKNVWIKRGDFVIVDPILEGDKVKAEITTILYPKQIKYIQKEGLWPDQFTSKPLHGEGEMGQPHNNQDVEVITKDLAGISLGDQAGRSDEEDSSDSDNDEDLFVNTNRPTVTYFYSDSSEEENSEEGDVGEGAGEEEKEEGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDU6</accession>
    <name>A0A8B7YDU6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Perlucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110979340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090742.1">
        <property type="nucleotide sequence ID" value="XM_022235050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDU6"/>
    <dbReference type="GeneID" id="110979340"/>
    <dbReference type="KEGG" id="aplc:110979340"/>
    <dbReference type="OMA" id="RYVICER"/>
    <dbReference type="OrthoDB" id="6337382at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034079867" evidence="1">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="41"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="172"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090742.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28967" checksum="43FFCE61A460E72C" modified="2022-01-19" version="1">MKKIYRVIAAVILSSVVTAVVGTDTCSSSATAACPPSWQPWGNSCYRFTEEKANWNQSKLACQTMGGKMAVPYSREENEFMIKMAQRGNIPLFWIGCTNTKGEGTWVCEGQGAGEPFFDWMPNRPNKNHKKIKCFIANTTYKGTGDQNDIRCCRRKRALCTFPPCTQAHHYCFATDNSRQLLKNSCLLNHVIREFMTRSNLKCASACIQEPVCRSFNIRHNDTGQKVCQLNNATRRDDPAQFQDVASFCLYAHECGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDV8</accession>
    <name>A0A8B7YDV8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: zinc finger protein 862-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091439.1">
        <property type="nucleotide sequence ID" value="XM_022235747.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979707"/>
    <dbReference type="KEGG" id="aplc:110979707"/>
    <dbReference type="OMA" id="NDHACRE"/>
    <dbReference type="OrthoDB" id="10051404at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057456">
        <property type="entry name" value="Znf_C17orf113"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006580">
        <property type="entry name" value="Znf_TTF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF9">
        <property type="entry name" value="ZINC FINGER PROTEIN 862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25431">
        <property type="entry name" value="zf-C17orf113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00597">
        <property type="entry name" value="ZnF_TTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTF-type" evidence="1">
        <location>
            <begin position="114"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091439.1"/>
        </source>
    </evidence>
    <sequence length="787" mass="87978" checksum="7EF2AFFC4707CBCF" modified="2022-01-19" version="1">MADIAFEVARPFFGRYHCIYTDKLYTSVELARRLLAEKTYLTGAVKLGSKGLPIHFSSNEEKTLITTRRTFQRDCSATIRDQRATGFAKSPLPEDAIKVGQEMQKMPENWPQEPIRSYRKEWESEFKWLSYDDNLGLMFCKLCRAANVTGDRGKKQNVFYKGSDNFKIDSIRAHVTSDNHRLAVDREKARQCTPSTSPAEVMLKSMNIAALNRLKLLFRNAHAIALNCQPFTDHQWMARLDSAKGLDVGSAYRTDKAARAFIHSIAEVERLKLIDAVQKAKFISLISDGTTDASITQAEILYIRYSDDGTPHTQLVGLHRVVKADAESITESITKGLQNTLQIYNASLKKTLVGFGSDGASVMIGRNNGVAAKMKRYSPVLQAVHCTAHRLELAFKDALKTVTLYTTLSNNLLGLYLFYRNSSKNRSGLKMAAEAQQQEVAIPTRVCGTRWLPHLQRALQQMLWDYKALITHLQQVEVEPGMSVDAKGKAKQFLKSLHXHDLMKFAHFMLDVVTVLSKVSLSAQXSSNTVAEVAASIDAAVATLAKYKTRNMTPTCKLQDFGEQGIFQGEELGGAGNISTAIGTVLTEIETSLEGRFSDMNSGVLSAMRIASFKYWPNEQDSSQVTSFDLFPKNFFTNFGDECVAAIVKHFQPVLKEADVSIDEVAVEWDLLKSRVYAKYKSISNANWPDIIRSSKHELPNICCLVDLMITIPASSADAERGFSRLKLLKTTQRTRLKDDAVSDQLMVMLHSAGIEDFDPMPAIDLWNRSSVRARHLGKPEVQADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE11</accession>
    <name>A0A8B7YE11_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin domain family 17, member A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979375</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090812.1">
        <property type="nucleotide sequence ID" value="XM_022235120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE11"/>
    <dbReference type="GeneID" id="110979375"/>
    <dbReference type="KEGG" id="aplc:110979375"/>
    <dbReference type="OMA" id="SGRESCY"/>
    <dbReference type="OrthoDB" id="2142683at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="28"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090812.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28863" checksum="4880FA65D056C51A" modified="2022-01-19" version="1">MLETGVALFVMALAICPAVLCPLGWRSGRESCYRFTPSPASWNDSRWACWEMGAEMAVPLSPQENELMREMAESAGLQKFWIGCNGLDVKGKWMCEEQEKGEPYLKWRPDELNVNDYQDCAVVLSNSKRGGVVNDRYCTQLIVAMFVRRGLCVDHPGPSTCEYRPALNSFYCFPADTNRQLLNSCLFDHVIREFVTESNPSCTSACIMEPACRSFNIKLSDQGQAFCQLSNATRCDDLDKFQDVNFICNCAQECVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEC0</accession>
    <name>A0A8B7YEC0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome maturation protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091604.1">
        <property type="nucleotide sequence ID" value="XM_022235912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEC0"/>
    <dbReference type="GeneID" id="110979820"/>
    <dbReference type="KEGG" id="aplc:110979820"/>
    <dbReference type="CTD" id="51371"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091604.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18857" checksum="15F20FA175B64AB7" modified="2022-01-19" version="1">MPFFTLSPSGCFLQFGALYLDWGGHHWKKKMTDQGFSSQPVGAVEVAHDSKNYGAPDLMLNGPTSVKESLTSSHPLEDSEKCYWDRLQQQEFHMLRKVQGLHAPLKLQMELHAARQIQRAPCLPSSNASLDTLLGRDETIGFEDYLNAPGDAEVMGNPHALMEKQFGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YII5</accession>
    <name>A0A8B7YII5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine 5'-monophosphoramidase HINT3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Histidine triad nucleotide-binding protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110980549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093043.1">
        <property type="nucleotide sequence ID" value="XM_022237351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YII5"/>
    <dbReference type="GeneID" id="110980549"/>
    <dbReference type="KEGG" id="aplc:110980549"/>
    <dbReference type="CTD" id="135114"/>
    <dbReference type="OMA" id="SINFLPC"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF5">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HINT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="10">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="8">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="7">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093043.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21289" checksum="0BEB2A6D531C207A" modified="2022-01-19" version="1">MEDLSSKFKSDVITKGKEPVIKEDCIFCKISRGEATSSVLFKNSEVTVFYDIRPAAKEHLLIIPNCHHGNPKTLTKADIPMVEYLHDVGQGVLEQKGGSLDDAKVGFHWPPFNTVEHLHLHMAYPASSMKLFSSLMYRNNSPWFVTYDWLLQRLKNLPDATSVRPEQSNPSAIKEANETIGESSGKGTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJH1</accession>
    <name>A0A8B7YJH1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Replication factor C subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Activator 1 41 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110980759</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093399.1">
        <property type="nucleotide sequence ID" value="XM_022237707.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093400.1">
        <property type="nucleotide sequence ID" value="XM_022237708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJH1"/>
    <dbReference type="GeneID" id="110980759"/>
    <dbReference type="KEGG" id="aplc:110980759"/>
    <dbReference type="OMA" id="GCQSGSF"/>
    <dbReference type="OrthoDB" id="10249205at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000032">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="65"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022093399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022093400.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39846" checksum="B501EA4604A0A7E6" modified="2022-01-19" version="1">MHAFLKGGTSSKPAAKDKAGSSGETSKARERLVPWVEKYRPRCVDDVAFQEEVVAMLKKSLEGSDLPNMLFYGPPGTGKTSTILAAGRELFGDMFRSRVLELNASDERGIDVIRNKVKTFAQQTAGGTRPDGRPCPPFKIVILDEADSMTNAAQSALRRTMEKQSKNTRFCLICNYVSRIIEPLTSRCSKFRFKPLSEDVQRKRLLDICQKEGIKCGEEAMNTIISTSEGDLRKAITFLQSAYRLRADEDITVQDIYEIGGVVPNQVMTNLMITCSSGSYEKLEKTVLDLQKEGYAATQVVTQLFDLVVERGDLTDTQKSAIMERMAIIDKRLCDGADEYLQVMDIFTHMMGQICNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKJ4</accession>
    <name>A0A8B7YKJ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110980610 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110980610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093147.1">
        <property type="nucleotide sequence ID" value="XM_022237455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKJ4"/>
    <dbReference type="GeneID" id="110980610"/>
    <dbReference type="KEGG" id="aplc:110980610"/>
    <dbReference type="OMA" id="IMSPPIT"/>
    <dbReference type="OrthoDB" id="10011215at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034595706" evidence="3">
        <location>
            <begin position="25"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="29"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022093147.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="67688" checksum="AD16711314F36EC4" modified="2022-01-19" version="1">MDMYGVLGALQPLLYLLVVSRCEASEVLYHCTFESNEDCRLEQDPSDEFDWEVHRGMAPSNHARFHSRRSRHHRSVWKRGSLRYETYSGPLSVFRELSIEERELLNNNVFIDLSPDPFPHWPFVDHTYGNDSGHFAHLVAKDNTQTSGHARIMSPEITMPDSVEADLTFFYHLWNFKGRPSAGRLKVFVCEGQDLVFTATASLGSVWMKAEVRIKCNGTFRIIFEGFIGGKDIEIAIDDVNVTVSNGTPPTVQPHTTWNTGNESNATTTSLPTTMTSAGPSNPEPGPEGPDTGVDPETAVSLVVIALVLFAATCFMLLVTLMIHIRFRSKRRRRGRFHEPFTFGSEFFNRHSMDPSEATAYMTLNFPPSSTSGSGLEFLSMSERRSCDARDSKRSKPSDGAQSKRSSGLHASAESIRRSAYTRRSTGGQRRQSRTFPVSKELKNLLESVQMRRFRTLSQHMSVADVETLRRTLSSQGETAPNSDRTVSTVLLDATASSLRKMSDMSDHFYYSLFPTVGIVSCKNSLVASEDSDQIIELKDRRPASGEYDSDDLEVQAVTSGSLLIKSESQSESESDRSVAPETTQMVDNEIYECFTNSDASSSGTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLT9</accession>
    <name>A0A8B7YLT9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110981183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022094228.1">
        <property type="nucleotide sequence ID" value="XM_022238536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLT9"/>
    <dbReference type="GeneID" id="110981183"/>
    <dbReference type="KEGG" id="aplc:110981183"/>
    <dbReference type="CTD" id="501"/>
    <dbReference type="OMA" id="DAWKVYM"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07130">
        <property type="entry name" value="ALDH_F7_AASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000018">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521:SF1">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="66"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022094228.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="58112" checksum="62810C03971DA4AC" modified="2022-01-19" version="1">MAASMLKRTASLIKTSRNLLASCSVVHAKYSSGLLVNSGKYPFLQELGIEEENAGAFTGKWGGKGELITSYSPINGEPIATVRQASLEEYDESVKNAKEAWDVWADVPAPMRGEIVRQIGDALRVKKNAIGQLLSLEVGKIVAEGGGEIQEFIDICDFAVGLSRMFAGRVLPSERPGHALLEQWNPRGHTGVITAFNFPTAVFGWNAGITMVCGNTCLWKPAPSTPLCGIAVTKVIQSVFAANKMPPAIMTLLCGGADLGEAIARDERVPIVSFTGSTPVGQKIGTIVQERFGRCILELGGNNAIIVLEDADLNLVIPATLFASVGTQGQRCTTTRRLILHENIYDEVLEKLKKAYSQVRIGDPLDENTLYGPMHSQQGVEIYQNAIQNALAQGGKLEVGGKVLERPGHYVEPTIISGLPHDAPVIQTESFAPVLYVLKTSSLEEAIGWNNEVKQGLSSSLFTKNPGNLFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYGDELPLAQGLKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLZ5</accession>
    <name>A0A8B7YLZ5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="19">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110981218</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Golgi apparatus membrane</location>
            <topology evidence="2 19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="19"/>
    <dbReference type="RefSeq" id="XP_022094288.1">
        <property type="nucleotide sequence ID" value="XM_022238596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLZ5"/>
    <dbReference type="GeneID" id="110981218"/>
    <dbReference type="KEGG" id="aplc:110981218"/>
    <dbReference type="OrthoDB" id="429263at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23441">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000020">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF119">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 19" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="20">
        <location>
            <begin position="415"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022094288.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="63214" checksum="667D3A547C43A228" modified="2022-01-19" version="1">MHAPLRMKMRSRRTLFLLLLTFVLACLLLYLRISPMKGTRHQKYDVFQVLNSRVLDIDNYLRDSREESGEDPYKRHAFNQARSDSVPIDRNIPDTRNFRCQNIDYGVENLPPTSVIITFHNEARSTLLRTVASVLNRSPSHLIQEIILVDDFSDNPEDAQILSQIPKVKVLRNDRREGLIRSRVRGADAASASILTFLDSHCEANVDWLPPLLHRVHQDNTRVVSPIIDVINLDSFKYIGASPDLRGGFDWSLHFKWEHMPVDQRSRRKNSIEPIRTPMIAGGLFVINKGWFNKLGKYDTEMNIWGGENFEISFRVWQCGGSLEIIPCSRVGHVFRKKHPYTFPEGNANTYIRNTRRTAEVWMDDYKQYFYNARPSARGKPFGNVDSRRELRKQLNCKPFQWYLENIYPELRIPKPGNVQYGKLQQGDLCLDSTPRATGTTWAPSIIPCEIQDQDQAWSLTKEDTVQQQFQCLTVSSSVPDTRVYLTTCQSNDIKQKWTREGSRLIHQLSHLCLDHLPQRGLVVRPCDPDSDTQIWTFKPPRPGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMG9</accession>
    <name>A0A8B7YMG9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC110980363</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110980363</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092671.1">
        <property type="nucleotide sequence ID" value="XM_022236979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMG9"/>
    <dbReference type="GeneID" id="110980363"/>
    <dbReference type="KEGG" id="aplc:110980363"/>
    <dbReference type="OMA" id="DVCENMW"/>
    <dbReference type="OrthoDB" id="547291at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034733587" evidence="12">
        <location>
            <begin position="21"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="41"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="148"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="489"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022092671.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="69390" checksum="494D69F042CC7F84" modified="2022-01-19" version="1">MRSSTFHLVWVMFVIVCTAPRRSMLMPGGPGPAMQYQITSARLVGPQLSRDHAHSGRVQVQIDGTTWLDVCENMWDDGDGEVACRQVGYAGLLDSMRGIRIDEANQTSESVRDFRCAGEESSLAQCDHNKRGRCMNGAGITCYEITSVRLVGPQLRDQPHSGRVQVQIDSTTWLDVCENMWDDEDGEVVCRQVGYAGLLNSMRGIGIDANNRTSESVRDFRCDGEESSLAQCDHNKRRGCMNGAGVICYDIGQETEATTIERVVTPEQTTPGPANTSPVTSSMWTVTERPENPGLTQSATDGHGMTTKLATTDTGGLDSQRESKPGKYIGLALGCTVFIVCACFMVVCLLRRYRQRKLPVATTDLQLSVGFEQCRSDNEKVLGLAVPCPSPVEHSLKQPASAPPVSRNESASKISVYLELNGEMASGKRSSTEGKQNTARASCFTTKQSESDAMETNQVLSCGTDYFTVEDKGDLTGNGQYTTGVVGDKATSQAVDAPSRDSGLPGEDDVDDHEYTYADPISGSTAHAEGEPGSHNVLHPPVYTYADVPRLGAPATGIDRPPNADYFMIEEQENSMGAPLYNAGEARPTISTKETKNAGCQPAAMNRETEYATADDSNLCTGSAEETEGWVENIVYVPGPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMK3</accession>
    <name>A0A8B7YMK3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110980919</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110980919</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093685.1">
        <property type="nucleotide sequence ID" value="XM_022237993.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093686.1">
        <property type="nucleotide sequence ID" value="XM_022237994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMK3"/>
    <dbReference type="GeneID" id="110980919"/>
    <dbReference type="KEGG" id="aplc:110980919"/>
    <dbReference type="OMA" id="EWLEWRP"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="167"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093686.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="41638" checksum="3588537F9D3330DA" modified="2022-01-19" version="1">MNEIAVRTHQGEYYAGDTVYGMIYLKVVTADFSDKIQLQISGIEQCDYTPVDGDDWSINHSNDCLRNPYTDKVMANPVEVLALKEPLPVGNYKFPFHYKLKPNLPSTTSISSPRGNWHGSVIYRVTALASNKLSDTQTFVCLGKRTNNAVKVAYLDEKIIKTCFCYDRGGLSLMAELDKLAYTIGETIQLSVNVNNKSSELAKSVKCWLKRTVWMYGCWMNKELAKEDPQSSLIYATYRGADRVRLQDEVSIDAEEIGFKNLGSVKPKENCEWTCSIHLSDSDGVLLPPSTTGNYLRVAYFIQVHVSVPRASDLIVTVPVSHVLPSRNSEWLEWRPEKWMENCQMLQRHDKLAVSRSILESPVYEGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMN7</accession>
    <name>A0A8B7YMN7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110980939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093715.1">
        <property type="nucleotide sequence ID" value="XM_022238023.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093716.1">
        <property type="nucleotide sequence ID" value="XM_022238024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMN7"/>
    <dbReference type="GeneID" id="110980939"/>
    <dbReference type="KEGG" id="aplc:110980939"/>
    <dbReference type="CTD" id="6878"/>
    <dbReference type="OMA" id="MPEETCQ"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000030">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000001">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="11"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="467"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022093715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022093716.1"/>
        </source>
    </evidence>
    <sequence length="670" mass="71937" checksum="811408A229F04183" modified="2022-01-19" version="1">MAAKSLKKPKASLAQESVKVIAESIGVSHLPDEAALALAEDVTFRLKNLIQESAKFARQSKRRKMSTSDFDDALKVENVEPLYGFNTPEFIPFRFASGGGRELHFIEEKEVELSEIISTPLPKVPLEVSLKAHWLSIEGIQPAIPENPPPVGRDLQKSDATETLVPKKPSFKDQAGGKSGEEGGKLAPPGLKGKGALVAESVKLKPVVTHELSVEQQLYYKEITEACVGSSETRRAEALNSLTSDPGLYQMLPRFSTFISEGVKVNVVQSNLVLLIYLMRMVKALMDNSTLYLEKYLHELVPAVMTCIVSKQLCLRPDVENHWALRDFASRLMSSICKKFSTTTNNLQLRISKTFDHCLCDEKSTMAAVYGALSGLCELGTEILKSMVLCKLTSISDRVRLSSESPIISSVDKSAIDHLMQLVLKHCAPYLKQTRPTPDDLDAYKSEFGFLGTALYTQVIKLRTQPASSGTQTSSSQARPTLNLSQGRSVSFSGLGPRTPTTPVTPLGGPPRTPTIITRPSFQRLASAPAGPSSTAGSGQQKIVLVTTSSSRSSSLVSTIQASTTIASPPSAPTIVRVIGGQKPATSNYGSAPPITSTQKFVVVAPTSAHQQPPVKVKVEAPSGEAESPVPAVGGSDSTKLMSLVHAASMQSPLSTEADVKSEPGSNENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMQ9</accession>
    <name>A0A8B7YMQ9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110981343</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer and homodimer. Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022094549.1">
        <property type="nucleotide sequence ID" value="XM_022238857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMQ9"/>
    <dbReference type="GeneID" id="110981343"/>
    <dbReference type="KEGG" id="aplc:110981343"/>
    <dbReference type="CTD" id="102157402"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022094549.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20730" checksum="313A519C804E29B6" modified="2022-01-19" version="1">MATGNAEERNNANILLTGTPGTGKTTLGQELADRLSMTYVNVGDVAKEKELYEGWDDEYECPFLDEERVIDELDDVLRQGNCIVDYHSCEFFPERWFDFVFVLRTDNTNLYNRLEQRGYTGKKLEDNVQCEIFQTILEEAVSSYLPSIVFELQSNTPSDLESNLSTIEEMVKRWRSNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMR9</accession>
    <name>A0A8B7YMR9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Deoxynucleoside kinase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094559.1">
        <property type="nucleotide sequence ID" value="XM_022238867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMR9"/>
    <dbReference type="GeneID" id="110981354"/>
    <dbReference type="KEGG" id="aplc:110981354"/>
    <dbReference type="OMA" id="MIERSIY"/>
    <dbReference type="OrthoDB" id="567086at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019136">
        <property type="term" value="F:deoxynucleoside kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01673">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001571">
        <property type="entry name" value="Deoxynucleoside kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050566">
        <property type="entry name" value="Deoxyribonucleoside_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031314">
        <property type="entry name" value="DNK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513">
        <property type="entry name" value="DEOXYNUCLEOSIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10513:SF24">
        <property type="entry name" value="THYMIDINE KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01712">
        <property type="entry name" value="dNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Deoxynucleoside kinase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022094559.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="33472" checksum="CA2D33385374789A" modified="2022-01-19" version="1">MSNENQENSGEEELHSPITNMLLTRQNRFERLDLNRVNSRVSSQHRAPLGDITSVSNVISENNSTYGPKTDKPRTIVIEGNIGSGKSTLLKYFDQKKGIEVFPEPVRKWQDVRGTNMLDLLYQDPSRWSFAFQSYVQFTMLQVHQAPTSRRVKMMERSLHSCKYCFIENLYQTRRLQRPEYNVLSEWFDWLQTTKDLHIDHIVYLRSTPEQCEKRIIARSRKEESGIPLDYLRELHQMHEDWLFRRTKFELPAPVLVLDATKPLDDMVEQFTLLEEKLHLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN46</accession>
    <name>A0A8B7YN46_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="21">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC110981126</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
            <location evidence="4">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="21"/>
    <dbReference type="RefSeq" id="XP_022094087.1">
        <property type="nucleotide sequence ID" value="XM_022238395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN46"/>
    <dbReference type="GeneID" id="110981126"/>
    <dbReference type="KEGG" id="aplc:110981126"/>
    <dbReference type="CTD" id="5347"/>
    <dbReference type="OMA" id="IQIHKSM"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000727">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000003">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000284">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF93">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="29"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="24">
        <location>
            <begin position="411"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="24">
        <location>
            <begin position="510"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022094087.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="70539" checksum="4040817B4F62C662" modified="2022-01-19" version="1">MSARPREDLRVKDACIPDFVVDPRSGKKYKKGRFLGKGGFAKCYELIDVATNTTYAGKIVSKNLLVKPHQKEKMSMEIAIHRSVSHKHIVGFHGFFEDTDNVYILLELCRRRSLMELHKRRRAITEPETRYFMRHAVLAMQYLHKNQIIHRDLKLGNLFLDDEMDLKLGDFGLATRIEKEGERKRTLCGTPNYIAPEVLAKKGHSYEVDIWSLGCIMFTLLVGKPPFETSCLKDTYLRIKRNEYSIPSSCKVSPAARSLISRLLKNNPHERPSVDSLLEDTFFTSDYLPPKLPTTCLTVTPRFAPLVTRKPLKEINAKDENASPTKAGMDLLHKGTLPKPFQGQSENQASGRDQAVSIPTARVQSAKTEEECSYLTDLLSQLVSVVHCKPAEVVDMRMDDAEDPAAAPVLWISKWVDYSDKYGLGYQLSDGSFGVLFNDSTKLLLQSNGEDMEYIERDGTEKFFSIDSFSESMRKKVTLLKYFRNYMSEHLLKTGAAVKLESDNLARLPFLRTWFRTRSAIVLHLNNGTLQINFFQDHTKIILCPLMAAVTYIDETRQFRTYRLSLIEKCGCCRELASRLQYARIMTERLLAPKTHSAKPHKETTSAVNTKEGALQTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNP9</accession>
    <name>A0A8B7YNP9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Large neutral amino acids transporter small subunit 1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110981221</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094292.1">
        <property type="nucleotide sequence ID" value="XM_022238600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNP9"/>
    <dbReference type="GeneID" id="110981221"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022094292.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="54162" checksum="19C0DEBA17CF5512" modified="2022-01-19" version="1">MEPTGLDPTASSENHSVKGSDKMSLYSNSGSSSVVSDVKLLRKVSLLNAVTVIVGSIVGSGIFISPVGVLANSGSAGSSVLIWAACGAISLVGALCYAELGTTLSESGGDFTYIRTAFGSLPGFLYLWVTMMVAFPSQQAIIALTFANYVSLPFYPEPECPPSIELRSLLAAVCLVTLTIINGFSVRMATRVQDVFTLGKMLALILIIVMGIIELTKGTTTSFQNSFDTVPGLEVSASGIAQAIYAGLFAYGGWSNLNFLTEELQNPNRNMPLAIIIAVPVVTTVYVLANISYLAAMSPQELLISPAVALTFGEKVLGAAAVIMPVSVALSTFGAVNGMLMASSRLSFVGARSESLPQVLGMIHVGQETPLAALAFMCFMSLMYLFAADIGQLLNYFNFVFWTGVGVSITGMLFLRWRRPDLERPLKVPWILPVIFVLVCIFLVVFGTIGQPMDTLIGLCISLTGVPVYFFGVYWTSKPKWLLGLIDAATVAIQRTLLLAPEHTSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YP65</accession>
    <name>A0A8B7YP65_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin-9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110981191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094240.1">
        <property type="nucleotide sequence ID" value="XM_022238548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YP65"/>
    <dbReference type="GeneID" id="110981191"/>
    <dbReference type="KEGG" id="aplc:110981191"/>
    <dbReference type="OMA" id="CDSIRRH"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022094240.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="30604" checksum="2FF70BA2F5B8BE32" modified="2022-01-19" version="1">MPVCDSIRRHLAIKSNLARGILAEMAGTFILVLFVDGGLAQAAVSGYTSGTRVSTALTSGMGVAFGIYTGVGVSGGHVNPSITVGLASVGKFAWRRAPLWIAAQFIGAFVAAYVVYGIYYPGLDHFDNGNRTVFGPTGTGGIFCTYPQPYFGLWVGLAEQIINTGLLLHCTLMFFDERNGKPTKGMEPFFVGLSVAVIILAWGHNAGAPMNPARDLAGRLLSWQVGYGADVWQPHGMHWWWVPTFVPLLGGLCGANFYFLFVEMHHPKNVGESSANEGTPLEETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQA5</accession>
    <name>A0A8B7YQA5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat, PH and SEC7 domain containing protein secG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110980880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093611.1">
        <property type="nucleotide sequence ID" value="XM_022237919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQA5"/>
    <dbReference type="GeneID" id="110980880"/>
    <dbReference type="KEGG" id="aplc:110980880"/>
    <dbReference type="OMA" id="MHSARNL"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093611.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15537" checksum="332DA32E5E3D5EC6" modified="2022-01-19" version="1">MLSKNVKLDLHEAAFSGNVGLLRLLLDQGEDPDGRSLHGQTALHRASMNGNLDCARILISYGAQTHMQDQAGCTPLHYAAGNGHLVLVKWFIHEVDVNLTPKSNKERTPRMLAKRNGHSKVAHFLAEMENKQSGFSWLGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRN2</accession>
    <name>A0A8B7YRN2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U3 small nucleolar ribonucleoprotein protein IMP4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095938.1">
        <property type="nucleotide sequence ID" value="XM_022240246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRN2"/>
    <dbReference type="GeneID" id="110982092"/>
    <dbReference type="KEGG" id="aplc:110982092"/>
    <dbReference type="CTD" id="92856"/>
    <dbReference type="OMA" id="IGTMSEQ"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="82"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022095938.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="34090" checksum="C2842EEE8F3BB140" modified="2022-01-19" version="1">MLRRQARQRREYLYRKSLESKDRIISERKRKLKEALDENKPIPTELRKDALSLQKALAYDDEGGQEYSHIDDEYRWAGVEDPKIMLTTSRDPSSKLKQFAKEVKLIFPNAQRLNRGNYDVSQLVQACRANEVTDLLIIHEHRGVPDALQVCHLPYGPTAFFTLLNTVMRHDIPNIGTMSEVYPHLIFHNFKSKLGERVMNILKYLFPVPKEDSKRVITFANQDDVISFRHHVYKKTDHRNIELSEVGPRFEMKLYEIRLGTIEKEDPGDTEWVSRPYMNTAKKRRHLADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YS16</accession>
    <name>A0A8B7YS16_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110982151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096074.1">
        <property type="nucleotide sequence ID" value="XM_022240382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YS16"/>
    <dbReference type="GeneID" id="110982151"/>
    <dbReference type="KEGG" id="aplc:110982151"/>
    <dbReference type="OrthoDB" id="10664397at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096074.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14347" checksum="0D4FCA77AC5ADB01" modified="2022-01-19" version="1">MPVPLVDRLEETGSAREQTKRTSPSSLKGIVVPDEVLLMTCIPGSQLPLTPSSATRHTPCSRSSANTAAWVWSICFHASEWAVPCQSKSRSVTSISYSLPCPMPSSVVVFGSQISSSQNQTWTSSKAGTWTCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YS91</accession>
    <name>A0A8B7YS91_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Motile sperm domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110981766</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to-mesenchymal transition (EMT). However, another study suggests that it is not required for EMT or stem cell self-renewal and acts during later stages of differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095335.1">
        <property type="nucleotide sequence ID" value="XM_022239643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YS91"/>
    <dbReference type="GeneID" id="110981766"/>
    <dbReference type="KEGG" id="aplc:110981766"/>
    <dbReference type="OMA" id="VYNPYEF"/>
    <dbReference type="OrthoDB" id="10022288at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000431">
        <property type="entry name" value="motile sperm domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039283">
        <property type="entry name" value="MOSPD1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34441:SF1">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34441">
        <property type="entry name" value="MOTILE SPERM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="12">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022095335.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23352" checksum="6161EB0B30A1BB2D" modified="2022-01-19" version="1">MQLDRRPRLVDGKLPVFVFPTELVYYADDRSSHKQVLTVYNPYDFTLKFKVLCTTRRKYAVVDSEGTVRPGCCVDVVIRHKEIKESSYGVRDKFRLNIYEHGRRDAIGSKDIPTILLPTSQGREKESDELSSTPGEGSTNMPFTAVARQRQVTPGPTVVLLALVCVVALLLPMQGEAGSSLPLYLHLTVNQKLIAAYVLGLVTMVILRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSW1</accession>
    <name>A0A8B7YSW1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SH3 domain-containing YSC84-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110982352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096383.1">
        <property type="nucleotide sequence ID" value="XM_022240691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSW1"/>
    <dbReference type="GeneID" id="110982352"/>
    <dbReference type="KEGG" id="aplc:110982352"/>
    <dbReference type="OMA" id="CICTYSI"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="116"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022096383.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19945" checksum="F6184C3D2D79793D" modified="2022-01-19" version="1">MCICTYSIYYALVTTLSSLWVPAVWSLQKIVYLPVLLHLLLVPVLVVSLAYHVCWFEMSSNDGKKTRSFRSLSFRSSKNKKKKSSSDTVDGSTAPQHYRHSVSEFTNNNNFTSKSTPVCTVIATHSFTAILPCDLSFNQGDRIDVLTRTNTCFDWWEGRMNGRIGIFPANYVKVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTV2</accession>
    <name>A0A8B7YTV2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110981482</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110981482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094776.1">
        <property type="nucleotide sequence ID" value="XM_022239084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTV2"/>
    <dbReference type="GeneID" id="110981482"/>
    <dbReference type="KEGG" id="aplc:110981482"/>
    <dbReference type="OMA" id="PRRISCH"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022094776.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="34333" checksum="5F49483D64D44C87" modified="2022-01-19" version="1">MADDIQRVFLWGISRSMSTALLKCLSYAEGIQIINQPYASAFYTGPQAERPELNQNDKLLNKIVATYDKLSEDSEKAKVRGLAPSLMSLERIRDDLLQAQYSDKKVLLCRDQAHYLKGRYDMLPRGFKYSFLIRHPYKVARSLKKLLLGIFGDFPNMRELPLLAFPPGCGFKDLFDLVEYVRENIDPHPTILDTDDLLQDPARILSTYCSRMGIPYSSKMLSWETGNEITKTWIMCKEIVLCNESQEFYKRAFESERFGKPTPIPDPASLPEDVRACAEESMKYYESLYRERITASVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVR1</accession>
    <name>A0A8B7YVR1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110982916</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110982916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097393.1">
        <property type="nucleotide sequence ID" value="XM_022241701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVR1"/>
    <dbReference type="GeneID" id="110982916"/>
    <dbReference type="KEGG" id="aplc:110982916"/>
    <dbReference type="CTD" id="374291"/>
    <dbReference type="OMA" id="GCGGIEM"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="4">
        <location>
            <begin position="104"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022097393.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25783" checksum="B3C7A35EFBA9F296" modified="2022-01-19" version="1">MALHARRVSSLMLRMGRFGPLPTRQLTATSQPVRSLYDQKQPMPQGATNTASNNLSLVPYRQKSSSPVPAPKDSKAEYVVARMDDLINWARRSSLWPMMFGLACCAIEMMHMAAPRYDMDRFGVVFRASPRQADVMIVAGTLTNKMAPALRKVYDQMPEPRWVISMGSCANGGGYYHYSYAVVRGCDRIVPVDIYVPGCPPTAEALLYGVLQLQKKIKRAQNLTMWYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWC0</accession>
    <name>A0A8B7YWC0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110982689</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096981.1">
        <property type="nucleotide sequence ID" value="XM_022241289.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096982.1">
        <property type="nucleotide sequence ID" value="XM_022241290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWC0"/>
    <dbReference type="GeneID" id="110982689"/>
    <dbReference type="KEGG" id="aplc:110982689"/>
    <dbReference type="OMA" id="YYMAGKP"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23963">
        <property type="entry name" value="GT29_ST8SIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF36">
        <property type="entry name" value="SIA-ALPHA-2,3-GAL-BETA-1,4-GLCNAC-R:ALPHA 2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022096981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022096982.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54676" checksum="8B976C236FE349E5" modified="2022-01-19" version="1">MAAVTSPFRVWKLGGSTIRPSLRFDGTGSKVLAHPRPSCGRNLPCWLGHRIWLTCRRHLLHSRVFLLAAVVVGMTLLLRSSASGVVQADELMVEEGREKAALRTTRVSKKNPPLGNETIIVIPARANNSRSDLAVHKDAEPPAPSPSPLQLQTPTDPRPPKVAPHDRNSPNFTKEMRHFAESYAHSYPDGDQFMAYVKTVIKRKWEPSLNNTNQFRRDIRAALAEVGKSKNVYLTKHNTPRHKVMMYYMAGKPAKIADRIWETLPNDSVFQADRFKVCSVVGSSGILKGSKCGEEIDRADFVFRFNLAPVRGFETDVGEKTNFTTLNPTFIMYKMNSIKNTSDVAKFTEALRQFQNSFLYLPGFAVSGSLRLLVKAAGVASDARVTKPVYGSPDHFLVVSNLWRKTHNSGLKWPSTGIYGISSLFDTCDRINVFGFWPFAKSSAGRVVPYHYNNNVKATKVHSFDKEFKTLLFLHEKGIINLHLTSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWY7</accession>
    <name>A0A8B7YWY7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Radical S-adenosyl methionine and flavodoxin domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">tRNA wybutosine-synthesizing protein 1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">tRNA-yW-synthesizing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC110982000</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022095801.1">
        <property type="nucleotide sequence ID" value="XM_022240109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWY7"/>
    <dbReference type="GeneID" id="110982000"/>
    <dbReference type="KEGG" id="aplc:110982000"/>
    <dbReference type="OMA" id="TMANIPW"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034781308" description="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1" evidence="21">
        <location>
            <begin position="29"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="153"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="23">
        <location>
            <begin position="462"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="98"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="331"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022095801.1"/>
        </source>
    </evidence>
    <sequence length="794" mass="88870" checksum="95C3A429934B33DF" modified="2022-01-19" version="1">MAASISNCNCVVFCTIFLLFCGRNNVFADENRSEDDTLSSSQISWGSKLVTKLWTSAPCWYGVTFVTGVATLLLVIIWWNRNENEDQNVHVHMPDAAPARRPAEGRHQSPRPAMGGISQSRKKPVATGAAAANQNGDVTGRHQGLTSSPKHRLRILYGTQTGTAKHFAEDLAKQVASTGNAAEVVDLKTFDPESHILPETDGLVTCVLIVATYSEGKPTESAAWFCRWLEEATTDFRVHKSLLRGLKYAVFGLGNSLYEGHYNQVARDVDRWLSTLSASAIVARGEGDQNVAESKHGGIEADFEAWKTLLLQTLASNASICCSTEKQTCECGKTEGGCRQATEKESRNADKEEMYDSSSEDDNCDDDFIDDGSGDAKSKITQTNGLTDLEDLGKVMKKMKKAKESKASDKASEPREMITPMLRQALSKQGYRLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDEPEAILKDALKNHYQLIKQFKGVPGVKPERMAEAMNVQHCALSLVGEPIMYPEINRFAKLLHSHKISTFLVTNAQFPDAIRSMVPVTQLYVSVDASTKESLKKIDRPLFRDFWPRFLSSLEALSEKGQRTVYRLTIVNGWNNEEIEAYANLVSIGKPDFIEVKGVTYCGESKASTLTMKNIPWHEEVVGFVQKLVDLLPDYAIASEHEHSNCVLAAHKKFKKDDEWWTWINYSRFHELIAEYEASDGERRFTAADYMSKTPAWAVFGCKEQGFDPSETRFRRKGKNKDISGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YX00</accession>
    <name>A0A8B7YX00_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PHD finger protein 24-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110982825</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097217.1">
        <property type="nucleotide sequence ID" value="XM_022241525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YX00"/>
    <dbReference type="GeneID" id="110982825"/>
    <dbReference type="KEGG" id="aplc:110982825"/>
    <dbReference type="CTD" id="23349"/>
    <dbReference type="OMA" id="MFELMEI"/>
    <dbReference type="OrthoDB" id="9978298at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031946">
        <property type="entry name" value="KIAA1045_Zf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF85">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16744">
        <property type="entry name" value="zf-RING_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022097217.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="54681" checksum="2CE9A0AFFCF200E3" modified="2022-01-19" version="1">MGVTLGKGKQDEKKAPIDNFRRAAKVVTIMRKTSRDASTRLADDRLQEPHSAPAIETVAEETELVRKESQALLEDLRNMSSKKETGSRQQKVVDDSRTLVFKDTTDAWAALREGFVDETTELPDTEFSLVESAISGYRTVERVRGTNEDDPSRGGEQEQQRGRSQSNQSDLNIPYTLPAESDQLSNDEKCAICRSHSGGILFPCRICTHVFHESCLQKSGRVQDSTARQLLRRANAGVGWSCHECEDLSKLLHQDDMFELMEVFETADIDSDASISLEEFMAFRRRVFKDRHDRDMLSHEEEDEINQFKAIDTDRTGSLSWWEFLSHEAVRRLSSQSKKSLAKKLSPKEVQTARENFRAFDTDGDGVITEFEARRAYRSWYSNFIPDPNEMTLRESDSETNHTNEENSKRRKIPEDIWLARSKELNTHVDANTNLLMSGDTDGSGTISWEEYLLEQALFIIAARPNVGPVKLNRRPSFAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXV3</accession>
    <name>A0A8B7YXV3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitogen-activated protein kinase kinase kinase 7</fullName>
            <ecNumber evidence="5">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="primary">LOC110983312</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022098169.1">
        <property type="nucleotide sequence ID" value="XM_022242477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXV3"/>
    <dbReference type="GeneID" id="110983312"/>
    <dbReference type="KEGG" id="aplc:110983312"/>
    <dbReference type="CTD" id="6885"/>
    <dbReference type="OrthoDB" id="10261027at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14058">
        <property type="entry name" value="STKc_TAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000143">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000152">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46716:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="17 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="27" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="16" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="21" id="KW-0346">Stress response</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="20" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="19"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="335"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="437"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="604"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_022098169.1"/>
        </source>
    </evidence>
    <sequence length="682" mass="76617" checksum="4C2B9711334866BF" modified="2022-01-19" version="1">MAKLQHQVSFAEEIDFHELEFEKVVGKGSFGVVSKAKWRGKYVAVKMIESEEEIKAFRVEVLQLSRVCHPNIVTLYGACTHNPVCLVMEYAEGGSLYNILHGGPPQAIYTAANAMSWALQCAKGVAYLHSMKPRALIHRDLKPANLLLMAGGTVLKICDFGTACDIQTYMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVISRRKPFDEIGGPAFRIMWAVHQGTRPPMIRSIPKPLEKLMTRCWAKEPRRRPSMEEVVGVMSNLIKYFRGYDQPLRYETTDTEANKPSFGAVEGELRTQDSTYSTNQTTSTATNNTTIHNTVISAAENSGTQQQQEAQRPSTVTTQLLRPEVPGRRRSPDYELKRRSADILAYTGSKDADEGGETATPKPANHGFVWPLYKTLPETTTVHTHRRSNSHGKIEAFTDIPTQLPDTIQPKPTSPMTVTQPVSPTITISSAPRPVPPQRPHSSHLPHSVTAPSHLSAFDPYKQRSNSDDGTYLSSEDQLSLARLNSNSLSTSVLSQIGIDTGVTSQTRPGDRPLRSISLEQKHSGTFEEETVIPMAYMTLDHHLQPLLPNPNSSESQEIFDKHRQAAQELVRVQTEVALLHQRKKELANELDQDWKDQQASFRMVEEHNELLKEKESLLEVHKNLRAQLDIIRAQVQRKQKMHNTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1X7</accession>
    <name>A0A8B7Z1X7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110984100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022099613.1">
        <property type="nucleotide sequence ID" value="XM_022243921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1X7"/>
    <dbReference type="GeneID" id="110984100"/>
    <dbReference type="KEGG" id="aplc:110984100"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF33">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022099613.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="49979" checksum="34493450DFFA8FE4" modified="2022-01-19" version="1">MNAQDAGSAIGDFVREAASAYQLSSAALSTRTLRRYLAWFIFGIAATVVFCLGILQGASSGWNLQHAEVVGRHGPLRGGPWHAAGTHHQRRETRTKLEPQSVHIRNKSMSNLPILDALSFQRLESVVKNWGRTEPNLTSVQITRSIRNHTIHSICQAEQLNDISMLDAAAREALTHQIIVDDERRFLYCYVPKVACSNWKRVIKFMQGTLGDIGAKIKMDHKNGLVFLDSFSKKEIQYRLRNYFKFMFVRNPVERLLSAFRNKFGEEALSQYKQRYAPRIIHRYRGSWDGKDTNITLEEFIRYLLDTRTTKMDQHWKPMHLLCQPCAVQYDFVGSFEQLSEDANYVLGKIKGDTGAYFPPRQGWYNPTTQEKVEALIGAVNPIYIQQYVDKYILDFITFGYAPPKQYYLKYHRNDEGKETTSEDDIDPRVSEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2G6</accession>
    <name>A0A8B7Z2G6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Exosome complex component RRP4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exosome component 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110983859</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of the RNA exosome core complex (Exo-9), composed of EXOSC1, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8 and EXOSC9; within the complex interacts with EXOSC4 and EXOSC7. The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with GTPBP1. Interacts with ZFP36L1 (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099167.1">
        <property type="nucleotide sequence ID" value="XM_022243475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2G6"/>
    <dbReference type="GeneID" id="110983859"/>
    <dbReference type="KEGG" id="aplc:110983859"/>
    <dbReference type="CTD" id="23404"/>
    <dbReference type="OMA" id="GPYIPEV"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05789">
        <property type="entry name" value="S1_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000022">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000038">
        <property type="entry name" value="Exosome complex component RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025721">
        <property type="entry name" value="Exosome_cplx_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048565">
        <property type="entry name" value="S1_RRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14382">
        <property type="entry name" value="ECR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21266">
        <property type="entry name" value="S1_RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exosome complex component N-terminal" evidence="14">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="RRP4 S1" evidence="16">
        <location>
            <begin position="72"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="15">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022099167.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32508" checksum="90029A967742A3E2" modified="2022-01-19" version="1">MATYIRSARKRKCGKNFPEPKRLVTPGDVITSDTDFMRGHGTYMEEDKLHASVAGVVETVNKLICVKPLKTRYNGEVGDVVIGRITEVGQKKWRVDTNSRLNSVLMLSAVNLPGGELRRRSAEDELMMREYLAEGDLISAEVQQVYSDGALSLHTRSLKYGKLCQGILVTVSPSLVKRRKTHFHNLTCGASIILGNNGYIWISPIAGVEEEEGGGFVQNLEPVLLSDREVISRLRNCIVGLAEHRMMLYDTSILYTYEASLKYTLEELLKPEVMEEVVEDTRQRLEQET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2H8</accession>
    <name>A0A8B7Z2H8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase PDZRN3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110983030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097586.1">
        <property type="nucleotide sequence ID" value="XM_022241894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2H8"/>
    <dbReference type="GeneID" id="110983030"/>
    <dbReference type="KEGG" id="aplc:110983030"/>
    <dbReference type="OMA" id="VWSETEH"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06716">
        <property type="entry name" value="PDZ2-PDZRN4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16512">
        <property type="entry name" value="RING-HC_LNX3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000214">
        <property type="entry name" value="E3 ubiquitin-protein ligase PDZRN3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051971">
        <property type="entry name" value="E3_ubiquitin-PDZ_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545">
        <property type="entry name" value="PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545:SF8">
        <property type="entry name" value="SLO-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="8">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="243"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="426"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="100"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="552"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="660"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="785"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022097586.1"/>
        </source>
    </evidence>
    <sequence length="1128" mass="126729" checksum="28E84A20A331CD3E" modified="2022-01-19" version="1">MGYDLERFTKPVDEDFKCSICLAVLENPLATPCGHVFCGNCVLPWVVQHGSCPLKCDKFSTKELNSVLPLRNLIMKLEIRCDNHTRGCQEVVKIQMLPQHLEDCDFAPVTCTNKGCEAVVSIKDLVQHQTQQCEYRAVGRCELGCNLVLQHNAVADHCCLKAMQAHCANLQAKISSQEHGLKKTTVRFGKREKSLLAQIACLQNEIQMQALRYQKKLNECKAEVEYMSAMAVYDRPCEEVPLALQLGRENGSLGFNIIGGNRVDGISEGIIVSRVIEQGPADKSELRLHDRITKVNGVDLSKATHEEAVEAFKNATEPIIVQVLRRAPRSKVPGDKEGTTALCNVGTQTELQSEDLLWKVLQRCPSPLETKNGDLDMDGLCEISPQEQMTVIDDDLMNDLDAMDNVDIPILDEDGMDKAYELEYEDVTLRRTSDGAKLGLTLCYGTEEDTGIFIKEVDPNSIAGEDGRIKEGDQILQINGEDVHSNDQALSLFAQQSDSTSLLLCRSQLQFDECLFDEHNALLEDIQLDMLEQTHQEAMQFTSCLLAEHDSRQLDDDSKTDTTGTTETTSLHHEKDSGVGRATDESVRNDESSGQENMPDDCSSTHRKYAPQQANRLGNRDLRYSNDSFISNGATEADFPTHEISLEDCMKFQAALESKCDKHMRSDTDESTRGKESKVMRLGSDSMETTSLSGDSLSRTSRNRSGASDQDEATQHRDDSKSSIWVAQQNGQKNLEPNGQPRVSPEEPEDQRFELESRKLEMIVENGQVGSPTHRPTELVLDGLRNSDNSLHRMSPSEKETKTMTSSSSGSTRQHRAPRTVPGSPGRSKSSSGSRDRSKSSSSSGSGKEKSSPVKTATDKDSGAGAPPYPSKPYRRRPATNPHLRAQQFVQRNPYFLQQEEAAAHLIRQNWKLQQQNRQLKKSLESLGPAQKLQSCPSIMSIPSHAKHYRSYLHLVNQNEENTLGTSQPSKKIINHNEWKVKIRSDGTRYITKKNTRGKILKDRANKIQEERGGLTTDDEAMSEMKLGRYWSKEDRKRHLERARDQRLRREYMVQSRMECLQEQMEEEGRKELNIVELSQRKMLKKKSGRKMMLDDFTTIQEMLVHGTRVSPETAKAFYNPLLNVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2U7</accession>
    <name>A0A8B7Z2U7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">RING finger protein 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11" type="primary">LOC110983079</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097695.1">
        <property type="nucleotide sequence ID" value="XM_022242003.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097696.1">
        <property type="nucleotide sequence ID" value="XM_022242004.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097697.1">
        <property type="nucleotide sequence ID" value="XM_022242005.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097698.1">
        <property type="nucleotide sequence ID" value="XM_022242006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2U7"/>
    <dbReference type="GeneID" id="110983079"/>
    <dbReference type="KEGG" id="aplc:110983079"/>
    <dbReference type="OMA" id="CYLFRAL"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16469">
        <property type="entry name" value="RING-H2_RNF24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022097695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022097696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022097697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097698.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16009" checksum="5E0DAA0B55F1DCF2" modified="2022-01-19" version="1">MSISMVAHMPNATMSDNLPLNFEQVLPFLVVAGLILLLNLVFCCYLLRLKRSGRVDTGFKTVSYTKKKIGAKFDTCSVCLEEFEEGTKIGQCACQHVFHVVCISKWLRLRNTCPICNAILRADVTERTSLRVNATPPQPASSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z365</accession>
    <name>A0A8B7Z365_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">Adenylosuccinate synthetase</fullName>
            <shortName evidence="9">AMPSase</shortName>
            <shortName evidence="9">AdSS</shortName>
            <ecNumber evidence="9 11">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983967</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9 11">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="9 11"/>
    <dbReference type="RefSeq" id="XP_022099407.1">
        <property type="nucleotide sequence ID" value="XM_022243715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z365"/>
    <dbReference type="GeneID" id="110983967"/>
    <dbReference type="KEGG" id="aplc:110983967"/>
    <dbReference type="OMA" id="GVPFKWI"/>
    <dbReference type="OrthoDB" id="10265645at2759"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="48"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="74"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="334"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="366"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="448"/>
            <end position="450"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022099407.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="51167" checksum="1447A796DF80EB78" modified="2022-01-19" version="1">MAAEPVIVNHERDMKNVDNSTDNRSLNLKKMRTDPQNKVTVILGGQWGDEGKGKLVDLLSTDADVVCRCGGGNNAGHTVVVDGTEYDFHLLPSGIINPNCKSVIGNGLVVHLPGLFEEGAKATKKGLNGWTKRLLVSDRAHLVFDFHQSVDGLQEKEKGKKSIGTTKKGIGPTYSSKASRSGLRICDLMADFSAFSEKFRHLVNVYQRMFPDLEVDIKTELERYEEFAEKLRPMVGDTVYFMYKVLQDPMKKIIVEGANATMLDIDFGTYPYVTSSNCSIGGVCTGLGIPAKNIGDVYGVVKAYTTRVGDGAFPTELNDEIGSLLQERGHEFGVTTKRRRRCGWLDAVLLRYTNMINGFTAFAMTKLDILDVLDEIKIGVAYKYKGEELPCFPAHQDILKEVKVEYITMPGWKSNTEQIRTFEDLPVNAQAYVMKLEELVGVPVKWVGVGKSRESIIRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3Z7</accession>
    <name>A0A8B7Z3Z7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty acid amide hydrolase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110983262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098076.1">
        <property type="nucleotide sequence ID" value="XM_022242384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3Z7"/>
    <dbReference type="GeneID" id="110983262"/>
    <dbReference type="KEGG" id="aplc:110983262"/>
    <dbReference type="OMA" id="PGWHIDG"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="174"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022098076.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="68656" checksum="1586B2EA1DAAFB1E" modified="2022-01-19" version="1">MEQPGQLQSIFAGLVCGVGFTLLLLFWRTERSAGRRKFKKRKLGKADEPVTYNLRAGQGGPALRGKIAKLGLWLVNSYFGRVSGLKDYLMKQGNVFFFRDILMEDPPTVYPLIAWERQREDGSGGGNGGRVDLEPLLVSENKRQESDFRFREIKDYYDGYRSGKLTPSKVAENIIAAITRSENMEPKLRAFIEYNTDEIRKAARESTERFSNKQPLSVLDGIPIGVKDEIRVAGHHLRQGSTFMGQSVSEEDAVVISRLRASGAVIVGVTNMQENGMGTTGINISKYHGTPRNPYNVNHFTGGSSSGSAAAVAAGLCPVAMGTDGGGSVRIPSAFCGVVGFKPTFGRVTWQGSPITFTTVAAQGPLCTSVRDAAIMYAVISGISPCDKYPMVPPPMDLDGFNESDLKGLRLGIDKAYFKHADPEIVICCEKAVRFLESRGAEVVSIQIPELEEARTAHLLTILSEMRFNQQESFWNQLDEQYFENAALMSMIESMTITDFLQAQQQKTRTITFLKEIFKQADVILTPGCAVLAPKINPVYLKEGFTDTKLTTDIMRYAFLANFTGLPALVVPVGYSMQGLPIALQIQGAWWQESKVLRVGRVAEEFLEHVRKPQAHFQILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z405</accession>
    <name>A0A8B7Z405_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Tyrosine-protein phosphatase non-receptor type 13-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC110984132</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099692.1">
        <property type="nucleotide sequence ID" value="XM_022244000.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099790.1">
        <property type="nucleotide sequence ID" value="XM_022244098.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110984132"/>
    <dbReference type="KEGG" id="aplc:110984132"/>
    <dbReference type="OrthoDB" id="165498at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17101">
        <property type="entry name" value="FERM_F1_PTPN13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06694">
        <property type="entry name" value="PDZ1_PTPN13_FRMPD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06792">
        <property type="entry name" value="PDZ2-PTPN13_FRMPD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06695">
        <property type="entry name" value="PDZ3_PTPN13_FRMPD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06696">
        <property type="entry name" value="PDZ4_PTPN13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23060">
        <property type="entry name" value="PDZ5_DrPTPN13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14538">
        <property type="entry name" value="PTPc-N20_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
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    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
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    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011019">
        <property type="entry name" value="KIND_dom"/>
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    <dbReference type="InterPro" id="IPR052074">
        <property type="entry name" value="NonRcpt_TyrProt_Phosphatase"/>
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    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
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    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46900:SF2">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
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    </dbReference>
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        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022099692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022099790.1"/>
        </source>
    </evidence>
    <sequence length="3465" mass="378419" checksum="DE65FC605B22442D" modified="2022-01-19" version="1">MPVSSLVPEGTVKVSVSDVLEVRGGPLNEEELWSVLCQSAKALQDVFLKGEAVVQGTPRFVLCPYTLHFTPSGRVTFAETIDPTLPNIRDFLSPEVLTGHLNPSDVAVEKMLVYSLGMTLFWASEYSTPAGSRPALTRDLHSILRAMTNTNADSRVALIHILEACTLHACQTRMGLPYAHHVMKLSRIVMGSVYELDKLVHPYSPGDEVDADLNSSNPLNGSGSFVQNGGPLEHNRNSDSFFALPYLTHQDVQPFYQNLPPPYHFQDFRPCACSSLAYSPWRLSPSKRPNYHHNFNNNATSNKRPRSAKDSRHYLHELPDSSHHSRAHSTHRPSNISTSTMDSRESDEEAGGMRDSLLPHHRTHRTTGVDETGRSYHLSDIPTLSSGDRSRERSRDGSRGRSLSRSREGSRGRSGERSRERSADRFSRKSHSPSSQANAVYDRLYERRERLRLLREQLGIRHRDLDIRRPLLGYHSDGGTMSDDGSEVEGGQEPKVRARSLKSLTSMESAQEGSFYPDQHQYGSSDSLSTERGRSLNRRAQVQGTERSVPDHSSRPLPKATSLRRAESAPRQQMGRVSERVPVNGLASPAGNGTREPPAGKKKLKKFFGPEFVVMSSTANESLDMSPSILCKAGKIPPDRKKVTVVLLNGRRLDLMCDLGTKGQEMFDIVTSHMGLSEKVYFGLAYIRDGEYFFLDSDEKLFKVGPESWKEEVKKGSKKVIATDKFTLFFRIKFYLENTALLKDQLTRHQYYLQLRRDILEERTRCDERAALQLASLALQAEMGDYQPETMGRNYFLPEHYVPSGIIDTLGVPRIRQNLPPMHGAHSSMGELQAEMEFLMEARKLQEYGIHFHRASRSKKDPSASIWLGICTRGVIVYEKRGSVRQQIHAHPWHLTKKIAFNRKKFTVEANDGTSSKYIHYTENYKKGRYMLQLCQSQHKFQMAMRLKANTSRKFGQDFPVEAESFTDSLRFSAYNDYQEGLDFSDDDENGSIQNSIPESLFLQGQEDVSGPSTYPGNSGGQNGQRHVSDYEEIAMGKRSRSSPSPDRRWERDPPVYQNLPAYPSQSKDWEEGRGEGRGREGSPSRAVLPDGRRNEKNRRHRARDYHSKETLPYDELNVERSASKASQGRRSSRLERQNQHLSFHSGSSNDTQGENGLPSSLRSPNGAQMAHRARARTPDPKALTPESDRPSYEDEHPYATVADMKIQGEHHSLDDEDGREILGLDEVDVPHVIDASIRTHERTRPDTLDNHTEVISETLQERLNDLSPPEQPERDITIITLKKDPKQGLGVTIVGGENSRSLDLGVFIQSVIPGGPADRDGRLHPGDRIISINGQSLEGIGHRVAVDILTNAPATVQLIVSQPRSSSPDSKHRLQVPMDVDEVVMPTQTAQSQAQLQLPPSSNGQPDTPRTQKRKHTPPQKPQRRPQSFGSNYSLALSDASHASEGSVSSKTTPKAGRANMVMMAESARPPVPPAAEQNTHSGQMKPVAIEGQRSPDKGQRLPSQGKGSPADQSDIHFSSDDEDVPTPRDSDLDDLFPDDHKTLAKPSLLGHGSLSASANSPLSDFFTSPAEALDSAVDNTDATTKTEAEEDHEEGVLDGREELKPGDVYRVQLKKANSSLGISVTGGINTSVKHGGIYIKSMVPGGAADSNRKIQVGDRVLGVNSESLEGVTHRQAVEALRRAPEVSTLVIERGIPPAKASNLPPTPTPSPLVAIGDDGEALIMSGTAREQVQSEPPSSGNAEPDRPTSVTSFTDVERQTPLSRTLDTHSDAPQASPAFSRGESDTTPVLSSAIASPVDEVVKQSVLQAPPPLMSQAPPPLMSQAPPPSASDDEGWVHSTSSRGSTVRRAYVNPPEHEEPKDDVDSIDDGQLPLPSDGLVESRGDTPTIQAFKDYELPDSTPMTDGEDDDQSHSDESESPIPIEHSVMGVGFDPEIASPVLSTREADTLTPTAHLDWRSTPTGALEKGMWGPKSASYRHGATPVIHEQSTDDQHSDQWTDYDNDERSPTPTTEGRSGSPSLDGRSLRDDEFISEEEDEEMMPSPIMHDSRAANDTVISVRSPGLPDIKTATIMTSPSATTPGPYQSQSRGSDTLNSQSPFPSLDGTLPLPSDASGTSRSPTPDLPPLVLPDDSLLRPHDKSPSPTSSITSVGALTLTQTMMSTMGLEGNIELPDLPYVTPENCFEVQLTKGSQGLGFSIQGGKGSHQDPKLCLVRIKKVFAGQKAAASGLVEEGDVILTVNEQPVYDKTHNETVAVLRGAPQDVRLLLCRPSDEELDLLVLQEDEKAFERKLSSPSAPSSPRITKESQTQDEATTPPFTPAPPNATDHQFSPPESPSISLAPSEANSLRLTPVTLAREPELVTKLPLTSPTSSLSSPVKSVSEPLGGEYVEVTLIKPAKGGLGFTVAGGANSGGCYIKDVIQDPAKSDGRLKKGDKLIKVNNQDMLSMSHFDAVSFLRMTPQEVTIKVLRLRERTQEAPTPIPPPVPSSPPPASPTLYSDRPVFPTSEMTQSPSNSSRSDPATAVNLDRLPVVRVQRNPAGQLGLSLTLDLRGAGRSGIVVSDVIPGLPAASEGSIQTGDLIHAINGKNLSGMSLMSARRLLETAPSTVELKLTRNGQPVAPRRRLPTPRSPADSSQEVPRIVLPTSPRSERPLLPPGDGPGELSVEEEMKGVMESLDLDLGDLSSEKMEETDWEDVSESDKDHLDDVDAILASLEAEHNITLPDEIKEKRTLPMDMPGIAVTEVPPARSSRQGSLEVQNGDAKEPEDRSTPSPVYSSPIPTPYLTPTPPATPSLPDMDHEAEAPSPPFSPPAAAVESPFSAGASAAAPHAVPPSEVDSPTPSEAPTVDRASTGIIEKASTIVETDHESEGHAEKSEGGVIWIELEKPANGSLGFSLTGAMKGGKTSIFIKTVTPGGVAEKDGRLRVGDRLLQVNGESLVGMTQNKAVGILRKSKGVVKLAITRQLAKTSSNSTPIQPKRVPVLPVHESPVPSLNLPHRSDEDGEEQGDDGGESLAQSFTESARDAELEADLSEFDISTSLNFDSHSLPLGGVSSMAITPPPPGFRAGYVSGHDTDDDMDNTMDLPDDSAAHPDTGKSSPSASDGQHAAMKFGQALKARGQMVPESDDSSSWGSDTDIPLSGDRGHTPAPRTTPSHKILSVISDAELRRMALARPAPGGHYSGRSLRSVIAGLQKQIDKQDPAEEFKVLRNVKATDNCEEAKKPINKDKNRYRNVLPYDETRVVIQQVGGAKYINASHLDVLVGKDTYRYIACQGPLPQTAGDFWQMVWEQRSDVIAMVTLAMESGKVKCDRYWPDSMETPIMVAGRYQLRLDSMQTLDHFDIRKISMSDTKTNAIHYVTHLNFTTWTDHGVPSSALPLLRYAKYMRKIHANGPVVVHCSAGIGRTGTLITIDIIMALIDRDEPFKIVDIVRDLRTKRQGMIQTKDQYLFCYKAAIELLKTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5F2</accession>
    <name>A0A8B7Z5F2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110984725</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with OLFM4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
            <orientation evidence="1 14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100863.1">
        <property type="nucleotide sequence ID" value="XM_022245171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5F2"/>
    <dbReference type="GeneID" id="110984725"/>
    <dbReference type="KEGG" id="aplc:110984725"/>
    <dbReference type="CTD" id="51079"/>
    <dbReference type="OMA" id="YGIREQH"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022100863.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="18226" checksum="18FF43D7BEC6F9BC" modified="2022-01-19" version="1">MAFNFTSALLGFVNMASTFKQDMPPKGGYPPIDYKRVLPKRGMSGYMMFATCAAVSAIGIFFYGRHNRKRRLWAREEYECFIGITPLLKAEDDRQTLKLLKSNLEQEAIIMKDVPGWKAGESVYESKRWIDPMLLDLYYLHPRKVREKESFGFSTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8K7</accession>
    <name>A0A8B7Z8K7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuromedin-U receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984095</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022099606.1">
        <property type="nucleotide sequence ID" value="XM_022243914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8K7"/>
    <dbReference type="GeneID" id="110984095"/>
    <dbReference type="KEGG" id="aplc:110984095"/>
    <dbReference type="OMA" id="HREHSTR"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="50"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022099606.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44086" checksum="8F15901843B7DBC3" modified="2022-01-19" version="1">MEASYTSELFCDMSFNVSIGEDAASLEYDSLEKTLVTVVMPWILAFGLIGNFGFLFVLWRVTWMRTTLNFFLTNLAIADILLLSVSVLEKIIAYTISPIAVDEYFLGASGCVLLHLVMDVCYFASVSLVTLVTLERYYATCRPHAHREHSTRARPVRLVSIVWFCSFALACPLIPSVCNFTAICLSWPNETRYQDYPNIMGLCLGLDVGAWLGDFADALHTVPFVVAMAVNVVFFSMIIRALNSMVARAQRSGFSDRSQHIRDRVSRMLVINGIIFFLCLAPFQITTMSFLFTPEAKRTDFVWMQVFRILVYINSAVNPIVYNITNPRYRKAFKQAFITRRGPSKLKNYFTNRASSNVEMNARGNTNTRATLNSNVQTSTQQIKTMASSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9R9</accession>
    <name>A0A8B7Z9R9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monocarboxylate transporter 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101712.1">
        <property type="nucleotide sequence ID" value="XM_022246020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9R9"/>
    <dbReference type="GeneID" id="110985180"/>
    <dbReference type="KEGG" id="aplc:110985180"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022101712.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="45359" checksum="C4808EB7C5EFDBE2" modified="2022-01-19" version="1">MACCHLRCWWWRWVVTLAAFNMIFLTLGIQYNYSILYLSLQAEFHSGSAVTGWIGSLSTALSCLCSPLTVLLGRKLSRRAVVSLGVVLFCAGLLTTSFVPAIGYAYLTFGVLCGVGTNLTSHSSIALVLEWFLRKNFSRASVFTVLGSTCGMLVFSPVMTASITRYGWRKALRILSGGILGAGLASSVFLTNPPTEDYAAAPDKSPERKLNLQSMVPMKTDPEGGIKETAGESMDHEANTNEENTEAGGNYIAKPGILVLIKSTEVWLWSVGIVFAFLGWTFFNINFASFMEGLDFNSQQISSCIMIFASGEILGKMSIGVVGDHMPFMHVYWIFTSCVFGTVLLGSLVIAKSYAAVAAVAFGSGVMRAGAYGPTFTACAQVFHKTFGVDTTMVLSIAPSGIGILISAPLSGKNRLSCNIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB97</accession>
    <name>A0A8B7ZB97_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cysteine and tyrosine-rich protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100506.1">
        <property type="nucleotide sequence ID" value="XM_022244814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZB97"/>
    <dbReference type="GeneID" id="110984531"/>
    <dbReference type="KEGG" id="aplc:110984531"/>
    <dbReference type="OMA" id="CCTPEYI"/>
    <dbReference type="OrthoDB" id="10443305at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034697568" evidence="3">
        <location>
            <begin position="31"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100506.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19294" checksum="DD8DAABB1A7C637F" modified="2022-01-19" version="1">MDSRLSLAESLWLVVVTATMALLNCPGVEGNTCPSSYPFYSCPRPGDLTKDTVCCMRSSRYSCCTPEYIQGWGIALIVVGCIFFTTLITVSICLCCRKRKRQEYTIIRDNCPQPHQHGVIVVSAPPPPPGQYGYSAMAYPPSNVSLPPPYQSKPPVAQSSPRQQGNELSENEEDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC81</accession>
    <name>A0A8B7ZC81_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Retinal dehydrogenase 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110984697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100811.1">
        <property type="nucleotide sequence ID" value="XM_022245119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZC81"/>
    <dbReference type="GeneID" id="110984697"/>
    <dbReference type="KEGG" id="aplc:110984697"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022100811.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="54296" checksum="CA743438C5692B59" modified="2022-01-19" version="1">MAPPEVKYTQLFINNEFVNSVNAKTFPTINPSTGEKICDIQEGDKTDVDAAVKAAKVAFKLGSPWRSMDASKRALYLLKLADLLVRDKEYIASLETLDNGLIIRGSRSNVDRAVGLLHYYAGWADKINGKTIPIDGNFFCYTRYEPKGVVAAITPWNAPIVVAVRKMATALACGNTFVHKPAEQTPLTALYMASLIKEAGFPPGVVNVVPGYGPTAGAALSEHMDVDVVTFTGSVEVGKLIQQASGRSNLKHVCLELGGKSPNVVFADADLDYAVETSHQALFAHSGQICVAGSRTFVQEDIYDEFVKKSVERAKKRVVGDPYSDKTESGPVIDEDQVTRILKLIKSGKEQGAKLHCGGSRSDCKGNFIESTVFSDVTDDMMIAREEIFGPVQQILKFKTMEEVIDRANNTTYGLAAAVITKDIDKALTLANSVRAGVVWVNTYSVLDPRAPFGGYKMSGMGREGGEESLLEFSEIKTVSNVSFNSLNLGYSPIIDELFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE96</accession>
    <name>A0A8B7ZE96_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histamine N-methyltransferase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110986425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103964.1">
        <property type="nucleotide sequence ID" value="XM_022248272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE96"/>
    <dbReference type="GeneID" id="110986425"/>
    <dbReference type="KEGG" id="aplc:110986425"/>
    <dbReference type="OrthoDB" id="5984880at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022103964.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37929" checksum="8F6AD3B423378B23" modified="2022-01-19" version="1">MQNGVLQWPCLQMTDIVSGVGLFCSACSHRLCKSSLVCRSTSRSTMQSTWQNLFHDTDHYLQSLKTFGAACGEFAVYVQWMETIIQETVVPKLKGALDQQGDLRVMGVGSGSGLMDYKLLVTLLQQFPRITNCVLEPLEEQLMKYHSLIESQALEQRGVNFEWRQQTIEQYEKAGSSAKFHFIIAMHVLYYFDNLEDSLMYLYSILKPGGIIMVVISSDDSGTSRFRSHMGPYHETYSVTSSADVRNVLDHHGISYSQHHERFHVNITSCFDDASEEGSMVLDFLNHVTKFKESATEDLKQQVLERLASSECSETTGDEILLNNDCDTIIISKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEE3</accession>
    <name>A0A8B7ZEE3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">LOW QUALITY PROTEIN: plexin-A2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110986460</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104028.1">
        <property type="nucleotide sequence ID" value="XM_022248336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986460"/>
    <dbReference type="KEGG" id="aplc:110986460"/>
    <dbReference type="OMA" id="HESRWLE"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01179">
        <property type="entry name" value="IPT_plexin_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12790">
        <property type="entry name" value="RasGAP_plexin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013548">
        <property type="entry name" value="Plexin_cytoplasmic_RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046800">
        <property type="entry name" value="Plexin_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF70">
        <property type="entry name" value="PLEXIN A, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08337">
        <property type="entry name" value="Plexin_cytopl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20170">
        <property type="entry name" value="Plexin_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="885"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="13">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022104028.1"/>
        </source>
    </evidence>
    <sequence length="1523" mass="169683" checksum="326CA3B475EE1C0C" modified="2022-01-19" version="1">MYSIKKINEQFNSRRKDCALGQTSNAKIPWLPNTECADQASPLRALVDMIDEEGTEYCHQQDFLYPLGGNTPIAAEAIYTDSSILSAIAVTAHLEETVIFLGDQLGHLKKLWFKSPTEAVLYEEEAILDESRPVVRNGIKFSPDKNFIYFMTERKIHKIPVEDCSTHTTCEDCLGIGNGVGDPYCGWCSLQKSCTRRSQSECVGSEDPSNLRWLGKLDQCIAILSVDPPNTPSSGTQELTLTTRGLPQLDPASSFIYKCKFGDLAMQPATLDFANNASKVRCYTPPLDQLPAVQGFLRVDLSILATETSLDIVSTNFDFYDCSTFTSCTACVGNEYRCDWCIFENQCMGHSSSCDADGIITKQQQGVPNGEMACPRIVNDGNEILIPVGVSTSFGVAAANLPLPKGFLQYQYTSDVNDLPVVLTVEWNDNYKIDNPDDLAVNLYKCEVKRPNCGDCLAGPDKYRCGWCHADGATTGDTCSLQSKCDNSWLSGEALCPDAFITDFSPKSGYVRGGTNLTITGINLGQKAEDIRSVTVAGTVCTIEQSGYIVATQVVCYTQASGEKEGEIEIVIGSGNQMDAEETVTARSEEPFRYVVPELTAVQPSFGPVSGGTSITITGNYLDAGQDVITVVGGPECKLIRRSLNELVCKTPNSAVGISQASVQMLFDGEANDASLNFEYRQDPAITGLNRYRSIKSGGLDIKVEGTNLDVIQNPEIQFTINNKTKLTLACNVLSQAEMICPSPDVSPYAVQAVPKANYGFVLDGVQNXHLPEGLDHGPALKFFPDPVYYKFDDQKNIRKLKLDQTLILEIQGENLTLTYKEGDVNVTIGDAVCKDVTLIATTLTCSPPTEQPQSKTGAEFPEVVVYHGNRNFTIGQVEYVGEDFSVYILIGAAVIIVILIIIIILCISYRKAFANDTIVKQMEAQRDQLELQVAQECKETFAELQTDMTILTGDLEAIPYREYHLYCVRTLFPDQPNHCVLRELALAGASKSRIEQGLVQFEQLVNNKPFLLTFIRTLEAQKGFTQKDKSNVASLIMVALQGKMDYSTAILKVLLKDLIEKHVEKDRARLLMRRNESVAEKMVSNWLSFLLYNFIRETAGEPLFKLFYAIKQQMEKGPVDAITGEARYGLSEVKVIRQQINYTLMTVNAIGLVKDAEPVQVKVLDFDTISQVKEKILDVLYKTLPYSHRPPKEELDLEWREEGKILQDDDSKTEGEWRRLNMLCNYPGLGDGATLALVPKQGFMSVYSSSKYMAMPSANSPARSVTTPMLSPDVDVNGTKLWHLVKPSDSEYHKSGDKVHKMMAEIYLPRLLTTKGVLQTFVDELFEMIFSVNHRGNTLPICIKYLFDLLDDQAKHHNIQNQDVVHSWKSNSLPLRFWVNLIKNPNIIFDIYKSETVDACLSIIGQTLMDACSVADHPLTKDSSSSRLLYAKDIPKYKKWVARYFEDIRAMPAISDQDMSAMLAEHSHAHQYDFHTSTALNELYFYYAITYKKQIIEELEENDYPNLAEKFRALCEQLNDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGM9</accession>
    <name>A0A8B7ZGM9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peroxisomal membrane protein PMP34-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110985580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102396.1">
        <property type="nucleotide sequence ID" value="XM_022246704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGM9"/>
    <dbReference type="GeneID" id="110985580"/>
    <dbReference type="KEGG" id="aplc:110985580"/>
    <dbReference type="CTD" id="10478"/>
    <dbReference type="OMA" id="PLEMINT"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000129">
        <property type="entry name" value="Peroxisomal membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="104"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="210"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022102396.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35333" checksum="05AD3D96772FE632" modified="2022-01-19" version="1">MSGAQASLFSYQTLVHAIAGAAGSIAAMTLFYPLETARTRLQIDDKREARYTPHIIAEIVREEGVFSLYRGWFPVISSLCCSNFVYFYAFNGLKAACLDHMKGTVAIKELLIGVVAGVINVLVTTPMWVVNMRLKLQGANFQTEQKQKSKHPHYSGIFDAFRTIIQDEGLAAMWNGMSSSLLLVLNPAIHFMVYEAFKRFISQYTGNQEHSSVVYFVLGAVSKVIATLLTYPLQLVQAKQRYDKEESESHRKLKSMWSVLSYIVRNQGPLGLYKGLEAKLLQTVLTAAMMFAIYEKIAAIIFQLMKAEKSDEKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZID7</accession>
    <name>A0A8B7ZID7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Matrix metalloproteinase-19-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110986843</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104777.1">
        <property type="nucleotide sequence ID" value="XM_022249085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZID7"/>
    <dbReference type="GeneID" id="110986843"/>
    <dbReference type="KEGG" id="aplc:110986843"/>
    <dbReference type="OMA" id="RYNDRNF"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000068">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF294">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034521871" evidence="18">
        <location>
            <begin position="22"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="19">
        <location>
            <begin position="107"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="290"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="338"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="385"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="16">
        <location>
            <begin position="85"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="14">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="15">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022104777.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="57651" checksum="43A51B83A9A47427" modified="2022-01-19" version="1">MTGVTLLLTALLVGAVTIVYSRPIENAQDAMTYLNFYGYMNQQPSDGSVPDEEEMKQAILKFQYMANLTQTGEMNAETYAKMNMPRCGMPDNVGHALDTRRKKRYSLGSKWSRTDLTYRIDNTTPDIPSRTDVDATMARAFKVWSDVTPLTFTRVFGNTPADIIIFFAPSNVDHGDGPQGAFDGPNGVLAHAFFPEIGDAHFDEAETWTIGSFQGINLFQVAAHEFGHSLGLGHSNVQGALMEAFYAGYVPNFQLHPDDIAGIQAHYGAGSGRPEVTMAPNPPAPDIPCTGRVDAVTTTQDRSTYIFEGSNVWKFESGASRISSGFPKTIASTFAGLPNDIDTAVYYPANGRTYFFKGNQYWRFNNEVMDANYPRPIRGNWGTLPNDLDAAFIWSGNNNLYFVKGNQYYRFNGGVDQGYPRSLSVWNIPGNDVAAAVQWINRRTYFFNSNGGYFRYNDGNLQADSGYPRDVASAWQGCTNTLAAATPTAGSGVNGLVPSLLALLLPIASGAVLFKSFSFPIHLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKF6</accession>
    <name>A0A8B7ZKF6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cationic amino acid transporter 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110987577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106108.1">
        <property type="nucleotide sequence ID" value="XM_022250416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKF6"/>
    <dbReference type="GeneID" id="110987577"/>
    <dbReference type="KEGG" id="aplc:110987577"/>
    <dbReference type="OMA" id="WTVEVIL"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF20">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="582"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022106108.1"/>
        </source>
    </evidence>
    <sequence length="716" mass="77741" checksum="526D0D063E2E8ABE" modified="2022-01-19" version="1">MGDVSCFRQIKDNIVRTRVVTTDLRSTPLQRCLSTADLAFIGIGCMLGSGVYVLTGEVAGEMAGPAGSISFLLSGFVAFLSAICYLECATQLPETGASYLYTYVTLGEMMAFMIGWNAVVVRIFASALVSRGWSAYFDDVIGDYVRNITVEFVLNGEEWSIPVFASYPDIVAGLVAFFACVLVAVGTEVSAKANMIFVFINIMTIALVFIFAMIHADFSFLTRHGFFPTGFGGVMTGAAACFTGYCGFEAIAFSAEEAKNPSRGLPIGIIVAFLASVLCYVAGTISITVLTDYRDINPGSPFVTAFEAIGLDWMKYLVAVGALGSMTGGVINCAFCLARSIYVIARDGLLPAFLSKTNARTQTPVIATLAGAILSVVVSVFIDFVVIIQFLSLVAFVEFVIVGIAAVILRYRPPMRSGYSAIDGSDSSSCDNEENNPSEYQDDGEADTELSGEYPRRIVKKKSRHHNPNDYNNAEQVEKSTLLGNSIEHRQQRTASTASSIYSSGSTNRRWIDKHPTTTVIISLILHLLFEFAAVALLTFKMTELKNMDGAVVFGVAVTGGLALICCWPLFVLPQYKEGIPFKVPLMPFLPLFSLLCNVVLMVRFDALAWLEFLIWTFIGMILYFTYGMHHSVEGKRREEAALRSALTAVSQLGHPPRDAVITHFDPEAESGEGVDESAERERITKARAQSLAVVVTRDGRSYSATPTYGSTDACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKY5</accession>
    <name>A0A8B7ZKY5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ homolog subfamily C member 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110987594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106144.1">
        <property type="nucleotide sequence ID" value="XM_022250452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKY5"/>
    <dbReference type="GeneID" id="110987594"/>
    <dbReference type="KEGG" id="aplc:110987594"/>
    <dbReference type="CTD" id="23234"/>
    <dbReference type="OMA" id="WLDLWSK"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000035">
        <property type="entry name" value="DnaJ homolog subfamily C member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022106144.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29890" checksum="B3C0579792CF785C" modified="2022-01-19" version="1">MPALLDSCEELFGTRDLYEILAVGKSASSKEVKRGYYKLSLKVHPDRVSSDAKEDATKKFQALGRIYRVLSDTNLKALYDETGEVDDEIDTEKCKDWADYWRILFKKVSVNDIREFEKKYQGSSEELEDLKASYLECEGDMEQILENVLCCTHEDEPRFAEILTDLINRGELPEYEAFMKESKKQKSSRRKKAKREAEEAERLSKELGLGKENGDDALTALIKQRQQSREQQMDNFMAGLEAKYCNPQPKGKKGKAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM33</accession>
    <name>A0A8B7ZM33_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Cytochrome P450 4F4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110986659</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104400.1">
        <property type="nucleotide sequence ID" value="XM_022248708.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104401.1">
        <property type="nucleotide sequence ID" value="XM_022248709.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104403.1">
        <property type="nucleotide sequence ID" value="XM_022248711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM33"/>
    <dbReference type="GeneID" id="110986659"/>
    <dbReference type="KEGG" id="aplc:110986659"/>
    <dbReference type="OMA" id="MMEINIV"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022104400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022104401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022104403.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="46729" checksum="CC11145B502C2A8F" modified="2022-01-19" version="1">MAFTESFAALSATVATLCITSSIVALVVLFIQKWKLERQFAAFPSDPERHWFMGSLSKLTADEKEVQWGKDIVKRCVTASVLWLGPIKPIVSVYHPDTVKAVVSTGEPKAEDTYSYIRPWIGDGLLLSAGKKWARNRRLLTPGFHFDILKPYVDIFQQSGNILVEKWKAACGGKKTSMEMFSNMSLLTLDSLLRCIFSVETNCQTVENHPYIKGIYDISILAMQRFRFLPFHFDTIFQWSPSGRRFRKACDTLHNYARDIIQKRKSALKEEAANRQTRHRKYIDFLDILLCAKDSDGQGLTDQEIYDEVDTFMFEGHDTTASGLSWFLYDMARLPEFQQKCQEEIDDLLVDREDDRLEWDDLSNMPYLTKCLKESLRVHSPVPNIMRTLTRPLTFPDGRTLQKGEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMM0</accession>
    <name>A0A8B7ZMM0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclease HARBI1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110986751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104606.1">
        <property type="nucleotide sequence ID" value="XM_022248914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMM0"/>
    <dbReference type="GeneID" id="110986751"/>
    <dbReference type="KEGG" id="aplc:110986751"/>
    <dbReference type="OMA" id="HITRAYF"/>
    <dbReference type="OrthoDB" id="10062286at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF227">
        <property type="entry name" value="DDE TNP4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="8">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022104606.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15267" checksum="50707A9ED8F114BF" modified="2022-01-19" version="1">MFNDGRLHGVLIGDTGYPLRQWLMTPILDPTSNAERHYNRCHRRTCVRIEQTIGQLKKKFPCLSVGLRAHPERACRFIRACCVLFNLSKTFGEPEIEEYEPIEDDDHDVIPYNGPLQDGVAHRNRIIDRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRH7</accession>
    <name>A0A8B7ZRH7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC110988470 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110988470</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107677.1">
        <property type="nucleotide sequence ID" value="XM_022251985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRH7"/>
    <dbReference type="GeneID" id="110988470"/>
    <dbReference type="KEGG" id="aplc:110988470"/>
    <dbReference type="OrthoDB" id="6096421at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="44"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022107677.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="60940" checksum="0E072F78173EE74C" modified="2022-01-19" version="1">MASYYGKDDFVTGSDLSDFSDISEDDFQVNDLSGNSSESEDDGCQYCICGRPSTTEMIACDDDQCTVVWWHYVCAGVSPSDIPDGSWICSRCRPSTSSGSQDQRQSEDLPALASSSEAGSSKKARKSQVSTGKINKASQDQQKSIPKPDQNEVFPASASSSVAVSSKKAGKSQKSTDRSDKASKDHKEKSMPKPEFVSSTAAPERPKPRFQVGDAQQRASEYFLAAFERVKKHPVFCSNYPIAMCLMSLIVNLSTASESQEFKDFCTATVSSLWIVVTAGDKKKLKPESYELMWHCFHKFRLNSIEKWKSFLVSLNLYSDGQHTHIAYQYLLQAVVELMLKDRNEFDLPRKQISDVDTKTISKEEEQVLRYVAGYVPYSLYKQFNRQINTSAKIFCHFLKSWQACPSDTAKTFLEYTNQWVKAQNRGGLFHVSDGVYLLFRTMEIQTRKILSIANLEIFPRCNIQSLVIDQIQAHPRVQTYWCSLTQGKISGANSDKLLNIVIKKWIKIRTKSFLNVYLSLKKASGAHVSKKSEKALRKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZS70</accession>
    <name>A0A8B7ZS70_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110988764</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108254.1">
        <property type="nucleotide sequence ID" value="XM_022252562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZS70"/>
    <dbReference type="GeneID" id="110988764"/>
    <dbReference type="KEGG" id="aplc:110988764"/>
    <dbReference type="OMA" id="ISEVYWR"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013587">
        <property type="entry name" value="Nitrate/nitrite_sensing"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08376">
        <property type="entry name" value="NIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate/nitrite sensing protein" evidence="2">
        <location>
            <begin position="114"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108254.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="31590" checksum="C6AE113A5CF241A5" modified="2022-01-19" version="1">MESGTENTNALLDKMVRDQPQMTASISSFGSLSMLDQSVRKLLLHSNDVSKCRENPLTIKGKRIQLAKILLLVLVPIVSLAVLAVLDLQAIAQSNGVDIEIRNVIRFSRDIGVLLSRLQRERDMTALYVSVIGPQDIKFLTEIYPETDEAIDELQDWPVETSILNELPFFQRKSDFKMHLVEHRKSVTRSDTAVYDEVNFYTDILQIFIDWLYESIGNSEGNGLWQVLVAYQLLIVSNVETGIERTLGSVFFTLGGFERHEDYVCTWSGCPTTSQRPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSN1</accession>
    <name>A0A8B7ZSN1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC110988923</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022108588.1">
        <property type="nucleotide sequence ID" value="XM_022252896.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988923"/>
    <dbReference type="KEGG" id="aplc:110988923"/>
    <dbReference type="OrthoDB" id="538607at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1037"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="111"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="215"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="332"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="443"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="537"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="643"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="753"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="850"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="1137"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022108588.1"/>
        </source>
    </evidence>
    <sequence length="1443" mass="157051" checksum="5B9DB28D79360C05" modified="2022-01-19" version="1">MVPSTGVVSINFHRSTLSPLAQLSFVLEVLVNGNRKPTMPAICEFETHKYKDKSQHKSKDTKTTVPSSPCSLDFLLQHKFNMAALLSSFAIGLLLILRVFSQLTVKGPSLVDNGTSATLQCEAPATFDRLRWVITDFSVNNPISGIFTITAQYTPSTGKTLNRDPNHYILDEADPEYPLTVTSFIADDEGRYWCSVENAPFSAIESLDVRVRVPPSTIALRYNGTSYTDGSSFTVVAGTDRPFTCITPSVKPAVNFTWTLAGGITSSQPQGSQTNTPNSGDNRLTDSSSTIIADIRESPSTSQLMCGATNRQDGLTDSEIDITVTLQVRVPPREVKLSDDEGEKVPGATVAVDQGTSHTFTCLAQGTRPAPTIQWFLNNNMPSTGIRAPTSTENNELFDTSGTWLFAPLRNHHRQQVKCEAYTAESVPPYPSAMLTVDVNGPPDVSVISGSPSMTENIETTLTCTADMGYPADWILAWLNGGSPVSGSSTNSSASGSRYSFTSTLTFIPRRQDNGNIITCTAQRGSWTPAPQQTLGPINVQFCSKSVSVSCPSKSASGSIVQLSCHSDSSNPATALVWSKNNVVQENPTQSVIEDGNYGGRKTTLWLTTGALTKADNGAVYKCSASCTNNLSDSCALNVEYPPDFSVPTAMPPGPVEEGNRVTLLCSADANPKPAGFITWERVGSLDSLPSVYNDGTSNLTLSSIRKEQAGSYRCRGNNGVPPVVHSSSVDVIVHYEVRILTKTNTSVGAKIGRDATLICKAKGHPLPRMTWQGPAGAQITNQTDPGRIFQADTVTDGDDVYGFTITSILYISQVTATTDYGSYICNSGNGVGMVDTVNIVLNDKVKPLPPEDVTVDQATVTGSAVMIAWKPGNDGGETQWFFLNYRDVETTRVFDPNTRVRIDDDIFEYMIDGLSPYTLYEIEVFARNQNGDGESVTQIFRTRPNTPENLGITATLNQDTGSISVDGIPQDGDALSCLQLEARLADQNVWFNYGDCLDTNTHLATLDIQSSYCYGNFCSLPVTALLVAGQSSNAGLIAGLVILTIIILISITVNVLAIRNIRRNKKGSQEVAGSRKLDLKSKYKPKEKRAAINEAVEYQDLDVPLQVLAISGSSHPGTSAYASISETATAFSRDKLTIVRELGQGAFGKVLLGKASGIVQLGTATQVAIKTLRDDADLTERGDLLRELDFMKQLPSHAYVVKLLGFCADGDPIYIIMEYMSKGPLKDLLTSSRGKSKQVYSNLHGRSKSLTSRDLIKFAKDVAEGMAFLASQQCIHRDLAARNVLVGENMVCKVSDFGLARDIKSRRMYQRQSEGRLPIRWMALESIVDDVYTTEGDVWSYGILLWEIVTLGARPYPTMSAKTMIAKLQEGYRMPRPDHCQDEIYQMMLTCWKEDPTTRPSFTDISQKLEKALEAPHDYITLSDYQESDYEVTIQGSPDEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSS5</accession>
    <name>A0A8B7ZSS5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110988556</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107900.1">
        <property type="nucleotide sequence ID" value="XM_022252208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSS5"/>
    <dbReference type="GeneID" id="110988556"/>
    <dbReference type="KEGG" id="aplc:110988556"/>
    <dbReference type="OMA" id="IYVGGMF"/>
    <dbReference type="OrthoDB" id="5597995at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034304791" description="Gamma-aminobutyric acid type B receptor subunit 2" evidence="13">
        <location>
            <begin position="25"/>
            <end position="832"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="529"/>
            <end position="545"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="557"/>
            <end position="580"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="607"/>
            <end position="628"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="735"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="496"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
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        </source>
    </evidence>
    <sequence length="832" mass="93515" checksum="8E44A0AD9A23A755" modified="2022-01-19" version="1">MQVQLHTVLFICLSSAFTASDADAAAEDTCISPATNDTKPRVGHDVPPLPNRTPIYVGGMFPIENNQLFGLVNDSVLAAVQHINDLDGILDGYELKMTWNWTEGLPNRALRLLYDFVYVDPPVLMVWGPMFSRVAVIVNEVAAEYNIIQVTLANSPTLPNQTRFPLTVRCGLLEDELNQPRLALMKKMGWTRAAIVFEDIEYFRSNSKDLAQTLEDGGVTVLTVEAINDKNKHRAQIINLMNHDARIIFASFYEAPASRFFCEVYRLKAYGPHIIWILNGWINDGWWRYTSTNNSTCSSEELEEVLRYHLAVHGFYEGADVDMINFGGIKPTQEQKAYMKTLVTADLSVQDVLSQSYDGMIVMALALNASVPELALLNPPRRLEDFYYGDTEMRKVFMRAVTRVQFYGATSNFSLDGNAARTGESLRVVVKQFQNTEDDPMRCILLLEQPGCDTHFTRIANNSFVWSGEVPPVDGKTFQEQVVMTSLSLRIAVVVVGTVGVVIAVYFLYINVRYRNRRAIKISSPKINNLTATGGLLLYGFVFVNSIESPDFSDSTLIVLCHLSTFLFCAGFSLGFGALFMKTFRIHRIFTKAVTQLKKVELPDRRLIMGACIPVAVDIIIIVFRFAVDDVTVMTASKDPEEDTAQLEREIFIIPFRKFCWSENELYFLGVLYAAKAILLAFGIFLAWETRLITVAELNDSKYLGMSVYVVALTVTITVPVAILKQDDVNFHYAIVSYAVIFANTTVLCLVFLPKVILFLRTEDRDLSITLMKASKFSGSTLRSLRQSDSRTDRLATALQNKLQQLDALKQDLCSMMNEEEPRTVNTDETTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTP5</accession>
    <name>A0A8B7ZTP5_ACAPL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110989032</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">LOC110989032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_022253102.1"/>
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    <dbReference type="GeneID" id="110989032"/>
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    <dbReference type="OMA" id="HESILNW"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SULFOTRANSFERASE"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022108794.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="34228" checksum="F5C78CBF02F3BD9B" modified="2022-01-19" version="1">MSDTVRVVMWTTPRSRASIVAKCMDRVPGSKILFQLSSSAYRASLDEFTSLQSGSPAEKMHDALVDPKSSDYDEGKSTYPWMKNQMEADYPGKRFVFAKEMAYCIDGKFEYLPEGYRHIFLIRDPVKVFQSFKRCVPEIIAIRGLKGEEGKLELDKLSAKLLGKELAFKEAVNVYEYLQEKNIEPDPIIVDSDDLVNDPASILPALFQRLGVEYHESILNWEKGADVLDSWVVSKRYKYRIRNVEYFRNFRDSTKFLKPEAITGTTHTGVSLTADVQRCVDFSRPYYMKLYEKRLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTT4</accession>
    <name>A0A8B7ZTT4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110989136</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110989136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
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            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="RefSeq" id="XP_022108978.1">
        <property type="nucleotide sequence ID" value="XM_022253286.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110989136"/>
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    </dbReference>
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        <property type="entry name" value="SULFOTRANSFERASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022108978.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34161" checksum="7FE5C2B6E45C9234" modified="2022-01-19" version="1">MSDNLNRVFLWCVPRTVSTAFLKCISFVEGLQVVNEPYQCAFHSGPERKSPQLDLSSPVEKRLAEILDHTSADGDVRCFDEKDCTYGWIRDELLEAYHPCKKILFCKDMAFYLDAKYHMLPKGFRHSFLIRHPAKVFLSWRMSLLKTFGEPCAKHMGNLQELPECVFPAGCGFKEQYDLLEYVERHLDKEPVILDIDDLLSDPPNILSAYCHKMDIPYSPGLLSWQAGGAIADTWIASKAMVNANKIGGFYDDALQSTMFRSPEPPPVIENLPVDVQACVKASMEYYEKLHSRRIKPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU06</accession>
    <name>A0A8B7ZU06_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110988052</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110988052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106966.1">
        <property type="nucleotide sequence ID" value="XM_022251274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZU06"/>
    <dbReference type="GeneID" id="110988052"/>
    <dbReference type="KEGG" id="aplc:110988052"/>
    <dbReference type="OMA" id="RICIDVT"/>
    <dbReference type="OrthoDB" id="6128227at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="574"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="603"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022106966.1"/>
        </source>
    </evidence>
    <sequence length="844" mass="93274" checksum="DD54D0057E5FE4AF" modified="2022-01-19" version="1">MARRQVPPDLDGRGDTFPFKRGEGESFATRFMRRLRSGPKVAPVSLHDPNNESSLDTNNGSQGTPSIPRGDNEDPDGLRPGDKTWEAKKSHIRDHLGFLKFLRRYRHRKVVPLNGFSDREHTPPSAPRDGPGLLKVTSRNGDHAPDTLTSLKNAYTNGDAFSHRQDIGKYTTVKLKTTLQRNEHRDRNDADSSQQKCQTCPPGQEDSSPDSSEEIQTEQPLCCPDVIRVASKQLPEASPDKEESSLDRISSSRCESPTTSLVSASLLVKEASPGTSSQGEPPKSAGEEMMSALSSLGKTNPRSFEVAQPDLTGGTLPRALKNSRINSHKLPSLASSPQSGTSIVSPPDSRNVLDVTPDVLADEMRTLSPGARQRRIQEITAYIKRRVDLQTLKDLTSNTSIYTSNEKKEIEENADRAEVLLGRLKILIKGAKKRKQQVSSTSQHNQQRQAVHGHVNKTKTCVSGNGGCSPQNGASSQATQVAKVTPSYVPQLALPSTPKVPSGKSAIPTPQPSTKPSKSKAPSPCPAINKRTFRKSVQKQGSPAQPKATSSKDLQALGLPIIDEKDVQPVETKKGTPIKLGCGDYGNVYLMRSHMDGTLMAVKRLTQFGGCQSQDKRTQEMLREIRAMEAVKSCRVFPKFLGVLDLYSFGQEFVGNSRTMKSWSAFKLLYRNSRGPRLLPLDWVRICIDVTEGLDTFHRAGWTHNDLHVGNIMVWRDPKKLTATWEGKIIDLGKASRIKSPPPPKILTFVQMMFAFKNCTQLAPEIVEGRSRYNVKSDIYSLGIVLQDIAKENRLLSGFKTIGDRCVFEEPNRRPELKTILKELNQLCEKFVSPRRVGKTKGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU71</accession>
    <name>A0A8B7ZU71_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110988099</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022107041.1">
        <property type="nucleotide sequence ID" value="XM_022251349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZU71"/>
    <dbReference type="GeneID" id="110988099"/>
    <dbReference type="KEGG" id="aplc:110988099"/>
    <dbReference type="OMA" id="HRTQDSV"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000303">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034488797" description="protein disulfide-isomerase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="339"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="46"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="400"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022107041.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57659" checksum="6BDA6DC13FD0F720" modified="2022-01-19" version="1">MKTFLLISVLLGLALGGDVIELTDDSFKSEAARHDLMLVQFFTAWCGHCKKLAPEYEKAATVLKSNDPPVPLAKIDCAEKGIETCGDYGVSDFPSMKIFRNGKLSSEYQGARKADSIVSWMKKQAEPMAKKVDDVWSLQKILDSSHQPVVAGFFTKDGKEKENLVEAAPDLFTHYRVVYSLSEEVNEEFGYFDAVVLFRPAYLRNKYEGNEVEMSGAITKTNIEKFVGQNGMGLCGHMTPLNVDLFRKPLVVVYYEVDFLKNPAGTNYWRNRVMRVAQNYRDEGLTFAIAWKAQFEDVLGSLGISSQTEISVVAWQHGEKFKMEEAFSVTTLDTFVKKFLAGELKPYIKSEDVPEFNDGPCQGRFNSCHLFPQVVVGSTFNDIVKDDTKDVLIEFYAPWCGQCKAMEAKYTLLGEKLKDVEHVVIAKMDITANDAPVEYAVIGIPTIYWAPMGSKSAPKKYQGGREVNDFLEFIKRESTLPVDVGEKKKSTTDEFIIRMLVEDVLYGREKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWC3</accession>
    <name>A0A8B7ZWC3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catenin beta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110989627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109853.1">
        <property type="nucleotide sequence ID" value="XM_022254161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWC3"/>
    <dbReference type="GeneID" id="110989627"/>
    <dbReference type="KEGG" id="aplc:110989627"/>
    <dbReference type="CTD" id="1499"/>
    <dbReference type="OMA" id="DPLMFDM"/>
    <dbReference type="OrthoDB" id="195736at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000015">
        <property type="entry name" value="Catenin beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013284">
        <property type="entry name" value="Beta-catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45976">
        <property type="entry name" value="ARMADILLO SEGMENT POLARITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01869">
        <property type="entry name" value="BCATNINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="167"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="209"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="251"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="293"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="416"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="458"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="505"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="547"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="610"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="703"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022109853.1"/>
        </source>
    </evidence>
    <sequence length="813" mass="89107" checksum="6A464D377823D33A" modified="2022-01-19" version="1">MEAQRQKPFAASPAGQSAYGSPALADLPKQDPMQQTLDWQHHGYGMDSGIQSGVTTQAPSVSSKSHHDEESEMSAGQGMFDWDSSYGQAYTQEQVDEMNQQLNQTRSQRVRAAMFPETLEEGVQIPSTQFDPNHQTSVQRLAEPSQMLKHAVVNLINYQDDADLATRAIPELTKLLSDEDQVVVSQAAMMVHQLSKKEASRHAIMNSPQVVAALVRAMSNSNDLETTRCAVGTLHNLSHHRAGLQSIFKSGGIPALVKLLSSTVESVLFYAITTLHNLLLHQEGSKMAVRLAGGLQKMVMLLARNNVKFLAICTDCLQILAFGNQESKLIILASGGPAQLVRIMRTYTYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGMQLGHQSNRLVQNCLWTLRNLSDAAVRMDDMEGLLQMLVQLLASTDISVVTCACGILSNLTCNNARNKITVCQVGGIEALVRVVIQAGDREEITEPGVCALRHLTSRHPEAEMAQNSVRLHYGIPAAAKLLQAPSHWPLIKATVGLVRNLALCPANHAPLREHGVIPRLVQLLMRANQDSQRRQSGGANGQSFTDGVRMEEIIEGTVGALHILARDMHNRMLIRNLSTVPLFVQLLYSNVENIQRVTAGVLCELAQDKEGAEIIEQEGATAPLTELLHSRNEGVATYAAAVLYRMSEDKPQDYKKRISVELSNSLFRGETAPWGEPMDMPDPSVMQQDFSHHTSASSLHSDYRHQQPPQQQQQGGAMHMQGNYNEPMSLEPMMQELDLGSHTDYGMDPTLANLGPPSGDLNLDTLPPTDSSGLAFFDTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWS8</accession>
    <name>A0A8B7ZWS8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110989730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110989730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110003.1">
        <property type="nucleotide sequence ID" value="XM_022254311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWS8"/>
    <dbReference type="GeneID" id="110989730"/>
    <dbReference type="KEGG" id="aplc:110989730"/>
    <dbReference type="OMA" id="RTPAQIW"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034219514" evidence="7">
        <location>
            <begin position="16"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="134"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110003.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="39562" checksum="45F111BE76F5A3A5" modified="2022-01-19" version="1">MKLLLLCLCVVLAHAGLAPLRTTNERSVPDSWIIKVEDFDLLERVQQEIEDIFSTFRAPAPRISKLEDLMPVLTLKIPQHILTRVRAIEGVEYIQEDTIATLFGSQNNPPWGIDRIDSRTGTDNVFNFNDSAQGEGAKIFIVDTGINTNHEAFGGRASLLYGVADDGGHGTHCAGTAAGEIYGIARKAEIYSCKVCSHGACGLSTISKGLNAIVKKFGSGPGMGVVSMSLGGGYGPYFNSLVQNMLNKGYTASVAAGNSNQDACNVSPASLKGALTAGATTRKDKRVYFSNWGSCVDLFAPGVYIKSASHSSNTGTATMSGTSMACPHVTGAAAVYLGSNPGSSPSAVHDAIVNNATPDVVSDPKGSPNRLLYVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX22</accession>
    <name>A0A8B7ZX22_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PiggyBac transposable element-derived protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109647.1">
        <property type="nucleotide sequence ID" value="XM_022253955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX22"/>
    <dbReference type="GeneID" id="110989510"/>
    <dbReference type="KEGG" id="aplc:110989510"/>
    <dbReference type="OMA" id="RRESHYI"/>
    <dbReference type="OrthoDB" id="9986773at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46599:SF3">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109647.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="20154" checksum="6458D00FD0BE5A29" modified="2022-01-19" version="1">MADIHGTGKQGRTGQEKQKPTCVIEYNALMGGVDKSHQLAANHRATRKSLKWYKKLFFYLLDLMLVNSYAVYLAVGHRLPFLDYRLSLVRELLFDKPLPEYRPQYDTPPVTNSRFDGRHFPVDFERTSYGNFRYRRCVFCASNGLRQKTHFERNTCHQPLCVAPCFKVLLSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZ71</accession>
    <name>A0A8B7ZZ71_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110989075</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108881.1">
        <property type="nucleotide sequence ID" value="XM_022253189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZ71"/>
    <dbReference type="GeneID" id="110989075"/>
    <dbReference type="KEGG" id="aplc:110989075"/>
    <dbReference type="OMA" id="IWSINFN"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="7">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="128"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022108881.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="53923" checksum="698A5B10C988E3D0" modified="2022-01-19" version="1">MAGRFVRSSKYRHVFGTASKPDQQFTSIRGINDGATDGHICAVNPKFVAVATKPSGGGAFLVLKHDEAGRIDNEHPQVRGHKGKVLDLAWDPFDDNVIASGDEHSIVCVWEIPDSGLTESITEPRVTLDCHQKKIVKILWHPTARNILLTSAWDCKVIIWNLETVEGFLEIETPDVPYSVDWDYNGSRIVVACKDKKIRVYDSHEGTKLSEWNGHEGTKPQMVAFTKQGVLTTGFSKMSTREYALWNEKTGEQLAQEDLDSSNGVNQIIYDRDTGMFYFAAKGDSVIRYYEMTGEDPFLFYLSTYQAKPQTAVGIMPKRGCNVNACEVMRFYRIEKADKGNTSQFVIIPTAMTVPRKSETFQEDIFPDTPGDEPSMTAEEFQSGKNKDPILMSLKSGYKPKEKSVRAGGIMKKVDGGSQLGSKMQSKGLSGDKSGSGAGQSTATGAASTELSALKDEVNSLKATVESQQAKIEALEGKLEELAGKVNQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A018</accession>
    <name>A0A8B8A018_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kielin/chordin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110990153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110702.1">
        <property type="nucleotide sequence ID" value="XM_022255010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A018"/>
    <dbReference type="GeneID" id="110990153"/>
    <dbReference type="KEGG" id="aplc:110990153"/>
    <dbReference type="OMA" id="NCIRITP"/>
    <dbReference type="OrthoDB" id="1725934at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036201">
        <property type="entry name" value="Pacifastin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57283">
        <property type="entry name" value="PMP inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034781743" evidence="6">
        <location>
            <begin position="17"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="7">
        <location>
            <begin position="301"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110702.1"/>
        </source>
    </evidence>
    <sequence length="972" mass="104790" checksum="D475086956F8F393" modified="2022-01-19" version="1">MKLFYLLVIVGVVVRGQEIGEPGGTGPVPPCQAEIDVASPGDVLPECDESGFHAPKQCNADRSLCWCVTRCGDPIMDTKGGPDIICEQDDPPCIQELESSSGGRMRLGKFKPRCHESGFYHHTQCKGSVCWCTDRCGNRMESSSYSIGRSGVCDCDDGDYAWKCTTNPCDLETTACPAHPDAVCKPSACGACVAKFYVGEKEVDCALPEPSVLGPEPEPGPEPGPEPGPEPGPEPGPEPGPEPGPEPGPEPGPEPGPEPGPEPGPEPEPGPEPGPEPGPEPGPEPGPEPGPEAEPEAEPELMCTDTHGTKHKAAERWKMDKCIECHCQNGEAVCMTPMCAGPLMGWKYCTIKAGMEDACCPEFDCVGCLDSERLNHYDVGETWNGEGDPCNACRCVGNNRVSCVREICPGVNRYIPPLCRWVILPGECCPRDQGPSGIVCDEPISACIPGSAVMPDCPSDLCLTATCEGHPDAQCKISHCGTCHTVFYDSDGVKLDCLNEPVVHEPTCSDEAMMTCLLSPCDAGAVCDGHPDAVCYVDYCHQCEAVFFDKRNQPLACRAPHDITERCDEIHNVGDHWDENCMTCECTSDAFIACVPNECGEPPSPLPLRCRLVKQTPEECCPSKVVCEEAISDCPVGASIAPSCPDDLCNTTCEGHPEAVCHISRCGGCFAKFFDEEDQVVQCVGGLVEVEPKCPDGSLQAQCLVSPCEYATCKYYPEAVCHVDYCQPCEAIFHCPFNKELNCLEKRKEETEECKDSSNIKHDVGETWMEGCNECTCTETGIPACRAKTCDTATCEGGYRVGERWQTTCMTCECSPSLTPVCISHECGQAPPLPDRCYWAKQTPDECCPSKRVCEEAISACSEGSSVAPSCPDTLCDAPCEGHPEATCLISRCGGCVAKYFDENSQRVQCEGGPVETLPECPDWSPPTCLIAFCELAECERYPDAVCHTDYCKPCDFVFYDDHNQKLDCSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0L3</accession>
    <name>A0A8B8A0L3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990494</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111219.1">
        <property type="nucleotide sequence ID" value="XM_022255527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0L3"/>
    <dbReference type="GeneID" id="110990494"/>
    <dbReference type="KEGG" id="aplc:110990494"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111219.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="14377" checksum="7BBC435F46228913" modified="2022-01-19" version="1">MQTRGLADVMSVEPTKMVSAMGVIIIAAASTLVSAKVCVLGTEPDPGDRGRVKFVIPPGDPCTCAEVRLGGHNTYAPPRRRGTVYVGIGDLQKISADGLREHFHCTTNKPERILTSNPRGEVCRGTLENSGACPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1Q6</accession>
    <name>A0A8B8A1Q6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110990276</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022110900.1">
        <property type="nucleotide sequence ID" value="XM_022255208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1Q6"/>
    <dbReference type="GeneID" id="110990276"/>
    <dbReference type="KEGG" id="aplc:110990276"/>
    <dbReference type="CTD" id="79071"/>
    <dbReference type="OMA" id="MQANWSK"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022110900.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="37004" checksum="782FB9E0F0C2C4A4" modified="2022-01-19" version="1">MAHSALEYTDNFPFDNYEVLASSNRSVWDPKHSFKFEKFDMQEVDASLMWFQNNWTKSIVYSALYAVLIYFGRIYMENRPRFDLRLSLVIWSFSLAVFSWIGAIRVWVYTIDFIRAYGWKASVCDPTLYKGVVGFWSWLFVLSKLPELGDTVFIVLRKQKLIFLHWYHHITVLIYSWYTYPQLVAPSRYFVLMNFTVHSLMYTYYALKASKWVNIPTWVNIVITSLQIAQMFVGCFVNGYAYSIRSNGGFCATTDANLRASFLMYLSYFVLFVHFFIETYVTSKRKQRALAEKSQAQNILQDSNDNTKSEKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2H1</accession>
    <name>A0A8B8A2H1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein LOC110990774</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111567.1">
        <property type="nucleotide sequence ID" value="XM_022255875.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990774"/>
    <dbReference type="KEGG" id="aplc:110990774"/>
    <dbReference type="OMA" id="GHHEYIN"/>
    <dbReference type="OrthoDB" id="6110576at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057191">
        <property type="entry name" value="DUF7869"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33153:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25273">
        <property type="entry name" value="DUF7869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7869" evidence="1">
        <location>
            <begin position="340"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111567.1"/>
        </source>
    </evidence>
    <sequence length="712" mass="82299" checksum="B9762A6426349DB1" modified="2022-01-19" version="1">MTARMSMNVLLDPCFNHLEIYQDIQLRSCMISVLQPTVSKLSEGPWHKGPILTANTANYDVVLPRHTPLGTIRAAEEIHSTTYQSTEAQQPPAAQINSVTPTETGDDWIPPVDLSHLSDQQHQLATQLLKREWCVQERKXGSLHLCIICWELNRKTIPDRQPIPQMQDALNSLEGNTWFSTFNQGKAYHQGFVVEDSRAATAFITPWGFHEWLRIPFCLTNAPTVFQRCFLEPKKHMMLDNTDLPHQTISVQSIVEPLRENRFAKCDRCTLLRTSIXDKSKRKELYEKRDRHLRLQNNERCKYYKHIQKSKASHRQYISIIIDGVDQKSTSLPKFLIEPKSMSSMWKLPTHITGVIVHGRGHHEYINIKELPHDSKLTINVLLQTLLKYPSLPPTLYLQLDNCGREKKNXVLALCCLLVELQIFKKIKVSFLMVGHTHEDIDQMFSRFSMFLWRHKVHTLSRLPTALPEAFNKPDTTAERLGKSVNFRDRIKPHLNEVADHSRPHAFKFTRDRTGKAVMHTKGWGSTGDEWLPCTCTQENVPCYQLLNGHPDGQPDVVQLDFGPLNLDRLQRDIAKLKVLASSQSRTFWQTRLLQSRRGQYTYWINRLKMSSSLWEKRANKNHQAELKVGKMIGTHLTAYTHDWPQIGEIISVNDKDDIIQLVWYTGTYSSKWKPLNKKIPRKRGVQAWKEGIETSCIICDLFDLTRATKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A500</accession>
    <name>A0A8B8A500_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SHC-transforming protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110990360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111011.1">
        <property type="nucleotide sequence ID" value="XM_022255319.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990360"/>
    <dbReference type="KEGG" id="aplc:110990360"/>
    <dbReference type="OrthoDB" id="9938362at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01209">
        <property type="entry name" value="PTB_Shc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09925">
        <property type="entry name" value="SH2_SHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000377">
        <property type="entry name" value="Shc transforming protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000005">
        <property type="entry name" value="SHC-transforming protein 1 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051235">
        <property type="entry name" value="CEP152/SHC-Transforming"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006019">
        <property type="entry name" value="PID_Shc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035676">
        <property type="entry name" value="SHC_SH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337:SF11">
        <property type="entry name" value="DSHC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10337">
        <property type="entry name" value="SHC TRANSFORMING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00629">
        <property type="entry name" value="SHCPIDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="46"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="593"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="411"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022111011.1"/>
        </source>
    </evidence>
    <sequence length="695" mass="76750" checksum="035AC896F6F94430" modified="2022-01-19" version="1">MNHFKKNKGPNTVGQRHNEELWTRTGTFVNKPQKGWLHSEEKVKHGGVCYGVTYVGCIEVKQSMRTLPFEMRGQVTKEAIFRVCDAAGFRCNRKKKGSKAVNKILGDVPNIQFGRANVNLTISTSSITLTIMETGQVIASHQMQGISFASGGDAETADYVAYVGKDPVNGRACHILECLGGLAQDTITTIGQAFEIRFKDYLKNPPQAVNAPDRXAEPIFGEEESAWGDDPEYYNDISKFTNLPPQEPFPPPPPPGHYMKCQNVPDNHPYQPLGAAKPSAPPVYDNREGGFEGREQYNNERQPAVGKLLDIDDTPQAPVLDNPLSNQVRRVHSQDNHTGQASSEITTVQSVCDKKASQVKHFKRCTPLFYDNPPQNLPNKKVNEITKLKSNSPDWRGILEAGYDNLRIPWNRSRKSSKSKPHKGGNTIYDEPRFDTANYDNPKMPLVPSDMDSQDGVYNIPTPNQPLDLGISHNGQNQPSPVVDAFDMEPFNPAASFPREPVSVPPPPQFTNSAQPPVPQPRKSPPVQQATPPAQSLAKPRIPPPPTHKPPPPPTSGTPPRSGSPIVGLPQRNNQPANVTPIQPKKSILDEEWFHGPMTRKIGEALLEEDGDFLVRESTTTPGQYVLSGMLSGQPKHLLLVDPQGKVRTKDREFESVSHLINYHRNNNLPIISGGSNVYLQHPVLNATAAGKHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHQ8</accession>
    <name>A0A8B7XHQ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable isoprenylcysteine alpha-carbonyl methylesterase ICMEL2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973342</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079766.1">
        <property type="nucleotide sequence ID" value="XM_022224074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHQ8"/>
    <dbReference type="GeneID" id="110973342"/>
    <dbReference type="KEGG" id="aplc:110973342"/>
    <dbReference type="OMA" id="STYCLLA"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="BD-FAE-like" evidence="3">
        <location>
            <begin position="124"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079766.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44322" checksum="4ADED2B5890D48B3" modified="2022-01-19" version="1">MRHSSMNKLGRVILGASLLGLGIPYVLVVAVNCLMGWPNSRPEEGSRFQRALHPTRVLNLNYVFVQQVGMLQFLPLYLRFWKFYREAETVTRDIPYGRNSNTLDIWWPSANQSLAKDASSTDPSQQHRRPVFVYVYGGAWGSGDKNLYGLLAQSLADRLEAIVCVPNYSIYPKGIVTDMLHDLADTIAWIKTSELIRSLGGSPEQIILCGHSAGGHLVAMVTLNLAHRSVTEVQNSETSKSSSEALSLLSSVRGVIAISGVFDIADHYQFESWRGVEDMSYMWRAMDGRANFAKYSPTLVLKELDSQQIAKLPPFILIHGTEDGTVPVSASEKFASALSEDGAPVSLVIVSGGGHAPLVLDMMEEGRPFYTEMTTVVMEHVKRVLPSSTLPRHLTPPKGSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIH4</accession>
    <name>A0A8B7XIH4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sialidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080006.1">
        <property type="nucleotide sequence ID" value="XM_022224314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIH4"/>
    <dbReference type="GeneID" id="110973468"/>
    <dbReference type="KEGG" id="aplc:110973468"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034579132" evidence="2">
        <location>
            <begin position="25"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080006.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="28155" checksum="3AECD7E8AF774E0B" modified="2022-01-19" version="1">MAFFWFFRLTFLLWLSALVNHSGTQTTQLSSPTSSTQTTQLSSPTSGTQTTPLSSPTSGTQTTPVSSPTSGTQTTVTSATATINTSSFHETTAVKTTSSLSDRTTVSLTAEVTTHSETTAATNLHGTTVVTTKEGCGLSEDSCTTNGVFLKESCECLCKKGFAGVICEVSTEKNPCTENPDLCQERGQYCESDTKITDGKEYVCKCNSLEGYVEKDGKCIEEEPFTTKLDVTIIDGKEATYKPAHRDINSAESRKVLDAVIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIK4</accession>
    <name>A0A8B7XIK4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein AF-10-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110973421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022079952.1">
        <property type="nucleotide sequence ID" value="XM_022224260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIK4"/>
    <dbReference type="GeneID" id="110973421"/>
    <dbReference type="KEGG" id="aplc:110973421"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20901">
        <property type="entry name" value="CC_AF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15672">
        <property type="entry name" value="ePHD_AF10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15574">
        <property type="entry name" value="PHD_AF10_AF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000042">
        <property type="entry name" value="protein AF-10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000053">
        <property type="entry name" value="protein AF-10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049773">
        <property type="entry name" value="AF10-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049781">
        <property type="entry name" value="AF10/AF17_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF164">
        <property type="entry name" value="ALHAMBRA, ISOFORM P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13831">
        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="62"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="281"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="776"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="828"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1028"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="851"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="903"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1034"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1049"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022079952.1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="113101" checksum="C55C01AE7723515B" modified="2022-01-19" version="1">MKEMIGGCCVCGDERGWTENPLVYCDGQVCNVAVHQACYGIVTVPTGPWYCRKCESQERSARVRCELCPQREGALKRTDSGNWAHVVCALYIPEVDFGNVTTMEPILLSSVPDERYNKTCCLCMTKGRESKAAVGACMTCNKNGCRQSFHVTCAQQDGLLCEEAGSYNDNVKYTGYCSYHYTKLNKNKDIKTIPPFKPLGSAYSTPEKPADRTSADRTDRTDKTDKSDKLRLEKANKVKPERKNRFCIAEASAALLAQQESAAEARAAEAKAAEARLTEAYAAESKSATVASSSPSGGGGKQDDPSGKFTNANFTETVIGPTGTPPSASAGAEDPSSGDSSLILKFTRNTVTQPGHRGRKSNSQKSDGPGSADGQSTSTSSKLGGSEFSVSYSERVSSPNQAVEDSNSSLKPTKSKKGSSKSNPATPTPTTPMVVTETVMVKDLPPEKSRGTPTVDVETVLSPTRSGPGKATSYTDAYEEFMAKYKSDQEDLPGKRKEKEEEVSPDPPTPTPTPTLTFPSVSKMVTSKPAVHKPSSSKPAISTTSSSGDETSKRERKKHRSGKRKDGKINRPRSTVRSLGGGDGVPSKKRRSSGSSAGSPSGLSMPRLSFSGPGGSGGLSSPLSSSSLPSFLSPAVNHEDSAIQDVFNMAGQSGLIGPQSRLTSLHNRQHMEASQSTGMPATMEQLLERQWDQGSEFLMQQATHLDIASLLSCLYQLRQENTRLEEYILSLVQRRDHLLAVNLRLSRPLNQGGSPDNPTSRRSPRFNNVIHSDATTLSASSQDLNSSRSSTQSLNHSLNHSYNQAPALPMSQSHATPAINLNHAQLPLHRSSTPQNNGVAHLPVVPGPGVSQSSAPSARQSPAHSHTSTPVAAAAAAQGAPGHGQATPPPGRLTPGHGPGRMTPSQDRMTPVQVKTTSGQGSSGHGSEVHKRVPSRDSTSTESSHSSRDSTSRDQLGLPGVNPGSHPAMVLQHPQLSSLVQQHLTPEHQHLVYQMMQTQNQAGLGLSVLLPPGIGTATTTTTIMPLNGELPTLTGHSQSQNTSRPKSPRGGDRRQTSSKDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIN4</accession>
    <name>A0A8B7XIN4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110973441</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110973441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022079977.1">
        <property type="nucleotide sequence ID" value="XM_022224285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIN4"/>
    <dbReference type="GeneID" id="110973441"/>
    <dbReference type="KEGG" id="aplc:110973441"/>
    <dbReference type="OMA" id="TGPHIAM"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01472">
        <property type="entry name" value="vWA_collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000004">
        <property type="entry name" value="collagen alpha-6(VI) chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF87">
        <property type="entry name" value="COLLAGEN ALPHA-1(VI) CHAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="203"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="9">
        <location>
            <begin position="907"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="749"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022079977.1"/>
        </source>
    </evidence>
    <sequence length="1188" mass="131053" checksum="1242DE5BD347AC8E" modified="2022-01-19" version="1">MEKTAIGALPGLVVVASVITLFAQPTRSQGTDLTTIPESFGVAVVEATVRRINRLDGINRDLRADYRFIRRIAWVETTDGTDQFTYSDQNYHGGIWRVDRSVYDFTMTMYNNPRYASLFSDVEALMQINWSRTTWQDCRKPLYSALAARLYFHSIQPNIPQGITLQATLWRTRYHDQPSDTVGDFIAKVEDLESEGCSVNQIDLVFVLDSSGSVGQSNFEKTKSFVSNVSESFQIGADQTRVAVIQYSSSVKVEFHLNTYADKTFLQEAIRNITYIGGGTATVSALNVTESQAFLVENGARPDLNSITRAAVVITDGRSQGPAAVAVPADRAREKGITIFAIGVTDNVNVEELNAIANKPNDTYVFHVSNFDAIDNIVASLEDKTCNDPTPIRGPVVMNTLVQGDTQYLQQAVSNEGVTLVIEADQGNVAMYISTTTPNPNKAFYDYLLKATAGQGKVEVYIGPEEFVNQGNLSIETGGGGDRMRRQAPGQNDTDDGSPIGTVYMTIEGLQETNNFVLRVTEGDVTEPVTTSITMTRNMATTKESGTKAAAYLAVGLTALFTTQLLKSESFKLNTPEADDLSVLRHSLSKNDGMQINNGLKLICAMYVPLYNEYCTQEQEKNQRATVPCGSLQANNAKFFFLALLSIVRKQEVREARFTFSKGLSQRYFSPLSLPSLALVIVLNLSALGFCRRQACVVLQLHTDSILEMERKAIGVLPTAILLVAFLPPIRGVGIDLTVVANKFNTTVVEATITKLNRLAEVNEDLRANNRFLRRIAWVETEDGTAAHTYSDPTYHGGIWRVDEAVFDATTRMVNELVHLSIFDDIERLFCIRWSRASWEDCRKPLYSALAARLFFHNLNNVIPLALEAQADNWFREYHALPTVTAETFILKVTTLEQTGCNARGLDLLFVLDGSGSVGSVDFNTTKNFVLTMIDFFDIGPDKTRVGVIQYSTLPHIEFHLKDNTEKAQLKRAAGNITYRAGWTHTGAALNVMSNTSFLLENGARPPSRGFPRVAVVVTDGKSQDNVTEPAERARDMGIVIFAIGVTSSVKGLELNAIANEPNDTYVYHVNDFDAIVNIAAALEYTTCDQPTELQNGTANGFLDRNEKQNFQYAYTSKGLTLSLNGSQGCTVAYISASTPNPNAASYDFILMAKEGQGTVTLHLTVDDLNKNCTSEFARERREMAPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJL2</accession>
    <name>A0A8B7XJL2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mucin-2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110974008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080983.1">
        <property type="nucleotide sequence ID" value="XM_022225291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJL2"/>
    <dbReference type="GeneID" id="110974008"/>
    <dbReference type="KEGG" id="aplc:110974008"/>
    <dbReference type="OMA" id="LVESHQY"/>
    <dbReference type="OrthoDB" id="10071929at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034999567" evidence="3">
        <location>
            <begin position="39"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
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            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
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            <begin position="445"/>
            <end position="459"/>
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            <begin position="468"/>
            <end position="477"/>
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    </feature>
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    </feature>
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            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
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            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
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            <begin position="695"/>
            <end position="741"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080983.1"/>
        </source>
    </evidence>
    <sequence length="1105" mass="111622" checksum="12BBA50755EA9F40" modified="2022-01-19" version="1">MAPLSFRFCGVTSASMRLGPALCLLVLLNIVGSSHVAGQTPTGTTTGSDGSMTPAGAETSVATSVPTTAASVDSDGQATMGSTTLASLQESTASLADAGSTFSTAQLATSDSVASTAAGSAGGSTQPMSAWNGTTPETEGPQETMQPDMSTSVSDAGVTNAGDSQVPLATESVTTAAASVTVAANEGPRDDIHEVGGPGIITVAAFTTAAANELTPDGGNTAPGSVPESTSAAIFTTAAANELTPDEGNTAPGSVPESTSVAIFTTAAANDLTPDGGDTTPRSVPESTSAAILTTAAANELTPDGGNTAPGSVPESTSAAIFTTAAANELTPDGGNTAPSSVPESTSVAILTTAAANELTPDGGNTTPRSEPESTSVAIFTTQAATELTSNGGDVNQSTIPERQDTDTVATAVQVSVDMSTSSTAPPTSSEVTPGAPETPMVSGTDFSSMAQATGSSDGPGTVAVTPASHSTQSQENTASPAASTEPASAGSTQLVTIEAQTTAASPTTEVAASMPVATSAPVVDGTIGYSVGSTPPSATAPAAAQTGESTTSGSSPETTFTVSETPSTVQTVDRHTTGWPVSTAVATSAETGLLSTQGPLFVSTADTSAAVTLPSVDSTTAAMSPSPIQVESTSEVLTSVQRPVVKPYQNTTTTAFLTDDGTSPFAASTVVPTEALSAVTSQLPAETTPPSAKTTLPPAETTLPPAETTLPPAETTLPPAETTLPPAETTLPQTGTTQLPAETTLPPVETTQLSAETTQLPEETTQLSAETTQLPAETTQTTVATTQPSVVTTQTPAAVTTQALAETTKLAETTLQPTPAAATPQPPADLTTETQRLTTGVPVVATFMPSKPQFKPLSTLTEEEKKGTFTVESRGIMRDNWLAQKDVIFRNTVAPMLRNKSRKRQAPSTVQAEDIVYVSPSPVVKDGVLHITFFARSRGGDSGESVIDGNQVVGILNTESNMNEMKTALKVNDIKVYPGISSAILLQDTQTGVSIFGSRALFIGLIAIGCLSLVIIVAGFIYLVCDRKRGRSGEYITHHVNPDLEVGLDNPALMTEAGDKTAAINGNGAHLLSFKTDPEDGDIVPYNSFSPEDLANCEVEDTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XK82</accession>
    <name>A0A8B7XK82_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Neurogenic locus notch homolog protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110973782</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080566.1">
        <property type="nucleotide sequence ID" value="XM_022224874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XK82"/>
    <dbReference type="GeneID" id="110973782"/>
    <dbReference type="KEGG" id="aplc:110973782"/>
    <dbReference type="OMA" id="YCEVRID"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000057">
        <property type="entry name" value="protocadherin Fat 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
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            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
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            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
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            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="474"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="512"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="553"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="591"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="629"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="666"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="708"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="746"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="787"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="827"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="307"/>
            <end position="316"/>
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    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022080566.1"/>
        </source>
    </evidence>
    <sequence length="939" mass="98477" checksum="193E5BBF1C9A5547" modified="2022-01-19" version="1">MKTQVKQLGLMLVVVAIHQLATCRAQGCNPSPCLNGGLCFSSLTRPSGFICICSQEYYGQLCQNLVTACAPNNPCENSGQCVLSTSAAEGRVCLCQSGYSGVNCTIRTAPQNGCSPDPCQNGGLCYVSSTSGSYRCICNRGYSGNNCDILDPLCSPNPCQNGGSCTVHASSTGRTSRCRCPSGFAGEFCNVTANLYDCTENSCLNGGSCFASTQTPGTYRCFCRTGYTGEYCETLDQTPQPNGCNSNPCANNASCMISHANSSHYYCLCPMGYQGENCQEASCGTGSSPCLNGGTCVLTMGGFRCECARGYGGTLCQTMVTCEINPCQNGGSCYSDFQGGVTYMCRCSNGFKGHDCDKIDPCLSNPCGSNRRCLMEEDGSYVCLCQCRPDGTCEIPGSTCLSSPCLNGGTCRPNIDEGYTCQCPYGYAGDQCEIRNDTTSCPSNPCQNGGVCSSSGVAFTCTCAAGYFGTLCQYSFCSSLPCQNGGSCQLTASGYRCQCAQGYFGTYCENSEQVGCASDPCNNGGLCYDSPTSPGAYFCVCAEGYAGTNCNISANACVSRPCLNGGTCEPRSTGFQCQCAQGYIGTYCQTRRDDCSLNPCQNDASCSVSGNLVLCSCQTGYFGDRCQFLGGTCSPNPCQNGGGCSVAGGVVSCTCAQGYYGNLCQFSAACTSSPCLNGGTCQVQASGYRCMCPMGFIGTRCQTTDGGHIGQCSPNPCENGATCSSSSSGLFTCICPLGFFGHFCQSHQACLSSPCFNGGTCLPEGQGYRCQCPRGYNDSRCQTGSEPLHSCSSNPCQYGGTCEPNGTTSFTCRCTQGFSGIHCENADNPACVILMTQSDNCGGRGQCDTTADNQVNCLCDSPFFGIHCQFNSIGIPQFMVDFFCPNEAAKRATYSGCHAVYRDSTGCSGHGCCSWDSRGGEKCECFRGYGGPYCERFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMP8</accession>
    <name>A0A8B7XMP8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">General transcription factor IIE subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Transcription initiation factor IIE subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC110974615</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Tetramer of two alpha and two beta chains. Interacts with TAF6/TAFII80. Interacts with ATF7IP. Interacts with SND1. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082094.1">
        <property type="nucleotide sequence ID" value="XM_022226402.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082095.1">
        <property type="nucleotide sequence ID" value="XM_022226403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMP8"/>
    <dbReference type="GeneID" id="110974615"/>
    <dbReference type="KEGG" id="aplc:110974615"/>
    <dbReference type="CTD" id="2960"/>
    <dbReference type="OMA" id="ILIRYPC"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000087">
        <property type="entry name" value="General transcription factor IIE subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021600">
        <property type="entry name" value="TFIIE_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11521">
        <property type="entry name" value="TFIIE-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="16">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="293"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="334"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022082094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022082095.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="48183" checksum="002632201631235B" modified="2022-01-19" version="1">MNPSVLSSVTEPSVLTEVPNELKRLARYITRGFYTIEHALIVDILVRNPIVKEDDMADLLKFDKKQLRIFINRLKNDKLIKQTMRVETQPDGRTNRHNYYFINYKVFVDVVKYKLDRMRQKIESKERDSTCKALFKCPQCHKEYNEFDAGNLIDVLTGQLHCTFCGTEVQEDESAVPEKDTYMQIALFNEQMKPIFDLLKSVEHIQLSKTLLEPTPSAANENKKPSAGRSGSASGSGPHSTWSGDSSRNLGFEMYDQQITINVGEETKREQAAKAPARERPVWLVESTVEGAVAETPSGAAQNRSPVGAGPSARPSTKNKESEEIIRALLAHERKSGTGAVVPGEDNSDAESDASGSDDDFPGASTSAPITHTVEMDSGEEDEDEDEEDVMVSVAGRMVPFQDITDELVAQMTPSEKEAYIKIGQEAYAAMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XP43</accession>
    <name>A0A8B7XP43_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC110974526</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110974526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081937.1">
        <property type="nucleotide sequence ID" value="XM_022226245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974526"/>
    <dbReference type="KEGG" id="aplc:110974526"/>
    <dbReference type="OrthoDB" id="6516201at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050906">
        <property type="entry name" value="Notch_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044">
        <property type="entry name" value="NOTCH LIGAND FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044:SF417">
        <property type="entry name" value="WEARY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1356"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="821"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1041"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1206"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1257"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="1308"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="749"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="938"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1425"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1540"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1578"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="941"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="955"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1625"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="841"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1316"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1335"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022081937.1"/>
        </source>
    </evidence>
    <sequence length="1640" mass="178527" checksum="F769430D3C657BF6" modified="2022-01-19" version="1">MAWEEMFQMFPDGFPFGDGTFPSFGPGDADDGDTVPVNEDEETTRPEGEGNEDGPGDEGPVRPGPDGGDNLPPGHGNIRPDTNGRNGSVISTDRDIPWQQLLGQFFEWLEAERDSWPWNMNTGGNEEMMPGTNEDESTRPRPSESDMRPGDDGEVDFENSEESETRSDDHEAEVGPGNEGGEDDEEMAGDHDEETTPGGTGGETSEEAYSPLEGVTQLIGLVSGRNPTSNHTSIGSLPWQQLFDLFPGGVPFADGEISVTQFINVFPRGLPDVGNFTRRVPLSDVLNNRSSERPVQGNSTFPWIGAAQTSLLGVGDRELTWEALYQRLPNGLPIGNEVVPWDALLMLFPNGPPIADDESGDGWTGQVPQNFLNLGDGSVTWEDLFEIYPNGVPAGDYVISWEVLFTIFPNGLPLEDGGTSGEPAVNMPRPMAWTGMIPSEILDLGDGSLTWEQLQQQFPDGIPLGNETITWEVLFMMFPDGPPVASYDWSWLVSGFLLGRPLEDGNGQENPNPGTGAMNGHPWEDLLDVILTWLPSFPDDWSDDGGTPNDNPGNGGIPGVRPPSGGQWSGLIPTGLFDFGNGSETWEQLVEQIPGGLPFDTGNIPWETLFSLFPSGLQPRLEEWPWSLDQMFTGNNGMPPNMGGVSEHTQEQLRPLIQMLLEKLWSGEILIDMIVHFQAGEIPWQDIALIFPNGISFGDITVPWQELIDLFGGDGYGGMSGGSGHEGMMPKPCLRFPFGEFIPRHPYYSSDSGGSSSMSRGDSSSEMESGSGGMMPGSGEAVGMMPGGGEAPGIVPGSGEAGGMMPGNGEAGGMMPGSDGVSNMMPAGKAPTEGDMVYFFCQPGYKLIGSPSITCSCDGTWNGLSPRCKAITKPTVMPDNTTPFAEFTTLDSDDQTSGIFKQELTTINPFKETTSALEEVTMLGEMEFSTTIMVDEVTEDSSEHPNLETDEPKGSMTSPTVQQTDSKTQAKELTTSPNPKLQSTDQPGDPTISPQPKLQTTVQPSDASTSPQQKTQTSLPSNNPTTVPPGESQSTSNIETTNNPCSSNPCAEKANSQCVTTDQGAFACSCLPQFFESDGQCEPSQSFSGTLRITQIDSQPADFTEELQDPSSETFKSMAASMEKTIDSIYLTSSPAIAERYLGSTVLGFKNGSIVVDYIAHLNNTQDESTDDPTVLESAFEEAYMKSTKSGSLNITVDVAASTVTDLDECALSDTNDCSSNATCINLPGSFTCQCHAGFQDVSATPGRPGRSCTVSKPSVCSTSNVECSRNATCYDTDTRPEGYSCQCRIGFADRSPQVILKPGRICEEFCPSSNCFNGGSCVNIYETGEQICSCPDGYTGLRCEEAEQTGLSDTLILVISLTSVASLVIICVGLLLCFTFYHRQTKKNIKRLSLRSYPVKRDLSRFVRDEEVWDPITVETRSQDSRQSLVRESLHQDDYLRPGPSSEPRHLNYPNDIGEDNPDFIEEEFESQSKYIADAMSKLPEVERRMRKEVRSLGNYNFGQEPDYRDNFVRPYMAPEVIPIDQYLQDPRRYKVYDDESRGYGYGRPKRPTIEHHHGNRMSLQQDLRGSRMYLPNDNVAMPTQHDSYPMEDFSSPRQSVHPTAQYPPASRAYLPPSKTAIPLPQPPPPPPLPPVPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ58</accession>
    <name>A0A8B7XQ58_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110974645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022082140.1">
        <property type="nucleotide sequence ID" value="XM_022226448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ58"/>
    <dbReference type="GeneID" id="110974645"/>
    <dbReference type="KEGG" id="aplc:110974645"/>
    <dbReference type="OMA" id="KANMDIN"/>
    <dbReference type="OrthoDB" id="10060767at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="24"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022082140.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="49929" checksum="68456ACADEEDBC31" modified="2022-01-19" version="1">MTSVTLPPSDGGIRKDLPVDRGRAWFVLVGVHVSHMLSFGFLTSFGILYIEWKEYFQTDATTTSWLISLPLLVASPMSFFVGILSSLVGIRVLAMTGAAVCGIATFVGSFTTGVRQLFVCTAMNGVGSAVVLSLGSIVLSHYFKRRYSLATGVAIVGISIGQMIFPVIIRFLITLYGWRGAMFLIGALQMNGVAACALFRPLKANMDINQPHQETLGNSISMLRRRRESTDDEIEMENSCPDESRLNRWRRCAGFLKVFTNVLAMLNLLTLTFFAMSAMINISHLPARTKEAGWSDDRSAMILLVYAVASAFTRLTYGWFVDRGYIGSFKLQLATQFGAAVATFLNPVSDSFAFLVVNALLLGAFLGITAPLFLVNMRQLVDVSELPSALSLIWATGLFFNGVGTVIAGKIYDATGNYVAPFLTGGAIFLVSFMLLVTMTILKTRGNKRCQHPQTVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ61</accession>
    <name>A0A8B7XQ61_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NXPE family member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082959.1">
        <property type="nucleotide sequence ID" value="XM_022227267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ61"/>
    <dbReference type="GeneID" id="110975127"/>
    <dbReference type="KEGG" id="aplc:110975127"/>
    <dbReference type="OMA" id="WDINLAY"/>
    <dbReference type="OrthoDB" id="5950832at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NXPE C-terminal" evidence="1">
        <location>
            <begin position="305"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022082959.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ81</accession>
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            <location evidence="1">Centrosome</location>
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</entry>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665458" evidence="6">
        <location>
            <begin position="32"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="573"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="297"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022082577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022082578.1"/>
        </source>
    </evidence>
    <sequence length="620" mass="68929" checksum="643A2DCC62F624EA" modified="2022-01-19" version="1">MSTSVMSLIPIPTTLWCLALLAFAGLQIATSTSDYKYFFDFIQGNHSCSSSGAVTSPGFPLRHPTSSSHIYFYELEHLSPVGRIKLVFTDFFLDSVNKSFNMCNDKQNYLKIIDDKKSSRYCSFKRPAPLLSSTHSLRLEYHLNGNQRHHGYGVFSLNYFFITLQEAEEFERELKGGNYVQNTAYEVAIIGHISIDILRAQTHWVDYLWYLRGRPGNRLLLNILAVSINPAGMLEVRDGSTSMSPLLLLIQRNSTNVMDVISTQEKVYVHWHGPVSQFNRLRFVYSNVAPMDSSGSCPSAYFKCNNGVCISKERQCDGVNNCQQGGDEDPHACQDQDSADCTCENGGTCMVRENYLICLCPDDFTGERCQYIGRRKHVSAVISRCNCKNGGTCTPTSSGFGFVCNCLPGYGDYDCSLNNSLIQGGASSTEYGIAMGAAVVAVLLVLFGVGLCLCVILQYLKQQREGPDGQYRPALSRDVYSVEAVNIGLNSVEPNDYIPPSYHQCTHHSSHASVATPDGSMDGTLTPTNPSYQRQICRQQRTPESPPPNYDTILKLARDLSPFYRMFTSKGSLNFSETRSQPPSLRDQDSVPNTGSLNTPTTPCNECFEMKHMPDVKEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR89</accession>
    <name>A0A8B7XR89_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110974886</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110974886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022082510.1">
        <property type="nucleotide sequence ID" value="XM_022226818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR89"/>
    <dbReference type="GeneID" id="110974886"/>
    <dbReference type="KEGG" id="aplc:110974886"/>
    <dbReference type="OMA" id="RSAKVWS"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="423"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="9">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="425"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="24"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="393"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022082510.1"/>
        </source>
    </evidence>
    <sequence length="603" mass="65383" checksum="7367F90732CF4365" modified="2022-01-19" version="1">MATTCCTWCVQSPLLKHSIRSILGDSFSGPEGSKAIEKSLTATDSEERKYATGPYEGPPSACVNPPHTASSRPMSQVGNLSTPDEESALNYHGQSAAHRGESDDPAEDGAVSQAESTEGDSAHPSAPAGENQPCKASSVPGVELGLLVDKVPIAHLPGPCRQQPVFLRDFSGWYRHFGPVPLATGGWSSLVHPGHGCVTPAYHSLGLTGRCVRPGGEILIHPEAFIADRRVDFAQTEGIRDSDQSKKMALCSESATRVPSRSPKVPRHSRRPCPKRKATRAPPTGQTPPSSPRSPPLTGTAPRSAKVWSPGKGNDTVGRNVSQPQELRSHEDRQASHGGRPDHHLVEGKTRDESQWKRGVRIDDVKKETSVAGELAPRDDGCLVSKNQRNLEVTARKRGGSDSVRLSSPVSDESPSDEKSPTKRQRRIRTTFTPEQLRELECVFQMTHYPDVQTRDILAAKTCLGEQRIQIWFQNRRAKWRKYERLGNFGGLQDLKITHIVPAPKSLPRIDFAKRDPSVHSFAECSLAGEFSSISGLPTSPFPILQSAAGIAIPAPPIIPSLSPIGPMPGLNPKITGEDRKCSSIASLRLKAQRHGMESVVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTE0</accession>
    <name>A0A8B7XTE0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tubulin epsilon chain-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110975356</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083482.1">
        <property type="nucleotide sequence ID" value="XM_022227790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTE0"/>
    <dbReference type="GeneID" id="110975356"/>
    <dbReference type="KEGG" id="aplc:110975356"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02190">
        <property type="entry name" value="epsilon_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000017">
        <property type="entry name" value="Tubulin epsilon chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004057">
        <property type="entry name" value="Epsilon_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01519">
        <property type="entry name" value="EPSLNTUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="8">
        <location>
            <begin position="287"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022083482.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="50982" checksum="CA97232C6FB4EF0B" modified="2022-01-19" version="1">MTQSIVIQVGQCGNQIGCRFWDLALREHAAHNKKGVYDDSLSSFFLNVDSRYENPHTIAVGDGKSKVRTLKARAVLVDMEEGVVNELLKGSIGELFDHRQLITDVSGCGNNWAVGNKMYGVQYRDQISERVRHAAEQCDCLQCFFLTHSMGGGTGSGVGTSILKLLRDEYPDVYRFVTPVYPSIDDDVITSPYNSVLAMQQLTEYADCVLPVENQALLDICEKINQALPPEKSGKRTFGATGQAKAGTTISGSGKKAANEKPFDQMNNIVANLLLNLTSSSRFEGSLNIDLNEISTNLVPFPRLHYLVASQAPLYSLLDMNLPPRRLDQMFTDAFSRDYQLLKADPKNSMYLACALMCRGNVQISDIRRNIDRLVNGIRRNIDRLRPSLNFIYWNTDGWKTGLCSVPPVGQPYSLLAVANNTCVRHTFSDLRDRFNRLYKRKATFTIIPTWKAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XU27</accession>
    <name>A0A8B7XU27_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110975331</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022083421.1">
        <property type="nucleotide sequence ID" value="XM_022227729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XU27"/>
    <dbReference type="GeneID" id="110975331"/>
    <dbReference type="KEGG" id="aplc:110975331"/>
    <dbReference type="OMA" id="ARYVIMS"/>
    <dbReference type="OrthoDB" id="17569at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000751">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000379">
        <property type="entry name" value="Gamma-aminobutyric acid B receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF78">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034117526" description="Gamma-aminobutyric acid type B receptor subunit 2" evidence="14">
        <location>
            <begin position="26"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="642"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="15">
        <location>
            <begin position="477"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="787"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022083421.1"/>
        </source>
    </evidence>
    <sequence length="818" mass="91722" checksum="68CF2CC7F8AA90DB" modified="2022-01-19" version="1">MERGWVLVRASFVTLLLIWVLSVTADEKNVTDLYVLTLFPMSGSWAGGQGQRPAVEMGLRHVNSNPALLPGYRLVMVPEKAEEADTQCNGGKGTDVMYRELYNQTTTKIMVLGAGCSIVTQPTAQASHHWNLIQLSYSSASPLLSNRNLFPKFFRAFPPETVFNAVKFAMLKHFGWKRVATLHQTIDLFSLPTVAFLDQAKENGIEIITSESFADNPDIQVSNLKKQGARIIIGNFYETKARQVFCKAYKEGMCGKKYVWIITGWYSHQWWLGEHEDSKHDCTKEEMSEAVRGYFTTDALPLSLANAPGVAGITTAQFLEEYREYVSGHPEKLSGYQEAPYGFDSVWTIALALQEAEARLQKFDPPRTIADFSYEDEEMANLFFEIMNATNFEGVSGPVQFTFDGDRKGLMQVEQQQDETEVRVGIYHPSSLEENKLEWTNDPPIVWQGGKPPADSIQEKEIPQTISHGLFIGVSTLATAGILLALGFLAFNVRFRKRRFIKMSSPKINNLILVGGILIYVSIYFNGLDTSRVHFDSYVSMCKANTWCLGIGFAMAFGAMFSKTWRVHKIFTSKAMMKTIIKDYQLYVMVAVLVLIITLVLIIWEVVDPLQIVERKGAREQTDDLDVVIIPVHVTCESTWQVYWVGTLICIDGLLLIFGAFLAWETRKVTVPALNDSKYIGMSVYNTVILSFTVVPVSLILDEVDARYAIVSFFTLFATTLTLCLVFVPKVRARNEIHPKGTMLSTMKSGEEGESDSDRRIRMLSEMIQRLQTSLVKKDDIIKELETAGISGQSRQHGESADEGTNTDGTSHEDPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV47</accession>
    <name>A0A8B7XV47_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane 7 superfamily member 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022083761.1">
        <property type="nucleotide sequence ID" value="XM_022228069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XV47"/>
    <dbReference type="GeneID" id="110975521"/>
    <dbReference type="KEGG" id="aplc:110975521"/>
    <dbReference type="CTD" id="51768"/>
    <dbReference type="OMA" id="NVKPATC"/>
    <dbReference type="OrthoDB" id="5967337at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043069">
        <property type="term" value="P:negative regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042502">
        <property type="entry name" value="TM7SF3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15937">
        <property type="entry name" value="TRANSMEMBRANE 7 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15937:SF3">
        <property type="entry name" value="TRANSMEMBRANE 7 SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25992">
        <property type="entry name" value="Ig_TM7SF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034356524" evidence="6">
        <location>
            <begin position="24"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="307"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022083761.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="49243" checksum="F9C003A5D655BD0C" modified="2022-01-19" version="1">MKVYHFSEFVFLLLIQVSTEVALHDECINGLDGRLHLNLLIPTQCNLPPLAKLHIQLDHVDPSTSFLILTVQTPNIPVQISLTQNPTLDYSINGTDVGLVSVLEPGQELVQWFLTSSWNFTVPVQLFALPYQSSNTSLVPIPGACNQEFDLENDPNLHLHNTSSLNITVLEFAAANVGMKRGSIPSSCDSGTTSLRFRLTYALYVRHLGAQEFDNETFFDEMMKMSRVGDIRKYGEQIQTFKKEDITEFYQVNYRSRGFIYNVIVTDPTFGTEAAYVPAVVYSCELQDNSLACKDDVDFGVILIATFTGLAGLVICLFGHRIFSYEIFFVGFVPFFIGAFMVFGSQVPMSPFALSAIAGAFGLLGGAVHFALWWRFGKYLWSMLLAGLNLGFLLSALVFFVSPLENLSTFHNNALFGLTFSCGMLIVPVVLLYFPKVVRNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW19</accession>
    <name>A0A8B7XW19_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC110975876</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022084422.1">
        <property type="nucleotide sequence ID" value="XM_022228730.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084431.1">
        <property type="nucleotide sequence ID" value="XM_022228739.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084442.1">
        <property type="nucleotide sequence ID" value="XM_022228750.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975876"/>
    <dbReference type="KEGG" id="aplc:110975876"/>
    <dbReference type="CTD" id="9700"/>
    <dbReference type="OMA" id="VESTAKC"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="6">
        <location>
            <begin position="2250"/>
            <end position="2345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1160"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1302"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1541"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1718"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1302"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1553"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1582"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1594"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1638"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1719"/>
            <end position="1756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1784"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1803"/>
            <end position="1812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022084422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022084431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022084442.1"/>
        </source>
    </evidence>
    <sequence length="2427" mass="268945" checksum="745316F381DB2D6E" modified="2022-01-19" version="1">MEGERLLQRIKTSTDVEPVLRDLEVYLAPVLRHKTSPSQEQAAKYGFYAMKVLRACVQQLSALKTGNGTVAGIICIARRSYECVCKVLKHTKLVPLSLEKLLFHMVVQGMAKGLVVDATAFATNLHERLGLCRNNFITGDGVDNEYDTVCKQAFNQLWKACVDLEHSSKQGAMKHVVVLDVRLQALNFLMLTSYEVSWVVERAFRTIVEFDRASSNSMEENNQVLEFLRHILKSLLSDLRDARKKQDLQSEEASELLPPLFELSLLFAKRCSHLKRPEEAMSLCKQLQEIITSNCRKHCKKLYSAAVSTIGVTLEMRNFPSPHVCRNTKKSKSHKAGDAIKTAEEQIEDVVGSTSKVIEKGDHDIAAIQCLVEALEFFKKQFECIVDQQGRSPNPSKVVIPQDLVHSVDAALKLLVDLLQVQREQLQSSSGTLHESSAGKGKQQRMSLQKTVNRQLATLNLMAAILQDRMGRQEEGATSADIRQMTQDALGICQRTQCIIEEVSSGAGGALSNNEHRWLGTNAYNLGLMCYRKKWYPDAVPLLIMACEQLQIWCATKEQVDEEKVHKVQLFSKHELLVDCQRKAGQHKEAMQTAVTYLWAHAGHLTDQLTTAVEYWVKAKRDTAKNAEDERLRTRTLLDAIQEIEGTISDESSSLVSKLLEQELSIYKAQRYDTTVEQYAVVCDLLSLYSEDRMRLHRAHARIEQAQLLRDGTLDTDCSPVDCCQEAIHLLEELAQDIVQQQQDQEASSADYLVVFDLLATAHFWLYICQSEASQATYITSQFANTKGESTRADCPEPATIKKDKASSYLLSTSGYTLATEHSATEPLDRALDIWMDLVAEGCSQSMFNDPACTSYCLKVAASLCELADRPIQQVQALNLLVVLSISTSSNEDTVLAYCQIIQALCRMGAVEEATALLAPAQALMGEAETEGEDGAGLQVAFTIAKCYVVLAAHKTGEFETLLEKVLQIHSHKRRSRQAYLRNASIKHLQALYLLRPPSERSQDASVLRGLVPDDLSPLELQAEAMRLQMGVGRLMFGEGVFGNEQSLQGEGFKLAAVGNDSGGNDLEFNQWTVLANVLRSLYDVGSLYLEQGCTREAKSYLKEGLLLADKFMLPRRSVAFLLQLSNLHVQCGQEDDCQASLSKVQQILHLPEKAAQARWRGASMVTQDERKSSSGSETHEETDDDNFIRTKRISISAECSSTTWRLEDTDTSSSPWLKAQTVKLPSYHSHPSDCLCASCADVSLHAQDMTSFLRLAQRLELQGEPTQALANLRVALDIGDWSATKTPSLLLRSSSCLHNDEGVKQTKGPEMKLARPSRSSGGQVNLHARATTEIHVCITRLTLLNGNLSEAEHTIAGGLELSIDENIPKAWLHFYRILVSLELKARATETTVGDLTFSTWDLQPSSRHHKDVPSYEGDLVSQFHQLDLGKQGTKHQTQFQDMVFSERMQRPEVSRKLSEKVTELGIFCDVSDNEDDSDGISHMPACSTKSSRKLQQLVQATPHNVASRSKKGALMFSVKKKRPAKKTVEVEATPLHSAPLSAFDFDEPSPTKTKRKATRGRSSKSAKKISKRSTEIIDLCNSDDGDVFEDETENKGRKTATESKRQTAKKSVRLNLDAETFSNPLENEDLMGEGATSKPSQKSIQPTQVGDTETKPRRGRKPRAADTELAEPKVTATRSKRGRKPNVENLRSEVVNQVSNNMLLDLLPTFLELESPTKVHSLSPGSPNHGSLNFDFESSPSTRDIPTPDSLSERTSLALPDLDEIEIPRAASDSDESRSALNVRRKTARKPATSRRKTAKKWTVEDTEVPRGAKNAPVDALSTRRRPQQQAVIADQDGIAQTGLSNLDTSLDSVIAGLEQISAQVCHRAPSLLYRRVCQLLAACHGDREPMKAAYYLSEAAAVTLRHQKLASLAKKMKKLKKELDADGVQNLTESLAEMALDGRSKASTPHGATLQHLAKQRALFNFCEGSVGDAQPDVVQQTLTALPEGWTVCILSVVSSSVSLTGSLTDADHLVMCRLSSGHKPVIINQAMHTGGLGLSATSLLAEFDSILAESKLSVKETDKRAWWTCRQQLDQRMQALTEAMEETFLGQWKGLLIGARKCKEERQAMDKAAKKFKSLVESACQRTVDSQMCQCLLESCLKLSKLQLSSALASLTGLSPGSEQHSSLTASVKQLAEKLAPTPRREPVILILDKQIQQLPWETTPILRESPVCRMPSLYFILSWLRRASGTQLTSPTCLSTPPPIDPSDAFYVLNPSNDLANTQKTFQKWFEKENGWKGVVARPPTKEEYRSALTDHQLFVFCGHGNGREFLTGDDIQRLTCRATSLLIGCSSGRLHVTGTQEANGMVLNYLVAECPCLVANLWDVTDRDIDRFLEQLLRSWLDGGGSLLDGMAEARQACKLQHLIGCSPVVYGLPVCMQEGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXQ1</accession>
    <name>A0A8B7XXQ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110976580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022085664.1">
        <property type="nucleotide sequence ID" value="XM_022229972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXQ1"/>
    <dbReference type="GeneID" id="110976580"/>
    <dbReference type="KEGG" id="aplc:110976580"/>
    <dbReference type="CTD" id="79676"/>
    <dbReference type="OMA" id="HCHEAMA"/>
    <dbReference type="OrthoDB" id="1736837at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24014:SF4">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25238">
        <property type="entry name" value="OGFOD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022085664.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="24576" checksum="DFABDC2AEEE3AF08" modified="2022-01-19" version="1">MWQDLWKSYIKKMFCQDFIQEICHFESTDLPKGRPNTMNNYGVLLNELGFNAQFVTPLVQDYVTPVTRLLYPECGGTSLDSHKAFVVKYKVGEDLSLAYHYDNAEVTLNVSLGKEFTEGSLYFGNMRWVPLHETACSEYMHKPTFALLHRGQHMHGALPISSGERYNLIIWMRSSQVRNKRCPMCDQRPELVETVGFGDGFTQEKETVNVCATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0G6</accession>
    <name>A0A8B7Y0G6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Two pore calcium channel protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110976753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022086007.1">
        <property type="nucleotide sequence ID" value="XM_022230315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0G6"/>
    <dbReference type="GeneID" id="110976753"/>
    <dbReference type="KEGG" id="aplc:110976753"/>
    <dbReference type="OMA" id="EVVFDMY"/>
    <dbReference type="OrthoDB" id="10068803at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726">
        <property type="entry name" value="TWO PORE CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46726:SF1">
        <property type="entry name" value="TWO-PORE CALCIUM CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="677"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="796"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="796"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022086007.1"/>
        </source>
    </evidence>
    <sequence length="825" mass="96224" checksum="5BDEFC3997459FAC" modified="2022-01-19" version="1">MDNHVHSYKPSLKIKAKDAELMRERTESIVRPRSVSFIKTEEGEMVTIDLFNQPTAEERTEETLVNESDLYLAATYIIDAKHSRNYKFMTDPKSLKNYHLYNNTFMQLVLYLFIFLDLALALFEEPAVETLGMPYWSTQLLELACIAYFIFRMVHHRSFTPRKIWWTDAKNIILVIAITIMCVDMIIATILVEARVTEKVFRWSRLLRPLFVVNFPEMREIRRSFRNIRRSLPEILAVLVLLFLFLFLFALLGRELFADDQLEKVLSSEKYFVNYFENIWELYILVTTANSPDVMMPAYDASGFYMIFFVVFVLLCNYIFMSIFLAVIYKNYRKHLKNEVQTSVFLKRRKLAKAWDILRVTHDGKFVLTWERWQAVMSYVIPKYSPMKVKLLWKVLDEDDDGYVEKREFLRIVDLLNVKLSTVNASTPFFQKYVPSCYSSKVSEFICKCVKHKSFRYFFDVVIVANAMLIIAELDQAEWFFLALFIVEILLKMYVFGFYKYFHNFWNIFDFVIVSTALIITVIEEISKVTPIDYSGKALDFILSLRVMRMLRVIQSIERYQVIISTITNIGPSILTFGGVLFVIFYVFAIVGMGAFHDLIQYHGYPNEGSNIDANRLYCGTNLTNFTKSEFYNHHYCNNNFNNIIKAFIVLFELMIVNQWHVIASGFVLVTNKGARVFFIFFHILMVVIVVNIFIAFILEVFMVEYSLSKNKTEGAIEKKIDELGLGVDLTEENQNRASKPVKIDKLNLTSDMEGQNSNAADKKPTDPGIRFRIGKKSRNVQVSLQAMFEGELDEENMGPETLDDMDELDPDENEPVAYTLNNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0W8</accession>
    <name>A0A8B7Y0W8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Dehydrogenase/reductase SDR family member 7-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8 9" type="primary">LOC110976723</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085931.1">
        <property type="nucleotide sequence ID" value="XM_022230239.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085932.1">
        <property type="nucleotide sequence ID" value="XM_022230240.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085934.1">
        <property type="nucleotide sequence ID" value="XM_022230242.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085935.1">
        <property type="nucleotide sequence ID" value="XM_022230243.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085936.1">
        <property type="nucleotide sequence ID" value="XM_022230244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0W8"/>
    <dbReference type="GeneID" id="110976723"/>
    <dbReference type="KEGG" id="aplc:110976723"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053011">
        <property type="entry name" value="SDR_family_member_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022085932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022085935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022085936.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38327" checksum="918AFB6545848B2F" modified="2022-01-19" version="1">METRTAIVFTIASVIVLFSLPILHFLAFGVMIFFIVNVTMAFTHDGDLLLMLYEKWGQDGSNLKGKVAWITGASSGIGEALSYELAQKGVKLILSSRREQELEQVRERCLQFSELTDNDVLVLPMDLRNYESHKGCADKVLSHFKKVDILVNNAGRSQRAFAADTSLEVDKALMDLNIIGQLSVTKAILPHMTARKEGHIVNISSVVGRVPGELSCTYSASKHAMLGYFGAFAYENKDISITNVCPGPVKSEIVINAFGNKLDAPKFKDDHSAAERGPSFCMTAERCASLIVIAVANKLSEVWICKNLAMFLMLMYQWAPLLTVWIKKKVYGDERVESFKKSQMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y384</accession>
    <name>A0A8B7Y384_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110977655</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110977655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087644.1">
        <property type="nucleotide sequence ID" value="XM_022231952.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087645.1">
        <property type="nucleotide sequence ID" value="XM_022231953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y384"/>
    <dbReference type="GeneID" id="110977655"/>
    <dbReference type="KEGG" id="aplc:110977655"/>
    <dbReference type="OMA" id="CASEGWD"/>
    <dbReference type="OrthoDB" id="354351at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022087645.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14321" checksum="D4CD4893F32C6FDA" modified="2022-01-19" version="1">MPANFSGKWVSCASEGWDKLLGKFGVPLDKFPTDIQVTEEINQSGDTINIKATNNKDDKVKQTTINVGQNFKDTIAGVKELEFTTAWQGDKLVLTKIDNKGSVTRELSGDNMIVCLNHEEVVAKSTFKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4W5</accession>
    <name>A0A8B7Y4W5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F-box/WD repeat-containing protein 11-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088234.1">
        <property type="nucleotide sequence ID" value="XM_022232542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4W5"/>
    <dbReference type="GeneID" id="110977971"/>
    <dbReference type="KEGG" id="aplc:110977971"/>
    <dbReference type="OMA" id="CHEYWEN"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042627">
        <property type="entry name" value="FBXW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44436:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022088234.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="64517" checksum="83F38A4E7D8E54AD" modified="2022-01-19" version="1">MESSSLSGNLVALPTELHHVILQYLSARDLCHMALCNRSWRDVANQDALWRPLCRRRRWERFGTTEDLCKEVSTALPAGNTSVAFPIEMVVTDSDSSTLIQTCKWKEVYMRAQHLEANWINNCCHTVSFEFGAAGCHEYWENPAESELLDPNKTEGLVVAALDAEGACLAGSLSNNTLKIWDMSTGDCQHTITLDGFSSGSPNSLMVKSGIVAVGCWDGRVRTFSAQTGEKQRVLGNFYREVTHVLFDGEIIVSTAHPENDRYTYDDSGDEEESKGEDGDDDDGGDEEGGDSGADGSVGGDIRAYLTRWGEPRTSDMIEKVGNEIKVFGSEDTSNFRLRYGSGRSPLIHVDYRDKIVAAAYEAKIICLWDAQSGSRQHTINTGLNCLVSCHLGDGIVIGTNKTNEPVMKMWKLSSGQLIEAFDCPSVRFFDKANEISKVCGRMLYHFDPNNAFIVGRSKYGMLGMFGLDGSYYGDTKSFKVADDFEDHLRLIVPCLHGNKIIGGECCDGRMFLFILSSAGGFKLVREVRPMMQELFAGLDNVNPLHAWMSTTKLVFVSYFRYEEKEEIQVPKIVIHHYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y573</accession>
    <name>A0A8B7Y573_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110978027</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088349.1">
        <property type="nucleotide sequence ID" value="XM_022232657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y573"/>
    <dbReference type="GeneID" id="110978027"/>
    <dbReference type="KEGG" id="aplc:110978027"/>
    <dbReference type="OMA" id="SANTIQC"/>
    <dbReference type="OrthoDB" id="10434693at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088349.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="18501" checksum="DD6F93C293FF9392" modified="2022-01-19" version="1">MAKKNRSRTPVNKASLDPAPMAEPAVGDLPDAASENASEPCMPEAAKEVPGMSSTALSADETLEASCTEDKPTVTDDSDSNDTVELKEDEATSGDQAKGGSQASIPEEAEKSLDHDTQELDEEGGLPQNKPQVEEVQDQERKRPLEGAENDEGSAAKKVMSEVSANTPGKTVGCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5U3</accession>
    <name>A0A8B7Y5U3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein PET100 homolog, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110977406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087196.1">
        <property type="nucleotide sequence ID" value="XM_022231504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5U3"/>
    <dbReference type="GeneID" id="110977406"/>
    <dbReference type="KEGG" id="aplc:110977406"/>
    <dbReference type="OMA" id="MALYMTF"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022087196.1"/>
        </source>
    </evidence>
    <sequence length="90" mass="10862" checksum="AA740E507CEA5E01" modified="2022-01-19" version="1">MGGWKLETARMGIYVFFPVVMFYCFNRTELFERYVTERIKLLYPPESKMHKKEFDELRNRMEERVAAKQRKQEEESLRLMEAARASQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y652</accession>
    <name>A0A8B7Y652_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein 18-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110977738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087825.1">
        <property type="nucleotide sequence ID" value="XM_022232133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y652"/>
    <dbReference type="GeneID" id="110977738"/>
    <dbReference type="KEGG" id="aplc:110977738"/>
    <dbReference type="CTD" id="57418"/>
    <dbReference type="OMA" id="GVNARIY"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056828">
        <property type="entry name" value="Beta-prop_TEP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25048">
        <property type="entry name" value="Beta-prop_TEP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="117"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="TEP-1 C-terminal beta-propeller" evidence="5">
        <location>
            <begin position="187"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022087825.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="47404" checksum="D47BD1F91DFDB4EB" modified="2022-01-19" version="1">MAAPVEVMLSTDVSGMLWNVCIWDFHSGTALQTYKGGCSGPRSLCCLSGQFLISAALSKPIIYVWALQKKELQQQRIVCPGVVSCLAASPDSTLCVAGIAEKIHMWQTCSGDQLAVLSHHYQRVTCMCFTDDGSHLITGAEDNLVIVWYTASILQQVSNLKPCEPLFVWSKHALPITDVHCGIGGSRSRVISASHDQTCKLWDLATGELLCNFVFDAPVCSVAMDTAEYHLFAGCADGNIYQVNLFASNVQMEKHISKEEPEEMDSSVFKGHSKPVTCLSVSMDGTLLVSGSQDNTACIWHINSKQQIRTLNHKGAVSNVKFTPSPGNLVNSQSKPTFPLQTFKRHLLSAEADGDEKSGGEIGVRLQDQVSTDEDEDRNKEHMLIQAAVQQQQSSTKKPNEPSRQQLEQELEKLKQTNRLLFKTAAEMVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y696</accession>
    <name>A0A8B7Y696_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histone H3, embryonic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110977866</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088067.1">
        <property type="nucleotide sequence ID" value="XM_022232375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y696"/>
    <dbReference type="GeneID" id="110977866"/>
    <dbReference type="KEGG" id="aplc:110977866"/>
    <dbReference type="OMA" id="QSTMART"/>
    <dbReference type="OrthoDB" id="9929128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
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</entry>
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        <location>
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        </location>
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    </evidence>
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    <sequence length="504" mass="56081" checksum="0F7BCF560428CA25" modified="2022-01-19" version="1">MEGQPSSNSSSQQATDSRTMLSQVTPLGSHPSPFPASSTAPFFSSRRDHEPAFAVATANFDKPNLRSSQLLQGLSRLEGAHGHVPGMGAFHPVHPQSGQRSSEMNGGNHMTSMANGSHSFTDQHRSIEDTSEDKRLPRRKRKASNHEFSVCTICGVTVRPVELPAHYEIEIDRLNKITRPGKSSRESSSHSKKALPSTSSAKRKRENEEEGLVNKDSRREEYMRVKRNRLERLNARLGRCRKGLKKPLEETPSSAALCPICHEVLTGSVEERNTHAEACLRKVNPSQEDVEEEVNVDGEDDDFEEYTWCGQTRVRATSMLDSRFREAGFEVGRKEAECDTELNVDDDDTAEYGPEQFTEVDIIPCPSDDSAEDKQRQALRDAVVGSDERASPPGSAPDPWLPSTSHVPSDTKPHRTEGIASARSDTVVECLKARIQELQEQLDSAAAVRIKCLICMEPFSVPLVSIQCWHVHCQQCWLRTLGAKKLCPQCNMITSPGQLRRIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7X2</accession>
    <name>A0A8B7Y7X2_ACAPL</name>
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        <submittedName>
            <fullName evidence="14">DNA annealing helicase and endonuclease ZRANB3-like isoform X1</fullName>
        </submittedName>
    </protein>
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        <name evidence="14" type="primary">LOC110978078</name>
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        <lineage>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HNH"/>
    </dbReference>
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        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF3">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="42"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="329"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="713"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="954"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="532"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1011"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1180"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="679"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1195"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022088440.1"/>
        </source>
    </evidence>
    <sequence length="1411" mass="159212" checksum="7E6D0503BA2536BB" modified="2022-01-19" version="1">MNMMNESVAPINDDQRTMDAQLDFLPRNLRDSLLHFQKEGILYALQRKGRCLFGDEMGLGKTIQAISVAYYYKAEWPLLIVVPSSMRYPWIEELERWLPDLQPRDMNLIMSGSDVRNIARCKVSLVGYGLLRNDSKTLVQALTDQAFRVVIVDESHYMKNRKAARTKVLVPLLQAAKRVMLLTGTPALARPAELFTQIDSVQKGLMGSFSQFAKRYCNAHWRQLGRQRMWDTSGASNLDELHKQLVKSVMIRREKKQVLTQLPPKRRQKVPFELADSDEKKELEKCWTELDKIINPASDPMEEIHNTGFEVKKLATQMYTLTGKAKIGAVCEYVKMLLENQGLKFLVFAHHKEVLTALAQTVAAYAKEHKMPLKYIRIDGDVPSSERMQLVHQFQNDSNTRVALLSILAAGTGLTLTAASQVVFAELHWTPGILEQCEDRAHRIGQQNAIHVHYLVARGTIDEWLWSALSRKVNVLSNTLNGRVQHLRMEEKGGDEVAFLKHAAAWLPSNRDLQDDESFYFASKKTSHDIRTFFTPGHTESTKKRKRDHLSSSRPAETPPNPHRVESISIDEDDDDFRGIKKHRPSSDLSPKELFAADAQLSNKTFCMMPGPGKFEKSTTVDKSTATGKDSGLAHFVDDLPEMRSNKKRRGNQRGKTELAVVEFEKNRLSDSDTEMDDQTTSSRNSNQSSREQCMPSSFEDKEKQNTVKELDANDSWSCCACTFENHADLPFCEICSTPRKTTRCRSSKSARRNLCTERASGQCGSIKKERASQSKNYSPTTRRHTTLDMLNQESSSIRLTDLDKSAVCNSVTKSPSLVENTSHALDGDTDSDNSVSSDSEATVFYDFHREPDCISSDTRGEQSSKKESTVKCFKPKEEAVGDCNLAEELKSSSSDTAVGSESSTTRENWTCDDRYCRHINSAYDDQCEVCYKTRPASKPSRKDVCLDAESSAAEENWTCDDPFCGYLNSASDDQCEACWSPRPKELSDARSVSNTQLPGFIRASQMNLVQSPGNKDDASVPEPEQGWPYNNRDEGDTGTDSSQTEPEEEPVLYDSFLYCPSKHTDRIYLYDQDGNALNCSFQAIDLQHRDLDALPKILHSQHNMHISLRFLKEWNSLNDVKRKQLRKMGELFDRPLAALEALKQGQHYQPCTKRFITKVDLAEAARQKAQSLGGSLRVISRPATKTAKRRAHNRHGDQSLADGEKSHQGLKSSVEQEKRSWWSDDNGASVKRGTYIQAVDGEGRPLCVFCGNVTAPSTTAHQGAAWDMRYCSEKCKDEHSLRWKNTKYVRQQLLEAEHGICQICGLEAQQLCNIIKDAAKGERKELLQGSPLSKLSKQRLNDIIRNPSSGQFWHADHIVAVHQGGGLCSLDNYRTLCVLCHDEVTAKQNTKRRNRDRAAGIPDIRSFFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8U8</accession>
    <name>A0A8B7Y8U8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Pleckstrin homology domain-containing family B member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110977931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088166.1">
        <property type="nucleotide sequence ID" value="XM_022232474.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088167.1">
        <property type="nucleotide sequence ID" value="XM_022232475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8U8"/>
    <dbReference type="GeneID" id="110977931"/>
    <dbReference type="KEGG" id="aplc:110977931"/>
    <dbReference type="OMA" id="YIGSEVM"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000073">
        <property type="entry name" value="Pleckstrin homology domain-containing family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039680">
        <property type="entry name" value="PLEKHB1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309:SF10">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022088166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022088167.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26410" checksum="89FC7534BFA21086" modified="2022-01-19" version="1">MASLEAARAQGVAKASWMLRRSDILCRWKHCFCVLFRNGRLTYYKDETRKEEQGTVKITISCYLINVGAEVKDASPPPGKDISCLLELRTHEANLLFCTDSVDDSQAWKAAIVEVKNSTAHPAQPPAVAPPQALAPPPVMAPPPYTPQPAPVVAVAPPPYTVTQVATPANHVVVNPVGGATTYTTYQVPANQYVIPPANQTVIVNGRRVVRSYPVQSTVYAYPGQTCMYTCQPSQTTVVYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAJ8</accession>
    <name>A0A8B7YAJ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110978217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110978217</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088725.1">
        <property type="nucleotide sequence ID" value="XM_022233033.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088726.1">
        <property type="nucleotide sequence ID" value="XM_022233034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAJ8"/>
    <dbReference type="GeneID" id="110978217"/>
    <dbReference type="KEGG" id="aplc:110978217"/>
    <dbReference type="OMA" id="CLGVFHI"/>
    <dbReference type="OrthoDB" id="10377351at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF165">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022088725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022088726.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="28377" checksum="9F899EE13F9D6E13" modified="2022-01-19" version="1">MATNYNYSPGCGVCLGVFHILFGLGSCACGVAAIVLHAYVAEIAVGIWAGVVFYAITGILALASSTRNNSVITAYYVMALLSVFVSMGQMGLYVWAVINEVWTCFDSLYWQFNGSCTETQIRDLIMHAILLLLAFLEWIIAMVSCCTACTCCFNNDVAPTQTVVIHSMQQPVLQPLPTQGGPAVVMPPPQAEYVGSYSGGGVPTNIAAPPAPGYSEKPQLPPYPAAGDPLVYHNPTFDQAMPSGDISALPHPPQAQTQAHNNATYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YB54</accession>
    <name>A0A8B7YB54_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ectonucleotide pyrophosphatase/phosphodiesterase family member 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089792.1">
        <property type="nucleotide sequence ID" value="XM_022234100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YB54"/>
    <dbReference type="GeneID" id="110978815"/>
    <dbReference type="KEGG" id="aplc:110978815"/>
    <dbReference type="OMA" id="GYMDIGW"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF126">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034844001" evidence="1">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089792.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="48947" checksum="C89C730763D9E2BF" modified="2022-01-19" version="1">MVLVSLICVVSLAFATQPVLAKEKLLFLLVDGFRWDRLGYDMPALDRLERQGVRAEWLDGVFITRSAPSMFSIATGLYIEHHGVVHNIAFDPVTGERTNGWSEMLNTTWWFNWAGEPLWITAKSQGLKVGSFMYPGGQTPIDGILPDRFVPYTSETYHKYVNLVDRADVVFEWLYGDGLDVVFLYVGKLDSMLHAAGIGEEAGKVADEVNELVSYILDKMEETGVRENLNFIVASDHGMVNISNNKALSMFEYIDESLLDFVIADGGSVFQILPVDGALEQVYSKLKSAHPSINMYKKEEFPPWFHYADNPRNLPLIGYMDIGWTMYKQVNQSEVTDKAGHGYDNRDMTMKSSFYAQGPSFRKGYRARHFESVNIYPLMCELLDIVPAPNNGSRDNYKDMLVSEHPPTSPPGCGVSALCSHTTLILLTVALSASTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBS9</accession>
    <name>A0A8B7YBS9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoamyl acetate-hydrolyzing esterase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110979310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Probable lipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090693.1">
        <property type="nucleotide sequence ID" value="XM_022235001.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090694.1">
        <property type="nucleotide sequence ID" value="XM_022235002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBS9"/>
    <dbReference type="GeneID" id="110979310"/>
    <dbReference type="KEGG" id="aplc:110979310"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000002">
        <property type="entry name" value="isoamyl acetate-hydrolyzing esterase 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665544" description="Isoamyl acetate-hydrolyzing esterase 1 homolog" evidence="5">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022090693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022090694.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="29403" checksum="26F0BC8C15844C6D" modified="2022-01-19" version="1">MTVTLLFLSRFIVHYYLISFLSGRQFSFSQGGWGAAVADALQRKCDVLNRGFSGYNTSWARFILRQCFPGEMLTGVALVTLFFGANDASLKEVNRIQHVTLDDYRTNMKAILQYFIDGGLQANQVILITPPPLGEEKWAVACMEKYGSPINRSNANTGLYAKACCSVAQEFGTGLLDLWTSMQEDKHWLRFFNDGLHLSQDGSTFVAERLVKIVKERTSTCPRCFRTGRTLTLPAQKRASCSETFMGERLGMIPSKVVACSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBU7</accession>
    <name>A0A8B7YBU7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Partner of Y14 and mago-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110979329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pym family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090724.1">
        <property type="nucleotide sequence ID" value="XM_022235032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBU7"/>
    <dbReference type="GeneID" id="110979329"/>
    <dbReference type="KEGG" id="aplc:110979329"/>
    <dbReference type="CTD" id="84305"/>
    <dbReference type="OMA" id="IPGCADS"/>
    <dbReference type="OrthoDB" id="21625at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WIBG Mago-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="155"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022090724.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22753" checksum="94D099962D2D7B15" modified="2022-01-19" version="1">MASSVHTITDETGTYIPASQRPDGTWRKARRVKEGYVPQEEVPVFESRGRKWLNSRPTMPPGMHHDPDPPPEAKPEPETRSMSKSAKKKEKRKQKKQERAADDSGRSVHEPPDDISQKLADVSLSPALTAGDTDAATQRTGRAPSAPPDKRAKTLRKKLRQMEELQAKIDSGELASPSKDQLEKLARRAEVEEELEKLIAEFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCH6</accession>
    <name>A0A8B7YCH6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110978583</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089386.1">
        <property type="nucleotide sequence ID" value="XM_022233694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCH6"/>
    <dbReference type="GeneID" id="110978583"/>
    <dbReference type="KEGG" id="aplc:110978583"/>
    <dbReference type="OMA" id="WEGLCEM"/>
    <dbReference type="OrthoDB" id="5966951at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022089386.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47247" checksum="154A55B8740B9931" modified="2022-01-19" version="1">MSIMSQTDGSEVILKEGLCIKKSGNRNLLGQYKWQKRWFVLIQRGRTATLYYYDKQGAKTPKGQIQLSNKYVTREPEGKEREQPNCFEVGPFAEDGTTRTYYISCESEDDKHEWMEVLDAAIEGASAQKALLRKQTASFKAKKRKDRESRNSQLAEKNEFRRDMYLDAEWRKQQWNNLLALAVGKNWKKTDTKDGVTVSRMSFSDLPLAVVKVEGVINARCRHVYSFIQRAIRPGGKLDFPFRGADDVLEEFTIPPRGTIMDCYKEIKVLPNTSPRRMTLLQMFVPLQLTQGESCGILITSVHHPDSQKKQGAVSCNMGLSGCIIKPQQNPQASLSTNPPPDTEEDSASEDEDGLLPPCRAGRSEVTHLTLLGQINLQGSLQPMLKGAYKSGLLVHGMRAFFQNLTEHIYSYVKIVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCL4</accession>
    <name>A0A8B7YCL4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110978606</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089421.1">
        <property type="nucleotide sequence ID" value="XM_022233729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCL4"/>
    <dbReference type="GeneID" id="110978606"/>
    <dbReference type="KEGG" id="aplc:110978606"/>
    <dbReference type="OMA" id="YTWLLLM"/>
    <dbReference type="OrthoDB" id="5586934at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802">
        <property type="entry name" value="SI:CH211-161H7.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802:SF1">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089421.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35143" checksum="C5A6001F803BD68D" modified="2022-01-19" version="1">MDPEGAKKHDVLFICMSVLFTAALILTLVINAFSTTIGIEIGWFLNITGDISDKYYMEITPAGWTFSIWAVIYVFEGLFALYLLISLFRRNDQGPVYRNPPVINSLMLLFYTLNLGINVSWLFVWDRELMPVAVALLALLPFTLYLVLIINHRLVDQSGINLRNNHRIDLIAVRIIIQNGLATYATWVTIATLINFAIVLRYWGGMSQSDASTVSLSILLVEVLVYFVLENIVFEKYLRYTYTVWMVAIFALSGSIAGNWSIGSRNSIFSVVLLALAGALFIVKIALSIGRSYTRPLYVNQVSESKEELELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDN5</accession>
    <name>A0A8B7YDN5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 17 member 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110979667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091373.1">
        <property type="nucleotide sequence ID" value="XM_022235681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDN5"/>
    <dbReference type="GeneID" id="110979667"/>
    <dbReference type="KEGG" id="aplc:110979667"/>
    <dbReference type="CTD" id="63910"/>
    <dbReference type="OMA" id="LITFWMP"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015291">
        <property type="term" value="F:secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000059">
        <property type="entry name" value="Solute carrier family 17 member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF279">
        <property type="entry name" value="VOLTAGE-GATED PURINE NUCLEOTIDE UNIPORTER SLC17A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022091373.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="50124" checksum="5AF7D137E4F0276E" modified="2022-01-19" version="1">MLKSKSAPSLHPSKFVKIRLKSDDGPDSGLWTRHERIEWTVILLVGSTILYSARTILPLCAVSVAREFGWDKAETGLVLACFLWGYPFTQIPGGYLSDKIGGDLVLYRAALIWGVVTIITADVPYFYSSKAATVFSMAFVRFLLGITQGVHYPSMTSLISKKVSVDDKPSVISVIFAASSTGTLFTGAVGSVMLLYFHWQSVFYFVGVLGIAWGLGVRWFIRKRRKKTVYMLQNGRQDESVIKIQTAEQGETAQGCAHFPWKELITKKPFWAVLVGHSCTNFLFFILISWTPTYFTEVYPGQKGWVFNVLPWLVSIPASLSSGLLATKLLSLGCPVALCRKSIHTLACAGMATCLIALCFVKDYNTALALIIVAVASQAFSNTGVQVNIQDIAPKHAGAVYGITNCGGAIAGFTGTYLTGYILHLWYSWPAVFCMGVGVVLWGWLVFVRWGSAIPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDP9</accession>
    <name>A0A8B7YDP9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mucin-5AC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110979309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090692.1">
        <property type="nucleotide sequence ID" value="XM_022235000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDP9"/>
    <dbReference type="GeneID" id="110979309"/>
    <dbReference type="KEGG" id="aplc:110979309"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034956196" evidence="3">
        <location>
            <begin position="22"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090692.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="15909" checksum="E2986A9885A490F0" modified="2022-01-19" version="1">MGKGALLLIAVVLFLVPEIIAQTTTVASSTVTTDGKIDTAPTTLAPTDTITDSVGTTTNTASSGAPNDATTLVSDIATVDSAPTTDSPGGTTSPENVTTIILSTANATDVTVTATSQLGEPAILSPGAIAGIAIGAAAFVILGGVVIGVVVAKCKSEGSAVDAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGG7</accession>
    <name>A0A8B7YGG7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110979748</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091490.1">
        <property type="nucleotide sequence ID" value="XM_022235798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGG7"/>
    <dbReference type="GeneID" id="110979748"/>
    <dbReference type="KEGG" id="aplc:110979748"/>
    <dbReference type="OMA" id="QTDPRED"/>
    <dbReference type="OrthoDB" id="10070172at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091490.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40191" checksum="5DBD48D0C032FF03" modified="2022-01-19" version="1">MAHAVDSNWSLGASTGSLGSTASTPRLCTHRGLYRGSGGASAEIMSPQQPSPCMDSAGESPTTSWSPKERDRHNQNVVVAHIRLRPEIKADLPSAVPSSAREPSQGYSASHHHHRDPANHRSVNEELDKYMVIRQRSFHGYARSKQDLRQLPQTDPREEMDAVPSWLHRSKTDIYIERRRAKLATQRARRRGGSGGYNLDGITLGSLVDQLPVPGKRDHNGNAKLESRNSNLSPGESPGETRFPPLTLNRMKQMIQNDIQMYSLESQSVDRRRPSTTNALPTSSTTFPVPDPPPNSPPPPAQETTGHKRGRLRKQPLGSIPLRIWEPSLDYVLRSSAKELQPRQALSSLAHQAAVRQQPSPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGW1</accession>
    <name>A0A8B7YGW1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110979839</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110979839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091635.1">
        <property type="nucleotide sequence ID" value="XM_022235943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGW1"/>
    <dbReference type="GeneID" id="110979839"/>
    <dbReference type="KEGG" id="aplc:110979839"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022091635.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="13892" checksum="C20C92785D70766D" modified="2022-01-19" version="1">MADIEHCSIDSSLKRSNSALQKFSLEGSDSNRSFGVMMTSTQLVIILYVAATLWTRTEGVACNLCICLENSPTENCVHGFCYLYRSTPYCNCLGTGFMGNRCHLPVLAQTNSKNYRSLHDKDFAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHL5</accession>
    <name>A0A8B7YHL5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-lysosomal glucosylceramidase</fullName>
            <shortName evidence="1">NLGase</shortName>
            <ecNumber evidence="1">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110980408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the non-lysosomal glucosylceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022092743.1">
        <property type="nucleotide sequence ID" value="XM_022237051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHL5"/>
    <dbReference type="GeneID" id="110980408"/>
    <dbReference type="KEGG" id="aplc:110980408"/>
    <dbReference type="OMA" id="DQLCGFW"/>
    <dbReference type="OrthoDB" id="730489at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014551">
        <property type="entry name" value="B_Glucosidase_GBA2-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006775">
        <property type="entry name" value="GH116_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024462">
        <property type="entry name" value="GH116_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052566">
        <property type="entry name" value="Non-lysos_glucosylceramidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654">
        <property type="entry name" value="BILE ACID BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12654:SF0">
        <property type="entry name" value="NON-LYSOSOMAL GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04685">
        <property type="entry name" value="DUF608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12215">
        <property type="entry name" value="Glyco_hydr_116N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028944">
        <property type="entry name" value="Beta_gluc_GBA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl-hydrolase family 116 N-terminal" evidence="3">
        <location>
            <begin position="87"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl-hydrolase family 116 catalytic region" evidence="2">
        <location>
            <begin position="464"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022092743.1"/>
        </source>
    </evidence>
    <sequence length="847" mass="96848" checksum="A4F48ED41A29F184" modified="2022-01-19" version="1">MASETWESGNSMELSLEHFGVPEFGWRVPLDYEFPEKWGPLKGLRFFELIKLIPTFFRYLKFVWKMWMLGRRPFIDIVPIPFKTLYGVPIGGIGCGAINRGWKGEFCRWSLTPGIYTYNVVEVNQFIVRIQRPNQPVYQQVLYPGKVSNKHLTQSWQWHFPGDRAHYHGLYPRAWTVYRIPEQDVTLVCRQVSSVFPNDYKDTCLPVGVFVWEVDNHASTPVDVSIMFTWQNGIGAPSDKNGSRWNEGFCNKDTEGSCEGVLLHDDKSSMRCTMAVAAANQEGVKVSYCTDFDPNTSADEIWEDLLEDGHLNSSAVPTYETEEGELTAAAVCASDRVAKKSRGKMEFVLAWDMPRIHFKGNGHSYNRRYTRWFGHDGKAAIKLCSYALRSYSRWEKAIESWQKPILDEESYPAWYKSALFNELYFMTDGGSIWVESQEDQASSSAGDRTQDPSSRIAKLKKDMGMFAYLEGHEYRMFNTYDVHFYASFALTMLWPQLQLCFQDFIGTCVHATDDESYYQIASGQPAKRKLANCVPHDIGDPEEEPWKRINGYYQHDTCKWKDLNLKFVLITFRDFYQIQDLAFLREMYPKCKAVMETAKLQDIDDDGLIDNSGTADQTYDSWAMTGASAYCGGLWLAALRCMVEMAHILGHEDTDASEYSALLDKGRKSYEDKLWNGKYYNYDSNSKTCMADQTAGQWYLRACNLTKDRSGVDIFPTDHVLSALETIYQKNVLPFREGLLGATNGVKPNGKIDYSASLQCEEVWTGVTYGLAAHMIQEGLVKKGFQTASGIYHTCYNRAGLGFQTPEAILETQHFRSTGYMRPLAIWAMQWALENRHNRAASEDTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJH9</accession>
    <name>A0A8B7YJH9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Acid-sensing ion channel 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110980422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092777.1">
        <property type="nucleotide sequence ID" value="XM_022237085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJH9"/>
    <dbReference type="GeneID" id="110980422"/>
    <dbReference type="KEGG" id="aplc:110980422"/>
    <dbReference type="OMA" id="SKMVIYF"/>
    <dbReference type="OrthoDB" id="6502088at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022092777.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="58067" checksum="5A376BDC320CC2A3" modified="2022-01-19" version="1">MLKPSARIQALSSGGAVGPMPGSVEESDFVIADNASRSVDHEETTNRRDLRQTADDPVGLEVRNKRVLLFRDFMSETSLHGIKYVTNSKYHICRRFVWLILFLAAWTGFIILTADHFRTFSEFDTTTSLSYMPVSNLTLPAITICNYNAFKKSAVIESGWESLVPHLLPFLTTTSFPQNEVDVTSPDYENLTFPDWEAEELSTRWGHRIEDMLLECRWKQSFTCGPQDFEMTWTDFGPCFTFNGGDDRQPGGGESPYVANDSTSEEGLWLRLNLEQHEYIATPFDTAGFRILIHSRYDAATFVNPGIIQAAPGFTTIVPLTKRIINAKKYPYVTNCTDGGLKYYATYTPNTCLLECMADAVLEKCGCYMPWMSAPLGGDQEVCDLAIVAACGFDALVGVNCTCNMPCTEEQYMTRVSHTATPAQYAIPKLSAKYNMTAEELRNNIVDLYVYFEDMRVTVIEHKEAYDFAKLTSDIGGALGLLLGASVLTVFEFLDYLAVYHLFGLTLLKNSCQRIMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK20</accession>
    <name>A0A8B7YK20_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PITH domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110980869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093599.1">
        <property type="nucleotide sequence ID" value="XM_022237907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK20"/>
    <dbReference type="GeneID" id="110980869"/>
    <dbReference type="KEGG" id="aplc:110980869"/>
    <dbReference type="CTD" id="57095"/>
    <dbReference type="OMA" id="RLVFKPW"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045654">
        <property type="term" value="P:positive regulation of megakaryocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.470:FF:000002">
        <property type="entry name" value="PITH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="17"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093599.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23610" checksum="DF5ECAB62541D09D" modified="2022-01-19" version="1">MSGHGHSHGGCSGGHDHDPPDRGTEFSLYAKIDTDRVECLNEVTDGSGKLVFKAWDQRLDIDKYVESDDEEELLFNIPFTGNVKLKGIIVIGGNDDSHPAEMRLYKNQTNMTFDDTRSDPDQVFEMQHDTSGILEYNTKIARFSNVNHLSIHFSKNFGAEKTIVYYIGLRGEFTEAHRQEIMVVQYEAYANPKDHKTSLHDNVQQQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK66</accession>
    <name>A0A8B7YK66_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110980534 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980534</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093012.1">
        <property type="nucleotide sequence ID" value="XM_022237320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK66"/>
    <dbReference type="GeneID" id="110980534"/>
    <dbReference type="KEGG" id="aplc:110980534"/>
    <dbReference type="OMA" id="SKEICIG"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF130">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="87"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="770"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1006"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1180"/>
            <end position="1235"/>
        </location>
    </feature>
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        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1095"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1182"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1192"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1216"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022093012.1"/>
        </source>
    </evidence>
    <sequence length="1235" mass="138655" checksum="AC9EB7853953C565" modified="2022-01-19" version="1">MAVAGSALKRERFSESAFGIPLKTSTFSCIQPPVLHQVCYMTGGLTKLYQTIKANKDCIPDQESHYFTDEDGTFNPTEQVPLLAKRYQFIRILGKGCSATLIQAVDTFRPGNYQVAIKVLNQEYYALGYQESNNIEGLNRGDPQDFSGAVRLLNTFSFSGHFCLVFELLHPKPLHHYFKKIPTGSKKLQLVRKIALQLLQVLGFLRQENVIHADLKPENILCRTGDLSSGVKVIDFGNAIHCVYDELSLYYDDFELQTLLYRAPEVVYGLPFGPEIDMWSLGCILVELYLGEPLFFAVTKEELLQKMIAVLGPLPVQIFQRGKFYSEFEHFIGKPQTKLETQSKLFRRLGELHDYNFGSFILSILQYNPSERISVSDAFLHPFLAPEVAARFLLPPSSNACPSTYKKFNIPASVYTLSPVISSEVATDHLKSVDLLRRGTTSIQAEPIQIRRPKRAVAEVAPFAPKDTQTLHNDLDKVATVAFSNSSATKVASQSHGQYAVEPSLQECIGKQEQPEWCNPSVGLDMKATNQERFGCSSNNKLFGSKSNSIAFTNSRDLQTVLENSPTVEKRYKDGNVNNKTGIELGKINVTVQPSLTSDQKLKDPLVLSNVMSNSPSSKKEIGTLVSHIEKTIKAECQQLEGLTHMPEEARFKHLKEMKMEALKEDLEKSLEPKPESSMWYQLLYHDTENSKTELMDITEPSQNTNHHRTLTKTKAMVLSTSSNPQDVVSDSLNLLTPINYSQSPECSTQELKKDVDEATVHQISKILKRQSQDLSPRNTTLKSEKVSASLGSKKKSPKQDILLAKKSKQQTETTLLSEPMLNASIKNHEIPRHTEISKSCLDEPNLSKDVTINTTTTERKATMDFNPSKSLKLSQRPTFKLNPLSRIRRSKARAQERIKARHDFISQEPFHWWELNSGTQSKEDNHDAAEVIWQRDGNDKGHRAESKEVLPIKLVKDCQPSCQITTSLSCFNIPQKLESKTLSRNTKELKHSKGKLITKDTWKFKNPARSRGGVPQTSLQSQKLKKTLSDADLKSKRVKQNLGNPCSGKLHHHREIKIISQVQDPAEKPRMLQKKKSGVTRNIIPSPAKSGSNHHTDTSEHEVKPKHDVSKSGHSPDKGEISRSKESRRSGVRKKRKLEHPLSNYEDATLTRNVPIKSSPLENASVRITPTIQADSLVEVKNIRPKDDRSGTCQEEQSHQKLNLNPGNESEKDANGPASSSPSNSEEDDEVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMF7</accession>
    <name>A0A8B7YMF7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110981018 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110981018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093847.1">
        <property type="nucleotide sequence ID" value="XM_022238155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981018"/>
    <dbReference type="KEGG" id="aplc:110981018"/>
    <dbReference type="OMA" id="FIMATEH"/>
    <dbReference type="OrthoDB" id="3666223at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.40">
        <property type="entry name" value="BCL-6 corepressor, PCGF1 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047144">
        <property type="entry name" value="BCOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032365">
        <property type="entry name" value="PUFD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038227">
        <property type="entry name" value="PUFD_som_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24117">
        <property type="entry name" value="AGAP007537-PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24117:SF9">
        <property type="entry name" value="BCL-6 COREPRESSOR PCGF1 BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16553">
        <property type="entry name" value="PUFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1670"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1703"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="domain" description="BCL-6 corepressor PCGF1 binding" evidence="4">
        <location>
            <begin position="1813"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="799"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="953"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1038"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1234"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1439"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1554"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="968"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1041"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1234"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1474"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1554"/>
            <end position="1568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022093847.1"/>
        </source>
    </evidence>
    <sequence length="1924" mass="212097" checksum="80E57B03E5824371" modified="2022-01-19" version="1">MTSYVPKETQGSLLGPQATAGRANHSTRDVSPGPDTISTPTDLSSAGCGETNSMVVLSPSGDMSLPKKEPNEEGKLPGTDSKCHDEIPETLTKYKVEDSEGYPNPDMLHYPGRDEMGFGVGNNGEITRERLRQLATTRLAEQGRMGMPDANFIFQREAVAMQQKVNATVASKPLYSIGAPQRARIPKQPTRYGDQLHRNPLYDGPLNLVNRAAMQGNPYGGGHSSLDDATDLNKPLDLSMKSERLALPKVPKTIVDPRLMPLTNAEMIAKHTHTFSSNGNEVTSKVTSAQTMYRPPPMMSYGKPGRHGHAINPIQLVHRQHAAVPKDVPMSQGQLHPLASSGVVASHLQPNRSSLKRPAPVMARSASDIPMKRVVLDSMVAPSSTTPTPANIKSYQDASSRAALLAFERERGRSHAVALINQQDPDSNIRITDVRSIGQHTDTSHPAPVPKSTPSRSRTTKAAGAPVFHHIHYHHHHHHVPQPDEELLRQSSNGTPVVHARGAVPVHAGVIAQGGAAGPANGLPTHDIPSHRVAGRMVPGHEVPAHAMAAPNMASSRGDRHHGVLIKHTSTPVTTMTSPHLRRAHYQTRRRIVKSINPPTMASHASLAPHRMDPASTTSAPTRGHQHARAASPLKLVASSMAAGAQMNELLKPLDGPEQPAASAHVTNNNNNKVLLAEKLARPLRVDIPDDRAFVSHLGDLYTGQTNPVPLVRQVTNATSITKCLTSEANSSPKKSNSSGNESPTMPVLTPQSVYSPCFTTESMTNLTHNSSSVEPQPTSSPMFYSALTLSLYPRRQDATAEAVQKLPRAKDESPPNLHETSPEQLVPDHRMPNQLDTLIRRKIDQYALDAAAALDKNKREQKRHREIIQEPHDAYQLHMQELRRDRFEHRDKPKKRHTHGYSLKASMDKSKVHQLRGVSERILPSENHDDRNIFAEFMLKRQWYDGKMDARKPARETCPDQTDVIDLTTSPSSSPAPEVTNSVENKNGGSGATSKEKPEIGKNVRGLSRKREIISAFEEGRTVSVSEAIEAVFAANSPVPKREASGTETDHEESAVKQLQPNTGPPKRVTRGVFDQKDQPPKLVRVQDSPLVSATATAAMASTCVVHVITSPKPSTVLPPLTTTNGAIKIEPVFRCSSNSPSSAKLTVPFLTEAPPMDNPQLSSSSTDAAQSLVLSNTQVTSSLSALPQHLRFSPTEKTFSHDPRKKLLAAMNVQTPPASVCAVSPASVAASLSSTVSPSSGRSTPSKGSSRKRSLEITRLENTSSYVAEIPKRKQTVDLLTDPALLDREERALQRAMKRFNEMEKREKGTPTDAQTDPVVEPHTNSKKQNRLLIDKYSLSLRRGRGRGRKFAGFHRMQNHKDGAALTLNSHRQRRSFSREMRRLTSQGSRNSFQDFVPMVLEERTRHSQATRSSARERKIYHKNARYEMEIEKEERKYLERKRQKRSVSGSTSGEEESSCKTKGTPGRRRKGTEEVSRKSSDVSLAATELAQASDRESNFTSITSERTENPPEEEEGVARSPSMDTPLHVVIDPTNYTKMKFMTTSAYELHRKDSGKENKEVEAKPGGKRKFKTKHLGPATMIDSDVQKDDNVAVKAEVKESLPSASQPEPSPVKLVRPEPPAEMRRLMVNKKLGETILHRAARLAYDDVAIYCIDYDVVDINAKDNAGYTPLHECCVHGRLRVASHLLQHGADVNASASDGTRPIHDAVDNNWLALVRLLLRYGADPLIATYSGRTTIKLARTKPMKTFIIGYLSDINGEWELDEDDPYQSNLDLRWHITGTHSFYANDLAACDIFQDIPEGRKEESDGEFLFEVSDTPHLTSYNIRLPNDQRARNWLLLSDVTDQLNTTRADFLASNQTVRSVTMTRKEFTAAIEGSQLNHSPPQKSKMVLDETLGDYVVELLELTSDLRKILHIDEVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YND9</accession>
    <name>A0A8B7YND9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: lambda-crystallin homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094788.1">
        <property type="nucleotide sequence ID" value="XM_022239096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981494"/>
    <dbReference type="KEGG" id="aplc:110981494"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="2">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094788.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29694" checksum="E1BAA3F15F672CFC" modified="2022-01-19" version="1">MENICALIFSPYFGPSGMIGRSWTLIFISAGYNVTLFDIEHSQVSTCRARLLQSFTGQPKMVTFALKFSLHTTCSDKDGPHTINDLQQRNSVDLKSSQAWTGGYGCMIGQISWTTWTNWDHTFGQIFITDSSQPSLLLPIVPSRWTELSVVSLTQALMEEVGQEPVTAKREVDGLAMNRLQYATINEAWRLVADGVMXPEDVDKVCTNVLGMRYAFCGPFELIHPNAEGTASYLEHXGSTIQRVTSTFGPPPKFTGPAYDAVVSDRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNM4</accession>
    <name>A0A8B7YNM4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110981208</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110981208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094267.1">
        <property type="nucleotide sequence ID" value="XM_022238575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNM4"/>
    <dbReference type="GeneID" id="110981208"/>
    <dbReference type="KEGG" id="aplc:110981208"/>
    <dbReference type="OMA" id="IWGISTI"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48219:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48219">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022094267.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22604" checksum="5EE5F88B71C366F0" modified="2022-01-19" version="1">MSAKREMFQVITATKIVHVYGDDGTGANRDLTVVQADLASIPDGYYMIGQAAMPGKTSYRPGAPPSCIFLIKPAQELDPPLVKPPVDYEPIWNDHGSGGREDGSFWRAIPPQNYVALGDIVVNGYDKPSPAFTRKYACIREDLGLLLPAVLGEPSLWDDRGSGARRDGSLWEVKGDGLAGFFKVWSSYDKPGIRVYVLPGSVNASASGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNS8</accession>
    <name>A0A8B7YNS8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">G-protein coupled receptor 54-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17 18" type="primary">LOC110981226</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094314.1">
        <property type="nucleotide sequence ID" value="XM_022238622.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094322.1">
        <property type="nucleotide sequence ID" value="XM_022238630.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094329.1">
        <property type="nucleotide sequence ID" value="XM_022238637.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094341.1">
        <property type="nucleotide sequence ID" value="XM_022238649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNS8"/>
    <dbReference type="GeneID" id="110981226"/>
    <dbReference type="KEGG" id="aplc:110981226"/>
    <dbReference type="OMA" id="SMYVIPL"/>
    <dbReference type="OrthoDB" id="9445642at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF23">
        <property type="entry name" value="GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="87"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022094314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022094322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022094329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022094341.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44757" checksum="3BF6BD31FA018739" modified="2022-01-19" version="1">MTESAVFVTDIATTVVDLFAPTNFSDRMANTNFPLLVYSSPRYYFNGSLDNATTPAPPASFPAAFETTVRIMVPTIIAIIAIIGLIGNGTVLYIIFRYREMQNITNYFIANLAVTDVAMLAICAIPTAANIAGMPIGEGLCKGINYMQFVTVQATCCTLTAMSIDRYLLIVHAVRSRNTRTTTRAIIINVAVWIGSFVVHSPVAIFYVLENDKCFMKMGQNGRDARFYYLGSFLSMYVIPLVVILMCYAKILVIVWRKTSAGTESAQAHERSIRQKRKITRMVFIVVLLFAVCWAPIHCMILWEKFQEPFDLSMPTRMAVTVLRFFAFCLSYANSLTNPFIYAFTTASFKKHFKRVLSCSAPNECTDTKSMGPSTTYKKIGKFLVESPTSFKTRQPAQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPD8</accession>
    <name>A0A8B7YPD8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-related protein ced-10-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095138.1">
        <property type="nucleotide sequence ID" value="XM_022239446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPD8"/>
    <dbReference type="GeneID" id="110981674"/>
    <dbReference type="KEGG" id="aplc:110981674"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000118">
        <property type="entry name" value="Rho-related GTP-binding protein RhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022095138.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24945" checksum="2F6BA5DB9B46C098" modified="2022-01-19" version="1">MDVVRSTVSDFMDPDPTVEADNGDCAPHMATARNVKLVVVGDGAVGKTCMLWSYTHNAFPKEYVPTVFDNFSQLIKVDSVSVNLGLWDTAGQEDYDRLRPLSYPQTDIFLVCFSVEGPPSYSNVQTKWVPELQHHAPAVPFILVGTKIDLREDRETLTRLSQQGKAPFKKEAGEKLAAKTGAYKYMECSALTQKGLKQIFEEAVRVVLTPNAAPRPKKHRCKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPI8</accession>
    <name>A0A8B7YPI8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Adhesion G-protein coupled receptor D1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110981258</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094365.1">
        <property type="nucleotide sequence ID" value="XM_022238673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPI8"/>
    <dbReference type="GeneID" id="110981258"/>
    <dbReference type="KEGG" id="aplc:110981258"/>
    <dbReference type="OMA" id="RHTSHVV"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000058">
        <property type="entry name" value="Adhesion G protein-coupled receptor F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="10">
        <location>
            <begin position="51"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022094365.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36184" checksum="4E0CCDB662BF7541" modified="2022-01-19" version="1">MTSKIIGVWSNKGCETSEKEPLYTKCSCDHMTNYAVLMWLGEKAPEDREAINILTKVGCLVSIAALALAVGLLLYLRSTLSSERIIIHMHLMTVTLIALLLFLVGIDKTENKLVCQFITIGLHFFYMSMFSWMLVEGIHLYRQIVAVFDSEKSRIWVYFALGWGIPIIVVGITSGIFFNQYKDHEICWLEVKDNSIWAFLGPIIPILLVNVAVLFMVLRIVMSAAKLQQEKPIFNSVKKGARSSLLLLPILGTTWIVGYFQHNLLSLQYVFVTLNAFQGFFMALFHCFMSGEVNSALKQKIRRVKESSLGGASTVDSVRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPM1</accession>
    <name>A0A8B7YPM1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110980745</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093381.1">
        <property type="nucleotide sequence ID" value="XM_022237689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPM1"/>
    <dbReference type="GeneID" id="110980745"/>
    <dbReference type="KEGG" id="aplc:110980745"/>
    <dbReference type="OMA" id="CDANIGS"/>
    <dbReference type="OrthoDB" id="6134084at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093381.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35652" checksum="FE3974150A5142B0" modified="2022-01-19" version="1">MTRLDAGVEVLGLIIFGGMVIFVFGDQCNPLSKTKYAAENCVLQGFTYAHTTVRSRVTCERACSLDGRCKSFNFNDCNKTCELNLATRREHPRNFTAAQGRVYFDEDEETPRHSPCDNTCTYFDAVPGWRLVFRGVAGRGMKLSDMWTAACGDPGVMATAGSCRDDSLHEAWRSGALAVRWVKLSLCDFIGCRAELIFDGTGSDILNWFTKDRLISSPWKDLNSSSEINFFGIEGDVFFQHRRFFINHKYGSCPWDYGWLIVVDSLEMNGCDWERSQAYPIILCSTAEGYVRWEDAVTGGSSAAIARADYLTIHIDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPU9</accession>
    <name>A0A8B7YPU9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110981755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">Golgi stack membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022095304.1">
        <property type="nucleotide sequence ID" value="XM_022239612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPU9"/>
    <dbReference type="GeneID" id="110981755"/>
    <dbReference type="KEGG" id="aplc:110981755"/>
    <dbReference type="OMA" id="MESPLMM"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000010">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF145">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="6">
        <location>
            <begin position="262"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095304.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="54001" checksum="8F5553D94E66BA5C" modified="2022-01-19" version="1">MGGYRLKLRLIALLFFAVTTLITYVTLKHASFIFPQWEMNKNEFLGPPLHSPNHGSNIQKSHETFVFKQMILDNPSRKPEVGRQNHLENIPTFHQKAGRSKCNTSVTILAPSMRPFQAWREYKQLLNEFSEQSTQLSNTDQRSLHLECPRQLCNVDIQVTTDEVYLKTTNAVIVNMFPQIFKKNLLSFLSHLRQILNPQVHWFFYGVESPQMMTFWDPNIAEIQYHHSITYHSEADLQLPYGKYLSNHSDEMVSPERDWSANKTALIAWMASNCNNTFWPRHEFVSELKKHILVDMYGACGTLTCLPALSEKCTNLMTRYKFYLALENAECDDYITEKVWTNGLLQGAVPVVYGGRKESYERLLPPKSFIHISDFDSAEQLAAYLQFLHFHKSMYNMYHAWRNYGSFKVVYPPLNPQFFCEIVPFTLKPPPQLRAVKNSGYYKGCKSLLGTFVDRGSLKSFVPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQT8</accession>
    <name>A0A8B7YQT8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Protein phosphatase 1 regulatory subunit 37-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110981913</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP1R37 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095643.1">
        <property type="nucleotide sequence ID" value="XM_022239951.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095644.1">
        <property type="nucleotide sequence ID" value="XM_022239952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQT8"/>
    <dbReference type="GeneID" id="110981913"/>
    <dbReference type="KEGG" id="aplc:110981913"/>
    <dbReference type="CTD" id="284352"/>
    <dbReference type="OMA" id="HMEGCNI"/>
    <dbReference type="OrthoDB" id="10034042at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF9">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="643"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022095643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022095644.1"/>
        </source>
    </evidence>
    <sequence length="773" mass="84445" checksum="2E26B86EFEA91584" modified="2022-01-19" version="1">MASQASVVHGPTKPAATVEGSGSEDGMSPNVSPSKKHKLPGRHVNFPEGDTIVSVKVDPPNPWRHAKGTSTEELQAVYQAACYTMKVKPNAKVVQQLQNIKDFTKRMECFSLKGEKVDIRVVETLEEVFKRVQFNTVDMEAASLDDEAAVALFDMLEFYESAIRLVLASNRSIGARGWQAASRLLKRVSSLECLDIRNTNWTEYSMPMLARALRADITLSALHMEGCNISGRPLFLLLMSLKQNNSVRDLYLAENRLIPSDAIHLGSMLKHNRGLKLLDLRNNHIQDAGLSHLCDGLLDQMEGQLTTLVLWNNQLTQNGMTHLAKALPMLMSLETLNLGQNNLGNDGVHILKDALMKNRSLLRLGLYACRFGDQGTVALAEYVADNWQLIRLDLRENDVRTGGLMALSYAMKVNKVLLRLDLDKDVKREQMRGYEDLQKSLQSEISVHIQRNREISRSEQQKTEQGGSDQQEETGNMQQGNRTISSNHGNEQEQLESTEIGPQSPTTRVNPRTLNVRYVADPSSLPVETEASTANNDPLNLVSFDGGSTVGSTAQTSSTSDNSAGQQPMQASQGGGLRRDYKDELDSPTGVPLANNIQLLAHPMQAAMAAASPTILSQSTLVMGYGHFDSFIPVGNCASDTVPSIPQTDLMNENPTPSQHSPNATDATPSKATQPEEKKSDLKTQGDPMGDRGHTRDPLTLIVEGNCEGESVSLVNGTVEAGNKTNAETEGLEGANCQTGALSSSPDDFEKELDQIMAKVRSTATVQTDVKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRT4</accession>
    <name>A0A8B7YRT4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022095984.1">
        <property type="nucleotide sequence ID" value="XM_022240292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRT4"/>
    <dbReference type="GeneID" id="110982110"/>
    <dbReference type="KEGG" id="aplc:110982110"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07851">
        <property type="entry name" value="STKc_p38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000063">
        <property type="entry name" value="Mitogen-activated protein kinase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000769">
        <property type="entry name" value="Mitogen-activated protein kinase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="30"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022095984.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40941" checksum="6BF38987CF309ED2" modified="2022-01-19" version="1">MDAPVMGDLLPGGYHRFDLNKTTWEVPLRYQRLSAVGAGAYGSVCSALDTKTGTSVAIKKLSRPFQSAIHAKRTYRELRLLQHMDHENIISLLDVFCRGDSLETFRDVYMVTHLMGADLNGITKSQRLSDEHVQFLVYQILRGLKYIHSVGVIHRDLKPSNLAVNEDCELRILDFGLARQADDEMTGYVATRWYRAPEIMLNWMHYTNTVDMWSVGCIMAELLTGKTLFPGTDHIDQLNRIMAVTGTPDAEILAKIQSEDARNFVKSQPKKKKINFSEYFTGANKHAVDLLERMLQLDVDKRITAEEALRHPYVSKYHDESDEPTGERFDDSFEPQDLSVQEWRVLIFELIHAFQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUP4</accession>
    <name>A0A8B7YUP4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110982232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096205.1">
        <property type="nucleotide sequence ID" value="XM_022240513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUP4"/>
    <dbReference type="GeneID" id="110982232"/>
    <dbReference type="KEGG" id="aplc:110982232"/>
    <dbReference type="OMA" id="IWERISV"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044823">
        <property type="entry name" value="ASIL1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31307">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR ASIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31307:SF4">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR ASIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="3">
        <location>
            <begin position="109"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022096205.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53353" checksum="E2F071C76ADBBDE5" modified="2022-01-19" version="1">MAARRTKESLLSDTQFVFPVSVHASGEGNSEPIVPEDGVNTRRKEGYSLREDRKRSFAEFDCTDSDQPEYPYSDEDGATPAPRPARSVPSLLDFCGPADDRSSSKVRVRNWTHPETKSLLAIWSDPEVQAELKSSIHNSWIWERISVLIGQRHPEFQPPRTAAQCKERLTYLRKQYRKSARLRARGKWPNVGNIKIYLDELHSVLGKRSPGKSKSTAPSTASSFRARATNSASQPPTTPSAVKAALAARPQAAETPELLLPEVPESDYDENEDDDEEDGTEDLEETDGNDMQDFFGRNQSQEAEDDLPAEMPSNHDKITEPGHSSYNPTAATNLAKTSKRPASSRRNPGQPRGRPKAPSGPPRDDLTVAQAITDSVQRFIDHQSHHLTEQHKLLQRYLKFERARMRWEMDMETRRMKWEEEREMREEERRQRQEELEAKRVSDNREFMLQMAVVLGNGESGAGKDSNSSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUV8</accession>
    <name>A0A8B7YUV8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982275</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096270.1">
        <property type="nucleotide sequence ID" value="XM_022240578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUV8"/>
    <dbReference type="GeneID" id="110982275"/>
    <dbReference type="KEGG" id="aplc:110982275"/>
    <dbReference type="OMA" id="FWLFFID"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF26">
        <property type="entry name" value="RETINOL DEHYDROGENASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022096270.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37272" checksum="A298439E4433A6BA" modified="2022-01-19" version="1">MVELSVLWTRILPLLAALYSVYYWQFITSRQHYKGDAILNGKTVIITGGNSGIGRVTALDLAQRGARVILACRSLQKAQDAAEEIKARTGNSEVEVRHLDLASLQSVREFASGILESEERLDILINNAGIGFAREGAVTKDNFHLIFGINHFGHFLLTNLLLDLLRKSAPSRVITISSIGHEWVFSPLDLTRGDHSSSGSHGSPVLYPHLRSYFQSKLANVLFARELARRLESTGITSVSLHPGVIYTPIWSDMPVDWITTINHFFCRPFFWLFFIDEEAGAQTTLHCALDDSIPYLSGSYFDNCQETAPSALAQDDELAQRLWEVSCEATGLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVB8</accession>
    <name>A0A8B7YVB8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily domain-containing protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110982497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096632.1">
        <property type="nucleotide sequence ID" value="XM_022240940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVB8"/>
    <dbReference type="GeneID" id="110982497"/>
    <dbReference type="KEGG" id="aplc:110982497"/>
    <dbReference type="OMA" id="EWYVNIS"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17389">
        <property type="entry name" value="MFS_MFSD10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000223">
        <property type="entry name" value="Major facilitator superfamily domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022096632.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="52057" checksum="0A30E70E57A7B8A8" modified="2022-01-19" version="1">MQEKNAHLHNANGNYQSNDTSCKFTPRQLDVQKRRDDSDNHRMISIVFLSLLIDLLAFTMILPLLPSLLDYYAQHDQGGLLPELQSKIDSFRELLGIPDTQKYNSVLFGGVIGSLFSFLQFVASPVIGAASDVYGRRPLMLVTMTGIAISYCVWAVSHNFTLFVIARVIGGISKGNVSLSTTIVTDVSTASTRGKGMALIGIAFSLGFIMGPMIGAYFAMSAGGKGEALYVKPALFAIILAVADIVFIFLLFKETLPMHKRAKSFGSSFKDACDLISPLSLFLFSAVKKLKVSELRMLRLLGLCYFMYLFIFSGLEFTLTFLVHQRFQYTSMQQGKMFVFIGAVMALVQGGYVRRISPGKEKRIAIIGILVLIPSFIIIGCIQTSVPFYAGLALFSFAAGTVVSCMTTVVSAYGSVDQKGTIMGIFRSLGALARASGPVVASMWFWSLGPTVCYSVGGVLLILPIVGLSRVVPLKVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVZ9</accession>
    <name>A0A8B7YVZ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Fibrillin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110982966</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097489.1">
        <property type="nucleotide sequence ID" value="XM_022241797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVZ9"/>
    <dbReference type="GeneID" id="110982966"/>
    <dbReference type="KEGG" id="aplc:110982966"/>
    <dbReference type="OMA" id="QCNSSYT"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000010">
        <property type="entry name" value="Pro-epidermal growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000008">
        <property type="entry name" value="Signal peptide, CUB domain, EGF-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF4">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00907">
        <property type="entry name" value="THRMBOMODULN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="315"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="438"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="477"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="560"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="681"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="802"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="849"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="920"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="993"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1026"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="1066"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="997"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1014"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1070"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022097489.1"/>
        </source>
    </evidence>
    <sequence length="1147" mass="123166" checksum="4CBB818D3F2EC3EB" modified="2022-01-19" version="1">MVGVSADRPRRTWRGLTWDLKALGPSSGLAGMVLCAFVLAGAVSGEGTDVGADGGRMKRMVQTNVRGLHVCRSQGGYICCPGWKPNPGSGLCLTPVCRGSCGEGVCSAPNTCTRCQQTPYGTTTCQRTAPAYSRSSYPVHPYSQTQYAALNRQTSQLVSAPHYVQGYQTSNSPRYQTHAMQGYQTRPSYSTSGGRSCSTLGCRYGCGSTATGSTSCTCPPGYMLASDRRSCRDVDECSRYSGLCQQNCRNTLGGYQCSCTTGHLMNNRRTCSDSRGCTTCRGGMPAPGPVTLPGSGSCPAGFQPQRTSQGIRCVDIDECRSSQCDQECINTEGGMRCECGPGFTLSPDGQGCTDIDECARSDWQPCHHTCINSRGSFRCSCQPGYYLHQNGRSCLDVNECTQGGGQVCHHICQNTHGSYRCSCRPGFELQSDGTTCRDIDECSQGSNGCSGSCINTIGSYQCSCTQGYTNRGGTCVDIDECQMSNGGCEQLCVNTQGSFLCSCRQGYTLNSDARTCTDVDECGQFSGRVCEHGCENVDGTYQCRCPSGFRLHANKQNCIDINECVEQQGVCHYRCVNTRGSYHCICPPSFQLAADGRMCDDVDECTVSNHGCQGGCENTMGSYHCTCAEGQLGTGDLYCGKQPSGCTSDMCSHKCVDTGVGHQCMCPRGYQLHSGGRHCEDKNECLEVGKGGCQHQCTNTMGSYYCSCYPGYRLHYDRKHCVPSPGCNTCNVCPAGFRMNTQTRRCEDVDECSSPPNHCGTTRCSPNRAVCSHNCINTVGSYSCTCRPGYLIQPDGYTCAQDGPVCSPPCRNGGTCRYSRQCGGNTYNCRFTECTCRAGFTGPHCENVLPTSCQPPCMNGGQCVDGICQCTAGFTGPSCSSDKNECLNHRCEHHCQNTFGSFQCLCRGGYTINADGETCSEIGCFPPCMNGATCVNKACVCPEGFSGPNCQTDINECATDNGGCEYICRNTYGSYVCFCPRGATLSPDKHSCSGVTCSPPCNNNGTCVNRMCRCPPGFTGPTCLQDINECNTDNPCAYQCLNTYGSYECVCPDGTQLGDDRRSCEDLFDCIPPCQNGGTCRSGTCICPEGFTGPTCTTDIDECQDPTRCTFQCNNYYGGYQCLCPLGFMLGEDGRKCVVKNECPQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW91</accession>
    <name>A0A8B7YW91_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dynein axonemal heavy chain 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Axonemal beta dynein heavy chain 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ciliary dynein heavy chain 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC110981882</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095571.1">
        <property type="nucleotide sequence ID" value="XM_022239879.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981882"/>
    <dbReference type="KEGG" id="aplc:110981882"/>
    <dbReference type="CTD" id="55567"/>
    <dbReference type="OMA" id="ECMREKK"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        </source>
    </evidence>
    <sequence length="4054" mass="462434" checksum="6A5255B69E8CD23E" modified="2022-01-19" version="1">MDRARVTGTPLLSCSQTRGLPGLPPLPKDAAKHPSELYQIVLKHSEHPPIMQGMSWTLAAPFKEQKYSRTPSESIANNYTPSANKLNIKALPRSNLARSVTQPSMTRKRSHSPQRSPRSPQPGDIPPISPRAKTFVGRRAKAQLNGHAVLPSSRPMTPIEQLDTMLKLEQEEDANHGEPCERDLERYHYYITKGLTPEMLALPPDNMMDNVRCYIPRALLEEVGLQKLRSSLEEEIYSDYEFSSRKAIVDYILKDPDEKSRLHIAWIPRPFPRRIIRAPVPWHNSYLTNKDCNTSHLFITNNIMLELQNLWYDRFCTLRFVRLEDLLSAELPLLPEEFENLVKKQCAEARQVLQMSWIPTCAEIFMDRKELWGHLVPQNDIDSTQRVQEFFACVAALMSIQLRSMVINSLADFLEFFQIHENGNEFGDEYQELQYVMAQIMIVKLKVEEPRITFDPPFRECRDIILRCFSEIISSADQLQRVECAIFPQMQNQRLLLRSVKVDEPLVEDFIDKAMQIFKLNTVGPTRYLNTYKKYNDLLNTKADADVAAFLKEKHSLQGFVKKIASYQQLKDEIALLRITVPLSMFCLDCRLLNADLCSRAQKLKEKLILFEVDENRMLNKGICRRYDEIADRLGEMPSTTAEIVELSDFLRESSEVTVFKLKDEIDEAANRLMFLLDYANLPYEDIKLNSTVFHWPEHIQTVFEVCRNRLMTRREQAEEEVRKKVQRFEEKLNEYNKEVESFRKKEILSMDEMTTNVNRLNELQQLLEASQDELDGLNKEEQLLEWEPSQFPILSTMFTTKQPYDQLWNTALNFHTKYETWLNGPFQDLNAEQVNDEVDGMFRTMYKLSRSFNDQPGPQRIANNVKSKIDKFKVHLPLLGVICNPGIRDRHWEQMSEIVGFELKPKPESSMYHMLELGLTKHLEKLEEIGAAASKEYSLEKALEKMKTEWADVHFEFVPYRDTGVSILSSVDEIQLLLDDHIVKVQTMRGSPYIKPFENEMKEWEEKLVTMQDILDGWLKCQATWLYLEPIFSSEDIMAQMPEEGRKFGIVDSYWKDIMTEAIKDTKALVCTAQPNMLGRLNESNQLLEEIQKGLNNYLEKKRLYFPRFFFLSNDELLEILSETKDPLRVQPHLKKCFEGIAKLEFTDQQEIVGMISAEKETVPFATKIFPAKAKGMVEKWLLQVEEVMISSVRKVIQEGVAAYANLPRNKWVLDWAGQVVLCVTQIYWTQEVAKAIKEPGGLKKYLEQSNKQLAEIVELVRGKLEGGARVTLGALTVIDVHARDVVEQLGNLGVESTNDFNWIAQLRYYFDGTNVNVHMITTDIAYGYEYLGNSGRLVITPLTDRCYRTLMGALKLNLGGAPEGPAGTGKTETSKDLAKAVAKQCVVFNCSDGLDYKAMGKFFKGLAQAGAWACFDEFNRIELEVLSVVAQQILSIQRAIQQHLKRFQFEGTELTLNPTCTMFITMNPGYAGRSDLPDNLKVLFRTVAMMVPDYALIAEISLYSMGFVDARSLAGKIVATYKLCSELLSSQHHYDYGMRAVKSVLTAAGNLKLKYPEELEAVLVLRAIKDVNLPKFLAQDVPLFEGIISDLFPGVVLPTPDYAVLLETLNENIKKLGLQPVPWFIEKIIQVYEMMLVRHGFMIVGDPMGGKTSSYKVLANTLGDLHTAGLMGEFRVIHEVINPKAITMGQLYGSFDPVSHEWTDGVLANTFREQAASQTEDRKWIVFDGPVDAVWIENMNTVLDDNKKLCLMSGEIIQMSNKQNLIFEPADLEQASPATVSRCGMIYMEPHQLGWKPLRDSYMDTLPTSLSQEHRELVNDLFEWLVDPCLDFIRHECKLFINTSNIHLAQSLMKLYTCLMDEIKDSGTEGHDTMSNQQITLWLQGLFLFCVVWSLAGTMNGDSRKKFDQFFRLLISGTHPDHPKPKSIKITKSNSFPERGSIFDFYFQKQASGSWCEWIDYLDKSKLKIPAGAKVSDLIIQTNDTARQIYFLDTYMTHARPMLFIGPTGTGKSAITNDYLVGLPKEHYIPNNINFSARTSANQTQDIIMSKLDRRRKGVYGPPMGKKCVIFVDDLNMPAKEKYGAQPPIELLRQWVDHGHWFDRKDTSKLEMADVLLVAAMGPPGGGRNDITGRFTRHMNIVAIDSFDDATMTKIFTAIADWHFAQGFDSAFVRLGKIMVMATMGVYKATVSNFLPTPSKSHYVFNLRDFARVIRGVLLIPSTHLKEDDKDKLIRLWIHEVYRVFYDRLVDDKDRLTFFDIVKEMTQSHFKTSVDKVLSHLTPSGKLIDDNVRSLFFGDYTNPDSDQKVYDEVTDLKELTSTMQFYLGEYNQISKAPMSLVMFKFAIEHISRVSRVLKQDNGHALLIGIGGSGRQSATKLSTFMADYELFQIEITKNYTNNEWREDIKKLLLKSGAEGKQTVFLFSDNQIKDESFVEDINMILNTGDVPNLFPADEKAELIEKMQQVARMEGRKIEATPLAMYNYFIEKVRKNLHVVLAMSPIGDTFRNRLRMFPSLINCCTIDWFQPWPEDALEMVANTFLEDIEDIDDNVRKECVFMCKHFHESVRKLSESFLEQLRRHNYVTPTSYLELILTFKKLLGLKRAEIMTLKNRYLGGLEKLAFASSQVAVMQEELTALQPELIKTSEETEKLMEKIEQDTVEVEAQKEVVAADEAVANKAADEAQAIKSDCESDLAEAIPALEAALAALNTLKPSDISMVKAMKNPPSGVKLVMEAICIMRNIKAERKPDPSGSGKMVEDYWGPSQKLLGDMKFLDHLKTYDKDNIAPAVIKKIRDKYIPNPDFEPSVIRNISTACEGLCKWVRAMDVYDRVAKVVAPKKAKLAEAEAELAVQMDMLNTKRAQLKAVTDKLQALNEQLDAMVQKKKELEANIELCSQKLVRAEKLIGGLGGERDRWNEAASMLGEKYIKIIGDVLISSGVVAYLGAFTVDFRLKATEEWQKLCQERLIPCSDTFSLSATLGEPVKIRAWNIAGLPVDSFSVDNGIITSNSRRWPLMIDPQGQANKWVKNMEKANQLSIIKLSDSNYVRTLENAIQFGKPVLLENVGEELDPLLEPVLLKQTFKQQGVEYLRLGENLIEYSHDFRFYITTTLRNPHYLPEISVKVVLLNFMITPLGLQDQLLGIVAAKEKPELEEKKNQLILESAANKKQLKEIEDKILEVLSSSEGNILEDETAIKVLSSSKMLSEEISAKQEIASATEKEIDETRNGYKPVAIHSATLFFCISDLANIEPMYQYSLTWFINLYLQSIQNSKKSSVLEERIENLNDHFTDSIYRNVCRSLFEKDKLLFSFILCIGIMKSRGTIDDEEWRFLLTGGVALDNPFPNPCSEWLSDKAWAEIVRSSNLATLNGFKEHFEENHATWKQVYDSATPHELKYPVPFDTTGGLARMIILRCLRPDKLVPAVQDYIVDNMGRSYIEPPTFDLAGSFADSHCCAPLIFVLSPGADPMAGLLKFAEDRGFGGSRIQTISLGQGQGPIATKMIEDALRQGTWVVLQNCHLASSWMPKLEKICEEVIVPEATHKEFRLWLTSYASDDFPVSILQNGVKMTNEPPKGLRANLLRSYLNDPISDPEFFDSCNKPQIWRRLLFGLCFFHALMQERRKFGPLGWNIPYEFNESDLRISMKQLLMFLNDYDDVPFDALTYLTGECNYGGRVTDDKDRRLLTSLLSKFYNDRILEEDKFPFSDSGDYFCPADGPYQVYIDYIRSLPIIPHPEVFGLHENADITKDNQETQQLFDGILLTLPRQSGGSGKSPQEIIEDLAVDILSKLPSDYNLEYVMEKYPVVYTESMNTVLRQELIRFNRLTSVVRSSLQNIQKAIKGLVVMSSELEDVFDSMLVGKVPAMWAAKSYPSLKPLGGYIIDLLARLKFLQDWIDHGVPKCFWLSGFYFTQSFLTGVSQNYARKYTIPIDHLGFEFEVTGHEETVEEKAEDGAYVYGLFLEGARWDRSLMRLNESNPKILYDTIPVTWLKPGVRANFKAVPTYTCPVYKTSARRGTLSTTGHSTNFVMMLELPSDKPQAHWINRGVASLCQLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXF0</accession>
    <name>A0A8B7YXF0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110983230</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098004.1">
        <property type="nucleotide sequence ID" value="XM_022242312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXF0"/>
    <dbReference type="GeneID" id="110983230"/>
    <dbReference type="KEGG" id="aplc:110983230"/>
    <dbReference type="OrthoDB" id="1366754at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031569">
        <property type="entry name" value="ApeC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324:SF33">
        <property type="entry name" value="MUCIN-5AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19324">
        <property type="entry name" value="PERFORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16977">
        <property type="entry name" value="ApeC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apextrin C-terminal" evidence="1">
        <location>
            <begin position="311"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Apextrin C-terminal" evidence="1">
        <location>
            <begin position="579"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022098004.1"/>
        </source>
    </evidence>
    <sequence length="786" mass="90000" checksum="817E9CBF84E369B3" modified="2022-01-19" version="1">MGIGKYLPVFYQLSARKHMGLIGNQRNVGYVSGVRANSVCMLDVERKVVKEIFRVQVDPQVSFDGTHLIPDQVIFSPRESCIPSVATSVFEGTESYQNKLKQYVKLLGNTEGAWLGYEFCKSAKYGVTSQSIDVGHHVFFDEVTVCNLGQARYVTELAFPDRFSLSRGFVASACALPKSFDLEEYMQFVDTWGTGKYYSSDGKSISLDMANFRAHLLTEPALFGDHVETLTLGDTTSPVPVSFDMIGIEEVFSVERWQLLEQYVLERLCSADEDADFSAKRANLIEALKAYPYWHNARKSFNPVVQSAITWPVGTYSLPMTNSLSGCPNSAFFWKTGRRFQDTQDLFASNDWSDPCHILGPYARNNVQQNFCSKTDAVLSEDDMTEWDAGEYCIFKKGTCPVGFSEGWVKWDDQDALNGNTMSGVLPDGIYDHNTLIYFCCREDGDPLSPILLPTEDPFFLFRKNDVCQAVEGMTLIEEWFKWDGEDDFIDFTKYYGGSHPYIDSWDDDHKLYYYKTRGIVAVQLKAQTRIRGLHLTVPWFARTGLSNKHDTMDNIMRPLFLVAYFSSAVWAAKLPSIWPRGTYALPMPIGGCPNTYYNWDTGRRYQDTQDTFPNNQWSKSLHLYGSKSLTHVEQHFCVKKDYDMGSRSNPDWEPGQYCIFKKGKLCPDRFSEGWIKWDDQNIFNRNDHSGELPEGVYDDDTKIYFCCREDGDAGTPLTLPVDKPFFLFRKNGDCQAVDRMTMLVEWFRWDGEDDLIDLDKYRDGSVPDLENKSGDNHKLMYCYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0H0</accession>
    <name>A0A8B7Z0H0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110983824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099099.1">
        <property type="nucleotide sequence ID" value="XM_022243407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0H0"/>
    <dbReference type="GeneID" id="110983824"/>
    <dbReference type="KEGG" id="aplc:110983824"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034714982" evidence="7">
        <location>
            <begin position="23"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="8">
        <location>
            <begin position="46"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="201"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="307"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="332"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="345"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022099099.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="48622" checksum="55FD174296EC8D53" modified="2022-01-19" version="1">MASLVSLKVFIIALLEVISSSAQPLEARTVQRPLLSELPCSSDFGFSGELLGLMSGAIPDSDITASSSWNASYSASSVRIFSGSSWSPRVNENQWIQVDLGVFAAITGVIIYSDFGEVNYIKTFTVQHSTSGAANEWQNLTDEVGQTIQFEVSSEFWNGMTVISFPDALFTRFIRLSPTAWVGHIRLNMEFTGCRDIDGMLRLVGGDGHSGRVEVLKGGIWGVICDNGWDDQDADVVCQQFGLNEMGEATSLPLGEGEEAPFLMSRVTCRGTETRLVDCPLVCGSESLQCNSSRAAGVSCKPPRDVIRLVGGSSPTNGRVEIYQNNTWGTLCDTYWDVTDADIVCRQLGFSGAEEAKSGAHFGQGVGPVHMDGLACDGSESRITDCPSLCWEGTRCNHTQDAGVVCREGATLQKKESATGSGLPPHEFSVVTIDDYFFFSPSSDWIPPEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0S5</accession>
    <name>A0A8B7Z0S5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Probable G-protein coupled receptor 173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC110983542</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098553.1">
        <property type="nucleotide sequence ID" value="XM_022242861.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098562.1">
        <property type="nucleotide sequence ID" value="XM_022242870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0S5"/>
    <dbReference type="GeneID" id="110983542"/>
    <dbReference type="KEGG" id="aplc:110983542"/>
    <dbReference type="OMA" id="CIFEHRH"/>
    <dbReference type="OrthoDB" id="6129346at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051509">
        <property type="entry name" value="GPCR_Orphan/Phoenixin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19268">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19268:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="97"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022098553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022098562.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48016" checksum="FC78D641D284FCB4" modified="2022-01-19" version="1">MFHISAKVRPPARLPPEIYAALPTTESAPGMSTPLDLGLGGSDNSTVDDSTVVIPSKTVTNIVDTGDGNEVDLPDDHGPRVLWCSSLILVIILSVVGNGILSVVVFGNARLRRPCYFFLFNCALADFVRSVLCFPFVVSAVISRDWIYSDSLCEILAFFNVYLTYGALYTLFLISIERYVVLRFHRFHRQKLKGPACLLLVLASWALAVSMAFPPVFNTRTYSFIEVENQCTFKHREYKTNETMCFLMFFVAVIAFTHFAYFRVFLFMRAHRKMRPMQFVPAVSNNWTFYGPGSTGQAAANWFLGYRQGPTPPPLIGLAPPSNNNSTSLSKSDFEREEKFCKLSLSISISFSVLWLPYTIHCFWQVFQPANPLPHSYVSLATWMTFFQACINPILCFVVSKEFRQIALQHVFGASAFQQDGHNVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1W6</accession>
    <name>A0A8B7Z1W6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110984088</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099599.1">
        <property type="nucleotide sequence ID" value="XM_022243907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1W6"/>
    <dbReference type="GeneID" id="110984088"/>
    <dbReference type="KEGG" id="aplc:110984088"/>
    <dbReference type="OMA" id="WFLLPYM"/>
    <dbReference type="OrthoDB" id="10067585at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099599.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="23579" checksum="1B62D28AEF3AECE5" modified="2022-01-19" version="1">MAILKRCLCVDNVRGGSALSAVYSVISSLVLLVLAAIQLSAITELPAKYNTGNITTVSALYVVSVSLVVVSSLLVLWGTSRDDRWFLLPYMIVMPILILWQLVGLISFLYLIISLSLDSTGLFAIVIVVVQGLNFLFNYPIFYSSIAATIMGLHLVLNIASFLAVTSQYQELRDGRGTTYDVYASRRGTDRNHEPFGGMLNQPAHGTPLRSITTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z207</accession>
    <name>A0A8B7Z207_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Interferon-related developmental regulator 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110983677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098810.1">
        <property type="nucleotide sequence ID" value="XM_022243118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z207"/>
    <dbReference type="GeneID" id="110983677"/>
    <dbReference type="KEGG" id="aplc:110983677"/>
    <dbReference type="OMA" id="HISGRHI"/>
    <dbReference type="OrthoDB" id="18978at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006921">
        <property type="entry name" value="Interferon-rel_develop_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04836">
        <property type="entry name" value="IFRD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon-related developmental regulator C-terminal" evidence="3">
        <location>
            <begin position="373"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022098810.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="47561" checksum="A64DFF37AF8EA754" modified="2022-01-19" version="1">MPRRKVRKKGSARGGDSSEGDTEETGSVVSSHLSEPDSILEEGPELADNVRVDETDAQERFEEKIKEYIDGTTQKSVNGRKDCLEGLKKSLSRKVLTDFIEQRKVTISDCVERCIKKGKSEEQALAASVGTLLLIQLGAGDDSEAIFNDLLPLLKTTLADKTVAPKGRASCALFLGLGCFLAADNYETVLDCMVALEHVFSLSYLKGDGTVPSHTPAVTALHCAALSAWTLLLSIAPPARVPQLVDSHLGKLPTLLHSDDVNLRIEAGESIAMFYELAREQNEDFDMDNVDELLVTLRGLATDSNKYRAKKDRRQQRSSFRDIMRTIEDNDIPHEIIKFGPEILELDGWVKKQQYVAFREVLGSGTNIHLQENLLLRDIFGLGAPIITSGPGAPKRANRSERHHYNSQAFKARTKVRSKQRDKRSYNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3T5</accession>
    <name>A0A8B7Z3T5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transmembrane protein 131-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110984409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM131 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100299.1">
        <property type="nucleotide sequence ID" value="XM_022244607.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110984409"/>
    <dbReference type="KEGG" id="aplc:110984409"/>
    <dbReference type="CTD" id="23505"/>
    <dbReference type="OrthoDB" id="168404at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055435">
        <property type="entry name" value="Ig_TMEM131L_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055436">
        <property type="entry name" value="Ig_TMEM131L_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039877">
        <property type="entry name" value="TMEM131-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056311">
        <property type="entry name" value="TMEM131_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055437">
        <property type="entry name" value="TMEM131L_Ig_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022113">
        <property type="entry name" value="TMEM131L_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050">
        <property type="entry name" value="RW1 PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22050:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 131 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24495">
        <property type="entry name" value="Ig_TMEM131_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24498">
        <property type="entry name" value="Ig_TMEM131L_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24499">
        <property type="entry name" value="Ig_TMEM131L_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24501">
        <property type="entry name" value="Ig_TMEM131L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12371">
        <property type="entry name" value="TMEM131_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1123"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 131-like N-terminal" evidence="9">
        <location>
            <begin position="101"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131 second Ig-like" evidence="10">
        <location>
            <begin position="201"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131L third Ig-like" evidence="11">
        <location>
            <begin position="434"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131L fourth Ig-like" evidence="12">
        <location>
            <begin position="830"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM131L fifth Ig-like" evidence="13">
        <location>
            <begin position="1027"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1189"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1783"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1837"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1189"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1221"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1240"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1323"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1381"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1410"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1440"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1459"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1601"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1708"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1725"/>
            <end position="1750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1759"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1803"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1850"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1885"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1921"/>
            <end position="1933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022100299.1"/>
        </source>
    </evidence>
    <sequence length="1962" mass="214474" checksum="D979B6653ADCD52F" modified="2022-01-19" version="1">MMSAVITNMAVFGRTELHSNGMAHMWLTLALSILQLLPTHLDTVKAHGQAFVQTDFSELPHFVEEVTLNKGDLTNQGLNTHDKNSVKTLGLGLYKQWDLDLSLQPPMLDFGEHAIGMPELATVQVFNSHPENMLRMLSISGSTPHFHCSFFQDKVVPPGGNTTFEIVFLPRVAGNAENTIFIHTSAGTCPYQVFGVGVPNPYRLRPFVGAKVPINTSYSPLITMHNPYSSGLMVTEMYSSGGELHLELPTGSQDAPQNLWEIPPYTTRSVMRASFTGRVESNHTAFIRIKTNHSKRLDDEENELLMLPVEVEVSSAPGIYSSLEMLDFGTLRSLDSPKTLPLYLINTSPKSVQILSITSMRVNNALTIDFKPLVLKPSDTHTKVAEVTFHPLKANTSRLWSGKLIVKTKDKNIKLQIPYQAHVLQGTLSSDQQSKLFYLTPTLVESAETVVRPVALTNYFNFTLVIHQVSFPEDVKNIFKVTGFNEALIIQPQTTDSSLSIVFSPNTSTTSLQTFLRLGSNASVFSMGIHVYTGKLKYSVHSVDDKNIDLGVMSVGDHRSMLITLVNTNPIDVPIQSFSCNLDDCEAQVLGVEPGEGKLLTKQHDAFSIRRKSLVINEHHFAVLRLEVKAPLTEGQFLGSVVIETPHERVSISAKLRTVEGCLGVKPEHVIFRPAFPGTTQSVSLMLVNSFSHRMKLESILPDPPDKRFYYRLPKKTPVVEIEPHRKQKVGRIVFDPKAACGEDDSCYVGLSTQSLDGEVWLSSLALPDETQDVDKLFYNHLHNRWQSLEQTGKTIFNATLKVNSNLVKDKELPVTAVLEWPRLIRKDKIEFPLTYIENSSISEVQILNPSDTLILVQLLPVALYQDPTSVLDFLTDRFDPELIETDDPSVFFLANNTDKDSSEKCLKNSSCGVIEETFGVRPNRTALTVPIKPHQNVTVAIGFKPSDGRERISLILIRNNLTILDAFMVRGRGARGELRFNSKMPSPNSNLLFELKPTHLEDCDRSSPKARVPPNFTVKRSFTLKNTGQLPIYIKTFSINGYDCNGYGFKVLQCRPMELVPNETKRLDIAFTPDFTMSRITRQLKVLTYNQEELEYTLIATLPPHMLSTCAAALPRPQWEHLLYIISVILMGVLFLGILTASYLEALRLTEPMPATQPGPPEEKGEMGRLKCFDLRSIAAGIKIGGGGGGASGGGGAKPSSTSSVLSTLGEKLSFRPKRSSSPSTSTRGSTSSVANNTRHSEPKSQSERRLSPDKDKVKVNSWANGSVPAKQSNALNTSNSSTPSPSEAAPNRRSTGKARRRPVDSEWNSNYANNTSSSRENSNRHPEHPSPRSFVEDISPAMVQDPPAHEAQDSLEVNTSVNKLARNSKRKSNRPTTTSKREEHDKKMTGSKRKEEMMREAVDRDDSSSISTECSNPESEPSDKSGKQTFHQADSEPSWPSNKSKSKALSSGGMGLDDFKFEDVKSRTKPRKNAKMDPAFYGDVCRPSTLELPYVPHGEAGRRVKQNSKEPTSPHSIAAKIAAKATKKALKTAKPEQATKSIDGASETASTPSSEVDKDSPPPLWEQVKPMPSSQGRQLPVQAKHPEQPTPAALTTTNTSNSHRGKGSSSKNSSTKSSQFPETAAAATAAAAAAGNASGRPSSYSKAVAGAVPGTNSETSPAPEESTKKTKLAKTKSMPEKTSAFTAVGDIAGRPGAIGSKGISPKTRTWPWTGQSGQPEMLDSASDTSSTASTGPSSPGMFSMPSASQPETKKPMSADSYSSASSKFPFANHGTNFPATFWDNSVREPSMDIPPPPMSGYNPQEVQQPKAQSIKGTIGDWLGLGVGMPSTSNNLWQLGPTYPDAGWSTETGSPRSPGQTANFYPATSNPWSFEDLPPPPAAQSPNSSWNSSSELFPSSIWSNPSSTNTSLLDTTTPSMATQESPQYSPFSSFRSLWGNPFSAMGNSGSSWSPGNNDQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4G9</accession>
    <name>A0A8B7Z4G9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450 4F12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110984150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099680.1">
        <property type="nucleotide sequence ID" value="XM_022243988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4G9"/>
    <dbReference type="GeneID" id="110984150"/>
    <dbReference type="KEGG" id="aplc:110984150"/>
    <dbReference type="OMA" id="QCLITRI"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022099680.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="57871" checksum="D16E308185BA5354" modified="2022-01-19" version="1">MATEVSQLTKLVSFLPANWCGVLFSLLSVSLLYLLVRFIQLLRWKQAFRYALRDFPRHPNGSWLLGDVPEYTKGHNGMGREFHFNYEEVTDAMQFWLGPFMPGVVVFSPETVKAVANKNEPKQESVMRFLQEWIGDGLVASYGEKWARNRRLVSPAFHYSGLRPHVNIFSECAHRLVESVRGTKCVRRPISHTNVRPDTYQCTYVSAVRKLADLFFKRFVTMWQYFDFLFYNCQDGKDFRRILKVALDFSKQVIIQRRSLAKESQKRAFRDLLDILIDARDDEGKGLSGDEIQNEVNTFMFGGYETTSTAATWALYCLAQHPEYQDICRKEVDELMNAKGSEHLDWTDMNCLPFLTMCIKESQRLYPTVPFVFRRLTEPLVLNDGRVIPPETTVYISMSGLHLNPTVWDNPQVFCPERFSPENSASRSPHAFLPFSAGPRNCLGQQFAMFELKTTFAILLRHFVFSADETKTIKLFNAGCLRSETGIHVVMIPRDKMDEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z573</accession>
    <name>A0A8B7Z573_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110984682</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110984682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100789.1">
        <property type="nucleotide sequence ID" value="XM_022245097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z573"/>
    <dbReference type="GeneID" id="110984682"/>
    <dbReference type="KEGG" id="aplc:110984682"/>
    <dbReference type="OrthoDB" id="10058436at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022100789.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="25000" checksum="E27FB10FFF6375C1" modified="2022-01-19" version="1">MGIILGIEAIVGIIEGAEAAAAAAEAGEAVAGAAEAGEAISAGAEAGAEAGTEAGTEAGEAVASGGEALSQILAKISVAMEKISKLVAEYEAINAVFKAADAILKDITSNPAARALAKKLANLIGVLVTCSSLMQDLYSWLKENANDTTTLQGFQVPLSGILSTFLPSLGAASGVLQSLSKQVAAENLRKDPVTSGEVEAIQKGLDTVAQSFQSLVTFKDQKASTVKALASMPIDNTQVAAITNQLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5Z8</accession>
    <name>A0A8B7Z5Z8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 4E type 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110983648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098766.1">
        <property type="nucleotide sequence ID" value="XM_022243074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5Z8"/>
    <dbReference type="GeneID" id="110983648"/>
    <dbReference type="KEGG" id="aplc:110983648"/>
    <dbReference type="CTD" id="317649"/>
    <dbReference type="OMA" id="HFYKSHQ"/>
    <dbReference type="OrthoDB" id="17977at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022098766.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24914" checksum="EE8027D22FC79154" modified="2022-01-19" version="1">MAASEIRQPQDPELRGFSDNSEDVDFQSISSAAGLEGTGVPLNTPWTFWLDRSIPNSTAAQVEANLQKIYTVSTVESFWAVYNNIPDVDRLAYRFSYHLMRNKIKPMWEDPSNASGGDWKFKVPKDQTGKAWKELLLATIGERFSSCISPDDEICGVSVSIRNLDVDIIQVWNRKAGLNDMEINKVIDMVKEILQGIEIKTHFYKSHQQHHAFEHGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z619</accession>
    <name>A0A8B7Z619_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Uncharacterized protein LOC110983661</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110983661</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098786.1">
        <property type="nucleotide sequence ID" value="XM_022243094.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098787.1">
        <property type="nucleotide sequence ID" value="XM_022243095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z619"/>
    <dbReference type="GeneID" id="110983661"/>
    <dbReference type="KEGG" id="aplc:110983661"/>
    <dbReference type="OMA" id="PIMETMS"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF188">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="269"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022098786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098787.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51974" checksum="03DFF71500590DEA" modified="2022-01-19" version="1">MSIFKEIPLDQTRSWTGFGVGLAVGVVAAAAVGYLWKYSKYRCNTDDYLQPGGVNTSQQLTILSRSSSRPVTPVHSLRSGDSGRGAAQHASPGSPHHDAARRHDGRLDVGRERGVEYTDNQGLLHLLYNMAEDQSRKESYVHRGISCNQCNASPICGNRFKCANCIDYDICERCEAHDRHNRRHVFIKIKIPIPPLANPRNALVKPFYPGKELQRRRLTLDEMQRLKSTTYFDQHEIEALFDQYRTLCTKDRGITRDVYDLCLGPIGLEKNLVMDRLFKFYDANGDGYIDFEEFVRGLSILIKGTPEEKVRYAFEGYDLDGAGCVSRDNLRKMFKAYFYITIELVRDVVKACEEEMMANFDDTQGRPVSSLFSAPIPTDTGPDPSQITKTPFPGNPGSREDMWPVMEAMSQDAIEEMVENIFRTANVDLDQRITLQQFRELTAVDSSLLAWFDALGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z749</accession>
    <name>A0A8B7Z749_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110984597</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100624.1">
        <property type="nucleotide sequence ID" value="XM_022244932.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100625.1">
        <property type="nucleotide sequence ID" value="XM_022244933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z749"/>
    <dbReference type="GeneID" id="110984597"/>
    <dbReference type="KEGG" id="aplc:110984597"/>
    <dbReference type="OrthoDB" id="6022714at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100625.1"/>
        </source>
    </evidence>
    <sequence length="659" mass="74505" checksum="39C4C7204EF4F3F4" modified="2022-01-19" version="1">MAAGSIVLMDSGLADLDKILQSLEIENRQQQNEIQKEQQEAAAFEAAVSEKEKSTKALQEDTARLDEETKAAHQQFCRNKETYESLKNHYLALELNQETAEKELHELQDKWQVEQLEHERLLRHYESVWEQYKAKYEEKELAVELRQWQHQVGGMRQRLNKSQHNVSLLETALQEKQEKKQNDPKPFESLADWIIQIAKAALRTRDLRRQKEEIQQSVTAAEAKIQERTEKRLQQQKEEEEQERKRKVEEEKEKIRQKELERQKQQQLNQQQQLQQLKAQQRQQQQARQQLQASVPTTPHQIIPPQSPLFQQPTRRALPQYLQSPLLGTAVARSSAVPASPQQLRQPPYLQMPILASPRPIAASANGRFENPSQQFTLQTRAESGNNNPQKQPESVIPQASDDLALKKTKSPPKNSTWNKIEESKLSTNQRATTSQDEPIRESQPFEVNQKESRETDDADTPPNEAPPTPADDPTSFEDPDTPGSVMSLPPRSPFDLDTHLQSLQEFAKSPGFSYSFRPMFGTESNESEVTEKPSSNVPTSSSDNFESPFFHSFFPGVGGANQQASDTPTQIFGSCSNQASPHLTGTSVFSRPDSPMDTSHSRPPGGILSLFGSGQDKVEERNDVDGSPASSCSFSFNFNGGSDSPHVDSSSEGKFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z981</accession>
    <name>A0A8B7Z981_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA repair protein complementing XP-C cells-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101365.1">
        <property type="nucleotide sequence ID" value="XM_022245673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z981"/>
    <dbReference type="GeneID" id="110985000"/>
    <dbReference type="KEGG" id="aplc:110985000"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.20.110:FF:000001">
        <property type="entry name" value="DNA repair protein complementing XP-C cells"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="2">
        <location>
            <begin position="346"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022101365.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46906" checksum="34246C9DC82ED88E" modified="2022-01-19" version="1">MCNNAEVQARALSQVPIHLVPRMPSLGTRTFELNWLLDVIEWFRATYFVNEHPSSDSATPIDALCSCIEKMSASKEQDQIHVCLTTFRALGLQARLIESLQPITVKYTAPSKVCSERASLQPHPQKQERISGVPTSKRSDKGKRKLLNTNSKSNSREQKRKWRRKRSRINDEIHKMKTRSCESTGKTWKIPEKSPYLDSEEDVQPKAEVLTEEFSSKRKVTNRNIVSSDSENDYRVLPSERRVCNSWIEVYSSKEKKWICVDFARGLINRPDLCEQNATKPICYVVAIDNENSVKDVTKRYASKWMYGTEKLRVHLNWWEATLKPYYTKLITRDKEEDDQLQKQLQDKPLPTSISEYKNHHLYVLKRHLLKYEALYPESATIMGYCRGEAVYSRDCVHTVSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9U7</accession>
    <name>A0A8B7Z9U7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101742.1">
        <property type="nucleotide sequence ID" value="XM_022246050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9U7"/>
    <dbReference type="GeneID" id="110985203"/>
    <dbReference type="KEGG" id="aplc:110985203"/>
    <dbReference type="OrthoDB" id="10045177at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="47"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022101742.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14743" checksum="1143C25E46C425B4" modified="2022-01-19" version="1">MTFTQVVGRSFSYPTQRLSYGMDTPVTKLPPDLFQRVCALLNNRHRNWKTSAGALGKDVETVAVLDSDRVANPTEQLLREWAMLDDKVTVRDFLEVLAEPVSPVDGYHSDSARQGRYTQTFSLFLVYLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAH7</accession>
    <name>A0A8B7ZAH7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Beta-parvin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110985732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the parvin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102658.1">
        <property type="nucleotide sequence ID" value="XM_022246966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAH7"/>
    <dbReference type="GeneID" id="110985732"/>
    <dbReference type="KEGG" id="aplc:110985732"/>
    <dbReference type="OrthoDB" id="2099265at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030031">
        <property type="term" value="P:cell projection assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071963">
        <property type="term" value="P:establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21304">
        <property type="entry name" value="CH_PARVA_B_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21306">
        <property type="entry name" value="CH_PARVA_B_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000015">
        <property type="entry name" value="Parvin beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000011">
        <property type="entry name" value="Parvin, beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028433">
        <property type="entry name" value="Parvin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114:SF4">
        <property type="entry name" value="GH23568P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12114">
        <property type="entry name" value="PARVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039131">
        <property type="entry name" value="Parvin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="120"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="9">
        <location>
            <begin position="288"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022102658.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46143" checksum="D39F0231C73C2B40" modified="2022-01-19" version="1">MDSAHVDVCTLASQNSKLFHERAAKILLTVKIWKMASSPTKTSTLKKEKKEESFLEKVTTLGRRKKIKDLKEVNDLNSDGRNALEAPASPVELTPDNFILENGEERSMIEPDSREDPKLKELIQVLMDWINEEMKEQRVIVRDLEEDLYDGQILGNLLEKLAGIKLEVREVMQSEVFQKQKLQVVLDTVNKLMSLPRWNQQKWSVDSIHSKNLIAILHLLVALAFHFKAPIRIPEYVSAKVVVVQKKDNLLVTNRVTEEITTTNEAIGGRFERDAFDTLFDHAPDKLNVVKKSLISFANKHLNKLNLEVTDLDNQFHDGVYFILLMGLLEGYYVPLYHYHVTPMLFEEKVHNVSFALDLMDDAGLPKAKARPEDVAQCHLKSTLRLLYVIFLKYKQGDNNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAU8</accession>
    <name>A0A8B7ZAU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110985310</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110985310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101940.1">
        <property type="nucleotide sequence ID" value="XM_022246248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAU8"/>
    <dbReference type="GeneID" id="110985310"/>
    <dbReference type="KEGG" id="aplc:110985310"/>
    <dbReference type="OMA" id="HRRAWHI"/>
    <dbReference type="OrthoDB" id="5984440at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF13">
        <property type="entry name" value="TNF FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="7">
        <location>
            <begin position="130"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022101940.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32649" checksum="65327D9D11F6EA26" modified="2022-01-19" version="1">MALSYSNSNIEACLVKPVLEKTAEAEDAISYTASTKHRRAWHIIQLVLHVVLFTAVIWLVVQVLHLQNELIQLNLRQSSKPGGDSSNFKGNHTMSSDSEGPRVRRQISHGDSIGMDSSYDYGYPGNEGFPSFHVTGIQQPVGGNWFTFHTSMDPAFSKYSHETLGFVHNKFFEVTMPGYYFVYSQICYKVNDLSNGHEVVVLPDCGDGVEFTILRAKAPQRTVDNGQTALEDTGYAGGVFYLAANDRLGVRPFPGQLVPLEYQDNVAQTSYFGAFLLTPDRHVEVDADLRRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBC6</accession>
    <name>A0A8B7ZBC6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transmembrane protein 214-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110985518</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM214 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102292.1">
        <property type="nucleotide sequence ID" value="XM_022246600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBC6"/>
    <dbReference type="GeneID" id="110985518"/>
    <dbReference type="KEGG" id="aplc:110985518"/>
    <dbReference type="CTD" id="54867"/>
    <dbReference type="OMA" id="NGSAGKW"/>
    <dbReference type="OrthoDB" id="10022292at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019308">
        <property type="entry name" value="TMEM214"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10151">
        <property type="entry name" value="TMEM214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022102292.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="75893" checksum="6456F3F4614D7C9D" modified="2022-01-19" version="1">MATFYTENVNKWETVSKKKKASASDKKAARKNFSNVAPTVDAAPPLKESETIFDAFSKKHNAQMSQMPPLAVPDSPSGKKAAGGDTQKKAAGSQQKKKKDPSRKGEKGFDSLAEALKALDPKELKAQLTEVQTRCPEARSLWLGDIVGFMNKKLLTKESDPVFSDQPPTYPLSKTSKHLLDFLNATLKSYNEDMLKAFFDYCIRELAGDSSKGQAAVNGYRVFIQLIASKNPEFVTNSMDHYLTMVKRKQNDKSHCLSVLWSCAQAGYSDPVIGLRVWCGLMLPLLGVKPASTYAMANLDRTLRQKMDKQKAHEVLGPNQFFPILDFVFTPGTALPAQLQKQLLKHYSKLKSIAFGTHPETTLRHFFPSLLARTTVNCPEQMKNELLNTLIICLSTDHHCFSKWRQMYDTHLLQSSVLMNHMLASWEKVQKQLPRQLLKETVRAFHLTNEDMASSRNGRMEHEQCKLACKELLERMSGFEFPWRSVLTAVVLALVTFVALDVYSHKGLHGSLTQAFFERSGISAVCKHTWTKISLYLGIAFDWASVNVPIYYVKAAELCGPYLVLLKDKLCALFLYLAELTTPLWAWLAHNVPIALELIKAQIPVLWNLLWGYLVLAWDFLSPYLIAFWAAVSPHLEALWDGILHYSVLLWTATLPYLKAGYQWLQQMLSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDG0</accession>
    <name>A0A8B7ZDG0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Myosin light chain kinase, smooth muscle-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110986262</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103710.1">
        <property type="nucleotide sequence ID" value="XM_022248018.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103713.1">
        <property type="nucleotide sequence ID" value="XM_022248021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDG0"/>
    <dbReference type="GeneID" id="110986262"/>
    <dbReference type="KEGG" id="aplc:110986262"/>
    <dbReference type="OMA" id="PWISTCT"/>
    <dbReference type="OrthoDB" id="10260894at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14103">
        <property type="entry name" value="STKc_MLCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000594">
        <property type="entry name" value="Myosin light chain kinase isoform-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="136"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022103710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022103713.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48922" checksum="951AB07DE332A42C" modified="2022-01-19" version="1">MPAEAPEPPANKPYAAKVFKDMINLVWPGTTYDGGSIVTGYVVEMCEDGKNNWKVLTKDVFSTSYAIKGLKEKCTYKFRVSCVNAVGTSKPSIISEPIMTSDAGVEDDIDEEDEPDEAAFEQRKVKVRKENVRDFYEIREELGKGKFGTVNKCVEKKTKKILAAKFIKAEKPADKKEVEHEIEIMMILQHPKLLQLYDAFATGNNMVMILEYVSGGELFERVIDEEFDLTEKEVTFFMRQICEGVKFMHASKILHLDMKPENILCVRKNSNKIKIIDFGLAQKMTKGLKVSCGTPEFLAPEVVSYDEVSFTTDMWSVGVICYVLLSGLSPFMGDNEGETMSNILKVEWDFEDECFDDISDMAKNFIENLLKADKGERMTAEQCLNNDWLKKEIKSTQSLSKARIKKYVIKRRWQKAINAVRAMIRVKGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE29</accession>
    <name>A0A8B7ZE29_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Actin-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110986388</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103909.1">
        <property type="nucleotide sequence ID" value="XM_022248217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE29"/>
    <dbReference type="GeneID" id="110986388"/>
    <dbReference type="KEGG" id="aplc:110986388"/>
    <dbReference type="OMA" id="ENMCISK"/>
    <dbReference type="OrthoDB" id="10300896at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000218">
        <property type="entry name" value="actin, alpha sarcomeric/skeletal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022103909.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="43003" checksum="CC081E2E9A5B7519" modified="2022-01-19" version="1">MEDMSALVIDNGSGMCRAGFAGDDAPQSVFSSVMGRPRSDLGCQMPGSPRDSYVGEEAQVKRGILDLKHPIEHGIVTNWDDMEKIWNHTFYHELRVAPEEHPLLLTDAALNPKANREKMAEVMFEKFDVYSLHIGIQAVLSVLSYGRGTALSVECGDGVLQIVPVYEGFILNKPIQRLDVGGRDLTNYLVDMLAERALDFSSSGDRETVRDIKEKLCYSTQNFKMELYNFRYGWNQDKNYTLPDGRVISVGSEMFRCPEALFQPSLIGLETVGIHEAVYKSIMECGMDTRRDLYCNVLLSGGSTMFPGFSDRLLKELEALAPQVMKIKVIAAPERKFMAWIGGSILASLSYFENMCISKEEFKEKGPAVVDQKCLDRVFPKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFD7</accession>
    <name>A0A8B7ZFD7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110986644 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104368.1">
        <property type="nucleotide sequence ID" value="XM_022248676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFD7"/>
    <dbReference type="GeneID" id="110986644"/>
    <dbReference type="KEGG" id="aplc:110986644"/>
    <dbReference type="OMA" id="THSCPRI"/>
    <dbReference type="OrthoDB" id="10024886at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039588">
        <property type="entry name" value="FBXO4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008:SF6">
        <property type="entry name" value="SI:DKEY-12E7.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022104368.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="44808" checksum="AE34645814261698" modified="2022-01-19" version="1">MAETNRKTSGRQRRGLRNKSSQTMKRKKTQKDQKRDDVFPFGDLPEECRLKILSYLTDKEKCTAALVCTSWTNLIRTPCLWTKANFVDLLYRQKNKPFPIPSPTLECQVLKERVKNFVFHLVSRRALLRELKFEFDLHEGDEIWLKLVVYLLQMTHAQELHTIQFNWTYTPHVPWFLSGAAVDAKESRVTSFHKLLMVLKDTSRGVQGFTMPFDWSPYSVTLLCQFKCITTLELSKYWVFHGLPQRLLNKLLQELPKLRRFKLEVAVPFRDSESYPQYTMSSGTLEELDIAACSGFFLWSVTLPNLRHFWESRTAWSGPILPRKALKIHCLYDVMRHGAPKLKFFNTCPLWEGWRGSCPSKLEDVLRVTCYCERHKSSPLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZG49</accession>
    <name>A0A8B7ZG49_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110985481 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110985481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102221.1">
        <property type="nucleotide sequence ID" value="XM_022246529.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102222.1">
        <property type="nucleotide sequence ID" value="XM_022246530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZG49"/>
    <dbReference type="GeneID" id="110985481"/>
    <dbReference type="KEGG" id="aplc:110985481"/>
    <dbReference type="OrthoDB" id="9836384at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36867">
        <property type="entry name" value="MCG131172, ISOFORM CRA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36867:SF1">
        <property type="entry name" value="RIKEN CDNA 2610318N02 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102222.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42392" checksum="E93D758B704A1996" modified="2022-01-19" version="1">MEEYSEFDQPQTMSRAFCMQIPASEYDAQGATETEKALRDLMDYLEKNPAVYKKVLVRRKQEEAENAGVLSYVKCKVLAAVKGPDYMEEEVSNQETLHKIGQLQYELAKAYDYAQEANKSKKRFSRRIAAKKAQASKNKENTTPANFKKPKTASSNSKCKAPPPPSYPPPSISSPLTSEDDEVFVKFNLPITPCRRPSIHRHDSTSSIDSSIPPPPPPPPPTPANMKSNKILKERTNAKSQVSFESPIYKSTPNKPPLTPKPPLTPGIHPNLKRHGSSTSLSSIASVHEELISFDKSRLRAVSTNRSPRSIPFKTPQSRKRVLSASVVRASITDICGISTISAFNQQMVDKFRNARSPVTVVNSPASGFNSPESGFNSPTGFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZH34</accession>
    <name>A0A8B7ZH34_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Protein hunchback-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110986903</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022104890.1">
        <property type="nucleotide sequence ID" value="XM_022249198.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104899.1">
        <property type="nucleotide sequence ID" value="XM_022249207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZH34"/>
    <dbReference type="GeneID" id="110986903"/>
    <dbReference type="KEGG" id="aplc:110986903"/>
    <dbReference type="OMA" id="EESLMYV"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZINC FINGER PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="123"/>
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        </location>
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            <begin position="145"/>
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            <begin position="174"/>
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            <begin position="202"/>
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            <begin position="233"/>
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            <begin position="627"/>
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            <begin position="1"/>
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            <begin position="1"/>
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            <end position="447"/>
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            <end position="519"/>
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    <sequence length="686" mass="76090" checksum="2EE9A601CB7F26E6" modified="2022-01-19" version="1">MDEEYQQSSVDNDAVAEPVADPPVSLLQSGDPEVTTLPSQQLTTPCLSQPSEATVTFPPSCSTSASFSSSYLRQGVDLTALTPGDMPSGFGGDMAHKCVKCSSSFNSSYELSIHWQEEHRENYKCKRCERCFAKKHNLLRHNCVNACNICGQQFTRRYNLKLHMQVHGDGSKMYKCEYCGKSFTRRYTLLTHTRSHSGIKLFKCSICGKAFTRQHTLNLHLKRHVQGQSKASFFCRKCYAVFNDAVSLQLHRENEHSKAKKEQTVQNSAMSQAVQSSANVVFPNNCAGYIYGTENVSLPESYHVGPYYQQEDVSQLQNIQRDGSSSNPNIEQGSFNDSKDNSLMLEKSRHPASLEKQHWFNEKDDSQDSSPGQHDPPALEENSAVQGSSTNIVTVVDSEDEALKEPQCSNELVDVSQGTIGLDDSGCGSEVHVTVGRDTEPVEETRRSLFPMDNSKRDKRMGHRMHRPFYSGWKHGDRMVKETSEIRIDIVDPNSLEEINPPLTPPRSSDTSTPRLNQASSESGSPSTASILEMSPTYTSQHHASRMKQSQGATAGVSQNKSCSSSRLPSQEQPALHKNTAYRSGDKMHSALQPGGNSSDCSSSEMAAQHIAKHSKDNPDGDVDTKWRCAHCGITFEESLMYVVHMGCHGQLDPFQCSMCGLKCLDRMAFTLHIIGGKHIHVRPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHK5</accession>
    <name>A0A8B7ZHK5_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">Fucolectin-5-like</fullName>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Asteroidea</taxon>
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            <taxon>Acanthaster</taxon>
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    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="Galactose-binding domain-like"/>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
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        <location>
            <begin position="29"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105064.1"/>
        </source>
    </evidence>
    <sequence length="159" mass="17037" checksum="DFBF03B128ED1BCC" modified="2022-01-19" version="1">MLRESRMLQSVAAVVLALGLAGFSLVTAFNGDQVEVLERVLDVNAEEVKKSAATNSQWWKVDLGKGQCISKVTIHYLGESCSESLKDAFVVAGTGTTTFENQPCGAPITASQARPPGGSILRDCRRPIWARYVYIYILVPATSMQGCEGSVDALSGPHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKS8</accession>
    <name>A0A8B7ZKS8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-amylase</fullName>
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        <name evidence="19" type="primary">LOC110987240</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
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            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
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            <taxon>Acanthaster</taxon>
        </lineage>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
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        </reaction>
    </comment>
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        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_022249798.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pancreatic alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034074546" description="Alpha-amylase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="17">
        <location>
            <begin position="27"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="16">
        <location>
            <begin position="412"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022105490.1"/>
        </source>
    </evidence>
    <sequence length="716" mass="78418" checksum="BC0A3C6B8BDD2018" modified="2022-01-19" version="1">MKILCLLALLIGSAVGQWEPNTAYNRQVIVHLFEWKWTDIAEECERYLAPNGFGGVQISPPSEHREVWSPWRPWWERYQPVSYKLTSRSGPESQLRDMVKRCNNVGVRIYVDAVINHMGAGDSGTGTAGSWYDVGTLSYPGVPYSSLDFNVPNGKCNSGNGDIQSYQDVIQVRNCNLVGLPDLDISKSYVRSKIVGYLNELIDIGVAGFRVDACKHMWPGDLNALSGSLNDLNTAYFSVGSRPFIFQEVIDQGGEPITAGEYTAYGRVTEFKYGLRLGEAMRGYNKLTYFSNFGEAWGMLADTSALVFVDNHDNQRGHGGGGNIITFENPRLYKMANAFMLAFPYGITRVMSSFYFNHDTDAGPPADENGNTQSVTINADGTCGNGWVCEHRWRQIKNMIGFRNVAAGQPLSNWWSNGNQQIAFGRGDKAFIAINNDGHTLSETLYTGMPSGEYCNIILGDFDSSSGSCSGPTIHVDGSGYAYFNVDTGDDPVAAIHTKAKVGDSSGSPVNPIDHINPGNPTGSQRTVIFIKKHTIIGQDLFIRGGIDHTKRGGCTSNADTSACALPIHHNIGGTNTKFNAWKSGDDFLDWYGAESDQSSYEGRTADGTPLVWTTNNPTNGGNVEADGYGYTPLNKWGDHYWMVDLNVDCDQTEAGWFEIKAYLKNGAGWESDIWQGSCSGSAGGSKPYSSNNHFARCGYLNMFDFGSNSCTIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMA2</accession>
    <name>A0A8B7ZMA2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987533 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106020.1">
        <property type="nucleotide sequence ID" value="XM_022250328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMA2"/>
    <dbReference type="GeneID" id="110987533"/>
    <dbReference type="KEGG" id="aplc:110987533"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106020.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="55769" checksum="83FC9592D854E952" modified="2022-01-19" version="1">MDLNPDADLAVRKKKKKKKKRKHAETPADYAWIKTEPETEWLSVQSQNLDFGTIDNNRTLGAPKETRKKKKKVKSEDPVENVPSVDAEMVCDFGISDSTDHSDEAKQILKKKRKRKRKRSILQEAQSEETSSIAGDSQQEVQDGVEDCPLSFRAEPQSHKCKKNKKCKVQEQPSPGTLTADVAESQHIMPAVSEATKEKVADKSRKKKKHKAKDHLDSPMSTDADGDQTSGKITVTDTTEDDARHKKRKRKAQDKLNELHYEEPQGLADANCKNQDDLVSEGVGYPVRIKKGKRKKKDLDEHLQTGGSAESQISPNTVDMQEKLSSQEEDPKPRKRKKKSTGWNNGNDDPICLQSSEIEIGQSGCSKAPAADRLLEAKASVFAGKMGWSSAAEEEDESWIQDLPFYVGTSTCTSLRRKPIQKEGVVLKKGYWKGHEDKILRENIENFCKGETGSSTWLHLHLRHHPLFYLPDVEVLGSIISHMYCHPSVETMCHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNK0</accession>
    <name>A0A8B7ZNK0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vicilin-like seed storage protein At2g18540</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106475.1">
        <property type="nucleotide sequence ID" value="XM_022250783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNK0"/>
    <dbReference type="GeneID" id="110987753"/>
    <dbReference type="KEGG" id="aplc:110987753"/>
    <dbReference type="OMA" id="AMAMSPC"/>
    <dbReference type="OrthoDB" id="10636177at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106475.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20710" checksum="B231F198313C3F96" modified="2022-01-19" version="1">MARGLEKGGERTKGEKGKGKAPAAKTRDTAFLYEDEKLKMRAAIRASMKEAGIGMSKVYRVVAETSSSDEEEFLDRHVADAMAMSPCMAAMMEGEQTGEEAEEETRGDERRQERRQERKQERRQGRRKGERRQKTGRSLEERRREEEIMKAGEETTADETEAAGPSRGKKKEKRRRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPM2</accession>
    <name>A0A8B7ZPM2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ficolin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107533.1">
        <property type="nucleotide sequence ID" value="XM_022251841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPM2"/>
    <dbReference type="GeneID" id="110988391"/>
    <dbReference type="KEGG" id="aplc:110988391"/>
    <dbReference type="OrthoDB" id="7940501at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034459140" evidence="1">
        <location>
            <begin position="26"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="93"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107533.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39413" checksum="9C32D054748CCB64" modified="2022-01-19" version="1">MVQRLSWAPLAAVVLTIAGLHEVSAKVCYLSQEPDPSHNWRLRWLIQGTQENCICTSIRVGGVNLRFQQQQSYKPYLTDNPLFTTDVEKIRDYFGCNYPADCQEWLDAGYNTNDVYTIYPMQYQNGLQIYCDMKKNESRWMGLQGGWIVFQRRQDGSVNFTRSWAEYRDGFGNLTGEFWLGNEYIRQLTGEGRWELLVELLVRKATTSLARYLMWYRTFNITGEQYTLHVGGYDTTLHLTVCDVAQCRSGGDSLTTKHNNQDFSTYDRDNDNDAGNNCAEKYSGGWWFNKCHSVSAWNPDVTSNLNGEYSTARGGSANPSFLRWKGVGPSETIYTSEMKMRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPW2</accession>
    <name>A0A8B7ZPW2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Paraoxonase</fullName>
            <ecNumber evidence="8">3.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988044</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a phenyl acetate + H2O = a phenol + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140310"/>
            <dbReference type="EC" id="3.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="6 8">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the paraoxonase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.2" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022106945.1">
        <property type="nucleotide sequence ID" value="XM_022251253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPW2"/>
    <dbReference type="GeneID" id="110988044"/>
    <dbReference type="KEGG" id="aplc:110988044"/>
    <dbReference type="OMA" id="KHLNCHY"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004064">
        <property type="term" value="F:arylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002640">
        <property type="entry name" value="Arylesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF12">
        <property type="entry name" value="PARAOXONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01731">
        <property type="entry name" value="Arylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01785">
        <property type="entry name" value="PARAOXONASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="In form B" evidence="7">
        <location>
            <begin position="44"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602640-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022106945.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="42027" checksum="F878701FDFF2AE8B" modified="2022-01-19" version="1">MFRPTWMKRIFIGITAVLVLQHLLSIVYSLGFHKQAYNHRPGMCRVVPGIDTGSEDIYVLKNGLALITSGMNVAALGFTMDPSALTWRGHIYLFDFNQPNANVTELSILGSFDQTDFRPHGISVWEERTQTTVFVVNHKHQHDSIEVFSFNEKMKSLHYLRTFTDSRMTSVNDVVAVGTNTFYFTNDGYNKQFFKRFLERFLKFPWGNVVYYDGNTGWGQVVIPRSLEPNGINQSPDGRFIYVSSPVVGALTVYERQPDYSLKPIQVIDLYTSPDNVYVDSSSGDLWFGCHLISYQTMLHFQDFRQPSASQVLHIQLKSKTAPYSYDIREAYVDDGKQISGSSVAAYYNNQLLIGSVTHKLVHCQVLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQ19</accession>
    <name>A0A8B7ZQ19_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane prolyl 4-hydroxylase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110988472</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022107683.1">
        <property type="nucleotide sequence ID" value="XM_022251991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQ19"/>
    <dbReference type="GeneID" id="110988472"/>
    <dbReference type="KEGG" id="aplc:110988472"/>
    <dbReference type="OMA" id="VIWYNHF"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034674008" evidence="9">
        <location>
            <begin position="35"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="285"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022107683.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="49757" checksum="E9C8FE1E5F222885" modified="2022-01-19" version="1">MERCSVRNQRRQSALARWSRTLTLLLAVLFGSLAVLPSETSSNVDSSVESDSAGDHEDRTNLYKKPDGESDVTETCPRESGGNLAGSEGACPGKSRLVRLEGEKVGHIEELQLVQGKIHQLKTINMKPVIFEIPDFFTREECNHIITLAKEQGLESSLTTSTGKGKGLTLRDSNGDQKLSLREMQMTLEDGFDIYLDDDDIRQMYAELGVDLNKDGFLSRQEVDGETIRKISSYVMKVEEEQPIKKSRFSEQTWIYPDKTEDPLVQSFQDRIAKLTMLPRVLIDKFSYFQVVHYGKQGHYNAHHDSSYLDDSSTCCHLTESKQCRICRYMTIMVYLNNVAEGGETAFPVANNDTYNAYVFRQTGMMNLNTRCQDSNLKVQPQQGKAVVWYNHFINASTGWLGDVDPLTWHGGCPVTKGHKWIMNRWIAVSESREVDLAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZR36</accession>
    <name>A0A8B7ZR36_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, CUB and EGF-like domain-containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108038.1">
        <property type="nucleotide sequence ID" value="XM_022252346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZR36"/>
    <dbReference type="GeneID" id="110988629"/>
    <dbReference type="KEGG" id="aplc:110988629"/>
    <dbReference type="OMA" id="HECTECP"/>
    <dbReference type="OrthoDB" id="6147614at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052071">
        <property type="entry name" value="SCUB_EGF-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046:SF5">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24046">
        <property type="entry name" value="SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="1">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108038.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37046" checksum="D48E2EFEB22F0FE7" modified="2022-01-19" version="1">MCSDMDIYNMYFQFLDESILAFSVSIPLSLEGCRQVTRPFRGNLVCQIDGQEQNCTISCWQGYSFSRAVLPSYQCGASTNYKWSHETEDNPRLALPQCTKYKPPNKIAMVMNLAYSTNLTCDGFDPARDSLVHQTVRDKITLNVKTLSCVQDNSCSVKRAQVSGCSTQSPADQTHRRRRRSVELIQITIRLERDIHVPDQQNLTSEQVTNQNSTIEAVSELQDAALQLINKSASGQFALNVDHQVYDVDTERTQAYGMQVCPHGSVRMNAQDARCVPCESGWYENKEACYACPPGTYQSQEGSIYCQDCPRGHTTIGPGATEEEDCEVIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZR76</accession>
    <name>A0A8B7ZR76_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022108078.1">
        <property type="nucleotide sequence ID" value="XM_022252386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZR76"/>
    <dbReference type="GeneID" id="110988651"/>
    <dbReference type="KEGG" id="aplc:110988651"/>
    <dbReference type="CTD" id="3093"/>
    <dbReference type="OMA" id="THLRGQF"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022108078.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22222" checksum="7887ADD564A16C1E" modified="2022-01-19" version="1">MATIAASRIKRELREVKGDSELIKDDVILDLIDDKSYLALTGEIPGPRDTPYEGGTFHLKIIIPETYPFNPPQVTFTTKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSVQALLSLPEPDDPQDAVVAQQYKDNPDAYQKTARHWACAYAGAKCTNRELDEKIEKITEMGFGESTARDALSATDWDVARAVDRLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRK3</accession>
    <name>A0A8B7ZRK3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">G protein-coupled receptor kinase</fullName>
            <ecNumber evidence="9">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110987558</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022106066.1">
        <property type="nucleotide sequence ID" value="XM_022250374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRK3"/>
    <dbReference type="GeneID" id="110987558"/>
    <dbReference type="KEGG" id="aplc:110987558"/>
    <dbReference type="OrthoDB" id="354826at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004703">
        <property type="term" value="F:G protein-coupled receptor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01240">
        <property type="entry name" value="PH_GRK2_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000118">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000084">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000068">
        <property type="entry name" value="G protein-coupled receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000239">
        <property type="entry name" value="GPCR_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355:SF18">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24355">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00717">
        <property type="entry name" value="GPCRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RGS" evidence="13">
        <location>
            <begin position="54"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="191"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="454"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="555"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600239-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022106066.1"/>
        </source>
    </evidence>
    <sequence length="689" mass="78928" checksum="F827C280479946BF" modified="2022-01-19" version="1">MADLEAVLADVSYLMAMEKSKSTPAARASKKIVLPDPSIRSVMYKYLEERNEITFEKIFKQKLGFLLFKDFCENVSEVPVPQLEFYEEIIEYEKLDSEEERLKRARKIFDNYVMKDLLSSSHPFSNEAVESVRQSLIKREVPTDLFKPYIKEIMNSLSGEIFQKLLESDKFTRFCQWKNVELNINLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGESLALNERIMLSLVSENDSPFIVCMTYAFQTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEVQFYATEIILGLEHMHNRSVVYRDLKPANILLDENGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLSKGLAYDSSADWFSFGCMLYKLLKGHSPFRQHKTKDKHEIDRMTLTMDVEFPDSMSEEMRSLLEGLLQRDVPMRLGCQGGGAQEVKDHAFFKGIDWIQVSYQKYTPPLIPPRGEVNAADAFDIGSFDEDDVKGIKLAESDQELYKDFPLTISERWQEEIAETVFEAVNGDADKQEAKKRAKKMDEGEYAMGKDCIMHGHILKLGGPFLNSWQKRYFYLFPNRLEWQGDGEKGVSSQNVLVMEHVLSIEETMVKGFKCIQLKLKAGKNCILRTESDPEYIQWKKEIALAFDTAQQMLRHGPKMLATQGSSSDIMRHQPLGQRNSNGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRM8</accession>
    <name>A0A8B7ZRM8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022107535.1">
        <property type="nucleotide sequence ID" value="XM_022251843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRM8"/>
    <dbReference type="GeneID" id="110988393"/>
    <dbReference type="KEGG" id="aplc:110988393"/>
    <dbReference type="OMA" id="AHSMPQT"/>
    <dbReference type="OrthoDB" id="10059453at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="109"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="717"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="755"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="820"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107535.1"/>
        </source>
    </evidence>
    <sequence length="869" mass="97006" checksum="375A6CA669CB1708" modified="2022-01-19" version="1">MNKKSTPSKAGMTYRTNSRKNGWSCPPHPLQFVAWIFIAFFAVMFHGMAVPTIPYHWQPACHMIAGVMLAVHVLTHLVCLTINPADPNTLRKHKKVMPTFDRTQHKHVIENNHCYLCEVDVGLKSKHCSSCNKCVADFDHHCKWLNNCVGSRNYRWFISCLCTAFLCCLFVFAVFLYISIVYWVNPRLLHPELFDNAATTQPTVTTDESMSGQILNNSTSPSPDNSDPLLAYRTGLRIFAEVSGIAFFVVAIVMAVLLFVTLCLLGHLLGFHLYLICKGMSTYDYVMQDRNAFISGDVESQQQRPRKKGCCKCHNQVAPLPEAKEEIELTDTKKDSTTRQLESNNNSNSNLQQQLVISEPLIKQELQQQQQNSIPVTDSKPKPKKKKKSKKKPHHLRSLTARESLQPALMGHPFPSSQMNLAHSMPQTYLEQHLVRRFSLPLVTPAGMHPQYPPSEPVEDLFFTQQFPTMRRPVVSSHDGQPQQHPIPVPAAISFDSPTPALDYHSSSAESLVEIPIGRVHHRGSLSNPTQTAVLPGGGYQLAAAYPHPLEKWQLNHSSHPNLMMNGNQWQPDMKQFGRGMNFSGSNVNGITHVKKSKRTSARTKKEVTGIRPLNEIERERKDSISEPLLVENSQGATLHQVPNSDRLDGTPGENAKKRTKKQKLPTAMETTAEVHRELDNHLLVGQHSSSDSWKKDVQGVNQDAQILETQDAHFEHCSQETAQPEARTRSKQLPLQSLPVAAPRRRMLKLGPESSGSRTSLQTSSSQQHLLEGADEGCGPPSGRSRKEEQQEPQDDSSHDLVSLPGSIPEVPPLDLSPLTGTMDSNPATVTQREPSEGGSISDAQLVEGYSAKEPRPVSSRRSLLLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZS54</accession>
    <name>A0A8B7ZS54_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat domain-containing protein 40-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108403.1">
        <property type="nucleotide sequence ID" value="XM_022252711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZS54"/>
    <dbReference type="GeneID" id="110988829"/>
    <dbReference type="KEGG" id="aplc:110988829"/>
    <dbReference type="OMA" id="CSNQQIL"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039195">
        <property type="entry name" value="ANKRD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24192:SF3">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108403.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27212" checksum="03408580942B35CC" modified="2022-01-19" version="1">MDDSKDLEDKFREAASIGDQDMLDKLLQLGVNVNAQHRINGWTALHWASKRGHPTIVRHLLTNGADRSLTNGKGETAAQLTDKEEIHSLLGGKPETLSNSSLPITPNYIRHPPFPYLSKTNGTAQSPMANTNHDQPITSRISHLSSEELVLKVRVANSAETDFIEIEIDRNERTFSNLVLTCCRELNCEPETVVKVRKLPNTILRKDKDVWRLTDFQELEIVLQKFSGGTRLQNAFQELIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTN7</accession>
    <name>A0A8B7ZTN7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cyclosome subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">LOC110988697</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. May recruit the E2 ubiquitin-conjugating enzymes to the complex.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. Interacts with the cullin domain of ANAPC2. Interacts with UBE2D2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RING-box family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108169.1">
        <property type="nucleotide sequence ID" value="XM_022252477.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108170.1">
        <property type="nucleotide sequence ID" value="XM_022252478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTN7"/>
    <dbReference type="GeneID" id="110988697"/>
    <dbReference type="KEGG" id="aplc:110988697"/>
    <dbReference type="CTD" id="51529"/>
    <dbReference type="OMA" id="QWRWDTG"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000111">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022108169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022108170.1"/>
        </source>
    </evidence>
    <sequence length="84" mass="9922" checksum="E30BF3C61E1EF564" modified="2022-01-19" version="1">MKVKIISWTAVSTWRWIANDDNCGICRMAFDSCCPDCKMPGDDCPLVWGQCSHVFHMHCILKWLNSQQVHQQCPMCRQEWKFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTV9</accession>
    <name>A0A8B7ZTV9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110989151</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022109003.1">
        <property type="nucleotide sequence ID" value="XM_022253311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTV9"/>
    <dbReference type="GeneID" id="110989151"/>
    <dbReference type="KEGG" id="aplc:110989151"/>
    <dbReference type="OMA" id="NHRTELY"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000004">
        <property type="entry name" value="Glycoprotein 3-alpha-L-fucosyltransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF145">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="101"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022109003.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="36315" checksum="E1013407D9ED8675" modified="2022-01-19" version="1">MELTIADGRRDFAGMDAVVFRFTRGLVPWRPLPADKNPGQAWVCFSWESPSSMVQEDRVAELPVHATWTYYRGSEITTPYGFYKPGKPVSSRRKPAHEWVKGKTRLIAWMSSNCKGTFWPRTDFVRELQRYVQVDAYGTCGDLKCQPAWSAKCNRDLLREYKFYLSLENSECEDYITEKLWNKPLLQGVVPVVYGPRREIYEELLPPNSFIYIGDYKNVKELADYLKVLNHRTELYAQYLQWQYRGSVEVLKPMHGSYDPSIFCNLIPVIRRVKRGEMKRRPVKESSFAHSCRSNETFDSNFGLDNWNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVF1</accession>
    <name>A0A8B7ZVF1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Tyrosyl-DNA phosphodiesterase 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110988374</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107496.1">
        <property type="nucleotide sequence ID" value="XM_022251804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVF1"/>
    <dbReference type="GeneID" id="110988374"/>
    <dbReference type="KEGG" id="aplc:110988374"/>
    <dbReference type="CTD" id="55775"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09193">
        <property type="entry name" value="PLDc_mTdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09195">
        <property type="entry name" value="PLDc_mTdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBZ-type" evidence="13">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022107496.1"/>
        </source>
    </evidence>
    <sequence length="674" mass="74552" checksum="7082C0BB4CDBCE10" modified="2022-01-19" version="1">MNQVEADEIIAKRLQQQLDAELAHSMQDHQHQGKYSAVDDRSDHMSDTDSDATYIEEEGVVEGQPGPTEFPTNQRASEAVALKRSVTGHDISDSDSESPDETSQSLLGRKKSNASSSSASSSTAATRAADSRVTTSVRKTKEAPPDPSGNPSNSLKPRCNYGGKCYRKNPSHRMEFRHSDEDEEGLPPSKRLRRDDGSASSSTSPATSASKKTCLEITREASPLCFLLTKVSGIPEKYNSSLAVHISDILSPCMGDLIASAQFNYMFDIPWLVQQYPTQFRSKTLLIVHGEQRQAKAALHEAAHPYSNIKLCQAKLDIMYGTHHSKMMLLLYTSGMRVVIHTANLIDRDWHQKTQGVWISPIFPKVDPSTTGADSPTSFQRDLAEYLTAYRSPSLQDWIGHVRGHDMSQAKVHIIGSVPGRHAGGAMHKWGHMKLRQVLKDCGPNEADVRGWPVIGQFSSVGSLGPDKDKWLCAEWLQSLSRCQGSGRKMQGESGSKTLKLIFPTKDNVRTSLEGYPAGGSIPYSIKTAKKQLYFSSFLHQWNASTRGRSRASPHIKTYCRMSPDSEHIAWFLVTSANMSKAAWGALEKNGQQLMIRSYEIGVAFLPADFVSGSTKFAISQPPASSSCDSNELHFPLPWDTPLVPYSRDDRPWLWDIPYTDLPDSHGNCWVPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXM5</accession>
    <name>A0A8B7ZXM5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein LOC110989821</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110164.1">
        <property type="nucleotide sequence ID" value="XM_022254472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXM5"/>
    <dbReference type="GeneID" id="110989821"/>
    <dbReference type="KEGG" id="aplc:110989821"/>
    <dbReference type="OMA" id="IMELCCE"/>
    <dbReference type="OrthoDB" id="6141694at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF29">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022110164.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="34905" checksum="298F532EF5B2F5EC" modified="2022-01-19" version="1">MELKSVKTELAILEAEHSMMISEKLELRRDVPGRPYTNDVDKCIMELCCELNVPTTKVGEVIGAVCRHIFKKDNIDNLPSASTANNMVDQAHVLSKLQMAEGIIGSERWDLHGDGTSRDGKKILGQQVTLNSGKTLSGGFSAVAVEDGVTLLDNIIAMMEELSDLYGGEEKEEVYKKMKKMFATMSDRSSVNKAFNNRLESYRASLLGDKSVGLHFLYCNAHFLLGLSNNCEGVLKELQKDLVNEKGQGIGRDAEVKFGRFSSSGESAAARYIRTACDVLGPRGDQKNGCRTKWVAFCSETLGVNSEVSSFRMNLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXV2</accession>
    <name>A0A8B7ZXV2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">D(2) dopamine receptor-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110989484</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109580.1">
        <property type="nucleotide sequence ID" value="XM_022253888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXV2"/>
    <dbReference type="GeneID" id="110989484"/>
    <dbReference type="KEGG" id="aplc:110989484"/>
    <dbReference type="OMA" id="THFQLDN"/>
    <dbReference type="OrthoDB" id="10010417at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000523">
        <property type="entry name" value="5-hydroxytryptamine receptor 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000929">
        <property type="entry name" value="Dopamine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00242">
        <property type="entry name" value="DOPAMINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="61"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022109580.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47648" checksum="65B07EA80E3877FB" modified="2022-01-19" version="1">MSAPAKIEMSVSYTHFQLDNRGSPNLWNLTNTTNFQQKNKSATLNLPILLLLVLIIWTFFGNVLVLIAVYRERGLKSMSNYVIASLALADLLLAVLVMPLGLVSLVRGHWGFGLPLCVIYLALDVMLCTASIIHLCAIAVNRYLAVTFPLHFSRERVNSRPRILGTIVPVWMVSLAISIPLFVQGFLDPDSTLQNEGRDCGYFNSTFIVYSSMCSFYVPLAVMIVVDWRAVRKLRGRKKAVEFGEPSPRTPIQQVNSNSTTVSCGDSPAHDNPTANGSKSVDAIRKRSLRITFCAGVKKSSVGYGSTQTEAIKTRQRWMTSKRERRAAKTLVVVFVCFIVLWLPFFVVHLLSGVCSSCHPPNELFIVFTWLGYISSAVNPCIYTCFNLDFRRAFMRIITCDKHPRRVSRHADLTTTHTLRTSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY04</accession>
    <name>A0A8B7ZY04_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aquaporin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aquaglyceroporin-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110989506</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea. Also participates in cell permeability to H2O2 and H2O2-mediated signaling. In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair. In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer; each monomer provides an independent glycerol/water pore. Could also exist in other oligomeric states.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109635.1">
        <property type="nucleotide sequence ID" value="XM_022253943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY04"/>
    <dbReference type="GeneID" id="110989506"/>
    <dbReference type="KEGG" id="aplc:110989506"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023275">
        <property type="entry name" value="Aquaporin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF29">
        <property type="entry name" value="AQUAPORIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02015">
        <property type="entry name" value="AQUAPORIN3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022109635.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="35559" checksum="D8F9E66D346314C0" modified="2022-01-19" version="1">MANTEDTQLLSADRPGSYLNGDSIQSHSGSKSKMSEGWFTHVDKFLDNLRLRNELVRQFFAELLGTFMLVLIGDGAIAQMQFFGGTALGAGFLNVNIGYAFGLMLGVYFTASVSGGHLNPAVSLAFCTLGKLRWIAFPVYMLAQFIGAFLAAVMVFAVYYDAIDKHDHNRTVVGGTAGIFATYPKAELSWGVGFVDQLLGTALLMAGIMAVTDNKNSKPPNGLEPIFVALTFFAVGISFGYNFGYGINPARDFGPRVFTAIAGYGSDVWTLNGIQWWIIPTFVPFLGAPVGAWVYYLAIGMHCESPHRGQGDHAELLEAQAPDAAEKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1Q1</accession>
    <name>A0A8B8A1Q1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110990299</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with DDX4, PIWIL1, RANBP9 and TDRD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022110895.1">
        <property type="nucleotide sequence ID" value="XM_022255203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1Q1"/>
    <dbReference type="GeneID" id="110990299"/>
    <dbReference type="KEGG" id="aplc:110990299"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071546">
        <property type="term" value="C:pi-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09521">
        <property type="entry name" value="SAM_ASZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042650">
        <property type="entry name" value="Asz1_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24157:SF3">
        <property type="entry name" value="ANKYRIN REPEAT, SAM AND BASIC LEUCINE ZIPPER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="9" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="17">
        <location>
            <begin position="333"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="41"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022110895.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="59710" checksum="6B9037C80566EDBE" modified="2022-01-19" version="1">MTGMAEHRLGFTSAFPAGTEDYSDDEDGLCIIDGNALSNMNQQPSSANVPEWDTVGSVKSSTETPFQDNDRSLEGGRNAESSANSSTKRDRQGFPIILDDFRKAVCRGNLQDVEAFRLQGVPVDTSLRAGWTALMYAVFYGNTQIAEYLVQEGADVNFNKASYMYTPLIAAASSEQEKGHVTSCLTILLEMGANPNVHERSHMTPLMFVAKNGNMDAVQKLIDFRAETDRQDNRGWTALCYAANQGYTSVAECLLNAKADAKKRCSEGTARDIACSHGYIELTELIERSMSSGRTNDETPHPEQHSFLSPSRSVSMQPTTSLSINLTSSASGEACDDLDLFLCGLDLGHLSPCFRQHAVKFSVLLQMSEADLEKIGIDKYGWRHKIMDAVHEIHKRNWEPGSVQASGKRILSHSESIALIKNVTKHVAYIGSSIMYMGSNWKAHGTLFDELQDPANLQRLMIETDEGLEQAVRLFNEVRKLKGQLNQVTYSKEILPADLIYEPEDTPRIGRGLTAIFTVAVVTTSVFILFRNSFLQTVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3A8</accession>
    <name>A0A8B8A3A8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110989953 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110371.1">
        <property type="nucleotide sequence ID" value="XM_022254679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3A8"/>
    <dbReference type="GeneID" id="110989953"/>
    <dbReference type="KEGG" id="aplc:110989953"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022110371.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="12159" checksum="98BFC65CAE9F6239" modified="2022-01-19" version="1">MQSGLRRMQWSKTRLAGTEVYRSFHEDDGARNGRCVGSISRESRTDSLDEFSHIENDEDDSDVSRSTDSEISKRRRNSSFSADYGNSDPDSDEELEQWMEITAGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A4S8</accession>
    <name>A0A8B8A4S8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Lysosomal-trafficking regulator-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110990316</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110934.1">
        <property type="nucleotide sequence ID" value="XM_022255242.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110936.1">
        <property type="nucleotide sequence ID" value="XM_022255244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990316"/>
    <dbReference type="KEGG" id="aplc:110990316"/>
    <dbReference type="CTD" id="1130"/>
    <dbReference type="OMA" id="HSQREFN"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000292">
        <property type="entry name" value="Lysosomal trafficking regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF86">
        <property type="entry name" value="LYSOSOMAL-TRAFFICKING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="3058"/>
            <end position="3164"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="3169"/>
            <end position="3473"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3668"/>
            <end position="3702"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="3807"/>
            <end position="3838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1414"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2109"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2343"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2449"/>
            <end position="2488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1214"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1236"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1414"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1444"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2117"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2365"/>
            <end position="2386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2462"/>
            <end position="2475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022110934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022110936.1"/>
        </source>
    </evidence>
    <sequence length="3873" mass="431369" checksum="1AE6FAEBAE42279B" modified="2022-01-19" version="1">MMEGGGRMGRNLRGRWEAFISLTTSEETEAAQKEKHLRLEDFLHAFLLMSANPAIDREDLVNFCGDIHSVFNILVRQFMADIQELAPTHPSDPPNHASPPCSPAAPSPLMEFLLHGRGWLVLNALCNLSSQALDFSPDFVCLLVQFIEEAMYLPVRGSHKDHRVNIPRLDACILKRNFSKKSLMSIGFANSRRSTFRGHTLSNPPSPVRFQSYQGSPLSCRRSSKDATDSSDSDSGTKTGDRKSSKRSGSDSTPRHVYSKQAPLPKAALLGEVRIVDWKLSVEDSCSNVSSVDVDAFDLCLVLLSLLERLCTSEVMHSSKRNTLALFLAPKLTHLLTIMNSHASEAKTKELSGLESQSHRWSEDLICSLQRIVLRIVVSLCMYSCTQHYEAPKLASNGILFTLLQLVKTVRQKTEKPTGVVDVQTEGSAATKTSNAGSTDNHEAQPDVNGGSPHNGPHALRPDAWSQLTLNNLHYVGEILLGVVLLLIGVMHSCCDNQIVVTHAMALLNEFATNAGYTVTESFLTFVDEKIRHLGEDAQESQKLKDCIISLLCSLAKLLIATKRAKLEYVHKFQCLKRTHNTCDYTHYTHHHHSMFGISHSAYEDERLLHPRPKSLSKVGADNSLFRARRSKCCIAVIVEMLLGLLEKVHYKGTTVRILFALEQGGVCCCLLPKLIISIFLRSLKEQPVAMRSYLLSVLSKLILEQLGGGERSEGVVQGICEECSSQDLRSLSPTVTGTKIADHYMSSDSAICSDGSQHDEDIRSVRWRVLEMYTPLLMSHDEVLSQQISGHLLHLVRHSNMVVKEELYFNVILSCFRHSNADAIDGLSNLPCFTSPPVLEHIFCALPYLLNTLSAQVEFLHEGGLTQLMQLLDMHATRLHVLRVFEVLILSEESQGAFLKNRCRSDTRDSAVSTDTLSESGETCNVVQDFVKIVCTVLPYKLPELKKAVSTPADSNESDEDWLQSCEVIEDPIERVYRSTQNRSLIEEGKVAFAESLDTIKEVESSQENGDSFEEMLLMPDQLSKLSETTLAKAADVWRINGNLLLQSASYKLQFLQQEGDILAMLLLKEALVGLAKTWKMCEGLPVTWSPSRDSVTRLRTESEYKAAPVNVFQVILDIAGSLLRICLTLQGRVEGQVIPKFLENCKGILKQSGILQSALGRPVAEMLLKVAQMQVYVHPGTHGYSITTKDYPDSTCSGEDMLHWNPEELQEAVSSDSQSEVSDMLSTEEGYEADSEREKEGIHSGDSQGEVDLDRAELTMSQHTLLHPQVCLLLLELLEGTNNNEDSDAREFPAEVACYSIKQIIAIARSSQASQNSLYHCGLPKVTLQNYRRTVSSAERVLLLELFAVLVQHNLATSELREFLQLFPTGQPFMDEDLLCTLLTIVDNTPSLPSHILSFPIVKPLSETLIGSETHSSSSTASTITDVKAGRPDQATPPSAAEAKEDKERQSASEPVQVRLGVSRSPWYIAPVQLPVRTNLPWPPTGKGFFIAAWLKVDELSMLSRLHAVPGFRRRKSVHRQASVKLTEEEIMDQELLYGKKPQRKESITRPPALQRVGLHLFSVGNRDLMMQVWVEARTCRLTIRLTHFLSGNDHVVLHEKTCSLLSLSVWQHLTLGYEEKAEGSTRTGMITVIINGQLQRDFLVEYNSPVQAKSGQSPVPYCLLGHCVQEGTDTNLPHGSWQLGNVMLFNDARVLNQEVAFHLYSMGPDCLTVSLCEGSKQGQLYSQHITQDILQSAISCEIMSGDREVELRSARESLVITYSPGNKDVYCHYEPVGNSSGPLGRVLGGSSRSYPNALLQCPATLGAALLCTLTPHSHCGLLQAIKESGGIGVFVFLFAKIVEKSSSKTVQAKALKLIMRLRSCSHALAAEFNNMMAASMIAKVLVTPKCIVGFEMLRVMLEACLTKPVLYRCSHSNEYRLHRDTQAIIQDTSLVSQLLLAWRIWEKAEAGVLPMLFRVMESLIHADHPYQAFNITQLLSIRGVQRLLMICKERHHEDLPSLTPLTCSSVVSIIKGLMGQPPDINLLAEVCDFLLAIHPAVNTFVCHAQSSFYFSHHSFVQQKAKQKLLQKMSSLDDSSDQSETSSETAKFYLPSVDLSISEMNHNRQKVAATPDRENDENAAKVKSQGPFGSPGASDWDEDRVSDMSGLCSGLLNLLSEALVVLPDSSLSKVLGIVIKPETLIVLAHHDSPLIRTRVIQLLDVFFHRASSAQIETFLKRKSFHLLANQLHQYPATRELMEACLTITVGKPVDLEQGVELMLLQEADRFQHVSSVLLMSLLENAVHDFSLCHNGICIANQLFEGVESIAHVMLVNGLVETLCNVLSAVCSRASAVGITGKPNRQRAASPKGSTRSSDSPEDITGREKTKTTLEDSSRTDEGTPSKDANIGCEGSPNGSETLNPEVDGGVGLRTLGNETGAGIAQPAKVNGFMGSNLEEPDLITLPREESTPSLGGSDVDSGDVDTDGWDGGDDASSVSKDPLPRLPDRLSETVQILIKDIHHFMACIANHVFSSVSQFDYFENMMLLLGGMEEKLRKRHGPSSVIPDIVYDTQCYIVKEVLDHFRATSMSVDSAVTKGKKAMTLQRSVSYSERKYEEYKWKRRNSSDSEAKGSRGRFASTSSITTEFGMSLISESNLDDTMSLSSEQEQLSDFCLQAEDRRYSSQLDTILRMQRVHASSTSSRVPSRKKTPELAGEQLLAKRFQRICLLTVNLVVQRDPSCVNLVKSTALGSPEDGFIQAVDPTFIQLAKQLFHFLTDALAATMERKLGQRKQWESILWSSRDTLRLQLHRLLVHMMAPWQSTPIRVYMLQIACIPRANHILQTVLNSNLQQHLGKFELFLFDLLRNHSQLTEANLVLCQQLMDLLEICGFHPLYEEDMDVTTQDRVKIELEKMITEEQSSQEAHIKQRLDGAVSAWSKLDPFAKEVANSAMEVTQLVTAYQNGQRIRFLEFLRSTIASSLDVRSAWQDLIQSLTHERAVWYDPQTYPSSWQLDPTEGPGRVRRRLQRCHLGIPNKFLLPQWQERHPPQSTKPLDYLFEDSVQSSNSSEFKRRLQKNEKISNAFFCKLVTPASVNTGDLLQGVNSMYFVSEEMPDSSHAQVNPFDRDMMTISWLYVDIKELHLRWYQLRDNALEIFLVNGQTLLLAFENTRERDTLYQQIKSCDLPNLVEVDDISDVTQAWRLGQMTNYEYLTQLNKLAGRSFNDLMQYPVFPFVLSDYTSRILDLENPNSYRDLTKPVAVQSQAMENRYKENYKFLKEEYQKLKGLRMGQTMFWTKPYHYGSHYSNSGTVLQYLVRLPPFTKMFLHYQDNHFDLPDRTFHCVDTSWRLSSYQSSTDVKELIPEFFFLPEFLVNNEGYNFGIRQSGAHVDDVILPPWANGSARLFVLIHRQALESVYASKFLHAWVDLVFGVKQQGSLAVDSINVFHPATYFGIDTTAIKDPVKQRAVETMIKTYGQTPKQLFVNYHPSRVEHDSFVPDNFAIGSVGILAGLSQRPPTKANTGPEASNILAPVNTVKGMRWGNYLGSASGPDPVIRYKKHFPVPLTTLIPLPTGDVCGVAQHLCLLLMYSKERGVSSMNAVDIKWSGIVSWGHPDAILRVQIRRKSLPLNLLHATPTDKITCCSSVSDCRLLFIGAMSGIITAYPTRYNPDKQCNIEVVGAAVQLFGHTACINSLCVSRAYSIMVSSSQDGTCIIWDLNRLCYIRALCDGDVYRDANGVTAVTVSDVSGDIAISTGMADGGSSVSLWTINTSLVSRRLCDSEVHCLAFSNAPEGIAVNSLVAGCEDGVIRFWSTIDLTPIRVLVGNTHSPIISLAFTNDSQYLVASNQDGLVVTWGNKEGSRRAPKMEAFLDIGKIRNPGNNKISSLGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHD4</accession>
    <name>A0A8B7XHD4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho GTPase-activating protein 8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079350.1">
        <property type="nucleotide sequence ID" value="XM_022223658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHD4"/>
    <dbReference type="GeneID" id="110973119"/>
    <dbReference type="KEGG" id="aplc:110973119"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001136">
        <property type="term" value="P:negative regulation of endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="106"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="295"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079350.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60003" checksum="70CD985E8D1B53E5" modified="2022-01-19" version="1">MAEAAQNNVNRENLTIDLDVPAEARGTPEGQEGTFGDVDVDFEEDEELSLAQDDAEMVANAQLKLCSPSDESMPGGGEESQATSSAEATPSAENTETIDVVQAEDTFEDIAKHNIIQVAGDDNVGRKLVLFYCCRLPPTKTYNTSRLLGFLKYTLDQYVESDYTLVVFQYGLVHANRPNFNWLTQAYQSLDRKFKKNLKALLIVHPSNLVKVFWGIFRHLVSSKFSRKVNYIHLLSELKGLTDLERLAIPQTVLEHDKRVIERRKGKGQRSAVDQDTTAIDASNKAPPKTQQFGVSLDFLAENEGGDPIPKVIRQTVATIQKRGLETEGIFRRCPNANTIKEVQRMYNEGKEVDYNALLDVHVPALILKTFFRELPEPIMTFELYDEIMNMHDLQDNDARIAACRSIICEKLPERNYIILQHLMDLLHKISENSDKTKMSAANISIVFSPNLVWPRSKAMSLVSLAQINSFVATLLYHYDAIFTREVAEQRRVPPTRDHDDTGGVTQETTPETHSEGQPKANGSEVANGNDAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIR6</accession>
    <name>A0A8B7XIR6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17">Corticotropin-releasing factor receptor 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC110973366</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079829.1">
        <property type="nucleotide sequence ID" value="XM_022224137.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079830.1">
        <property type="nucleotide sequence ID" value="XM_022224138.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="7tmB1_hormone_R"/>
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        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
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    </dbReference>
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    <dbReference type="Pfam" id="PF00002">
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        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="8" id="KW-0675">Receptor</keyword>
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    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665437" evidence="12">
        <location>
            <begin position="33"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="192"/>
            <end position="215"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="295"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="423"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="13">
        <location>
            <begin position="100"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="190"/>
            <end position="457"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004651"/>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023170"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="ARBA" id="ARBA00023224"/>
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            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
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            <dbReference type="PROSITE" id="PS50227"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50261"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
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            <dbReference type="RefSeq" id="XP_022079829.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022079830.1"/>
        </source>
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    <sequence length="529" mass="59211" checksum="0A7B6EFB32BEBCF8" modified="2022-01-19" version="1">MARQAGRSILGMTTTLRLPLLLTWLTFRQCQAVPLPPRNDAATTPSVATTEYTEFATIYGTEEVSPGSENVTGPSDSLVGGLGSFDGLFDMANFSFENYFCDLTYRERTSELRQTGALFCNASHDKVMCWPPTPGGQNASLSCPVFNSSALRAYRACENTGNWAKWTDYTECLKTYTAPTIPGEPTHQSVSYIWLCGCILSLIFLVIMLFIFCYFKSLQCTRINIHKNLAVSFILKYICMIIQLSPTLSSQNPADEYYEGGDVAPIAKANDTSEHVLVFCRLLTVLLEYFTMANIFWMFVEGLFLTTRIAVAVFSNESNFKLYLLIGWGSPLLFINVWVVLMAIYDPNPCWEDYHAVPYIWLIRVPMIAAILVNSLFLINIIRILVTKLRASNTVETAQMRKSMKAVVVLFPLLGLTYLIFIWDDGGAVSGSIYHVVNAVLQSGQGVFVAVIYCFMNAEVRMAIQRRIAKSRYKFGSASRRRTHTNGSCVMATSSEVVLAVTFRKNVQGSTSIDQLSQEMKPFTECVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLA3</accession>
    <name>A0A8B7XLA3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Beta-2 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110973977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
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            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_022225250.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
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    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="64"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="291"/>
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            <begin position="22"/>
            <end position="289"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022080942.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35025" checksum="E54FD6D53346B324" modified="2022-01-19" version="1">MAEPLSVLHIIKTIIGVIGLIGNGVVATVICKVKFMHTLTNAFICNQAVVDFLGSLFLIVTSTIPVPDPSPHTSACKLWLPDVLLWACFTSSTFNLLSVSCERYVAIVVPFKYATLYTKKSVTCMIVAIWLLGPIFEAPYEAALTTYKDGFCLLSSEIAWFCVVFFLVKLFVPAILMIFFYSHMAVKLKRSANRIAVIAPTVSGQVESAPGDRMGESHRENAEQSLLRARRNIFKTLLLVLITFLVCWTPNQLFILMVNLGCSMDSTGTIYIISVSLVAINSCANPFIYAFKYRRFRRGFLSLIGRKIQTEGDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLL1</accession>
    <name>A0A8B7XLL1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Iodothyronine deiodinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iodothyronine deiodinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081703.1">
        <property type="nucleotide sequence ID" value="XM_022226011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLL1"/>
    <dbReference type="GeneID" id="110974403"/>
    <dbReference type="KEGG" id="aplc:110974403"/>
    <dbReference type="OMA" id="MASSASX"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004800">
        <property type="term" value="F:thyroxine 5'-deiodinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042403">
        <property type="term" value="P:thyroid hormone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000643">
        <property type="entry name" value="Iodothyronine_deiodinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781">
        <property type="entry name" value="IODOTHYRONINE DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11781:SF22">
        <property type="entry name" value="TYPE I IODOTHYRONINE DEIODINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00837">
        <property type="entry name" value="T4_deiodinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="1" id="KW-0893">Thyroid hormones biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081703.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27747" checksum="D6BE7FC22E26AFAC" modified="2022-01-19" version="1">MQNAIDDELLSDRAMVQRVLRKQREVLEGERGKQAFAEINDPTQPNLLRRIKRAQHKADRIALEELGLDKHVKDWSKFTGLLMPIMAKYKSDQEACVLGGTLAQLFHEYKDRADFLCIYLAEAHPAEYFNLNTTFKVPQHQTKEDRVAAAYKLLEEDREHHHTFTDDPLDCSLIRIVTDTMTNDFAQVYNAHPDRVFIFQGDIVIYVGDTIGKQMMNPDVLMTEATRNWLENYFKDTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLM3</accession>
    <name>A0A8B7XLM3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 243-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081057.1">
        <property type="nucleotide sequence ID" value="XM_022225365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLM3"/>
    <dbReference type="GeneID" id="110974047"/>
    <dbReference type="KEGG" id="aplc:110974047"/>
    <dbReference type="OMA" id="HAMLIHW"/>
    <dbReference type="OrthoDB" id="17800at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022564">
        <property type="entry name" value="DUF2678"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28603">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28603:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10856">
        <property type="entry name" value="DUF2678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081057.1"/>
        </source>
    </evidence>
    <sequence length="121" mass="13499" checksum="55D05AC7E3FC97A9" modified="2022-01-19" version="1">MSYYESDTVQTPLFGERQTRDRVINLSLGIITAILVTVTLVSAFIFPAWPPSAVNITFAFVIVLVCGGNLLLIYWYREGDIAPKFRGLIYYNAATVLFLCVCANLYIHNVEKAPKTPATAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLR7</accession>
    <name>A0A8B7XLR7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 2J6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110974046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081056.1">
        <property type="nucleotide sequence ID" value="XM_022225364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLR7"/>
    <dbReference type="GeneID" id="110974046"/>
    <dbReference type="KEGG" id="aplc:110974046"/>
    <dbReference type="OMA" id="IRIMMET"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF417">
        <property type="entry name" value="CYTOCHROME P450 508B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022081056.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="58309" checksum="D792476F0E400CC2" modified="2022-01-19" version="1">MGVFQRVMNFLDVRTVLLGLFCLLVLRRWLGRPKNLPPGPWGFPVLGSFPAIAWAMCRGLEPHHLFKKYAEKYGPVFCLNIFNKRVVVLNDYALVKEAFQHPQLSDRPKNLITEVSKTEEVLFSSGEVWMELRRFCLTVLRSFGVGRTSFEEKIGIEAEELIKEMAAFKGGPFNPKPLLGNAVANVICSVIFGKRYAYTDREFAHLLDLLSRNIKLAGDGGMTLIFPSMRHLPFLPTSELISNLKAIRAFIKNVIDSHRKTFDADNLKDLTDVYLMEIEQIQAKNKGGGEFDGENPQTSRYSHLGERNIVGTISNLFAAGSETTATTLQWCILYMMLHPDVQSRVQAEIDDVVGRNRLPRMADVPKLNLTRAVIWEVQRLANIVPLGVPHCAALDTTIRGFLIPKGSFLMSNLWMIFQDGRVWPEPRQFKPERFLNEKGEAVRTEKLIPFSIGRRSCIGEHLAKMELFLFFSFFMHQFTFKKPDNSPPLSLSLKGRGGITRSPLPFDTCAILRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLU1</accession>
    <name>A0A8B7XLU1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080935.1">
        <property type="nucleotide sequence ID" value="XM_022225243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLU1"/>
    <dbReference type="GeneID" id="110973970"/>
    <dbReference type="KEGG" id="aplc:110973970"/>
    <dbReference type="OMA" id="WDVDILL"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF86">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080935.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="31519" checksum="D4C8E375178E900D" modified="2022-01-19" version="1">MAPKTVLITGCSTGMGLAAAVMMAKDARFKVYATMRNLKSKTDLEKAAGRTLNKSLFIRELDVTKESTIKSVVGEILKENGRIDVLVNNAGYSETDAIDQLPLEACQAMMDTNFWGAVRTMRAVLPAMKRQKSGRIINVTSATALWGTPFVATYTAAKFALEGFTESSAPVLKRTYNIRMSIVEPGPTQTAMVTKFGAVSPAEQSKNFDPPLRDEYVKFMEAFAAPMMKSMVSADEAAKVIVEAIVSENPHLRYQIQDLYKKLAAKKFVDPHTDAILSVEKFLDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM04</accession>
    <name>A0A8B7XM04_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Activating signal cointegrator 1 complex subunit 3</fullName>
            <ecNumber evidence="16">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">LOC110974482</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="16"/>
    <dbReference type="RefSeq" id="XP_022081843.1">
        <property type="nucleotide sequence ID" value="XM_022226151.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081845.1">
        <property type="nucleotide sequence ID" value="XM_022226153.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974482"/>
    <dbReference type="KEGG" id="aplc:110974482"/>
    <dbReference type="OMA" id="MCSATEF"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000028">
        <property type="entry name" value="activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000113">
        <property type="entry name" value="activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058856">
        <property type="entry name" value="ASCC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26582">
        <property type="entry name" value="ASCC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="481"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="729"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="1332"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="1540"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022081843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022081845.1"/>
        </source>
    </evidence>
    <sequence length="2195" mass="248194" checksum="4FC8D080372B5196" modified="2022-01-19" version="1">MSLPRLTGSIRAFSDVTAEVTDSSSLGNVSLQKKQSLRSERQARQGLTWTKLSHEIQTHCGHHKAEVSSKLHELIHVTREMVGSDAPMALVESTAVLLFTKLKDGEELTHRRTAELHAAIGPFPSTTGVRAHKAICSLVGLLPLGAGEDLDRLMAGEESEMEEFGQKISFSFTPRNLDVGDDSSESEEETEEPILKFGYSAAVAARPSGKHQETNANKKSMNLGWLRKQIEDQFGRGGTPLGMSIDSLVAKLLGDLTSGKSNDELQNELFDLLGFDCFELIERLLTNRSQLVQAASRNQMSQIIAEGKKERQARNVYGSQVIIQSEQEKELNKQLRKEEKRLARQEARGNSAPGEGISNEPFFDPQYLRMQRERALMNASVAPILTKRTSGAPKAAYPNVYDALAEAQKTSAFAGAAKVMLPEGFERKNIKMYEEVTIPPSQAAPTSVGQHRVAISDLDEIGQTAFRETHRLNRIQSVVFDTAYHSNDNLLICAPTGAGKTNIAMLTILHELKQHLDQGVIKKDEFKIIYVAPMKALAAEMVRNFGGRLAPLGIAVKELTGDMQLTKSEIAKTQMLVSTPEKWDVVTRKSTGDIALTQLVKLLIIDEVHLLHEDRGAVIESLVARTLRQVESSQSMIRIVGLSATLPNYIDVSRFLNVNPYVGLFFFDGRFRPVPLGQTFIGIKATNVFQQRQDMDYVCYEKARAMIIEGHQVMVFVHARNATVTTAQSLRDIAKAQGDSLMFRPDQTSAFGSAEKQVSKSRNKQLRELFPDGFSIHHAGMLRQDRTLVERCFREGHIRVLVCTATLAWGVNLPAHAVIIKGTQLYDANKGAFRDLGILDVMQIFGRAGRPQYDDHGEGIIITSHDKLTHYLSLMTRQNPIESQFIESLEDNLNAEIALGTVSNVEEAVRWLSYTYLYVRMHLNPLAYGINYKSKENDPSLEIYRKELIVKAGRALDKAQMIRFDQAAGDFHSTDLGRIASHFYIKYATIETFNQHLKPLMTESGVFSMVSQAQEFQQIKVREDEIKELESHHSDGSCCMPAVGGVENAHGKVNILLQTYISRGFVDSFSLVSDLAYVAQNSARIIRALFEITLRKGWPLMASQLLTLSKMVDRRLWSFESPLRQFPQLSQEVQRKLENRKLTIDKLREMRASEIGHLIHHVAMGDKVKQCVNQLPCIELEATIQPITRTILRVRLTITPAFRWSDRVHGTASESWWIWVEDPDNNHIYHSEYFLLHKKQVLSREPQGLVFTIPIFEPLPSQYYIKAMSDRWLGSETIFPISFQHLILPERHPPHTSLLDLIPLPITALGRPEYETLYSFTHFNPIQTQIFHTLYHTNQNVLLGAPTGSGKTIAAEIAMFRVFNEQPGMKVVYIAPLKALVRERIDDWKVRLQQKLGKNVIELTGDVMPDIKAIGGADVIVTTPEKWDGVSRSWQTRKYVKAVSLLVIDEIHLLGDERGPVLEVIVSRTNFISSHTEKPLRVIGLSTALANARDLADWLGIKQNGLFNFRPSVRPVPLEVHIQGFPGKHYCPRMATMNKPTFQAIRTHSPTKPTLIFVSSRRQTRLTALDLIAFLAAEDNPKQWLHIEEAEIENIISGIKDTNLKLCLAFGIGMHHAGLHERDRRTVEELFVNQKIQVLIATSTLAWGVNFPAHLVVIKGTEFFDGKTKRYVDFPITDVLQMMGRAGRPQFDDQGTAVIFVQDIKKHFYKKFLYEPFPVESNLLDVLAEHLNAEIVAGTISSKQDAMDYITWTYFFRRLVMNPSYYKLEETDHTSINKYLSFLVERSLLELENCYCLAIGEDNRSIEPLTLGRICSFYYLHHQSVRMFRDTLGPDTSLIDLITILSDAHEYEMLPVRHNEDGINSDLAKKLPLEVNPHSFDSPHTKTHLLLQAHYERQPLPSSDYATDLKSVLDQSIRIMQAMIDVSADQGWLATALRIMNLVQMTLQGRWLHDSALLTLPHVEHNILHCFKPPSKGKRSAPIQSLPELLAVCRGNRSILQKMLTPEVSDGHLEDIWNVLQRLPVIEPKLSVRGWWADGGEEEDRLLPTTYITGVPKDSDYLPVHADQEYVLQVDLRRLYRQRQHDTKCHAPRFPKSKHEGWFIVLGDLESKELLALKRIGYVSSRNVVQLAFYTPETVGRVIYALYIMSDCYLGMDQQYSVCLDVQEADITAQFNTEVMLEDGELDELVEHYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XND5</accession>
    <name>A0A8B7XND5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC110974776 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110974776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082333.1">
        <property type="nucleotide sequence ID" value="XM_022226641.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974776"/>
    <dbReference type="KEGG" id="aplc:110974776"/>
    <dbReference type="OMA" id="DAQDQND"/>
    <dbReference type="OrthoDB" id="10043087at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="37"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="37"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034229220" evidence="8">
        <location>
            <begin position="22"/>
            <end position="3948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="3905"/>
            <end position="3930"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="9">
        <location>
            <begin position="48"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="189"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="270"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="351"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="437"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="522"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="607"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="691"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="776"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="860"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="945"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1029"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1114"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1198"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1283"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1367"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1452"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1536"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1621"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1705"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1790"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1874"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="1959"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="2044"/>
            <end position="2127"/>
        </location>
    </feature>
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        <location>
            <begin position="2129"/>
            <end position="2211"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="2212"/>
            <end position="2296"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="2297"/>
            <end position="2380"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2380"/>
            <end position="2417"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2419"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2460"/>
            <end position="2499"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2547"/>
            <end position="2586"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2589"/>
            <end position="2628"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2634"/>
            <end position="2671"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2679"/>
            <end position="2724"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2732"/>
            <end position="2777"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="2780"/>
            <end position="2816"/>
        </location>
    </feature>
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        <location>
            <begin position="2820"/>
            <end position="2902"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="2905"/>
            <end position="2988"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="2992"/>
            <end position="3075"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="3079"/>
            <end position="3162"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="3166"/>
            <end position="3250"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="3255"/>
            <end position="3335"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="3337"/>
            <end position="3420"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="3424"/>
            <end position="3507"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="3511"/>
            <end position="3595"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="3600"/>
            <end position="3680"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="11">
        <location>
            <begin position="3682"/>
            <end position="3765"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3807"/>
            <end position="3841"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="3844"/>
            <end position="3881"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2407"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2448"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2489"/>
            <end position="2498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2576"/>
            <end position="2585"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2618"/>
            <end position="2627"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2661"/>
            <end position="2670"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2714"/>
            <end position="2723"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2767"/>
            <end position="2776"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="2806"/>
            <end position="2815"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3831"/>
            <end position="3840"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="3871"/>
            <end position="3880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022082333.1"/>
        </source>
    </evidence>
    <sequence length="3948" mass="415501" checksum="BBEBC5E8B5D78D2E" modified="2022-01-19" version="1">MERTLVILVISMVLLAYETFAQECAVNMCTNGENCYTRNSAEGYVCECNLPFRDSYNCAIGPDNQEIFTCYGPSCTAGVFESLNYPSPYPNRYRALYLLYIPGASGISFTFDDVFGIETDKDELYVGKGLTVDFTALNGVNTVGPDVRFFEGFARPADFTLENTDTAWMYFITDKNLEYSGFSIRYQMVDDMAPVIENCPNSLIVSSTNTVGGQVFWTPPTATDISQITTLSTHNPGDVFPIGTTTVTYTFTDTFGNSNQCSFDVTVQFVDNVPPVISNCPASFTVTTTSTAGGQAFWTAPTATDVSQVTTSSTHNPGATFPVGTTTVTYTFTDTAGNSDQCSFDVTVQFVDTIPPTITNCPQSFTRTAPFGSTTIPVTWNEPTATDNLGTPTLVIREPVSGSPFAVGQTTTVLYRWTDSAGLSSDCTFDVTVIPLGDTTPPVVTFCPDDITRFVPFQSTGTTVTWTEPTATDNSGSVTTTQTHTSGSFFATGSSQTVTYTFRDAEGNEAQCQFNVRIFQQSDTVPPVVSICPENIALTVPFQSTGTTVSWNEPTVSDNSGTFTTTQTHNSGDFFNVNTQTTVTYTFTDAAGNQAFCTFTVTVTGLGDNTPPVITSCPSDITMFVPFQSTGTTVTWTEPVVSDDSGSFDTVQTRTSGSFFTVGDNTVTYTFRDAAGNEVSCSFVVRIIELGDTEAPVVADCPPNEAITVPFQSTGTTVTWTEPTVNDNSGTFTTTQTHNSGDFFNANTQTTVTYTFTDAAGNQAFCTFTVTVIEQGDTAPPVVTSCPSDITQFVPFLSTGTSVTWTEPTVLDNSGAFDTVQTRTSGSFFPVGETTVTYTFRDASNNEAICSFVVRVIELGDTEAPVVSVCPENIALTVPFQSTGTTVSWNEPTVNDNSGTFTTTQTHNSGDFFNVNTQTPVTYTFTDAANNQAFCTFTVTVTGLGDTVDPVITSCPSDITMFVPFLTSGTTVTWTEPVVSDNSGSFDTIQSRTSGSFFAVGDNTVTYTFRDAAGNEASCSFVVRVIQLGDTEAPVVSVCPENIALTVPFQSTGTTVSWNEPTVSDNSGTFTTTQTHNSGDFFNANTQTPVTYTFTDAAGNQALCTFTVTVTGLGDTVPPVVTSCPDDITQFVPFLSTGTTVTWTEPTVLDNSGAFDTVQTRTSGSFFSVGETTVAYTFRDAANNEAVCSFVVRVIELGDTEAPVVSDCPDNIALSVPFLSTGTTVSWNEPTVNDNSGTFTTTQTHNSGDFFNANTQTTVTYTFTDAAGNQAFCIFTVTVTSLGDAVPPVITSCPSDITMFVPFLTSGTTVTWTEPVVSDNSGSFDTIQSRTSGSFFAVGDNTVTYTFRDAAGNENSCSFVVRIIQLGDTEAPVVAVCPPNEAITVPFQSTGTTVTWLEPTVTDNSGTFTTTQTHNSGDFFDANTQMTVTYTFTDAAGNQAFCTFTVTVIEQGDTVAPVVTSCPDDITQFVPFLSTGTSVTWTEPTVLDNSGAFDTVQTRTSGSFFPVGETTVMYTFRDAANNEAVCSFVVRVIELGDTEAPVVSVCPENIALTVPFQSTGTTVSWNEPTVNDNSGTFTTTQTHNSGDFFNVNTQTTVTYTFTDAAGNQAFCIFTVTVTELGDTVDPVITSCPADITMFVPFQSTGTTVTWTEPVVSDNSGSFDTIQSRTSGSFFAIGDNTVTYTFRDAAGNEASCSFVVRIIELGDTESPMTVVCPESMSITVPFQSTGTTVSWNEPTVTDNSGDFTTTQTHNSGDFFNANTQTQVTYTFTDAAGNQAFCIFTVTVIEQGDTVPPVVTSCPSDITQFVPFLSIGTTVTWTEPTVVDNSGAFDTIQTHTSGSFFPVGESTVTYTFRDAASNEAVCSFVVRVIEQGDTTPPDVTSCPDSTAVNVPFQSPGTAITWNEPVATDNSGSFTTTQTHDSGDFFNANTQTTVTYTFTDAAGNQAFCIFTVTVTELGDVTPPVVTSCPADITEFVPFLSSGTIINWNEPVVSDNSGNVATTQNRASGSFFTTGSDITVTYTFRDAAGNEAVCSFRVRVIELGDATPPEVTNCPADITINVPFQTAGATASWAEPIVTDNSGDFTTTQTHNSGDFFNANTQTPVTYTFTDAAGNQAFCTFMVTVTELGDAIPPVVTCPANINEIVQFGAGGAVITWLAPTVTDNSGSFSLVENTNNPGDFLLTGQTIVTYRYRDPAGNENSCSFTVTIMEVDTIPPVIQTCPSNIVDQVEFGVSGKSIVWTEPTGIDNTGGQVIIAQRNFQPGDVFPVGETVVTYVLVDPSGNQATCQFTITIIMVDTIRPTIVNCPAGITQTILTGTAPIAVQFTEPTATDNTGVVNLAFNSHSSGDLFPAGQTDVTFIFEDEAGNQATCMFTVTINEANPCLSQPCLNGGACISESLTAYRCLCTECFTGNRCELPRDACDGNTCQNGAACAALPGSCTQYECQCPGCFIGQFCERRVDSCENNQCANGAVCVSSSQNCIEYTCQCPPCYAGQFCDIPISACANHGCQNGGVCAPVVSPNNVYACSEYTCACTGCFTGERCEVQRDACNPNPCLNGAECSVLPDNCYSYTCQCNGCFSGFNCEIPISSPCDDNPCQNGGVCSVIQGTCASYACSCPNTHIGVNCEIAVTVNPNPCNSFPCLNGASCLTMDANHYVCLCSPNDVGQNCQSTIVSVPAMDLCDTSPCQNGATCFNSYNSNTGTNLIPQYTCQCTNGFTGPNCASPVVDNPSLNVCSLEDTPDCEQGATCSNAFHSFDNNVDYICNCPVGFIGHNCETISANPCNSNPCKNGAQCTAFNTYFVCTCPAGYAGSTCEIPVGDNIDPVIDGCPDSVNRIVGTGSSSVVTWTAPTATDNSGSAFLVYSSHASGSSFPVGTTAVTYVFSDPSSNYAICTFFITISTTVVDNTPPVISNCPSNRAVTAAVGATSAAVSWVEPTATDNSGATVNRVSTASPGDTFNLGSTTVTYTFTDISGNDAVCSFVVTVNPGTVTDNTPPVISNCPNNQAVTAAVGATSAVVTWVEPTATDNSGIAVTRLSNASPGDSFNLGSTTVTYTFTDNSGNEAVCSFVVTVNSGTVTDTTPPVISNCPMGPSATLSQGATSVAVTWTVPTATDNSGGTVTRTSTHNSGDLFSAGNTQVTYTFTDPSGNEARCQFVVMVSSFSGGDTQAPVISGCPVSQTVAPDAGSNVATVSWVEPTAVDNSGQEPGVAKSHQPPATFTSNTVTRVTYIFYDNFGNFDTCDFTITVTASSPGTDNIPPIISDCPNGITVTGTNNAVVSWVEPTATDNDGQPVSVVKSHEPNSIFNVGSTTVTYTFSDTSGNVAICSFVVTVTPATDNTPPVISNCPSNQAVTAAVGANSAVVTWVEPTATDNSGIAVTRSSDASPGDSFDLGSTTVTYTFTDNSGNENICSFIVTVNPGSVVDNTPPLISNCPTGASATLPQGATSVAVTWTVPTATDNSGGTVSRTSTHDSGDSFGLGNTQVTYTFTDPSGNEARCQFVVMVSSPTASDTTAPVISGCPASQTTAPDAGSNTATVSWIEPTATDNSGVEPGVSRSHTPPATFSANTVTRVVYTFFDNSGNFDTCEFTVTVTEGTSTGDNTPPVISNCPNGVTATGTNNAVVSWVEPTATDDDGQPVSVTRSHVPNSVFNAGSTTITYRFTDTSGNEAVCSFVVTVAAPADNTPPVITNCPGNQAATAAVGATSAAVTWVEPTATDNSGTAVTRLSNASPGDSFNVGSTTVTYTFTDNSGNEAVCSFVVVVSAAMTNTNPCNSNPCPADQNCYYRENEYLCLADGRRRRDVDQIKTDGCMCKNGGVCMGDKDNGHMCACPTGYEGILCEQALVDVCQPNPCANNGTCIEYTTTTYVCICSPGWAGRRCEQAQRKPDPDHSMAARSEWSSTVQLMVGCSLAVLGTVVIVLAATVCRLAPRRFNGAQKFRIDEATLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNG4</accession>
    <name>A0A8B7XNG4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation channel sperm-associated protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022081596.1">
        <property type="nucleotide sequence ID" value="XM_022225904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNG4"/>
    <dbReference type="GeneID" id="110974332"/>
    <dbReference type="KEGG" id="aplc:110974332"/>
    <dbReference type="CTD" id="117144"/>
    <dbReference type="OMA" id="WFFSAMD"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060296">
        <property type="term" value="P:regulation of cilium beat frequency involved in ciliary motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028746">
        <property type="entry name" value="CatSper1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47193">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47193:SF1">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="7">
        <location>
            <begin position="171"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022081596.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="57014" checksum="782F2D5257FE32F6" modified="2022-01-19" version="1">MKTAMNSGNAEIKVDTTTSISPQEASVMFVKENGHRQAESTADRRGDMDDLLDPSMGPTNLSFIKYHMRRHRRQVKIAQLPMPSDSLKKTASAAAAAASALGSVSEILDKGTEDAGDVHRKSFESAHAFEAANINDQETLDLLAQEQRRQKVLRSAGTFRRHMYDLTESLAFNGFILGVILLNTGIMCALTYDTVAVRAGWHATVLDHVFLVIYFMECVLKLYVWRLDYFKEQWNIVDFTIVVVNIADFSVSTLVGNDVNILNFIGIFRAMRALRALRVLRTVRFLKSLQVIMNTCLQSVQSMGAITMLISLFLYMFAVIGRGLYAEVDPKRFGNLGSAMFTLFQLLTLDDWFYIYAEAVAKDPGYFHIIFYLVLYIAFEYFIFLNLFVAVLVDNFQLTLEAAAAKEAIRKEAIKVEEEDTDEDTHDLLPKSRVSSISSEELFRTKRTIEDFYSSDAYSDRDRIYLAHCFRLLAAIDYNGNLSRNQKGTLDKIVDTVQETTDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQF1</accession>
    <name>A0A8B7XQF1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BANP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17 18 19 20" type="primary">LOC110974729</name>
    </gene>
    <organism evidence="14 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BANP/SMAR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082231.1">
        <property type="nucleotide sequence ID" value="XM_022226539.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082232.1">
        <property type="nucleotide sequence ID" value="XM_022226540.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082233.1">
        <property type="nucleotide sequence ID" value="XM_022226541.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082234.1">
        <property type="nucleotide sequence ID" value="XM_022226542.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082235.1">
        <property type="nucleotide sequence ID" value="XM_022226543.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082237.1">
        <property type="nucleotide sequence ID" value="XM_022226545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQF1"/>
    <dbReference type="GeneID" id="110974729"/>
    <dbReference type="KEGG" id="aplc:110974729"/>
    <dbReference type="CTD" id="54971"/>
    <dbReference type="OrthoDB" id="10052653at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034504">
        <property type="term" value="P:protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2590">
        <property type="entry name" value="BEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042343">
        <property type="entry name" value="BANP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16243">
        <property type="entry name" value="BTG3-ASSOCIATED NUCLEAR PROTEIN BANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16243:SF2">
        <property type="entry name" value="PROTEIN BANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10523">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01025">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BEN" evidence="13">
        <location>
            <begin position="183"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="405"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022082231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022082232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022082233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022082234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022082235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022082237.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49355" checksum="E2B328ED7207D4B7" modified="2022-01-19" version="1">MSSVKAEEETSDEAMLHMDVEQIPMVPTMLAQDNLEDEGPVAKRQRLDDGDARTSMDDSIKAILFNINKAICCRLDSMEQKLTNLHNTCMKMGRKVDCLNLTVSRAMAKIKDVETAISESNGTPSPNNAVVIGIPSEEEQREPSSPQASSLSRNLSRNVTLITLNTEEDFPHGSWLGDETNVECRVRCGILPTDMLHVMQTSKTPEKCALKLLDYLFDRETQATSNLSGTGKHGKKQLNPLMIYGLRCHLIKHFGITDTDWHRIRMNIDSKCRTAFRRKQRGLPLTVKAFGYKTSTPESDHMFAERFEERQDTMNDSHSSDDCSSLHTHRVHVQLPVDHTHLQELSHDEEHHAQAGSVLKKVQIQQDGIELHEGQINITQTGEIQIAVVEDHGTAGTTLVLQQSEPVPDNHHHHPDDEEGIHEVRGQDGVMDSSSVKSGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR31</accession>
    <name>A0A8B7XR31_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">alkaline phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110974854</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022082455.1">
        <property type="nucleotide sequence ID" value="XM_022226763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR31"/>
    <dbReference type="GeneID" id="110974854"/>
    <dbReference type="KEGG" id="aplc:110974854"/>
    <dbReference type="OMA" id="AHIDTGH"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596:SF5">
        <property type="entry name" value="ALKALINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034219977" description="alkaline phosphatase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022082455.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="55833" checksum="075ACF6716FEE022" modified="2022-01-19" version="1">MASKAVFVLVCLVATCKLTIVLGADSGTCDVNINKPRTPAFEKNLKDVAVEAAKPDYWRKQARETMKNAIKLGENLNKNTAKSIVLFIGDGMSIPTAVGARILKGQKNDMPGEEGFLSFEKFPYVGMSKTYNVDMQVPDCASTATAILTGVKTKSRVVRSERRCGARGLLLGSRCSWSTGIVTTDAIVGNTPAAAYAHSPNAEWKLESPTGCAVDDIAKQFVGDGVEIDVALGGGRYYFMMDDQPDPADSGVTGGRRDADLIEAWKTKYGKLGSMAYVTDKAALQSLSTSTDYVLGLFSRLDMSYNEGRSVKEPSLSEMVEKALQLLQNKNQNYLLLVEGAHIDTGHRQNKVGRALHETLAMDKAVEKVVSMTSDLDTMVIVTADHGHTMTMAGYPCRGQNVLGKVYAKEEFAQLSDGRSYTTFGYANGPSAVEVQKSFVEKGGRPIIDDIDTEDLDYQAQSLVPLAEETNGGEDVQIFASGPHAHLAQGVHEQSYINTLMTYGACLGRYKTRTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRT8</accession>
    <name>A0A8B7XRT8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110975084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082907.1">
        <property type="nucleotide sequence ID" value="XM_022227215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRT8"/>
    <dbReference type="GeneID" id="110975084"/>
    <dbReference type="KEGG" id="aplc:110975084"/>
    <dbReference type="OMA" id="LWTYFVC"/>
    <dbReference type="OrthoDB" id="438211at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022082907.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="29171" checksum="4D3A6A87C7018875" modified="2022-01-19" version="1">MATTPCGTCSKIMLFIVNFAFWLSGIAVLGMGIWVSIDRNTMEFLKVFDYPIFRNLGFAMIAVGGFVTMLGFIGCFGACHESKCLLWTYFVCLLLLFLSEIVCVALAFSYTEQVKDYVKVKLGEPVMHGYSKKKTSIVKAVDSMQETLMCCGNHNHTDWQGSQWYKEVVSDKRQNETVPSSCCITTEIYERYKQCQNKDMDPNKYRHSQGCFQALYTKFLMYIWFIGGVGIGIAVLQVLIMVITIFLLRNLTDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XU34</accession>
    <name>A0A8B7XU34_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Germinal-center associated nuclear protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083515.1">
        <property type="nucleotide sequence ID" value="XM_022227823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XU34"/>
    <dbReference type="GeneID" id="110975373"/>
    <dbReference type="KEGG" id="aplc:110975373"/>
    <dbReference type="OMA" id="DLMEKCA"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="468"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083515.1"/>
        </source>
    </evidence>
    <sequence length="851" mass="94142" checksum="DB8254F46FC0F240" modified="2022-01-19" version="1">MSSRSYYNQKKKKEALRRLSQSGARGVKSPRDAVPDDPLRQERGTRRHQRRSMEEDDHHSAGGIFGGRRVIATDSPLSGTHLVIQANVGGQSSGADTPDTEPDQPRRVVTSQPTSVPQGPFKLFGKSAGVSSSPPSDKTLPGGGVSSGIFNSPQKSAEESEAPGSEKQYQASPTRRSVFQAETSNFFPIRPLSGNASADDLQTSHKGTNSAGSLSAQDSTANPFAKRPQEVSLHSSATEVPESLFRSKEASPGVDSVTRNLFGKPAPKSTESSSLLFGKSAPKPEILFGKEVSRELEFKPQGKVLFGKVIELSSRRDHGDVPAKRQLSPSRSEAASKRTLMAFNDPFSSTSSDITDLETFGADTSKKDARQKKPLIKRSGLFGKAIAEASGRSHDSPRGDQPSDSHALTSKTHKSRSRSPEKRKQSPGRSSEDEIKKTRDESKPGRRSSSSSSSSRRFASPEEIKKLQAIVIKGVPPVANSRAYLKDFFSQYGPVTRVFTNAAKHSAIVYFADHDSAAYAKKKARVLKRGTKPVAIFWRQGDPGPKSENRPSQDDHKVSSTKHTESKQIGVRPSLAMFNRKIEAKVNPEDGSSVVKQISSTTSAAGHQKTTNLSVPGHLLSKQVGHTAQDRYDILEDRDRVIRQGLKKKTNLAMPGAIKGTCPDMCPEKERYMREVQRRLHPYEVLQGSTDQVHVNHDAAVKEYSRSSADQEEPLPHEMRPAPVLTMTMNYLMRHVMNTGQDGHWEEWFDFLWSRTRGIRKDITQQDLRDLTAIDLMEKCARFHIFCSHRLCEEDLSTIDPKINNENLTKCMQSLKQFYRDLASEGVVCPNEAEFRAYDVLLNLNDRDILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XU66</accession>
    <name>A0A8B7XU66_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110975343 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110975343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083456.1">
        <property type="nucleotide sequence ID" value="XM_022227764.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083465.1">
        <property type="nucleotide sequence ID" value="XM_022227773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XU66"/>
    <dbReference type="GeneID" id="110975343"/>
    <dbReference type="KEGG" id="aplc:110975343"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270">
        <property type="entry name" value="ARMADILLO-TYPE FOLD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270:SF2">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="460"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083465.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="83649" checksum="86FDE27F25459C61" modified="2022-01-19" version="1">MCMGSKLNTLRHNRSNMDDSQQQQQEVQQPEHQQEQQQQQQQQVKRQEQQQQDNQRAAEKMPPEKQPVRSSPEREKPYNDKRHSPLEAVKEALLQLRVMKEYANLEAKAKIKHIADCFWKAEDQREEIANVFAKEKGAELVVTMLTALSKEGLFKNDSVWFTAYYVYNTVWNLSDASLMCAQCLGEAGMVKLCATNIAHGPYRENMKQKNVAFLIKASLSILHNLSKAPSNRHFYRQERVEAKIQPYTQGCDDNTNDAYLKAITMMTLAYILEEDGDRSQSGDTGIKENSDTINMTTEKSTIEYIVGLLKDAQQSKDRRSQGLSCAELAQGLGRLAVNDHNKSRILQVGALPLLTAMLQQDSLVQEQEAATQAIWNLAFDSTVRQHLAADKTCVDALERLTHSEEQSIRTAAKGALWVGRKQERTAKPSVTSSTTSTVSASSRAPGRSWSRGSSTGSGNLPHIMISYQWAAQKIVLKVRDLLVNSGYRVWVDVDCMYGSTLQAMAEAVENAEVFLLCISERYKESPNCRTEAEYAYQCRKSIIPLMMDKYYQPNGWLGMIMGTKYYIDFSGRHTFSEQAQKLLREICDIGSAALLEEPVFECDASATILENPRNHMVSPRPQTQPSPRQQTTSPFRRRHVSAPVHQMPSPLLESPPSPTQPAHVREWSRDNVQQWLEHSNLSHLRQSFEDFDGSLLAQLQTVRQEAPDFFYSSLRHDLCIQHLVDILRLTEAMDKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUA3</accession>
    <name>A0A8B7XUA3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBC1 domain family member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110975552</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. The TSC-TBC complex acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022083817.1">
        <property type="nucleotide sequence ID" value="XM_022228125.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083819.1">
        <property type="nucleotide sequence ID" value="XM_022228127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUA3"/>
    <dbReference type="GeneID" id="110975552"/>
    <dbReference type="KEGG" id="aplc:110975552"/>
    <dbReference type="CTD" id="51256"/>
    <dbReference type="OMA" id="VMHTMWL"/>
    <dbReference type="OrthoDB" id="18718at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000006">
        <property type="entry name" value="TBC1 domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.680">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039842">
        <property type="entry name" value="TBC1D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043039">
        <property type="entry name" value="TBC1D7_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13530:SF3">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="48"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022083817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022083819.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33710" checksum="0526A34EA1E59A5A" modified="2022-01-19" version="1">MADGRNFRSHYYEKVGFRGVEEKKSLQILLKDDPLDVGKLSMFCLRFPLPAMFRPLVWKVILGIVPPHPTTHDFVMQQRREQCNDLRGALRVMGLVDDGTPLSNEFLKMFLLEERRLPLEDDQLNIECLEEESFVSLAETATDIFDDEVDAYWIAVKIRRQLIEKDFILQLSQRFVTQLQKDDPQLIRHLESTGTLSRMGPVYKAWFGGIFAGVIPSGPLGRVWDRLLGGAVYITAYVAQVFVLTYRRQLLGMAKYDAILKFLLKVPPDSAEMLVNEAIERWESSGNQTKPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUT2</accession>
    <name>A0A8B7XUT2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083992.1">
        <property type="nucleotide sequence ID" value="XM_022228300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUT2"/>
    <dbReference type="GeneID" id="110975650"/>
    <dbReference type="KEGG" id="aplc:110975650"/>
    <dbReference type="OMA" id="IAKCTQK"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF86">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083992.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31320" checksum="2B256876CEDA23CF" modified="2022-01-19" version="1">MAPKVVLITGCSSGIGLATAVCLAKEKQHEFKVYATMRNLGSKGSLETAAGDTLDKNLFIRKLDVTKEDTISSVVDEIVRENGRIDVLINNAGCGGVDGNDQWPLERCQAMMDTNYWGVVRTTRAVLPAMKKQKSGRILNVSSLYGVLGGPFYATYVSSKFAVEGFTESFAPVLRDAYNIRMSIIQPGPVRTEMLANFQKDREESVKDFDSATREMYLVQKKKMKSLVEQLDQTADDIAKLHLEVILSENPHLRYQTSEAGTQIVATKLKDPTTDALLDMLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVR4</accession>
    <name>A0A8B7XVR4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC110975718</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110975718</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084125.1">
        <property type="nucleotide sequence ID" value="XM_022228433.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975718"/>
    <dbReference type="KEGG" id="aplc:110975718"/>
    <dbReference type="OMA" id="LCIERNT"/>
    <dbReference type="OrthoDB" id="10037534at2759"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LDLa"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
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        <property type="entry name" value="GAIN_B"/>
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        <property type="entry name" value="GAIN_dom_sf"/>
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    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
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    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
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        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00002">
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    </dbReference>
    <dbReference type="Pfam" id="PF26588">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GAIN_B"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034402512" evidence="9">
        <location>
            <begin position="22"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1109"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1143"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1167"/>
            <end position="1191"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1211"/>
            <end position="1233"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1253"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1301"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="1329"/>
            <end position="1351"/>
        </location>
    </feature>
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        <location>
            <begin position="260"/>
            <end position="335"/>
        </location>
    </feature>
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        <location>
            <begin position="621"/>
            <end position="732"/>
        </location>
    </feature>
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        <location>
            <begin position="922"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="1107"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1389"/>
            <end position="1410"/>
        </location>
    </feature>
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            <begin position="29"/>
            <end position="41"/>
        </location>
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        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
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            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
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            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022084125.1"/>
        </source>
    </evidence>
    <sequence length="1410" mass="155954" checksum="B4155EA423C02850" modified="2022-01-19" version="1">MATLHTFAWIVSSLLLVDTLCYLVDTQSCHSDQYRCSNGVCIPRSQVCDHYNDCGDQYDSDENPALCSSDSDIYCWDRSFASILCIERNTSGLFQHSFLENDTAIYIFTAPTTYSQYTYLTEVGLNVPAFNLSGLGDKTVMVSISSANCLQTTRIFITDFEQISKKLRVPLHVESEETIRVTIEYFVDIQSRPAVPVNVTCNDCVDLYFRTHFSGCECFRDYAAWRTLIAYRQLWFNVTCSVPETNEIFFSLYDRCLGPPSFEYISPDVTSFLNDEIVLSCVAIGDVAPVVKWVDEEGNVLNSSLNGVYLKTVVTDFPQRFRCVLDDLKISREVTVAKWGPVCEDIYNVKNLRYYRSAPKCYSSRLLRIKSSNFSLIRPVIAHHLTVTHLSPPTLHLKYDARMRSFGNEYLLFYDNQKDGHGTVVRLNDTAEKFDVQLVPPAVLKNGSFEFTLSAKFLNKQFPIPFVAMSAELSVIDCQERDSCDEFFREWTRLETAFVESSCGNGLQQEYLSYLLCRESTSDPGPVPVVSSSARHLIEAPNDLLSNQPFPVVCPIENAASYDWYRINSDGRRKFVTNGCKLIFPSFEDLRDQGAYICVGRGRSPLVTATAEHRTVVLKSGITTLAVNLTLKNETFTDDLSNTSSIAFSTLKEKIRSQLPLDVIYTPVIAYDVVRFYPGSVIVGLKVILSSRINMLDADSVASLQMAISSNASSQPGLNIDPLRVTVVSLSSCPVEVIEIAGRDVTFPQTRVGQNVELLEECIVTGKKGVILISRTCEGDFTQNAHWLEPVLGSCNVNVTGQLDDLKQINVTSDNVEEVAESLYSITSNSSPIDDEALSSVADVLDNILHVRDPSPEVTLNVVSAVNNILQVGSEVFEKLSDGGSTSRIVQAVESQISHVLEDGANFTAVRSTLAVAALNIPPSSLGEGVGFVVTGEISDSVLTNDSVGIYYGSDFPVDETVQSSIRLPGAVLRKHLSVNIPVPISFVVYQSSKLFHSTLIDEAVSSGSLRFVGSAVISATVIGVSVDNLPEDDPVVVTFQQKPLTKGTIQCVFWDSQLQGGVGDWSTEGCRRHASSGGRTVCHCSHTTSFAVLVDIHGQRSPILALDIISKIGCALSIASLVCTIIIYLAIKSLRAKTPSRILVCFCLTLLCLYLVFLVGVEQTSSRAGCIIAAVLLHYLSLASMAWMSVEATNLYLKLVKIFNSDVKHFMIKAGIAAWGLPMIVVSIILAVDYTVYENETSCFLKPSVAFYYGQLLMIGLVFLYNAIIFVLVARRLTCKADKIQSSSKRGKRSKIAKRLQNMVSVSVLLGLTWAFGLLAVIESSTFAFQILFCVFNSLQGLFIFLLFVVRQDKIRSQVLSCFRRRKQNSGKTTDRLVLPVPQCIGKQLPQLSDDDEPKENEEKETIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXF8</accession>
    <name>A0A8B7XXF8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuropeptides B/W receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110975913</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084481.1">
        <property type="nucleotide sequence ID" value="XM_022228789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXF8"/>
    <dbReference type="GeneID" id="110975913"/>
    <dbReference type="KEGG" id="aplc:110975913"/>
    <dbReference type="OMA" id="RIFTYIN"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022084481.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41600" checksum="FCA899FF69666EFC" modified="2022-01-19" version="1">MDPTPLSFSCTGDEVEDYSNSSVPSGYLYNPTDTAITSVVNPCILALGLIGNLAFLFVMLRIRRMWTVTNIYLINMAVADTAFLTIAVSEKLANFYNSPVTLDRSALGRAGCIITYALLDLNYFASVFLVTLVSLEKYYAICRPVQHRVIGGKKRTARLIVGAWLLALAFSLALLPAWAVYVKVCTIWPQTEEYQHFPQHIGKCRAITDWYDEFHNGFQTVPFFLALFSNLFFYVKIIKSLSTRITSVAPEQSARNVQRQKIRNQVAVMLIANGVAFFVCLAPFQLTSFSLTISGLTGNNLLTPDQINTLVWVARIFTYINPVINPVIYNLTNQRYRTAFFEAFTCRAFRKRHEDSTALNEDTLSTFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYT4</accession>
    <name>A0A8B7XYT4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976325</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085195.1">
        <property type="nucleotide sequence ID" value="XM_022229503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYT4"/>
    <dbReference type="GeneID" id="110976325"/>
    <dbReference type="KEGG" id="aplc:110976325"/>
    <dbReference type="OMA" id="LGYILMM"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085195.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="22743" checksum="BDBCA2F7B08C2B8A" modified="2022-01-19" version="1">MMNKTFHFSDKIKDFLFSGCHIESGPDLIAAMGAVFLVAVFLELMKLLNAKLKQRRCKNPLEVGQKSAPRRNSSINGQSSGQQSPLLSSLRIPSSVSKIRQRRLKFHLIEAVLHIFQVTFGYILMLVVMTYNGFLFITVVVALCAGYFFLAPLQRMREPWRVPVRHESLTDSEGKSCGVSSGSVAIVESAEHIQSSRYGTLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y188</accession>
    <name>A0A8B7Y188_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="24 25 26">Solute carrier family 12 member 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24 25 26" type="primary">LOC110977269</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25 26" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>K(+)(out) + 2 chloride(out) + Na(+)(out) = K(+)(in) + 2 chloride(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72395"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:72396"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086929.1">
        <property type="nucleotide sequence ID" value="XM_022231237.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086930.1">
        <property type="nucleotide sequence ID" value="XM_022231238.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086931.1">
        <property type="nucleotide sequence ID" value="XM_022231239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y188"/>
    <dbReference type="GeneID" id="110977269"/>
    <dbReference type="KEGG" id="aplc:110977269"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008511">
        <property type="term" value="F:sodium:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055078">
        <property type="term" value="P:sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000022">
        <property type="entry name" value="Bumetanide-sensitive na-k-cl cotransport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013612">
        <property type="entry name" value="AA_permease_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002443">
        <property type="entry name" value="SLC12A1/SLC12A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF103">
        <property type="entry name" value="SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08403">
        <property type="entry name" value="AA_permease_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01207">
        <property type="entry name" value="NAKCLTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0868">Chloride</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0915">Sodium</keyword>
    <keyword evidence="15" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease N-terminal" evidence="22">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="20">
        <location>
            <begin position="197"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="21">
        <location>
            <begin position="697"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="868"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022086929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022086930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022086931.1"/>
        </source>
    </evidence>
    <sequence length="1109" mass="121142" checksum="0A2800028603CA2B" modified="2022-01-19" version="1">MSDSEACANGDSDQGSAFTLSEEPAEDSSGSGPAACGESEDKSECNMEESGLLEGTGRAARVSSKKHFSSKKKHGRFHVKIIRETDKASSLKRNGDMGKASMSPSQQESVDESLDHSLAAHSFGHTVEAIPSLDHYRNRYSLLASGKQRPTLYELHEPKTAVNQTADTPVDAGGLAEIEAPPTTAASGGVKFGWIKGVLVRCLLNIWGVMLFLRMSWIVGQAGIGFSILIVMMATVVTVLTTLSMSAICTNGEVKGGGAYYMISRSLGPEFGGSIGLIFSIANAVAVAMYVVGFAEVVRDLLVDNGLKIIDPDNDVRIIGEATLVLLLGITMIGMAWEARAQLFLLLLLVIAICNMMVGTFIPAPDHEIARGFQNYRGALLVENFGPDYRDGEGFFSIFSIFFPAATGILAGANISGDLKDAQKAIPKGTLIAIAMTSVSYAGLAIVLGSCVSREATGNIADVIAGNFTTACEDGFDCEYGLLKNFSVASLISGWAPLVLAGVFAATLSSALASLVSAPKVFQALCKDKIFPKIGSFAVGTGPGDEPRRAYILAFFIAAACIAIGELNAIAPIISNFFLMSYALINFSCFSASLAKSPGWRPAFRYYNMWVALLAAVLCMGVMFLINWYAALITIFIVTALYMYVHNTKPEINWGSSNQAFIYKQALTNTLKLNHIPAHVKTFRPQIIALTGLPECRPALAHFVSHITKSTSLLICGAVLTGEQSTNLNELTTDYHEKWLDSQKIKAFPAMVASPTLRAGAQALMQIGGLGKIRPNTIIMGFLGRWKTEKSQYVNDYVGIIHDAFDLNLGVGILRIKESFDVSSALNTPGFSDYVEGVLHQPEHTNSRFRIEKVPEIKVESMVSSIKEEEKEGEEVAEPSATEPPNSPVGTKISMFDSTALIKGKPIDDVIKSMQKFQEKMPKGNIDVWWLLDDGGLTLLIPHLLSMKSNWEKCKLRVFATTGKKEQIDRERMNMANMLSKFRIKCTDVEIISDLNKKPKEESLRRFEELINPWILKEGAGETAEKFPWKITKDEVTTLKEKTTRQIRIRELLREHSREAQLIVMSLPIPRKLTCSAYMYMCWLETLTKDMPPILLLRGNQTSVLTHYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1K2</accession>
    <name>A0A8B7Y1K2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Interleukin enhancer-binding factor 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110977338</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087040.1">
        <property type="nucleotide sequence ID" value="XM_022231348.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087043.1">
        <property type="nucleotide sequence ID" value="XM_022231351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1K2"/>
    <dbReference type="GeneID" id="110977338"/>
    <dbReference type="KEGG" id="aplc:110977338"/>
    <dbReference type="CTD" id="3608"/>
    <dbReference type="OrthoDB" id="5775647at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000058">
        <property type="entry name" value="Interleukin enhancer-binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006561">
        <property type="entry name" value="DZF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049402">
        <property type="entry name" value="DZF_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049401">
        <property type="entry name" value="DZF_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052134">
        <property type="entry name" value="ILF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46447:SF1">
        <property type="entry name" value="INTERLEUKIN ENHANCER-BINDING FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20965">
        <property type="entry name" value="DZF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07528">
        <property type="entry name" value="DZF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00572">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51703">
        <property type="entry name" value="DZF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DZF" evidence="8">
        <location>
            <begin position="22"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022087040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022087043.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42300" checksum="41A1F72CE479D0B9" modified="2022-01-19" version="1">MRSKEQGRRGRGGFKPHGPWRAPFIPHVPFDMIQCEAAFQRVKPVPDDQPLFDELIKKNGELSPTPLEQSSVLSLVTKINTVLDNIIVAPPSGFDVVVEQVRQVGSHKKGTMMNGSPVADLVVILKTLPTTEAVIKLGNKVVESVKEKEPNEVLTMLTNEAGCEISSSEATVKIMVTTIPPNLKKIDPAMHLPLKVMKSSLAAVRHARWFEENAQHSSIKVLIRVLKYMRTRFEGLEPLNPWIIDLLSHYAIMNNPPRKPLAINLAFRRCLSLLASGFFLPRSMGIIDPCEGNGMRAHCSLLLDQQDQVAYTAQTLLRVLSHGGYKQILGTDGNASIATEMSVWDGVVVTPSEKAYEPPAEVPKGEEGEGDGEEEEGMESVESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2L8</accession>
    <name>A0A8B7Y2L8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LOW QUALITY PROTEIN: WD repeat-containing protein 54-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086550.1">
        <property type="nucleotide sequence ID" value="XM_022230858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977063"/>
    <dbReference type="KEGG" id="aplc:110977063"/>
    <dbReference type="OMA" id="WENYICV"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050630">
        <property type="entry name" value="WD_repeat_EMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049546">
        <property type="entry name" value="WDR54_beta_prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720:SF40">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13720">
        <property type="entry name" value="WD-40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21031">
        <property type="entry name" value="WDR54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WD repeat-containing protein 54 beta-propeller" evidence="4">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022086550.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="35103" checksum="5D191290DCE57149" modified="2022-01-19" version="1">MFQKSKPIHMKGTASLLYNNLTVLSSPEKNMTTYAVVHKSVICMASCASDNNSNVSHKQVTCRDPSPTPQSTMILQAKFCQLPSRTLLVLCYQRGIQIFEADGSALVFWHALVHIDPSVGMAFARGIAAVHDSYIAVGTSTAQILVFNIPXRGTNVTLSESLTGHPYAISALAGDGAIMASADDSGCIMVWQAGQSFKRVCRINGGGVTCSSVCLYDGLVIGGFGSGHIRVFDAMKGTIVSEICAHAKWIHAIDIAPTAGLLLSTSEDTFVRVWSISKDGDVTQIQLMFSESVTDTQLTGAQFTSKSGRGFTLSGYDLNEVVCYNQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3G5</accession>
    <name>A0A8B7Y3G5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Trafficking protein particle complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110977694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Golgi apparatus</location>
            <location evidence="2 10">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087724.1">
        <property type="nucleotide sequence ID" value="XM_022232032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3G5"/>
    <dbReference type="GeneID" id="110977694"/>
    <dbReference type="KEGG" id="aplc:110977694"/>
    <dbReference type="CTD" id="126003"/>
    <dbReference type="OMA" id="YMVKFDD"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000005">
        <property type="entry name" value="Trafficking protein particle complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022087724.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21396" checksum="CBCDF85586B6D533" modified="2022-01-19" version="1">MAERRFQQKSSVVDRPLSKGKAEVNISTFALLFSEMVQYCQSRVGSVPELQSKLSEMGQHVGVRILDLLFIREKGLKRETKLLNILLFIKSNVWKVLFGREADKLEHANDDERTYYIIEKESLVNRFISVPKDKGSLNCAAFTAGIVEAILTGCNFPAKVTAHWHKGTTYMIKFEDSVLARDKALDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3Z0</accession>
    <name>A0A8B7Y3Z0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol-glycan biosynthesis class W protein</fullName>
            <ecNumber evidence="5">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8 9 10" type="primary">LOC110977782</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PIGW family.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022087900.1">
        <property type="nucleotide sequence ID" value="XM_022232208.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087902.1">
        <property type="nucleotide sequence ID" value="XM_022232210.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087903.1">
        <property type="nucleotide sequence ID" value="XM_022232211.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087904.1">
        <property type="nucleotide sequence ID" value="XM_022232212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3Z0"/>
    <dbReference type="GeneID" id="110977782"/>
    <dbReference type="KEGG" id="aplc:110977782"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022087900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022087902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022087903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022087904.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="55365" checksum="4CCD90A1BF67AF0E" modified="2022-01-19" version="1">MASRNAKEAFYTNLTGTTPFEVSLAVAVGPASELLRWTLLPILFMVFGNVIRNKWLSFSLDFVTLVIPLLLAFTVWNGSLQRFLISLVVTSATLLVVAYLLQPVRSQRVKRPSKAKAVAAPRPLWELPMESEQLVFMTMFRVHGIVASAITILAVDFPVFPRRFAKTETYGTGMMDIGVGAFMFMNALVSKEARGVHQNIFSSGVTGALKSLTKTVISALPMVILGMVRLASVKSSGYHEHVSEYGVHWNFFFTLAVVIIVSSVCLLVIPPVLSGPLALAIAVGYQHLLSNRGLGQFVLAGSDGQGSREGLLDANREGLVSCVGYLAIYLAGVWTGRFLLKRRTLFFDWWLAFLLLVVINVLLWIFLEASSVYIQPVCRRMANLPYIIWTLCFCIQLLASYMLVDIVLALGKEFIWKSPFKISSSKSGKHPLLPESVLVAALRPNLLLVFLLCNLLTGVVNLSLDTIGQPMPASMAVLVLYMLGLCLVAFGLHTRGIKLKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4S6</accession>
    <name>A0A8B7Y4S6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">RYamide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110977593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087542.1">
        <property type="nucleotide sequence ID" value="XM_022231850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4S6"/>
    <dbReference type="GeneID" id="110977593"/>
    <dbReference type="KEGG" id="aplc:110977593"/>
    <dbReference type="OMA" id="RIGYVIW"/>
    <dbReference type="OrthoDB" id="10053194at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004995">
        <property type="term" value="F:tachykinin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001681">
        <property type="entry name" value="Neurokn_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46925:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00244">
        <property type="entry name" value="NEUROKININR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="53"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022087542.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="44379" checksum="E9D373CE89A0688B" modified="2022-01-19" version="1">MENETELTTFSFPNATDDLDDLELEDMYYKEPVWVQAIFIALYATVSILGICGNGIVCYIVLGHQRMRTVTNYFIVNLAIGDLLMAAMCVNFTVYATLYTRWPFGEVMCKLVSFSQTISVSVSIYTLVAIGVDRYFAIIKPLRPRMGSTETLFVIGVIWVISIALALPTLLFTTVESYGEATFCTDGSWEDSLVYSLICMVLQYFLPLTLLAGAYIRIGRRIWGRRTPGEMEAERDKKMSESKARLVKMFATIVLLFALCYLPIQIYTIVQDSNQDVLKYHYIKIIYLCALLAAMSNCVYNPFIYCWMNIKFRNGFRSVFRFLPCVKYQRNWNGFKGLRRANTGQTQMETMSLGSRVDRGRWWTQDPGKTNKNGRASNSDGETRTSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5F9</accession>
    <name>A0A8B7Y5F9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein BarH-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110978066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088428.1">
        <property type="nucleotide sequence ID" value="XM_022232736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5F9"/>
    <dbReference type="GeneID" id="110978066"/>
    <dbReference type="KEGG" id="aplc:110978066"/>
    <dbReference type="OMA" id="AGYCIPS"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF8">
        <property type="entry name" value="HOMEOBOX PROTEIN CEH-62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="161"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="163"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022088428.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="28948" checksum="F637D9904B7C26AC" modified="2022-01-19" version="1">MEFLHAAGRPEFPYFAAGPHAGKSFTAPAPLQPTHGATPFSIEDILNRRTPGPSSAQPPSGKPAKSPANAALQCATECGEFASQNREKVSRSETCISFTAVPSVPKCLGFATCTAALCVCRERRLGADGDTDQWPFLIRTSAGYCIPSLFPSETTSGTLRSRRRKARTVFVDSQLRGLEARFQAQKYLSTPERIELAVGLGLTETQVKTWFQNRRMKQKKDTAGPKDQRDHHVRPVGTRVGQPVGTCKRDQATAAETMGEEEALNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5U1</accession>
    <name>A0A8B7Y5U1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110978131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110978131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088564.1">
        <property type="nucleotide sequence ID" value="XM_022232872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5U1"/>
    <dbReference type="GeneID" id="110978131"/>
    <dbReference type="KEGG" id="aplc:110978131"/>
    <dbReference type="OMA" id="DHCILND"/>
    <dbReference type="OrthoDB" id="7085216at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038775">
        <property type="entry name" value="SPMIP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35263">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35263:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22593">
        <property type="entry name" value="SPMIP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022088564.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="17757" checksum="300C5C3C4F56A315" modified="2022-01-19" version="1">MSHFNLTHLGYQDPIREKVLQPNPEYRYQLVQDVPKGSYVTFRPPASKLPPIDMHKYNKVIQPGKYEEHGGSYVKFTERLHKHTRTNSAPNEIYRTEITTSMKPGWWSRNDNIHQREPWTHTPRRVLVNSEMTRFVNEMSLTNREFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6S3</accession>
    <name>A0A8B7Y6S3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Protein DDI1 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110977983</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088261.1">
        <property type="nucleotide sequence ID" value="XM_022232569.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088262.1">
        <property type="nucleotide sequence ID" value="XM_022232570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6S3"/>
    <dbReference type="GeneID" id="110977983"/>
    <dbReference type="KEGG" id="aplc:110977983"/>
    <dbReference type="OMA" id="GKAINCH"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartic peptidase DDI1-type" evidence="5">
        <location>
            <begin position="88"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022088261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022088262.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25486" checksum="2C9FE6C66BF24B52" modified="2022-01-19" version="1">MAAEINRPILKGPRVIPPRLTTKSSTDLLPLEMRLGTSKEAQPAAILKKKLVQKLDLPAPPQVRRKSFTDVDDKKRMAALERTEQVAASLLYAQCQLNGDEAVALIDTGQMDSTIPRGIAQAYGLIGVDGKEIIKPTNGATHKSMEIQTDDCRVSTQLRLGRAPLECHLTIVPDNTAVLLTIGMDILHRLKCILDVSSRVLYLDGLSGDAKQLLTHDEVFGDTRLVRSQSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6U3</accession>
    <name>A0A8B7Y6U3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110978327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022088934.1">
        <property type="nucleotide sequence ID" value="XM_022233242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6U3"/>
    <dbReference type="GeneID" id="110978327"/>
    <dbReference type="KEGG" id="aplc:110978327"/>
    <dbReference type="OMA" id="PYFQGFA"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="11">
        <location>
            <begin position="321"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022088934.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="46462" checksum="82CA34368686A2C6" modified="2022-01-19" version="1">MALGRHVPHRWVWRVCRHWFPQLFLLTCFIYLVFYVVTQIEFDAPVSLSRPKSIRQHEDYPWVDDKFAPVKKPPSGADVSDSMQAQNASRSQVKDSDKERQDTKDAWNNEYEPNGFMEQQAAIQMERRSHVNKACSNYPKLSQGSLNMETLRHIYVHEKHKILYCFVPKVGCSNWKRVLMVLAGLREETEGISSNEAHFKNGMKRLSALTPSEQKIRLKTYTKFMYARQPFLRILSAYRNKFADIKMYRKEPYFQGFAKRIMKHYRKDATPRELQTGENITWHEWVTYLTNPTERAGFDDHWQEIYKMCSPCKVKYDYLGKLETIGDDARYMLTSLGLQDQVSYPTKANSHPTNSSKTYDEYFNQVPKATLQRLWELYRLDFELFGYAKPDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y758</accession>
    <name>A0A8B7Y758_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Substance-K receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110977632</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087616.1">
        <property type="nucleotide sequence ID" value="XM_022231924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y758"/>
    <dbReference type="GeneID" id="110977632"/>
    <dbReference type="KEGG" id="aplc:110977632"/>
    <dbReference type="OMA" id="FEPRQGE"/>
    <dbReference type="OrthoDB" id="10037617at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022087616.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="36842" checksum="8CE197E5AAFA2328" modified="2022-01-19" version="1">MASYNTSDAMPEQDPGVNDAVNNALLDAINTIIACLAVLGNSMVISVMLLRPRVFSSFTNRLLLHQSVIDAVAGLLFLLFTVVREFPVVVSREGNEYDQLVCRVVHSAFLLWSVNVTSTYNLVIISLERFMATCYPVRHRNTWSRAKLKFALAASWLIGFLYGSHLLFIFEPRQGECQPVAMGVGLQVLFGAVVVGIEYLIPMSIMVYTYSRILTSLSMRPGNPVSGQPNSLSRAKRNVLVTVLLAAVMFAVCWIPSELTYLNAVFFGDTFGEQVYEASTGVLACNMFVNPVIYCFMYERFRVQLRGLIMRRFRGNRVANELSVTLSTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7B6</accession>
    <name>A0A8B7Y7B6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial 2-oxodicarboxylate carrier</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Solute carrier family 25 member 21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110977676</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71739"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71755"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:72701"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71747"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71763"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71751"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71759"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:36165"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)</text>
            <dbReference type="Rhea" id="RHEA:71743"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087671.1">
        <property type="nucleotide sequence ID" value="XM_022231979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7B6"/>
    <dbReference type="GeneID" id="110977676"/>
    <dbReference type="KEGG" id="aplc:110977676"/>
    <dbReference type="CTD" id="89874"/>
    <dbReference type="OMA" id="LPFQYQF"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 21" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="32"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="129"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="20">
        <location>
            <begin position="227"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022087671.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35649" checksum="16A6C663727E269A" modified="2022-01-19" version="1">MWPIPVTLIVCSSINMPKEVTLGTVTLGDRLKEAGRQIVAGGSAGLVEVSLMHPLDVIKTRFQIQGGPQGEVYGTSMLDVVRRMYHTEGTLSVYKGILPPILAETPKRAVKFFTFEQYKHVFLFGAPAPTPLTFTLAGLGSGLTEGFIICPFEVVKVRLQAEKLQFSQQTSAFSLARRIVREQGIGRNGMLRGLTATLGRHGIFNMIYFSFYHNIKQYFPSASSPKLEFVRKFMIGLAAGTIASSVNIPFDVAKSRIQGPQPVPGQVKYRTCFWTIRTVYLEEGFLALYKGLLPKIMRLGPGGAIMLLVYEYSYAWLQKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7C0</accession>
    <name>A0A8B7Y7C0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Neuronal acetylcholine receptor subunit alpha-10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110977681</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087676.1">
        <property type="nucleotide sequence ID" value="XM_022231984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7C0"/>
    <dbReference type="GeneID" id="110977681"/>
    <dbReference type="KEGG" id="aplc:110977681"/>
    <dbReference type="OMA" id="QRYHHIR"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034248776" evidence="14">
        <location>
            <begin position="26"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="15">
        <location>
            <begin position="33"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="16">
        <location>
            <begin position="246"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022087676.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="56048" checksum="FFE7745943C290C3" modified="2022-01-19" version="1">MERLMMKVASVISAFIFLQVTVCEGATGSVYSKKLFKKLFEDEGYNHNVRPVLSVNTVTEVRMLLYVAQVLDMDERQQTLTTNMWVTYVWKDEFIHWDPEEWGNVTKLKVDSELLWMPDITLYNCAADNYIPYLTKKICIIYNDGNINWASPVIMKSHCNIDVTHFPFDKQSCELKFGPWQYDGTEVNLTGTGDTSVFISDGEWDMKGLDVRQDVNFYPDAPGIPYTDVVYTMHFKRRSLYYVFNLVMPCVLVAGITILGFVLPADSGEKVSLGITVLLSLTVFLLLIAESMPPSSHVPVIGQYYAATMLLVSISIMLTVIVLNLHHRGPTCRPVPRWMRRIFLNKLAPILRLHPRPSQRNKAVSKDHKIFMRMQESETSIMDLTTPLHQNHQTPGDESPIRAMHNTTRNLHRDGPERACCRQQIDILRRMMDHMRVVREHYDSLDHSDFIRGEWKQVAQVVDRLFMIFYILGTISTLLIIFIQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y812</accession>
    <name>A0A8B7Y812_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Galactokinase</fullName>
            <ecNumber evidence="4">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">LOC110978569</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a phosphate from ATP to alpha-D-galactose and participates in the first committed step in the catabolism of galactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022089363.1">
        <property type="nucleotide sequence ID" value="XM_022233671.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089364.1">
        <property type="nucleotide sequence ID" value="XM_022233672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y812"/>
    <dbReference type="GeneID" id="110978569"/>
    <dbReference type="KEGG" id="aplc:110978569"/>
    <dbReference type="CTD" id="2584"/>
    <dbReference type="OMA" id="VMPCAIN"/>
    <dbReference type="OrthoDB" id="275179at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000040">
        <property type="entry name" value="Galactokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000007">
        <property type="entry name" value="Galactokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="18">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="119"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="307"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022089363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022089364.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="43892" checksum="796C18C1595AEA36" modified="2022-01-19" version="1">MHMASSIRMADAGVTKIKVVEELVQDASSVFVEKFGGKPTVAACAPGRINLIGEHTDYNDGWVFPMALPHVTVLVGNKTTSGVCRMVTTAQNADEPKMVEFPLPTADKPLQPGLPAWANYVKGAVQYYKGTLSSFDAVIASSVPLGGGVSSSASLEVATYTFLEAMDPNGPTKDLKAKALACQKAEHDFPKMPCGIMDQFISVMAQEGHALLIDCRSMESRQVPLADPNVVVLLTNSNVRHELTGSEYPTRRRQCEEAAAVLKKQSLRDATMEELLANEGNMDKEVFRRGRHVIGEIKRTTDGVEMLERADYVTFGKLMVESHNSLRDDYEVSCPELDQLVEAATAVEGVYGSRMMGGGFGGCTVTLLRKDAVEKTVAYMKEKYSGTATFYVTAASKGAQILSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y912</accession>
    <name>A0A8B7Y912_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110978385 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110978385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089032.1">
        <property type="nucleotide sequence ID" value="XM_022233340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y912"/>
    <dbReference type="GeneID" id="110978385"/>
    <dbReference type="KEGG" id="aplc:110978385"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022089032.1"/>
        </source>
    </evidence>
    <sequence length="749" mass="86012" checksum="A48D25398B53E0F3" modified="2022-01-19" version="1">MATLSRKVVAVALIFTLMTVLAYLHFSESPMKYFHPVLESVTHPNSNAGEKEHRIVIIGSGPTSLGAAQRLHELQGKYFNTKVTIIEQQDKPGGLASSERDKKGFLWDMGGHVVFSHYDYFDKTLDRAVAHWNQRVRAAYAFMMGSDGKRRFISYPVQNNIEVMDKTDQQKCLVGLEEITRNPSKEKPANFDEWLQQKFGTGLCDVFMRKYNKKVWTVDTTEMNTVWVGERVAVPDINKIKAKIAAYDNGSRLEDSGWGPNRFFRFPRYNGTGGIWQGVASLLPQEWFQFRTEVTGVDLDSKRLFLKNRGDDRRRYTLSYDTLITTEPLDMFVNMLEGKDISLGQMKELVSGLVYSHTHVIGIGLLGKPPKFLSDKSWMYFPDSDSPFYRVTVFSNYSDDHVPKPGTYWSLMCEAAEPKDATNPKYWTKKSVVAATVEALITYGFITSDIVVSKYYRRLDHGYPVPHLNREKILSIVQPWLGAQSIYSRGRFGGWRYEVANQDHSFMQGVEIVDRIVRGIPEETYPDPNLVNTRKNTGRFLQQPLSYEFVIAHYNENLDWLKPFANHSHIYHKGPNMEPPFAVIKWETLPNLGRESHTYLHHIITNYDNLANITVFLQGHGPRKDGGFCFPNPMDYVNNALRNQFCRAAGRTKDWSGLRYTGSMPQDLKSGVLRKSNITLSDVYTAMFNTPHPPSLPRCLKGCFSGTRDNIRKRPKSFYEKLMRFVDFHPNPEEGHYIERLWCVIVNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA60</accession>
    <name>A0A8B7YA60_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">26S proteasome regulatory subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110978139</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088581.1">
        <property type="nucleotide sequence ID" value="XM_022232889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YA60"/>
    <dbReference type="GeneID" id="110978139"/>
    <dbReference type="KEGG" id="aplc:110978139"/>
    <dbReference type="CTD" id="5700"/>
    <dbReference type="OMA" id="QDDTDPM"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="219"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022088581.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49676" checksum="0D6D52E1955FC84C" modified="2022-01-19" version="1">MGQNQSGGPGGGHGDKKDDKDKKKKYEPPVPTRVGKRRRKTKGPDSANKLPKVTPHTRCRLRLLKLERIKDYLLMEEEFIRNQERLKPQEEKDEEERSKVDDLRGTPMSVGNLEEIIDDNHAIVSASVGSEYYVSILSFVDKDQLEPGCTVLLNHKVLAIVGVLSDDTDPMVSVMKLEKAPQESYADIGGLDQQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGAPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYESNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFNIHTSRMTLSEDVNLDEYIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFRKSKENVLYRKNEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAM4</accession>
    <name>A0A8B7YAM4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acyl-coenzyme A thioesterase 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Hotdog-fold thioesterase superfamily member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Palmitoyl-CoA hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Thioesterase superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC110978706</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089602.1">
        <property type="nucleotide sequence ID" value="XM_022233910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAM4"/>
    <dbReference type="GeneID" id="110978706"/>
    <dbReference type="KEGG" id="aplc:110978706"/>
    <dbReference type="OMA" id="WDAQRAN"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACOT13"/>
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        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
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    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="24">
        <location>
            <begin position="54"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00075657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022089602.1"/>
        </source>
    </evidence>
    <sequence length="156" mass="17075" checksum="27AFFCAE39AD0175" modified="2022-01-19" version="1">MAASMSISAFKQIWKMLPSGKNFDRVFNKINMVAVSPGRCRCEMTVEEEHTNGQGTLHGGFTMSLLDYMTFFTVVTGTSGQMGVSVRANMNFLQSAKVGEKVAMEAELVKAGKTLAFTKADLFNAKGDVIAQGQQTIYIGNNVTIQDMIKSKMEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YB62</accession>
    <name>A0A8B7YB62_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC110979180 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110979180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090458.1">
        <property type="nucleotide sequence ID" value="XM_022234766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979180"/>
    <dbReference type="KEGG" id="aplc:110979180"/>
    <dbReference type="OMA" id="ALDSLYW"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="50"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="938"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2369"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="938"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1077"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="978"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022090458.1"/>
        </source>
    </evidence>
    <sequence length="2446" mass="268929" checksum="7F0D71A2A174FA9B" modified="2022-01-19" version="1">MCRIKEIGWQYIIHKLCFWFGYFEGSKISLVITESHSKPANMKQPPATPKTPIAIVGIGCRMPGGVDSPQSFWDVLIKQKDMVSEVPADRWSLDSFHDPDQSNHSKMVTRRGGFVHDIDKFDNTFFKISPREASSMDPQQRHILEVTYEAFQDAGIIPTDLGESCGVYIGVGMMDYAVMLTETSLIGPYMHTGTAHSSVANRISYVFDLRGPSFAVETACASSITAMHLACDAIWNGECTHAVAGGCNALLIPETTVGFSALGVLSAEGKCCPFSDGVNGYVRSEGFGAFILKTLDAAVAENDHIYAVISGSSIAANGSCKSLTMPSGPAQEMVMRNAYERFGIPTSSVHYVEAHGTGTPVGDPIEAEAIGRIFGTQDKTPVKIGSVKSNFGHNECAAGITSSIKVALMLDKKTLAPTINHHKPNPNIDLKGLNLEVQTTTESIKDDEGLYTIGLNSFGFSGAVAHMIFQEAPQRQKKSETPKANWKFGDADQVGRPIILPLSAKSKDALNDLAQKWLEFECDNDALGVVSWQASRRDQHPYRLAVIANSGASCRQSLERFLQGAVSEKVISGTAPQAKPKICFVFPGQGQQWVDMGRKLYRADSVFKESIDRCDSVYRKISGWSLLETCSLFNGNTIDPKTSPYSSVDDALNQVEVVQPAITFIQVALLHLWKHLGVYPDVVVGHSVGEIAAAYACGGLTLEEAISVIYHRSHEQAKQKGTGRMAALRATKEQAEEICKEHEHLYIAAVNAPGSMTLAGNTDIIAEVVQNNPGKAKQLRVTCAFHTPEMDPIKEPFMAAMKGVVNSESGKRDVPYYSTVTGAYYAGSFGTDYWWSNIRSAVLFQPAIEAVLQETKADIFLEIAASNTLLTPIKQIAHALDPKNPPVIINSSLRDKDDLLNMQRAVASIYVNGSHLDWCKITDNAAEWAPVPTYPWQHQSFWLETDQRQKRRLGLDDRTIKGQNGKFTLDMFPFLADHVVGNRIVFPGAGYVEFMIQMGFSQTEQPAFKNINFTRVLPWPEDTDPKKCTLKLGLVKDGAKMHVTCEGNQHSDAQMESLSSKTSETCLPLREIQARCTTEVGSELFYSRLAAVGLKYGPAFQPVEKMFLGDGEALAILNPVADNKQRIQIAHFDATFQLVLSAVGPFSAMYLPVRIDSLQMTTETIPSGEKILAYTKIHEYDSTYIGADIAMLTLDGQLLVDVKGFLAQNFSGNKSDVPIESCVYTTQWQPASAHTLPTSVLSEAMEESNLQKICPDEMDGLLRATEVLKDLEGVCVSYVQNALAKVPSREIDENVAKYITRIKSILANTKTKPVPYRDIPEVLRNVLNMAPELNAEVNLVKRFGDTLPDTLKDPQVGLSVLYPEEALDKYFHESLSATLYYKATSQAVVKSIREAVKHKTVVRVLELGGQSGSLTRMIVEPLKDMGLTEQLEYVFTDGNKKLLQQVQDNLSEFSFIEYKQLDIKKNAKEQDFVANSFDLAICVNALHATNNIHQSASNVRNLVSPDGLMFILENTSMHILADFFSLAAEEAHLLSRQGWVDTLVSVGLQDVKSASTSQEFFYSVFVGRKPAVSPQVKKADNKLLIIQNDNSQFTKKFLQSYKGKPEICKFSTVTSFSHVISEHTTAPAEVMYIYSDEDSKLYALLRLFQAVESYPEAVKRVWVLTTGGNNGSQNPQASLAVGLARAVSNQVPTVPIFAIDFDPSSTVDENVHELLSLMNDDEPGEQEIIIRGGEKHVPRLIHQDLHQVSKVQSKTWRVEQDLKGPRSNNASIDDLAFHDVPDLEIPSGHVKIAVKAAPLNFKDVMMALGLLEGLESDVHPSFGLECAGKVVEVGSEVTDLKVNDNVMAFGKNCFASHTVCDSRLTVHKPENLSWVDSSSVGVIFATAYLSLVDRANLKKGETVLIHSACGGVGLAAIQIARMRGATIICTAGTETKRSYLRNELGMHFVSDSRSSKFYDDVMEWTDGKGVNVVLNSLSGKLLQTGLSLLSPGGRFCEIGKRDILQSSSLPMNFFLENKVFHSCQLDILMKQRPEEVQCVMRKVVSLFEDKTLQPIPTSVYSIENLKETFRVMSKGSHIGKIVFEVPENFQPKDVQPSLCQFKSNATYIVTGGYGGIGQALSRWLCLNGAKHIALVSRRGATTAAAKRTLNFLKKNKVNIYEFPLDISNKAGVQDLLRTLRQNKTTPPVKGIFHLAGVIDEESLSEVTPNQMDRILGAKALGAQHLSELTQDDNLEIFFMLSSISTTWGHQAQPCYCAANAYLDALAESRHSRGLPALSVQLAPVKGAGYLEDKGQTVKVLAMKGCYQLHVDEFLQVLSQLLPRRDLPVVTFANQDWGITQTTCHKSTLKFHHLATRSKGTATKGETQQMELADLETSIKSKMAELLCMSEEAIDISQPMVNYGVDSLVALEIANWATHQLGVEISQLDILGGMTTVELIDKATEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCA3</accession>
    <name>A0A8B7YCA3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgi-associated plant pathogenesis-related protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090873.1">
        <property type="nucleotide sequence ID" value="XM_022235181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCA3"/>
    <dbReference type="GeneID" id="110979412"/>
    <dbReference type="KEGG" id="aplc:110979412"/>
    <dbReference type="OMA" id="YKYCGSY"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000002">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022090873.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18662" checksum="E1AA81A28A04215A" modified="2022-01-19" version="1">MGGCFSGGSSGPSGYRSKFKRDAVKAHNRYRSMHGAPNIKLNGNISKYAQEWANKLAKEGQLQHRSEHKYGENIYYGADSRGLDELTGDKAVKSFYDEINRYNFNSGGFSSGTGHFTQVVWKDSRRLGIGVAVNPRKQNEVFAVFNYDPPGNVSGRYKENVLPSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCT2</accession>
    <name>A0A8B7YCT2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ADP-ribosylation factor GTPase-activating protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ADP-ribosylation factor 1 GTPase-activating protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">ARF1-directed GTPase-activating protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110979121</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090367.1">
        <property type="nucleotide sequence ID" value="XM_022234675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCT2"/>
    <dbReference type="GeneID" id="110979121"/>
    <dbReference type="KEGG" id="aplc:110979121"/>
    <dbReference type="CTD" id="55738"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000008">
        <property type="entry name" value="ADP-ribosylation factor GTPase activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="20">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="344"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022090367.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="56826" checksum="714DFB51B764640C" modified="2022-01-19" version="1">MASPRTRRVMKELRPKEGNNNCFECNGHNPQWVSVTYGIWICLECSGKHRGLGVHLSFVRSVTMDKWKDIELEKMKVGGNNKARAFLKSQPDYDPSWSIQEKYNSKAAALYRDKIATEAKGETWSAATSPARNHVPYVAAKLKTTSSLSSSSGSFHTSRSSPSFSNYNSGGAMIESGGSGGYQSAGKDDFDLMYGMSKSEVDVKKKDYFERLQAENAARPDNLPPSQGGRYTGFGSTPIKQESSSDTWDSAVASLSSGWSTFALSATKFASATKEGAVKFGSAASQKTQEYAAKVNEAVVKPTKEKMQDGRLLNDISTGTKSFASKFAASTSKGWKDFTSIFTDNPTTLDSVDDTPTAESLLMPGKEASEKRERLRQMDPDQSDTPLLHDAPTPPRTPDETEDTNWGWGNTDTWEDTPQIQPSQPKVEESDSWDSWANEQDDLLLDFGDSALTSKKANNGTRKNGSKKSSSSKKVTSLEETWDDAGGWDEAAWEAIESDIKTSKKNSSSSRRNNSKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YD58</accession>
    <name>A0A8B7YD58_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022089591.1">
        <property type="nucleotide sequence ID" value="XM_022233899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YD58"/>
    <dbReference type="GeneID" id="110978697"/>
    <dbReference type="KEGG" id="aplc:110978697"/>
    <dbReference type="OMA" id="ITIAIMM"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="20"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022089591.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="49874" checksum="39B890904D2C1E6D" modified="2022-01-19" version="1">MDLVSKPALYSSSKFRGWLMVGIAFVEIFIICGPTYNFSIIFLSLQDEFNAGATWTGWIGSLANSLMGAAGLISMPLIQRYGPRLVTLVGLVAFGGGLVTTSLVPALAYAYVTFGVVVGLGANFVLQSVVHLLFSWFPEKNCSRAFSLVMLGTSFSELAFAPLLTTLIRVFAWRNALRIIGGGSIILGFVFAVPITSPATTTNHERGTRAKESRDEPCTDMATDAVIPDGLSENSRQRVLEVAWKIDTWLWSLCLVLVYLGWTFVTVNYASFMEHDLQFTTDQITIAIMMLAVGGIVGKILLSLFADRLPCLKLYVVAAASLLGAVVAGLMTWLRSVSLVYIVSLFVGSVRSASNAMPFPATMEIFGEYGSCIVSVLSMVPYGIGILIGAPISGSFYDLTGDYNLSLFVIVAIFVCSSAVALAIPIKKRTQLSSYSFSFRPKATKSSREIPHVYSVSGMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE70</accession>
    <name>A0A8B7YE70_ACAPL</name>
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        <submittedName>
            <fullName evidence="13">Cell adhesion molecule 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110978905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022089931.1">
        <property type="nucleotide sequence ID" value="XM_022234239.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cell-cell junction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="CD80_C2-set"/>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
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        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="IGc2"/>
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    </dbReference>
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        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
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            <begin position="25"/>
            <end position="596"/>
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            <begin position="359"/>
            <end position="380"/>
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        <location>
            <begin position="27"/>
            <end position="135"/>
        </location>
    </feature>
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        <location>
            <begin position="147"/>
            <end position="217"/>
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    </feature>
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        <location>
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            <end position="334"/>
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    </feature>
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            <end position="416"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
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        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
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            <begin position="539"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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            <dbReference type="ARBA" id="ARBA00023319"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022089931.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="65160" checksum="DF4E3193FA51C029" modified="2022-01-19" version="1">MHCVLSSVIQLCVAILIGSGNVYATGPLRENPADAFTTPGSTVVLRCAINNRPGQSPYIVYWYRHSPNAAYLTKGTRVFRQSTTDDSWRRLSVIGDTPAGEYFLQIRDVSMSDAGDYGCVYFEGGKYLGESRIVTITVYEPPHEGYPQCSMEPAGVYLEPGQKVVLTCISSGGNPKPRLDWMSWHEILPGRVEEDPYPKATYELQLMETDNGAVFTCVENTPALPRLARTCSLKPFHRPTNVSIVTSSVNVGEDAVFTCSAVGIPSVTNYTWIIAGKTPENFVSASGEKIVIQDNNQVLRIVNVLSGDNGTVVKCYANNEINEKGDTSTEVFISQLLPSRPSGKNASARDEDNESGMNAGIIVGSVLTLLLLVIIIVLLVRKLICLNIKQESSREKEQEIGEAESQPLKAETTDTHQPVVNIHANPRPVTICLTPRDAIVEHIRETEEAGGQLLRPSDSGSRVTVVGRLSCAGMTVDFGDIGQMYSKPAKKGDTTKHADVVPDPEPQTSKPKPKPAAKPALLPKPKLLPKLGKPLPVQSKEEPVSPKEDDQPKDENGEVIYENTHRRPDITMDLGEEKDPLKPNSTHWNGKKPELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGQ8</accession>
    <name>A0A8B7YGQ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Vesicle transport protein SEC20-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110979911</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091772.1">
        <property type="nucleotide sequence ID" value="XM_022236080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGQ8"/>
    <dbReference type="GeneID" id="110979911"/>
    <dbReference type="KEGG" id="aplc:110979911"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15865">
        <property type="entry name" value="SNARE_SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="12">
        <location>
            <begin position="146"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022091772.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="26956" checksum="46F9F93C15F31960" modified="2022-01-19" version="1">MRDQCLDVTHFSTSPCKIRRVRAHFNFCGCPGVVLEPSDIRSNCHSLQDMNLVNQKIEEQMKRTQNRIQDLERIANEQDKETDRLDILKDVENFRKQLSSTQTSVRKAKLSCKMAIDRQERASLLQGGTDPDLRKRMNKESLAKTAGSITDNLMSLNRMMAANVTQSTLTNQVLEKSSATLSDTHEEFKGMGGVIQTSRSLLTKYNRRELTDRLLIFLGVALFLATVLYILKKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH19</accession>
    <name>A0A8B7YH19_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Neuronal acetylcholine receptor subunit beta-2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110979873</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091690.1">
        <property type="nucleotide sequence ID" value="XM_022235998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH19"/>
    <dbReference type="GeneID" id="110979873"/>
    <dbReference type="KEGG" id="aplc:110979873"/>
    <dbReference type="OMA" id="NEVEYPD"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 14" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034429257" evidence="14">
        <location>
            <begin position="29"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="33"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="256"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022091690.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="57532" checksum="12F42E014F15DFFC" modified="2022-01-19" version="1">MDLSAGRAWWWILTVCLTLLSTGRQLLATEEHTRLFQTLFNANYSHLIRPVKNHDTVTVVEMLLFLAQVIQLDERKQTLKINAWVTLLWEDEYLKWNPEDYNNLKNIKVPSENIWMPDVTLYNNADKYTNWLKGQIAVIDYNGSIMWGCPQIFTTYCKIDITTFPFDEQICKLKFGLWQHDASEVVVVGADKQVNASTSDSGGDETVFKSDGQWDMISMEVHSNKVEYPDDPGKNYTDVQYEVLFRRRPLYYLFNLIIPCMFLSLVSLLTFFLPPESGEKVSLGVTVLLSLTVFLLLVAETMPPTSTVPIIGQYFACTMVLISISIGMSVTVLNMHHRGPDCKPVPPWIKRYILNGIGKVLLPSESSRSKRRPTIGDKLAHELRSWETKSLVAEVTSNSTSSRSRIISNGCGGPNSNGSDDADQDKPSGGGGGGGGDGGLGSVRDSLHRNRSLYLALLREMQKITFSIEVEMNSRRVQTEWKRVAIVLDRLFFLICLVGSAGTFIVFFVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH80</accession>
    <name>A0A8B7YH80_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="9">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC110980325</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022092602.1">
        <property type="nucleotide sequence ID" value="XM_022236910.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092603.1">
        <property type="nucleotide sequence ID" value="XM_022236911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH80"/>
    <dbReference type="GeneID" id="110980325"/>
    <dbReference type="KEGG" id="aplc:110980325"/>
    <dbReference type="OMA" id="ISPPVWQ"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="15">
        <location>
            <begin position="26"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="493"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022092602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022092603.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="62299" checksum="9EDA61EE437A7016" modified="2022-01-19" version="1">MPVSPNPKRKGYDFWEKTLGKPCLLVAPMVDQSELPWRLVSRRHGAQLCYTPMYHAAVFARDPRYRSEALASCQEDRPLIVQFSANDPEDFLRAALLAQDHCDAVDLNLGCPQANAKRGRYGAFLQEDWDTIFKIVNLAHQRLSVPVTCKIRVFEDVEKTVQYAKMLERAGCQMLTVHGRTRDMKGPKTGLANWDIIKAVKQNLNIPVFANGNIQYKSDVDRCMRETGVDGVMTAEGNLHNPAIFEGVQPPAWEMAEEYLELVTQYPCPMAFVRGHLFKLWHHSLTIHQDLRTRLAGAKTLEEFISINQALRDVCEEEIKQAAGQDSNGKMPHWLCQPYVRPTPEETQQRILEKSLKRPLSEENEQENREPFLSKKALKRHQQGKPPVKNVRKFDPCSTCNNPRGLSCVFKLCRACCKEKTRRAVEDCPSHRFYFKTKIERRKYWEAKQAAKALQTMDTPLDTPKDTPTDTPVNAPTDAQLAVPGGRIMEADPFNIPGSTTAEGSLRDKVSGDFQQDTSGTTSAGNDDRVDANMLTAETPSDLPTTIPSEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKZ2</accession>
    <name>A0A8B7YKZ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Protein FAM69A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110981057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIPK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093929.1">
        <property type="nucleotide sequence ID" value="XM_022238237.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093931.1">
        <property type="nucleotide sequence ID" value="XM_022238239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKZ2"/>
    <dbReference type="GeneID" id="110981057"/>
    <dbReference type="KEGG" id="aplc:110981057"/>
    <dbReference type="OMA" id="YMRIKYL"/>
    <dbReference type="OrthoDB" id="8860232at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022049">
        <property type="entry name" value="FAM69_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029244">
        <property type="entry name" value="FAM69_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093">
        <property type="entry name" value="DIVERGENT PROTEIN KINASE DOMAIN 1C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21093:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12260">
        <property type="entry name" value="PIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14875">
        <property type="entry name" value="PIP49_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01299">
        <property type="entry name" value="PIP49_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="FAM69 N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022093931.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48225" checksum="79A316875059F81C" modified="2022-01-19" version="1">MMGWTRLLLNAHIRMGRYSVKVKTLLVLWMLCFIGLWVMYFRYGDPETCSGEQARTFVCDNYDKGVVAGSMCEELCKQTKVTLDGCLAQDTFHQAFTGTLKKPPKQRKNIDEPLYIKQLLNPQREGFNKPASGSSMEDLRIMISANLKRHLGDAINLDRVQSRILNLADSNNDGKVSLPEARSIWSLLQAKEFLMMMVLGESDYIPRLLGFCGNMYIMEGIHAFRLYGAEFPPFVDFVLPNSAQRFFQRKIAPPWTDRAHIVVGLLEFVEEIMEGPAGNLYMCHVNEMGIGYTAYSDVKILRLDGVLTEQAVQSSLRDRTCFGDGDCLLGENCRSPCDKLTGRCTGEMMQPNLQRVCHMLSAYLLDDSPYEILQELQDLLSKCEDLKFGSKNMNMDHSLVLNNLKSLLWKQVSHLKKFSKTSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YM86</accession>
    <name>A0A8B7YM86_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">LOC110980312</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092580.1">
        <property type="nucleotide sequence ID" value="XM_022236888.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092581.1">
        <property type="nucleotide sequence ID" value="XM_022236889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YM86"/>
    <dbReference type="GeneID" id="110980312"/>
    <dbReference type="KEGG" id="aplc:110980312"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF45">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022092580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022092581.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35512" checksum="C97AC069983B0DB7" modified="2022-01-19" version="1">MRFKPGLSVEASRVCVCTCSMMMAFRKLNSSYRGLLSKACLKKQTGTSSLLTSQQARLCAAECGTYTRIEQDGVHQAVAILKMNNKPFNGFNKPFLDEMSHRLDELRSTGSCQGVIITSANAGIFSAGLDISEIYQISQDCAAALWRSLIEFIMRLYGTNLVTVAAVNGHATAGGCLLSLSCDYRIMAEGKFNIGFSATQLGLITPFWVQEMMSKACGARTAEISFQKGLLYTPEQALAIRLVDELQPAEDLMAAARKQMLKWLAVPEHARVRTKSMQRAALIEKVQSSKEEEIQFFANFLLKESVQEAVGKYLETLKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMK4</accession>
    <name>A0A8B7YMK4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Uncharacterized protein LOC110981299</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4 5 6" type="primary">LOC110981299</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094472.1">
        <property type="nucleotide sequence ID" value="XM_022238780.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094480.1">
        <property type="nucleotide sequence ID" value="XM_022238788.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094489.1">
        <property type="nucleotide sequence ID" value="XM_022238797.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094498.1">
        <property type="nucleotide sequence ID" value="XM_022238806.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094506.1">
        <property type="nucleotide sequence ID" value="XM_022238814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMK4"/>
    <dbReference type="GeneID" id="110981299"/>
    <dbReference type="KEGG" id="aplc:110981299"/>
    <dbReference type="OMA" id="LYYVPKA"/>
    <dbReference type="OrthoDB" id="10021290at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022094472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022094480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022094498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022094506.1"/>
        </source>
    </evidence>
    <sequence length="104" mass="12034" checksum="7E211998D579A821" modified="2022-01-19" version="1">MATLQKASKRPWGTITKPDHMGLGHQRLTAYEVEQSVNRLYYVPKARDAKYNRQNPKMTSTDIRKMVERLTSKPTEKVPDSKRVPEGKLREIGILNSFAWKGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNI1</accession>
    <name>A0A8B7YNI1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Uronyl 2-sulfotransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110981521</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfotransferase 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094824.1">
        <property type="nucleotide sequence ID" value="XM_022239132.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094825.1">
        <property type="nucleotide sequence ID" value="XM_022239133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNI1"/>
    <dbReference type="GeneID" id="110981521"/>
    <dbReference type="KEGG" id="aplc:110981521"/>
    <dbReference type="OMA" id="YYEYEFY"/>
    <dbReference type="OrthoDB" id="10019582at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007734">
        <property type="entry name" value="Heparan_SO4_2-O-STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129">
        <property type="entry name" value="HEPARAN SULFATE 2-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12129:SF15">
        <property type="entry name" value="URONYL 2-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022094824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022094825.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="58003" checksum="3D36E28B8E42FBDA" modified="2022-01-19" version="1">MLEQEDRNCLARLPSRKTALVVLIGIAVTVTLTLVHLSGQWVGQRVFKPVHEPSLAHRSKQLLSQKVLREPAKISWKDRQDEDLKSRNKEGTDEPSSHQLKGGFAKEERTSGSMDSSKRPLPSLNSIIGERPGQNLSAVNNVGLLSVPSRGQTEHSFPPPTRKRVDQITALLDPKIGQSVVPTEKLLQGTIRRERVPAATEKLSGEMKWSRRNVYDFNDRDRNAFRGLRLRNKNDRVWKSKEAIIFNRVGKCGSRTIIGILRKLSDLNNFNLVSSTVYNSTAISTEWQSYIVKVMERVKTPYLFQRHLHFVDFTEFNARQPMYINVIRDPLSRFVSNYYFKRFGDGRSNQNFKGSKEAKYRSVTECIIKGYKECVRSGSFYIIPFFCGQRKECRRPSQWALDEAKLNVEKHFVVVGILEDLESSFRVLEKALPQFFTGAVKLLLEPDDKQALKNASTTTKYKEKPSKEAAAIMKKLMYYEYEFYKFVKDRLERQKQQYGIGMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNW6</accession>
    <name>A0A8B7YNW6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain family 10 member A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094362.1">
        <property type="nucleotide sequence ID" value="XM_022238670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNW6"/>
    <dbReference type="GeneID" id="110981256"/>
    <dbReference type="KEGG" id="aplc:110981256"/>
    <dbReference type="OMA" id="THCQESA"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034521866" evidence="2">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="31"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022094362.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21184" checksum="08617C34610823F2" modified="2022-01-19" version="1">MAALLKLTHFVPLIGLILRVNAVCPPNWLEHGQSCYLFTYNRASWQDAKTYCEGQHGNLLVIESEEENAFLEEEMQSWQMTHIWLGCNDINVEGKWICYRGSVNGQEMQFERWGSGEPNELALGINQDCAVLYFNGRWVDEACATGQKATVCETSNAAKSQHILPLTVSHAMPMTCYTMGTDGRLSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNW9</accession>
    <name>A0A8B7YNW9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110981598</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094959.1">
        <property type="nucleotide sequence ID" value="XM_022239267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNW9"/>
    <dbReference type="GeneID" id="110981598"/>
    <dbReference type="KEGG" id="aplc:110981598"/>
    <dbReference type="OMA" id="RISEEKX"/>
    <dbReference type="OrthoDB" id="5986535at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022094959.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33718" checksum="D1FF567090FB8879" modified="2022-01-19" version="1">MSRIVLCLAGCDSDVVPSMQEKVVLRANGLGEKNIEFDMDGLQSLAYTFYRYLFVDFSDGNSDVADIVTAFREVVLDGWSLNLPDGIGDSFQEGHTYDVMVSRFDIFGSMVDELAVPTLNPRLPLKVTFMGERGQDLGEPRREFLRLCLDEIVNRVKTGPDMSRDFDRSQADSYLEKKVYYVAGIVIVEFCFYLLQGLCILQDGPVPHFLCANLALVEGNLADACDKQLSDGLMKTGVLSLMRTFPQCIRLLHNNVPPPALTSKTIISSFEAIFSESGTGIRGKEEMMMGHFVKYVREVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YR56</accession>
    <name>A0A8B7YR56_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase family 16C member 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110981685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095167.1">
        <property type="nucleotide sequence ID" value="XM_022239475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YR56"/>
    <dbReference type="GeneID" id="110981685"/>
    <dbReference type="KEGG" id="aplc:110981685"/>
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    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF748">
        <property type="entry name" value="FI23927P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022095167.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18151" checksum="B391D3DD45A87DED" modified="2022-01-19" version="1">MASFIKILGLLLLPFWYFIESFFKSCRDLFVPVSLRNLKDLSAEVALVTGGGAGLGRNLAIQLAELKVTVVTWDIDQSANEETVCMILDNGGSAYAYTVDISNPEAVYAAAERVKGEVGEVTLLVNNAAIGQFQSIWEVPDDLIQKKMNIIAIAPFWVINVVEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSI0</accession>
    <name>A0A8B7YSI0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein P2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S acidic ribosomal protein P2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110982259</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096248.1">
        <property type="nucleotide sequence ID" value="XM_022240556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSI0"/>
    <dbReference type="GeneID" id="110982259"/>
    <dbReference type="KEGG" id="aplc:110982259"/>
    <dbReference type="OMA" id="MKVIASY"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022096248.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="11600" checksum="A8DC6941BE4BB8C5" modified="2022-01-19" version="1">MRYVAAYLLAVLGGNESPSANDIKKILETVAVGVEDEPLNRVIEQLSGKNIDDVIAQGQTMLASVPTGGVAAAAGAGGGGEGAGAASEQKEEEAKKEEEEEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTL5</accession>
    <name>A0A8B7YTL5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neurogenic locus notch homolog protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110982017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095825.1">
        <property type="nucleotide sequence ID" value="XM_022240133.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982017"/>
    <dbReference type="KEGG" id="aplc:110982017"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003645">
        <property type="entry name" value="Fol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF224">
        <property type="entry name" value="C-TYPE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SMART" id="SM00274">
        <property type="entry name" value="FOLN"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00286">
        <property type="entry name" value="PTI"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="24"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034079872" evidence="6">
        <location>
            <begin position="23"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="23"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="143"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="222"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="381"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="420"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="460"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="499"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="539"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="607"/>
            <end position="645"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVE7</accession>
    <name>A0A8B7YVE7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-splicing ligase RtcB homolog</fullName>
            <ecNumber evidence="10">6.5.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphate/5'-hydroxy nucleic acid ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110982862</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68080"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:68076"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="6.5.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10 13">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Catalytic component of the tRNA-splicing ligase complex.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.8" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022097289.1">
        <property type="nucleotide sequence ID" value="XM_022241597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVE7"/>
    <dbReference type="GeneID" id="110982862"/>
    <dbReference type="KEGG" id="aplc:110982862"/>
    <dbReference type="CTD" id="51493"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170057">
        <property type="term" value="F:RNA ligase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1860.10:FF:000001">
        <property type="entry name" value="tRNA-splicing ligase RtcB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="entry name" value="tRNA-splicing ligase RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03144">
        <property type="entry name" value="RtcB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027513">
        <property type="entry name" value="RtcB_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118:SF1">
        <property type="entry name" value="RNA-SPLICING LIGASE RTCB HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="Hypothetical protein PH1602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 10 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0819">tRNA processing</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="10 11">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="282"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="409"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="458"/>
            <end position="461"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <begin position="484"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022097289.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="61656" checksum="7B4DD96D3829760A" modified="2022-01-19" version="1">MEVGCHALVCVSVADVEPHSSGGSDSLHAVSILLELHWPDYSCCFIEKSEHQDVRMSSGRTYTQELEYLHQLSPNLWQIKKGFVPNMKVEGRFYVNKQLEKLMFEELRNSCGKSLGGFLPGVKQIANVAALPGIVGYSVGLPDIHSGYGFAIGNMAAFDMDDPNAVVSPGGVGFDINCGVRVLRTNLDEKDVLPVKEQLAQAMFDHIPVGVGSKGVIPMGARDLEEALEMGMDWSLREGYAWAEDKEHCEEYGRMLQADPGKVSSRAKKRGLPQLGTLGAGNHYAEIQVVDEIYNEHASKKMGIDHKGQICVMIHSGSRGLGHQVATDALVAMEKAMKRDKIDVNDRQLACARIQSAEGQDYLKAMAAAANYAWVNRSSMTFLSRQAFAKQFQETPDDLDMQVIYDVSHNIAKVEEHILDGQQRTLLVHRKGSTRAFPPHHPLIPVDYQMTGQPVLIGGTMGTCSYILTGTQKGMSETFGTTCHGAGRAWSRSKSRRNLDYHAVLSKLQSQGISIRVASPKLVMEEAPESYKNVTDVVDTCHMANISKKAIKLRPIAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXA4</accession>
    <name>A0A8B7YXA4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine-rich DPF motif domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDPF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095911.1">
        <property type="nucleotide sequence ID" value="XM_022240219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXA4"/>
    <dbReference type="GeneID" id="110982071"/>
    <dbReference type="KEGG" id="aplc:110982071"/>
    <dbReference type="OMA" id="CDMHELV"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042426">
        <property type="entry name" value="CDPF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018785">
        <property type="entry name" value="CDPF1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849:SF1">
        <property type="entry name" value="CYSTEINE-RICH DPF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31849">
        <property type="entry name" value="CYSTEINE-RICH PDF MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10170">
        <property type="entry name" value="C6_DPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01995">
        <property type="entry name" value="UPF0595"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich DPF motif" evidence="3">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022095911.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14430" checksum="DC80959F21D7FD0D" modified="2022-01-19" version="1">MGRSSCPNLFHGYHSTVSVMSREFLFQCFLCDFKSPYDYFGRKPPFVKSVRLIDKAYVLKDPFAPEGRHITVGSHCSVCEQAVCAGQDCSLFYTRWFCLPCVKKNINEFPQEILQEVEKKGSLAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYV0</accession>
    <name>A0A8B7YYV0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-binding protein 42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">RNA-binding motif protein 42</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110983523</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM RBM42 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098523.1">
        <property type="nucleotide sequence ID" value="XM_022242831.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098524.1">
        <property type="nucleotide sequence ID" value="XM_022242832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYV0"/>
    <dbReference type="GeneID" id="110983523"/>
    <dbReference type="KEGG" id="aplc:110983523"/>
    <dbReference type="CTD" id="79171"/>
    <dbReference type="OMA" id="QAWEDNS"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="406"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022098523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022098524.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="55819" checksum="20FDBF604611413B" modified="2022-01-19" version="1">MYMYLVKRTFKMAAPRTSRPHLGRKEDEMDERKMMEEEMNRFEQEIQTGQDEEEADLQGSASPGPPMVPPGIPQALSVLGTPDPNLMNLRFPAPPEITPPAPQPMTTPAPSEPPSLHPPTPGGAPLRFAVLPPPPPPGTIPTSTPLEPPSSYQQPPSTEGQRLPVPGQMSSQPFPPGVQQVVAEAQPLPPRPAFVPHSVRARAPVPAHRPPMNPMHRPQMPHHPVPPFINSLPRPRGPMNFPAMHHPGGPPQGPPPGPMLPPGYPMMPPRPMRMAQPSPTVIQAKPVKFSQTKKEEKTDRPSGTPKVESVTISQQAYKVQSPAFTQPAAASQLPGMYAATAAVAQPAAVDYSTMAQQQQQHQNAEAVAGTSTAEQKKKEKKKKFIRTAASTVWEDDSLAEWDSNDFRIFCGDLGNEVTEDLLAKVFGRYPSFLKAKVVRDKRTSKTKGYGFVSFKDPNDFVQAMREWNGKYVGNRPIKLRKSTWKDRNMDTYRKKQKEKQKLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZA2</accession>
    <name>A0A8B7YZA2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110983145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097835.1">
        <property type="nucleotide sequence ID" value="XM_022242143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZA2"/>
    <dbReference type="GeneID" id="110983145"/>
    <dbReference type="KEGG" id="aplc:110983145"/>
    <dbReference type="OrthoDB" id="5952164at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299">
        <property type="entry name" value="AGAP008005-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36299:SF2">
        <property type="entry name" value="DUF4773 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034547364" evidence="1">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="2">
        <location>
            <begin position="84"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022097835.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21390" checksum="41470A5363F01374" modified="2022-01-19" version="1">MTTMWKLVALAAAVVTVSSSAIMETDLRVLPSKEEQLLELFSEDLAEMTPQEIAQFLLIDSQFVSASEVTGEGVTGKCTLSREALSAECCATLSFKIFWKRHTINACAFVQVLKEVYGLHLKITALGKTLYDEEVSAREPPAICLGVPNIKLVKVCLDFHEVQWSNGFHACVNFEVRVPFKTLLDVRLGCVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1R6</accession>
    <name>A0A8B7Z1R6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Tumor necrosis factor receptor superfamily member EDAR-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110984060</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099548.1">
        <property type="nucleotide sequence ID" value="XM_022243856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1R6"/>
    <dbReference type="GeneID" id="110984060"/>
    <dbReference type="KEGG" id="aplc:110984060"/>
    <dbReference type="OMA" id="AVIERTC"/>
    <dbReference type="OrthoDB" id="6115199at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047526">
        <property type="entry name" value="TNR19/27/EDAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12120">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12120:SF10">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034742276" evidence="12">
        <location>
            <begin position="21"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="13">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="223"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022099548.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="50447" checksum="E118F760AF695098" modified="2022-01-19" version="1">MRSHPAAAVMASTLSVGVLAACLITTAGAPTAVPSCSNLADGTPQFYDEQNQQCHPCERCDPGEGLSEVCGDGLGKNAQCLPCKEGTFSPVSRAHVCDSCRLCDNTQNDKIPCTRTTDRECGPCKPGYFRHDERNDHCVSCADERHIYLYPDCLRSTSPPAGEDPHNRGLRNLTSSSPSPIGSPLRSPFTIVLIVILVIVVVVVVVIVVLTVKFCPPKCVHNNATTRGSPTLENNRTRGSNNSDPQPENTRLITPAPDPSQTTPTGERTQRAIPFEEPPTDDDNEAVPSVPSSVCDEGQTDNDGSDDRRGSNQSSASNTTRDSSTLPGGDPQDKEAKRSQFLERFQQAKKYTKDVTISQMHRADKELLRDHMHEDPQRLHISTRFNFVRFAELFDIPEMEVRKMHSALDVLDYLAAHREVELTVPELCQILYDSHKCCHIVRDLVNEIIDRVEQKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2A1</accession>
    <name>A0A8B7Z2A1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Fibropellin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110983831</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099102.1">
        <property type="nucleotide sequence ID" value="XM_022243410.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983831"/>
    <dbReference type="KEGG" id="aplc:110983831"/>
    <dbReference type="OMA" id="STYWGDE"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002064">
        <property type="term" value="P:epithelial cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060562">
        <property type="term" value="P:epithelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048592">
        <property type="term" value="P:eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048871">
        <property type="term" value="P:multicellular organismal-level homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061326">
        <property type="term" value="P:renal tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000142">
        <property type="entry name" value="Crumbs cell polarity complex component 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000425">
        <property type="entry name" value="Eyes shut homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000279">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000100">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000327">
        <property type="entry name" value="neurogenic locus notch homolog protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000565">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000255">
        <property type="entry name" value="Sushi, nidogen and EGF-like domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="38"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2R4</accession>
    <name>A0A8B7Z2R4_ACAPL</name>
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            <fullName evidence="11 12">E3 ubiquitin-protein ligase TRIM56-like</fullName>
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        <name evidence="11 12" type="primary">LOC110983809</name>
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    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099064.1">
        <property type="nucleotide sequence ID" value="XM_022243372.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022243373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2R4"/>
    <dbReference type="GeneID" id="110983809"/>
    <dbReference type="KEGG" id="aplc:110983809"/>
    <dbReference type="OMA" id="CPRKQKV"/>
    <dbReference type="OrthoDB" id="6265224at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF229">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="199"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="420"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022099064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022099065.1"/>
        </source>
    </evidence>
    <sequence length="687" mass="77579" checksum="D30EAEA469A00B1F" modified="2022-01-19" version="1">MASNTSVKLTGDSDQADRGKGAAAAWEGKTSSLIRNSSRVSEKDEFERDSGDLSVCFLCEGNLRNPKLLPCLHSFCKDCLLKLVRENETSAPIPCPLCRDGNSAIIDDVERLVDNTLMSSLQELKLVKGEPDMNLEQDDISTCEVKCTSCRRSNPATCRCTYCQDFLCETCRLSHQRLKILQHHELIKLDAWIQQTSKVEYKFCPQHSGEPISFYCQPCKVLACKDCIDLDHQNPHHNTCSLLEGAVLCRRTIDKLLTVSRQTEAKFKGAWEILNSMKAELTETTNSLRHEVRDAFKSERDILDEREKEFLTKIDVIEKQREDTVNTHIDRVETILEKLWTAFDMAEILMENGNDFHVLSLEPIVCKRLQSLYKMSPELPNSNLTLIDLTEEQKTDPEEPNSVPQAQAKDMIDTPVWELETSLGDRGSGKGQFDWCKGVAASLDSHAVVADWGNDRVQVFDEKRQFVCVLNSTNHEEGKLSMPHDVACLLDGRFVVIDKSNYAKIYCPKGNFLDRFLTLSEDDTPMSAVELSCVTVDRRSRILIGDCKRNLITVHYVDGKMIKTIPAVGPEHITTTSKDLLVVSCPRKQKVRVMNHDGRFIFQIETYGAGEKLKPRGVACDDEDNIYVVHKERGGEKSVHVFDSNGEYVACVAKNLREPYDVDIAPGGRVIVSDDDALKIFTRRDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z325</accession>
    <name>A0A8B7Z325_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110983865 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099175.1">
        <property type="nucleotide sequence ID" value="XM_022243483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z325"/>
    <dbReference type="GeneID" id="110983865"/>
    <dbReference type="KEGG" id="aplc:110983865"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05382">
        <property type="entry name" value="CAP_GAPR1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000002">
        <property type="entry name" value="Golgi-associated plant pathogenesis-related protein 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034113">
        <property type="entry name" value="SCP_GAPR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="15"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="207"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="408"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099175.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="61327" checksum="80489874430BF7B3" modified="2022-01-19" version="1">MDRAGCTNPEMDLKAFQKEALSAHNKYRAKHGVPALKLSDDLCAHAQKWANHMASTNLFQHSKARGFGENIAMNFNSMTTEFTGQQVTDQWYSEIKDYNFSNTGFQSGTGHFTQVVWKDSEEMGIGKAIGSKGQVFVVGNYRPAGNMMRCYQQNVFPPGSATIAPGSAARATDERPREPDMRSALPERMDRGGGNIRSKVPQADLKQFQKDSLDVHNEYRSKHRVDSLRLSDDLCKSAQDWAEHLAEAGRLEHSKRTDIGENVAMHYSSATTQYSGKEACDQWYSELSKYDFQKPGFASGTGHFTQMVWKGSKDFGIGKAISKDGKVLVVGQYRPPGNMVGRYEENVFPRADGYRPTPSTAQTSKVTRVVRSTQYVVEEPPKTVEHVTRQVGGVKLKDADLSPSDLRTFQRDALEAHNKYRARHGAGGLSHSEDLARRAQDWAGHLAEKDEFKNSGNSDVGENIAMHYSSASTAFSGGEATDMFYRQVVKYDFKKPGFTSGAGHFTQLVWKASREMGIGKAITKEGKVIVVAFYSPPGNVMGQFDTQVSQEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5Q9</accession>
    <name>A0A8B7Z5Q9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110984785</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
            <dbReference type="ChEBI" id="CHEBI:78569"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41969"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100968.1">
        <property type="nucleotide sequence ID" value="XM_022245276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5Q9"/>
    <dbReference type="GeneID" id="110984785"/>
    <dbReference type="KEGG" id="aplc:110984785"/>
    <dbReference type="OMA" id="CVIRMNL"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001574">
        <property type="term" value="P:ganglioside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906:SF1">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0730">Sialic acid</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022100968.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="29986" checksum="F05AD06C2FA6F922" modified="2022-01-19" version="1">MKPLALYVAALGIVATLFVMSAMLSPMVSNPLHYGIISKKTHLLNSNAIFRGLIQRWRALPSSAGPPSVHGTLRFYRSMLNDQAITLKYSSCALVSSSGILQDKGAGQEIDRHACVIRMNLAPVKGHRRDVGTRTTVRVMNFLSAPVAVRVPMPDGAIFVWGLYLDNRTDYYRRKVLEVSKKYGHRTQIVSLTPDGEKHAESLFYFETGRSFDITKSRPSTGWYTMLVALDICEKIHVYGMVPADYCSLPVQAVNSRHLWLYSTPTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7V7</accession>
    <name>A0A8B7Z7V7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Facilitator of iron transport 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110984814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101037.1">
        <property type="nucleotide sequence ID" value="XM_022245345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7V7"/>
    <dbReference type="GeneID" id="110984814"/>
    <dbReference type="KEGG" id="aplc:110984814"/>
    <dbReference type="OMA" id="THVDQST"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022101037.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="29913" checksum="CB85996C155E99EC" modified="2022-01-19" version="1">TTTVVETTVADGTTLDTQTTTQKPTSAATETTTGVETTLADVTTKIETTAAQQTTVAAKTTLVVETTVDDSTISEIETTTAQQTTVAAETTTVVQTTVSDVTTHVAQTTTAQLTSADAETTKVVETTVADVTTSDTQTTTDQPSSAAAETTLVVETTVADGTTVEAQTTTALPTTAAEVVKTTLADGTTIDTVITTAQQTNGAGETTIVEETTVGDVTTLNTRTTTRKPTTAAVKTTFAAETTVAEFTTSQKTTLGGLTTSAIETSTVDGSTITVSAGLLLSDIFLVKVGDGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8Q5</accession>
    <name>A0A8B7Z8Q5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985372</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102043.1">
        <property type="nucleotide sequence ID" value="XM_022246351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8Q5"/>
    <dbReference type="GeneID" id="110985372"/>
    <dbReference type="KEGG" id="aplc:110985372"/>
    <dbReference type="OMA" id="YLHGNTE"/>
    <dbReference type="OrthoDB" id="10089480at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034449676" evidence="1">
        <location>
            <begin position="23"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102043.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17806" checksum="38A3161FC9C85761" modified="2022-01-19" version="1">MNNWPSVAIATVTCLLLSPIACLPLRDVADGNDRRERLNTWLDPSDAMTNQGSKELAESAKSMLLDKPRDSGSVLDLLLALQDPNNPGDHEGFLRKQRQSKVDDYGHGMFWGKRGTWLHHDERKSGRADQQSKRAHDEYGFGLFFGKRDGADYDDFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8Y7</accession>
    <name>A0A8B7Z8Y7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110984933</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110984933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101270.1">
        <property type="nucleotide sequence ID" value="XM_022245578.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101271.1">
        <property type="nucleotide sequence ID" value="XM_022245579.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101272.1">
        <property type="nucleotide sequence ID" value="XM_022245580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8Y7"/>
    <dbReference type="GeneID" id="110984933"/>
    <dbReference type="KEGG" id="aplc:110984933"/>
    <dbReference type="OMA" id="CEDAGCN"/>
    <dbReference type="OrthoDB" id="10099895at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665683" evidence="1">
        <location>
            <begin position="22"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022101270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022101271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101272.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="17688" checksum="05C435365410CC1D" modified="2022-01-19" version="1">MTFLLLCTCTSILLLSGNVVAALQCHTCADVDRHTGKASLTCDDFYLKNHTRELLQGCGEPPSGHTVRCTKFGGQAKKVEPTGATIIMDGVARGCVVLKEDSLPRSRCYHGEEASPWLPSLVPGSEGASVNGLICFCEDAGCNGVVSVQPFAPHLLFMLMALYALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9A3</accession>
    <name>A0A8B7Z9A3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110985090</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101532.1">
        <property type="nucleotide sequence ID" value="XM_022245840.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985090"/>
    <dbReference type="KEGG" id="aplc:110985090"/>
    <dbReference type="OMA" id="PWARKDK"/>
    <dbReference type="OrthoDB" id="5977943at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="1562"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="387"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="732"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="792"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="916"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1330"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1447"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1529"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="756"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="948"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1347"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1461"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101532.1"/>
        </source>
    </evidence>
    <sequence length="1588" mass="171312" checksum="D20941CF36A334AC" modified="2022-01-19" version="1">MQSTPGVGRGVTVDFSEHVPSPTSRHASSQSAVSPPSQKLKPGPASSDMSRLRVAANLGPGFTHSEHPSFRPDSMEPPGSLHQHAQHQQVLHQEYQRQFQPNKPAKQPSANQFEPPGTQGHLPLHAANEKKQWFVNFDQQQQQMIEQQQLHSPTATTAATPRQQTMQQQLHAPAPAPVPPQQHFQRVQILKRSPQPSQQIQLPYQQQQPSPQQMVQQQPKQQPSPCQPLPPQPSQPLQRQQRASSGQPSQQQMFSPTFVPPVFSPPSISPPLIDPFTLQPIDTSKPPPPIGVPLPGPPRHVPPLGPPTTPFSHANPVKLHAERQLSPPQEPLRDLIQMPLSFQPRPKYRVRPEKSKPSPRLGGDGSAFAALPDEVWDSIPLGGGYNPCEDMGVQGPSATFPPAAGDPSLLPQPTGRGSPGQTWQDQSKGFPKQKRDGTEGQKPWARKDKAKGRGITRKDGQGMVGTPPPNKPAGAYGPSNPTRQPPEVVTLALSQEQTKNEYEWQSFKIIRKVRKVLGNLKDEQDAGKAAAEIAEIMKAESGRLACFPWPKEQFVALDEILGWGTERPEAVEAVCKLIQELHGHHPKNFREDLTNTLMKRHMQYIKVSTATNKEKLYASYSSVVGNLFVLSRSANHSFREILDGVLDLIVAKWITCSVQDSEEDPVMLTGVYTFCLRALFIVTGPHLGNQIDERYNTLLRDQVLGNQPRYVKEAMLDLLLLRAVGWKGLPEFKTESSSDSKIGRETGDDADDGPVPEERHSAVEGEKVQEDITHLGGKEISEDMAQTKLGITGGGDASSVGQSRPAVNGGDSMTVTEWTSPSRIGSTAKFQLPTREITERGAIMLDQAPVHAPHIPALPISDGLAATHQTTWQQSGLGAPISTRDSWSPVYLNRPQETMAFSSRGSAANHALMSKPKLRGCGQPAHADIPQGAEQNSPPVAHPYQASLELSSRQPTDGSPTSNSAVPAMPSSGFGPETTIPSDTCPSAQAGAAMELSSTCSPRPTPEDQAMPSTNSNPSTSSASSSTDKQPLSVPTTSTAELTTATSSQVSVTSLCASEQHAEQFRLPDTQQQTDGSASSQLSANNSNNNRSEASAGIRDQQNGEHDDGSRLLSGEEQTSTDGTDFPTGTESGAVHNATEEYGHPERASAGYREPPCHHENFWDEESDSTSDLEQQPPAAWSLGNSRPSEVLLETQGAGESRLGRQSVPSNLDATKDPSQGALHRQAGKGLSSLLHSAAGPQRISPIAFGRGVMRLEPCSRTSGRGSPATGFMTSPLAFIEPTTAPQSLAARKGTGSKGREGTIEQSENETDTKQVLHAGLLQENTVSSTVSLVSNSGPGGSAGKIETQNLGQSQENGVDDDPKAPPDLPVGETTPSEAICVDSVSRPKMSNFQKVLQPAVDITADYFEETNTQDGQRIQDIFRKTGFKVPESERAEQAVVVEGNQAAESNVEPADGIPDTKSQGVSNQGATTRDLLQDVTSPSLGEEPLSGLPCQSTESGEQLIMLCPLCGSDKHRTRQCAVFKKYAPRASTSDGQSDPEEETPSVQKPKRESQFGKTFFCSKCGKEGHLTYDCPVKGHFNIFNQFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9D2</accession>
    <name>A0A8B7Z9D2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099871.1">
        <property type="nucleotide sequence ID" value="XM_022244179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9D2"/>
    <dbReference type="GeneID" id="110984224"/>
    <dbReference type="KEGG" id="aplc:110984224"/>
    <dbReference type="CTD" id="1431"/>
    <dbReference type="OMA" id="VLEWLFK"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06105">
        <property type="entry name" value="ScCit1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022099871.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="51495" checksum="D4310269770236C9" modified="2022-01-19" version="1">MSLLKVLSRRSIFQAKNLLPSLTCGTRSVSDSTNLKDVLADLIPQKQKEVVEFRKSYGNKVIGEIVVDQLYGGMRGIKGLVTETSVLDPEEGIRFRGFTIPECQEKLPKAPGGEEPLPEGLFWLLVTGKIPTEKQVQAVSKEWAARGAIPSHVVQMLNNFPSTLHPMSQFSAAITAMNSDSKFAKAYNDGVNKALYWEYVYEDAMDLCAKITTVAATIYRNVYREGSSVCPIDVDLDWSGNFAMMLGYEDEMFKELMRLYLTIHSDHEGGNVSAHTVHLVGSALSDAYLSLAAGMNGLAGPLHGLANQEVLVWITKLQEELGGEVSDEKLKEFIWNTLKSGQVVPGYGHAVLRKTDPRYTCQQEFALKHLPDDPLFKLVAQLYKVVPDTLLEHGKAKNPWPNVDAHSGVLLQHYGMTEMSYYTVLFGVSRALGTMASLIWDRALGLPLERPKSMSTPGLKKLVGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9M3</accession>
    <name>A0A8B7Z9M3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985567 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102368.1">
        <property type="nucleotide sequence ID" value="XM_022246676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9M3"/>
    <dbReference type="GeneID" id="110985567"/>
    <dbReference type="KEGG" id="aplc:110985567"/>
    <dbReference type="OMA" id="IVIEHFT"/>
    <dbReference type="OrthoDB" id="10072469at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102368.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44115" checksum="CA914E9FB09283C3" modified="2022-01-19" version="1">MDSPHSSPASIGRHSSSLSSSRRRKQMRQSDASSYRMPISCVDSSVQARVVMEQISRERSQKYKDSVVQTVLGQHDGHRKPSDAKPKVKFPNIDERNPATEKNPATSRQINNSTSCEREETFTKMETFPCHASGPSVTSHFEPLSTDRRPGSSNRISYNSALYSTSASSSAVGRMPVGKHHPMQRRPRAAVHKNGAVLRAQPIPDRSHSEGLSRMESCNDNPRRREIRRRYTPDTTLPRRARSQSSGRSITDPPLPQTRKRRGSNLDAGRSQSDQDISGIEAQLKTKPRQRQKTRHMWQSHDGIPQAADSQDPMSPSLSNLGPSDWQLAREKSFEITFPGYDTRFVDLPDRNALYQESDMSDIDRQIESQIHASSIEKCRRWLNKWVLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB72</accession>
    <name>A0A8B7ZB72_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Titin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110985841</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Myofibril</location>
            <location evidence="2">Sarcomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102924.1">
        <property type="nucleotide sequence ID" value="XM_022247232.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985841"/>
    <dbReference type="KEGG" id="aplc:110985841"/>
    <dbReference type="OMA" id="PYHIECK"/>
    <dbReference type="OrthoDB" id="6612025at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031430">
        <property type="term" value="C:M band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060298">
        <property type="term" value="P:positive regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045989">
        <property type="term" value="P:positive regulation of striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000022">
        <property type="entry name" value="Cardiac titin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000345">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDU9</accession>
    <name>A0A8B7ZDU9_ACAPL</name>
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        <recommendedName>
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        <name type="scientific">Acanthaster planci</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDX5</accession>
    <name>A0A8B7ZDX5_ACAPL</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="4" type="primary">LOC110985904</name>
    </gene>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
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            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022103045.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13479" checksum="6D9E87468E6BEBA4" modified="2022-01-19" version="1">MSSNSTKKNDKIILRLIHPMNGNSKEFTFTPSDSAADVAQYVFENWPQEWESDRVSSASILRLIYQGRFIHGNVTLGALQLPTGKITVMHLMARETLPEPNSQGQRNRGKTEESNCCVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF70</accession>
    <name>A0A8B7ZF70_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110986156</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022103500.1">
        <property type="nucleotide sequence ID" value="XM_022247808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZF70"/>
    <dbReference type="GeneID" id="110986156"/>
    <dbReference type="KEGG" id="aplc:110986156"/>
    <dbReference type="OMA" id="DCVAEGH"/>
    <dbReference type="OrthoDB" id="6219513at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000001">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000002">
        <property type="entry name" value="Receptor protein-tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032778">
        <property type="entry name" value="GF_recep_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14843">
        <property type="entry name" value="GF_recep_IV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034132406" description="receptor protein-tyrosine kinase" evidence="15">
        <location>
            <begin position="31"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor L-domain" evidence="17">
        <location>
            <begin position="65"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Furin-like cysteine-rich" evidence="16">
        <location>
            <begin position="201"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor L-domain" evidence="17">
        <location>
            <begin position="363"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Growth factor receptor" evidence="18">
        <location>
            <begin position="505"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Growth factor receptor" evidence="18">
        <location>
            <begin position="683"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="Furin-like cysteine-rich" evidence="16">
        <location>
            <begin position="797"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022103500.1"/>
        </source>
    </evidence>
    <sequence length="854" mass="94092" checksum="301DE9BF7FF6775C" modified="2022-01-19" version="1">MLTGFGDAMTTTYSFIFLLLCGLGMGGAAGQATGINHKRVCIGNAGSTFLDSDFTYQSLKERFEGCTHVEGNLEMKFIRQSHYNMSFLNDIQEVTGYILILLYYPAVLSFPNLRVIQGSTLYNGNQALYVATNYHARLPEMGLRELHLPKLHEIVQGEVTFVDNRDLCYIQTIDWGDMREGLVPWFDEYGTSCTEEHVCAPNCPGGCWGSGPDMCQVLTRKNCSEICDYRCRGPTQADCCHRSCAAGCTGPSNKECLACLKFTMDDQCIEACPPRTVYQPDTFQNKPNPDFRYAYGKTCLTKCPDNAFEEGDTCVHSCSPGATTSNVPGENKCVKCDGPCPKVCDGTEEILYREHFDNGLLSNCTVIRRNIFIGTSSFDGDVFLGKQGITVELLEQLSTVQEVGGHVTIQGSHEQFTNLTFLRNLKKIYGQQLYRNSALYILSSSVQSLNLISLQRIESGDVNIKLNPQLCYADEALFERIGHRDMRVTVSHNRDLIDCVAEGHVCDPQCTPLGCWGPGPKQCARCQNAQIGDTCVASCDFFSQYAASEGTDHTPTICAHCDPECKGGCGGPGPRNCTECLHVKDGPFCRKECPISKYPDEDGVCQPCHRNCVMEKGCTGPGNALGQGGCVACHQALIDQNGVTVLECMPNGAPCSNDSFSFRVGESNILRLLGYSDGQLCQMCDHNCLGCYGAGPSSCRICKKYKREQECADECFAHQFPNLDNICQNCHRECRTCSGGSSPYDCIRCRHFEVLESENTYCAKECPPDYPYDDRKSHCVASCPENQYVNKATNVCMACHQQCLGGCFNDQRSSCFQCRNVRHGPDCLEKCPPGYMNNSGICIVDPSGVVPHMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFP7</accession>
    <name>A0A8B7ZFP7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Steryl-sulfatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110986341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103822.1">
        <property type="nucleotide sequence ID" value="XM_022248130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFP7"/>
    <dbReference type="GeneID" id="110986341"/>
    <dbReference type="KEGG" id="aplc:110986341"/>
    <dbReference type="OMA" id="AAKWRDW"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.550">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF49">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="53"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022103822.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="68389" checksum="9244CEBB2CD1538B" modified="2022-01-19" version="1">MHLVLNITDSQQIFNIMKLCSGASHLTLSTRFLIMLIFAWTLALAVDGRTRPPNVLLFIMDDVGMGDIGCFGNDTIQTPNIDGLAKEGVKLTQHLALPLCTPSRAALMTGRLPIRYGMGAEGRMRVFVYLSARGGIPSNETTMAELLKEVGYSTALIGKWHLGISCIDKDSCSDPNSQGFDYFYGLPVTNLRDCGTESTVSYAWAKPRRVYTKMGYSVIGALVAAIFLKWVNIVGCRGVVMFLFVALAANGSLLVYWKAIRINCVLMENRRVVEQPLQYDHLTERLHNRAIHFMESHRHQPFLLVMSFVQAHTALFNNNRFRNHSVHGRYGDNLEEMDWSVGEVLRSLKNLGLENNTFIYLTSDNGGHVEEFTDDDVREGGWNGIFKGGKGSTWEGGIRVPTVVKLPGVIPAGTVVSQPTHLPDILPTVARVTGVTLPTDRLYDGRDLMPLLISNDSSKVVHEFMFHYCGSFITAVRYTPIGGDITYKLHFTTSRLVPGIHGVMGCFQTYTCDCTGSFTDRHDPPLVYNLTMDPSETSPLDSSNPRVQGVVGKVGEAVARHRKTIPQQQLHQFGILQLFPRPWDRPRCGSFPFYSCTDPYLVLLKTRKKQATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZG57</accession>
    <name>A0A8B7ZG57_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dynein axonemal heavy chain 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110986432</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_022248280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986432"/>
    <dbReference type="KEGG" id="aplc:110986432"/>
    <dbReference type="OMA" id="CIEWQRY"/>
    <dbReference type="OrthoDB" id="5593012at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000005">
        <property type="entry name" value="Dynein axonemal heavy chain 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001112">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000223">
        <property type="entry name" value="Dynein heavy chain 3, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000006">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:005585">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="13 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0243">Dynein</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="15" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="22">
        <location>
            <begin position="1292"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="22">
        <location>
            <begin position="1573"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="22">
        <location>
            <begin position="1925"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="756"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="2769"/>
            <end position="2834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00069442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022103972.1"/>
        </source>
    </evidence>
    <sequence length="3990" mass="455155" checksum="484AEB7FDDD35C92" modified="2022-01-19" version="1">MAARVNGHQAGSRGTQNGTKPLANGVPRLPPINTPASVLSSSNKDYSQSKLMKHRRAKEMQGLLTDILYKNAKEVELDIGDSNRKRPPTAQNPSYPTSMMSKDRMHRQNYLFMKQCVESSPVTTMEPHWFQDILSLIPDHLTQNPKMQEFIEELFQEVKENWTSSMKKSMVQHVLIKPDIKGLENINIGELPEEPVGLDYSRPWHESFVEARELMTRSLHITHPSMQTVLRLCQNSLGRLILVDLSNLRSQGPVECEHLKNNVILECEKMEEKQMHSWWPEVLNVFVDRKNFADVHPEELESFYNCTSTLISNQLKDLIVRSIDAWVDLFDPADKSRLPIFKMELTYDNDKMEFYPYYSDLEDCLLFVIGQLTKTMQGVPTVQSWLSGTNDLSNIDVAIADHIVAEAKRKLKEACKLNFEGPTEHLQSYLDRYEYLCNGEALSKVQAFMAEDHTFDEYCKLIEEFRSKAREIILQDSIVHFDMVRLDCEDLKRGLAEKSRSFADMLLDRMASDHRKENESICNEFETIKERALKVPEDSGEMMDMIAYIEKARVEGIKALNERIGVSKQRMNYLLDVYFFSQEHIDLNCTVLLWPKNIQPVFDENDELVEASKRKGERELLEKREKVMVELEKIRKRAAEFAEYGELDMMVQYVNDVRAVQKRIAEATETIGFINKEEKLFKWDATTYPEVEEITVAIEPYMKLFSLVVKWQRAEKKWMDGAFMELDSESIGNEADEYWRDIYKITKTFLAQKKKRDAEKAKAAPPKKKRIGAEEGEEPAEKKEEEEEGGAGLKVCNTVQAQIKEFQEYIPTIAIMCNPGIRTRHWSQMSDIAGFDLTPDSGTTLRKVLKLNLDPYMEKFDSISAAASKEYSLEKAMNKMVEEWDQVQFNLTTYRDTGVKILASVDDIQTMLDDQIVKTQTMRGSPFIKPFDKEIREWEEKLLRVQETIDEWLKVQSQWLYLEPIFSSEDIMQQMPEEGRLFQIVDRNWKDIMKHTVKDPKVLAATSLTGILEKLIDSNKNLDNILKGLNAYLEKKRLFFPRFFFLSNDEMLEILSETKDPLRVQPHLKKCFEGIAKLEFLPNLDIVAMFSSEGEKVKMTSVISTTEARGAVEKWLLQVQDVMLVSVKDVIEKSHQAYAIEAREDWVQEWPGQVVLCVSQIYWTAEVHEAIRGGPQGLRDYHDKLESQLQDIVALVRGKLSKQTRITMGALVTIDVHARDVVLDMAEKGVENENDFNWLAQLRYYWENNTVMVRITNSLVKYAYEYLGNSFRLVITPLTDRCYRTLVGAYHLNLGGAPEGPAGTGKTETTKDLAKALAVQCVVFNCSDGLDYLAMGKFFKGLASSGAWACFDEFNRIELEVLSVVAQQILCIQRAVMTHQETFIFEGTELVLRDTCFVAITMNPGYAGRSELPDNLKVLFRTVAMMVPDYAMIGEIMLYSYGFVDARNLSVKIVTTYRLCSEQLSSQFHYDYGMRAVKAVLAAAGNLKLKFPDESEDILLLRSIIDVNLPKFLSHDIPLFEGIISDLFPGVVLPKADYQVFLNAVEEVCAKRNLQCVDAFREKIIQTYEMMIVRHGFMLVGEPFAGKTEVLHVLADTLTLLNERGLNEEEKALYRTVNPKAITMGQLFGQFDPVSHEWTDGVVANTFREFASTETPDRKWVIFDGPIDTLWIESMNTVLDDNKKLCLMSGEIIQMSNSMSLIFECMDLSQASPATVSRCGMIYLEPSNLGWRPVFRSWLNNLPETLKKEEPLFIALFEWLLEPAIDFVHRNTKEYVPTSTNNFARSLMYFVNMFLADNIKPETDLKHLRPWIISTVFFSLVWSVGAVGDTDGRAKFDEFLRDILSGKNEQHPYPGEVGTKLDVPFPTEGLVYDYMYDFKARGKWVHWNDTIKGASIGEGRKVQEIIVPTMDTARYTYLMDIAIRHKRAILFVGPTGTGKSVYVKDKLMNNLSKEEFLPLFINFSAQTSAGQTQDIIMSKLDKRRKGVFGPPMGKRSVIFVDDLNMPAREVYGAQPPIELLRQFFDHGNWYDKKDTTKIVLTDVQFLTAMGPPGGGRNPVTSRFLRHFNIIGITPFNDETMQRIFSTIVSYYLRANEFAPDYFTAGNQVVAGTMEVYKQAMANLLPTPAKSHYTFNLRDFSRVIMGVLLIKKQAVENKRSFTRLWVHEVFRVFYDRLVEDKDRLWLFNIAKTLVKDVFKDSFDAVFEHLAKDGRAVCEDDMRSLMFGDYMNVDAEPEDKIYEEVKSVEEFNQVVEGGLEEYNNTHKTGMNLVIFRYVLEHLSRISRVLKQPGGNAMLVGVGGSGRQSLTRLATSMAGFHLFQPEISKSYGKNEWREDLKTLLKNAGAFGKTTVFLITDTQIKEESFLEDIDNLLNTGEVPNLYAVDEKQEIMEAVRPIAQAGDKNADFSPLALFAFFVNRCRENLHIIIAFSPIGDAFRNRLRQFPSLINCCTIDWFQAWPEDALTRVANKFLETVEMEEEERKEVVDICKHFHTSARNLSVSFMEELGRHNYVTPTSYLELISAFKTLLGKKRDETMKAKRRYVVGLEKLAFAESQVGTMQVELKELQPQLVVAADENQKMMVVIEKESVEVAATSEVVRKEEEAANIQAAAAQALKDECESDLAEAIPALEAALAALNTLKPADIAVVKTMKNPPSGVKLVMAAVCVMRDIKPEKINDPAGTGGKILDYWGPSKKLVGDMNFLNLLKTYDRDNIPAHIMKKIRTEYIPNPEFDPVKVAKASSAAEGLCKWVLAMEVYDRVAKVVAPKKEKLREAEADLSETMTLLNAKRSELRAVEERLANLKQQFKDMTDKKEQLEQQVDLCAKKLDRAEKLIGGLGGEKDRWTTAAANLQNIYDNLMGDVLISSGVIAYLGAFTSAFRQRCTSDWTKLCTMKKIPSSDEFSLSKTLGEPIKIRAWNIAGLPTDAFSVDNGVIVDNSRRWPLMIDPQGQANKWVKNSEKDNNLSVIKLTDNDYMRILENCLQFGTPLLLENVGEELDPSLEPLLLKQTFKQGGVECIRLGENVIEYSQDFRFYITTKLRNPHYLPEVATKVSLLNFMITPDGLEDQLLGIVVAKERPELEEERQAMVLQSAANKRQLKEIEDKILETLSSSEGNILEDETAIRILDSSKVLSDEISKKQKIAEETEMKLNESRAGYRPIAKHSSVLFFSIADLPNIDPMYQYSLMWFVNLYINSIHDRXGEAWPLDSLYLERAVMAVMARGLVMMLTFSPFFPCYDSVFEKFKQHFAAVLCCIFLKKEMDQEEFMFFLTGGVGLENKLENPDPSWLSDRSWDEICRMCDRQAFKGFRDHFQDHLEDWRALYNSKEPHRETFPAPWSEKLSDFQKAIVIRCLRPDKVGPLVTDFVISKLGQKFVQPPPFDLAKSFTDSHSCAPLIFVLSPGADPMAALLKFAGDKGFSGEKFNAISLGQGQGPVAAKLIEAAKQDGTWVVLQNCHLAVSWMTALEKICEDFTPETVNPDFRLWLTSYPSDKFPVTVLQNGVKMTNEPPTGLRMNLLQSYLSDPISDEEFFASCPGKEGAWEKLLFGMCFFHALVQERRKFGPLGWNIPYGFNESDLRISIRQLQMFVNDYNEVQYDAVSYLTGECNYGGRVTDDRDRRCLLTILADFINPQIVSDPKYKFSPSGIYYAPPKSSYEEYLEFIKGLPLSQEPEIFGMHENVDISKSLQETRQIFDSILLTQGGRASAGGGKTDDVLYEIAHDILSKLPKDYDLEAALKKFPVVYNESMNTVLVQEMERFNNLMRTIRSSLQNLQKAIKGLVVMSSELEAVGSSLLIGKVPEMWAKRSYSTLKPLGSYITDFLGRLKFLQDWYDNQKPDIFWLSGFFFTQAFLTGAMQNYARKYTIPIDKCGFEFEVLPCETVDKPPEDGVYVNGLFLDGARWDRKKGILAESMPKVLFDPVPVIWIKPGKKAEFKPKADYVCPLYKTSERRGTLSTTGHSTNFVLPMELPTDKPVQHWIKRGVALLCQLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGW6</accession>
    <name>A0A8B7ZGW6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein mesh-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110986872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022104834.1">
        <property type="nucleotide sequence ID" value="XM_022249142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGW6"/>
    <dbReference type="GeneID" id="110986872"/>
    <dbReference type="KEGG" id="aplc:110986872"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF59">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NIDO" evidence="7">
        <location>
            <begin position="106"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="6">
        <location>
            <begin position="486"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="8">
        <location>
            <begin position="646"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022104834.1"/>
        </source>
    </evidence>
    <sequence length="930" mass="102725" checksum="E94A9E93133509B9" modified="2022-01-19" version="1">MASANCVVRLLEGKSFCIFVIFLAGSYVSGKTLLLPFGAEEGDSYLHPNDDESSGSIQISFNFPFFDHNHGSLFVNTNGVLSFLVEVSQFTPSPFPLDGDRRLVAVFWGDVDIRHGGNVSYRELHRAASSEGLFVRADSIIRQAFIGHSRFLASWMFIATWNEVPFYGAFGEALQIRNTFQALLVTNGKHAFAIYNYEEIRWTTGTASGGNSSNGLGGTQAQVGFNAGDGFNFFVVPESRTDAIVDIDKDSNVGTRGRFVFRIDNSDIVDSGCNTDGTGSLTIFPVYSSMLGGDIIRMSGPCLNETSSIMCRFAGVNVTGQVVSNTTAICVSPPVFQIGRVSLKMSTNNGESFDFSGVFTYLSPEDVSPLVTRQEANDWYKQESLTVTWDTESLQDYVDFVRVSVYSYDENLTTGEVKLYLVNCSSQMVPYSNGEFSFSRPNPPEGVQYEVGAIRVSQYSQHEDTDLELALPGLWSDVHNLHWLYPVSNHSAWCQDWLNDEGSDVNFLQVTEPCPCTQTQAQFNFNMFSNDPSCNSVEGCESFRPGAVECVRAERPSSSGGGQECCYGEDGNILNVAQTTGGGFAQRRHHRGVTPFQTAGHVPLLSHWMSDLLPREHCCLFSNQTMCDAYVSVRPSQTCENYRAPVMAISTGDPHLTTLDGKKYTFNGVGEYTMLEACNGSFVFQARMTVLQSGGAATVITALAAIESGRSDQIHVEVSERRGIDVWYRNMRSDSTWLMLHIDETQIRQVDLQGVIVIFKKANDTVKAVQVNFECGASFIVSTTAGLLNVMTALREELKGRTRGLYGNWNGEENDDFERPDGTVLSTDATVQEIHYEFGQQWQIKPENSLFRYPAGKSPSDYSNEAFVPFFWSMSDPIDNRVLNLCGNDTQCAFDFIVTGNENIAMATKEVVENFGIAVESAAIGKFQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZH72</accession>
    <name>A0A8B7ZH72_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104225.1">
        <property type="nucleotide sequence ID" value="XM_022248533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZH72"/>
    <dbReference type="GeneID" id="110986568"/>
    <dbReference type="KEGG" id="aplc:110986568"/>
    <dbReference type="OMA" id="YWPEFKA"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="58"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022104225.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49025" checksum="5ACF9F26B430A46A" modified="2022-01-19" version="1">MITRMQRATSPFWAPVMSLFDNAVIGWLTSHFCVWWRRKQPPTQGFVAPGFEPVAELFRKNFETGVEHSTGGSAFSVYHEGSKVVDLWGGFADTDVRQVWKEDTMTVIFSATKGIAALCIAMLVDRGLLDYDQKVSFYWPEFAQHGKKNITVRMLLNHEAGLAATSQPISLRQLKDQDALGRLLAESPPRWSPGVGHGYHAFTFGLYCSQLLMRVDPQHRTLGQFFKEEVADPFDIDIHIGLPLELNYRVARLTGIIDSPLRLSYIPRDVGSWHIVWAFLTGRSFIHEVIHKSTDLIKFSKLIQPEARALENPSCSGIGTARAAAKVYGILANGGQTPDGQRLLSDELVEGILTKAGPPSVDKVVGVETNFSSGFLLLKCEGSQQFGHPGAGGQQCVADPHYKLGMGYVSSHFSPYGLGNDPRFLSLQKATYQCIRNLEAKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHV5</accession>
    <name>A0A8B7ZHV5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Otopetrin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110986735</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the otopetrin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104582.1">
        <property type="nucleotide sequence ID" value="XM_022248890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHV5"/>
    <dbReference type="GeneID" id="110986735"/>
    <dbReference type="KEGG" id="aplc:110986735"/>
    <dbReference type="OMA" id="NRVDMGA"/>
    <dbReference type="OrthoDB" id="6429739at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015252">
        <property type="term" value="F:proton channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004878">
        <property type="entry name" value="Otopetrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522:SF32">
        <property type="entry name" value="OTOPETRIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21522">
        <property type="entry name" value="PROTON CHANNEL OTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03189">
        <property type="entry name" value="Otopetrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="472"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022104582.1"/>
        </source>
    </evidence>
    <sequence length="656" mass="73874" checksum="AFA4DD6BE1A9358E" modified="2022-01-19" version="1">MHVVPYRGANFGVGGAHPGQASSLGRGQRYRQDYNRVDHNRPPSLNLASLQKNFSALWDRTKRKVEKAYNIVYAPEPPEDYRVQEADETEMGTLELSLRYPTGVHIGVEPDTHQYNERLMEDDHDDDTDDVWTLLSMMHAMMVVTIVIVLDTAQIFLRYSDGQNAVTPAHVEGFFIMLYLIAIAWILVVVVLKRPLPSSDDEERTDAEAGSRYLYVGLLFFGTGSCLWMIMRTATYIELSGKNCGNQGVFACGNILCVAFTMLQIYYFWRFSKYCLVRWKPVAKLAVMHLMATNAALCVRTLVEETWEDFLLDYLKSSMTKGDGGYTGKLGHLVSDSSAMGHGNLYSKGYSYNGTFNNTGGYPIDPCYIGKTAEGLSGAVYKASVFLYSFTIEYTIIAGAMAYIMWQNIGRKVHHPHKEPSNRQFNFSFECGLLVGVLCTMCGVIILILNIIYLGDYEKRDQSFMSYRGYRVFLNIVCIVACVGAFIGIHKGGWQQDHHSGPAHRVDAALLLICVSGSLLQSTYTFVAAVSSLSQIHSGLVFFDDFTHIIQTVLQCVLILDAMHRKPPADFRHTRTKQLLMFLLVSNITWWLISTYELKGGYDLYALENGYYGATSWYVIVHLAAPLEILFRFHSTACFFEVWNLPGVEANGGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIA2</accession>
    <name>A0A8B7ZIA2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">MAM and LDL-receptor class A domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110986825</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104742.1">
        <property type="nucleotide sequence ID" value="XM_022249050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIA2"/>
    <dbReference type="GeneID" id="110986825"/>
    <dbReference type="KEGG" id="aplc:110986825"/>
    <dbReference type="OMA" id="AKFQIAF"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033996660" evidence="12">
        <location>
            <begin position="28"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="14">
        <location>
            <begin position="42"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="14">
        <location>
            <begin position="218"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="384"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="14">
        <location>
            <begin position="433"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="14">
        <location>
            <begin position="597"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="13">
        <location>
            <begin position="761"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022104742.1"/>
        </source>
    </evidence>
    <sequence length="877" mass="96206" checksum="8CD21A74E1177977" modified="2022-01-19" version="1">MQIYNRSSSRVMFIKILPLVCIGLVISSTTGADVADVLYSEIQCSFKPPRLCDWTSETAPGITARWKRVDFLTTIIDSISDPSTTGLGYGPFSDHSGDTYYAAATGREGQVARLLTPMIEGNPDAPVTVVSFWYHVGSTTANLTVSIIHEDQTKPSRIIWALPKEGVALGRGDPWLLARHTINYPAKFQIAFDAEMQNNETEYFGLDDVLLQTGPVVKTCDFEGNIFGDLCQFYQAGLAESSVDDFDWTLQSGETPSLDTGPLFDHTLGKGGNGHYLFIEATRPEEEKTAVLYSMEYSKLSVSPCKLEFFYHAFGSDIGGLNVWLPGQEYAISLTSEDSWKKYELDLTHVVGTFRIAFQGMRGDGNLGDIAIDDISLVGDKCTGFDACTSSPCLNGGICTPDGDSFTCECLGWDVPPICERGEDPVQNATTEIQCDFLPLDLCGWQSEPVEGEVTATWARQYVLLTNVGPLTDHSGDEYYARTAGTEGTLSRMLTPMISGSRDAPHTVLTFWYHSSSARSNLTVKIVHEESSKPMETVWSFPAGGVSMERFDPWQKARMNINYPAKFQIAFEARMTDSNNAYLALDDVLLQTGKVPQSCDFEGSLYGDLCFLDQVSHNTVDQFDWTRQSGQTPTAGTGPMYDHTFGQDKIGRYMYIEASNHTAGDKAILDALKFYKMEGSACKLEFYYHSLGSNLGQLNVAVSDQVNQVPLTSQDVWKKHEIDLKNVAGPYKITFEGVVGNGPQGDIAIDDISLVGNDCMEVDMCASSPCLNGGTCTPTGTSYTCSCRKGYPGSHCEAPPVYEPMDTMTIVAICVGCGCAFIVLLVVVYLMWSSCRGNRGSKEYEVDDSTDGTQLAMSNDGLEAENNEREKHGEVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJ46</accession>
    <name>A0A8B7ZJ46_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Contactin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110986973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105037.1">
        <property type="nucleotide sequence ID" value="XM_022249345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJ46"/>
    <dbReference type="GeneID" id="110986973"/>
    <dbReference type="KEGG" id="aplc:110986973"/>
    <dbReference type="OMA" id="CIRDQIN"/>
    <dbReference type="OrthoDB" id="6138780at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF54">
        <property type="entry name" value="FI24025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="58"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="161"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="244"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="327"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022105037.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="56504" checksum="9CBFB32D766163A5" modified="2022-01-19" version="1">MTVNISTTNVTDGSLVVDSENDVGKYTCFASNEFGTVVASTIQVEFAFLNQFNQTQIDGSTFYVNESDWLILPCRAPAGHPAPVISWTRNGYPLFANGSSWDPDHGLAQDGAGNLVFLRASLANNGTYRCIVQSTVTKKSIFSEEKTVVVRKVDATPWKPPQILESVRVVKASLGEDVKIYCLAIGNPAPNVSWTRSDDPSFHAEGPVLTLHSVQMRDEGTYTCTASSTNMADQTTSLRVEAAPYWIEKPRDTTIRKGETAEMSCIAGGKPTPNITWMENGESMPQYDGLSSIVVEDMKVYQCVATNDHGQIIANAILNVTGPRRPAPSGVIATVKSRESALISWQPINDTHLVRYKIFYKRKDRKKWKSKDCGRRTQCTLQGLKKDGKFDFYVVAEYDNGDKEGSREFSFNLQPKDLHRFEPPVLFSMFNTAFYCVIVLAVSTPIIMCVILCIRDQINGYDPESPTPSDAFAPAKPNPDPPEVKVETVPRQDGAGPSQPHAKYGKGTTSVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZR17</accession>
    <name>A0A8B7ZR17_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110988538</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107849.1">
        <property type="nucleotide sequence ID" value="XM_022252157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZR17"/>
    <dbReference type="GeneID" id="110988538"/>
    <dbReference type="KEGG" id="aplc:110988538"/>
    <dbReference type="OMA" id="NHGVHCF"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF392">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="15">
        <location>
            <begin position="42"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="16">
        <location>
            <begin position="298"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="14">
        <location>
            <begin position="501"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022107849.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="75040" checksum="2B68DF97DF686331" modified="2022-01-19" version="1">MAQPQHDTMITDDIGAGVIPQIVNPLLQQERDRATLTKDLVTRMTYMIDGGQDRTARRRHIESCLFADPVFSERDRYIRTSVETFDIGVERSIRLIDFKKVHNITFSEVWDYIYRALSNDLTFGVHDLMFVTFIENQATEEQKERWLSKAQDVQMLGTYAQTELGHGTYLPGLETTATYIPSTEEFVLNTPNLSSMKWWPGALGKTSTHVILMAQLIIGGKKYGPHAFMVQLRSLKDHSVLPGRSVGAIGEKWNLGGVDNGYLALNNVRIPRQDMFMKYSEVTADGTYSKRGNPKVLYSTMMVVRLKIAQESWQSLGRVLVTAIRYSAVRKQGPIEEGGPEVAVLDYQTQQEKLFPGLATAYAFNAVSKRLQEVFDKVQADISKENFSGLPELHALTCGLKAFTTDTATRFVDTARYACGGHGFLLSSGLPYSFSRLSAGCTYEGENTVMMLQVARYLLKSAYAAQNGGTLASSIAYLAEDNSGQTWPAQTVKDVTDCGLLCKAYQHRAYRLVSQAGQHVTQLMGKGQSQGAAWNNSTIDLVRAAKAHMQFYTVAIFFDVMKSLNVDPAIRAVLQTLSCLYAVYMMDQSIGDFLEDGYVNADQAQMIHAQYLALLSAVRPEAVPLVDAFDFSDMTVHSVLGCYDGNVYERLYEHALRDPKNKTEMGASQWDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSE7</accession>
    <name>A0A8B7ZSE7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-related protein Rab-23-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110988514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107790.1">
        <property type="nucleotide sequence ID" value="XM_022252098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSE7"/>
    <dbReference type="GeneID" id="110988514"/>
    <dbReference type="KEGG" id="aplc:110988514"/>
    <dbReference type="CTD" id="51715"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04106">
        <property type="entry name" value="Rab23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001204">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034114">
        <property type="entry name" value="Rab23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022107790.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31947" checksum="6D4258C120B94E80" modified="2022-01-19" version="1">MSCSGDLRNNAVCRSGSQTKQILTVFGIGESTVRSGIETKISRTPANWNSPIFLRRWFDGVVIVGNGAVGKSSMIQRYCKGIFTKDYKKTIGVDFLERQIQVKEEDVRLMLWDTAGQEEFDAITKSYYRGAQAGVVVFSTVDKASFEAVEKWKRKVEEEVGCIPLVLVQNKIDLVDEAVVAPEEAEALAKRLKLRFYRASVKENLNIDEVFLYLLDKYMQKLQTQEAEDNATTNTKIGIFNTTVPPPSNDGDSNGGNDQDQTIQLRPTKQRTKGKKQQMKCQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSZ6</accession>
    <name>A0A8B7ZSZ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110988899</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108539.1">
        <property type="nucleotide sequence ID" value="XM_022252847.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988899"/>
    <dbReference type="KEGG" id="aplc:110988899"/>
    <dbReference type="OMA" id="NCTARND"/>
    <dbReference type="OrthoDB" id="8825892at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="69"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="159"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022108539.1"/>
        </source>
    </evidence>
    <sequence length="835" mass="90862" checksum="3199DFDB51FCE4D0" modified="2022-01-19" version="1">MVMTEGVSATLTCTADKGYPNDWKLTWSNGTTDIDGTTTVPEDSSSSIYRFMFSSILNLTPARDDNDPPVFSRLIQFPVNPVLEGSDVILNCTVDANPRPRNLIWEKQDSKKILNTVYTDETSTLTLLNIKRGQSGNYTCRANNGLPADDTLNDAVSDPVTVIVHYEVNITNKVMDEVGIKDSADAVLVCVAIGNPKPVMVWYGLNNTVLTGDTEAKFTVTSATTGGDRVFGYEVTSNLTIKEVNSQIDYGLYTCNSSNGIGKEDSLEIALTGTRRPDKPGRVEITERTAESLTVTWTXGKTTYTVTGLEDYTEYEIRVYAKNAIGENTDYAKVVGHTLPNPPGPDTGITVEYNTDAGTLKVTELKVENGCIQLEVKYEGNDTWQECGKCIHADQTLRLSEWCAASQKRRRRAIGDIEDVRAKLCIDGLCSEAAPVKEVITTTTPTPDNRGIIVGAVVGGVVLLAIIIALATYLVRMSPKDQKSRRKKTTDSFSNGSDIELQSPSNVAGPEEGNGIANEGVQNHVVYAQVNRANKPTAPLITRPARNIATEYDKLSRKERHPVYPNPAVRGDSLPPKTGAYEEMKVAASKTCSENATNKVQENVEKSSPEETTNKVTNRDSKPPITRPKPKSIKKDQPPSRSADEIPKRKAELAGATETTETDGSMADGKPRTTSIKRYTVESGDTYAQVNKNLPPKPKGINPPQNLPDVTYASANKDQKPSLSPLPEDYGAKKKPKKYVPPSARAAEESAYEEVRINDNDNGKSPSAEGDGNTYDGVGAQQDTGGRTANDDGLIYVEVGHARVHPPDQPPIQTEPSTEYASLDFSHMSKKEDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZT99</accession>
    <name>A0A8B7ZT99_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">CCA tRNA nucleotidyltransferase 1, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16" type="primary">LOC110987879</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106699.1">
        <property type="nucleotide sequence ID" value="XM_022251007.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106700.1">
        <property type="nucleotide sequence ID" value="XM_022251008.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106701.1">
        <property type="nucleotide sequence ID" value="XM_022251009.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106702.1">
        <property type="nucleotide sequence ID" value="XM_022251010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZT99"/>
    <dbReference type="GeneID" id="110987879"/>
    <dbReference type="KEGG" id="aplc:110987879"/>
    <dbReference type="CTD" id="51095"/>
    <dbReference type="OMA" id="NLCPKPM"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050264">
        <property type="entry name" value="Bact_CCA-adding_enz_type3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46173:SF1">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="10">
        <location>
            <begin position="75"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="11">
        <location>
            <begin position="233"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022106699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022106701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022106702.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="51960" checksum="D9A35ECC5A12E255" modified="2022-01-19" version="1">MCLSSLWPVSITLQRALQLTVRQAKLSFSSPNCSRPASTAADSMKLDTPEFRAIFTPELKQLAEIFRLNNHELKIAGGAVRDLLMGKQPQDIDFATTATPAEMKEMFEQEGIRMLNTKGEQHGTITARLNNRENFEVTTLRVDRVTDGRHAEVEFTRDWRTDAERRDLTINSMFLGLDGTLVDFFNGKEDLEHHRVAFVGDPTARIREDFLRILRYFRFYGRIADQPNQHCSETLQAIQENGDGLAGISGERIWLELKKIVTGNHAASLMECMHDLQLTQYMGLPPLTNITNFRRVWARSKSLDPKPMTFLSSLLKTDVEVLQLEARLKISADERKTALFIITERDDKYNASNPLKPYQDLVVSLQGKEKNILAYTQEVLKYRGDKELLERLSSWEIPRFPITGKDLITAGVPKGREFGQILERLRERWMESNFRLSKEELLKTLDHTTKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTL6</accession>
    <name>A0A8B7ZTL6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc transporter ZIP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110988690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108150.1">
        <property type="nucleotide sequence ID" value="XM_022252458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTL6"/>
    <dbReference type="GeneID" id="110988690"/>
    <dbReference type="KEGG" id="aplc:110988690"/>
    <dbReference type="OMA" id="GMNCFAG"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022108150.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33425" checksum="64280DC0F1A7BB35" modified="2022-01-19" version="1">MAFSDYTVTAKLTAALVLFFLVFLCSWLPGRIITLLHRGLDNSLDQQRLQQVLTGMNCFAGGVFLATCLLDLFPEFRLLMTGEKGQANSMNSRGFQVSEANTRTFAYRQKRLIPKLSPSKENEIINSCEERQFVYDTPLNRLRRHSSLIKPDSDDNNNCVLTKNLSFVEEQQKRRSLDLSVILLLLVLSAHCIFDGLTVGLDPQPTPQALEVTVAVAIHKCVFAFSLGVQYAQSTQITTGLNRSILCYSAASPIGIFTAFVFELMASHLASLQAMLGSVVPAIATGTLAFKIFQDISPATCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTY7</accession>
    <name>A0A8B7ZTY7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110988898</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108542.1">
        <property type="nucleotide sequence ID" value="XM_022252850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTY7"/>
    <dbReference type="GeneID" id="110988898"/>
    <dbReference type="KEGG" id="aplc:110988898"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034973538" evidence="2">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108542.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25976" checksum="6D0AB3024A642FFB" modified="2022-01-19" version="1">MKLLALFVCVAFLYGVSSETSDLGDGATVVAADDATDDRAVAVESDDFTEDDDTAEMDDEADLEWDDDQDDDQTDDDLDEEPAFPLMYEDQDTDALETATSPDPEVEGHGRFKCRGRRCCLSRRRFHVCVRASYRQGKIRYKATINKKHVVRKSFKVGANQSMRCIKIRRGWSIFRRRRRVCVGLTSIRVLGKGSCIRHISARVKVQVKGPRGFTRKSKRIRLYRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVA6</accession>
    <name>A0A8B7ZVA6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110989168 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110989168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109022.1">
        <property type="nucleotide sequence ID" value="XM_022253330.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989168"/>
    <dbReference type="KEGG" id="aplc:110989168"/>
    <dbReference type="OMA" id="HLYGTSD"/>
    <dbReference type="OrthoDB" id="10036029at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050991">
        <property type="entry name" value="ECM_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026876">
        <property type="entry name" value="Fn3_assoc_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708:SF2">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46708">
        <property type="entry name" value="TENASCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13287">
        <property type="entry name" value="Fn3_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="895"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1669"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1873"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1990"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2106"/>
            <end position="2202"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2232"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2604"/>
            <end position="2699"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2729"/>
            <end position="2828"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2921"/>
            <end position="3028"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1112"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1337"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1465"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2067"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2697"/>
            <end position="2721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3448"/>
            <end position="3565"/>
        </location>
    </feature>
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        <location>
            <begin position="1112"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1358"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1372"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1474"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2067"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3448"/>
            <end position="3479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3495"/>
            <end position="3509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3523"/>
            <end position="3532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3547"/>
            <end position="3565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109022.1"/>
        </source>
    </evidence>
    <sequence length="3565" mass="391345" checksum="E0F9BE6BEF919D9C" modified="2022-01-19" version="1">MGTGASKDTAATLMPTHKSKKNSDSNRASKLHPPKKGNTGTTDTVRIGLTKLGFSPAEVTVSEGQSISINWNAALGSNGHNVRQVVFDGQAVHSVQGGYNSGPLTQDGNFDIQFNLQGEFSFKSDGYEANSSKVLHVTVKSRHYVLAELTEERFVPSVLHVEQGNCVKWVWNSTHQAHSMQEVRLCPKHYGILQTNGGTSVPMQSGSYKHEFQNPGLFYFQTEGHEDGEMQLCVVHVKATQRHHCVEVTDRRFQPRLLTITQGDRVWWLWDRFKCKKKHRIQQMEVPTGPSVSDPFPRPVKGGFSSDAPSRAGMLSHIFQEPGVFYYCDNNYDDNREYLGVVIVKPRAKEHNVEVTAEGFYPDLTVADGGDRIWWNWEVDNVQDNFSVMQVDSCVASDNKTVAEVDCNNLCTHLTPKAATMITRIGLATVQLNTPGVYHYRVSDTPITVGCCSVIVNPGQKDHCISVKDTGFEPKVLRVHPGDRVWWAWENTKQQHNIFQVSRHGHPTKEGFCSGQPQDSPAAFVRQFNAGAVVYYQSVALPKLYGAVVAVSQPQIHQVLVSKNHLQPDPVLAQTHDCVAWVWPVLRKHGLTQLTNTQQVFELQTYTQDVVTPRRCCALRFSNPGVYHYYSKAFSNKTDKFMYEHSSKTVLSSVVVSNPSGPVTVLVSSKGFKPAAISINRGQGVLWSWKGSHSETHNIVHVNPPSHERPYSPVAGPLAFSSGNPEPNNSFLFTFEEPGTFFETSEGAPGCVGVVHVLDDESLSAMPIITSSSNGGVVERLHNVELQSASQTATILYTLDGSIPELHGQATRVYKSEKGISLRQPGLHIIRALAIDNGALPSKVFTSKRFWVLEGNVGHGSEDDDAVSMATDDLEAEMQNSGPGPTNKWQWWNCVPSISGWLHSGSDNSLEIYWDLPSIPYRGQLKSYQLYVNGICYHNDLPPTCHSITVDGLTGNQTYIISILAQPRDSTLLQQESNRLKVTCPSIYELGGPILSCEVTDQEDTINLVWTSLDYLYTEPTKYLIYVDGRETPGEIKTIGDCKKCQLTLPQREVHQAPLTLFIVTLPGEKQNESDGFLSNELQLPLPLCLDNIHLPNGGSLAGKPFLIIKEGRGKPPDAKADLLPSIERRESFDGSVSTLTRGNTPHEDIKDAAPNRSMECEETFNCTGTEVQTNAQPDTQADSDPPHQPESDSVSNACIGPSMEVNPCGTQHPPQNSGTDHGKPDTSERGAWDKNSAANDAAGIVTTSRVPVSTDENHTHTDTYTSKDQDNLETQSLPQQAKHQVPIPEAPEIVENSDQVSDIQFPTHGENEQVSMKSKARIQDEAVLDDETGAVFEPSVENGGSAPLPNADTVSDMADHIGSDSELHSVEPQSLKKTLPAQPQNDYQSDRDNDDDDDMHATRAAETGQSMLHANNVSCCGPSHDVLQVHENGAVGSTTRDKARARLHDQEEAPVLQASVCAHQPAAEQAAPESEHQERGKKPDFKDQTWSTSDNLHDGSGSVALHGDGTSDVDKEPLHDECVDACSLGEGDPSKEPVKAQHERVSLPKPVVSVHSRPTNTDLHVRWQTASCHPTPYVLHHYSVCVAGRQFDGSITSHSRQEMSTDSGEAEVQHCWNAGRGQVFVVTGLSQNTAYSVTVNATYHHKDSAHQSHVKRSSHPIVCTTGGPPLPPRLWAKAVGLQEVTLSWLPGHCHEDIDVMGYQLTRNGKVTSEIIPYGKTEKTIKNLKPDFKHCFSLSMVTTNAGQTKASNFVTVTCPEVPDAPAIRQEPSTEEKSAVIVWHQQKSKQLTHYQVYVDGRLHGEVQPKTNKKHAYLKYTLLNLKANGRQYKVAVRAHAGWSSLKGDQPTEVTCGVLSPESNLLTVACSRALPVSLDLRLECIHSDSVDIMWAVLDEDEASEVQGFIILKDDHPHSGSILPPSITHATLSNLKPGSALTVQVLAISQSLSNDSGEEPITDDEIEEALKRCPPNLILQSHVLQVDYDGLVPAPSRIWCELVTSHSFMVVWDKGKKQRRHCAAPESYTVTWWELSKKSGEPPQSKVTSDDHLLIDGLDLGTKYCITVQARGKRTQPHRGKGRPDSASYEVPVLSQTESITVTTASPPEPPSQLTVASVGSNTVQLKWEPPTEKGAEVIGLRVYVTMQSNNSVQTVQHADLLPDATSAIIKNLQESSTYSLHLVTITDEFFDKDNSPSESPRTKLRGLPEDWSLVPKDSIWLPCVSVDTTTTGVSPPSDLSCTFDCSDTVTLNWRASAHEQRTLKKYEVQWAEVKSTGALTSSSDPHQVIEIPNGEGTTSCEIPGLNKGVRYCFTVVAVITELDSGKQNLKGSKKKGRKQSLQAKENLIRLASEPYVIRIPAPCIAPYVLVTGFGLSWVDVYWEKPPLVTVLTNQENDSCSGCIHRTLLGYLLSINGTTYARLKPTTQQYTINCSPGKTYEIGLTAITTTDKNVSKKLSIGGRGHSWLDSAELEGLCDRATSEPLTVTLPKQQSGNVVKLSAEFHPSSERQNDDSDENNDLRGDIHLEWVLQDCGTAEEQGIVGYDITWLNDADVEERVATLPHTATNYDIPVYHSKCVYTMSIHATQYDDMWQGVPTPSIQCVIPGPPDPPRLCCTSVLQEEFILEWGEPRMYGGVGIRGYQVYMNDKKVGQELSSSHYKAAIPCRPNRTYHMSIVALSADPSYRDSDLSEEVRITCWSPETRPTQPPAAAGTVQRDRYSGQGDGRGKGLLCPEDISIGVLDLTETSIVLEWRLPLIGLESQELVDRIKVMWSSVAKPKELEVVLKPTATQYTVRGCMPGTNHFVAVAAMDKADRVLHRSRLVTIQTTAPLSAPHLRIRSCTYSGCILEWDKPTQFGNAHLAGYQLRLNGKDHDRLPAGASTYLFTAGKMCKEYRFTMQALCTIPHLHSQASEPALVTWPGILPPALHRAATTKLNAIRVSWPEPKVTGGAKVEHYKVMCMEESGTGHKALPPKQRQPLKTLGPLPLDQRWAEFPHLSPHAAYTFLLDTQVSGVGKAVRSRPLNKQYVARRPAPPKVRVTVRGLEERRALEMEACQLVNMRHRLLQELISYQQGSNPGQPPGAVENEDFSAEISDALSALAEMEDQLFQVLETLIPYTGTVAVDVEWDPVRESKDVNLSGFKVLVNDKQSGHLLHSHMDRICLQLSAYDGLHKISMVAATDHPVGNSEPSDVTVIDTSPFLPFTCYCLHSVHRNDSRHPQEGCCSYQQTLALEASPGSPSSTLAALHQQLDPASRRIPPASVTVLDVSDQAPHLLVPTKLTNRCPTMLLFWTHWCLASQKVMDYFVDYARSRVGKVICLTCCCSSTESSSSAHLETLAQLIIRRGWKDDALIRHSCSCGTGDIGLMPGSRASSASTDRGHVGEALSGNEKGTLGVSSSSVVSVAELFGILATPMLVILHPEGYLAWQGCFAACNKNAFATMMDETLDTVVKPSRVSSPRSNSPKLLSRSTSVSSCTVSSLPPHQATPLRRADSNPTASLSRNASISTNSSSAFLPSQLNGSAPRAKSARRRRTTPRQKMISVDQRPFSATKENGSVTASGRPKSSITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWK9</accession>
    <name>A0A8B7ZWK9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110989606</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022109809.1">
        <property type="nucleotide sequence ID" value="XM_022254117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWK9"/>
    <dbReference type="GeneID" id="110989606"/>
    <dbReference type="CTD" id="121410123"/>
    <dbReference type="OMA" id="FSFWSEE"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022109809.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39201" checksum="64747B95BF307E02" modified="2022-01-19" version="1">MTTEPLMPRESGKLIASKSQDVTISEDGACNIANTIFGSLKKNEYSVKIWKQHDLHPKLITKETLDWIFVVDTLNFSFWSETNDKRFLVDYRGGTHSGYWALCAAINRALDEDIPITSPSYYSSITMDQLRHIFRSATDTDIPLLDKRLEHLHEAGSVLLEKFGGSFVNCVSQCENKASKLLHLIPENFPSYRDVAMFEGMAVSLYKRAQILIADIWACFEGKGYGKFSDIEILTMFADYRVPQVLNYFGVLKYSSRLQEILHSGRLFTPGERLEVEIRGCSIWAVELIRQKLKDLMTQDSSLSGLTLNSVIIDFYLWDYSKDHWRDMQHIPIHKIRSTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX84</accession>
    <name>A0A8B7ZX84_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110989742</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022110019.1">
        <property type="nucleotide sequence ID" value="XM_022254327.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989742"/>
    <dbReference type="KEGG" id="aplc:110989742"/>
    <dbReference type="OMA" id="HACHHET"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001891">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF560">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="381"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="627"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="800"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="910"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="1097"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="518"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="521"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022110019.1"/>
        </source>
    </evidence>
    <sequence length="1186" mass="132886" checksum="DCA2B5FD380E974B" modified="2022-01-19" version="1">MTSPLDQWYWLIRXTGCADKLVLRLPEESGIDRTGVFFSEMIKNNTSTRIHIVILAKGNNVHVRPIQLTQTANIGEFVMLQMRDVNSPSTDYRWRHNGGVIIESWNNLLNVSIPNVTVESEGIYACFALYQEMKQLHGIMRLIVRGCPFGCWDPPSCLKTCRRCYNGGVCDDKSGTCVCPPGFNGDSCERAHGRHIFGKTADQRCSSSTDPHHDACRGRLFCLPDPYGCSCAAGYKGLDCMQDCDDGTFGADCKQTCHCAPGGTCSKDTGECSSGCASSYFGSNCQCSPQNGVLGLEVTSGDPHQLFVTWQPDPCASGYELTTRNECEDTVSQQLILENTYHLVTGLELPLSHRVYILPVYPDDERGPEVTFPQATKPTAAPSNVNFTSATPYSLSVSWSKPPCGSRGGIIIGYTYKLTEVSPESQVVIRSMTSEESVTIEGLTPLTEYSFQVAANTTVGAGPYSKASRETTLKVPQVDGTPVPGSSSAVAGGVTATVVILILLVIVAIALYKRQSRPTKKPYDTDGDVSLKGRDVHFLPDPVQETPSSAHATVNPVEICPDPPPTPKPKPDLKPRRVSTNSPKETQEQPVVDEDEEELPYAELPSVREENLAEYIRSKDKAGEKGFPMDFKGLPKGLLHPATVAEKPENKTKNRYANVLAYDHSRIVLQPLGNDPHSDYINACFIDGYDKTDKYIASQGPNKGSLADIWRMVRQYDVDKIIMLTNPVENGKVKCQQYWPDTGSKIYSDVQVKVAEEKTFVDYTIRLFKVVSDEGSRLVKQFHFKTWPDMEPPEYPTTLLNFMRVVNKEHNKGRTVIHCSAGIGRTGTYIALDSMLDQMQKERRVDVLGFIYRMRQKRTKMVQTPEQYRFVFDALLAASMTGNTAYEITDFRRQLTALKEKAKGAKKTGLEKQFETLLKLLAMKRSTERETPQAGLRPENVDKNRFADFPAKQRSRAVLMTSVYKNDTDYINAHFLPGYHKKSMYISTQMPMPNTVADIWRLVYDYKVGCIVMLNPLDPANETMCQYWPEKTGSTIEFGPLLVELTETKEYDNVRQRVFTLRNKDHKTEEEPRTVCQFECLDWPSDADKPTSLHGMLNLMGLTQKWLDKDTPIVAHCIDGVGRSAVYCAIMSLLEQSKEEKLVDVFQAVFRLRMAHHNVMYSVEHYTLCYEILQLYLDSNVIYANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXG5</accession>
    <name>A0A8B7ZXG5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108241.1">
        <property type="nucleotide sequence ID" value="XM_022252549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXG5"/>
    <dbReference type="GeneID" id="110988750"/>
    <dbReference type="KEGG" id="aplc:110988750"/>
    <dbReference type="OMA" id="TAGYCID"/>
    <dbReference type="OrthoDB" id="10221790at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="905"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="995"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108241.1"/>
        </source>
    </evidence>
    <sequence length="1022" mass="108587" checksum="C8BAE2A8DAE7A499" modified="2022-01-19" version="1">MDSISDLTVSRFDSNNPSDILPPDEPFTSTGEFGPKLIIAFSEPTRINQLEFTTSSGNPLVVKVGVTFGSNPDEVDSYLFAGQPMLVSSGGRLDIPVEPEITNVRSIKIIFYNQGSQTVKVFGCVEKGTTRAPSTTKVPSTTFAPPSTTRAPSTTVAPPSTTRAPSTTLAPSTTRAPSTTVAPPSTTRAPSTTFPPLSTTRVPSTTFAPLSTTRAPSTTVTPPSTTLAPTTSVASTTQEYCDPLCVCQVDCNGVLIRPNCPGSVPSYCITCKTCPPGTTESPTGVYCESRPDPEECVTTTSETTTAGYCIDPMSPFGLDLEKDNSRETRPPRDPDVSTYIGQDIPWLPGVPDAKVTVLFKQQVHIRAVRLQGAEYQDGTYNLQTIFVHHLPSTGVIQETVHTFTITLNGVTPRDYFFPREMSYVVNVTLIVMSTSKFNSTLRLDFLGCTEVLPSTTPVVTTPSPPTTEAPTAATTTLKPSTTEEVTTTVRTTTPEGTTKEITTVETTTEEGTTTVVTTKQTTPKTSTTEASTITAESTTVTVKTTAPEITTTKMTTTAVSTTEASTTAAPSTTEALTTRLITTETPSTTEQPTTTIRETTTVVSTTPQFTTREQTTVASTIETTTTGETTVVTTARETTKIPSTTQVSTTEKVTSTAVISTTPELTTTEQTTTSVSTTEASTTEVPSTTERTTTRESTTVRPTTTSLPSTSEKLSTTVIYTTPEATTEETTTVVSTTVTTISPPSTTPEECTEDLDTYQPVTVTRQESDSDSILTPGDWWRPTNPPDDVNSPYSGSYLEATFSPRVEITSVIIRIEQGPPGDITVAFRVQPGDRLPYVPLVGDDSSTIFTGQTDSKIPMPSSMPLVTGIRVSIITSNPDGYKVIFNGCEHEATTTEAPSTTKAPSTTELTTKVSTTLKTTTPSTTAAPSTTEKVSTTVTSTVTPTATTTKETTVATTSQETPTAPPSTTEKTTTRVSTTEAPSTTEQPPTTVQPSTTKEVTTVISTTPESTTKETTTLYSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXJ1</accession>
    <name>A0A8B7ZXJ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein AF-9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110989881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022110263.1">
        <property type="nucleotide sequence ID" value="XM_022254571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXJ1"/>
    <dbReference type="GeneID" id="110989881"/>
    <dbReference type="KEGG" id="aplc:110989881"/>
    <dbReference type="OMA" id="MASSXCK"/>
    <dbReference type="OrthoDB" id="10053467at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16906">
        <property type="entry name" value="YEATS_AF-9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1970:FF:000003">
        <property type="entry name" value="MLLT1, super elongation complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040930">
        <property type="entry name" value="AF-9_AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052790">
        <property type="entry name" value="YEATS_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827:SF3">
        <property type="entry name" value="AF-9 ANC1 HOMOLOGY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47827">
        <property type="entry name" value="AHD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17793">
        <property type="entry name" value="AHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022110263.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="73434" checksum="98C5625BC795A6CD" modified="2022-01-19" version="1">MTTQSVQVKLELGHRANIREKPTPQGFTHDWLVFVRGPEGSNIQHFVDKVVFQLHESFPKPRRVVKEPPYEVAESGYAGFLMTIEVHFRSKEEPKKVILNYDLFLNTEQQPPVNHIRCEKLTFHNPTEDFRRKLLKAGGIGVLPTDPGIPTSPTASPTFPVPEGGIGGKPLPPSFTDSSLYAKGKPQAAASSLQVNKKYKAQASKDSSKTSSKPMKDHKEVKTASKEPKTSSKEPKIGSKEPKSNFKEPKPGSKEPKSSSVKDSKVSSKDNKTPVKDAKPVSKEPKSGSKEPKTSPKPPPKDPTKTKPSVKRPASTSPAPPPTSQDSAKKRKRKDSSDRGPHEKSSSGKPSPAEKGPSGDKVKPKEKASKPKTVKPAAVSQGSAGLFTPEICVSRKPKTALPEPPKELPPFEDELSTGEGGEAHSPSSSISFSSLPRGGGGVLNTLMAELGDENDDDDDDDQDIGLPYRKTPSPVTTLPPLSNHSTSSNEQDYGRIPSGTPATSDKTKSGTKSGSSKKNSMSNGSKKNGYSNKGERKQKSGEIKHKSVDAKQKTQDAKPKSSDGKQRSSENKAKLADTKQKYVDKKSSDSKPAKASEGKPRQAEAKLSKGNQGYLNDLVLLHQKLSCLQNREQLQKVVDLIEETGLFHITDATFDFDLCSLDQTTLRKLQECVSSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0K4</accession>
    <name>A0A8B8A0K4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110990041</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110515.1">
        <property type="nucleotide sequence ID" value="XM_022254823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0K4"/>
    <dbReference type="SMR" id="A0A8B8A0K4"/>
    <dbReference type="GeneID" id="110990041"/>
    <dbReference type="KEGG" id="aplc:110990041"/>
    <dbReference type="OMA" id="FMISGEM"/>
    <dbReference type="OrthoDB" id="9929128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022110515.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15402" checksum="CFD9518EA50A0F2A" modified="2022-01-19" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTELRFQSSAVMALQEASEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A101</accession>
    <name>A0A8B8A101_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-related protein Rap-1b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110990592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111359.1">
        <property type="nucleotide sequence ID" value="XM_022255667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A101"/>
    <dbReference type="GeneID" id="110990592"/>
    <dbReference type="KEGG" id="aplc:110990592"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF7">
        <property type="entry name" value="GTP-BINDING PROTEIN DI-RAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022111359.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24087" checksum="7344D40C81D86F94" modified="2022-01-19" version="1">MLTLGTKASHVCRKDFFVSKNDHPNVFVHVLRKPLPKTADSNVSNVLALFISQKKYTICRGGVNSLPLAGNTTKMKGQAKDSAPRRLVIMGSSGVGKTALISMFLRGRVSPIYYPTVENCFAWKMSKGGSECQLEIIDTSGSGDFPAMHKLYISTGQIFILLHSLEDPKSFDEMLRILEEISQERPDEQIPIFVVGNKADLVSVLPPESLSVRCLKGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1F1</accession>
    <name>A0A8B8A1F1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110990686</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110990686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111499.1">
        <property type="nucleotide sequence ID" value="XM_022255807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1F1"/>
    <dbReference type="GeneID" id="110990686"/>
    <dbReference type="KEGG" id="aplc:110990686"/>
    <dbReference type="OMA" id="ITCPERS"/>
    <dbReference type="OrthoDB" id="6365500at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="284"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022111499.1"/>
        </source>
    </evidence>
    <sequence length="559" mass="61530" checksum="213401B4CAB6841A" modified="2022-01-19" version="1">MFRFASGYASEKFRSLSAYRLASPQPVAAVRHDAIAQALKCPSVKITEKVVRPLKLTGHSPVLSGQSPAITCPERSGQGDQQPEGRDVGCDIAQPTKGRNNLSSTDETFPRSLTVPQEDRDPEPPGKMKEAGEGSAGETTPLPDNKTAQPLPDLLNMTPCEMLKMSRSEKTAVANGVTDHIQRAVRANISLTQEEQGPHVEENKQNAEKAQQLFDQMQTPITAGPGSSQRNNPVNQTEMIHKPCLSTRGNKQPQTSPTQLGSLGTLPRIDKADLTPVMSRKGHSYSTVKLGSGSFGEVSLMQNCTDGTLIAVKRLTKVGNRLKAEEAFKRETQAMNAVSSSSAFPKFLGIVDRYSFAMEFLGDLDKQNACSAYKMFRKRSSKMKSLDWLKVATDVTQGLQDMHAAGWTHNDLHSDNVMVWRDPEDQSGGWEGKIIDLGYAYRIDNPPPPQQLTPTQEKKCFKDCGQLAPEVIKGTSRYNVKSDVYSLGQFFLDIVSETGRASCLKALGKRCINKDPNLRPTLDAVLQELALMHYERLNRPQKTGPLAGLFRSLKNRFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A276</accession>
    <name>A0A8B8A276_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110991024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022111789.1">
        <property type="nucleotide sequence ID" value="XM_022256097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A276"/>
    <dbReference type="GeneID" id="110991024"/>
    <dbReference type="KEGG" id="aplc:110991024"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035497">
        <property type="term" value="F:cAMP response element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14689">
        <property type="entry name" value="bZIP_CREB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000054">
        <property type="entry name" value="Cyclic AMP-responsive element-binding protein 3-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46004">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46004:SF3">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="353"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="367"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022111789.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="70505" checksum="8F027507CB0616E1" modified="2022-01-19" version="1">MPGCACPYAQHCKICKPGRWTHDKYTAAGSQNPTRFTPISDRTGQRPRHSIAMDDLLGGNSLYDGEESDFKYILDSDVFHNVPLSEQLEGVQSDTWFNTLFDDPMLCDRDFGAPSPTPHIQAEHSYSLSSLSEPDSPVSSGLTEDELDTFDLPLVDPETNLPLIIKSEPLDDPTEAHFVLKEDLPRVIFPTPKMEGSNPHGPKPVQNIKPKQGTIKIKVEPMMLDMRTDNGGIVFQRKLDIVLKDLSPLAMATGLDGLCLPPTPPSSTTSDSEGGNSPSRQTSEPGSPRPLPTIVKKQDLHSRMISTQPLFTNTQRLPQSGPLILTEEEKRTLIQEGYPIPTKLPLTKSEEKSLKKVRRKIKNKISAQESRRKKKEYVEALERKMETFTQENSDLKRKLQSMESTNRTLAAQLQKLQSIVNKVAKPLKANSTQSSTCLMVLVLCFAVFLGGWSPQSLFGNSNLPKMPSTPGPQYGPFPSSYYASMHYHDNLKKEAKTAGQSGIPYGPEQHYGPYYGPYISPSVRSSRMLFSNDDSELDQKPPPNYPYMERMNPLDHGLATSASDSALRNRKLMVPRQHPETNTMATTGSFLGSQGSGVNPAEAEGLVGLQAVMHPDIEAQLVAMDSVTRLTNNSKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A347</accession>
    <name>A0A8B8A347_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Cyclin-dependent kinase-like 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110990609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111375.1">
        <property type="nucleotide sequence ID" value="XM_022255683.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111376.1">
        <property type="nucleotide sequence ID" value="XM_022255684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A347"/>
    <dbReference type="GeneID" id="110990609"/>
    <dbReference type="KEGG" id="aplc:110990609"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF111">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022111375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022111376.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20120" checksum="9E0ABCC60C61AC4D" modified="2022-01-19" version="1">MNKYEVLGIVGEGAYGVVLKCRHKESGQIVAVKKFKDSEVSYSVLQICGCQWSHLPVLFHSAKLILTDNEGVRRTTLRELKVLRQLKQENIVELREAFRRRGKLYLVFEYVERKFGKSHKTFAQPSHDVCMTNLRWFGTLANSEMVWHLLLDTCEGFVHRHDGHSFAASNIWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A419</accession>
    <name>A0A8B8A419_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein LOC110990896</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111670.1">
        <property type="nucleotide sequence ID" value="XM_022255978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990896"/>
    <dbReference type="KEGG" id="aplc:110990896"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF144">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION-TYPE BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111670.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39828" checksum="813D952B9685114E" modified="2022-01-19" version="1">MADTDDVIVLNVGGTLYTTIRSTLTRYPDSMLASVFSEGFTPLRDANGALVIDGDGPMFRHVLNFLRRSKLNLPEDFKDWDLLASEADFYKIPVLKDAVLKAQASKVGPKMEFIEFIEGANGPNSFKYRGSLEIFKKFPQYLLKNNFDVIREGDRIIQRHVDEIDYFLENRGEVNGYFGRFEGLEYSEPVKLSNLSHIPLPKLSKRDPPNWMKIFQHATGLGFELLSTSVSNATKSWLFARKLCLLVMAGIVNLNVGGCLYTTNLWTLIRYPDSMLGAVFGGKLDPSERDANGAXVIDGDGPVFRHVLNFLRRSRLILPEDLSDWDLLESEADFYQIQDLAAAVSSLQKERAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A5J0</accession>
    <name>A0A8B8A5J0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein LOC110991222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110991222</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112185.1">
        <property type="nucleotide sequence ID" value="XM_022256493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A5J0"/>
    <dbReference type="GeneID" id="110991222"/>
    <dbReference type="KEGG" id="aplc:110991222"/>
    <dbReference type="OMA" id="VKHIGRR"/>
    <dbReference type="OrthoDB" id="10048772at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF330">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="805"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="759"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="230"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="676"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="588"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022112185.1"/>
        </source>
    </evidence>
    <sequence length="849" mass="95486" checksum="54834C5A0481B0ED" modified="2022-01-19" version="1">MDGIPMDNLSSNPAGVVTQSPAPAPTILELDEAPLVDVPSTPKRTGLKVQCVYYMRVFLQFMCSYVGLTAILAGYLVFGAFVFQAIEAPVETRMRKEMHADKKFFFMKMYDAVSGMKRENWTQQALQELNLLQKDFIHFYNYDLEVDGEHVQKWSFVGSMLFSLTVISTIGYGHIAPVTIPGQIFCILYAMGGIPLMLLVLTNVGRVLANVARLLYIMYTSRLCQRVRMRCRQRRSRKRARKMARRRAMARKDSSRSTRSNRNRSNKGKKSRPVKKTPSQATIRVDTEPYREGRPMSVNMELIRSEPPLPPSYAESNEMEDKISDTRENAEMFSEEANKPNMSEAPGPVHFSISPTESLPEVFPLGAPLKQPIAGKAPKADMDDDFDDLSDLDEPEPEEEPTKQNDKQSMEFGTKPAQNNKSDCKGSISSTPLLQPLQREATCTNKGPASSEVDCAITIEESGDHHEEKRLGRASSSIALGELCEKRLPPRQFSCIELRQIEERRSISFNMEGIAEEEDNSPKENDVFLSKESQSVDDLNAEVIGSASDLNKRKNSRGKGKTKKKTKSKLKKDGEKTSKSRSSKHRKNAELRVVERRKGTPKKLRTKRPVMSPPTLRSLHSKQLKILDKATAVRLATYDKDFGNSREDLTTLIPALKHEKVRLLCEYDRGVIRDRVHNPRGQRRRRMAASESGSTRSRSSRGARRRRRKGRESGSTTPVGSDRTSTFDSDTESTDTDDPGADPLQQAEIPIGPVLAFFFSYVALGAVTFFFIMDKWNLFQSFYFCFITLTTIGFGDYVPDDKLSSLLACCLYTLVGMAVTSMCIALIMKKFVVTVKHIGRRVGIVGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A5R4</accession>
    <name>A0A8B8A5R4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-glucuronosyltransferase 2B28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111301.1">
        <property type="nucleotide sequence ID" value="XM_022255609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A5R4"/>
    <dbReference type="GeneID" id="110990559"/>
    <dbReference type="KEGG" id="aplc:110990559"/>
    <dbReference type="OMA" id="LAGQCEP"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034389073" evidence="2">
        <location>
            <begin position="26"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111301.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23619" checksum="F73489DAD07077E1" modified="2022-01-19" version="1">MSRTILAVLAFGFCFFAILPALSSAEANSVKKKYKFLLFGSITGGSHYLCLAKLGRALVRHGHGVVSLISTCNPSTLWENDVGLFPHVVFNSSYTKQDKADILFSLSSKSMKGFSANSEELSRVVRVALFRECDALFNDSATMKRLHEERFDMLIADDCIPCSPLLAQALDIPFVLNSVFFAIPTKHGQCEGTWGAPGICGGMFPPLPPGYTTVSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A6A9</accession>
    <name>A0A8B8A6A9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990727</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111516.1">
        <property type="nucleotide sequence ID" value="XM_022255824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A6A9"/>
    <dbReference type="GeneID" id="110990727"/>
    <dbReference type="KEGG" id="aplc:110990727"/>
    <dbReference type="OMA" id="MEYREFY"/>
    <dbReference type="OrthoDB" id="5959603at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034596128" evidence="1">
        <location>
            <begin position="21"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111516.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35324" checksum="F365C3214E0C24DC" modified="2022-01-19" version="1">MNTLIVFASCCLLLSLQAAGSPFGYDEIHSMSKKYTEKSEPETAWAIPVSDSSAPPPINVSVVTNYITTEVQTLAQEAEITFIGQLCEQSKGFEVEVTVLLNNNPDWDPSVGVLYYYVVDDPNKGSSAALCNNSPGGTPQANCTVKAWPSNGDIYIKGHAGQSEAVSFTLSVTMKQKAGIKPTPFFFDKSPFRNLERTPSANNPTVYLSQVVTLSSIQPLGYHKSALLAFTFCPTPQTGTRYEVQSATSATDGHSSYASYICDKLPCVVDGENVIAANGRQLPSNIVQTESGTWKTLYALIVGWGGVWNPPKDEYIGHFIFDAQTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XG84</accession>
    <name>A0A8B7XG84_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ankyrin-2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110973034</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022079137.1">
        <property type="nucleotide sequence ID" value="XM_022223445.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973034"/>
    <dbReference type="KEGG" id="aplc:110973034"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.30:FF:000009">
        <property type="entry name" value="Ankyrin 2, isoform G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000003">
        <property type="entry name" value="Ankyrin, isoform B"/>
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XH20</accession>
    <name>A0A8B7XH20_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bombyxin C-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079235.1">
        <property type="nucleotide sequence ID" value="XM_022223543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XH20"/>
    <dbReference type="GeneID" id="110973074"/>
    <dbReference type="KEGG" id="aplc:110973074"/>
    <dbReference type="OMA" id="CSDVYST"/>
    <dbReference type="OrthoDB" id="6330326at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Insulin-like" evidence="1">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022079235.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="15190" checksum="2186968D53C7D3B2" modified="2022-01-19" version="1">MTHSLRGTLRLPLPQARQVTVMSLVALACFVYVSADSWYCSDVYSTVQSLCDSCYAGFDKRTNSITRPIEEPFVERKNAVDFFKRGTARGTRRGIVDECCHRQCAVSEMMLYCCEQKQREYYTFVGWLKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIC5</accession>
    <name>A0A8B7XIC5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110973768</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110973768</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080546.1">
        <property type="nucleotide sequence ID" value="XM_022224854.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080547.1">
        <property type="nucleotide sequence ID" value="XM_022224855.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080548.1">
        <property type="nucleotide sequence ID" value="XM_022224856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIC5"/>
    <dbReference type="GeneID" id="110973768"/>
    <dbReference type="KEGG" id="aplc:110973768"/>
    <dbReference type="OMA" id="NPPKCCK"/>
    <dbReference type="OrthoDB" id="10012689at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00934">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080548.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31186" checksum="B4C213F7F85A17E6" modified="2022-01-19" version="1">MAAFGDPLDTSDECTRLRTGYLDQLNLDNGKVRKRWVIFQGNQQSGLFQLKIYKNDKEKILKSSYTLTKETLVGTERGALQKPKKKREKSAYWAVILVTDTVVFQEPAPWEQGGIGMELRSWDTVVKSYFSNESWVVKTLKGFVAPEFQMTLHVTRHALSLVTMNPPKCCKRWELSRISDYWSREGIFYFKVDVASSAEEDFEMKAESESHARRIRLSLDRVLTPGGLQPLDLSTDRPPLPSDRAPSPERYTPSPTLQKKLPTIAPPALSGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIP5</accession>
    <name>A0A8B7XIP5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973509</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080076.1">
        <property type="nucleotide sequence ID" value="XM_022224384.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973509"/>
    <dbReference type="KEGG" id="aplc:110973509"/>
    <dbReference type="OMA" id="GHENSCH"/>
    <dbReference type="OrthoDB" id="6430699at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1121"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080076.1"/>
        </source>
    </evidence>
    <sequence length="1308" mass="142834" checksum="8CA72EB2CC52C676" modified="2022-01-19" version="1">MPTSGEARIRPTSTYNLRSRPLPRAKKATAGVRTTSRSLSKNKENVKQPGGKDKQSRIPVPVKTTPAAKATTPADSKASPACRSKRRVRPVPDFAKLHKSWQSSFNKGKACSKKQCTQIREFDLTKPGTVFHARYHDGKHVSPTMDEWDEDIFQSDDEALQSILNAGLPASESQQQGRLTVAGYGGSGFTQAKPGRQTLGALPSTFQGRADNTQNIKTTGSRQVEGQASKPALQNDPLEQEQHKGRNPSLAEQQQGMDINFEPDAGALASILNNTGTNFQRQAPAVRQTIGTATGAGRNHESMYCGRQSQGPMRTSIYYQRPRNMNFNRVYTDFANHILSRLSLAENMVPSSNSQPLERLTNTKTTVVARSTCKAVNKSHVMMSAPRRMRTPATASRILNPRHHAALRGQDTSCSPALVAPPSALKKPNANKESRALSVKWADILSPPGIRTASVPGKDEVATALFVDEDTRSLDLFSVNQPTNNEGQQQGANIKGKQDQILQLQQQVAVHCQELKEMDEIEQQLLSEIQRLQQDDCLLSPPTADPEERKEQEARHDRAVDSPPLPVVPLQCDQQSLPGKALLQSSSQPQQKQFFQMPEQDSAPTLGVSTAPGKATESLQKPSTNHTDQFGKKPFNHSPGSPFKRSQLPRNVTYMYGLSQPSATPMKFHSESNCKMSNESTSCDASELWHQSLHRPLETLNTPEKPFVEMAECDSPSKPENRSRTPDLRMPEIKMETPQEMLNKNMAAERVEFNHHGCSDDVNPQRTKTSLSQAATTMSSGHLGQNASDGLHTSRRPLGAASRPQLATETDISTASHFIPSGTGEPINSFSQKLSIEHPCSRQESLPNRMWNSQKLIVPSGSSHDLTNGYPQPDSFCRIATSSSFHSVPTNNHESPVLAVNQASMGLHEHSCQPNTDRSGNSKMPQGSVFSSSTTSLLSSGQPLLPNAREWNPQLAGERVSAQMSSTPAHICTPQAVKPHSMIKELTLKQLLPSVSVLGNQPALYSQDIPPIHTPLAMRSMSALSRNPDLEVSPVQFVSPIPMRPGQVPPSAEGKPTSFSPAQHQTALTSDLPSVSLTATVSETEARNSNPLQQESGLDYYPASATRATRETSNFEAVAADDNLSQQYSSRTGNPTSAPTSTQTKATSMPLKEINLHNTLHVIDQVLEATTVGDAGNEKPKPYSHGEPQRPWSHLKFKGQGSLSLGAELMTNRGAAAFLKSKMKPLLSATTNQLFHEALLDEECALYACRLPSKFNPRNAPDRLCLDPVAKILMDGDDMHFVPIHSRGQVYFSSPIGSAFNTYISSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKM4</accession>
    <name>A0A8B7XKM4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptor moody-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110974207</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022081358.1">
        <property type="nucleotide sequence ID" value="XM_022225666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKM4"/>
    <dbReference type="GeneID" id="110974207"/>
    <dbReference type="KEGG" id="aplc:110974207"/>
    <dbReference type="OMA" id="VIRCIML"/>
    <dbReference type="OrthoDB" id="5967390at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="40"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022081358.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="44252" checksum="AC222716E2F4FB29" modified="2022-01-19" version="1">MSNYTQTVGVVSTTSVYTSYIERQFLAAIYGLISFAGVLGNCAVLLAVVLSRRPRTVTNVFVVNLAVADLITCLSMPISILAALSESREELLVSRNLCAFQGFVLIVCIGCSLNNIAAIAVYRALITRRQNSSRLRALFSRRGLAVMVSTSWLIPFAVGLLPIVSEFGSYEYDFKLSTCTFNPTANGSSTFSKIMVALYYPVQLLTTFASYAVILYTVRRHRRRITAATERRVAVVGSATMKLPPSPNTPGPSHKPAWQGLSANDRLRVAPAHGPLRQRSRPGSFPAIRPSSRAAVGPPAQGRRHIHRQIKVNLSLFLVVFFFLLCFTPYSVLMALLRNKSLKVFPFLGALVTFNSCVNPVIYAARHPDFKTVIRSILLCRPSQIPMKSSFLQSLLSLRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XL83</accession>
    <name>A0A8B7XL83_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Sal-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15 16 17 18 19" type="primary">LOC110973937</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080880.1">
        <property type="nucleotide sequence ID" value="XM_022225188.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080881.1">
        <property type="nucleotide sequence ID" value="XM_022225189.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080882.1">
        <property type="nucleotide sequence ID" value="XM_022225190.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080883.1">
        <property type="nucleotide sequence ID" value="XM_022225191.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080884.1">
        <property type="nucleotide sequence ID" value="XM_022225192.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080885.1">
        <property type="nucleotide sequence ID" value="XM_022225193.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080886.1">
        <property type="nucleotide sequence ID" value="XM_022225194.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080887.1">
        <property type="nucleotide sequence ID" value="XM_022225195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XL83"/>
    <dbReference type="GeneID" id="110973937"/>
    <dbReference type="KEGG" id="aplc:110973937"/>
    <dbReference type="OMA" id="CHITRSQ"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF55">
        <property type="entry name" value="ZINC FINGER PROTEIN PEGASUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022080880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022080881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022080882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022080883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022080884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022080885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022080886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022080887.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="85051" checksum="FB9B72715718D762" modified="2022-01-19" version="1">MDEATEAEVVSDSLPGSEEGDLDIDLELSNRLEDTIKQERVEEEEVDEEGEEEDRLEAAASQESQGSPTEKSGAKAAEAPAATAAGAAAGGQKSLTGYQCRLCTVLLSSQGALDEHMNIHSGSRPYKCRECNFSCSLQNTLVQHLAVHSHPRADMNSQLWLEQPQQQPAQPAVYNNHHHQADRQAPELHPPVPLPPRMPLPENHAPSLPFSTAVEQALMPSGLPSFPDQGKVFQCKLCTHVSPTKTHLNEHMNVHTGKKPYKCLVCGFSSAFRSSLMRHLIVHTGTSKQFKCDSCHYQTPYKCNLQAHKRKRHNSNSLDSLDMNYPPVTSQNQTPLEDSPPLQTHGKLFSSEEQARYLMQSELTNSAHPTHQSHENSGNRRHSLSPDDHDSSASNDTHESARITNSHVPLLKSGDASRYNSDGSVVPQSPEPPVLEKNSLVSNAEMTDRPKSGEALDFSSPSMSNNVHDLITNASTTQSAISMLSNSVSSASSALGLPSGASFTSSVPNSMATSIPSTSPQHPLTEISVITPLQWAGAGFPIYRRKKEGGARKRKRTPLPKRNYLISPNGDDLNNSWTDTRPEIADYVRAGGEPQARQYCQVTQAYSFKTEEGLPYAIKSGGINGVDLSVGPREVVYPDIEPVSNSSVSPVSQAADDTPDERNTLPQGLPVMMDAHPENLAFNQSSQATQTNLPYVVGDSSGKLDGQAQTDQVGPDPSSLPSNLLKCPHCETFFTDHVIFTLHMSCHGSRHPFQCSICGYVCRDKIEFTCHITRSQHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLC5</accession>
    <name>A0A8B7XLC5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fibroblast growth factor receptor-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19 20 21" type="primary">LOC110973874</name>
    </gene>
    <organism evidence="17 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Has a negative effect on cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080757.1">
        <property type="nucleotide sequence ID" value="XM_022225065.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080758.1">
        <property type="nucleotide sequence ID" value="XM_022225066.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080759.1">
        <property type="nucleotide sequence ID" value="XM_022225067.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080760.1">
        <property type="nucleotide sequence ID" value="XM_022225068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLC5"/>
    <dbReference type="GeneID" id="110973874"/>
    <dbReference type="KEGG" id="aplc:110973874"/>
    <dbReference type="CTD" id="53834"/>
    <dbReference type="OMA" id="IVWWKDD"/>
    <dbReference type="OrthoDB" id="6244905at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005007">
        <property type="term" value="F:fibroblast growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000016">
        <property type="entry name" value="Fibroblast growth factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000246">
        <property type="entry name" value="Fibroblast growth factor receptor like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000593">
        <property type="entry name" value="Fibroblast growth factor receptor-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052615">
        <property type="entry name" value="FGFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19890">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19890:SF10">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR RECEPTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0732">Signal</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665449" description="Fibroblast growth factor receptor-like 1" evidence="15">
        <location>
            <begin position="25"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
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    <feature type="domain" description="Ig-like" evidence="16">
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            <begin position="147"/>
            <end position="236"/>
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    <feature type="domain" description="Ig-like" evidence="16">
        <location>
            <begin position="245"/>
            <end position="354"/>
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            <begin position="124"/>
            <end position="157"/>
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        <location>
            <begin position="447"/>
            <end position="478"/>
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            <begin position="124"/>
            <end position="134"/>
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            <begin position="136"/>
            <end position="148"/>
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            <begin position="451"/>
            <end position="469"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00053149"/>
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            <dbReference type="ARBA" id="ARBA00074412"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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            <dbReference type="RefSeq" id="XP_022080758.1"/>
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            <dbReference type="RefSeq" id="XP_022080759.1"/>
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            <dbReference type="RefSeq" id="XP_022080760.1"/>
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    </evidence>
    <sequence length="530" mass="58042" checksum="47FB2CF84570C580" modified="2022-01-19" version="1">MGRSWAALMPGLLLVCLAVDNVLADVQGPPRLDQPIVGFQKARVGSKIKLLCPVVGNPPPLMMWKKDGESINTLWERFKVLSAGLKIKNVEMADAGQYICRATNGFGSVSLNYTLTVVEDRRNLGRVKNSERPEAPTGSKPPTGTKPKFSQPSKMRKKKFVCPLNSSVKLKCAATGYPKPQVLWMRNGVTLTEEELEEQRASFTLKLKSLKASDSGDYTCVVFNRNGQINATYSVEVVDQAHAKPVLQGEHPVNTTVAYGGTTSFQCRVRSDSPPHIQWLKRVEPHNGNQRINATIDMDGQKFVVLPAGEVWSRPDGSYLNKLMISHATEEDSGMYICLGANTNGYSVKSAFLEVLPDPNGRSQPGGRNNNFNVNINMNDVVAKQNPQDIDTTKKVLLITIPLAFAVLFCLGAAVCTYHRNKNIQGYASPATNQPSNHLAVRAEHKRNTPVHPNQSDCEQSVPLTSPPSSLGGVHSYHPPSREGVAINRYTDLGMSAESYSDTLNSSGSVSSGKVHTHQHVHQHHVVHHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLG1</accession>
    <name>A0A8B7XLG1_ACAPL</name>
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        <submittedName>
            <fullName evidence="6">Phosducin-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="primary">LOC110973986</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Echinodermata</taxon>
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            <taxon>Asteroidea</taxon>
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            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080951.1">
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        <property type="component" value="Unplaced"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Glutaredoxin"/>
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    </dbReference>
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        <property type="entry name" value="Phosducin, domain 2"/>
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        <property type="entry name" value="Phosducin-like_reg"/>
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    </dbReference>
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        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02114">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="4">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
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            <begin position="118"/>
            <end position="261"/>
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            <begin position="1"/>
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            <begin position="1"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="Pfam" id="PF02114"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_022080951.1"/>
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    </evidence>
    <sequence length="263" mass="29563" checksum="2160D39C0895EDCB" modified="2022-01-19" version="1">MADRFDDRILGEKDQYYYSSDEEDTDDGNGSGDEGAKTVRGPAEDPSEMEEFKGGAATHTGPKGVIEDWRRFKQLETEKKQEQEAERMALAKHLAMTCRSYYSQVGKELWLVYMPTLCVRPVFGKVINLTKQNFVEAIDKENKNVSVVIHIGDPAVLACEAMDGCLHCLAQEYPHVKFCSVYAADVNLSQNFIQNGLPALQIYKSGTLIGNFVRLSDQLGEDFYAGDLETFLQEHSHLPSKEEQLLVRGPHQEDSDDSDLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNT4</accession>
    <name>A0A8B7XNT4_ACAPL</name>
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        <submittedName>
            <fullName evidence="11">Nuclear factor erythroid 2-related factor 1-like isoform X1</fullName>
        </submittedName>
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        <name evidence="11" type="primary">LOC110974378</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081665.1">
        <property type="nucleotide sequence ID" value="XM_022225973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNT4"/>
    <dbReference type="GeneID" id="110974378"/>
    <dbReference type="KEGG" id="aplc:110974378"/>
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    <dbReference type="OMA" id="KPWRDPF"/>
    <dbReference type="OrthoDB" id="7458135at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14698">
        <property type="entry name" value="bZIP_CNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF55">
        <property type="entry name" value="SEGMENTATION PROTEIN CAP'N'COLLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034221690" evidence="8">
        <location>
            <begin position="26"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="647"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="285"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="482"/>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="737"/>
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        </location>
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            <begin position="672"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="575"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022081665.1"/>
        </source>
    </evidence>
    <sequence length="759" mass="84488" checksum="4F0D11EB6D39450E" modified="2022-01-19" version="1">MHRKKPWRDPFLTLAVILSLLRVDWDDYMQRQLGSQLPEIHEILLGQSAALTETQFHNLYNSLDGSYVNFKNLDYDLHSQSAFRELNSLSHGLYPVSRDFREVSTWLLDRLEPNNVRSLPLVNVASAPNNNNNNDENNNNGEASEGEANGPAQNTLDGAVAVTHSGQNIVDLSPEDMDLIEALWRQDIDMGICREESYAFKEDLLVEKGEHADKLKPQQQSWDHFGYNIDGETGEYVPNPPGLEVVQPQTPQPTLPQVPVQPDGNISLEDCLQLLEDEYLPAVPQTDAEQHQAQQQQQPLSPQEQEQRWEDLASIPELTRQLHELPGLPYQAAVDMNITQPHTTQDAFAINATTNGNVNLQNATLAANRNVLPVELQRLYEFVQPPEVFSPLSNFANLSLSSTSPTGSINGQQNLNFSSFLLPDQTFSPTLETPMPNATDNQDNSSLLMELLNTSSVGEVDPMDVDFDEQIQNVMQAFGETNSTSSFEGSCSGFEDMSDGSSPYHTSDDGLEGATGYNASLDGNGLNGTSSGYGYHRQRGGSSCGGDSDSGSSFSSYNSQSSKPENVKHNHTYASSSSSPTSTRSSNSSKSSSTKKDKQNVVKLSRDEKRARSLKVPVPIDKIINLPVDAFNDMLKKYELNDAQLTLIRDIRRRGKNKVAAQNCRKRKINALVSVEVNIDSLKVEKEQLQLEREQIDKETSDMQARYEQLYSEVFQSMCDEHGDPVDPNEFTLQQMPDGSMFLVPRNSTDLDKDKNTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XS29</accession>
    <name>A0A8B7XS29_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">15-oxoprostaglandin 13-reductase</fullName>
            <ecNumber evidence="2">1.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110975453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022083659.1">
        <property type="nucleotide sequence ID" value="XM_022227967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XS29"/>
    <dbReference type="GeneID" id="110975453"/>
    <dbReference type="KEGG" id="aplc:110975453"/>
    <dbReference type="OMA" id="NFADTHQ"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08250">
        <property type="entry name" value="Mgc45594_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF3">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083659.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="36780" checksum="3CBA7D93C7C8314F" modified="2022-01-19" version="1">MALPATFRKLVATKLSQHFKDAVTLQTVPMLKPGPKDILVRNRFVGINASDINKTAGRYSLHDKPPFEIGFESVGEVVDFGSEVKNVKIGQGVCFMHNGAFSEYQVLPAKMASPIPSIQPEYTALLISGMTADISLREVGRIKRGETVLVTAAAGGTGQFAVQFAKQAGCHVIGTCSSDAKAEFLKSLGCDRPINYKSENLADVLKKEYPAGVDVVYECVGGDIFHTCLRSLAPKGRLITIGFISGYKEDAVAAPTIHPKEMLGLLSKSASINGFLMHSYTDQWLASFVRQADLLAKGSLKVGVDLGKNSDKGPFKGVEGVMDAIDYLYSGKNKGKVVVEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUD9</accession>
    <name>A0A8B7XUD9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytoplasmic FMR1-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CYFIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084463.1">
        <property type="nucleotide sequence ID" value="XM_022228771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUD9"/>
    <dbReference type="GeneID" id="110975902"/>
    <dbReference type="KEGG" id="aplc:110975902"/>
    <dbReference type="OMA" id="DQPNRVE"/>
    <dbReference type="OrthoDB" id="10265867at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008153">
        <property type="entry name" value="FMR1_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01698">
        <property type="entry name" value="CYTOFMRPINTP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="3">
        <location>
            <begin position="83"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084463.1"/>
        </source>
    </evidence>
    <sequence length="1276" mass="146632" checksum="AE26EBACCB78D298" modified="2022-01-19" version="1">MDLPEANAVPQPQPSNPLQAGKMAATVTLEDALSNVDLLEELPLPDQQPCIEATAVSITYQANFDTNFEDRTAYVTGMSKYIEEATVHSELNKLLEEGESYAVNLYTWRSCSRAMPAIKSNDQSNRVEIYQKFVEVIEPEVTKLVNFMYFQQRAIDAFCRDVKRLCHSEKKNDFVSESYLLTLGRLINMFAVLDALKNIKASIRNDYAAYRRAAQFLRVMADPQALRESQEVVMFLANNDKITQTLKENLVKIDGYEELLMDIINLCVEMYETRHYVVPSEKHMLVKVMAFGLYLLDTKDMVNIYKLDQKKKICLSRIDKIFKQLEVVPLYGDIQIPVFSYIKKSPNYEAHKSVWSCDSGNTSQYNLLEHLVSIREDHTRYISQLARHSNKEVTTALKDTNRSEAENKALYSLALKGLCLLSKWTSLVTELFSWKLIHPADKRTNPKIPDTAEEYEKATRYNYSSSEKFALIEVIAMIKGLQVLMTRMESVFQEAILRTTYAEVQDFTQKTLRDALRTAVKKKKNLIKTIIRAVRETCCDWVNGLEPKDDPCLKGEKDPKGGYTIKVGRRTVGPSSTQLYMMRTMLESLIADKGGTGKKTLRKELDGPSLEAIDDFHKKTFFYKHLLNFSETLQQCCDLSQLWYREFFLEMTMGERIQFPIDMSMPWILTDHILETKDPAMMEYILYPLDLYSDSAQYALTRFKKQFLYDEIEAEVNLCFDQLVYKLSDQIFAHYKALAASIVLDKRFRTECETYGISIPYPPANRYETLLRQRHLQLLGRSIDLNRLITQRISTAMYKSLEMAIIRFESSDLTGIVELDCLLEVNRLTHSLLSKHMKLTSFGSMLREANHNVMAPYGRITLHVFWELCSDFIVSFCYNGSTERFVRTKLAFAQPQNRDKPPSSSPSYIYGTKLLNTAFATVNSLYSSFIGIPHCRCIARLLGYQGIAVVMEELLKVIKRSINDYILPYVNILMDVMPKTCRLPRFEYGTKGVVAYYSAHLQDIAQYADLKMNLFHNFQEVGNAIVFMKMMEQCLAVEEVCDLLHASPFQNIIPKPHVKQGEKLENKLKRLEMNYAPLQVVPVVEKMGTQEQIADAREGDLLTRERLCCGLTMFEIVLNRIKGFLTDPVLTGPDPPNGVMNIDECSEFHRLWSAFQFVYCLPLKENNFTPEESYGEGLNWAGCTLITLLGQQKRFEALDFCYHILRVQKVDGVDADINGIPIGRLVDRIRKYQILNNQIFSVLNKYLKANESESSPVEKIRCYQPPIHQSVIDGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUL2</accession>
    <name>A0A8B7XUL2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110975955</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084534.1">
        <property type="nucleotide sequence ID" value="XM_022228842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUL2"/>
    <dbReference type="GeneID" id="110975955"/>
    <dbReference type="KEGG" id="aplc:110975955"/>
    <dbReference type="OMA" id="EIMIRTH"/>
    <dbReference type="OrthoDB" id="6114770at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026715">
        <property type="entry name" value="SPATC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029384">
        <property type="entry name" value="Speriolin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22192">
        <property type="entry name" value="SPERIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22192:SF17">
        <property type="entry name" value="SPERIOLIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15059">
        <property type="entry name" value="Speriolin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Speriolin C-terminal" evidence="3">
        <location>
            <begin position="395"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084534.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="58903" checksum="2196B0809B691DC0" modified="2022-01-19" version="1">MAQDNLLGTPDAADTSSLRLADIGTPEAGMLPLRLSDIMTPEGDERTTGDDGTVTDSGHEASAPSTATGGWQVPAQDRLGIGSDTQRRLRHEVRDLSEENQLLRLKLNLLQTNSNLKQVALIGTVISWFGDKGLLDDDINAVYTLTSMMMPARAADEHVSPAFTERSNATAGGPRQSRRTDNGPMESPEKSVVQDPKFRSPESNAGYSLNDNTSEWPSQSLDASFNPPFSSSKKEMRYPVALQGDETLLAGGGTDKQRGKRGTSVIPAGSELQNGAEANVDSLDESTKRLDSRIQQMEDAVSAFAGRQAETKSYIARLRQNATKRFRVWKAIEASRNLAAADLSLDDDDEASNEELATLGEQSITPTPLTQYLSSRQAEETGNSNVVHGTPSRKILGEIAFQVERRILAFVFQRKEILYGYNLGNLEIMIRTHPDQGGRSVLHRRYELLMDVLRSYGWVRGRHARFIADVIARYGTLRDVESAKAEALKRGWSNPSELKRGVLCLCPVMEVLDMLVVLDCLLHMARNDGQPVFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUY0</accession>
    <name>A0A8B7XUY0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110976033</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110976033</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. NFIL3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084663.1">
        <property type="nucleotide sequence ID" value="XM_022228971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUY0"/>
    <dbReference type="GeneID" id="110976033"/>
    <dbReference type="KEGG" id="aplc:110976033"/>
    <dbReference type="OMA" id="VSMRANF"/>
    <dbReference type="OrthoDB" id="6022300at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14695">
        <property type="entry name" value="bZIP_HLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000025">
        <property type="entry name" value="nuclear factor interleukin-3-regulated protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040223">
        <property type="entry name" value="PAR_bZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988:SF55">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11988">
        <property type="entry name" value="THYROTROPH EMBRYONIC FACTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="265"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022084663.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38137" checksum="D3E04E2EA7D0FC53" modified="2022-01-19" version="1">MASPPPLLPMQVANSSLLGQALQAANDMGGLSALQLAVQQQQLQQQQQFLHAVQAAHAQNAGHKMMSPTPSNEQALTLNNQGASPPGDTDSRDEEKTALVNLMPPSSLASPVSIQQGDQADLHAMVPSSQMQTPISSQLLTTSTSSDNAYTMPATAAAAPLPSINMPAGMMAGTNHVSNLNMGLAPHLIQLNNPQASMPVPQMVIQPGGPAGQEMVSPEQMMVQGVANITNNNNIDMMSNMPTQCTSSSTKRRNSKRPVPDTEKDEKYFERRSRNNMAAKRSRDSRKRREDQVSMRANFLQKENDILRAQLATLRQEANSLKQLLTQQRPIMPAQMSMQMPTQLMPKNMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVC8</accession>
    <name>A0A8B7XVC8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat domain-containing protein 61-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084818.1">
        <property type="nucleotide sequence ID" value="XM_022229126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVC8"/>
    <dbReference type="GeneID" id="110976114"/>
    <dbReference type="KEGG" id="aplc:110976114"/>
    <dbReference type="OMA" id="LIAGHEH"/>
    <dbReference type="OrthoDB" id="1661883at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03587">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="391"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022084818.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53303" checksum="AEB9EC1C2F90BDC0" modified="2022-01-19" version="1">MESLLGMIWPSRRSSPSADWRGMTNAGRRNPTHQERVSSVGDLEKLAELQHYIVTGDLSAFKKSLGRLSSSADVLYPSRWVIRPTLALFNAQGRHSQRLPASVCLIHVAASRGRHDMLEALLSAGASPNVLDSNGESALHHAATNPGTFRALQFHSYADHSRLVARWTSGSHRCVELLCSVPGIDLNIPSRLDRATPLHRACEAGRHASVSVLLAHGADPNVLNAFGETPAAMALIAGHEHVFRLFLELGIIFGSLDAIPYILHTSVNAYTESPSQDKFNIIQEILRHNGDLNKQDQLGNTPLHYAAAGSLVDYHLISTLLARGSDADVKNKMGRTPLVEFFFSHQIHTNNTNIKSVVLLASYMTTTPVIPAGQCVADNVHSGMWSPLYRKITEIIRVMSRKAPSLRHLCRQALRRAVRPHRLGDPAVVHDLPLPKALRDEVASRVDPESYSGHLVDYLLEQREFSQLDFLNSVSRDIRQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVD7</accession>
    <name>A0A8B7XVD7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Tetratricopeptide repeat protein 21B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110976107</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTC21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084811.1">
        <property type="nucleotide sequence ID" value="XM_022229119.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084819.1">
        <property type="nucleotide sequence ID" value="XM_022229127.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976107"/>
    <dbReference type="KEGG" id="aplc:110976107"/>
    <dbReference type="CTD" id="79809"/>
    <dbReference type="OrthoDB" id="10259630at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000197">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000219">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000245">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056836">
        <property type="entry name" value="ARM_TT21_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056834">
        <property type="entry name" value="ARM_TT21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056833">
        <property type="entry name" value="ARM_TT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25058">
        <property type="entry name" value="ARM_TT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25068">
        <property type="entry name" value="ARM_TT21_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25063">
        <property type="entry name" value="ARM_TT21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25062">
        <property type="entry name" value="ARM_TT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat" evidence="7">
        <location>
            <begin position="12"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="6">
        <location>
            <begin position="273"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="726"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fourth ARM" evidence="10">
        <location>
            <begin position="762"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="888"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="956"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="9">
        <location>
            <begin position="957"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B C-terminal ARM" evidence="8">
        <location>
            <begin position="1107"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="1199"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022084811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022084819.1"/>
        </source>
    </evidence>
    <sequence length="1318" mass="149530" checksum="58C6BF60107A349F" modified="2022-01-19" version="1">MADTDATTLAAINYYCQEKLYRHMQTVALEAIKKYGADPVLQFFKAYGLILEDRIAEGMRELEAIKDKPDLILCSTMALMYSHKRCKTVDREAVQELDAKLKEERKRTGEKGLYFAATFLWHTGRHDKAREYVDRMLKISQGAKQGQVLRGWIDLTCGRDAYVKKSGKYFEEALSGASKNVEALIGKARYFTLRHNYSGALDQINQAVVSYPGFMPALIEKMRLLMALQDWEQTLETAQRALSQQSNCFEAIRVEILHLLCRDGNYEEAVLRLGELIQLLDRFEPKNGYIYWHLSLVYSRVCGRNAQVLQQASTMVERAVALEPNNAEYKTELGYQLLLKNKPKEAMKFYRNAMKLDETSVAALTGIIKCQLLEDHLDDAEQQLEFLSEIQESIGKSADILFLRAILAHKRAKPIEEVVALLNEASTTHFTALKGIPLGMDYYTQMNPDFVLELVKEYLAFAPTEPQAPGQPVSPILSRCASILEPITKAMPGLLEALHILSRIRFLSGQIDMAQSSLQHCLDRNLQFADAHLLMAQIHLHAGNYKQSSQSLEMGLSYNFEVREMPLYHMIKAKAQRKMNQLDECIKTLQSAMQLPGVKQRAASASKRGSKALPISTTDRVSVYLELAEAYRLTDAQHEAAKVMQDAINEFSGTPEEVRVTIANADLALARGDTELALSMLRNVGPTQSYFVQARVKMADIYLNHRKDKRLYAGCYRELVEKQSSPETSLLLGDAYMNIQEPEKAIEIYEAALKKNPRDSALASKIGSALIKTHQYTKAINYYEAALKTGGQGFLRHDLANLLLKLRHFDKAEKVLRTALDHESANDVSTMMDDCKLLVMLAKVHRHANKMEDSMLALTKARDTQARILKRVQVEQPDAVTSQKALATSICFQMAEHHASQRDYDRAIKLYKEALVYTESDGKAMLELARLYLATDELDACQHQLVQLLQGDKENDNATVMMADLMFRKGEYEQATFHFQQLLQRSPDHYEALSRLVDLLRRAGKLEDVAQFLEQAEKASSRASMDPGFNYCKGLYEWYIGNPNVAVKHFNMARKDSDWGRLAVRNMIDICINPDNETLGGETFENVNTDAMSASEKADSEQMAVRTAEKLIKELKPQPGSDDSKIMENYVLMASKSKPNIEKALSSFMELATSEKENVPALFGVATAYMILKQTPRARNQLKRIAKMNWNPVDAEEFEKSWLLLADIYINSGKYDMATELLRKCLQHNQSCCKAYEYLGFIMEKEQSYHDAAGNYEKAWKYGNQNNPNIGYKLAFNYLKAKRYVDAIDICHKVLANHPNYPKMRKDILDKARASIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWA9</accession>
    <name>A0A8B7XWA9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stomatin-4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110976309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085154.1">
        <property type="nucleotide sequence ID" value="XM_022229462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWA9"/>
    <dbReference type="GeneID" id="110976309"/>
    <dbReference type="KEGG" id="aplc:110976309"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03403">
        <property type="entry name" value="SPFH_stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000002">
        <property type="entry name" value="band 7 protein AGAP004871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="97"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022085154.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="40058" checksum="0F64C0FD0F7F7C63" modified="2022-01-19" version="1">MAASAAAAAGGAAVVNMEMELQNVQQGWKKEGRKTVDKGGNQRPSKKDFQPLDQHEEVEATGFTADSGDNGLGICVYLLMFFSYFIVLFTLPVSLFFCLKVVAEYERAVIFRMGRLLPGGAKGPGIFFILPCIDNYVKVDLRTISFDVPPQEILSKDSVTVAVDAVVYYRVYNPTISITNVEDAQRSTRLLAATTLRNVLGTKTLGEMLIDRDIISSQMQSVLDEATDPWGVKVERVEIKDVRLPVQLQRAMAAEAEAAREARAKVVAAEGEQNASRALKEAADVLAESPSALQLRYLQTLNTISAEKNSTIIFPLPIDLLTGFLGAGRRKSASSPLGSQQGSRPGSRRKKRELEIDEDLDGEPTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXI8</accession>
    <name>A0A8B7XXI8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline-rich protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085599.1">
        <property type="nucleotide sequence ID" value="XM_022229907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXI8"/>
    <dbReference type="GeneID" id="110976547"/>
    <dbReference type="KEGG" id="aplc:110976547"/>
    <dbReference type="OMA" id="DAPMHIT"/>
    <dbReference type="OrthoDB" id="10066480at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330">
        <property type="entry name" value="P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330:SF9">
        <property type="entry name" value="PROLINE-RICH PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085599.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45195" checksum="5DCF55E8EB3267CF" modified="2022-01-19" version="1">MAGSHHRRRHPSYYAKRRRRRRHHPYHPRNQLSEQQQQQQEREETEQQNSSGCSMDESETDIYIPVPVPLLDIGITSWLPLLELGGAWRWCSDKVTQSLDWVKDAVFPSRVYQRELQETKDQLRLLHQQIEQLKEQTLKIKCSKPAPVYKCNCQNSMQVNLSKSHVLQPSGHNPKPTANRRVLPGESIPPPVPAVAPPPPPPPPPPPITLPTKAPVFKKKGAAKSSSQASTGDQRPLVTLSDIMNVKLKKVSDQQSKQPTSDASNQRAVVTLMDIMNIELRKTFKDKKTGASGQHEVGNGDLKAGKLRNRRSLHQNNDENVNGMVLRSRISEEALQYRGCLRKVSMVRSPGGTPLRNKPSESQGTGLTPLMTKALRRKFKTIRTPSPSTQLESISPSFNTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYB8</accession>
    <name>A0A8B7XYB8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110976366</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110976366</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085256.1">
        <property type="nucleotide sequence ID" value="XM_022229564.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085257.1">
        <property type="nucleotide sequence ID" value="XM_022229565.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085258.1">
        <property type="nucleotide sequence ID" value="XM_022229566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYB8"/>
    <dbReference type="GeneID" id="110976366"/>
    <dbReference type="KEGG" id="aplc:110976366"/>
    <dbReference type="OMA" id="EMMHEAN"/>
    <dbReference type="OrthoDB" id="10041854at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022085256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085258.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24008" checksum="FA0A113403BA3191" modified="2022-01-19" version="1">MSMSESSSSEDEVSVSPPSYGVTFTIGGLPLSGSTSAGSPRSPSEAAPASQPPEPEDDNRRREQEKWAMLAGQAAYKLEAYVFRQVLPEELIKPHIFPRNITDMEALIHKYGRSGEAVRLENAKEKWKQLKNKWQWTKAHTAALSVIKFAYLHISNPLEVMMRLDRNDGESLKETRRAFRKSLPTELYEAGDQIVEMMHEANLLKDESSINET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0R2</accession>
    <name>A0A8B7Y0R2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC110977175</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110977175</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022086753.1">
        <property type="nucleotide sequence ID" value="XM_022231061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0R2"/>
    <dbReference type="GeneID" id="110977175"/>
    <dbReference type="KEGG" id="aplc:110977175"/>
    <dbReference type="OMA" id="CDENAIV"/>
    <dbReference type="OrthoDB" id="9423210at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047526">
        <property type="entry name" value="TNR19/27/EDAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12120">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12120:SF10">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034511764" evidence="12">
        <location>
            <begin position="23"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="13">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="249"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022086753.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="63074" checksum="8DD24A0142907305" modified="2022-01-19" version="1">MSSLQCAVTGILLVSVLDRVNGRPARLLLPANDSPSPEDCQAPDEYWDTEKGDCAICVQCGPGHGSTAVECGYGRGEKGTCNACIAGETYQDEVTAGQCKPCTPCDENAIVKSNCTTNQNRVCGPCKPGYGSHSGHEGLCSLCPDFNDAEKPPECDGTSTPLPIIQASPSTVTLISNTNQENVGSTQNVAMETNLDTTFSFTRLSNGTTAKQGTSSLGIGLGIGLGVGLSVILIILLVYCYKICQQCRQPSGPSKPDVVGASQEEKDKLTGDQSGTDHDNTEASGGGDTEAERVTDIDEGAIYSASKQEGSVRLELNAPDQTLPNGALPIDTDNPSSGRPTLEDVQNAQNTKEPGHSSKNGDVTVTPSSSCRHDSTDGNVSPRIMLPTIEESPNGQSASDRPALNRQNSNKFQQILDTFSSKITSHCRPEFKRSISEPADEKKRQDIQQTVSGKQIVLPLTVRKKCIKNDKDRKQKEFDKNFEKACSLGREMKWEDLSSTVRKEVNQMLTEDKKALSSYKDLGEVFGVNRNSQLKVCTSADDIFEVLATDKVPPNMEVILQKLLEIKRCDVVRKVVDNILKQKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y108</accession>
    <name>A0A8B7Y108_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ganglioside GM2 activator-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110977224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086849.1">
        <property type="nucleotide sequence ID" value="XM_022231157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y108"/>
    <dbReference type="GeneID" id="110977224"/>
    <dbReference type="KEGG" id="aplc:110977224"/>
    <dbReference type="OMA" id="WENCGPP"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034804653" evidence="2">
        <location>
            <begin position="21"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="3">
        <location>
            <begin position="50"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086849.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="22204" checksum="44060EE2EA9E2F7C" modified="2022-01-19" version="1">MNFLTTFLIVAVALMPVAYGLSSKIWSKETTFQKLSSAGKTRVGLYGFSFEDCGGSSDPLHGNVSLSPNDPVTLPGKLTVSFNASFGVDVKSPLKVVLELKKKELIWIDLPCVDGIGSCTYDDFCKMLPPEPASGCPPPLKEKGLPCRCPVKAGKYSLPPAVFTIPTIPKVPEFLADGDYKANVKAYYGSKELGCINLTFSLKLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2B8</accession>
    <name>A0A8B7Y2B8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator ATRX homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086445.1">
        <property type="nucleotide sequence ID" value="XM_022230753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2B8"/>
    <dbReference type="GeneID" id="110976998"/>
    <dbReference type="KEGG" id="aplc:110976998"/>
    <dbReference type="OMA" id="HSIGGKC"/>
    <dbReference type="OrthoDB" id="10484080at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086445.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="46050" checksum="43B77F696547289A" modified="2022-01-19" version="1">MKSVFIVIIVAIIAYFLFRPTTFTVQNDIFVYKLPEDVYEFMSDLKRTIEKHSIGGKCTLMKQRTRKDGMREKLYLVEKAVALFWDYELPLNMEIRLTLTKPSEELRYNFNFARGYLLKVSSRITFERREGRVLPGTFLTENLTVTCPWLAQAVVSKSLEESHKDTLISLRNGLEGMPLPKDKTNKMREEMEDRQEERKMRTEKNKEEGTSDKKDKPRKKDEAKKPSDGQEKNISKKEKRATADKDKEKPQSEDAKQKTVEKGKMKDSQAEKQAPTGKQPTADKKAERGTSQDAKEKPKQAKKDEKVKTTETRKEERQAENVKREEDGAKEIKDAEEAKRERKIERNEQVTKKTSDSGKEGAMGEKSVESENRKAPKEEREKIVNSGKSEQKQKAKTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2M0</accession>
    <name>A0A8B7Y2M0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110977508</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022087423.1">
        <property type="nucleotide sequence ID" value="XM_022231731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2M0"/>
    <dbReference type="GeneID" id="110977508"/>
    <dbReference type="KEGG" id="aplc:110977508"/>
    <dbReference type="OMA" id="TGEMDAK"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034998501" description="Multiple inositol polyphosphate phosphatase 1" evidence="14">
        <location>
            <begin position="23"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022087423.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59468" checksum="F75AA5DC2C749EE7" modified="2022-01-19" version="1">MTKFSWLLRTGLLLALLGTLRAQDPLFATETGYDLSFQRNELNQRTLSWRDLARATGGSPPEGLQNCQPAGSYVVYRAGTSFPAEADIGALSALQAKMRRQTVNPSFRFLSQLSTSRIPRTSAGDLAESGRRELQELASRIKVRFQEFFQNPDVDLGRFSFQSTNASKSIDSAVAFVRGLVGLNQICETLSSEGNVTVTCSENSRQSPRIVTPTSAYIPHDPANMDPLLRPYNTRRRCLDTVNKGKTAREVRNFQRSREAMQLKDRVAKRLSVPGAQQLWNITTDEVELLGRICAYYLAMFNENTTWCRLLEYEDLNVAEYRRELEDFWDKSYGFPLNSRVTCPLINDTLEYFDRLSGRAAGAGVRTPLMIFKFADENTLLRLVSLLGIAKDPRPLMFNNYAQSRTRQFRTAKLAPFAGNLALNLFRCEEPQSLFFEDVTFRVQVLLNERPINITFCQDAFCNLRDFRRELMAKAGQCQVQADCNVAFGLNPDGSRPGPGSGGGRGAASTVTPARLLIALAAIIVAKVILVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2R4</accession>
    <name>A0A8B7Y2R4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LOW QUALITY PROTEIN: uncharacterized protein LOC110976869</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110976869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086216.1">
        <property type="nucleotide sequence ID" value="XM_022230524.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976869"/>
    <dbReference type="KEGG" id="aplc:110976869"/>
    <dbReference type="OMA" id="RDICDAN"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43713:SF3">
        <property type="entry name" value="GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086216.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44141" checksum="2BAA6BAE4131A542" modified="2022-01-19" version="1">IPAGSNGEFNLPEELTTMLTXGKDCEVWDPTGKQYLDFSMGWGIALVGHARREVLEAVTRQARLGSNFAYINDKELELAEEIIKLSPAVEQLRFCASGTEATMYCDCLARAFTSKTKMLKFEVGSAMSCSQQSLSVSSSYHFVFSFEGISHLVDGHVLVSPYNDLGQTERFVEQYDLAAVMVEPLHRCTSPKPGFLEGIRAVTRRHGVLLIFDEVVTGFRLAYGGAQEYFGXSGGYPFGVFGGRKDIVGLVSEDHLGVDSRYVWTASSLGGNPISCRATLAALSYEHLHAIGKYLRDGMTKCLADVNVPGHVIGDSPLAQILHCATLVRDFRRQKMQENGAQRRAVMIGLFRRGIFINPMGTKFYLSLKHTMETCDQFLEHPEDTLVEFKRERSQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4F8</accession>
    <name>A0A8B7Y4F8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110977516</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022087432.1">
        <property type="nucleotide sequence ID" value="XM_022231740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4F8"/>
    <dbReference type="GeneID" id="110977516"/>
    <dbReference type="KEGG" id="aplc:110977516"/>
    <dbReference type="OMA" id="WGDETTF"/>
    <dbReference type="OrthoDB" id="5957813at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022087432.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47665" checksum="9A565CD0B83B8585" modified="2022-01-19" version="1">MKFLKFYAALALLGAIACFILVRKVSPRDLNFRLGWYPTTSRRLSANGDGSPGNDIRVKEWLRNKTSEAIHSPHRKEPNPGVSATSKKNNERGIVAVKSTPLKISNPLPQANGKPVGRPVALKQTPQNAETVVTLPKTLNVGGGPRNNINPHDYRLLLDEPRACLDKAGTPKKVFLLVFVTSIHAHIEQRQAIRETWGSPREVRGKGIVTLFLFGYNGNANLQRQLEEESRKHHDVLQEDFQDAYRNLTLKTIMGMKWASTHCPQASYVMKTDDDMYISYDNLIKLLTNAATPSTNYAVGYLITGGTPFRDPANKWYMPREMYPKSSYPTFLSGTGYVVSGDVARKVYERSLQTKYLHLEDVYVAVCMEALNITPRGDANFHNWHLQYSFRNYCRLISSHWAPPQEMRRIWSEQQRRGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4F9</accession>
    <name>A0A8B7Y4F9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein LOC110977152 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110977152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086751.1">
        <property type="nucleotide sequence ID" value="XM_022231059.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086834.1">
        <property type="nucleotide sequence ID" value="XM_022231142.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977152"/>
    <dbReference type="KEGG" id="aplc:110977152"/>
    <dbReference type="OMA" id="CTEVPRP"/>
    <dbReference type="OrthoDB" id="205782at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000041">
        <property type="entry name" value="Inactive ubiquitin carboxyl-terminal hydrolase 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052398">
        <property type="entry name" value="Ubiquitin_hydrolase_53/54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975:SF9">
        <property type="entry name" value="ECHINUS SPLICE FORM 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22975">
        <property type="entry name" value="UBIQUITIN SPECIFIC PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="5">
        <location>
            <begin position="32"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="585"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="783"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="822"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1142"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1274"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="833"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022086751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086834.1"/>
        </source>
    </evidence>
    <sequence length="1394" mass="155752" checksum="A071EDC331C33C7F" modified="2022-01-19" version="1">MASLYQSLASRSRQTASRVWQPRNTSSIIFSKGLLNAPGENNCFLNSAVQVLWHLDVFRRSFRQMGGHACMGNACIFCALKVLFTQLRYSERQSLPPDALRKALAVAFQDEHRFQLGCMDDAAECFENILTRIHFHLARDIKEDLCDAKYCIPHRKFAMTLIEHSVCRCGATSEPFPFTQMVHYVSCTALCAEAKKLKEKHHWSNSVCFGHVLRNAGALGDIRDCPSECGRKINIRRVLMNSPDVVAIGLVWDSDRPEKDHIVDVIDCLGTSLRMPDLFNSVVDEKAKQAALHLVGVVTYYGKHYSTFFYNTALRVWVYFDDATVKQVGPNWRDVVNRCKRGHSQPLLLLFANPDGTPVPTDTAPKETTLLPGYTKMKSPTDVRSSRTHLAHDPHKASNAVKFRSLQPVVEYKPAYTIAEESLQGSKTHDKYVVEIGHDAVQKIQARRDGGHSASQDSYRGKGNYVGKTTVQANQGFDTSLKKPLPVKQPDVETHYSPGGVSSHHNYQSLHIGQNRTNAKTHGDQLHPLSDGLRSDMGYSRQGDDTSDNLSLASFQDLSVPILSAATSAAPDAPQGYNATYPLRHVADPGKPPHPKRLERHESWNGRPNPATDLAPKVSQSWLNGDKKGTVQRHNSFSHGTMSDSQYSIPVQQQDSGQMSKSTNKMLHSIANRNHEGVHYPRKESKMQFGSVPNLNQGFDLRASKSVSVQNIAMAEDGILASAVKNNLQQKRASTSDVPMGMGSSSGHRPLQVNHKQMPGMERTFVSSTGGECAENMQPFWAGQHDQSNSKHSQRTDRDHNPGSESGWNASHLELLNTDRAQSSMSNDHKTNRPSQQHMHNSSPMSGQGLRDRDSVASKDSGYRSRDRSSASSGSLHSIEAPTTTCKGLNTVGAAEKSNEEKQLDKLERDEKVLSWTQDKDTICDEVCAECAILEAQSRQKGDAGDLATALALCTASVAKLKQCLRMDGISPQKWQSLHNRYNNAVLQSRNLHRRLTLLRGLDSLPAYQNDTTPISSSQLLQTGKELDLINLDDEYDEISRVDELKQQVHKLYMQEEKFHNTAVRQGPNVQTPARVWSTDALNGKRTFEESLEAQNNHRGMTSFNRNQNADSASFISKHWLTDSLKPLRREAQRGTAYECQSYGLSKDGRDRNSASQQDLLEDPMRNSSVQQDMYRDLRRHSMTQQGTYKDLRGHGTTLQGMREDPGRHLMTQQWKHNDPRGQGRTQQGIHQDQRRHSMTHQGIHVQTDPWQNNTKTPQNKYGRVINQNQPLTAHMSNVPNCTQGSRTSPNAVNSVTGSETATSAQQRSPNQQETSTNYDVREFHTEQPTASSTMVYHVNAVPSLVAHKAYCTEVPRPKPASNPIPVDRELAAKTNALMNKNLHELAAEWDSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4Z2</accession>
    <name>A0A8B7Y4Z2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Troponin I-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110977986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the troponin T family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088268.1">
        <property type="nucleotide sequence ID" value="XM_022232576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4Z2"/>
    <dbReference type="GeneID" id="110977986"/>
    <dbReference type="KEGG" id="aplc:110977986"/>
    <dbReference type="OMA" id="EAGMVND"/>
    <dbReference type="OrthoDB" id="371899at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005523">
        <property type="term" value="F:tropomyosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006937">
        <property type="term" value="P:regulation of muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045214">
        <property type="term" value="P:sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027707">
        <property type="entry name" value="TNNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521">
        <property type="entry name" value="TROPONIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11521:SF1">
        <property type="entry name" value="TROPONIN T, SKELETAL MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022088268.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="47038" checksum="4F4D8181BB778259" modified="2022-01-19" version="1">MEPEEMDERARRREERRKKREAERLALENGDAEEVDRQLEELRRRREERRRKRELLAAAEAETIETNGPTEETDAERRRRERRERRQREAGLVNDETDSMPAQRQPEENNNEDEMRRKAEEEAAARAQEEEERRRREEEEHERQRQEEEERRRQEEERRRQEEEEERRRQEEAEEEERRRQEEEEQRRQDEEAERRRKAEEKKRKQDEERKRQEAEAERKKQAEAERKKKEAASKTAEPAADSGEAPAPEKKSLGSKMKSGRRMNIKSMMMKKAGEDLKKEADETAAEKAQFITDNVKMVSVEGMSQRDLRSLCERLHDQLMQAESDKYDLEVEIRDRDVDIAELNRRAMEIKGKFVKPTLKKVEKVSKTDQHQHQDFRESLKKHEVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7B9</accession>
    <name>A0A8B7Y7B9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">UDP-D-xylose:L-fucose alpha-1,3-D-xylosyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC110978427</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089110.1">
        <property type="nucleotide sequence ID" value="XM_022233418.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089111.1">
        <property type="nucleotide sequence ID" value="XM_022233419.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089112.1">
        <property type="nucleotide sequence ID" value="XM_022233420.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089113.1">
        <property type="nucleotide sequence ID" value="XM_022233421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7B9"/>
    <dbReference type="GeneID" id="110978427"/>
    <dbReference type="KEGG" id="aplc:110978427"/>
    <dbReference type="OMA" id="THKKTMD"/>
    <dbReference type="OrthoDB" id="1712432at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022089110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022089111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022089112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022089113.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36450" checksum="0B2CA61D6F3EE5DF" modified="2022-01-19" version="1">MTTVMATRKVNVSCVVRFSFLLLGAFLLVKWLQTKSLYSKQLEEMNSKEQVAHSVKASNQIESVAKSSSLPCTLGHDGRHDGVILLTTTNAGFQDMTTNMLESIRRVRICPNITIIAEDEQSYKYLTDKVASPGVHIQKTDSGVMTSDRLRVYGRVYIQFVKKRARYILNFLNKGYDVLFTDVDTFWFQDPFPDFRGNFDIAMRQEAPPSSLTPVFCNGFGYYRATENTLAVVREWVRLMSTTHKKTMDKDVLNLVIKNRKPAVRMKSLDSVKYPDGRVFRDKGWVKKRANTTVVLHLSSVFGHNSKLKKLKDNGLWLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YB35</accession>
    <name>A0A8B7YB35_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 63-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110979170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090433.1">
        <property type="nucleotide sequence ID" value="XM_022234741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YB35"/>
    <dbReference type="GeneID" id="110979170"/>
    <dbReference type="KEGG" id="aplc:110979170"/>
    <dbReference type="CTD" id="160762"/>
    <dbReference type="OMA" id="CYKDTIC"/>
    <dbReference type="OrthoDB" id="6766775at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051876">
        <property type="entry name" value="ODA-DC/CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21694:SF35">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="4">
        <location>
            <begin position="150"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="101"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="342"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022090433.1"/>
        </source>
    </evidence>
    <sequence length="572" mass="66104" checksum="5BE938E04428E699" modified="2022-01-19" version="1">MPRGGQRSASRRSDISDIDADQQMAETELAKLQRQYRIMEGDRNAYSIESQDLIRRQLAEISQLEAEKKELNKDLYLSDSQTNQARDSNNVDRLTELCSIRDDYNQKITEEKDQQREIQDKIRTKEREIRGQHREMGGVHASAQHTQKTQKAIRVKENRLHQANEKFNFMLTQNAKFREEIDSLRVERTRFENIRKKLEKELTELRQEIGEVIDQSTQAYDARDEAQAKMILLKEKADKDCAQHQQEMKELQRIIDHDRKLREFMTVKSKEREEDELLVALRQKREAEEGEKLRRERQEDSIEAYEAAFQRIAEITKETDLNKLVHKFIEVEDRNFALFNFVNEQNNEIEIQQDQIAEIQEEISEFKRQGSAMEEQRMTILKGLEEQQTQAAKDADASDAKLKSVNKILDQLKAGVESLFSKTNCDRSTINNMLGSAAGVTDETIMQYLGLIEQRTNELLAVSMYVDSKGAKEKEDVKVPSMLGKGPIPAPQQLMFMAPSTGDDYDSDQGSDLSDEETRPLTQSELKSRIMKGVLKKEAAASKKGFQYDLSVPSKDLKQKQAMPDKKRGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBK0</accession>
    <name>A0A8B7YBK0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110979277</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110979277</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090624.1">
        <property type="nucleotide sequence ID" value="XM_022234932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBK0"/>
    <dbReference type="GeneID" id="110979277"/>
    <dbReference type="KEGG" id="aplc:110979277"/>
    <dbReference type="OMA" id="PDGTAMQ"/>
    <dbReference type="OrthoDB" id="10072495at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031885">
        <property type="entry name" value="DUF4764"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039946">
        <property type="entry name" value="ZN839"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16116">
        <property type="entry name" value="ZINC FINGER PROTEIN 839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16116:SF5">
        <property type="entry name" value="ZINC FINGER PROTEIN 839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15961">
        <property type="entry name" value="DUF4764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1058"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090624.1"/>
        </source>
    </evidence>
    <sequence length="1164" mass="123997" checksum="78BA01F6AFC5D741" modified="2022-01-19" version="1">MNEAHVNKIPENNTMDIVSMAFSNVSERSDLIEVSSSVSPTTEDAEAGNNASAAESVRCEDGNQIVDVHQSDQVKNRPSPIEIPLPPNAIISVNDQGEQTIELAQVAGDDHQAPDMPDQTCSIEHVEQIEQVETVVHPDEHQPGPAGDVVPMSVGGDGLEAIAFQGTDVGMIGDETCVVPVTISLTDVQNLQQVVGGVHIGPSGESVQVSSTNVAVTSSTPGLSESASSLFSSLASIIDTSSVLTTANMSSASLPASGVTFVSGAGIPLPTVQSLSRSAEAQPPGLCASGAGITSAHSESSTSNGSGARASSAAQFIHNGTTLQKVNFSDGSFLTQKSQLMNAKQTTGVGAQSTDQVGSLPPVQKQDSANIIGNRSVFSPMTLTIRTPPGAPAVNQALINSIVNNAEVQALLKRNPGQPITIVRVPEDPSEKRQHLPGMVTAKVLTNRSPGGGGVPHRQIGRPRKEPGTDEDAKGFPVRRRGRQPGTKIRRKEEDYVPPVSWQPVKSRTRSGRLSRPPGYRTENFKMLYPLERPDNPSSDAEGGSDMEADSGSSVAFTPSGRVKNFKCRSCSKAYIGRGGLARHFLVEPTHGNIDDYALSEGSGAKLDGSTAGDVQNTSNELADSEINNKDVAEESAESPQSLAKDEGEHSRLLKEDVMDLDEEPVTDKATGEPAEEPPPEQPSRGRRGRPPNANKDDPDFRPGTSANKGSVKSKDKRKETMRQALKFLNQEDYMDVCLPRMARHLSPWDFLVSKAEILKEDTPQVLKVLQLFEELLSDVREMAVNCLEKVEDEDEEMGGLYLDEDDDLARVLEFDKGWYKVSAPPAGAAELPFSVSSLLKRTAEAISKDDFTDEDATPVKLRKVEPEEPDMTNNTVQNQVSSQVKSTPKPGPTSDPKSITVHVHNGKVTTEQGSPSIAALRAPLRETVPLSSTDRRLASAENTTDQQQTDSEKLPSSTTLVPNQTSNSVIRRDPPPLALLALEQQPLAPVVLEQQPLNPTDPRKQSAVATEDSPAKEQIAGNGGLPQAQTRSPMALGSPVDAEASPPQDTSAGSAGEQSLAWEGEGQPTSSDGGTQFVHVAEELESLASTADVVNQSDMKVDPTDTVHQQETSVVVPEGSTIMQMQDGTFLVQKPDGTAMQIHTPEGMTIETVQELLSMEAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCK4</accession>
    <name>A0A8B7YCK4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cholesterol 24-hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110979470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090979.1">
        <property type="nucleotide sequence ID" value="XM_022235287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCK4"/>
    <dbReference type="GeneID" id="110979470"/>
    <dbReference type="KEGG" id="aplc:110979470"/>
    <dbReference type="OMA" id="FYDIYGA"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033781">
        <property type="term" value="F:cholesterol 24-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006707">
        <property type="term" value="P:cholesterol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20613">
        <property type="entry name" value="CYP46A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039983">
        <property type="entry name" value="CYP46A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293:SF0">
        <property type="entry name" value="CYP46A1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 46 SUBFAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034130554" evidence="4">
        <location>
            <begin position="21"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022090979.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="49399" checksum="8009C132189A7AC7" modified="2022-01-19" version="1">MKIFGPVFALFMFSKPSVICLEPSCVKKILHSTTHFKPPAEVQFFWSVFGQRYLHHGLLTESNVPKHMKRRALFDPAFHRKYLKTLISTFNQSANVLIEKLTNVADGKTVVPMLDEFNKFTLDVLAKVAFGLDLLEDKGFNKAICKSLTGVEICFYKPWIQWSPLPAHAKFREECREGVRLIRETGRKCVLDRIAAKKRGEKIPNDILTYILQQSNDLQDDEDFTMENMLDEFCTFFIAGQETTANMMAFMLVELGHHPDVMHRLQTEAKAVLGDSDYVKFEDLGKLEYMMLVIKETLRLWPPVIGTSRQLAHDEMLFGYKIPAGTPVWLNTYTMGRNDKCFPDPLVFNPERFIDTSEDRQLFTHFPFSMGIRSCIGQQFALIEAKLIMSRLLQKFNFSLAPGQLRDDVLQEILIKPKGRCKNYLTLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEG3</accession>
    <name>A0A8B7YEG3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110978955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090016.1">
        <property type="nucleotide sequence ID" value="XM_022234324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEG3"/>
    <dbReference type="GeneID" id="110978955"/>
    <dbReference type="KEGG" id="aplc:110978955"/>
    <dbReference type="OMA" id="KREDYQV"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="102"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022090016.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19046" checksum="0147A6C916E2760F" modified="2022-01-19" version="1">MPRKTRASKKPAAAEVGDVINISDDFDLGDSGASKTFPLQCSSLRKGGHVMLKGQPCKIVEMSTSQPGKHGHAKVHIVGMDIFSGKKYEDICPSSHSMSVPHVKREDYQVIGVWDEYVNLLDNKGVSRSDVRLPEGELGKEICTRFEADEEIVVTLMTAMDQEMICGLKKLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEH5</accession>
    <name>A0A8B7YEH5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Dedicator of cytokinesis protein 1-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="14">Dedicator of cytokinesis protein 1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110979850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091654.1">
        <property type="nucleotide sequence ID" value="XM_022235962.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091655.1">
        <property type="nucleotide sequence ID" value="XM_022235963.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979850"/>
    <dbReference type="KEGG" id="aplc:110979850"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11697">
        <property type="entry name" value="DHR2_DOCK_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11872">
        <property type="entry name" value="SH3_DOCK_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000004">
        <property type="entry name" value="Dedicator of cytokinesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.350:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000003">
        <property type="entry name" value="Dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="10">
        <location>
            <begin position="422"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="11">
        <location>
            <begin position="1224"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1653"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1712"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1662"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1751"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1762"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1855"/>
            <end position="1867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022091654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022091655.1"/>
        </source>
    </evidence>
    <sequence length="1897" mass="217429" checksum="31E62BC562545DB1" modified="2022-01-19" version="1">MTGWVPTIEAKYAVAIYNFEGSNSFELRLSVGDTVQILEECSGWYKGFTTRNRRFRGIFPKTYVHVKEASVENRGDVLETVTPKETPVVHELTTVIREWGVLWKQLYVKINRELFNTIHKMMYELIDSQKQIVSGTLPVDELKELKQQVTSKIDCGNRALGLDLVIRDEEGGIQDPFSISTVALFKQHETATQRIGQQQNETFSLGLPKIPKQANVYSYNLFVNLKNVVCRIGEDADVLMSLYDAKEQKHISESFVAKWSSKGIPRDISLLYSLKTIFTDLGAKDLQRERVFLVCQIIRIGKMELKEGDNNKKYTTGLRRPFGVCAMNISDILSGRIETDEDKQHFLPFQASTGEDSLDSMVRKVVVAREINHKGQGIWVGLKMMPGDIKQVWKDYPHLMDSKTAIAKKMGFPEVIMPGDVRNDVYVTLLQGEFDRGNKPKARNVEVSIEVCSSNGMVLEDVIYTAAGEPPSSKYQSVVYYQVKSPKFYETVKVAIPIEEFCQSDTHVRITFKQRSSSETKDRQEKPFGVAYLRLMTDIGTTIVNGEHDLLVYKCDKLQDTISTHYLDLPSTRQELERRHQHQTSSGSGGSSSSLGSTGSLSRSKGYGLSSKDSLQIATLVCSTKLTQNVDLLGLLKWKSDRSNLQANLESLMKVDGEEVVKFLQDTLDALFSILTESPQSNEYDEPVFNALIFIIGLIADRKYQQFRPVLDAYIKEHYSVTFADVKLMRVFKNYLDNAGEKGMQDQLLKTLKAMEYIFRFIMKSRMLFTALHGDNTGKNQFEALLKDVFQSLKWLMTYTADNVLLCQGASMKYLPSTLTDTMTMLEPEELAALVKEFLVSLPPERLVKQKLDCIRDVVHSELFKLRQCRAILVPMMAEFLKNLLTKKEDMRLVADVLSDIVDTLWRKDLGPTHGDISEIMHTLLRTVIQSVVFMYIGNDDTLIGRLVSCLISILNQMTEFHYQEYINSFPTRTDLLDFLMEIFMVFRDLISKNVYPPDWATMIVQQNRVILIAMKQFARVLHRSFVRIDDFEFQLWNNFFHLAVAFVTQESLQLENFSSAKRNKILERYGDMRREVGFAIIRTMWNYLGKNKIRFIPEMVGPFLEVTLVPETELRKATLPIFFDMMQCECNIRGNFREFEREIITQLDALVEGGHGDLQYRELFGQIIGEYCTQNVTRLGNEGLTFIKLVRELMGRLLEYRDVIHDESKENRMSCTVNLLNFYKDIDRQDMYVRYLYKLCDLHLECDNYTEAGFALQLHADRLHWSERPLMTHSDKYPEAQTERQLKELLYYDIVDFFDKGKMWEKGILLCKELQNQYEKELFDYIQLSELLQRMAHLYDKIMKIPRPAPEYFKVMYIGCSFPPFLRNKTFIYRGKEYERLADFVARLQQQFPNASMMNKTTPPDSEQMQSKQQILQVVPVQPLREERKEFKNKTICDQILSYYAVNEVQRFSYSRAFHREAKDKDNEFKTMCIERTYFTTAYRLPGILRWFEVIKTSSEELTPIRNAIDTMEDANSKLKQMIGQYQADSSLPINPLSLQLNGVIDSAVMGGPAKYEQAFCTDVYAAEHPENGIHITRLKELFAEQVALVEVGLMLHRNKMKEDLKPFHQKMEVMFERRKEQVEERYGKKLVEGFALTPNDRMIQSYARRFSRGRADRPLSTMSNSSTSSDTHGSRSSIVSNPDMMSYLQIVSSSVSQHWNFNLSTPRRMSDSATFIKGQGTPSSKTGQHKEKGSGSPAKRNSKDLSAEDSGSNASTPSKEAAKPIILDEKISSARPLRKDMKKANASPLPRPLKAMSMHVPMVTTSPSDEPDLPPKLPPKHAYSDYSSLPLLDAGPSPLPPKKLSLQLGASPLRDKPPPLPDKETSSTTTPMPQMKEPLLVHGSPSKKPTTNNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEM6</accession>
    <name>A0A8B7YEM6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110979498 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110979498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091032.1">
        <property type="nucleotide sequence ID" value="XM_022235340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEM6"/>
    <dbReference type="GeneID" id="110979498"/>
    <dbReference type="KEGG" id="aplc:110979498"/>
    <dbReference type="OMA" id="TDRYVWF"/>
    <dbReference type="OrthoDB" id="59288at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09620">
        <property type="entry name" value="CBM9_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35532:SF5">
        <property type="entry name" value="CARBOHYDRATE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35532">
        <property type="entry name" value="SIMILAR TO POLYHYDROXYALKANOATE DEPOLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022091032.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43823" checksum="42EF85A22148274D" modified="2022-01-19" version="1">MAASSVAKFPSFLRSKLSTKVCIVIFILAIIFSQIRLVICTVTCETLPLPRTDVVYRLGPGEVIEIDGKLIDKAWTEVSPSEPFVDIQGRDFPRPRFETWAKLRYDDTYLYIGGYLQETDVFANQTQHDSVVFKDNDFEVFTDPDWSTHWYKEFEINAINTTWDLILNQPYMNGGFPNSSFEMPTMKSAIYVDGPVNNPLVKDSYWTVELALPLKDLVLNDSMARAPPKNGDQWRINFSRVEWHVRNVNGHYEKVPGLPEDNWVWSPQHVINMHLPERWGIIQFSTGKVNSSKFIRDPKWPMYNSLVEVYNAEKIFNAIAGYYTSNLTQLELPSYVTKGLCAGKPEITVIHNYRFNATVKPLDPSLPMGHVRDDRYIWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YES6</accession>
    <name>A0A8B7YES6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Latrophilin receptor-like protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091087.1">
        <property type="nucleotide sequence ID" value="XM_022235395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YES6"/>
    <dbReference type="GeneID" id="110979529"/>
    <dbReference type="KEGG" id="aplc:110979529"/>
    <dbReference type="OMA" id="CWITELV"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091087.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23912" checksum="4653C661637963AA" modified="2022-01-19" version="1">MSQRHQRRGIDRELVAYICVAYGIPLTIVSTCLTLQFCDCTDLPVIYAEASICWITDATVRAVTFVVPIAVSLALNIVMYVYTVLQVRRTRQASKVVRNEGTADTVKEELSIYVKICTLVGLTWVFGFVSQSVTGILAFSYIYIILNYLQAVFIFLSFCLNERVRGMWRQKVQAKRTGVPTNSTSQPKHGGSTGTATTNLSAISYLNATTENTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEZ2</accession>
    <name>A0A8B7YEZ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Vacuolar protein sorting-associated protein 11 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110979562</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091157.1">
        <property type="nucleotide sequence ID" value="XM_022235465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEZ2"/>
    <dbReference type="GeneID" id="110979562"/>
    <dbReference type="KEGG" id="aplc:110979562"/>
    <dbReference type="CTD" id="55823"/>
    <dbReference type="OMA" id="ENENECP"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16688">
        <property type="entry name" value="RING-H2_Vps11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000164">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000258">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 11 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024763">
        <property type="entry name" value="VPS11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12451">
        <property type="entry name" value="VPS11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="10">
        <location>
            <begin position="419"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="10">
        <location>
            <begin position="600"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="847"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="966"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="804"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="980"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1023"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1099"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1114"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1145"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022091157.1"/>
        </source>
    </evidence>
    <sequence length="1171" mass="132962" checksum="273A3C563EBA5CC4" modified="2022-01-19" version="1">MYVGRTTRVDRQIVSVQSESSIMAFLQQWKRLNFFDKEVVKTPGTSEIFTSLKDIDITACASGRGQVTLGDSDGNLFFLDRNLDISEFRAYELRVTHLCQLKQHNILVSIGQDEPGINPIIKVWNLDKQDKMRHPTCSRITRALPGSNQPSQVSALTVSETLTMMAIGFQDGSVTLIRGDVTRDRHNKFKTIYQDKTPVTGLGFRHTQRNTVLFVATETSVSSFNLSGKDPHREVLDLHGCPLRCSIMSDATQDNQFVMGREDAVYFYQPDGRGPCLAFEGQKTLLYWYRGYLVVVTKDSKMLSRNLGASGQQLVMDTVTVYDIQNKFIAYLAPVPEVLDVFQEWGSLYVLGGDRKLYHLQEKDTQTKLEILFKKNLYSLAINLAKSQHYDYDGLIDIFTQYGDHLYSKGDHDGAISQYIRTIGHLEPSYVIRKFLDAQRIHNLTAYLQALHKQSLANEDHTTLLLNCYTKLKDNSKLDEFIMTKDKEVDFDVETAIKVCRQAGYYKHALFLAEKHSQHDWYLKVQLEDIKDYQKALTYIAKLEFFEAMDNMKKYGKTLMSEVPRDTTDLLKILCTDYKPSDIANFLKVGEEDEPLIDANMLTGDVVPKVQKANAEEFIHIFVNNSGQLMEFLEHMVKVQPDSSHLIYNTLLELYLHDMAHEGERRNRLELHRKAMDLLQTSDALYDIDQALVLCQMHNFKQGILFLYEKSKLYQQILHYHMENNEYDQVIDTCKRHGTQDPNLWVQTLSYFARKEENCKQYIVEVLSQIDRYNLLPPLMVIQTLAHNSSATLSVVKDYIIRRLQQENDQITEDERLVKQYREETEKMRRQMAEMKTSAKIFQVSKCSICNHNLELPSVHFLCQHSYHQHCFESYAENDLECPACASENHKVMDIIRAQEQSKDLHEQFHRQLEKSQDGFSVVADYFGRGVFNRVTLLTDTFPSSPKKLMPSQTGILPAPMQPSRITQAAPARAARPSPVHSQPISLPGTSSTQLPPGRTQTPPQPRSAPSPAPGFQMPTARGASQSFQQEKAKQPQSNPAEVYHASPSRLTPSPNPSVPKSSSPATSHRVPTAPAQEYNPFLMGSGAVLGSARPPSPATSSPAQKTSSPSKAHSYNPQANPFEMGSSQGVKDNINPFTGRRDSPSNPFQSDGASSNPFEEEEDKNNPFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGG9</accession>
    <name>A0A8B7YGG9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979343</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090746.1">
        <property type="nucleotide sequence ID" value="XM_022235054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGG9"/>
    <dbReference type="GeneID" id="110979343"/>
    <dbReference type="KEGG" id="aplc:110979343"/>
    <dbReference type="OMA" id="AYNPTWH"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090746.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11702" checksum="1BEEC36B1325C900" modified="2022-01-19" version="1">MNRGTRPSLIADDPRKKPVVKNADMEEDQQQHAIDVGKQALEKFDVEKDIAAYVKKEFDKAYNPTWHCIVGKHYGSYVTHETKQFIYFYLGQIAILLWKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHC0</accession>
    <name>A0A8B7YHC0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ataxin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091977.1">
        <property type="nucleotide sequence ID" value="XM_022236285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHC0"/>
    <dbReference type="GeneID" id="110980021"/>
    <dbReference type="KEGG" id="aplc:110980021"/>
    <dbReference type="OMA" id="VHSADMC"/>
    <dbReference type="OrthoDB" id="10000452at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043404">
        <property type="entry name" value="ATAXIN1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003652">
        <property type="entry name" value="Ataxin_AXH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036096">
        <property type="entry name" value="Ataxin_AXH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13392">
        <property type="entry name" value="ATAXIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13392:SF13">
        <property type="entry name" value="AXH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08517">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00536">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102031">
        <property type="entry name" value="AXH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51148">
        <property type="entry name" value="AXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AXH" evidence="8">
        <location>
            <begin position="605"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="364"/>
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            <begin position="138"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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    <evidence type="ECO:0000256" key="7">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51148"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022091977.1"/>
        </source>
    </evidence>
    <sequence length="932" mass="101900" checksum="35B6AB9E673DCFD4" modified="2022-01-19" version="1">MSQQGSSSEKQSSAARNTAYHAGFPRQGLPLQYRATDTVHHATSETPHHPSRPPNFAQPWRVEHPLSHHTVSERVYSASPEATRISSMGNKNDPNKSPTSLGSTGALSSKGELLGTTDRQDRNQLKLVRAGSQETRDGSTPTSHPTQPHSSDWLKHSLSQTLTRPSLTDSQVVPLVTPAALADMGHLYKLPTASSPSRPQIYPSGMFAPLYTSASATPPQFPAYTSPSAVQVSTVPTFSPYLHVSGYPLGYPVVAAQGTVEPSPYPTVESYSAMLASMGSQVQQAQGSRLPVTTYLPPGVIPLPYGTQITPGIPGLSLLPKGAVQESVPAVAYINQQLAGPGILQSGPHVLTGLVPVSSSMISFPPRTEDEANRHDQSQEKGGEQEQMATPVIEGAGEERVMQRHSEALPRRTFAAKPHVMFDKPEVPHTAQLQKIEPAVQLTPADRQSEQDRTPYAVTGTRHESVITAVSLSSDKSRPSSQEEHPVYTVGEHSHWGASIERTGAFPISVPPAVQHSPQVRFQLSPSPQARPSPTIIHTPSAETDGVPPPVMPPSTQNQMTYVIPATERVQQNQSHHHPQGAMGHSSPVEPNHSQVQHLLGLPQIPASPFSNIPSYFTRGSVIQLASGELKRVEDIRTEDFVHSADMCEGLKIDSSTVVRINELPDNGVALISFLVGEHKAQVSLEAPMEHPFFVFGQGWSAVRPERSLKSYNLSCHKLAVGDVCVSLTVKDKNGRWLHRPQQSEQPLSQQHQLQPHQVQVYQQLPPQQQRQQQEIPMQSSFSATPKELPSWSPEPKRRLLEPVQEDANWEDKAHLRPATSWQRNSQQHSSSHLEAPLRYTFAVPPPVSATVSSEQPVSEGKLTEQTDSNANMVLVRTTNAVAEEKSQKSSPRTDSKPLQPLKRRWSDPMHRAQLAAEQEKYTLSTKPTESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJK9</accession>
    <name>A0A8B7YJK9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clathrin interactor 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091756.1">
        <property type="nucleotide sequence ID" value="XM_022236064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJK9"/>
    <dbReference type="GeneID" id="110979907"/>
    <dbReference type="KEGG" id="aplc:110979907"/>
    <dbReference type="CTD" id="9685"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16989">
        <property type="entry name" value="ENTH_EpsinR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
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    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="19"/>
            <end position="152"/>
        </location>
    </feature>
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            <dbReference type="PROSITE" id="PS50942"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091756.1"/>
        </source>
    </evidence>
    <sequence length="756" mass="83504" checksum="4173F6DEDDD4D6A9" modified="2022-01-19" version="1">MAMQSAIWKIREIQDKVTNMVMNYTEAEAKVREATNDETWGPHGSLMAEIAKETYTYEHFPEVMSMIWKRMLHDNKKNWRRVYKSLLLLSYLILNGSERVVTSAREHLYDLRSLENYTFMDEFNRDQGMNVRQKVKDIVDFIQDDDRLRQERKKARKAKDKYVGMSSENQPFKYSDRYESEPRMTKSKVKEFDDEIDNFRSKQSRFNLGRLGTGSKAEESDESPPEYGDEDDYGDEDDKQKQFEFKDEENEETVTHTTTTETRTRRSRRSGKKLDLGAAGAYAEEAKTESNSSNTTPTTKTGVDSLLDTSIPATSGNQDLFADFSSAAANNSFHDFDPRGTSPAANNSTDFATFQSAPLSPNAQESSFGDFQGTAFSATVTQQNSTVTSVQATTFNPQPSIVPMQPQSTPVLQPQSTPLQPQSTPLQPQSTPLQPQNAPLQPQQSGLMQPQQNLMQQSNVPLQTMQMGMTMQQQQPLAGGMMQQPQGMGMIPQGGAMQYNQQSLLSMQSPQQFQLPLQSVSGNLHMAPESPTTVAVYDESLYSYMVPHMAAMMGMGKSMGQPMGQQLMGQQPMTSMSSPSSIPSQLPKGQQSNGSITSAPLSTASSTTTPQKKNIWSDVNVDIKLDSLSPGDKYKKQAQPSMNQMQGNKVPGGIGQPQMGNVTMGMSQMNLGQQRPHGGMMGTPMMQQQPQGMMGMPMSVPQQGMMNMGMQPQGMMGMHGGGGMGMSGIQPGMGMAGMQGMAMSGQTQQYGAYSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJM3</accession>
    <name>A0A8B7YJM3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110980792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022093453.1">
        <property type="nucleotide sequence ID" value="XM_022237761.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110980792"/>
    <dbReference type="KEGG" id="aplc:110980792"/>
    <dbReference type="OMA" id="IICACAT"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <begin position="368"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="16"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022093453.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="56527" checksum="D48548D3091CDE01" modified="2022-01-19" version="1">MTGCRSCLDRHWGWVVTAASFVMYLVSCGTLGLFVLLYVYFEREFHGSAAAIGWIGSLGNGLLNLMSLVSSPLYERFGHRRIILLGVVLSSAGILASSFTQALWQNYLTFGILFATGLNFLSNPSVNMMTLYFPGRNCARATALGSSGQSIGTLLLTPLFEALFSGIGWRRSLQVLSVVNFLTCVPLAMVFRPPGPRPVKFDGEAASSPDEKDALNMTEVGNAPGPLAENRDGESHPRTDGQANCQPPSRLAAANPVRENEDSLQREFSVRKGPSDDSDLSAERTTALVPSSGAQPPTHQEAVGDGVVPEESAVLTPNDRVWRKYIDLAKDPRHACYFIGTIGVTVTIVFNAVNLVSCMTVGGIPEPTAAWLITLLYVTDVVVRLGLSLMGGRLPRKIVLLSLASGVGAVGAFLLTRGTSLWIFVVYSVVAGFLRGTIFGLGYSCVVELFGANKAVESLTSLQIAYGIGGLLASSVAGLSYDLTGTYQTTHYTCLGIWLLSGFLYVVVYQWRRVSASWCKSHQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK54</accession>
    <name>A0A8B7YK54_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110980894</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="15"/>
    <dbReference type="RefSeq" id="XP_022093643.1">
        <property type="nucleotide sequence ID" value="XM_022237951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK54"/>
    <dbReference type="GeneID" id="110980894"/>
    <dbReference type="KEGG" id="aplc:110980894"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000017">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000107">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054608">
        <property type="entry name" value="SYY-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22421">
        <property type="entry name" value="SYY_C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tyrosine--tRNA ligase SYY-like C-terminal" evidence="16">
        <location>
            <begin position="430"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022093643.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="53548" checksum="CC614F084CB0D34E" modified="2022-01-19" version="1">MAASMGINSVKCCFVFVNRALACWGKRQVIMSFSGPHLLRRWYSSKRNVLTLSERGVFHDIFPEASDLPKLLTSEPQCIYCGFDPTADSLHIGNLLAIIALLHCQRAGHNPIALIGGATALIGDPSGKTKERAPLQSAVVQSNAASIKSSLERIFTNHERFLWQEDRPLPQIRIMDNHSWYKDLNVIKFLSSVGRQLRMGKLLSRQSVQSRLSSSHGMSFAEFSYQLFQAYDFLHLHREYGCLIQLGGTDQLGNLMTGHDLVQRVTGKNVYGIAIPLVTSSSGDKLGKTAGNAVWINEDKTSPFDLYQYFLRLPDADIERYLKLFTFLPLNEIADIIRLHKKAPKNRKAQKKLAEQVLLLVHGEAGLNRALRQTEALYHTSPASLEQLNDAEVMELFQGAAVTSLLLEPGFSIEMMLDKVKCLPQGERGKLILQSGGVYINNQRITDASLVLTKGDHVLNNGLTLIRVGKKNYYIVKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKK7</accession>
    <name>A0A8B7YKK7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110980510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092955.1">
        <property type="nucleotide sequence ID" value="XM_022237263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKK7"/>
    <dbReference type="GeneID" id="110980510"/>
    <dbReference type="KEGG" id="aplc:110980510"/>
    <dbReference type="OrthoDB" id="8065733at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092955.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="41054" checksum="422B682F9D67C90A" modified="2022-01-19" version="1">MAALEAEVVSLREIQAIELEELKRRQKRRSSLSRPRWTWQSGRNNLWVGVYRVVQPIVAVKVSALEGSSSFDTYALLDNGPTSTEELASQLNIDGKRQSLTLITIAKTKKKIKTTVISLVVRSFDRQAAVNLEKVYTRQAFPINDVNITESEDVKKWPHARGINTPQVEKGKVQLLIGQDSPEALMPLERVIALWEKTLCPKGRHYELPISLKNDQQRLVDNRIVAEQRLTALGRRLEKDHQLKSRYTEDIKELVNNGFAEEVAGDDRTSDTTTWYLPHHPVLDSGKQGNMRIVFDCAVIKAQWSILEHADNQQARSDEQVTGRTPALPTRASGCNGRHSSHVPPGQSVTGMKRCLALFLVARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLH9</accession>
    <name>A0A8B7YLH9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110980214</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092356.1">
        <property type="nucleotide sequence ID" value="XM_022236664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLH9"/>
    <dbReference type="GeneID" id="110980214"/>
    <dbReference type="KEGG" id="aplc:110980214"/>
    <dbReference type="OMA" id="KRHHCNP"/>
    <dbReference type="OrthoDB" id="10464534at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034934265" evidence="1">
        <location>
            <begin position="24"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092356.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24978" checksum="E221B98BC668850E" modified="2022-01-19" version="1">MRRPSSLIVLCLMCAAALRSCVAVKFETLQELLGYHEQQQNPDYETTDEMVEEEFLSSVTTPAMVTHESPDVLPQGHHHSHLVEEGSGLEFDETAVLTTTPAATTALVQETQEPTTTRRITTCCRLGEEAGRKRHHCNPDNYLPRLLRDQQRGHNFKQTNKHPSKSRTQFDKCVSGVIRRLSDEFRTCCEEAYKRMWQTERGEDVHQGDRTHLLEIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLU5</accession>
    <name>A0A8B7YLU5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110980771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093420.1">
        <property type="nucleotide sequence ID" value="XM_022237728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLU5"/>
    <dbReference type="GeneID" id="110980771"/>
    <dbReference type="KEGG" id="aplc:110980771"/>
    <dbReference type="OMA" id="SEFATHT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="37"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093420.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34710" checksum="9F86DEF6B3AF3801" modified="2022-01-19" version="1">MTSVERVCQYIDIEPEAPLETDHKPPPDWPQDGGITLQDTSLRYTEDGPQVLQNISCSIKPKEKVGIVGRTGAGKSSLMTVLMRLAEPTGTIMIDGVNTTLIGLHDLRKKVSFIPQDPILFSGTMRKNLDPFDEHADCDIWRAIEEVELKPAVEELPDKLEAVLTEGGTNFSVGQRQLLCLARAILRKNKILIVDEATANVDVRTDRLIQATIRQRFKHCTVLTIAHRLNTIMDSDKVMVLDAGRLIEFDEPYILLQKEGSTFTRMVQETGKAEEAKLFHIAADKHAEKTAHDPEDADNLSVCNMKKNQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMF3</accession>
    <name>A0A8B7YMF3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MIS12 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110981015</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093842.1">
        <property type="nucleotide sequence ID" value="XM_022238150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMF3"/>
    <dbReference type="GeneID" id="110981015"/>
    <dbReference type="KEGG" id="aplc:110981015"/>
    <dbReference type="CTD" id="79003"/>
    <dbReference type="OMA" id="DYLFEMM"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093842.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27434" checksum="3E93DE4670446921" modified="2022-01-19" version="1">MAESYAASDESRDGPSMTADLKEYEVQFFGFTPKSFIDGVHNALVDYLNDSIEVMEKYLLEEAEATSNPVSRECVREASDKLFGHFLKAVDKNFDRLESYLKKNLFHIPSNVLLPEDAVHWQDYSAKDDAKLDADLENLRQQVRNSLYVNARLRQWLQEAEVAQAQLDGFLLRVNNLHQILSKAKISDLSESIIFTAGKARKLKEQLNLVLEQNFRESQERQFTNLPAAMPSKLCNPNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YP82</accession>
    <name>A0A8B7YP82_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="22">AFG3-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110981305</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094477.1">
        <property type="nucleotide sequence ID" value="XM_022238785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YP82"/>
    <dbReference type="GeneID" id="110981305"/>
    <dbReference type="KEGG" id="aplc:110981305"/>
    <dbReference type="CTD" id="10939"/>
    <dbReference type="OMA" id="ARQKGNF"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000001">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="20">
        <location>
            <begin position="343"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="68"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="762"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022094477.1"/>
        </source>
    </evidence>
    <sequence length="801" mass="87893" checksum="F176EA687184B01B" modified="2022-01-19" version="1">MALRCCGSLHLGVRGLSFRLVSPSTKNSGQNIALLQRCTRLFSSTQRVSNAFRNWLVFSKEPPKGFEKFFPGHKKGAEPPRPKNTVSAKDKGPGEPTPGRSSESNRGADSSGNKPNDFWKGLMGSGGSKPGGGLPRGTNPPIDPNNRNQLLFSIAVTVTGAAAVAWLLSGGSAPEITWKDFCQDYLMARQVEKLEVVNKKYVRVWLRPGHSKGRYVWFNIGSVDAFERNLENAQLDLGIEPNNYLSVVYSSESDGSFLLSLIPTALMIGFFFYLFRNNPATGGRAGKRGGIFGFGETTARIIKEDVGVRFKDVAGCEEAKLEIMEFVNFLKNPQQYIDLGAKIPKGAILNGPPGTGKTLLAKATAGEANVPFITVSGSEFLEMFVGVGPSRVRDMFSMARKNAPCILFIDEIDAVGRKRGKSNFGGQSEQENTLNQLLVEMDGFNTTTNVVVLAGTNRPDILDPALLRPGRFDRQIYIGAPDIKGRASIFKVHLKPLKTAVDQEAMSKKMAALTPGFTGADIANVCNEAALIAARHGCKEISSSHFEQAIERVIAGLEKKTQVLQPEEKKTVAYHEAGHAIAGWFLQYADPLLKVSIIPRGKGLGYAQYLPREQFLYTKEQLLDRMCMTLGGRVSEQIFFGKITTGAQDDLKKVTQVAYAQIVQHGMSDVIGNVSFDLPQQGEMVLEKPYSEATAKMIDEEVRKLIQTAYDLTMDLLTKHKDDVEKVALRLLEKEILNKEDMVELLGNRPFAEKSTYEDFVEGTGSMEEDTSLPVGLKDWNKQKEATKDAPEGGKLQPETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPN1</accession>
    <name>A0A8B7YPN1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TSC22 domain family protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TSC-22/Dip/Bun family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093391.1">
        <property type="nucleotide sequence ID" value="XM_022237699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPN1"/>
    <dbReference type="GeneID" id="110980751"/>
    <dbReference type="KEGG" id="aplc:110980751"/>
    <dbReference type="OMA" id="TEQIRDN"/>
    <dbReference type="OrthoDB" id="8961796at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21936">
        <property type="entry name" value="ZIP_TSC22D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047862">
        <property type="entry name" value="TSC22/BUN_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46745">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46745:SF1">
        <property type="entry name" value="TSC22 DOMAIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01289">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="399"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022093391.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="49098" checksum="4C6E3E17A20118B1" modified="2022-01-19" version="1">MEKTDKHPSNPSVGMRKEVGQVVNSAGTAAVNKFDPDEDPELQYLDQDKMNNSKKKSFFQITSVTENVNDENDSMDELDESRADDLSTTDLSKLSLQTDMEQSESDDSPNPPGPGTVIHPNAAMNPNVDTNGNGPSRFKLVKVARIEPIKRGRWTCKDFPTEPQSCPESAAAKTEQIRDNVSGSSSAASSVHYVPGENPPTENPLGDANPAPQQLPPPSIDNATKEASAANDKDSSSVLAAHRPSSKSDSSKESLSKKESSAGDLLSLDSLNVEMLADNQSENDESTSATGGAIDNKIEQAMDLVKSHLLFAVREEVEVLKEQIKGLLEKNEQLQRENNLLRQKQSQALPPHLPYSQSEAAPPHVGAGPPAGQDQGGFPTLTGPAAPRVEGYQPGAGEQPPFAGLQPLPGAAPAQQQTLPQQQAGQFGHLQQAAPQQQPPQLTLPQQTSTQLNQPPSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQA1</accession>
    <name>A0A8B7YQA1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor SPT20 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093606.1">
        <property type="nucleotide sequence ID" value="XM_022237914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQA1"/>
    <dbReference type="GeneID" id="110980876"/>
    <dbReference type="KEGG" id="aplc:110980876"/>
    <dbReference type="OMA" id="MNVCSPE"/>
    <dbReference type="OrthoDB" id="10662377at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093606.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41811" checksum="27B6EEB1D34501DC" modified="2022-01-19" version="1">MEQPTSPLGGGESEMDFSMSVCSPEAMAYSLFEERESPPPSTTTAAEVPIPPPPPLPPVPVNLTGNRTASVIMSAFPIVTIPQTTMVTPTIIQVQQIQQVPQPRLTLQPIQTQTIQSVQPTVQHTITPQQLQQLTVQQQLQLQQQLQQQGLRIQGQPQLVLTQAQNQPIQQVQLQQQQQQQQVGTPQQLLQRQLLDQQQKQAFKLQQQQPVVQQLQTVQQQLQHKKQQMLQLQQAQIAQQGQQIQVQQSPGTQPGPLQLQQLQQQQLQQQIQQQQQQMQQQLLQKQQQAQQQQQQLLQQQALQQHEQQQVQQQQLLHQQQQEQRPQKPLIDPMDLEAKSPQHSVEEVSITENLEKKKDGQHAILAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRH2</accession>
    <name>A0A8B7YRH2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110981086</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110981086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094001.1">
        <property type="nucleotide sequence ID" value="XM_022238309.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094002.1">
        <property type="nucleotide sequence ID" value="XM_022238310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRH2"/>
    <dbReference type="GeneID" id="110981086"/>
    <dbReference type="KEGG" id="aplc:110981086"/>
    <dbReference type="OMA" id="NEEAYME"/>
    <dbReference type="OrthoDB" id="10414247at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022094001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094002.1"/>
        </source>
    </evidence>
    <sequence length="569" mass="64266" checksum="6574BDA91F12F0B4" modified="2022-01-19" version="1">MAWSGEGSEYDEGEDEETATDIDDLPDEELIVVLRDEQNSIKEAQRLIHKEIKSIRRELKRLIRHYAAAHPNQQVDVQQHQRIRSVDSGLGEVNYSTDYTTASEVASSHEDSEVGYQAFLDHDTDQLVTPLKGDGMYSQQSSEVYEAGTGCEEEGSTVLPPPNYKGSFEHPSKTENGFRSGYGIPLHWSNSEITPALDDHTRGKNSTYEDAYSMVRRRHSADKPLKNSTSKSSGNRWKSIIHKHGQKIYSIPESHQNHLIQESVQSSGDESLSFQDLTGYRNNEFDQPRRYSCSRLQSRTERYSTRQVKRTQSAQHIDVRKDTMSGSDSSATNGNQGFPRPNMPILKKTDSSRFLLRPESGNEVLSDRPPSVASDTSERTSSIRQWNGKSRMPAQSSEDEVRDLPRFSDRSYDCYFDAESYNQSPHFSPGLSKRTGSSKHHQQQGVSPTRIKRASSSPSGTSKNTSSARSRNARQSHTNRDDIHRNAFMDENWNAEPLPESQSDLSYPSNEEAYMESYTDHAAQQYRGQKHPYRTSHTKNRDTCNFLKDVGGSPTHPLMKAKGLVSSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRN8</accession>
    <name>A0A8B7YRN8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Gamma-tubulin complex component 3 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110981665</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095125.1">
        <property type="nucleotide sequence ID" value="XM_022239433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRN8"/>
    <dbReference type="GeneID" id="110981665"/>
    <dbReference type="KEGG" id="aplc:110981665"/>
    <dbReference type="CTD" id="10426"/>
    <dbReference type="OMA" id="MRMMSVC"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF14">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="254"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="561"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022095125.1"/>
        </source>
    </evidence>
    <sequence length="912" mass="104260" checksum="E7999E890A4CD5DD" modified="2022-01-19" version="1">MASGASGPSNPQTLLLKLVRHMLAKPKDEDVTAQYQYALRVISSNFTPSVEGDEFQVSQRIQRKLARQGREADAARFAELCRKLQSQNLLQNRWAVMYLLMSLSNDKKSARSRVAEGAAIFGGGLPRMATSTPFESRPMSRQPTPPDHTLSMMQERSHSSGIGSTLSSISGHGQTVSLTSNFNTPRDMYTPAGDTQPVSARLARMLIGDSAKHQTYTVPPAHRQARMTPAVTFALSARDATDNTASEVPEASLVRDLIYVFQGVDGQYIRYHPAEDAFCVDHQAGVSKPTRDLVHKLAELGWLFLRVRKYIDSRSRDNAMGIVGQSFCAALQQELTEYYRLLAVLEAQQQQQEQDPGLSDLNTDLTLIRLKVWTYDPIHRMKYLAILVDGCKDKKGGALASAVHSYTLHGDPSVKCVMKHILKLVAFPIKTMLDRWIEDGDLDDKFHEFFVASDPLVKEDRLWHDKYSLRKSMIPSFITMEQARKILLIGKSINFLRQVCLDNSPIKGRGDSDSVTKNKYQDTEMLLEQDLDASFQQVIDSAYRDTSKRLLYVLYTNFKFLDHLKAMRRYLLLGQGDFIQHLMDLLESDLSKQANQLYLHNLTGMLETAVRATNAQYDDAEILNRVDVRLLELSHGDTGWDVFSLDYHVDGPISTVFTPQCKILYLRVFNFLWRAKRMEYVLARVWRDTTGSTRKLEAITELAPIFHQCHILTAEMVHFVNQMQYYINFEVMACSWDELWKKVTEAEDMDHIIAAHEVFLDAIIKGSLLDEESQPLLTQLRAIFDLIIQYQEVQESLYNDSCEELRQRGANKQAIQERTEQGEWGLTAQAEQDQKRRRAKFLREFIPTSRAQLKVLRKSFQDMVQRFLVMLTGHSDDSLRLLAVRLDFNEVYKAKEPMLRSPMAYNRTKKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRU0</accession>
    <name>A0A8B7YRU0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110981796</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095407.1">
        <property type="nucleotide sequence ID" value="XM_022239715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRU0"/>
    <dbReference type="GeneID" id="110981796"/>
    <dbReference type="KEGG" id="aplc:110981796"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022095407.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21956" checksum="2CB57B4F4F0A4FEA" modified="2022-01-19" version="1">MAVPPGVPPIDHLHNNQDRQIINQLFFKNHEQQPFIALKSTQHTSTIRAKKNTWDDDVRRFLTYLCDYHYEEEWWEIMKKPLPLLKKNGNIKHQTPWKKSQEDTEHQQIYIKNEKKASKQPFMYIRGKLYMYGEDIAMKSYMRMEQNQKLRSMAGGPPQPDYEPLEPYMYDEPPEPDPIHAHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSR1</accession>
    <name>A0A8B7YSR1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110981843</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095505.1">
        <property type="nucleotide sequence ID" value="XM_022239813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSR1"/>
    <dbReference type="GeneID" id="110981843"/>
    <dbReference type="KEGG" id="aplc:110981843"/>
    <dbReference type="OMA" id="SHTRDEF"/>
    <dbReference type="OrthoDB" id="10458131at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022095505.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32917" checksum="B8532F210FB32E37" modified="2022-01-19" version="1">MPIQKTSGDLRGSLDFENDSSDEWDDTLQGTDVICITPPIGYKPKARAGHNQVYLSKMILQRMNRLSGPRESQRAREVFRRYEERRQAARQMLKQSSRSSPPSRSFRSHIQNEIDYSSDFTEDEDDASCFGCVSRRSVAKETSSGGEEVLTSSDEELHFLMAESDKRIKRSPSVGDAEKHSRRGGGQKGKSARTAAEGTAKENMLDDGRHFNLPHDRPLDPWRLPPIDNLSKKGPVNLVKKPPANPDPTSEGLATTSVSDQQLMKSLRVRERKFKKLARKKKNKKQYAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSV6</accession>
    <name>A0A8B7YSV6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">26S proteasome non-ATPase regulatory subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.</text>
    </comment>
    <comment type="function">
        <text evidence="1 8">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases and few additional components including PSMD2. Interacts with RPGRIP1L. Interacts with CRY1 in a KDM8-dependent manner. Interacts (via C-terminus) with phosphatase UBLCP1 (via ubiquitin-like domain); the interaction recruits UBLCP1 to the 19S regulatory particle where it dephosphorylates 19S subunit PSMC2/RPT1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096378.1">
        <property type="nucleotide sequence ID" value="XM_022240686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSV6"/>
    <dbReference type="GeneID" id="110982349"/>
    <dbReference type="KEGG" id="aplc:110982349"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="10">
        <location>
            <begin position="47"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="11">
        <location>
            <begin position="850"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022096378.1"/>
        </source>
    </evidence>
    <sequence length="905" mass="100222" checksum="A1C5686D39FA63F0" modified="2022-01-19" version="1">MAPVEADKKTPEAEKKSQKEESKNDKKVEEDKEADLSEEDRQLQEELTMLVERLTEPDNTLYRPALEQLRQMIRASTSSMTSVPKPLKFLRPHYGTIKEVYNKMVEGENKRFCADIISVLGMTMSDNRDCLNYRMLGSKEDIGTWGHEYVRHLAGEIGQVWAETEEDSAKEQRERLLALARQIVPYHMKHNAEAEACDLLMEIEKLDLLEEFVDENAFPRVCLYLTSCVNYVPEPEDSILLRTALGIFRKFNRYAEAMRLAIQLNDMELVEDIFTTCKDSLMQKQLAYMLGAQQIFLELNEEIEDYEDLTEIMSNSQLNINFLALGRELDIMEPKVPEDIYKSHLENTRPFGASGTQVDSARQNLAASFVNGFVNAAFGKDKLITEDGNVWIYKNKEHGMMSTAASLGLVLLWDVDGGLTQIDKYLYSSEDYIKSGALLACGIVNSGVRNECDPALALLSDYVLHANNTMRIGAIFGLGLAYAGSNREDVLSLILPAMSDSKSSMEVVGITALAAGMLAVGSCNGDVSSTIIQTMMEKTPLELKDTFARYLALGLGLTYLGKQEAVEATLATLDVLPEPFKLFAKILVDICAYAGTGNVLKVQNLLHICSEHIEAKAEPDKKDEKSSDKKDKDKGSEDSVADLAAHQGVAALGIALIAMGEEIGSEMALRSFGHLLRYGEPVIRRAVPLALALISVSNPQLQILDTLSKFSHDTDAEVAHNAIFAMGIVGAGTNNARLASMLRQLAQYHYKDPSNLFMVRIAQGLTHLGKGTLTLSPYHSDRQLLSQVATAGLLATIVGFLDVKKTILKSSHYLMYGLVSAMRPRMLVTFDEELRPLPVQVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAYGERAELATEEYLSLTPIIEGFIILKKNPDFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSX1</accession>
    <name>A0A8B7YSX1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Ras and EF-hand domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110982355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096393.1">
        <property type="nucleotide sequence ID" value="XM_022240701.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096394.1">
        <property type="nucleotide sequence ID" value="XM_022240702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSX1"/>
    <dbReference type="GeneID" id="110982355"/>
    <dbReference type="KEGG" id="aplc:110982355"/>
    <dbReference type="OMA" id="RKNCKYF"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001822">
        <property type="entry name" value="RAB family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="54"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022096393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022096394.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="81851" checksum="079AAAE768747225" modified="2022-01-19" version="1">MESQLATSDMVPSPDDMKRIIADKARELFIVCDKEEKGFVCRRDMQRLDGELPLSPEQLEEVFDSLDDDGNGFLTLEEFTDGFGGFLGLNLDPDIEDESDKAEKDVFEDEKLDDDALENDYHKVMDSLGATGIFEEQDHVKDLWKNLRKNEPELLGNLEDFIQRVCMDMRKAQLTTGELENALKTRGTAHELEVKRLYEEMELQIRAERERILHEEKEKEKRVREELTSLMRGKDEQLQELSKRQIELETKLKSLSDLEDDIKQENEMLQKTNFELRTKLDGSLMDLDESKTYLKDIQVSMKKEKRDRAHAALKVTENIMEERESLVKQLNLLRTMNKKLQDEKDEYESRLRAREAQTESQTQNAPLVKQGSVLAPYVSPARDRIKGQSRQDGVDEEEGYIIDEEDEVEVDDDVYLNGHGTPLHGVINGGLPADGVEGERMDLALGHQWRKERTEGGVDEMDGGIIKQSAQNVYSSAPENKLGAPNSAENGVGVAYKPSGLREEPVGCHSANQTMTEATRMAASPKGPERLFKVVFVGDSGVGKTSFIHRFCHDDFRPSFSATIGVDFQVKTLAINDSLVALQLWDTAGQERFRSITRHYFRKADGIIIMYDVNSENSFINVRNWMNSVVESTSESVVRMMVGNKTDMSEEGESGNRQIKEDVGKSLAESYGCLFYETSAKSGQNVKEAFHTMASILQEREDEDIEKALNLSDEPAEKGCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTW7</accession>
    <name>A0A8B7YTW7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Type-1 angiotensin II receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096739.1">
        <property type="nucleotide sequence ID" value="XM_022241047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982557"/>
    <dbReference type="KEGG" id="aplc:110982557"/>
    <dbReference type="OMA" id="NITIMIV"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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        <location>
            <begin position="33"/>
            <end position="56"/>
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            <end position="190"/>
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            <begin position="45"/>
            <end position="153"/>
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            <begin position="212"/>
            <end position="232"/>
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            <begin position="215"/>
            <end position="226"/>
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            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
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    <sequence length="232" mass="25309" checksum="568D19953F3083DB" modified="2022-01-19" version="1">MDALSISNGNNTLGGETNESIYRTYAERQINSAATFVASFVGFFGNLTVICAILAVKKLQTTTNVFVLNLAVADVLTCTVSPLQALTVLHDELLIPSWLCKLVAFCLITCIGCSINCLACIAVNRLVGITTKADSMYRRLYTPGKLTIMVALTCPYFLMQGLPAEVTRSVLTYTSTILMINSSVNPIIYATRHPDFRAVFVSKVHCWKNSKSRTKNTVPSSGQGXLQSRDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YU33</accession>
    <name>A0A8B7YU33_ACAPL</name>
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        <submittedName>
            <fullName evidence="5">Wnt inhibitory factor 1-like</fullName>
        </submittedName>
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        <name evidence="5" type="primary">LOC110982106</name>
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    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095975.1">
        <property type="nucleotide sequence ID" value="XM_022240283.1"/>
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        <property type="entry name" value="Wnt, WIF domain"/>
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    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="WIF" evidence="3">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022095975.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18299" checksum="4E222819ED8C9B72" modified="2022-01-19" version="1">MLTWMIDSLSRDGVSIWIDEDQALRLSGQETNLFILQDGQVGELLQTLETEAGNGSQPSIAVDVSLLNVTWQAPPHYKYRFRLRSYTRKVMRTPTLNIPEKGIIPVTESGFQIELPCKSDGFASFLIALKIIPPHRRHTPVIQLAQVLRKTCSMDGNNHTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YV44</accession>
    <name>A0A8B7YV44_ACAPL</name>
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        <recommendedName>
            <fullName evidence="2">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110982326</name>
    </gene>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the CLU family.</text>
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        <property type="nucleotide sequence ID" value="XM_022240663.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular distribution of mitochondria"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clustered mitochondria protein homolog"/>
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    </dbReference>
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        <property type="entry name" value="Clustered mitochondria protein homolog"/>
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    </dbReference>
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        <property type="entry name" value="Hypothetical protein (hspc210)"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
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        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
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    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
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        <property type="entry name" value="GSKIP_dom"/>
    </dbReference>
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        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05303">
        <property type="entry name" value="GSKIP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Clu" evidence="4">
        <location>
            <begin position="477"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="775"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1076"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1485"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="813"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1086"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1497"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022096355.1"/>
        </source>
    </evidence>
    <sequence length="1537" mass="170348" checksum="9015D7FA470876DA" modified="2022-01-19" version="1">MAEDSVVENSKSEKESQVNEVVTESEPPCKGDSPVKLADDAGLKLKAASSGQPSAVHGQGGGDADCKPAVNGLNNSLVHNATLPNGSLESTEAANEHDQPNSSIDCAPPVADTDKNSPVLNGHAEDTSSVDIDRKSEATDANGKKDAAESSSEDIPAENMVEDVEGDKTKRTESEGKEAKRDSKVEDVIVIQDTAFTVKIVPPGSEPFELQVSPQEMVQEIHQVLMDREDTCHRTCFSLQLDGNVLDNFAELKSVDGLKEGSIVKVVEEPYTVREARIHVRHVRDLLKSLDPSDAYNGVDCQSLSFLTTVLNDDRKRTKSSDSVDCTPPEYLMPLSKERPLSHLQPVHKESRSPTCLKVLTVSGWNPPPGTRKMHGDLMYLYIMTMEGTSHHVTASTRGFYVNQSTQEVFNPKPADQKHSSHSLIELLNKVSPVFKKNFAQLLKKRSQRHPFERVPTPFQVYTWMAPQMEHTIDSIRAEDAYTSRLGYEEHIPGQTRDWNEESQTTRELPRKNLPERLLRERAIFKVHSDFVAAATRGAMAVIDGNVMAINPGEDTKMQMFIWNNIFFSLGFDVKDHYKDFGGDAAAHVAPSNDLQGVKAYNVVDIEGLFTLGTVVVDYRGYRITAQSIIPGILEREQEESVIYGSIDFGKTVVTNDKYKELLTKSAQQLKILPHKVINHKQDEVEIFSSIECKGIKGNDGRHYILDLLRTFPPDINFLPIEGEDLSEDVKALDFPRKHRHKLCCLRQELIEAFVEHQYMVFVRHAAVLLMQQQKPEAETAPKESNNNTDQTDLEKDAENTAKTDTLKETDSVLGNPSGETNSEPGSAETNGELANGVEEAQESQVGSKKSAEDTLTDSLQDAANAVLAGGKCPMLNGLDASGIEQLAENISSVTEEAAKALTESQKKEIVDSGHKEIITKAAKAAGSLSLTEFDIRFNPDVFSEGVTHADPDSEVFQRQKRVVKDAARFLLVGQIPTFIRECLEHSVAPLDGLTLTEALHQRGINIRYLGVIATIVSTIPPLSYLHRLLVSEMIIRGAKHLFKAFMQGVGMVSLSGAISHFLNCFLGSLPNPQPPKADDEISNGHGKKKRNKKKTGRLLTALGHDCIVWASLTPMEMWTNLKAEANEYYHFKLECDNVDSALEAYSLQRVTLLREFCTKCGIQLLLRDYDFDTKHRAVFGENDIINVFPVVKHINPIASDAYNFFQSGQAKIQQGQLKEGYELINEALNLFNNVYGPMHPEIASCMRNLARLNYLMGEHAEALEMQQKAVMMSERCNGVDHPNTISEYMHLALYSFANGQVTSALKLMYRARYLTLVVCGEDHPEMAHFDSNIGLVLHGVGESDLALKFLERARETTLKYHGAKSLKAALSHHLVGRVYSSRGDFRTALRHEKEAYSIYREQFGEHHEKTKESSEFLRQLTQQAVNFQKTMNELRKGNSRAAMHPIPFSLPSMSGVLDTLNMINGVFFIPISIKSKGLAKTTTKSNAVKSEEGQSVPKQDTETPSDSKVVSPGPSSGKASPTLETEGSTEKGEVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVH4</accession>
    <name>A0A8B7YVH4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ribonuclease III</fullName>
            <ecNumber evidence="5">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">LOC110982529</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022096692.1">
        <property type="nucleotide sequence ID" value="XM_022241000.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982529"/>
    <dbReference type="KEGG" id="aplc:110982529"/>
    <dbReference type="CTD" id="23405"/>
    <dbReference type="OMA" id="CGFHKYF"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016441">
        <property type="term" value="P:post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10843">
        <property type="entry name" value="DSRM_DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000023">
        <property type="entry name" value="Endoribonuclease dcr-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000015">
        <property type="entry name" value="endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000628">
        <property type="entry name" value="Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000005">
        <property type="entry name" value="Putative endoribonuclease dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000002">
        <property type="entry name" value="Putative Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044441">
        <property type="entry name" value="DICER_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048513">
        <property type="entry name" value="Dicer_PBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048512">
        <property type="entry name" value="Dicer_platform"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20932">
        <property type="entry name" value="Dicer_dsRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20930">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20931">
        <property type="entry name" value="Dicer_platform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="17 21" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="18" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="27">
        <location>
            <begin position="436"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="28">
        <location>
            <begin position="641"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="25">
        <location>
            <begin position="926"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="1332"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="1654"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="23">
        <location>
            <begin position="1845"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="428"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1124"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1425"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="1146"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_022096692.1"/>
        </source>
    </evidence>
    <sequence length="1910" mass="216059" checksum="B532753AE44BD8EE" modified="2022-01-19" version="1">MMEAEIIPHGSSYKINRSATNEGVTATQTFTPRQYQVELLDAALDHNSVICLQTDTSKTFIAVMLMKELSKALRLPLQEGGKRMMYLVNDVSTVLQQASVIREHTDLSIGEFISCSSVDDHFSVAEWKQKFVLCQVIITTAKVFLKVLEARLVCPSQLNLLIFDECHLATDKHPYCEITRTLSERTDLSCLPRIMGMTASILHSKCEPETLEKKLKALEQTLKSVVETYSSGCLTRFCAKPKEAIVACKVEEGFKNISKLVHNVLNESLLFMQECSVQYNAVEGDPLMPVERAIRECLMTFEAIGPLGLRIMVPMLLKKLQRIEKRASNSLSKLILHYGCTQLRLARKICESSIVELEDPLDLRLTTPKVRRLLEVLKEFQPSEESEAGFEIQETVRRPNRTLGGGILHKMHNERLTSNRLHPVYSYDDEEESNSDDEDHDKEENTDAQGETNMYGIVLVNRHFLALVLDKLVHKLQRKDPVLAFINSSCIVGHHQGGVEVLGVTKEQQFKKQEEILRRFRRHEINLLFATSALEEGVDVPRCNLVIRFDVPDHYRSYVLSKGRARAPNSHYIMLVEEANLEPFTRELGNFQEIDKILQRKCHHREQQCWDETDLQEADSLCAPYRPNKAEDAGMVTMTTAISLVNRYCSKLPSDTFTHLSPKCHTAPMHTGTGPVMYQSQIFLPINSPIRDPIQGPPMPKRKLAEMAAALKTCETLHKAGELDDNLLPVGKDTVLLLEDFGYEQEVVEEGQGRPGTTKRRQYYNKEVAMCLKSCHPSINQPCHLYEIHMSLASPLPEVLNVRDRKLHVPEETTQCFGILTTKIIPKIPGFPVYTRAGELVISVDLLTSDITVTSDQLNQLQRFHSCIFAEVLRLEKPNLEFDTEKAEANYLIAPLNKSDEDQKLHIDWNFLKTVSESSGMLDRPPILPDYSRNQFVFSHEAFADAVVTPIYRNIDQPQRYYIADILNNLPVTSPFPSEKYEKFIDYYFERYDIQLSNYQQPLLDVDCMSSRLNLLTPRYLNHKGKALPISKTQSKKNYLQKKQYLVPELCYIYPIPASLWRKAVCLPSILYRLNSLLVAEELRVQISMGAGVGVAELPPDVYPFANMTFGWEGLELQNLENQNKQPGEAKDGSTVERTGGSPKGTETKQEKNENSKLKERTSCCLDTESLGEAGNITLLKKMNGEVKGQKYLDHSTVGLNSKTVTGTEQDAIAKEMCSREGHNDGFKSTIPPELNSSNLEKTDKAKVNLKSEGALVRHHKLEVSPASSREKMACASSPSEGYCRCLQERNQNEFDEASRGRGGYTLKLSVLDDQGHDPASLPGPSPTTILQSLTMSNSSDGFNLERLEMLGDSFLKQAVTIYLYCTYPRRHEGKLSYMRSKQVSNFNLYRLGKGKAIGQKMQVALFDPAINWLAPCFSVKENAPTEEQPSYKSYQKEGSDLSSDDGDFAIDTWDPSSVDMWDSNAVIEEETAPDFEIPMMTKEDMDSDFSDEDPTYQYPDRSFRSLDPWTFSLEDADNLPGLTYTGRKPDDMGDLPELPYEIHTQHNLSDKNLADSVEALIGCYLISCGFRSALIVMSWFGLRVLPQICEGAPCDSEAKVVDELVTWEQEYSENQNNCKKPQARYGYLKQPESPFFRNVSDAEERLNHLLVGMDDFEQTIKYSFSDKAYLVQAFTHASYHYNCVTDCYQRLEFLGDAILDYLITRHLFDHHQDLSPGALTDLRSALVNNTIFASLAVKFGYHKYFKALSPELFHVIDNFVTFVKEKKEALGMGSQLKVLDVEGLPGHEDESEDIEVPKALGDIFESVAGAVYLDSGMSLDTVWRVYYPLMKPQIEQYAASLPISPVRELLEMEPETARFGPPERTMDGKTRVTVNVVGKGKFKGIGRNYRIAKATAARCALRHLKSQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYG2</accession>
    <name>A0A8B7YYG2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 74B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096286.1">
        <property type="nucleotide sequence ID" value="XM_022240594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYG2"/>
    <dbReference type="GeneID" id="110982284"/>
    <dbReference type="KEGG" id="aplc:110982284"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052394">
        <property type="entry name" value="LRR-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24114:SF50">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096286.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="61165" checksum="C816FD4491DFB1A1" modified="2022-01-19" version="1">MSNENEPEDQTEEEDMVVLDTDENANKTPAGSRAPSRAKSRGSIGDDRKTITRKGGRSTARPDSRLSGVDDNESQIDDSARSETTYSESSGFDTDLEVEDTILALKRNVREAYDASGKSTYKEACRLNGVIPVSYFLRHIADSELTMKHHGLGPAGAKAIAISLVTNTTICKLNLSDNWLDAVGGIAIADMLKENCYITDLDLSENKLGNSGAKALSEMLLQNSTLTHLTLTGNSFEDKSAEYFAEVILNNSKLEYVNLSHNEFSEAAGLLLGPAISENITMRQLDLSWNHIRRKGALALAKGIMNNIGLKVINISWNGFGNEGAQALGEALKVNSSLEELDITNNRISGEGAVFLGKGLTNNETLKILRIGKNPMQAAGAFAILKAVKDNTNTIMDELDFSGIQVNKEFEDLYNQLKETRPNIKIHHGGMKEAVKPKQKLNPMLKLQRYIQKNNLRLVDFFNKFDKDGSMSVTYDEFEEGLVESGIDLSKEEIAYMIGELDKDGDGEINYSSIYRSILVHDHGTRQAAMFCTGPLQAQAAAITIALTFSPTNPLFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z062</accession>
    <name>A0A8B7Z062_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/arginine repetitive matrix protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098160.1">
        <property type="nucleotide sequence ID" value="XM_022242468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z062"/>
    <dbReference type="GeneID" id="110983307"/>
    <dbReference type="KEGG" id="aplc:110983307"/>
    <dbReference type="OMA" id="ELMSEYM"/>
    <dbReference type="OrthoDB" id="71407at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022098160.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37411" checksum="9DEC831EFCBD938C" modified="2022-01-19" version="1">MAGGDDEIPPLEDMSDVLEHAKHIQSLKESSSSSTLPSGCVKTGIDAPTDVTSGNASSTSPDDASLRSSDTKETTTKASSQMAKSTSSSTGGFGGMKKGFLIGGPSKKHTSHGKSLASSSKSVPAADLKPVGGEEIPLIRPKEGSRDAREQYRIDEVQEALKTTAPLLQNKEWITEDLLSNLEKHPRLARQLTDPRFAQAVSKFQRNPQQAMEEYKGNAEVQQFFRDFCALLGNHFSTMGGASPPSVPSSAPPPQDTIRTPNQSSRADIKVKSSTNPKQATAADETEIRQILADPEIREILMDQKMQRLIETLRTNPDQGQGIIHSAGPEMQAKIHKLVNAGLLGFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0U5</accession>
    <name>A0A8B7Z0U5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097036.1">
        <property type="nucleotide sequence ID" value="XM_022241344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0U5"/>
    <dbReference type="GeneID" id="110982712"/>
    <dbReference type="KEGG" id="aplc:110982712"/>
    <dbReference type="OMA" id="RLANNCH"/>
    <dbReference type="OrthoDB" id="2668416at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="236"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097036.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="51604" checksum="8C66031C11FC2A1B" modified="2022-01-19" version="1">MAALDEPLSKKKHDQQAIQRLFLSLVPHLLEVEHQTSNASFSTDFHERNARRQRSERQIRRRLQSRVSKMRSMYIPFKLTNGLTLTAGDDLTAERRVWARERSSMWWDVVVKDHWTDQDWIENFRMTKATFTYICEKVRDKITYHNTNMRRALPVEQRLAITIWRLATNCGYRIIGDLFGVGVSTVCTIIQQTCKALASSMQQEFLVLPTKEKLQAIVDGFMNDYGFPQMGGCIGTCYIPIKRPDSNNAQEYITAEGNPAVILQGIVDNKGQFLDVSAGWPGSTSEVQILQQSHFYESVRNGTLFQASSLEIEGESVPVVLLGGVGYPLQKNLMKPFDVEGSALTDSQHVFNQQMNRGLSVAAIAFERLKRRWHVLQEKNENKVVFIPDIVATCCILHNLCEQRGEPSPIPPQEPQQGRPLILPCQESDPSAERTRHALASYFLKRLGNMQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6H8</accession>
    <name>A0A8B7Z6H8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Multiple epidermal growth factor-like domains protein 6 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110984563</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100562.1">
        <property type="nucleotide sequence ID" value="XM_022244870.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110984563"/>
    <dbReference type="KEGG" id="aplc:110984563"/>
    <dbReference type="OrthoDB" id="409374at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000002">
        <property type="entry name" value="Multiple epidermal growth factor-like domains 10"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:001129">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000041">
        <property type="entry name" value="Tyrosine protein kinase receptor tie-1, putative"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042635">
        <property type="entry name" value="MEGF10/SREC1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043:SF8">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24043">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="17">
        <location>
            <begin position="86"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="369"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="573"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="617"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1007"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1093"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1136"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1307"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1355"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1393"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1527"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="16">
        <location>
            <begin position="1530"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1118"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1161"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1332"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1375"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1418"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1547"/>
            <end position="1556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022100562.1"/>
        </source>
    </evidence>
    <sequence length="1619" mass="174062" checksum="BEDCAAB7EFE23314" modified="2022-01-19" version="1">MARSSVFYLYLAVAVVGFLGELKLVGTQYIQPQGGMNYMDQQGYQQQGYQQQQSPGRPSTGALESIPVRTSGIPMASSGNELGAGMPHVCPYQEPSMIGHRRPCVKAYTRMVKVWRPNCGYSGQWCVGYERRTAYYTSYRIVYENSYVTRYKCCHGWSRFNGEAGCMYPSCSMGVCFNGGTCQGGYSQMCLCPPGFDGPRCQYDVNECLYNNGGCQGECCNSIGSYYCKCEAGYELSPDGMTCRDIDECRIQNGGCGGTCRNNQGSFVCECPVGKRLHSDGRTCVVEDPCLVRRGGCEHECISQPNGHYTCQCYAGFRLAPNGMSCERAYSCRINNGGCQHKCMTYEDNVRCSCDTGYALMPDMKRCADKNECQLGYHSCSQLCVNTEGSFHCECRNGYELQTDSITCTEKGRVELQPVNPCENIGCQHNCTVTHSNNARCTCPIGFQLNPDRLTCSDENECSNGQSCCSQLCYNNEGGYSCGCSAGYQLNQDGCNCDDIDECVNNRGGCDQLCQNIDGSYNCFCSEGFQLEIDGRSCIRVLPPSGSVFPPVNPTRQQFLKPTVTSRCDVGAFGPGCTLVCSDCQNGALCNIKQDGCDCPPGWTGIICNETCPADTFGQGCNEVCPCINGGTCDPVNGACTCPAGVYGEYCSDGCPVGMFGDNCDRHCNCPSGVPCDRRYGSCLCPGSFGPNCNQKCPDFFYGTGCTELCDCNIHFSTGCDPLKGTCICKPGYEGARCEKECPAGLWGEQCRHVCQCRDVSSCSKITGDCFKECPAGYYGEACEHLCEYGQYGVNCKFDCRCGGNDCNKITGACFCSAGWRGVDCAEECQDGTWGVDCRENCSCPLISQLCDKTNGECLCPLGFFGANCTTRCPRGHHGLMCRHQCRCRNGGACNAETGMCTCAPGWRGPTCSEECGAGYFGKGCEERCECENNAGCDPVTGDCICTPGWAGRLCNEECPHGVYGENCENACVCMHNATCDHISGACECAPGWRGAICDKACPDGFYGYDCQRICSCSNGARCDPATGRCNCRPGYTGDYCDEECSHGEWGMDCIYTCDCENNAICDHVTGRCICANGWRGIRCDKPCSLDFYGVNCAQHCVCRNGATCHSVTGECICPSGFIGRACEFECAPGFYGPGCDQVCECLNGGFCDPMDGSCDCPSGWYGDHCEEGCMDGYWGKSCMQRCLCVNGNCDSKTGVCACMPGWRGTYCSGPCSENFYGTNCSLPCTCGEGNPCNHITGECTCPVGFSGHECSMPCPQGTWGGGCAEVCDCAENALCDSVTGECQCKPGYHGKDCTKDCHHGRYGPNCLQFCVCGNGATCDMTDGTCHCQPGWIGPTCDQACPQGYYGMFCSESCDCDNGASCDHVTGACNCLPGFAGERCERICQIGHYGPNCELIKDCHNGGVLNSTTGLCSCSLGWTGETCQEACLGGRYGPNCELECACENDGRCDRMTGCCECKDGLYGQRCEYICEPGFYGSYCSRQCECHPAAECDPVSGQCRCPPGRTGPECKQSCPLGFYGPNCLDTCDCANLTMCNPVSGRCECPPGFTGPRCEQGCQEGHYGPNCRFICACANGAACDPTTGSCNCIDQWMGPTCEQGGPLHFSVVRRGDIGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7V2</accession>
    <name>A0A8B7Z7V2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110984809</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exonuclease superfamily. TREX family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101032.1">
        <property type="nucleotide sequence ID" value="XM_022245340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7V2"/>
    <dbReference type="GeneID" id="110984809"/>
    <dbReference type="KEGG" id="aplc:110984809"/>
    <dbReference type="OMA" id="MALIRIM"/>
    <dbReference type="OrthoDB" id="10250935at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="13"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="253"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022101032.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="55560" checksum="34AEB3FC23D5A250" modified="2022-01-19" version="1">MEQTQSDPNFIKTFVFLDLETTSLLPMERPKIMEICLVAVHREALLSSSRKDLALISEQIPRVVDKLCVYPNKNVSEKSFQLTKLDNFNLAQSCKKILDVNAATMLTLFLSRQEGPVCLVAHNGDKFDFRILRTELHKLEQRLGEDILCADSLKAYAESDERTQEDRTVTVSYAMEEIYSRTFGRSVPDAHNAESDAMALIRIMVARADIMCKWMDENAIPFNDIELYYIPSPHKNSGTCLIAMSTDTRTIQTFVFFDLETTSPDPDDCKITEISLYAINRWTLEAREANSRKPPRIADKLVLCVDPEKAVSAGAADLTSLTQRLLRLNQRGAFGKGVAKLIRSFLEIQASPVCLVAHNGDRFDFPILARHFREVEVGIPEESNILCACTLRAFVKLEPELSDRKLVTLYSRYVGGVPPAAHSAEGDCLTLLHLVHHKVKSILPWIDKNAICFSEDFSAAPVYARAIRQRASATERSSSCGEMPDLKRSHTEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8B3</accession>
    <name>A0A8B7Z8B3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110984894 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984894</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101202.1">
        <property type="nucleotide sequence ID" value="XM_022245510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8B3"/>
    <dbReference type="GeneID" id="110984894"/>
    <dbReference type="KEGG" id="aplc:110984894"/>
    <dbReference type="OMA" id="IMIPRLG"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="454"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101202.1"/>
        </source>
    </evidence>
    <sequence length="953" mass="108227" checksum="F4CC0EFFBC4824B7" modified="2022-01-19" version="1">MACSSRRIVSRVNSTISGSHLLDLTDEEFDAVLQILSPRELEDAAHVLQDAINKLQHEYKRLSSVQYSDEEDNNNQFTSSEQKLAKLCLRNRKCLSRLMTVEWESEKKSESSSELSSEVSSDELTDHQDSDGSEISSECSSCLSHKRDTQTFAELESISEEVVPEGPRPTDLKSCRDFVQSLAAQVEAMQEAIRKSKDDLLSEEVPTVKQKSNYQETSSSSDTFRIGSGDYSDVPEEDPHLAEPEYMYSLNSSRLEDDGSYETPMRRMDRQVKGQNGPTTAKLRNHAHHHSQLTHSLDQSEYEEVLRVPRRHQNRPESGQNYMAVSSMYINTEVPMNNSARLDENSTNHILNSSVPTADDTAIYEFPPADDCCEADEHLDRSIRGSLSSNHHEEVIYKYDGPIIFGISDTSEVVHFEERDNVKKWDPIPIVQDLYSNIQRHQQDRESPLCRAGEVSMEGYMEKLPMGRRRASFIKKWKKRYFRSKQGNLFYYEDHKAKKSLGYIQLVGGRITEISNKCIEVTDLRGRVLLLRCSSRMEFEDWKVILNAESGVYSPTPKSPAVPTIRKHVAIIDMGGCSVRAGVLSDSDSPNPQVFFPCVVATNTKHKDRVAYGFEALTPEVRCLSKLTSPFRNPSLQEQVKVRRTKFKLSMQTVEGLLDTAFTELGIDPIAYQLMVILPFNLGPKLTEKVVEMIFDRFNPEGVFVQEQALMALYSYKATSGIVVNIGERIDVVPIVDGYIIQKGVYRLPFGGRQITEHLQRLLTEGGYRFFTEIEMYIARYLKERACFVAQDYHAEFKFCSLDPELCSTYIDVEKFDVPNGSRSVKLDYSRFRSTEGLFHPEVWGKDHPGLHTLVYNAIQACSNDIRKQMCRSVYLCGGTTLLPGLAERLRSELCRMLPKSSPVKVHASPERYHSAYNGGTVLGTLSAFDNMCITKEDWKQLGATSLTKWQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAN6</accession>
    <name>A0A8B7ZAN6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neutral cholesterol ester hydrolase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110985360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102027.1">
        <property type="nucleotide sequence ID" value="XM_022246335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAN6"/>
    <dbReference type="GeneID" id="110985360"/>
    <dbReference type="KEGG" id="aplc:110985360"/>
    <dbReference type="OMA" id="EERHHFM"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="105"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="321"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022102027.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="45970" checksum="103C990FAEF5E472" modified="2022-01-19" version="1">MVRVILAGLVVVTALVTYVIVLPVPDEVGDSPWMVKTAALKWRLQYVLKLVTPIGINEWFDERAREDSRAAGPNVPYTDAVFDRVPVRIFTDEPVGGMTAKRPAIVYFHGGGWIRGSVDGYHPVTALLARKLNLILVSVEYRLAPKYVFPTAIDDCTAATVWFLEHLNEYNVDPARVALMGDSAGGNLAAATAQRLTFDKKYRDLPKVKLQVLIYPALQAFDFKTPSYQQYGDYSTLILDTEIATWMWSLYGHGRKDLGSLVKAKMTNNHTSAAAKRSPLVQECLSHGLIPDEFKQSGYESTSHDFGDEGIFEKIKGVLLDPDYAPLMRKDLRGLPEAYILTAEYDVLRDDGIMYAKRLEKGGVPVTWKHYMKGYHGMFSLENRPLLSTTVGDKSVSDFIQFARQNLHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB74</accession>
    <name>A0A8B7ZB74_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ependymin-related protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102237.1">
        <property type="nucleotide sequence ID" value="XM_022246545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZB74"/>
    <dbReference type="GeneID" id="110985489"/>
    <dbReference type="KEGG" id="aplc:110985489"/>
    <dbReference type="OMA" id="TRANCIP"/>
    <dbReference type="OrthoDB" id="10001248at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF13">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034750952" evidence="1">
        <location>
            <begin position="20"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102237.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23508" checksum="04B222D482058214" modified="2022-01-19" version="1">MDIKPVLFLLLVAVALGEAQKKCCFPDQFEIVDGQIVGFVQSGQGTAVTQSSQAAFDYTNRRTAALLQSSGSRYQTITDYNKAVMYTINLTLKTCQKTALPSRTMDHCVPSNATYNGPFYLGDNKLTGDSFSFSLNVEGDVVNGTLSVTEGDCIPVGETLFGTFGGRQTLILAGYVNYSPGIKDPSKYFNVPSYCSTGSFSSELDEALAHVTRTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCL5</accession>
    <name>A0A8B7ZCL5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Uncharacterized protein LOC110984752</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC110984752</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRT-like transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100923.1">
        <property type="nucleotide sequence ID" value="XM_022245231.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100931.1">
        <property type="nucleotide sequence ID" value="XM_022245239.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100940.1">
        <property type="nucleotide sequence ID" value="XM_022245248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCL5"/>
    <dbReference type="GeneID" id="110984752"/>
    <dbReference type="KEGG" id="aplc:110984752"/>
    <dbReference type="OMA" id="AVWTFVY"/>
    <dbReference type="OrthoDB" id="6335830at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013936">
        <property type="entry name" value="CRT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31326">
        <property type="entry name" value="PROTEIN CLT2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31326:SF1">
        <property type="entry name" value="PROTEIN CLT2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08627">
        <property type="entry name" value="CRT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022100923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022100931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022100940.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47785" checksum="64FF6B788AEDE632" modified="2022-01-19" version="1">MEEFSDKTPLLPTPYSPTPVNDAYSGPGLEHQPISSQATDVKDFYTFNFRGGRSFTIRSQKLNVILTVLTILTNLMMFVTLPLLNNTVNKYNDYYPVLLYSSIWFQPFFFGLVFLNKYINPLAETKSSVSHKVMALLGLLNSINGVLVVYGADPRRTSGSLQALLSTASIPFTVIFRFILLRKGVGRGRLVCTGIVLIGLFIALEPEIFNIGGPTEPVAGAVTGVMKVIWPIIFLLGFLPLGILNVLIERELKKDQTESLVFLAWVQLYNGLFIALLFWTDFIPSFGAAENINEFGRNMLYALKCMYFADSTCMTAAAAYFVFIISYCLANLMVFLLVKYAEGAIWLVLVQALVTPLGSLFFTLFSVAAPPGQHGKFHWAPNFDLAVAFRFVGLFILVPTVIFYNYFGEMERRRAQQQIMAAQETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDQ9</accession>
    <name>A0A8B7ZDQ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">PWWP domain-containing protein MUM1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110985857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102970.1">
        <property type="nucleotide sequence ID" value="XM_022247278.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102971.1">
        <property type="nucleotide sequence ID" value="XM_022247279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDQ9"/>
    <dbReference type="GeneID" id="110985857"/>
    <dbReference type="KEGG" id="aplc:110985857"/>
    <dbReference type="OMA" id="TWSLEFI"/>
    <dbReference type="OrthoDB" id="10013064at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06080">
        <property type="entry name" value="PWWP_MUM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035504">
        <property type="entry name" value="MUM1-like_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040263">
        <property type="entry name" value="PWP3A_3B_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048795">
        <property type="entry name" value="PWP3A_3B_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31333:SF6">
        <property type="entry name" value="MUM1 LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31333">
        <property type="entry name" value="PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20884">
        <property type="entry name" value="MUM1-like_PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20886">
        <property type="entry name" value="PWP3A-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="124"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102971.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51846" checksum="00B00A6AA6D1A21E" modified="2022-01-19" version="1">MTRTRSSSSSTVDVSSRRLRNGTRRAQSGRISPTCTKEKTVKKQRPRAKSLQETRKNKMQVSMSELCRPENGCDAVLDNHNVISSTSLNEDLQDDDTDSLDDNDLPAIQYHSSTAATKVKELVPGTMVWAKSRGFPHWPAVLQKVFSNNKKAWVNYLDKTYQRVQVSLKSMAPFFGPSRSQYIEIGKSSKFSQEFLESMKMAEDYLIKQGLGKSAESSNQSFSLDFGKSASPTASPRKMPLSRQTSPDRSHDTESSADLPTSTNNDVSTDEEICIGHPIGSTCYDAVDKDDPALIERRKAWKCMENRLLKYIHRDTTKNHLLDIYHGKYKCERQRLFKSDRQADRLALRTMAGQGPITDEELLSELTNFLRDLYVENCMECKEDIPNASYITEVWLPEAIIFAIQKTRRVVRHTAEELFHSEGVQSLIDLGDDMPAASSTVSTSWDKALPSSTNNNRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEG1</accession>
    <name>A0A8B7ZEG1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Coactosin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110986080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with 5-lipoxygenase (ALOX5/5LO) in a calcium-independent manner. Binds to F-actin with a stoichiometry of 1:2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103387.1">
        <property type="nucleotide sequence ID" value="XM_022247695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEG1"/>
    <dbReference type="GeneID" id="110986080"/>
    <dbReference type="KEGG" id="aplc:110986080"/>
    <dbReference type="OMA" id="ICEAYND"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF29">
        <property type="entry name" value="COACTOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="9">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022103387.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16620" checksum="E77DC1C4F6ADD07C" modified="2022-01-19" version="1">MAKPFTPEAREKLYEAYQDVRDDKSETRWCVAGYPDNGKLIDITATGVDYQEFLELMQDDERIYGFVRYETGDEMSKRAKFAFITWIGPAVSSLQRARVSTDKAFIKDIFTNFGVEVLADDRHDLQEDGVKDRLVKAGGANYGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEP0</accession>
    <name>A0A8B7ZEP0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="19">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110986123</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18 19">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="19"/>
    <dbReference type="RefSeq" id="XP_022103457.1">
        <property type="nucleotide sequence ID" value="XM_022247765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEP0"/>
    <dbReference type="GeneID" id="110986123"/>
    <dbReference type="KEGG" id="aplc:110986123"/>
    <dbReference type="CTD" id="56270"/>
    <dbReference type="OMA" id="WYGQSNT"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002253">
        <property type="entry name" value="Flavin_mOase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01121">
        <property type="entry name" value="FMOXYGENASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18 19" id="KW-0274">FAD</keyword>
    <keyword evidence="4 18 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18 19" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 18" id="KW-0521">NADP</keyword>
    <keyword evidence="10 18 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022103457.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="60406" checksum="90CD616CA22B0E19" modified="2022-01-19" version="1">MQEKTVARSVAIIGSGVTGLAAIKCCLDEGLQPTCFEKSDTIGGLWVYRDGTDFQMTGSVFKSSVTNTSKEAMCFSDFPFPKQWPNFLRNADMKKYCDLYAEKFGLTEHIRLSTRVTCLSQAPDYNTTGRWVVTSRQQESGDGVTSQVFDSVMICTGMFNNPFRPNFPGLSDFQGRVMHSHDYRKPVGFDDKRVVIIGFGNSAIDAAVDLSRCASQVFLSKRRGAWLVSRRADNGYPYDLMHLRRYRLILSELREMSFKKMLRSRYELINHALQPAGNFRRCNNRVINEELPGSILNGSVVIKAAPEHFTKTGLVFKDGSFEDDIDVVIIATGYSFTLPFKVDCPALETDPRLGRLPLYKLLFPLGLAHNTLSVNGAFELLGPVIPCVELQARWASRVFKGLAKLPPQSEMAAVALETVNGFDVPCVRYVTHVGYADSIASEIGVRPSPFKLFFQDPELALRCMFGPHVPYQYRLVGPGRWAGAREAIKTVWERVLAPTKTRHEDPRERSLSTISALLGIFTLMLVQSLLLIYNFICSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZG15</accession>
    <name>A0A8B7ZG15_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110986398</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110986398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103937.1">
        <property type="nucleotide sequence ID" value="XM_022248245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZG15"/>
    <dbReference type="GeneID" id="110986398"/>
    <dbReference type="KEGG" id="aplc:110986398"/>
    <dbReference type="OMA" id="QLSHCNA"/>
    <dbReference type="OrthoDB" id="10115181at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000100">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034366115" evidence="7">
        <location>
            <begin position="24"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="9">
        <location>
            <begin position="128"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="9">
        <location>
            <begin position="348"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="9">
        <location>
            <begin position="573"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022103937.1"/>
        </source>
    </evidence>
    <sequence length="784" mass="90313" checksum="8B393D02A1CD28FF" modified="2022-01-19" version="1">MRPLARWSLVAVSLVALLGVVRAEKVCYFSQEPDRRQNGRLRWVLPGSKSDHCRCTSIWPGPLYTKPLQRSQEPFYTDTPIFTSDQEEIHHFFECHDPCSPNPCQNGGTCSQYGESFLCQCAPGFEGNNCDNKPLDCAALHSHGIRQSGVYTIYPSMYPDGLEVYCDMKPGYPYGWIVFQRRLDGSVNFTHNWSQYMDGFGNLTGEFWLGNEKLRQLTSKHKWLLQINLTFDDQINGANFISYRWPFRIEGDNYTLLEGSIGRSPLPLSQTPRPFSTYDKDNDGEDHLNCAALTRGGWWFDQCESPQDSWGNLNGEYFLPENSTDGNYFGIRWPEGESFAVVRSSEMKLRRFHPYDCLSLFNIGITTSGVYTIYSSQYSGSLEVYCDMDAKDGGWNVFQRRFNGSVNFNRNWAEYRDGFGDLTGEFWLGNEKLRQLTSVNEWLLQIDLTFDHQIHKTYRWLFRVEGDNYALFINGSTGDSPLPSSQTPRPFSTYDKDNDGEDHLNCAALTRGGWWFGQCESPQDSWSNLNGEYFLPENSTNSTDLEYRGIRWVDGRNVSVVLGVEMKLHRFRPYDCYTLYNHGIRQSGVYTIYPRKYPDGLEVYCDMDATLGGWTLFQRRFNGSVNFTRNWTEYQDGFGDLTGEFWLGNEKLRQLTSDWRWRLQIDLKDHTGKHKTFHAEHFRIEGNDYKLTFDESVRSNPLPPHLSGRSFSTYDMDNDEDTNANCAAELKGGWWLDTCNGTSGAPYGLNGEYQQGPNDRGITSDGWAGHRIVKSEMKLRRSWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZG59</accession>
    <name>A0A8B7ZG59_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Proteoglycan 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110986353</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103848.1">
        <property type="nucleotide sequence ID" value="XM_022248156.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103849.1">
        <property type="nucleotide sequence ID" value="XM_022248157.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103850.1">
        <property type="nucleotide sequence ID" value="XM_022248158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZG59"/>
    <dbReference type="GeneID" id="110986353"/>
    <dbReference type="KEGG" id="aplc:110986353"/>
    <dbReference type="OMA" id="FMDERES"/>
    <dbReference type="OrthoDB" id="10021598at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696">
        <property type="entry name" value="AGAP012002-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36696:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="627"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022103848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022103849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022103850.1"/>
        </source>
    </evidence>
    <sequence length="749" mass="85053" checksum="53DF25534C1EDA49" modified="2022-01-19" version="1">MLDPSLPWLAVGYRNFKQEDFCQRQIRDEMSKYRVDATDVRSMLRSSTPQGQQRRRVKSATTARFASRSVDSLFNRPVPARPKSAQLFHRSYSHHQDVERSPASRQPPRPRSAILPHHRPSAAQNRSVTAVERQHHAEQTIKLFMDERESRCAFCPVECRPKSSSSNRPTSSTGLVAAHVPSHYDRYIFWTRPRTAPATKKEFLQLPRHNNIRRGTVPHYTNFVKRVELGLRDRTPSPPPRRRIAFEDESGKRHSPSLESSSSADEEEGELVLSEEEDDEDEIEEDVSIRIPTPIEPPPDDGPEEPPSEEGREAWTQPKAPTPSPALSGRNSPELDVPETSPVDEPEEPPPPREQSPPPRDPTPPLREPTPPPSESTPPPREPTPPPREPTPPPREPTPPPEPKPKKEVRIQETPVPPPAKPKTVPQTPEKKTKSCLAKKPEVPKDVQPQPKPPTPEPAPKVVEEVATQMEDKRTEIPPLATEEESTEDAQTVQDAAQEEPGEPEPEQTGDLEKLAPETEDKLEKKKLGPPPKYKVDLFGVDSQAMKDLLDMEMRMRRKGPGSHVSDTESAPPDIPEHLLRRRQPWQQGRLALSRRACRFELPMDVHLLENMSPTEYLQKYCIVSKRRQAMYRRAFSKVDRSNSMKINKKEFNIAVLEALVDTVNTDQIQDALQLLEADNFTQFGPKLFCAICSLLERLHYSDYVTEDTIDQESLVAKERVEDADFLALDWKLDGCVINPSLKRLLYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIZ9</accession>
    <name>A0A8B7ZIZ9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110987309</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022105613.1">
        <property type="nucleotide sequence ID" value="XM_022249921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIZ9"/>
    <dbReference type="GeneID" id="110987309"/>
    <dbReference type="KEGG" id="aplc:110987309"/>
    <dbReference type="OMA" id="RATYERP"/>
    <dbReference type="OrthoDB" id="10040011at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000127">
        <property type="entry name" value="Thyroglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034716049" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="28"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022105613.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="67330" checksum="9616B91A0CEE8001" modified="2022-01-19" version="1">MAALNLVVLITNVVTLGAFTAPSAAQNQPTVTVQQGILVGTTETFQESLFINVNKTIDVFKGIPFAEPPVGQLRFRPPVAKGPWDGTYDATYFRDACVQDPSDVAGAPVSEDCLHLNIFAPKPAVPGGAAVMVWIHGGGFVQGSGVESIYRGQALAALGDVIVVTINYRLNVFGFLTTDDEALPGNIGLMDQAHALEWIKENIDAFGGNNSSITIFGESAGSASVGSHLLSERSQGLFNRAIMESGTLMSPWAFSDDKDMLRKQAFDIGKRLGCSNSESEALVKCLRDKDARDLYEAADALNFLGPVVVDGTFLVDTPINLYATGRYNHVDLLIGTNRDEGTMFLLISPRFIDYLNSKNPPKVSRREFDELLASDIYLGASPQIQDAIRMQYIDWSQADYDDHDYFRSYVDFGTDYHFACGTDQVARFHFQGGDNVFLYQMTHVPSVSLFNLGGGGPGWFGCGHAEDISFVFGLPFLPETAALYSNFTDEERALSVEFMKFWTTFAKTGIPNKNAQGSNSSSQRDFWPRFTVPELEYKVLNLNLTTSRALKSDYCHFWNTYVPQLQTMLADMDVAEREWRQAFSTWKYTDMADWRKEFSEYKTVNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJQ5</accession>
    <name>A0A8B7ZJQ5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Asparagine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110987438</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022105863.1">
        <property type="nucleotide sequence ID" value="XM_022250171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJQ5"/>
    <dbReference type="GeneID" id="110987438"/>
    <dbReference type="KEGG" id="aplc:110987438"/>
    <dbReference type="CTD" id="4677"/>
    <dbReference type="OMA" id="DCCLYPR"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000151">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000040">
        <property type="entry name" value="Asparagine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="279"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022105863.1"/>
        </source>
    </evidence>
    <sequence length="581" mass="66780" checksum="980F80DEA6F6B61A" modified="2022-01-19" version="1">MLSRAAVLLTTKRGVVWNSLLTKYLSSGKMAGLGAKMERLYISEKGDDETGDGTEQKPLKTLLKAMHISGGEPFPQFLSDAKDKDKQWEEVSQAQRKKAFKVFQRDQKKNEEKERREAEDRERREKNLEEAKKITISEDPSLPAAKRILIKDGTTNRDQRVKVQGWVHRLRRQGKNLMFIVLRDGTSFLQCVLNDKLCQTYNALILSTESTVALYGVIKVLPEGKTAPGGHELSCDYWELIGAAPAGGADNLVNEESHIDVQLDQRHMMMRGDTLSKIMKVRSTVSQCFRDHYFSHGYHEVCPPTMVQTQVEGGSTLFKFDFFGEQAYLTQSSQLYLETALPSLGDVFCISQSYRAELSRTRRHLAEYTHIEAECPFISFDDLLNRVEDLICDTVERALASPIGPLIMEFNPDFKPPKRPFRRMDYSEAITYLKEHDIRKDDGTLYEFGEDIPEAPERKMTDQLNEPILLCRFPAEIKSFYMQRCPEDRRLTESVDVLMPNVGEIVGGSMRIWDYEELLAAYKSAGIDPTPYYWYTDQRKYGTCPHGGYGLGLERFLTWILNRQHIRDVCFYPRFIERCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJY5</accession>
    <name>A0A8B7ZJY5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM185A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105342.1">
        <property type="nucleotide sequence ID" value="XM_022249650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJY5"/>
    <dbReference type="GeneID" id="110987167"/>
    <dbReference type="KEGG" id="aplc:110987167"/>
    <dbReference type="CTD" id="222234"/>
    <dbReference type="OMA" id="HEYPAAD"/>
    <dbReference type="OrthoDB" id="5984441at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="Toastrack_DUF4097"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34094:SF1">
        <property type="entry name" value="PROTEIN FAM185A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="292"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022105342.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="51379" checksum="BFB2913E09250BD9" modified="2022-01-19" version="1">MLLFARSSFQSLIIRGIHNLTFQKRLLVPNKIMFSAVFEVRSCHFPSNTAALGLMQGGGYDGYTILRTKSIPCTGARLASTADTENPARSRVDDEQPTGETISDFHLVKLRSWAFTVEPFGCVSLDTSLSARVTPTNPHDYPAADRAFVHLLLHTRNPWKPGDELDRMLKEGDADSLLERYVQCSVQYQDGVIHVTGDAVEKVGDSGMTNEEADQNDYLWLVEIPMSYDVNAVTTNEASVTIEQLENQSCDVQTDKGDIVTKKLKSDAVSLRSTCGDVNCLKMLQGNISIATGDSGTVTSDRLQGQDISVSAGSGSVLVKDVYARKSSFRSLSGTVNLGNLHGDVTVACKEGNVKIGSIDGSLKADVDRGDVSVYLAQHKDVDIVCRQGDISIKTSSDVHSKFHLQASEKIELSKELTANFTPEVEDGHAKLDTRTKRGASNGGQDSSLTAVTQHGTITLSVQSWLDSLQLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKL0</accession>
    <name>A0A8B7ZKL0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein starmaker-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105577.1">
        <property type="nucleotide sequence ID" value="XM_022249885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKL0"/>
    <dbReference type="GeneID" id="110987288"/>
    <dbReference type="KEGG" id="aplc:110987288"/>
    <dbReference type="OMA" id="KRMWHRQ"/>
    <dbReference type="OrthoDB" id="9950633at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026703">
        <property type="entry name" value="ERICH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21520">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21520:SF2">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105577.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="52199" checksum="8A3D2F24CBBBBD37" modified="2022-01-19" version="1">MSDLHEEMQNQNNNVMISRQSGSRSGTPNSMMVLEQGHKSPSRPPSGRRSVNRQSPLKRGGSSLEILPSQEEERSGTSSRLSNDGVNVDSSRQTQSAGAISRLSFTEDELGNGDGRGGGVELKRSSSIDGRAELKTPDSPRKQVYLTTVKRNFEQHGMPKNEELAKAVQNLPSLQNGVVGDPPSSLHTTRDSSHRKEQRERPSHHETGTDNNELKNPGEIETTVERLTLEEGEGQRSNDRGHSDEMKDTDSYYISHGTISNKSKAYPASAAASISSTAGSDSYYLTHDRASSSTSFDTRQSSREAEEPQEEQVVGATSTSDVSAGVEGDHDDSSDDDDDDDDDEEEEGKAPFQLLGEFLEAVMEEDYENAEKLCKMVLLYEPDNTEAKQFQPLIEEMLKREREEQLWGSESDDGDDEDDDEDDEEDEDDEESDEDDDEDEESDKDDDDDEDSSEEEEETDEDKSEAQVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKR0</accession>
    <name>A0A8B7ZKR0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Ras-related protein Rab-35</fullName>
            <ecNumber evidence="8">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC110987562</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Melanosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022106074.1">
        <property type="nucleotide sequence ID" value="XM_022250382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKR0"/>
    <dbReference type="GeneID" id="110987562"/>
    <dbReference type="KEGG" id="aplc:110987562"/>
    <dbReference type="OMA" id="HEIDTNC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000404">
        <property type="entry name" value="Putative ras-related protein Rab-35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0168">Coated pit</keyword>
    <keyword evidence="23" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0636">Prenylation</keyword>
    <keyword evidence="17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022106074.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="22952" checksum="2B377F35D895AB90" modified="2022-01-19" version="1">MAKEYDHLFKLLIIGDSGVGKSSLLLRFADNTFSGTYITTIGVDFKIRTIDLNGERVKLQIWDTAGQERFRTITSTYYRGTHGVIVVYDVTSADSFVNVKRWLHEIEQNCDVVSRILVGNKNDCPEKKVVLTEDATNFAEQMGIQLFETSAKENINVEEMFNAITELVLKQKKENAAKQTAQENSQTVRLGSRKGNKSKSGCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMY5</accession>
    <name>A0A8B7ZMY5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987939</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106794.1">
        <property type="nucleotide sequence ID" value="XM_022251102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMY5"/>
    <dbReference type="GeneID" id="110987939"/>
    <dbReference type="KEGG" id="aplc:110987939"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034220400" evidence="1">
        <location>
            <begin position="35"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106794.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14982" checksum="732A1FA969E45428" modified="2022-01-19" version="1">MARRYPLSAKIPCLRTLTSVAAVLLLVSLHSGAAEISEELITRWKDASRRQEEHNADFDEQEMGIVTMNLEIEYSTASKKGVAPEGRKVSCLNKHISEDDGEIHIVGFKPESRDRSVDKIILYGCPQLATGQSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZN42</accession>
    <name>A0A8B7ZN42_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein diaphanous homolog 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110987750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106472.1">
        <property type="nucleotide sequence ID" value="XM_022250780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZN42"/>
    <dbReference type="GeneID" id="110987750"/>
    <dbReference type="KEGG" id="aplc:110987750"/>
    <dbReference type="OMA" id="EWLECIL"/>
    <dbReference type="OrthoDB" id="410721at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF10">
        <property type="entry name" value="FH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="35"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="362"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="835"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022106472.1"/>
        </source>
    </evidence>
    <sequence length="947" mass="107822" checksum="BF5D0D4BB4625E04" modified="2022-01-19" version="1">MCRLLCLIVENNKSSAKGRVLTQADLRGTLRRCQQVIKEGFLEKKNHNLYTTYTRRWIRIREGELSYYKPDDDNQQALNILQLSDDVTIVKKLNFNGFSIATRKKVYFFRIIPSANVSAADIEKERDEWFKAIRFACGDRRDSVAIFVTDETLHKNSLAASAESKPTSESFYQAMRHFQEELERLSLVINSLDERGDATKALLQLQQKAKVIETMFSQIRPSSDTSCSGISTSVDTETSSHLDQASTVTLETGEQSYDEPLPLLIKSDRHSLIISNNWVLHNGCSAGLMNGNSVIVDPSEPNSENHSGNDTHSTDSLEQRTDMIVNGITSCSSSSLSAVFESFIPPPPAPPPPPEMVAPITRKFEVTSKVKMRPFHWNKVSALMIKKSIWQNARDLTGKVDTEFLQQMYSQKSEHNIPEAVEKVETSKRKLKTFLDPKVAQNLGIFLAGFKMDAEELKFRLAILSEKDGGLSAEQINMLRRYYPTAEDMETYKKFKERQAELENADQFMLQLCEIPHLKTKLDVLMVVNELPVQYEDLAPTIDKVHDASKLLCTSEKFVSILEHVLAVGNFINSGSAQGVSMGFRLTSLPKLADCRGRDKTCTLLKYVVQQIYKESPELLTFVDEFTPMTQLFDVSVKALEAEVEVMKRDLNNIKKNMTILAKVENPSERDVSFFDDVAAFVEQYELKVTSLQKKSEAMKFLYEQMLERFAEPRGIDSSDIFTAIGNFVKSFKREMDLILAASGLGRRMSKMKVNQSYLKKDDKAHIERGAQFSSCNGDTEKKINGEPIDDSPSNHVAALRKAFSSGDNKPYSKQGRELLKAFQNKKQERRHIWNPTKEGYLEKLSNTKSPLTSSWNRRFFELTAKGHLYYSKRKNEKNVESIYLRGVPVALEDDKTLILQTEERCYKLRANSHKEAQEWLECILFYTHKPASFPKRSLTPKSFEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQM8</accession>
    <name>A0A8B7ZQM8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Macrophage colony-stimulating factor 1 receptor-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110988190</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107185.1">
        <property type="nucleotide sequence ID" value="XM_022251493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQM8"/>
    <dbReference type="GeneID" id="110988190"/>
    <dbReference type="KEGG" id="aplc:110988190"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034595265" evidence="16">
        <location>
            <begin position="22"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="17">
        <location>
            <begin position="16"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="19">
        <location>
            <begin position="140"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="322"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="419"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="516"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="630"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="725"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="923"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022107185.1"/>
        </source>
    </evidence>
    <sequence length="1231" mass="134217" checksum="F20DAEC288A7FCF6" modified="2022-01-19" version="1">MGTHLFAIVVSLAVSVRGILSSNVTLGPYETARITSPSYPNNYGNNLNIIWVIQTVEHWRIHVIASSFNTESSYDPLRGGDGTDSANSTTAIFVSSGSRGPDAVSNGPVMWLRFTSDYIISSSGFILWAVSVPSQSSLDFNCTFEDGLCGWTQSTDDDSNWTLDSGGTPSSDTGPSIDKTIGSTIGTYCYYEATGRSEGDRAVLVSPVVARDIGRSPSNFCFSFWYSMYGLSMGTLNVYGVPINGSIDDGEVVFTRSGQQTTSSRTWLFQSICLSGPAPRFKVAFEAVRGSGYTSDIAIDDLVASVFSSVTVLFWDSTTIFPPVGGISHIVEGEDQSFLCQVVDLQQGASFRWTVDYQEVTPDRSSSLRDNSGLYTSTSVLTLPVITSARHGKVVQCHAQPTNQYPLSTVATIYVKVPPKQSNLSLYDSDGILGVSVSVVEGAPKAFFCTVKLTRPAATIQWLLNEANQMTDTPPSGGSDGLMDTTSSWTLVPSRANHGQRVKCVASTPESESPLPSVTVTLDVEGPPDTPSITGSQEMTENELAQLVCQADLGYPNDWGLVWSTGGLPAQGSLTTAVTTSGNRFKFTSTLNFQPARTNNGDMITCSVARGSLTQGLTETFGPINVKYPPYFSDLETPRTVSEGDDVMFTCRADANPKPARFITWEKVGSPNTLSSVYSNGSSSLALLNISREQAGRYRCRGDNGVPPVVYSSQINVTVRFKPRPPMDILIQQGGLTSDSLTIAWTPTNDGGEEQWFYVNHRELESTADFDPATRSIRLYNVSMFTVVGLHPDTAYEVEVYAENANGVSGAVKTVGTTKRSSLAHLGYIAGMSVEALILLLSIITNLVLCWKWRITTKQEKQQRASESRRAKTGASPRVVEVTEDYEIMSIPMRTIQAKTAAVAESTYDNIAESQVTISRDQLTFVRELRQGAFRKLLLAKAEGIELPGVATPVVVKTTQDENDPSEKESLMQELMSMKALTSHANIARLLGYCVDKDPVYVIVENVAHGTLKELLTEYADQSEQVYDNLGGAANIPLTPRTLLSMAKDVAEGMAFLASNTCLHKDLESCNVFVGEEMVCKLLDFGYAKDVAHLRKHQHQNQGLVPLRWMALESVLDDVYTTKSDVWSFGILLWEMITLGARPYPALNAKKVVTKVKSGYRMPHPSHCHVQLYQLMLECWAKNPEARPTFATVSETLEGLMGKANEYIAFESYQAHLFKTAVSGGSDYEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQQ4</accession>
    <name>A0A8B7ZQQ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hyalin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110988491</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107734.1">
        <property type="nucleotide sequence ID" value="XM_022252042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQQ4"/>
    <dbReference type="GeneID" id="110988491"/>
    <dbReference type="KEGG" id="aplc:110988491"/>
    <dbReference type="OMA" id="CPDDVFK"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="59"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="146"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="233"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="318"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="481"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022107734.1"/>
        </source>
    </evidence>
    <sequence length="595" mass="62312" checksum="D75B8CEC953793C8" modified="2022-01-19" version="1">MWNPSLCRFGQQITNVAQSHQLGQVFNIGRTVVTYLFTASSGSQGVCQFTVTVNAGLPIDNTPPTFVVGCPSEVTVSAPSGSTTFVVNWDPPVATDNSGTVDTFASHNPGSTFFVGVPTTVTYRFTDPSGNSLTCSFTVLVNVGTVDNTPPTITGCPSGVSVMTAPGATTATASWQPPVGQDNSGVAPQVFNSHSPGDTFGVGNTQVFYRFVDGSGNEATCLFLVTVSTSGGVDTINPVLTGCPTGVTAYVSAAVTSVRVTWTEPTATDNSGVVPMLASNPSVNSIFPLGLTTVTYTATDGAGNRATCAFVVNVIVDLTAPVISGCPISAVRGTLSAGQATTSLTWTEPTATDNSQLPVTRNRTHVPGQAFPIGTTNVIYTFSDSVNNEAICTFMVIVSSSTPSNPCSSNPCPSGQLCFYTADAYLCRPGAGRKRRDALPDDNRYCPCENGGECVHVESEPPASYCICPMGFRGVLCEKAVINECNPNPCANNGTCTVTIGSDPSASYHYSCLCSEGWTGPNCLNAVNDELVIHTGDLTDLTDHRRGLMETEWLLGSLIAVIIILFLVFAVTVIRITRRTVLPTSKADDEVAIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQU7</accession>
    <name>A0A8B7ZQU7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Microfibril-associated glycoprotein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110988349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107442.1">
        <property type="nucleotide sequence ID" value="XM_022251750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQU7"/>
    <dbReference type="GeneID" id="110988349"/>
    <dbReference type="KEGG" id="aplc:110988349"/>
    <dbReference type="OMA" id="LENTTHR"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034336223" evidence="3">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="122"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022107442.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37496" checksum="DE60D42120C8A246" modified="2022-01-19" version="1">MAQVQQIAFLVYLVLGLCTCTTVINYTIPGNGAQPVCEQHIIINPLDGPSCSGTACNYSTIQEIVSGELENTTHRLAQLETHIASKADVMTLSTELTDVKLQLEKIKESVSELAELLKNATVSTPTPPKYCSEAFASGVYTVQPADDGAPVSVYCDMETDGGEWTVFQRRQDGSVDFYRDWESYRQGFGDLNGEFWLGNDNLHRLTAQGVYRLRIDFEDFEGNIAYAEYNRFRVADASDNYRLMVVGYSGTAGDSLSRHSNLPFTTRDSDNDSIDSNCAIAYSGAWWYADCHSSNLNGQYLGGQTDVYAKGVIWRDWRGYYYSLKRTEMKMKVTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZR01</accession>
    <name>A0A8B7ZR01_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110988265 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107305.1">
        <property type="nucleotide sequence ID" value="XM_022251613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZR01"/>
    <dbReference type="GeneID" id="110988265"/>
    <dbReference type="KEGG" id="aplc:110988265"/>
    <dbReference type="OMA" id="VHGVWSC"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="7">
        <location>
            <begin position="205"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022107305.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="41402" checksum="BA88407ADB462B43" modified="2022-01-19" version="1">MKCIRVIAPGEPLVFLEDEPIPKAPDGGAVVKISYSGVCHSDIHFWEGRRDMGGGKIVTFLGRPGFNYPCIPGHEIAGVLSSLGEGVTDISRNGLKLGDRVVVFPWIFCNACGFCKADYNVLCDGPPTQQVFYGTTYNGGLAQYVSVPNIRYVVPLSASIPLPVACLLPCSGLTAFHVIEEALEFVKTVTKVKGCCSVMAIGVGGVGQWGVRLARALFPPETQIICADVKQEALDVVTSNVRDTVPLLMDRDQPSDSIARQVKTVSRSGRGVDVILDFVGATKTFEIGKLSMQMCGQYIVTGLLGGEVRMPLPDVVLTGVTIKGILMGRLTQLKTLLELVVKMPSIYDNLTYSVHPLEDGVQIMEKLAKGQVVGRAILKCNDDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRH1</accession>
    <name>A0A8B7ZRH1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NEK6-subfamily protein kinase</fullName>
            <ecNumber evidence="12">2.7.11.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110987542</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.34" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022106036.1">
        <property type="nucleotide sequence ID" value="XM_022250344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRH1"/>
    <dbReference type="GeneID" id="110987542"/>
    <dbReference type="KEGG" id="aplc:110987542"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08224">
        <property type="entry name" value="STKc_Nek6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000148">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000204">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000240">
        <property type="entry name" value="Serine/threonine-protein kinase Nek7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEKL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022106036.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38537" checksum="ACE5D7C5FCAF18CA" modified="2022-01-19" version="1">MEQPMDQGMEEGSNNDMYNTLANFSIEKKIGKGQFSVVYKAKCLVDNRNVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIMYLASFIENNELNIVLELADAGDLSKMIKHFKKQKRLIPERTIWKYFVQLCSALAHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHETGYNFKSDIWSIGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDIYSHEMAALDSPFYSEGLDLWTLCEKIDKCEYPPLPSYFSNCVSIVSSANAGPTWIVRHNVGAYGEEVEFLNDDGIPYCLVINEKLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTP9</accession>
    <name>A0A8B7ZTP9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein LOC110989112 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110989112</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108948.1">
        <property type="nucleotide sequence ID" value="XM_022253256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989112"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034258886" evidence="13">
        <location>
            <begin position="28"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1844"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="17">
        <location>
            <begin position="264"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="15">
        <location>
            <begin position="357"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="18">
        <location>
            <begin position="782"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="16">
        <location>
            <begin position="938"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="19">
        <location>
            <begin position="1101"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1468"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1793"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1876"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1503"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1802"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1821"/>
            <end position="1830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022108948.1"/>
        </source>
    </evidence>
    <sequence length="1926" mass="211624" checksum="B5C7A6AB7C18F4DE" modified="2022-01-19" version="1">MHRRVGLFSQLLFLALMWAYTIRTAQSQTTAEFTANTNAFITQFVTSESLTNDGTSVYETTAVGGTAVPTGQSMITTTTSEAFLQTEGTSQQNNHVFLRSPIWPLELKTIRLHPSTCALFSSVPEATTDDTIGKITTSMSFTEGITHTKETTKGFTDSSSTKPMIATAVTEIFTNIPGVKSTENGPMPTVSPTSSYGENQTEDSKSTEQSGFAPSTMSSTSSNGANPTEAESTCRPGDFDCGESVCISGLWQCDGFPDCDDRSDEEGCVGCRNFCFKDGPRGGCWCDGACEVYGDCCADYYEYCTIPDYPTESPDVDECDPREPLHDCDENAFCIDTIKGFNCTCKEGYEGDGKSCADVASPNISCPNDVTVYTNCHKSYSTVSLPDVKSAYDNSGTYSVSVDIKDSSYQVGDNVTFDLASSPHQVRYTATDESSNNATCDVLVSVSSVNDGEKCSATGSPPNCICSSNQQGYCTCSSGYCGHDCSQGDVGTQCTRPGEPFQNCKGIDECSPGYTGPQCKEVSAGTNCPEVANRCLYRGVTSVKVTWTQVKAVKPSGDPISPADITCKDIDGASVDLTGGDFGLGKHEVVCSSDTENGVVPQCLISFSVSAFPSLGVPHLGEQCTDSGETTSTVAWNVQPTTPGDDLIITCTGDGTNIGPSGGVFGVGSHVVTCTATNSGGCARSKAFGFNVVAGNLLPFGVEVGDSLLSNAKQENQQSKKDLISPTIFPPNFFPYCKELYEKIYFTDNGAIVLSNDKSVSKWAYPGAKSLKFPDGIKMIAPFWADVNADAFSAKKNVFWQVYDQYDANTDQDMLDTIKAIVLPDAGSDEGLAYWALVITWSNVQPDAKATGTNTFQVVLLTDSIHSYGMFNYDPCKMNWDTAFLPNKNVILGYTCGVSDQSVHVDVPEHLLFRPGGIVGNSGQRGRWVFQLDSHSKEFVNPRLSCHNWYSRQAPYPIFDVYYPPFADTCPCSLRMAWFDWRFRSTWWHRYYIPRGDVWDYFQDSSVVCYVRFYQAPGTPGPQCCYKRSTGDLLYDVRNPQVATVFERFPFSWIFYTPDVFQQWYEEDVLSRYHCCEKSTLCHLYTEWRPLMTCSHYLPAFWGWFWGDPHVRTLDGLDYTFNGLGEYTMVLIEDLERGKQIFELQGRTQRVYDPKTEELTEATSYSGFSALDFAGGAKVEIKLNDEATDLITTVNGSVVEPTTDGLVFDGLTVRREQDPPKVVAIFSIDVQFAVGVNNSFVDITVQLSQKYNGSTKGLLGVWDGNRTNDILRRNGTFQEPSGTDGKMLEKDYFDFGETWRVSKEDSHFYYIPPEESWDKINDLSFRPKFLEDLLDSIDDEQRQKLEEVCGDSRQCLYDSLVMNDTTIGQTTKELNERNNEDLESATNYPPKFTLVETVRATVEEKLTLQLDATDPDGDDVAFQLMESIQGATIGEEDGLFIWIPVDTSKVRVGFLATDGRSNSTLEPIVNLCNCQNGGTCLSDQFVDGTNLIQDRFGVLLCQCKPGWTGEFCEVNYDACAGSPCYLGVECTDEAPPSMNSTCGPCPGGLEGDGKTCTDIDECKMYKDDPRLRCDHNCENFPQSFKCSCETGYYLDDDGKTCLEMKDSDCFNGAEFDQNTHECVCPEEFSGLTCAEKNPCWLNSSLCSETGTYCVPDTKEEGFSCVCRAFEGYVEIGDGSCEQIPSFGVEIKTNLDFKAAYKNPTTSAFKDTAAMLERAIMNRLETDKATWNALAVQVTMMERGSVVVTFVVSFPENEVPTKVELEEVLSSSQTLFDGNTTVGIDPDSIRTEEVQTTCPVHHCLNGGTCERPNLSPWFSCRCVSGYTGEQCEIQPVPNQGGLSTVALVLIILGSLCLVLVVVVILVVLVVRKKSKVDPSLGSSRRPSEDDDNHTLVPVEEGENMRLTENTNPAPVTKMDMPSTETEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTZ6</accession>
    <name>A0A8B7ZTZ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Integral membrane protein GPR137B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988907</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108552.1">
        <property type="nucleotide sequence ID" value="XM_022252860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTZ6"/>
    <dbReference type="GeneID" id="110988907"/>
    <dbReference type="KEGG" id="aplc:110988907"/>
    <dbReference type="OrthoDB" id="192544at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21464">
        <property type="entry name" value="7tm_GPR137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029723">
        <property type="entry name" value="GPR137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15146:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022108552.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47185" checksum="4B9845B0764A5FAA" modified="2022-01-19" version="1">MEEIDHVSWTSLGKAVAPSPIGTAFPMTVELGLTISFITLYGFIFGLVYIQLILILYYGHKRLSFQTVFLFLCLIWAGVRVTLFTFYINNTIQVDDLQIFGYWFFFCFPVCLQFITLCLLVLYFAQVLFKLKARTKPENYKRHIRHVRITFVVMVTIFLVMNITCAVLTRLYSNSPVLVPIRVSISGLLFILAGVVLAYLIWKLSRMQFVGSMLLEARGATLFQTSTACVFIILLYVSRAVYNIIAITRTCPSFGYNWINVSDQADMINTLKGLRYLSFGIILFIWEFLPTFIVVMFFRVRKFAANVQHVPKDPDCPKTPSRAYFFDNPRRYDSDDDLTRTHSSTNATPRDYQGENMSIPSTPINGTPHVGYGTIVRSSSYPTGYGVPGMTPPMLFAGIPGNISIRGYHENEAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVA5</accession>
    <name>A0A8B7ZVA5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110989422</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 18"/>
    <dbReference type="RefSeq" id="XP_022109488.1">
        <property type="nucleotide sequence ID" value="XM_022253796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVA5"/>
    <dbReference type="GeneID" id="110989422"/>
    <dbReference type="KEGG" id="aplc:110989422"/>
    <dbReference type="CTD" id="10423"/>
    <dbReference type="OMA" id="AQTYSEN"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022109488.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24715" checksum="C131627AE730DB72" modified="2022-01-19" version="1">MAENIFLFVPNLIGYGRIVLALISFYYMRTDYVTTTWCYLLSGLLDAFDGHAARMLNQGTKFGAMLDQLTDRCATMCLLVALSVLYPDYMFWFQLSMSIDIASHWLHLHSSSVKGIANHKLIDMSGNPILRIYYTSRPVLFTMCAGNELFYSMLYLLYFTEGPLIPIVSVSIFRLILLISAPVALAKTAISLVHLVTASRNMAIIDVNEREQKATSQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWY0</accession>
    <name>A0A8B7ZWY0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein scribble homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110989494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109602.1">
        <property type="nucleotide sequence ID" value="XM_022253910.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989494"/>
    <dbReference type="KEGG" id="aplc:110989494"/>
    <dbReference type="OMA" id="HYTKRAR"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06704">
        <property type="entry name" value="PDZ1_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06703">
        <property type="entry name" value="PDZ2_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06702">
        <property type="entry name" value="PDZ3_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06701">
        <property type="entry name" value="PDZ4_Scribble-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000779">
        <property type="entry name" value="Probable inactive serine/threonine-protein kinase DDB_G0278909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000064">
        <property type="entry name" value="protein lap4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000036">
        <property type="entry name" value="protein scribble homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000074">
        <property type="entry name" value="protein scribble homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF44">
        <property type="entry name" value="PROTEIN LAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="672"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="818"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="940"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="1036"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="440"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="767"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1456"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1509"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1554"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1613"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1252"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1325"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1480"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1622"/>
            <end position="1634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022109602.1"/>
        </source>
    </evidence>
    <sequence length="1658" mass="182968" checksum="E11FD3DCFA517898" modified="2022-01-19" version="1">MFRCIPLFRACNRHVDVVDRRHGNLSAVPDDVYRYSRTLEELLLDANQIRDLPKQFFRLQNLRKLGLSDNELERLPAEIGNFMNLTELDISRNDIIEIPDNIKYCKALTVIDFSGNPLSRLPSGFTELHHLAHLTLNDVTLENLPTDIGKLSYLLTLELRENLLKTLPESLSFLVRLELLDLGSNELEELPETLGALPNLMELWLDCNALSSLPPEIGNLTRLTVLDISENSLESLPDEISGLQSLTDLTLSQNCLEKLPDGIGKLKMLSILKLDQNRIMSLPSSIGGCESMTELILTENIIQELPPTVGNLSKLNNLNVDRNRLLHLIPEIGKCSRLGVISLRDNRLTRLPPEIGMLKELHVLDVSGNRLDWLPIQLANCNLKALWLSENQSQPLLNFQTDEVGPQQLKVLTCFLLPQRGPSESMENLLAGSIATNEEDNRVSWTEKPEKDKAIKFHDDKVDFEEHERPSNFVRHDTPHPRELKARHPKFAHQGHHKGKHNRSTDEDESQVGTDDEAEKRLSGSFKSPTETDPLLAGASGTVIVPTLMSTQLASPSPVANVEDDNMDDPLLKAVSVAPVQAEVPSSIDRRSGEISENDSEKHVGFSSDIEDQLEKTDLKLHRRDTPHYLKNKRVNLNEEPDEKTTALLNQVLARTAAEQAQREQPKYDRLEISFSREGGGLGISIAGGRGSTPYKGNDQGIFISKVVEGGMAFKQGLLVGDKVVSVNGVNLVDADHLEAVEALRNSTDHIDIVILRETEVKPDVTATANQENEESTAEVNLPPATVPDDSEPIKVQERPGVKFAPEPKVRLVQEKISVRLCKDSNGLGFSIAGGKGSTPFKGSDNSIFISRITEGGAADRIGVLQVGDKVLEINGVDMEYARHDQAVALLTSTKIISMLVFRESMEVEHHEPIVKHEPPEYYDQRADGYTNHVEPVKEDIRLVRTGGPLGLSIVGGIDHSSHPFGGNQPGVYISKIVPNGSAARTNLCVGDRIIRVNGVEMKHATHQEAVTALLSNPHEILLRVSHDPPPQGLKEIMIIKAPGEKLGISIRGGNKGHPGNPLDKNDEGIFISKVNEIGAASRDGRLCVGMRILEVNGQSMLGARHGDAVRALRSAGERIQLFVCDGYDQNEVAFWQARPGVVGNPLQHYDSNKRTSQESISSIDREMTTEELNRLNEESQYQQEADQWEKEELAKLDLTLKEAMRLQREEDTKLLMSDDNITNDNPMQKVTMRTLEDIEPPPPVAVEEPVQQNPTPVTESLPSPPVIANSYSSPEAEEDLPPPPPLTSPPPFSPPPAEEKPKKMGPPVAPRPAKDPAGRSKLVSTSSTATSRSSSTSSPPTSPQPVKKVAPPVAPKPPKWDDRDPSPPPTCPPTEEEREEMEKLKLAKQARKEALRVARLSCGSVGSRSSGTGSPILSPEIISPVLSPLISTQPMMKASGPEGLAFKDKWKRFEQQVDEQAHSTPKSTGKKVTLVSDQDLQKIKEDEDRRMHSMSEDDRMNYSRSITIETTPSKQATSDDIFNITGSSISPITGLPTEIRTAKAERRYYEKLKAEGHVSPDVNQEDGLEKGLSPAEIRAKEAEKRAAWRAARMKSLDDDALRAQMVLTQHKDAEDGLRFNALSNGNNKPSENGENPPVKVSPLEAELQFIDDENGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXF5</accession>
    <name>A0A8B7ZXF5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110988741</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108231.1">
        <property type="nucleotide sequence ID" value="XM_022252539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXF5"/>
    <dbReference type="GeneID" id="110988741"/>
    <dbReference type="KEGG" id="aplc:110988741"/>
    <dbReference type="CTD" id="3419"/>
    <dbReference type="OMA" id="VRPCRYY"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="36"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022108231.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="39408" checksum="6E226D2955BBB970" modified="2022-01-19" version="1">MALRTLSASYGPIWRCAAPSIRRLVGRRHFSQEPTTVTLIPGDGIGPEISASVQQIFAAAQVPVVWESVDVTPVRGPDGKTRIPPEAIDSMGRTKLGLKGPLATPVGKGHMSLNLALRKEFSLYANVRPCKSIEGYKTPYDNVDLVTIRENTEGEYSGIEHMIVDGVVQSIKLITEPASRRVAEFAFEFAKSNNRQTVTAVHKANIMRMSDGLFLQCCREEAEKHREVKFREMYLDTVCLNMVQDPTQFDVLVMPNLYGDILSDLCAGLVGGLGVTPSGNIGAGGVAIFESVHGTAPDIAGLDKANPTALLLSAVMMLRHMSLTEQADQIESAALAVIKGGKVLTGDLGGKASCSEFTRAICDHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXS2</accession>
    <name>A0A8B7ZXS2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Receptor-binding cancer antigen expressed on SiSo cells-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110989464</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109549.1">
        <property type="nucleotide sequence ID" value="XM_022253857.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109550.1">
        <property type="nucleotide sequence ID" value="XM_022253858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXS2"/>
    <dbReference type="GeneID" id="110989464"/>
    <dbReference type="KEGG" id="aplc:110989464"/>
    <dbReference type="OMA" id="DMVPQIR"/>
    <dbReference type="OrthoDB" id="10017216at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017025">
        <property type="entry name" value="Cancer-assoc_antigen_RCAS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208:SF2">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15208">
        <property type="entry name" value="RECEPTOR-BINDING CANCER ANTIGEN EXPRESSED ON SISO CELLS CANCER ASSOCIATED SURFACE ANTIGEN RCAS1 ESTROGEN RECEPTOR-BINDING FRAGMENT- ASSOCIATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034247">
        <property type="entry name" value="RCAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109550.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25721" checksum="570297D31CACC4B1" modified="2022-01-19" version="1">MATFRCNKWFICSFIAAVLGFLKRILFGRFHRRNRSDTNLPTLASNISTPAAADNSLSERNEDIADWDDWDYAGAPTDIIIEPNNPSIGPTAAEGGALAPVGGGVSPHDDDIPEMDYFSDMAPTLKKTVLIRKKDRSRAGLPNSGVSNRLSMNVDITPVASSELSAWDDEMDGTWEDEASALDLSRDADRVIKEKKQAERDRRAAEQHRKKMEREAQRAFKKDGGKLAVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY10</accession>
    <name>A0A8B7ZY10_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110989509 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110989509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109640.1">
        <property type="nucleotide sequence ID" value="XM_022253948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY10"/>
    <dbReference type="GeneID" id="110989509"/>
    <dbReference type="KEGG" id="aplc:110989509"/>
    <dbReference type="OMA" id="HESTIVP"/>
    <dbReference type="OrthoDB" id="8961218at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042509">
        <property type="entry name" value="ZCCHC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639">
        <property type="entry name" value="GAG-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22639:SF3">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109640.1"/>
        </source>
    </evidence>
    <sequence length="564" mass="61553" checksum="1CE5CEC699A4AEB8" modified="2022-01-19" version="1">MVTRFNDIVIITIHYISMCIHDSIVRSILSEFGEVIAGRFTTYGDNPTVFNGTRQYKMKLTKPIPTVLRIGDRNAWVSYPGQIRTCARCGEQGHYARDCTNTKCFKCLQIGHVAGDCPNQVICTICRMEGHSFRYCPKSFAKAVQPDRAWSSVSSNPSTSSGDQVAIAPDASSKEKGLKELPAGKCLKCKQSAGPFHPSICCFSCKLPLSFSKPFSILECAACKGVNGQPSLVCHRDSCKSVQAPESNDGFRVVRRRKRAAKRSSSPPVQPSTKKATPMPSSTGGGGETAPTAADIFGSDLDSVSSMDSCPARDPVRTHSSSSTSASDLSSSENSGDESTFDRDSTSDDEAAGIDSRVQKKVRQHLMALDLPGFSEPTDSQGRIVCCSLDGPGWCAKLIGVYAPNNPLHRRNFFLNLSNFLTGNGPFILAGDFNCVLNSSLDRIGTSTLSCDIGSQELQHLCDDMSLIDPWRVSHPNLHEYTWRNASNSFCSRFDRLYISNCLSCSSAVHLPVFFSDHDGAVLNLRPASVPERGKGFWKCNTSTLSDPIFQSDFKSAYVGWRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY45</accession>
    <name>A0A8B7ZY45_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Uncharacterized protein LOC110989933</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110989933</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110338.1">
        <property type="nucleotide sequence ID" value="XM_022254646.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110339.1">
        <property type="nucleotide sequence ID" value="XM_022254647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY45"/>
    <dbReference type="GeneID" id="110989933"/>
    <dbReference type="KEGG" id="aplc:110989933"/>
    <dbReference type="OMA" id="CELHCNG"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF40">
        <property type="entry name" value="AGAP006757-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022110338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022110339.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="57673" checksum="DB8C6494A9DB97B9" modified="2022-01-19" version="1">MSSRDGTAAPALQTLFKRVPSIRDRTRRASLGQISGTLAIHNAVAKGKIHLAKFILDAVEGQPLVDARDAHGKTPLIRAMRVSDAETRNKVVDLLISYKASVNLVDHVGRSALSYACELHCNGVIRKLVRNNVDPNSEDHNGNTPLMYCALANNAEAIEIISRSFRRLGLEVDKVNADGMTPLMEAAKNGYIDCARLLALEAKASVVIRDEVRNMNAAEWAREAGCSTSEVEVLLPKQPYTEKMTEKGLLSHCQTKTIATKNGALASQRDVHITSVVEDLLSHGLTPLSLCTTSDSSLTLETGNGAVSRQHFTYMDELVCRSKELLLENRSHDLPATGFSFPDVHGVGKQHPAGHEHHQFPLFDKDVQDNSPTLSKGISPSSTSRGGLFTRRPQPPAAPMRPCSAAAQKPHRRVRGHAGQTSSSMEDLLLMADPTEPIIRSSSQSPLKSSSMSRLTYQRGDASELGSPRFDKRSIESDTHIDLTILPSTLSGRLRTSSQPLPNTDPYIISDNSASVSCTHLPPISPKFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZB2</accession>
    <name>A0A8B7ZZB2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110989761</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022110065.1">
        <property type="nucleotide sequence ID" value="XM_022254373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZB2"/>
    <dbReference type="GeneID" id="110989761"/>
    <dbReference type="KEGG" id="aplc:110989761"/>
    <dbReference type="CTD" id="285203"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="11">
        <location>
            <begin position="311"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022110065.1"/>
        </source>
    </evidence>
    <sequence length="580" mass="68167" checksum="44D3E0EAB7108E98" modified="2022-01-19" version="1">MRGHAYMRKDPNMNLPCFRCMLSTMCAFLLFVLYNIPHSHCSSKLETADLNVNHIPLDSKMTPTVQQKSTRQERTNTVDGKVCFQDPNLHPEHYRYYFNRHPDEAEACRLDPTCPYKEYLDTSACWGYEEGCTRESMPGYPKVHKFHKSWFPSKEAQIKQFWDDNDFGYIKKIVDDGWYPLCTPKTQNGSLLSCVDNTRSCYAKNLFLRVPDFEDHSKLRGRFDTEHFGSPGQIGGHCNLDKELLKKHSNHFSELQSWYGELREFTALKADPFVTSSCDVVIEGRAYLMKMDAGINMFHHFCDFVNLYITQHLINDFSSNITIVMWDMSNMRYVDFFEDTWAAFSDRPLARLNHWSRKKVCFREVVFTLPPRMIRGFFYNMPVIPDTHGSRLMRSFSQHILHRLGIKQKGPLKTGKVRVTILDRKSVHRNIVNQEELVEALREDPSYEVQLVVYNHTLTFVQQLEITHNSDIFIGMHGAGLTHLLFLPDWATIFEVCNCEDKHCYEDLANLRGVHYVTWVNYSRLKKHNEVLHPSLKTYHPKFCDYSFEKAEFVRLVKKAHLYVRNHEKFKFEEALHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZM8</accession>
    <name>A0A8B7ZZM8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Caldesmon-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110989173</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109035.1">
        <property type="nucleotide sequence ID" value="XM_022253343.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109036.1">
        <property type="nucleotide sequence ID" value="XM_022253344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZM8"/>
    <dbReference type="GeneID" id="110989173"/>
    <dbReference type="KEGG" id="aplc:110989173"/>
    <dbReference type="OMA" id="RVAEDWD"/>
    <dbReference type="OrthoDB" id="10243838at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665775" evidence="2">
        <location>
            <begin position="17"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109036.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44732" checksum="BE62C611661316C0" modified="2022-01-19" version="1">MKVLLLVAMCVGLVCSASLFAEERSLDDLKAQLVRELKDRLAQAEQEEEREAVGETEAAEQPAEEQRNDFADAFQETDQEKTDERSLDELKAELIRALQDRLDQAEEEEEREAVGETEAAEQPAEEQRNDFADAFQETDQEKTDERSLDELKAELIRALQDRLNQADKEEEREAMDETETAQEPAEEQRNGFADAFRENDQAEEADERSLDDLKAELIRALQERLNEGEKEDEERRALLQKEAAEKRAQAVEAEEKERTALLDKEAEEKRAQAEEADERSLDDLKAELIRALQERLNEDEMEDEERRALLEKEAAEKRAQAEEADKRNLDDLKAELLRALEARLNEGEEEELERAAFLDNETEEKRENEDNVERELFDELDDLEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZU6</accession>
    <name>A0A8B7ZZU6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein LOC110990104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110990104</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110632.1">
        <property type="nucleotide sequence ID" value="XM_022254940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZU6"/>
    <dbReference type="GeneID" id="110990104"/>
    <dbReference type="KEGG" id="aplc:110990104"/>
    <dbReference type="OMA" id="WHENTIH"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00201">
        <property type="entry name" value="SO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033988646" evidence="13">
        <location>
            <begin position="19"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="910"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="939"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1014"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1058"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1111"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1138"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="142"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="15">
        <location>
            <begin position="266"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="16">
        <location>
            <begin position="396"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="14">
        <location>
            <begin position="904"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1173"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1182"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022110632.1"/>
        </source>
    </evidence>
    <sequence length="1203" mass="134187" checksum="5B1E59E4BF1AF886" modified="2022-01-19" version="1">MDVILPCLLGLTVVLRHGEVVAGTRANLTGLRVVEGRYRSEGRVEVRLNGQKWWGSYCTIDDRDLLHGAGRALCRQLGYPALLEASNTAQFGQATGPIWLQEVNCGYTLHPLQECYLHRWMPSWGGCDHMDDVGIRCFTGKVRLVGGKQENAGKVELQIGDDEWVSVAHGKVQGRELASDLVCRYLGYPFAIGATPEKADNDTGRFIHALQACDWETLDNRRALFDCIDEYLLTLYQNQGRQSTALLGVVCATENEILPNTSTPEFRLNPLGTGLNESRHLGFLEGRYNGSEWRTICVHKLDMCPGVIFRGLANLACRDIGYPRAENRRDIRYSQASYKGTGNDLVLRYTYLRETHTNGKRWLFGQNSCQDHDYNLILVECDTGVTMYGLTVYPCPSESCQGRCGSLASERQCGCDALCMLCNDCCYDYYKWCPSNLSNVSKELWLAASSHELLSCVVVGDKRAVIIRGCPREWQDKEETPPCVNDSRLVQVAYRDTTFVRMYCALCLYKNTVIINTVLAEHQSSADILNSDSSDEDYNFNSSDTTHATQDERLNFTYTSYDVGIDNCSAPDIRVEIQTGCRAYSAPIVAPDGLVYKNPHCAHCNGMHLFALDYSPCRDSLVCSGVKSTRLFTRTVHIYTPETSNDFSLLREAYCFDKQYALLVQSPILNPPEKEQNTSSLPQPSGVMMCYLFLLSQQNVQLTWPFYLAAIKGREVSGFEKGASGVSTSYLGNVTDFEALLDESALDQINGTRKWVVRCGITRVDFVETCGLIVGSIEPCEDSLYTTKAEILTTFNFSGIQVVYVGGGLLVESKWVSFNRSYRYQPKLSKTSAKDTGRPIEVCGEPYVNEECQIPLTQSTRLLTMGGAPAVEYKRKVFFKDHVVYLPDDRILICDIVFAKRDPLQTFNCVAFSVSATTIFATFITYCAFPVLRNVPGRAIMSLSAAMTAAQLLTIITFGKTEPEAFCLTVAPVMHLLWLSTFTWTNVLAFDLARTFSSKQARRPGRYVFSVYSLYGWGVPLLIVATCLAVHFADSGGIDFRYGMGPGEDSCWLSGKHAVVIAFVAPIACCLVANIIMFAWTVRSVHASLVAAALVHTRQSKAKEKIREFGIYLKISGVMGFTWIFGCLANRINHEVLWYLFVVLNSLQGVFIFLSFGCNRRIRDLWREKLGLKPQSGTSSDAKTKKSSENVRVKSSDQSASNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0W8</accession>
    <name>A0A8B8A0W8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cholecystokinin receptor type A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110990348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022110997.1">
        <property type="nucleotide sequence ID" value="XM_022255305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0W8"/>
    <dbReference type="GeneID" id="110990348"/>
    <dbReference type="KEGG" id="aplc:110990348"/>
    <dbReference type="OMA" id="CKLMHFI"/>
    <dbReference type="OrthoDB" id="10053542at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022110997.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43608" checksum="493254E8A5AD99D7" modified="2022-01-19" version="1">MESFLWPLLIFHAIVGIVGLPGNALIILVYGKKRQLMSPHVFILALAVADLIICLFTPITIYHWYIKLNYTSDFLCRLVVSVTFITVYNSCFLTSAIAVDRYQAICRPHRRWMTVQRAKYAALLCLVLAMFCAVPVFASYHVQREGESQTGICTISTKVPSWVKYLKFSVTYVAPVSSIVTNTILYAKIYFAIRKQAAVRPGAVPSNKVVTETTPPQPNQELQGTVSYIGIQSERYIDGPCTTKHSNVIPNFKGALTHQHQNNQTDGPPPKTNRHTNDVTEVALNDPNKNHQYASAKFNGKTTKMLVITTVVYFSTWLLGISLMSIPRHTQNYILEHDEVGAAFFHTFSFVFYVNNAVNPFIYGFVNSRFRQECKETMKTVRCHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A156</accession>
    <name>A0A8B8A156_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110989482 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109576.1">
        <property type="nucleotide sequence ID" value="XM_022253884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A156"/>
    <dbReference type="GeneID" id="110989482"/>
    <dbReference type="KEGG" id="aplc:110989482"/>
    <dbReference type="OMA" id="ICIRRGD"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022109576.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="20942" checksum="E1529DE1029575D8" modified="2022-01-19" version="1">MTASPEQLRDISVESARPSRLEETPAALTFSDVSRLSESRDSTQPSSLQMEQSTLRHKRRLTEKSIEEEVTIPGDQMLIMDLPDEILPEHQIETLQDIPEVHKSPDIGASEEDQVISVPHPNVIREIAHLTAADETITFKDLVPVTTTCTDASKVFSVCLDYAALKLIKLWQTLAYGDICIRRGDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A353</accession>
    <name>A0A8B8A353_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ras-related protein Rab-21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110991186</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112114.1">
        <property type="nucleotide sequence ID" value="XM_022256422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A353"/>
    <dbReference type="GeneID" id="110991186"/>
    <dbReference type="KEGG" id="aplc:110991186"/>
    <dbReference type="OMA" id="NDEQHRN"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04123">
        <property type="entry name" value="Rab21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000550">
        <property type="entry name" value="ras-related protein Rab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041833">
        <property type="entry name" value="Rab21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022112114.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23115" checksum="DCD9B449A3DFB629" modified="2022-01-19" version="1">MATGGGGGKNFKVVLLGEGCVGKTSLVLRYVENKFNDKHLSTLQASFLNKRLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDITDEDSFSKVKNWVKELKKMLGNEICLCIAGNKIDLEKQRNVSIGEAEAYAAQVGAKHYLTSAKLNKGIEEMFLDLSKRMLESTPSDDLGRGTSSSRSSRKTVTIVDDEEAPKQGGGSCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3F1</accession>
    <name>A0A8B8A3F1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110991075</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110991075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111902.1">
        <property type="nucleotide sequence ID" value="XM_022256210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3F1"/>
    <dbReference type="GeneID" id="110991075"/>
    <dbReference type="KEGG" id="aplc:110991075"/>
    <dbReference type="OMA" id="WVGKGKP"/>
    <dbReference type="OrthoDB" id="10040891at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002072">
        <property type="entry name" value="Nerve_growth_factor-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00243">
        <property type="entry name" value="NGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50270">
        <property type="entry name" value="NGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034714496" evidence="1">
        <location>
            <begin position="38"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Nerve growth factor-related" evidence="2">
        <location>
            <begin position="187"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111902.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="29022" checksum="AF65E1DB2D162FB4" modified="2022-01-19" version="1">MPSDKTMPFCTEGTLMRLNVCTALFFLLLCVCHTGVAEFADQPSDVFKGYDFGVDFQDSSSPLPQAIQDNGMLHLVLHYLSLKLIREMGAEEETRLTKRQSKMVHDKVTAFYDEILKHPALNSNRIAFSQKKPDFATFRPDHPEGTSLPHRRGKRAAGILTEICTSVRGWEQENRGVTRNHDVVNLYPDQHFYTTRCLSNGQSCNYINDWRVTSECTTRSSWTIAYVEVNDGETVRYDWEWIAIDTCCSCAASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A5A2</accession>
    <name>A0A8B8A5A2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990428</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111121.1">
        <property type="nucleotide sequence ID" value="XM_022255429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A5A2"/>
    <dbReference type="GeneID" id="110990428"/>
    <dbReference type="KEGG" id="aplc:110990428"/>
    <dbReference type="OMA" id="VPMRYSF"/>
    <dbReference type="OrthoDB" id="10055960at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111121.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="47351" checksum="762E07DC7A49F987" modified="2022-01-19" version="1">MWEVMDFSRTDREGASFNPLPQKVPMRYSFSIEQKRILMKHYEKGMHGQSLAYQDKIVACAQEAGVDFDIVRNWIGNMRRKRRMESAQRNPMPGIVLQHDQSVENKRRYLSTTSAFGGPQNLICHPPDGGQQPNQMGAAPRVIGPGLHNALPPGTVRNAPLAPRDPNVNQPSLGPVGIGQPGTSTAQAMFLTTPAKQELDADKSSCLVASTALQSTSHPQQLHVAGLNTTGVDRFPDETIPLVINQGSTVNQEVEEGEWRQQQIQKIMQQIQQSVHQLESLGCECVVASVIPSDGGTYITGTPVAVQYFSEIQKIQAMADYVNPTTPTSVTSDNVPNDAAEEVNDASNGQRKQPGQATNTKEEAGDRECLEARGGDHTEEEKAGKVDLDRRDGEIIHAGEEVYIVNKEHYIIGTGTLLPAPHKRIELKNTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A7S7</accession>
    <name>A0A8B8A7S7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Early endosome antigen 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110991176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022112101.1">
        <property type="nucleotide sequence ID" value="XM_022256409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A7S7"/>
    <dbReference type="GeneID" id="110991176"/>
    <dbReference type="KEGG" id="aplc:110991176"/>
    <dbReference type="OMA" id="FFARMET"/>
    <dbReference type="OrthoDB" id="10056516at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049146">
        <property type="entry name" value="FAM186A_B_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20865">
        <property type="entry name" value="FAM186A-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM186A/B C-terminal" evidence="3">
        <location>
            <begin position="534"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="33"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022112101.1"/>
        </source>
    </evidence>
    <sequence length="790" mass="90778" checksum="DE8B7B34D0115DC5" modified="2022-01-19" version="1">MSVAVERRNEENMQLCEQILEFGVSVNHLTKGNEKLERDLSKKTTRLEALENFTEKQNQKIKELQNQLKDMKHSVDQAKAVKKLNPKEEAQREAALKAAQKETARLQEEIKTLQAQATAREDELVREVEHTLAKLYDAEDTIDKLKQVVENLEGQLADIQEQAEEYAHQLDITHFQSEAKQSQQSSMREQYQQRIKEYKQEVDDMDREITHLKDVIKLKEEAILLQEKKIAELAAQMKHHAAAAATPPPAKDVTPPPGASPEVRNMLARMKGEHEMELHTLKDYAAKEKLRCDATLRKQENEMKLQLANILKESNRLLRAVNRFKDGLAAILEKEGLLDTAHDVRQLSNLPVEDKPSDVKIILGQMAGNAVELLVSLELKIAQALMNKRLELKEALMPKQRTLTPLVEVDPEIEKLTKENGYLSEKLEKAQELLHATEVMLSETKRINDEKYKALLDRHKALILHSSSLQREMKSLEQAFREETKKRDMKLRSMKGSMAEQARQQQTLVTQLKMDIESSKRVEKPPPDIGQLRLRVSDQLRNLEMLESALKEDKISLELHTITCDIIKQTIEVPEMRLRHMFERYIIFRRMQEQKAELISKLEGPVTREQDKKLQGFFARMETRMSENINTWREKREAIKQERNNLYEQMLAIFDVVGQETGLSLARPAEKVAIFRRAKRSRAHLILGPRGVRMKVPMEFKTNKLIGTSVTLIGDHGPFWKMPSNLHGGTDLVTVPKILEMDIDARRKTAKEVLQRLGIGDTSKKEQPPSRQSQEPSVPPLATLFPPISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIH9</accession>
    <name>A0A8B7XIH9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Steroid 21-hydroxylase</fullName>
            <ecNumber evidence="14">1.14.14.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">21-OHase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome P-450c21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytochrome P450 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cytochrome P450 XXI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytochrome P450-C21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110973334</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.16" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022079740.1">
        <property type="nucleotide sequence ID" value="XM_022224048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIH9"/>
    <dbReference type="GeneID" id="110973334"/>
    <dbReference type="KEGG" id="aplc:110973334"/>
    <dbReference type="OMA" id="WHKPYEF"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004509">
        <property type="term" value="F:steroid 21-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000049">
        <property type="entry name" value="steroid 21-hydroxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 21 22" id="KW-0349">Heme</keyword>
    <keyword evidence="10 21 22" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 22" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022079740.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57058" checksum="B12581F4B9D8DF35" modified="2022-01-19" version="1">MILLVLLYTALAVLICLLLHFLYEEHIFKVLHLPPGPRSLPLLGNIFQINPKQLHLSLSDLARKYGATFSIKFGRERVVILNVAETVKLAYSGEAITSRPKIFSIDFFISKGFMACTDRQHFKIHTKVMKHAFRVISNTSLGTKLADEADSLIKTFEGYDGQPFDPRDDTNLASLNVLYNIAFGKRYQKGDAELQEIFDYSHDIMKGVSPVHPINLIPWLQNIPNPWMDSLQRAKDKRDHHLLTLYQQHMDTYEEGTIRDMVDALIRVARKAEKEDDCQTLELLSPEHITTNIWTIFFAGTDTVLNALLWVFLYMAAFPKVQQRIQSQIDEAIGRGRLPSLEDELTLPLLSATIYETLRYSSLSLLGVPHAAVMDTEVDGFYIPKGTQVMANFWAINHDQQVWHKPYEFDPDRFLDPEGRLRSLKEFPYFMPFSTGQRACLGKNIGKSEVFVLSACLLQRFTLEMPPETPQDLQPNIHFDLVPKPYKIIAKRRNLPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XK90</accession>
    <name>A0A8B7XK90_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110973680</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080370.1">
        <property type="nucleotide sequence ID" value="XM_022224678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XK90"/>
    <dbReference type="GeneID" id="110973680"/>
    <dbReference type="KEGG" id="aplc:110973680"/>
    <dbReference type="OMA" id="VILYSAC"/>
    <dbReference type="OrthoDB" id="6275059at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01099">
        <property type="entry name" value="PAN_AP_HGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="114"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080370.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26325" checksum="2225C7A3D9BB4055" modified="2022-01-19" version="1">MAKVNAGLQVMIILGAVIFVGGHQCNQRQQIMHAAENHALRGFAYWQNTVRSRVVCRRECSMNARCKSFNFNDCNKLCELNLATRREQPGDFIATHRSVYFDADEDSPLFSFTNNSLKYSESCKMLLDAGHRSSGVYTIYPGGYYADCLLVYCDMDTDGGGWIVFQRRQDGSVDFYRIWTEYQSGFGDLSEPVIHIHCGREVVCCGPGGKLPPKRIGVTGLLKLDRLPTWAGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQE4</accession>
    <name>A0A8B7XQE4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110974737</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022082251.1">
        <property type="nucleotide sequence ID" value="XM_022226559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQE4"/>
    <dbReference type="GeneID" id="110974737"/>
    <dbReference type="KEGG" id="aplc:110974737"/>
    <dbReference type="CTD" id="55661"/>
    <dbReference type="OMA" id="MIDPPKQ"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000842">
        <property type="entry name" value="ATP-dependent RNA helicase DRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="234"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="420"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="94"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="652"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="582"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="678"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="776"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022082251.1"/>
        </source>
    </evidence>
    <sequence length="792" mass="90660" checksum="6197C62EDD52DF22" modified="2022-01-19" version="1">MALPGDFIGTIQEDEEIPVASEDTSSDEEALRPKKLSKLKRQKKGQEDFSQDFVFSERAFDENSAWTSNLIKTLKPRGHTLIQTNTSLEQKIAKIRSEKRKKKESEELDKAKAKELDVTKGDHAFQSGAKEDSNHDNSADDEEEEIEDEDMGVEDMTWDQIKVKSTSEKRIKRKHKKDDSDSDDEETKKAKFFDEAPELAGYSSFQEMNLSRPLLKAITAINFVRPTPIQAQTIPVALLGKDICACSATGTGKTAAFMLPVLERLLYKPKQALTITRVLVLVPTRELGVQVHTVTRELAQFSSIECCLAVGGLDVKLQEAALRKGPDIVIATPGRLIDHLHNAPSFDLKDVEILILDEADRMLDEYFAEQMKEIIRLCSHSRQTMLFSATMTDEVKDLVAVSLKNPVKLFINENTDVAYNLRQEFIRIRPNREGDREAVVAALCSRTFHDHCIMFVQTKVQAHRLHIILGLFGLNVGELHGNLSQAQRLETLRRFKEESIDVLVATDLAARGLDIEGVKTIINFTLPSTLKHYVHRVGRTARAGKSGRAVSLVGERERKLLKDIVKKANNPVKSRIVPQDVVQKYRDKIASLEEDIGEVMRLEEEEKEMRITELQMHKANAMLEHQKEIFSRPKRTWFQTHKERVQEIDKLKLNPEKMDKKSKKKAKKEQAEQVASDQNERRIQRELEKAQLFSKREAKRSHKGHVIRGLRNQEQPSENKKPFVRKKKTNGGQFKSSFEKELTQTGKRSVKQFRNKTHEARKEQKRTEKASFKSSKQNKSKFKPSKFNKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQH1</accession>
    <name>A0A8B7XQH1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110975170 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110975170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083073.1">
        <property type="nucleotide sequence ID" value="XM_022227381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQH1"/>
    <dbReference type="GeneID" id="110975170"/>
    <dbReference type="KEGG" id="aplc:110975170"/>
    <dbReference type="OrthoDB" id="10011873at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022083073.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20378" checksum="FFDD1BE9019AA334" modified="2022-01-19" version="1">MALCSSRRFTMDLSVLGVLWATDTKITVRAGDSEPVTVLNSPSRLLALGKPDKHGGLNPVDSVVLTADRGYLLWINPRGSIEVKFRYGRSGENFNCFIDPQHQGVTIYELCGTYRKEMVVDGRQPLSKNTNPHHVKPTGVRRRENNFEFRSRNSEVRLVLETVRDSPPQQAFKFNYVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRB0</accession>
    <name>A0A8B7XRB0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prostaglandin reductase 1</fullName>
            <ecNumber evidence="4">1.3.1.48</ecNumber>
            <ecNumber evidence="5">1.3.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dithiolethione-inducible gene 1 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leukotriene B4 12-hydroxydehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NAD(P)H-dependent alkenal/one oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37 38 39 40" type="primary">LOC110974899</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="37 38 39" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
            <dbReference type="ChEBI" id="CHEBI:133975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:51213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57460"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133346"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:51209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58968"/>
            <dbReference type="ChEBI" id="CHEBI:156112"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:64738"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:90723"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:51205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13737"/>
            <dbReference type="ChEBI" id="CHEBI:12834"/>
            <dbReference type="ChEBI" id="CHEBI:13757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.74"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:13739"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>decanal + NADP(+) = (2E)-decenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31457"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133455"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:50614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanal + NADP(+) = (2E)-dodecenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27836"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133741"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:50786"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>hexanal + NADP(+) = (E)-hex-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28913"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88528"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:50778"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:50609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77927"/>
            <dbReference type="ChEBI" id="CHEBI:133457"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:50618"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>octanal + NADP(+) = (2E)-octenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61748"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:50782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>pentan-2-one + NADP(+) = (E)-pent-3-en-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16472"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145276"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:50790"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer or homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="4"/>
    <dbReference type="EC" id="1.3.1.74" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022082526.1">
        <property type="nucleotide sequence ID" value="XM_022226834.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082527.1">
        <property type="nucleotide sequence ID" value="XM_022226835.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082528.1">
        <property type="nucleotide sequence ID" value="XM_022226836.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082529.1">
        <property type="nucleotide sequence ID" value="XM_022226837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRB0"/>
    <dbReference type="GeneID" id="110974899"/>
    <dbReference type="KEGG" id="aplc:110974899"/>
    <dbReference type="OMA" id="YPIKNIH"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08294">
        <property type="entry name" value="leukotriene_B4_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014190">
        <property type="entry name" value="PTGR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="35">
        <location>
            <begin position="18"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="RefSeq" id="XP_022082526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="RefSeq" id="XP_022082527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="RefSeq" id="XP_022082528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="RefSeq" id="XP_022082529.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35486" checksum="54A3AFA2D20E9109" modified="2022-01-19" version="1">MGKGKKWILEKHFQGMPKRSDMKIVEFDLPTVPDGSFLVEAICLSVDPYMRPYSARLPEGITMIGTQVAKVIETKNADFPVGTLVVCPGGWTTHSLCKGENESKLPPYPEGVPLSLALGTLGMPGMTAHYGLLEICAPKPGEVVVVSGAAGAVGSVVGQIAKIKGCKVIGFAGSDEKVAWLKELGFDEAFNYKTIKNLDATLKSVAPDGINCYFDNVGGEFASTVVTNMAKYGRISCCGAISQYNDTAPQKLPPVFGTLVFMEIKMEGFIITTHIKHWPEWTKQHIQWIKEGKLKYKEHVTQGFDNMFDAFLGLFSGANTGKAIVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRH6</accession>
    <name>A0A8B7XRH6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Kelch domain-containing protein 8A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC110974932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082600.1">
        <property type="nucleotide sequence ID" value="XM_022226908.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082601.1">
        <property type="nucleotide sequence ID" value="XM_022226909.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082602.1">
        <property type="nucleotide sequence ID" value="XM_022226910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRH6"/>
    <dbReference type="GeneID" id="110974932"/>
    <dbReference type="KEGG" id="aplc:110974932"/>
    <dbReference type="OMA" id="FPYPVHH"/>
    <dbReference type="OrthoDB" id="8185403at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051746">
        <property type="entry name" value="Kelch_domain_containing_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46260">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46260:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022082600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022082601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022082602.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="39877" checksum="58FCA72CBFB608C1" modified="2022-01-19" version="1">MATAQPGADSGYRWETITNALIKRVFSSVIAVSGQLFLIGGSDAQGKGTDDFHCYNPKNKKWTRLCNIPTARAGTAVVAVGTTIFVLGGVGVDAIPVDVVESFDVSNKKGQWNKDIKPLADRIQGLSAVAYNGKVLVVGGMKPDTTPCEKCNVLDPEKKLWLSLPDLPTPRYAMGTFLKGDKLYLVGGRIAKNICPAVEVLDIVERQWTSLQPVPTKRAFPCNVSIGRYIYCIGGLKENPKDGFYKVVEEYDIEKDEWKEMEPMQYERGDFTAEVVGDKVIVVGGMGHSKEPHRNGEVLDPETKTWSALPPCPTSRSSSTSTMMDGKLYILGGMTPNGLTLAVDVLSIKEQSTGSQSATRHTGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRW6</accession>
    <name>A0A8B7XRW6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110974996</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110974996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082711.1">
        <property type="nucleotide sequence ID" value="XM_022227019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRW6"/>
    <dbReference type="GeneID" id="110974996"/>
    <dbReference type="KEGG" id="aplc:110974996"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022082711.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26068" checksum="F2B055A437B5CECD" modified="2022-01-19" version="1">MKWLVVFPLVSSLLAIAAIAVGICVSSGALFIQPRALSGIVYVSIALVLVSKVLHENMLRLFALTRSNSKTRSKIHCLNMFSALIGLVGLLSVTVAYATPNPVFGMTKSSLQTAMEILGCVSAALYCAVQAHLSKVVRPELCSRCVVNLRRTLTVFVTLQAVTVIVLGNILPLVLPVTLSNLHLLRLSRLSDGILKYVLVSVVCVYLLTFTHEFSKEPPNPNDRSSSKNAVEPEPMPNPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XS75</accession>
    <name>A0A8B7XS75_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lactadherin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083708.1">
        <property type="nucleotide sequence ID" value="XM_022228016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XS75"/>
    <dbReference type="GeneID" id="110975482"/>
    <dbReference type="KEGG" id="aplc:110975482"/>
    <dbReference type="OMA" id="QCICADA"/>
    <dbReference type="OrthoDB" id="10028859at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF325">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034494778" evidence="1">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="112"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083708.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29377" checksum="9D8410915953A6F2" modified="2022-01-19" version="1">MRLLCTVFFFGLLVMASEVLETCAILTGQVPQVLSYSLDKLGVSLQMHKVVASSVQTSKMRCAATCMATASCTHFCYEPTTKRCLLENADSDIVSKSLENTGICYQTCSVKCSTPRPLGMEDYTITNAQISASSNYYTGCCHAHYARLNRLIRWSPLSGDSYPWIEVDLMERTVVSGASTQGSPFDYWYVKKYKVAYQRQPSSERVYVTDGKGHVATFTGNTNRHAPVTNLFDESVVATSVRIEPTSWNGWIGLRFELLGCPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSD7</accession>
    <name>A0A8B7XSD7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytosolic non-specific dipeptidase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110975526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083773.1">
        <property type="nucleotide sequence ID" value="XM_022228081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSD7"/>
    <dbReference type="GeneID" id="110975526"/>
    <dbReference type="KEGG" id="aplc:110975526"/>
    <dbReference type="OMA" id="CYYFITI"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000014">
        <property type="entry name" value="Cytosolic non-specific dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="222"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="8">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022083773.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53809" checksum="C53DC8CB753D479C" modified="2022-01-19" version="1">MADDFLPQLFSFIDKHQDDYVRRLADAVAIQSVSAWPEKRSEIKRMMEVVAKDLRKPEVGATIELVDIGTQKLEDGRVIPLPPILLGHLGDDPKKKTVCIYGHLDVQPAKREDGWDTDPFVLTEKDGKMYGRGSTDDKGPVLAWLNVIEAYRALKQDIPINIKFCFEGMEESGSVGLERMIESRKETFFKGVDYLCISDNYWLGRNKPCITYGLRGFSYFFVEVECSRKDLHSGVYGGSVHEAMTDLVVLLNSLVDVKGHIKVPGVYDKVAELTEEESKLYAPIDFDMEDYREEIGTERLLHDTKEKVLQHRWRYPSLSIHGIQGAFEGAGSKTVIPRKVTGKFSIRLVPHQSPVEIEQLVIKYLTDIHKARGSPNKMSVSVSLSGVSWLSDFNHPHYLAGRRAIQRVFGVEPDMTRDGCTIPVILALQNATNKNVMLLPMGACDDGAHSQNEKMNLSNYINGIKLLGAYFEEVAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XT55</accession>
    <name>A0A8B7XT55_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nephrocystin-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110975187</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083111.1">
        <property type="nucleotide sequence ID" value="XM_022227419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XT55"/>
    <dbReference type="GeneID" id="110975187"/>
    <dbReference type="KEGG" id="aplc:110975187"/>
    <dbReference type="CTD" id="4867"/>
    <dbReference type="OMA" id="HESEWEN"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090251">
        <property type="term" value="P:protein localization involved in establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11770">
        <property type="entry name" value="SH3_Nephrocystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039687">
        <property type="entry name" value="NPHP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030642">
        <property type="entry name" value="NPHP1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15176">
        <property type="entry name" value="NEPHROCYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15176:SF1">
        <property type="entry name" value="NEPHROCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="558"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083111.1"/>
        </source>
    </evidence>
    <sequence length="1074" mass="122608" checksum="2EC7B8C85C0662CF" modified="2022-01-19" version="1">MATPKENMRTLIREGDALKKEVDAFAVECQGVIEDMGLSDRKQRMKKLLQRSKDLIKKTTKMEQRVSKHTKGKETTPISRFDDVKADELKRLRNLKNRLEKLKESLIPNETEEEYFRQMGDEAGATSTSKVISVGPGANSTLEDEEEEDEEEEDEEEEEEGEKDVEGDEEIEEERDEENQEEKSSPGKSGSKLRRMSLFRRSSKSSKDVAAKLKATEAGVPEETKKERKEREKRERLLEKEKQEQAKREKREQEKREKQEKERLEKERKEKEKEKKKGRADKKGVGKGKLGKSSGSQLDGISEQSEEDEEDEDIEEEEDHEENYENDGKDKVEDGEIDEVDEEDEGDDDGDEDDDKQQGEVNIVEAKSPRMASKRSLMKSPFGRRQKDGKKDGVPPEEPKPPKEKKGWKLFQRKTDRKMTASTSSDAKEEDATSKQATSKEDAAKNTGTSKANSLPEEVESEDNGEEEEDDEDEDEEEDDDDEYEDDEEVSAEDEEQGEEVSEEEDDEEEGEDDEDDEEEDEDEEQDDEEYEDDSQYLDELGGTGGSNASDIFSPPDEGMERYEAVCDFAPEQTEDLAFRRGDILTVINTRDDGWWMAEDEEGNRGLVPSTYLKLKKDYGDYRDVQSPEEEDQARAQGGRRKSGLELWKGLRKAMNETSVTDVLTAMGAIPSGFRPSTTARLLKEDQYMLSNVLKPRLSQSYLAFKDLYWNPKDNQIRARTVRVQKMVSLMMLKNMPQVGAGLEIKTRHIRLAVFDGDKVLSNIHTVQATFVESDPRTWKFSPKMTSMLPSTLDGDCFVRTNHTDQNIGILFEICISYLRTKTGEKGELSCGWVHLPLFDEATGGPAVNKVYEVPIKGGTPYEPDVDVDPSISRKASTSKFRSMMTASKNPRLVVKLSMPTKEQKADLDTLPDTVVSCSCYISSLSMYRRLLAEAALIDRIDLQNTDLIHSPVLSSFPEALQYPDIMDALRNCWAYKRRTMKKSDKRDLGQMKKFFVDACMESIYLLLQSATLPAYKFGDKENEQERWEEISDMMQKNRTRGVLDYLLKPGVMHAPFDIGEVTFNLLQVYHEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTG6</accession>
    <name>A0A8B7XTG6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110975727 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110975727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084144.1">
        <property type="nucleotide sequence ID" value="XM_022228452.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084147.1">
        <property type="nucleotide sequence ID" value="XM_022228455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTG6"/>
    <dbReference type="GeneID" id="110975727"/>
    <dbReference type="KEGG" id="aplc:110975727"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022084147.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="15161" checksum="B072DF62A9B5BB25" modified="2022-01-19" version="1">MSGQHQWRAQNLKAGSRETQVPVRTQVTATDSDEEQEQWMEKTAGVKGDSSVVGPLPVGSSSITGLIELGDSSVVGPLPVGSSSITGLIELGDSSLVGPLPVGSSSGITALIEFGKASLPGECTAMAAYVNIEAAWLASWCEWTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUN7</accession>
    <name>A0A8B7XUN7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 21">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="21">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110975981</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.</text>
            <dbReference type="EC" id="3.4.15.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 20 21">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="21"/>
    <dbReference type="RefSeq" id="XP_022084568.1">
        <property type="nucleotide sequence ID" value="XM_022228876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUN7"/>
    <dbReference type="GeneID" id="110975981"/>
    <dbReference type="KEGG" id="aplc:110975981"/>
    <dbReference type="OrthoDB" id="10029630at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.30:FF:000004">
        <property type="entry name" value="Angiotensin-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF27">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 21" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9 18 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 14 21" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 17 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 21" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 22" id="KW-0732">Signal</keyword>
    <keyword evidence="7 17 21" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034605708" description="Angiotensin-converting enzyme" evidence="22">
        <location>
            <begin position="17"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="13">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="15">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="13">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="15">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="14">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; partial" evidence="14">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18 20">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022084568.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="73477" checksum="35B468A4B47D3245" modified="2022-01-19" version="1">MAGGLFLASVVFAVRAFLTGGTHPMSQSGELIANETVAIAWLAKYDERAMEEYYHVTLKSWTFFTNISDANQQAMIDSNVKVAAFAKEARTNASRYDMTNFSYDTKRQLTKLKTIGDAALEDQAKLEELNNVLASMESRYSKGKVPKADGEYLSLEPGLTRIMATSRDYGELNWAWQGWRAAVGPSAKEDYQRYVALKNEAAAANGFSNCGDYWKSWYEVDDFTDQVENLYQQLSPLYNNLHAYVRRKLYNLYGADYINLKGPIPAHILGNMWSQSWLNILDLMLPFENAPSVDITPVLVREGYNAKRMFEVSDEFFESLGLIKMPPEFWAESMIERPTDREVVCHASAWDFYNQIDFRIKQCTDITMDDFITIHHEMGHIEYYLQYKHLPVLYRGGANPGFHEAVGDTLALSVSTPKHLHAVGLLDEVEDNKEADLNFLMSMALDKIAFLPFGYLMDKWRWAVFDGTITPENFNAEWWKLRTQYQGIVPPTPRSEANFDPAAKYHIPSDTPYIRYFVSLILQFQFHKAMCDAAGHTGALLKCDVYNSTDAGKLLGDMLQMGESREWPEALEKITGGRNMSAEPLLDYFEPLVTWLEEQNAGETLGWSEEWMPKEPPAWPPSGAAVTATQISLSALLVLTSLVLLLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV23</accession>
    <name>A0A8B7XV23_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 183B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110975507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM183 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083741.1">
        <property type="nucleotide sequence ID" value="XM_022228049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XV23"/>
    <dbReference type="GeneID" id="110975507"/>
    <dbReference type="KEGG" id="aplc:110975507"/>
    <dbReference type="OrthoDB" id="5955317at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026509">
        <property type="entry name" value="TMEM183"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20988">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 183A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20988:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 183A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022083741.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="53056" checksum="C4F1E8815864E71F" modified="2022-01-19" version="1">MPVERLEVEFQEDSFGEKRLRSAQHAAMPVTHRKHRRKRTSARREGSSKESSDSWQRSKLKGRNGRANLIFAHEKDVTLDAFADNASSRALAARVSKARATSINKEVKQVESASAILAAQGEADVVDDWYERNFSEDEESEKDATNDEAWGLGGDGCREKDAEMTVTSKEPDQQEQEDDHVTPAPQGKTTTCVYTGGQIHPSVIWYLVSFFINPEDVATFACLCRDTYALTNTAGFWRMLYFRYYNMKAAQSLPKELHPTSIQRTFGLRALVIRSLQFLYAPFVQRNAAKAAALLSSGDSLTNLVGRVFMYHVSKRKAGSHIYFLKFQERQSLDSGTLNAVEALNRDPDIHVNNHSGQSILRVICKQAHHLEPERIMGKELVRASVNISTGMSYSRLKLEFQEPAAGRGRAFNRSRFDRKRENTCIVLDPVVCARVFHWWDPNFHEEFRTNDSSVITNNINLDIWNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW07</accession>
    <name>A0A8B7XW07_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110976252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="RefSeq" id="XP_022085048.1">
        <property type="nucleotide sequence ID" value="XM_022229356.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976252"/>
    <dbReference type="KEGG" id="aplc:110976252"/>
    <dbReference type="CTD" id="23307"/>
    <dbReference type="OMA" id="NPSHIAN"/>
    <dbReference type="OrthoDB" id="77911at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056598">
        <property type="entry name" value="FKBP-15_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44927:SF1">
        <property type="entry name" value="FK506-BINDING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23649">
        <property type="entry name" value="FKBP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="211"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="306"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1125"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="717"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="858"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1132"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1160"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1172"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1199"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1213"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1227"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1287"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1302"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1366"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1401"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1456"/>
            <end position="1469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022085048.1"/>
        </source>
    </evidence>
    <sequence length="1469" mass="161932" checksum="E05AAE1D7A6CB510" modified="2022-01-19" version="1">MIGGRKRSMKGLRNRSGHALRAPVVATPFNRHERRSKLSSLFGMDRASNQGGNESLTYTAPKQPKKGTKGSKEGAAPSSSGGGQSALLLAVAVHAYRFSNGTYIKHGKLGAAILGNHTANDYKLLLYISKQQQVTHARITPHFIFTTQANNYATFYDEQRQNWSIMFETEQNAVDFAKQVGLAKLNASGGITKGVIQQDLTVGMGEPVNEGDSVEVKYTGWLYQSRTFGTVFDSNATVDKAFRFKIGRGKVIKGWEEGVISMKKGGRRLLLIPPALAYGKKGLGSRIPPNSTLIFDVEIKKIKVSKDETGSVSSDAMEAASALANEHHRAASPRVDSPRVDGASSSEEEEKMRTLSSTSQTKPPVPRKISINERVREKLSPSAPNQKRAGKPNRKVSSDETVKTRSASLTDHLSSSPVSSSKAKLISRMAKMGQPMLPLQGAAVATESTDDSEADENSASDTGYTSPPPVTAHPHPRSKPAKMGRKPPTTAKPEHQHAMGADGMAQQMHMPNSTVGMMPQTAQAMPLSQAVAVYQPQQQPPQPQQFPAQPQVQQQPMGMAGMAGMPGMAQQPGFQSTAMHGTGSQYPYQQQFTAQATDPNLLLQQQQQQQQAAAAAAAAAAAAQQTLHHHQQPQPQQQQQPFASTILTGTSQALVQQPVSQELPMLLSESRQHHSDLKMVMDLVSGKIDNLSARVEKLNFQSSATGPSPAAIPNLEANILMQNIARIVQENEKLKKENVEKDSKIETQNEKIAELIQRNQMFVEQSNTLMEKRNDSFKQTTAQSQARVLEMEQEKVQLTADLSKATAKISSLQMELSAVQQRESELKTKLDHGLNTSQSQLSEMEAMRTKQQDSDWKVTELTRNLKEEKAEKKSLSNRLIVIEEELNDLKSEKETIDKSLSERKRKAALEKQRFDDEIEELKKQYESIIASQIKEEISNLQNKLRLEKSSKDIATAEQIAQVERDLEAQWRERSERLLAQARDKHERLYSELNEEKETLAKKLAQTEQKMIALRSGQGETREEANRLKEQVSEMSGWKEKYDSLHSSAVSMKERYEDRIKEMIRDRETRDGAASHSNIIDEVKKIMNSVYHTLRSEFEPGGNYKGADILNTIMNTIKVVTLKLVKRSAGGSTEEEEDEDEGEESEEDEDSEEESEEDEETPVKPAKEVVQKSSPPVEEAAQASAPPSSQTPSGPGQMQDEPEDIPDLPDVPDEEPHGGESNNKDDGESSDEEGTSEEETAIEEAEAKEAGDTEDLEDAVPTETATEPSLPPEKSDEEKEEEDEGPTSLPPELPPDAPPEAPPSDEDAEDGEEEVDADEDVEENRAEEDAEPEAEVPEIPPQDTIDDLPDFSPQSETEPDDTTTESAPPPAMSPPPFLPSLPPELPPEDEDEPKTKSATDDIFGDDDDEDENEFFSTPPTKRKELLKKSSITKPVVKKDAEDGDSPKPQSPPPLFGSDDDDDDLDWLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXG9</accession>
    <name>A0A8B7XXG9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin lectoxin-Lio3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084952.1">
        <property type="nucleotide sequence ID" value="XM_022229260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXG9"/>
    <dbReference type="GeneID" id="110976181"/>
    <dbReference type="KEGG" id="aplc:110976181"/>
    <dbReference type="OMA" id="NEFIFEW"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034991476" evidence="1">
        <location>
            <begin position="26"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022084952.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27297" checksum="7A89ABA0EB8E47A8" modified="2022-01-19" version="1">MAWLTPNIGLKLFLIFSLPNSLALCASCPPGWLKWQQSCYIRLADKMNWFQAYEACDRPGSSLVVPNSPEENLFIWKSMVKGWGGLWIGCTDAAQEGVWLCGKEPAMYTNWHKKSPKFDDSLNCARVTVFQGGVWKNDLPCSTTQERRFAACEMTAAVVPTYHAAIDLDGRISPCLLHHEIKNVTAEGVLACGWACRAEPRCRSFNLWQGREKDLCQLNDVSRRGVSTKFKREDNCFFFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY31</accession>
    <name>A0A8B7XY31_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongin-B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Elongin 18 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">RNA polymerase II transcription factor SIII subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">SIII p18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Transcription elongation factor B polypeptide 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110976649</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterotrimer of an A (ELOA, ELOA2 or ELOA3P), ELOB and ELOC subunit. The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Component of multiple cullin-RING E3 ubiquitin-protein ligase complexes composed of Elongin BC (ELOB and ELOC), a cullin (either CUL2 or CUL5), a catalytic subunit (either RBX1 or RNF7/RBX2), as well as a substrate adapter protein that can be either ASB2, ASB9, ASB11, KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B, FEM1C, LRR1, PCMTD1, SOCS1, SOCS2, SOCS5, SPSB1, SPSB3, ELOA, VHL, WSB1 or RAB40C. As part of the Elongin BC E3 ubiquitin ligase complex; interacts with NRBP1. May also interact with DCUN1D1, DCUN1D2, DCUN1D3 and DCUN1D5. May form oligomers as a KLHDC2/KLHDC3-ELOB-ELOC complex; this interaction is autoinhibitory for the E3 ligase complex as the substrate-binding site of KLHDC2/KLHDC3 is blocked in the oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Elongin B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085803.1">
        <property type="nucleotide sequence ID" value="XM_022230111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XY31"/>
    <dbReference type="GeneID" id="110976649"/>
    <dbReference type="KEGG" id="aplc:110976649"/>
    <dbReference type="CTD" id="6923"/>
    <dbReference type="OMA" id="GQEQMDQ"/>
    <dbReference type="OrthoDB" id="7537057at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01788">
        <property type="entry name" value="Ubl_ElonginB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000108">
        <property type="entry name" value="Elongin-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039049">
        <property type="entry name" value="ELOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248:SF4">
        <property type="entry name" value="ELONGIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13248">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="18">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00093515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022085803.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13632" checksum="C6DCD1BA6D4A5961" modified="2022-01-19" version="1">MDVFLMIRRKNWTIFTDAKETSTVHELKRIIEGIIKRPPEDQKLFKDKEELDNTRTLGDCGLTSNTAKAQAPATLGLAIKLEGDTDEFETLDLVPYSNPPELPDVMKSSEPSTTNTVEPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYR3</accession>
    <name>A0A8B7XYR3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-crystallin 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086043.1">
        <property type="nucleotide sequence ID" value="XM_022230351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYR3"/>
    <dbReference type="GeneID" id="110976750"/>
    <dbReference type="KEGG" id="aplc:110976750"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086043.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23203" checksum="7FAD6F0EE020A24F" modified="2022-01-19" version="1">MPSYKVVYFDARGRAEPARMMLHFAGQKFEDVRYNAEEWAKHKPTTPFQQLPYLEVDGKIIPQSSAMQGFLARELGLNGANNEETTKIDLVGAVVADIVDPLTKILFYEKDEAKKKELSATYYGETAPRFLKGLEEILKTNNGGDGFFVGSKISRADIIFYVGMEAFRNDDVLKQYPKLYSLKERIAQDPKIAAYLKDRPQTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYT3</accession>
    <name>A0A8B7XYT3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Lethal(2) giant larvae protein homolog 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC110976179</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084936.1">
        <property type="nucleotide sequence ID" value="XM_022229244.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084937.1">
        <property type="nucleotide sequence ID" value="XM_022229245.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084938.1">
        <property type="nucleotide sequence ID" value="XM_022229246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYT3"/>
    <dbReference type="GeneID" id="110976179"/>
    <dbReference type="KEGG" id="aplc:110976179"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051294">
        <property type="term" value="P:establishment of spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032878">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000664">
        <property type="entry name" value="Lethal2_giant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013577">
        <property type="entry name" value="LLGL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF29">
        <property type="entry name" value="LETHAL(2) GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08366">
        <property type="entry name" value="LLGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00962">
        <property type="entry name" value="LETHAL2GIANT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Lethal giant larvae homologue 2" evidence="12">
        <location>
            <begin position="295"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="13">
        <location>
            <begin position="740"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="647"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="970"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1076"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1148"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="647"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="683"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="709"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="975"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1009"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1077"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1167"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022084936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022084937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022084938.1"/>
        </source>
    </evidence>
    <sequence length="1188" mass="130510" checksum="72FDA168D81C17E4" modified="2022-01-19" version="1">MASKIKGIFHRKPHAPSAERQRIQKELFAFNKTVEHGFPHKPSALAYDPKLKLLAVGTQSGVIKIYGAPGVEFIGVHEGESAVWQLFFLPEQGRIISLLQDNSLHLWEVNIKDGNSVLEEVKSFSLEGRLKKISVCCLSADCKTLYMGTEGGNIYLLNVATFDMDELIIYQDVVMQKLRDSSSSFSVPDDYKVNPGPVEAIAQHPTDDEKLLIGYNRGLIVVWHPKELTAEQTFVSNQQLESLCWHRDGLRFTSAHNDGSYCVWNAQESSQPEKEPVIPYGSKNRPIIDGEEMNGPFPCKAINKLKYLTTKSDPFMIFSGGMPRASYGDRHCVTVMQGNKHVVLDFTSKVIDFFTMSDVDAEYEFDEPHTLVVLVEEEIVFIDLQSEGWPVFNLPYLSSLHASAITCQQHVSNVPSELWDKIVAAGEQQMANNTSQREWPMNGGKNLAELPTPHDLLMTGHEDGTVRFWDASTVSLKFLYKLSTAQAFVTEADHADAGVGETEGEWPPFRKVGNFDPFSDDPRLGIQRIVLCPVSGSLLVGGTAGQVVILNIGTEEVEKTVESFPIQIVGEQDKFVWKGHESLGVKEDALKFAPGFQPSMVVQAQPPASITALALQTSWGLAGLGTSHGFALFDTVQKKLVSAHCTLNPNDLSSTGQPMTRKRSMAKSLRASIRRLRKRRDHRAGSPKKERAEGGASGSGEGVQTTDIDADKPEGKEDSGAKSSPTREMAQVERKIEARSDDTKTSMVRCLYFANTFVNDSQVATPSLWCGTNAGSVIIYVISIPGADKRDTDAVEAMISKEIRLKHGAPVVSLVIVDSDTYPLPDPIDVQNERAKPPNMSGHSLIVCSEEQFKVFHLPSLKPFRKTKLTAHDGSKVRKVSYINFRSRSDDNYSENCISCLTNLGELAIYSIPALKKQLGFSALRKENVAGIQSLIFTSRGEGFYLLSPSELERFSLSARYFTEPMCMLELPEGMRPPPPEPEPEPAPQEPEAPVDGHPIAEEAPPAEEPAAVAEEAAPAEESAPPASDDAAPETRTETTTVVVQETDMDDPMMIQSGTTVKTVKTSSTTVVKTERTLISSSSSGDQKVVKTTEETVITSGGDHQTPEELHNEVDELLAKIPNISVNLEGDTEENPDITLDEVREYGKDEQAAGEVHSGDASAEVNHAADERREGKGVVELQIREETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4I7</accession>
    <name>A0A8B7Y4I7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088104.1">
        <property type="nucleotide sequence ID" value="XM_022232412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4I7"/>
    <dbReference type="GeneID" id="110977887"/>
    <dbReference type="KEGG" id="aplc:110977887"/>
    <dbReference type="OMA" id="TEDERCC"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="28"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022088104.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="54218" checksum="4B6CF751649FA128" modified="2022-01-19" version="1">MKQASRSEAPRRRPPAGEIPDPPEARWGVVVVVASHLNVALLIGLVRCVGIFYQSWKQEFETSAKQTAAVQSVMTSFSAFGGIIGGILTKRQGCRRCGILGGLLATCGLLSSHWVSSIYQLYFTAVLTGTGIGLSYTAAIVIVALHFKRKYKTANAVAFSGSGTGLIAAPPLMQALLDNFGWRGAVLISAALMANAVAFSTLFRSPLRAERPNRASNATVEQVDSPECGDDPILDHARDTFEEVPRTEDERCCDATDELEILSEGNHVSEVTQGNRDGYAPLKDSKRSRHAVGVTLLKRFSETFGLNILIRSYRFALLCLLQFEFSLSYLGFLQFLIPRAESAGVASQDAAVLLSLFGVGILLGRLVNGVLISWRLAAEHVTTAGLALAGLTLLVANVDSYAALAVASSVQGFAVGFLVAVMVVLTRRFVGMANFAVGVALCSFSVGIGVLTGPVMAGWLLDATGNYETVFYVLAGWYFLCAVQMLFLPLLKRHEPGIDIQPSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4Q2</accession>
    <name>A0A8B7Y4Q2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein regulatory complex protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">IQ domain-containing protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110977936</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRC9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088174.1">
        <property type="nucleotide sequence ID" value="XM_022232482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4Q2"/>
    <dbReference type="GeneID" id="110977936"/>
    <dbReference type="KEGG" id="aplc:110977936"/>
    <dbReference type="CTD" id="69707"/>
    <dbReference type="OMA" id="ESKMHFY"/>
    <dbReference type="OrthoDB" id="10254713at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23766">
        <property type="entry name" value="IQCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042618">
        <property type="entry name" value="IQCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14871:SF1">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="170"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="242"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022088174.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="45704" checksum="DF7B68D5BE9FB57F" modified="2022-01-19" version="1">MSELTDLDSVYITTVLEDTVDQLAILGKIMPQTFEGRADASEMVGDEIGKIIDSQKQLESKYEGLIAKRAELRAGGRKGDANHLKATEEEISSVVGGIRHATQTFSKSLKQSPLTSDNLAKMQVDRQFLQDVLSEAMEEITLEKTFTSLIQSVTAERDKKAELQNTILKEEEGRKRIRSLQRQIQNVKVELEEETQQRNEMIAHLKDQLQEMKAKTSMEGKYVQKDAEVAVYQVQKRCMLSEKQLKDEIELIKKKIDEEIRVNQEIEQYLKAHQTELEEKVDYWMEKYDKDVDQKTHQLEVLKASKANDLSRLQELTRLYAEYEQVVVEDRIEKEKIRRLQEQELEELKSTVKLQSWWRGIMVRRQLGPYSKKKKKKGKKGKKGSGKKKGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y526</accession>
    <name>A0A8B7Y526_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110977273 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110977273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086946.1">
        <property type="nucleotide sequence ID" value="XM_022231254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y526"/>
    <dbReference type="GeneID" id="110977273"/>
    <dbReference type="KEGG" id="aplc:110977273"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03467">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007402">
        <property type="entry name" value="DUF455"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054716">
        <property type="entry name" value="Sol_Rieske_ferrdox_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42782:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42782">
        <property type="entry name" value="SI:CH73-314G15.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04305">
        <property type="entry name" value="DUF455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22543">
        <property type="entry name" value="Rieske_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022086946.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49587" checksum="ED80E0B40801366C" modified="2022-01-19" version="1">MEGGFEVDLVTALKDVVDSSRWRCVGHTDLFKGKTCTRLYSLGGEEDVVVVRLTPDKFYALGADCPHEGGPLDLGDIEDIDGHMCIVCPWHDYDFRLDNGDSTSGLKQQTYAVKLVDDQLYINTSLDLSHTKSSEKQLDKKHEAEQQLRSCSEGEDTLCSWAVKILCTADPNEKVRLTHEIQERWQRGDLTEVGRCQPPDQPHRVESLNVVAPGKIKRGKAGTLGNRIALLHSLANIEQWAIDLSWDIIARFADTTLGDRSHLPKDFFTDFVKVAGDEAKHFTILENRLQALGSHFGALPVHNGLWQSATETKHNLLARLAVVHMVHEARGLDVHPKTLEWFSKQGDDDSVAVLDVIYADEITHVAAGMRWFTYVCRHAVPPLECISEFQKLVRKHFRGLLKPPINEEGRTIAGMSKEWYVPLMQPASRDADGEDSTTSVGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y620</accession>
    <name>A0A8B7Y620_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UBX domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110978175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088649.1">
        <property type="nucleotide sequence ID" value="XM_022232957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y620"/>
    <dbReference type="GeneID" id="110978175"/>
    <dbReference type="KEGG" id="aplc:110978175"/>
    <dbReference type="CTD" id="51035"/>
    <dbReference type="OMA" id="AQHFPRK"/>
    <dbReference type="OrthoDB" id="10254930at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903094">
        <property type="term" value="P:negative regulation of protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14302">
        <property type="entry name" value="UBA_UBXN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01772">
        <property type="entry name" value="UBX_UBXN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000134">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041923">
        <property type="entry name" value="UBA_UBXN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46340:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="353" mass="39224" checksum="70B5C6F1B1951D70" modified="2022-01-19" version="1">MCSTRIGGVSVLPAVGSGVVKEGDHTLTRSPSDSGTKILKEGIVDKESHGIIYSWRSRFCILTQDSLTIFRSDPRRKGGGVAEEDKRRRASSISERAEKKNILYRLPLEEISSMSNIDKGRRHIHFTICTKQGVFALRVNLGQRDWLTQIQLAVADRRSRNDFMRELKTRTSVVANKYRKHNHRRLSFSKEEDYGDGIGITIRNEADSIVIARIFADGPAAKKGTLRPGDEIVEVDGKPVRGYNAERVAGLIKGMPGHVVLTVKPTWVDRGTNTSAADFALSRPLYPKPNNLRGRARPHSLADVAVSTDPEVPSATNVVNDVSSMSPIDRKKFTRCPVKNKNKETSENRLSLP</sequence>
</entry>
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    <accession>A0A8B7Y793</accession>
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            <fullName evidence="8">Collagen alpha-1(I) chain-like</fullName>
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        </source>
    </evidence>
    <sequence length="1417" mass="132336" checksum="3574998D7BD7B1C5" modified="2022-01-19" version="1">MYSFVELTSRYRRLLLVFVVLFMVANAQRAPSKLVGQKGDRGQKGEPGAPFVAGSGIGGGITGPPGAPGPRGPTGPRGDSGNSGPQGPQGMKGDPGVRGMIGLPGPPGKPGPPGSPGTISASANVGQQAYKGVLPGGYQYPQASVQGPPGPRGLPGSPGQRGAQGMIGPAGPTGEPGSPGPAGPAGPPGPPGRNGNDGDDGKDGSPGPAGPPGGTGARGAPGRPGSPGMKGHAGFAGLPGMKGDTGSKGDRGADGATGPSGAPGLPGPAGPQGERGRTGSQGEQGPAGADGSPGSQGPSGPPGPTGAPGMPGIQGPKGDAGSQGGRGPQGVQGVRGERGSDGSPGAPGAPGSPGRDGSVGAKGPAGAVGPMGAPGFQGPTGPPGPAGAVGAPGAKGDQGAPGAPGDRGEDGPQGPAGATGPQGAPGEAGQDGPRGARGSPGATGPIGPPGERGAVGPMGPAGAPGAPGPKGNLGERGPRGEQGAKGNDGEPGRPGEPGIAGPRGLTGAPGKEGRDGKPGPPGPSGDDGRPGAPGAQGQRGLPGIQGLPGTTGSPGDRGADGAPGPQGAQGATGEPGKQGNPGPAGPAGATGATGDRGPAGAQGPAGPMGPPGPTGVPGDAGPAGDVGAPGDSGPAGPIGPRGERGSQGERGPPGAIGPPGKRGTSGRSGSDGRKGDVGAKGDPGLQGPPGPQGAPGDRGPAGPPGPAGPTGSVGPTGAPGPSGSDGAIGPMGPVGPSGAVGMPGEPGDQGEPGPAGAPGDRGDTGVQGAQGPPGPQGFAGGPGRPGAQGPRGPDGPSGDKGEPGPAGPAGAPGDVGPAGAPGATGAPGDRGETGAQGAQGPSGPMGPVGAPGLAGPQGSAGPAGPAGNDGAPGPRGESGATGRPGEQGPQGLPGPPGDRGDRGGDGATGAPGPPGPAGPAGQIGNLGVNGAPGPRGPVGAPGAQGEAGRPGNDGSPGERGAPGAPGAPGPAGPPGDAGAPGENGNDGATGATGPRGDKGDQGPTGSQGAPGAPGIAGAPGPAGSAGDRGDTGAPGPAGPAGPAGQRGNTGSAGPAGPAGPAGDRGATGAQGAKGHPGMPGLPGIQGPPGIAGDSGPAGEAGAPGPRGAPGQRGANGKDGAPGGRGYVGNEGPRGPRGEDGPQGPAGPPGPPGPPGPPGEVQASYGLSYPYAVGSVGKGADPYAGYYGDAATKAKAKPMDNREISLVLASLDKQINDLKKPDGTKANPARTCKDLFLCNTEFTSGYYYIDPNQGCTADAIRVYCDKASSESCVEPKVAEYEKRRWHVGPPKTVYMNSVNSGKMIEYNVTDLSQLTFLRLLTTTVSQAFTYHCLNSNANLKLLTSIENIELTEDSEDPKNQYEVEEDGCSVKDGEWHATRVSYTTSTRSSRLPIIDVATSDVGGADQQFGWEIEPVCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8Z7</accession>
    <name>A0A8B7Y8Z7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vasohibin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110978374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089017.1">
        <property type="nucleotide sequence ID" value="XM_022233325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8Z7"/>
    <dbReference type="GeneID" id="110978374"/>
    <dbReference type="KEGG" id="aplc:110978374"/>
    <dbReference type="OMA" id="MWRHVAK"/>
    <dbReference type="OrthoDB" id="9974232at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028131">
        <property type="entry name" value="VASH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15750:SF2">
        <property type="entry name" value="VASOHIBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15750">
        <property type="entry name" value="VASOHIBIN-1-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14822">
        <property type="entry name" value="Vasohibin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR628131-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022089017.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43661" checksum="7140A0F0DBBE8CEA" modified="2022-01-19" version="1">MRECQFVHLKMTGKSLEVSLTKAKADNPTKSGADDDSNDEENGVLFYVNKNGFPVSKSTWERMWSHAAKVHPEGSVPMAEIREQKDLPKVNIPPAPTFQPTTAVPCRLEAVQDYMKELQYNHTGTQFYEIKKNRPISGLMDTAKEMIRESLPIKCLEAVILALYLTNGAPGLERFPVSFKTLFSGTVHRHVVLGVYYSGRYGALGMSRREDLMYKPLEFRNLWELIFDFEDAYKKYFHTVKKVKIGLPVSHDPHSFEQIQWRTMSLSPGKQSRLEMQREIEKFTKDLKSRFKWSSNYSSYQFVKENTRPSYESTSPRKSMGPSVAARTQRRDCHQQTSGSTEASLSPRAVMAYDSSDEEAEECSPASKTASKKGGTTGAYQIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y990</accession>
    <name>A0A8B7Y990_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon catabolite repressor protein 4 homolog 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088291.1">
        <property type="nucleotide sequence ID" value="XM_022232599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y990"/>
    <dbReference type="GeneID" id="110977997"/>
    <dbReference type="KEGG" id="aplc:110977997"/>
    <dbReference type="OrthoDB" id="10253982at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF98">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088291.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45101" checksum="385346FE39DC4F11" modified="2022-01-19" version="1">MSLSANLQREWVPNQTLPTAGLIVGDFVVMTYNLLNKDLGPDGLFSYCPDELLSTARRHPVLMGEIDHHKDADIICFQEVSSLYYDETLVPDMHERGYTGAFIKRPSARSADDKRPWTDGSATFFRSARFQLVKQEGGHFKDLFEKEQEKLQSPTNTTSCDPDLIDSKRSFLFVLFRCLETDRLVAVGNVHLTCVYGSYNRMDLNSLEAAFALRELVRFCGGADAPHILCGDFNFEEHHPGYQLMRDGLLSEASATYLRNLRLPGEKDGSKNVMSLLDVFPDFFTHDSVSLKSSYKTVMGHEPPFTCYEDSSPECATPVGPLPTKALQALFDVALNYTKQGRGADKYVAAVDYIWFSSSSLHCSGALRMPEERLILPFHACPNAVFPSDHLLMKAQFSFLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBS4</accession>
    <name>A0A8B7YBS4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110978946 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089997.1">
        <property type="nucleotide sequence ID" value="XM_022234305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBS4"/>
    <dbReference type="GeneID" id="110978946"/>
    <dbReference type="KEGG" id="aplc:110978946"/>
    <dbReference type="OrthoDB" id="10624190at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="603"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089997.1"/>
        </source>
    </evidence>
    <sequence length="971" mass="107801" checksum="099B1B520FF93C82" modified="2022-01-19" version="1">MVAQPAQLVLYNEGGADIPSSRLNQEPITPVVHIRTEEDSPIQLTVSQGPTTAPPSRHLPIIGPPSPRKLTGKYRQIPSIKVSPLRHRNTTMLSRKPLNNLVWGEILPDKPRLQQFKPPSEKDQQTGKLTRIPVQNLKEEHADFTPEDLADLSIEAILAITGISLGDEKPTQSATKEESDGCFVVRQVVVWADDSGGRQREKDSPVADSCLLSVTKETNPSKDLPHDHKDDGKVLDLIEDSLFGDELDEEGEDSTDRSPLEDPPITATNQPRFPPRLPPLRPKCDLEPNKSYGKKMTKRSKQKQRQNGDHGLLKGPFLKESDSKFESEESRLNSKGYNCQLSSNNNGSTEDLHRNRAGCTEVPKPSQGSLDSILQMMMTNLVPDDYTTEATVAKAANSFSVPPVSAPAVKVAQHATPTVSIPLGFGIDKLQDESKITLTGPQDFEAGVTNCPADLTMIETSYPPTGFFLKVRPSKVSTVPPPPGFLRQNVQSGSTQSEESNVEQTNGVDEKCQDGTAVSQNHHSSEDWYYKVPWPADWKEKNRDASHLPAGLRKALHIDLSWLQQDGDDKPKLKPGGSNMNTDDTKAIKGKMADKVQQMRNGNNNHILSNTEASKDTQCKRKPTWPNSSGTDLRNLTSISSSPTDLGRTTFLSIGSSDNPCSENRNQGSCYISNLSISTRSDSLLSQSSLTSWGLDVDELILLLSDDDSECTSDDFLSDDVTFVCENYGTVDHSQHHPKSLQSPLLSPDIVSPFCLTLANGEHDVFDLRQDSNNRRYDPRRYIEEDIFLKPPTESRDSLDRYLSEGTWTDHELEYIFKASVVKKTKFQLNHSRNAEITITGGIAEKRVPDNVTYRISVRSTEIDDAQLLVEDKNPNPRLDIAATDDTHSLEVQSQQRTDNSSLQPALDVEKWMRFHDAQMEQAIRMERLAGGRSVSAPQLVTSDNSYDRVIDWVRTSDFSLAPSRGKDEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YC24</accession>
    <name>A0A8B7YC24_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gamma-butyrobetaine dioxygenase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110978498</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089236.1">
        <property type="nucleotide sequence ID" value="XM_022233544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YC24"/>
    <dbReference type="GeneID" id="110978498"/>
    <dbReference type="KEGG" id="aplc:110978498"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008336">
        <property type="term" value="F:gamma-butyrobetaine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
        <property type="entry name" value="GAMMA-BUTYROBETAINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="11">
        <location>
            <begin position="145"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="259"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022089236.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="59152" checksum="3CA3C3016DED82A3" modified="2022-01-19" version="1">MPPSPLEMYNKFPRRKCGGRAVRVIIIILSSVGTTESFQAKMTARFVGCALGQDFSSALARRRSGLMVSAIVNTLSKSSQARRAQPWLVPESSRSKTALWKASAKPYSTQSPQMLVTVPPQPLTKETPSPASGQNGFKTLTNVEVDTEKKQLLVSWEGGAASQAFPFVWLRDNCHCPDCFHPIALGRLPSAQVVNVDVVADSAELSADGTKLTVQWDDTHKSQFTTDWLRYYRFDKSPDDQLFNPKLSFFSADAFPKCFDFGELLADDRILYGWLSEVLKRGVAVVKNAPAEIGQLQKMGERVAFLRPTLFGVTSCVKSELKPSSLSYTSDGLATHIDYNYYMRQPGFGMLHCIEQAEGEGGESLISDGFKVALDLKEIDPEAFRLLTTYQFEYSEKGTDFFGRFYLHSRHPVIRLNERGDIEAISISNHTRDPMLRVPVDQVLPFYRALDIYFKMLQKPENLLKYKMQKGDILSFNNRRVLHGRNSFTLTENSVRCLEAGYLDWDEINSRLRVLAMKLENPANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDM4</accession>
    <name>A0A8B7YDM4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Riboflavin-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folate receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090475.1">
        <property type="nucleotide sequence ID" value="XM_022234783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDM4"/>
    <dbReference type="GeneID" id="110979188"/>
    <dbReference type="KEGG" id="aplc:110979188"/>
    <dbReference type="OMA" id="LSNCTWY"/>
    <dbReference type="OrthoDB" id="5982264at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004269">
        <property type="entry name" value="Folate_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517:SF28">
        <property type="entry name" value="COILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10517">
        <property type="entry name" value="FOLATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="5">
        <location>
            <begin position="38"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022090475.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="21064" checksum="03CE4100C7947675" modified="2022-01-19" version="1">MAVIIRHWISTVRLFLILFVSYVVGQVCTYYGNYRYAEQQSNLSNCTWYRDMACCRRTEVSSVFGSMFKIHGESRQCKSRLNYMMCYFCSPNQVDWYDSKVVICSDFCEETFELCKDARLEDNSIGEKFESGRHFCEANNFEVVPGRERCFNFDPSAFDSAVSIQPGIVGLFACLCIALLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE80</accession>
    <name>A0A8B7YE80_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Uncharacterized protein LOC110979416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110979416</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090881.1">
        <property type="nucleotide sequence ID" value="XM_022235189.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090882.1">
        <property type="nucleotide sequence ID" value="XM_022235190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE80"/>
    <dbReference type="GeneID" id="110979416"/>
    <dbReference type="KEGG" id="aplc:110979416"/>
    <dbReference type="OMA" id="VVEAFMY"/>
    <dbReference type="OrthoDB" id="6429478at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050532">
        <property type="entry name" value="Globin-like_OT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458">
        <property type="entry name" value="BLR2807 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46458:SF1">
        <property type="entry name" value="GEO09476P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="140"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="302"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="466"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="626"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Globin" evidence="7">
        <location>
            <begin position="786"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022090881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090882.1"/>
        </source>
    </evidence>
    <sequence length="935" mass="103655" checksum="8057AC928B9DA082" modified="2022-01-19" version="1">MGCVESSNQSPAKRSQSTASHGARHNGSRAKASQTRQGVRQMNAFMKTVDIATQTEETAGLLLRRLSSRIKQRHRRSTRGQNVEPPDRSLLFDLNRSVALTHSKVADYIDQALAMPGERRGPDAGQSVPNGTIATSDQGPLSDRDKSLVQGCWKEVRKDLVELGVDLFVRLLEDYPTLRDLFPFGKLNLSTEKLRHNQDLRGHGQRVMETIGTAVEGLDEWELIVPLLEDLGARHKGYGAAPEHFVPLEEAFMFSMRNGLPPKVFTSEVQGAWKNFWKAVIEIMSETMRTGRGFVENHDEGPISPRDKRLVQGSWKAVEKDLDNLGAALFVRLLGKNPAIKYLFPFGKLNLSPENLQHNPDLRAHGKGVMETIGTAVNTLNELDKLVPFLKDLGARHKAYGAKPEHFKPLAEAFMLTLKDGLPPKVFNSDVQGAWENVLQVVAEVMSSTMRTDSVENGPVDGVEGPVSSKDKQLVQESWKIIQKDLVNLGAVLFARLLEKNPSVQKLFTFGKLNLPPEKLRQNPDLRAHGKGVMETIGSLVTSLDDIDKVVPMLEDLGSRHKIYGAKPEHFPAVVEAFMYSMKNGLSPKAFTSEVQEAWRNILKVVEATMGSTMRSDKDGVSDKKFVSQRDQKLVQGSWKLVQKDIVNFGAVMFARLLEKNPGVQKLFTFGKLNLPPAKLQQNPDLRAHGKGVMETIGTVVTGLDDLEKIFPVIEDLGARHKMYGAKPEHFPAVVEAFMYSLKNGLSPKVFTSEVQEAWRNVLKVVDVVMTGAMRMDENGNVGDGPISSREKELVQTSWKIMQKDSVNLGAAIFARLLDKNPSIRELFPFGKSSVPLQMLKRNPDLRAHGKGVMETIGSVVAGLDDLGKIVPVLKDLGARHKIYGAKPGHFKPLMEAFMYSARNGLPPKAFTSDVQEAWGNTWKVLAGIMNTTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFH6</accession>
    <name>A0A8B7YFH6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Retinol dehydrogenase 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110979559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091155.1">
        <property type="nucleotide sequence ID" value="XM_022235463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFH6"/>
    <dbReference type="GeneID" id="110979559"/>
    <dbReference type="KEGG" id="aplc:110979559"/>
    <dbReference type="OMA" id="WGPAQVI"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF86">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034128341" evidence="4">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022091155.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="32382" checksum="9B621F7D42483F49" modified="2022-01-19" version="1">MAPKVVLITGCSCGLGLAEAVLLSTRFKHDFKVYATVLKLSDKGDLEAAAGDAINKNLFIREVDVTKTETIKALVDEIIRDNGRIDVVVNNAAVNGIDDPFFAKPLGSLDQAQAMMDVNFWGPAQVIKAVLPFMQEQKSGLIINTTSESGKTESPFIGLYAATKCALEGLSESLALVLRKAYNIRVVILEPGTFTSPMVVYSLSPEFQPEFLTTKWEESAKGMFSEFWHRDMRRLMMENQAPEEVARVVEEIILCDEPHLRYQSGPIITQRLARKLRDPTGDSAFKAFQSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFW6</accession>
    <name>A0A8B7YFW6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Roundabout homolog 3-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110979740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091482.1">
        <property type="nucleotide sequence ID" value="XM_022235790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFW6"/>
    <dbReference type="GeneID" id="110979740"/>
    <dbReference type="OMA" id="CHIENGD"/>
    <dbReference type="OrthoDB" id="6085115at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034901905" evidence="8">
        <location>
            <begin position="31"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="46"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="153"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="235"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="328"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022091482.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="62998" checksum="C00509AFE51DB9F7" modified="2022-01-19" version="1">MAFGIGINTVLLRLASLAFVFMATLHSAKSLELEVEDDNRYPVAESDVVLTCYGAYDGILTFSGNPQGKVVWMKDGQPIAEWPKPAGTETPTRYDLSADAPEDGAVYAYLTIRSMDTTDNGAYRCQLLRGETVLGTSYEVRLTVEQRPASEYPKCSVLTLSNEQVFLCESERGSPPVSLQWWKGEQPLNKTDLDVDGFVQARFAAGEEDESNAGRFECSLTFREQRTGSCVLDRPSVAIPAPTSGLLLGQDLIVVCVTSGNPPVSIVDWDFKPSLFSSFGKDGNTLTIYNISSRDNGTQIICEGHNALGSNQASRVITLRPLEATVQPITVQLEQTKVPTSLDEQAQFKCVTTPPRSPPPPCIWHYNGEYVDPDNTSDRFLVEDRSEHVLSVSSVTTMDVGASVTCHIVVSYRPNAEVFLRATFPQTTKAGPVLTTTRRSPKSPSLPGKPWPVSTLMGYIIGGLMCLVLVGICCWVSLKAKSLLRSKRYASNDGKPMTRTKASCNRLDNDFIVDIGMPPELTARPSMVTKMALAEEESPYQDLEDVSRQRQTNEYQRLISNDWTPDAPESSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGE3</accession>
    <name>A0A8B7YGE3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Leucine-rich repeat-containing protein 45-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11" type="primary">LOC110979727</name>
    </gene>
    <organism evidence="7 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091462.1">
        <property type="nucleotide sequence ID" value="XM_022235770.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091463.1">
        <property type="nucleotide sequence ID" value="XM_022235771.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091464.1">
        <property type="nucleotide sequence ID" value="XM_022235772.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091465.1">
        <property type="nucleotide sequence ID" value="XM_022235773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGE3"/>
    <dbReference type="GeneID" id="110979727"/>
    <dbReference type="KEGG" id="aplc:110979727"/>
    <dbReference type="OMA" id="EVDHMTR"/>
    <dbReference type="OrthoDB" id="8436363at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052116">
        <property type="entry name" value="Centro_Cilium_Assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23170">
        <property type="entry name" value="NY-REN-58 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022091462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022091464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022091465.1"/>
        </source>
    </evidence>
    <sequence length="693" mass="79003" checksum="E53CE111F0FDD3E0" modified="2022-01-19" version="1">MEDFRTSYLRLCKENSLEPQQSVLSRLSHTKQGQTAVGKSPRGTPSAKVAQGSHGAVLDLSTTSLTVQTCSVLGAALAKDCLVGELRLSDCMIGDEGFKLLGHGLCSNIAIRNLDLKGNNLRGASAEALGNLLQQNHSLRRLCLEWNSLGLDSDRFAFLAEGLAANNSLEMLDLRNNQLSHDGVSELSKALHRNCVLRSLDLRWNNIGIVGGRSILAMLQYNKTVTELELAGNNITQDILKAIDVARQHNVDRASLTNEHETRQSILAREIKQLRTEKKQQASDLLHRIDQQNEFQSRTHRDTAYKIHQLQEALAERKSAFNALNAKLSKTEAELVLAEQRSRDLSDLLEVSRRENSVLVAGHQKEMQIQLGDKASSESKLLHEIASLKDRNLHLETKADELDKRGQHQQDQIYELKEELATSHAQTKLQATQAEERLQNEKQRLRDQQRDLEHRHTTEMQHQREAAEESERAYRDRISKLEEHRRILEEEMSKAKNQQLTERLALEEQILSTRQRVKEEEHQRMKHLEDKIRLLANAKDDIQQHHSQQLQTIAELQAKNSNAALEVESLKRRLEEINQELAGKNNELQTEVNKVKLSCSKQLSKMEARVQDAESLRERCSALELQLAEQTRRHRTELMDRDNELEGTKEKMRSQEMDFCRMQEEEAQRAGMLQAAISGYLTTSRTPLSTPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YI61</accession>
    <name>A0A8B7YI61_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 11, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980189</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in mitochondrial morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM11 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092297.1">
        <property type="nucleotide sequence ID" value="XM_022236605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YI61"/>
    <dbReference type="GeneID" id="110980189"/>
    <dbReference type="KEGG" id="aplc:110980189"/>
    <dbReference type="OMA" id="IGNCLHK"/>
    <dbReference type="OrthoDB" id="9970856at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026120">
        <property type="entry name" value="TMEM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099">
        <property type="entry name" value="PROTEIN PM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14972">
        <property type="entry name" value="Mito_morph_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022092297.1"/>
        </source>
    </evidence>
    <sequence length="176" mass="19661" checksum="9FD7E8C199D83631" modified="2022-01-19" version="1">MAETEREALPTDCAIIHEIYDNGDAQEQFEYELEQALESGRSIIIIEPSRLGDETARWITVGNCLHKTAVLAGVACLVSPWMLPAKAVNFISVPFGATSAACAALYGVSWQFDPCCKYQVEYDTRSLARLPLHTLTTATPVVLVRREDKYRKALHNVIAGLAAVYLAYRFYRWCAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJA9</accession>
    <name>A0A8B7YJA9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Enoyl-CoA delta isomerase 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">3,2-trans-enoyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110980386</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Key enzyme of fatty acid beta-oxidation. Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs. The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(2E)-tetradecenoyl-CoA = (3Z)-tetradecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:29847"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
            <dbReference type="ChEBI" id="CHEBI:61968"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:29849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(3Z)-decenoyl-CoA = (2E)-decenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:77195"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:195601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77196"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3Z)-dodecenoyl-CoA = (2E)-dodecenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:23716"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:58543"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(3Z)-octenoyl-CoA = (2E)-octenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:46044"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
            <dbReference type="ChEBI" id="CHEBI:85640"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46045"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092707.1">
        <property type="nucleotide sequence ID" value="XM_022237015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJA9"/>
    <dbReference type="GeneID" id="110980386"/>
    <dbReference type="KEGG" id="aplc:110980386"/>
    <dbReference type="OrthoDB" id="1696280at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000034">
        <property type="entry name" value="Enoyl-CoA delta isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF45">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022092707.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34697" checksum="DDA872C81A613CA9" modified="2022-01-19" version="1">MDALHAVGKKAGAHLLLRSLGASTLCRSKAGAAPLLLSQQRRHYADPGKYIQVERDIVCEDIAIVKMNKKPVNSMCGDFMRELSVTLEKLRNNETYRGAILTSAKPGIFSAGLDINEMYQRSTDHISVFWRTIHEFWLGLYGTDLAMVAAINGHAPAGGCLMALSCDYRIMSQGDYIIGLNETQLGILPPFWLQELMARACGDREAEMGLQLGTLYTPEEALKIGLVDEVAPLDSVVDRAREQVIKWLKIPDYARVVTKGMQRGPLLKKLQASQEEEVAFNAEFIHRESTQDVIEKYLMSLKKKKKKVDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJI9</accession>
    <name>A0A8B7YJI9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 241-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110980431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022092787.1">
        <property type="nucleotide sequence ID" value="XM_022237095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJI9"/>
    <dbReference type="GeneID" id="110980431"/>
    <dbReference type="KEGG" id="aplc:110980431"/>
    <dbReference type="CTD" id="338363"/>
    <dbReference type="OMA" id="WAIIHLF"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092787.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39339" checksum="CBF9544F444AAFDF" modified="2022-01-19" version="1">MSFTWRAWCRCPVKSLPKLWRQGICMVFFLRHNSSNCMAAWSLIGVYCVLFVATNITNKYVLSVLHFTYPTLFQEWQTSVGVIVLFVAANRGFIKLTYDRSALLPWLPAMMFFVGSIYSGSRALSKLVVPAFVIIHNTVEFPAYIVGILINNQAFSLANIASMAAGTFAAILTWVTDPQRDEGSYEEGYFWMLIYVLSASSFAIYSTARGSAINLSDVEKLFYCYFFSAVALSPASVILGDIVAAREFPHWFLYRFYIGCILSGVLGAAMNLTGICVSRCPSPSLLSRLAIANAKTVLILVSLAIFEGMFTGDFALSVFLGVTAYSVYTVTKTTSNTLATNDVGEKLEIERHENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKW9</accession>
    <name>A0A8B7YKW9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Vitamin D3 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110980567</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093074.1">
        <property type="nucleotide sequence ID" value="XM_022237382.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093075.1">
        <property type="nucleotide sequence ID" value="XM_022237383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKW9"/>
    <dbReference type="GeneID" id="110980567"/>
    <dbReference type="KEGG" id="aplc:110980567"/>
    <dbReference type="OMA" id="TIHFAKT"/>
    <dbReference type="OrthoDB" id="6352325at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06929">
        <property type="entry name" value="NR_LBD_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF507">
        <property type="entry name" value="BILE ACID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="385"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="111"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022093074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022093075.1"/>
        </source>
    </evidence>
    <sequence length="614" mass="66607" checksum="CCC67433D66EF4C7" modified="2022-01-19" version="1">MADVQTEADISSAKKKATESSASKEERLCLICGDRANGVHYNVLSCEGCKSFFLRSTKSKATFTCSQGGKCSMDLYTRRHCPACRMKRCVELGMSVDRVWDEDRLKTRKRLIRVKRKKKQPISDPNHTSSAQRSMTSPSTSTKTSAANSPAPAPVTPTLTPNLTPVTTPGVTPGTESALSPGANQVMTPDIAALMSSVMMPGFDLNTMQSLTPTVPEPQWELTEEQQNLVERLEKGYLASKEVFKNIFPKAPGSIPIPEGTNGNHGSSIFAPPTTAAALTVDATSSNVEAPAPTTSSPKNPLNALTSLLPEGMTPAKALTALATGELNIPERFSLGDLLPSGLSSIASSLLCSDSIPMPGAAADKDSLGDGTSDPEKKEAGPYQSIQRVTSFITNGSMKESGPPPEKPKLPIHKELLHTAMDMFAILVKQTIHFAKTIPGFMDLMCDDQAVLIKASIMDALLLRCAESYVPDMGCVINEMTNDLFHINMMYQMGYTSLPEQAFQFMKETKECGLTTAEYALLNAVAILSPDRTELQNRELVEEIQLSIVETLHAATKVFHQEDRTLFAKLIMKLTKMRDIAVVHLSDLMEVQVQERDLSPLIIELFGLDTSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKX5</accession>
    <name>A0A8B7YKX5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110980696</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022093287.1">
        <property type="nucleotide sequence ID" value="XM_022237595.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093288.1">
        <property type="nucleotide sequence ID" value="XM_022237596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKX5"/>
    <dbReference type="GeneID" id="110980696"/>
    <dbReference type="KEGG" id="aplc:110980696"/>
    <dbReference type="OMA" id="YINFFDM"/>
    <dbReference type="OrthoDB" id="255819at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022093287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022093288.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13453" checksum="5F5813D0360AB37C" modified="2022-01-19" version="1">MPMLEINTNLKEEDIQPDFLVTTSKLFQEAIGKPMEYISVHLRPDQLMAFGGTNEPCAFVNVVSAGKISPEENIKYTKLITQIMGKLGVPPDRMYIIFHDIPRDNLGFKGSILSDLVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLF7</accession>
    <name>A0A8B7YLF7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">GDNF family receptor alpha-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110981131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDNFR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094099.1">
        <property type="nucleotide sequence ID" value="XM_022238407.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094100.1">
        <property type="nucleotide sequence ID" value="XM_022238408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLF7"/>
    <dbReference type="GeneID" id="110981131"/>
    <dbReference type="KEGG" id="aplc:110981131"/>
    <dbReference type="OrthoDB" id="8735237at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.110">
        <property type="entry name" value="GDNF binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016017">
        <property type="entry name" value="GDNF/GAS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037193">
        <property type="entry name" value="GDNF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003438">
        <property type="entry name" value="GDNF_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269">
        <property type="entry name" value="GDNF RECEPTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10269:SF12">
        <property type="entry name" value="GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02351">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00907">
        <property type="entry name" value="GDNF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110035">
        <property type="entry name" value="GDNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665589" evidence="8">
        <location>
            <begin position="23"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="151"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="GDNF/GAS1" evidence="9">
        <location>
            <begin position="241"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022094099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022094100.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="69060" checksum="F8E8900A79D79BCD" modified="2022-01-19" version="1">MGAVAIAGLYIVLCALTPRGLTLDCKEAQVQCNEDHTCAVILMMVPDLCGNSASETTCDAPDRVQCEGILQILRQSQNFRGCSCDPDDAVSFQECEAVYSQLYKKQCSDSGQADEQEMPTETMQDTSAVSPWQYLDHVDNIQAEPSRESTCIEALNTCNFDITCRQSLYDYLTECRGDPATNSCRRTACRQSIRAFLDSVSPRYTHPLLYCYCDRHDAECDMVWRGLNAECAYKLTPLPSCLEVKEQCARSALCRTNFENYKFQCAISDTTGTGCAQSYSACRDARLGILGTIVAASCTCRSVEGTALEECKEQQRIVLDNSCFTRASQDYYPLVKNQDSAQTTTESLAIINKRVKSKEGCAVKLWNGYPDVHVPRGQNIRIANDDFAVCTQICRCIRTGYLSQCFDVLCNVTHPCNEGSRSPLNYQAVLSIAAVNLLHEGSQECICTGGEQVCIDKQRNFIDVDKPAMMIGYSVMEYEVIRRQLHVSITSQSFVSKLQSALSGVFMRNPCKLAAVNKYSVNGTDFNGTIVISAHSEHRQNWECLNQLSDLATMINTRAPPISSDVILSLIKIAGILEVAPETQQGQPQTFSYSRSAASLVPASHFLYLCLPFFFPFLTTMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQS4</accession>
    <name>A0A8B7YQS4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metabotropic glutamate receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110981507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094810.1">
        <property type="nucleotide sequence ID" value="XM_022239118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQS4"/>
    <dbReference type="GeneID" id="110981507"/>
    <dbReference type="KEGG" id="aplc:110981507"/>
    <dbReference type="OMA" id="KIACCWD"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000145">
        <property type="entry name" value="Glutamate receptor, metabotropic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000008">
        <property type="entry name" value="Metabotropic GLutamate receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034191021" evidence="11">
        <location>
            <begin position="20"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="788"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="568"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022094810.1"/>
        </source>
    </evidence>
    <sequence length="915" mass="101972" checksum="37C23B51EEA447C2" modified="2022-01-19" version="1">MNTGFCVVLAFSIFLVVHTDSISPKVYEEPGDYIIGGLLPVLEENCLFLRELETLHRLEAMAYAVRQINNRSDILPNITLGFRIYDTCSREPTTVAHTTLFIPDASINLGATASCEDPFKEWKPVIGVVGTEKSSTAKAAAQLLGVYKIPLLSFFATAQELDDKIRYPYFLRMIPSDKLQVKAVVALMEEFGWNYVSVIYSSDSYGRDALASFQEELTFKYTMCIGVQFEIDTNTPSVVVDIAVREILARADTAKVVILFTQANHANKVLESMTRMNAKGKIQIIGSDGWGMSMGEIKKGNREMARGAIKTQLPDEEDLDFEDYFIDLMIANDSTLPGYKNPWLDQYKVKYALDCVVGHGCDKVYGRGFSEPSGVSRVIDAVRVYAYALDEMVWDYCNATTNSSPPCNISNLVVEGETFFQHMTAVIQPGSRYSSMFAHSSGRVMQKRYELEVIQEHNETQYELKRIGIWDLLHKLTITEPNIPWGVPGDQGEFSSPPSYCSKPCEPGYIKTGIGERQCCWECTPCGQRDIVVNETVCSPCQDREVPDQSRLSCEPVEPLYIHWEDPVAIVLVVITSLGVVATSLAFLVYVRNNRHPLIKASSRELSYLMLLGVLLCYGMVFAFFGRPSVATCYVIRAGFMLGFTFTYAPLLTRANRIYRIFKAGKRSTKRPSFISPWSQVVMSLVLILIQLVISTAWHIKEPPAPVEKVPQPGQVELMCNISNDEMIISLSYNVILVVLCSVHAFITRKVPNNYNESRFISLSVYTTLVIWLAFIPCYFLIPGAVVQLVVMAVALIISGSITLAFMFFPKLYAVHFVAEDHVHAAATYREPGSLTNSKAAGEGSSSDKLAALRRDLTSTARTLIRSSSVAPTTMNVASQIDLRGDLALTDNVIQQRNFQSLTPTQALDPNDMIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQU5</accession>
    <name>A0A8B7YQU5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8 9 10 11 12 13 14 15 16 17 18 19 20 21" type="primary">LOC110981628</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022095040.1">
        <property type="nucleotide sequence ID" value="XM_022239348.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095047.1">
        <property type="nucleotide sequence ID" value="XM_022239355.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095056.1">
        <property type="nucleotide sequence ID" value="XM_022239364.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095066.1">
        <property type="nucleotide sequence ID" value="XM_022239374.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095075.1">
        <property type="nucleotide sequence ID" value="XM_022239383.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095083.1">
        <property type="nucleotide sequence ID" value="XM_022239391.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095092.1">
        <property type="nucleotide sequence ID" value="XM_022239400.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095097.1">
        <property type="nucleotide sequence ID" value="XM_022239405.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095106.1">
        <property type="nucleotide sequence ID" value="XM_022239414.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095117.1">
        <property type="nucleotide sequence ID" value="XM_022239425.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095127.1">
        <property type="nucleotide sequence ID" value="XM_022239435.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095134.1">
        <property type="nucleotide sequence ID" value="XM_022239442.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095144.1">
        <property type="nucleotide sequence ID" value="XM_022239452.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095153.1">
        <property type="nucleotide sequence ID" value="XM_022239461.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095161.1">
        <property type="nucleotide sequence ID" value="XM_022239469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQU5"/>
    <dbReference type="GeneID" id="110981628"/>
    <dbReference type="KEGG" id="aplc:110981628"/>
    <dbReference type="OMA" id="MAYKWDE"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000002">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF29">
        <property type="entry name" value="AMINOACYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022095040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022095056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022095066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022095075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022095083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022095092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022095097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022095106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022095117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022095127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022095134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022095144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022095153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022095161.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="23936" checksum="6F7D6A632097E91A" modified="2022-01-19" version="1">MEADLLGKRPEPEGGLTVNQDYLRALSEMGIPEPMAEKALLMTGGHSVEAAATWYFDCPDDLMDEPKVADQEELLRLAGEVETNWTGKKLPTCTHMVGGLSGQLKMIFVVNEELKMGKGKIAAQVAHACLGLYRTLQQHEASYGQHMVQWEKQGETSIVLSGSNTEHLLDLQRRASFASLPTHLTQDVGKTEVPSGACTVLSIFGDAKLLDQITGTLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YR33</accession>
    <name>A0A8B7YR33_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Monocarboxylate transporter 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110981033</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022093876.1">
        <property type="nucleotide sequence ID" value="XM_022238184.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093877.1">
        <property type="nucleotide sequence ID" value="XM_022238185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YR33"/>
    <dbReference type="GeneID" id="110981033"/>
    <dbReference type="KEGG" id="aplc:110981033"/>
    <dbReference type="OMA" id="CSHWATD"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="22"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022093877.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="51961" checksum="6F158AD71F29316F" modified="2022-01-19" version="1">MNSKATTSDCGRGRRLEGCRRSIVVVAAAHLATALVTMPVSCASVLYLSWKNEFDSSAKDTAVVMSLVICMTLCCCLLGGVLTKRYGCRFSGMLGGALCSLGFLCSHWATDLVHLYITAAIIGTGAGLVYCSSMVTVAQRFKKHYKAANSVAYAGFGTGTMAGPPVVQLLLDSFGWRGAMLVTSAFAANMVPLCAFFRPPDPLDRSRLEPGPRGDELHHLRGAEEDVPSLGEDGVFDAGKECSVSQTAQDGNNDRETTGCSYFPHVMREGRITRMCQGAVTGLGLDTLLKSYRFTLLCILIFGFHMPYTAFVQFAIPRAEGIEVAPSSASFLLSIAGIGSLLGRLGNGLMLNSRVPAECVAGLCIATAGASIFLMNVDSYASLAVASFTQGFTSGALFAIVNVLVRRYVGLRSFPICIGLYNFFAGGIGSLLGPILAGWLFDVTSCYKTVFFVMGGLYLASAPLFLLFPLLKRVEPGMGTATSELDLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRI6</accession>
    <name>A0A8B7YRI6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein capicua homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095893.1">
        <property type="nucleotide sequence ID" value="XM_022240201.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982059"/>
    <dbReference type="KEGG" id="aplc:110982059"/>
    <dbReference type="OrthoDB" id="10051111at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21990">
        <property type="entry name" value="HMG-box_CIC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000010">
        <property type="entry name" value="Capicua transcriptional repressor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052412">
        <property type="entry name" value="CC-Dev_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032147">
        <property type="entry name" value="Cic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058607">
        <property type="entry name" value="HMG-box_Cic-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058606">
        <property type="entry name" value="HTH_Cic_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059">
        <property type="entry name" value="HMG-BOX TRANSCRIPTION FACTOR BBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13059:SF13">
        <property type="entry name" value="PROTEIN CAPICUA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16090">
        <property type="entry name" value="DUF4819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25981">
        <property type="entry name" value="HTH_Cic_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="7">
        <location>
            <begin position="991"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="407"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSN8</accession>
    <name>A0A8B7YSN8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin phosphatase Rho-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981831</name>
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    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095480.1">
        <property type="nucleotide sequence ID" value="XM_022239788.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110981831"/>
    <dbReference type="KEGG" id="aplc:110981831"/>
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    <dbReference type="OrthoDB" id="9942268at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052223">
        <property type="entry name" value="Actin_Cytoskeleton_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271:SF1">
        <property type="entry name" value="PROTEIN OUTSPREAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
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    <dbReference type="SMART" id="SM00233">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="55"/>
            <end position="161"/>
        </location>
    </feature>
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            <begin position="164"/>
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            <begin position="201"/>
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    </feature>
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            <dbReference type="PROSITE" id="PS50003"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="RefSeq" id="XP_022095480.1"/>
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    </evidence>
    <sequence length="402" mass="44661" checksum="79DBF2E7BF8971FB" modified="2022-01-19" version="1">MMGFPRRGEDNLTRATSMCKNFQPNMFNKTKCQNCFRTREAHDLDGGDGSNKPKKVLLCGYLFIAPGLDPENPISRTRKWQRRCFILYENGELAYALDDGINTVPQGVINMYQCSTIFNADTQTGQKFSLGIQTTTATTFIRAETREEKDSWLETLSEYPEINKENERLKQRQQKLAAQHAAREEKYAKLNAKPDTPPTGSPKTETPPKSTIDQSWPKASEESVLKELDQSKCNDPLKRSQSSVESRPRYSDPTNSSSLYSRTISVQAPSALDQPDHSSQLLTSKRKNEIPSSLSAKSIRSDEDVRSASQARTPQDTETPADLQGTRMSSRLRSRIRASDTGISELSKMGAAQALGIQRSRSDVVINRSAYTPSPPEQQQCQLGCAWAGEPRGPAAAELAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSU2</accession>
    <name>A0A8B7YSU2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sodium channel modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110982341</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096363.1">
        <property type="nucleotide sequence ID" value="XM_022240671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSU2"/>
    <dbReference type="GeneID" id="110982341"/>
    <dbReference type="KEGG" id="aplc:110982341"/>
    <dbReference type="OrthoDB" id="1924550at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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</entry>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    </evidence>
    <sequence length="1263" mass="135997" checksum="81EA5C0F90844BDB" modified="2022-01-19" version="1">MISIVSVHNTEYWGDQDSLSDHSGDMDAEPDSDQEQDLDKMLGTWLGELEIMTKNLDSNAPATPTSPPLPPPITPSTNGLDNFQFSLLNLEAAKDSFDTSLQDSPDVDLDALLGDLCQMEQSLNAQMQDCDSKGDTTPQFPSYNVTDSTGAASVTRAPPVIHTVPATPPVTGNTPLGLAVTPGEEDVAMPPPPPQATSDAVDSEMPLPPPPPPPPPPADIPDNQMPSPPPEPPQAAPPLPPKSQTADTAPIPNSTFVCAIPPPPSVVTAPPSSQKTAPASLSIEMGGGTPAKSATPSSLTPMSPISPGQTPYSMSVRVKLQDIEAQLASDTSLTEEEKAAKLKAEKIKIALEKLKKARVQKLIIRVYSEDGSSKTLFADETMTCRQIVHTLVDKNHLEEKADWALVEQIPELYMERVLEDHEHLVTDVLLHWKRDTTSRLLFSERREKYAVFRNPQNFLLSSHTSQVATEFAEKSKQSLIDEFFSEGRQGVPEIEGPLFLKAEGKKSWKKYFFVLRASGLYYTPKGKSKSSKDLVCLVQFEHVNVYNGVGWRKKYKAPSDHCFALKHPQLQQKSKYTKYLSAEDYRTCQRWMAGIRIAKYGRVMLSNYTETQREMVDYSSSVESMSTSSLGDSSSISSMHSSASSHSTQSSLAGVSPSGSTLSVPPVQVNTLPTRQSSMGNMFASAWKKGKEKESKVDSPNLDRYCGRSPGPGERIPDEGTFQFKAPLVSQSHPTTQRQTPNDNDDVERTLMELEMNLAHDQEPTQLDRQQSQVHARPAFYKLPAPLGPKPNLNNSNAGPVHVHVTARNAEAVTVKVSPMSPSFSTSSSPSSSPSSWTSSPSSFSGCEARSNPPPVAPKPTFSSSPSSSCLSSSTNKTSPGSDSSCAKQTSSIISSRPRDTNLGRSESKRVQFKEVLEEKIPVRGRAAEKEPIASPPSSPLKPILNTSPQNPTLPSQSFSKTSFASQSQAPVSSTFQSPTASHPQQPPRSCSFTPSSYSPPLPHTTLPHTTFSPPNTSNINTIHQLASGGLYSTARQPRALPTTPSTQSNGYGHPQQPPAQQGPPRQANSSFLAELNSALVKPKPGGPAGKPPVSPRPPLSPRPKPLKQETATQQNITRPGGPSSPKMHSVSPISPRDSMTTFSNPPKTQLACKQGSPVPSRAQYPPTSPGTPPKSNHRPREGPASPRVRDSPPSSPASPGGIFVLPPSPTAQLKRAFTAGSQVKRSGSNKGAKPPPPPRRDGTTQLTTGDRKQPPSPPQRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWP9</accession>
    <name>A0A8B7YWP9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Complement C1q tumor necrosis factor-related protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110982649</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096914.1">
        <property type="nucleotide sequence ID" value="XM_022241222.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096915.1">
        <property type="nucleotide sequence ID" value="XM_022241223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWP9"/>
    <dbReference type="GeneID" id="110982649"/>
    <dbReference type="KEGG" id="aplc:110982649"/>
    <dbReference type="OMA" id="TTFSGYM"/>
    <dbReference type="OrthoDB" id="10062814at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665634" evidence="6">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="142"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022096914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022096915.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="29312" checksum="8488D80A576DB325" modified="2022-01-19" version="1">MEIIRIVVLLGVVHGVVSARGATRSSISKVINPAEGPTSSPEGHCGSCCIQGPPGPPGPPGTPGAAGMPGIPGNHGMNGIPGNPGPKGDAGQRGEMGPQGSPGSSLAGFAGLQGRSGERGSPAELEANLLRPLSSEASAVPHPPTRSAFSAARMTTIVAPKNRDLNIPFEHVFSNIGNHLDPTTGIFTAPKRGAYMFLINIHMASTTNNPYVKLMHNNQMLLSVHDYDSSDAYDSASNSLIVELQERDQVWLQLDQGNEVHSNTNRYTTFSGYMLFELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWW0</accession>
    <name>A0A8B7YWW0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette sub-family A member 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022097182.1">
        <property type="nucleotide sequence ID" value="XM_022241490.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982808"/>
    <dbReference type="KEGG" id="aplc:110982808"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000327">
        <property type="entry name" value="ATP-binding cassette sub-family A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000264">
        <property type="entry name" value="ATP-binding cassette, sub-family A (ABC1), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF185">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="787"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="865"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="892"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="922"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1693"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1995"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2035"/>
            <end position="2058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2065"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2104"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2197"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1055"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="2256"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1487"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1535"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2639"/>
            <end position="2716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1554"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1582"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2668"/>
            <end position="2677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2681"/>
            <end position="2693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097182.1"/>
        </source>
    </evidence>
    <sequence length="2747" mass="306829" checksum="D9E4652764BE3E5D" modified="2022-01-19" version="1">MAFFSQLQLLCWKNFTLRRRRKLRLSIEIVWPILMFMIIALVRKDELPNPKHECHFLSKALPSGGLLPFFQSFLCDFDSKCHREETYGETMGHINNYRDAGLTKLVEDIEVVLSNKTTMESLKKFLTKVAELNKLLPFMDNLNDVADTIPGSRSLIDYLNDPDEVKRFLTNDLHLSPEVTQAILNSNVSAQELVALMNADTFQSASCDEDRLRQLFDVTNETTLHEMRQELCNLTSADFASVTQVLAKQLDLNKLLPLISGGDTFPSGLFGLDGLKAFGDALQQTSGLPLSYNLLTNETELIVYLETQLGLSEADAKLVAGSINNPQLLLLLLTGHNMRNTVCNTTLLENYVTTTDPAQLEDLSETLCNLTDTDLDKLSQEIQKLIDFPALWNSLNGTDLEDWYKEILQEMIDIGREVAELDSFKELLSDIDSIMNNNDTNQLICGSVGGIKNFTDLGRTGGSFNGFDKLSSSPGLSRTTSSRSPEKDKDKNDTLALREDCEWVQQIESSKIGQLAWKTMKPMIQGYILYTPDTMATKRIMKEATQPLTSLALFKTLAAKWLDYSPTLRKYVEDSAAFELANEFSQNPELVKQLEDRLHSNGTADVVLLQKVLEDARNKSMESSNFTQSLLDAIDALDKFANTTMEILKCVNLNKTIGFSTEEEFLASAKELQGEDLFWGAAVFEGFNSSADNDTIPNYVSYQLRMDSRMVRATDKYKKYFWKPGPMSSIYRYGEYIRGGFIFLQDMFDQGIIKASLRTKDAGAGAYVQEFPYPCYISDLFVQTLGAILPLLMIIAWLFSVAMIIKGIVLEKELRLKEVMKVMGMGNAVHWVAWFINSFVVMFISSCLLVLILKVGKITIQADASVVLLMLVSFSVSTIALCFLVSTFFSKANLSAACGAVFFFLSYVPYSMVYSWDEYIPGWAKLFMCLSNTIAFGYGSQYIALFEIQGSGLTWGNLGVSPASAGEQLTPQQVITMMWFDAFLYMVLTWYIEAVFPGAYGMPRRWYFPFQRSYWCGSDTVETQDADLLQTTSSNGIPTEDTDFEREPTHLKLGVSIKNLYKIYRIGKKLAVNDLSFNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTAGTAFIYGKDILTDITRIRKSLGMCPQHNVLFDYLTVEEHLWFYARVKGATNDEIAVEMEEMLKHLNLPHKRKELTANLSGGMKRKLSIAMAFVAGSKTVILDEPTAGVDPYARREIWDLLSKYKEGRTIIMSTHHMDEADVLGDRIAIISSGQLRCSGSSLFLKSRFGVGYYLVLNKRLPGDDLMVPPQMTDPMLYNAGLQNGGFGPMVGPDLVAGAMTNLPSDEKKEMDLDLVEPSQMKVALESTDDDLRHKKDKPPIDIPDCGSCKESVVTSFVQSYVPGAVLCENLGKELSYILPAGATHYNALESLFQELEIYKERLFISDFGISDTSLEEVFLSVTDDTGIFYEAETFQSSDNGLLPRPFMGRGSLRRRSYELPARSNSIREQRSRKRSTADNVALVDVDELDDAHQELEEDIHSLHSINLDADGTDGNEPASNKEDNQVSQEPSQNRGQNPDQNPGHQPVQQSLHPRVKRQLSRQLSRRLMRQASREAAMNQQANDVDVVESPSLYTRVQSLLHPRFRAVPTEVSISDVRTPDAESCRVHAADLSGHEVHGINLIRRQFYALLVKRFHHFRRSKKGFFAQVILPVVFVCVAMLFTVLMPPKTDTKKLPLLPWLTGTPNYVFYSNDNPGDKLSTGMEASITLDEPGIGTRCMAEDPFTEDGFPCQPKSSTDWSTEQMDPDLYEKYLNGELTCECSGKSFQTCDKGAEGPPPPERTVPTTDILQNYTGMNISWFLTTTTLDYIWKRFGGVSFLDTDELAPLTPNISKDLLADWSKTDGSSDINLPGPINDLVPSDITMEDIYAVMLSLARFKNVKVWWDNNGYHALPAFINVANNMLFRGNMDESERHKYGITTYNYPINLTSDELQDIIMKELPISMSTAIFVVFALAFVPASFVVFLVTERESKSKHLQFVSGISPTTYWVSTLLWDLMNFLIPVVLTILVFRCFSQKAYIGTEALPATILLLLMYGWAITPMSYPASFYFSTPSTAYLSMACANMLIGIVTIMTTFILEFLGMDDSNLMSTNESLKKLFLIFPPFCLGQGLMQMSNVSLQSEVESKFQNLLESDPAPTNVLAWDLVGKNIFALGMTGAAFFALTLLIEHKFFLKSRLIKAEQTPLAYEDDDVVRERHRVLSGGAQNDVVRVENLTKDFNTSRGICRAVDRMCVGIPRGECFGLLGVNGAGKTTTFRMLTGDTQVTSGCAYINGLSILQDMKRISHSVGYCPQFDALNELLTGEEHLAFYARLRGVPEEDIKRVVEWGIKKLGLTKYAKRVAGTYSGGNKRKLSTAIALIGDPQLVFLDEPTTGMDPKARRFLWNRITGIIKEGRSVILTSHSMEECEALCTRVAIMVNGRFKCIGSTQHLKSKFGDGYTISIRVGGDPPRLEPLMRFVAEMFPHTTLRERHFNMLEYQMPTASTSLAKVFGVFGANKERFLIEDYSVCQTTLDQVFINFAKEQKTGDEELQETDPLGVTVVNTPDSNQILMSPAFGSVQYVPENSSVYGGGVPHDDLSGFSNPMYDQVHGVPLPASTRPNGKGFTNPLYESSRDGAPAPGLNSNNSNAANRTGDIGHDEDGEKSVEDTPDECLIPGQTPEHDLGQTPQQVSSLELLLRAQADEKLLSFCPDEGTADDPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXH7</accession>
    <name>A0A8B7YXH7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase DDB_G0268948</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110982107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095976.1">
        <property type="nucleotide sequence ID" value="XM_022240284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXH7"/>
    <dbReference type="GeneID" id="110982107"/>
    <dbReference type="KEGG" id="aplc:110982107"/>
    <dbReference type="OMA" id="PNNISYR"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022095976.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27694" checksum="1F5AF6D9ABFE669D" modified="2022-01-19" version="1">MAYAKSEPFKLAVDVGCGSGQNTRPLAPYFEKIIGVDVSEAQIRAAQSLENPPNVEFRIGSAESVAVPDRSVDLITCAESVHWFDLDAFFREMDRVLKPNGCIAIYTYHKIRPWVEGDDVKNEQLKDVVTQVSIAIRPYSSPRSQHLHNKLADIHIPYDETTRDESFDIRYDTTVASYMDYIRSWSNYQVYLEKNPSGPDILKEVQERLMEILSLDCPAEDAKIHVRSSVVLLLGRKPREETGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXV4</accession>
    <name>A0A8B7YXV4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110982989 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097512.1">
        <property type="nucleotide sequence ID" value="XM_022241820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXV4"/>
    <dbReference type="GeneID" id="110982989"/>
    <dbReference type="KEGG" id="aplc:110982989"/>
    <dbReference type="OrthoDB" id="10347843at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022097512.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19500" checksum="27831B471B3CB5E2" modified="2022-01-19" version="1">MQYSTKKCILTYSGAIMFAFGFGIMLDGIFYRTTGATSGAVLNSAGNAVVKSVPHWCGLLLILLGARNFTFGIAQWKYGVNCCGGGACEVLFVNLMALIVSLAAVGLAILGSWDVLNNASASSIGSVPDFTYLISIWFMSLMCAILALMSMCAGCLPVGEPQEEEEIEMQQYGHDNPQFSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYF2</accession>
    <name>A0A8B7YYF2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein with metallophosphoesterase domain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097515.1">
        <property type="nucleotide sequence ID" value="XM_022241823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYF2"/>
    <dbReference type="GeneID" id="110982991"/>
    <dbReference type="KEGG" id="aplc:110982991"/>
    <dbReference type="OMA" id="DWFYLAG"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07385">
        <property type="entry name" value="MPP_YkuE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051158">
        <property type="entry name" value="Metallophosphoesterase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31302">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN WITH METALLOPHOSPHOESTERASE DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="262"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022097515.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="55709" checksum="A2F9602B3E84CEB3" modified="2022-01-19" version="1">MVTKFSLKQMERPQWIKIVVLPSACALRPSVYFFTNTTNTDVRVTGYRCFAKRKMAAPRLFKTFLLAASFLVSMCVFFIAYLTSSSMGFGTLSIKRAGILLGIFVPVIFLISYFVVWRNLVLRPMKSMEKSCVQGVVFHTWTAALFVFLLFAHFSQLCILFLGKTTEVGTVSFVSFICFGALFVLAAVIFMFEIVEFFLKMTFQRGLSWEWFQENWLVIRAVMIVVISSCLVAVSVMNAAEGPVVKPVEIPVRKLPLSMHGLRIVQLSDIHLGPTVGKSQLQKSVNVANALKPDITVITGDLVDSTVENLVEAVSPLQQLRATHGVYYVTGNHEYYTYDVKHWLSHLKSLDIVCLSNSFVRIVHAQKPRDWFYLAGTNDIEGKRMYEKEHQFDLDKALASTDSDHAIILLAHQPKAAKQAVQSQYDISLILSGHTHGGQMFPITIPAYLFSPYFAGIYQPKEGTYVYVSSGTWYNGPPMRLFSRAEITLITLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z080</accession>
    <name>A0A8B7Z080_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110982603</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022096841.1">
        <property type="nucleotide sequence ID" value="XM_022241149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z080"/>
    <dbReference type="GeneID" id="110982603"/>
    <dbReference type="KEGG" id="aplc:110982603"/>
    <dbReference type="OMA" id="ICRICHT"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046356">
        <property type="entry name" value="MARCHF4/9/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46053">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46053:SF2">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="15">
        <location>
            <begin position="205"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022096841.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="47448" checksum="AA25A12B693FB752" modified="2022-01-19" version="1">METSSHTPLLTEMRSNASAPALGVALVKVQLDAGMSEHPLTQRAVNSVSELPPACPLGKRKSTGASLVKISCNAGSKELVDIRDSARDEVIPCMCCEINNDDGQNLRSPLFAAAPTESGRFQNGAAASADAATGQSTDRPRLETSRSLPSILLVPERTRRDFCQTPASHEARCSPQSSSHRPVDPPSSVLRQSQRVTGIVSDSMLSLPTGDICRICHTGGRHESLIGPCLCAGSMRYTHQRCLTTWLAQSGRSRCELCGYKFKTKLVGSRNIFQWKVFPLTVTDKLHLIIFALSVILFTGTTAYITWTATKSDVMSSVDPASLATQILLPVYCSLSFVSLGLLVYETKSTCLRLVRRWRALNMGLQIVERDPGEENTRAGDGVDDDAAHQSGPSISGLISCVEGRAWGRVRAGSENQTVHTRGDGMPSGWSVWSEAPTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1V1</accession>
    <name>A0A8B7Z1V1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit tim16-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099584.1">
        <property type="nucleotide sequence ID" value="XM_022243892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1V1"/>
    <dbReference type="GeneID" id="110984079"/>
    <dbReference type="KEGG" id="aplc:110984079"/>
    <dbReference type="OMA" id="AKYLIQI"/>
    <dbReference type="OrthoDB" id="10262892at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022099584.1"/>
        </source>
    </evidence>
    <sequence length="135" mass="14635" checksum="25C968B676386958" modified="2022-01-19" version="1">MAAKYVAQIIVLGAQVVGRAFTRALRQEIQASQQAAKRAGGGKEGAQSAAKDSLTGITLQEAKMVLNVTKMDPELINKNFDHLFKVNDKSKGGSFYLQSKVIRAKERLDQELDGTERKDIGSGTTQENTKDAPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2J3</accession>
    <name>A0A8B7Z2J3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099838.1">
        <property type="nucleotide sequence ID" value="XM_022244146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2J3"/>
    <dbReference type="GeneID" id="110984207"/>
    <dbReference type="KEGG" id="aplc:110984207"/>
    <dbReference type="OMA" id="IRTFKFM"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022099838.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21643" checksum="CE86CD9385DB83E1" modified="2022-01-19" version="1">MKKRRRKKAEQCPNSAVNSQPMLPPCWSQANITYFSLAENHSGIPDVPTGSCQELLLEDATEESDTDGSFAPFFKTDDTGAGVSGTEGKKFLRFVHPLTDNRKLVWETALWKNRLYIQLPNDLAEQGSRDSLVALLDAAEEHLGCTQVIIGLPRDIMDRAQLIRTFKFMGFVLLPPGHPESPGSPDFLFMAYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2Z0</accession>
    <name>A0A8B7Z2Z0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DCC-interacting protein 13-alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983942</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022099337.1">
        <property type="nucleotide sequence ID" value="XM_022243645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2Z0"/>
    <dbReference type="GeneID" id="110983942"/>
    <dbReference type="KEGG" id="aplc:110983942"/>
    <dbReference type="OMA" id="FKMTELH"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047181">
        <property type="entry name" value="DP13A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415">
        <property type="entry name" value="ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46415:SF2">
        <property type="entry name" value="BETA, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="282"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="10">
        <location>
            <begin position="555"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="692"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="732"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="758"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="787"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022099337.1"/>
        </source>
    </evidence>
    <sequence length="849" mass="94392" checksum="A94DEDBE9E7727CD" modified="2022-01-19" version="1">MPGIDFLRLEDAREDSPQAKSMLGLFEEDTALFTNYVSGLLAACRKVVDCENELSIAIQALSQKLQDYEKLHFPLGRDDSILASTLKQFSRTMEEVSSVHTAHSTQLNDLMVQPLSSFTNSDLTEITNMKELNRMLEQEHENAIVKYCRVSKKKENETKARIDANDELYSCRKKLLQNSLNYYNSLNLLQYKRTSNLLQPMLGFFQAQLMLFRLGKETLTKQTEDYLANITESLQSVHSELGQLSQRSSDKILEITENSTYYYMPEPTPDMQMQPRPVNTGFSQIAGYLMIRSKSGLTHRWERQYFFTQGGNLMSHAKGQIAGSLVIDLDGCTVNAAEIDDRRFAFQITRPEDAKKLVSLQCMSGSDREEWIATIRNISSGFYMPEKPPQSNIPQTQAVGDARSRAFSAPPTAWAVPVPSTQGGSGGEGTITTPTGGTRPKQPMSLSNVPQKQRADSYKHSGKEKSLSSDISRSSSQDIPATPPPSPLDSVLSTTPIQFDMITPSEEQPPAMPRYAPPTKEGSQRRVNPFDDKPLESRPIQVLGATDPVGYIQTYLLRFLGSMEVRRDKGLDIIMDTIRKIMAARAIHNIFKMTELHLIVTSQSIRLLDSSKQVVKAHHDLTDVSFWAAHQENKRLFAFITRRHGARHQPQFICHVFEADVAAEEICQAISLAADIAFQALLQQRTTALAQGQTQDKGDSSNLVLEAPSNPPVNRYNQPPFHSRHQGQILSPQPDQQVLQPGQTQLQLDQTQLQPSQAHSLPQLQQNQPPTHPSQPAGFIPVYTMPSVDQHSNQQPTGPAYNSNGNNSTYGGSACSLQGPIASGLEGLNLGHGLRGRVDSLKLADESDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4K6</accession>
    <name>A0A8B7Z4K6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Homeobox protein Nkx-2.5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110983373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098281.1">
        <property type="nucleotide sequence ID" value="XM_022242589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4K6"/>
    <dbReference type="GeneID" id="110983373"/>
    <dbReference type="KEGG" id="aplc:110983373"/>
    <dbReference type="OMA" id="SHQTISC"/>
    <dbReference type="OrthoDB" id="3137333at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000078">
        <property type="entry name" value="NK2 homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF111">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="198"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="200"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022098281.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="41265" checksum="B4DF5EE07D377238" modified="2022-01-19" version="1">MLTRKCGAFTLPETMQETGTMSGYHGYPQSMGYHSSTTPTTSPAASTTPFSVKDILCLAAAQQHQHHHHHHSRHQPVPQAPAMQGYQDHSLFPMTDEAFLVDTAAFPCDMSAASCAVSSPDEARSSCSYPSAMGFAEVAPSSTSPLDQKLPILQSHQTISCQEICRSVDTKRPTNHHHHPQLGGGGAVGGDKQPSKTRQRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLATLLKLTPNQVKIWFQNRRYKSKRQRQDKSLELAAGGHHPHHQQFPPRRVAVPVLVRDGKPCLGSLGAAASTPHSAPPPPPPPPPPPPYGYTACGGYSSAGAGSSVSSTGRFVNSCSYTGGLPTGGASSHGNGVGVYSQPTIQQAVRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4P3</accession>
    <name>A0A8B7Z4P3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 46 member 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984581</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022100604.1">
        <property type="nucleotide sequence ID" value="XM_022244912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4P3"/>
    <dbReference type="GeneID" id="110984581"/>
    <dbReference type="KEGG" id="aplc:110984581"/>
    <dbReference type="OMA" id="WFIFACF"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022100604.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25262" checksum="124BBEE36293C493" modified="2022-01-19" version="1">MASHLLALCMHTLAIFRNPSTGEWNGVLIVEAITFFAYTHLGVFFLAMLQIVMLGEPFCWSPILIGYFSAAKLTGIIIGMTVVAKILQTWFDDYGLIQIGLLSMFTSALIPVYARTDAGLFLVAVFGAFRLVPGPILTSSLSKLVKKSSMGSVFGLTSAVECLGAFLAPTIYGTIYQATVEDDPMFVFKLMAGLTAIPSALVLFLQCWKCTSGAANYNEVKEEKLLPTSTSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8E8</accession>
    <name>A0A8B7Z8E8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sushi domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110984057</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099546.1">
        <property type="nucleotide sequence ID" value="XM_022243854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8E8"/>
    <dbReference type="GeneID" id="110984057"/>
    <dbReference type="KEGG" id="aplc:110984057"/>
    <dbReference type="OMA" id="EVCRYDY"/>
    <dbReference type="OrthoDB" id="6236007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF59">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034481446" evidence="9">
        <location>
            <begin position="28"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="12">
        <location>
            <begin position="107"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="10">
        <location>
            <begin position="507"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="13">
        <location>
            <begin position="672"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="950"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022099546.1"/>
        </source>
    </evidence>
    <sequence length="1250" mass="137846" checksum="B59BBDC3C58C84EB" modified="2022-01-19" version="1">MRTVGSKSAIPGLCLMVWLLMARVGDATSQEQDLFFPYGPDEGDVELPIEDDTGIELQISISYFPFFDQNHRSLYVNTNGVVSFLENVVQYTPDSFPLGNNRRIIAPYWADVDVTNGGHVWYRQTEDPTLLRRATDEVARVFAVDFRFNPFKAEWLLIVTWDRVAFYNSRAGIHGNRENTFQAILITDSVYSFTIFNYGELQWTTGSASFGDKQTGLAGDNERAVPAQVGFNAGDGLNFYSVPNSQTDEILKINTTTNIRKPGRWMFRIDGKEIEAAGCENDLDGNLRISPAQVIMLGGDVLSISGPCFDVSNDVFCRIQGYEIQASYDFTKDPFTVRCATPLFMALGESPVYLSKDGGQTYNYTGYITVVGMDRIPPRVVPTQDNDVLRVNWETDGYPFTNSLNEDDVRVDVFLYSYTEDPTTSEVRLKPVLKIADNRKLSNGFDSLIKPQLGEPVDVGIYRVVEHGAVDISQPGISVVMGLPSKDPSQAPIPSMWSMPFNANPENQADSDSWCRAWAGTETPLDLTGDNLPPCPCTLRQARADVGTFEPYPWCNQGGTGNDNCPYRTTVVHCVRARRGSALGRGQLCCYDDTDNIVLLEDNYEGGSSQSHFNGGHTPIGYPGNIPYLSNFLGDRVPWEQCCPRTGYNPSLCNIYTSRRPSDDCKNYLPPKPAAVFGEPHFITFDGSSYIFNGYGEFTLVSAPEVSLTMQGRMAKILDTVQATGLTVVAMKVGDSDTIQVEINDRRKLDVWVRREARAAWQRLGFEQSSWWTAKPRGATVELIGAEESQDVRVIFDQGTAFEAKAPAGASAMAIKILAAPSLKDGTTGLLGKWNDDPSDDLKAPNGAIFSADSLTNLHEFFGVKWFISQNDSLFRYDISVNVSNINQPDFQAVYTLDSTLTEEQLNTVCRDSEVCRYDYQKTSSSEMGTGAKDAEEGYEGTRGDTTPVVSCGFLEAPQGGRKSGTVYLEGFTVKFSCIEGYEMMGSASRQCVQGVWQGNVTVCTPPAASMRDLIIIIIVAAVLGGILLLAICFLCIICCFRRKRKMARKEDHELGTISTVEGFQNGALVTTPLADDRTPSSNSSIIEDPNYEHSLPRRNHHDTAFPFPDVNPGYMDMAPSRPPRDRQMATPVDGPGYRGSTIASGGPGYRSAEEAVAGPSHAGSSQASARHIPGGPSLSKKPKTRAQENPYEDPLQARGKKGKAKDMNGSIIKDPNTLQYNSDESEDDIAIIKRRIREEVEQEEQEDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8M8</accession>
    <name>A0A8B7Z8M8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mediator of RNA polymerase II transcription subunit 12-like protein isoform X3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110985351</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102014.1">
        <property type="nucleotide sequence ID" value="XM_022246322.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985351"/>
    <dbReference type="OMA" id="YQQSHDK"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021990">
        <property type="entry name" value="Mediator_Med12_LCEWAV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12145">
        <property type="entry name" value="Med12-LCEWAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12 LCEWAV-domain" evidence="9">
        <location>
            <begin position="141"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="503"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="593"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="673"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1267"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1601"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1904"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1956"/>
            <end position="2021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="673"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1636"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1648"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1658"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1669"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1956"/>
            <end position="1980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1981"/>
            <end position="1997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022102014.1"/>
        </source>
    </evidence>
    <sequence length="2021" mass="225751" checksum="AEE8794BE8B5B87F" modified="2022-01-19" version="1">MTRATWFLKMTAAHSAAMSETKIKKRAPNDPSLDWCQMLTKFLRDQLTKIVEYHHTLAATQSATMSGLGSLAAPSSLPLEIEHAFNLWQYNCRLARYLYQEGMLECHEFLSWLVEITEKVKQHDDNTFRIVLPFNLQFLEEFVRSQMLSRRLAYMCVRRLTAIINDATCATNPPTPSPHMVTSPTSVSMPSSQPTPQPALAAIFAEYTSCPQHRPIVVGLSLILQTVALRCPSALVWINIGEGKSLSAPGSPLDILPCAPSSLPLPGPPSIQNHHIRASIRNAEHQIKMRSRAAEVRWSSDKCQESTTDTKMAALCYQGDNPNITMYNCRGHTISRVLHVLELLDRHCFDRCDSTNCLDSLYNKIFNTPPNKDGSDMPLSDDPIILLLCEWAVCSERSGEHRALVVAQLLEKRVIDLESEKAEPDLLEEKESLSTVSLMPGAMPMLQGLLTHFLDTQAPVYVDENGPIEDRRAFASLVLLFSELIRCDVFSHDSYMCTLISRGDLTTSPLPSANSEPPPSSERMEVDPEKRTPSEIKEEPKDMDGIGIKQEQEEKEEYDDSDEDTKPSGIHKKESVSFQEKFLEALQSNKLSTEDSFFEDDKDERKKALREGGTPSPHPPPPKPNRHLMYATHFPLPQDEMSAHECNQRLVLLYGFGKARDEARHTARRIQRETLRALGSKKETTPGKSDSKAKHIKSEGQPVSFEHVLERYRTLSYFDQHAVTAACASHVLEQVQSCTQGSLDNLPSVEQITLVFELMENALNIHALLEFSVQLLNYMSIVEAELTQKSSPLAGNYTPNLCLSIVAVLRRYQACLLVSQEQTATVFELLCGIVKHVTNVTVCSSAERCILAYLYELYTSCSHVKAKFSDMFSSVASKVKQTLYTSVHPSESNPLWNPKFMQEYIQNPRDLQFHHTSLGKQLNESSTDRYSFVCNVLLYICSPTEVQMLNDLSIMCAELTSCCSALSSEWLGVLKALCCSSNPSCGFNDILCQVDVNDLSIHDSVAVFAAILIARHCFALEDVVEHVALTSLLDFTTPSLNAGTQMESDAEPGARLMCRLLLRLLSTGPLPGQSDKNGYYVKSSCDQHLLAAAHRSISVEALVGVLKAILLLGEAGVGGGTSGSFDDFTEDPRSSGSIETASLSDYAKFTLKTICSQSWVREIFLKDPDRLWTREVLLDQVLSHKHAHYLVQLICYPNGVPLISDGSYESEQKQAITRILRNLDQWTLRVSWLELQLMLKQCANSEMNPLLDNIAKATIEVFQQQHSDEGSAATKSAPGGQNGQRKAVQQIRLEQERSGVWLVAPLISKLSSQVQGRVLRAAGNVLESVGHTWSKSSKDKDKHGHKAQMSLVSHQPLLSLVLTCLKGQDEQREGLLTSLQTQLTQFLQSPKDDRWEDEQSRRMMHEALQLRLSLVGNMFDTILRSQQWTTEFALLLLQLITTGTVDTHSNSELFTTVLDMLSVLINSTLSSDCSEGEKGREHQTLIKKLKKELGDKHSYDIDRVRQLLPVPKKTCDVVTVEPMGSLIDTKGNKIAGFDSINKKQGLQVASKQKINPWDTLEAYKNPAPLSWSFFGAVRMERKPLKYQEQFRLTHYHTHHRERPDDYYFQPPQLPPDEEEPAPPPASGPEAEKAATDSSGNSLSESGKGEGSGSGSTAGAGDITSGVTTSKKRKRVRKKTPTPGQQMMREPFAYNQNMGGFPERPFMQQQQNYMPGQFPYQQPLPPAGPSRMDRQMPMGGNSKAALRNMLVDRKQPGNQREEVHYGSPILKYHLMQKQQQMAHYKQQQAARAMGGSGVSTDMFMQYKGPHEGPMHHMQPGQPQQAPSSVGYGGYGNQMMQQPQLTNDPMVSPNYSHYSAHGAQPTVGPGGMMGPQMGRPQVQPGQSGYMSQHRQVPEAVRLQHQLQQRASMQRGMAPGNIMPQHQPTAPHSGGQPYMQPLAAPQERQHQVLRQQRLAVLQKQQQQQQQQHQPPQHHQQDQQTANLVSRLKSQMTQSGPGSMGPAQAMQQQPPPQYNPYQQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBS8</accession>
    <name>A0A8B7ZBS8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD repeat-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110984621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100676.1">
        <property type="nucleotide sequence ID" value="XM_022244984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBS8"/>
    <dbReference type="GeneID" id="110984621"/>
    <dbReference type="KEGG" id="aplc:110984621"/>
    <dbReference type="CTD" id="10885"/>
    <dbReference type="OMA" id="MNIPLTC"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000172">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000177">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="406"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="584"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="626"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="668"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="8">
        <location>
            <begin position="804"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="715"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="735"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022100676.1"/>
        </source>
    </evidence>
    <sequence length="941" mass="105480" checksum="702B4684B6CEE71E" modified="2022-01-19" version="1">MGLTKQYLRYASSAMFGIVGTHKANVLFVELRGTQGKYAAAAACEHVFVWDLRRAEKMLVLHGDKSEVSVLAQSPQGQSLAVGYADGAVKLFSLITGEVTVTFSGHKSAVTALSFDERGLRLASGSKDTDVIVWDVVNESGLYRLKGHKGVVTQCRFMREHNILITSSKDTFVKFWDIDTQHCFKTLVGHRTEVWDFVLLGADQRLVTGAADSELRVWDITFQDEEETTDGSEQPAKKQKLSSIIGEDEEEEDEEETSILSCKGVGSIMRKGRQRVVSLSTDGTGRVLCCHGADCWLEVFLVLSAEEKNKLLSKRQRKARKKSRETAADGESQKEIPERLELKDEIQHRCVLKASSKIRSFATILENSAASLKLVLQLHSNSLETYIFPSMEGQQWEAEKQGMVTFPGHRSDVRTVAFSSDNTTVLTGAGESVKVWNRATQQCIRSMKSGYALCSAFVISERHSLIGTKTGHLELFDIAAGALLERVEAHEGAIWSIATSPDKRGFVTGSADKTLKFWDFELVKDPDSQQASKRLTVVHRRTLQMSDDVLCVKYSPDQRLIAAALLDSTVKVFFADTLKFFLSLYGHKLPVLTMDISSDSTLIVTGSADRNVKIWGLDFGDCHKSMFAHDDSIMSLQFVPHTHLFFSAGKDKKIKQWDADHFEHITTLEGHHAEVWCLAVSPNGNYLVSGSHDKSLRLWERTQEPLVLEEEREMEREQAAEEAMAHEEQPAFPGQSANSELASAGKQTAETVKAAERIMEALELYKEETAKEKEHEEIQKASKKEIPPFTKHPILQAYGNTSPTRYVLEVIKKVKSSELEESLLVIPFSYVLELLPLLETFISSGWQVELACRCLLFLLRVHHGQITSSQSLLPIIDRLRTTSLQQVHQMRDRIGFNLAGLQFLQQELESQKEVQLFGDATAKMKDKNKKRKRKLMITLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEP1</accession>
    <name>A0A8B7ZEP1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MAM and LDL-receptor class A domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104109.1">
        <property type="nucleotide sequence ID" value="XM_022248417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEP1"/>
    <dbReference type="GeneID" id="110986504"/>
    <dbReference type="KEGG" id="aplc:110986504"/>
    <dbReference type="OMA" id="CEWEDIS"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034795501" evidence="1">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="2">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022104109.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21607" checksum="B0EF81812B467A30" modified="2022-01-19" version="1">MACISLTCGLMLGLSLFVRASLGFDCTFEHGMCGWKQSWDDAGYWMRRSGRSPSYYTGPLSDRTPGSSTNYYCYSNGGSHSSSNAVLLSPIVKATDVRQFIWRFSFWYNMYGSDIGRLNVYKTPVNGRLSEGRVIFSRHGQQTSSSEWLEGEIYITDVASSFRIAFEAIRQYLYDDLGHIAIDDVTISDLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFP3</accession>
    <name>A0A8B7ZFP3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ral GTPase-activating protein subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">p170</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110986254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the heterodimeric RalGAP1 complex with RALGAPA1 and of the heterodimeric RalGAP2 complex with RALGAPA2. Heterodimerization is required for activity.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103685.1">
        <property type="nucleotide sequence ID" value="XM_022247993.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986254"/>
    <dbReference type="KEGG" id="aplc:110986254"/>
    <dbReference type="CTD" id="57148"/>
    <dbReference type="OMA" id="CWEECCV"/>
    <dbReference type="OrthoDB" id="10009983at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000005">
        <property type="entry name" value="Ral GTPase-activating protein, beta subunit (non-catalytic)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039930">
        <property type="entry name" value="RALGAPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046859">
        <property type="entry name" value="RGPA/RALGAPB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21344:SF1">
        <property type="entry name" value="RAL GTPASE-ACTIVATING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20412">
        <property type="entry name" value="RALGAPB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="8">
        <location>
            <begin position="1188"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="760"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1265"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1313"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103685.1"/>
        </source>
    </evidence>
    <sequence length="1542" mass="171210" checksum="087F4F7A85747CAF" modified="2022-01-19" version="1">MYSWWASMQAEIETDGSNRSVLQSFPDGVGREVVLSVVRQLANHLSSTATSSRVGSQHLRSPLDTEKEVLWTMEVICYGLTLPLTEQEAVKSCVNVYCEWLSALTIPKHSIPTPLLKDPNFFVQRILRHLINLFQPRVQPRMQGMNMHETTTQVMLCHRVLRSVQTVATESIVMTRQTWESLLKFLLAVNDTILAPPLEPGALSMVPVPDSLAEQLCERLLSVLFEIWLLACGRCFPSPTLWRTFTDMCATWRHHAATVEQWNRINKVLTSRLLKILYGPEFPTLPIADEEAHIIPTELDNDGVAQTWFRFLHLLGNPVNLCRPKVISHTPKFLAAAVSYQPSLEPHQFTCLQALPQIFLKAMRGVSVIIDAFLGILTPQSADPHSTRISTLPIDETPPLGRKISRKEQVSAKQIKEKVMSSHAPPLSSQASSVTMASFCVEDATDGRGTPTPRRSQCNSILHLFGAWLFEAALTGCKSRKIASPPRRRSLAVDARTNITNFAFGKAFKRHHSIAIPDASRSGHLSDLRAVSLQDPFPASVAANPLFDMSEFPDSYEAGRAEACGMLCRIFTSRKSDEEIQQAYLGRFYVAFSQGVRVDEALSGQVLSNVLYNSTNLLRIDLKGVQVLIPDIITALQIVLPEKEIRFQSLVSNQQLRRASIHLLLSMLCLPHHFKNLAIHDLMTGKEMTTEDMLGRTEQVTFLSLKPKLVDLMIAAVQCETDSYNTQMLLGAMHFCVLDSAMCEDMEAKQAKMEQTENILHEEDEEGMDAGTSDADKTKRDSDLDDKRASSGSRTSSRSSVAGRTDSAWVIFVRCCHLVCQRLMSAWSTDYTVALAALELLAGLAKVKIKILDSLECKRAVKWICDHIVYQCSRPSIPCSGVGLFLQECLQCVLEVVELGISGTKSQRKASVAPVFKHDKELKPASKRVKDAAEGLLACLLNHVGSFPNPCGPASVGSLLDEQSLLKYSANGASYGAHHQVSFRYFVLENATLMAVLERPVTDNGGEILPTVTTIIRGPTGRHVWTMKLRHWSKKEKGDTPSGLSYPMRPQPDDHVGTHHEITSRHYPEAVDKVPLTQADQSIPPLEDIETDTLRSDHQKLERLIEEQTEYERFVCESAMEDIKRGGYPNARTECKPPNPCREFSSARLILSHLGYLSLDSLKDPENSSIPPAVVALDDDLANFTSDLSALDAIPSRTYDTAFIFYVKAGQSEAQAIIQNVTDRANVQPQFLEFLGSLGWSVDVHKHAGWTGNVATSWKITFTDQTDSSADPTTEAGEEPSAEVHGGSLYNGETHVLYYADVMSEIAFVVPSERHHNSGRRHSAGDGIDEPPKTAPLLTHKSTKSLPLSTRSLTLDLPSDSGAPSTTPPQVSPMGSLERGRKSLHKKGLALGPEIKVLIVWLESFDDREAFPLTDLLEEMNTGLETLCQGGNSASQVKSLAEPTVVLMFIHPLKSGLFRIHMHGRPTQAIPLVDGMVVSRRSLGTLVRQTAINACHRKRMETDSYSPPHVKRRQKIQDMANKYRSRLSVPEFYTALFANRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFS8</accession>
    <name>A0A8B7ZFS8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Tripartite motif-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14" type="primary">LOC110986699</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104504.1">
        <property type="nucleotide sequence ID" value="XM_022248812.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104505.1">
        <property type="nucleotide sequence ID" value="XM_022248813.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104507.1">
        <property type="nucleotide sequence ID" value="XM_022248815.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104508.1">
        <property type="nucleotide sequence ID" value="XM_022248816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFS8"/>
    <dbReference type="GeneID" id="110986699"/>
    <dbReference type="KEGG" id="aplc:110986699"/>
    <dbReference type="OMA" id="YECSELL"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="379"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022104504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022104505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022104507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022104508.1"/>
        </source>
    </evidence>
    <sequence length="641" mass="71348" checksum="7F96EA5B21D621EB" modified="2022-01-19" version="1">MAESTTKTVLGEISQGHLECPICFCRFKEPKILDCLHSFCLNCLDGMLSAKQPDTSKISCPVCRKETPVPVVGLHGLLDCFFLSSLVDEFNQREQSLETLQSAIAPTCGDCEEGLEAMSRCLDCETNLCQLCKAAHERSKRTKKHQIIAIDSPITKQVTKEDLGGKHSPKCHKHGNQDMHFYCETCEVLTCAICAAIDHRSAEHKYSEIADAVRLHRKEVEDVLQRFERNREEFIAIGKSVDHARNRLQLMVVRACNDIQAKEEEEIAKIKNKSQILRDKITETGKKRDEEFETVHTQNKNKMERAETIVAAVTELMQQANDLELLNLRPKVMHNLDFQKELTFEKVNHDKSFIGVSCQAIVQDKSLGKILHREKWKLKTEFGKRGDGNGELNSARGVGCFSNSEIIVCDRRNERISVFTSEGHFKSKLDVKAPFGFAVSPDGRLLVNCKDHVKILGASHQLISQFTFSLDDPEEDNRVAFITGGIAAVDNKRVAVMHKGRTVTSLHNLDGSLDTVIPHGGMVPEDIATNTKGQLVFTRYGKSRLSCVDTTGVEVFNVQCTSANGDTAKPVGVCCDGAGDIYVTLHCGNFTGSGEIHHYDPHGVHIACVAKGLYWPFGIAISPRRELVVADQNSIKIFQTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGY3</accession>
    <name>A0A8B7ZGY3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein XRCC1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110986520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022104130.1">
        <property type="nucleotide sequence ID" value="XM_022248438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGY3"/>
    <dbReference type="GeneID" id="110986520"/>
    <dbReference type="KEGG" id="aplc:110986520"/>
    <dbReference type="CTD" id="7515"/>
    <dbReference type="OMA" id="PEWIYAI"/>
    <dbReference type="OrthoDB" id="25840at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17725">
        <property type="entry name" value="BRCT_XRCC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000025">
        <property type="entry name" value="DNA repair protein XRCC1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000008">
        <property type="entry name" value="X-ray repair cross complementing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045080">
        <property type="entry name" value="BRCT_XRCC1_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002706">
        <property type="entry name" value="Xrcc1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370:SF5">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01834">
        <property type="entry name" value="XRCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="326"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="588"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="522"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022104130.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="72669" checksum="F89E98E6230B03B9" modified="2022-01-19" version="1">MPVIKLQHVVSCSSEDTTTHKVDNLLKPESYRKWKCAENAERHASVILQFEKASQIHSIDVGNESSAFVEVLVGHSTSTALDDYQVILVTSSFMSPMESKNGTNTNRVRMFGPDKLSKAAMDKKWDRVKVVCSQPFNKFISYGLSFIKFHSPPTEEDESSTAASQQSQATSRLGKFKLKEDPKTASITPGAFFKQRSITKADPAPLTGAAAVRAAATLAATSLTASATTSQAATASVAPSQTQQGPPKTIPSTAPHKQSDTRTDASQKVTQKRRLSDEDVAPPKRVDTKVAAARRDDADREEGRSKAPPPKKSREESSRQTTKSKSFERQMEGVTFVLSGFQNPLRGDLREKALEMGAKYRPDWGSGCTHLVCAFANTPKFNQVKNKGKIVTKAWILDSYKKKSVQPWRRYSMLSDSDESSSYEEESETDEEDDWEPTKRRKPSPQKATPTKAMPKNATPRKAMPKKATPKKATTRDAEDGDGVGQGASGSPQQAKPSEPDAKEDDNCSTTDIDSDAEEVTITASSRQQDEMSSGGDTEDELRRIQEKGCEGKVTAKDNYDSSTDEEVDIPTAGKPESAAPSLPDIPDLPDFFTNKIFFLYGKFDAEDRRQITRLIVTFDGTVEDYMTDEVSYVITNAHWDENFDKVGATHSINTGFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZI69</accession>
    <name>A0A8B7ZI69_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mortality factor 4-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110986801</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022104702.1">
        <property type="nucleotide sequence ID" value="XM_022249010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZI69"/>
    <dbReference type="GeneID" id="110986801"/>
    <dbReference type="KEGG" id="aplc:110986801"/>
    <dbReference type="OMA" id="GLQTYFD"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000001">
        <property type="entry name" value="Mortality factor 4-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000024">
        <property type="entry name" value="Mortality factor 4-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF48">
        <property type="entry name" value="MORTALITY FACTOR 4 LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="76"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022104702.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38902" checksum="E437107C4E6CC573" modified="2022-01-19" version="1">MAPPKTKFAEGERVLCFHGPLLYEAKCVKAVVKDKTVKYYIHYNGWNKNWDEWVPESRALKFNEANLQKQKELFQAHQAKAKRARAQKKSDKPKEVDKEKEKDREKERERAPTPSAEKPPTKRTKTETAATAVESVSSTPTPEPPRKKRARVDATVENEESFVNKVEIKVKIHDELKPILVDDWDLITRQKMLLHLPAKNTVDSILDDYVKHKKSKKDITPSKESAIVEVTQGLREYFNVMLGTQLLYKYERPQYAEILASRPDEPLSKIYGAHHFLRLFVKLGSLLAYTPLDEKSVQLLLTHLQDFMKYLHKNSSTLFSTSDYETAPPEYHRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJ02</accession>
    <name>A0A8B7ZJ02_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Tumor necrosis factor receptor superfamily member 16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110986889</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104865.1">
        <property type="nucleotide sequence ID" value="XM_022249173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJ02"/>
    <dbReference type="GeneID" id="110986889"/>
    <dbReference type="KEGG" id="aplc:110986889"/>
    <dbReference type="OMA" id="TMDEEPC"/>
    <dbReference type="OrthoDB" id="10048028at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005035">
        <property type="term" value="F:death receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    <sequence length="403" mass="44277" checksum="3DEB650C3136A899" modified="2022-01-19" version="1">MFLRKKAVLICFAVVNWLTYRYLAECTPLPSPECPSKETTSTGDCCLQCPPGWGVQSRCSAFNNTICMHCYADITFSPEPSHTAGCMPCKRCARNEFVRHSCNITHDTLCECRRNYYHTADGSCSQCNTCPPGFGATVKCATQHNTECESCANGTYSDLTSATKGCVPCSTCLEGTVVLEMCTRFSDTVCSDTVMSTTTAYQHSSETPDTVAHVINSRPPSIVPIYCAILAFVVIGLLGYVIFKRWSFRKVKLRSHAKQTRSPLGSPSKADIDVSSAGAHSIKKSADLPPSLAPSRQPTDQTPLMTVPSTTLYRDLSTTTRSEVESLLGISRLDRRDWRGLAHELGFSDKDIVHFIKTSDDDLPVHRMLTVWSDREGAVVSVLVAALKSLNRQDVLQKLPVFA</sequence>
</entry>
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    <sequence length="158" mass="18154" checksum="9FDD93DF36FDE928" modified="2022-01-19" version="1">MIAIPCIILISLQVVYTIYPSKYRSGLEVYCDMDPDYGGWIVFQRRLDGSVNFTRSWTKYRDGFGNWTGEFWLGNQKLRQLTSKNRWKLRIDLEDDQAEHQTYQAKGFSISGDKYTWTHGGSYKAGPLPPHLSGRSFSTYDMDNDEDTNANCAAELKG</sequence>
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZL79</accession>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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            <begin position="23"/>
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        <location>
            <begin position="487"/>
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    </feature>
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        <location>
            <begin position="26"/>
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    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="149"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1358"/>
            <end position="1381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022106373.1"/>
        </source>
    </evidence>
    <sequence length="1381" mass="154815" checksum="07E38C1B75DA4659" modified="2022-01-19" version="1">MAFMDMFVTFLLLVFLLRTEESKLCPSGSDTNMQNIFGVANKQGYFQRGIWHRVPCQSFLSGEELLGVFWFRGSSIEDPNKILVASFSSNRYVYASKRYTFSSEFSLVVKDVKDSDEGGYLCKVAPRHVIDRVGKIDVQVIGNTFPARPSEASTIVSVQRGRRQTLTCHCAPSDAQVSVVYWSVGEGVTADTDIIAARFSDGTFLQVRHGADYSISRNFSLTVNSVSGNNTGRYWCHVFLLNGTRQNCYIEVHVAVGSQTNQALRASATSFYLREGRYQTIPCTTWAPGDEFCLLQWYKVDLSGRRLVLNYSVSTNAVSAVSGFDLSDDYGLSFTSVNFSHAGRYSCHPGYINSSFDDLLDCHVFGEQFPLGSKPSVRGTSVTYEPGKVQILRCPTGLNVTAMSKATLLWSFGARDANSVTVIGRIDIVDGNSTVSELGKICVSISSEGSLHLDDCPQNGDVRYWCHVFANNELWQSYIDVLTQDRAWLTSVIVSAVFVIIAVIAFLIFKYRKHRSNGHQDGYSAIEGTKLKSRGIVEECKEFLRTTLLGLPTIPWLTEDDGCCAWVEDVYSSSELLAIMYVDGRSVKYRIHSTNEIFEDGISMPSSNVLLQGRAGSGKTFILYKMAYDWACEKSESVFQKTKIVFLLPVQVLLETRNVGEAVKKCMLSSKTQFSSENVNEYCVEHLSNVVILVDGCSGKDDVTGAWEVLKEQGLLECQVVMTIRQAQEAEDVCKKYNFRHVLTNGFNLSGHLNRYVEKLLGSKVHDNLLDYLDKDVLPPKLSRLPVVIRVLCLLSSWTNDEAFRDKPTMTDLLTRLVRCLFDSNMEKRKKNFRSMLTKEQLGMVAELGRVIFDKVCEGSGDPFSFSESSFREISRSAQTFIENCLKSGLICRTQEIIRSGETEKIPLAETGSKSHISFRGLVDKPNTETEVSELVPLARTNENVHFIPEILGEFCAGSYLSSAEKGKLLESARKADVDKLANILVFASQRSVACRSEVIEFLVERVSESMNRVQNIASELEVQKVIDLCLQVNFEGKCKCSLNKDLRSMFPEGRLRLFGISRHRLRLLSYLLEHAEGPSTDCNLNLKSIELFRFEQHDWEEIQEYLEEFVPGSIKSTTCKRLHNPKQHLKKEITSRTSKDQMFLHRQSERDSAVLTLESIALEDLRESQSGNCQMSSSSQSFVLSLSHLTLLDSVVLVGSILNPGEICSLANHALRNLPKLKRLDLRLNKEFDDAAFTTVMFSLPQWKSLIDLRLSLFKVTPKGFSEVAVAVKEEGLTLGRLTTFYLLHSQPSDSFAKFLTTSLVYLNNLKSLHISGCVGRDSTMSESALKELEKGMKESQLRGNAEFVVDRMEPLSTRLSSKDKKRRKTEVGQGSFQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLX5</accession>
    <name>A0A8B7ZLX5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein LOC110987739</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106454.1">
        <property type="nucleotide sequence ID" value="XM_022250762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLX5"/>
    <dbReference type="GeneID" id="110987739"/>
    <dbReference type="KEGG" id="aplc:110987739"/>
    <dbReference type="OMA" id="DCYEDSK"/>
    <dbReference type="OrthoDB" id="10001532at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106454.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34204" checksum="388D9A36C5F63204" modified="2022-01-19" version="1">MAKKDPSATLRYIEEVSAQLSDEVRQLRQGDYTKLFKQTRSFVDGLQRSPKGRTTTYGPSITTIASVRDCYEDSKRLDKDRPTHFTSVIGHFLTLVNALRTLAQRVREWIAEPIGELTVHDRQREAARKIKSEMEFWEEFLDEHNDFTDLHKHKTLEEFRGLNTGEVPLWGAVVNLIPVLLKTADGIAELSAKWCSTTHRLGMGIYEQRPSSGAPGSRPESRARGSSATGGQRPKTTPERSCSGDGRKPRKTYADKMDEKYKGRISLLERPPWKPSSQLPHNLYPQLHIHLGDPTNHVPYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLZ3</accession>
    <name>A0A8B7ZLZ3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110987565</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022106082.1">
        <property type="nucleotide sequence ID" value="XM_022250390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLZ3"/>
    <dbReference type="GeneID" id="110987565"/>
    <dbReference type="KEGG" id="aplc:110987565"/>
    <dbReference type="CTD" id="10524"/>
    <dbReference type="OMA" id="QYQRHGY"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000022">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000013">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000002">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="219"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="159"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022106082.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="57957" checksum="4489BB5FE431B77F" modified="2022-01-19" version="1">MEDDLETQQELDPEDLVVEGCRMPVKMANADEWPLAEILSRKEVENRPLFYVHFIDYNKRLDEWVERDRLDLDKMQLPKKDAKTPVKESLSKGNCSSNSRASSPERDMTNGGGGLGAVQRNKSAIGRKRKLPMNDAGAPASQQQVTGIPVIDNAPSPVSAPLSVSPTQLSQGQSLVPSFSQSTPDFFSQTSQPEPVPPAHAPRQTGSMATDKTHDDIITRMKNISMIELGRHRIRPWYFSPYPIELTVLPIIYLCEFCLKYVKSRKCLERHKVKCNLRHPPGNEIYRKGNISFFEIDGRKNKSYSQKLCLLAKLFLDHKTLYYDTDPFLFYVMTEYDNRGFHIVGYFSKEKESTEDYNVACILSLPPYQRKGFGKLLIEFSYVLSQFEGKTGSPEKPLSDLGLLSYRSYWSQTILETILKLQKSADGERPQITINEICETTSIRKEDVISTLQHLNLINYYKGQYIVTLSPEVIEGQEKAMVKRKIRIDPKCLHWNPKDWSKRGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMD1</accession>
    <name>A0A8B7ZMD1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106050.1">
        <property type="nucleotide sequence ID" value="XM_022250358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMD1"/>
    <dbReference type="GeneID" id="110987547"/>
    <dbReference type="KEGG" id="aplc:110987547"/>
    <dbReference type="OMA" id="FMFHEDK"/>
    <dbReference type="OrthoDB" id="10006207at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106050.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36519" checksum="264F88D9BC190C85" modified="2022-01-19" version="1">MPEQTVSKSEGTQTDSIPFIFSLDPAYIEYGRSGLLLLVFLVAMWARNRRTWILVDTVAVCVFGLAFMFIPEKLLTFQVVSKVKIEGIIVMLCRTFGSFMIGSGLSWFFLRKSTDNYTQVMLLATRVVGNSALLVSMYVARTQGKLLNEQFVRFGVLGAVLWTLGSALYFLAAKNYGGHTQLDSWLNFHLRFDFFLSLMFGLFWYSYPALVLKMHVPESTVKINDVHVLLEQAVGAMLIGSAILSAVAPGFMFHEDKRNVLLCRILTIILVVVTSLSSLDHSDIDKSVMLGHLVGVTWLINAGLGYFAPHETDGYWSGRNRANKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMT2</accession>
    <name>A0A8B7ZMT2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Low-density lipoprotein receptor-related protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110987701</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106372.1">
        <property type="nucleotide sequence ID" value="XM_022250680.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987701"/>
    <dbReference type="KEGG" id="aplc:110987701"/>
    <dbReference type="OMA" id="VNPCKVN"/>
    <dbReference type="OrthoDB" id="72419at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000001">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF41">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034224208" evidence="14">
        <location>
            <begin position="20"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1390"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="70"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="203"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="381"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="424"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="467"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="511"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="600"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="683"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="726"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="811"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="901"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1216"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1493"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1570"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1600"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1493"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1573"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1635"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1280"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1298"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1305"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1317"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1336"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1356"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022106372.1"/>
        </source>
    </evidence>
    <sequence length="1647" mass="185327" checksum="ACD66B3304A168FD" modified="2022-01-19" version="1">MAWLWILVLVCCLRAQIRALPPELVFANRKDIRILNFGMSNDSDVATTESSIIIGNLEDAAAMDYLFSEQLIFWTDVSIEMIKRMRYNGSQIQEDVISTDVKAPDGLACDWVGRKIYWTNTETNRIEVSELNGQSRKVLYWQDLDQPRAIVVHPERGLLFWTDWGEIPKIERAGMDGSEHYRKVIIDTNIFWPNGLTLDYDTSKLYWADAKYSYIHRCNFDGGNREQVLQGSLPHPFALTLFEDTLYWTDWETHSIHACNKMDGGNLRVVHEDLFSPMDIHSYSPLRQKEVSRLCAVNNGGCSHLCLMSPDPPFYACACPTGVRLQSDRLTCANGAQEILILARRRDIRKISLDTPDYTDIIVPLEDIQHAVAIDYDPVEGFIYWTDNDVKAIRRAKLDGSASEYIVTSDIDHSEGIAIDWIARNLYWTVTGTDRIEVSRLNGTSRKVLISEGLDEPRAIAVDPMAGLIYWSDWGEIPKIEKANLDGTGRSVLINTSISWPNGIAIDHQEGKIYWGDGKEDRIEVVDMDGSNRRVLVDNEIPHIFGFSLLGDYIYWTDWQRRTIERVNKHSGEDRQMIMETSDVMGLTASSVREVQGHNPCGTNNGGCSHLCFYLPPSIICSCPIGYELLADQRTCIIPEAFLLFSLASDIRRISLETNHNDVEIPLTGVKEAGALDFDINDNRIYWSDMDAKTISRAFLNGSGIENVIEFGLSFPEGMAIDWVAHNIYFSDTGTDRIEVARLDGSARRVLVWERVQSPRSIALHPSEGYMYWSDFSGQAQIERAYMDGTHRSVIYRGGRANGLTIDYLERRLYWTSLDTNTIESADLLGGSRRRVIPDDLPHPFGLTQYQDYIYWADWETQSIERANKTNGLNRTLIQDGLEYVLDILVFHSSRQSGWNECAVNNGGCQFLCLSHPNVTTGEWDYVCQCPTHYTLNEDGQTCTPPDRFLLFSQKNTISRMAVDYRNSPDVVLPIYNSRKNIRAIEYDAQEKRVYWINTRANTVRRSYDNGVQPEVFIPNSGDPPVYNPYDLAIDPYTRMMFWTCSETNTIRITRLDGTPIGVVKGDDNQKPRAIALIPEKGLMFWTNVVRTQHKIERASYDGTEHTVLFSVNLGELGPITADPSSETLFWVDTMLKRIESAHISGSDRRTLVEDHILLPKGLAVLGDHLYWVDRQAEIIARVNKYSGSGWVRIQGETSYLTDIQAVGMPLQADHPCIDDNGGCSHICIAMGDGQSRCSCPLDLVLQEDESTCGDPPTCSTKEFTCVSDSNLCVPLSWRCDSDFDCDDHSDEEDCPFCKPNEFRCDNGQCIDMVLRCNSKNDCSDDSDEQYCTAPCRANQYECVNKQCVDVENPTCDGVRHCYDGSDEKNCDENPQETPTINKPPEMSGAVIGSIVALIFVIFIIIGLIIIFRHCRCGTAQGGMAGRGAVDNGQYSTVLMVNQLGGRDSSSKYLSGSARCSNLKSTNLHSCANGKSGSSSSCGGLFERAHPTGASSCSSEMSVSGNSNYPKETLNPPPSPVTDRSQCMADLYYPPQNPSTSRSYRHYKMRNIPPPPTPCSTDFCEDSEPYVKTPHHQKHHATRRKRGNKYYTNVTNFDVAYEPEPYPPPPTPIMSDNNYESCPPSPSTERSFFNPYPPPPSPATDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZN94</accession>
    <name>A0A8B7ZN94_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mediator of DNA damage checkpoint protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106904.1">
        <property type="nucleotide sequence ID" value="XM_022251212.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987989"/>
    <dbReference type="KEGG" id="aplc:110987989"/>
    <dbReference type="OMA" id="KSERPYM"/>
    <dbReference type="OrthoDB" id="2121618at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35538:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35538">
        <property type="entry name" value="LIG_CHAN-GLU_BD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="905"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="943"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="962"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106904.1"/>
        </source>
    </evidence>
    <sequence length="1626" mass="184406" checksum="44CEB34A8B894EAC" modified="2022-01-19" version="1">MAFPLLNQLVSYPDPLQPEVPTGDETDTTALASETVEDREVSNAEEDEKAENDDENSSSRRLPSIVSIREFQRPPPPGTIQASWLDTSYQKALARVRERIVGQGKGPRNAEEWRYHKAPAPARPDLTRTFPLLMRNEVNKNNPRKRNKHRRSGTFPRAASDDVDDESKVAFLPPLPVHTLYQNLFHDLSSSFPSTVLSKKLRSIQDNNIYHHTYLPFVGTASLHPKAYSETEVREKPYVLPALCPGCRGDVGVTVDFRGLASVDKDEGIGSEIESQGIQGQDDVEIELVKDSAVTLQMQSICFGCALSSTPHYHHSKPRRVGGGFTFFSKEPPKYVLVPKEDVVTKETRLPDSSLLYSSENLTLDDDLRMSVEKLPEPEGPVHEMTVPRQKPTKVPQWILDMVHHHGDRNHKVKHYQDHCYACLQVLRQLLPDYNPKDFSDCSSSGIGTSVMSEATRLEEEARIEEEARLRMEARAREKRRLEEERLRREEYERERRKHLYKAPKAFQPKKSEVKVTETQDPFSKERMLDVPKNEGFKVQKSTKPPTKTVETRREEKIWKEPERFELKKPAPKAASAVRKPPERKERLRPETPPPPPPPPVAKKPTIPIQPKKREVAEPIPSLREPAEAPPKKQLEKAKFVKPPIKKVEKELLPTPAPPPMPVRAKTPPPKKKPVARAVTPPPKPVQDPPKVIERTKPVLKEKPKPVQKEEMPPPPPVKKIAKTEKVDRKPKVVQKEEKKQPEKVVVKKKPPPKEPAVIPKKEVKKEPPLVKHMTPPPPPAPPKDSTPEPTPPPPQDPTPPSPKESTPPQTPTPTPPPAESTPPPPKESTPPPREPTPPPKEPTPPPPPREPTPVELIPPLPPKDPTPPPPEPEPEPVIIKRKKPPRPRPQRKKPPKPVKKAKKKEPEVPLKSERPYMDIPQVPFRQPAPEPNLPKEPSPEPEVLEPEPEIEPELEPEPEPPKVPTPILSPPPPPPKEPEKPTPIVKPSKKTRNAKLPKPAPVKKPMAVKAKKIPDKRKKPKPFVMPVQKKLEHEEPPPFPATPEPSEPMELIIEVPPSPTIPTPESPKEPTPLPEPPPLTPPEILEPIVMKRRRVQYKPKKRRWRKIEATPSDGGSPEPVLVDALDYLAKYCIVHKQRIPHYQHIFTRALRQKGIQVEETVPPSVPTVARLTAHNNNPTILNSREGVKLDHDNASVTTETSGYASVVNDDPVSSGDDFQSVFGTSKTINEEDYVSPINLTTSLKEGSSGDEVESRGNENQKPTGFFGTTMFATEDYIDKLSFQLENLYKKLNTLQLRVLELSNEKRRIVANFTRKEFPEVLRPGFDPNVVEKKSPKGKKQKGEVQFISVVEELGYLNPDEGSREEVHPENDDWVLSRLTNRHWQMLESDPSVRRLDLERERAQEKYDFAQERIAALLDEKTRASLQENVLKRQDLLSRAATNDDFRRKQSVLYQQMNPVQNFEVDVKDLESTLKQVNSYLITEKECQYIYHVLDLPQRHRIDFKLFSVVAALSEKVSRLEPFIRKLINKMNFEALEVKMQQAKELFFLLADEDDEADGGEVPIQNLVVELEAGGLKPEHVKLVVEKFNREGKGTVDFLDFLTYIPLFIDIHENIISDPLNLSRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNK7</accession>
    <name>A0A8B7ZNK7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110988188 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107183.1">
        <property type="nucleotide sequence ID" value="XM_022251491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNK7"/>
    <dbReference type="GeneID" id="110988188"/>
    <dbReference type="KEGG" id="aplc:110988188"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034510527" evidence="2">
        <location>
            <begin position="21"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107183.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24511" checksum="14AE402FBA68057A" modified="2022-01-19" version="1">MLRVSFLCLLYLLLFGTAEANWGDGSRDPDHSHLGFVAVNMICNDNRSACGHCYSARSHGLVYLSTMCLSTLQRLTNLKRASKTASRIGTGRSSKTIHRSPSVSAKKSRCPPPQSCRCPCAPPSAWTTTSAPSACQGIVPIRWSPSAWTRTSPTRRSTVCKHFTAYPSRRRLFSDSGLLHVGSSWNPGLYSNGIKVLIDFQQRLLSTLYHALFSTFGYSLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNV5</accession>
    <name>A0A8B7ZNV5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">GA-binding protein subunit beta-2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13" type="primary">LOC110987802</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106578.1">
        <property type="nucleotide sequence ID" value="XM_022250886.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106579.1">
        <property type="nucleotide sequence ID" value="XM_022250887.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106580.1">
        <property type="nucleotide sequence ID" value="XM_022250888.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106581.1">
        <property type="nucleotide sequence ID" value="XM_022250889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNV5"/>
    <dbReference type="GeneID" id="110987802"/>
    <dbReference type="KEGG" id="aplc:110987802"/>
    <dbReference type="OMA" id="CIHISTA"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000025">
        <property type="entry name" value="GA-binding protein subunit beta-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF128">
        <property type="entry name" value="GA-BINDING PROTEIN SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022106578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022106579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022106580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022106581.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43186" checksum="44032378A2869E3C" modified="2022-01-19" version="1">MMSLVDLGKKLLEASRQGLEDEVKILMANGAPFTTDWLGTSPLHLAAHAGHVPTAEVLLKAGVSRDARTKVDRTPLHLACQEGHKEIVQLLIEHGADVNAKDMWRICQLKMTPLHWAVERLHAPVVKVLLENGAALDNFNKFDKTPVDIAADHQNEEVIAILEMAQGMGSEVTIEEAPCVYITTDGDPSVTISPTPAATALQSFVTAAARAKSKASCKVVTKVPTTASSTSVLATLAALAEASTPLNKLSAHSNRSNSLYGTSGESLQMYTLTEAGKLAMQWKKFSNEDENRKQDIDSSESTQKVITIVQTTEQEPEITSNSSSCDSTPVTLAFVGEDLNELKTANTTVDNSLHQQLQEAQKQAEIYKQQLAAKEREAEDYRKRLQEISGSKDLQNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPJ6</accession>
    <name>A0A8B7ZPJ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein PAT1 homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PAT1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107339.1">
        <property type="nucleotide sequence ID" value="XM_022251647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPJ6"/>
    <dbReference type="GeneID" id="110988286"/>
    <dbReference type="KEGG" id="aplc:110988286"/>
    <dbReference type="CTD" id="219988"/>
    <dbReference type="OMA" id="QAPMFRA"/>
    <dbReference type="OrthoDB" id="74835at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019167">
        <property type="entry name" value="PAT1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF0">
        <property type="entry name" value="PROTEIN ASSOCIATED WITH TOPO II RELATED-1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09770">
        <property type="entry name" value="PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="mRNA decay factor PAT1" evidence="9">
        <location>
            <begin position="616"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="381"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107339.1"/>
        </source>
    </evidence>
    <sequence length="928" mass="104052" checksum="EF56C22C257C4090" modified="2022-01-19" version="1">MTEFMFGDDPEMPPLEEGPDDEYDELNDETFGGDFEGDWQDTHEKFSAGFGNTSFEDDYSTKRPHDSGCYTGERARMHEENLEESISKLVLDDEDDEDDMYTDKSSAKKSQPITIGNGASMGNSNMAQLFGPSSPPALFDPQEFISPGSRKNIWGSPTTKKVTTNTEQHLKAMLNIHPPEELPLEDPAVIQAIASTEPAKKVLTLEELEKDLTDRAPPQRTVSPILGSPPASRMMPVGTPPQHSLLQRTPAGVVHQHQQQLKRQQQQQQQVMQHLQSKSSGQPMTPQQQQQQLAASPAVQQLVQKIHQSVGGRVSPTYIRQLVLSMQAANGRASPNQIRQLIMANSAQGSASPFPRPMAAGMTPPAKGMAPPTGGPPPTRTPMQQQPQHQQQHQQQQQQRFGSPMMQQRPMSPMMHQQRQGPPMMQQGRTSIMPFPPGSVIGGPHLRTPQGVRGSGPGRAMNTYLTPMHPHIPPMRPFSDPGLRRRYPFNNQQRPFSQTPNRYGDNRHQRPHHNRYNEQRRPGPGGDASTDDYANLMTQREKEWVQKIQLLQLQSNNPEVDDYYYQAYMQKKQGQEEQGKEGVQAEKTKKNGKESGKITPNTKSLETRVYQPAQYEGALGRVTSSSVNNPRQLIDFHIEAVGDEEEGTKPSAAKEQSKKRRTLLSIERVYGILLQLDDLGKQVLTLTESDRRTLLEKRQSLLGVVYAHLKPETVLCDRPSDDHFIQVLSVRKGRRLITRVLPLLEKKEAQYVVQALLRNMSLLLKKESQEMRKELQETQKASAQETLPAVFPPVWRCIQATTLPELTCMVKQLTAGASSVSPSRQYGSIISLHMQNKFGVSVILCLLSQGERIYSSTSLVDLEEDAQNDWVDCVNQFAKDICVVADTAIPQPLVIVDNVLPHFARFVSKQTFNALEKRLRSITTDKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQ36</accession>
    <name>A0A8B7ZQ36_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">LOC110988182</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="RefSeq" id="XP_022107172.1">
        <property type="nucleotide sequence ID" value="XM_022251480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQ36"/>
    <dbReference type="GeneID" id="110988182"/>
    <dbReference type="KEGG" id="aplc:110988182"/>
    <dbReference type="CTD" id="36"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
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    <accession>A0A8B7ZQJ8</accession>
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        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
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        </source>
    </evidence>
    <sequence length="438" mass="47126" checksum="B1813F4791E8EAD5" modified="2022-01-19" version="1">GNNLLLTVSNAVDIWLEGGTPPSKLVLGMGLYGRSFTLRGQQTGIGAPVSGPGTPGVSTREDGFLSYYEICNKLQDGQLTRVWDVRRRVPYAFHGNQWVGYDDKRSIRVKVDFLKEKGLGGAMVWAIDLDDFNGDCGETWPLMKAINRRLAFDATSSPATDELVTDPPATDAPATNAPATNVPATEISATDTPATDARITDALATDALSTDAPATNAPAGDVSATNVPATDGRITDALATNALSTDAPATNASSRTHSPDAGTFTCRDKPNGYYADPNSCRMYYICNQGVASYLPCGTGLYFDPQTYTCNYPGNVQCNAPDTPLFCDDRADGHYADPADCSKFYQCANGFTYLTSCQDGLLWNSHINSCDWPRNVKCDRNEVFSCDGREHGYYGDPSDCAGYYHCAGGKTYRFSCGGDLYWNAQVGGCDYPSNVQCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZR67</accession>
    <name>A0A8B7ZR67_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="5">3.4.24.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110988415</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Cleaves proteins, imported into the mitochondrion, to their mature size.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="20">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022107562.1">
        <property type="nucleotide sequence ID" value="XM_022251870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZR67"/>
    <dbReference type="GeneID" id="110988415"/>
    <dbReference type="KEGG" id="aplc:110988415"/>
    <dbReference type="CTD" id="4285"/>
    <dbReference type="OMA" id="ALMFEYM"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000013">
        <property type="entry name" value="Mitochondrial intermediate peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.10:FF:000026">
        <property type="entry name" value="Si:ch73-1a9.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 20" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 20" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 20" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="21">
        <location>
            <begin position="256"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00059424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022107562.1"/>
        </source>
    </evidence>
    <sequence length="703" mass="79600" checksum="5A98A6CC5931B770" modified="2022-01-19" version="1">MSAARLGHLARFTNSLLRPTQYIVGSRPDPCHKYQRVTTWSPLASAFNARPKRQLETSGQNVGLFGMPELTSPGGFAEAQRVSVQEAEELVQEAIRSPTSAHIVVLFDKLSDALCRVADLADFVRVAHPDQRFARAAEDACVHISAMVEQLNTNVDLKESLQRLLDDTATFSAMDEESQIVARLFMFDFEQSGIHLEQAKRQEFVRLNEVIHILGSQFVQGTQTANAIEKRRLPQHIQHSFAVDGENVAIGSLYGDNPSDLVREAAYKIFLFPNPTQSQLLDRLLDSRHRLASLVGFSSYAQRALRGTMAQTPDNVMQFLTSTGDRLFDRVSKEIELMKEMKKECNPFNPDIFAWDPSYYIGAVRNKRYHITNSEYAPYFSVGACMDGLSLIFSKLYGVTLENVEAERGELWAPDVLKLAVTHETEGVMGYIYCDLFERPGKPQQDCHFTIRGGRRLDDGSYQLPKVVLVCSFSPPRQGAPSLLSHGMMENLFHEFGHAMHSMLARTRYQHVTGTRCATDFAEVPSILMEYFANDYRVLKEFARHHKTDQTLPEEMIARLCTSKKQFAAFDMQTQVFYSILDQVLHGEHPLRKTTVEILSEVQNQYSSIKHVPGTAWHLRFGHLVGYGAKYYSYLLSRAVASSIWHKCFAADPLSRDTGERYRWDMLAHGGGREPTLLVQNMIGKKLSNEDLVRALLEETEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZS09</accession>
    <name>A0A8B7ZS09_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC110987642 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987642</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106236.1">
        <property type="nucleotide sequence ID" value="XM_022250544.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987642"/>
    <dbReference type="KEGG" id="aplc:110987642"/>
    <dbReference type="OMA" id="SGNHNFC"/>
    <dbReference type="OrthoDB" id="10436942at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034192796" evidence="8">
        <location>
            <begin position="25"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1404"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1438"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1463"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1507"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1548"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1592"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1617"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="28"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="12">
        <location>
            <begin position="179"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="12">
        <location>
            <begin position="334"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="12">
        <location>
            <begin position="502"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="12">
        <location>
            <begin position="670"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="12">
        <location>
            <begin position="838"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="12">
        <location>
            <begin position="930"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="10">
        <location>
            <begin position="1243"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="1402"/>
            <end position="1641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106236.1"/>
        </source>
    </evidence>
    <sequence length="1708" mass="185090" checksum="3464CBAE21624F08" modified="2022-01-19" version="1">MELCAVKLCAVLIVSWVFAMHVEAVEFCGVPLGMEDGRIPDSSITASSTFTPTTCLTRNARLNNPGSPWTESGWCPSNSDRTNPWLQVDLQRPTKIEGVIMQGVVGGLGVTAYQVQYSNNQTGWRYVGQNEMGSGIVETFRTNVGSSGPPVTHLFPSPVKARYIRIRPTEYNLLPAIRMELIGCQVLDCPSNITQFAEISSTAVPVSWEEPPTADSLPWNATHRPGDLFPVGSVTEVAYTAQNDEEGSFISCSFTVAVTGVDITCPGNVSVSTNVNNFANVSWPLPRLRFSGVNPDVRVISNYEPGQGFTIGTTLVTYRIPETKAECQFYVSVLDNQPPVIRDCPDDVIVPVNSSSGQLSVSWSPPSISDNSGRDIQLTFKCRATTPTECNEAGEGTFSVGITTVIYKAQDQSGIESVCQFTVNVTVVNLACPQNVTVTPNPGSSRASVSWPEPILTGWDGPTNVASNFNPGDMFSIGAEKVVYRHRFEAFSFECSFFVQVLDNEPPEINGCPDDVIIPVGSSSSRVPHVWTPPLITDQGEVNVSFSCQALAPTECYQAGDGIFSEGITIVMYKAQDQSGNENVCRFVIEVTVVNLVCPANVTAFANPGSTRTSVNWMEPDLIGWNRPTNLTSSANPGAVFMIGTHRVSYQQWFGEYNLRLGCSFFIVVVDNQPPVITSCPNDIIVPVNSSSSQQSVSWFPPSISDNSGRDIEVTLDCLATAPTECNEAGEGTFSVGNTTVIYKAQDQSGTESICQFTVIVKVANFVCPPNVTVTLNPGSSRTSASWPQPVLAGWDGPTNVTSNFKPGDMFTIGTEKVDYRSSFELYNFQCSFFVHVLDIEPPEIISCPDDVIIPVGSSSSWVPHVWTPPLITDQGEVNVLFICQALAPIECNQAGSGTFSEGVNTVMYKAQDQSGNENVCRFVIQVTVVDLVCPENMTALANPGSKRSSVNWMEPDLTGWNGPTNLTSSANPGSVFMIGTHRVSYQQWFAAYELGLDCSFSVMVVGRCPSNSTSDGLRWPAVTAGSTAKSVQRCALTTAKAGQPLAVRNCSIENPPIFFQWEEPEPRSCGEAKNEVSLDNVARVDVSEGNVVEVAEFLANQTSESTKDAENVGAVSAILVNVVSTRSGNKEVAELVVQTVSNVIKSTETTADSKTPDINAGNSSAIIRSVEAQVSLTLRKEGKVSIRQDKVHVEAVSLDPEKASGGFSFVSARQAGQELPRDGSLGGAEVNTFFDTKDIPADIEVVASVRLPGNIADSIYPSDGNNSVQLQASFLIYADDTLFQSASLRKYRGENNSTRKVAGSVVSLTVENVELVNLTEPLVIEFKTPNNVTDEELQTIQCVSWDFNLEDGVGDWSPAGCERAGLTADKMSCDCYHATNFAVLLDVKGQVPEDTPEKKALDVISQVGCALSIVALAVTLIIYLSIRKLRSGISRQIFIHFCFSLLMLYIVFLAGIDNAKGSGGGCVFVAALLHYLTLSTMMWMAVEARNMYISTVKVFPEDRPRYMLKACLIAWGSSLIVLTITLAAGTNHYKNDHYCFLRPGLVLYIGLLTPIGLILIHNIITFVLVMRSLLKVKEVSRSQQISKRLQNAVGISALMGLTWCFGFLAIEGATFIFQLIFCLANSLQGVVVFIMFCARREEVRLALTPYVRRICCGRECRLPALHPVKSKDVEMISTTAPTVHSTGQTGQFDLSISIPNAPFESDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZS33</accession>
    <name>A0A8B7ZS33_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitogen-activated protein kinase 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108214.1">
        <property type="nucleotide sequence ID" value="XM_022252522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZS33"/>
    <dbReference type="GeneID" id="110988732"/>
    <dbReference type="KEGG" id="aplc:110988732"/>
    <dbReference type="OMA" id="YSCIRDE"/>
    <dbReference type="OrthoDB" id="8806754at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008350">
        <property type="entry name" value="MAPK_ERK3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01771">
        <property type="entry name" value="ERK3ERK4MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="494"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="562"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022108214.1"/>
        </source>
    </evidence>
    <sequence length="615" mass="69219" checksum="27F156164F458D91" modified="2022-01-19" version="1">MYQLLRGIKYLHSANVLHRDLKPENLLINLEDLVLKIGDFGMARILDPDYSHKGHLTQNVSTRWYRSPELIFCPSDYTKAIDLWSAGCIFAEMLGGKPLFPGEHDLDQMLLILEMIPINEVDLVEVEGSIPRKMLKNYKGTPRISLCDVLPSVELDAMDLLKSLLTFDSNERASAEEAISHHYLKLYSCASDEPLEADPFRVECEVDNLSPVTLRKIIFIESQAGYDSGHQLLPNALRLWTANDSEDDYKRKLELLNFSSRDNSDLDSEEELCEKLDSDKTSPEELGLSVLDKNTDSGNEASEKFQEETKERKLLQWEQNVTGRETSDEVLEKGTVESDGESSEKSEAEVGKTEKDMEQEVTPAQSDQDAADESLEKHISAFPPKFNKNAFLKSSLETENGEKQPAKEQGFSSDLPEKAIGDKLQKEKQEKTPSIESTKESQVPANAEQSVRRKERENKELLNIHTSQLTNNKVLYNEEKTLQQCLAKSCQVEDIPGSQNTNIPPRSNDSTSQEGSTLIPPQVALSSSNVGVKSVRHVAHERRSLSRPVGFDEMLFVEIPRNSSSLPGSHWSPPRDAEKPSSVQSPRSRGSNSPREKSVRPKKQDWFYMHKGSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZT55</accession>
    <name>A0A8B7ZT55_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110988761</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108252.1">
        <property type="nucleotide sequence ID" value="XM_022252560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZT55"/>
    <dbReference type="GeneID" id="110988761"/>
    <dbReference type="KEGG" id="aplc:110988761"/>
    <dbReference type="OMA" id="EFARCPQ"/>
    <dbReference type="OrthoDB" id="6132489at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35842">
        <property type="entry name" value="SI:CH211-67E16.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35842:SF1">
        <property type="entry name" value="SI:CH211-67E16.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034173318" evidence="1">
        <location>
            <begin position="33"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108252.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="60857" checksum="5245E14252324FEC" modified="2022-01-19" version="1">MWRSEEAAMEFLRCSFLSSILMGLVLMKQGQALVDNSFRLSSSESAAATTIRMTTSLSSASPVLPDPRLSHWARAASDFLRSLDCAAVTFTSQTECQRLQTMDTKQMSVYLAGPRSRQRMIAVLPDGGLSRGRSHDAVLVIDPYPAASFGHLVLVFSLDLDSDWEDCRNRLGWYIGDGECIHILEKRRCRNKLHRKSGRRRCEVNFLPLVHLEGDSKKEQQLRCFSNTGSFGSCPQYRTDVGNYTNRCELSHNTYRCEIPVQHVNSRCKYYEICDQAVLISGGWNRQISQQRHAQNIRGMYSMLREHGFKRPNIKTFFADSGDILLEEDEHSNRNSYPATQKDAIRNHISTLCRVPNCVETLVIYLNSPTTNDGTSLLWDTDNNGVASDAETYSTMELLEDLEDCRAKRIYVIADQSYSGLLAESIIMSESHGNVVVFASSGSTEYAWNDELTWQWIQANHTTQCVDVIFEDYMDTLSSVPAMAEGGFNAANSTIFGAPCETLPFFTPREIKTNFMGCQNLPMAWWLFKFQESRNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTP1</accession>
    <name>A0A8B7ZTP1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">28S ribosomal protein S27, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108442.1">
        <property type="nucleotide sequence ID" value="XM_022252750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTP1"/>
    <dbReference type="GeneID" id="110988844"/>
    <dbReference type="KEGG" id="aplc:110988844"/>
    <dbReference type="CTD" id="23107"/>
    <dbReference type="OrthoDB" id="19830at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034913">
        <property type="entry name" value="mS27/PTCD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019266">
        <property type="entry name" value="Ribosomal_mS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10037">
        <property type="entry name" value="MRP-S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108442.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47916" checksum="CEDEC3978F395BC7" modified="2022-01-19" version="1">MALYRRACVRALTSLLQLQRPTWVKSLFPISEATVRGNTVIGQRTLLTDAYKGTSAWRTRKILATNMDELKITLDADFFDFKKPVASVDLHKFMDNISDEHDLKSAEQYLYCHRHSSVAHHLRASTMHSFIRTCLDLGQADTAVKVLQDKTNYGVFPDNFTFNLLLDDYLERGDIKGAAAVAMEMMTLEVLTDEEPLSRLLALYCCHRYLKSGDSAREVMHDLGMTFADATRGQTSLLSSSYHALGLVMAGRLKQAARFLQAEAERTGDGGPCLVQEVVEGLLAVPEEQPDVEEELRGQLQECVSRLQAEGRISAESLDSLVTTEILPEIQRLQADHTHAEQYPEMLAEWHRQHVEAVRRQIRAAQEYEMSLKKKKLEKLLEATGGLRYWLQKEERRKAAADAEAGKEQSGETTEEQELDKQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTW7</accession>
    <name>A0A8B7ZTW7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110989069 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110989069 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110989069</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108868.1">
        <property type="nucleotide sequence ID" value="XM_022253176.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108869.1">
        <property type="nucleotide sequence ID" value="XM_022253177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTW7"/>
    <dbReference type="GeneID" id="110989069"/>
    <dbReference type="KEGG" id="aplc:110989069"/>
    <dbReference type="OMA" id="NAICPFY"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108869.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="28390" checksum="CD17459462FEFFC0" modified="2022-01-19" version="1">MSSLKGKVALVTGASSGIGAETARYLASLGCHLSLTGRNESNLKTVSEECQQNGLPADKILLIIADLGKEEDVKKVADKTIEYFGGLDVLVNNAGIVIPGSIETVTVEQFDKTFDVNVRAPLQLTHLLRPHLIKTKGAIVNVSSVNGIMAFPGVMTYCMSKTALDSLTLNSAHDLAPHGVRVNSVNPGVIRTAVHKRGGMTDEQYQQFLKKCERTHAMGRTGTVDEVAKVITFLASDDSSYVTGELITIDGGRHLLTVMAPEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUC4</accession>
    <name>A0A8B7ZUC4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988824</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108395.1">
        <property type="nucleotide sequence ID" value="XM_022252703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUC4"/>
    <dbReference type="GeneID" id="110988824"/>
    <dbReference type="KEGG" id="aplc:110988824"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="101"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="353"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="399"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022108395.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="55485" checksum="C87F84A8D4A6B54E" modified="2022-01-19" version="1">MCRIPDVSLVVFNNKTQSSSWASDYSNILQCSTNNMASNSGGMNPEHAEAESENTSHSTSEVEEEMEVVDPENSDMEESDGEGGERRVYLPGDPLDEGEMLVRDDSAYHMYHQAQTGAPCLSFDVLRDSLGENRTSYPHTVFAVAGTQAEKAHLNNVIIMKMTNLHRTSQKDDDDDSDEDSDSDDEDSKPELETAMLKHLGSVNRIRSTDIGQKQVAATWADTGTVHLWDLTSALQAVNNAHLMGRFMRQESHKPLFSFTGHQIEGYAIDWCPTASGNLITGDCRRNIHLWKLQEGGEWSVDQRPYAAHAESVEDLQWSPNEKNVFASCSVDKSIRIWDVRATPSKACMITMKEAHSSDVNVIHWNRKDPFILSGGDDGVLNVWDLRQFQKKAPPVAKFKHHTGPITSVEWNPQDSTVFAAAGSDDQLTLWDLSLERERETAPEGESGQSRLDGIPPQLLFVHQGQSDIKELHWHPQIPGVLISTAHSGFNIFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV60</accession>
    <name>A0A8B7ZV60_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110989312</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110989312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109304.1">
        <property type="nucleotide sequence ID" value="XM_022253612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV60"/>
    <dbReference type="GeneID" id="110989312"/>
    <dbReference type="KEGG" id="aplc:110989312"/>
    <dbReference type="OMA" id="NCANCHI"/>
    <dbReference type="OrthoDB" id="10067955at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF14">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022109304.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="31961" checksum="8E8403AB19A9BC9E" modified="2022-01-19" version="1">MESTSLSLTKEVLAERKRLETAVEGLQPQIQIGVFKLEELRREQQILEQHEAEIQANESFEYEVEVPKSKMVNITGYITNCSKCHYSCHYPCGIANDNEKDGCWAMSDGKCRICPGNCVWNVHFNQGYKFEYYSEKEKRTYAELEERYKDATGKKLTVEQVIRKHYDEFLSVQKCVFVLITDSHHSLKRLEEIALKPNPLSTVEYVDLLIESEKAEAKPGWKFRVKALEDVRNQADIMTKVKKANYDPFENYKKEFLGKKSSKHGKSWYQFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVC4</accession>
    <name>A0A8B7ZVC4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110989439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109508.1">
        <property type="nucleotide sequence ID" value="XM_022253816.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109509.1">
        <property type="nucleotide sequence ID" value="XM_022253817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVC4"/>
    <dbReference type="GeneID" id="110989439"/>
    <dbReference type="KEGG" id="aplc:110989439"/>
    <dbReference type="OMA" id="IKESECM"/>
    <dbReference type="OrthoDB" id="10033535at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF519">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022109508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022109509.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25599" checksum="4D4A9611377925A9" modified="2022-01-19" version="1">MGMRDCAKSVLFIFNLLFFMTGVAVLAIGAFLYSREGPFATLLPSLPFLNVTTMTMIVGCVIMIVAFLGCCGAMKENVCMVSTYFIIMVAILTAELIAGGLGFANRNAVEAFIEKDLTQRGIPLYGTKGEHGLTSAWDRMQTSLSCCGVNNSTDWSRFHPLMTIPGETPDSCCSEHLVTACGRDNDVSKWEKGCKEVLNGEIKSHMGVVAGALIGVGVFQMLGIVLSFMLCYSIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVP6</accession>
    <name>A0A8B7ZVP6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Coiled-coil domain-containing protein 103-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC110989420</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Dynein-attachment factor required for cilia motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DNAAF19/PR46b family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109489.1">
        <property type="nucleotide sequence ID" value="XM_022253797.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109497.1">
        <property type="nucleotide sequence ID" value="XM_022253805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVP6"/>
    <dbReference type="GeneID" id="110989420"/>
    <dbReference type="KEGG" id="aplc:110989420"/>
    <dbReference type="CTD" id="73293"/>
    <dbReference type="OMA" id="YRNWRRH"/>
    <dbReference type="OrthoDB" id="447931at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007368">
        <property type="term" value="P:determination of left/right symmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042422">
        <property type="entry name" value="CC103"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031733">
        <property type="entry name" value="Dynein_attach_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28572">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28572:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15867">
        <property type="entry name" value="Dynein_attach_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein attachment factor N-terminal" evidence="13">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="12">
        <location>
            <begin position="103"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022109489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022109497.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30101" checksum="3AF5D5156D8A6079" modified="2022-01-19" version="1">MAHLKEDWIDFGKLEKELDEAVQKDARYWRENDAKFRAVEQRVETYEQFRDIVKAAHIKPLDKKDKIGEGKRNQPWNPYTSKTAGQEHPKQDEFSRKESNNLPKTSHEFIQSWKTLGDAPSEKYHLLTGLGSEQLGHIFRAEIGFGLLGDFMTVLNQQFRGSDCHCIVGILESLSRTNRFGLSVGFLSKPERQDCLELFQKLQEASSCLEKNSTSAFASSETKTKDVLPETRESGKLQPCQIAEEGSDDVQDKLMALRKLYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX40</accession>
    <name>A0A8B7ZX40_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nuclear pore complex protein Nup88-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110989527</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109667.1">
        <property type="nucleotide sequence ID" value="XM_022253975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX40"/>
    <dbReference type="GeneID" id="110989527"/>
    <dbReference type="KEGG" id="aplc:110989527"/>
    <dbReference type="CTD" id="4927"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019321">
        <property type="entry name" value="Nucleoporin_Nup88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10168">
        <property type="entry name" value="Nup88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="648"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022109667.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="82961" checksum="4F8B6D77A407BD46" modified="2022-01-19" version="1">MAAFPDEDLRLELWRKSLNAHPVFESLRSYDKHEPQRTEPENLLVVQEGQLFAWDSGESRLLTMNLKDLLDYIHADDVHSCNRRLQEVQAFQKLLCTNTPRFDIEHIELSTTGRHVLLWGTKGASVMTLPRRHGQFGQFEGGKEQINCRTVILAERFFMSSGTLRLLQAAWYPGSDSDIHVVLLTSDNTLRVYDVTSPHKPIQCHRLGEYSTSYSLSANRSTFEVALGDIAVAFDFGPVMEEPTKIERRSNAPPPLLYPVYILKGNGDVFLLKTSLSEPRYRYVHTNLQGPLTMHPPAEDNYGLDACSILCLHTSPIVLVVATSGGILHHCIVLTGDDEDDNDNHSVTSASISDIGSVRGKSDFALYVYESVELSLTVLSKDYPEDTAYPILLHKDPSSPCQYYCSHSAGVHCVTLSWLQKLTHYCSSEYEGNEEGSVMDVVNQDESCTVAHMICTKPSESCPPAPILGLTVVADHLLGQALLCRTSTNDCIVTPLKNDEMPPPPPLLSEEDTHESESSLKQLSSEPFQNRIRKILLRNVSNPILKGSSKTSLSPEESFDLVCSATKVLREEYISKQDLARDDIEKRVKILQQQKELQKTDLQDCNRLKEEIHNQAQQIAFRHDDALEKQQDLLERVGAALHALQGQLPVLSEAEQNLQKEMTDMEQKVEQLKDSLKKVKLKDEYRRKKMQELDKKEQSPSLSQGQNRHLKTLLKEESDTIASLVKEIKNLTVAVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXL9</accession>
    <name>A0A8B7ZXL9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Cytoplasmic dynein 1 intermediate chain 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12" type="primary">LOC110988786</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein intermediate chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108301.1">
        <property type="nucleotide sequence ID" value="XM_022252609.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108302.1">
        <property type="nucleotide sequence ID" value="XM_022252610.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108303.1">
        <property type="nucleotide sequence ID" value="XM_022252611.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108304.1">
        <property type="nucleotide sequence ID" value="XM_022252612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXL9"/>
    <dbReference type="GeneID" id="110988786"/>
    <dbReference type="KEGG" id="aplc:110988786"/>
    <dbReference type="OMA" id="ITPDIQH"/>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000781">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025956">
        <property type="entry name" value="DYNC1I1/DYNC1I2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11540">
        <property type="entry name" value="Dynein_IC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="17"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022108301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022108302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022108303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022108304.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="68345" checksum="96B502E89B18CE53" modified="2022-01-19" version="1">MSDRKAELERKKLRLQQIREEKKRKEEEKKKKEASDATKAVADAAGAGDKNLERKRQDADALLQELGLPQSIGSPPSPSKSSASDGGSQDSSTPDTVPYVVSASPRHKIKLGRSKPTIMGFPPKEIVTYAKETQTPTETQDKEDRSDAEDDEEDMPVTPAPAVVTPVPEAPLIEEEKEEEQKVQELTEEEVDQILASEEFLNFFNHSSKVVERALTEDKNIFIDYRGKGDEDGEGDKDAGAKLSLNYQFFDERWSRHRTVTSLDWSTQFPELVVGSYNNNEESPHEPDGVALVWNMKFKEASPEFIFHFQSAVMSAAFARFHPNLVIGGTYSGQIVLWDNRSTKRTPVQRSPLSAAAHTHPVYCVNVVGTQNAHNLISVSTDGKMCSWSLDMLSQPQDSMELHYKQSKSVAVTSMTFPSNDVNNFVVGSEDGSVYTACRHGSKAGINEAFEAHQGPVTGIDCHHVQGQLDFSHLFLSSSFDWTIKLWSLKQSKPLYSFEDNSDYVYDVQWSPIHPGLFAAVDGMGKLDLWNLNNETEVPTVSVTLDGQPAANRVRWSHNGQQIAAGDTEGRVFIYDVGENLAMPRHDEWSRFVRTLADIKAVTADTEDDDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXU2</accession>
    <name>A0A8B7ZXU2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450 2B2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110989862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110234.1">
        <property type="nucleotide sequence ID" value="XM_022254542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXU2"/>
    <dbReference type="GeneID" id="110989862"/>
    <dbReference type="KEGG" id="aplc:110989862"/>
    <dbReference type="OMA" id="EQCKEMH"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022110234.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42659" checksum="2EB85CBE3C7C62A0" modified="2022-01-19" version="1">MALMQKIIFCGVTTASGQMWRTQRNLVLRFMRNFSIGKAGFEGSISQEVLALIRELKKFREKPVKTAHLFHSAISNIICLVVYGTRYDYDDPKFKERLKLINRTFELLGSGSIFFMPFTDLVAGIIPSLWELTPKLYKIHQLCQGSPPLASGRLRSPERPNRFPLPVREIDAIVGRDHLPQMSDKPHLHFTEATILEVQRISNVVPLGVPHQAREDATVMGYTIPRGTILLPNFWALGHDPKVWPEPHLFKPEGFLDKDGQVTKKDEFTQFSVGRRMCLGEPFAKMELFLFFSGLLHQFTFQRPQGAPPISFKSRAGFTLTPISFEVCAIVRAQRGDSAFNRLFTDSEVHLLDQLIPGLKLIFKRLTYSVVVKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZ22</accession>
    <name>A0A8B7ZZ22_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110990207</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110990207</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110771.1">
        <property type="nucleotide sequence ID" value="XM_022255079.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110772.1">
        <property type="nucleotide sequence ID" value="XM_022255080.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110773.1">
        <property type="nucleotide sequence ID" value="XM_022255081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZ22"/>
    <dbReference type="GeneID" id="110990207"/>
    <dbReference type="KEGG" id="aplc:110990207"/>
    <dbReference type="OrthoDB" id="5952652at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022110771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022110773.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="51374" checksum="2DB5E9F1B8778925" modified="2022-01-19" version="1">MTKRRFLLNSTVVYVGLTILVLVFIAVSDYSGWSLRYVRPPLSLVGASALRHRLTDTVDRGRGADFNLTFTQGHTLTLTLRMEVKPTLVKVFFCDALRSAALFWSPKLGPISVILNEESAADHQFAGRMRRLEGELGFQFDFHYEPLPNDPSILKSFRGQGYARQLWSSFFMDMYIKASIVAWTDADGMFTAPVTPHNIFNGQRLRVVTFTDWKEIREYAWEITTETAMGKTLVSNFMSYFPVYIWRDTITNCRNHVVKHMQVSSFEDAFRKLVDAPVGKKGIPLSPVNVILNYAYYFEHDRYDWHLDGIRKDAPLGLAIIPSERVPEVRVTNHKASANILVQGYCIAKRYTDSLPAACERFRYIPNFHLFVFDVNTDHFNTWCSLRKGRRDCAKRIEAHYQNFRKHYSAGYDLDLQRVHRVEKAARREKVSCDEAFQFELNEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZJ8</accession>
    <name>A0A8B7ZZJ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic cation transporter protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110990273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022110859.1">
        <property type="nucleotide sequence ID" value="XM_022255167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZJ8"/>
    <dbReference type="GeneID" id="110990273"/>
    <dbReference type="KEGG" id="aplc:110990273"/>
    <dbReference type="OMA" id="CIFALQY"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MFS_dom"/>
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    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
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        <property type="entry name" value="Proteasome_assmbl_chp_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAC1"/>
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    </dbReference>
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        <property type="entry name" value="Sugar_tr"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="582"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="114"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="673"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022110859.1"/>
        </source>
    </evidence>
    <sequence length="673" mass="73564" checksum="4A512709428D0138" modified="2022-01-19" version="1">MADEKEKEAAAVAEEQEQPKEFDDVLGAIGEFGRWQQILFVLASLIGIMTSMNNLAQVFLAGEADHWCRVAPWDQANCTDTGPPDDWECLLEKRNASIPLVTNNNSDKAYDQCEMYDIGEKPFIPGANSSFYETSNTIKCADADGWVYDTRQYQTTIITEFDLVCDGTSLVSLAQSIYFAGLLVGSFVFGSLADLLGRKPSIYIATTLFLAATLGNVFSPSIVVYMVLRFFVAAGGIGAYLMSFVLVTEFVGPSRRVLVGISVQFFFAIGLTVLPLLAFLIRTWRFLQLCISLPTVLYLLLYFYMPESARWQMSKGKYKPAENTLRKIAATNKKDFPEKMFSPESIAASMEKSSSGQQTAVGLFRTPNMRIKTLNLMFNWFVNSLVYYGLGLSTSNLGVDDYLASALAALIEFPSLIFCIFALQYFGRRISLSSTMVIGGIACVITAFLEMGVARTVIAMIGKFCIAGSFAIIFVVSGEIFPTPVRSAGMGLSSVTARMAGILSPFMLDLEDLWAPLPFVLFGSLSIAAGLLALLLPETRNTKLPETLEEGEAFGKSYSEIALSDKRQAIASVSLELVPARILLLPTGLLLPCALCIIAINYVMWSSIFCDIDTASLEVVVLDTAPTAEYKTHMSPSDVSAPFLRSLRSRAHTSKMQCPVLESPNAIKGLCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1P7</accession>
    <name>A0A8B8A1P7_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990894</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="primary">LOC110990894</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
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            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
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            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111668.1">
        <property type="nucleotide sequence ID" value="XM_022255976.1"/>
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    <dbReference type="GeneID" id="110990894"/>
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    </dbReference>
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        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111668.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13797" checksum="C00421B4A2960636" modified="2022-01-19" version="1">MHKGGFPVEQNNCPTKWLPRKAFVGSALSGCTLVDAVPHFPTLFAPNLRVCALVTGFAPSEAELSLAPGARVERIASSHHTYSKPKFEKHYNFKMAAAMPESMDMMESVDATESAECSTAPAGXQSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A285</accession>
    <name>A0A8B8A285_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Protein FAM172A-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="4 5" type="primary">LOC110989703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_022254279.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21357:SF4">
        <property type="entry name" value="FAM172 FAMILY PROTEIN HOMOLOG CG10038"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    </dbReference>
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        <location>
            <begin position="190"/>
            <end position="436"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="183"/>
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            <begin position="487"/>
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        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
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    </feature>
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            <begin position="87"/>
            <end position="102"/>
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    </feature>
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        <location>
            <begin position="123"/>
            <end position="136"/>
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    </feature>
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            <begin position="161"/>
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    </feature>
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            <begin position="519"/>
            <end position="537"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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            <dbReference type="Pfam" id="PF22749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109971.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109972.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="60972" checksum="AF3D88B1D515AB34" modified="2022-01-19" version="1">MEESSQQSLMEAESQQIPVDSQQIPADSQQIPADSQQIPADSQQIPADSQQIPADSQQIPADSQQIPADSQQISSDSQMSVEQDFPESQSQMEMSQQSQAEESQPDRTTTVPKLPKLHRGSDADAATDSSASAATARAEQPEEPDDDVHQNGEGRGPGDTCTKEETEKLAESEAPTEGDERKIEEQWHVFPDTLEGFKYFFNDYGQLRHTDTGEPFVFEVRKGDMQYNQRHYEALGEVITEHVYGLLESEANLKRVYLGDAESEPRGFVFMSENARTTTDKLLILIHGSGVVRAGQWARRLIINDCLDSGTQLPYIRRAMQKGYEVLLMNTNENFATLSDGRRVSIKGSSSPREHGLNVWDSFVADTPAKHVAIVAHSYGGVVTIDLAAHRTESFRRKVFAVAFTDSVHSLHYGIDDDLFNWFTKNTVNWVSSREEVGTVIDDRGYDCPRVSAGTLRHEETSWYSYDSIFEFLSSKEQELKNFVGESSVARDASDAAGEDARKSEDTPGREDGDIEDTLGSQETEPQQAQHQENGGQETEIGGRETEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A467</accession>
    <name>A0A8B8A467_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Netrin receptor DCC-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="primary">LOC110990953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
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            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
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            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111715.1">
        <property type="nucleotide sequence ID" value="XM_022256023.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391">
        <property type="entry name" value="INACTIVE TYROSINE-PROTEIN KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391:SF18">
        <property type="entry name" value="PROTEIN KINASE RECEPTOR TIE-1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="138"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022111715.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="42879" checksum="9FB89D73A3886D14" modified="2022-01-19" version="1">CNEGTFGADCQQTCHCVSGGTCSKDTGECSMGCEASYFGTNCQCSIQNGVLGLEVTSGDPHQLFVTWQPDPCVSGYELTTRDECEDIVYQEMTLENAYHFITGLESPLSHRVYMRPVYPGNERGPEVTFPQITKPTMAPVDVNFTSATPYSLSVSWSKPPCGSRGGIITGYTYKLTEVSPESQAVIQSVTSDESVTIEGLTPLTEYSFQVAANTTVGAGPYSQASNKTTSKAPAVDDTPVPDSSSAVAGAVVATIVILILLVIVPIVLYKRRTRQTKQPLDIDGDVPLKGRDAHFLPDQKPENPPSAYATVNPVEIYPEPPPTPKPKPDLKPRWVSTNSPKETLEQPVVDEDEEELPYAELPSVREENLAEYIRSKDKAGKKGFPTDFQKRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A4L6</accession>
    <name>A0A8B8A4L6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAM and LDL-receptor class A domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110871.1">
        <property type="nucleotide sequence ID" value="XM_022255179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A4L6"/>
    <dbReference type="GeneID" id="110990279"/>
    <dbReference type="KEGG" id="aplc:110990279"/>
    <dbReference type="OMA" id="CRGHCTF"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="102"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="230"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="399"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022110871.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="65448" checksum="211C41E7BB75223E" modified="2022-01-19" version="1">MRIPFGGSCPAGSVSFVTFCTLPPDASWKQIFVSPLRESVLPSASLTFNFVMVRRGRTLIHLFVLCPAILPALNLLHDLLGRLPPDLNLDFKFDLCWILIPHARSLSGFYIYTKAAAQDSGEQARLDAVKATAPPTGACVRFWYHMHGSRMGKLTVYTGDEKGGLGPSRWSKKGDSGDYWQEASINIYPGSEFQITFVGECRASYGNDIAIDDIVVLERQCSSYASFSDLKCDFDSKSFCAYNNSQNDDFDWILNRGSTYTGVSGPDVDHSKGDSTGFYIYIKAMLQNPGDQARLDAVKATAPATGACVKFWYHMYGSGMGTLMVYTGDGKGGLGPSRWSKSGDSGNVWHEASINIGYGLDFQISFVGECGRNAGSEIAVDDIIVLEGQCNNKATFSDLECNFDFNAFCAYKNHPYNEFDWHLHSGPISGPDTGPEADRTTGDPSGFFIYSKVSRYMQGDQARLDGVKATAPATGACVRFWYYMYGGDEGTLTVYTGDGSGGLGPSRWSRKGDSGDYWHEAWINIYPGSDFQITFVGEGSWGYSCDVAIDDIIVLERECDSTVPLSDLNCDFEPGTFCAYKNSQNDDFDWILNSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A4Z0</accession>
    <name>A0A8B8A4Z0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Asialoglycoprotein receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110991106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111970.1">
        <property type="nucleotide sequence ID" value="XM_022256278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A4Z0"/>
    <dbReference type="GeneID" id="110991106"/>
    <dbReference type="KEGG" id="aplc:110991106"/>
    <dbReference type="OMA" id="ANFICEM"/>
    <dbReference type="OrthoDB" id="2142683at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="35"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022111970.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19808" checksum="6FF0AB5A0FBA9086" modified="2022-01-19" version="1">MAVTEHRNLKSAIIIVTTGFIVGNCAICTLGWLKHGSSCYKFASDKMTWENGSTYCQDLGGMLLVIESEEENDFITGKLRNLNMIRAWLGCSDKDSEGTWMCYADEGITRMQYENWADEKPNNFRGQDCGVIEKNKDGKWKDRGCNILRSTICEKSSRVSTMSCYSLDSDGRFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIJ7</accession>
    <name>A0A8B7XIJ7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Guanylate cyclase</fullName>
            <ecNumber evidence="2 14">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110973811</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 14"/>
    <dbReference type="RefSeq" id="XP_022080624.1">
        <property type="nucleotide sequence ID" value="XM_022224932.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973811"/>
    <dbReference type="KEGG" id="aplc:110973811"/>
    <dbReference type="OMA" id="PCRSVRD"/>
    <dbReference type="OrthoDB" id="10051822at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF501">
        <property type="entry name" value="GUANYLATE CYCLASE 32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="523"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="918"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1156"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1156"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1177"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1207"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1264"/>
            <end position="1273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022080624.1"/>
        </source>
    </evidence>
    <sequence length="1401" mass="155424" checksum="C3B31CF9F68002A0" modified="2022-01-19" version="1">MVFTHEVLNTMPVFPTGPRRLYVPCFVLYVVVMSQFPTVRAFEVTIGILGPWDAPGSYVYPLLGWRTAGAVPLALEHVRNEGILGNNTLNFEYRDTKCDTRRASGSAVDLHLFNGVHAFIGLPCSEPCRSVRDLAAYWNIPFISWFCPHTPATEAGDTYESFARTFVPFSAISSLPGAVMAQYGWTSASVVYADISPWNSLAETILATMINTGVTISNLQSYKEPLDVHNAATILQKVKNVSHVIWLIMGGVTTLEVDEQIFMLAADQLGMTQGQQVFLRLELFPDIGHTTPWLPLLVSTNSTRDNAGASEYALRQAYEALILITYRLPQDGRIEELLRLLPETLTDPSLDFYEKINTSTPSIMSAFLYDAVLLFAYAAKQHVETNDYLAANYTRTNVTFEGMTGYVVLDNAGDRIANFSVLDLKEGQRFEAVGHVSGIVPVFEEVPGADVWWPGTVIPTEPKCGYQGQKCLESSIIIAIVAGGLITIMLAIAVPYLSLKYRKYILRKDWLIEIDELTFLPLQNSTFGVGLQGYPSTYRLPNISERLLSRQSLASETVQENLRKQSQKMAPDLSLAKYKSETVVLRRAKVSNGLTLNKATKKELKEMRWLVHDNLNRFVGVCFPTRGDNNLFYYISEYCSKGNLKNVLANDDIKLDLSFKVSFINDLARGMQFLHNSVVRSHGLLCSNLCFIDSRWALKIAGFGTVSFHMSRGTGEKISDPEVRFSKLLWTSPELLRHELPTKGSQKGDVYSFGILVEEILTRSLPYHDYGLSSREIVRKVMTRQEPPFRPRQAASEDDLTGLSTQFSQSDGVLTCLTELMMQCWAEHPEDRPDFNVIRHRLRAVQKGRKELNLMDNMVSKMEKYTENLEKVVADRTGQLLEEKKKTDALLYRMLPQAVADELKKGQSFHGEFYDQVTLYFSDIVGFTELSAMSAPMEVVDLLNDLYTCFDAILERFDVYKVETIGDAYMVASGLPNRNGNRHASEIASMALAVREGVKTFRVRHMPEHQVQIRIGINSGPVAAGVVGLTMPRFCLFGDTVNTASRMESHGLPQRIHVSWSTAALLTSIGGYRLEVRGQLRVKGKGVMTTFWLLGTDEQSSTLQLQDALQNSSVKKISTDTVISEDSLLSPPNNTDPQDFINDSLIATRVLQEIPSGFGSEGSSPSSSPRRCRKGNSNSSRSVSQLSKHVTMIESPQTPTKIKHSNAGKTQGSNNIKSKSGHIMAKTGDAKAKTSGSTNRTDHTSTSDGFPSGAADPSTESGTEDLKLEDNRSSKNGVLITKPNDIVSTSADLVVEEGCFVRTESGDIVQTPNGDIVRKPSRQQQHHLHLGSLQEDPDSLPNVPSMPDVTVQSKEPETETKCHDSIFSYTIPLPQLMNEISSTLIDSSVNAVESNQQNTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIL2</accession>
    <name>A0A8B7XIL2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Keratin, type I cytoskeletal 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079775.1">
        <property type="nucleotide sequence ID" value="XM_022224083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIL2"/>
    <dbReference type="GeneID" id="110973348"/>
    <dbReference type="KEGG" id="aplc:110973348"/>
    <dbReference type="OMA" id="IASECCN"/>
    <dbReference type="OrthoDB" id="10060321at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762">
        <property type="entry name" value="ZINC FINGER RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45762:SF3">
        <property type="entry name" value="ZINC-FINGER PROTEIN AT 72D, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U1-type" evidence="2">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="U1-type" evidence="2">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079775.1"/>
        </source>
    </evidence>
    <sequence length="847" mass="87300" checksum="8A299863F26B30E0" modified="2022-01-19" version="1">MFQHQGSNFMMDPPSSFGGMGGGGGSFNGMGGGGGNFGGGNFSGDVGFLSGQNPPLPSGNNGMEGNDFFGGGGSLGFGGGMNRGGGMNAGGFGGGGARGGLRGGGARGGGGARGGGPGRGGGGFGQSGSSGRFGGGASGRGNGGGMRGGAGRGMGASRGALGGHGASQGPPRGGASRGGASGGGSMKLDTPSESGYLQDHKGHFPDEYWCKLCNAKTTGPNNYQAHLNGVRHKQNVLNLQNGEPPVKVGPLAQRKRKREMENTEKKVLSEMLPQNKEPVVGLEFVTEIIREGSDSDPDYECELCDCRTLQGNIIYHLIGYRHRMAYVKLKKPDVAEMLDNLANVEEDAPKEEDGTKKMTPEEEEASKKRATRNKISEKLKQIIPKIASECCNMTHKVKRVKAENLGVPVPKKPVPTASAKNYTQNLQSGAGGRGGGAGSRGGSFGGRGGAAGGFGSATGGRSGSGRGRGGGAGGHGFPVELGGFGDLGGIGGPIGDDIGQFGGGSGLDSGGLGRGFGQGAPPRSGAGFGSGLGRGPDMDEGFGDPLGPRGRGRSFDPYEDTADLGGGYDLPPPSRREEIETIKSEILDSLTRDSVVSDAFILREFERRFGSTKRQPRSDVYDDHDRDRDRDLLPPPIHEPLSYRDKIPETIEQGGIKRLESRQDNHSNNQNVTSFGGGNNYSAQPGSSSSMYPMTYDPMPRSTFNTESKITVSLEELGRLNPTPKPSSGLKSCLKKPPTSTTSVSSSASTSTGYTTSSKPTTAPSGGAAVQEMFANLSQSMITNEADAHLAKQVTETLSQALQMYESKLTGDRPDPTGSYGEPLRGRSLLPPPPPGPFGSGPGYSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKF7</accession>
    <name>A0A8B7XKF7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Transient receptor potential cation channel subfamily V member 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110973818</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080632.1">
        <property type="nucleotide sequence ID" value="XM_022224940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKF7"/>
    <dbReference type="GeneID" id="110973818"/>
    <dbReference type="KEGG" id="aplc:110973818"/>
    <dbReference type="OMA" id="CDEYYGE"/>
    <dbReference type="OrthoDB" id="533508at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF28">
        <property type="entry name" value="NANCHUNG, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="582"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="15">
        <location>
            <begin position="469"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022080632.1"/>
        </source>
    </evidence>
    <sequence length="755" mass="86618" checksum="E44D176C8B64D76B" modified="2022-01-19" version="1">MKEDVKYGNDSQTNVCMEIYELYEDLVDLAREASKSRVSQAAFEDKIRGSDVSKFLYDDGSGKMTSIKALVKIRNQDNWINNDVVDARDQKKKRRPIAKLKKTMVTGSSLGSANKIKSEQEAQREVCWDIDRRGYSGETLLHVCFMSPHNKDVNFEIAKQLIKAWPKMINDFILGTENYGETCLHKAIVNENISMIKFLIENGADLNVHCYGRFFRPDDQKAWCEDSLNHEHFILYKKTNYEGLTYWGETPLTFAACLDLDHIFRSLWVKGCDINAQDTNGNTVLHMMVLHDKKDMFTLAYELGGDCTIKNNQGYTPLSLAAKLHRIDLFEHILFLERQLSWKYGDVTCASYALDGLDSINYDGTINNKSSLHLIVNQTSKEHLQMLKGVIYKLLDEKWKTFGRFNFFARLAFFLLYLAVLTTAFYLRPGKDPKAFTVHNNVTLPNGSVIDAGTEVIEPCYLLYTDTSTDQARVVFEIITLIGSLSYLFFAAKETYHLGKWSFMELMVLAPAKAMFLLSCCFIILACFGRIPPCNPYYEDVFITFAILTACPYSLFFLRALKLVGPFIFMIYKMIHGDLLKFLAIYLIFLFGFSQAMHIVFLGYRGEFELLDSVIGMFVMSLGEFGDIYATFDETRYPVMGKLLFCVYMVLVALLLVNMLIAMMGSTFSTIAETENEWQRQWAKIVLILEQSLSPAVRVSVLHKYSTPMWDGRQDRAMIMQTENEDHDDATIQKSKHRHNVNSNREFIDGVWQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKI7</accession>
    <name>A0A8B7XKI7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Prickle-like protein 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110974185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prickle / espinas / testin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081319.1">
        <property type="nucleotide sequence ID" value="XM_022225627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKI7"/>
    <dbReference type="GeneID" id="110974185"/>
    <dbReference type="KEGG" id="aplc:110974185"/>
    <dbReference type="OrthoDB" id="10069167at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09415">
        <property type="entry name" value="LIM1_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09418">
        <property type="entry name" value="LIM2_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09420">
        <property type="entry name" value="LIM3_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09827">
        <property type="entry name" value="PET_Prickle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000035">
        <property type="entry name" value="prickle-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000005">
        <property type="entry name" value="Testin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033725">
        <property type="entry name" value="LIM1_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033726">
        <property type="entry name" value="LIM2_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033727">
        <property type="entry name" value="LIM3_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010442">
        <property type="entry name" value="PET_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033723">
        <property type="entry name" value="PET_prickle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047120">
        <property type="entry name" value="Pk/Esn/Tes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24211:SF20">
        <property type="entry name" value="PROTEIN ESPINAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06297">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51303">
        <property type="entry name" value="PET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PET" evidence="9">
        <location>
            <begin position="76"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="186"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="251"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="603"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022081319.1"/>
        </source>
    </evidence>
    <sequence length="678" mass="77169" checksum="48F9BC7E224C6CB5" modified="2022-01-19" version="1">MLLRTGSGGRKKDKKDLHGPGYDTDKGRPCMKCGDRCPGLALHYWRKICLHCKCPREDHYIMSGDQEKTVSRMMTDFHQRNSTSDDDSGCILEEYTWVPPGLKPEQVHQYMNALPDDKIPYVNSEGEKYRIKSLMQQLPPHDNEVRYCNGLSEEEKRELKLFSAQRKREALGRGTARPLPLTLAGCVCYECGNAVCGGDIAIFASRAGPNACWHPACFICTVCKEQLVDLIYFYREGKIYCGRHNAETMKPRCAACDEIIFADECTEAEGRSWHMKHFCCFECDKELGGERYIMREGKPYCCTCFETMFAEYCDTCGEPIGVDQGQMSHEGQHWHATQKCFQCCTCGVSLLGRPFLPKHGLIYCSGSCSRGEKAVTAGPLTSPQEMDDPMGLGSPKMSRSRRPINMEELNLDNLSVATAEERTQQSIHRSRNLSRHSLPDLRRQSQTSAEDRRRASVRTASERRRNSTAAAQSRAYKEEAVQGRYKAAPSTDQMQRRATSDVRTATNTIGGSQRTQSTHSINEERFVTPRSDSSYRHGLVPKTNANYHNGMRRPETMGHYSTQPRNPRDPEYFDRKSNVYHSERVTGRSRSEITLDQRAAMDRYSSGRRRGYRDDYFSSSSSSEDEDYFSPSHKAQLGPRIRYVETYARTRSQSQPFNQKQSGHRKKSKQRGKNCIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM73</accession>
    <name>A0A8B7XM73_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110974158</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022081262.1">
        <property type="nucleotide sequence ID" value="XM_022225570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM73"/>
    <dbReference type="GeneID" id="110974158"/>
    <dbReference type="KEGG" id="aplc:110974158"/>
    <dbReference type="CTD" id="93587"/>
    <dbReference type="OMA" id="FKKNDGW"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18101">
        <property type="entry name" value="Trm10euk_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000001">
        <property type="entry name" value="tRNA methyltransferase 10 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016653">
        <property type="entry name" value="TRM10/TRM10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016323">
        <property type="entry name" value="tRNA_m1G_mtfrase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="9">
        <location>
            <begin position="91"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016323-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016323-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022081262.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35952" checksum="99804D836BCB2CBD" modified="2022-01-19" version="1">MDDTKGIKSDVADAAMSANQDERDGTQEEVSTTSGTVPVSKNQMKKMMKNAEWRERRTAKRLKEREKRKLKKIQEREGMPEALDDGQVRIKRRRMNDPEASEIRVAIDCTYDHLMNDLEIKKLCKQVQRCYAENRSLTNKPLQLYICGLVGRFQQISDQVITGYKSWDVHWKTDGPEAAFGRDNIVYLTSESPNLLTELQTDKVYVIGGLVDHNHYKGHCFALAQENGWSHAQLPISDYIMLRDRKVLAINHVYEILLAFIKTKDWKEAFLKVLPQRKVAAVKESAEVKGGSSHGAKNPDKVDLAADEATDKDSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMT3</accession>
    <name>A0A8B7XMT3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine protease 23-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110974638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082133.1">
        <property type="nucleotide sequence ID" value="XM_022226441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMT3"/>
    <dbReference type="GeneID" id="110974638"/>
    <dbReference type="KEGG" id="aplc:110974638"/>
    <dbReference type="OMA" id="FYRFCTV"/>
    <dbReference type="OrthoDB" id="10037376at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050966">
        <property type="entry name" value="Glutamyl_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15462:SF8">
        <property type="entry name" value="SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="3">
        <location>
            <begin position="183"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022082133.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46771" checksum="CBD3C48E48D03FF4" modified="2022-01-19" version="1">MICENLNYNSGMMVYINVLFITILASALVSCCHGKPSLHLAVEKWHRFQLPTAQGTSPLRVESTVLEEEKEEWKADVEDDDGGESDRIILYCGEECEEPDEYRNYTIKEAEDTLAFETVYPNGTRTLTRLQVPEQMVEYINGWMRGVKRHTGKAEAVDAKVRRKRAVFDFDTRFEVNVAKYLTEYPFSAAVKLSTGCTGVLVSSQHVLTAAHCLHNGKRYIVKVKDIKAGFRREATPGEDPSEAYERSFIWIRADKVYLPYDWTNKRNSLQPLDKDYAVIVLKRSPDREHLEVGMGDTGNVPVGTMVHFSSFDIANQPKLFYRFCTVTGGTQELFYQQCDAEPPSIGAGVYIKIWDPEAGSWSRRVVGLFGGLTSFINALGIREEQNVAMRITPLKFAQICFWLTGDYGECKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR75</accession>
    <name>A0A8B7XR75_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras association domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110974877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022082495.1">
        <property type="nucleotide sequence ID" value="XM_022226803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR75"/>
    <dbReference type="GeneID" id="110974877"/>
    <dbReference type="KEGG" id="aplc:110974877"/>
    <dbReference type="OMA" id="ELMWRIE"/>
    <dbReference type="OrthoDB" id="74314at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20885">
        <property type="entry name" value="C1_RASSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01778">
        <property type="entry name" value="RA_RASSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21892">
        <property type="entry name" value="SARAH_RASSF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033614">
        <property type="entry name" value="RASSF1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738:SF10">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22738">
        <property type="entry name" value="RASSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16517">
        <property type="entry name" value="Nore1-SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="7">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="392"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="9">
        <location>
            <begin position="483"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022082495.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="59524" checksum="DF6A64831D531392" modified="2022-01-19" version="1">MRAADIDGTEEATSSLNSAGGRRHSHPDTTTINSNNSNTANEHSSSGLLASLWTKMSEYVELRTLESHPSVSSTDSGRFSGSELFDSGESVNGSAVDRQSVHSAERPVQQRNGHPKEHSQRNSIWNYFFGGGGSSSDSKQSSSASKSKPPSRKNSSSSQDAGHRPRSASYSSPPPPPPSSTNFTRVKESIPTAAETEFAANGTNTWLEWNPLDEDDSDSSDSSSLVASEEEQLHQGTGEGHDFVPVYLNFTWCDQCGGVIWGFRQCLRCTYCKYTCHYKCLNEVRLDCTESPVFKEAQSESPQHTIVAIENGVEDTSSLTGLSREELMWRIEEFNRKADMYPIKLESDSLIFVGSIRIYMNLSRPISIPSGSPLPKACSTLRPYDHSVDHSKRRTSFFLPKNTYEDIQIASESTAIQVIQGVLSHIEVIDNCRKFALFERSDENGEVLMRKLADEEKPLLLRLLWGGDSTTKRYELRENETGQIEWEAFTVPELQNFLRILDKEEQDHIQQVQNKYVVYEKRLRDALNYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR85</accession>
    <name>A0A8B7XR85_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">THO complex subunit 7 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110974879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082501.1">
        <property type="nucleotide sequence ID" value="XM_022226809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR85"/>
    <dbReference type="GeneID" id="110974879"/>
    <dbReference type="KEGG" id="aplc:110974879"/>
    <dbReference type="OMA" id="WANSKND"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF5">
        <property type="entry name" value="THO COMPLEX SUBUNIT 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022082501.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="24202" checksum="521DE63299EB2769" modified="2022-01-19" version="1">MATDDEVIRRRLLIEGESGGDDRRINTLLRMFIKWCNSDTSEEESVATYQKMLSILAQVEFAMEKTQLIHDMNTKELTNYEELYSEIEQSIKEAHSKISACKLQVQDAKRVRKNRQEYDALAKVIKLQPDRRESMKKLEELDKELSNLKCSKQTLEQKLEDRRKQFHVLISSIQELQRILEEDDKGKEVHMETTLDRSMDTSMGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSJ5</accession>
    <name>A0A8B7XSJ5_ACAPL</name>
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        <submittedName>
            <fullName evidence="4">Transcription factor ETV6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083833.1">
        <property type="nucleotide sequence ID" value="XM_022228141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSJ5"/>
    <dbReference type="GeneID" id="110975560"/>
    <dbReference type="KEGG" id="aplc:110975560"/>
    <dbReference type="OrthoDB" id="10042983at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="2">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083833.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="17437" checksum="7589E7EE722DA86E" modified="2022-01-19" version="1">MSRVCSPADFCDSQPLVEPADDVKKVIDLTVPRPDIMQVEADTLRVASRDPRLWTRADVVSWLEWARGFYQLDSVDTTKFAMNGRGLCLLTRSGFMNRAPSCGDVLHSDFQRRYAVAVLRAEEVKKTKRRALWRPDATHGKDDSKKPKVEENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTG9</accession>
    <name>A0A8B7XTG9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975272</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083305.1">
        <property type="nucleotide sequence ID" value="XM_022227613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTG9"/>
    <dbReference type="GeneID" id="110975272"/>
    <dbReference type="KEGG" id="aplc:110975272"/>
    <dbReference type="OMA" id="MHGNLNE"/>
    <dbReference type="OrthoDB" id="18964at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017243">
        <property type="entry name" value="Bloc1s5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31784">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31784:SF2">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14942">
        <property type="entry name" value="Muted"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083305.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="18431" checksum="7FAA034B1BD1A579" modified="2022-01-19" version="1">MVENVIKDLGEIHARLLDHKPVIQGEIRFFIKEFEGKRNDREQKRLERIATQMKDLNEKIFPGCSSLMDKHCQEALEQLEVTNMMCRRLQKQEEDRLESKPLEKERAKREEDWKVFLERLNEQRDALDSEHQRKIDEIEAHYNKLKQTLNTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTU4</accession>
    <name>A0A8B7XTU4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">U11/U12 small nuclear ribonucleoprotein 48 kDa protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110975291</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083340.1">
        <property type="nucleotide sequence ID" value="XM_022227648.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083341.1">
        <property type="nucleotide sequence ID" value="XM_022227649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTU4"/>
    <dbReference type="GeneID" id="110975291"/>
    <dbReference type="KEGG" id="aplc:110975291"/>
    <dbReference type="CTD" id="154007"/>
    <dbReference type="OrthoDB" id="69229at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051591">
        <property type="entry name" value="UPF0224_FAM112_RNA_Proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402">
        <property type="entry name" value="GAMETOCYTE SPECIFIC FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21402:SF10">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 48 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022083340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083341.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="52055" checksum="FE5C1C765F039CA5" modified="2022-01-19" version="1">MTVTSSCSITVGKMDERHQKRQETVDQLTAFIDSSHHQLDELLSRLQWDKEDILISLVQQNQNEKKMKLCPINSHHLVPETCLEQHTLECELVAEGYSRQEQKEIPRSNSFFYERSSSVVPVFIDKEAQEDILSRVPGSSAGKDVPRTVDRMDKAFTSAEKLAIHVAVLEKSKASREKDTVSLQDLEFNQEAPLKTDESAKPKTRLEILAEMRDYKRRRQSYRAKNVHITRRSQTEIMREVIEAQMNELQQALQGDDRSVQNSEPRGRSSSPDKPRSRDASHSPLRSRPRPDDRWSQHPQDSRGRGTSNRSSYEDEADYHPVRHADARSRDRSRSPRPSSSRKDSHQDRHGRCHEISPSSLIKVEKIEGRKSHESSGSPRPSEPGTGGDSTSRSSTPLTMMVPYIKVERDTQAHSPSQGRGDEREKEDRRERHHSKHKHHHKHKKHHSRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV32</accession>
    <name>A0A8B7XV32_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110976064 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110976064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084718.1">
        <property type="nucleotide sequence ID" value="XM_022229026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XV32"/>
    <dbReference type="GeneID" id="110976064"/>
    <dbReference type="KEGG" id="aplc:110976064"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034925065" evidence="3">
        <location>
            <begin position="28"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="150"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022084718.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41209" checksum="7C14C81AD8944612" modified="2022-01-19" version="1">MAPAPVLEIFFSLVSIFLQIIVSSSETAQISIAPWNQSVMAGETATFICQINYYIDCPSQDRVYWVHRPIGGKDSDTQSLTGCSQVLSEANVDKYSAFVETSGNDTTYTLVINNVSPADSKEYNCFAFRGVEHESSSRGVLIVTNRAICPTPLNMSVNIIQKEDLVVGGVGEFYCDTNPQSGSSSFRWLKKDSGNQTVSINTTGRFVTSANRLIVSQLLASDNGSQVRCEMTHTTDCELPSPWYHLFLIPGTFDPTEQEPKDFSTVGATSKQVPSKGHDPHTLAGPSETHHPSEKPSETGEPTPAHRPGQTQPSRQSSPVGVIVIGIVATLFLITFTITFTCHMVKSRRSPIDREPAYEGATRTVASSLQMIEKELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVA6</accession>
    <name>A0A8B7XVA6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110975546</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022083811.1">
        <property type="nucleotide sequence ID" value="XM_022228119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVA6"/>
    <dbReference type="GeneID" id="110975546"/>
    <dbReference type="KEGG" id="aplc:110975546"/>
    <dbReference type="OMA" id="VAMRRFY"/>
    <dbReference type="OrthoDB" id="17569at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF79">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022083811.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15532" checksum="DEA9EB5AC65D3B40" modified="2022-01-19" version="1">MPVALNRFYEFVYEPPVKVAIYGPFLSSLTEVVAEVIGKWNIVEMSPSATTPVLSERERYPHIYRMITSAAGFSSAEFRMCRLFGWNKIATLHETTEPHVGTIHELQRLISTSNLSIIAAESFYKDPYEAMERLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXR4</accession>
    <name>A0A8B7XXR4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">KAT8 regulatory NSL complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NSL complex protein NSL2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Non-specific lethal 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110976588</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the NSL complex at least composed of KAT8/MOF, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085679.1">
        <property type="nucleotide sequence ID" value="XM_022229987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXR4"/>
    <dbReference type="GeneID" id="110976588"/>
    <dbReference type="KEGG" id="aplc:110976588"/>
    <dbReference type="CTD" id="54934"/>
    <dbReference type="OMA" id="DKRESLC"/>
    <dbReference type="OrthoDB" id="677315at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026316">
        <property type="entry name" value="NSL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025927">
        <property type="entry name" value="Znf_KANL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13453:SF1">
        <property type="entry name" value="KAT8 REGULATORY NSL COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13891">
        <property type="entry name" value="zf-C3HC3H_KANSL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="15">
        <location>
            <begin position="19"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="KANL2-like probable zinc-finger" evidence="15">
        <location>
            <begin position="296"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022085679.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50494" checksum="B6E7ED81097CE2E0" modified="2022-01-19" version="1">MHKSKTGHSRRHRSDGLFCNYAHRICMQDRLDGYEYCLNHILEDKNAPYKHCTFVSNKGGRRCLQPAHKADKRDGYCREHAQKVAVLRHKAGLKPFPRNSPREILDSLDRYQQEPGKMTPDALAEAQPSVAAKILDCASESESDEDPLQVDQAWRGTTDSDAESVDSEQEDLLKHAGVYTPEEVALITREKLIRLQSLYINQFKRLQHLMKEKRRHYLLALKQEKETIGMSLGSFASPKEKRKVLRLKSMQSYHRRHGREALLHKRSKHRRIKATPGYSGSQKVSLPARCKHTRENKPCERPALPITGFCLDHVLEDSHQVLYTPCTKGRVACTYPADPLSLEGTCLLHTPVAPECFRSANQQLEEESEQEKNASAAMADHDYLQRPSEATDASDHDVDILGLSGEQMYMLGTVSDEPDILSGQLPPTSLAENPKEPERTAVSQAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYC4</accession>
    <name>A0A8B7XYC4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Double-stranded RNA-specific editase 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110976367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085262.1">
        <property type="nucleotide sequence ID" value="XM_022229570.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085272.1">
        <property type="nucleotide sequence ID" value="XM_022229580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYC4"/>
    <dbReference type="GeneID" id="110976367"/>
    <dbReference type="KEGG" id="aplc:110976367"/>
    <dbReference type="OMA" id="QDPTEVK"/>
    <dbReference type="OrthoDB" id="10056847at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008251">
        <property type="term" value="F:tRNA-specific adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006382">
        <property type="term" value="P:adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19862">
        <property type="entry name" value="DSRM_PRKRA-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19864">
        <property type="entry name" value="DSRM_PRKRA-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910:SF62">
        <property type="entry name" value="AT07585P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10910">
        <property type="entry name" value="EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="90"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="214"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="305"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="A to I editase" evidence="5">
        <location>
            <begin position="453"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="721"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="721"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022085272.1"/>
        </source>
    </evidence>
    <sequence length="812" mass="89278" checksum="D2EBFBBAB1F05748" modified="2022-01-19" version="1">MANCKTAVSILQEHCARQGMTPIYNTISQEGLSHQPKFTINCTAGQTVGTGEGVSKKSAKQAAAEAVLQQWEVEIPKLDSVKAETVDPPNPVGQLQELVTFLGWRRPEYDEIEETGPPHDRSFVIGVTVGKFKEQGTDKSKRLAKRTAAKAMLEKIKALPPDTDPGIEPGTTKSKKKQAADAPAAKATGCSLQFAVGQNIDRLRNNPLNFPDAQSCQILQLIAVEQNFATRYIDLPEPGPNNQYQCLVELQTSPLAVCHGTGQRLDSAHATAARNALYYIKMMAQKPPDALIVPTDIKDEFEPPSHKNPVQMLNEMTVTPLDFSMVDKSGPPHEPVYVMSIQLDGQIFTAEGKKKKEAKEAIARKALLTVFGIKSPDNDGLLYARTRPTPSVLYSTWSAQKALICANLIQNLIEAKLREVTLNDGQHRYLKYKVLAGIVQSDGEAVESLKVVCLATGTKCPLAEEPHTKGTIIHDCHAEVIARRCLKRYLMEQLLEYQKNPRSSVFDGGISGILQLKEGIRFHLYISCPPCGDASSFIKEERNMGHNDVHPGRGARGILRAKIKQGESTIPLTGKATAAPERLFTMTCSDKVASWNVLGIQGALLSHLIAPVYLSSVVLGMQYHPDHLPRALYGRLTDLPDLPRGYKLNKPLMVGTSRPSQCPFGASPVAKAPNFSINWIIDLDNIEVIKTDKGLKEDGSSSRVSQEKLFSTYMVIMNKFPSSKGQTTGGSIKQSPQRGSSSKKDKQGKGNVSKEKPQQNFKVGNTYREVKEKAEAYQECKKILKATFLSEGLGRWLERPKECDNFSIVPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZH3</accession>
    <name>A0A8B7XZH3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Kelch-like protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8" type="primary">LOC110976906</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086299.1">
        <property type="nucleotide sequence ID" value="XM_022230607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086301.1">
        <property type="nucleotide sequence ID" value="XM_022230609.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086302.1">
        <property type="nucleotide sequence ID" value="XM_022230610.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086303.1">
        <property type="nucleotide sequence ID" value="XM_022230611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZH3"/>
    <dbReference type="GeneID" id="110976906"/>
    <dbReference type="KEGG" id="aplc:110976906"/>
    <dbReference type="OMA" id="HGIKALM"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18445">
        <property type="entry name" value="BACK_KLHL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF419">
        <property type="entry name" value="KELCH-LIKE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022086301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022086302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086303.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="65213" checksum="65E61E9FDFA31A17" modified="2022-01-19" version="1">MMDFDELEAGCNADFTLHRAHEHYSSQALRLMHQLRQARKLCDIRLRVGEQEILGHRVVLAAFSPYFYAMFTGDMLEASQSEVVMKEVDPRSLELLVEYAYTGILEIHIDTVQSLLDTAAMIQLGDVQTACSEFLKRQLHPANCLGIRNFADAHTCTDLVEASGKFAERHFTEVANEEEFLQLAKPQLAELLQCEDLNVRSEEEVYNAIMRWVYHDKEARRGEIADLLRAIRMPLLSPRFLVDTVEAEDLIKQDIKCRDLLDEAKNYHMLPDRRTRMQQERIRPRRSTVGSIYCIGGMDSTGHSLSSVERYNLSNGRVSIEASMNSPRSGVGVAVLDGKLYAIGGYDGSQYMNTVECLDPTTRRWHRVASMLHIRRYHSVVAHNRQLYAVGGYDSSTVLDSVETYDPRTNRWWRVGSLETKRRHIGVAALGDYLYAVGGSDGTSYLNSIEKYDPRLNQWIPVDSMHSRRGGVGVAALGGRLYAMGGYDGQSNLNTLERYYPEEDRWTFLAPMAQCRSGHGCVVVGDLMYAVGGHDGVQYLNTVEVFDTQLGEWHCQGPMGTCRAVAGLAVLSNIPCTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZL4</accession>
    <name>A0A8B7XZL4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Adenylate cyclase type 9</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">ATP pyrophosphate-lyase 9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Adenylate cyclase type IX</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Adenylyl cyclase 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28 29 30" type="primary">LOC110976938</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29 30" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 31">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="23">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022086349.1">
        <property type="nucleotide sequence ID" value="XM_022230657.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086350.1">
        <property type="nucleotide sequence ID" value="XM_022230658.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086351.1">
        <property type="nucleotide sequence ID" value="XM_022230659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZL4"/>
    <dbReference type="GeneID" id="110976938"/>
    <dbReference type="KEGG" id="aplc:110976938"/>
    <dbReference type="OMA" id="FTAMPPG"/>
    <dbReference type="OrthoDB" id="10035433at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000008">
        <property type="entry name" value="Adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000014">
        <property type="entry name" value="adenylate cyclase type 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45627:SF8">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 23" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="814"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="845"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="901"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="26">
        <location>
            <begin position="331"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="26">
        <location>
            <begin position="982"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="504"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00070496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022086349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022086350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_022086351.1"/>
        </source>
    </evidence>
    <sequence length="1200" mass="134307" checksum="A05827425FC5ED69" modified="2022-01-19" version="1">MAGNASDIEVHFNPNADEMPVEVTLRRRSSENSRTKGRSLCPKLFERASGSWWNPKFDSGIIEEQFQSNSFSQIRRRFRYALCYILAACVVWLIYLPVRNTVGRQTDHLCLKDQEDSGQQAWIAFELAVACLLVLCVILLIFTISHHYKSHFQKVSGVLCLCLCGLTLVTFVSHSSAGTSSPMSSVATFAMCIETILMMYTLIPMPYLYTLIPMLMFSVAYELLYFLYVDPESSEHSITGEVVNKLFLHVCVHLMGTHVFFMTQVRSRNTFMKIGQAVMARHQHQVEKQLKETTIHSLMPDSIAHKLLEEKGERSDKIFRPFYMDLMEDVSILFADIAGFTRMSANKSADVLVGLLNNLFGRFDILCLEHKCEKICTLGDCYYCVSGCPEPRPDHAECCVDMGLSMIEAIKDFCQETGEKVNMRVGVHTGKVLCGIIGNRRYKFDVWSNDVTMANKMEASGIPGKVHVSAQTAEFLGDKYIMEESRGDRQAVFLGGKTYFITGLKEDPSSKPAQMDTDVETSADNAKEPLSRAESKEDEAGEKGEVAGSEAGHGSSPNGNQSSKPLLGESKTDSRQNSPVWKRSSPGARKPKALEAPSHLQVPGDAKGENGGLGSSRTLSVRDLLADGNPLNIPLHNNTQSNSDQNFVDCIKQEGATDYFHKPPISNLTLTFHSKSIEALYRAQFRQDSSKEPRNPETSRKNRRHSSETISTAKYNTVFDVVVSFVVYLLISIGCFLVFQTQVHWLIIFPIAGALQLVVLSAVLLQAFSKWRSNFYMALSGFFHHWWPRHILGAILISLPILAVYANFLCQPDYNIYTKQFFCFLIVVALLHFCNFVQLSSWMKTILAFMYAVIMLVLFNLNPCDQRQLPTVPVANNSLNDSDGPAGYAEIPDMTGCTFEAMAMEVIIDIFLLLILVLFLNREFEISYRLNFYGGVEAGQDKEQMQIEKEEAETLLHEIIPTFVTEQMGSTSKFSQNHENVAVIFCSIVNFIDFYEEAYQDGKECIRVLHELVSDFDNLLSMEDFKSVEKIKTIGPTYMAACGLHPPSAEDDGNPTKCLINMMEFAIEMIKQVKVFNDEVLSITSGAFKFIPRIGYNHGQLTSGVIGTTKLLYDIWGDTVNVASRMDSTGLAGHIQVTEHTKKALEPYYIFEHRGPVKVRGKGDMTTYLFKGKRDSPLLIGECNSVAASPNGPSSPSKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0I4</accession>
    <name>A0A8B7Y0I4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110976770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086027.1">
        <property type="nucleotide sequence ID" value="XM_022230335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0I4"/>
    <dbReference type="GeneID" id="110976770"/>
    <dbReference type="KEGG" id="aplc:110976770"/>
    <dbReference type="OMA" id="ACFGRRI"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF15">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="15"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086027.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25901" checksum="990ED3530F5248A8" modified="2022-01-19" version="1">MVLNGVQYFQPVVSYVQGSKGVTWEGGVRVPSIAWWPGTIPADVTNHEVISSMDLFSLAVDLAGGSLPTDRIIDGRSIKEVLLHGGRSPHQALFHYCGKRIMAVRHGRYKMHYHTQEVLTDEALSALCRPRRVQNRMGTFHCGVCFGAYVTTHDPPLLFDLDEDPEEAYPLPVEEHAEIVYEVDHLVSEHQAGMAHGLPLFIDEYMGSPVIPCCNPPYCCCRAKYDSKNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0S0</accession>
    <name>A0A8B7Y0S0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110976816</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086117.1">
        <property type="nucleotide sequence ID" value="XM_022230425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0S0"/>
    <dbReference type="GeneID" id="110976816"/>
    <dbReference type="KEGG" id="aplc:110976816"/>
    <dbReference type="OMA" id="KYTLEYD"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086117.1"/>
        </source>
    </evidence>
    <sequence length="798" mass="91274" checksum="D61665023327F7E0" modified="2022-01-19" version="1">MATRFNRVFVFLVITLAVFLFACTTVWNIESNGGVIPGRKDALIILPPVRRSYEKSATSLNTIRLSTTWNGSQDVPASQQVANGTITLHAAAKSDQETIQTLGKQQRIVIIGSGPAGLGAARRLLDLIRKSNESVITILEEEGRPGGLASSVRDDQGFLWDAGLHVVFSHYTYFDHVVNMAVPEWNYRRRASFVFMKGSDANRRFIPYPVQNNIHTMDKGDQQRSLQGLEEVTKQPTSRKPTNFDEWLLQKFGAGLADIFMRKYNRKFWTVDTTEMNSAWVGERVAIPDIAEIKTKIEEVDNKTGAKDSEQGLIPFFRFPKYNGTGGLWESTARQLPSHWIRFREKVSGIDIDKKVITIDKGHNSKYTLEYDTLVSTTPLGIFTGLLKSSDLSLQQIQEQASRLVYTHIHVVGIGLSGQPPQTLADKSWVYFPDSDSPFYRVTMFSNFSDDHVPKSGKYWSLMCEITEPQKNLDSVVWNKENLIKASIRALVLYGFITDDIVVSKYYRRLEHGYPIPSLKRDMILETIQPWLKTKGIYSRGAFGGWKYEVASQDHSFMQGVEAVDNFLNGFPERIYPNPSLIDSTENKERKIPEDYVIVIAQYTESLDWVKPFAGHTFVYHKGGDLRPTRKWLSWESLPNIGRESHSYLHHIITNYDQLPRVTVFYPGAIADHKNCPQNPRVSISAAKRGIPCRGDSPFNVHRGHVIGGSYLKKPKNKYFRRSDFTFLEFYEYIYRRKPAHPVIKQCWKGCFAATKAMIKRHPLDFYIRAISTLGKSSNPEEGHYFERLWYHMFHDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0Y3</accession>
    <name>A0A8B7Y0Y3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protein piccolo-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110976559</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085626.1">
        <property type="nucleotide sequence ID" value="XM_022229934.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976559"/>
    <dbReference type="KEGG" id="aplc:110976559"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20538">
        <property type="entry name" value="CYCLIN_CCNT_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20539">
        <property type="entry name" value="CYCLIN_CCNT_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000004">
        <property type="entry name" value="Cyclin T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000009">
        <property type="entry name" value="cyclin-T2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="14">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="266"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="366"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="792"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1135"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="807"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="834"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="911"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="987"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1044"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1159"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1198"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1218"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1237"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1265"/>
            <end position="1281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022085626.1"/>
        </source>
    </evidence>
    <sequence length="1281" mass="142799" checksum="A9E92219B1E4A6AA" modified="2022-01-19" version="1">MAAIPDRERRWYFTRDVLLNSPSRKCQIEPRQELSYRQQAANLIQEMGRRLQVNQLCINTAIVYMHRFYVFRSFQRFPHNKIAAAALFLAAKVEEQPHKLEYVIKVHHACQHRGGPVLDTKSEAYQQEAQELVINESILLQTLGFEVAVDHPHTHVIKCTQMIRGRFKIAFGSPSKDLAQTSYFMANNSLHLTTFCLQYKPTVVACVCIYLAAKWSQWEIMRSSDGKDWWEYVDPTVTKELLDELTQEFLRIFEACPSRLRRRISKEQVASKRRPKEGTSEIDSASTAKHIPSSAASVSSIDSGLPGSGNSESSISTQDLPASSQGDSFSSQEASHGEGEGLALQDVNMGLPMMETSMFSLDTEYMSSTGYKPRHGQPSTQPDAEPGKPGDQLGHPVKKSLKEYWEQKERERVKNVQQSREMAQPRPSQTASRPSTMSHQTSHFSKGGTDLPHADQRYRGEGYHSQGGQKHRPEDRHMPPDLRRAEKPPGDRQEQSGGHSQAKSSGRPTDLRPNRDQRPHSQHRPHDPGSQPSQGANVSDSRYSKSTDQYHKHSRHSLPSGSSDRKQHSGSSVQGKEHKRNGFESRDHGANPRLPENNTRLPSSAPPPKPHLPVSQRPHHTETPNAHSLEKLPTSDLPGKAHAEMLRLSKSEMYRSQRPENQGNVKSEKHRTPSAETLRIPKSQSLKPQRSETPKGTPAEKERTQPAIPPLVPVDVKKEQRSAVETQRAELPQPIDQELPKPQRPERVLIQQPELAKVDRRVASVSVKHEPSEVVKTEGMFLHRSDTVMLSKKEVSGTKSAGVSKTEAPKSLKSDLLSKSHKTEESRLPRTETHTVTQKVENVKQLTSDMSRSKEAEVHHAQKPQQLRAVKTEPGTPALQTGAEKSDVTRAQKVIPLSQPLRPETLKKQSIKQGQGQTQRLSTPKSQIPQVNQDRSLLDKDSGMTSTKLLAKSQKISIPTVQGQVCVKLETPDVVAPPKPATHRKPPMPPASKPEAPVPAKPIAHSSEKVTVAKSKPGTITSESPEKAKPQKAETVTPQKTDQQSKPQTPKSQKSTTPRSRGSPGVAAEQVPKPPKIVEAPKAKVDPGKASLLNVVWEPAKPLEVLKPGVSDEMADSESVDADIDKLINAHMAEQSKYQCHEPPPILDLKPTVPPAHTSEPRERKRERDESCLPKSYREKESHHRKKRSEAHRSRDSPHKHRHSSDHRKRSRAEAEGLQSSVQPQASATEEAEDTQPHSSILTTSSGIRLKIKGLSNSMNSGTAKKSRRPRPAGRPARRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1H4</accession>
    <name>A0A8B7Y1H4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Fibrillin-2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110977321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087013.1">
        <property type="nucleotide sequence ID" value="XM_022231321.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977321"/>
    <dbReference type="KEGG" id="aplc:110977321"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000023">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000071">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000133">
        <property type="entry name" value="Fibrillin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000003">
        <property type="entry name" value="fibrillin-1 isoform X1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000002">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000017">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="49"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.290.10">
        <property type="entry name" value="TGF-beta binding (TB) domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017878">
        <property type="entry name" value="TB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036773">
        <property type="entry name" value="TB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052080">
        <property type="entry name" value="vWF_C/EGF_Fibrillin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333:SF5">
        <property type="entry name" value="FIBRILLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47333">
        <property type="entry name" value="VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="39"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00683">
        <property type="entry name" value="TB"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036312">
        <property type="entry name" value="Fibrillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="49"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="48"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57581">
        <property type="entry name" value="TB module/8-cys domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="40"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
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        <property type="match status" value="32"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="9"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5034924705" evidence="11">
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            <begin position="25"/>
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        <location>
            <begin position="202"/>
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        </location>
    </feature>
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            <begin position="240"/>
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            <dbReference type="RefSeq" id="XP_022087013.1"/>
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    <sequence length="3203" mass="344934" checksum="7FD451125F9DF9F6" modified="2022-01-19" version="1">MELVRGVVLRLACLCLMFLTGTLAQEQGPALGPVPGTDVGSGPVVPVGRVPQGAPPQGVPSQGAPPQGADAAQTRSSQYRIISGPNVCGRRLYAYCCPGWQLHPGLQQCTKPICSRLCTSGYCRTPNTCLGQECAFGGINCDGVGADTTGVGGDYEIVDYGGVGGDYGLPVLPEPPTFCGETGCSGSGIVDGQYPLPGPGPFDPICNPECLNGGRCISGNRCSCPVGFMGSRCQTDFRTGQCFTQFNLGICSGEIPGLQCTKALCCSTIGQGWGSNPCEACLTFESPCKRGFVIDARTGLCTDSNECHVIPGLCQGGTCTNTIGSYACVCPQGYALNLLTLGCEDIDECISISNICYGGECRNTPGGFLCICGPGFTLSQDGTSCYRSSGEDDINECITIPNICAGGECRDLQNGYQCICRNGYILSQGGISCSLRPGGLDINECISIPNLCSGGRCLNTQDGYQCICPTDYTLSQNGLSCVTEEDRNVCTTIPNICAGGECLNLPQGYKCVCVGGFIQTQNGVICSGGAGEIDTNECVTIPNICSGGECLNTQDGYQCICRLGYTFGPNGMQCTQEVLPARGLCFIRYDQSSGECSSELTRIMSLEDCCCSLSVAKAYGSSRGNCQPCPRPNEAAYTDLCTKVLPPGPIRDYCSLNPNICTNGDCVSVGDTNFRCDCKEGFRRQTQTVCIDINECSEAGRCVNGECNNVQGSYYCECNPGFELADDRMSCQDINECGLNPNVCLHGTCQNRIGSYECLCFPGYKLSVDSKYCVDINECSNRDVCINGECENLGGSYRCVCREGFKESSQPGQCIDINECEEGPADPCGKMGDCVNIQGSYRCHCPMGYTQGSSGCEESRHAYCSLHSREGRCTIRSTIQVTISQCCCNVVTMEQSAGWGPTCQPCPAQGTMQWEKMCSQGPGRDSLGININECMLFGDLCANGMCEDLVGNYHCRCNPGFEPDVTAKDCNDINECAINRLLCSGGACRNSPGSYTCECPEGYEFDIASVQCRDINECLRDSQCLNGRCQNTLGSFRCECTILGTSLDESGRACVDNRLGTCWTEIRSGRCESDIMGLMRKSECCATFGQAWGSPCDPCPMSLGDCQRGYTLKNGKCEDINECELNQMVCQNSECQNTVGSFRCICEQGHTLDTTGRNCIDLRSYQCFLDYSEGQCHDPIQGLYRNAVCCCSMGKAWGSLGQCYSCPLPGTVEYNTLCPRGPGYADTRPTPELMDGSSVTIDINECNVFPDVCSNGICRNMIGTFVCECDMGYALDQYSYHCVDIDECRIAFGACGNGTCENRPGGFTCNCNPGFETSMMMQMCTDIDECVVIAGICRGGQCINTVGSFQCLCPPGQELSDDGRICKDIDECSRGNDVCSNGHCMNMVGGFRCMCNPGFRPSMNFKSCEDMDECSMENGGCEQTCVNTPGSYECVCDVGYGLMHGQRQCRDIDECAESVDICGGGICENSQGSYSCTCLEGFRISPDYSSCIDIDECTMADDICGAGTCINTQGSYNCRCDEGYAIQGSFLSCLDIDECTMGIHNCAMHSQCVNSRGSFRCQCNAGFFPSFDACIDIDECATQIHECDRENAVCMNTEGSYECICNEGFTGNGLECNDVDECMRNPELCPNGQCLNTPGSYECDCDMGFLPTENRDDCEDIDECTISFICVFGTCINVPGTFRCECNEGYQLDAGGANCTDLDECAEPDTYCVSGECTNTIGSYICICPEGFTLTPDGSVCLDERRGLCYANSPDRGDLAGSTCTTILGRDIPRYECCCTLGTGWGDPCEPCPAVNSTEGQLLCPTGPGFKPVPKPDGPDVPGATPVPGGPDGPGGTDSPDGPDGTDGPIVPPDLTTDIDECAIFPFVCAGGRCVNTLGSFMCVCPVGYTLDEDSRSCRDINECELSPYICGAGTCMNTVGNYTCMCPPGFMLMDMFSGRNCMDMRQLPCYHYYNETAEPQCSASYGMNVTQKMCCCSGLQGAAWGISPCSKCPDMFTEEFRIMCGIAPGFFIDPFTGLPKDINECEVSDLCLNGACINLEGTFRCDCRLGYRYDPIKFQCVDIDECSEGMSFCRSNAICRNTIGSHVCECRAGYTLATNNVACININECQESPNICGRNGRCVDTMGSYRCDCNIGFAESFDGKSCDDIDECQQRIGSIGVCGNGTCRNTFGSYECECFGGYELGQNKDCVDINECITGVGACFNGRCVNIPGGFFCECFTGFEPSFTGETCEDVNECLKQPLLCPGGRCQNLIGSFQCVCDDGYLLAPDGQACIDIDECATLTDPCLDGVCRNTQGSFICECQPGYMPTSDGLTCVDMRELTCFTGFERGQCVAPLMGNHTLTACCCSMGSGWGIPCEVCPLPQSSRYIDLCKKGQGYAPTVFPDIFEDINECKQFPDICSNGYCINMDGSFRCECDLGFVLDETGHACVDVDECENSLSACGYNSTCVNTAGSYECICGEGYQQGRNGKCHDIDECRRDRDYCAFRCQNLPGSFRCICPHGFVITDDGRHCRDLDECQTSANNCRYMCKNLIGKFMCTCPEGYSIMGGNGNMCKDINECLDYPCSNGRCINMEGTYRCDCNTGYIPSFDGKQCKDQRTGVCYATTDGPCSAPANTVPVTRDSCCCSGGLAWGPQCEECPNFATPEFNDLCRDSGPPITDPCTTIIGLCANGQCIAAQGGFICQCHTGYVLTPDGSRCVDEDECSRDINPCPHSCQNTVGSYTCDCQEGFTRGRDGVTCVDVNECVLGTHDCQFDCFNTVGGYECRCPDGMAPKDGSCIHVDVCAVSPDICGPYGTCRTTADGYTCDCQRFFTLDPTGKKCVDIDECQTQPNRCQYGCRNTVGGYRCNCPDGFSQHYYWNRCIDDNECNQPGVCGQATCYNTEGSYRCGCSGGYNFDQQNLVCTDVNECATGFGGGYQPCSYGCQNLPGSFICGCPPGYVTVAQGACVSTYGQGGSYSGQYGQYGQSQQTPYGQTHYGQVGQQRYSQTQYGGQPGYGGQYGSQYGGQTPYGQPSGHQAGQTTGGAQKPCYHCQLNNGRKRRNVDTALNEVPQPEEDHNVTVVEETPTNNTAEGLTNSTETAENFQGVHAKPGKVVYLNIPIEKARRRFRVAKFVTGYSKDIGAMQYKLVSGNEDDFFIIQDKKEGVALIRLHKTVKEHAIFKLEVEGILKPTNEEMAEALPKELEEPVMFEIEVHIVTDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2K4</accession>
    <name>A0A8B7Y2K4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110977504</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022087408.1">
        <property type="nucleotide sequence ID" value="XM_022231716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2K4"/>
    <dbReference type="GeneID" id="110977504"/>
    <dbReference type="KEGG" id="aplc:110977504"/>
    <dbReference type="OMA" id="MHYASTY"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
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        <property type="entry name" value="Sperma_CUB_dom_sf"/>
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        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
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        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034720823" description="Metalloendopeptidase" evidence="9">
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            <begin position="20"/>
            <end position="610"/>
        </location>
    </feature>
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            <begin position="76"/>
            <end position="273"/>
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            <begin position="496"/>
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            <begin position="24"/>
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            <begin position="435"/>
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        <location>
            <begin position="24"/>
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        <location>
            <begin position="455"/>
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        <location>
            <position position="173"/>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
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        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
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        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
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    </evidence>
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    <evidence type="ECO:0000256" key="10">
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        <source>
            <dbReference type="RefSeq" id="XP_022087408.1"/>
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    <sequence length="610" mass="67963" checksum="9C72EBF357666628" modified="2022-01-19" version="1">MTRLLLVLIFFTFKKSACGAKDNSVDYHGPHPESIHPDPPEQTETPGAFQSDMMLTDDQAEEITYSFLFGDVHPRRAVRTSRWPQAIIPYEIDGNFGEGMRTKIREAMDWWREDTCITFEEYTPSGNPDSDHRVRFRKVASGCCSDVGMINHFPQYISLEENSCDLTGTIAHEIGHTVGWWHEHSRIDRNEYVTLRPENIQDGEEKQFVQHDSETFGIPYDVESIMHYASTYFSKNGKLTIEPKYPLDMFKMGNRKFFTFYDKKFANVMYNCSQNCEDLQCENEGYVGKDCVCHCKPGYSGQHCEVDNGDSVDDGGCIRELEADINIDKVFTSPGYPKGYGPNLFCTWLITGPEGTTVSLSFLVFDTEASHCQNDYVKIREGPDIYNGGDRYCGHTPPETIQSVGNRIMVMFMSDGIISKKGFLAQYRADNVSVPPTTTQPPLPTTLPAETTQASTTTLPAETTRASTTTMPSETTQASTTTEIIIPKCQTVEGTCGGTFKKDSGCIASPNFGHGEYNNDEECVYYIQVKAGKRVELRVEQLDVEHQATCTWDKVEIIPGPTLGSVRMCGESPPEGTIVSLDNTMTVKMISDALVAGGGFAASFEAITVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5Y0</accession>
    <name>A0A8B7Y5Y0_ACAPL</name>
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        <submittedName>
            <fullName evidence="11">RNA exonuclease 1 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110977424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
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        <property type="nucleotide sequence ID" value="XM_022231539.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA exonuclease 1 homolog"/>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REX1-like_exo"/>
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        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCCH"/>
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        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EloA-BP1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
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            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
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            <begin position="7"/>
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            <begin position="1261"/>
            <end position="1281"/>
        </location>
    </feature>
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        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
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        </location>
    </feature>
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            <begin position="135"/>
            <end position="157"/>
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    </feature>
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    </feature>
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        <location>
            <begin position="241"/>
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        <location>
            <begin position="265"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022087231.1"/>
        </source>
    </evidence>
    <sequence length="1540" mass="168996" checksum="3A391E3EF3089A02" modified="2022-01-19" version="1">MFTSCGNFRGLNCPFYAQGNGMCRRPYCHFRHVRSSATARTDTEKLQPTKPSGSIDDVYPQTANVSAYVVVAPPTPAASSAPPQDAPKATPSPVQYVPTPIAQIALARRRHKMASSQSSQNAGRKTPTPMYIPTPLSQIAAQPESNSSSSQKYQLTKSPEKSWDETEYDPTSTSLMGYSKSDKYSLDHKLHAPAGENEYDPLENGSLFTVSKQKAPSPETSPQRGQPVGGSKGISDECNHKPTQSSSLGEQTVESGGASAKAEKDEDGLYDFDDLEENVGDDCTDEVDEYSPLPDHDDDTLSPHVSAKYTPTKKYSISTLHSEPGNDSEYDPCSNFSSGESLRKQHEQEKRKELSREEESSDSDALVIDDKADNKRKASSSEDEPAQKKQKCSSDEDNTVLESGRCLTDEGVCRDWLSDGAQENFLAATSVNFDPPSDPVGSFNPSYSYNPSETHSGKEKCDSGSEELNPMAYLTEISKATDDKCTKERPKPKMSQAVKEMVSQDRKARFQEIKGGSSKSKALGEAKQKSVTKKSVETPKHKDSTDEKQTCTSKTEQKQGKVLKQKSTNGAKGEPQVGEYNSNDGEVSPKSRPAVSSDQLSSFFKRMNEQKSKKAKVKSSHETYQPQNKEISKKTDHDAETKKSKVLAGHKNTFPKLPRKAGTVGNKVAGSTGKEDASSIAGSQDLPKSDDVIVIDSSSSSDDCLPQLGSQSTMANGASEESGTCSFTGKQIFAAKVSNRKASTKLLFGDDSDSDSSDVQIVQRSEDEIMLISDGYSSTDGKQITQQTKHHSTDKQGKPTSAVKQQKNSHTVKKPSTNAHSSKPVADRTPSQSHQGAKSVRLDHSKQDSSYQAVKGRLSVKVNIGNSSQSQTVPSVKKRQPQSPFRSEEGNSVVAMDYGVESVSTSDYEEDAELSDDFDINDVELSFSESDTFEECLRIFQEESSKVPVKKPREPQKLKEKQLKTEDLLLSTGKQRVAHSSKFQSAQAKYRKCTPRPKARPTPLQVCHNRYMQAQQQLRQQWQNGPTQQVKDSPAGSKPSGSAGKRIAHVPSSSKPSSLPKSPASSSQPAMGVNARIQLKYSIGHGAGSNTGRKTVAITAPKGERRVAHLPKKVNPRPIIPPDSANKVPSSVRQRYLNLFIDEFLKTTQTEQDAFDQGLKEEKSVYDRATSRNIYLNLSINTLKRLRSAQAPGQSKPASPGKASISHEAIIGGKPATQHTYTLNRSLHSRLASQEEKYEGAFLYKKLKPYLLSEEELVANRYPRPSDTPGHATVREDDTKKCTSADPNQRFCSRCGKTFLRRPDGHYITRESCTYHWGKFWHKKVGGSFEGRFNCCSGTSDAKGCCIAKYHVTEDKTSNLTGFMRTVAKSPPADGNAGLYSLDCEMCYTVKGLELTRVTVIDDKLDCVYDSLVKPSNEIVDYNTRFSGITEDDLKSATTTLQDVQAILLSMFSSDTILIGHSLESDMLALKMIHSTIIDTAVLFPHKRGLPFKRALRTLMAECLSRIIQNDVGGHDSKEDAKSCMELIIWKAKQDAKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y925</accession>
    <name>A0A8B7Y925_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Vesicular inhibitory amino acid transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 32 member 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Vesicular GABA transporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110978777</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals. The transport is equally dependent on the chemical and electrical components of the proton gradient. May also transport beta-alanine. Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70987"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70983"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089743.1">
        <property type="nucleotide sequence ID" value="XM_022234051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y925"/>
    <dbReference type="GeneID" id="110978777"/>
    <dbReference type="KEGG" id="aplc:110978777"/>
    <dbReference type="OMA" id="MKWTHIA"/>
    <dbReference type="OrthoDB" id="6021076at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060077">
        <property type="term" value="C:inhibitory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140800">
        <property type="term" value="F:gamma-aminobutyric acid:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015187">
        <property type="term" value="F:glycine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051939">
        <property type="term" value="P:gamma-aminobutyric acid import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000062">
        <property type="entry name" value="Vesicular inhibitory amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF689">
        <property type="entry name" value="VESICULAR INHIBITORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="21">
        <location>
            <begin position="105"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022089743.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="56361" checksum="07FD7C6CB62BAB30" modified="2022-01-19" version="1">MSYAPIPGLGAPVARIRHFVGNLLPRGKPDEEHLHFAKCDSTELSVLGSGEEGRTPETGVDGGAENGKAPAVNGAVSAVGNPVASAGQAARSYGEASNVNIAKKQISTWDAGWNVTNAIQGMFLVALPYAVLHGGYWGLLALLLAAAVTCYTGKILVECLYVTDDVTGLRIRVRESYVDIAKEVWGDRFAAQIVHTAQFIELIMTCILYLVLCGDLLSNSFPTNKLDETTWTMLATFLVVPCAFLRDLKAVSRLSFGNAVVHVIINLTLIGFCLSYAALWHWGDVAVQVDIHYFPVSMGIVIFSYTSHIFLPSLEGSMVERPKFNKMLYWTHALAGLFKALFAYLCFLTFGLGTRDIITDNLPTQGFRATVNVVLVIKALLSYPLPFYAAVELLERAFFSGRPRTLFPSCYALDGYLHPWSVALRTLVVIFTMLLAIFIPHFNQLMGLIGSFTGTMLSFVWPCLFHLKIKWPEIPWYQKLFNILVILSGCVVGLIGIIYSLEALIKISKEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA83</accession>
    <name>A0A8B7YA83_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110979024</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090159.1">
        <property type="nucleotide sequence ID" value="XM_022234467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YA83"/>
    <dbReference type="GeneID" id="110979024"/>
    <dbReference type="KEGG" id="aplc:110979024"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034303693" evidence="1">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022090159.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="21216" checksum="D1E84967DE18A1BE" modified="2022-01-19" version="1">MFRFTAILLVLGMVAIQASRARPETRRYETNLKDSLKRREDLDLVNQLLERLLASEEKREVQKDCPEATICSIGECYYVTDTPPGYGLVLYNRNSDKLLFQFDEDTLRRLDDKKTNVTVALLSTYFPYTSEDFEVDGETYNVKVDNVTVDDEGNITVDGFCLVLKEEWSRQVNWIRGLFGFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBV4</accession>
    <name>A0A8B7YBV4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="39">ATP-dependent DNA/RNA helicase DHX36</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="41">DEAD/H box polypeptide 36</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="40">MLE-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="46" type="primary">LOC110978458</name>
    </gene>
    <organism evidence="45 46">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="46" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell projection</location>
            <location evidence="7">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022089171.1">
        <property type="nucleotide sequence ID" value="XM_022233479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBV4"/>
    <dbReference type="GeneID" id="110978458"/>
    <dbReference type="KEGG" id="aplc:110978458"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
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        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
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        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
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        <property type="entry name" value="HA2_WH"/>
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    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF237">
        <property type="entry name" value="ATP-DEPENDENT DNA_RNA HELICASE DHX36"/>
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        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
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        <property type="entry name" value="DEAD"/>
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        <property type="entry name" value="HA2_C"/>
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        <property type="entry name" value="Helicase_C"/>
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        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="30" id="KW-0007">Acetylation</keyword>
    <keyword evidence="35" id="KW-0010">Activator</keyword>
    <keyword evidence="32" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="38" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="21" id="KW-0221">Differentiation</keyword>
    <keyword evidence="33" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="23" id="KW-0347">Helicase</keyword>
    <keyword evidence="22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="27" id="KW-0391">Immunity</keyword>
    <keyword evidence="17" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="25" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="37" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="45" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0678">Repressor</keyword>
    <keyword evidence="28" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="29" id="KW-0779">Telomere</keyword>
    <keyword evidence="36" id="KW-0804">Transcription</keyword>
    <keyword evidence="31" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="26" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="43">
        <location>
            <begin position="217"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="44">
        <location>
            <begin position="478"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="42">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="42">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000256" key="42">
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    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="RefSeq" id="XP_022089171.1"/>
        </source>
    </evidence>
    <sequence length="1002" mass="114560" checksum="5C81B34C32C99B29" modified="2022-01-19" version="1">MIASARFTFCGGLRNGRRSFSPLDRIKLTFDQMSKARGRYFNSHRGRDRGARWDGGQEDGRAGPSSRDGEEGGSGWGQGHGGGGKMGGPPPGLRGRQIGMWYAARGRAKKAAEEARNRPVIGMQPEHERHICKLLDDVRNQGSDDEEQLENMEVTPRKNPQEEQFHSFYSHVLTRDAGLDDRLRLELETKLANNRQYRDMQEFRKKLPSYNMRHELLRLISENQVVVISGETGCGKTTQVPQFILDHHIQQGQGSTCRVICTQPRRISAISVAERVACERGEACGNGNSTGYQIRLEARFPRQQGCILYCTNGILLKWLESDRLLQSVSHVVLDEVHERDIISDFLLVILKDILPKRPTLKLILMSATLNAELFSAYFHGCPMANIPGFTFPVLEYWLEDVLQMTKYHPPEQRRRHEPVWLKFRRGKRYREDELKKEEEFKERFSNYIVEMRQTYPEEVVYHLENMDHENMDLEMVSSVIRYICLNKPEGALLVFLPGWEQISKVNDLLTQQQMFRNNNFRIIPLHSMMPTVNQRQVFERPPPGVRKIVIATNIAETSITIDDVVYVINLGRVKERNFDVENNLSTLKPEWISVASARQRRGRAGRVQPGECYHLYNQLKAAMLADYQLPEMLRTPLDELCLQIKSLKLGSVHGFIEKALQQPDPGAVDLALESLTRMNALDENEELTPLGYHLARLPVSPTIGRMILFGAMFCCLDPILTIAASLSFKDPFVIPLGKEEMADAQRKRISEDTFSDHLMLVNAVAGWEEARDRGRQAESDYCWRNFMSITTLKMLDNMKTQFCELLASIGFVAGKSCKQRAANRNSDNRQLVKAILCSGLYPNVAQVKKNSFNRREGRLRPAKIMTPQDGRVKIHPKSVNSDEAHFPTNWILYHLKLKSTNVFLHDTSAVEPYPLLFFGGKIGVTREEGLEMITVDDHIKFSAPARIAYLVKDLRCELDKLLQQKISQPGMTCWRQDTKEGRIMQAIIDLITTQEDSRQSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCS1</accession>
    <name>A0A8B7YCS1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Muscarinic acetylcholine receptor DM1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110979512</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091048.1">
        <property type="nucleotide sequence ID" value="XM_022235356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCS1"/>
    <dbReference type="GeneID" id="110979512"/>
    <dbReference type="KEGG" id="aplc:110979512"/>
    <dbReference type="OMA" id="IMAMFIT"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="47"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022091048.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="50020" checksum="07B8ECBB0C301DF2" modified="2022-01-19" version="1">MQSANTVSGMNATDASPTESREDQPLGTGQIAIAITSSVVCLITVMGNLVVLGGFCTDRRLRTYVNYYIVGLSLADLVAGVFTMPLYTVYWVLGHWPFSAALCDAYLYLNHVFIHISVLGILVLAIDRYQAVYHPLQHLRRRTPRHATFMISVSYVVPFLLWLPWCLLWPYLVGTRNIDPGYCYPQYVADSLAFSILAPVCFFWIPVPITSVLYWRIYRVIGHSKHKGPVMISDLGRPPSGRDGTPAANQSSPLSLEKSDEPTTSNTSVHHSAHENPAFETPMEPDSVILNNPVTPTGHCSVGFETTPAIYSITHSPDHTPTAHRVLNELTGLTIEGKPLERDCTGENHRATRTLTLILVSLLISSVPWSVFVIIYSICPNCIPLVLYQTSVYLAHMNSTVNPFCYGVANPLYLDVLKRPVCCSKGRTTVPRDGHCSRRPYTIGVQHSTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDI8</accession>
    <name>A0A8B7YDI8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Uncharacterized protein LOC110978762</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110978762</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089715.1">
        <property type="nucleotide sequence ID" value="XM_022234023.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089716.1">
        <property type="nucleotide sequence ID" value="XM_022234024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDI8"/>
    <dbReference type="GeneID" id="110978762"/>
    <dbReference type="KEGG" id="aplc:110978762"/>
    <dbReference type="OMA" id="WRISIYS"/>
    <dbReference type="OrthoDB" id="6064659at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665554" evidence="10">
        <location>
            <begin position="23"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="12">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="126"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022089715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022089716.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="36883" checksum="0B214FC9CAF774DA" modified="2022-01-19" version="1">MFTLPLWVLIWGMTFQLLFVLSKQGNGPGYLGCFGDYYNRALPIGPAIDRNKQSVEWCFRYCLESSSTKYKYAGVEFTTECYCGSNEDYDKHGNKPDSECRHRCPGHNDQICGDNWRISIYSISQGVCSNDIGPPTNGDHTITNPRSLDYNLNNFKFFGTHVDFSCDVGYTLRGASSIECIDTGYNNVTWSDSVPRCEVPTTTMPSTTFQSTTVAIAPSSTRFNRDTPGPNNPNTGELKTATIIGIAVGAGVVTALVLSAIFIWKKRRNTRKKRPAVTLAKTGDRYTNNAYGLVSHSVSNQVNAPVYSAVIQQKSHCDDVYTTPDDVTSSRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDQ0</accession>
    <name>A0A8B7YDQ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089781.1">
        <property type="nucleotide sequence ID" value="XM_022234089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDQ0"/>
    <dbReference type="GeneID" id="110978805"/>
    <dbReference type="KEGG" id="aplc:110978805"/>
    <dbReference type="OMA" id="CFLELET"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF36">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022089781.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28702" checksum="41AE8BEEC232BB3B" modified="2022-01-19" version="1">MSDSWLNIVNLCHFPHFISYYGQAYQIDPRNVQALLLKGCVLKDMSKTQEALLHFREAVRMAPYRYEAHQGLVECYIKARKIREALTTASNACKVLGNSARSLTLFASVLAKDSLTVEKAKTMLEKALAQEPTYLDAVYLLAEVLGEEQQYTAAIELLRRQLHHQSTCKLHQMLGEFLSANNELQEALDQYSIALGMDPTNKKVLDGIQKVEKVTDSIDRGQDDDMEALEESGEDVDFDASDTEVSWADNEWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFC7</accession>
    <name>A0A8B7YFC7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lethal(3)malignant brain tumor-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">L(3)mbt protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18 19 20 21" type="primary">LOC110979530</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091091.1">
        <property type="nucleotide sequence ID" value="XM_022235399.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091100.1">
        <property type="nucleotide sequence ID" value="XM_022235408.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091109.1">
        <property type="nucleotide sequence ID" value="XM_022235417.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091119.1">
        <property type="nucleotide sequence ID" value="XM_022235427.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091126.1">
        <property type="nucleotide sequence ID" value="XM_022235434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFC7"/>
    <dbReference type="GeneID" id="110979530"/>
    <dbReference type="KEGG" id="aplc:110979530"/>
    <dbReference type="OMA" id="QHNIDGE"/>
    <dbReference type="OrthoDB" id="8188861at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20101">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20102">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20103">
        <property type="entry name" value="MBT_L3MBTL1-like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09582">
        <property type="entry name" value="SAM_Scm-like-3MBT3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000007">
        <property type="entry name" value="Lethal(3)malignant brain tumor-like protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.30:FF:000001">
        <property type="entry name" value="Myelin transcription factor 1-like, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050548">
        <property type="entry name" value="PcG_chromatin_remod_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038603">
        <property type="entry name" value="Znf_FCS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247:SF131">
        <property type="entry name" value="LD05287P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12247">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02820">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00561">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51079">
        <property type="entry name" value="MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="MBT" evidence="13">
        <location>
            <begin position="341"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="13">
        <location>
            <begin position="449"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="MBT" evidence="13">
        <location>
            <begin position="558"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="15">
        <location>
            <begin position="877"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="769"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="717"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022091091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022091100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022091109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022091119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022091126.1"/>
        </source>
    </evidence>
    <sequence length="944" mass="103031" checksum="18A1163084A5175D" modified="2022-01-19" version="1">MADTESGMAEQPPKRRLKVEKEAKENPGEAETECCENEAKRNGQSTDSDDIDLSVPEGEQLDDEDPPVIPNATAEKPSPGNNSTSTFPPAEMPTLEKSDTDPLLSATQEEAPTEGPGLTVPEGGSNSEENGNEEVKGEEGGGAEAEGCGGEGMEYIEWNADGIGILPGSDMKFKLNEFGVLELIMDPDPIEPADEPSPSPAPTPASEAGSDISSEKSAVFNNDKKYATSLDDLQKQPGSKPLMCVCEQCLKEGPITEFCKSGRFCSQSCVGAYASKQGSLRKESEKKKSSNMMLKKKVGRKPKSPGPEGKAHLHGDLKMTINIKGMDKSPIANKPGKKKGFTWSTYLQQERALAAPAKFFKDAFPSGKNNFKVGMKLEGIDPKHPSLFCVLTVAEVRGYRIRLHFDGYSECYDFWVNADSPDIQPAGWCERTNHKLQYPKGRGFTADNFSWSSYLKMTKSQAAPRSLFKSYENDCVTPQGFRKGMKLEAIDKKNPSLICVATVANIMESRFLIHFDAWEDTYDYWCDSSSPYIHPVGWCEENGKILSPPNDYEDIVNFTWADYLARTKSVAVPTRAFKPRPPVGFEVGMRLEAVDMRNPSLIRAATVAELDGHRLRLHFDGWTDDYDIMVDDDSPDLHPVGWCNKTGHPLVPPIRPSQLVANQGQAGCPTPGCNGVGHIKGAKYTGHHSAFGCPYSLLNMAKETTLIDRLYTGSKSLSKDGKKSPAESPETKKCPTPGCDGSGHVTGKYSGHHKLSGCPLNEKNLNVVNGGEGKLVNPSPSPSPRGPGRPPLPLALGRGKRKHKGTSLLLPQKKKKKSHPDKDEKSSKTNLHHQLHQSVFMSAMSPNPARDLPLCWEQHSKLLPGLANLSCSTVAKWSTEEVADFVRKLPGCGDHASKFAEEQIDGEAFLLLTQTDIVKIMTIKLGPALKIYNAILILKSAEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGC7</accession>
    <name>A0A8B7YGC7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022090701.1">
        <property type="nucleotide sequence ID" value="XM_022235009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGC7"/>
    <dbReference type="GeneID" id="110979313"/>
    <dbReference type="KEGG" id="aplc:110979313"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022090701.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="46537" checksum="EF978005C470559F" modified="2022-01-19" version="1">MLSMHSPDSTKMKTLTNNLQNARINDQENQYPMKTKQLKVLGDSQKHNIIHTSKTPSKEEKRKELKEFKKKQQDLLQDEPLLRENPRRFVIFPIQYKDIWEMYKKAEASFWTVEEVDLSKDLPDWEMLKKEEKHFISHVLAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQIAIENIHSEMYSLLIDTYIRDPDERTFLFNAIETLPCVKKKADWALNWINSDSTTYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMHGLTFSNELISRDEGLHCDFACLMFSHLVHKPSEERIKAIIREAVLIEQEFLTDALPCSLIGMNATLMKQYIEFVADRLLLELKCTKIWNVENPFDFMENISLEGKTNFFEKRVGEYQRSGVMASKEEQVFRLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGV2</accession>
    <name>A0A8B7YGV2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110979411</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090876.1">
        <property type="nucleotide sequence ID" value="XM_022235184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGV2"/>
    <dbReference type="GeneID" id="110979411"/>
    <dbReference type="KEGG" id="aplc:110979411"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090876.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24213" checksum="374FE8CB6C03DFE2" modified="2022-01-19" version="1">MPTTPAENRQTGTPEMVLLTDTSKAPSNRAAEMTMSLSPTGRITERYTDSLRLTSDPTTEEIRDGEVTTVTIETTMPAYESSSRPPDDIETLKPNIAEQPDDNGDDKELVDKPEQKKKSKLTWLVPVGVCLVLLGIPAAFVCHYICKKDNSVHALDRLMFKNKGVALPKPKLIKPRYQGATPMTPPKATPVSTPTQPMIGMVEVHKVSGPVDLAESIENNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH62</accession>
    <name>A0A8B7YH62_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 65-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110980311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022092584.1">
        <property type="nucleotide sequence ID" value="XM_022236892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH62"/>
    <dbReference type="GeneID" id="110980311"/>
    <dbReference type="KEGG" id="aplc:110980311"/>
    <dbReference type="OrthoDB" id="430821at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022092584.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13524" checksum="F9EE33ECF969EC31" modified="2022-01-19" version="1">MIVAGDYIDLTIGITLGISTMAAAALGNLISDLAGVGLAGYVEALAARVGVHPKELTPEQADMRQTRWMAGIGRALGLMIGCLAGMLPLLFLETREQAEEQASEGDTSGPDEQPESQQVFRYGFEAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHB8</accession>
    <name>A0A8B7YHB8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110980351 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092643.1">
        <property type="nucleotide sequence ID" value="XM_022236951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHB8"/>
    <dbReference type="GeneID" id="110980351"/>
    <dbReference type="KEGG" id="aplc:110980351"/>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092643.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41821" checksum="E2996F817856963B" modified="2022-01-19" version="1">MYFYCELERKQQKISYLRDLVESYPCLVVESTKSRHYKCWAEKKMEGSPWQPDLDWKQRDKELVDDFSWSEEDLSDRVATPFKFVSVGRGSRKRRDPQDVRLPRIFLDRIRQKNFPRRPAGRGNILKTFSSQSLSGSIQPQDSLWMSSQASPSSLSEDFLGAASRGLTSDILAGKACLMEKFLGKPMAGQGGFNPFGNKHQRSSGSLRSTQTAPLLDFSSREQWPGVGASACQSNCGKNGPKKSLSLQDALNAISRTPNQWDRASLDSSGKGSGDGSRKWRRTKRSQGRVSQGQNGSQDKEGAPRMNGSEGVAACSTVGSALPENGSKERGSENDLSGTSRQEGEVEICTYFTSYWRVVTSVVPLMVSSDRHALIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHV5</accession>
    <name>A0A8B7YHV5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein ZFPM1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110980014</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091965.1">
        <property type="nucleotide sequence ID" value="XM_022236273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHV5"/>
    <dbReference type="GeneID" id="110980014"/>
    <dbReference type="KEGG" id="aplc:110980014"/>
    <dbReference type="OMA" id="RSNCESH"/>
    <dbReference type="OrthoDB" id="8742770at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19201">
        <property type="entry name" value="PR-SET_ZFPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059121">
        <property type="entry name" value="CCHC_ZFPM2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039746">
        <property type="entry name" value="FOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034731">
        <property type="entry name" value="Znf_CCHC_FOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12958">
        <property type="entry name" value="FRIEND OF GATA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12958:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN USH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25445">
        <property type="entry name" value="CCHC_ZFPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51810">
        <property type="entry name" value="ZF_CCHC_FOG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC FOG-type" evidence="15">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC FOG-type" evidence="15">
        <location>
            <begin position="767"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC FOG-type" evidence="15">
        <location>
            <begin position="1144"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="559"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="819"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1014"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="870"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="884"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1014"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1064"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022091965.1"/>
        </source>
    </evidence>
    <sequence length="1184" mass="130032" checksum="CA0A855E8DC2F5B0" modified="2022-01-19" version="1">MEHLQLRHLTMSVIKRETQCREPTPSPPPRQMAPPMSEVSLSPPPPEVPVPSFIQVTDGGLFAESSVPASTIFGPYKGTIGKVHPRRSEDGDDTTQLTGLKFQDSAGQEYAIDRTDGDQPWWAYIRQATEHNQANVGLFSHNGVLYLKSLKHIPKAKELFLVLSTPLEDVNTVEADDGDLTTSALSKIPSPLIMPSPQPANKGLLEGPPFKCDFCCIEFRNPSNLDAHRVYYCPGTATKPMPSSRRRSTSTTQTVSPNNSTVKTASVQTTETREVPAMHSKAVTVKTVKTFVCQLCQSSFESQSNCESHMLLLHCDEVANLCKFCNFISEDRKGLCQHVFSHVKLTQVEESCCSLPGNSSDPDSGYKIIEKVVVDGGDEKENRYEVTATATKRCRNKLQNSSMQSVLSPGMRHISSSPVNLENNYATNLASPEMMATPSREERCSPAKVIRAESPNGISICVGGARSNRLPSKEEILSCPQCDFVTSRESVLLKHMTHHTSLRKKTPDRGMDAHAPKTDEHHLECSTCHQCNIVFMSKKNYLAHKQYYCASRHAESTSPSIVPNWDSKPGNTPPQVSIKTRTAVSDKMDTSNTRRSLNGSDELGETYPFEVVPPGCSPFDDNELDTNTSPRSVVSLHSTSQLSATPSASLASPNPRCSPKSRQMLGQPLQMIHLDGKRQFLSTGAILQGPQLVLVTPIVIPQSPKNDAAKLDGKLKIPVIRSSRAEQPLDLSTKPKSPPLSDPSNSNGCRPTVITTELSSQHIRAQLLERQSHRCEECKISFSKKESLVVHKQYYCASRHMYSQKGLVRTKQYNVLKPPTVMSSPLHNKSFSPDNLASQSPNLNARPCHFETRNSKPKVSISGQLNSSQAFSSSGTAGSDAATPQTTHHAVSCASSSEHTISSTFALPNGNATHEQSCSTGMRSPNQLWCKTPKLKRAVPEDRNKLDKERSLPPIKRKKNLILDEESRHPLATTIDIGGLTTNGIVIKEEPTGMDSVTTSDTCTYSSVKTVVSSGTRQMLSENMRSRSTPSPHTNSQAVSQTMITIKKEPQDSVPASKRYSGESPRTVSTISRSIGSLQSHLTSAPNRPNLPPRPSEVRHPTTTVTPLTIPMYRHSSPRQSNPSRHMTLSSYLNTANSRPLLRGVKPTVKHCRNCNISFSSLSTFIAHKKYYCASHHQAKNTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIT1</accession>
    <name>A0A8B7YIT1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Usher syndrome type-1G protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110980277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092517.1">
        <property type="nucleotide sequence ID" value="XM_022236825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIT1"/>
    <dbReference type="GeneID" id="110980277"/>
    <dbReference type="KEGG" id="aplc:110980277"/>
    <dbReference type="OMA" id="VMYVGTF"/>
    <dbReference type="OrthoDB" id="76949at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF15">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="30"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="357"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092517.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="47796" checksum="4A396921E4860861" modified="2022-01-19" version="1">MNRFHEAARDGHLDSLRDATRREANKPDDTGRTPTLWAAYQGNTDALRILVSRGGNPDVCDIQGHTALHYTALSGHVNTATFLVSFGCNVWALTNDHRTARDLAAENNHKACLTLLDEVMAEQSAKNRKEVKKLKEKAMGDADKRAKKLQKMQAEHTKWQKKEEKKEAKQSGLYKKKAGGKKEGSSPAVRRPHRNSTGAMFSEITSSNNRGRSKSSLVPGAQHSEDSLSRSTADSRSNASDRNDDNSSDEDEAKRPDIREQGFWQPFAGSNIASTVQSLPSRKPGEADVTQEEDLLNDVDIDHEYGKTNGDPNVPKIYVSKPDDRRHSSTDQNSNELDWNPDDLDDDDDDDVGPSTSDLEFFLAVHNLLDYLPVFTREEIDLTALMLLHDDDFVKLGLPLGPRRKLTDAISRRREAVNNPGVMKDTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YL06</accession>
    <name>A0A8B7YL06_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione S-transferase omega</fullName>
            <shortName evidence="3">GSTO</shortName>
            <ecNumber evidence="3">1.20.4.2</ecNumber>
            <ecNumber evidence="3">1.8.5.1</ecNumber>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Monomethylarsonic acid reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110980139</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:15969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:33409"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.20.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.2" evidence="3"/>
    <dbReference type="EC" id="1.8.5.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022092206.1">
        <property type="nucleotide sequence ID" value="XM_022236514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YL06"/>
    <dbReference type="GeneID" id="110980139"/>
    <dbReference type="KEGG" id="aplc:110980139"/>
    <dbReference type="OMA" id="HRCPWAH"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050610">
        <property type="term" value="F:methylarsonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000009">
        <property type="entry name" value="Glutathione S-transferase omega-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000123">
        <property type="entry name" value="Glutathione transferase o1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="101"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092206.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="26630" checksum="67384817769658B9" modified="2022-01-19" version="1">MSEKHLEAGQPLPPLKDGSVRLFSMKYCPFAQRSRLVLKAKGINYEEINCNLKKKPEFLLERHPDGKVPVFEHNGKVLIESSIICDYLDEIYPDPPLYPKDPFQKAKDKVVMETYASKVIPAFYKAMGSGGQDNETATNLIAGLTLFDAELKKRGTPFFGGQQPSMVDYITWPWNERLMVSDKLMNTLKAKLPDLDAYFQRMLTTPAVKAILNSKEQYQKYHESSISGNPQYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNV3</accession>
    <name>A0A8B7YNV3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NSFL1 cofactor p47</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">p97 cofactor p47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110981146</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">Golgi stack</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094135.1">
        <property type="nucleotide sequence ID" value="XM_022238443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNV3"/>
    <dbReference type="GeneID" id="110981146"/>
    <dbReference type="KEGG" id="aplc:110981146"/>
    <dbReference type="OMA" id="NKDHTDK"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990730">
        <property type="term" value="C:VCP-NSFL1C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000020">
        <property type="entry name" value="NSFL1 (p97) cofactor (p47)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000093">
        <property type="entry name" value="NSFL1 (P97) cofactor (P47)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000001">
        <property type="entry name" value="NSFL1 (P97) cofactor (P47)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="13">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="12">
        <location>
            <begin position="335"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="64"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022094135.1"/>
        </source>
    </evidence>
    <sequence length="414" mass="44388" checksum="51083D08ED30D6BD" modified="2022-01-19" version="1">MADEAQKAGLIADFAGVTGVDADRAKFYLESSGWQLQIALGSFYDNDGGNDGADDDVLFHEASDEFRPSNLRQPEVVDLSADEPETEGAPLAVRGTGRNRPPAPSSRFHTVSDFARDTGADSDSDEEGQAFYAGGADHGSGQQVVGPRKKKSNTDSMINDLFKSAREHGAQEVGAGSSSTSEGTPSSFIFKGAGYRLGDSESGPARPEPGTVGTLPGKEPRGRNIILKLWRNGFSVDDGELRGFKDPQNADFLNAISKGQIPMELIREAKGGEVNLDLEDHRDEEYTRPKVKVKPFSGQGSMLGSPVPTVVSTPASASAAKQDEASANQSVSLDESQPVTSIQIRLADGTRLVRKFNHSHTVADVRRYITTARPVYAGQLFALMTTFPNKELTEDSQTLADGKLLNAVIVQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YP00</accession>
    <name>A0A8B7YP00_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc transporter ZIP12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110981609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094993.1">
        <property type="nucleotide sequence ID" value="XM_022239301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YP00"/>
    <dbReference type="GeneID" id="110981609"/>
    <dbReference type="KEGG" id="aplc:110981609"/>
    <dbReference type="OMA" id="YKANNFA"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049406">
        <property type="entry name" value="ZIP4_12_EF-hand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041137">
        <property type="entry name" value="ZIP4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF30">
        <property type="entry name" value="ZINC TRANSPORTER ZIP4 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21116">
        <property type="entry name" value="EF-hand_Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18292">
        <property type="entry name" value="ZIP4_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="693"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc transporter ZIP4 N-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc transporter ZIP4/12 EF-hand" evidence="10">
        <location>
            <begin position="314"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022094993.1"/>
        </source>
    </evidence>
    <sequence length="723" mass="78741" checksum="D62B936920B3A5F4" modified="2022-01-19" version="1">MAPIPKVDFRVVCIIYLLVFGISSRLHVLAAGEIATEETHHNHGHSDSIFGDPFEEIFGQLREISFGADRNITRDETATVIHLLFEDQLHCSDNFNVSNCHKCLETDSLFSILGIQPSHGLDEENFNRACVVLMYYVADLNSTCAAAANLSVLTYEDFAQNILKRLDSTQNLSEEELEDVLDAVAKTYKANNFAKCFTAETVFEAAVANHQLGADDHELENVAAILISSLVRGFCIGNATELDPEAFLEDIFDTYATDGYLSEEKFQEIVDKLSAGSGGESVSPDPHDHAHRRRRSVLQLSAERRRDRRNAATVTHEGHDHDHDHAHEGEVSLDVHSCFSVDGLFDIFGVNHSVGVTRQQFKELSPALIQQTLRGPCVNNETTVPEGPSAAEVWGYGVLAVFIISLCAIAGVAFLPCLSTDVYLKVLQTMMALAVSTLVGDAVVHLIPQAVGLHAHDATAAGVTHDPTSEDLAYIWKCLVVVVAIYVFFVFESLMQMFGGGHSNSVKPVDDEPGERKRTSSMRLKEEIDSSPKHRSTSNAQFGDVLNEDATDERGHSPHHSKVCHGIGSLPLMILIGDGLHNLGDGLAIGAAFATSIGTGLSTSIAVFCHELPHELGDFAVLLSAGLSFRKALVFNFLSALMAFIGLCIGIPLAANAEAREWIFALAAGMFLYVALVDMFPELIHHNNKNKGTIFLLHNLGLFIGATIILVIALYEDSINISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQJ0</accession>
    <name>A0A8B7YQJ0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC110981589</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094942.1">
        <property type="nucleotide sequence ID" value="XM_022239250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQJ0"/>
    <dbReference type="GeneID" id="110981589"/>
    <dbReference type="KEGG" id="aplc:110981589"/>
    <dbReference type="OMA" id="GKIFNMC"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="23">
        <location>
            <begin position="18"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022094942.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52553" checksum="82ADF3F58008695F" modified="2022-01-19" version="1">MSTSTEKYLQHKVKYPCITVEPVVLVFFISYSMIVTLRAEYITLRIADGLDGTKGSRSAVLGPDDTLCRHLSNQSQEALYAETQSRASYWLLLLNLFQVVPSLVSAPLIGSWSDLGGRKRALVIPIIGYLMGSIVWIIVTYTDGKLWYLLLAEFCLGLTGDFSAVLAVCNAYLADITTERERTFRLILVGITIEVGTGASQILVGYWVVQQGFGVPFWFVVATMLASLVYITVLLKETRGKSGGLENLELFNNRLLDDIYGMFMRYSSKQRRQMMFFMIVLGVHMTILYTAFLLILLYVLSPPLCWTPITVGYYVASALLLGSAGTLLGGKIFNMCVNDLGVVQLGALSFAASLTLVAFSRSTTILFIAGICGSFRFLVSPAVRSRLSKLVDEEEQGAMFSLASSIESIGHLIGPLIFNLMYGITTGIYQGFTFLVMASFYVPICFMTGYYQLTSYWISKHKTVSTSDGERMATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YR49</accession>
    <name>A0A8B7YR49_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110981579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022094930.1">
        <property type="nucleotide sequence ID" value="XM_022239238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YR49"/>
    <dbReference type="GeneID" id="110981579"/>
    <dbReference type="KEGG" id="aplc:110981579"/>
    <dbReference type="CTD" id="84532"/>
    <dbReference type="OMA" id="AIKASWP"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000004">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="8">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="129"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="578"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022094930.1"/>
        </source>
    </evidence>
    <sequence length="699" mass="77752" checksum="D9473686429B1D1C" modified="2022-01-19" version="1">MAGLQKSLLLAKTCYISGHAKVISALVTGFRQPHFTRCLSTSLPHPANQVSTVHIPELETFEKMGHTFESHQQLYQFSLREPDKFWGTLARSRLRWYKDFDKVSEVDWAEGKNAWFLGGKINVSVNCIDRHKEANPDRVALIWEKDEPGQEERITYKQLYDMTNQIANALKTQGVKKGDRVAIYMPVSPLAVASMMACARIGAIHSVVFAGFSAEALASRIRDGDAQTIITADQAVRGGKVIELKKTVDSAVSLCPNIKRVFVAKRTGNPVPMSQTDIPLEEAMSRESTECQPEILDSEDLLFMLYTSGSTGAPKGLSHSQAGYLLYASLTHQMVFNYQPSDVYACVADIGWITGHTYVVYGPLSNGATTVLFESTPTYPDPGRYWEMVERLKLNQFYGAPTAIRLLLKFDSSYVTKYDRSTLKTLGCVGEPLNHEAWEWYNDIVGEGRCSLADTWWQTETGGIMITPRPSSPGAEIHHGPMTPFLGIEPVLMSDTDHTVEMTGNSVSGALCVRRPWPGIARTIYGNHQRYIETYFKPYTGVYFSGDGAHRDRRGHYHITGRMDDVINVSGHRIGTAEIEDAMDEHPAVAETAVVGFPHDIKGEGIYAYIILKEGVSESEEDIIKELKQAVRQKIAAYAVPDLIQITPGLPKTRSGKIMRRILRKVCANQSDELGDVSTLADPSIVEVIVKNHVRISQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRQ2</accession>
    <name>A0A8B7YRQ2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9 10">U1 snRNP C</shortName>
            <shortName evidence="9 10">U1-C</shortName>
            <shortName evidence="9 10">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110981125</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094086.1">
        <property type="nucleotide sequence ID" value="XM_022238394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRQ2"/>
    <dbReference type="GeneID" id="110981125"/>
    <dbReference type="KEGG" id="aplc:110981125"/>
    <dbReference type="CTD" id="6631"/>
    <dbReference type="OMA" id="GPPGFIM"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="12">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="79"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022094086.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="19427" checksum="F7E6CBF355A8394B" modified="2022-01-19" version="1">MNVCCLNRKVVDILPSKMPKYYCDYCDTYLTHDSPSVRKTHCNGRKHKENVRIYYQKWMEEQAQSLIDRTTAAFQSGKIQHNPFNEGGPGGMPPPPGGAAVPPPSNYGGPRGPMPPRGPMGAPMMGGPPGQRPLMQNPPGLMSMGPRPPMMPPLGPVPPGEMPPPGGLLPRPGLPVSNGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSA0</accession>
    <name>A0A8B7YSA0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110981203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110981203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094261.1">
        <property type="nucleotide sequence ID" value="XM_022238569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSA0"/>
    <dbReference type="GeneID" id="110981203"/>
    <dbReference type="KEGG" id="aplc:110981203"/>
    <dbReference type="OMA" id="KGNDWEA"/>
    <dbReference type="OrthoDB" id="5982942at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF25">
        <property type="entry name" value="DUF4190 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
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    <sequence length="101" mass="11650" checksum="286364301AD88D0B" modified="2022-01-19" version="1">MDKGDVIEEVKPQKDYFVFSIVSFFFCPVFGILAIWKSSKTREKLRKGDDWYAELAAMDALKWALTAVAVGGAVYFMAILLVIYWLVRYYFGNDESPFIDL</sequence>
</entry>
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        <name evidence="12" type="primary">LOC110981856</name>
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        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
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            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="entry name" value="7tm_1"/>
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    <sequence length="363" mass="40715" checksum="6AA41EB6631BA5CA" modified="2022-01-19" version="1">METLPILQVGTEHNTTDGPLTENDLAGSIGSRNALGIVLSAIFLIIIICLSILGNVTVIIAIMKTPRLREKTSSIFLINLSATDLLNATLVMPGALVSLIADRWLLGMYWCYTQCALNYWFIIVSMLTLAMISIDGFYAVIHPLHYMNIITPKVTRLGICYAWFQGCVFALIPALYRWVVYDYWEVVCAIDWDSYRPNGALTYVIVAFILCFLVPSIVMTYCYTRICRVARQKAARREGGRPNARKHINDKRVIQSLVLIVVIFFLCMTPFCVTKLIKIFTSTSALPPYLYLASAWFGYLASATNPFVYAIFRRDFRQAFANLFCRGQIFPGLVPAAPDASNRQIDAQHRRQTVSPAAATSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUQ1</accession>
    <name>A0A8B7YUQ1_ACAPL</name>
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        <submittedName>
            <fullName evidence="9">Neurexin-1a-like isoform X1</fullName>
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        <name evidence="9" type="primary">LOC110982710</name>
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        <name type="scientific">Acanthaster planci</name>
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        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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            <begin position="938"/>
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    </feature>
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        <location>
            <begin position="1626"/>
            <end position="1713"/>
        </location>
    </feature>
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        <location>
            <begin position="1626"/>
            <end position="1651"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="1713" mass="188575" checksum="D16BAE10448B3625" modified="2022-01-19" version="1">MCVHVVATLHRDSRNFRCAWEKLFSLKDKLNDDQWHTVNYTKTPMEGDLLISVDSTTVGLSLYQTDAVIEWQQNLDSLSAVFFGGLNPSSSAMAPKDFHHLTGCMDSIYFLTDGMESWNHMNYTMQEGTVPGCVDLCASEMPCLNGRCINSYASTYCDCFESGYHGHKCEIPGNAMVTFQGFNYLEYDIFSSGNERPLEKNHINLSFKVGREQLVGTLLYASGVVPVQTYLTVSLKKGRLVVNVKLGSSLNTFQFEGQPAVNDDRWHYVTFIHNGKNLEVQLDGRSYHQEVADGTGLFHFGGPALIGGGQNLNGYPGLDEPANFVGCLREIYIDRYNVLEALYMNISGVRFHGGDPVKQCRPVGYPPITFPSHQSNLILDGWKNGSLNIMFDLKTDQGDGLVMLVLLDVDKKLEGRLRMELIDTALLLHLDIGTAPGQRLSRTTLKTSPGVNDTRWHRVALHLRDGVCSFVVDGRNLEFTYSHQLSASSSLYLGGGWRGQGTGIKGCVRHIVLQEKEIIATQVLGTAAANGVILDNCPVSNPCAAGEFVCQHGGTCSHASGGTRCNCEGTGYVGAMCSYSMYKESCTHLYHSGDQDSGVKVLDLDGPGPLNATYVNCTYRSGKAETTIEHNFAPRTLVRDVHLPSLEFNITYQYMTNEHLKQLVINSQTCRQYFSYWCFEAPLHVRRGWTALHSAAGRRLRYYNLPFVTHCDLNAKEWNVDQGIITNMPSLPIASMQFYKVQTYVHGTTKGTLSLGPLQCSSSLTEQRGRTVTISRSQDYITLKTWKSNSLSFKFRTSMENIVLFHQMGSGSDSHSLTGILKDAFSVWLILEINGDFYDGHVKSPRRLTDGNWHTLTVERSLIDFRVTVDFTEGFLNLPKGVTLMLAGPFLLGGMKELPKGTEGMTGCIADFTFNGDVVFLFDHFEHEEHLQIEAGCVTSCDSNPCQNGGTCVDRWSSYTCSCAHPAHSGPDCSRDNTKDVVSFTSEDLFLEFEAENADILTSDMQLGFRTLQSNALILYARDNLNNFVQMELVDDSTFGFTFNAGRDVHRVVVNANESVCPVPLSNPVLCAHLCQDDSHCNSGMKCCFTGCGTECVMPIGGGVLNDGEWVEVSVQRKDDMTVVNINQHQAEIGVPVNLLTEFYAQPFQDEEIIQPNQELRTSGKSMVHIIIGGAPNSLTLLPGLMGCVRGLIVNGQPVGLQEIVHIMRRLFSSKAPLLQCENHCSANPCKNGGICTEHWTSFSCNCSGTTYTGNTCEGESGAQFQDDSTLTVPLPMGTPLAGLQQDALEFGFSTNQPSGVLFYVRSDESSGAEERLMIALHGGDLEAHIDLGGGLTVLRVVGPFNDTYRHAVVFKRFGNRVLFDVDNIGFDYETLEPIEETEFNDRKLMIIGGVEVNQTDYGLRGLHGYEGCLTGLTYNGMQPFETLFTSNPERDRSNSVHRQQCSGFQSEEEGTTVTTTLMPRTESTEIFTMGLWDPQPVEGVKVDMPPELAANSAVNWVLIGAVSGGAAAVLLFLLCCCCILRTGKEEEAAEYEEKQQLVQPQDEVRVVHPVREEAAEAKCLDAPPEEPKDSPAPAHSPKLQEILRVDTCKGPVVVVAGDKLSSVDSLSDDAAFLQLEAEAGSPDKEVVNTKESLHEDDTLKAHKESAYLKSTTTEMETAQVAPIPVMTESEENLVEQLRAPSKPDADVAEDSTPAKQKTPESETDETCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW76</accession>
    <name>A0A8B7YW76_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110983021</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110983021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097569.1">
        <property type="nucleotide sequence ID" value="XM_022241877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW76"/>
    <dbReference type="GeneID" id="110983021"/>
    <dbReference type="KEGG" id="aplc:110983021"/>
    <dbReference type="OMA" id="THCADSA"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="3">
        <location>
            <begin position="60"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="3">
        <location>
            <begin position="241"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022097569.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="45905" checksum="6E87C15E40B1ACC3" modified="2022-01-19" version="1">MLSATDNVDILTLSDTHCADSAGNVVVSGGMYELGITTVTCSVTDAATNSGSCQFAIEVVDLEPPFMACSNPVPIATDIGRPDTAVTWTQLPSATDNVDMMTSSDIRCTNDAGFAMVSGGIYGVGTTTVTCSASDASMNTGSCQFIIEVVDRESPQISCPNAVTSESTDIGRADAAVSWTSMPSATDNVDVFTPRDILCLNEAGSAVISGGVYDLGITIVTCTATDAALNTDSCQFTVEVIDTEAPDISCPNSVISVIVDSGQSTVAVSWISMLSVSDNVDGLTLSDILCVGNAGNIVVSGGMYGLGTTTVTCSVTDAALNTGSCQFTVEVTENNNNGAIIAIAASSGVIVLGCLVAIASICVCLMRRVPGHGLYDVQNSFSNKNVEWEERPEGYRRSAKHDIRFHGQQNDIFPRPYIVPGPEFVRRTDENFNDAFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW81</accession>
    <name>A0A8B7YW81_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450 4F6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110983024</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097574.1">
        <property type="nucleotide sequence ID" value="XM_022241882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW81"/>
    <dbReference type="GeneID" id="110983024"/>
    <dbReference type="KEGG" id="aplc:110983024"/>
    <dbReference type="OMA" id="PVYNECV"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20659">
        <property type="entry name" value="CYP4B_4F-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022097574.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="57114" checksum="A25D274559AE1509" modified="2022-01-19" version="1">MLWVVASIIYAVTAFGLLKIALLFTGTLQLRHAVSKLPCPSGAHSLAGHQPQGPFDPGFQCLRDTVAAFPRVYTLWNGPIPMPTLVHPDTIKPLLTSRTGSVKSPLYQFFGDWLGDGLAISDGAKWKRHRRLLNGSFYFDVLRTYVPVYNECVDVLLSKMDRLAAEGKPMKVEHELGLCTFDIILRTACSRESNCQLKGQARDGDMDLLSATITMTDIVQSRMTGNPLFLNPLVFRLFSPNYPKWQKAARYAKMFGDGLIAERKDDLEKREQSGDPLTSPRDFLDTLLLARDKDGSGLTEREIADEVNTFLFGGHDTTSSTLTWVLYMMAKHPEHQARVREEIDKLLVDRDCDQLSSKDLGSLEYTTLVIKEVLRVYSTVVMPSRTLTAPYDVDGVTLPAGTTVAINLYQLHHNPTVWGEDHMEFNPSRFLPENMASLDPFAYLPFSAGPRNCIGQQFALNQLRVLTARILRRFCLSLVEGEPEPVPYLTVVVRPVREILLNLEPRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWF2</accession>
    <name>A0A8B7YWF2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">BRCA1-associated RING domain protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110982594</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096820.1">
        <property type="nucleotide sequence ID" value="XM_022241128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWF2"/>
    <dbReference type="GeneID" id="110982594"/>
    <dbReference type="KEGG" id="aplc:110982594"/>
    <dbReference type="OMA" id="LGQCEHV"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17734">
        <property type="entry name" value="BRCT_Bard1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17720">
        <property type="entry name" value="BRCT_Bard1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039503">
        <property type="entry name" value="BARD1_Znf-RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14835">
        <property type="entry name" value="zf-RING_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="562"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="595"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="628"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="696"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="10">
        <location>
            <begin position="815"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="492"/>
            <end position="506"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
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            <dbReference type="PROSITE" id="PS50172"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022096820.1"/>
        </source>
    </evidence>
    <sequence length="927" mass="100953" checksum="73FB2E151AC373F1" modified="2022-01-19" version="1">MEPCDWHCTREAVRKLEKSLGCGVCEKLLREPCTLGSCDHLFCRSCVGAHLGKTCPICHAPAWVRDLQLKRELASVVGLYAKLCSVINPEVSRGNKDEKVTVPTEQQVELEVRELANGDPKAFVAVEVDGTSRGVLRTRNTFPEPKTTETKVHKRRQFLSQGVGQKEGKKGSRTDGVDGLPFVVRENEKNRVPLASSSSSESDILDAMSVYDFVPSPQRPKPAAKKRARRQDAKVVKRQRVAAANLRWLRGDFAPRAASEESESGFDSERSARHVSFSVGTDQGQCLHQNSSSAELLSQDECPVDPTIPTPNSTQESGYATASNLDASNLADGDLPMKASSDAPLPNRCKNPDRKAYDRHLPGVRPTRQSPRQTQRDPQTVQASSSAPADTAPLTTASSKQRLNKRVHNKKAETSSSAEHTIKSLPLLTTDTGQRRHRSSPGTVPKTPEKDSPSHLKKRQGKDDAFTTDSSPPPQNIEAQNGGQSHKRSRRNANSSAENSLQTRSTRQTRKRSSAQSPSPKVSREPARKEAAAPSSSQNAHGLERPATSPRNGRAAVKRNKRGETPLHIAAIKGNLGTARQLLQDGADPNVKDNAGWTPLHEACNHGHASIVTVLLDHGALINTPGFEHDSPLHDAVMNYRLDVVKLLLERGASLEVRNMHGLTPADYTNSEPMRKALRTKPLITMDTNAMVTASQKSALARNQPVVLLGTGLKDAERKQLQACAKLLGGGRVVSEFGPAVTHLVASCNRDNLCMRTMKYLNAILAGVWIVSFNWAVECLKTKSRAAECKFEVKGTITLPSSSGAQKGRKNAEHQLPGLLDGCHFYLHSTFSPPTPSRAEIVQLIRNGGGTILSRQPKPDDDVVQASATIPYHARPGSELAACSYYIIHDHGGSRAPPRVRTGKLCTAPVSWLMDCISQFELLDLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYE6</accession>
    <name>A0A8B7YYE6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
            <ecNumber evidence="10">6.1.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glutamate--tRNA(Gln) ligase EARS2, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 22 23 24" type="primary">LOC110983090</name>
    </gene>
    <organism evidence="20 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22 23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Gln) + L-glutamate + ATP = L-glutamyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:64612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:64613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:23541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tRNA(Glx) + L-glutamate + ATP = L-glutamyl-tRNA(Glx) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9713"/>
            <dbReference type="Rhea" id="RHEA-COMP:9716"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:18398"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EC" id="6.1.1.24" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022097710.1">
        <property type="nucleotide sequence ID" value="XM_022242018.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097711.1">
        <property type="nucleotide sequence ID" value="XM_022242019.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097712.1">
        <property type="nucleotide sequence ID" value="XM_022242020.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097713.1">
        <property type="nucleotide sequence ID" value="XM_022242021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYE6"/>
    <dbReference type="GeneID" id="110983090"/>
    <dbReference type="KEGG" id="aplc:110983090"/>
    <dbReference type="CTD" id="124454"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050561">
        <property type="term" value="F:glutamate-tRNA(Gln) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 17 21" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="18">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="19">
        <location>
            <begin position="372"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022097710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022097711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022097712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022097713.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="59856" checksum="FCF3348DAC101A7A" modified="2022-01-19" version="1">MGILRLSLSRAVRQFTTSTFSGCEVRVRFAPSPTGQLHLGGLRTALYNYIFAKAHQGKFILRIEDTDQARLVTGAEEHLQNMLEWSGINPDEGPVQGGDVGPYRQSERLHIYKKHIESLVESGAAYHCFCTEQRLELLRKEAVRNRQVPRYDNKCRHIPQQEMQDLLHSGKPSVVRFKLEPDGESFEDLVYGKTSHDTFLIEGDPVLIKSDGYPTYHFANVVDDHVMGITHVLRGMEWLTSTPKHLSLYKALHWTPPKFAHLPLLLNKDGSKLSKRQGDIFVQHFKDAGFLPEALVNFITFCGSGFEENKEIRDMEQLIQEFSLDRVTTHSAVLEMRLLPDVNRGHITRLLARAEGRQRLVAQLRQDVEELLTRSGELGKIDDLTDEYLLRVLEARKQHVGRLQDLCQSDHIYLWLRPSLSKEELTSVSPHAELVLEQVCKEIGNLQEVALGEAGELSPKLRRCSESMAGIPYPVFMKVLRAALSNLKKGASVAEMIVMLGKREALYRLHVAKEISGQPVTDNRLATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ30</accession>
    <name>A0A8B7YZ30_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110983109</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097760.1">
        <property type="nucleotide sequence ID" value="XM_022242068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZ30"/>
    <dbReference type="GeneID" id="110983109"/>
    <dbReference type="KEGG" id="aplc:110983109"/>
    <dbReference type="OMA" id="HMARARM"/>
    <dbReference type="OrthoDB" id="6047381at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF1">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="14">
        <location>
            <begin position="980"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="423"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="692"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="937"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="575"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="709"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="836"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="876"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022097760.1"/>
        </source>
    </evidence>
    <sequence length="1177" mass="131144" checksum="C518F2B342F46C8E" modified="2022-01-19" version="1">MSSGKHDIKKKGRPKKLRSQVALPGPWRNSSWVNSFGGKGASPLKYQEVSPGFVLRQLLVLIEKGKFIDASQLVNKITMDALKDVVKDIPIESTIECIPQSLILLESLYSRLFISDADNFPVEQFQVEVMVFHIVRYLSMLQSSMEYKYPKPEDAKKSIMNILRIVLHVNPDLVRTLYKRKKLMDTALQGIGEHGLIEMNGSLVSLHDALKREIGRNITAYRGAVNTLEHLSFSRTKPISLALNGDKKSSHGHNHQALTKLNESQVKSRLFKNKALLNAIESSINSQLPALVATLKNRIEYDKSALLAFGKLKSEIKTFSSHTKVVPLLAQYSSSLHSVLNMFKELLDEHCVSDKSSYSTLGYHSDEEDMLSVQEAADDNVSPKPVEQPETEENTPKETPPADPIEQILNPLLGEQTSLDKLSLPGEEAPEKRSRWWNHHKRSRSVDVGGNRGGQRRRLSAGSESGVLRSRSRSADRIAISKPRRESVEESQEFQTMMTRIRDMSASSPAIGRRQLERRGISQPRSRDSSISPAALRKHFFGGGSQSPSMSSQTDLKDDLDPLYATIKPKSQRTKSSDKEASKDDKDLSQRLEDALKERDHLAEREKKLAKENDRLKDLLRLVTMEMEKMKEGRSESANDEVFLLSPDSVENGPRVAAELALVANPVEGFVVSSGAGSSVSDGVSPVLSEAIPVPEQFATPDPVASAESPDSPSEQVYILSTDQPNRSPPQSRKTASFVEQQKAVLREQAERLSQSFSKIHHQPPEELPESIVKQRKASFERQVQASQQEPSKSPPQVKRLANLDEKPDVPSLAAPQEQVSSDKQEEGRGDLETVKPSQNETIQVGSSSDDEQSPAPSAGTLQPDNEPREPVVKQESLTEPTSSMDYQEPAESPAPIDEPQPTAHKNAKSAVLFNQPHLAPIPETSSPVLHLKSASLVKQARSPDGSNNRPSKKVEQRKSKTTHTNRHLPKNIIRGVMDDLLYDYDKLYSEQRAVAWTGLTIPPEDKDALLFSVIVFAFQSAQTTIHELHMARARMLLIPTTDDEESVSSYTMDIRPDNRSQVELLEHLRKMGDSFDLNPMITDILERLYETSEHAPLLQSSAPLTKFVTSCVSLAWQLSIQSAPYVIDFELRSFDASLHQRAQGCNRKSARVKEHIWPSLLESSKGMCVYKGVVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ70</accession>
    <name>A0A8B7YZ70_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19 20" type="primary">LOC110983598</name>
    </gene>
    <organism evidence="17 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TMTC family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022098646.1">
        <property type="nucleotide sequence ID" value="XM_022242954.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098648.1">
        <property type="nucleotide sequence ID" value="XM_022242956.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098649.1">
        <property type="nucleotide sequence ID" value="XM_022242957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZ70"/>
    <dbReference type="GeneID" id="110983598"/>
    <dbReference type="KEGG" id="aplc:110983598"/>
    <dbReference type="CTD" id="84899"/>
    <dbReference type="OrthoDB" id="19588at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052346">
        <property type="entry name" value="O-mannosyl-transferase_TMTC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013618">
        <property type="entry name" value="TMTC_DUF1736"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44227:SF3">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE TMTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08409">
        <property type="entry name" value="TMTC_DUF1736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1736" evidence="16">
        <location>
            <begin position="351"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="573"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="607"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="709"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="743"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022098646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022098648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022098649.1"/>
        </source>
    </evidence>
    <sequence length="801" mass="90310" checksum="BD721B54402B9434" modified="2022-01-19" version="1">MTHQGSNHHRPASHNRIKAAPTGGGVRARRNGIHHHQQEKIDSQNNILKKSGEATLQSTNREWDCGIPIPELSLRSCTCLVAILSLFCYLNSCCGDFVFDDAEAVLSNKDIKPETPISELFQDDFWGERIVKNHSHKSYRPLTVLSFRLNYILSGGYHPFGFHLTNVILHSFISVFSLRIFSVIFSDAHSRLEAEKRQHQCQTFPAPRASLLCSLLFTVHPIHTESVAGIVGRADLLSTVFFFLSFYVYVAALQKDASHSLLKLSCSILCCAASMLCKEQGITALGVCIIYDIIVNCQVDILQVFQRFLIQTKSHAPGHPKWLPGLVTRLFVVSLCALVLLVGRFIIMGSGPPPFQPSDNPASFADGFLTRVTNYNFIYALNLWLLIFPHWLCFDWSMGCVSLIQSATDIRLLAPIALWVLLACLIYRCVVGQPSHNKRVLTMALAFLIIPFLPASNLFLRVGFVIAERVLYLPSLGFCMLLTLLINKISCSPVSKRAVRGLLVVLMACYIGRCIQRNQDWMTEEKLYKAGLDVCPQNAKVHYNIGKNAADRGNLEEAITYYRQALSLNPVYDQAMNNLANLLKDQGRLTEAEKLLQKAVQIKPQFAAAWMNLGIVQAVIKKYTDAEQSYKTALFHRPRYADCYFNLGNMYLELHRDNEALGAWLNATSFQSDHAQAWSNAVVHLESLGRYETAILVAKEAMKHVPQEPSIYFGLGNVLGKEGRYQEAEENFLKAIRLNPMMANYHGNLGVLYHRWGKFSEARKHYLSALELVPESDNVRENLKKLEQTMAKKKTKKHTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0U0</accession>
    <name>A0A8B7Z0U0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Low-density lipoprotein receptor-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110983445</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098395.1">
        <property type="nucleotide sequence ID" value="XM_022242703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983445"/>
    <dbReference type="KEGG" id="aplc:110983445"/>
    <dbReference type="OMA" id="CMDPGNT"/>
    <dbReference type="OrthoDB" id="21182at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000011">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1220.10">
        <property type="entry name" value="EGF-type module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034751966" evidence="17">
        <location>
            <begin position="30"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1671"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="14">
        <location>
            <begin position="492"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="14">
        <location>
            <begin position="535"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="14">
        <location>
            <begin position="578"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="1625"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1711"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1786"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1802"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="774"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="879"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="886"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="940"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="968"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1021"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1041"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1048"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1060"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1077"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1084"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1140"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1159"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1166"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1178"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1645"/>
            <end position="1654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022098395.1"/>
        </source>
    </evidence>
    <sequence length="1828" mass="202115" checksum="CD3CC79A8313811A" modified="2022-01-19" version="1">MAGPLFSGSWVPFVTRLLLLITCMYSAASQSCDFVCGGVCLTQLHVCDGYVDCVDGTASDERNCLVQTECQLDFEKCPTTSAGTNNACIHPQWRCDGDNDCGDFSDENRTFCQTTPCPSSMVKCSDTFRCLPGYAYCNGVENCYDGSDEPEECNNPDYTCPTDHFKCLNSRRCIPNVWICDTEDDCGDNSDEREDLHSCSTHACDSTRYFTCQRNRPGHSRCIPLDLLCDGTSHCEYAEDENITMCGTPEPCQFYEFTCDNNLCIPLWYQCDHDNDCGDGSDEGNTCIYPSCSTFQFTCNNGRCISISNQCDGFDHCRDNSDEENCECLEGQFQCFNKQCIDASSVCNGINDCVDSSDEGSSCNVNECLTTTCQYACVDEPLSYHCTCPDGYVLDTDQHSCVDRNECIETPWVCDQICINNAGGYTCSCAQGYTLSVDGYNCTLNSGIKPYLIFANRYYIRRLGVEVNSTDYQRLEQDFDLTVCLDYDYTGGKLYFSDVLTDSILKMDINGGNVETVLNHSVYGVEGLAVDWVTKKLYWTDHISDLMEVSELDGSNRLSIIRSGLFEPRGLALDPEHGYAYWADWGLRPYIGRVGMDGSSKMELHDERVGWPNGLSIDYPSGLIYWVDAHLDYVAYSDLNFERIHPLLHDDIRHTIAHPFSISVFNKDIYFTDWNLKKIFKANKYSGDEVELKSTVHRPFDIKVVHPLRQIPLNNICQSSPCQGLCLISPGGTSYTCACAENYVLSGVDCIPLCPEGQLACTREHKCIPWYMQCNGVNDCQSGEDEVNCPPRTCQPGQYQCQDGNCLTSILWLCDGDRDCPDNSDEGTVARCNTTACAAWQFKCRGTGRCISRRYNCDKISQCTDGSDEDDSLCRVHECSEGYFQCDNGFCIPEAWKCDLDDDCGDGSDEPHRECQNTPCPAGWFSCQTNYRCIPEYARCNTYDECRDNSDEVGCEAVTCDPLGEYRCDNHRCIPQRWVCDLDNDCGDFSDERPGCTPRLCSESEFRCVSRGLCIRDRWVCDGNPDCSDGSDESSCGAIICRPDQFKCTVGGCIAANLTCNGLYDCGDRSDELSCDCTTDQFRCDNTLCLPNSQLCDTYDDCGDGSDETPHACQIATCEPSTLVCIVDGLPKCLPEHKRCDGIQDCLANEDEAACDVVCSADTFKCQNGQCISWDRVCNLQSDCSDNSDETSCYKDTVECEASTCQKECITLSPTSIVCSCGRGFVETADGCEDIDECYLNNPCPQVCRNTKGSYECYCARGFVDRGIHGMDCKAEGDIEVILFGDGSELRKYVLEQNVYQDLVVNEARIESLDFDNHSGMVYFADTELRAIKRVPFTNDGAMEAPDNLGLDNVYAPVGITIDWLGNNVYFTDQGLPDAPRGRRAAADRGPKVAVAALKSHPYHEKTLHVATMPRAIAVNPRRGLMYWTDLGAPERGSRLFMSWMNGENKIPVQAATGKLDQPTGLSVDYAGNDTVFWCDARSDKIGFITYDGSHFVILQTSGSLNNPFQLDVFGNLIYWTTRWTDQRGMIRTMNKTGGEQAPFLSGLNLPTAVKVWQQHRYPLDVPNPCERNPCLYLCLVVPRQKGNAITKGFECACPSGVPVDPRHCEGSPVVPTATIPATSAVPVCLCLNGGYCKPDGSCQCPDNYEGKICATPSEHGGGPPNQNSSIGLVVGLVAFIFIAIIVIVILLFVFLKKRRKFAGPVTYRDGQNVDIHAPPPGREVEPPNHYETSLAPHAPVTFENPHYAHVAGAAGGGTVTLPQKTALPFDPSLYQPGYQAEALPEKAYLQDGSPALQAHYPEPPPAYSPNTPPPPSSEGNKEPDQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2D1</accession>
    <name>A0A8B7Z2D1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110984180</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:43816"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:43817"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:43818"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the taffazin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099774.1">
        <property type="nucleotide sequence ID" value="XM_022244082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2D1"/>
    <dbReference type="GeneID" id="110984180"/>
    <dbReference type="KEGG" id="aplc:110984180"/>
    <dbReference type="CTD" id="36405"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="64"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022099774.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31024" checksum="2CE2552E2BA00A7C" modified="2022-01-19" version="1">MPLEPWQFVIPEKPGTFWRIGSRFMIIGTGIISRIYLNWANHFQGHNLDILYNAVEKRPPERPLITVGNHISCFDPMLWGTLKMKGLGHPHKTRWCPIASDITCTKKWHVYFFSLGQGIPVVRGDGVYQHPMDVCIDKLHKGHWVHFFPEGKVNMNKEFMRLKWGVGRAIAESRVLPLVIPFWHLGMDEVLANHQPYIPKFGKKITMLIGKPLDFREALQHLREEARNQKEVDGYYPRRVCGFESQGRGSTQGQVYLQYLMKDFTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2H5</accession>
    <name>A0A8B7Z2H5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hexosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983866</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022099177.1">
        <property type="nucleotide sequence ID" value="XM_022243485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2H5"/>
    <dbReference type="GeneID" id="110983866"/>
    <dbReference type="KEGG" id="aplc:110983866"/>
    <dbReference type="OMA" id="KHRYSEC"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008499">
        <property type="term" value="F:N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF376">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022099177.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="51813" checksum="17D129E02B43D250" modified="2022-01-19" version="1">MVTADFITKRHFAAYEVSMSGEPDSTHAPGKGKVLVASSATVQPTDMSNGKGKKRRGRVPSFINPLTGRPTSLALAVIILAAVLIVYLMSRAKGGGSADSIDERAKNPKFQHILVPADDPRGLNVADEVNFPHVQRPNVAGQDEAVGKALAFPKIPPPPGRKPLPQAPDANRKKPELPRDPPPKPKEFPVNVIRKPNLLCPDKPYVLFLVVCLPNEVLARTAVRRTWGAPNGIAEAKSLALSWRAVFVMGRTAAKDDQIERESNNYGDILQGEFDDLSSEVTRKVMLGFQWSDKDIPDSCRPLYVFKTNIRVYINLPLIVPWIQDKLKMASNLYVGKMLREDRPIRDTQDPLYVPNQDYPGNVFPNLARGPLYMLSMDVVQRMVPHFGSVTPIAMEDAYVGVLANYVGAPITNDDHFVLLKKPKNFCHYRHMMFVFDIEPTELVHVYKVVEEKHRYSECTDRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2Y8</accession>
    <name>A0A8B7Z2Y8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110984280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022099989.1">
        <property type="nucleotide sequence ID" value="XM_022244297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2Y8"/>
    <dbReference type="GeneID" id="110984280"/>
    <dbReference type="KEGG" id="aplc:110984280"/>
    <dbReference type="OMA" id="INTTCAN"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034877763" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="24"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022099989.1"/>
        </source>
    </evidence>
    <sequence length="581" mass="62999" checksum="00DC63CF7A955C5A" modified="2022-01-19" version="1">MCTIIFVLLGYSFLFEGTKASEDHPVVTTSQGRIVGKRLEFSPFDPALRRSVDAYLGIPYAEAPVGPLRFKPPVAKSWSGELQATKLGNRCPQPPLPLGENITMAGSFDEDCLCVDVFVPQPGPPNSAVLVYIHGGSFMIGAGVAGGVYPIATAAVGNVIVVTLNYRLGALGFLSTNDDVIRGNMGLLDQRLAMEWVRDNIKAFGGDPTRVAIFGESAGAASLGLHMLSPGSRGLYRGAILESGNAAAPWATIQGSKARGRAFTLGKLVGCERQTSEDLLECLQQLEGFDKIIENQHEKSLSESGGGALPFVPVVDGEVIPADPKDLYEQGAINDAVSIIGANADEGMFFIKPFFPDNIYKAPFVDSYSFDVYVRCFLALIVSPELIVADAAKMMYINTTCANAPDCDYLQSLSQVLGDAMFVCPGVKTAKAFTKAGRKVYHYNMKYVATTTLMGNNWTKAMHGDDLIFIGGLPLYPSARWSFTDDEALMSIQTIKYWANLAKTGNPNLSSLTGEQGEEGKLPEWPLFTLEEMAYKDLSPSMGNGRGIKMRECLMWNEFIPKLVQIAEEAKTCYEAEDVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z367</accession>
    <name>A0A8B7Z367_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cilia- and flagella-associated protein HOATZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110983884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HOATZ family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099215.1">
        <property type="nucleotide sequence ID" value="XM_022243523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z367"/>
    <dbReference type="GeneID" id="110983884"/>
    <dbReference type="KEGG" id="aplc:110983884"/>
    <dbReference type="OMA" id="TVCSERQ"/>
    <dbReference type="OrthoDB" id="10004365at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040681">
        <property type="entry name" value="HOATZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47231:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN HOATZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47231">
        <property type="entry name" value="UPF0722 PROTEIN C11ORF88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17664">
        <property type="entry name" value="HOATZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022099215.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="19199" checksum="F4E9627673BB09E7" modified="2022-01-19" version="1">MAATITVTEPVCEQGGRTVFSGCSDEDRACAKLFWQSLTLQPPIESRLVSGDVRQRLKVAPPGRQPVNRAYEKIETSQKLVDFLERAQAEVIYAQSMKLTKQAIARQETLHILQKRKQERKEKEAISHRPAPPSLLDEEDDYDEATELEAVQAMAELDSFEQRIIEDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z441</accession>
    <name>A0A8B7Z441_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/arginine-rich splicing factor 7-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110984482</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100403.1">
        <property type="nucleotide sequence ID" value="XM_022244711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z441"/>
    <dbReference type="GeneID" id="110984482"/>
    <dbReference type="KEGG" id="aplc:110984482"/>
    <dbReference type="OMA" id="EMHRDSC"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001074">
        <property type="entry name" value="Splicing factor, arginine/serine-rich 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022100403.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="21220" checksum="0FCFF0EDF9494834" modified="2022-01-19" version="1">MSYFHRSVDCKVYVGNLGSGASRHELEDAFIKYGDLTNVWVARNPPGFAFVEFKNRSDALRAVDGLDDCYLCGRRITVEMSTGESRNRGSGRYPPRRSISDEKCYECGQRGHFARDCRYNRRRNRRSRSRSRSRSYSPRRHRSRSSSRNYRSRSRSRSRSRSYHSPPRRRSQSYDRDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z544</accession>
    <name>A0A8B7Z544_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Betaine--homocysteine S-methyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110984669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100759.1">
        <property type="nucleotide sequence ID" value="XM_022245067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z544"/>
    <dbReference type="GeneID" id="110984669"/>
    <dbReference type="KEGG" id="aplc:110984669"/>
    <dbReference type="OMA" id="KQAFPYD"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00083"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="BHMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF18">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022100759.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="39737" checksum="67FEC8A3192432A0" modified="2022-01-19" version="1">MPGKVKGLMERLRDGETVVIAEGYLYVFERRGYLKAGAFVPEVVVEYPHLVRQQYEEFYRAGSDVVLAFTYYAHREKLSLIDRERDLEKMNRTALRMAREVADQTGSLMAGNICNSNIYEPDNPDISAKIRDMFKDQIEWAVEEGADFILAETFSDFGEALLALEAVKEYGKGLPVIVNLAWHKKEVNGRPATIDGVEICETFKRLEAAGADVLGLNCARGPATMLPLIEEIQKCIKTPVAAIPVPYRTTEAEPNFQSLTDPLSGAPIFPLDMNPVQCNRSDIKEFGKRCMELGIQVVGICCGNDSYLTRTLCETLGRKVPASRYSADMSLHYLLGTSDKLSERHIRGEVRQHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6E3</accession>
    <name>A0A8B7Z6E3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Microsomal glutathione S-transferase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110984454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022100360.1">
        <property type="nucleotide sequence ID" value="XM_022244668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6E3"/>
    <dbReference type="GeneID" id="110984454"/>
    <dbReference type="KEGG" id="aplc:110984454"/>
    <dbReference type="OMA" id="HKYFWGY"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019370">
        <property type="term" value="P:leukotriene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000003">
        <property type="entry name" value="Leukotriene C4 synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001446">
        <property type="entry name" value="5_LipOase_AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF15">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00488">
        <property type="entry name" value="5LPOXGNASEAP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0434">Leukotriene biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022100360.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18090" checksum="E343A0134B4DDBD7" modified="2022-01-19" version="1">MSASTLSLLLRDEEMIFPAIVSLMHALQMAVMAKAVGGLRGKFKISPPATSGDPGFERGLRAQQNTLEFSPIFLILLWVSAKYLNPVLASLTALLYLKARSDYFSGYCASAEKRLRPFKRSVLIIQVLLLYSAIGLIHTALTAYFNINIPQKVGLDKYIPLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6S7</accession>
    <name>A0A8B7Z6S7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">ABC transporter G family member 21-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC110984613</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100660.1">
        <property type="nucleotide sequence ID" value="XM_022244968.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022244969.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100662.1">
        <property type="nucleotide sequence ID" value="XM_022244970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6S7"/>
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    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001276">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF63">
        <property type="entry name" value="EARLY GENE AT 23, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="559"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="8"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022100660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022100661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022100662.1"/>
        </source>
    </evidence>
    <sequence length="746" mass="84162" checksum="CA9A5161030870BC" modified="2022-01-19" version="1">MVKHGATLRFDNIHLSVKNSTILHDVSGKAEPGKLLALLGPSGSGKTTLLHVISGRVVTQNFGTVRLNDAPLTKAQRRKIALVLQDDIFFANLTLRETLLFTARLRLPSSMPYKAKIERVNEIVDTLDLNKCLDTRIGDYLHRGVSGGEKKRANIACELLTDPAVLILDEPTSGLDSTTSLQLVRNLKTYAEKTHKTVVMSIHQPSSQIFHLFDRLMLLAEGQVIYFGEANQALNYFASLGLHCEPNFNPADFLMDKAKGNEDEMSILFEAAKQKSWSVVRLTSRGSQTPDWRRPPQSDQSQLDHNDTPLDEYYHIGIRHHHSVPPTQRIRPVRHSSPNFSQITTSTGKSISFSRLPSINAPRPLSPKSLNQSPSPEHSSTRRPRATSQVSSSSDVGRRERRNTVVTISGVFGGYHSGVMSELSFPDSHRPPRFRLKPLRSRRVSTSSRNEESDASPKWPTTFFDQLHTLTQRNFKQSRDIFLSKFLIVKNVLLAVVVGLLWFQMSHDEVRINDIRGYFFFGLVYWGFESMFLVMNAFPAERTVVNKERLSGAYRLSAYYLAKMLSELPLTLIMPSIYFIITYWMAGLNANPQAFIASWCAMLVNVLVGESIGLAISAYAPSIQEAVVIVSVYMLTTLILGGFYIEQLPPWLEWTSYLSYTFYFFTLQMQFEFGLNGEPLKCREVNSVFEACHQSPNVTYVDSVEVLDQIKLLPLSLASICGIVVGFFVFFRLLGYIILRFIRTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6W4</accession>
    <name>A0A8B7Z6W4_ACAPL</name>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110983806</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110983806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099066.1">
        <property type="nucleotide sequence ID" value="XM_022243374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6W4"/>
    <dbReference type="GeneID" id="110983806"/>
    <dbReference type="KEGG" id="aplc:110983806"/>
    <dbReference type="OMA" id="DIRVCAF"/>
    <dbReference type="OrthoDB" id="88467at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034182641" evidence="5">
        <location>
            <begin position="22"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="260"/>
            <end position="314"/>
        </location>
    </feature>
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            <begin position="166"/>
            <end position="259"/>
        </location>
    </feature>
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            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="191"/>
            <end position="209"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="215"/>
            <end position="246"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022099066.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="32813" checksum="700D708B5A679859" modified="2022-01-19" version="1">MKIGALFAITLLVALIATSEARAMGSGRQVGDNKPAAECFKCPRPTRDIRVCAFDGVSYRTFPSRCMVDRKACKTGSSFTVVSDGACPLPTLPNPQVDEAGGDNKPAAECSKCPRPTRDIRVCAFDGVSYRTFPSRCMVDRNTCRTGSSFTIVSRVYCFGPDRQVFDREDDSDSDSEEIPENNDTDGGGSPITSAPVTPSTVPSQPPTTLRTVFASGTDTFSLPNGTTLPSGSLAPSMTAQTSSPAAGTPASGDPAASISVTSRPCNSFDSCAPSSSVCGTDGNTYPSQCVLEVTACVDNLDTLTVAYAGVCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAP7</accession>
    <name>A0A8B7ZAP7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC110985278 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7 8" type="primary">LOC110985278</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101888.1">
        <property type="nucleotide sequence ID" value="XM_022246196.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101889.1">
        <property type="nucleotide sequence ID" value="XM_022246197.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101890.1">
        <property type="nucleotide sequence ID" value="XM_022246198.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101891.1">
        <property type="nucleotide sequence ID" value="XM_022246199.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101892.1">
        <property type="nucleotide sequence ID" value="XM_022246200.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985278"/>
    <dbReference type="KEGG" id="aplc:110985278"/>
    <dbReference type="OMA" id="VWELWTL"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
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    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
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        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1336"/>
            <end position="1664"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="306"/>
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        </location>
    </feature>
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    </feature>
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        </location>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_022101892.1"/>
        </source>
    </evidence>
    <sequence length="3164" mass="364307" checksum="014DBE8EF4C87DEE" modified="2022-01-19" version="1">MRVMNELQQTASHPRGVCRRNSSIHGTMNPGPLWKQQHPKSSRRLLFKENMSPRSKTLGKVGIGRADRSKEPSRNKLPQVQENVSLQPTGNLTGNQKLVVSHTSKENNLSASRVRNLPMKGLRTHLSEVDFAKQIKHRAATMKDTVKRSVQNNVTCPSGNLLAKKSPAKEIIISLKGLGNISDIEMDHRPVPVDSHLISNNYRSERKVQDNMAYDRTFTDCREDEVTLVGMTDKLLAVVPALAGTGWNCFEADQSGLMNRQRGENSRLSKNFRLTVQDNVLCKLSVQNGEGSGSEPSNSILTTKLEENEESSGMEPAGSDSDQVSLAEESHTIEADNTAEAGSQDSGSQDSDEQELTRTPEQWLVEPLQRLSLGIGTDQSDCLQESKGILGTHSPGLLALDMSQFRARTGVPSRYPKECLPSVHREEESVMHSPVPLSDDPYFFTSPHHQPLQDDHTLHHGLNGLSIEATNLSHTGNHQFRQKLSFYATRGDHQFDSSTDSPHLDDQHWPDTAPITQPDSSGSALDENSETEPNFSTADYSDKWYSSAAPNGWVEVPVHSPTSLYSQITNPAKLLVEVTSVPQCNLDFYGSEPLSLYGHKFNSLPAEMEPYSVLESDKNQPTSRHVRNADTGDTDFNLPFTRATINSTHQFSSKRLAHPNTQSFGSLDISQPGDPDLRELDQLDDADLYRFSEADEFVHSNPTEGLYAQFTPRKGDENRRVRRTSKKPRTNETGKKLDEEKDAEEQDKDKDSQQLGTGKEPAKNWNNNNVATDEQYHSQVERHSMGYKHRVRQQNSSRSPHGYIAPSDNEHKVLLSSDRLAGGYSPELSANSSHNYQIATSLVGHPTRLTSRSILPSEGSGEAVHSSLLRERMDRSLQSSISLSPSTVTVDTAVLHTKLQYNLQSGGHLLLQSGMHDPTPDTKISPLRHSYPGSPGVGLTIDDLNLSVSPIDLKPRKFLNSSRSRVENQGRFPAVNKRRKDKNEIPTREHASGKSSLSEAVRSKQSKNYMYMYVDQSSSRTQHRNTESAQQRTKTKSNLQHLARVPKPLKSEGVPKKRHTMTASTAPESPLTLSSSTSPRRTFSILWAFKILDILHSAPPDMQEELVTKLYWFRRWHRNVRLIRVQKEERKEQWNRAVSHCRHRLLARCVRTWRLAPLSHKRAADHLRAVHLLRKGVHGLWWAVSQSRQEIEGAVERYEKRVKCRHFAVWRDLCQVRTERAQLLEKLAAKRSITVIFQTWKERYNFAQKDGIARLHYKVSLLTRGLQRWKLFTSQSKVRGYRDEMSRVHHEEMTVRKAWCTIKAVYAQTQKAHSHYSHKLLSAVLRTWVRGSQLAKAERHHQHSQALELRRCGLVRVHFKRWKEELFVMQLRKRLDTVRKRYVWDLWTLRLQRQQLYRQIMESQARKVAKQRIFTRWMQVARRQKEAAERAAAMLRRTYLQMVFGNWRSYVNKAQKLRSTLSAITSDVHLRSKQRTLQTWTSRLRDCLARQAAQRAWSKNCVLRAVSKWKERVRRRQMEERLEQFRPVHDEHMKRDAFRRWVREFRLALQDHQRALSAQHKLLRNQLLRLLLSWQLLVKESKTIAPLLERRDLKQLTNSFDAWREVVFRKRTCKKYQALQLSRSLGSAFKTWREQVVSRKELVSIQESLMASKLTRAFLGWKAAIQWQVSLKAFLRQRQEAMVRRIFEGWRKTAEEEMLLLEVEQGGKMRDVLLKTLLFKKWSKSTRQQKVIEASLVSDQRMRRRARTIRAAYKQWKRQFLVQIIARDAQADKDGRLLHRVFLAWHQETRSTYEQLTERFQLAYDAMSSSFPSDGVSPKSTLAALTLDLPQSLSSSSGGSQGLPAHLSTADSGYGNGLAPLQQEGHSCQETPRSQGGILDKGRSSGPQDENFQLETGRGQVPPPQLNRYRGALGATRDIVLSSDDDLYPDELPQQVGSPRFREQQHHLKPRRLLTQLSSSKFDTQPKSASGLQAPVSGHPISFLRRRASLDQNILSRPQADHRHPMNTTTSSGAWGSARSASMDQGLLSSPAVIRHLRNVHRKSQTENPMLFSWEEAPAVGSDSGVHDPPLSKSSSQTTSSQPQRLQTPKKHRSAQLQLSTSPSSHAFLPLQGSLSSPSHTPGSASPRSPDLSKSLSPLSPRSRMHFALSEGQSQTISDSRHSSISESSSTGPGSTHSSSYYMQLVGCDQSQSGTASEYAPSVFSDGAPPVSPRLDQRTYLRSIILHWRLWPASAAFNQWLDYVRYRKNLREISEQADWVFHQVRLRRALATWQRRCYVERLARNHWEMRTKAIHLMTWMQHSQDHKRCSRQKVAADSMACGKRLASAFHFWKTKYKKHKAVLSIVHNWKGYVQQTVDLEDRTKDLRHQIQRRTARECFRSWKLRTWQILEVKAHRNRVITKRCLVAWAVWSREATARREKLQSFQTRRIKLLVFHCWQSHLTKLQAARGFHHRATAARLRNIVRTWSTYIASKQQLEATAARMIHGREERMVVEAWKSWKRQVQRRQQMKQLYLTNLARRHLLAWHIHASRQQTLNVASAVAKDRRNTSLLQNSLQAWRRARCASQLACQMQARLGDKLIRKAFWDWRKYTRHCRCEKYGQMRLLKLALHKWRSRCVKQKSSRQTVLRVAHHWRKQAQRSKDLDQSLDSYLARRDAMKRRQALEAWMLAWQQQRRAVAHHSSVALGRCLSAWCTFASNRRQRQTALQLWQNNKCRKMLSASFEKWRKNHRRCLELETRMAGFHQQRAAELLAAVVRAWHHVTMEGVAVRRHNRAIQAKAWQHWQKALSNTQAAMQVAETRQTQVNHAIFRALRDWCRARRAQKELQHLVAARHRLHTLKAMFAQWKTEASKKSRAKAHADQVLQSKVLHKWAVVVQRNITLRVLSQTSQRACSRLRQKAAFWVWASQLRRTQLLRDRLEGALERRHQATLGRHFMEWRQTALASRAARHRDSVLLKQGWSVWRRRATERVLERQFEEDMGELADAHYNKHISKMVLSSWLTEARVGRLRRKRSRRLAKKYALIWKNGSRMAHTASALDVYSSMRKVWVVWRRRMIQSLMSKTMQQHSDRQLREQSFRAWRMQAAPANNGLRRDLLNWRLHAAFRVWRERTQGADNDQSCSSSLSNHSSSAGYTSSSGASELAGIWNNAQRGRMVGGEGGTAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBA9</accession>
    <name>A0A8B7ZBA9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985406</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102105.1">
        <property type="nucleotide sequence ID" value="XM_022246413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBA9"/>
    <dbReference type="GeneID" id="110985406"/>
    <dbReference type="KEGG" id="aplc:110985406"/>
    <dbReference type="OMA" id="WTEFRDK"/>
    <dbReference type="OrthoDB" id="427509at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF15">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102105.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46044" checksum="96D25DC70CD31B51" modified="2022-01-19" version="1">MVHSSDVYFIYNNEDEDFKAYLAKRLESDKLSVWSGLTSGEGLIDAKVVVIIMSSSSTLDKHCNDEVSLAYITDTPIFPVTRETFAELEPNLSFSLRLMVAKLNWMFFDSDEQKEANYPVLLSSIRSAVAMVNEETGEEQETQEEDEETPQAWKDRPNTAVVIREGKDFWEDKFGDTSEVPWIEFRDKFLEVYKDQMVEQFTEDKVQWLTNLLYGDVLLLRKVVTKHTYETFCRHKPNKPRDPDRFYNRLISYAKGCIAMRGVFNMESTVRLDAIQKLGQFKTQAVVSSLLDLSDEKDANVRAVAAISLGKTGIKSRRVSQRMIKLLSDEDRLVREAACISLGHMQIESAVPHLVNVWRTEIISHVRKAAEVALGLINSDRAREAIKMTEVLSREMKELSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCX0</accession>
    <name>A0A8B7ZCX0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Three-prime repair exonuclease 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110984808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022101031.1">
        <property type="nucleotide sequence ID" value="XM_022245339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCX0"/>
    <dbReference type="GeneID" id="110984808"/>
    <dbReference type="KEGG" id="aplc:110984808"/>
    <dbReference type="OrthoDB" id="10250935at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040393">
        <property type="entry name" value="TREX1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058:SF19">
        <property type="entry name" value="LD40940P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13058">
        <property type="entry name" value="THREE PRIME REPAIR EXONUCLEASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022101031.1"/>
        </source>
    </evidence>
    <sequence length="108" mass="12259" checksum="42FB59D75321A5A8" modified="2022-01-19" version="1">MSCDTKHHANIYLFDIETTGLGPHCKIIEICLHAVDRWSLEKCEANSQTPPRVVDKLALCVDPEMEISDKAEEMTGLSRELLQCNQRGAFREGVAKLIKSFLEIHFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZD12</accession>
    <name>A0A8B7ZD12_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Nucleoside diphosphate-linked moiety X motif 19-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13" type="primary">LOC110986190</name>
    </gene>
    <organism evidence="9 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103560.1">
        <property type="nucleotide sequence ID" value="XM_022247868.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103562.1">
        <property type="nucleotide sequence ID" value="XM_022247870.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103563.1">
        <property type="nucleotide sequence ID" value="XM_022247871.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103564.1">
        <property type="nucleotide sequence ID" value="XM_022247872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZD12"/>
    <dbReference type="GeneID" id="110986190"/>
    <dbReference type="KEGG" id="aplc:110986190"/>
    <dbReference type="CTD" id="390916"/>
    <dbReference type="OMA" id="GFMPSAH"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022103562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022103563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022103564.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45928" checksum="7D7682D9DED943DA" modified="2022-01-19" version="1">MKYWKEASTVILAARFRHQGPVTHPASSAASRMPAQQQDITTTGSLSKYFDYKVLMLQRTHRSSFFAGAQVFPGGGIDEADFSPRWMELFAEVGIRTPQDFGPMASIRHDRPPMIVENRDFPVPSDIAFRICAIRETFEESGILLVKHMSHCRAATESTPILQYHRKLTDTSDVSVETRKEWRHRVHQNAEDFLEMCREMKTLPDIWSLAEWSNWLTPSDARKRRYDTMFYLCCMDAQPSARQDGRETIQSEWVDPSQSLAQFSEGEFFLPPPQVYEFQRLCHFPELSALFNFSQKRALLGCQRYLPVRLNCSDGVLSVLPGDYLFPEQPMLETIVDESVPTLEGTIEENTDTSKPIHRQQFAMGTMPMCSSLSNFSLPHGHCTPLPYNQCVDFHNPNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDX1</accession>
    <name>A0A8B7ZDX1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melatonin receptor type 1C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110985900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103040.1">
        <property type="nucleotide sequence ID" value="XM_022247348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDX1"/>
    <dbReference type="GeneID" id="110985900"/>
    <dbReference type="KEGG" id="aplc:110985900"/>
    <dbReference type="OMA" id="ACLSMPW"/>
    <dbReference type="OrthoDB" id="9835842at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="60"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022103040.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40722" checksum="F1B8513421152910" modified="2022-01-19" version="1">MMIDEETPLQIPHFVVIIATDMEVNSTVIVYPGVTPAISVSERRFLATILCIIVVTGLFGNSVVMMSVFLSKKLRRCITTFFILNLSVADVAACLSMPWTIVSFLYPGGWPLPDFLCQMGGFGLIMFFGCSVMTLSTIAINRLHLITWTRHTYLTIYTPIKTGFIILATWLLAIMVASVPLIFNFGQLGYSARHASCTRDPSHPLATALNIFLAAVFYPVPCLIIISSYAKIYSFVRSHSRIIKHGHDPTKTSRTRAQIDRAHFRGHISRRQLLVTWNMFYVVCVFCALVSPYAIALFISNNDRALPYTAVVLSFNSCINPFIYATKHPDFKKVMVCILTCRIRNIPGRVRRQRTPAQPLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFX2</accession>
    <name>A0A8B7ZFX2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase RIO3</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC110986723</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022104552.1">
        <property type="nucleotide sequence ID" value="XM_022248860.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104553.1">
        <property type="nucleotide sequence ID" value="XM_022248861.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104554.1">
        <property type="nucleotide sequence ID" value="XM_022248862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFX2"/>
    <dbReference type="GeneID" id="110986723"/>
    <dbReference type="KEGG" id="aplc:110986723"/>
    <dbReference type="CTD" id="8780"/>
    <dbReference type="OMA" id="SKCPWGA"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000254">
        <property type="entry name" value="Serine/threonine-protein kinase RIO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017406">
        <property type="entry name" value="Ser/Thr_kinase_Rio3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038146">
        <property type="entry name" value="Ser/Thr_PK_RIO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="13">
        <location>
            <begin position="241"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="139"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="522"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="522"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022104552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022104553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022104554.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="61773" checksum="D6FAE77B118B5393" modified="2022-01-19" version="1">MSSTGKVVTPVPCVSPAPNPWKVAAPTRPACSLASVMDEEFAKKLQKDEEALTTKLDPGGQLQAQGPLTDYEYALSLDTSGGNAGTDSDLLLAQMLQLQFDQEHDAVLAVEEKKKNANSKVSISYANFRAVHPAIGKDENPAIYADSDSDDDDDDIWEYTEKGVSSPKKTPTTKDKNGTMTTKHDAVICGRKNASKVMEKFPPGFNSGDDVGMDMKLPNNVFNTLKQHSQTAERKTHRVHEKKEHSTAVMAMDPNTRLLLYKLVNNGILESVNGTISTGKEAVVLHANGGQHQRLLVPRECALKVFKTTLNEFRTRRRYLPDALSRMNPRKIIGMWADKERMNLNMMRKAGIRCPEVILLKKHLLVMSFIGEHQRAAPKLKDAQLSPEDMQLAYDQCTEMMEKMYKQCQLVHADLSEYNMMWFNREVWFIDVSQSVKPFHPEGLKFLLRDCTNVSNFFTHRGVPNVATPRELFNRITDLNLQDGSEQEFIAQIEVITEAEEFKALAPKEKNFAFDYFFEQTTAERSERERKESEGKEGEPDEEAEGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGB8</accession>
    <name>A0A8B7ZGB8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110986798</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022104698.1">
        <property type="nucleotide sequence ID" value="XM_022249006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGB8"/>
    <dbReference type="GeneID" id="110986798"/>
    <dbReference type="KEGG" id="aplc:110986798"/>
    <dbReference type="OMA" id="QCKYGYW"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000016">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="15">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022104698.1"/>
        </source>
    </evidence>
    <sequence length="958" mass="108665" checksum="F86B6C9C14BC167C" modified="2022-01-19" version="1">MSREETMVKGSMDIDDGYASKSGSGRVGMVVIAVVLTALAVAAVTVPVTYFFHPDYLKNQSPEPTQAPPTPTEAVDDYMRVNCHPGWEEGTEAECNRRGCRYSAPVADQGAPKCFFPKNYGGYRMVGKEAETPSGYRITLDRIPSTPTLFDADIGRLILDIEFQTEYRLRFKFYDPANKRFEVPLDMPQASGTKPARMMYHVAFTSDPFTLKITRKDTGTILWDTSLGPLIFSDQFLQITTTLPSSNLYGFGENEHPSFRHNIQWTSWGMFSRDQPPGGDANLYGVHPFYMSLEEDYKAHGVLLLNSNAMDVAFQPTPALTYHTIGGILDFYMFLGPTPENVVQQYTEAIGRPYMPPYWALGFQLCRYGYNSLDRVKEVVAGMRKYDIPLDIQYGDIDYMDRQMDFTIGQNYQGLGDFVDELKANGTHYIIILDPAIAANETAGSYPAYDEGVTGDVYIKGPDGESDLYGKVWPDLPGVVVDPNQDWDYQVKNYRAYAVFPDFRKQSTQDWWTNQILAFYNRVKFDGIWIDMNEPANFVEGSTEGCTDNKYDRPPYRPRIWGNLAEKTVCMNAMQHRTISEKTMHYNMHSLYGWSQSSPSLVANERATGKRGIVISRSTYPGSGKYVGHWLGDNTSKWPDMHKSIIGMLEFNLFGIPYIGADICGFFQDTTESLCRRWSLLGAFYPFARNHNGLNNIPQDPASFGEEFAKDVRDVLLIRYTLLPYLYTLFYEAHTMGSTVVRPLMHEFTSDSVTWDIDRQFLWGPALLISPVLDEGTEFVEVYVPEGPWYVYQTGTQVIRSYEKTTVSMYTPMDEINIHVRGGWILPTQEPANSTVYSRTNPFGLIVALDDSQKATGKLFWDDGETKGTIESGDYFIAKYIAGNRVLQSTITDPNPSLMADLVMDDIKIWGVKSLVSKVLYQNVELNSLRWNFNQANMVLTIENLNHPMTDNIILEWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHX4</accession>
    <name>A0A8B7ZHX4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110986677</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104465.1">
        <property type="nucleotide sequence ID" value="XM_022248773.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104466.1">
        <property type="nucleotide sequence ID" value="XM_022248774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHX4"/>
    <dbReference type="GeneID" id="110986677"/>
    <dbReference type="KEGG" id="aplc:110986677"/>
    <dbReference type="CTD" id="5191"/>
    <dbReference type="OMA" id="FAVHWNL"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044536">
        <property type="entry name" value="PEX7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="147"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022104465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022104466.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36172" checksum="0C7F5E413856FCCE" modified="2022-01-19" version="1">MFRPPVAFRSPGRQGYAVQFSPYLPQRLAVATSQHFGIAGKGSLFVIDVLPAGAVLLNSYEWNEGLFDLAWSECNKNIIVCGSGDGTVQIWDITQAKGPVKAFKEHTKEVYSVHWSQTRDQNFVVTGSWDKTAKLWDPNHHHSLATFTGHQHIVYSAIWSPYVPGCFASASGDHTLRLWDIKSPGAARMIIPATNCEIVTCDWCKYDQNLLLAGSVDSKICGFDLRNPKVPVFQLGGHTRALRRIKCSPHKKTVLASCSYDFTVRTWDFALQTTPLETIEHHTEFVCGLDFNLHIPGQLADCGWDDRTVVFTPKSLLENPVPGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIP6</accession>
    <name>A0A8B7ZIP6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-amylase</fullName>
            <ecNumber evidence="5">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110987206</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022105424.1">
        <property type="nucleotide sequence ID" value="XM_022249732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIP6"/>
    <dbReference type="GeneID" id="110987206"/>
    <dbReference type="KEGG" id="aplc:110987206"/>
    <dbReference type="OMA" id="TGACAIP"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034623468" description="alpha-amylase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="16">
        <location>
            <begin position="29"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="15">
        <location>
            <begin position="411"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="504"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="748"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="966"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="980"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022105424.1"/>
        </source>
    </evidence>
    <sequence length="1231" mass="135497" checksum="EA5EBF7AE27D1E85" modified="2022-01-19" version="1">MARLFLLLAALCTTTWAQYWNPHMEKGRHVMVNLMSWKWKDVAEECERYLGPNGFGGVQVSPPNEHAVLPNQPWWQRYLPVSYELQSRSGTEEELRDMVKRCNEAGVRIYANAVINHMANGEMAEGSAGNPYDPETLSFPKAPYTAQDFSVYNQKCPRKSGNIDDYKNEEEIRNCNLAGLPDLDTSIYHVRYTIAEYMNKLIDIGIAGFHVSNAENIWPNDLAAIYKKLRDLNEIFFEAGSRPFLFQEVDTTAANANIIKPIEYLEMGSVTEFEYGKIVSLALRGTENNLASLGSIEDKFSLVSSSGAVAFVDNADTQRSIPSIITYKEPRLYLLANAFMLAYPYGLARVMSSYDFTSFDEGPPSDLHGAILSPIINEDGSCGNGWVCEHRWTAVKNMIGFRNTSNGEPLVNWWSNNKQQVAFGRGDKAFIVLNNEDKSFSEFLYTGLPVGEYCDIIDGDFDLASRVCTGRVITVDELGFASFTQNNDGPPVAAIHINAKVSDEGTVNEPSKTPSAKTEGLIIAPPIPPSFPPSQNHTLDSASPESQNSATASTPQPTFKRTTVFIQKQTDFGQNLFIRGGLGEGCTGACAIPITHITTGNNAQYNAWKTGDNFLDWYGVEDGQNTYNNVSAEGTPLIWTTNNSSNTANVATDGYGYTPLNQWGANYWMVDLEMDCSKTNGGWFELKAFVMNGVEWESDVSQNEACQGSPGGNKPSNSINHFARCGYINVFKFGENKCTIDEYGLQPTQTIPEEPSLSQSPENSATEATSVPTASTPQPTFKRTTIFIQKQTDFGQNLFIRGGLGEGCTGACAIPITHITTGNNAQYNAWKTGDNFLDWYGVEDGQNTYNNVSAEGTPLIWTTNNSSNTANVATDGYGYTPLNQWGANYWMVDLEMDCSKTNGGWFELKAFVMNGVEWESDVSQNEACQGSPGGNKPSNSINHFARCGYINVFKFGRNECTIKGYSQGPSKAPPALETITPSPSQPLSTTSPTQSPSSDKSKDSKSENEAGSTAEPRVSGKTKFFTDVPKAPNTESTQKRTIIFLKKVTYTGQHVFIRGGIDHDHRSGCTTNVSTSACAIPIKHITPGENFRYDAWKTGDNYLDWYGAEKSQNSYQGTASQGTPLVWTTNNPSDTATLATNGYGYTSLNQWGDHYWMVELKVDCAKTEDGWFELKAFVLNGEGWESDISQSESCNGSAGGNKPFTSINHFARCGFINVFKFGEDECTIDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIT9</accession>
    <name>A0A8B7ZIT9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Inactive tyrosine-protein kinase transmembrane receptor ROR1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC110987221</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105459.1">
        <property type="nucleotide sequence ID" value="XM_022249767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIT9"/>
    <dbReference type="GeneID" id="110987221"/>
    <dbReference type="KEGG" id="aplc:110987221"/>
    <dbReference type="OrthoDB" id="2431000at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07459">
        <property type="entry name" value="CRD_TK_ROR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00108">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05048">
        <property type="entry name" value="PTKc_Ror"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000116">
        <property type="entry name" value="inactive tyrosine-protein kinase transmembrane receptor ROR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000139">
        <property type="entry name" value="inactive tyrosine-protein kinase transmembrane receptor ROR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018056">
        <property type="entry name" value="Kringle_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041775">
        <property type="entry name" value="Ror-like_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00018">
        <property type="entry name" value="KRINGLE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00021">
        <property type="entry name" value="KRINGLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3 16" id="KW-0420">Kringle</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034690698" evidence="19">
        <location>
            <begin position="33"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="662"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="57"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="21">
        <location>
            <begin position="166"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="317"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="21">
        <location>
            <begin position="430"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="22">
        <location>
            <begin position="570"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="725"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1026"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1030"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1047"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1073"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="867"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="732"/>
            <end position="739"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="806"/>
            <end position="812"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="871"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022105459.1"/>
        </source>
    </evidence>
    <sequence length="1095" mass="122270" checksum="5C08EDB69B6652C5" modified="2022-01-19" version="1">MFCGAGDGATRSLLRRFCVVVVLLCVWSTHDAASQGNVTPTSSTAVPLRTAPADGIPEIKVDEPMNNETVSVGDKVTLLCRIRGSPQPTYWWYHKDAYMMDDVGRVTIRTYPWGSKLMIKNVDTLDAGYYKCIAQNEAGSKETVGLVSILPGPFSEGSDSDYSVNLDNARCEPYRGSVCRRHITSSSVYMPMDASQEETEQELQAALTRLESLPSLTEACSRYILPSICLTAFPLCAETAPAELSVHRLCRDECQLLETDICAPLYDHVDSQVELDLVGVLPVCSDLPRLGSPDSQMCMRLGMSNSGDATVSPFQRPSGDYISLERDMNNQTELRTGDRAVLRCRITGVPEPRYTWYKNDVPISERGNRRITIRTYDWGSKLSIRNVDTTDTGYYLCVGDNRAGRRETTGILLAKRGDPPRTLGPGISVPTTGYCQPYRGMTCSNFIGNNSIYVTDYQAQGEVEKQLTSAFLVIMHDLSDRCQQFAIPSLCYFAFPFCDAEAAQPRGRELCRDECEILELDLCQQEYAIAKEYPGVTLPDCRRLPRIGTKESENCIRIGIPSVKAVSDVKCYNGSGIFYRGKVNHTKSGYECQPWEKQEPHSHYLLPAEYPELAGGHNYCRNPDNGLDKPWCFTMNPDVRAEKCDIPDCDDPLQEPTNKPEVLYIVVPAIAVLLFIAVILGCVIMWLRQQRTQRYANNKGLNNRPAEMVALQQKQQVRDFPLAAIKFQEVLGEGTFGKVYKGELMGLEHQYSVNSVTIKTLKENSAAKMEQDFNREAEVMASLRHPNIISLLGVCTTEQPHCMLFEFMPHGDLHEFLVRHSPNSDIGFGSGDDETQSSLDQSDFLSIAIQIASGMEYLSSRLFVHRDLAARNCMVGDNLQIKIADFGLSRDIYSADYYHMQAQVLLPIRWMAPEAVMFGRFSVESDIWSFGVVLWEIYSYGLQPFYGYNNQEVIEMIRTRHILPCPSGCPPHMYVLMTECWNEAPNLRPNFKAINARLRSWEALPTTNHQNGNLYTNPTVNFNPMCGPISPTQTHSSSGVKSQLSSHHSRSTHSKGSHGDRAAGSSEKAMSESSATTGGTHSTKGKKDRMEQTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIV3</accession>
    <name>A0A8B7ZIV3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110986926</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022104947.1">
        <property type="nucleotide sequence ID" value="XM_022249255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIV3"/>
    <dbReference type="GeneID" id="110986926"/>
    <dbReference type="KEGG" id="aplc:110986926"/>
    <dbReference type="OMA" id="VILVKCR"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022104947.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47867" checksum="96700465D4C13DAD" modified="2022-01-19" version="1">MCLRTYSLMRIFYTIVFVYIFIVGLLVGYSVIAPDARPSSSTLTTAQPTIPGILDLSEETSNKSDIPRKREESPPTYKEKVPNWDNITTVPLFSDEVINPHPFSFTIANRDACFRRNDTGDGIFLVILVKCRLNETYDRQQIRQTWGGVTQVLGQRTLTMFLVGQSTDPATNRKLRDEDNDHHDFIQEDFIDAYHNMTHKTIMGLKWVATFCPQASYVLSIDSDMTLNIYNLVVRLTQMPRTSFAEGNLRVDPRPHRKRESKWYTPYEMYPEPSYAPFLNGACYAMSGDVASSVYRESVHVRFLQWDDVFVGLVMKRLGVEPKLSPLYEQFLAVRVALRHGIGKGLRHNTYKVNEYVIKTWRNIVGKNLREQYETPTYVLALLLFNACFISAVFICCSIYIYTTADWEKTETLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJM7</accession>
    <name>A0A8B7ZJM7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Olfactory receptor 4M1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110987014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105085.1">
        <property type="nucleotide sequence ID" value="XM_022249393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJM7"/>
    <dbReference type="GeneID" id="110987014"/>
    <dbReference type="KEGG" id="aplc:110987014"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24230:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="25"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022105085.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="33500" checksum="654B375A6D85A55A" modified="2022-01-19" version="1">MEVSWLRRAPGITSSCLAILLGIPGNLLVVCVYRCKSTRTSTHVLICALAAADLLASLLIVFNPLFQRPQYLHEYSVVTKIHIALIDTLQLAGAFLLTGIAFDRYDAICRPHRRLLSIRRARALVGGCVGLWGVLTIITLVLVTPNSSPGDRRACSARLLVVISLPSTLWLCCFVTVVSLYAMVYKTVQKQGKVGASVVDQPRIPNAMTDEAKGDSDARHFGLTANSDAIPSSSLAGIWLNVMNCRGTPVPYGSAIVADVLMSFVMANNSANPFIYSLVNGNFRKSCLEILRKTRAKICRCFCRRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKK6</accession>
    <name>A0A8B7ZKK6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Selenium-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenium-binding protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105572.1">
        <property type="nucleotide sequence ID" value="XM_022249880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKK6"/>
    <dbReference type="GeneID" id="110987284"/>
    <dbReference type="KEGG" id="aplc:110987284"/>
    <dbReference type="CTD" id="8991"/>
    <dbReference type="OMA" id="AYDFWWH"/>
    <dbReference type="OrthoDB" id="10252446at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008826">
        <property type="entry name" value="Se-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23300:SF0">
        <property type="entry name" value="METHANETHIOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05694">
        <property type="entry name" value="SBP56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022105572.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="53769" checksum="F66A9BB79D42D5F8" modified="2022-01-19" version="1">MSTCCKGKGPGYKSPQEAMKGPKEEIVYLPCIYRNTEVKKPDYLATVDVDPRSSTYCKVIHRLPMPHMEDELHHSGWNTCSSCFGDENMKRNRLILPSLYSSRIYVIDVGTSPRKPRLHKVVEPEEVGSVAGLTNPHTTHCLANGQIMISAMGDAKRPGEGKGGFIILDGKEFSVVGHWEKEGHSSPFGYDFWYQPFHNVMISTEWGAPKAFLKGFDPADYANGLYGHTLHVYDWENHTLQQNIDMGDEGAIPLEIRFLHNPLATEGVVGCALSSNVFRFFKTSKGDWAAEKVIDVLPKKVEGWALPEMPGLITDILLSMDDRFVYFSNWFHGDIRQYDISDTRHPKLVGQIFLGGLICSDTPVKVTDDKELTKQPDPLYMNGKRINGGPQMIQLSLDGKRLYVTTSLYSGWDKQFYPEMCKTGSVMMQIDVNTDVGGLTLNKDFLVDFGDEPHGPALAHEIRYPGGDCTSDIFLASTANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZL55</accession>
    <name>A0A8B7ZL55_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAD52 motif-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105782.1">
        <property type="nucleotide sequence ID" value="XM_022250090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZL55"/>
    <dbReference type="GeneID" id="110987394"/>
    <dbReference type="KEGG" id="aplc:110987394"/>
    <dbReference type="OMA" id="PAYECRS"/>
    <dbReference type="OrthoDB" id="6287754at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057652">
        <property type="entry name" value="DSRM_RDM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040224">
        <property type="entry name" value="RDM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31164">
        <property type="entry name" value="RAD52 MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31164:SF1">
        <property type="entry name" value="RAD52 MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25517">
        <property type="entry name" value="DSRM_RDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="18"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022105782.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34068" checksum="C38BA5E30E27225C" modified="2022-01-19" version="1">MANLVDIIEFVRPHTKDKNLYVTGVSNRLPEEKVTAKLHQVFSQFGLLYEVQVLGSGSQPLTSDDRYLSEHGHVTVCSNFRQGLYAFVKYYSALAASRAVDAINGKYMLDGRLLKVRFANRQKPIENNAQLGFQQCCELANHHFGFNGWTSQIVALKEDKNCEANVARFIAVVRLDIRQHDMHSEGVGVGEVAFTTQDPMSRITAYLRAKKIAFQRASEGAFRKLIIVVLPNGKTAVEVNCTAIEAQHYVTQEELKGTVKVTQVEDPAEVNNPEVNSEVTDESQDTLDLDYVNVQLLVDLQMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNI7</accession>
    <name>A0A8B7ZNI7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cryptochrome DASH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988067</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May have a photoreceptor function.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
        <text evidence="7">Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5 7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106989.1">
        <property type="nucleotide sequence ID" value="XM_022251297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNI7"/>
    <dbReference type="GeneID" id="110988067"/>
    <dbReference type="KEGG" id="aplc:110988067"/>
    <dbReference type="OMA" id="KFWRCGP"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000719">
        <property type="term" value="P:photoreactive repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014133">
        <property type="entry name" value="Cry_DASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02765">
        <property type="entry name" value="crypto_DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF22">
        <property type="entry name" value="CRYPTOCHROME DASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00147">
        <property type="entry name" value="DNAPHOTLYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 5 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 5 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="9">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="388"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="6">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022106989.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="59734" checksum="7D68B775A690712D" modified="2022-01-19" version="1">MANKLRTVICLLRNDLRYHDNEVLHWANQNADYVLPLYCLDPRHYHGTWHFSFPKTGPHRLKFLLQSLQDLKETLQQVGSDLVISRGKPESVIQDLVRQLGKDNVKAVALQEEATREELDVEAAIAKSCQVPVQKFWGSTLYHRDDIPFRIRELPNVFTEFRKKTENQSRVRPTFPMPSRLNPLPPGIDPGLTPSMEDMGMAEPVKDDRSAFPYSGGERQALTRIQHYFWDYDYVATYKETRNGLIGADYSTKFSSWLALGCLSPRRIYEEIKKYEKERRANQSTYWVLFELLWRDYFKFVALKFGDRLFYLSGLLGNRREWRENKALFDAWREGQTGVPFVDANMRELAATGFMSNRGRQNVASFLTKDLKLDWRLGAEWFEHLLIDHDVCSNYGNWLYCAGVGNDPRQDRKFNMIKQGLDYDAQGDYVRLWVPELQGIKGGAVHTPWALSSSLLIQANVRLGHTYPMPIVKSPEWGKYTGSQERGKSGKGPGPRQQTRGLDFYFSSAKQRGHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNL0</accession>
    <name>A0A8B7ZNL0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110987756</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106485.1">
        <property type="nucleotide sequence ID" value="XM_022250793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNL0"/>
    <dbReference type="GeneID" id="110987756"/>
    <dbReference type="KEGG" id="aplc:110987756"/>
    <dbReference type="CTD" id="9493"/>
    <dbReference type="OMA" id="INPRIED"/>
    <dbReference type="OrthoDB" id="2403182at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01368">
        <property type="entry name" value="KISc_KIF23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4330">
        <property type="entry name" value="Kinesin-like protein Kif23, Arf6-interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032384">
        <property type="entry name" value="Kif23_Arf-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038105">
        <property type="entry name" value="Kif23_Arf-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF29">
        <property type="entry name" value="KINESIN FAMILY MEMBER 20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16540">
        <property type="entry name" value="MKLP1_Arf_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="21"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="601"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="688"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="805"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022106485.1"/>
        </source>
    </evidence>
    <sequence length="868" mass="99277" checksum="6E6AB942800B2E51" modified="2022-01-19" version="1">MKPSRGKTPKKPPRKAQNKDPVEVYCRLRPISDDLDSCVTIVNSNTIQLKPPEISLAVKNGNYKETKHTFKFVFPEQISQKALFDHVALPLVDDLLHGKNALLFMYGITSSGKTYTMQGTPGDGGILPRCLDVLFNSLGDLQARKYVFKPDRANGFDVQTEADAMMERQKKELLAPPPTPKSTPKTPRRYGLSQARKPPQNDIATMVRVPDTNRISTVDEDNNYSVYVSYIEIYNNYIYDLLEDTQSDGISQKQWQTPKSRDDNAISLQSKTLREDSNHNMYVANCTEIEAKNTEEAYGVFMKGQRRRKVAHTQLNTESSRSHSVFNIRLVQAPLDPVGEEVLQDKEQVCVAQLSLVDLAGSERTGRTQNSGDRLREAGNINASLMTLRTCIEVLRENQMSNTNKIVPYRDSKVTHLFKNYFDGEGKVRMVVCVNPQAADYDETTHVMRFAEVTQEVQVARPTAIKFDIGLTPGRRRANQIYKKMLEDGADLENLPIQTPVIINLGPAFPCLEVNDPNEDSILQNLITFLAEREKRRHTLQEELTRKQGAFRARLMEMEREMETLKQQNSELNMKVSSKDKNTQRFEKRIRDLEQENEMMKKTQTAYEYSQRELETELREEKSKTQKQKHEQDRLRQALKGVAGSEKVKWEKECEKRVRATQMEMQTKIWVKDEKLRQLKQIVCAQQEREDKARKAKADLNRTRSPPPKTTQPPVKLRHRRSRSTSNAWIDHKPATTLETETVLQPAGLKKKHTVAVPTVKDLKGTDNYMLTHQEEDSKGELETKLYKAEVLQTRGGGRAVQFTDIEKLKTERPASTSPKDRKRPAEEELESGEWTDVETRCTVGYEGRPGNVEPAAVHIVPSKKMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNW5</accession>
    <name>A0A8B7ZNW5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Merozoite surface protein CMZ-8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106590.1">
        <property type="nucleotide sequence ID" value="XM_022250898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNW5"/>
    <dbReference type="GeneID" id="110987805"/>
    <dbReference type="KEGG" id="aplc:110987805"/>
    <dbReference type="OMA" id="HRAMARN"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106590.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17377" checksum="C15A627741DDFB0D" modified="2022-01-19" version="1">MTRSRVKERDPLQEGGIVSITYKSGIYKARIVGGQAQKRPRLSSDDDDSLINSVKDQLVSPPASPERPISPPASPKHPAQPPSSPVCPVLPPASLVHQDPSRFSPEHSFSPHASPKRPAQPLSLPVHLVLPAASPECQVLPRSSLECPILCIHQRSVFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP57</accession>
    <name>A0A8B7ZP57_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Neuronal acetylcholine receptor subunit alpha-10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110987064</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105176.1">
        <property type="nucleotide sequence ID" value="XM_022249484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP57"/>
    <dbReference type="GeneID" id="110987064"/>
    <dbReference type="KEGG" id="aplc:110987064"/>
    <dbReference type="OMA" id="FSSWAFD"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000043">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034204673" evidence="16">
        <location>
            <begin position="26"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="33"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="245"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022105176.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58028" checksum="E159D7BCF8F358B5" modified="2022-01-19" version="1">MACRVRPLAVFLLALCVTFPAGSVGKKSTQSILLEKLLSEYGPSTIRPVYNISRKTTVIHRLLITQVIELNEKHQTIQISGWLRQTWEDEFLKWDPADYEEVDELYVHQSKVWLPDTTLYKNVDKDFESYKDISVQVFSSGEVRWATPVILKCTCLIDARLFPFDTQVCELKFSSWAFDGSEVDLVKEEGLEAGQVHFADNGVWQLLRVEVVRQEQWYACCPAPYPEVSYYLHLRRRPLFHVLNILVPCVLLSVLNLMVFSLPPESGEKIQLGMTNLLALVLFQQLISESLPPTSDKSPVIGFYFTPMIAIGCSSIVCTVLVLSLFYHDNSRPVPRWLRYVALKMATVVFYRVKVQPPPLDDRGGTSNPSYSLEGEVTGQRFQDSDSGVLTATCSFTDSSRSVNSEEAFGAGAADDGASLDAGQRKANMRCRATAYSMHFTQKVYSANGGEAAPANEAKETADTPQAKAEIACSGGNQTVDWKDVALIIDRGTMILSLIVTFAAMLITVLFFLLPNSHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQF6</accession>
    <name>A0A8B7ZQF6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Carnitine O-palmitoyltransferase 2, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110988522</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4,8-dimethylnonanoyl-CoA + (R)-carnitine = O-4,8-dimethylnonanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:44860"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77061"/>
            <dbReference type="ChEBI" id="CHEBI:84654"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107813.1">
        <property type="nucleotide sequence ID" value="XM_022252121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQF6"/>
    <dbReference type="GeneID" id="110988522"/>
    <dbReference type="KEGG" id="aplc:110988522"/>
    <dbReference type="CTD" id="1376"/>
    <dbReference type="OMA" id="HILVMRR"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000001">
        <property type="entry name" value="carnitine O-palmitoyltransferase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.20">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042572">
        <property type="entry name" value="Carn_acyl_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF16">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="11">
        <location>
            <begin position="71"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022107813.1"/>
        </source>
    </evidence>
    <sequence length="681" mass="76803" checksum="F63398A116D2A640" modified="2022-01-19" version="1">MAGICKFRSTIDISKKHCRHVFLKRLKMHLPLASCVMESHGVRYLSSGPDPDFLHESIIPTMHFQRSLPRLPIPKLVDTCRRYLASQKPLLTEDQFAHTKAMVESFRHNEGPDLDMLLRIEDKQNKHTNYISGAWFDMYLKDRQSIVLNYNPFITYNNDPRPENMDQLIRATNMVISAARLMKTMRANVLEPELFHLNPKKTDTDSFKRMASRMPESIASYYAILNKAFPLDMSQYFRLFNSSRVPLYGRDDFATDPTAKQVLAIRNGNFYTFDILDKDGNILPPSVIHANISYILQDGAPPPEHPLGFLTSENRNTWARLRQHMAGLSASNAESLRRIDTAMLCLCLDDVSPDTPESMTRHMLHGNGSNRWYDKSIQVILCKNGMMGVNFEHAWGDGVAVLRFFNEVYKDNSEKPAVGPDSQPANVDAAENVQSIRFDLDVAMKDSIQKARDGFHAMTSRLGVCAKQNFLFGRDYLKSTEISPDSLMQLSFQIGFYTLTGQTAPTYESCSTAAFKHGRTETLRPATMETKQCAMAFQKDSGVSAQEKRALLKACSDKHYGLTKEALMGKGWDRHLFGLRKLAERDFALPEMFTDPAYANINHIILSTSTLASPAVLIGGFAPVTPNGFGIGYGMNSNNLGVNITSYPESHSVDDFVECINRSWEDMYEVLSTTTAPPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQY1</accession>
    <name>A0A8B7ZQY1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Centromere protein T-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12 13" type="primary">LOC110988255</name>
    </gene>
    <organism evidence="8 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-T/CNN1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107282.1">
        <property type="nucleotide sequence ID" value="XM_022251590.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107283.1">
        <property type="nucleotide sequence ID" value="XM_022251591.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107284.1">
        <property type="nucleotide sequence ID" value="XM_022251592.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107285.1">
        <property type="nucleotide sequence ID" value="XM_022251593.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107286.1">
        <property type="nucleotide sequence ID" value="XM_022251594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQY1"/>
    <dbReference type="GeneID" id="110988255"/>
    <dbReference type="KEGG" id="aplc:110988255"/>
    <dbReference type="OMA" id="AYCKHAG"/>
    <dbReference type="OrthoDB" id="10071342at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028255">
        <property type="entry name" value="CENP-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46904:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="7">
        <location>
            <begin position="471"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022107282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022107283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022107285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022107286.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="62552" checksum="219B7C8EEE89A8E5" modified="2022-01-19" version="1">MATDDVTPRTLIQGFIEASSVSKSAASTSRVRVRRSNTGNRVAALRKDDKMRAQSISDLTPRSLIQGVIQNNEVEEPPPSKKPRKSPPETEHPPAKTPGTLPHSTARKRVTRLEALATPGGNPTPRSLIQGLVGTAPVETPAVHVRRSSSLNPTDFPDVEEALQGRANKESLSPLVPEPTDTTNQSQPPATNARKRQQVSSEDFATGIQERLVQRQGGDTEEEEEEAGEVGDVTETEDVQESISEDAGDGSQELAESEENLQDTQGDIDDKEDEAKEQETADVPDDAGEPQDESIREEEAHPDSAISTASTPSTTPASQATPPADRTSPESTSKQAADSTWTGREPEASIPSQREGSPGGTRRVPDSTVLDPSSEGGEAVPPDQPTEEESSIAEDSEAQQTTGGGESSRLSGFSPLVTPRLPSGSGRPTPALKKTPAHRQEAAQREEPSSEVQKQGPKKKKQPPMAPRKEAACLPTSLTRSILSHFSKARVSKEAVAAVEKGVETFFKRLSNDLTAYSRHAHRQTIEQSDVELLMRRQGLIRDQQSMYALIEKYLPMEYRQELIPMATAGNKVTPKPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTL5</accession>
    <name>A0A8B7ZTL5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR and ankyrin repeat-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108918.1">
        <property type="nucleotide sequence ID" value="XM_022253226.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989099"/>
    <dbReference type="KEGG" id="aplc:110989099"/>
    <dbReference type="OMA" id="KYFEFFC"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09275">
        <property type="entry name" value="RNase_HI_RT_DIRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1227"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1419"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108918.1"/>
        </source>
    </evidence>
    <sequence length="1434" mass="162627" checksum="02A6F531BB8E3AD8" modified="2022-01-19" version="1">MGFHRSHISILELQAVFNALKAFHPSIIGKRVLICSDNSTVVSYINRQGGTHSPRLCLLTRQIFLWAKDYGIDLQATHIPGVDNSMADALSQGKVLNSELKRLYTAITRARVNIWIFDEDETKRGPMFELFQCLRLVKGIGPDTKQDDEDSKVDSMFAEKSSTVEWVQQGHYFFENKLWKMAAKCYQHGGDEKNELLARAHHQAVEAEHMRDKGHAMREKFLLAASLFLKCGSSSMAVNCLYNAREFALLAQLLEKQGKFSKAAKIYEKRLNCVSDACRCLVLMKDYAKALDLLCSVGLHTKALKVISQFKRFEQELKQKGKPLPRHVKPPESIHTLSELMFKSAEYHCRNEALDKMLDALKQLEKFEARVDFLRNRGLLEEAVKMLKDAGRPLDAAKIRREQGKLKEACTILESSNHPEFVAECRLSQARKLVLELDNTDGQTTAISLLTEAESLFARCSDSFGKSETQLLLGQLKKETTKIREAKNAFNRMSHTAAESECTYQLIKISRQYAAPVPPLKKLLELICAMLACENPEEKRQRQLCEEFFGLAPVEDGKLHIQKCEGARVLSALDKSLSQANDVEAWKAREAIAKCCLIPRALEWVKGARDHLHEQVKKLTQCSDYVIGMPCSKSAGTCKELHEPYKLYQLEGQIHCLVQLIQINDIIQKASKLSSFESTCELMKEIKHSQEESAMNCKALYEVFFPKHCHQRLIGDTAQTTQKLLKLLQNPEIKSQLKAFIENKRKKADPKSVRAGTDLYLMCHGIYLLIGEGTEVIENWVTQEECYCLKWQQREGWNQSQPLGMRLLNNEEPLKRFLSYKRYHLNSFESLFKSRDAMESLSSFNRFMGTLANKPRAPLLPSISNTVAMIEAKVTMMLALGAKIQQCTVAIPASYLAQAGFQDAVCCPGQGHAMYSAVSNSAVNKHTPGQTCRLVSLICGTTRSGRDFNVLADAFSSVEYIQTGEAERTLVVVLVMLCSAGLALPAKIIRVIREALQSITPSEQHLPKRVHTALCNINKAQSRHDALQVLEKLLTAREKEYLRECTWNTHMPPLGAPGLEFRKLNIKLFKNMQFEPLDALMTPTVLTELAEGNFCQRGRDFKRKDEGVAREGEGCGDDSEEEGELCLEVSKEEAAKVQRKQETMQREGAAKVIMRVLKASRLLRLAGLLRSRGHTTISVKPEVEVQLETTADSWVSSQLFDFQPIPSQCTICSENLQLVQEARFELNDPDEGGQDRTAAAGEGDSVETDHELQPEALSKDLLTQEEHEATESHKQRHQEFLEYKCLLRDKVYPLVTEVDKFLQELHSPCQAGEKSEDWNNFTYFKENLSTYKKELTDKMAEMQRERAFGRLSEIRHAVQQLEMEYETSKRKWEQRAAKQQDSWDSDVELADTMTFEEEADEKVLPVPNRQKGGQSKFTGSRKKRKHGKGRGRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTQ4</accession>
    <name>A0A8B7ZTQ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein LOC110989035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC110989035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108804.1">
        <property type="nucleotide sequence ID" value="XM_022253112.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108806.1">
        <property type="nucleotide sequence ID" value="XM_022253114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTQ4"/>
    <dbReference type="GeneID" id="110989035"/>
    <dbReference type="KEGG" id="aplc:110989035"/>
    <dbReference type="OMA" id="GVEIWFE"/>
    <dbReference type="OrthoDB" id="10031677at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022108804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108806.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34170" checksum="F1129719F5662918" modified="2022-01-19" version="1">MTDPVRVIMWSVPRSCSSIVAKCMDRVPDSKILFQLYTGAYWDGLGQFNPPKVSSPVEELHNAVVGTDSSHHPDEKSTYPWVKRQLEAHYPGKRFVFAKEMAYCIDGKFEYLPEGYRHIFLIRNPVKVFQSFKRILPEIMAVEGQQMLGMGGGEFEVDKLPPHLVPPGFSFKEAVNLYEYLREKTIEAEPIILDSDDLMNNPATLLSEALKRLGVQYQDAMLTWEKGMGVTDNWVIGQGVKKRIGHVSSFKNFRDSTGFFKSKAVAGALQPIDSLAADVKRCVEFSMPYYTRLYERRLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUN1</accession>
    <name>A0A8B7ZUN1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-sulphoglucosamine sulphohydrolase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110989034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108802.1">
        <property type="nucleotide sequence ID" value="XM_022253110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUN1"/>
    <dbReference type="GeneID" id="110989034"/>
    <dbReference type="KEGG" id="aplc:110989034"/>
    <dbReference type="CTD" id="6448"/>
    <dbReference type="OMA" id="MAYPMRM"/>
    <dbReference type="OrthoDB" id="10012954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016250">
        <property type="term" value="F:N-sulfoglucosamine sulfohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006027">
        <property type="term" value="P:glycosaminoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030200">
        <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16027">
        <property type="entry name" value="SGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000026">
        <property type="entry name" value="N-sulphoglucosamine sulphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022108802.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="58135" checksum="1EF245A4A5997023" modified="2022-01-19" version="1">MAVVGKGCVFCSAIVTLFLYVTGVQSQLKKNVLLFVGDDAGFETQAYNNTVCKTPHLDVLAGRSVIFRHAFTSVSSCSPSRSAILTGLPQHQNGMYGLENSVHHFVSFAGVRSLPTILKQSGIRTGIIGKKHVGPESVYQFDYSKTELDGFSILQVGRNITHMKQFAHEFLSSNDSGPFFLYIGFHDPHRCGHTHPQYGQFCEKFGNGAPGMGRIPDWEPTTYDPGEVIVPGFVQDTPAARGDLAAQYTTISRLDQGIGLILKELESAGHKDDTLVFYTSDNGIPFPNGRTNLYDSGMAEPLLVSSPLHRERWGQESEALVSTLDLVPTILDWFGISYPDYHLNRQPVRPTGRSLLPILAQEPVTEWDTVYASHNLHEVTMYYPMRVVRNRQYKLIHNMNNLAPFNIDQDFYISSTFQDLLSRTRSGEPTHWFKTLKDYYYRPQWELFDHRADPLETTNLAKDKRFASVLRDLREQVLRWQNVTNDPWICAPWGVLENAGLYKQNPTCMPMDNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUZ3</accession>
    <name>A0A8B7ZUZ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Farnesylcysteine lyase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110989094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108912.1">
        <property type="nucleotide sequence ID" value="XM_022253220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUZ3"/>
    <dbReference type="GeneID" id="110989094"/>
    <dbReference type="KEGG" id="aplc:110989094"/>
    <dbReference type="OMA" id="FEVWYSQ"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF0">
        <property type="entry name" value="PRENYLCYSTEINE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Prenylcysteine lyase" evidence="8">
        <location>
            <begin position="183"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022108912.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="56156" checksum="E7BF011BC36B0CCC" modified="2022-01-19" version="1">MYTNLRREFFPMPRCIGDKNAASRPSASLALVELCCSQSSEMAVYFRRLKQSRSLHGHTLVVETDSTMSGSPHVVIVGAGMGGATCAYYLRKELPGVTVTVLEARDRVGGRTKDITFWGSTVNMGAALFNTEQRNIAALAKELNLKIHCFKRSGDFPDNTIWDGREIVQTGKLLSIEPEADAKMRQSLKEFLSALEATYQKYDNGTFRSIPEFLAAGGLEAYTRQSVEEFFCDTPVSKRVQKYVIETVMREFFGQGLESSVALAMICLAGVYQDAFKTEGGMSQLVKTLIESSGCNLHLNSSVSLVRKMEDQFEVWYSQREAEPKLKISADTIVIASPLEWAGIEFEGFIPAIVQPKREWERVYMYVSKVAAKSIRKSYFKGVSLSPDNPSCIYTTSDASQPWVALRSRDSSEGYNSYSIFHSEDIAEEGFLDQLFEGVRDFKSERWDYVHPVCPPVRGSDGYQSIILADGLYYLNGLESVASQMEIAVVSGRNIARLISKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZW08</accession>
    <name>A0A8B7ZW08_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C3/C5 convertase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110989117</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108955.1">
        <property type="nucleotide sequence ID" value="XM_022253263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZW08"/>
    <dbReference type="GeneID" id="110989117"/>
    <dbReference type="KEGG" id="aplc:110989117"/>
    <dbReference type="OMA" id="CIDITIR"/>
    <dbReference type="OrthoDB" id="6127264at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393:SF7">
        <property type="entry name" value="COMPLEMENT C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46393">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 14" id="KW-0768">Sushi</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034205417" description="C3/C5 convertase" evidence="15">
        <location>
            <begin position="26"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="19">
        <location>
            <begin position="190"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="19">
        <location>
            <begin position="244"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="348"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="549"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022108955.1"/>
        </source>
    </evidence>
    <sequence length="825" mass="91096" checksum="B442019321F24AFE" modified="2022-01-19" version="1">MAGTGLATRLVVGVVLLVGISKACGGTIDRQRPSKSGACLLSKPLENGYYIDITAGERRLRGRRVKPNHVIEARCEPGYGRRGAKLRRCDDSTMTFDRRAPVCEDIDECFYAGLLGSNDENDSWEPSEESSSNSESSLFDPLLVVDLSLLPAVNCHSLGRCVNTPGSFRCQCNRGFEGDGIHSCQKIVEKACEQLQPPSHGSMTGDPTRLVHFSCDEGYRIYGADTRRCMNGKWTGLRPICEVVGCGDPGTPAHGFKVGRNYDINGTVSFFCDEGYELVGHKSRICLDGGDDPWSKHFWSGVQPVCRTVAQSVADIAQNIQTDFVDRLEVFTHSGRGRLAVSDNIGLDLVFAYDTSSSLNRVNFQRGINFTESLLKQFGVSYEKGGTRVAVVSFADRANIEFTYGSDVDTFEKVMEKITLLKDNLGGGTALRGALERVLALSQDMRNESKKALFLMTDGEATVGKDPAAIAESLRRDYGMEIFLVAVGQSIDHRQLRKIASQPYSTHVFLLENFEDLEQLTAIISEKGAEYKRCGQAGNLELPYSSGRQVGKKDANPRAWPWLVQIVALTEDGPFLQCGGALLCEDWVVTAGSCVWNETGLRAFPAEYFLVRLGSHELGIQEDTQQYGVAEVRLHEDFFIYNRDNDVALLKLNQSVNLTSAVRTLCIPSEIEVIRLRSSSQCYIAGWGIVDPIRDVGNNDSIPPVFPQQHIIPLVNDNDCREEMHEMPFPIDKKKLCAGTRYQAPHGACRGDTGAALVCKQIDESWAVTGIASYTNDCTEANKFAVFTRISEFIPWLHRQTANCTMKYEVQSVGGFQEQALQNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX33</accession>
    <name>A0A8B7ZX33_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110988665</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108101.1">
        <property type="nucleotide sequence ID" value="XM_022252409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX33"/>
    <dbReference type="GeneID" id="110988665"/>
    <dbReference type="KEGG" id="aplc:110988665"/>
    <dbReference type="CTD" id="6632"/>
    <dbReference type="OMA" id="TFLMKLT"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000016">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 14" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022108101.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13115" checksum="860FE3922538B898" modified="2022-01-19" version="1">MKLVRFLMKLSHETVTIELKNGTQVHGTVTGVDVSMNTHLKSVKMTIKNRDPVQLDTLSIRGNNIRYFILPESLPLDTLLIDNTPKAKAKKKEAAVGRGRGRGRGGRGRARGRGRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX78</accession>
    <name>A0A8B7ZX78_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Chloride channel protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110989815</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022110153.1">
        <property type="nucleotide sequence ID" value="XM_022254461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX78"/>
    <dbReference type="GeneID" id="110989815"/>
    <dbReference type="KEGG" id="aplc:110989815"/>
    <dbReference type="CTD" id="1181"/>
    <dbReference type="OrthoDB" id="4564at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03683">
        <property type="entry name" value="ClC_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000003">
        <property type="entry name" value="Chloride channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000032">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050970">
        <property type="entry name" value="Cl_channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45720:SF10">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="830"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="831"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022110153.1"/>
        </source>
    </evidence>
    <sequence length="857" mass="95617" checksum="22F863F7051CD229" modified="2022-01-19" version="1">MALQPDRRELGYEQTLMYGRYRQELSQFAKNEAARQREEKKRQKQLDDEFRQYRGTCCYTVKSNLIWFRDFVFSKIGEDWIFLALLGIIMALLSFAMDYAIAKCQTAQVQLFMLLKGLPVLQYFGWVGFSIILIIFSSVFVHLVSPNAIGSGIPEMKTILRGVVLKEYLSFRTLISKVIGVAASLGSGLPIGKEGPFVHIASIVSTMLSKLIVTFKGIFENESRNSEMLAAACAVGVSCNFAAPIGGVLFSIEVTSTYFAVRNYWRGFFGAVCGAFVFRLLAVWNKDEETITALFKTTFRVDFPFDPQELIAFAFIGIVCGFGGALFVFVHRRIVDFNRTHKKVSAFLMKNRFLYPLVVSLVISSITFPLGLGQFMAGELTQKQQIDELFSNTTLGNDPTATIDEENKFKPWHRPNVFVTLGVFIVMQFWMTALAVTLPVPAGVFIPVFTLGAAFGRLVGECMAAWFPQGIHTSDAVVNKVIPGGYAVVGAAALSGSVTHTISTSVIVFELTGQITHILPVMMAVLIANAIAQLLQPSFYDSIIQIKKLPYLPDISHAGSKTYEIFVEDIMVRYVKFISWLSTYADLKELLDTSPKLQSFPLVDAPESMILLGSVQRSELEYMIEKKIGLARRLAVVADRKRAQGQSQPSPSDRFSVVSFNAKPDENNSQQISIRDAGNKDASAISLSNLELSLTVLLRTSPRASPRSSFSSQGMFRRYGSRDSIQSSSTDSLEGTKKKVRVYKLPIGEFEDMSVEEQEEWEADELKVQLDFSEVHIDPAPFQLVERTSLHKCHSMFSLLGLNHTYVTTLGRLVGVVSLKEIRRAIERSAESNNRGSFRRSQTEEPQNIIQAERSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXH7</accession>
    <name>A0A8B7ZXH7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GPALPP motifs-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108256.1">
        <property type="nucleotide sequence ID" value="XM_022252564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXH7"/>
    <dbReference type="GeneID" id="110988766"/>
    <dbReference type="KEGG" id="aplc:110988766"/>
    <dbReference type="CTD" id="55425"/>
    <dbReference type="OMA" id="NKAADFG"/>
    <dbReference type="OrthoDB" id="73491at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022226">
        <property type="entry name" value="DUF3752"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046331">
        <property type="entry name" value="GPAM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46370:SF1">
        <property type="entry name" value="GPALPP MOTIFS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12572">
        <property type="entry name" value="DUF3752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3752" evidence="2">
        <location>
            <begin position="246"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108256.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="43933" checksum="C219D0F9E8F645DD" modified="2022-01-19" version="1">MSDSSDCDIGPALPPHMRAASKGDRASGPEESRMEGRVTFRPVLPPHLSRSLSPEGVSSLSARPDEQCEIVGPSLSPDTRTDAGRTDGSSSPSICPIGPVMPPRLNTSDKGEKLAPEDSHDQEDSDPEDSTYGPALPPGFATSKRPSDKPCTIGPALPPGFRKTTAEDDGDVDPEGDEVSEDESSDEEEVIGPMLPADEGNSFLNTYLSQLSGLHLCMEQIHVEDVAPARDSWMTELPEFSKNFGLGPRTFRKSARPDEQDRSGWTETPADRARKHQERMEKAAAQMLASSSSKDVKEKKQKKEGRGEKKSERDKRLAQQVAQHNQTTRPESLMEMHTKSRKRKLAEGGLKEQERRPFDRETDLQVNRFDEARRKQLLKKSANLGDKFSHSNEKMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY86</accession>
    <name>A0A8B7ZY86_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110989548</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109715.1">
        <property type="nucleotide sequence ID" value="XM_022254023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY86"/>
    <dbReference type="GeneID" id="110989548"/>
    <dbReference type="KEGG" id="aplc:110989548"/>
    <dbReference type="OMA" id="WIPNKER"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF23">
        <property type="entry name" value="JUVENILE HORMONE ACID O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022109715.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29158" checksum="6B8145914659956B" modified="2022-01-19" version="1">MNFSAISDYECHGRHLHIALVNRNKNKLTLQVDDDVLDVGCGTGVETKSIAAEVKSVTGIDSSKEMIAFARANNSAPNVTYSLGDAQTIGDCSEWQERFDKAVSFFVLHWCPDHAMALRSILACLKPGGEALFIVCNRSSWVPESVQFVQNHIKWSTYGKDFKSSCQFWNMSVSEAEKLLASCGWKNVRCELQHHGQITEEPTKAMIKSGLGISAQIPESEMEEYLRDMWQWTLSQYGDSSKPGHVRIPAEIFIIQACKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYE2</accession>
    <name>A0A8B7ZYE2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Short-chain collagen C4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110990065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110553.1">
        <property type="nucleotide sequence ID" value="XM_022254861.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110554.1">
        <property type="nucleotide sequence ID" value="XM_022254862.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110555.1">
        <property type="nucleotide sequence ID" value="XM_022254863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYE2"/>
    <dbReference type="GeneID" id="110990065"/>
    <dbReference type="KEGG" id="aplc:110990065"/>
    <dbReference type="OrthoDB" id="6117306at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF18">
        <property type="entry name" value="SHORT-CHAIN COLLAGEN C4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022110553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022110555.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33629" checksum="25586BA879EAADCC" modified="2022-01-19" version="1">MALKSPTMIAGSRFLTRKSTPARNEKFGRWILAGVLLNLCLGISVSGRVVLQEDRWMSSEEPLSETADDVRIPESSKSGNVENQETEVAVAYGILRDTALSSEPDAAGEEHQEVTALARRSSGGDTYVRWGRTTCPRHSGTRLVYAGYATSSHYSHKGGTSDFICLPKNPQWASHKDGFNSHSFLYGTEYQVGNFDPFSHKNAEHLNNHAVPCAVCRLVRKTKLLYPARLSCPTGWRVEYSGFLMAGHYTHGRTEALCVDKEPEAVVGSSAAKYEALLYVMESVCGSLHCPPYVNGREITCTVCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYU8</accession>
    <name>A0A8B7ZYU8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL3m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L3, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110989007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108751.1">
        <property type="nucleotide sequence ID" value="XM_022253059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYU8"/>
    <dbReference type="GeneID" id="110989007"/>
    <dbReference type="KEGG" id="aplc:110989007"/>
    <dbReference type="CTD" id="11222"/>
    <dbReference type="OMA" id="NSKYNVM"/>
    <dbReference type="OrthoDB" id="274683at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000049">
        <property type="entry name" value="39S ribosomal protein L3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_uL3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022108751.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39565" checksum="044673D4C6E6DA7A" modified="2022-01-19" version="1">MQIVKMAAPMVITRVIQLVSKNSLLNARERLTRLCSCAVQRRTYYEYDTEYDTDIPKDLEDIVNKWSRVKNTLGPSPLKDEPWPHGEWEPGRSKRCGLVAVKLGMMPVWTKSGQRLTTTVLQVLENSVVKYTPPEENTLNPKYGCLLVGARNADPFKKSLLYSEQFKEAGLPVKDKLTSFKVSSNAKIQPGTPLHAAHFRPGMYVDCCGRTIDKGFQGVMKRWGMKGQPASHGVTKTHRKMGATGGGGTPGRIWPGKKMPGHMGNKMRWTLGLKVLRVNMKHNILYVGGSVAGHKFGYIKVIDSILPKNRDPEVPPPFPTYYEDEELEENLLDEELFDFNDPSIAYPEEAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0T9</accession>
    <name>A0A8B8A0T9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Retinoschisin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110990556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022111299.1">
        <property type="nucleotide sequence ID" value="XM_022255607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0T9"/>
    <dbReference type="GeneID" id="110990556"/>
    <dbReference type="KEGG" id="aplc:110990556"/>
    <dbReference type="OMA" id="WASESID"/>
    <dbReference type="OrthoDB" id="9973968at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="F5/8 type C" evidence="7">
        <location>
            <begin position="64"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022111299.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="23563" checksum="1A1B9783BE429292" modified="2022-01-19" version="1">MHSCGVESTARTCYFGPPLKPDLDNPDYWMKLVMKEIQEHCPGKRGCSSAEEGLTEPAPNIVECSAPKPLGLSDGTIADSQISASSSQPTFNAQEARLFVGDGWASESIDTNPWIEVDLGESTVVSGVVTEAYLYLTGICQLVTKYRVAYQTQSSSDRVLVTDGKGNATLFKGNTECGNPVMNLFNGSVVARVVRVEPVEWRTKVALKLELLGCRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A270</accession>
    <name>A0A8B8A270_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Bromodomain-containing protein 7-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110989697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109956.1">
        <property type="nucleotide sequence ID" value="XM_022254264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A270"/>
    <dbReference type="GeneID" id="110989697"/>
    <dbReference type="KEGG" id="aplc:110989697"/>
    <dbReference type="CTD" id="29117"/>
    <dbReference type="OrthoDB" id="21648at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05513">
        <property type="entry name" value="Bromo_brd7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051831">
        <property type="entry name" value="Bromodomain_contain_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021900">
        <property type="entry name" value="DUF3512"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881:SF27">
        <property type="entry name" value="BROMODOMAIN CONTAINING 7_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22881">
        <property type="entry name" value="BROMODOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12024">
        <property type="entry name" value="DUF3512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022109956.1"/>
        </source>
    </evidence>
    <sequence length="717" mass="79705" checksum="F8F65E5FF4CD2DCB" modified="2022-01-19" version="1">MGKKHKKHHKSEKNLPDVPVTRDLRAEPPLKLVLKVGGKLQDAKTGKFDICVSKPEGKSHHATLDDPRDHAPKSESHKKKKKKRKWHDVQNSNSEQEKEGVETEGSQEEQPMETDEPKEDIKQLLSNKIKMLKKQRCPEEESSEKAEDLIEQGSVASERTPRDQEQEVQRQTPSIREKENIEAMKVPLKKVLESLQKTIQRKDVDQFFAWPVNDVIAPGYSSIILHPMDFSTMKKKMDASEYTSIEEYKSDFLLMCENATIYNRPETIYYKAAKRLQAVGLKCMSKEKLSNLKRTFGYHESSDFIKFRTKTSKRLPQIDMDASTEDSSIMDVLDSEDSNILPTVGSGSVADGNEEESAEEIIEQAMQAAKEARDRLSARCPNSKLGFLRRDKTGTTTLAVLNPSLAGAEESKQVNLGMLTGRLTQGSGTLPGFREDKRNKAVPVTYMTHGPFSSYGPQYDSSFANISKEDSDLLYSTYGDETGVQYAQSIREYVEDCDDYVLKLVDNLLNTLTKGQHTKTMAVLQKKRGDKESENANRSDGQSTSGSGTSETAGSQDVVKKENKGVSSPIPFDSLRTLSDLGIDVSFLPAFEKLLGSDSYAAAASDSAEIDSKLKSTSELISDLEKTQSARLSQKPPSHLQFIPKPSEQESSIAEKLTQQLLQLTSKIKPSDVVSTEAARAAMGITADIQGDLVDEVQVLDKADSPQPLDVQEHTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2D3</accession>
    <name>A0A8B8A2D3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mannose-1-phosphate guanyltransferase alpha-A-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110991050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111844.1">
        <property type="nucleotide sequence ID" value="XM_022256152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2D3"/>
    <dbReference type="GeneID" id="110991050"/>
    <dbReference type="CTD" id="29926"/>
    <dbReference type="OMA" id="MPVPNWW"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="3">
        <location>
            <begin position="285"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022111844.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47165" checksum="D76C47A15434E811" modified="2022-01-19" version="1">MSYKAVILIGGPQKGTRFRPLSLEFPKPLFPVAGFPIIHHHIEACSKVEDLREILIIGFYQPSEALSRFLTTSQREFNVNIRYLQEYTSLGTAGGLYHFRDQILSGQPRGFFVFNGDLCCKFPLLEMLEFHKQQANGQHFTLLATEAPKSQSLNYGCLVKDPDTHEVLHYVEKPQTYVSSIINCGLYVFTPEIFEHISTVFKKNQDEIFNGDPFSSNKDTIRLEQDIFSPLAGTGKLFAYNCEDLMWSQIKSAGSAIYANRLYLGLYHDTHPERLAKDAASGPHIIGDVFIHSTARVDPTATLGPNVTIGAGVLIGPGVRVRESIILEGANLQDHCCILHSIVGWNSVVGAWSRVEGTPKGPNPNDKFAKMDSDNLFDDHGRLTPSITILGSNVNIPAEVMILNAIILPHKEIRRTFKNQILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2Q2</accession>
    <name>A0A8B8A2Q2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC110990509</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110990509</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022111245.1">
        <property type="nucleotide sequence ID" value="XM_022255553.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990509"/>
    <dbReference type="KEGG" id="aplc:110990509"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="64"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="13">
        <location>
            <begin position="271"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="13">
        <location>
            <begin position="357"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022111245.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="44407" checksum="FA0AA61D09AF6C3A" modified="2022-01-19" version="1">MYNVTSNFSLIIQNVTDSHEGTYHYVVESKVGQIDKGSVEVVITVTAPQPFPVVPGCDPRPSGPDTCMLQVPYDTMTVNLTCQVDHAKPPVDLQWFRVFHNGYTEHVESTTTTTMLVYQPGSSFDNTYVSSSMFHLSPTSNDSMVYRCDAYGVALGDKNGSHVLVTVSRDQLSIDTGTTQETASSSPPKNVQTALIVLVVIFGLLSLFFVIILLILRIRCRLLPTKLVRVKDATEDIEMSVAPTNGETDSDESSPLLAQNKSELSAPDQPQWKRLAVELGFTSDRIAYFKSFRPGEPEEKILLMLSEWRGLGSSLRDQTTKLCDALAAIGRKDLVYELQGLTDKKFHKISKDLCEAWEDLAYEFGLVEEELDEIKNKKSDSQDRAFKMLTTWRALXVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2Y6</accession>
    <name>A0A8B8A2Y6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110989869</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110989869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110246.1">
        <property type="nucleotide sequence ID" value="XM_022254554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2Y6"/>
    <dbReference type="GeneID" id="110989869"/>
    <dbReference type="KEGG" id="aplc:110989869"/>
    <dbReference type="OMA" id="YGHIHHY"/>
    <dbReference type="OrthoDB" id="10020332at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022110246.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39263" checksum="2F47B42F6899E074" modified="2022-01-19" version="1">TISTLLQGKKCSLTEAKDVIDISSEIEFLSLYPIINKDSKLLKSQNSPKIDPKLSYLSFTPGQCISTISLGDLEVSQWKMCREFGRRGSCQGEFEFARGIAAPQPGEIAVADVYNQRVMIRSNEGKYKKLIPLYSYPQDVAAICNHDNQLVVVDDTKYVKVFDKKNKLAFQFPTVPQSEVDRTEVNLCSVAVRKDGTILVGDVKRMVWTEHRPNDGQLLHTVPVPTPPWFLAVDDYTDRVIVNGVNEQRVYVVSANDTAQSIIEPTIDGQSVQVCSGVCSDKSGIYIAVSNRLGYGHIHHYDLDGIFLACLAQGLQFPYGITFTSDGQLAVADRFSIKMYHKMRRHQNDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3R2</accession>
    <name>A0A8B8A3R2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 2J6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110990779</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111570.1">
        <property type="nucleotide sequence ID" value="XM_022255878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3R2"/>
    <dbReference type="GeneID" id="110990779"/>
    <dbReference type="KEGG" id="aplc:110990779"/>
    <dbReference type="OMA" id="LHAFNWR"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF417">
        <property type="entry name" value="CYTOCHROME P450 508B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022111570.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58008" checksum="CDA9883854ECEA62" modified="2022-01-19" version="1">MELNLTWLWLLFSAMRTLLAFTILLLVLRWFLRRPRNLPPGPWEFPLLGSLPAIAWGLRKGLQPHHVLGRYAERYGPVFRVSMFNQSVVILDDFESTKAAFWHPQLNDRPSHGHSGVSQSSGEPWIQMRRFSLTVLRGLGIGKSSFEEQIGTEGEELLKEMSVINGKAFNPKPLLSSAVANVISSVALGIRYEYNDRHFKQLLVLLSSIITSTGPGGFVLVFPALTLLPVFKSNLKQLFSDFSQLLSFLTNIINSHRDTLDPHNLKDFIDAYLMEIKINAGTLAGASGELSRTATEERSIYSRLNETNMLYTVSDLFAAGSETTVTTLEWCFLYMAIYPEIQQRVQAEIDAVVGRNRLPRLADKPGLNLTRTVIWEVQRMASIVPLGLPHVAASDTQLQGFLIPKGTILVSNMWRIFRDPKIWPEPEMFKPERFLNDEGKAFKPEEFIPFGVGRRICLGEHLAKMELFIFFSYFMHRFTFMKPADAPPLALEGKISLTFSPLPFEICAVERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A5G1</accession>
    <name>A0A8B8A5G1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein LOC110991203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110991203</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112155.1">
        <property type="nucleotide sequence ID" value="XM_022256463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110991203"/>
    <dbReference type="KEGG" id="aplc:110991203"/>
    <dbReference type="OMA" id="HEGITET"/>
    <dbReference type="OrthoDB" id="7481671at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000343">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034892174" evidence="14">
        <location>
            <begin position="26"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1858"/>
            <end position="1879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1891"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1948"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1980"/>
            <end position="2000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2054"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2102"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2138"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="1287"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="1433"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="1870"/>
            <end position="2158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1039"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1057"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1064"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1076"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1231"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1269"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1583"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1595"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1615"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1634"/>
            <end position="1649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022112155.1"/>
        </source>
    </evidence>
    <sequence length="2201" mass="243642" checksum="6BAB152DB905FD12" modified="2022-01-19" version="1">MGWAWSWQVSLLISVALHHLKPVHSQGLDFLLQFPCRELQLNSSGPVIAMPDVLLPGTACINVTAPEEMTIKANLSSSKCNGLAFILSFNGSALFSLACVENMVIFSPQHLLTVYTSGSMESPYQYSFQAFPDKPECGVGDHLCYHNNGSFCVADDIPCVCITDGYCRHYGEECTYVYVASNQVVNISEEVKPYSAWSGEVSNETTCWTVPALVFETVKITLQSSVGRFFTQFGLRFLHEGITETFQTGDVIPRTISAIIPVPSSIILAVALYNESADATFKFALQKNDWNGLSTNPGGCLSNEFLCNGNGYLSACYDATIVCDGRLDCSSVLGLSDEENCDYCDDDDPILLPMNSHHDISFPGGQLRGDPTSLLSTTAECSWTVRAGNGQVIRIRFLDPYLDDFYLYFEAGSQRVAQLFNVKEPGRVIRNSDVQITFWKFYFLYPARLLLRVESEYPASCRNETEFSCARDNVCIPVSMRCDGFPDCDNKEDEFGCGECHPYEFQCSTSGGKSECVHEERLCDFLQQCPNLYDELNCGVCGPPVNLSGSGIYLLSPRRPLGYVPLTCIWLVYASPGHFINFRVINVSLTLSAAILVGSGHDPSDLNSTVLNKTTGTIPRVFTIHSEEAWISSITPSYVVNIFSFELAQLSETVHCNITEFACSSGVQCLPIDARCDSVRDCDDYSDEVGCATCGEDEFHCGHNDKCLDSQQICDGFIGCADYFEDEWDCYSTCGHRQVNVNSTILLSATSLEGLVHVCVWQVTSDINTFITMRVQKMVVDLHSYVAFGNGLGKSAPSSLVANETHMQVVGTLYFFNGNQMWIVAGAFFGIEVEFSAAQVKGSCDDPSLQSGSKCVPGSSRCNGRAELPNYADEVDCGFCGATNLDLSAHNQVVTVEVSKEIGSQQHLVTVSGRVDQGAPMVVANLTSNVSECFWKVTSPAGTRIAIEVIESWGSTLRIGNGLDPSVDSTVLLENDSVPFYRAVFSSGSLLWMTTALQTRAWASYQLRFNLQSFTNVDCESGQFACPSGSKCLDQSSVCNGIHECPTYADETNCTGCNDDAFACSARECIPLDRVCDGISHCEKRNDEFGCRYCGEPNIALNASVSRLLSAAENKIHNNSCLWTVTAEPYARIQVTILAYHSAQIIFCDGNYQDFLRDSNASQCTKLAEFHSDLRSTFRPYISSRGSTLWIESGPRPHIAFTLRQFVDIVCQIGQFKCPSGTACIDQADVCDGWPDCPEFEDEFGCRQCSKEHFACQTGGSCIVRPWICDGFPDCSDHSDEFNCGPCGETRINMTKLGYANLTSPGWPREYPSNLRCYWFAIAPQGHRILVIFLEFETQDGYDYLQLSNGLQFSNRYRISGSYFPSRVASKGNELALHFYSNYFTERKGFVLQVEKRPDNEVSCGVGEVMCDYPEFVCVPENYELLLCPTNYCGERIIVADPEPVNFTSPNYPADYPAKLDCAWTIMTAQGNVIFVQVHDFNTEARYDVLRIEGRTFYAVDPSEFSLDGRTKVRSMVFNSSSVTIKFKTDFSIQEEGFLLSIFEVPLYEPDWCKEDESSESDCEESLIEVVSCKLLNASLFECRDGSCLIPRARCDGFVDCSNSRDELGCTNVHCPGFYACYASAKCIDWEAVCDGVTDCDDGDDEERCDEKRCPSGCQCKYVNDDLHVRCREGWTPDIIHSIAKRTRALELTHGDIHTLQLGGFKGLSYLKALSLSGNHIQRIEEGAFSGLNITFLEISNNNITSIELPVFKELGRLETLLIINVSITSISEDAFEGLSNLQTLVIIAQLDGKFIEVQEEAFKNLESLRIVYVDDYRLCCDFAVLEHFSVNEDCITTELQPPLNLCGSLLQTNLLRVAMWVLGLSALLGNVVAIIWRLKGTGDRCKKTHSFMVMNLAVSDFMMGVYMVMVAAADLSYGETYFRVASQWRSSVVCKIAGVISVMSSEASVFFVTLISIDCFLCIVLPFSRIHLRERSTKIVVGLLWLVAICLSVVPTFSVGPDSDLYGLSDVCIGLPLTTKSTGQDNIKSEDIPNPLGSQQLTLSVGTDKKPAWILSVVVFLGVNLVCFLVVLSCYVAIFVSVRRTSKMVRKSSHRNREIKMAVKMALIVGTDFTCWMPVIIMGILSQTNTIEIGADMYGWIVVFILPINSSLNPYLYTIYTACMPSNTGNSNSYFQDKSDKKNSKARSVETLDISMSDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A602</accession>
    <name>A0A8B8A602_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110990621</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022111396.1">
        <property type="nucleotide sequence ID" value="XM_022255704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A602"/>
    <dbReference type="GeneID" id="110990621"/>
    <dbReference type="KEGG" id="aplc:110990621"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="109"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022111396.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="34090" checksum="1ED531A3496CB6A0" modified="2022-01-19" version="1">MQGPVVVGVTVPSDVTVQQEGTATLICRLESPINGLALWLEGATAFADKDQVLPDAPAKYSNFEIVNDDTAIGQMDLRINNAQYEDRGTYTCQFGGTPDGSATLEIQVPATSLTIAVNGTTQSPDAAVIVTAGTQVTLVCTSLGAKPKVTLDWFKGSEPLGPDTETIPSGGEATDTQKIPLNPVATSVVYECVADRDAPVPAASSQGVAYGNVGPNLSFPRDLVGIEKELGRGAFGKVLLGTARGIEQAGKVSKVAVKTLKEGADRQAKMELLAELDLMKKCVHRDLAARNVLVGDDLVCKVSDFGLARDVMNIRIYQRESQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XEA2</accession>
    <name>A0A8B7XEA2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="3">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110973020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022079074.1">
        <property type="nucleotide sequence ID" value="XM_022223382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XEA2"/>
    <dbReference type="GeneID" id="110973020"/>
    <dbReference type="KEGG" id="aplc:110973020"/>
    <dbReference type="OMA" id="TSQEVCN"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="694"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="770"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="694"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="864"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022079074.1"/>
        </source>
    </evidence>
    <sequence length="880" mass="97604" checksum="C4518FAC10D3859C" modified="2022-01-19" version="1">MGRKVTLATCTLNQWAMDFEGNCKRILKSIEIAKSLGAKYRLGPELEICGYGCNDHFYESDTCLHSFQVLAELLKSKVTQDIICDVGMPVLHKGVRYNTRVIFLNRKVLLIKPKSDMANYGNYRELRWFKGWAKERTVEEYFLPRMITRITNQTTVPIGDGVISTQDTCIGTEICEGLWTANSPHIGMYLDGVEIITNSSGSHHELRKCHTVIDLVKAATYKCGGIYMYSNLRGCDGERVYYQGGSLIGMNGNIVTRGDDFSLTDVDVDVATLDLEDVRAYKAQISSNNLYSAGVLKSFPRIKVEFALSGDVESSHRVNPPISCTLPTPEEEIAQAPACWLWDYLRRSGQAGFFLPLSGGIDSSATACIVASMCRLVCAAVNDGDEQVLEDVRRITADPSYEPSNPQELASRIFFTCYLGTVNSSVDTYTRAKNLAAEIGCNHTGITIDSAVNSTVNVFSKVSGKAPRFRAEGGSARENLALQNVQARTRMVLSYVFAQLSLWSQDKPGGLLVLGTANVDESLRGYLTKYDCSSADVNPIGGISKSDLRMFIKYAMEKFNLPSLRGIMDAPPTAELEPLKEGQVSQTDEEDMGMTYAELSTYGRLRKIAMCGPYSMFCKLVHEWKETCTPSQVAEKVKHFFRCYSINRHKMTTLTPAYHAESYATDDNRFDLRQFLYNTKWSWQFKCIDEEVERLNEERSKETKTERQKMSLDVSDRSNSENSHHASTSSNTTPHKVIQGHGVKVSKDSFVESVSCIPIVPTVTVTTATGEAGSLSDDSLGDEATPEAVTGTPTSADDTGAPRMRKRGHAGKSTAESHLDDSPKKRRTEVGNGNNNNGNSINHGSKDQTPWKRMGTWLKRRMSNENNAITSDTNTTKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XI08</accession>
    <name>A0A8B7XI08_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine-rich repeat-containing protein 20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079560.1">
        <property type="nucleotide sequence ID" value="XM_022223868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XI08"/>
    <dbReference type="GeneID" id="110973193"/>
    <dbReference type="KEGG" id="aplc:110973193"/>
    <dbReference type="OMA" id="MADAVYM"/>
    <dbReference type="OrthoDB" id="1060944at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079560.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19901" checksum="C7DE403E8BD66C3B" modified="2022-01-19" version="1">MRIVSMAAGDVTRVVHRCEQASEDCKLDLSHCLLTAFPDAVFHLTRHTTIESCDLSHNLLKKLPAKFAATFVHLKVLDLSSNKLESLQDGLSRLHDLQTLNLANNVLTVFPAAIISSLPKLEVLNLQNNSISDVDCQCLSTASSTLQEINLEGNPLTNNCRTLLKDVMEVNIKMTHSDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XI11</accession>
    <name>A0A8B7XI11_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110973380</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022079861.1">
        <property type="nucleotide sequence ID" value="XM_022224169.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973380"/>
    <dbReference type="KEGG" id="aplc:110973380"/>
    <dbReference type="OMA" id="MKEVDQV"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17971">
        <property type="entry name" value="DEXHc_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044762">
        <property type="entry name" value="DHX8/Prp22_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="13">
        <location>
            <begin position="255"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="564"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="745"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="129"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="330"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022079861.1"/>
        </source>
    </evidence>
    <sequence length="1210" mass="138138" checksum="C894E09F6CBE32BE" modified="2022-01-19" version="1">MEELDKLEYLSLVSKVCTELDNHLGMNDKDLGKCNIHLHDXYCFSSALQKNGADLPQSFVSNLLRLIQHMRPPKQAKTANEAKEKKPKVSELDKRRKKYPGLCLPDKKGEVETDEKVAQDAMDELEALMPLAKMPIKTEKSEDVKTHKKKKNRHHRRSRSRSRSRSSSHDRDRARERRKRRSWSKSRSRSRDRDRRRRSRSDSRERDSGKDRKHRRKRDRSRDRNRDRDWDKHKDSGSHADRFVNRPPPMDPEVGCIYDGKVTSVMQYGCFVQLEGLKRRCEGLVHISELRREGRVADVNDVVTRGMKVKAKVLSLAGTKIRLSMKDVDQDTGRDLNPMMSKGLAGSSNPEADDALRNPDRPSNLPLVSVPETDDVSIRKRVQRTTSPEKWELKQMMAANCIDVTELPDFDETTGVLAKEDDSDEEIEIELREEDPPFLQGHGRQSVELSPVRIVKNPDGTLSKAAMMQSALAKERREMKQAAERAESENIPTGMNKNWIDPMPDSERALVANVRNMGFTNQDMPEWKKSAFGGNKASYGKRTKMTIMEQRESLPIFKLKEQLVQAVLDNQILVVIGETGSGKTTQITQYLAEAGYTVRGKIGCTQPRRVAAMSVAKRVSEEFGCRLGQEVGYTIRFEDCTSPETKIKYMTDGMLLRECLIDSDLTQYAIIMLDEAHERTIHTDVLFGLLKKAVKKRSDLKLIVTSATLDAVKFSQYFFEAPIFTIPGRTFPVEILYTKEPEADYLDASLITVMQIHLTEPPGDVLLFLTGQEEIDTACEILFERMKSLGPEVPELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYVVDPGFVKQKVYNSKTGMDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAYRDEMLTTAVPEIQRTNLASTLLSLKAMGINDLLAFDFMDAPPTETLITAMEQLHSLSALDDEGLLTRLGRRMAEFPLEPMLSKVLIMSVHLGCSEEILTIVSMLSVQNVFYRPKDKQAIADQRKAKFQQPEGDHLTLLAVYNSWKNNKFSNPWCFENFVQARTLRRAQDVRKQLLGIMDRHKLDVVTCGKNTARVQKAICSGFFRSAAKKDPQEGYRTLVDSQIVYIHPSSALFNRQPDWVVYHELVLTTKEYMREVTTIDPRWLVEFAPSFFRVADPTKLSKHKKQQRLEPLYNKYEEPNSWRISRQRLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XI47</accession>
    <name>A0A8B7XI47_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Methyltransferase-like protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4 5 6" type="primary">LOC110973727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080464.1">
        <property type="nucleotide sequence ID" value="XM_022224772.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080466.1">
        <property type="nucleotide sequence ID" value="XM_022224774.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080467.1">
        <property type="nucleotide sequence ID" value="XM_022224775.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080468.1">
        <property type="nucleotide sequence ID" value="XM_022224776.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080469.1">
        <property type="nucleotide sequence ID" value="XM_022224777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XI47"/>
    <dbReference type="GeneID" id="110973727"/>
    <dbReference type="KEGG" id="aplc:110973727"/>
    <dbReference type="CTD" id="51108"/>
    <dbReference type="OMA" id="PYMHYVE"/>
    <dbReference type="OrthoDB" id="199041at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890">
        <property type="entry name" value="DREV PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890:SF0">
        <property type="entry name" value="PROTEIN-L-HISTIDINE N-PROS-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05219">
        <property type="entry name" value="DREV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022080464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022080469.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="37519" checksum="CD58B5EC7F658C2D" modified="2022-01-19" version="1">MTQQPRPYIRNPMLRMAYEHQTNTKFTRNKIRQHFDVEKWYKCNLDIFPEDLRVMFHQSHMDRATEKFLDISYRKSDWIITQAWHSLAKAFLGFFMSTTSINGLLDRGSMFVFSKEQFRSLLEIDADFKADHLLDLGAGDGKVTEIMASHFRRVSATEVSYTMQRRLRQLGYTILGLEQWAGHKYDVISCLNLLDRCERPATIMKDIHRSLAPGGVTIVAMVLPFKPFVETGSNQNQPIEELHLQGNTWEEQARSFILDFFTPAEFTVLAFTKLPYLCEGDTENPFYVLQDAVFVLRRSADAGMALPWASCESGADDSDVVVDITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIG5</accession>
    <name>A0A8B7XIG5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Alpha-1B adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110973457</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079996.1">
        <property type="nucleotide sequence ID" value="XM_022224304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIG5"/>
    <dbReference type="GeneID" id="110973457"/>
    <dbReference type="KEGG" id="aplc:110973457"/>
    <dbReference type="OMA" id="STCTHKN"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="75"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022079996.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="45744" checksum="A104D20FBA5103BA" modified="2022-01-19" version="1">MEGATDFISPDTSRHLVRETNETSTPTEFTTLAGYGEPTTADYDYYEGAFKFNDYTQRCIVGTIFVIVSILGTFGNGLVILAVVLSRKLRTVTNVFVVNLAVADLLVCLTLPWNAVGLFTRPELGWPLPEKLCVALALIVYTCGGCSLFTLATIAINRWMLITRPSRTYHTCYKPAYLAIMVVIVWLVPLLVAWLPPTLGLGELGYTKKYSTCTHKNSHELAPYYSLLQSVVFFPVPLLIIIVCYVKIFKHVRQHTKVLMGKQDQSAELSETSNNRENPSGSSVKCSKTELSPRRSQNLSVAKRRLSRRQIEITKNLFYVVCAFTICIMPYGVALLIPPSDPVIPWTAALFLVNSCINPIIYATKHPYFKQVFKLMLTCKCEGIPEQSDFLRSVRSTVRRDQGKRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJ80</accession>
    <name>A0A8B7XJ80_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic cation transporter protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110973456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022079995.1">
        <property type="nucleotide sequence ID" value="XM_022224303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJ80"/>
    <dbReference type="GeneID" id="110973456"/>
    <dbReference type="KEGG" id="aplc:110973456"/>
    <dbReference type="OMA" id="GRRTVCM"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="72"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022079995.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="56110" checksum="05CE01361EF2AFCF" modified="2022-01-19" version="1">MDVDISLKAVGDFGRVQGINFVLFGLCLTLASIQSNSIAFTIDQSVEHYCKPPQGFSTNQTAPLSNDTGRDIFHSCRMYDVLNGTLTDNLTTCQDGFEYPSEQGATSVVTDLNLVCDRSLLGGTLMSMHFVGFLVGCFLTGQAADMFGRRTVCMGASLLISLLGTSISFIWNLKLMMAARFFLGLVLPGNTLVCYVRMVEMALPRHRLLANQIIQLFSYESIRWLVQKGRVEKAVSILQRVAKSKKIQYEGESLMSRLSDIGVPTTEKTDGLADTPSVEDDGPTNGGLYPIKRHYSFFHLFRTRILIKYTLIMFLCWFVMNALYFGFIVYSTSLAGNKYLNFFLLALIEAPVSAIDFVLMKRFGRRRPLIFSFFACAVACYFTGFLPGKTANGTELTALIVAMAMVGKYFSTAAYEVTMLIGAEVFPTVLRNIATGSSATVGKTSTIIAPFIVLLKDAVSFLPMTIFGTLSLVAAFCVCLLPETRNRPLPEQFEDPTKLERQQEDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJE4</accession>
    <name>A0A8B7XJE4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein Nkx-6.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110973961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080923.1">
        <property type="nucleotide sequence ID" value="XM_022225231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJE4"/>
    <dbReference type="GeneID" id="110973961"/>
    <dbReference type="KEGG" id="aplc:110973961"/>
    <dbReference type="OMA" id="NYRPRAK"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF70">
        <property type="entry name" value="NK7.1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="191"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="193"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022080923.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="52419" checksum="803D33887E3C83A0" modified="2022-01-19" version="1">MFPQYRTDLLAMGLSSSKFHPMPVVSAAAFFPPVVAIGTWHPHNYRPRAKRPTPYYIADILGLWEREAAVAAAAESQRKLGLISAEHARAMTLADSPAVVSGGGKPSGKSASSSPGNLSADMDKRGVVKHAKDGHHHHHHQSKTHSKEVVEIVTDHTSDNRESVDSNEDENSGGAADRKRKGEGEMPDGKEKKKKARTTFSGRQIFELEKQFEAKKYLSASERAELATLLNVTDTQVKIWFQNRRTKWKKMEGISNAEAAEHKIGGPKHIDTIRQKQNSEAATAAAVAGTAEKASSPPMRAMAAPAPGDDDDDDEDEEEEDEDVNGVQEERCGSLCRDDGEDEMEVEVVPVAETAVAVTGTESEHGMEGRKEKCLKEEDRISGQEVGQRRRLACECDSVLPVSHHPLAVQTLASSSSSVAGLTPPPQPPCEASIEDTTEAKVGHVILRDEENGERENKMWESHARNTETILTDHYHQCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJP7</accession>
    <name>A0A8B7XJP7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973698 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080396.1">
        <property type="nucleotide sequence ID" value="XM_022224704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJP7"/>
    <dbReference type="GeneID" id="110973698"/>
    <dbReference type="KEGG" id="aplc:110973698"/>
    <dbReference type="OMA" id="CTIPKYF"/>
    <dbReference type="OrthoDB" id="10147574at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034622239" evidence="1">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080396.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28360" checksum="71642154DE359CFD" modified="2022-01-19" version="1">MLSSFIVCVLVVSAGAMAVKKPALYAEDVFGISPREGDDERKPCTIPKYFTYDQEEVMTTLEGGGLTVEYINFHGAYDEVLQRYSFETFLDFFNGTLLHLKVIAEYDEGKEYLLQRLGDEIECEVYDLEGKRFPEVYSFPEDAKFLRDSTIGDRDVAVESWYYVSDDGTLLNVKTVTKDECVPVSLFRRKFDPETGEELGVMNGQVHNFRLGICDPEGYFKIPEECKEVGVSKELSKNMQKMRRLSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN52</accession>
    <name>A0A8B7XN52_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone H3, embryonic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110974739</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082253.1">
        <property type="nucleotide sequence ID" value="XM_022226561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN52"/>
    <dbReference type="GeneID" id="110974739"/>
    <dbReference type="KEGG" id="aplc:110974739"/>
    <dbReference type="OMA" id="ICIVICK"/>
    <dbReference type="OrthoDB" id="9929128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022082253.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15366" checksum="5448801F8C0B4099" modified="2022-01-19" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRFRPGTVALREIRRYQKSTELLIRKLPFQRLIREIAQDFKTELRFQSSAVLALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN62</accession>
    <name>A0A8B7XN62_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110974272 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081496.1">
        <property type="nucleotide sequence ID" value="XM_022225804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN62"/>
    <dbReference type="GeneID" id="110974272"/>
    <dbReference type="KEGG" id="aplc:110974272"/>
    <dbReference type="OrthoDB" id="10072664at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="973"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081496.1"/>
        </source>
    </evidence>
    <sequence length="1246" mass="136748" checksum="694CC51C6AD94A3D" modified="2022-01-19" version="1">MSLIRVVLPGKAGQTLVGSDGGGKSPVRPAPHHAEDVLAEQAALKRATSSIQRQGDGSSNEAIPTHPSKSCTDPPGSRRPLTQQFDSSHSIDDIAVCLPAINYTRAHAREDARCQYTIPGHLPTLQRSKKTTQLKVSHHPSDLHASTRSEGAATAINVVLSIEGQDLKLPPPRDRSSPRQDHQKQRHRLRIRRVAGGLGFLPCRYQNEDIRSLEEGLKTLLLCQSMGVIIQITRHRDDNGSLAQPVFHCDRCLRHWAVHGRPPPDCQEPESRVSGPSFALTSRSHEILQKFAQLTPIDKQCFLEAIQAETVPTTRGGDGFCLTESHRRNQTGMGRQGDLKRPAAGMGDKEAITVWNLKSQLWQVAEDLESNLSTHRSLHEGGQNFAKSLPNDVPKALPSKTNQEEVTKDPTSSAEGEPSCESEQADTVSSDERDTRGGPDCHTGQGGSDPSIVDPVSINTGLRTPVADQASYLSKNHIINLDKDMKFQTGESALPLNSIKVNQVPVDIHANYPGFESPETDGHESNEASLQQEPVPKEERQNTGENCSPQYDSFNGGKDKIPDGNFLSCSQDLADEPPSSKTVESPVPHCTIRNCITDTEIDFVTNHRIFQDSEQLFEDDTAAHAVSKVTVTRSRLLQYLSYGAASFNNSAGADEVETNESFEKLINGPDDLGVSDNKDGNRPLPSQGKGNRQKIPSSKGGVGKGLAGQKNRRDGSISYMGVIEDEEETLDRSTSGEGNDSSRGGRGHTIRGSKSASRDQNAVPIRNTAVRNVTGKPDTRPGNLEQHVFATPRETLAQSNAFGAAHKSPENIAHQSSDEGLTKATFKQKIHDNGNNGLESGSSVQSSSAPRRESLGSHAAATALPPLGTVPGQLPSLNVHDTEQRSRTKDRKRSLGLPRTDHARREFVNRKEEEGPTAGWDTGREPMCDPRASRKQPPPRAGEEFDTSKRQSLARQQVSGGKPNTQDYFADDVNTKENGEKGERGEKSTGFLPAIASAKEDLMPKEMDDQLMREREAKSPMKSLFSQFDNFELSLSPPPAGSLHPVSTDKSFRMTYSTLPRTFDWDTARQPPGVTRRTPSPQRTGPVSDLSQLPADQALNAKLMKPSMVVRPSSRDFYDKSARTPSRVSGKKTDVYSSSSETSRASSPAESVWETVSEVWRRHALELQKLERMVALNFLPLTSAFTFSVFEIPPQYLAHNRSLREQAMQIRRLKRPKKIVMKFASKEQREAAMKPPQIRRRVKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQK6</accession>
    <name>A0A8B7XQK6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Golgi apparatus protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110974759</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022082306.1">
        <property type="nucleotide sequence ID" value="XM_022226614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQK6"/>
    <dbReference type="GeneID" id="110974759"/>
    <dbReference type="KEGG" id="aplc:110974759"/>
    <dbReference type="OMA" id="MMECLIE"/>
    <dbReference type="OrthoDB" id="2015434at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017134">
        <property type="term" value="F:fibroblast growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001893">
        <property type="entry name" value="Cys-rich_GLG1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017873">
        <property type="entry name" value="Cys-rich_GLG1_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039728">
        <property type="entry name" value="GLG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884:SF1">
        <property type="entry name" value="GOLGI APPARATUS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11884">
        <property type="entry name" value="SELECTIN LIGAND RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00839">
        <property type="entry name" value="Cys_rich_FGFR"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51289">
        <property type="entry name" value="GLG1_C_RICH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034859869" evidence="11">
        <location>
            <begin position="24"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1179"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="351"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="569"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="695"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="824"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="1011"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="repeat" description="Cys-rich GLG1" evidence="8">
        <location>
            <begin position="1074"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="26"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022082306.1"/>
        </source>
    </evidence>
    <sequence length="1212" mass="137312" checksum="90579DFB60C2C853" modified="2022-01-19" version="1">MASGLRVFLVTCVTLCIFPAIHGEFNPQDGTNIRQNNDPANVGGDRYPVKRDVGAGGGQRPLGGAAAMPAQRGFGPQQPQQQFQPNPKLAIAPNPNNPGGQGLGMLKQPGMPGDDIARGNFGQGARFDQGQRQPGQPGQLPGQQRAWVGRGDVAPKPYPAPGQGRPDTGRPSNRPMRINDSPQCREDVAHFCGKNARGNNFSVLDCLQNAGEKSTQAGGKDVGELSDTCNRFLWSYKMNLTKDVRFDSAAFEVCKPELKRFPDCDRIERGQGLLLPCLYDVAENITTIQCRQYINRMKAITFSDYRLIQGFYDQCRSDIESKNCGNVKNIQQDAPHRQGATINCLEKGVEKLQPECKKQILRVAELSANDYHTDRALYFACRDDRERFCEGEAAGQGAIYNCLLKHKFKEDMSENCRNKLTTRQKVASVDAKANYRLFRKCKNDIKKTKCNRPKDSQNREFRLSKLLICLEEAKHNTFTSYHANAEVAMATHFYHRWLPWYSGYSWMICVTICLSLQDLVKTADAGANYRIDKALHKACKPVRDKLCKDVEAGDAKILSCLMENIYSSEMTKECETELLLLQYFVARDFKLDPLLFKNCQRDVAEKCYIESADNSELPQGVVVACLHRYLHPENDFDKLTPGCQAQVHRVLRQRAVSVHLNPQIEANCREDLGKYCNEKTGKGEELSCLQEHLKELTQDCHSKIGDFTQEEAEDIKMNRKLMAACAPMIKQLCKDFLSKKVDEGAALQCLIDHKNDDSMNEKCQAGIEHFQLIQLQDYRFNFKFKESCRQDVIKYCKNAKDKSSIISCLSTKVRDAILMGHQHNISENCRKQLKAELLQRSEDIKLDPELFKGCEGDVQKHCNNLKAGKARILECLRDHRSDLSEACHVKLFNRVKEQAQLVKTDFAFMHACKKMITQFCTGTPPESLFKCLKSHKNEPTFDSNCKTVLTKRSIQRKEDFRLNPRMQKACRRDMPKFCSDVLDKSKKEEYKEKELEGEMLLCLKKKFPTKTLSPDCENYIRDAIQEASMDIRMDPVLFRMCKDTAKRLCSEELETPGQGLVEECLKTNLHKGKITDLKCRMQVIRLLQEGRADVHIDTLLYKACALDIKHFCAGIPQGEGRQMSCLLEALEDSTIKLHADCQRMLSERKEMWSYAVRESPPNSLQDLAAAINASEARGYFLTVLLVIIGVLFFGGLCCGRATKRVRAELKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR17</accession>
    <name>A0A8B7XR17_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110975266</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083288.1">
        <property type="nucleotide sequence ID" value="XM_022227596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR17"/>
    <dbReference type="GeneID" id="110975266"/>
    <dbReference type="KEGG" id="aplc:110975266"/>
    <dbReference type="OMA" id="RTVHTEP"/>
    <dbReference type="OrthoDB" id="10361348at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022083288.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="48015" checksum="611A9FEB928E1234" modified="2022-01-19" version="1">MNSRQPNARKIRLPKLPKNVSTVPSHRDRAALPRDELYPALSKSIIKVSGSLYKCNPRSSRSNGEFSPRTVHTEPVVLPSIRRKVQAYLTGDLKDKPKRLGQSKSDCISVATGVAFVEQKPVPLVKSEAPYPGTSDLQSFPKRALPQWTSTRVKPKSITNKTGYRLSPLPKNDYGDSLATKPELDNGLANTLDAFNEAKIEEFRWWHEKMRRIGGEDNPRAPPNTALDHEPSKAQNEQHKPAKTSANLNMISSKHRDKIHTAKKQRTVKSTSIGLASDVIHSNTSGLKHAHQRDGSVVENVDLNPTSSANDPSSGRPKFKANLIDVHVPAVLPHSSQSPRKVKQRERITQWLAQCEQAVQLSDNKHWFRLPGVDSDQSRCSTCEREFTHYSGIDTLAGDNTSTRPSYDFTKARLLSRDEKFHSSKPLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRR8</accession>
    <name>A0A8B7XRR8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PHD finger protein 21A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082887.1">
        <property type="nucleotide sequence ID" value="XM_022227195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRR8"/>
    <dbReference type="GeneID" id="110975071"/>
    <dbReference type="KEGG" id="aplc:110975071"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15523">
        <property type="entry name" value="PHD_PHF21A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102">
        <property type="entry name" value="PHD FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24102:SF28">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="334"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082887.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="52401" checksum="DC6A97C82A9306FB" modified="2022-01-19" version="1">MPVRVQCVAIRYTRTHCTSIITTKSASPGSFLSSQFCPILSPSLAILHHPEILVAKMKNDPQNVELKKQLHDQQAKITTLSEKQKKVVEQLRSDLGIQKESPVGKNEQVTSTPLTTSQNLNIPNRAVPTSTAAISKTPPGAQRGSSQHHHHQHQSPTTPTRMSILTNKPTTVTIKVPNVASRLAQSKHTPAGQPLQKEPSSPSNLYKKLTALPRPSAPGHGGVRNNATKKPLSPEEQKLEFMASLGLITQKTAEQLRCKRSERKRRSTANPQFSNYDRQEMESRQSATRFLEANGFGQEKRKRGKFHKGSEGSADNAENNLNGTLHKQEVDKHQDHCSACGLATDELLMCDTCPLVYHLGCLDPPLSAVPPGMWSCPQCKLKGSQSDWHGTLAIVHSYVQHRTMKEEEKRRLQKRASELQNERVQLEDKARQLNDAIAKQMQARDCLTESFRKTEKAIVQLQGFISRFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRY5</accession>
    <name>A0A8B7XRY5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110975014</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082759.1">
        <property type="nucleotide sequence ID" value="XM_022227067.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082760.1">
        <property type="nucleotide sequence ID" value="XM_022227068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRY5"/>
    <dbReference type="GeneID" id="110975014"/>
    <dbReference type="KEGG" id="aplc:110975014"/>
    <dbReference type="OMA" id="CDDLYTI"/>
    <dbReference type="OrthoDB" id="438211at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03155">
        <property type="entry name" value="CD151_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022082759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082760.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28281" checksum="D840722306A4FF5D" modified="2022-01-19" version="1">MGSPYDKEPCCGISLLKYILFIFNFFLLLGGAGVTGIGLWTLLKKWDYASLLCDDLYTIATWVLIIVGGIVIIIAALGCFGAQQEQKCCLLIYFTLLLLLCLGELLVGIYTYIYRDRVNMELERCLNSTLVANYGMPDQEDYSKGVDNLQRKFYCCGASGYADYQQSLWKVKGKAGNLSSPDSCCKTESSYCAVRDHPSNIYHLGCVDGLTNYFSGHLAIIGAVCMAIAGVQIFGLVFSMCLYCHLRYEEQEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSH5</accession>
    <name>A0A8B7XSH5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon catabolite repressor protein 4 homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082901.1">
        <property type="nucleotide sequence ID" value="XM_022227209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSH5"/>
    <dbReference type="GeneID" id="110975078"/>
    <dbReference type="KEGG" id="aplc:110975078"/>
    <dbReference type="OMA" id="MKEIDHH"/>
    <dbReference type="OrthoDB" id="10253982at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF98">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022082901.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="46766" checksum="D691F4DF3ED430B3" modified="2022-01-19" version="1">MDLSPNLQRGWVQRRARPQSADGDFVVLTYNILNKAFCPEGFYPYCPSDLLASGRRHPLLMKEIDHHRDADVLCFQEVNSRYYEEVLEPDMRSRGYTGCYFMRPEDETTKVDINLTDGSATFYRQDRFQLVKEEAGHFKHLFQQEIKLRQFQPSAASSLLDLADSTRVYIFTLFRCLKTKNLVAIGNIHLTFEFFIRMDLTTLEAAFAVNRLVQFAGGVDVPHILCGDFNQEPHHPGYQLLHDGTLNETMTTYLHTFDSRDCEQVTSLLDAFLGCFKHNSGSLKSAYKTVVGHEVPFSDYEDNSEYIRRPKTDQKSEAVQALFDGTSTHLKVRKTDPEAYASQKFVAALDYVWFSSNTLHCDGVLEMVDEELIVPFHACPNAAFPSDHLPIKTRLAFIKGSGKPRLNSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSH9</accession>
    <name>A0A8B7XSH9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="11">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19 20" type="primary">LOC110975206</name>
    </gene>
    <organism evidence="17 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022083155.1">
        <property type="nucleotide sequence ID" value="XM_022227463.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083156.1">
        <property type="nucleotide sequence ID" value="XM_022227464.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083157.1">
        <property type="nucleotide sequence ID" value="XM_022227465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975206"/>
    <dbReference type="KEGG" id="aplc:110975206"/>
    <dbReference type="OrthoDB" id="73209at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045664">
        <property type="term" value="P:regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000113">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000193">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF604">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665466" description="Tyrosine-protein kinase receptor" evidence="14">
        <location>
            <begin position="21"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1039"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="16">
        <location>
            <begin position="279"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="16">
        <location>
            <begin position="491"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="1121"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1448"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1550"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1617"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1698"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1485"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1514"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1553"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1585"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1702"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022083155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022083156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022083157.1"/>
        </source>
    </evidence>
    <sequence length="1794" mass="194970" checksum="6DA4C1B595A24ED4" modified="2022-01-19" version="1">MYFLYLHAVVALLLSLKSSALVYHERTYCLNPAQDTYIHGSRASLFRQDYLEVGRRSDGLDSRILLKFDPAEFLQQSQWGLESSFANLNSSVVGSVTLRLSCVNVVVRTSIFRGTVQVSRLLLPWDQTVVTASIRTLQGGVWWVGGIDTSGQDATAPFVRKEETVDYSTCQSGAVLSLDIDPGIFQSWLEEPLLNHGLLVWAEMSPGIQSTLRLASVDNGQVEKHPELIVSLQDTIVDSGVSCPSEQFQCLDGSCINQTKVCNFADDCLHGNDEATCSIKCDFESPCSWEMPPVSSGIPGWEMHSGPTDTAGTGPSGGQSDTGSDVSSSYLYVDATGKEKGTLSLLISPRYSESGPQCNLHFFYHMSGSDVGTLRVILILDRRNVTVWEKRGSQGNWWLGDVLALGRLKEPFRVMFEAEHEGGGEAGDLAVDSVELKDCSPALPVKDCMSSYFHCSNLVCVRPDDVCNLRKDCLFGEDEDAKHCGVIPFGGACSFEDGWCGWHNVIQGDDFNWTRHNGSTRTSNTGPSFDHTLGTSQGFYVYTEVSDLSPGSTAFLRSVLFPPPPEETYDPASPHYRTCKVRFFYHMYGNDIGMLKLFATTNTSERSYQLFSESYENSDMWQDHSTHLPVITESYYLQFESTRGLRFRGDMALDDISLSRQCFQLDDLSFGTAPPASTTEVRLTATWRSRSTKSTSPSSTPFLEDPMVFQFSNCGSKGEAGPSQTQCNVAYRHENVSVSVVDGIQKWLVPTTKTYSIKVKGAGGGTGVENTSPSRGADMEASFNLTAGDELFILVGQEGDDACDDGGETDFGPSGFCSSELTDEDRKRFGAAGNLAGGGGGGGGGSFVAKWDESSMEYIPLLIAGGGGGLAFSPSLSLVGVHGSADVPGPGLSGSQGSTNDVSGAGGGWNTTGANVTQASGKSFLEGGQGGRECGLARLEADWRTHGGFGGGGGGCTSGGGGGGYSGGDAPLIKDLYGNGQGGTSYVHPSGFDVKKKSGANLGAGEVVITALPTCGARTRMSEDRKTCISIPPDRLPSAVIVGSIVPVLIAILCAIAIIALLYYRKRKKPREATESLPMESADYQLNQLRHNASMDFNPCYQLGDGAVTVKDLKEVPRENLKLIRALGQGAFGEVYHGVFQPADEKEPFEVAVKTLPERSTEQDESDFLMEALIMGNFDHPYIVSLKGVCFTQAPRFILLEYMAGGELKQFLRESRPRRGHPSLLDMSDLLMAAYDVSKACDYLESQRFIHRDIAARNVLLSSKEKGRIAKIGDFGMARDIYRADYYRKGGQAMLPVKWMPPEAFLDGIFTSKTDVWSFGVLLWEIMSLGYMPYPGMSNQEVIYFTTQGQRMNAPRNCPRPIQELMYQCWQRDPGDRPSFCFILQFLSDCLQDPGILSAPLPQELVDDKTPTVTRPRNSKTSPVLKVHRSSAQSFDTAGAHANVEQGVVSSAKEDDEEYLTPDWVPGGRMKEHLISDDGNINNSADDHEACARMPAEELNHESVDKLKRRRKTKEGNGKPRPDSDTSFDPPINQDKCANEATDLLDRGEEVTAETSFTRSTTPRNSAKVSPLDFSRLVNQSSRDYSPDRATHVETDNRPCQPGTKCSILRNSHRAAAQDVSRLAQQSLQDPPQPEDLDATQDLCISSRAKQQSTAPSRDPATSGPSAAGDEALPSASFTPRILNRFRLPVFSRHSSWEVPNASASATSSVTPNSSLPMLNRMQSLPVRPNPYTMTDLSNQTSQASSTPDTSNVIIGASSGSSNNLYDAASRRVMFNSTSGQVVFEDDEINGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSK1</accession>
    <name>A0A8B7XSK1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-glucuronosyltransferase 2B31-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110975133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082965.1">
        <property type="nucleotide sequence ID" value="XM_022227273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSK1"/>
    <dbReference type="GeneID" id="110975133"/>
    <dbReference type="KEGG" id="aplc:110975133"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033989386" evidence="5">
        <location>
            <begin position="26"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022082965.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="55894" checksum="CE7BCF403EB0B90C" modified="2022-01-19" version="1">MSSKRFVLLLITSWFLATSIRRICGKEDPLDSKRYKFLYFISTVEGSHYSSFSISGKELVKQGHKVISLVSSSNSRRLQTADPDFSVVVFNSSYTPEKRAAVMEKIGKVIATGAMRGFFCHLESFMKGNLDGELNLGAMWLRECDDLLGDNATMRRLRQERFDMMVADDTVPCVPLLAQALDIPFVYCSAISPIPSKNGVWAGLPIEPSYISEAVVGFTDRLTFLQRVQNVLAHEYYKLLWFLAFNFKTFDQLKVKHNIRPEISTYESNKQASLYLFHGSFALEFPRPMQPNTVYVLYKSTAALPTGVKLADNTKVVGWLPLSQIMEHANVKVFASNGGSFGMYEAMWVGLPMVGLPLFGDQMGNFDRLEDRGVGLALDITTLTPESLSQTIQKVISEPRFRDNARRISMIMRDMQVMSPPGKTVAHWILHVTKFGGDHLRPAVLDLNFIQRNLLDVYLFIAAVLALFLGLNFYLCYCCCKCMCVKAWKSNLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XT23</accession>
    <name>A0A8B7XT23_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110975296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="6">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022083357.1">
        <property type="nucleotide sequence ID" value="XM_022227665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XT23"/>
    <dbReference type="GeneID" id="110975296"/>
    <dbReference type="KEGG" id="aplc:110975296"/>
    <dbReference type="CTD" id="1737"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="94"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="193"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022083357.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="57375" checksum="F459D889AAE2D666" modified="2022-01-19" version="1">MRICSINLRESRRRSRRCAEMQRSGLIFRACFRAQTLCRAPKISSGRVFFARAIHTCRAASRWTGRSSSSAFTGQTWLRRTPVRPFSSEDLPQHYKITLPALSPTMETGTLVRWEKQPGDSLSEGDLLCEIETDKATMGFETPEEGYLARTFVEAGAKDVPVGTLLCIIVENESDIPAFKDFEDSGEIIGSTAEEEKPAPPPPPPKPAPATPPPPSPPSPPPAAKPVPPPVPPMPSPAPGQRVFASPLAKRLAAERGINLMDVTGTGPGGRVRRTDIESYTPSAVAAPTLAAMPGAVYTDVPVGELRQFIANRVTQSKQMIPHYFLTVEINIEELLRLKDDLNQTVAADGVELTVNDFVVKATALASLKVPEANSSWMEDRIRQYHHVDVNVTVQTDNGMMTPVIFNVDGKGIGAINREARELASRAVEGTLQPQEYQAGTITVSDLSSFGIKHFATIINPTQSCAVAVGALQNVMVPDEDAEEGYRATTTINVTLSCDHRVVDGAVGAQWLQKFKTFLEKPHTMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTR3</accession>
    <name>A0A8B7XTR3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022083311.1">
        <property type="nucleotide sequence ID" value="XM_022227619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTR3"/>
    <dbReference type="GeneID" id="110975277"/>
    <dbReference type="KEGG" id="aplc:110975277"/>
    <dbReference type="CTD" id="80746"/>
    <dbReference type="OMA" id="LWRRWNP"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00324">
        <property type="entry name" value="endA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="360"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022083311.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55571" checksum="D09FE6F7B45EAB4D" modified="2022-01-19" version="1">MSALKPPRRKRRVYQQLDSPFPVPIESITKKPASNSRWFYYTGVLKENCVLVQQQGDVIFLYKLGFFGKGMLSKSKPEHSVFLNSYQGLRKKNLPPKERRFQQQRFQQVRKHRYERHLSWSRQFVRQAQNLAADDGKNDGSASVHDQPASPEVTGGQRQSCPTQGRNKRESTPSDDVTTGIDEVSPVTADVVPATDDITFDVTVRATAKNADVSSSTRSVDVDDAASRNDDVTSCDAVEVSGLPEASSKSAINLDIRSSTDETLEKVDSDTWRELEVAIQPEASSSSLPEAGVGSTEEREDQSITRKEDPYQIDEYLQLKLEEAFFLSYGLGCLTVLDEAKKALDLTDIWQAFCSRQKNFVASYVAYHYFRSKGWVPRDGVKYGAHYVLYKHGPPFYHGSYSVIVQMVTEGSWDCTDTSATLTWPALSGMDRITETVAKEVMLCYVIRPSNLSDEDLQSPGCIPQFRVQEILMKRWVSSRERDLKEHLPSLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XU29</accession>
    <name>A0A8B7XU29_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Uncharacterized protein LOC110975370 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110975370</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083510.1">
        <property type="nucleotide sequence ID" value="XM_022227818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XU29"/>
    <dbReference type="GeneID" id="110975370"/>
    <dbReference type="KEGG" id="aplc:110975370"/>
    <dbReference type="OMA" id="CVISINC"/>
    <dbReference type="OrthoDB" id="10051896at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000056">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="16">
        <location>
            <begin position="125"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="391"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="426"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="543"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="579"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="17">
        <location>
            <begin position="736"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="18">
        <location>
            <begin position="846"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="19">
        <location>
            <begin position="990"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="263"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
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        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="720"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="851"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="859"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1226"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1233"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1245"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022083510.1"/>
        </source>
    </evidence>
    <sequence length="1266" mass="137809" checksum="84E4ED32FE394290" modified="2022-01-19" version="1">MDNDSRDSVNGPASMTQTGGQLNEGSPDALRNKDHHGEPTWQNTLLHLGGPVARLWKKLRTRKKDGRRNVTNGATLIVVISAVLLTVGLGLILTIWSPFVANSTKRPSIDGPMPAPDSATFETPVIGPVEVNLTLEIDQKFKEEYYYPTSAGYKELEAMILTTIDSIFMNSDTSSAYEGSKVVGFRNGSVLATVLSRFRQAVVPASQNPSDLNAVLDTFVEYVQSLLESLTSQLGCCGGLQFISIIINGANIKSPFVGVSETTLPPQSVGSTTDPSTARLTDQQTDPLTTDPTHPPTAAPTDQPSHPQSVGSTHISNVQPTDSTTTLQPYTQTEEALTVAPSASPTSAPTDGPIEPPIDPTSEALTNLSTYQPTPPTSPTSALTESSTYFQTDGCVNSCLNNGTCEPVGWTGFTCECSAGFGGLRCEKELITINLGTNESTLVSSPSYPNNYPNNLDVVWIIQTVGNWRILIEFIAFNTESRYDFLQAGDGGNFSNSSTALFRVSGSNLPTRLLSVGNVMWLRFMSDQSVNMSGFSLSAQSVSSSGCVFNSCLNNGTCEPVGRFDFSCACPAGFQGIVCETETFFVSVNESSQITSPSYPSSYPNHTRLVWILQAMPNRKIVITFVAFNTERGFDFLEAGDGSDSTNFSNRFFRWSGSYKPPELLSNQNAMWLRFTSDGSVSHAGFTLLARSVPSNETLTCSDGELDCGHSVCVSDSLRCDGYYDCIDTSDEISCDCDSIFCQNNGTCMLFPSGYFRCLCSQGFAGRFCEKAFVECEAFPFIFQESDRCDGRITCPNGDDEKGCVCFVDCSGDDYLCRDSICVSRADVECNGVPDCLDYSDEGVTCNAAYCVEIQSEVCSAILTYNTTYFPNDFVKSHRQANDLITQHLPQLTVNCTDSERLALCMSFFPECPQFGSDRRVCATLCTRALECVGLDRNSNTTTLPCDVYPDRGVLSTSDGCFYNSEDVLQAGDCGRRPAASPSLNPFSRIVGGAQTHIANWPWIGSYRHASESHGCGVSLISRYWAVTAAHCSHLHHVVFGSSTLDIPFNYPHVHRVSKVFNHPRYDDQWYYHDIALLKLASPVRYTETIQPICLQIADNETEVYDRCHAMGWGRTSYEGIISPILKEARVPLLGWEQCNNNTGTRGRLFVSSSQICAGIGDEPNKTCNGDSGSPLVCQGTDGRWKMVGIANIAYRCGQTGPTAFTRVSQYINFIRYTIASDADLCGVNDFKCSSGTCITPELVCNKFPDCDDGSDEFSCDPGGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWL1</accession>
    <name>A0A8B7XWL1_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">Probable glycosyltransferase STELLO2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976025</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084642.1">
        <property type="nucleotide sequence ID" value="XM_022228950.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="STL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362:SF0">
        <property type="entry name" value="EXOSTOSIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31362">
        <property type="entry name" value="GLYCOSYLTRANSFERASE STELLO1-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03385">
        <property type="entry name" value="STELLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084642.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49899" checksum="D5FA40E91B9229F6" modified="2022-01-19" version="1">MAYLTETRVTTRSLLVVVFSVLAGMLLHNFVICKSSISFIRGTTGQQPVRCRTSAGGEGLTGRAYELRKVRTFEGSRALPSAASCRPFSPNAGRKCDRWIVVTTIYKPTPILPKISSLKGWCMVVVADKKGPQSMNIPNVDYLDVVQQESCGYKLCRVVPWNHFGRKNIGYLYAIEHGAKLIYDTDDDNAPLFPEVPAFDNVGYARYVTAGGAVWNPYPTFGQNTKVWPRGFPLSRIKDQSTKIAAESGKALPQQVGVVQFLAQHDPDVDAIYRLTSELPFDFNPTPRRLVVPKRMFSPYNAQATLHAHDAFWGMLLPVTVHSRVTDIWRSYFTQRLLWDVNLHLAFHSPFVRQERNQHNYMADFDGEMDLYYKTESLIKFLQDWKPRDSSPSLQQRLLDLTIELYEYDFIGAEDVAMTKAWIEDLQCLDYIFPLKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWN4</accession>
    <name>A0A8B7XWN4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cyclic nucleotide-gated cation channel alpha-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110975894</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_022228758.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110975894"/>
    <dbReference type="KEGG" id="aplc:110975894"/>
    <dbReference type="OMA" id="CYVYCFY"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017071">
        <property type="term" value="C:intracellular cyclic nucleotide activated cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005222">
        <property type="term" value="F:intracellularly cAMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005223">
        <property type="term" value="F:intracellularly cGMP-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000030">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.300:FF:000002">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032406">
        <property type="entry name" value="CLZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF11">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16526">
        <property type="entry name" value="CLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="516"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="705"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022084450.1"/>
        </source>
    </evidence>
    <sequence length="734" mass="83184" checksum="E7D25FF36ABA8FF4" modified="2022-01-19" version="1">MDKLIRKHKLGSAAAETLVTNEDPVDPASVPLPPDDDELDAAEQGQAPATGSQSRQSNQSRRSVLSHHGRKSNPNHKAQHLANEDQPPAATMLTVATNGDGGGVNSVDCDDPDSTEESDVEKRRKESAMGKIVGTLQVIKGWVTRGGEEQTKRADSFLERLAMAGPQMEDRSRVGTELGDGGTERPARVRVIERSDVFYYRWLAIIALAVLYNWYIIIARMSFTQLQLQYTAVWLTLDYVCDIVYILDIVVQFRTGYLEQGLLVRDPKKLRKSYVKSWMFKLDVLSMLPLDLLYIAFGVNTPALRVPRLLRGARALEFFDRTETVTNFPNIFRVINLILYIWIIIHWNACIYFIISVSIGLGSDRWVYPGMETPVDLSNDTLPHQYVYSLYWSTLTLTTIGETPQPVKDIEYLFVVFDFLVGVLIFATIVGNVGTMISNMNATKAEFQHSMDGVKQYMNLRKVSKELEGRVIKWFDYLWSNKKTLDEEAILNTLPDKLRAEIAIHVHLETLKRVAIFSDCEPGLLVELVLKLKPQVFSPGDYICRKGDIGREMYIVKQGKLQVVGEDGKAVFATLSEGSYFGEISILNVPGSLSGNRRTANVRSVGYSDLFCLYKDDLLDALKEYPEARTILEERGRMILMKDGLIDEEAAKRGTKTTEQAEQEEKLERLEANLNHLQTRFSRLLAEYSNSQMKLKQRITRLEKKMKGIKRESETSVLQQTDPPPSQPREFYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZV9</accession>
    <name>A0A8B7XZV9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2'-5'-oligoadenylate synthase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-5A synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085570.1">
        <property type="nucleotide sequence ID" value="XM_022229878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZV9"/>
    <dbReference type="GeneID" id="110976512"/>
    <dbReference type="KEGG" id="aplc:110976512"/>
    <dbReference type="OMA" id="ELLVIHC"/>
    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001730">
        <property type="term" value="F:2'-5'-oligoadenylate synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.20">
        <property type="entry name" value="2'-5'-oligoadenylate synthetase 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018952">
        <property type="entry name" value="2-5-oligoAdlate_synth_1_dom2/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258">
        <property type="entry name" value="2-5 OLIGOADENYLATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258:SF11">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10421">
        <property type="entry name" value="OAS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2'-5'-oligoadenylate synthetase 1" evidence="2">
        <location>
            <begin position="172"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085570.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38893" checksum="CBA64A6DFC815B87" modified="2022-01-19" version="1">MAEEKSPWQLRPGDLEAFVSSHLRQTDSFLAELRGALHNIVAYIQTQASFSISRYVVGGDLAGGTTALNEDAEFHLFLFLSDFRSIDDYQRRLEGVLTETRDLLSSEGVLHVVMLIEPNCVSDADGMQVIQVRVMAGEEWLEGTIVPAVDLIGSSPKKSNKETMYRQFVLDEDKSPYQPTLSDLRLSLIQSLPAPVKDTILLVKHWRKYRLRLRSDKPETRFYELLVIHCWEIAGNPKTFDLTVALKCILSCLSEWKNISIMWEDSSSLAYQRKIAEAKQREILARSHDNAGPIALDPIDPRVEYCTDVKTLIWDEISRTARETLMEPLFKGLSDDASWKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y041</accession>
    <name>A0A8B7Y041_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Proton-coupled folate transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC110977051</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022086522.1">
        <property type="nucleotide sequence ID" value="XM_022230830.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086523.1">
        <property type="nucleotide sequence ID" value="XM_022230831.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086524.1">
        <property type="nucleotide sequence ID" value="XM_022230832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y041"/>
    <dbReference type="GeneID" id="110977051"/>
    <dbReference type="KEGG" id="aplc:110977051"/>
    <dbReference type="OMA" id="NWDILEY"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="20"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022086523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022086524.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="54038" checksum="153281614D3AC823" modified="2022-01-19" version="1">MGCMQFVHRMLVAVTVEPLAVMTMTAVFFLTQGNQQFVYFKLCMIAYNETSLCSNLSAHPHAEDRIQAETSRWLLYIDIICYTPTLFTMLILGAWSDRIGRRPPLILACIGSTVLGTMLLVSALWIHLPMPLVLIGWACFGLTGSNGILLSMMFSYVADISTIENRVMRIAILEGAVAFSSVTGVAIAGLLTNSHSFQLLFGLFIVLFLLAMLYTVFHLKETRNTSPSKIETSESSSHSDSEADPLLNTQERNFYEGPTRNLPEEGGHASKGLCGKLFQRETLFGSFVALARKRPGYRRAVLILLLSCFFLLNSNYFGFINVFVLYTTKAPIEWTPLMTGSCSAVVALSNIVLLLTVIPVTRLVGIDVRTVAGMAIVMLGIGFVTMAFARSTPAVWLATVPLYFFELVITIYRGMMSMLVSPDEQGSAFALLDIMGTVAHLFASAVFDNLYPATLHIMSGGVSFLVMCGIEVAQLCLFLWSMFLQKCHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0W7</accession>
    <name>A0A8B7Y0W7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein LOC110976553 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC110976553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085611.1">
        <property type="nucleotide sequence ID" value="XM_022229919.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085612.1">
        <property type="nucleotide sequence ID" value="XM_022229920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0W7"/>
    <dbReference type="GeneID" id="110976553"/>
    <dbReference type="KEGG" id="aplc:110976553"/>
    <dbReference type="OMA" id="RDRMTWI"/>
    <dbReference type="OrthoDB" id="413653at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025633">
        <property type="entry name" value="DUF4291"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38567:SF1">
        <property type="entry name" value="DUF4291 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14124">
        <property type="entry name" value="DUF4291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022085611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022085612.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24808" checksum="8C5A170A025BAF83" modified="2022-01-19" version="1">MAARKVMFNFKTEPYKTQVQHHWPPSGRHILAQYDDETIVVYQAFCPEIADYAVSNQRFGGPKYSFTRMSWIKTNFLWMMYRCGWASKRGQERVLAICIPRANFDTILSQAYTAGAQREAGKMDVSVRLQWDPDHAPNGGKEDRRAIQLGLRGEILKSFATDWIVGIEDVTQFVKEQASILPEGEASLEKLLVARERVYAVPDKATAELIGCDQAEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1A0</accession>
    <name>A0A8B7Y1A0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Actin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110977271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086939.1">
        <property type="nucleotide sequence ID" value="XM_022231247.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086940.1">
        <property type="nucleotide sequence ID" value="XM_022231248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1A0"/>
    <dbReference type="GeneID" id="110977271"/>
    <dbReference type="KEGG" id="aplc:110977271"/>
    <dbReference type="OMA" id="MTARDGH"/>
    <dbReference type="OrthoDB" id="10022312at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086940.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="40186" checksum="AA71E0CDAA87345F" modified="2022-01-19" version="1">MNSGDTPPVVLDCGTLNCKAGLAEISKRVPDFVFRTSEPFMNCDLGEVPVPIRNGYIENWDSMEVLLEHIFKGKMKIDPTNHSVLLSEPDGNPHKCRKTSLEILFEGFKAPAVNLSNQGMLSLYSIGQATGLVIQSGHGLTNVMTARDGHRPTFGRVPLTYTGFKLTEYTQALIAASLREQHDIDIKTVDFKLAEKFKEEHGYLQMSQGDKPPQKMVMLDVGGKQYSIDAGEIGAKIGEALFDPSILGLSCFGLTKAIMESIELSDDEDWMDEFYLKKILLAGGNTMIRGLQERLTAEVDRVKFLSFMTVNVNAPPYRHFSNWVGGSIISLLPTFDPCWITRQEYEENGSNIFRQKCLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2D8</accession>
    <name>A0A8B7Y2D8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ceramide kinase-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086692.1">
        <property type="nucleotide sequence ID" value="XM_022231000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2D8"/>
    <dbReference type="GeneID" id="110977141"/>
    <dbReference type="KEGG" id="aplc:110977141"/>
    <dbReference type="OMA" id="CYLWYRS"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001729">
        <property type="term" value="F:ceramide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045363">
        <property type="entry name" value="CERK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF26">
        <property type="entry name" value="CERAMIDE KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19280">
        <property type="entry name" value="CERK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="154"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086692.1"/>
        </source>
    </evidence>
    <sequence length="618" mass="68209" checksum="854EE58EC8C67072" modified="2022-01-19" version="1">MAKSAWTDDLAVASPAPVDFRGAHIKLTNSEEETTPPTLPLRGIFDIKSKHYDVVLEKDRISWSLILPTMQSGRRRSIHASVSLHDVYAVGIKRVEKPGKNRGYPEGVIIYVATPSKKDPNVLTEERITLRSTNEDNCQKWRCAIDSALKGLGGRPRKLRAFVNDWVNDGEATRVFYSKVVPVFQVAGTRLDVIVTTREGSAHQILQKVDFDDYDGLVCVGGEETTREVIHGLLERTQLDADLVEITPDTNLTKCEIPLGIIPVGLFNLVAHSSQGTSDPFTAAIHIILGHLHPLDVSAIFHNKEFIRFGFSMMYGFAGDCLRRAEQRAKGVINARGLDYAVAKSVFKVRTYRCAVEYLPCESNGVFSERSPCRTGCERCKVKHPSNGEADREVSWPLTAGQRADDMASGCDNDTGHDRNGQVNRGCQDIETSPIRTKAADGTDKTQEWISVKGDFVSVGAMTLPNLCNWCPGGISPLTHLADGCLDLVLVRGTTRGEFVQHLRRHASDKNQFDFPFVSVHRARAVRFHPLGANDKPCTTIFDKGQGEGDTTCGEEASLEDDNGGAVPRTGKEFSMWNVDMELMASVPMEIRVHKQLLTVFASGIQDTDHSARSCRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2R8</accession>
    <name>A0A8B7Y2R8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110977217</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086827.1">
        <property type="nucleotide sequence ID" value="XM_022231135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2R8"/>
    <dbReference type="GeneID" id="110977217"/>
    <dbReference type="KEGG" id="aplc:110977217"/>
    <dbReference type="OMA" id="AWSIAPI"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022086827.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="69076" checksum="1910B6CB5B954D00" modified="2022-01-19" version="1">MLCKKKHQELKPASPSPAEEDSQEGDENKIRGNWTNRMDFMLSVIGYAVGLGNVWRFPYLCYRNGGGAFLVPYLMMLCLAGFPLFIMEVGHGQFASKGCIGAWSIAPIFKGIGYSMCCVTILCCIYYNVIIGYTIFYFYSSFTTEVPWRTCNNTWNTESCMTSNFTEDATRPSAEFWNNMVLARSEGLHEMGPIRWQNLVCLIIAWIIVFVCISKGVKSSGKVVYFTATFPYVVLIILLIRGVTLPGSLQGILFYIRPDFSRLADANVWKDGAVQIFYSLGPAWGGLHTMASYNKFHNNFYRDSLILAGVNCGTSILAGFVIFSVIGFMAEDMQLPLANVTDNGPGLAFVAYPEALARMPIAPLWSVLFFFMLFTLGLDSQFVMMETVITAVCDELQSFFPRIFKFKTWITLITCFICFLLALPMVTNGGIYIFSLMETYSAGFSILTIGFVECVVIAYVYGSKRFLKDMKVMLGFQLNIYWRICWMLLSPAIITFIFIFWAITYTSLTYYEYTYPLWAECLGWLMIMAGVVFMPAYAIYYMIIYGKGTIQERFAQGLRPEESWGPALDKHRLEAGYPLLAPGDDLVSTKKVNGGSYEMVASVDTSVKVTEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y337</accession>
    <name>A0A8B7Y337_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase Q</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Plasma glutamate carboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110977615</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="20">Homodimer. The monomeric form is inactive while the homodimer is active.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087593.1">
        <property type="nucleotide sequence ID" value="XM_022231901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y337"/>
    <dbReference type="GeneID" id="110977615"/>
    <dbReference type="KEGG" id="aplc:110977615"/>
    <dbReference type="OMA" id="IVFYNRP"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03883">
        <property type="entry name" value="M28_Pgcp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000036">
        <property type="entry name" value="Carboxypeptidase Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000009">
        <property type="entry name" value="Carboxypeptidase Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039866">
        <property type="entry name" value="CPQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053:SF3">
        <property type="entry name" value="CARBOXYPEPTIDASE Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12053">
        <property type="entry name" value="PROTEASE FAMILY M28 PLASMA GLUTAMATE CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="17" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase M28" evidence="22">
        <location>
            <begin position="286"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022087593.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="53989" checksum="A5A7EB5E35221821" modified="2022-01-19" version="1">MYKKVKMALKSLQITKVCCWILLVFVILLISLPSVSRSKPLLRRPDYDLQKIKQEIASYKDVANEIMAYIVNGSAKGQVYNRLALFTDTFGNRLVGTKNLENSIDFMLNELQKDGLQNVHGEEVVVPHWVRGNESAVMLEPRRYNLIMLGLGSSVGTPPEGITAEAIVVSSFDELKKRASEVPGKIVVFNQPWVNYGVSVAYRDFAAVNTAKLGGVASLVRSIAAFSIHSPHTGWQDYSDSIKKIPTACIAVEDAEMLARMAARGTKIVIQLKMEAKTYSQTISRNTVAEVVGSVHPEEVVLVSGHLDSWDVGQGAMDDGGGAFISWQALSIVKQLGLRPKRTMRMVMWTGEEVGGVGSLQYYQRHKANASNYDLVLESDMGTFTPYGIEIRGSNETLEIVKGIVELLGPVNATTFRKGEDGLDVSYWEKDGVPGGSLLNHNEHYFWFHHSDGDTMSVQDPHQMDLCAAVWTVVSYIVADLDNMLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3Q8</accession>
    <name>A0A8B7Y3Q8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Protein PAXX-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110977736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087823.1">
        <property type="nucleotide sequence ID" value="XM_022232131.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087824.1">
        <property type="nucleotide sequence ID" value="XM_022232132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3Q8"/>
    <dbReference type="GeneID" id="110977736"/>
    <dbReference type="KEGG" id="aplc:110977736"/>
    <dbReference type="OMA" id="HVIFRMA"/>
    <dbReference type="OrthoDB" id="5969703at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070419">
        <property type="term" value="C:nonhomologous end joining complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22286">
        <property type="entry name" value="HD_PAXX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027873">
        <property type="entry name" value="PAXX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054134">
        <property type="entry name" value="PAXX_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28586">
        <property type="entry name" value="PROTEIN PAXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28586:SF1">
        <property type="entry name" value="PROTEIN PAXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15384">
        <property type="entry name" value="PAXX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022087824.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22147" checksum="12587D309D1A2135" modified="2022-01-19" version="1">MSSAKSLAEEGEVAQIQAVVDCGSGRFLTFTSCIGDCWIVHVTDGIDVWRSIMDKTSLDSHRELAEVASYEAYFTRFKKAFTVGDLQITKQAHKVSLDVGTGSIALRYDLYEATASERKSDLKSVLFWLAETVIGVTNKLTKCEEELNLVKGQKGASLVATALPDIDSKKRSGQVRVQKQQGHSIVNPSSKKRKAAKGVQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3T6</accession>
    <name>A0A8B7Y3T6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-1,3-glucan-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110977749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087853.1">
        <property type="nucleotide sequence ID" value="XM_022232161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3T6"/>
    <dbReference type="GeneID" id="110977749"/>
    <dbReference type="KEGG" id="aplc:110977749"/>
    <dbReference type="OMA" id="HCTNDAF"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08024">
        <property type="entry name" value="GH16_CCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000217">
        <property type="entry name" value="Gram-negative bacteria-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034326694" evidence="2">
        <location>
            <begin position="21"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="40"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022087853.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44208" checksum="BD797597536252E4" modified="2022-01-19" version="1">MAQFVLSLVCLALLWAQSLTDNVPTPGITEFSPKPSGDKATSKCSSYPCPAGSLIFEDTFDTFNLDVWEHEITAGGGGNWEFQYYTNNRSNSYVRDNKLFIKPTLTSDRYGDAFITSGTLNLWGAAPADVCTGNAWSGCQRSGSYNHAINPVQSARIRTVNSFAFKYGKLEVVAKMPTGDWLWPAIWLLPKRNSYGGWPASGEIDLVESKGNRNLYDWQGRNVGVNQVGCTMHWGPFWPLNGWSRTHASKTVSSWQNFGKDFHKYELVWTSSGLKFYVDGGLLLNVNPGYNGFWGMGEFGKHNPGITNPWAGSKSKVVPFDQEFYIILNVAVGGTNGFFSDSLNNTPYKKPWHNSSGTALSDFWRAKHKWYPTWNPHVNNGEDAAMQIKSIRVWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y408</accession>
    <name>A0A8B7Y408_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977793</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087923.1">
        <property type="nucleotide sequence ID" value="XM_022232231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y408"/>
    <dbReference type="GeneID" id="110977793"/>
    <dbReference type="KEGG" id="aplc:110977793"/>
    <dbReference type="OMA" id="DCHEEQA"/>
    <dbReference type="OrthoDB" id="5983145at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038838">
        <property type="entry name" value="TRIR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34753">
        <property type="entry name" value="TELOMERASE RNA COMPONENT INTERACTING RNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34753:SF1">
        <property type="entry name" value="TELOMERASE RNA COMPONENT INTERACTING RNASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087923.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24470" checksum="17ACCC0F8891F56A" modified="2022-01-19" version="1">MEEKQSVNAFANDGSFMEMFKKRMEEEKLRCGSAGSGRAGVGSQSCQQLSMSATDDKDPGETLKSSDELARSSGTEDPAGRVTDCTEHANVKDVHLHRHSAMSAQIEGVELAMLTCTNMTKDIKDCHEEQALSLRDEHSTKSEGSKSIASSTPAQKKYSLLSHVGKRRDGKVALKTGAVKKQRKTEPQENKEQDSWSKYMAEVQKYKAHVCGDEDKSRPLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y460</accession>
    <name>A0A8B7Y460_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tax1-binding protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087332.1">
        <property type="nucleotide sequence ID" value="XM_022231640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y460"/>
    <dbReference type="GeneID" id="110977464"/>
    <dbReference type="KEGG" id="aplc:110977464"/>
    <dbReference type="CTD" id="30851"/>
    <dbReference type="OMA" id="TMATHRH"/>
    <dbReference type="OrthoDB" id="10033291at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF50">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087332.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="11259" checksum="06630BF6F1DD198A" modified="2022-01-19" version="1">MAVQGMGGIPCIDIILKKIPGAGLGFSIAGGIDQDKTKNPFIPGDEGIFVSAIKPGTPAELAGLAVGDKILEVNGLDLTMSTHSHAIKLLTKEKFTVLKMKIYRRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y502</accession>
    <name>A0A8B7Y502_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase-associated protein CTR9 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088278.1">
        <property type="nucleotide sequence ID" value="XM_022232586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y502"/>
    <dbReference type="GeneID" id="110977990"/>
    <dbReference type="KEGG" id="aplc:110977990"/>
    <dbReference type="CTD" id="9646"/>
    <dbReference type="OMA" id="EHWLTIA"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000069">
        <property type="entry name" value="CTR9 homolog, Paf1/RNA polymerase II complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000077">
        <property type="entry name" value="CTR9 homolog, Paf1/RNA polymerase II complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000084">
        <property type="entry name" value="CTR9 homolog, Paf1/RNA polymerase II complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000089">
        <property type="entry name" value="CTR9 homolog, Paf1/RNA polymerase II complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000289">
        <property type="entry name" value="RNA polymerase-associated protein CTR9 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="309"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="534"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="842"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="889"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1023"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1099"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1119"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1178"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1197"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1226"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022088278.1"/>
        </source>
    </evidence>
    <sequence length="1258" mass="140563" checksum="0B1610B9B85AF843" modified="2022-01-19" version="1">MAAAGLRFVEIPLRDTDEVIELDLDQLPEGEEVLSILKQENAPLHTWLALGLEYYKQNQVEDFIKIFASWQSDANLDYLGNEKDQMTALDTLAAYYVQRARKEKNKDAKKDLFTQATLLYTMADKIIMYDQNHLLGRACFCLLEGDKMDQADAQFNFVLNQSQNNIPALLGKACISFNKKDYRGALAFYKKALRTNPGCPAAVRLGMGHCFNKLNRPEKARAAFERALELDPKCVGAIVGLAILEINSKAADSIRTGVQLLSKAYTIDSSNPMVLNHLANHFFFKKDYTKVQHLALHAFHGTDNEAIQAESCYQLARAFHVQNDYDQAFQYYYQATQFASTAFVLPHFGLGQMYIHRGDSENAAQCFEKVLKAQPGNYETMKILGSLYATSLDEAKRETAKGHLQKVVDEFPDDVEAWIELAQILELTDVQGALAAYGTATRILKEKVQADVPPEILNNVGALHFRLGNLQEAKRYYEASLLHSKAEAEHDETYYGAISVSVSYNLARLYESMFQFDKAEKLYKDILREHPNYVDCYLRLGCMARDRGQIYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQQATQNDSYSLLSLGNVWLQTLYQPTRDKEKEKRHQDRALAMYKQVLRNDGRNLYAANGIGAILAMKGYIRESRDVFSQVREATADMCDVWLNLAHIYVEQRQYISAIQMYENCIKKFFKHHNTEVLTYLARAYIKAGKLKECKTCLLKARRVAPHDTLILYNIALVLQRIAMAVLKDEKSNLKTVLSAVSELETAQRYFTYLSKHGDRMKFDLAQAVVEARQCSDLLSQAQYHVARARRQDEEERLLRQRQDQERDALRQKQLEEQRARQQADEERSKALMEKRAQFIEKTKNILVVTSEPEPPRKSGAGGGGRRGKKTRAEVSSEGSESEMETGEAKPRKKRKKQRSDEEGDSEGKPRSKKRRPRKRAEGEESAPRRRKDRSGSRPGEGSSKKRRAMAREARIEEEKPGKFKSKAIVSSSESDSEGERLRIDEASDNETSRSNKPAPFKSRSRIRRVMSDSESDESRSDQQDSEDEGGSQTSGSESEAARKPRKRKVLQSDSDDEAEGQGSEDEGQGSGSEQHESGSEGARSDPESGREAGSRDEEEGAESGGEGVESGGEGVESGGEGVESGGEGAESGGEREESMGEREESGGEGQGSEDGEGSGGEEVESGGEGAESGMEGEGSGGEEVESAGEGEEAESGGGASENEAGVSDEESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5U6</accession>
    <name>A0A8B7Y5U6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC110978133</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022088567.1">
        <property type="nucleotide sequence ID" value="XM_022232875.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088568.1">
        <property type="nucleotide sequence ID" value="XM_022232876.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088569.1">
        <property type="nucleotide sequence ID" value="XM_022232877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5U6"/>
    <dbReference type="GeneID" id="110978133"/>
    <dbReference type="KEGG" id="aplc:110978133"/>
    <dbReference type="OMA" id="CGILPHI"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF145">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="338"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="89"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022088567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022088568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022088569.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="62739" checksum="24A2C8CDCB8C17CF" modified="2022-01-19" version="1">MGVNLLPARLSRQVMYDYLLIFTFLLLLMHVTYILTPDCVEEHGNVFESTQDSSAEKQRYIILGNENHLDEPKLQTLGGQNVYYTTIGAGKEKPLPHQEGRGQDDKRSLKMPRKITNELSKTKLASQNAPRQRNRTVKHSPILPHNKSSSLKAGGKRNFMPSMQNNSKMKSFKFSDESINKTNKIPARCQKKILIYGGIKVVRQWIELQVLVAALQLQDNGDWSTEVSCDQCTAQLILSNNMESLQGKDAIVFGMSPYSLKVKMATFRSYDFHSSQLLVFYGAETPLRMRKWVPDVGNLPVDVVWSYGQTSDIHIPYGYYQAGHPMDATRKSLPARTQGKRKLVAWMGSNCVKEVFWPRMNFVRKLQAHVPVDIYGKCGNLTCLPRLSSKCKDLMNQYKFYLSLENAECDDYATEKFWETALVHGVVPVVYGAPKRYYIQNAPPNSFIYAGDYRTVKQLAGYLISLDRSPQKYAEYLEWRYSGSVKQNFPNLKLAHFCGILPHIGSRGNGHAQRRNLAETTWFNSCRKMRRGDKAFRPADINATNWVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7R0</accession>
    <name>A0A8B7Y7R0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C11orf74 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088380.1">
        <property type="nucleotide sequence ID" value="XM_022232688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7R0"/>
    <dbReference type="GeneID" id="110978048"/>
    <dbReference type="KEGG" id="aplc:110978048"/>
    <dbReference type="OMA" id="HEQENCT"/>
    <dbReference type="OrthoDB" id="10057631at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097731">
        <property type="term" value="C:9+0 non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120160">
        <property type="term" value="F:intraciliary transport particle A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007340">
        <property type="term" value="P:acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040028">
        <property type="entry name" value="IFTAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35543:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35543">
        <property type="entry name" value="PROTEIN C11ORF74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17722">
        <property type="entry name" value="IFTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088380.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="32997" checksum="2D34B5D72A97E8DF" modified="2022-01-19" version="1">MAARNHEQENCTNSPTHMKQDHMRSAIETVLGKTEQSYEEFMSCFIGLKKEDVMEHQACQLHKMLREQDGEPAGGQRSHRTEEHKDPKASRADSEQGDIEMEELDEGHYAPTRQITDLTTGPRFVQMDNFVEDAELSEEEPGADDDDADFASCQYESSFKIVDSSSASPLKLTGDLVRRIGGADDGEDDKLEISQGQLEVIGGGGCEMRTLPGEAEEQEEVGVSSLSNDAVHQTELDMSTRRSPEAVTPGDSPPSEMGLEISSDEVQPFSLDTDFDYDNVSLTPKWDSNHGPPGWKPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8J7</accession>
    <name>A0A8B7Y8J7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Uncharacterized protein LOC110977868</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110977868</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
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    <sequence length="379" mass="40142" checksum="641CFB2573A0E0BC" modified="2022-01-19" version="1">MTLPMKNCSLACLVLILAAGGSVRGNQSSGAMNGTSTPAAATAPTEVTGQSTVGSTGAIATTAGTASTTSPAVTTANLTTTVALTTSAPPTTTLGLPASVNQSELIPTYQINDMDGHVCILAMFTATLKIKYDKTDGESAEAVIPFPESLEAYGECERYSMDHREFFFAYPNNSSYTLRLRFSFSIYKINQKPVGLLFPELEVVWTYAAPFFPDNAERLGREDGRIFTSFVSEMYGYSAAFKCDILTLSDATITLTLENMLVQPYADFGGFGYGDVCNPTSPSVRPVFPTTTQPLQTTEILPNATTLEATSNLSTTTWQPTSPVPVSAPTDHTGLIVGTVVGAVLAALVVAGAVCLIVRRRRPKQIPYGAVMDTLETGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8B7Y8L7_ACAPL</name>
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        <submittedName>
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        </submittedName>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        </source>
    </evidence>
    <sequence length="3825" mass="421778" checksum="A08AB80F773E0E31" modified="2022-01-19" version="1">MPKKMDPPPKRHHPSLADRVTGRAKVVTFFKSGDRNFKGVQIPIRKKYNFSTLLSDLDRVSNFPFGVRRIVTPSATHDVTELEDFEDGKMYIMAPTKKKPKPLDLAGIQARPPWAPSKALPGSGASGAEAELISPRKIPGNHANGNLRSSESMHRTVKKLMVMRNGDPHSKHMMLLNRNKIPSFEAFLTDVGESFQLPAQKLFTSDGVRVESLSAIFNGSEDLFVVGTGVEKFRPGSYTENSPFKPSSRQRESLRRKSTDESDQPPQKIIKKSRGKFHMWVATSENPSAGTDATVSITVYGDKGXSDDIVLGCGNGKFESGNEDEFNINVGSIGDIYKIRIGHDDSTEFAGWLCEEVRLQDVHTGDEMVFPCGRWMSRQEDDGQTCRELPVMVDGSPVFPIVSYHVAVVTGNYWNAGTTAKVYITVYGERGDTGPRLLHKTKRAKKFEKGKTDVFNIEAVSLGMLKKILIGHNSTDPEDGWYLEKVVVKDHKGSSLESVFPCHCWLDATLDEDGKTSREIYVSNKPTNLEKEMWEQEKWKFKPSNQMVFISKGSGKAVQIKADGSVEATADPYSLPKTAIFEAQKVKPNVHIISSVANPEHCITMDSNKISNKGKGNELKLRVQMDRSIVIETAKNSSQLLTFGQTGKPGDVRGPALGPNRQFFCYVKGMFRDEGITMFYTSRIQTLTVTPDRSCRATGQRSEEAYWRIHKVGDSGSVRMLESLSQPGSFLRIKDGHCDVQGSGDNCCHFKVLRVKDKGYVSLQSVESADVCVGFVPDGNVKPTVDTGEDNVRLYPHVIQFGTKKSVVTPTPPTSAKPAVNRKKRVLNKQSNGNAKKTAALPLTPTPTPSPPVREKSVYDDGDWKVWVKTGKAGTKASVVLVVYGEEGVSQPFTLGKGGKELFKAGEENEFKVNVLSVGDIYKIRIGLDTTSKKAAWRLDQVKMKDMITEEQLLFKFKNRWLSPNEDDADVWRESAAVRPGGKPLPINKYSVQARTGSDVGSSTDANVYLCLYGEKGDTGKRQLIKSNHAEKFQESQTDMFELEAVTVLTPTKVVVGHDGKGPGAGWFLDEVVIKEAKTSKTEYVFPCNRWLDEGQDDKLIERELELGEVREIQPHEWQVYVTTGSDNSAGTTAMVTLVAYGDKDKTEVALIPKGDNGFRPGTTHDFRVYLGDIGQLYKIRIGHDNAAKDASWYLKTVRMLDLNELTEMEFAFDRWLSEKHDDLDVWRELPAVVAGKKPLPVTRYYVQVYTSSEENAGTEASVYLQLAGKNGDSGKRRLVRSKNNKDRKFLAGQMDVFEIEAVYLGRLQRVTVGHDGKEAGQGWFLEKVVVKESKNAKNETLFPCKKWLDAGQDDQKIERDLTPAKPTSAPNPVTSESAASKTDSITISWKPPTSGKVTGYRVTCDPPDAPASEVIITDAKTTKAEFGGLIPGRAYQFDIVTINTDLESDKVSLKTNAKPNAVLDAALESTVDAVIVSWTHPQGELSGYKARISPSDAKKSVVKIKDPSKTRTEFVGLAPAKQYKVDVVTVSGEVESEKVTLQETTKMPEIHVLKVPNAEATKATSESLAVSWTKPEGDVTGYRLAILPAEGATPDLKLDGADKTTAEFKGLSPGQEYTVEVYTVYKEQESEKMTLTARTDAQSNQPKDPTASSTPTTISVSWTKPEGTVTGYRLLCTPADSETSEIMIDNGDTTTVQVDGLTPGRQYELEIYARNGDVESNKTTLSQRTKPSEVLDARIESSSTDTVNLAWTRPEGDLTGYRIEYQPVSKEETDRQDKPADGHDELVDHRDKPVDDQDKPVDDRDKPVDDQDKPASGQTADSQTVSVDGADTTNCEVTGLTPGQRYLFNIVTVSEQEESEKVSVNCTTKPLPVLEPKTNSTTESVTVGWSAPDCQLTGYRVVCRLKNSDSQEAKGGEEGQSNEMPEKTDQPKAEDPADSPANEKPERSNEPKETEDPASSDPGNEGSPADETAPSSVEKSPANASLSTEGSKQVVEEKKVEADVNEVEFTGLTQMTEYSFDIYTVCSDVESEAVTVDEKTKRVKLPTQGEWKLWISTDEDSKPPHNARAHIVVYGEKGMSPPIMLTEEEEHAYFQAGNTDEFKISVGDIGDIYKIRIGHDDDTEWQGWHLKQVKMVDQHSEEELVFEFDRWMSRQEDDFDVVRELPAVREGQETLSVNVYRVCVSTGDHWAAFTDAKMWVVLHGERGDTGKRVLYQSLNNPVKYMKGQMDEFKVEAVSLGEVSMVEIGHDGVGYGAGIFIDSVTVRESEAADKEYLFACHSWLDDHMEDRQTSRQLQLLGVRPIVSDSNDEPTQDSADTSWKVIVQTSDLENAGTTSNVYLTVFGDSGRSPSHTLQGKTLDTNTEQEFDVDLGDIGEVAKIRLEHDNSGDSPAWHVQQVRLVHAAKPELVFQVNTWLSSDQGDNPSTVKEVAAIRAGVDPLPVVNYTVQVQIREDPDSASTNPDLSIALAGEAGEMAKWELIRTGKPVCEDGKVKVDTFSFDAVSVGQLERAILSISSKEKQDTWFVEKVTVREGKYATTRGVFPCKMWFGNAIIGEDGSTVLQTDLKPEGEEVVPKDKEGSEEDDGESSSKGRWTVWITPGQDDGMGTDANLSIQVYGEKGRSEVIPLRAEGDDKAKEDNEGQGADERKATPSKENEAETDESADKAEENGDGVQDLAFSPGSTKEFDIDVGEIGPIYKIRLSLDSCDMKDDTPSIFLDKVKMKDKGTNQEFHFFINRWLCCPDDTKLLPTEASPVEAPEPGAKQEDKSGKKSEEKPGDEKKTTSKAGKTKDHKEEKVEDKKREEEADKEDDETKDEATEQMQKTQAGDEAVDCYLELPAIRPDIPPLPVLTYELSVRTGDKGAASLSDVIYATVYGARGDTGCRILRKSNNPVMFKQAQVDIFAIEAVDILRPSSITIGHHSEGFGAGWYLDTVTLKQSALATTQYVFPCKRWMDTGVDDRKLERTLPLLGEVACPPSTTPDTKGLWQVRVKTSDQPDAGSTARVCLVVYGEKGQRSTHRLEREAFQPGSEEEFEINVGDIGAISKIRLQHDNSGDSPAWHVNSVGMKDVDSNEELDFRFDCWLARDQGDGQLCHEVPATREDKDPLQVYNYQVKVHTGDLDNAATEGAIHMTLQGSIGDSGERLLTTSNNSQKFGKGQVDMFTVQAVDLGKVHTITVRNESTEPSQAWYLDRVVVKTSPKAEREYVFPSSRWIGPVDPESDELKAAENDAELPVQEKWKCTVQTSDLPECGTDASVSLVAYGDRGVSKVMSLTNGQEGNFKPGKSTVFELEPGPCIGDIYKIRVELDDGKDKSWHLKQIDLQDCFSDESLTFEYNGWLSRIQNEGKGDVIAEIPALRPGEEPLPSVMYYLQVFTGEAEDAGTDSEVSVTLFGERGDSGRRLLNKPRDGEKAFNEPQKTDIFDLEAVSLGSINKVLIHKASGRAWYLDRLIIKEGEFAAAETEFKHEGWLGSKENPDQAVDTELVPTTERPSNTVAPLPEGQEPVQSKGNWKVFVTTGEAETAGTEANMTVTVCGSEGTSQPMPLAQDGQPTKMEPGQTQEFEVNVGEVGHIYKVRLEHDGTTQESDWFLEKIKMNDVDTKAEFSYTVSRWLSRHQDGCNRVIEIPAIWPEKPIPEVVKYKVQVLTGDLDGADTQADVYLTLRGEHGETGRRDLVRDPGDPTAFSKGHTDKFTVEAVSLGRIDKCVVGRDGDQPESGWFLDKIIVSKSGEESGGVTFPCNRWLAADKGDNATEVELDPLPLSEGAGDGAGDGSADAQADAGQEGEEAKADRAQDDEAEDGEAQEKDDDGKAPEGQDEKKDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAL8</accession>
    <name>A0A8B7YAL8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC110978609</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110978609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TspO/BZRP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089425.1">
        <property type="nucleotide sequence ID" value="XM_022233733.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089426.1">
        <property type="nucleotide sequence ID" value="XM_022233734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAL8"/>
    <dbReference type="GeneID" id="110978609"/>
    <dbReference type="KEGG" id="aplc:110978609"/>
    <dbReference type="OMA" id="VVWRHIK"/>
    <dbReference type="OrthoDB" id="5586934at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.100">
        <property type="entry name" value="TspO/MBR protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038330">
        <property type="entry name" value="TspO/MBR-related_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004307">
        <property type="entry name" value="TspO_MBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802">
        <property type="entry name" value="SI:CH211-161H7.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33802:SF1">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03073">
        <property type="entry name" value="TspO_MBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022089425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022089426.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35347" checksum="3147B059BF60AB11" modified="2022-01-19" version="1">MDNKKHSVLFICLVILVLAEFIMTLFVNALAGIGSSGTSIDWFLNSTGEISDYYYVEITPAGWTFTIWAFIYTYQALIVLYWLTSICRRNKTGYVYRSPAVITPVMLVLYAINLVLNMTWLFLFDRQYLPAAVVVSAFLPTTLCIILFMNHRLVDQHGYDLVHNKRGDLVAIRAIIQNGMAFYATWVTIATLLNLSIVLSYWGGMEQSTACTISLSILLVEVLLYSVLENVVWERYLRYTYTVWLVVIFALIGSIAKNWNVEKTNSIFSVVLCGLAFALFLIKLVVSVWRTFTYPLYAESTSLSKEELALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBR8</accession>
    <name>A0A8B7YBR8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110979315</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090699.1">
        <property type="nucleotide sequence ID" value="XM_022235007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBR8"/>
    <dbReference type="GeneID" id="110979315"/>
    <dbReference type="KEGG" id="aplc:110979315"/>
    <dbReference type="OMA" id="DHANNAR"/>
    <dbReference type="OrthoDB" id="250836at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675">
        <property type="entry name" value="MUSCLEBLIND-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12675:SF6">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="791"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="791"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="461"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="873"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090699.1"/>
        </source>
    </evidence>
    <sequence length="1053" mass="120426" checksum="94024E5913E328AB" modified="2022-01-19" version="1">MSGESEANGSNTQVCREYLRGECDRGSNCKFSHPDLKEGSNEMKDKICRDYLRDECSRGDRCIFQHPPGLQGSKRVIKFCHNFQNGRCPREGCTYLHCTQEEEEYYNKTGKLPPGAEEQIKSEQAKKVCKDFLNGKCFRSQCKFAHPGSDGYGYGGPPRKRPMPPWEDRNAFYPPVREDRERVRSLMRLVNDLEDENVVLRHKLSRIHRQVLDLTDDNKALLDENRRLRGDPEAPRAPPHRAEAASGDLDSYLRDRPVAVPAPHAPALDPVTSRAAARNTGFESERAAPYSSDRPGYESRLSSGYDYKMGCSYGVNCKFDHPEWARGLSLLPKICGQYRHERDGEKCPDQDCKYLHFTDEEHQAYIKDRIIPARFDLKLNRDNNQLVQYSSDEEPDHANNARPKNRAREDGGRNQRDSRRHRSGSPKRERSPKRVRSRSPVRSSSRSAKREESPEDDAKRLQKLKHTIKDLKKELDNLWKDNKHLQRQLSDHKRFHETDQELINDLMRTRNKLEDDIGRLNAEKIDMTKQISDLFSDNKVVVEENQRLRGLLQAQESRLPSTQTATPVAQSTFQDPFSTSSSSSSMFQQSSWNYTYGRPSLVICSAECRVRAASRCHLCSKPAAFEQQQEAASSLKRQQQPLRHVQLIRKYLPQGYGHILTLSLLDHIKYVSFHLSSLPLILDKQFSQMSTGEKDYSDDICRDYTRGVCNRGRNCKYKHPEELEGVESKGNHKYAFCHDYQNRECVRPNCRFLHCSRAEEDYYKETGKLPPHLEEKVARGYGITGAESSGFDEVPICRDYQKGECNRGSKCKFRHMSRGDMEYEERRRMRSRYPPGGYGEFEYDRLRRRPLEDRFGYLDFETGRGSGDEFGARMAIRERVRSSNRDTRELEEENQILLRKVEVMRKQISDLTAANEVLLEQNARLRASKSENTNNAVMQAETHLVRSTTGVPLLSQGSVAVIQKSAGTPGASGVTAINLIGQQEGGLGDRSQATLIASEMQTIPVSVSLQQEFQPVSLASVMTTQPTMPMQSVPTSILTYPIVSHNIHTAMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCA5</accession>
    <name>A0A8B7YCA5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">COP9 signalosome complex subunit 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110978547</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089316.1">
        <property type="nucleotide sequence ID" value="XM_022233624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCA5"/>
    <dbReference type="GeneID" id="110978547"/>
    <dbReference type="KEGG" id="aplc:110978547"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048624">
        <property type="entry name" value="CSN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21151">
        <property type="entry name" value="CSN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="263"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022089316.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54679" checksum="6ADEA941C409C6EE" modified="2022-01-19" version="1">MPLPIQIFGQGPVEAMQVDMQPEGSDSPEELTYMVDNPTLDLDGYASSYTGLAKINRLLFVAAHCPSLKIEAFRIALSYTQSTYNTSMYQNIQRKLTEAVSSTSILPDAVAGVVHNVPPFDTQWVETTNKKAALKLEKLDTDLKNYKSNSIKESIRRGHDDLGDHYLDQGDLSSALKCYSRARDYCTSAKHVVNMCLNVIKVSIHLQNWSHVLSYVNKAEATPEISEGHQRDSKDNLTIVTKLKCSAGLAELAMKKYKPAAKYFLQAVFDHCDFPDLLSPNNVAMYGGLCALASFDRQELQKNVISSSSFKLFLELEPQLRDIIFMFYESKYASCLKLLDDIKDNLLLDMYLAPHVNTLYSQIRNRALIQYFSPYVSADLLKMAASFNTTVSELEDELMQLILDDQINARIDSHNKILYARDVDQRSSTFEKSLAMGLAFQRRTKALILRSAMLKNNIIVKFANSLPRDGCNAADSMVGISTATPTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDW8</accession>
    <name>A0A8B7YDW8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-phosphoinositide-dependent protein kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110979717</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022091449.1">
        <property type="nucleotide sequence ID" value="XM_022235757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDW8"/>
    <dbReference type="GeneID" id="110979717"/>
    <dbReference type="KEGG" id="aplc:110979717"/>
    <dbReference type="CTD" id="5170"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01262">
        <property type="entry name" value="PH_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000126">
        <property type="entry name" value="3-phosphoinositide dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000163">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000191">
        <property type="entry name" value="3-phosphoinositide-dependent protein kinase 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033931">
        <property type="entry name" value="PDK1-typ_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14593">
        <property type="entry name" value="PH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="186"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022091449.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="72700" checksum="FBE26C0267BF32C9" modified="2022-01-19" version="1">MSSVDSLQRAVEPAGAPQSPSAQLVCTGSPSCLCGHSELAAVNNGLCSSANSKKSRLAVLRFARMLAVALRRWTSKTKKSKEQARKPMRGGEGESRDQSATNGRSQSQCIKPPASRTVSAGTSCQRDSASPSSSPAAATPTSSSLPSTSSEYLQSRPSAGTPGAKDMNQSGQSATTAPRKKQRQDFKFGKILGEGSYSEVVLATEIATGNKYAIKVLVKRHIFREKKEKYVMREREVLSKLDHPFFVKLYFTFQDKEKLYFGLSLAQRGELLPYIQKLGSFDENATRFYAAEVVLALEYLHNMGIIHRDLKPENILLNEDMHIQITDFGTVKILDANAKEVRANSFVGTAQYVSPELLTEKCAMKSSDLWALGCLVYQLLAGLPPFRASNEYMIFQKIIKLEYEFPEGFPEKAKDLVSRLLVLDPLKRIGCEDCGGFPELKDHPFFEGVNWDNLPNETPPTLKPCMVVDGEEIHSDLYIDEFDMSPLSEFLGQIKTYENNRQQTKDRSQRKPKYVLPYTSEERAALLEKQRRECKWHRFVDGNLILKMAPMDKRRGLFARRRQFLLTEGPHLYYVDPENMVLKGEIPWSPHLRVEVKNFKTYFVHTPNRLYYLIDPEGHALEWCRAIEEVYRHTYQTNEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDX9</accession>
    <name>A0A8B7YDX9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRP15-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110979268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090595.1">
        <property type="nucleotide sequence ID" value="XM_022234903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDX9"/>
    <dbReference type="GeneID" id="110979268"/>
    <dbReference type="KEGG" id="aplc:110979268"/>
    <dbReference type="OMA" id="NAGWADC"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090595.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="34676" checksum="FD4A16CE0BDBEE48" modified="2022-01-19" version="1">MAADMSAHGPDLATTAVSPDNVVSFVNSDATKKQNKNLKRWRPFVKVSYDSGSDADVESDEDRTEKGTSSKTTSTRISRKRQKLEGASPPASPASEHPDSDGESRDSEEDPEGEEEPRVPGAGWADAMAKILQRDVPGELGSAVLAKSKDYQKAKQLEEVEYAERRKEKEMKDQWENMGRVKPRVTDKELERKLQRIATRGVVQLFNAVKKQQKKFREKPETAGSERKHAEVKSSVSKGDFLDLLKATPVISNRNASQNKQAGDKPANKKPAWSVLRDDFMMGATMKDWDKQSDSGSEEPGGGDSEGNSFSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YG65</accession>
    <name>A0A8B7YG65_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Uncharacterized protein LOC110979812</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12 13 14 15 16 17" type="primary">LOC110979812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091582.1">
        <property type="nucleotide sequence ID" value="XM_022235890.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091583.1">
        <property type="nucleotide sequence ID" value="XM_022235891.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091584.1">
        <property type="nucleotide sequence ID" value="XM_022235892.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091585.1">
        <property type="nucleotide sequence ID" value="XM_022235893.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091586.1">
        <property type="nucleotide sequence ID" value="XM_022235894.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091587.1">
        <property type="nucleotide sequence ID" value="XM_022235895.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091588.1">
        <property type="nucleotide sequence ID" value="XM_022235896.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091589.1">
        <property type="nucleotide sequence ID" value="XM_022235897.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091590.1">
        <property type="nucleotide sequence ID" value="XM_022235898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YG65"/>
    <dbReference type="GeneID" id="110979812"/>
    <dbReference type="KEGG" id="aplc:110979812"/>
    <dbReference type="OMA" id="IEYKVYS"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056217">
        <property type="entry name" value="THSD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24306">
        <property type="entry name" value="THSD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665564" evidence="6">
        <location>
            <begin position="27"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="7">
        <location>
            <begin position="429"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="613"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="687"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="736"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="787"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="889"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="974"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1179"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="977"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1041"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1058"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1104"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022091583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022091584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022091585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022091586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022091587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022091588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022091589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022091590.1"/>
        </source>
    </evidence>
    <sequence length="1222" mass="133730" checksum="AE228955405CBA5A" modified="2022-01-19" version="1">MSVGLQPWKAAWLLAFLLSGIRLGSCARRHRLWVPDDHVALNGDVTVEFQRPRDDVLPNGVLELRDLSGSDNYRTEKGLPNRPNGNVSFECSYFDHAGEFEVRMLRTSGGEILATSSVIHVTWPIVNVIAPRTHVALEGGIAVTVTTTANLCTDMQYNRYENSVVLLYHDVNRTLSQTEMITSSHGSVVVEREVGTLTAVHLEQFECQTIDRAGIYSFIYCSSYRRLILGTSQPVEAAWSGRYRVTFPRETVFPCPDQTAVEVSFDAPNCRGDRDKIRVYAETGRFELRPTGTLDYVTEVTVMGTSVIFDCSHFSLDHLGYCFVYVSTAKNGAVDAHRDKILCVPVEAIGPPVDGSWSVWSDWGACTVTCGEGQRNRYRLCNNPPAANGGALCVGETVMSQLCNYGVCPAHTDPTDMVSEPTVKPNCTCGGCTLHADPGGIIASSPYDCTSPLTEGTVASPGGQVLTWLVVGSDHQRVRLEFRAFNLHPQEEWMRIRDGGDQRAKVLAYHTGSRLPAVVESTGNRLYIEYKVYSGGEPDRGFRVRYSSLDGGIPPTTPVAAGSTGDEEAAGLNLGSINNTVMMVGIFLCAAVILVSIVITVFTGCRKSKSATEIELRPNPGPGSSIASAGGGQRPWGPPGHSCSSQSEMSHQSGKRGRPDGHLGDRSQLYMVQDEGLAYLPESNVSLSSPYHTHSSDTTGVRRPPKIPEDKIPSPYHSPRTDFIQMERLRKVGLPYHIGTGSSQSEVSRHSGRTDKNTTTLATKTPEYLAMRGYSAAGSLTSFEQKYGSLPRSDHRSDNRSEHRNSDQRHSDQRHSDHRHSDNRHSDHKSDHHHSDHRSDHRSDHGFDSNLPCVNKEGQLTPLGMALSRNQTFNQNEFRTPEVLPHIPEGQPAPVNHVTKWPPTPNEGRTVAEINRNTPVNRKKSAHGENSVHPVGVQQPLVNGESPSGQRPRKLPLTPRQAFFEDTESLGVVTPMTDISSKDNMQIRSPRSTFSPKKNEVVDISNKGVTSPLSSPGELAPGHTGNSKRFPDRNNSGAGGRSKRKKIPHASSARKTRKSESKRTSSGDEDGRTAAKLALYSTAESDDASATNLLSEPTSPVRIPELDKKQNTDRLKSVFISDESLAKTFSGGESSRSGMTPRTPRRLPNTPPSGFSPTSNKLKSVLVYSDFSIDQDEPEYDDFIPNLPGTFFENQTPLPTGLSPARKKNQPLKKSSHSASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHY5</accession>
    <name>A0A8B7YHY5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MYCBP-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092227.1">
        <property type="nucleotide sequence ID" value="XM_022236535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHY5"/>
    <dbReference type="GeneID" id="110980156"/>
    <dbReference type="KEGG" id="aplc:110980156"/>
    <dbReference type="OMA" id="IMNANEA"/>
    <dbReference type="OrthoDB" id="10263316at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032707">
        <property type="entry name" value="MYCBPAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48421:SF1">
        <property type="entry name" value="MYCBP-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14646">
        <property type="entry name" value="MYCBPAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092227.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="63521" checksum="B6A5C5E63CFD8F9E" modified="2022-01-19" version="1">MNLGDDYRKTQEDRYLIERSIPAVDYGRGYRIGSEFWSQQERIGDDLSGIHMTLTETERGYPPPIEHIGQPTAVKKEIGAQLDSSRPGTSINYPWHQSKYLKDRRQQLDNVMLNLDPHTPDLSKLQIIGRNNPYANQMDKHTSEDAKIPEMTSLKPNISKTTVRNDVTEEQTGPCLQLHSFTASWSGDSHSNKGFTAHVARVTFEVYAGEPITSYLNLVNKGTTTIYYDWKKIPKLNSFEGCASPKVQRFYFNTSSGVLLPGESLKFPFAFKSPNAGIFSETWQLDTRPVLCGGAALQVALRGIALQEDKNKRQRDQIEQNLFTKQAVMTARRILEDLIDGIRTPERPCSPVDAYITQEELFQQHNKGVYYSNEIVSQLNHLHSEQFDEDARPSHSWDLSIKTLRKDFLALENEGKREDLLTKMNAAITCLYFPPLNPIQQEMYRVGYQLLIKAVDNIVTQASLIRDHLGLPTKDVEMPDTDQILGANDHLRGGEIKKKKKEQKEEEVKKDGKKENKKGKKELDLIVRNSRHCGCCGRTNPEGKRSISGIMNANEAKGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLX2</accession>
    <name>A0A8B7YLX2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-5AC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094264.1">
        <property type="nucleotide sequence ID" value="XM_022238572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLX2"/>
    <dbReference type="GeneID" id="110981205"/>
    <dbReference type="KEGG" id="aplc:110981205"/>
    <dbReference type="OMA" id="VPCACEN"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022094264.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="30423" checksum="057F2841C944F6BD" modified="2022-01-19" version="1">MHAASTLATTTSETTISSDTSPVEATTEDLKSKISTGPSDTTVSSTTPSVETTSRELKSTESTVLLDTTGSSTTLVVRTTSDDVVSTVTTGVSETTISSDTATTQDLQPTVSTAPLETAVSSTTWKMETTSEEVVSTVTTEVSETTLSSRTSPDEATTEDFKSTQSSAPSETPGSSTTVTVEATSEDVTSAVTSGISETSISSTATPKEEATEDLTSAVTSGTSESPISSATPPVEATTQVADFRSTVSTAPLETTVSSITLTVETTPGDLTSAATSGVSETPILSTSPITEKTTEGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLZ2</accession>
    <name>A0A8B7YLZ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Somatostatin receptor type 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110980913</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093677.1">
        <property type="nucleotide sequence ID" value="XM_022237985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLZ2"/>
    <dbReference type="GeneID" id="110980913"/>
    <dbReference type="KEGG" id="aplc:110980913"/>
    <dbReference type="OMA" id="VRWPFGE"/>
    <dbReference type="OrthoDB" id="6076970at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004985">
        <property type="term" value="F:G protein-coupled opioid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001418">
        <property type="entry name" value="Opioid_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00384">
        <property type="entry name" value="OPIOIDR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="60"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022093677.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="47324" checksum="236B7E5C40B5E059" modified="2022-01-19" version="1">MADTVTETYTSLVPINETEWGRDNNGSNSYYEGDGHSVTRVIGIVMGSLYLLITVVGLAGNGTVIYVILRYAKMKTVTNCYIMNLAMGDTLFLIFLTFLAVASLQDQGWVFGPVLCKVVFSVDGMNMFISLFCLTAMSIDRYVAVCHAMKSRAFRNLRVATAVNSGIWVLAILAAIPIIYFTQYHEETEFDPAYCFLTFPEGQMFTMSRYLLIYFFIVGFVVPLIVIIACYASIMVRLRDMNKKTGKPEKSRKVNRMVLIVVITFVVCWWPFYLFRFLSLYWKDFRGWQGSMVITEMCMGLSYLNSCINPLLYAFLSDNFRKSFQKAWCCDGDSRSEISLASHASRWKFGKNGGRGRPKKKGGRFRLHDDEGDDENISGTNNQYPLTATAVTSAMSESNYPRNGELAQVQMDHTAIAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNB6</accession>
    <name>A0A8B7YNB6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ceramide-1-phosphate transfer protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLTP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094162.1">
        <property type="nucleotide sequence ID" value="XM_022238470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNB6"/>
    <dbReference type="GeneID" id="110981161"/>
    <dbReference type="KEGG" id="aplc:110981161"/>
    <dbReference type="OMA" id="FSHACTL"/>
    <dbReference type="OrthoDB" id="116883at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000002">
        <property type="entry name" value="Ceramide-1-phosphate transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF43">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094162.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24029" checksum="488FDDD68A024341" modified="2022-01-19" version="1">MAGKELFDFKHLLEEFTASKTPENHILMDRYVNAFNDLSRFFVLLGTAFGFVSKDINEKVGILKAHRAENPDHFATIQSMVAYEVANDLTQAKTKSGLLSGSRTLLRLHRTMDFVAKFLGRLKDMKDEEYTSKAASEEYSQSLAKFHPWMIRKVAGVAMYTLPTRGVFVQKYCKQEKEELETLVGPTAAIMTEIYDITQQLYADNNILDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YP35</accession>
    <name>A0A8B7YP35_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CWF19-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110981621</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095028.1">
        <property type="nucleotide sequence ID" value="XM_022239336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YP35"/>
    <dbReference type="GeneID" id="110981621"/>
    <dbReference type="KEGG" id="aplc:110981621"/>
    <dbReference type="CTD" id="55280"/>
    <dbReference type="OMA" id="IVPITHY"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000024">
        <property type="entry name" value="CWF19-like cell cycle control factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="5">
        <location>
            <begin position="310"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="4">
        <location>
            <begin position="436"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="263"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00041007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022095028.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="60026" checksum="DBD55165742DFCAF" modified="2022-01-19" version="1">MSAKALKILVCGDVEGKFCQLFSRVSSVNRKAGPFEMLLCVGEFFGTAEEEWRKFETGEEKAPIPTYILGPNKPENMKFIKDINGCELCENITYLGKKGIFNAASGLQIGYLSGTEQAHVAVQEPNNFSKADIDALAVPLISDSKFKGLDVLLTTPWPKGVFKYASTPEGLDPTTTGSSLIADLALALRPRYHFAAQEGAFYERLPYRNHKVLTETTKHVTRFLGLARVGNPEKKKYLYAFNIIPMKSMEREELVKQPQDVTECPYNWSGTRPEQRPEVDMSNQYFFSQSSGGRGRGQKRSRGQHHSGPDRKKRPQPTGPCWFCLGSPEVEKHLVVSVGTTTYMALAKGGLVPDHVLILPIGHYQSIVDLPEDVIQELEQYKSTLRRYFRSRGKTCVIFERNFKTQHLQLQVVPIGRALCDDIKDVFTSKAESQKLDLFEIPKHTDLKQVMSVGNPYFYVELDGGVKLLHQIKKNEFFPLQLGREIMACEELLNMPERANWKACSIDKEEETRLAQEFRQKFGPFDFNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRL0</accession>
    <name>A0A8B7YRL0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pancreatic lipase-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110982078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095918.1">
        <property type="nucleotide sequence ID" value="XM_022240226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRL0"/>
    <dbReference type="GeneID" id="110982078"/>
    <dbReference type="KEGG" id="aplc:110982078"/>
    <dbReference type="OMA" id="ASAYPCT"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034638109" evidence="5">
        <location>
            <begin position="23"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095918.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="39445" checksum="1D6823D472F467F2" modified="2022-01-19" version="1">MGIVANVLVLALGLLVAAANEAVSPNYVCTDSFSPVTYPEVGTFTADLPCHRRGFPPQHPNKMGTTFRLYTRKNPSSPTVISTSSLGYPFSASNPTKFIIHGFTSNGETSWLLKMKDELLIKCQQTMGVYSFQGDFNVIGVDWKKGASPGLLPDYCQARQNTRVVARQIRNLIKKMQSSFWAFDLDDVHIIGHSLGGQTAGYVGEEFGGKIGRISGIDPAEPDFQGDQTGCRLDPKDAKFVDANHCSMLGIFQPVGHVDIYPNYGTHMPGCVSWPDLLEGQCGHGKAIDYFIDSINNNCGASAYPCTWQTGQGQGCKYSGQSGVSGVKFGYQANQTPSREWSLTIAELKAGDISNDYNPELVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRQ5</accession>
    <name>A0A8B7YRQ5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial-processing peptidase subunit beta</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110982099</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022095958.1">
        <property type="nucleotide sequence ID" value="XM_022240266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRQ5"/>
    <dbReference type="GeneID" id="110982099"/>
    <dbReference type="KEGG" id="aplc:110982099"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034761807" description="Mitochondrial-processing peptidase subunit beta" evidence="16">
        <location>
            <begin position="23"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="17">
        <location>
            <begin position="62"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="18">
        <location>
            <begin position="213"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022095958.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="53490" checksum="BD2F0E2306F53E0C" modified="2022-01-19" version="1">MASWLGRSSLLLARISTSPALARPASVTVGRRYQSTQSAAYQQTLVNVPETKMSTLSNGFRVTSEDSGMPTCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKNRSQMELELEIENMGAHLNAYTSREQTVYYAKSFSNDLPKAVEILSDIIQNSTLGEAEIERERGVILREMQEVETNLQEVIFDHLHATAYQGTALGRTILGPTENIKSINRNDLVEYISTHYKGPRIVLAAAGGVNHDELVGLAEKHFGNLGIDYENEIPVLPPCRFTGSEIRVRDDSMPLAHIALAVEGVGWAHPDNIPLMVANTLIGSWDRSCGGGANVASRLAQAAFEGNLCHSFQSFNTCYTDTGLWGIYMVCDGLSIEDMMYHAQSEWMYLCTSVTESEVTRAKNLLKTNMLLQLDGSTPICEDIGRQALCYNRRIPLPELDARIEAVNAKVIRDVCSRHIYDKCPALAGIGPIEQIPDYNRIRGSMYWIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YT92</accession>
    <name>A0A8B7YT92_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pancreatic lipase-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110982077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095917.1">
        <property type="nucleotide sequence ID" value="XM_022240225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YT92"/>
    <dbReference type="GeneID" id="110982077"/>
    <dbReference type="KEGG" id="aplc:110982077"/>
    <dbReference type="OMA" id="ETINNDC"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="39"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022095917.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36624" checksum="A8977D93D0F22C98" modified="2022-01-19" version="1">MSSEVNPDCVCTGNFPPVTYPEVGTFTADLWCHRRGFPPMHPNQIGTTFRLYTRKNPSSPTVISTSSLGYPFSASSPTKFIIHGFTDKGETSWLLKMKDKLLKKGDFNVIGVDWEKGASPSFIPDYCKARQNIRVVARQIRNLIKKMQSSFWAFSLNNVHIIGHSLGGQMAGYVGKEFGGKIGRISGMDPAEPDFEGNQRGCRLDRGDAKFVDASHCSLFGIFQPVGHVDVYPNYGTHMPGCTSWPVLAEATCGHMKAIDYFTETINNDCGALAYPCTWQNGQGQGCKYSGQSGVSGVKFGYQANQTPWSKYGLYTRMTNQNSPFCNPNSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YU66</accession>
    <name>A0A8B7YU66_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Octopamine receptor Oamb-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096844.1">
        <property type="nucleotide sequence ID" value="XM_022241152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YU66"/>
    <dbReference type="GeneID" id="110982606"/>
    <dbReference type="KEGG" id="aplc:110982606"/>
    <dbReference type="OMA" id="NMPVERN"/>
    <dbReference type="OrthoDB" id="2105199at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="48"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022096844.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41341" checksum="DB7F882D572F6B30" modified="2022-01-19" version="1">MSSSPEQQSLDSHNATDFDADIVVYKYHYEVHIIAAVLISGAILGSIGNCFVIIAVALSKKLQTATNVFVVNLAVADVTTCLFTPWQAVAILGGDEWPIPRAPWLCTASAFVVVTTIGCSINNLALIAINRWVGITKSRFTTHRICTSRKLALMVIFAWAVPLCCALIPVVTDVGELGYEKLYKSCTWVRSNPYSSYYSTFVTAINYPIQLFAIVVSYTSIFCYVRKTSQKMARADAPSISDKVSGGVSSRAMRKKLWKRQLDVTKNLLYIVLAFVFCLSPYFVSIISSAVWSYRLAPWGAVVLFCNSSVNPIIYATSHPDFKVAFKHMLRCQNMPVERNGRYRSTGNTSLKTWRVVQQMPRTAPLSGPEAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YV14</accession>
    <name>A0A8B7YV14_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 248-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110982303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096325.1">
        <property type="nucleotide sequence ID" value="XM_022240633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YV14"/>
    <dbReference type="GeneID" id="110982303"/>
    <dbReference type="KEGG" id="aplc:110982303"/>
    <dbReference type="CTD" id="55069"/>
    <dbReference type="OMA" id="TLFCYAI"/>
    <dbReference type="OrthoDB" id="6329605at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039493">
        <property type="entry name" value="TMEM248/TMEM219"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039587">
        <property type="entry name" value="TMEM248/TMEM219_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16002:SF4">
        <property type="entry name" value="TMEM248_TMEM219 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16002">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 248-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14940">
        <property type="entry name" value="TMEM219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM248/TMEM219" evidence="6">
        <location>
            <begin position="9"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022096325.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33810" checksum="0D59C422C678B423" modified="2022-01-19" version="1">MAYKPIENLKGHVRSRPPVVIFIACMFLLALSLIILGYYFQHDVPNYDISEDWNSFLEELSSVDFCLALNTSTVTSAVSTVKTNTLDNTSISLTTDPFPVGDYEEDWAMKRNVSVSVMLMIDPSVHMAKTVANITMMSSLVPASMLGVKGSEEMISVQFELPQPLKPEQCKDPATCQIAVQTCLVLIGSPSVFPSTKQPVSCNTTDSHHENSTAWMNVRPTGRAPKSWCKHGAVAHAKHKFDPRLTVMLSSAEQSIINLHLMYTSYFMFVMVIMWVCYALVKGPPTKMRNVHNTGIEKKSQPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVS6</accession>
    <name>A0A8B7YVS6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022097414.1">
        <property type="nucleotide sequence ID" value="XM_022241722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVS6"/>
    <dbReference type="GeneID" id="110982923"/>
    <dbReference type="KEGG" id="aplc:110982923"/>
    <dbReference type="CTD" id="9960"/>
    <dbReference type="OMA" id="KYWVKYL"/>
    <dbReference type="OrthoDB" id="21192at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF19">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="150"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097414.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="59024" checksum="4F18EBEDE886C14D" modified="2022-01-19" version="1">MECPHLVNSVTAGVTAMPVTRKSNNGETSTNWVCAVCRSSKSPWMCLSCGTITCGRYVNGHSKKHYEECQHCVCISCDNLSVFCYECDETAVNDTKAGTVQQVRQILQDIASAQFDNKRLKSSKEQVTDSDEEGPPRKKLATNNVKATIPGLRNLGNTCFMNAVLQSLSNIHQFCCYFKDLPAVELRNGKSAGKRIYNTRNLKHDDVSLVEEVRKTLCALWQGGQSAISPDSLFSVMWKIFPRFRGYQQQDAHEFMRYLLDRLHTELQGTLWPGNPRRQTNGTSTIVTFMFGGLLLSQVHCVVCESFYKKIDPFLDVSLDIPHRFRSRSKSKDGSRVCRIQDCLQSFTEVEELAESEHYMCTNCQKKQPSTKKFWFRKLPNVLCMHIKRFQWTGFLRSKIDVFVQFPLRGLDLRPYILKPEELPDSDSTVYDLKAVVIHQGSGAGCGHYVAFAKNDGQWFCFNDTTVSPVHESVVLRSKAYILYYTRRKATQDDCFQLVTALQEELRSEGNVRLSNTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ46</accession>
    <name>A0A8B7YZ46_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amine oxidase</fullName>
            <ecNumber evidence="10">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983581</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-acetylputrescine + O2 + H2O = 4-acetamidobutanal + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:70283"/>
            <dbReference type="ChEBI" id="CHEBI:7386"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58263"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:70284"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>benzylamine + O2 + H2O = benzaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59424"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17169"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:225238"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:59425"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022098628.1">
        <property type="nucleotide sequence ID" value="XM_022242936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZ46"/>
    <dbReference type="GeneID" id="110983581"/>
    <dbReference type="KEGG" id="aplc:110983581"/>
    <dbReference type="OMA" id="PIHWAGT"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="11">
        <location>
            <begin position="287"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="35"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004362"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045409"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049354"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049430"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01593"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_022098628.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="70485" checksum="694D3CD9FE7A9EB0" modified="2022-01-19" version="1">MTSSKKDVIIIGGGISGMSAAKLLHDEGLEVLVVEARDRLGGRTLTQVDPSVGYVDLGGSYVGPTQNRLLRLAKELGVDNYRIKEDERLIWVDNQKGYPFRGTWPTFWNPFINLDLNHAIREVDRLGDMIPVDAPWDAPNAEELDSMTMKEWIDKNCWTENGRRFFSACVRLIVTMDPKELSVLFYMWYIKQCGGFLRNLMTDNGGQERKFVGGSQQLSIKIGERVGKENIKFESPVSQIDQSEEKVVIQNIHGEVFESQFRNGRRFFSACVRLIVTMDPKELSVLFYMWYIKQCGGFLRNLMTDNGGQERKFVGGSQQLSIKIGERVGKENIKFESPVSQIDQSEEKVVIQNIHGEVFEAKYVIIAMAPSMTQRIHYSPPLPPKRNQLIARAPVGSVIKCMVYYNKQWWKDRDFCGSTFNVDPASPMVYSLDDTKPDGSFPALICFVAANKAREFCSISKEERRDRLCKAYFNAFNGAEEALHPVNYVEKNWMEEQYSGGCYTATYGPGVLTQLGKELRKPFGRLYFAGTETATHWAGYMEGGIQAGERAAREVLHRMGKIAENEVWQDEPESKEVPALPFHSTFFERNAPSVPGFLKFLAHTAIASTAVGLFVAWRAKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ68</accession>
    <name>A0A8B7YZ68_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proton-coupled folate transporter-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110983217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022097982.1">
        <property type="nucleotide sequence ID" value="XM_022242290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZ68"/>
    <dbReference type="GeneID" id="110983217"/>
    <dbReference type="KEGG" id="aplc:110983217"/>
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    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS"/>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="129"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <begin position="438"/>
            <end position="458"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022097982.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="54539" checksum="E8BB312BACABDFB2" modified="2022-01-19" version="1">MGVLRMVTVEPVRLLFTMALAMHSLASRDLVHRKVCLSRLNETMCGKGEGSPDLAGNTSYSRAIQEDVASFCFYLDICANLLGILVSSVFGSASDRFGRRGLLLLPSLGLILGSVSCLMQSYFLLLPLYYMFFSSALTGLFGFYQASYIATMSCICDITDHSDRSFRLGVMESMGLIGGPIGMVLVSPLLHTDYYAVVFFIVILSQVAVLAYVHYWLEETVDVRAFQDNSRDSGGVTSGQSPQSICSVVGWSLRRTLMIYVIWRTENRRQLLLINQTVGVLSSVGSSGEIDLTRLYTSKPPLSWAPFTLLAYLSVKDAVRGMILAVGMPLLYVHISHWSIRSDMILAMITLLSSSASLVLRAFASNTLMMMLVPLVGCLSGFPNTLISSIKCKLVDSNEFGAVFACTMLIQTICHLSGRALFQLLYTATLPIWPRLPFLVMGILLVTFLSIITYMWCLSGHLVKKDKMDARQQLINSYGGGEEETELSSSPKTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZN4</accession>
    <name>A0A8B7YZN4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110983209</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19369"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:11600"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16367"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.85"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022097965.1">
        <property type="nucleotide sequence ID" value="XM_022242273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZN4"/>
    <dbReference type="GeneID" id="110983209"/>
    <dbReference type="KEGG" id="aplc:110983209"/>
    <dbReference type="CTD" id="84193"/>
    <dbReference type="OMA" id="QHIDGIF"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19176">
        <property type="entry name" value="SET_SETD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1420.10:FF:000001">
        <property type="entry name" value="histone-lysine N-methyltransferase setd3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025785">
        <property type="entry name" value="SETD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044428">
        <property type="entry name" value="SETD3_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51565">
        <property type="entry name" value="SAM_MT85_SETD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="94"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="531"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097965.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="71926" checksum="9C05C0B3D160A8B4" modified="2022-01-19" version="1">MMGRKSRRKYNPDPEDTAKADKKEITALCSQILEIAGRPSHMVPAKQWEEFLQIHSLVEKIRKKQHDVSFENHNREEHIEDFLAWAHSQGIIFDSVTIHKFDSQGLGLKAVKEIKEHDPFVAVPRKAMLSEDRVLDSPLGPLIRKDRVLQGMAHVALALFLLMERQSENSNWKAYINTLPNSYQVPLYFTPEELQQLQGSPTYTEALKQRKNIARQFAYFYKLFQTQVDAAKLPLKESFTYDGYRWAVSAVMSRHNQIPSGDGSRLVTVLIPLWDMCNHTNGVITTSFNLQRDSCDGLALHDIAVGEQVCIFYGLRSNSHLLLYSGFVYPESECDSVSIQLGISKNDRLYAMKSQLLAMMGSADSTINLAVEGGDNPISPELIAFLRVFSMDEEELVIRMFDKNKTESLGRLIRPNCLVSKANELRVWTFLETRLSLLLKQYKTTVEEDVDQLSRTDVSANAKLCIQLRLLEKRILHNAMAYIKTRRKDTEELAEDATSYQEELELEEADKVAEVPDTSPAPITRLEYKTAIDSSSDSSSSNRNSSLSLQSDTSDDSVLKPASPIEELPETTSPLVTNGDSTTTCHSKVKVSGACTVDSLNNALNGISLKGDNSHPVDVGTESKHTAMSNCHSELNSSVADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0E6</accession>
    <name>A0A8B7Z0E6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110983817</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Preautophagosomal structure membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099074.1">
        <property type="nucleotide sequence ID" value="XM_022243382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0E6"/>
    <dbReference type="GeneID" id="110983817"/>
    <dbReference type="KEGG" id="aplc:110983817"/>
    <dbReference type="OMA" id="SVWCMIC"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034528089" description="Autophagy-related protein 27" evidence="19">
        <location>
            <begin position="25"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="20">
        <location>
            <begin position="31"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022099074.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26346" checksum="338FD5AE4CB2080A" modified="2022-01-19" version="1">MELQFLSLVTLVLLLVMQCEEVLTATCKKVDSCTCKFDDGSGVISLKTLANPAGGQPRFNFTQATRDSYFYAYNPCNSFKWNAPCGDVAVCQMSSDGKEIFDAGNQPTASFDAEGTTITYTASARTTTVNLICSPSATTPVYEPQGEGAVQEKYAINLTSNCACKNGCLPGGLSPGSALCIIFSVLVILYLVVGVLFLKFVRGAEGKELIPNYEFWKELPLLIKDGVLFVVHGCKSDSNNYETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3J4</accession>
    <name>A0A8B7Z3J4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Guanine nucleotide exchange C9orf72-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110984370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100204.1">
        <property type="nucleotide sequence ID" value="XM_022244512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3J4"/>
    <dbReference type="GeneID" id="110984370"/>
    <dbReference type="KEGG" id="aplc:110984370"/>
    <dbReference type="CTD" id="203228"/>
    <dbReference type="OMA" id="QPFYTSV"/>
    <dbReference type="OrthoDB" id="10252077at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027819">
        <property type="entry name" value="C9orf72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31855:SF2">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15019">
        <property type="entry name" value="C9orf72-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51835">
        <property type="entry name" value="DENN_C9ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022100204.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53768" checksum="382352EBE65C1422" modified="2022-01-19" version="1">MASFSDEEVATISKRVVVLVDSEMHLQHPQECRVNQALPDTADCPLYALVLCCWNNILGPHAKCIWLTEGKEQRFTANHIAYLSTHTLTSCEQPQSTIDTKVLILPERGIVATVFLFSGHDYDEKTIFALSLVIPYEEYRWYLPLHELCVARLTTMIRRLRVLQEKNKDENNDSSLMAFSDEVPSFIRVVTLLKTHGLPSRVELGDTVFAPGHAKQLDDQFTKIAIASHLQTCGCSIILGNTAADVNMMISTLALFLSPTERHCCLYLDDVPRVYQKDVLIQGFLKNSISLDDYLRVIMTSQYPTTLIDLVTLEVKQTLHYNQHAYRRHEATSQELQCLWLNSDEPLRYSPVVHFSNKPEAETIVQKFWKEINRLQDNCRIRETYIEEFLRLLDRKAVSLIKYVEEETNRGTKPSRLVLKRLKSDLHLIPEGDFRIVIAMAEKLQPGVYTLVCGNPALPRDSYNDLVTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3W7</accession>
    <name>A0A8B7Z3W7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110984436</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110984436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100334.1">
        <property type="nucleotide sequence ID" value="XM_022244642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3W7"/>
    <dbReference type="GeneID" id="110984436"/>
    <dbReference type="KEGG" id="aplc:110984436"/>
    <dbReference type="OrthoDB" id="5952652at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022100334.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="24787" checksum="F23DD043EBE56AAF" modified="2022-01-19" version="1">MIARFPNFPIYLWRDTITNCRNHILKTLKVFRFEDAFIKIYPKGKGICPSDLILTYAYYFEHDRYSWHIDVEKKSLAKYNQRRVPAGFEIRRNETEPGFLQVTTHKSYIFMFRGFCIAKRYVGTLPANCKMYENTTNFQHFNAIHDHLKTWCAPGRGRAKCAQLIESHYQNFARYYRSGMMDLDLQRVYAVEEAAKRENISCPTVFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4Y4</accession>
    <name>A0A8B7Z4Y4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984639</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100699.1">
        <property type="nucleotide sequence ID" value="XM_022245007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4Y4"/>
    <dbReference type="GeneID" id="110984639"/>
    <dbReference type="KEGG" id="aplc:110984639"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100699.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="26395" checksum="57A0229995EC4E2B" modified="2022-01-19" version="1">FLVGSLCHHLGRCTNNLQPVTHLNFRGAGFGFDCFRCLHLTRSSLWISQPSRQAVDSLLAILGLAEMIISIVTASMSCYGVCVCCNSYTPVTVQCVPQPANALFVPMTTMQQQQQADMNVQKQLQQQPVRMPAAAKGTSAGPQCASATNYNVAPTQQVANFPQGNACAPQPVGGPAIQAPQPVNVAPQPAGVAPQQLVVTVPGQDPPKRPAGAGMQTAEGPQAFVNQAGVAETGGSEHFHHDDKKGLLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5G4</accession>
    <name>A0A8B7Z5G4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC110983558 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110983558</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098575.1">
        <property type="nucleotide sequence ID" value="XM_022242883.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098576.1">
        <property type="nucleotide sequence ID" value="XM_022242884.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098577.1">
        <property type="nucleotide sequence ID" value="XM_022242885.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983558"/>
    <dbReference type="KEGG" id="aplc:110983558"/>
    <dbReference type="CTD" id="85459"/>
    <dbReference type="OMA" id="GMPMFSD"/>
    <dbReference type="OrthoDB" id="6359887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046599">
        <property type="term" value="P:regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553:SF26">
        <property type="entry name" value="ALMS MOTIF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21553">
        <property type="entry name" value="ALMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1269"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1618"/>
            <end position="1701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1798"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1874"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1971"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="950"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1270"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1672"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1882"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1924"/>
            <end position="1934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022098575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022098576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022098577.1"/>
        </source>
    </evidence>
    <sequence length="2018" mass="225397" checksum="85A709C5540FCFBD" modified="2022-01-19" version="1">MPTTGAKSQKTGYHLSPNEEAALIKREKERRRKLRIQQVREQERNFASKVRSNVNKKKDEELKNLALHMKKDWEEEKKEKTDALQKIVERSLDSIGDGHRAASNQPPLAEIRAAQALKDQHSAIQRYNTALKRQQVEEEQQYLKENAHIIARKSALQAEKIRAAKMASLPPPVKDPLEDLDDVGKENKIVIVTSGFSTSHYHLKGEYVEKAEPEEQEDARLAAQEEERRAKEDKVETEREEKERQEKACLRHQHARKQELLHQDYNKLMEELGHMEQADRRRRQTIVANIPHQVFQPPHKRLEDKQEEQQKLEQAFEDMYMANTDYTGDLILALEPKPQRDTDLDVTVDSVSDDVGISLQPVPILPADRDDGGKRLPQGLDEESEEEAEKTIAEEKPKQPRAPLKKLMDRIKSQREELKKKVVLEVPSPERHPREELETPSSSRDLSTEDAFSPSPEAAQEESESDRGTLDTLESGTLSEDTNKLEEKRTLLHPLEEAAKIRSVTKVPEVELQKKAQEDIIAKEDEQRLRLAEKQLQEHMDHRDHLQMLQDNLLQRQRMLQQHIGEQERLHREQLQLQQEQFGKQQPGLWNDELQPQLNEPLENQHPQSHNVHAIQRLIRQLQISDQQRQLQRAQQLQVTQQQQQTQDNGQQQHDLTQYQDLPNNLLRQPNLMSKESSRQKQHLQQQQVEVNTADFQLPRQRISQLMERERSTQDLTVKPAVELMDPTTFPKSVSGLEQKRDFQARQIPVTVEQGHGEEWLRQHLQDTVKTAVSSQLTADQAGRKLPSRDTLQEAQLQLEQRRERLMQLYPELQLPPYEPYIKNKPTPDSTEPMTDMVTDTPMYQGAQIVRDAGLGKDIEHSDAVQVAPSVVPISAAESFVRQQGASQMTGVSTTCDVSAAGVSVTGVSSVSKPEAGLSSGADSASAPQLDVLKQTAHSTASGLPLNEMERKLEQHRQQLLKTWQQLQQQQQQQQQRILDKQKILVQRIGQQRQEQLSRQQGQGTVSEGIPQNVIISPPGTQVMMTSQPILHDVMSQIPPGIPRALSSTIRTSHPVPPDVVFLQCGTQDVIASEPPEVTTVHPDAQPKVATRELGVPHIKGVGSPEFSQQVGQTLSKTKESSDGPSPSRAVYKLPSMTLGKTSYHFDPTLDVAGKSVERELPSFHELSLESSAHLTENSDHQPFEVTENQDVPAHGQSGMGIAQHMQQDWGSIFVSGSDPNKQVERNQSALPSQRLAKHTRPPPSQWRLPQMTMEAGPHELSTILEGESPEGKHLSRGHQELNPLASTPHKTSPFLLETSQQGTQASSSPFYLGEHASVKSDPSGKASQVATPVGQVSGINCSKTLTIAEITQTPNVDSHSQGQVDTSRPTFVPSFAMDVGRGVLSYPSSNVMTEGPVATVSASAASSIPVASSHTTPIPIPNPANIHIASPVTDTEEVTTQPDSTISMLSEHTLVNSLQLSDESVEQFLALSASESSTSDSASSTSARYQVQMLGSDKRSTKSPVIKNFVMDIPSRSSWKSSFEPSIPPFSQSGAAATEVTLPSLPTAPRQSIHSEDYNLGPVSPQSTWTDTDTQSGSYLAGGAPFFPMFRGSDIPKDGMSMFSDVSLSHYNTSLESGPTILPISTVDPGQLNRRASPSGESEQWFMPQQKLDNSELHQPDRGSTVKHSRERVETGKETLESETDVSVDTPPSDDESSKLSYAGALVEEPHDPSGAMVDDTLQEAMRNIAVSESETSKETGIIEDPDLTLISLNSTLTSFGPPDDSNDSIKQRQWVSEELGSDSLVSFLHHEEEMKLESPARSGLDQSKAVGTSSLMAEDQVDLTGGTASSEDRSISLQEAFMRHKQSFIRSTQSRQLEVKVHAESHQATAFSQTLDNWKRSRGGKIHRPSNTRTSKSPSKGPAVRGKRSGTGPTRHGQVSMREIEQTKDRSKITRTVTSSDRKAAERDMYLRNIRLYNQLEEVQKWKLTQQRKRDYAANRQRRKEFGQKLQARFKLTKQTGKSPSLRDAGTNGSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5M5</accession>
    <name>A0A8B7Z5M5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Scavenger receptor cysteine-rich domain-containing group B protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110984765</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100939.1">
        <property type="nucleotide sequence ID" value="XM_022245247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5M5"/>
    <dbReference type="GeneID" id="110984765"/>
    <dbReference type="KEGG" id="aplc:110984765"/>
    <dbReference type="OMA" id="VACESPH"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034342966" evidence="12">
        <location>
            <begin position="25"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="597"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="141"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="248"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="365"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="482"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="632"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="165"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="178"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022100939.1"/>
        </source>
    </evidence>
    <sequence length="764" mass="81961" checksum="099A7E549F10CF8F" modified="2022-01-19" version="1">MDQTGAVLQVVAAVFILQVFTTWAAPGSDLRLVGESSSYEGRLEVYHESTNQWGTVCDNSWDYPDAMVACRQLGFTAVTTSLYHLDGASAPILLDVVQCVGHEGRLAECSHAGWGIHSCTHSDDVAIQCGYDNTYVDPMPIRLVGGSVRSGRLEVYLDGAWGTVCDDNWDLADAQVACQQLGFTTVANYLLPAIEGATGPVHAYYIGCQGSETHLGQCVQRGGWGSRYCGHDEDVSVACESPHMETSLRLADGSRPNEGRLEIYHNGEWGTVCDDYWDHHAAAVACRQLSLGSPSPLTGVYIPQGAGSILLDDVMCQGWEARLVDCGHLAMGSHNCGHHEDVYLACSVEDFSNIATMPAPDSYTLHLADGLSHYEGRLELDINGVAGGICDTDWTLRDAVVACRHLGFGTAIREVPDGTFGVNYGGYYWRNNVTCSGEEATLQDCSVGNLGLGFCAHGGHDVGVSCTGPFIGEERGMRNAAVRLEGGSNSAEGRVEVLFNGEWSTVCDDGWDDIDAGVVCRQIGFMGAENSHHYIDGLPVASGPILLDQVRCEGDEVTIMGCRHNGLHTHDCVHDEDVVIKCYHNKVHDWKLGGGKVFGIVTVVCVAISLGFFIIRRRMQLEKLRNLLVVPESEQPEPAEGPGPGGLTSPRPYPVQPAYPQLQLRPPLSQPLSQPPCGPGLTAAIPPLPPVGFPDPNPLPASYMTTTSGADGVSQLPVYLPSPVAVTSMPPVQDSLPQVQGTAPGQLHPIHGRVHHTSSSHSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5M9</accession>
    <name>A0A8B7Z5M9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 255B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110983593</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM255 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098641.1">
        <property type="nucleotide sequence ID" value="XM_022242949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5M9"/>
    <dbReference type="GeneID" id="110983593"/>
    <dbReference type="KEGG" id="aplc:110983593"/>
    <dbReference type="OMA" id="GLANCMA"/>
    <dbReference type="OrthoDB" id="10034004at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028014">
        <property type="entry name" value="TMEM255"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33721">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 255B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33721:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 255B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14967">
        <property type="entry name" value="FAM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022098641.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="29280" checksum="85FAF22366438F45" modified="2022-01-19" version="1">MDKILADAKRRRKIAAFSCLVLIALSVVQLTIGVVAYQMIHNINAGSFWAVGGLLLGSILALVGVYNKQEGGCWMKTGTVCMGLGIVLAFVGAIIDGVTASAVSKVDILKCNHSDTGLANCMASAGCEKSVSMLSTCYCCYVTSQREASCAFQSVSLSEIPSFFSGVKSCADVSSYINLLWASVAFLTFSLIVGVVVTAMVSGYKNLVAQIPRTYIQTTVQRSPAPAYPTSSAYQPVVSPTPTPTATPQHDQIQKTSRPIPAPRNSRPPPYAPPADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z600</accession>
    <name>A0A8B7Z600_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PI-PLC X domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110984824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101063.1">
        <property type="nucleotide sequence ID" value="XM_022245371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z600"/>
    <dbReference type="GeneID" id="110984824"/>
    <dbReference type="KEGG" id="aplc:110984824"/>
    <dbReference type="OMA" id="PWPNTRN"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08616">
        <property type="entry name" value="PI-PLCXD1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042158">
        <property type="entry name" value="PLCXD1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022101063.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36135" checksum="1E15B8CE2B57E53D" modified="2022-01-19" version="1">MAAAGDSTNVENSKIENEEDYSDWMSKLPEKLLCEPLKNIAIPGSHDSFSYTLDLNTPVSPSSPDTVRNLVSAFGDMAKKIVYKWSVTQSLTFIQQLDRGIRYFDLRVSTLKGKAELYFVHGLYGAEVGTCMCEIKSWLDKHPKEVILLDFNHLYEMDSTDHEQLVATLLSVFDSKLCPVIDTETAALNVLWEKGWQVLVFYHHPVTVGDHPELWSGSYMPSVWPNVTEAPKMVNLLEAHFTRGRPQGKFYVSQGVLTPTGTTVLQYISRSLQDVFALIAIKNVQYFMKDKGIGPRGLNIVIADFVELGDFIPSVLALNHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z611</accession>
    <name>A0A8B7Z611_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Receptor-type tyrosine-protein phosphatase alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100235.1">
        <property type="nucleotide sequence ID" value="XM_022244543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z611"/>
    <dbReference type="GeneID" id="110984383"/>
    <dbReference type="KEGG" id="aplc:110984383"/>
    <dbReference type="OMA" id="ENMPAKQ"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF534">
        <property type="entry name" value="LD27988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="82"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100235.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24633" checksum="65202810FB80C472" modified="2022-01-19" version="1">MTSIVMLNAMDLSDSSCPQYWPDEGSQDHGLFTVTVANVVKFDGYNVKLMKLEHRRQKRSQYLKHYQVTDWPVNQEMPKSPSTLLHLILTVEKEKEKGKHSPILVHCIDGLNRSGVFCVLKNSLDRLHQDDTVDIMQTTKVLRLNRPNMLNDLNLYRFCYDAMLAYVSNPDEFRVDIMPQPVYENMPAKQEEKATPEESIYQNVEKPPESSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6M5</accession>
    <name>A0A8B7Z6M5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Cornifelin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110984499</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100439.1">
        <property type="nucleotide sequence ID" value="XM_022244747.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100440.1">
        <property type="nucleotide sequence ID" value="XM_022244748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6M5"/>
    <dbReference type="GeneID" id="110984499"/>
    <dbReference type="KEGG" id="aplc:110984499"/>
    <dbReference type="OMA" id="INDCCTV"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100440.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17524" checksum="73FF0DE96CF9C1AE" modified="2022-01-19" version="1">MDPTGAVVQQPRYEQMVAYSDADVAVQMPPAVPMGTVVTSQPTTTTTIINIGQSNFLYPRGIPRDWSTPLCGCFEDCVGCLCAFFFFPCYECHVATKMGQNCCTPICVPNGTMVMRAHVRGRHNIQGTLINDCCTVTFCTPCALAQLSREIDNMQSGRAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7R2</accession>
    <name>A0A8B7Z7R2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase</fullName>
            <ecNumber evidence="14">2.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110984709</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81643"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="Rhea" id="RHEA-COMP:19720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="ChEBI" id="CHEBI:231970"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-O-[N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81659"/>
            <dbReference type="Rhea" id="RHEA-COMP:14417"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:139598"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81660"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminyl-(2-&gt;6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11136"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:140764"/>
            <dbReference type="EC" id="2.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11137"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022100835.1">
        <property type="nucleotide sequence ID" value="XM_022245143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7R2"/>
    <dbReference type="GeneID" id="110984709"/>
    <dbReference type="KEGG" id="aplc:110984709"/>
    <dbReference type="OMA" id="HWKRLCL"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941:SF2">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022100835.1"/>
        </source>
    </evidence>
    <sequence length="462" mass="52733" checksum="22B13F4498BD1B52" modified="2022-01-19" version="1">MDNCTNSRILLFLLLASSAFLTLLTIFKLDVASTQFYTAAKLVQVDAVVRFHGNGGVIKGTNYSTETEQANARSSKQQDFLQGYLIEEQKFIRNMETHLKSLPSESGSTLILEGILKRSTAKSRAWWSDGKVGIHDRQFIDYMKCPTSLRWKMLLDRYTKRKFVPETPILAWNEHFSRDEYARLSRFHGIFGWKDLKEKEIASALTAFNSSRSKYLFDDRMISGKTPNNISCIKCAVIGNGGILKGSKKGKEIDAHNYIFRVNSAITKGFEEDVGTRTSFYCFGIITLSNTLAEGLSTGFLQLPNDKGIRYIFFADNPWAYAFLAAALNGKSLPLSSDGRGRLPPKFPKKLTANDVKLVHPDFQRYLKYNWVNSSQRDLLIHRPTTGGIMLLLAIHTCDEVSAYGFAGSYDEYSDHYYDKIFKKHKTFLNHDNQAENELWKELDKRRIIRLYTRENTEKSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9D0</accession>
    <name>A0A8B7Z9D0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Uncharacterized protein LOC110985028 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110985028</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101414.1">
        <property type="nucleotide sequence ID" value="XM_022245722.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101415.1">
        <property type="nucleotide sequence ID" value="XM_022245723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9D0"/>
    <dbReference type="GeneID" id="110985028"/>
    <dbReference type="KEGG" id="aplc:110985028"/>
    <dbReference type="OrthoDB" id="5987693at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="671"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="645"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022101414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022101415.1"/>
        </source>
    </evidence>
    <sequence length="731" mass="81555" checksum="55D67CF7C3B46705" modified="2022-01-19" version="1">MWWSCPQFYQERTQGFFFLREVERFYRKCKEDGSPTTLMAASCIGKQPKKDVWVLSPSLQLDSNGVEISTEDQTFYWVDKLLPVSATSQLEVPSHFNVLHPVDVLRDVFQALSDTLHENAIAGIFTVASVCLSLHYETVLELFKCCPIPIIIGDINTGKTTSCRMASRMTGAKNSLLGYTRERFLPKATSGSSIPVILDDAEPNAIRGLMTKYFNGGVDATCSFESTPKCCPIISANWFALSKLAGSEREMTRAVIIPFLKTERRRSEDQFQAESRRHELEDVAVHCLPLLVSIASDLKKEKSHILQKCRVFVARILSHLSDADDRLHLTYGILLFVAQLLLQKANIEKLGPEQAETFLQTTVMKYGIEQFQVGNAMLNGLPSPTKTIADMAKLIIEAVQVCHIGELLTAVNPRVDVGGTIGLAFHLVTLLNILFAHGIDHPSKDICRQAISADPMMSGVQVYLNVERHHDIISRGGVKATGPRNRRGIWMPYSRFSQTQLREIESVFQIQTGTGAQVHVIGMQEDIQRNAEERSERGEENNAEDVMETDVEMVDVSDPVEKNSTELNETKEHREPAGPVTLESAHRKLFVDETQSSTASTNSTFEEPSSASTSIAHNSQRDAVNEAEVARNKKDRASRKRKYAETTTTQADGPSTLTLNTAESQRTTGDEGFCRTCLRTAPQRTKSRQNKKIKWISCGNCCGWFHQECLGMNLSNKEAEDLVFTCSKCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9R0</accession>
    <name>A0A8B7Z9R0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110985588</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110985588</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102408.1">
        <property type="nucleotide sequence ID" value="XM_022246716.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102409.1">
        <property type="nucleotide sequence ID" value="XM_022246717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985588"/>
    <dbReference type="KEGG" id="aplc:110985588"/>
    <dbReference type="OMA" id="IHQADET"/>
    <dbReference type="OrthoDB" id="9936560at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042417">
        <property type="entry name" value="PALB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031920">
        <property type="entry name" value="PALB2_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14662">
        <property type="entry name" value="PARTNER AND LOCALIZER OF BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14662:SF2">
        <property type="entry name" value="PARTNER AND LOCALIZER OF BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16756">
        <property type="entry name" value="PALB2_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Partner and localiser of BRCA2 WD40" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102409.1"/>
        </source>
    </evidence>
    <sequence length="1307" mass="142912" checksum="C65C421C7D84D980" modified="2022-01-19" version="1">MADSSKASHKHELRQRLESMKRVYARTLRKVEKSEKAKRTRSHVHRVIAEQKQVGSSDASPSCTHSLRRTGAHQRPEESSVGAGALSEESVTNVVRKQGGPKSTMTTKRMQRKRRSVSFSIPKENASIQTSLGGVHVEITDSCLETSEICHEQQTKKTSPKPFKDNFVQAPAPSFLSCGLGSSIDNDRAIGTGGDRRQAEEVTLVPESQLTELSNTSFDERGCIRGTAISHLKESVTSGCHRNISRSGNDSQSSVQSDSHLHGAILQDIKELRPSEQPPQDTTQPNSEGTTHSGENDTENSCQNLTEVRTKRAGRKSRRRSRVPRQLTASDISFKEVVESQSTEEGSHTWIEGLMYPAEYYVRHTRSMTSSQCPQSQSNFDKADSQRYLDRDTTGMREKVISTENSDTVKDLCIREIASLTRTAGGKTLTSFGSVPESESDSVRSQLSESLLTVSAVQSMQKKTYKKPSDSVKSVRGSRNQRLQRKCRFNLVTSEFKTDTSRDLSTTVAAEGCYSSDALCTDDTISASEESARSVEGITSNKFLPDLPPACTRSDSTVKSCKDFCAVELLRGLHKAKLSQTEFALPEEDFGTLMLVKLQSNCAADTSLHWRNSENEQDGRVDHDVEKQFKIRDVTKIDCQAANKTKLGCESCAPSALTNVVSYQTVLHGHTDHARSGSSDGGEVAENFGMKTIAAGLDAPKCCHQGENLTTSPIQDLSPVSCKVNVCAKTASRNTRESQGRTILHSQLSPSQFHKDCSMAFPNPGCTPGWSPSCSPDADHRVHSKGDSPLAPCNKMMGEDLQRHQTGDSHKRLSHTECKATDKGKPSAIKSGNSKCNTSQCSPCSGLQLHVPDVSSQLSSKPAAVVCKSCTTECSTLNLTPAGGNVTPPNVIPEAAGSSSIDRRGNIQQTSPFAGVATATPPGRAEEPTTMSQCEVKISEDGDEVLGETEKSGRHELAFMGCVQHDLPWEATLTVTAITGGSMVMNEHNISLLAFLYQHTLVVWRSNLDTQEWQILKSWIIPQDEEFLCVRFMPCSKHNKVTLVVAGVFATCGIRMLSYDTVTEETQELDVDLAHSKEKPIQYVLCVTGEEGFAVAVKDNAKSALFLVHTCIESRNVQTVKSWTGQETSLTALLQVEGVKGMLLASTAHNNIMLWNYASGELIKEIPMKCVDSGSHTVCLKATAESGLLFVVIIFHDDVGKEERRCSKPIGAAVVLNPLTDKMAKLMEYQTSMEHAHANCIDCAVSKNTLLAKLSDGSLHQWEIFSGNLMNYSSSHPTNYSLRSAHLCGSQVVLQGSDQWQQVYYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZA15</accession>
    <name>A0A8B7ZA15_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl-CpG-binding domain protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102509.1">
        <property type="nucleotide sequence ID" value="XM_022246817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZA15"/>
    <dbReference type="GeneID" id="110985642"/>
    <dbReference type="KEGG" id="aplc:110985642"/>
    <dbReference type="OMA" id="VSPICKI"/>
    <dbReference type="OrthoDB" id="10072024at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00122">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MBD" evidence="2">
        <location>
            <begin position="200"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102509.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="46313" checksum="B637207EAC9B3FBD" modified="2022-01-19" version="1">MAEEGAAATLAATDLSSRSRSGSSSGSSESDVSPICKISPLVVPVSSSTRPLTPKKRHRAEMEEEARRQEALLAAERAKAESETKTLTSSDTTEEEQDLDEKRIPELEANVPAEAESTSPSTPSAEAETAAEVKVAPTETDHKRQPVKKRKAGEDSDGPDSVVNTPVKRRAAPKKTQVAKSPAAPKSPKTTPRTPPPQAVVTATGDEPLVPEGWRRVVTQRMQGGTAGRFDVYIWSPTGKKFRSRPQLHAYLEETGSSLSIDDFSFKHTGSSATPARFRKLTTPVKLEKKKKKTTPKKKTVGKSKVQKVTPKRGRPRKNSAGGTKSPGKQAVSKAKKGKQQRKVMKPPPDTGSKKASRAQQLQKLLVKINFQKPGDIREMSEDESSEEDSEDDFDPGTTEEAGPDVSDVSSTPSPPSSKKGRRHSSPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAR4</accession>
    <name>A0A8B7ZAR4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985383</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102057.1">
        <property type="nucleotide sequence ID" value="XM_022246365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAR4"/>
    <dbReference type="GeneID" id="110985383"/>
    <dbReference type="KEGG" id="aplc:110985383"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102057.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="12900" checksum="B3724EF0A0DE130A" modified="2022-01-19" version="1">MITVLRIAEELMSVDYRKWFSSRWLPPSDRSLSLVSVGTDSPPLPPPLLDELGKGLVLDQSKLSIPNLIERLQPILGDLLGNPADQGEATTVLPAPGSDNGNPSYQKEAKPPWTNLAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB17</accession>
    <name>A0A8B7ZB17_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Uncharacterized protein LOC110985449</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC110985449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102172.1">
        <property type="nucleotide sequence ID" value="XM_022246480.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102173.1">
        <property type="nucleotide sequence ID" value="XM_022246481.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102174.1">
        <property type="nucleotide sequence ID" value="XM_022246482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZB17"/>
    <dbReference type="GeneID" id="110985449"/>
    <dbReference type="KEGG" id="aplc:110985449"/>
    <dbReference type="OMA" id="LMKISAC"/>
    <dbReference type="OrthoDB" id="9976543at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042342">
        <property type="entry name" value="TTC22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="414"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="5">
        <location>
            <begin position="625"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="533"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022102172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022102173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022102174.1"/>
        </source>
    </evidence>
    <sequence length="762" mass="87878" checksum="B62F452B934C6211" modified="2022-01-19" version="1">MEGSIKPGLYHLPLPINHPSLDKDAIKMKLNDIESDLRTRKDRAEEFAILNIIGLLNFHLKRYKDAETNFRAILSKDGRNLNALANIQFLFKKVYRTVEGERFERKLKEYLSESTEEAIRNKARCRAEQAYAYACDMHTDNAGTERFIESNGIFHTALEIGGDWIETAEKDMWKFCMAKNAHKIFDKFCFGENHLQSRDYMDTAVNHFYEITQRDPGDSEYQCESWRHLGDIFRKIKNRKHCTSSHLPDCLKKFIEDPEECMKKARDTATSDISKARILARYANFVYSLRRHTNEALRLLDESIRLDDSDYNFYAFSTRGTVRLKFFKWKIRRFKEDSKRHSQPDQSVLKHALRDMEKATEIRNASWDLLNIAEVYHLLAEHTDESNETKRGYLEREFGYLKQAEDCEDGGRQAHVKRSLGRCLFDLGHYREAIERFNEALDLQPATSQYTGYFHELFRCYLCLLRSEPKVESSLDEMAESLRQAMEKYGSSTLLKYCCGSWRAEYKQELQIFVDYCRTIPHNEGLLKLLMANEPPSPLSPPPRQGGLLKESWESPEQQAGDGVAKKDGDSDNLGHQSPDSLGASSPASPDLAGAAASLVSGIKSMTIEDTSVGEARENISNKNIEYDFFVVYSKSNDKWVHEELLPKMETRNLKGCTDRTDSLAGSLVIESDLNLMKISACILLVITDGFETECQYYMHQALMLRKRCHAIFPIRRDQSAVPVELRDVFCCFDATSDVIRWDKLAADIKRQKDTAMRALQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB38</accession>
    <name>A0A8B7ZB38_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Membralin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110985819</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102886.1">
        <property type="nucleotide sequence ID" value="XM_022247194.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102888.1">
        <property type="nucleotide sequence ID" value="XM_022247196.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102889.1">
        <property type="nucleotide sequence ID" value="XM_022247197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZB38"/>
    <dbReference type="GeneID" id="110985819"/>
    <dbReference type="KEGG" id="aplc:110985819"/>
    <dbReference type="OMA" id="YNITIAY"/>
    <dbReference type="OrthoDB" id="6779347at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019144">
        <property type="entry name" value="Membralin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650:SF4">
        <property type="entry name" value="MEMBRALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21650">
        <property type="entry name" value="MEMBRALIN/KINETOCHORE PROTEIN NUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09746">
        <property type="entry name" value="Membralin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022102889.1"/>
        </source>
    </evidence>
    <sequence length="697" mass="78243" checksum="BF21FB386D91695F" modified="2022-01-19" version="1">MPPVNPQQQQQQQQQQQQPVNADAARNNNNNPNPLLNVRDRLFHALFFKIAITYARAFPPSVRRFFEFAILIKALTALFVLAYIHSTFSRTPINCLVDYQEVWPRDGILRVEIVHNRTSPQAFSIYNKKGRTDSQTSTSTETYEDDLNGFSRVPMFWEYPGKESTKEPDSVQPSADEANVTVDIMVTEKPVKNMQPFRETVSEFEMFTRAVWPADEYIMEYSLEYGFLRLSSSTREKLGIPVMVVQLDPTQDACFGDSLSRFFLEEFLGYDDILMSSVKSLAEHEDNKGYLRNVVTGEHYRFVSMWMARTSYIAAGFIMLIFTISISMLLRYSHHQIFVFIVDLLQMLEMNTAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILIVWVADQYDAICCHTNISKRHWLKFFYLYHFAFYAYHYRFNGQYSGLALITSWLFIQHSMIYFFHHYELPTILHQARIQLLLQRNQHGGMHGAGLNANLNLNLQDNIPPDIPADDAQATPQVGPQVGPQVNTNSNVNSVGTNIQDQAATVPSRHQAQAPAAAVPRVVNPTIWQFHIGSMLRQRVVVPAQATHRYPPNTGSNPPTTSPHVIVVNSNNSTGPPQSASISVTEQPINEQNSTASTSTEGQSNNVQPSTNKPSESLTESPTPSQSDSSSTLPVDKESPAENSTTTNVGPTLSNSLNGGTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBD4</accession>
    <name>A0A8B7ZBD4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sorting nexin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110985865</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102984.1">
        <property type="nucleotide sequence ID" value="XM_022247292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBD4"/>
    <dbReference type="GeneID" id="110985865"/>
    <dbReference type="KEGG" id="aplc:110985865"/>
    <dbReference type="OMA" id="LWETFLM"/>
    <dbReference type="OrthoDB" id="271164at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07623">
        <property type="entry name" value="BAR_SNX1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06859">
        <property type="entry name" value="PX_SNX1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000012">
        <property type="entry name" value="Sorting nexin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000016">
        <property type="entry name" value="Sorting nexin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="14">
        <location>
            <begin position="140"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022102984.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="58651" checksum="62F4D0137C05E5F6" modified="2022-01-19" version="1">MADREPPPLFDDDDQDEIQIDDKPVDKPDTKTAPAEEEDDDLFAGGGTEVSLDDDNLKEAEPAEAPPPKSEPPKSEPPKEDAPAELETEPTSPVATAPSVSETVTPKSVAKSRVTDEQDEVNEKKEAEVEEEEEEETDTFDMEIMITEPIKKGEGMSAYMAYKVSTKTSNPAFKKPETTVFRRFSDFLGLHQKLVDNHTVKGFIVPPAPEKSVVGMTKVKMSKGQEEPNSMDFVEKRRAAMERYLNRTAAHPQLQKDPSFIEFLEKDELPKATSTSAMSGAAVKRAFSGIVDSAKKMTSKLHESDQWFEEKHQQIDNLDLQLKKLHISVESMVGHRRDLGGATAIFAKSAAMLGNSEEHTALSRALSQLAETEEKIDQIHVEQANTDFYVLSELLKDYIGLIGAVREAFREREKKFGLWQSAQATLAKKREQEAKLKVSGKPDKLAQCQEEIKDWEDKEAKGQKDFEKISKTIRKEYGRFEMNRVRDFRSVIIKYLEALMNHQQQVIQCWEGFLPEAKAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCN4</accession>
    <name>A0A8B7ZCN4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cystine/glutamate transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110986101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103433.1">
        <property type="nucleotide sequence ID" value="XM_022247741.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="B(0,+)-type amino acid transporter 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF375">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="259"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103433.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32186" checksum="FB09620B15E64700" modified="2022-01-19" version="1">MIQGNVKNLQDGFTPAIEVPPEKIPLAFYSGLFAYSGWQFLPSFTEEIVNPARNIPLGIIISMVIITGVYILANLAYFVVLSPTELLASEAVALTFGERVMGSWSVIISVAVAFSCIGSLNGALFSFARILMVSSREGLMPQVLGMIHVHNRTPLPAAIATFPIVIGMLMVPDINTLINYLSFTRWLFISIAVAVIPYFRWKYPDIPRPFKVPIILPIIFIICCLFVVGVSIYSSPVDCGIGAGITLTGIPVYLLFVWWEKKPSWFTNAVDAVTCFLQRYLLIAPEDKRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEV9</accession>
    <name>A0A8B7ZEV9_ACAPL</name>
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        <submittedName>
            <fullName evidence="12">Melatonin receptor type 1B-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110986175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103522.1">
        <property type="nucleotide sequence ID" value="XM_022247830.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110986175"/>
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    <dbReference type="OrthoDB" id="10042731at2759"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF74">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="88"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="165"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="47"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022103522.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37887" checksum="599F2B2D2ABC0D53" modified="2022-01-19" version="1">MDGNVGQLSFINGSIAPDSDPSEDDSLDGIVVIAMYLALLSVVGFIGNILVMVSVAISPKLRTTSYAFIVNLSAADLLINAIVTPLVVVSFFNSGWPHDLFWCRSLCYLLLLSVGVSLQTVMEIAASRYCFVSRPRQTYRKYFRWRVVAVLLAHNWLAPLLFIFIHRWSGFSGIQYHPVLRFCFLKYSGNPEFWYINGIMLYFLATCFLLIPCLYCMACRTLYASRRRVRPTLSKQNPGSSDHRPILRSAEVKFTKMMALIFILLMICWAPICIMHFFAVDALSHRLGIVLLLTNSSVNPFVYAWLNTHFKRAYKRILLCGKDQRGRVKPLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFF4</accession>
    <name>A0A8B7ZFF4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cullin-associated NEDD8-dissociated protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110986204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CAND family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103590.1">
        <property type="nucleotide sequence ID" value="XM_022247898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFF4"/>
    <dbReference type="GeneID" id="110986204"/>
    <dbReference type="KEGG" id="aplc:110986204"/>
    <dbReference type="CTD" id="55832"/>
    <dbReference type="OMA" id="AYIPHFQ"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000047">
        <property type="entry name" value="Cullin-associated NEDD8-dissociated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Stalled ribosome sensor GCN1-like HEAT repeats region" evidence="9">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022103590.1"/>
        </source>
    </evidence>
    <sequence length="1234" mass="137683" checksum="48953B48D5D0BBD5" modified="2022-01-19" version="1">MASVSYHISNLLEKMTSSDKDFRFMATNDLMSELQKDSIKLDDDSERKVVRMLLKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDNLCNNMLSEKEQLRDISSIGLKTVINELPPASSPLAANICKSITGRLTNAIAKQEDVSVKLEALDILGDLLIRFGGLLMSFHSAIQSALLPQLNSPRMAVRKRAILALGHLVMSSSNKLFADLMEFLMNELRENQNPSTTRTYIQCIGAISRHAGHRVGEHLEKIMPLVVKFCRVDDDDELREYCIQAFESFVRRCPKEVSQHVSTIIELCLQYICYDPNYNYESDEDEDAMDADAEEEEEGESDDEYSDDDDMSWKVRRSAAKCLEAIVGSRHEMLNEFYRAVSPALISRFKEREENVKSDIFHAFITLLKQTKPIVTGFYDPDSMEHEEGPISMLRLQVPDIVRALHKQMREKSIKTRQGCFSLLTELISVSPGALAEHIPAVIPGIQFSLGDKNSSSNMKIDTLSFLNCLMVNHNPQVFHPHMAVIVPPVVSAVGDSFYKITSEALLVTQTIVKVIKPLNSEATFDYGPYVLDLYSCTLMRLKAADIDQEVKERAISCMGQVLCNLGDHLQSELSTCLPIFLDRLKNEITRLTTVKALTMIAGSPLKIDITPILVKGVPILASFLRKNHRALKLSTLTALDMLLQNYGSALTMPMVDGILAELPPLISDSDLHISQLTLHLLTSVCRVHPTNAAKTRDAILPAILSLIKSPLLQGGALHAMLEFFQSLVATNTPGLGFQGLLQMLSLPIYSPPDTQSPSYAVHKQAFHSIAKCVAALTISCASEGSIVVNQFVNDVKNPKSSDSVQLFALLSLGEIGRHVDLSGHPELQKVIVDSFSAPSEEVKTAASFALGNVSVGNLPQYLPFVLDEIENQPKRQYLLLHSLKESITPTAVDHLKPFVGSIWTMLFKHCECSEEGTRNVVAECLGKLTLIDPQTLLPQLKECLSSESAFTRSTVVTAVKFTISDQSQPIDPLLKSCIQDFLRTMEDPDLNVRRVSLVTFNSAAHNKPSLIRDLLDQILPNLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHLEDGLKDHYDVKMLTYLMLVRLSTLCPPAILQRLDRLIEPLRNTCTTKVKANSVKQEFEKQDELKRSAMRAVASLLSIPDSDKNPQLTEFVAQIRCNPEMCSMFDSIQKDSSLTSADSLMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJ51</accession>
    <name>A0A8B7ZJ51_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Mucosa-associated lymphoid tissue lymphoma translocation protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC110987323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105663.1">
        <property type="nucleotide sequence ID" value="XM_022249971.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105664.1">
        <property type="nucleotide sequence ID" value="XM_022249972.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105665.1">
        <property type="nucleotide sequence ID" value="XM_022249973.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105666.1">
        <property type="nucleotide sequence ID" value="XM_022249974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJ51"/>
    <dbReference type="GeneID" id="110987323"/>
    <dbReference type="KEGG" id="aplc:110987323"/>
    <dbReference type="CTD" id="10892"/>
    <dbReference type="OrthoDB" id="412369at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052039">
        <property type="entry name" value="Caspase-related_regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041077">
        <property type="entry name" value="MALT1_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033540">
        <property type="entry name" value="MALT1_IG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576">
        <property type="entry name" value="MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1/PARACASPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22576:SF37">
        <property type="entry name" value="MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18703">
        <property type="entry name" value="MALT1_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="104"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="230"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="331"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="1">
        <location>
            <begin position="432"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022105663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022105664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105666.1"/>
        </source>
    </evidence>
    <sequence length="820" mass="93022" checksum="1BF8CA447C3AB875" modified="2022-01-19" version="1">MLTSTMDPNKLISDIPFSVLLKLSEYLDVGSNKMNWRALIANIPDQIYDDTQIEMFALAIHEYYGSPSLNLLRNLGSRGRTVRQLISYLDKMSHEKCLSLLKKPEKLRLLQIPCSQSVQAGPHSLVVLACNAKGFPYPQYCWYRAFAQTSGDQKEVKLEELENETDRVLRISPVREKHSGAYCCKVYHTINGAISQVFTDWAYLEVYPASYDNERDFLDSDEDLEHIAKPEIIQQPPVSLSVRPGKPIKVTCMATGCPTPKYQWYRYGYSSRDGPLEPHALRDQTDKTLYWAQSTTGDQGKYCCRVWNKAGCITSITVSINVDARLAESYPDKIEVVRHPQSISCRIGEPQILACHAAVSQGNLYYQWYHNHQEIPNAKQPEFHFLQVKPEDHGVYQCRVYNEYACVFSNEAMLNISGGLAPPTSNCRFYATDKVALLIGNMDYRSAEQLKAPEGDVENLTKVLSELDFKVVSLLDLNLQEMRFALSAFCDLLNSGVYGLFYFSGHGFESDGQSYLVPVDAGVGYSTKECICDQEVLDLMQYRNTALNTLLLDICRKPNDYPQKDPPEKFRPKVRGNTVFGYAAQTNTQAWEVDGQSSGIFTKYLIKRIRQAKKVSHVLEDVMEDVRNDCSANGIQYPAICHDLNEARSLCDPINPCGHTQEINARSRMWGEAHLLPESPMWVEFAHDIVVCVDLTTRFSNVMLMHTYIPPSCMGESTSCYVKLENFSPELDIKMDKQDVCFEYPSQAVIKMIITTVRNLQRLRGDLECTVTVEGEYRGKPFKQSRPLVISKPLVSNLWQTKHYAVPSEATYPDMTASTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJW0</accession>
    <name>A0A8B7ZJW0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reactive oxygen species modulator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein MGR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987403</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105809.1">
        <property type="nucleotide sequence ID" value="XM_022250117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJW0"/>
    <dbReference type="GeneID" id="110987403"/>
    <dbReference type="KEGG" id="aplc:110987403"/>
    <dbReference type="CTD" id="140823"/>
    <dbReference type="OMA" id="SCWDRVK"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105809.1"/>
        </source>
    </evidence>
    <sequence length="77" mass="7985" checksum="147851C0EA3A989B" modified="2022-01-19" version="1">MPVSMTPTGGPSCFDRVKMGFMIGFCVGMGSGALFGGFSALRYGLRGRELMTTVGKTMIQGGGTFGLFMSVGTGIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJY6</accession>
    <name>A0A8B7ZJY6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Uncharacterized protein LOC110987487 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC110987487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105938.1">
        <property type="nucleotide sequence ID" value="XM_022250246.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105939.1">
        <property type="nucleotide sequence ID" value="XM_022250247.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105940.1">
        <property type="nucleotide sequence ID" value="XM_022250248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJY6"/>
    <dbReference type="GeneID" id="110987487"/>
    <dbReference type="KEGG" id="aplc:110987487"/>
    <dbReference type="OrthoDB" id="535509at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016729">
        <property type="entry name" value="FADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15077">
        <property type="entry name" value="FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="86"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="175"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="316"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="406"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="643"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022105938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105940.1"/>
        </source>
    </evidence>
    <sequence length="1118" mass="125207" checksum="B69B487CBDD8D36A" modified="2022-01-19" version="1">MPLKTIRQLDEVIKTTTVVYDHSNAKLVSKKNKVRRCGKDAFLSSHPYSTFSCHRSAENKLLASSTTQPKFKHTNRRATKSTKQKLQFCVQAHLPLVPKTLSFELDPETPISTLKGLISKKFGVKPRHQRLYIRRDIWLCDLLTLHDNGIDKDDIISLSTHDAAQNGSKENTTVDEEYVCLLSSKIGSSWRKLAKHLGYEDAEIAEIQANIRVTSEASRQMLLTWRKKIRDRDEAFQKLRQALTTVGLTDLAQNVPDSCQSRDKVAGSQSEQHKDTKAAEQNKPKGATTSEAQTQLKGKDLKTDGPQALQYVKQKLQIFIGNPLLRGPRTFCFQLDPEASISSLKKLIHRKIGVLPQHQCLYIIRNCRNFQLCDLLTLSDCGIQQDENVLFRLSTDGLRGGGPKGDDQLLRDLSSKVQEFWIELAKILGIEESEIKNFQDLIESDKERSHQMLLSWWSRQGNREAGLEKLRESLISIGLFEQALLIPETCQDESLKTPSPISNEGESLKQDQAGNRQDAISQTKMQPKQAGEDDSLTAVGSDDLKDDGGNVSGSNFGTQSLGDAGDGTGPSAGLITGASGVVSRSVIDSKSDGDAGDTGVATAQLVGQITQAPGDALRGEVSTQPSYTSTKLSTSAIPAFKLSEQIMLELAEELGPQWEKLAIQLGFTSGVIEGFKSDNQTTVVMQGYKMLVAWMQKQDDDTEQQIKRLCAALTKAGRVDLTKTLQVFPGMQIETDLLKNGMKSRTMTLLFRELVKDLLSTCGESYVMHEFFAALKLWDLELEDVTYKSVVFVIRIKTRVGLEKLWAMYTTGELAKKLTEIFVTDDLTTEDKSDLSIQVTIPEKDYEQCCRFFEELDNATHEGNEQDASCKTTMQPKQFREDNSITTAGSDGHTEQATGRSAEKTNASHRTADNRQIDDQFLTDSSSNEVQKYRKECTDYRENEETAIKRFQTLSQGNKERSSQIPTLQCGKQTNRKEGIQKRREPLESNGLTEQAPDNAQTDDQFLPDLSYSEAHECRKQFTEYKGYEEPETKQFQTLSEKNKEHCFRTLIWWWKKHVEGLQGLIKALESIGIPGQAFLTLGHEQDINSGTEEQPKLLGQTSTEATAYNYDRAELCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKC3</accession>
    <name>A0A8B7ZKC3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GLE1 RNA export mediator</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC110987561</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106072.1">
        <property type="nucleotide sequence ID" value="XM_022250380.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106073.1">
        <property type="nucleotide sequence ID" value="XM_022250381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKC3"/>
    <dbReference type="GeneID" id="110987561"/>
    <dbReference type="KEGG" id="aplc:110987561"/>
    <dbReference type="CTD" id="2733"/>
    <dbReference type="OMA" id="AYMYKES"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.510:FF:000001">
        <property type="entry name" value="Nucleoporin GLE1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022106072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022106073.1"/>
        </source>
    </evidence>
    <sequence length="697" mass="79396" checksum="9B2BB56F22D90FDA" modified="2022-01-19" version="1">MSTLQALQLSRKGGHVYDSGWYKDGRVYETLVNCMSSPKISSEIAPPVLQNCSSTLKENDEQHPPDISEGSYIGIEDCGNVEEEGSFSNNASSSTLLYSTRDIKLDDIQATLALVKTGILEILIHECEQQWDKLPKERANERRLKLEELCRHLHDQASKSSSMLAEQLDEKTRMSLQSVQCTLRDKEEMRLQRVQHQQDRYKLHVKRMEVKLKTAIQKKVEAEEEAEHKRRVAERQAYLDSMMNVHKQIKESSKKICLQLEKDKQKDFLHPDAVKIKENVDQLSQQADRLLADAKLKGASMDLVENMHKIIESLMIHQERASRIIAEADRLSQEDAARKVREAQQQAAAAVAITHTPKSELSPLAQTSLKTSQNSVLQKAISADALEEYEGIRNKHKAVMDSYGKLAQTSDPQLKKYRFDLQKAVNVPVNAISNQCGSHLMDKLQRLRSLLLGEMVNVSGRRVSASQNTEGQPFVKDLLAKKIVKQSDEQVSSNYESAFPFAAIAVTLWCEFPDVGELMLAHFYLKCPFLVPYHITKSQDQSNEDYYKSLGYNYESDGVVEKQDKYLRRMSGFMRLYAAIMITQPMPGTKKVHPYGIDHAWKWLARLLNVEPQPDITATMLFDFLEVCGNALTAAYSRQFFKLIRVLYKNYFPKIVAVTPKGSGGPVVRLQTFLERVIKEQQIQPPKGKLQADFWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLB0</accession>
    <name>A0A8B7ZLB0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinase suppressor of Ras 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110987422</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105837.1">
        <property type="nucleotide sequence ID" value="XM_022250145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLB0"/>
    <dbReference type="GeneID" id="110987422"/>
    <dbReference type="KEGG" id="aplc:110987422"/>
    <dbReference type="OrthoDB" id="774951at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20812">
        <property type="entry name" value="C1_KSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF253">
        <property type="entry name" value="KINASE SUPPRESSOR OF RAS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
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    </dbReference>
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        <property type="entry name" value="ZF_DAG_PE_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="379"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105837.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="74780" checksum="BD5E6558D2038CEF" modified="2022-01-19" version="1">MLPEDRLTLQITDITTIMDILTRNTKNIIVRAKHCYSRKIVTNKRCDYCNKSMFLFALRCKDCRFKCHRKCAQNASPRCVLNLPGHKFRASSKPRQQSRPKNRAVQLARQAEPPYERLIYTPSFTPSRHREGLSLLKQCQCPTSCGLDATDIRRASDCDACKRLQASPPDSPKYTIGVRTRYSLLPPYQDFPGKPDMKQDCGTARQQLEDLSDPSKTDYHGDPVISTPKRPLIKTQWVQEGTWSNVSSMSCGYYSSNSECSSEVFQAQEEDSACLCSSGYGQTTVELSRTERHRKWSRGERSKTVDATVTRKRDTDMGKSLIATWPPHGHSNIKAGASPESLDDAHRMCDSLAASKHVGVVDHDIREAVKEWWIPNSDLKYGMCLRAGRNGSTYRGNWHGEVLIHTRRHVEDVDAFLEEVSVLSMIRHENIALFMGACIDPPNLAIVTCVQKGPSLFQHLHIKQSKSPMHSRIHIARQIAQGMGYLHARGIVVGDLNTKAIFLESKVKLCLTGYDTTDGMCDREDYATVPQGHLTYIAPEILRTMRVQPPYVIEAEPHTIESDVYAFGTVLYELLTSQWPFASTFACTDSVIYRVCNGKRASLAGVKCVPSVKSLVEDCWSHEPTLRPTFQEIVEELNQNAALVNMKHSLSEPDLLNRVGRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQ05</accession>
    <name>A0A8B7ZQ05_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Mitogen-activated protein kinase-binding protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8" type="primary">LOC110988366</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107478.1">
        <property type="nucleotide sequence ID" value="XM_022251786.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107479.1">
        <property type="nucleotide sequence ID" value="XM_022251787.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107480.1">
        <property type="nucleotide sequence ID" value="XM_022251788.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107481.1">
        <property type="nucleotide sequence ID" value="XM_022251789.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988366"/>
    <dbReference type="KEGG" id="aplc:110988366"/>
    <dbReference type="OrthoDB" id="6154712at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055292">
        <property type="entry name" value="MABP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056162">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44813:SF1">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24782">
        <property type="entry name" value="WD40_MABP1-WDR62_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MABP1/WDR62 second WD40" evidence="3">
        <location>
            <begin position="389"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="689"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="938"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1244"/>
            <end position="1334"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1351"/>
            <end position="1869"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
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        <location>
            <begin position="798"/>
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        <location>
            <begin position="989"/>
            <end position="1001"/>
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        <location>
            <begin position="1007"/>
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            <begin position="1302"/>
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        <location>
            <begin position="1553"/>
            <end position="1565"/>
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            <begin position="1576"/>
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        </location>
    </feature>
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        <location>
            <begin position="1605"/>
            <end position="1615"/>
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    </feature>
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        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF24782"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022107481.1"/>
        </source>
    </evidence>
    <sequence length="1869" mass="205612" checksum="D3EAC2520161C9C7" modified="2022-01-19" version="1">MSGNVSQRPNILHLAERTSMPVKKPVRAPMPKKRSKGVPLSERVTLERVLGLTVRDNRTFACNPITGLVVYPAGCVIVLFNPRRNKQSHIFSHSRKTITALAISGDGKNVVSGEYGHKPAVRVWDVEERTQLAELHGHKFGINCVAFSPNLKYVVSVGEEHDMVVNVWNWKDGSKLAAGKISVKVAGLSFSEDGSRFVTAGNRSIRFWYMSSKSKTRETFPLNSRAGLLGEQRNNNFCSVACGLGANQAKTYAVTKSGLLCEFSEQRLLDKWVELRTTSAYCIIASEGYLFVGCADGIVRLFNASTLNFVATLPRPHSLGVNVSDGIDPSHMITHRENARYPAAIAITHDDVSKKTTCVYNDHSMYVWDVHDVKKIGKQRSFLYHSSCIWGAEMYPSPTAGNKEALPPGSFLTFSSDDTIRIWNVDPAMTTDTFRRNIYSNELLKVIYADDQLEHLCSTDSDKADSLEGKNGIRCASVSADGQFLASGDRSGNVRIHDMQFMDEVHKIEAHDSEVLCLEFSRPESGCYLLASASRDRLIHVFNMQEDCSLLQTLDDHSSSITAVKFTQCNDRLQMISCGADKALMFRVATQNPEFEFIRNHHVVGKTTIYDLTVDPTEKFVATACQDRNIRIHNAVSGKLKRTYKGSVGEDGTLIKVELDPSGMYIATSCSDKSVAIFDFYSGECVATMDGHSELVTGIKFTSDCKHLISTSGDGCIFVWRLPWGFTHNMKERLNEMGQHMKQTPAYSMLRRGTYIVPPDELDPKAIAIETRSRNSTATPAVTESDSIAADTEMMDERGDEDNGDEEQDEVDWQGGPKLHSTADLPLWAKKQVCGEDLPSPTTYSNPAQPRGRWAQRLDSKGFKVKSEWDAHRDIELRLADGIDRRRYTVEPENLAEQVRHFAILHSAAIAEKERLQSSLHITEAEDFVPAEEGLADLEDQRDPSNPLLQGFVTSSRGSEPFLPPAGHTHSILSPDTPDEELNLGKAEEEQDEEEEEEEANEVIIYPPSEESSSSPESLKFQVTESTSSLEELQRRRARSVKKESPRSSRIIQDQGLTQVEESESTDPVSLGTSEDEDEDDAEDEVADEDNEAGNKEKPATEINPSSPTDPSPQGTSTTTASVTAATPAEEGARGQEAPGADREEEEEEEAGEDQESFLHTNYSFTEQEKFGKCLEQLQSGFASAGLSNGNHHRLSISSKFLSRSQLSHIRGVAASTRPTPSSSVGGVTAQVYLQRRKDTMAKAVDETRRRLQSMGWNSLRGKSTSSSSSTSSVSSATTTPISTLTSLNDCTPTATAASASTHEESCKREQTNCSEKPSESVVTWADSPSVRGGVAEDIEKSQENQKVLEDRMREIETEPTAESSPVVKQPENDSAVTKDSGSTPKEDVLRESQDVQETRDPETVKQRILGPTDKSGANSSEVQAETPTPDVRDGIFRSESPREVPAETSNSHPDSHSEGVVKSDDQSHIAIATSDHAHVPIIKGKRPASAPMETREAVEKANKENLDRSTKYDTYPGRRSISSSSQKKVDKMKARKEPTPSSTLRKTTSMSDLHDANLDQETRSESPSFNMVLRSHPRSHSMERKRLRANSPAREKHRARPDRVLPLVPGLPKPKSYEVGTASSLAKVSARKDETPPPSPSRTGRGKRASFGAAGEESRQSKSGGSSPESPPETTKNSASAEKQSAKDSLAEKNKQHADTDVTSQVTVTTDHAVDSKDAHKSSPPPTVSSQKEVELSAGKEQADKLAMPPPSSAAVAKSNRSFRRSSATRVELRQQRRRDPLQRPRQSQMVLPQLRTRRAPAIPSRPLRPLRRTPGPRLLGAGHPPTGRTAAAAYGRACRQKQPGKLPRQPSKPIPKRNLKQIPVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQ13</accession>
    <name>A0A8B7ZQ13_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonine synthase-like 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106990.1">
        <property type="nucleotide sequence ID" value="XM_022251298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQ13"/>
    <dbReference type="GeneID" id="110988068"/>
    <dbReference type="KEGG" id="aplc:110988068"/>
    <dbReference type="CTD" id="55258"/>
    <dbReference type="OMA" id="NFERYLY"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046360">
        <property type="term" value="P:2-oxobutyrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009071">
        <property type="term" value="P:serine family amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000047">
        <property type="entry name" value="Threonine synthase like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="103"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022106990.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="53626" checksum="15949A489852E346" modified="2022-01-19" version="1">MMKFITTRCQDKEYTFEEALFSPGYVAGGLLLPKTIPQISQEVLKSWLGLSLPQVCKQILPLFISGEEISQEDLEALIDDAYSRLPLDQVAALSSFPNGLNVLELGNTKTLAFKDLSTFIMARLLEFYFKKREKHVTILVGTSGDTGPSSIEAIRGSGWMDIVVLFPKGYCTEIQEIQMTTVMDENVHVYSVEGCSDDVDEPIKAVCLDQDFKAIHNLCTMNSINMCRVLCQIVAYFYGYLKVCRSVGDEVEIVVPTGAAGNITGGCLAYRMGLPIKLVCTVNSNDLLHRMLSTGELSTAPSVIKTYSVAMDIQNPYNIERIFSLFSNRDTALVKKIMEEFETGGKTTLPASLLQKMQKVLSSASFDNQTVLKTMQRCWSDHHYLICPHTAVAVSYYFSKLDRMEANQTLHQPTLCFASAHPAKFPEALVAAGLEPKPTPYITNLQVMPKRCLEMKRGQNWEKILREKIKEISKRAGVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQJ9</accession>
    <name>A0A8B7ZQJ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 41B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110987350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM41 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105706.1">
        <property type="nucleotide sequence ID" value="XM_022250014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQJ9"/>
    <dbReference type="GeneID" id="110987350"/>
    <dbReference type="KEGG" id="aplc:110987350"/>
    <dbReference type="CTD" id="440026"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF18">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="128"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022105706.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32548" checksum="B243E9396514B2A5" modified="2022-01-19" version="1">MSLRSQYKRPPLRESQENNSAKVNNMDKVDVINTTSELSEDDTTDRNKTTRSFIILGVIFLLALGVMGFVYVSFPRLDPDEVQYVKLPRDIEDAKALGRVLSHYSKTNYITVMVAFFTTYIFLQTFAIPGSIFLSILSGFLFPFPLALLMVCLCSAIGASNCYLLSYLVGVRLVMKYIPDKVESWSATVARQRHHLLNYIIFLRITPFLPNWFINITSPVLKVPITPFFIGTFLGVAPPSFVAIQAGTTLYQLSHYGDAVSWTSVIVLAVLAVVSILPVILKNRLGKKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZT27</accession>
    <name>A0A8B7ZT27_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Zinc/cadmium resistance protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110988595</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107980.1">
        <property type="nucleotide sequence ID" value="XM_022252288.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107981.1">
        <property type="nucleotide sequence ID" value="XM_022252289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZT27"/>
    <dbReference type="GeneID" id="110988595"/>
    <dbReference type="KEGG" id="aplc:110988595"/>
    <dbReference type="OMA" id="CFTIFVD"/>
    <dbReference type="OrthoDB" id="29444at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="13"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022107981.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="40053" checksum="EFE8761F62519991" modified="2022-01-19" version="1">MGRFTGKSCRFVVMMSLTTSFFLVELVTGYATKSLALVSDSFHMLSDIIALVIGFLALRISKRRSTKGCKRAEVLGALINSVLLIALCFTIFVDAIQRLIVVETIHNPMLVLIVGCVGLAVNGIGLCLFGRHGMPHGHTQTRAPDSKWKKLNVKESSDEEMERVLGPSDPTTHDSTDTDTLAVNGTHSVQMAEDQDDETKNKATVTAPSHAHLNMRGVFLHVLGDALGSVVVIVSALFIWLTEFEWRHYVDPAMSLIIVAIITVTTIPLFRQSSKILLQSLPSEINENSKDAENPPENKTGNSYVATAHILFHDKADYTVMADDIKSYLVDKRIDARTTLQDPAIVCSPSDSMKSSPCESSHERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUM8</accession>
    <name>A0A8B7ZUM8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dynein assembly factor 3, axonemal-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110988204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Dynein axonemal particle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNAAF3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107211.1">
        <property type="nucleotide sequence ID" value="XM_022251519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUM8"/>
    <dbReference type="GeneID" id="110988204"/>
    <dbReference type="KEGG" id="aplc:110988204"/>
    <dbReference type="CTD" id="352909"/>
    <dbReference type="OMA" id="MREGIYQ"/>
    <dbReference type="OrthoDB" id="538817at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120293">
        <property type="term" value="C:dynein axonemal particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070286">
        <property type="term" value="P:axonemal dynein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039304">
        <property type="entry name" value="DNAAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028235">
        <property type="entry name" value="DNAAF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118">
        <property type="entry name" value="DYNEIN ASSEMBLY FACTOR 3, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22118:SF14">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14740">
        <property type="entry name" value="DUF4471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="6">
        <location>
            <begin position="10"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein assembly factor 3 C-terminal" evidence="7">
        <location>
            <begin position="139"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022107211.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="55127" checksum="2E37D781533807EB" modified="2022-01-19" version="1">MVDAFGAITWWGFSPALDFQDKVRDSESSSDLNILMIGAGDCRHMLKTLALSHRHTKRKINFYVVESNLELLGRHLLLTSIALESPKLMGLQEKTELFLEVFGNSLVRRQTRDYIVSKANDFIRMVTDLDYLARELPAFDLSLLKFKERDQLEAIFKFWRGSDDRVFDISKCWDNRLRHYLANRYDSRVGVYDWDYNMKLLDRGAGIIHKKEYSYWRETGSAFSVREGTYDVPNKTLASGLIVKTSGGNVPQRGYWGDIVSSPYLAFGIECNEASLMKKTNDTYTKTAQDISEYNILAILHELTTGEKYVLPKPSKETESKEKANSEGAKLEEITEEDEEEEEEEKSNKNEEKELEENGESDQTSVEHENIPIEDVKIHFLPIGSAREINKKGKYKGLFNIIYLSNSMVHYLTEDLRAVFADQAMVITETARFMLELKTEQCQEFLSKVTGMATAVGCQITSHGDALKDSFLRFRFERKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUQ0</accession>
    <name>A0A8B7ZUQ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110988222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110988222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107236.1">
        <property type="nucleotide sequence ID" value="XM_022251544.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988222"/>
    <dbReference type="KEGG" id="aplc:110988222"/>
    <dbReference type="OMA" id="ICESASW"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000023">
        <property type="entry name" value="Solute carrier family 22 member 6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="895"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="950"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="976"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1134"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1187"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1211"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1243"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1364"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1395"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1422"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1450"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1476"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="101"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022107236.1"/>
        </source>
    </evidence>
    <sequence length="1532" mass="170161" checksum="725F3742042C0DE2" modified="2022-01-19" version="1">MKLEEILPLLGNFGRYQFFMICYGGFLAMTTCIVTFGHVFYAAETDHWCSVLPDANCSSWPELQDNCTDVKKSIFLPPPESNDSKYPHSNCDQWDLPDGYAFDPYVPPTDVDNFTYSAVPCESGWMYDTSQYKTTINSDFDLVCDTENLPSLAQSIYFVGFLVGSLVCGSLSDWIGRKKALFVGLISYVIGSLVTTFSVNIYMYMGFRFLAGFGNIGTYITIYVLVLELIGKPYRTRGSLTLSVCFALGYFVLAPIAMHVHEWRTLCLIMASTTIPLFVPLIFVEESVVWLVSKGKFEKAEAAIRRVAKMNEKTLPDVLFEKDDFEEANTGSNDSTVPPSVIDLLKTPNMAVKTINMMYNWLVNSLVYYGLSQSTGDLGMNEYWAFFLSGAVEIPGKLYAMFGLDLFGRKWNLAVLELIGGVACLATIFIPIGVWRTVVSMLGKFCISVTFGTIYLYSSELFPTPVRTAGVGICSVSSRVGGIISPLILLLGSGPSSAVFGSSAILAGLLVFFLPETKGQKLPQTLEEGEEMGKCRCMKSGVDSESVVEMDGIDKYKDSAIALSNLAFDSKEENKSDFSQQYDAKSTRIDDLRTPQNMKLEEITALLGSFGRYQIFLIVYVYFVSNIGCYVTFGHGFFAAGTDHWCSVLPHENCSSWPVFQRNCTEVKRALFLPPSEDESSIYPYSNCKQWDLPDGYVFDPYTPLGDVDNFNYSAVPCKGEWMYDTSQYKTTIISELAQSGIRLPGPPHFLDTMLTYLSYCLFSFVKESISWLVSKGKLEEADAVIRRMAKFNKKTLPDVLFDKEDDQNEMESRESAIPPSFIDLYRTPNMAVKTINMQYNWLVNSLVYYGLSQSTGDLGVDDYWAFFVSGAVEIPALGYAAFGAERFGRKWNTVVLELIGGVACLVAIFIPIGIWRTVVSMIGKFCISATFGIIYLYSSELFPTPVRAIGIGMCSVSSRIGGIISPLVLLLGRNVPSIVFGSSAIVAGILVFFLPETKGRKLPQTLEEAEAVGNHGFFAAETDHWCSVLQHENCSNWPEFQDNCTEVKKAMFLPPSENESSIYPYSNCEQWDLPDGYVFDPYLPLGDAENLTYSAVLCKSGWVYDTSQYKTTINSEFDLVCEDKDLPSFSQSIFFVGVLVSSIIAGTLSDWFGRKKALSVSMLLWAASFIVTSFSVNVYMYMAFRFLSGFGSYGAWLSAYVLVIENVPKSWRTAVTVLFDIAFAVGYLFLATAAMHVREWRPLCLIMSLVTIPLLFPLPFVQESIGWLVSKGKLEEADVVVRRVAKFNKKTLPDVLFDKEDTREEMVEMQEFKESGLPPSLIDLYRTPNMAAKTINMQFNWLVNSLVYYGLSQSTGDLGVDDYWAFFVSGAVEIPALMYAAFGVERFGRKWNTVVLELIGGVACLIAIFIPIGIWRTVVSMMGKFCISATFSIIYLYSSELFPTPIRAIGIGMCSVSSRIGGIISPLVLLLGRNVPSIVFGSSAIVAGILVFFLPETKGRKLPQTLEEAEAVGNLRKSCPFWGTSAATSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWE2</accession>
    <name>A0A8B7ZWE2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">LOC110989200</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022109080.1">
        <property type="nucleotide sequence ID" value="XM_022253388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWE2"/>
    <dbReference type="GeneID" id="110989200"/>
    <dbReference type="KEGG" id="aplc:110989200"/>
    <dbReference type="OMA" id="DYTEYIA"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="CD80_C2-set"/>
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            <end position="727"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="24">
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            <begin position="374"/>
            <end position="385"/>
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            <begin position="457"/>
            <end position="464"/>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWI9</accession>
    <name>A0A8B7ZWI9_ACAPL</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
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            <taxon>Acanthaster</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="component" value="Unplaced"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
            <begin position="28"/>
            <end position="52"/>
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            <begin position="43"/>
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        </location>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022109789.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36026" checksum="DFB972DB3CB23089" modified="2022-01-19" version="1">MDEHKDNLTHNSSGCLEEVCTSYSERQVFAAIFGIIFVVGTVGNALVIAAVILSRKLRNATNMLVLNLSIADFLTCVCVIPINAAAILSEDSWPLVNSSCKFAGFLLAVCTGCSLNNLACIAINRYVMITKSKSTYRTMFNRRRTLAGVILTWLVPLAVVICPALTGIVEIAFNLDASLCTWLSLYPEHLHAYPFNFIFFALSVPIQVSLIFLSYISILCHIRTHTKRVRPDSNLQIQVTKNLALVMCVFMLCYVPSCIKLLLSSPMPMWFRRASFAIFLANSCVNPLIYAAKHPNFRVVFCCIIRGKWKDIPERVSFQFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXT7</accession>
    <name>A0A8B7ZXT7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Short transient receptor potential channel 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC110988814</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108371.1">
        <property type="nucleotide sequence ID" value="XM_022252679.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108372.1">
        <property type="nucleotide sequence ID" value="XM_022252680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXT7"/>
    <dbReference type="GeneID" id="110988814"/>
    <dbReference type="KEGG" id="aplc:110988814"/>
    <dbReference type="OMA" id="CESNDIH"/>
    <dbReference type="OrthoDB" id="10037738at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070679">
        <property type="term" value="F:inositol 1,4,5 trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015279">
        <property type="term" value="F:store-operated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013555">
        <property type="entry name" value="TRP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002153">
        <property type="entry name" value="TRPC_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10117:SF54">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL-GAMMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08344">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01097">
        <property type="entry name" value="TRNSRECEPTRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01420">
        <property type="entry name" value="TRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Transient receptor ion channel" evidence="13">
        <location>
            <begin position="151"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="897"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="902"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="981"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022108371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022108372.1"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113119" checksum="DB330CA34EBD4912" modified="2022-01-19" version="1">MGDGISPEVARERYFIAAMKGDVKGMKDSLEKSLQHNLDINCTDASGRTALHVAIENGNLGVIYPLLDHGVQIKDAVLRAVEHDFSEAVRILCDRAHALKDATERQRIIDCHCANDDFHPDITPIILAAQRKNFPMVKILLENGVRIPQSHDFQTAAKDSFQRSVGTMEIYKGLASEAYVAMASKDPVHRAFTLCDELRKLEEIEIEFKVGYNALQNDMENFATEFISQARSTEEIMTVLTHQDEDNVLIGDCASHSPLPKISSALDLGLQKFIAHPNCQQVIITQFYRRLLFLRDKKVVYRFLFFALLLLLYPVLAVIHVYSSHKKLKTFVRIPIVMFIMYLASDLTFVTLLTWEAVSDGGEAHNPSISRPYAIAAMVWITGLLWREIECVAARGFRKVMTQWEHIRDTLIILLFLVGVSLEMFSYFSLGPELVNGVPATPDYARSRRSVEVPPPAVARNFTEGKLADISNYVIGELERSHPDINETSKTHVKLVVARVLNYTARRRTGGKASFQEDVVNKGPTTPIDGEHSIFVRRPWNHPQIMARALLALATAFTVLRMLPYVVISDLIGPLQISLVGMTIRTSHFFIVVGTVLGSFAVGLTLTYSYHNEKEYNHCTSTAENPEICKRGSFADIFQTLVTLYWSVFGLMPMTDLELPKNAVVMETAGSLLYASFYVLLIIVLLNALIAVWSNVYNDIEENADRQWKFSYTAMWMAFIQDDLRVPPPFNLLPTKSCLRRIISLFSKRGRWAEIATEEMNIMYDDKWLRTEGVRLFIDGSKKMSKQLGEQVNYSRVIALLLDRYVTEKTAGACSSTAEVSKIDLRNLKNDLIALRYDTFLRLCNVHDELVAASNECFHIQGKSNHVPAIFDRAEDISSNLIYNLHHTLDFQTSLADTVSRLPPPPPTPPPTPPPPQPPPQPPPQPPPPPAPSTAPAQVPSLDLEDPEEPRQRPLTPQMVRRGVRRIVVRLVKQFETGQIGPSSRGSPVRRSSLASDSSYRDTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0Q1</accession>
    <name>A0A8B8A0Q1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA repair-scaffolding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110990521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111259.1">
        <property type="nucleotide sequence ID" value="XM_022255567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0Q1"/>
    <dbReference type="GeneID" id="110990521"/>
    <dbReference type="KEGG" id="aplc:110990521"/>
    <dbReference type="OMA" id="KTCRCTF"/>
    <dbReference type="OrthoDB" id="1914453at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070202">
        <property type="term" value="P:regulation of establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053054">
        <property type="entry name" value="DNA_repair-scaffolding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028026">
        <property type="entry name" value="DUF4502"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028032">
        <property type="entry name" value="DUF4503"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34347:SF1">
        <property type="entry name" value="DNA REPAIR-SCAFFOLDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34347">
        <property type="entry name" value="DNA REPAIR-SCAFFOLDING PROTEIN SPIDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14950">
        <property type="entry name" value="DUF4502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14951">
        <property type="entry name" value="DUF4503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4502" evidence="2">
        <location>
            <begin position="14"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4503" evidence="3">
        <location>
            <begin position="502"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4503" evidence="3">
        <location>
            <begin position="714"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022111259.1"/>
        </source>
    </evidence>
    <sequence length="942" mass="103687" checksum="9303A9A1CA94B9E4" modified="2022-01-19" version="1">MLNKMRHVTAQPLSDQGWGRCQAEFQGVDWGTEERTRVKYQKRKRSKKMGLESVAVDEQGSLDIDWSSSSDNLSDAEPLPHQEASRSGPRKHLKRKKSYGSSRRRVNQGPMRFRGLLEGEDVDIMDEEEENLGGSVLGSWMMKSSSSSKNKDEASSSEDRKSTQIVISDYDSPSEEQGTAASSSQQASSSLHISDQSPTPQPSPCQSPDKESPRTGTELLKKLKLPARTPDKEAGVGGPSGGGDSTKKKRKFVRGGLAEGLQRVINREKSAMAFWAHRTVDTATSQSLMLDLLVLSVEEARGLYVTRCRMCPFTSEAPDDDDMLVLFAQANGRQLKLGVGSRIRVYPPWQKLTLPNYKETVILCTYFCHPVDTADETPPDVATTQSLFPNKTAGMSLEKELKPVRLFQPLPKQTTSADSTLQLVLPNVKEAPADHVSDSFLDSIAQSGGYTTAGMCVRARIHRVHCRGSNAEPVSMNRKQQGFSKPTHESSVGSTHWALILQDNHGVFCELQVTVGYTGEEEEIWRRSLRGGEGKTMVFAGLKVMRRVNRTRFPGLFSLIDSLWSPCDTPISQSEAESQSQGLVSPQSFCYILGVQMLRNTIREEVSDRVRIPYREPVIHTLREVQQLSDETSTQRVTFFAKVVHAHSEVGADNMQSTQQLGSSSVRHLFLTDHTLCSDFTADEEDESGTMTGMLGRSIPVGGAGFSAHQCQDTRLVYVHVRVSCHLTECVQESLANPGSLMLFRDVCLDQGCSLHADTYTAIQSIARKTGQCGESDTFSPKDDIISSLSHAPVPPIPTLDLHNEENTLVSVAGVVTGVDETTAYSWPACNTCGNNRLEAETTSGSQLHCGTCQKVVTSPVTRKHLELFLRCPSLKSEDSVVKVRLLQPSIEHILPPLNSQEEGYDLQCIMGVSIGPVSCFLRSVGRQPGEPLTFDLEEVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0X1</accession>
    <name>A0A8B8A0X1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110990629</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111403.1">
        <property type="nucleotide sequence ID" value="XM_022255711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0X1"/>
    <dbReference type="GeneID" id="110990629"/>
    <dbReference type="KEGG" id="aplc:110990629"/>
    <dbReference type="OMA" id="NIDWIPF"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="2">
        <location>
            <begin position="176"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111403.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="37219" checksum="41C9190C8E237794" modified="2022-01-19" version="1">MASRGVHLESANSLSASSFINVLRRFQSRRGPVRQLRSDQGTTFVGARSGLREVLAEMEQDRVHQYLLENNCDWIPFKQNTPHASHMGETNWHGAPNIRGSSSQYRNTIQLDDESFRTFMTEVEGIINSQPLTTDYLCSADAPEPLTPSHLLTMKPKVVLPPPGKFQKEDIYAHKWWRRVQYLTNEFWVRWRKEFLHQLQERKKWVHPERDLQVGDVVISKEGEQTRNQWPFGRVMETHPSNDRRVRSFFFQAEDGIRDNLGRRQYSPSLLDRPVHKLVLLVPATETQIETQETREVPTEEPKLETLPEKTTTDDKLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2W7</accession>
    <name>A0A8B8A2W7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990947</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111712.1">
        <property type="nucleotide sequence ID" value="XM_022256020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2W7"/>
    <dbReference type="GeneID" id="110990947"/>
    <dbReference type="KEGG" id="aplc:110990947"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111712.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22686" checksum="233A8C009C267483" modified="2022-01-19" version="1">MGASVSSFVTLRLHQGVLEWGGPAFMKSFAEDPFVIGRFKEAAIQRPSNLFGSNYHESRFPPPSSPPTCDTPANQLSAIALRRVITRACNPKHVKRFWTDELNKPSWWPGEIPFQSPNWVSGDQQRLNVFQLSAVYEAYTAHSRVSSDAAQGPSPSSQAGPPPDFSAGAGTSADASTTARQPDSPLTPPGTTAGTTSDQRKVLRDFQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A4B7</accession>
    <name>A0A8B8A4B7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC110990203</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022110764.1">
        <property type="nucleotide sequence ID" value="XM_022255072.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110765.1">
        <property type="nucleotide sequence ID" value="XM_022255073.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110766.1">
        <property type="nucleotide sequence ID" value="XM_022255074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A4B7"/>
    <dbReference type="GeneID" id="110990203"/>
    <dbReference type="KEGG" id="aplc:110990203"/>
    <dbReference type="OrthoDB" id="427096at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000004">
        <property type="entry name" value="Glycoprotein 3-alpha-L-fucosyltransferase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF145">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE FUT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="184"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="291"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022110764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022110765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022110766.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="57525" checksum="EBC6A444854E5A54" modified="2022-01-19" version="1">MAPLPPVPRRASQRPPVLSRALDVGSRHFKSSHQDQELLSLPNYSIPGNLKIRNPPMKRLHLLTILAIVLFGVDILIRLRVMERTIPTFTNHRRALPKHFFTNKRNTRSGSSVLPLAANDTVTKFDRMPDLKTKEPCSYNIQVYDRKGILLKERYETFSSIAPTLKGREKIPAVVQCGRNCTITITIADEKNKFAGMDAVLFHFCMRLVPLKALPVDMNPNQTWVFCSWETPYISTTPEVQRLYKIPKLKGFTANALWTYHRETEITTQFGFYTPRIPTVNETRTADEWLEGKTKLVLWVGSNCKITSWPRLTFVKKLQSYVPVDVYGRCGNLTCKPRTSKCNKDLVRNYKFYLALENSECDEYVSEKTWDKTLLVGVVPIVYGAPRKDYEEFLPPNSFIYVGDYNTVKELADYLKLLDSRPDLYAKYFEWQYKGHVRSTRVFYNTFPPTRFCHVIPIIEKVRRGELPRKPVLSSNFYQTCRKKPDFVLDQWNPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A6B8</accession>
    <name>A0A8B8A6B8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990737</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111526.1">
        <property type="nucleotide sequence ID" value="XM_022255834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A6B8"/>
    <dbReference type="GeneID" id="110990737"/>
    <dbReference type="KEGG" id="aplc:110990737"/>
    <dbReference type="OrthoDB" id="5970210at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111526.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24152" checksum="CCB44584CA2CB106" modified="2022-01-19" version="1">MLSRPLCCSLACPTLAIYINHSWVSFSGFSESYNGTFKLTRHTGLSAKNVSSAFFNGELENKMREHGHLDMFNMVKVDSDKDKVLAEIEKLRRKEPYEHRNCHANCKAKAISCHVHLTKKTTLKELMRHKKYGLVSSNQYTQKEILQLEAVGHGHGGDPEDRQQNCSESTLLLPGNCFDCHNSHRQHRLSAFFRNLQFSIEIITCIRRDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A854</accession>
    <name>A0A8B8A854_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Toll-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110991250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tollip family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112251.1">
        <property type="nucleotide sequence ID" value="XM_022256559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A854"/>
    <dbReference type="GeneID" id="110991250"/>
    <dbReference type="KEGG" id="aplc:110991250"/>
    <dbReference type="CTD" id="54472"/>
    <dbReference type="OMA" id="IYIQIFD"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="entry name" value="C2_Tollip"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Toll-interacting protein-like Protein"/>
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        <property type="entry name" value="Toll-interacting protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="CUE"/>
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    </dbReference>
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        <property type="entry name" value="Tollip_C2"/>
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    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
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    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="42"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="11">
        <location>
            <begin position="246"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009278"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022112251.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31824" checksum="156155BB5CC0C779" modified="2022-01-19" version="1">MATETTTRNPRQNVMVGDLPPDFLRIQGVSGGQTQNSLQISADEQTARALQYGQAGMQVAAGPYVGRLSITIVQAKLAKNYGMTRMDPYCRIRVGHAVFETPTDLNGSKNPRWNKTIQCNVQPGVDSVYLEIFDEKSFGADYRIAWNHIQIAPSVFQGEVKDDWYPLTGKQGDEKEGMINIVLSHQQVQQMPLFTPQVVYGAPQTMVIPGPYGYAPVAPNMMGYPPQAVPQQPQRQPSQAHQAPQITEADITSLKDMFPNMESEAIRSVLEANNGNKDAAINNLLAMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-10-11" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q68YC7</accession>
    <name>Q68YC7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 19">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="6 19">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">COI</name>
        <name evidence="25" type="synonym">COX1</name>
        <name evidence="25" type="ORF">KEG27_p11</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="22 25"/>
    <reference evidence="22" key="1">
        <citation type="submission" date="2003-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Yasuda N."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2004-08" db="EMBL/GenBank/DDBJ databases">
            <title>Acanthastar spinosa mitochondrial COI gene for cytochrome c.</title>
            <authorList>
                <person name="Hamaguti M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="23 25" key="3">
        <citation type="journal article" date="2006" name="BMC Genomics" volume="7" first="17" last="17">
            <title>Complete mitochondrial genome sequences for Crown-of-thorns starfish Acanthaster planci and Acanthaster brevispinus.</title>
            <authorList>
                <person name="Yasuda N."/>
                <person name="Hamaguchi M."/>
                <person name="Sasaki M."/>
                <person name="Nagai S."/>
                <person name="Saba M."/>
                <person name="Nadaoka K."/>
            </authorList>
            <dbReference type="PubMed" id="16438737"/>
            <dbReference type="DOI" id="10.1186/1471-2164-7-17"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="23 25">Tube foot</tissue>
        </source>
    </reference>
    <reference evidence="25" key="4">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="NCBI Genome Project"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="25">Tube foot</tissue>
        </source>
    </reference>
    <reference evidence="25" key="5">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="25">Tube foot</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 19">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Mitochondrion inner membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="6 19"/>
    <dbReference type="EMBL" id="AB116377">
        <property type="protein sequence ID" value="BAD36755.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AB231475">
        <property type="protein sequence ID" value="BAE79168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_492655.1">
        <property type="nucleotide sequence ID" value="NC_007788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q68YC7"/>
    <dbReference type="GeneID" id="3907688"/>
    <dbReference type="KEGG" id="aplc:3907688"/>
    <dbReference type="CTD" id="4512"/>
    <dbReference type="OMA" id="WAMMSIG"/>
    <dbReference type="OrthoDB" id="10002679at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01663">
        <property type="entry name" value="Cyt_c_Oxidase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.210.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="entry name" value="Cytochrome c oxidase-like, subunit I domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033944">
        <property type="entry name" value="Cyt_c_oxase_su1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422:SF18">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="Cytochrome c oxidase subunit I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 19" id="KW-0186">Copper</keyword>
    <keyword evidence="14 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0349">Heme</keyword>
    <keyword evidence="16 19" id="KW-0408">Iron</keyword>
    <keyword evidence="18 19 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 22 25" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="11 19 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome oxidase subunit I profile" evidence="21">
        <location>
            <begin position="1"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="BAD36755.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="BAE79168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="YP_492655.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="57043" checksum="2C5BAD7CE82EAA4D" modified="2005-09-27" version="2">MQLSRWFFSTNHKGIGTLYLIFGAWAGMVGTAMSVIIRTELAQPGSLLQDDQIYNVIVTAHALVMIFFMVMPIMIGGFSNWLIPLMIGAPDMAFPRMNNMSFWLVPPSFLLLLASAGVESGAGTGWTIYPPLSSGLAHAGGSVDLAIFSLHLAGASSILASINFITTVINMRTPGISFDRLPLFVWSVFVTAFLLLLSLPVLAGAITMLLTDRNVNTTFFDPAGGGDPILFQHLFWFFGHPEVYILILPGFGMISHVIAHYSGKSEPFGYLGMVYAIVSIGILGFLVWAHHMFTVGMDVDTRAYFTAATMIIAVPTGIKVFSWMATLQGSNLRWDTPLLWALGFVFLFTIGGLTGVILANSSIDVILHDTYYVVAHFHYVLSMGAVFAIFAGFTHWFPLFSGVGLHPLWGKIHFALMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTISSIGSTISLVATLIFLFIIWEAFTSQRTTVRPEFAPSSLEWQYSSFPPSHHTFDEIPATVYLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGD3</accession>
    <name>A0A8B7XGD3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Granulins-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Granulins-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110973371</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the granulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079842.1">
        <property type="nucleotide sequence ID" value="XM_022224150.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079843.1">
        <property type="nucleotide sequence ID" value="XM_022224151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGD3"/>
    <dbReference type="GeneID" id="110973371"/>
    <dbReference type="KEGG" id="aplc:110973371"/>
    <dbReference type="OrthoDB" id="5854875at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.160:FF:000001">
        <property type="entry name" value="Granulin precursor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.160">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000118">
        <property type="entry name" value="Granulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039036">
        <property type="entry name" value="Granulin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037277">
        <property type="entry name" value="Granulin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274">
        <property type="entry name" value="GRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12274:SF3">
        <property type="entry name" value="PROGRANULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00396">
        <property type="entry name" value="Granulin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00277">
        <property type="entry name" value="GRAN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57277">
        <property type="entry name" value="Granulin repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00799">
        <property type="entry name" value="GRANULINS"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665425" evidence="5">
        <location>
            <begin position="35"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Granulins" evidence="6">
        <location>
            <begin position="722"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022079842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022079843.1"/>
        </source>
    </evidence>
    <sequence length="744" mass="78464" checksum="C75FBEB5C412DC55" modified="2022-01-19" version="1">MKHWLDNRLSQVICRMRHALLAGILLTLAYAAFADEAVNVVCPGGQYQCPSGDTCCRLSSGQWGCCLYAHAVCCSDHIHCCPSGYTCNVANGTCNRGDLLMPLATKNVAQPVEAVNVVCPGGRYECRSGETCCKQGGGKYGCCPLPMAVCCNDSVHCCPKGYKCNVAHGTCTKGEFNLPWYEKNDAQEVELQSVVCPGGQYQCPDGNTCCKLSSGQWGCCPLPNAVCCSDGQHCCPHGYTCDVSSGSCHQGELVIPWEEKNLAKPVEILPEPNIVCPGGQAQCPSGNTCCRLASGQWGCCPLPSAVCCSDHIHCCPHGYTCDISTGTCSLGEMTLPWFEKTDANVVVPEPNVVCPGGQAQCPSGNTCCRLASGQWGCCPLPSAVCCSDHIHCCPHGYTCDISTGTCSLGEMTLPWFEKTEATFLSSDSVPVPNIVCPGGRYQCPTGSTCCKLNTGAYGCCPYPLAVCCADHIHCCPHGYSCDISTATCHLHDLSLPWEPKKEAALLSDPAVPEPNIVCPGGQAQCPSGNTCCRLASGQWGCCPLPLAVCCSDHIHCCPHGYTCDISTGTCSLGEMTLPWFEKTAAALPSNGGIICPNSSSICRSTETCCMMAKGGWGCCPGVNAVCCPDKIHCCPHGTKCTKENTCVGAAGILSMVTKTKAKEMAPKVETVPWITKTLALPLGTKEGNVKCDSSHFCPDGNTCCKLASRQWGCCPLPNAVCCSDGIHCCPHGYTCDTASGRCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHM4</accession>
    <name>A0A8B7XHM4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gastrin/cholecystokinin type B receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholecystokinin-2 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 22 23" type="primary">LOC110973240</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22 23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079611.1">
        <property type="nucleotide sequence ID" value="XM_022223919.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079612.1">
        <property type="nucleotide sequence ID" value="XM_022223920.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079613.1">
        <property type="nucleotide sequence ID" value="XM_022223921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHM4"/>
    <dbReference type="GeneID" id="110973240"/>
    <dbReference type="KEGG" id="aplc:110973240"/>
    <dbReference type="OMA" id="KAHAYKA"/>
    <dbReference type="OrthoDB" id="5987936at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015054">
        <property type="term" value="F:gastrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009126">
        <property type="entry name" value="Cholcskin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000314">
        <property type="entry name" value="Gastrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF75">
        <property type="entry name" value="CHOLECYSTOKININ-LIKE RECEPTOR AT 17D1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01822">
        <property type="entry name" value="CCYSTOKININR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00527">
        <property type="entry name" value="GASTRINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="73"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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    <sequence length="425" mass="47610" checksum="98800CF184DDBE91" modified="2022-01-19" version="1">MATTVSTPGTILPTEFSSVVVVTEEDAYTNGTDSWLGETIDIKQNDSVRIGFALQEEVVYTLYAIVFVLTVVGNILVIVTLVQDRRMRTVTNMFLLSLSTSDLIFGIFCMPFTVVGNVLGRFVFGEVICKMLPYIQGTSVTVSVWTMVVISLERYHAICHPLSSRIWQTKAHAYKAIAGVWLVAVLLNLPALIFTTLKSINSETAYKCYEHWPEGPYVQIYRLCLFVILMVVPLFLMAISYGLIIVELQKGMKLEKSTADNEKGENGIRMKNLDEASCSLNERVTKKATTSTAVRSTSTSDAKKRVVKMLIIIVALFFICWTPSWVTNIWITVNLESAKKHFGRPEVTIFKLMTYTSACVNPVVYCFMNKRFRQGFLNAFACVRIRASERATASENVSRFQSGRRANLTRPSPTNYTNVSSDSSV</sequence>
</entry>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <sequence length="341" mass="38684" checksum="BAE901F833CBCA8D" modified="2022-01-19" version="1">MSFSNVTNNTDFEDVDQSVIDAIGIVTAILTVVGFFGNSGIILIVLSNRSMRNRPNALVASLAVGDLLVVLVSAPLRIYQMVYYMWPFGLLVCKFSHTFSIISQAVSIFSMVALSHDRYRAIVTPMNYSRFRGSGHTVAIISVVWFLGFIFSIPALIFSEVIRNEHFTYCIVIHDMSTEGKVYTVMRGLVLFIMPLMIINVYYCMISRKLIASTRALPGEVHDKRSQISSRKRLAYLVLAIIVLFIVCWFPFFIFQIIFHVDSSILFTPIMTYLRLLAEALTYANSCINPILITVVSSTYRKYFCSYLRCRCFRKAKFIRPRASTVSSKASSARTRITEFA</sequence>
</entry>
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    <accession>A0A8B7XIU7</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973860 isoform X1</fullName>
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        </source>
    </evidence>
    <sequence length="2818" mass="304714" checksum="0D5F3479466EC8B7" modified="2022-01-19" version="1">MSATVEINALSTGSGSGKYEVNSNVVSDLSAAGDCSAGTPGKYRPLRVQQPACTAAGDPLCSEQESLKITDKNANQDAASDQKSDIQSKDQEQPSLSGDSEFKSRNLEGERGNLIENGNNIDLGDGSKSSAEDLELDSCVCQDANNLEKSYISSKSDHRDGGDFDSEDKAPKAFEDSVATEANKQDHSMYNNSSSPQEEEQEEVGAVKQKSKKKGGLLHLHLPKFGMKRGHGAKGGEGSTSSDPESSPEKHSKKTRKRDKHRKQEEDEDGDAAKVHVANEEDAAVEESCQIPDFEQDKHDKGDFDKDPKEMQGSGHDENIDVAIVTENTVARVVASPAEKQPDQMDMRPEEDAAGQHTGHTADPEPKEEIFNTEDAVAKVTGKDRDEEGAKCGDAAKITSGPTDNEPSSIPSSSLASGDDFYTLPQSSLGSSTDPCNSEISDGQREDSSTTRQGDSSTLGGDDSNLDTETSLGTYRETVDMPSKVVEDSAKTDELLQRPNVIPDDVLDSEQNLEGSVLSSSNQSSFDTDSPSLTGTPELSPKKKSKRRVPLLNVTLPSFGKRHHRLVKSPEQSSDSDRPSSPSKKFSWKKKNPKKAAVSPTSLSCGSTEEKILKDADAGKIEALGAEEKNHSSKEEAQVDFKMDNTSCLPGVPSMTVDHPERRGDDRVVLPSDEKVATGVVSCEIEDAGQEGGPPEHDGEEDPQDPRSDDEEETRGTSNEVQAGDGNEVKTQAVEELQEEELVGEMETSTNVRAEPLLTLSGLQDHSYGESPELASDGREDAKDMQEEDLQRDDEQTGLPEDDTADAQDEESIAVPTGLNLKGNIEMSASLEVNVSSTHHVSSPSDFILTTESFEVGEAVEEDAKVRSPLQDGVTGELAAPEKILAECNQLVADDSVGDVQFTPEMLSEFTKTIDAFEEEEDRDAQLDAGEAKGLTVDARDETERDSQKDVGKVEGLKLDTGGDEEALNVEAEGHFEVCLSDPLANDMESGPVDVGCQMTWENDGDENEDHQKVVGIDGNSVITLDLKCKQEVSEDDDKRSISSSMSSSSSESSAKGTSGEIVIQGVASIEDEATPNIKIQAATQPSEVVEVEDITKVPDAEGLSAPAVGPRSVQLSVGELLPGPDDSTSVEVPSSTVPEIQLHLKELSSDSDAEGEKRIQVVMNEEGSVDTTEEVPSKPVPEVKQKTKSKGFFSGFNFHLPRFRGKRSGKLDVATKSNQPSVGEGKISFSIDKERETCDKIQAESSRVSKASSELDISRRRSAAGYDECVLDNRAPSVPDVSQRELELKRSKKKSFTLPNMHLHLPRFSGKKSPKSPSADKVIFPSAEVTAKPPAIEGNPALEDEVQIEASTCISPVKSCEAEILAENDLEVKMSSTCSQEIAIPEVQHSSFGAVEVEALTALDGIADFSGKEVSIDVSTACGKPQVDGLFVAVPAFVEGDSDLDEGVPSLSSEEIKPAVTANLEANLEADDNSKLQAWGLDVNVPSVVGIQPEVEAKPETNSATRDQDGSPEAKANIPVHVDGNIDVIQTESPAVHSEKADISVGPGVSLSSGGMTEVEVDPPCNDKNDVEVDGEKVEDLQSPIDVNLCLSGSCSADVPVDDDFKSDLPEVAGVKVEGDVMMEEGSDGTLDLKAVGEGEAVDVELSAGLELSAGSRDASLENQVKTADLSTEVEGMIPDMSHRQSKSPDPVNSPTRHRFKLSHLNFSLPKFGGLHPATKKSSSKKSKTVAPPSNEACGVECGVASDDDEQERGFQQVSVIATNDSVEVVPQPVLESELKASFVKPEEDIGVDLEMRFGGLAGKGEDPINTAKDDVRAKLDFDDEIPPEFSANANELEQDCSLSGLHDLGVRLADISFGAQVSPSYPNGDADKDLCECRAGTPSQEDPASSLDLNWEDEVCPKVQVTVPKYRFTDIKGGLSLGVVVSEDGSTHSDTEEKIPRDEEKEAADDTVMYTPKVPDMAMKSAEEHNLEMTSASPQPEALDVNISVETPSAHRKQSTSSHSSAKSASSHNSQTNAGELSKKKGGLLTSLGLPKLHLKLSPQRSKSLDRRAVELEHPVEPRATSPTDPEAGAHAKKPVGKKSKKGRWKLGKSSSKGKHRTRSGGSAERLGTETEKRPLKACKIDIDGNLEGTAEADIYGQPSFELNPQPSTSAGPAASTPVKPALSLNNSSNLAPATPTSTNSLCMEQAVAIHSSPGSPVAPSLAPRRPFGVVVAIDFGTTFSGYAYSFCQEPDDIQIMRKWEGGDPGVTNMKTPTTLLLWPDGEFHSFGFTARDSYHDMDHNEALRWLYFDKFKLALHKDPNLNLETELTAANGQRLPAIKVFEHALRFFREHAVEELCDQSNDGRFDPGEIRWVLTVPAIWKQPAKQFMREAAYRAGLASPSFPEQLLIALEPEAASICIRKLRMRELVPEHLSQRRKWMRDNPEKSNSQVAENIRHGTRYMVVDCGGGTVDITVHEVEEDEGGSLKELHKASGGMYGSVCVDAEFEKLLVEIFGEDFIEEFKIKRPAGWVDLMIAFESRKRNVNPYKNNPLNVSLPFSFIDYYKKYTRETSTVEDAIWNYRSQNVTWSAQVPGMLRFTPEGMQQLFRPAVASIISLVEGLLNEPQLKGVSYLFLAGGFAQSPLLQNQMRKKFASRLRVIIPRDVGLTILKGAVMFGLDPTAVRVRRSRLTYGVGVLNKFVPARHPREKQVVKDKVEWCKDIFDTYVQADQSVAVGDMVTRSYTPAKPSQKAIVINIYCTERDKVDFITDRGVHKCGTLHIDVSDAPPSGASPAKRRELQLTMQFGDTEIKVSALDVPTGKCVKANIDFLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJL3</accession>
    <name>A0A8B7XJL3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neurogenin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080371.1">
        <property type="nucleotide sequence ID" value="XM_022224679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJL3"/>
    <dbReference type="GeneID" id="110973681"/>
    <dbReference type="KEGG" id="aplc:110973681"/>
    <dbReference type="OrthoDB" id="5969565at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11390">
        <property type="entry name" value="bHLH_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050359">
        <property type="entry name" value="bHLH_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19290:SF164">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="135"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080371.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29943" checksum="F5BE57BB09D3F6E1" modified="2022-01-19" version="1">MSSLDHHQLKVEPNDDDFFHTAASAQHPNDGSQFDMYDQPDSTLTILQDTYQVPFHAHTPYTQAVNGSLIGSPGGGSENFGKMSHPRRHKVPSAKSAAPRYHGGANSTGTTAARWDSDNCRRTRTTHNGRRSTSERRDRINERERDRMHMLCDAFEQLRQVLPIKRPKRGPHRQRLSKISTLLFAQNYIRTLEDILRNPAEYADCQLSPSDDAHSGNSACRSVHPSPAPTCDVSTEADYGALFNPSEFFHQKFSNDVFVDPAYVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJN6</accession>
    <name>A0A8B7XJN6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LOW QUALITY PROTEIN: germ cell-less protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110973570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080170.1">
        <property type="nucleotide sequence ID" value="XM_022224478.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973570"/>
    <dbReference type="KEGG" id="aplc:110973570"/>
    <dbReference type="OMA" id="TGFNYGM"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18305">
        <property type="entry name" value="BTB_POZ_GCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000092">
        <property type="entry name" value="Germ cell-less, spermatogenesis associated 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043380">
        <property type="entry name" value="Gcl-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23231">
        <property type="entry name" value="GERM CELL-LESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="BTB" evidence="7">
        <location>
            <begin position="65"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022080170.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="55884" checksum="9A226CB9A11D8A4E" modified="2022-01-19" version="1">MGGYVSVPGWLGGREFSPKQKKKRGRDDSDDDSEEDEIMRTPQRKKLKSTSKYIYDTLFVNGENSDITIFALGKEWYLHKIYLCQSSYFASMFSGSWKESNLKEIKMDIPDSNIDIAALEVALGSLYRDDVMLEPAKVVPILAAASLLQLDGLICQCADIMTETISTKTVCCYHTAASAYGLELVTQNCISWLEHNLMDMQRASLLRELSLELFEKVIRSPSLFVLQVEMDVYSLVKKFVFLKLMPSWNGNYKNLSKDADMLFRAYKPGEFLETERGKKYVSLFRGVRLQHIINDLAASKHIEKDHIITNEWLLPVYQQQWQCMLGLEQGLNQGPTEEAVSAETFNQLSLRCGRVISRETDVIXYQHGNNWIHIQIGLSLDHRLLIFRRNTVTHPVLASVSLQNTRNIMFRVRVISYDSQGHVLYQKRSHLKVLSLSKDEEAVVLNIDKHVQFPMRVSVNMLCTTPTGMEESAEDPAPAPSQPIGREEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJT5</accession>
    <name>A0A8B7XJT5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110974049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081063.1">
        <property type="nucleotide sequence ID" value="XM_022225371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJT5"/>
    <dbReference type="GeneID" id="110974049"/>
    <dbReference type="KEGG" id="aplc:110974049"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF46">
        <property type="entry name" value="ANKYRIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022081063.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16179" checksum="DAA67D7DBD54B808" modified="2022-01-19" version="1">MAATMEIMRELKSLGKMKVEVPTNHWSSAEFKRRQKQILDEIFLCLMRGLVDGCYDENGLNALHLSSKEGHLNIVKELLKRGANVDAATKKGNTALHIASLAGQQPIVEALVEHGANVNVQSQIRKDQPRRHGVQVSYWEMFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLF3</accession>
    <name>A0A8B7XLF3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat-containing protein 34-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110973890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080790.1">
        <property type="nucleotide sequence ID" value="XM_022225098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLF3"/>
    <dbReference type="GeneID" id="110973890"/>
    <dbReference type="KEGG" id="aplc:110973890"/>
    <dbReference type="CTD" id="417211"/>
    <dbReference type="OMA" id="SYVCAWN"/>
    <dbReference type="OrthoDB" id="445052at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097014">
        <property type="term" value="C:ciliary plasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF26">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 2 INTERMEDIATE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022080790.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="50387" checksum="EE590591B7729A24" modified="2022-01-19" version="1">MFTDEVLDGEEFKSSWKRERSTKSSGSQTSEILTGESDAQTSYKSNAKVQTDPIKEKKFELAADNSQAFQDFIARVTPDICHVLERNARSHAFDGWDVNWEEDTEAVTCQYKLCHAPLRGELQCTRVAWNCTGSSLAVAYGRMDHQDWCTHRGSLCIWNIDLKSIDREKADTVVDVNSCLMCLAYHPEKPSAIVGGNFNGEVLLWDLTREDDGLLATSGIGDDSHREPVSEVMWLQDPKRSNKYNIVSVSSDGQVLVWKVNARKGALELVEGFLLLASSLPAMLGQPKAKGEGEMGVNCISYVSEDKSQYMIGSESGGVFKCSMNSTVPVPTTEVLRSVPLHNPVVFAFHPHHGPVHSIDCSPYHRNLFLTCGMDAEARIYSMLESRSIISLEPSAGYLFCARWSPIRPLVLAVASSEGKLLIYDLKTSRINPVQTLEASPKKSALHTLEFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLR1</accession>
    <name>A0A8B7XLR1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080905.1">
        <property type="nucleotide sequence ID" value="XM_022225213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLR1"/>
    <dbReference type="GeneID" id="110973951"/>
    <dbReference type="KEGG" id="aplc:110973951"/>
    <dbReference type="CTD" id="51076"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.380:FF:000001">
        <property type="entry name" value="Copper homeostasis protein CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080905.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="26629" checksum="440618C6B71A2B50" modified="2022-01-19" version="1">MEVCVDSVRSATAAERGGATRIELCAGLSEGGTTASLGLLRIVKAVTTLPVFALIRPRAGDFLYDPEELEVMREDIQLCKENGADGIVFGALTSSGSIDTEVCKEFIGIFQINRHLMSPILPAFDMCRDPHASLEVLISLGFERVLTSGQESSALEGLPLIRELIQIANNRITVMPGGAINARNLDRILTGSGAKEFHCSARSIQDSLMVHKNSRVTMGAQLAAPEFSLKFANEELIRTLKDIQAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM40</accession>
    <name>A0A8B7XM40_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110974038</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022081035.1">
        <property type="nucleotide sequence ID" value="XM_022225343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM40"/>
    <dbReference type="GeneID" id="110974038"/>
    <dbReference type="KEGG" id="aplc:110974038"/>
    <dbReference type="CTD" id="10425"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20344">
        <property type="entry name" value="BRcat_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20360">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16773">
        <property type="entry name" value="RING-HC_RBR_TRIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000004">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047555">
        <property type="entry name" value="BRcat_RBR_TRIAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047556">
        <property type="entry name" value="Rcat_RBR_TRIAD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26000">
        <property type="entry name" value="UBA_ARIH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="133"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="137"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="298"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022081035.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="56801" checksum="CE5D55CE3F8AEA45" modified="2022-01-19" version="1">MAEGSSRLKTPPVRMESQSDEYEYDEYEDFDAYYDEGQDEMEPEDEREPDPECYEYSVFSVDEAKAYLAKEVQTAADALKVPCYAAKALLMSHQWNLDAIQSRTKQDIANLLVECGVLPSADSSLTKEPAIPSNYVCPVCIENQSKEQLRSLLCGHFFCKDCWSQHVVVLVNEGSSTGICCMAEKCLMRAPEDFVIPLLQSEHHKLRYNDFYFKESIKNHSSLRFCPGADCTIVVYAAEVKSKRVECTQCKTSWCFNCCNNYHAPADCDIIKKWLTKCADDSETANYISAHTKDCPVCNICIEKNGGCNHMQCSKCLHNFCWMCLGDWKTHGSEYYECSRYKENPNIASESANVKAREALKKYLFYFERWDNHAKSLRLEKETLRKSQERIQEKVENKMGTWIDWQYLLAAASLLAKCRYTLQYTYPFAYYLEPSPRKKLFEYQQAQLEAEIENLSWKVERAASYDRGDLENQMSVAEKRRQTMLKDFFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN98</accession>
    <name>A0A8B7XN98_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MAP7 domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110974375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAP7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081652.1">
        <property type="nucleotide sequence ID" value="XM_022225960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974375"/>
    <dbReference type="KEGG" id="aplc:110974375"/>
    <dbReference type="OrthoDB" id="6162626at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008604">
        <property type="entry name" value="MAP7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF1">
        <property type="entry name" value="RETICULOCYTE-BINDING PROTEIN HOMOLOG 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05672">
        <property type="entry name" value="MAP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="938"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1166"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1231"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="539"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="605"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="637"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="985"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1047"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1166"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1259"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1296"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022081652.1"/>
        </source>
    </evidence>
    <sequence length="1425" mass="152620" checksum="FA7956A268C1D397" modified="2022-01-19" version="1">MADNTGVDDGPFQPKSESEAITLTNADAPADSTDPGATVNPFQSSESPPVIPSDPITNPAPDSPQQDFSEPPQCLPQSNAAPVLLVTGETASNGDLDSSEPDTPYPEGQAGSDIVGNSSDSSVSENAKVKADGSVDPSSELTSESNGDRSRQDSGSTEGSRRDGPPTRSRAQPVLDASKLKEKENKNNQFRQQQLSDRQKRIDSIRHKATDHRAEILERKKKQEEEDQARKEAIVRRSRERSDNAREKRRSWSAFGSRDYSSPVPSGGTPRSSRGRSTDRMTERQSPDGSLTLGASKRLSSSVSALHRPVHLVRLGPNEDDWFEVHIPDPRSRRGSSPGNDKNPDSSSTPLPASSSTIPRHHLSSPNLASSNVRRRLRAAYPNRDSRSAHSTPTHVSRPLSATKRSNSNSKLDSESGPVGGKPASGTAPAKRGTSPRTSLHGRPPSPRQQSSTPRATPVRAPSPKTAAGQGSTTVDGSKPRPGRVQSPRNLPKQTNGDSSRKPPEGKKTPGQAPPIKKALTPRTDIVKSTVSSPTRTVTAPKSTPKAPATKPATTPKGGPKQAKPAAVKVAVAAAAAPEKPAPEKPAPAKEEVEPETKPKETPRSQSPTISESSSGSAPAANGTASPAAQAPPPAKELTEEERAKQALAERRRQAREKAEREAELEKQRQEQLKREEEERIRREEEERIRQEEEELRLAEEHRKAEEERLKQAIQEKEEKERLEAERKAAEEAEAALRAEEERLRQEDLKRQEEELAEKCRREDEERNARKKRVEEIMKRARRGAQAKDKDDGSENGDSGSESGSATGSERKTNGVNSMLASSSVLNSEKYRNLLFNRNKTELSGDEDEDYEGGQLEGTANGGPANSSSDSDDRDGMELGGGAGPVDLLPGDKPEWSDEEAKQVDGEDFMEVLDSDAGFQGDINVLERGVVMEDDLQEKQELPTEPADGIGVGNGEVSDKGVAKEEDAAEMEGVAREEDVAEVEGVAKEEDVAKMEGVAREEDVAEVEGVAKEEDVAKMEGVAREEDVAEVEGVAREEDVAEVVGVAKERPELKGPAEEPPPPLDDDDVVSDDAVGALGVGKEGAVEQVVANEGTDSKGFTDQPLLDDYGIGKDAVTDEGFVKEEGVVEDVADKETASKVFTEQQPPFDNYGVSSDVVTDEGVVEEGGADTEADSDTFTEQPASKDYGIGSDEISDGVVKEHVAKEEVNSEVVIEQQPRFDDCSVDSDAVADVGVASEEGVVKEDIPVDLTTNGNGNIDPEDQEDISSDDEKSDGSSRNGNELEPPGLTAPPLNNVPASDNNFNNANGETLIDPAPESTELITKKALLDFDDGGGTLDDGGTIEMGQELSPDSASDKLNANLGMMAGFPVGDAPTTLSFSPMGELESNGGQQPQPMAVCLTPEGTTPTCDIHGPCFWHDCLTDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPB4</accession>
    <name>A0A8B7XPB4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110974973</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082658.1">
        <property type="nucleotide sequence ID" value="XM_022226966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XPB4"/>
    <dbReference type="GeneID" id="110974973"/>
    <dbReference type="KEGG" id="aplc:110974973"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022082658.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17534" checksum="12024C61CCBA36FD" modified="2022-01-19" version="1">MDKRGRVGPRDPSCSNATISTTSTISTTSAISFNSTASFINSITSLLSQHHLSYTPWPNSFLDPSLTPRRSGGSWTAAWLTNTPCGDPLNGKWMLNMSIWSKTEVKSIDLTMSDDDLYLYFIRRRRRVFAGKPGTRSTQPGTRSTKPTHPTTQRGPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR09</accession>
    <name>A0A8B7XR09_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM167A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM167 (SEC) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083278.1">
        <property type="nucleotide sequence ID" value="XM_022227586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR09"/>
    <dbReference type="GeneID" id="110975263"/>
    <dbReference type="KEGG" id="aplc:110975263"/>
    <dbReference type="OrthoDB" id="5965452at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024280">
        <property type="entry name" value="FAM167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051771">
        <property type="entry name" value="FAM167_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32289">
        <property type="entry name" value="PROTEIN FAM167A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32289:SF1">
        <property type="entry name" value="PROTEIN FAM167A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11652">
        <property type="entry name" value="FAM167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083278.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29582" checksum="749CF0E2B7E9C79D" modified="2022-01-19" version="1">MHARQAFAMIMGPSQAMSPYAIPSITISPPTSPREGVYQKRGASSDLATIDEADPSTTDGPCGLWTATSLCSPSNLLSPEYTPPSAPCGGEKSSEHEDELAKLKSMATRLRLSTRRPSYVEWCANLPKLRDLNGNLTAKKRCQDRSDDWRTFKQRRDCLEEKIQWVRNELIEMKSQDHRLAIQLMRLRSEIQQLRLQKSCHEHRELIDTATECAQEDRDSQLQPALCDPPFRGNGVLLALEKPLKDVGVTRLNLFARRFSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSE6</accession>
    <name>A0A8B7XSE6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Serine/threonine-protein kinase STE20-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12" type="primary">LOC110975065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082876.1">
        <property type="nucleotide sequence ID" value="XM_022227184.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082885.1">
        <property type="nucleotide sequence ID" value="XM_022227193.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082895.1">
        <property type="nucleotide sequence ID" value="XM_022227203.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082903.1">
        <property type="nucleotide sequence ID" value="XM_022227211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSE6"/>
    <dbReference type="GeneID" id="110975065"/>
    <dbReference type="KEGG" id="aplc:110975065"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="296"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022082885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022082895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022082903.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="61082" checksum="0BD4452E929422CA" modified="2022-01-19" version="1">MSTSVRYKEPSQPADTGTDSNGASCLVTASSEKQFRELLKRVLLVMDGALSDLLPACRLWDHNLEVFSAKDNESGSHGSGKEFSSANKGSRGQDCQTPRSGQTSPPTQVPKSSGGGGDDGDGSRRPPSGADKKKLDCDRPSENKTKKKTAEEGESDSAEAELGSGDEAAGQPTENGMQAPNMVGAALEEEFEPSPELDQGRNFQGARNPPFQSFLEDQNPPLPLESWLPEGGVVRPDRSAAVGVMQGDCGQLNEAARRIDHERDLDPAILAEVQDGVLMDEGLIAENGHYIENDQFLKLEQIGKGAFSKVFLIEDNQSKKHYAVKCVPLERFFLYEVLLWSDLEHNNIGHLRGVVRTGSEVLLISKYIPGQTLEQMVTHRVLSQGEALKMVRPLSCGVCYLHAKDVVHNDIKLDNIIGEPCRNSLVNPVLVDFGCAMRRVHVDMEGVNQLTPDVDGVMHALISILQGPKRTPRARIPPSTDERLKQFIKGVLEDPERSAAKTLENWPHHLEEELDSVPAVMDDEGLDEASIGVQTLPDENPRPCEPPRAEWDICGFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTY0</accession>
    <name>A0A8B7XTY0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">ADAMTS-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC110975818</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084312.1">
        <property type="nucleotide sequence ID" value="XM_022228620.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084313.1">
        <property type="nucleotide sequence ID" value="XM_022228621.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084314.1">
        <property type="nucleotide sequence ID" value="XM_022228622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTY0"/>
    <dbReference type="GeneID" id="110975818"/>
    <dbReference type="KEGG" id="aplc:110975818"/>
    <dbReference type="OMA" id="KPCEPRW"/>
    <dbReference type="OrthoDB" id="10062690at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PLAC" evidence="8">
        <location>
            <begin position="1125"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="650"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022084312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022084313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022084314.1"/>
        </source>
    </evidence>
    <sequence length="1161" mass="127258" checksum="E808B13CC302D205" modified="2022-01-19" version="1">MWTAVKHEQGMSPPAPARRGHGTTVPVQDHSFQTSWASERRMTGGKIYCTRSKVVSCRLSRLILQWLVLLSHMYSTQGLSELRHQLTDTSLNTTAETSSSHWSEYGLWSACNGNCSYAIQYRDRRCLNQRNDFLDSRFCVGSARQYRICRTELTQPCPNPMVLRSELCTAHRESNVTWQAYSHPSVGTCQVACYARKVKASTRAYTVLDQGLPDGTPCSKYRGCDWWNRVSQSQGICLQGQCLDVGCDGTINSTKALDSCGVCGGDGSSCRIVSGRFTETLQGVSTEVVEIPGGAFNVRVYEVEKSRNHLAITDETGRPVLNSFLGIWNPGRYEVAGATATYKRCGVSRFSPGHYEEILIHGATSVKIIISILSREKYTPVHVAYQYSLPLPRSHGSQTTASPTTSVTLEVTTEVAEVIELMTTLATEESYSSGTPFARQGHQNMHNVIAVKTLSYSDDETEADSGSQGTSDQLPSFSQGRSKTSFLEHSTSTEVTKPAAVDKTDMYMEIQNESSGYKQNVDTPDSEDTLENTLPENGNSTSLHERPSTLAKPADMFSETQGNDPWVENVGPEDKQGILPELETSGHLDESRGQTTLKQTSQYISSDSFVPENSTQIIPVTAEPPLSLDPEQPANSTVASSIPSSSPSSGQTDSLENDLFQNRDGNPYVTRHQDEGRGSRSFSEPTNIPATSTQRTITEKDLDDLPDFPLEHRPSMVESTELLFGEVPQIMELIKPSPESLGQAAHPSTASGATSIVISRGDVPEEERRVKPRYLWARTGVAPCSTTCTRGMSRSYAYCTLNGEQVPDNLCDPASKPEVVERECGGKPCEPRWAVGRWSQCTVSCGTGAVYRTVHCWLMIAPGLDTSISNAYCNQSNVPDSVGTCTQSPCGPQWQISDWSECSVACGEGTQTREVHCSAEDGSCNPTLKPSTTKRCFIPTCPSEWTTSRWSQCQGPCTIQHRRVDCVNSRGIIVGANTCPTDSKPLSHRLCGEGCPAQWVAQSYGPCLGDCGSTVRRRRVICAATSAVSGRMQVLANSVCSASQRPGTETSCQLVSCQSRPTRRRRQTPQWLTTPWSVCSVTCGNGRRTRQVTCNRKRNQSHLNCNKDKEPDSWEPCAMGDCPTVNPACSDSPKADCNLIRRANLCRYDSYRRSCCLSCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUG1</accession>
    <name>A0A8B7XUG1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110975598</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083877.1">
        <property type="nucleotide sequence ID" value="XM_022228185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUG1"/>
    <dbReference type="GeneID" id="110975598"/>
    <dbReference type="KEGG" id="aplc:110975598"/>
    <dbReference type="OMA" id="GRCAVEC"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695:SF12">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apple" evidence="1">
        <location>
            <begin position="14"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022083877.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27452" checksum="AA5CFA3A2737FCD3" modified="2022-01-19" version="1">MKYVYVIIIAVVCCSEIFIALATGTATSSSYFVLAEHGKYKTVQHRAIASSVQETRRHCAAACLQEDLCQQFCYGPSTGQCVLEDASFMSLSGRGTDNCTYYSRQVCNSSYHLTSFHEHMFPFPAFNGELVLDASVLCRARAMIIFSGDGTKAGTKYQIIFDQATRMRRCTQCSQLISVQTPDVLSKYEMRRFWLRYNQGTFTLGKHDEAPFLQWTDSTPQAPLFVGFSNWDFPATWVVHHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUX5</accession>
    <name>A0A8B7XUX5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">small monomeric GTPase</fullName>
            <ecNumber evidence="2">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110976031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022084658.1">
        <property type="nucleotide sequence ID" value="XM_022228966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUX5"/>
    <dbReference type="GeneID" id="110976031"/>
    <dbReference type="KEGG" id="aplc:110976031"/>
    <dbReference type="OMA" id="MIAIKHT"/>
    <dbReference type="OrthoDB" id="18798at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051065">
        <property type="entry name" value="Ras-related_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45704">
        <property type="entry name" value="RAS-LIKE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022084658.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27686" checksum="D817E97E26A82990" modified="2022-01-19" version="1">MIAIKHTLPVVKFNSASMFPLNVVKKSLRGFVNMSSGSKKKLDRLKVAVFGRSGCGKTALTVRFLTRRFIGDYERNKENTYQQDVDIDGTLVNLEILDTRLDIQECFEVTTSFERTVKWADAFIIVYEVTDAKSLRVVPHIKAAIDQARRSKTLPAILVGNKIDLVHSRVVTYNEGLELAQLLGMPFFEVSVRESYEDVVRLFSALSGEFRSLTTKSSVFKGFRDRSKKKGRFAMLTRQRSVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XX25</accession>
    <name>A0A8B7XX25_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="17">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110976111</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="17"/>
    <dbReference type="RefSeq" id="XP_022084812.1">
        <property type="nucleotide sequence ID" value="XM_022229120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XX25"/>
    <dbReference type="GeneID" id="110976111"/>
    <dbReference type="KEGG" id="aplc:110976111"/>
    <dbReference type="OMA" id="GYWLEKT"/>
    <dbReference type="OrthoDB" id="28230at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01238">
        <property type="entry name" value="PH_Btk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11768">
        <property type="entry name" value="SH3_Tec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000052">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001562">
        <property type="entry name" value="Znf_Btk_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51113">
        <property type="entry name" value="ZF_BTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 17" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="21">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="241"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="19">
        <location>
            <begin position="311"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="430"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00432"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022084812.1"/>
        </source>
    </evidence>
    <sequence length="692" mass="79636" checksum="358C654AE1EA6B23" modified="2022-01-19" version="1">MANEIQEICRISEMLKRSQNKRKLAPVNFRQRVFILTRNDISYYEGTKEKQGKEKGRINFSNIKVVEEVDDSALEKPNGIQISYDDYTLYFFASTKQEQKEWLSDLQIACKNNVTLQNRFHSGVHNTKWWTCCEQKHMGAPGCKDSFKHRVQPVAQPPTPRIAPNNSSSLPTHALRQQGPANGQLGAKQRGYHSTNAVTHNHLPNPATSMSLQTSPALTQPHQLNRSHLPLPRPPPVVPKKEDLIVIAKFDYEPMEEVDIPLVRGDEYTIIDNSREYWWKARNKYGNVGYIPSNYVEEKSKFASGLEKFEWYSGKWNRQRTEQELKAEGKEGCFMVRNSSTKGLYTLSVLTKAMMHGRDDSVSHYHIKQTAENQYYVSEKHCFNSIPELIEYHQHNSGGLVTRLRNPPGHIPPTTAGLGSGTQEVSWKDLTILREIGSGQFGVVKLGKTKKQNRFVAVKIMRENAMSEEDFIDEAKVMTQLQHENLVQLYGVCKNPLCIITEYMSKGCLLFHIRRHQELLHEPHILLDMAIQICSALAYLERKKFIHRDLAARNCLVGERNTVKVADFGLTRYVLDDEYTSTGTKFPIKWAPPEVLHFTKFSSKSDVWAYGILLWEIFSGGKTPYPQMNNVEVVDQVTRQQYRMEQPAMCPSSMYSVMYYCWHEKPEKRPSFADLMQLLTQLQDQESTDFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY26</accession>
    <name>A0A8B7XY26_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Extracellular matrix protein FRAS1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110976154</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FRAS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084940.1">
        <property type="nucleotide sequence ID" value="XM_022229248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976154"/>
    <dbReference type="KEGG" id="aplc:110976154"/>
    <dbReference type="CTD" id="80144"/>
    <dbReference type="OMA" id="NSGMRVQ"/>
    <dbReference type="OrthoDB" id="430044at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2030">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF1">
        <property type="entry name" value="EXTRACELLULAR MATRIX ORGANIZING PROTEIN FRAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00093">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00215">
        <property type="entry name" value="VWC_out"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57603">
        <property type="entry name" value="FnI-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01208">
        <property type="entry name" value="VWFC_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50184">
        <property type="entry name" value="VWFC_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034751956" evidence="9">
        <location>
            <begin position="31"/>
            <end position="3988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="3867"/>
            <end position="3889"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="10">
        <location>
            <begin position="30"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="10">
        <location>
            <begin position="96"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="10">
        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="10">
        <location>
            <begin position="222"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="10">
        <location>
            <begin position="287"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="VWFC" evidence="10">
        <location>
            <begin position="351"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1094"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1209"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1320"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1454"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1582"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1695"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1819"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="1942"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="2063"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="2185"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="2297"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="6">
        <location>
            <begin position="2425"/>
            <end position="2522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="3895"/>
            <end position="3936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="3895"/>
            <end position="3910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="3921"/>
            <end position="3933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022084940.1"/>
        </source>
    </evidence>
    <sequence length="3988" mass="439874" checksum="47DDF041129191E5" modified="2022-01-19" version="1">MTKSNVTRTCYASWILLGASILLYAARVQGTCFYEGLHYANNTVWEVDPCTTCSCLGDLVICEPKQCQDPRCDFQGGETLRIQPNRCCPECAPGAGSCEYQGEIVGHNSQWSLSPCRSCYCNNGVVQCRNQSCGITQCRPGEVLHQLQDECCPRCIRPGRSCTYRGVPYRDGAEWSPVKCTKCRCDNGMSRCFVADCPPLFCGQNEEAVTPPGKCCPECVGQSCELDGLIYKDGSQWQADPCTYCKCYAGSIECKQLRCAQDFTCRQGERKVTKEEQCCPECVSAEAPCNDVGTLRYSGDVWNVSACEFCICQQGRIDCYAAECDRLRCEVGESLVHREGRCCPECVSPVGYCVHNRITYTNGDIWEPDDCRTCVCEAGHSNCFKVDCPPCAGDRVPVEVEGQCCPDCILVQCRPECLTCDARGCLTCRNQRLVQNGRCVDSCDIGFYKASQTLCQACHETCLSCTAGTEFHCLTCADTLLLKWSQCIVDCGSGFFEQDGICIECHSSCQECTGPRKSDCLVCSNSTHVIRRNSCVPECGQEYYLQGNYCYPCEPSCFSCHYDNPRCILCPANQLLRDGSCVTECGAGFYQASSTHCEACHHTCQYCRGPSIYECMACDEPFHLQDGQCLYNCSNGFFDNENTCTPCHPSCRTCLGPAADDCSSCRDASQVVQGRPPFYDVITGPCTARCQESFYADIHGICIPCNPTCLTCTGQSINSCTSCRPPLLLQNGRCEKQCSDGQYSENSMCLDCHPSCRVCFGPAPNQCLACHQGDTLQLGTCSAGCPSSQFANDFGVCQDCDSACGTCFAAGEGLESSTCTECADTGVYPLGDTCVSECGIGHFLEAGTNMCKACHISCRTCDGPSVFDCSTCYSGIVLTHNGLCSSKCYGGYYDDGGVCKACQANCLECESPYECLVCRNPNDVLQFGECSPYCADQYYLDPVTRLCQECDWSCNACSGPTARDCTLCMENLMLKDGACVSACNEGYYVFLGECRECGEDCKTCSSPGVCTSCQPPRLLLGDQCVTHCGVSYYSDYGRHVCRACPWNCLECSTPDQCTNCASGSFLLRGSCEADCPSGYFTNPQLNICEANLYPPTLFVNGTLNSEIGGTTVLDTSFITAYDPDTASKDLTFVLISPPTNGELIKIQRGVDATLAAGDYFTFPELDQGSVRFVHDRRQQLTGFFTLKVGDRQFQSPPEDIGIVVLSPLAPYVTRNQPLVVEEGEMGRIASDANLHIRDEDNPEMVTITAIEGPRHGRLIKLPDRSRAKTFTINDLVAGNIRYVHDGSETQYDAIAFQVTDGHNVINVLFYIQINPNDNKGPILINNVLMRVREGDLIPITSDHLKAFDVDSPNNELMFTLTPPKGNPRSGDIVMVLPIPDAGVPSGWEDMQNGYMMQLLVRFAQEDINQGRVYYRHSGGEVTSDYFMFEVADTAHNVLSDQAFNIEVLPNNDEPPRLVAGIVEPLLMRVFEGEITPITNTHLAYTDVDSPDPDLVYNITTPLQIGQGSIEYVDRPFQPTDLFTQADINAQKIIYRPPNIDLGQEPLSFKFFFTVADSVPGGNLVGPKPFTIFVLPREDKVPPTLDNRFHTFEVQRGGLKQLRSILAEGTNLDTPQTDLVYTLITAPEHGFILKSGFIQLDEGAQFTHAELLQESFHYVHDSSQTEQDSFEITLSDGTHSASIVMAVVVTYTDTRKPSVRRGATLSLLVPENSMAVVSRDELSFEDDDSVDSEIVLTLDTLPHSGRLQQRIAGDFYQDIPVGGSFTQADISAYNIRYVAEGEIGSQAVTDLLFFNVSDASGNVLIKQVFPVTVTPVNDQPPSVTVGDGIRLVEGARELISSANIRATDLDTRLSQLKVIIDTGPTFGFIENIRSALGSEQPNVDIPVTDFRVQDLIDNTIYYVQSVHRNVEPTQDGFLFHVSDEENDSPQYRFNITIRLVNDEEPMLITDTLFLPENEGAVVTNVSMYASDLDTGPEDLIFTVTEYPTCGTLRRRAFIGDPLHFGRILTVGDTFTWRDVLDELVVYVHDGSEVKTDSFGVSLTDGIYTVLGTVPIQIGLINDETPRVAVNRGLQVQIGSTTTITNYELRAEDVDSENMQLIYTLTAEPTVGQLQFLLNGENMVPLRVNGEMSSFTQNDIDNGYVRYVHDPIEAAGTAVFKFTLSDPEGNELIDQSFLITVLEDRVPPQILANRGLTLAEGTSKVLTTDVLSATDVDSVPGRLVYLISAGPTYGQLEFADVPGVPVTEFTQADLAAKTVAYVHTSEEEAVMDSFTFTVDDGTNQVTQTFYITLTPVDDSLPLLTNLGMRVQEGVRKSITEFELKAQDMDTPADSIMFTIFRQPQHGTIDYTPDEARYAPTLTFSMTDVYENRISYSHDGSNTLEDSFEFTVTDGTNPLFIIEQGTELITTSAQQTFQITILPVDDGTPRIITNLGLSYLEYLDEQAMGIITRKNLATMDADTPDNLLVYTIRTPPNHGILESTLTPGTPITVFTQEDINNGIIHYALNPGAEPELADRFVFDVADSKPNTVSGTVFRIRWSLIHLERGAYNVSETAGVISVPVKRSGNLNQYAIVLCRTESGFATSVGGQPGERDYIEQAVQVQFEEREDTKLCSIVINDDAVFEGLEDFIVELSMPAYALLGDPTAALVTITDDEDEPSIEFDQLVFHVNESSGFLFAPVTRKGDSSRSVSAICFTIPGTATGSSLTGLESGSDYKTRGMDGEYRVVFPAGVNTASCDIKIIDDAMFEAEEEFEIALAMPSLWSRLGRKSRAMVIINGPNDESLVSLSQNTYIFNENAGTVEIEVVRHGSDLSHTSMVWCSVKPSDPPSATPGADFVPSTSQLTFGPQQTVEVCRVTIVDDTASPQMEGNETFVVYLSSAMGSSLATPHEAIIVINDTVDDVPTMQFSLSEVKVEEHQGLVHIPVVRSGDLSFESSVRCFTRQHSASVMMDYDERRNTDEFRIVFAPGEKVKNCTVGIVDDQTYEADEQFRVRLGDPIGSEFCHAQIGKNNSAMITILDTEDAPTVQFERMAYSVREPSDPDEMSVVTLTVIRTGDQNRTSRVRTSTRDGSAKSGVDYEAHFKVIRFRPGVRSVDIEINIMYNKDMEWHETFSVVLGPDDPVNALLGPITMATVTIIDEEAAGSVVLPSTPLVVSLMDYDDIADSLDHDPAPGYPLICVTPCDPHYPDYSMTRSICEDAGINISNIHYNWEVAMPTDAEGSRAPFERVVDYTPFTAPNEKVLDSVYFSRRFHVRCMAQPYDRSGRPGVPLRSNIVEIGTDNGICHTPVTAGVARGIQAQSFIANLRYVDPTDLDHPNTLHVSVEIPHQDGMLPAISTVAIHNIRLLLTEPVYRQQHICSNLINNPSWGGLTDYSFLTPVDLDTMVMVPGNNYPYQFDPQLRGQKALNLYRHLNLKSCTWTFDAYYHMTELIDLCGGAVTTDFQVRDTDESYLTVTVPLYVSYIYVTAPTGWGALDHRTEMEFSFFYKTILWRTGLETDSVLSGRLEVLRIRIGDRGNLIIDFKTTTKFRGLFVMDHHTLPDYISRVVPPHELGVGFNLQQLWSEGTFDSPQQLWRATSTYNLKDYSGDYVIELLPCTVTPTQSFNIMPNMPVVCTAHPPEKFVVPIAFQQTNRPVPVVYSLSTEFHLMNNEKVFLMNPNDAAMSLQEMDYKGSFAKGQRIFGRVLWNPDQDLDRAYKLQIEKLFLCTGADGFVPYYDPDGQIYKEGPQLGCMQENRKLKHRFLILDRGDTDAVTSNFNDVPFDANFASNTENYNAVSNMPGVDGFIMKVDPLYKVQSGHQWYMQVIYTIGPSDSLPRFRRSLLASVPNPLNPNGHKPSSHHNGTNIKSLLLEEGDFEGGVAGSATGTVVPAVVGLLVFLALLSVAILLVARRLRSRRAASENRRHRKRRAAGKPAPKVANRDSASTKSLPNNKSPPKLQEIEMDMQKMVKVSTLNLHKPENLNTPAVKVKKVNLQVKLSNAGIEGGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY46</accession>
    <name>A0A8B7XY46_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dehydrogenase/reductase SDR family member 11-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085814.1">
        <property type="nucleotide sequence ID" value="XM_022230122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XY46"/>
    <dbReference type="GeneID" id="110976654"/>
    <dbReference type="KEGG" id="aplc:110976654"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43115:SF4">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085814.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34761" checksum="CAAD992991E185DE" modified="2022-01-19" version="1">MFPCSKIAPDIVSPSHKLSHSERSLWGPFCVRSLDIEWGQGHRQLLIIMASKEGMQRWTGRVALVTGASSGIGQATARALARHGMRVVGCARNIKPIEDDAQMLSGDSTVTGSLHAIKCNLMQEDEILAMFAKIRETFGGVDVCISNAGFSDSGSLSSQLTVLNGDAAKWRGIFDVNVLAVALCCREAVRQMEEKGATDGQLLVTNSMSGHRLTPKVNLFHAITKHAVSVLVEGIRRELREKKSHIRIAQISPGIVDTRSQERMQAGFYPEEVNAFYKTLEALRPEDIADNMLHVLQTPPHVQVHDILIRPTEQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYR0</accession>
    <name>A0A8B7XYR0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein SET-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110976315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085170.1">
        <property type="nucleotide sequence ID" value="XM_022229478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYR0"/>
    <dbReference type="GeneID" id="110976315"/>
    <dbReference type="KEGG" id="aplc:110976315"/>
    <dbReference type="OMA" id="WPVALMN"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000002">
        <property type="entry name" value="Testis-specific Y-encoded-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085170.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33995" checksum="4643878A1E21FCBC" modified="2022-01-19" version="1">MSSPPPAKVRKEETKNNGQNVAEVDEEDVNQMAVEAIDSVQSEIDALNEQASEEILHVEQKYNKLRKPHFDKRAEMIKKIPHFWVTTFLHHPQVSMLLDEQDEEALQYLTKVEVQEFEDIKSGYRILFHFKPNNPYFENEVIYKEFHLNDSGDPSSNSSTIKWKPGMDLTKRNTAVQQKGVAQKRPHGDSESFFCWFNDHTDAGADELGEVIKDDIWPNPLQYFLIPDGKEEGDEDSETGDLDDIAEYGEDDDDEEDEEEEDEGEDDEGEEGLEDFEGEGDEEEVPEDEEDEEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZV1</accession>
    <name>A0A8B7XZV1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Gastrula zinc finger protein XlCGF7.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110976381</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085281.1">
        <property type="nucleotide sequence ID" value="XM_022229589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZV1"/>
    <dbReference type="GeneID" id="110976381"/>
    <dbReference type="KEGG" id="aplc:110976381"/>
    <dbReference type="OMA" id="NYLPIHV"/>
    <dbReference type="OrthoDB" id="6408474at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000130">
        <property type="entry name" value="Spalt-like transcription factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003287">
        <property type="entry name" value="Zgc:113343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001465">
        <property type="entry name" value="Zinc finger protein 560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000290">
        <property type="entry name" value="Zinc finger protein 697 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF23">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022085281.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32415" checksum="35DC203208F9A7E2" modified="2022-01-19" version="1">PLTLINMNDQTTEKPFICDICGKDFSRNSNLQAHERTHTNEKPFVCEICGKAFSRKGSLQRHVIAVHENEKRFVCDICDRVFTCWNYLERHMSTHTKGKPFVCDICVKAFTYRRVFERHMRIHTKEKPFSCDICGKELSRKSSLQTHIRIHTKEKPFVCDVCGKAFSRNNYLTVHKRIHTKEKPYVCNFCGKAFANDGAHYVHVKIHTSEKQFICHICGKGFLRKGSLQDHEKVHIKEKPCARNTLKRNQQSPVMVAGYTCQVGQQMGSNIREVIYLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0Y2</accession>
    <name>A0A8B7Y0Y2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Scavenger receptor class B member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SR-BI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110976726</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Caveola</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CD36 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085950.1">
        <property type="nucleotide sequence ID" value="XM_022230258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0Y2"/>
    <dbReference type="GeneID" id="110976726"/>
    <dbReference type="KEGG" id="aplc:110976726"/>
    <dbReference type="OrthoDB" id="514335at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005044">
        <property type="term" value="F:scavenger receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005428">
        <property type="entry name" value="CD36/SCARB1/SNMP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002159">
        <property type="entry name" value="CD36_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923:SF110">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11923">
        <property type="entry name" value="SCAVENGER RECEPTOR CLASS B TYPE-1 SR-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01130">
        <property type="entry name" value="CD36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01610">
        <property type="entry name" value="CD36ANTIGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01609">
        <property type="entry name" value="CD36FAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022085950.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="60483" checksum="9BAE37BAC6C47231" modified="2022-01-19" version="1">MLTCPGMCVRVNTVLSKDRIALRSYTKSLVLSSNIHVEPCRARNSASTFSRARRPTVLIVVLGQMMVISPKSPIYPEWKDPTLPIYTKFYFLDLQNPQEVLEGGRPSVVEIGPYSYKMSLPRENVTFNDNGTVTSTQPYSYVFDRSQSVGDENDTFTTANMPFWSTVYFVRDAGLLIKAALSLFLASQKEEPFMRLSVRQLIWGYDEPLFKWLHENLPDYPLPPGFETQFGFLLGRNDTPLGLYTVFTGVGNKMKVNQIDKFNGMSHLTYWKSESANRITGSDGMMYHRGIEEDEVLNLFHPDLCRSMPYTYVKDDSLKGVPLKIFGVAPWAYQNSTTYPPNQGFNITPDEVPRGLMRIDPCRYGTPIALSNPHFFDGDPSLAGGIDGLSQNPEKHRNYFSIEPILGMPFKLRMRLQINQYMQQVQGISQTGKVKTMYMPGFWFEEDVTANDEVIGYYDTGIKLTGIIALLMQYLSIAIGASIIVAFLLVGFCKLITKEKKSIISEPIETNYDSTHVYDNINPVLTTQRNVQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2Q6</accession>
    <name>A0A8B7Y2Q6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Apoptosis-inducing factor 1, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110977206</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>A + NADH + H(+) = AH2 + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:11356"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086812.1">
        <property type="nucleotide sequence ID" value="XM_022231120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2Q6"/>
    <dbReference type="GeneID" id="110977206"/>
    <dbReference type="KEGG" id="aplc:110977206"/>
    <dbReference type="CTD" id="9131"/>
    <dbReference type="OMA" id="RSIFFEH"/>
    <dbReference type="OrthoDB" id="6029at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029324">
        <property type="entry name" value="AIF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF4">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14721">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01353">
        <property type="entry name" value="AIF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="2"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial apoptosis-inducing factor C-terminal" evidence="14">
        <location>
            <begin position="297"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022086812.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="48828" checksum="BC984A3591EC0C1C" modified="2022-01-19" version="1">MRPPLSKEFWFSKDRESIASLKFTQWNGKERSILFEPDSFYCDPTELSERENGGVAIFKGHKVVSLDVHKKAVILDDGKVVKYDKCLLATGGTPRNLPAFRKAGEEVKKRTTLFRNIKDFQKLDEISQEAKSIVIIGGGFLGSELACALGRRGKETGLKVTQVFPEKGNMGRVLPEYLSKWTTKKVKNEGVNVIPNVFLKSAGFDKSEEKVVVRLNDGQQLPADHVVLAVGLQPNVDLARESGLEIDDDLGGYRVNAELEARSDVFVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGGKKPYWHQSMFWSDLGPEVGYEAIGIVDASLPTVGVFAKATPKDTPKAVVEETGESVRSESESVAAATPPAPNMAKVAPVATEDYGKGVVFYLKNNMVVGVVLWNVFNKMPIARKVIKEGKEYSDLSDLAKLFNIHEVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2T6</accession>
    <name>A0A8B7Y2T6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tripartite motif-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110977105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086625.1">
        <property type="nucleotide sequence ID" value="XM_022230933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2T6"/>
    <dbReference type="GeneID" id="110977105"/>
    <dbReference type="KEGG" id="aplc:110977105"/>
    <dbReference type="OMA" id="CHDICRE"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000623">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086625.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36525" checksum="09EBFD03100678BA" modified="2022-01-19" version="1">MATMAKKGHISSLWKFAQQHLVCPICHDIYRSPKMLTCLHSFCEECLHMCYGSCQKELACPMCRIKVPIPQGGVQSLPTDFRLMSMVDSVQKEGDQTATPPSRVYCRTCDVPLCSGCLEESSEHNRHKTEAVTAGVVAEKRRAVTDHVLKYQARLKEILAALRTVDKLEQDFASVLLRTRKDIQHQAETEIAKVNVARAKLTAQLNQLQSNRKRLFGGYTRRLSSLRDIVQEFIDYAEDSVKACNDSDFLQRYPKLSTGFLFLSDINLPNIDTNSLVLKFNPSASSCLGSLLTESHGQLPTPAPKPRSLSTHSKNNVVQKTNSQIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3C6</accession>
    <name>A0A8B7Y3C6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="5">PME-1</shortName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC110977215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022086820.1">
        <property type="nucleotide sequence ID" value="XM_022231128.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086821.1">
        <property type="nucleotide sequence ID" value="XM_022231129.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086823.1">
        <property type="nucleotide sequence ID" value="XM_022231131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3C6"/>
    <dbReference type="GeneID" id="110977215"/>
    <dbReference type="KEGG" id="aplc:110977215"/>
    <dbReference type="CTD" id="51400"/>
    <dbReference type="OMA" id="VMVCHHG"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="79"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022086820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022086821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022086823.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="42908" checksum="71D4FD2796803DC6" modified="2022-01-19" version="1">MSELQRKAQMKGISSKLPPMPPKGPSSGSRSLSLRLGHPRKRDFSQLPWSDYFHSCQDVEVDKDNIFRVYRRGAEGPVVLFLHGGGLSSLSWAVLASLVTKSVRCQCLAMDFRGHGNTVTPNEHDLSASTLARDVGNVITALYGDENVPPIIMVGHSMGGAIAIHAAVQFLVPSLAGLIVIDVVEGTAMEALQGMQSFLRGRPKQFRSLEYAIEWAVKSGQIRNLESARVSMVGQLKRCSQECQTVSDQVPSCSASEAIAEEDEELENPKDASSPTQQQEEVSASTSVPYTWRVDLSKSETYWKGWFEGMSNLFLSCAVPKMLLIAGVDRLDKDLIVGQMQGKFWMQVLPQCGHCVHEDQPQKVADILASFLVRNKLAEAADEFVRPSPAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y496</accession>
    <name>A0A8B7Y496_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110977839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022088008.1">
        <property type="nucleotide sequence ID" value="XM_022232316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y496"/>
    <dbReference type="GeneID" id="110977839"/>
    <dbReference type="KEGG" id="aplc:110977839"/>
    <dbReference type="CTD" id="56922"/>
    <dbReference type="OMA" id="FINKPKH"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006367">
        <property type="entry name" value="PRK08591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="43"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="162"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="638"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022088008.1"/>
        </source>
    </evidence>
    <sequence length="712" mass="78217" checksum="02BB1DEDFE3C8D15" modified="2022-01-19" version="1">MATIMRASRLLLATEVFRQGRNTGRLSKSHSSCRQLSDVLPVPISKVLIANRGEIACRVIRSARKLGIKTVAVYSDADKHSMHVAMADEAYHIGPAASQLSYLNKQKILQVAKSCGAQAIHPGYGFLSENTEFADLCDKEGVIFVGPPSAAIRDMGIKSTSKSIMSAAGVPIIEGYHGVDQSDDRLRAEAEKIGYPVMLKAVRGGGGKGMRIVMTAADFDEALESARREALKSFDDDVMLVEKFVDTPRHVEVQVFGDKHGHYVYLFERDCSVQRRHQKIIEEAPAPGLSEEVRQSIGEAAVRAARAVNYVGAGTVEFIMDSKQNFYFMEMNTRLQVEHPVTEMVTNTDLVEWQLKVAAGSPLPVTQSDLCLHGHAFEARIYAEDPDNNFLPGAGPLVHLSPPTADQTIRIETGVRQGDEVTTFYDPMIAKLVVWSPDRETALEKLRSSLRDYHIVGLKTNIRFLDDLAKHPEFIQGNVHTGFIPQYEDQLFSRKGALNRLTLCQAAMALILFEQQKGQNEAVASGDPFSPFSMGSGIRVNENLIRRIAFTDKDDTIDATVTYQANDRYRVEIGDETFDVQGQLTQIEDNTAQLVGTINGIKTDTKVVMHEGAVHIFAEVGGVEVMRPIPEFLGGSGSGTMGDRAPMQGDITHIYAEPGTAVEKGDPLLALESMKMEYVIRAPKKGVIDEVLVAKGDNVQKNAPLVVYKGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4M7</accession>
    <name>A0A8B7Y4M7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110977564</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022087492.1">
        <property type="nucleotide sequence ID" value="XM_022231800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4M7"/>
    <dbReference type="GeneID" id="110977564"/>
    <dbReference type="KEGG" id="aplc:110977564"/>
    <dbReference type="OMA" id="MEFHRFY"/>
    <dbReference type="OrthoDB" id="336747at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14086">
        <property type="entry name" value="STKc_CaMKII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000009">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000001">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000002">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013543">
        <property type="entry name" value="Ca/CaM-dep_prot_kinase-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08332">
        <property type="entry name" value="CaMKII_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="34"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022087492.1"/>
        </source>
    </evidence>
    <sequence length="519" mass="59065" checksum="8555C283074E2441" modified="2022-01-19" version="1">MRAVKVQYKIHHSFSNMATTLHQQDVCTRFSDEYELKEELGKGAFSVVKRCIRKKTNQEFAAKIINTKKLSQRDLQKLEREARICRKLKHPNIVRLHDSIPEENFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVDHCHKNSVVHRDLKPENLLLASKAKGAAVKLADFGLAIELQGDQPAWFGFAGTPGYLSPEVLKKDPYGRPVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGSYDYPSPEWDTVTTEAKQLIDSMLTVNPAKRITACEALKHAWISNSEHVASGMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSLSHKNQSQGSPQTKSGESQEKAGGKTMMKKDNDIKESQESSVVEDDDVKARKLEIVKVTEALIDTINNGDFEGYTKLCDPHMTCFEPEAFGNLVEGMEFHRFYFDNVLSKNNRARNTTILHPHVHLIGEDAACIAYVRLTQYIDRNGLPVTAQSEETRVWQRRDNKWTNIHFHRSGSPSAPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y514</accession>
    <name>A0A8B7Y514_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977643</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087627.1">
        <property type="nucleotide sequence ID" value="XM_022231935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y514"/>
    <dbReference type="GeneID" id="110977643"/>
    <dbReference type="KEGG" id="aplc:110977643"/>
    <dbReference type="OMA" id="TMRESTI"/>
    <dbReference type="OrthoDB" id="10346138at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087627.1"/>
        </source>
    </evidence>
    <sequence length="131" mass="14572" checksum="8640D75E09B5A208" modified="2022-01-19" version="1">MATDFSGRWKSSRSEGWPELLDKLNIPKDKLPPDLRITQLISQTGNQINIKTTNNIDDTMRESTIVVGEKFVDRAAGHDIEYLTAWNDDGKLVLTRTNGNGGMTRELTAGGEMLVTHLHEGVVAKSFFAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y695</accession>
    <name>A0A8B7Y695_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein FAM198B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110977462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GASK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087326.1">
        <property type="nucleotide sequence ID" value="XM_022231634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y695"/>
    <dbReference type="GeneID" id="110977462"/>
    <dbReference type="KEGG" id="aplc:110977462"/>
    <dbReference type="OMA" id="PLMLYEP"/>
    <dbReference type="OrthoDB" id="10011371at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029207">
        <property type="entry name" value="FAM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15905:SF1">
        <property type="entry name" value="GOLGI-ASSOCIATED KINASE 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15905">
        <property type="entry name" value="GOLGI-ASSOCIATED KINASE 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15051">
        <property type="entry name" value="FAM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022087326.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="67432" checksum="079C0723CD4705D1" modified="2022-01-19" version="1">MNWEPVRSQHRSRWLRHLLRSWRRWLLLLVLTVFIATNSLLYRGLNRAGRSVDPRSLPVQERVISIDSWQTDLGDTGGGRSDLYIDSPGQFHRLSGSQRDRVDSRTGKNRAGVPMVRYIRRSDDANTGFDEKQLIDTHAKAERVKGVSRGGPAKRVAVRHDYRMEIGKKQKVRTGQNVEGTQQDTTPNETILLRRPKIPINLVHVQSADSQSKSYPFPNKVKTRASELTMSRTSYQSKWHVERINNPSVSAAKEDLETGKIRFYSRPTWLSEHDVKTLRRLANDPITEFQTFSVQHAGKFGLGLLVLESGDELRRTGHDSGRSNDSGTTVTAQLCDHSGVTCAVLFPPSEIHRVAAFHLDRVLGFNRTLPTVSRRLTEELRRQVGLPVDVSCPLMLYEPNLYLDQQLATLTRAELTDCLAGTDGTGGVEWCNNVLAENWGAVALFDFLLQIYHRLDFGCCGLEAAERMRRCGLVAVVGDIREAPRCTGISGDRSVDQQQKIGCNYRLSSEADRLVLAENLVDFLAPEDKVDMWILRGINSFPAQAVAMIREGRLRQSLLQSLFSDKGYWEGQGGRPAIEKILDVIDKRGRIFLKYIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6A9</accession>
    <name>A0A8B7Y6A9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mesoderm induction early response protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110977765</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087880.1">
        <property type="nucleotide sequence ID" value="XM_022232188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6A9"/>
    <dbReference type="GeneID" id="110977765"/>
    <dbReference type="KEGG" id="aplc:110977765"/>
    <dbReference type="OMA" id="PRRCKYL"/>
    <dbReference type="OrthoDB" id="5916873at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000025">
        <property type="entry name" value="Mesoderm induction early response 1, transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045787">
        <property type="entry name" value="MIER1/3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF28">
        <property type="entry name" value="ELM2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19426">
        <property type="entry name" value="MIER1_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01189">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ELM2" evidence="7">
        <location>
            <begin position="183"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="285"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022087880.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="62087" checksum="AA5B2388586F0538" modified="2022-01-19" version="1">MAEPATSDSSPETDQDFDVTAEMLVHEYDDERTIDEEESNEMGECFSNELDDLAEEAAIPVDQLWRMYAAPSPGTAPLAQQDDSTETDGSTDEILNSRNLTLDKEEIAQDLLPDGGGDAEEAAGEESIDDLHSDLFPGPGSHASDSPGSYGTHRLLRSNTATDGDSDSGSEDSDYVPPEDWKKTISVGADYQAVIPEGLSHYGDAPAYDNEDRLLWDPHQLAVDPVEDYLREVQRPPLGTTGVKSLPLGSHVRDDERSLYILLQCGHNVEEALRRHRMQIAPPMDEMSLWSEEECRNFESGLRTYGKNFHLIQQNKVRTRSVGELVQFYYLWKKTARHDSFANQARLTKKKYHLHPGITDYMDRFLDDAESLVSPIPSHSLLDKHRLNNKLAQPTSMLATLNGASPAELLSNGSPEVGGLVMGDLPNEMSATGAAAAGLDESLKRSADFPDSNGPTKHRRVEPEVDHSGQQQALQELGLLMEPDLELNNSVHSRDSVVSADSARQAPCPPQSAPLPSTQVPPPPSPLVKPLRGSLTVVPPSHSVASDSVLNVRPLVTSNMQAPNPVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y779</accession>
    <name>A0A8B7Y779_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1</fullName>
            <ecNumber evidence="2 8">2.1.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cap1 2'O-ribose methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110977650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).</text>
    </comment>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="2 8"/>
    <dbReference type="RefSeq" id="XP_022087636.1">
        <property type="nucleotide sequence ID" value="XM_022231944.1"/>
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    <dbReference type="GeneID" id="110977650"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:mRNA modification"/>
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        <property type="entry name" value="FtsJ-like methyltransferase"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
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        <property type="entry name" value="G_patch_dom"/>
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        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
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        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
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        <property type="entry name" value="RrmJ-type_MeTrfase"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="WW_dom"/>
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    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
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        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PATCH"/>
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        <property type="entry name" value="SAM_MT_RRMJ"/>
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        <property type="entry name" value="WW_DOMAIN_1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RrmJ-type SAM-dependent 2'-O-MTase" evidence="11">
        <location>
            <begin position="310"/>
            <end position="527"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="34"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="55"/>
            <end position="66"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="99"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
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    </evidence>
    <sequence length="915" mass="104872" checksum="B887DBC8401530B7" modified="2022-01-19" version="1">MYKYKANKRGSSQLPPKKKLKVELEPPVAVVDHVDRRDAFDFTDSSSDDERPPSFSLNRRASSNEAISPRPAPGQGQSSPRVDSPSGMGSQLASPTYYSDFSDFRESLSPPEARPRTSHGNSGGRFFQSECHSSTEDSASEKEALLSFSPPSWQQDTAKDGSYMYSDKAQKMMASMGYRKGEGLGVGGKGRVDIVESSKQRGRRGLGHVTEGFEASDDLVWDETEEVSAHETYKWMPPCNPIDEAELVQWRDWKREKRKDYIDDETHFCDPAILRKLLAAKSAFDKLDDPEEMRHARTRSNPFETIRGGIFLNRAAMKMANMDYVFNFMFTSPRDGHERPLVGHNDLLYFCDICAGPGGFSEYALWRRKHRTKGFGFTIKGPNDFKLEEFFAASPEYFEPHYGVNGAAGDGDIMRSDNQVEFRKFVYENTDNKGVHFVMGDGGFSVAGQENIQEVLSKQLLLCQFLVALSVLRPGGSFVCKTFDLFTPFSVGLIYLLYRAFYRVSLFKPVTSRPANSERYIICKGMRAGANLIHDYLFDLNRVMNQLRHSSDDIMEVVPLDVIKADVQFTQYITDQNERQAQSQAQSLAKIQAFVRNTNLLEPKQAAMREECLRLWGIPGDTRSTPKLPDPMTKFNQLNKDDSSEYFHQSPTVLDRESLGRSIRSIFDYRCMVSGGDRVFIIGIGRSHVFQWNGRPTSKWTKLQMCNLRLPGDTLFEAEIVEELRGEGYGQRRSYALHMLDAMWLGGEDVRQLHFTERISKAELFVKAIHKPTKPDLTPLRVKEVFRFEEIHKIFDRLEFKQVKGSGRHQRLCFRTNTDRHFIPTGVCLVKTTNDPWTMHWSRTNQRKYFHNASTRESTFDCPPDCIASFKACHLNRLQWVWEEGVQIHERQMQYDQEKLSKDDVLDLVNRQRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7P3</accession>
    <name>A0A8B7Y7P3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dedicator of cytokinesis protein 7-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110977731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_022232094.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="aplc:110977731"/>
    <dbReference type="CTD" id="85440"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2_Dock-C"/>
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        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
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        <property type="entry name" value="DOCKER_dom"/>
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        <property type="entry name" value="DOCKER_Lobe_A"/>
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        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF76">
        <property type="entry name" value="LD20667P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="5">
        <location>
            <begin position="619"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="6">
        <location>
            <begin position="1723"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="441"/>
            <end position="503"/>
        </location>
    </feature>
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        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1457"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2155"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="972"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="2165"/>
            <end position="2174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022087786.1"/>
        </source>
    </evidence>
    <sequence length="2187" mass="247561" checksum="8CAE7BB8E03090E0" modified="2022-01-19" version="1">MAASGGGKGQRAFAQKLNKNQPAADIRRQVSSHYSGRDLARLGIGTAATGTVPLSEVVDPLDFEEFLEANRAPYNRDPLRHLLEFPDDDLLVTSKTKECRTVNQPLPEPDSDSNIQVRDCLQTYTCDWAVVLRRYQDCVAVDPNKKDTQRSVVEGACQQVFEVDEQELEEDIPQFTFDEDMGFEIMSPDIWKSLLPSRFNLPKKRPGKRSSIHLDNTPRGSWASSIFDLKNTESDALLPRLLEHTPIDRQDSINEDVRAHNRQRDIFCLYPVVEESEAIERRMPADVPREHFGYRIFVKCLTLKLDLEVEPIFASMALYDVREKKKISENFFFDLNTEAMKTMIKSHLGYPDPSTLARNAIFSITYPTNDVYLVIKLEKVLQQGDISESAEPYMKELDNPKHIEKAKANARYYCEKLGAYRMPFAWTAVHLLNIINGANSIDPNPESADMDRAKSNSLDFNRKKSVPADQNYGSLPRKGGEVGPSSGPSGGGGGASLKRNGSERRSFYKVEDETGNLESFHPVTITVSSFFKQEGDKLSDDDLYKFLADLKRPTSVLKRLKCIPGSLKLDISPMPENPPYCLTPDLQQVKPYPDMRTRPTREIQEFPSRDVYHPHSIYRNLLYVYPNSLNYSNRSGSARNIAVKVQFMAGEDPSTALKCILGKSSCPEFSDHAYTSVTYHNKSPDFYEEVKIKLPADLADYHHLLFTFYHISCQRKQDVTPVETPIGYTWFPMMRDGRLQVGDFSLPVSMDVPPMGYSMLSPELLKSRALSKADSTRTPQVQLPTMRWVDGHKPLFTVEIKAVSSIHAQDEYVDKFLSRCHNVEEGKIPRSIGEQDMKAKLVKSIMELNNAVAEPLVKFLPIILDKLILMIVRPPIIGGQIVDHVGQLCFDTIAEIVDRIHILLDKGQDSHGRNSLLCSFIQFYFRPPDTDDETIVQDISPQTPPYKFRLLGNYGTVARSNSFTVNQRSSLFSSTSSSSLSGPGSPDDELEGMIHGRFGSERYNAHSFSRSSLLGNTGMGNVPVMGLGNRVPPKKLVHEEIALLLVVSNGSAKEKVLNHAWFFFELMVKSMAQFLAENDRLDSPRKTRFPEAYCQDISNIVTIVTTDIVARYNKDVRAMQLLNASLAFFLQDLLSLMDRGYVFALIRNYCREVANKITVMTDPTSLAQLKLEFLRIIVSHEHYVTLNLPFLQSDVTSRPPSPTPSISSMSSMMSLASSLPTIINKSKMMQLTPEFRQQHFLTGLLLSDLACVLQTLNSSLHRQAIDTVFNLLSSHDADKRYLDADCRMRVAALYLPLLGIVMDAIPQLNCPSASSTNRPSAAMGYDDAELDGYPVNQSVAMAIAGTSVYARSDAKVESTPLQRPPSHTRLSEESTKDLLLCVLWVLKNLDPCTLHNSWVDLSVSRINKLLDVLYYCICCFEYKGRKMIYRRQSRLSLKKQDVKQRLEDAILGTSNARSEMMQRHSRQGSGSLDRHFNPALGQSEKLRWRKDKTHWKQAVETQSERPKSELEHDANLEGHLSTEVSLVVLDTIELLVQSIQNTDHLQGCLTGVMEVLLHSLACNQSVIVLQNILATQRSLVFKYPELLFEEETEQCADLCLRLLSHCSSCISTVRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTQTNFNEEYLRRSLKTILIYGEEDIELQETDFPKQVRDLVFNLHMILSDTVKMKEFNEDPEMLVDLMYRIAKGYQTSPDLRLTWLQNMAGKHTEHKNHTEAAHCLVHSAALVAEYLHMLEDRPYLPIGCVTFEKISCNVLEESAVSDDVVSPDEEGICTGKYFTESGLVGLLEHAAASFNLAGMFEAVNEVYKILIPIHEANRDYKKLAIIHGKLQEAFNKIVHLGGKRLWGTFFRVGFYGSKFGDVDGEEFIYKEPAITKLPEIAHRLESFYGDRFGAENVEVIKDSNPVDQTKQDPEKAYIQVTYVEPYFDFYETLQRPTFFDRNYNIRRFMFATPFTKSGKAHGDIREQYKRKTVLTTAKAFPYIKTRVAVVHRQEIVLSPVEVGIEDLQKKTKELTVATHQEPPDAKMLQMVLQGCIGTTVNQGPMEVALAFLSDNTDGKQLDKHTNKLRLCFKEFSKKCGDALRKNKNLIALDQREYQKELERNYHRFTDRLMPLISNPGRVGGGTLRKSGRKDRRSKGSMTKIIKTSETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9I2</accession>
    <name>A0A8B7Y9I2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110978378</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022089020.1">
        <property type="nucleotide sequence ID" value="XM_022233328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9I2"/>
    <dbReference type="GeneID" id="110978378"/>
    <dbReference type="KEGG" id="aplc:110978378"/>
    <dbReference type="OMA" id="KDIGHHS"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF583">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034136649" description="receptor protein-tyrosine kinase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="536"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="917"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022089020.1"/>
        </source>
    </evidence>
    <sequence length="969" mass="110406" checksum="C1460C090D28DE1E" modified="2022-01-19" version="1">MVLLVWFIIVLPLHCETRRAPSEYPHSAESQAEHPFGRDTSPLDPFRADVLCRARCLAKCLSNNNTVARGGECTHICDYFNSTWLTEICKTVDCWASCDNLTRGSDSLLEKPVLGKPQLADNHLSLRWHRANCTTCHHWDQELVSIIRYRAHHDEWSYEIQTENQTFVMDLEDVCAKFFQIALVSEFGASPSSDMKMLEPIPVIKDSSLTARANRRLFSFKLRLSWETVSGWIPNVHFYLVTLTHPRCKRQPTNAQIMNNSSRLRIRNGEVNLDNEDLDLARGDCEVTYEVHGTFGACYNIQPVKFKYRYVCQEIFRDDSQNCLRQGSSPRLQLTSVSAIRYPHNKSAMVQWHAVDPSPNVNGYIVQWGKVIRNDNSSNQLLPILNLYPETITDISIPGVKNNYVWLTGLEADILYGVRVAINITGAETNLATVPTYSFEISLEAVNSSYSTPLPDEQPTLTIILIVASSLLCVFALCMMLAVVWRCRLRQMESRMSKTRLRRDEESMPNVYTITPSADNPDPPIPDRWEIPFDRLEMGEMLGKGQFGIVMKAFIPGKLSTHYTSGSSLFRDSIKRYDVQVAVKMLHGDADEWQRQEFRHEMKLMKDIGHHSNLVSLLGCCSTDATPLCLIVEHCCHGDLLQYLRAKRGPMERLDHFRMAEKADGTESDPLMPKDLLSFARQIARGMEYLSQKGFVHRDLAARNVMVAEDKTVKIGDFGLTRYVYDDKIYVHRRGGKLPIKWMSVEALNDQVFTTYNDVWSFGVLLFEIVTLGASPYPGIQNEDILGMLKGGYRIVRPENCSEVLYAIMIACWHHFPEDRPTFTDLRHKLEALLEEDTPYLDFCQNYKHYPFFEISEEWDSEEEQEEVGDKGSDTTMSSRARPEVIPMVSIESSEDDVTVLASTPEEVFVELEPMLGTDEGDDASGSLSQIKDTGGQLQKRDSGLGSDYVYSSHNTNMEDIPLIKQFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAZ9</accession>
    <name>A0A8B7YAZ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110978295 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110978295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088881.1">
        <property type="nucleotide sequence ID" value="XM_022233189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAZ9"/>
    <dbReference type="GeneID" id="110978295"/>
    <dbReference type="KEGG" id="aplc:110978295"/>
    <dbReference type="OMA" id="YYECICA"/>
    <dbReference type="OrthoDB" id="9937281at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050906">
        <property type="entry name" value="Notch_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044">
        <property type="entry name" value="NOTCH LIGAND FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044:SF417">
        <property type="entry name" value="WEARY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="4">
        <location>
            <begin position="70"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="225"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="268"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="6">
        <location>
            <begin position="310"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022088881.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="55592" checksum="1FB450825383FF6F" modified="2022-01-19" version="1">MSTSGDYRKVTLMMENPSYDGLADGRSRRRPHHRMKPFILVILLLLAVVGVAVALAVILTGNKTNLDVPEEVTILGSLHISNREYRESYGDRSTKEFASLEREVVDAMDRLYNKSLFRNIYVGTSVTEIRKGSVVVDFAIHLEIPKTLFDLKQDEHKKVSAPEYNEAYVHLVKAIDDNTLGEFTIIEFSLSFDSKSLSFQAITLPPVSKTVGQADQGEPTLSPLPTDACNDNPCVNGGTCVLQPETALYFTCKCPEGHSGYLCQNIAPSNPCNSNPCQHGGQCWFGTIDGQDRYTCICPPGYDGQNCGNPKQTQCIDIPIPQCCPFLPYNQTVSPNPFKLTETHEELLEFFELSYHFLTPTCHPDAQRVLCTILNPQCPQLRTAGHAAGDEQASVLDFQLPCRSVAGRFMTRAWPTSLHSSVESSRSSAISVIPCRSLQRTVFVSALPVKKRLTVGLSGACPHRVRTEVLAWNSTALPGVDVRRATVDKRVLLSCPILAHPAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDA4</accession>
    <name>A0A8B7YDA4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110979235</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090542.1">
        <property type="nucleotide sequence ID" value="XM_022234850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDA4"/>
    <dbReference type="GeneID" id="110979235"/>
    <dbReference type="KEGG" id="aplc:110979235"/>
    <dbReference type="OMA" id="TINLIMQ"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="118"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090542.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="38638" checksum="E859FB56AF56298F" modified="2022-01-19" version="1">MAAAELDLAPLYTPATDEREGRYIVALKAGSQDVDDFLGNLVTNDGITVTMKYRDAAFRGFAAGMTDDALQMIRKNPEVAFVEQDSIVRADWVASWGLDRVDQRKLPLDGKAEFEGTGKGVNAYIIDTGIFPDNKFFSDRAYVAYDNVGDGKKGIDCNGHGTHCAGTIGGEVFGIAREASLYGVRVLDCFGSGFTSNILDGMDFVAKNAQHPAVASMSLRSPQSEAMEEAVRRLVEADVTVSVSAGNSDGDACNQSPASAKEAITVGATDIEDQRASFSNYGKCVDLFAPGVDIPSLWMGGDFAVNTISGTSMSCPHVSGAAVITRGNDPTSTAPEVKAKILKDATPNVVKNPGPESPNLLLYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDH9</accession>
    <name>A0A8B7YDH9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vam6/Vps39-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091314.1">
        <property type="nucleotide sequence ID" value="XM_022235622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDH9"/>
    <dbReference type="GeneID" id="110979632"/>
    <dbReference type="KEGG" id="aplc:110979632"/>
    <dbReference type="CTD" id="23339"/>
    <dbReference type="OMA" id="EEYCNQV"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="15"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="565"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022091314.1"/>
        </source>
    </evidence>
    <sequence length="880" mass="100784" checksum="AA425A17EDB14F15" modified="2022-01-19" version="1">MHDAYEERPILEKLPLQIESIACHGDQLLVGTKQGHLLVYSVTAGIGNLSFKVDLLKSFKSFSKRPIQQLACIPELQILISLSDAVINVHDLNHFSQITSIAKTKGATLFAIDLQKLTTESGSSTYNLRLCVAVKRKLQLFYWKNRSFEDVKAELGVPDVPKAMAWCGSSLCVGFKRDYFLIRVDNGELKDLFTTGNATQAEPTVTRLSEDMLALGRDMMSIIIDSEGQPAKKYALTWSDFPIVLEHDQPYIIAVLPKYVEIRTVDPRLLVQTIELNKPRSITIGSGHVYVASQHYIWRLVPIPITTQIKALLADKQFELALHLANMTDEVEADKQRRIQHIQNLYAFELFQQHRFEESMKMFSKLGTDPSQVIGLFPDLLPKEYRSKLEYPSNPTELTGQAMEKGLTALIEYLTQKRQDLMKASGKELNQPSTIVEGCATVTSRKQMSLIIDTTLLKCYLQTNDALVAPLLRLKDNNCHLEESERVLKKHQKYGELIILYEKRGLHRKALDLLLRQSQKPNSPLKGHERTVAYLQRLGHEHMDTICEYAKWVLKAHPEDGLKIFTEDIPEVESLPRIRVLDYLMTVVKRLTVPYLEHVILTCGDTTPEFHNRLIHLYREMVQEKMADYLHTLPEGQLPPRAGTEPGEFGELRRKLLFFLETSSSYIPERLLTHFPFDGFYEERALLLGRLGRHEQALAIYAHVLKDTRRAEEYCRRNYARDPQTNKDVYLSLFKTYIKPPDASSLRIMASIEPSKPNIKAALEVLQFHHDKVDTARALEMLPETIQVSDVCGFLEGVLETKAKHRRNNQILKSLFFSENLQVREQHIHYQSQKCVITEERNCPVCKKRMGNSAFARYPNGVVVHYYCAKDRSVCPVEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDQ4</accession>
    <name>A0A8B7YDQ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proton-coupled folate transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090697.1">
        <property type="nucleotide sequence ID" value="XM_022235005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDQ4"/>
    <dbReference type="GeneID" id="110979312"/>
    <dbReference type="KEGG" id="aplc:110979312"/>
    <dbReference type="OMA" id="WIALEPC"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="23"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022090697.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="60035" checksum="14F566909123E920" modified="2022-01-19" version="1">MGKTSDAIHALKESLRILTVEPIVFVLSMTNFMRTPSSQLLVLHKVCLLSYNDTICSDGGDTAIENDVQADAAYWNFYLKLALFIPGAVVSSLYGPLSDRLGRRMFLIMPSLGNILGAASFLLQTYFPKMPLDYLIASEVAVGLSGNIVTSYIVAKSYLCDVTDSSNRTKRLGVMKALSHVGGPIGAFLFGVLVDQSGFAAIYFILVVIHGFVILYVIFWLQETVYSESDQEMSSGDDEDEVDETDAEDDSVQEDRETETDGHTKLKNGENIKNAKNEQVESDDSKEDEHGCNETRRSIRQSLTEVWKGVRSMLLLCFRERQGSSRKYLLLAMLIGIIHNVCSSAESDLIVFYTKHSPLNWTATTIGIFIALRTALKAVTLALGVPLIFKVVKNHTMQLDLGLACVGILSISVALTMTAFAQSTSVMMIAAVVGMLVSFPSVAITAFKSKLVDPHEYGSLFAVTALIQTLMSVASSGLFNNLYTVFLPVWPGLSFIVIVGFYALSLLIILYIWCDINSKSQEEDMMTDCGPTYKALKNIEDGKTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE96</accession>
    <name>A0A8B7YE96_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphorylase b kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110979811</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan biosynthesis; glycogen metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cell membrane</location>
            <topology evidence="2 13">Lipid-anchor</topology>
            <orientation evidence="2 13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the phosphorylase b kinase regulatory chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091578.1">
        <property type="nucleotide sequence ID" value="XM_022235886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979811"/>
    <dbReference type="KEGG" id="aplc:110979811"/>
    <dbReference type="OrthoDB" id="5971574at2759"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005964">
        <property type="term" value="C:phosphorylase kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000004">
        <property type="entry name" value="Phosphorylase b kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045583">
        <property type="entry name" value="KPBA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008734">
        <property type="entry name" value="PHK_A/B_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10749:SF7">
        <property type="entry name" value="PHOSPHORYLASE B KINASE REGULATORY SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19292">
        <property type="entry name" value="KPBB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="11 13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH15-like" evidence="15">
        <location>
            <begin position="8"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylase b kinase regulatory subunit alpha/beta C-terminal" evidence="16">
        <location>
            <begin position="995"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1207"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1210"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF19292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022091578.1"/>
        </source>
    </evidence>
    <sequence length="1339" mass="151208" checksum="DB742ECFF953977B" modified="2022-01-19" version="1">MRSRSNSGVRLDYYHRLVTKTIISHQHPVTGLLPASTVLKDAWVRDNVYSVISVWGLALAYRKQADLDEDRAKAYELEQHVVKLMRGLLVSMMKQVEKVEAFKKTQSRKDCLHAKYDIQTGDTCVGDHEWGHLQIDATSLYLLMLAQMTASGLQIIFSLDEVAFIQNLVFYIEHAYRIPDYGIWERGDKTNHGFPELNASSIGMAKAAMEALNELDLFGARGGPASVIHVQSDMIAKCQAVLYSMLPRESNSKEIDAGLLGIIGFPAFAVDDEALANTTRQQIIDKLQGRYGCCRFLRDGYKTALEDPNRLYYDPAELKVFENIECEWPLFWAYLLIEGVFKGNKEQADEYAEGLRETLVLLSDSTKVVPELYYVPKDKVALEYKNPHSQDRLPGGKIPHIWGQSFYILGLLLQEGFVAPGEVDPLNRRMSMEPKPDLVIQVSLVAEDKLIKELMKKHNFDIQTIEEVSPVRIYPARVLTRLCKRLGENKKLGLSGKVSKENGLLTTSKLYNVRGEILAFVPQFMDQQQFYLALDNDLLSDICKTDVAYLRHNWREIGRPTITFIITQTMMGLRKRKKKVTNPPNNEQVGEEPQPEETQWELYPAGEHGMLGSAMWAVIRKIKTGYLNGVQVKMGQLHEFLSTSCIKHLSFLETMDQEQDMPIDQYLESQLQQTCPVPFLPPVVEAKEGQTPLTSQSSEEHVAGISKTRKMSVTGIVQRTRSIDLGAGQMGSRSSSRGLFRQEEVQELPSIIEQDQENVPSPSSEQESLTWFEAVKSPSKLSRKPSFHLLPEDFADFPMKRTASWSEDKMVVDMYKGLNSKDLLAQLSESMSLSDQADILHFLYVEEGLDWDTKLSQRVDQKVTVKTLMEELYYKSAHYKAWSVVRHTAGILEKKVENLAQAVTELLVRQKQVSVGIPPEPREKIIVAPLPPKKLHRVISEACGEDKSSAVLTQELLVYLSMFIRTEPKLFYEMLRIRVGLIMQVMTSELARTMGCQGDKAYEHLMSLSPYEMKDLLHHILSGKEFGVAAASSKSVGIGERQLSIVSAQKDEIMGLSQIKRQLTSKSMSLRDVELEEDVFQEKVGQWLRRRRLDGALNRAPPEFYYKVWKILEKCHGLSIEGYSLPHHMTREMTENEFKFALQVETALNRIPQPEFRQLVVEALMVLSLVVENDWLSNLGAIIQVEGLVIEANEIFLRDQRRKRLRTKSMDASAQTNLKPTFPSSEGLQRAEAKGTSLGPDAQSSAAPSSRLRRSRSSSVGFEMQEMEVKGDATLCCAVDQPRPTPLACGGVAGICCHFYDSAPSGIYGTMAYLAKAGAKKLSFHHQFDENAEVDCRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEJ4</accession>
    <name>A0A8B7YEJ4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC110979380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022090820.1">
        <property type="nucleotide sequence ID" value="XM_022235128.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090821.1">
        <property type="nucleotide sequence ID" value="XM_022235129.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090822.1">
        <property type="nucleotide sequence ID" value="XM_022235130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEJ4"/>
    <dbReference type="GeneID" id="110979380"/>
    <dbReference type="KEGG" id="aplc:110979380"/>
    <dbReference type="OMA" id="HTTCPDY"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022090820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022090821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022090822.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43437" checksum="D08F10E377245D72" modified="2022-01-19" version="1">MDSAECVTLVPFVHQVGGHTGMMKYDEVTVCKPVSPAELRFYETLTPELAQFTPGFKGVVHVSVQEEDDGSLSVRAYPIRVQHQTLAGPRCPSNGELWAPDPAGEEDTERSPKSDEQKMSQTSLPEESDPLDNKDSSSEEDLFEDHSESKTTRQQFERGNPWGVHLNRLQMARMHKDFGSSKLHKFILLENLTSKFRSPCILDIKLGTKTYHKDHSEAKRQLHIDRDAATTTATLGLRLCGMQVYQPSKGCYKCRNKYDGRRLGKDGLRRALCEYFSTCDQVRMELLPPFIEKLQGLIRVVSAITTFSFLSTSLLFMYEGDTGDQSGVGASEVSRDLLVDLRIIDFANSESDPDHITDIESSNKGCLYGLKNLLQILESIQGTVNDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHV7</accession>
    <name>A0A8B7YHV7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Neuropeptide CCHamide-1 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110979577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091206.1">
        <property type="nucleotide sequence ID" value="XM_022235514.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091207.1">
        <property type="nucleotide sequence ID" value="XM_022235515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHV7"/>
    <dbReference type="GeneID" id="110979577"/>
    <dbReference type="KEGG" id="aplc:110979577"/>
    <dbReference type="OrthoDB" id="8888529at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF26">
        <property type="entry name" value="NEUROPEPTIDE CCHAMIDE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="37"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022091206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022091207.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34442" checksum="AFEAECA53E75722B" modified="2022-01-19" version="1">MADDLAAGTTAVSYQSEYVSPSVPALLSLLGSLGFVGNVCMVHAIAAHRKMRTVPNLLILNIAVACQVYLLLPVPFYVGRLFNSLWDVPNGLCKFEAYLAAVAGYVSVFALTVLSWDRHEVLSLPKEARHKETSYAMASSQAMAMWLGAAVLALPSLVFGKVDFIAGVCRFSTKPDETSIKQGFEILRFLIGYAFPLIIMASYYLKIAVNVYCGTDAKRFPDPSDATVSLVRDRERLTVTALIVSVFFTVCWLPYFSYFMLLAYFAQWSQALRDAALIMPIVNMCLTSWLVFAVSSRHRECLCSGWRSSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJL7</accession>
    <name>A0A8B7YJL7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondria-eating protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatogenesis-associated protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110980442</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MIEAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092817.1">
        <property type="nucleotide sequence ID" value="XM_022237125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJL7"/>
    <dbReference type="GeneID" id="110980442"/>
    <dbReference type="KEGG" id="aplc:110980442"/>
    <dbReference type="CTD" id="132671"/>
    <dbReference type="OMA" id="DQNLNIC"/>
    <dbReference type="OrthoDB" id="5966837at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035694">
        <property type="term" value="P:mitochondrial protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035695">
        <property type="term" value="P:mitophagy by internal vacuole formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026169">
        <property type="entry name" value="MIEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031981">
        <property type="entry name" value="MIEAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771:SF0">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21771">
        <property type="entry name" value="MITOCHONDRIA-EATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16026">
        <property type="entry name" value="MIEAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondria-eating protein C-terminal" evidence="15">
        <location>
            <begin position="246"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="441"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022092817.1"/>
        </source>
    </evidence>
    <sequence length="500" mass="56286" checksum="CAD11D291F8ED519" modified="2022-01-19" version="1">MAESLRRLVKTGGFNTLQDKLDLWSSNYLVNTCDQNVSRCCELIELTSRLQGQLFLILNLSAAEGGIYGGCDALKNRLLPWLTQGFTSSNATTDLSLDMMADVAAKDRALSKMRNDYEAQLQDLEEDLNTSRNVSDSLKQELQEAKSKLDEERSASVGEAILNEEDTIRLSTTIKALKDELEIYRSRVGVLENYEVEARRLREDVNLLREEKAILTGRMDYLTSPLPPTSPRTTSSVSSDVVQRVRQAHLVTRFGDMFSRDRMDAMDILRTLSDDHDIHQQIVFACVEEAFHCAKKAYRLYRSKVRSTLQLTHTGPETLEEAVQNYINKNGQLLDVHSIVQDVLLAMNTHPVLSYPPEVDFKSLSLFIRELVKVAWDMSALPNPLDILPARRGELFDDFKYRRSYDSEYSAPLVSHYVWPALQEVLTGKILLKGEAVTRRGATLASPRRSRSPNRAVTPRSGRSPSPRRIMDRSLSPAGSRPGSSLSPRPMSASSSFSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK04</accession>
    <name>A0A8B7YK04_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MKL/myocardin-like protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110980865</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022093588.1">
        <property type="nucleotide sequence ID" value="XM_022237896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK04"/>
    <dbReference type="GeneID" id="110980865"/>
    <dbReference type="KEGG" id="aplc:110980865"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051145">
        <property type="term" value="P:smooth muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="RPEL" evidence="7">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="10">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="380"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="677"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="735"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="393"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="679"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093588.1"/>
        </source>
    </evidence>
    <sequence length="1061" mass="114295" checksum="A1F1C05ABEA5C511" modified="2022-01-19" version="1">MSLLARAFAIAFSPSMVTGPAAYMTKKQKQKRSKKSKKSKELEKQDKKLLALRLKLRRPREELVSQGIMPPLKASPGFHEQRQRLERAKVGDSLQRKIRLRPEKSHLVNQHILADTNVDPLVNATQQRLKRSRLEQDLDTKIKNRPGPLELIEGNILKTDNALVEQAVKDGKVKFLKTNSLDSNPFEFEEDSQEGFSDEALSPSQSEVSQAESQLSTGSLPSAHSSSAFGDNSKTLQAQQQQLQQQQQHQASVSSPSQLVSPKAGQAFITIKQEPGLISPPPVTSNSFTPISAVSNISLASGGKVTPSPRQPRKKQTKRPKPKEIKFHEYKPPNEQSSKVQQASTVNNPYNLLLMQQQLYLQLQLLQQQQLILPNTANQKHTTTSASSSNTPVTSAHTSSNSTVTTTAAPAAAPAAPAQAAPVTVKQQQPDTKPSIAASQGKPRSLSNLEDMKVSELKLELKNRGLHVSGTKPQLVERLRPYMEQQVTTSASSPNEVSTTSVTSSTRVSSSTDLDVPFSETTSSAQGSLSTPPISPEFRSSLSVTSEPMSPGSAFDPMSPPTFQGTLTAAVCSPDTVSTTNQQTMSGSGQEGSPFDPTMPTLESPQPLPPASSILPVDMSGNDNSNQDMMDLSSLETTTSSGGQISSDILRQQQLKIQELERMLKLSQMQLQMQKLQQPNLSTVSTQQQQSPAGKPGTLSPHQLQQDSKPSAFMFHSKDFAHTLNQQPKVFSFASPPPNGQPFLFSKQQSPDNQSMSLPNGMVVPKAASLPSSPTERNVLGIGSGMTRSITQPTFANPPPNYEEAVRQVKERKSQGNSPVSGSPVGSPPKGNSANIDPRSTKSQDLDDLLEVLVDHGYQIPITPKFRDMQRTLHNSNVGATTVTHSVVRGRGGSIDLKLPVPGPSPPPPVTHSYPTSDLPMEVDPTDLNMSSLDLGDAGGGLTGGERTCRTQSVPFDIPMTTIDGCSETTMDTGKDAVGSASGVVHPDGDLNWLDLVIPSSATGLTPVSATPPTFNMDGAFGATLGKDPFPLNLLDLNDISTPTDLHHLEDDAWDNIPITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKD3</accession>
    <name>A0A8B7YKD3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-arrestin-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110980951</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093728.1">
        <property type="nucleotide sequence ID" value="XM_022238036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKD3"/>
    <dbReference type="GeneID" id="110980951"/>
    <dbReference type="KEGG" id="aplc:110980951"/>
    <dbReference type="OrthoDB" id="298939at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002031">
        <property type="term" value="P:G protein-coupled receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.840:FF:000003">
        <property type="entry name" value="Kurtz arrestin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000698">
        <property type="entry name" value="Arrestin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017864">
        <property type="entry name" value="Arrestin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014753">
        <property type="entry name" value="Arrestin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792">
        <property type="entry name" value="ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11792:SF17">
        <property type="entry name" value="KURTZ ARRESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00309">
        <property type="entry name" value="ARRESTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00295">
        <property type="entry name" value="ARRESTINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="265"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093728.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="59368" checksum="4B5FEBC3BD06B2E3" modified="2022-01-19" version="1">MYMPPGVSPFIVTPDRQPFADWILEIWDFCGPLLKFHFWKFVPHISVFARSLIFLTTMGDSSSQGADKKSHTGGDRVFKKSCPNGKITTYLGKRDFLDHMIQIDPIDGVVLVDTEYVKNRKVFVHVLAAFRYGREDLDVLGLTFRKDLYLASMQVYPPIPEEQKPLTRLQERLIKKLGSNAYPFLFQLPENSPASVTLQPSPEDREGKPCGVDYELRTYVGDSIDEKPHKRNSVNLAIRKVTYANPEMPIAQPSEEVTKTFIMSTNSPLHLEASLDKGMYFHGEKIAVNIQITNNSKREVKKIKILVKQYADICLFNKANYKCCVAYFETDKASDGLPVLPSHTLSKVFYVTPLLANNKHKRGLALDGKLKHEDTNLATSTMFKPCEKGREDAENIHGIVVQYKVKCSLDVPFSRPLSVLLPFILTHPKPEQPAESFPAPPNPEQRQQKEEALEAQQEALDTNLINFDTKNDPNRRAGKYCVGQTYMPGMLNPSGVEPATPQDDDLIFEDFARLRLQGAEGEGTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YM68</accession>
    <name>A0A8B7YM68_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110981257</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110981257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094363.1">
        <property type="nucleotide sequence ID" value="XM_022238671.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981257"/>
    <dbReference type="KEGG" id="aplc:110981257"/>
    <dbReference type="OMA" id="PKWPEWY"/>
    <dbReference type="OrthoDB" id="10498281at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034143840" evidence="8">
        <location>
            <begin position="30"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="9">
        <location>
            <begin position="230"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022094363.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="79764" checksum="57FA634A2C8D931B" modified="2022-01-19" version="1">MTQRANSGRSATCLLLVGLLGALFWNGQGKSCSSKLDCQPEVSCHLVPWSCNSSDDTESTTTASPTTNPLNTRCCVHLGTCGGEVEVAGWVNVRNTSIELDGVSYSAEWLDTFITEGNATLPSVIKTAYVGSWSTLKQADLTFPSQMFVAEPTNSCTVDGDPKWPEWYHVTVNVVDKDNPDDTLDIENERTKDCLCDVEWDCRDNMCWVETQNMSFGGANLSKTNPDLEEKVAKFCRSSDNVTIANYTTSSSFATGFGPEQSQIDSFNFNTSVEGGWAPDLDDTDIWIQVDLAEDTIISGIVTQGVAVNPERRVDEFKIEYEASDAAAEILGGDMIFKAGARLDTKMTNSFPQPIKANRVKILISTPCDPYYVGLRFELLGCPVCETANDCTEFANGICENEKFCTYEGPTTPAETTTARLSTAGQATTSGGATTKAPTPQASTVVPVLTSTLEATVTQTQSPIEEKINEVTQNLPPKVKKVVEDLLLVRDDLDGVSATDPTTYPTVNITQNTIKAGLEVIRNITVKANTTQDNKLQVDIIKGAWNFLAAVSTSDKFVGNAQLLDEFMSVSSLILDEDRKEAWREVQKESVAGPLGIVTSVEDVATKIASGSTFNINLTISEPNIEGLIRGKAKEEFVRDGYMYTFPKGDPNEVSTEVTILKDEFEDNIRVTNSPVNSSLVVVVLKFSGIEKILDEDDLQDKTPEVQEKKRVGSDILXKGHDLIACDLQIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN37</accession>
    <name>A0A8B7YN37_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Ufm1-specific protease 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110980480</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C78 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092880.1">
        <property type="nucleotide sequence ID" value="XM_022237188.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092881.1">
        <property type="nucleotide sequence ID" value="XM_022237189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN37"/>
    <dbReference type="GeneID" id="110980480"/>
    <dbReference type="KEGG" id="aplc:110980480"/>
    <dbReference type="OMA" id="AISWIIN"/>
    <dbReference type="OrthoDB" id="417506at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF3">
        <property type="entry name" value="INACTIVE UFM1-SPECIFIC PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="20"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022092880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022092881.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24463" checksum="24695EEB3DBB1E22" modified="2022-01-19" version="1">MARLLNVHRDLPLPQDVGSKVAMVTGDYLYYHYGCDGIDDRGWGCGYRTLQTLCSWVRFRKLKLNQDSRQTEPSLREVQEALVAMGDKKPSLIGSKEWIGSYEVCICIDHFYDVPCKILHVNSGTELIDKIPDLLQHFQEVGSPVMMGGDTDASSKGIVGICIGQQQTCLLVLDPHFYGDPTFDTLTSSSYLLWKPLDSFMENSFYNLCLPIVKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSL8</accession>
    <name>A0A8B7YSL8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synaptotagmin 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094366.1">
        <property type="nucleotide sequence ID" value="XM_022238674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSL8"/>
    <dbReference type="GeneID" id="110981259"/>
    <dbReference type="KEGG" id="aplc:110981259"/>
    <dbReference type="OrthoDB" id="9947256at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094366.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24561" checksum="90B5CC524589BA44" modified="2022-01-19" version="1">MYPDRQRRVLSAPSKNSTGETLLVTADFDGVKSAVPSVTVCLCYRPHKNKFLVTVVKAKDLKKSTVRKDSYVEVNLFRGIGDKARMQTVRTKSYFGGRNPVYKEAFSFELPSRGLASVYTELSFTVRRHNLVRTDEVLGRVTLSSEMLLRWKKSQSLAGTLDEAFSVGTDWPAEGTSMEPRWNRAKELCWLTPARIPVACGAGAVLSFVFLFWAALPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSZ2</accession>
    <name>A0A8B7YSZ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-ketoacyl-CoA thiolase, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110982367</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096413.1">
        <property type="nucleotide sequence ID" value="XM_022240721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSZ2"/>
    <dbReference type="GeneID" id="110982367"/>
    <dbReference type="KEGG" id="aplc:110982367"/>
    <dbReference type="OMA" id="YVRVETI"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF107">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase N-terminal" evidence="7">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="8">
        <location>
            <begin position="110"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022096413.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="24698" checksum="6028CF76CE48F5B0" modified="2022-01-19" version="1">MCQRSVECLDIHIRAFSHVTFAVYIIILISANEEGRFKDEMAPIEMKSKKGVKVIDTDEHPRETSMEALAKLPPVFQKDGLVSAGNASGICDGAGAVILASEEAVTKHNLTPLARLVSYHVSGCDPTIMGIGPVPAVRRALEKAGLQLADMDLCEVNEAFAAQVLSVQRELGLDMEKTNTNGGAVALGHPVGASGSRITAHLTHELRRTGGKYAVGSACIGGGQGIAVILENTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YT06</accession>
    <name>A0A8B7YT06_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="23 24">Fibropellin-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23 24" type="primary">LOC110982020</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095832.1">
        <property type="nucleotide sequence ID" value="XM_022240140.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095833.1">
        <property type="nucleotide sequence ID" value="XM_022240141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YT06"/>
    <dbReference type="GeneID" id="110982020"/>
    <dbReference type="KEGG" id="aplc:110982020"/>
    <dbReference type="OrthoDB" id="406708at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000368">
        <property type="entry name" value="Delta-like 3 (Drosophila), isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000425">
        <property type="entry name" value="Eyes shut homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="22"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="17 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665618" evidence="20">
        <location>
            <begin position="30"/>
            <end position="938"/>
        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="938" mass="99978" checksum="FA9271CAD5B8A402" modified="2022-01-19" version="1">MLHRRSYSGGVVAVALNGMFCLLFSVSYAQECGNMGGVCQNNAECRQLNADQFYCSCSGAWTGEFCDQVNYCYNVPCNNMGICYNLETTYRCDCADGFSGVDCGIPLQQEDACSPSPCQNGGECLLQANDPTQALCLCSEAFSGPQCERDNPCFPQPCQNGGTCTASETSFSCACADGYTGTQCQSVAIDPCGSSPCLNNGICQSVGNDYICTCDTLHSGKNCETKIKPCDNDPCQNGGGCFNRVDDNTYFCVCPANFTGENCEEDLKPCQAIPCQNGGLCYNLGNNLDYVCVCTSGFMGTNCERDDPCLPQPCFNGGVCSYIGFSFSCTCANGYTGPQCEIPPPHPCDEGLNPCLNDGQCSSNDGLTAVCACVNGFTGSQCETVPPCHDTINPCQNGATCVEQNSAAVCICVDHYVGDRCQQEGPCHENVNPCLNGATCVEMNSAAFCRCTDGFVGDRCERDLPCNDQVNPCQNGAVCVNVNDTIAHCVCFNRFSGLYCELEPAVHPCNETVNPCQNGATCFPMNDVTAICVCIDGYSGQHCEIDPPAPPCHESVNPCQNGATCTELDSTTAMCVCIDGFRGEHCDQLGPCHESIDPCQNGATCLEQNSAALCICVDHYVGDYCEQVGPCHESVDPCLNGATCMEMNSAAVCRCTNDFVGDRCERVPPCHTTVDPCLNGATCIEKESSTFMCVCAGDYIGEHCDQVPPCHDSVNPCLNGATCTETGGLPEVACLCVGGHTGLYCEIPPDDPCDPNPCQNDGLCQGDLITGIHSCTCSANFYGANCETVVPNNCESNPCVNNGTCYSGKEMNGYVCTCVDGYTGLNCELETCRRIPCQNEGVCVTAESHDYCECREGWTGSQCQTKQVTCEVNTCQNDGTCLVLDNVLVCRCKGIYYGSRCERSNKNSNSDALSFHKRSSSTMKVVSLLTLVTITLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YT52</accession>
    <name>A0A8B7YT52_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nesprin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110981923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095660.1">
        <property type="nucleotide sequence ID" value="XM_022239968.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981923"/>
    <dbReference type="KEGG" id="aplc:110981923"/>
    <dbReference type="OMA" id="DANHAIC"/>
    <dbReference type="OrthoDB" id="6117246at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052403">
        <property type="entry name" value="LINC-complex_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535">
        <property type="entry name" value="MUSCLE-SPECIFIC PROTEIN 300 KDA, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47535:SF1">
        <property type="entry name" value="NESPRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1371"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1846"/>
            <end position="1873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095660.1"/>
        </source>
    </evidence>
    <sequence length="2229" mass="249319" checksum="6CA154BF56C66E1E" modified="2022-01-19" version="1">MMLHVLCLTYSKTNLNLIHELQAQCPEGQSKLNEFLDCTHQTLASTSDAGQAKLNQEATQLNDRWEKVLAKVAKSEAKLEKSLQQKEEHNMKKNEFEKWLAEKEVELEECFVLQADLPGKEGANHRCKRLVEDIAQQEPWLAELTHSAQQLLDTNIESISVRFHTLKNRANESSEHAYRALDHHRQFNQSMDYFQSWLAEAEQVLDDNKDVPPRMDRLKQQLQNLKNLEQSQDVGRQKVDDIATHADLVLASTAPPGQTTVQHYLNSQQQDLMALAGHTAQAKDQLQGVLEKWEEHSASCKKLSDWLMTAETTLVNLEKPCVYLEEKKTQLDKLMTLEENVVSHQADVEVVTPQAQQLTLLGVSDPGVSARAQDITDEYQDLCSRLKVALQQREEQVAHHQQLANQLQDMNDWLKAKQLELDQCSGLAADREANEDRIQQLQVVLATLPEGEAQLQSSMDQSAIVCPSTAPAGRDRIDQQLQMAADRLKALRQQAERSQHQLEEGAELQRNYEGRAKELREWMAGAEGALGEAELEGEVGEGQLEVKQAHLEKVKALCDESQELQPIRAQVTSLGQQLIASNPTAVHIGSETTRLTAGYQTLHMNLKDRLRQAERAVTEQQNFQSAVEDFYKWLRAARETLTNCRNVTGEKPDVSSRLQDLQELMSMRHRGQSLLNSASSKAERVLPQTAPDGQEAIQAQIAVMRGDYASLLEDTISVKDALESCVRDWNRYEASCDKLSRWLAEAKGQIRTASELKSTLGEKKVQLERSKAIQQDIASHQKDIDALTEHAKKLLDRNPDGLQPITEELQMFTDQYQASMDNIKLAVDNHALSVAEHKEFQQGQREFANWLREAKNKLTSLTDVSGNSKTVQAKLAALEDLLTAKEAGQEKLDSVTGSGGRTLPLTAAAGQETITQQLQKDQEELAALMASLLDSRDRLKECAGQWDVYEESQAEMDGWLRELEEQLGKGLELQPGLETKREQVNEFKALQETIQSRQPAVEAVSRQAQSLLDSSVGNVGVVSESTRLASRFQRLIMTAKDQLKKSEHNAADHAQYQDALNDFNSWLASSQEALDQNSGLLGDKLTLQDRAKNLKDLAATRGTGHNLLQALDHRAGKTLPNTAVSGQELLRQDTRAAHAALEELAASLIKQTQDLQQCLSLWDDFDGQYSQVTEELGEAEVILVKEPELAPDVKHKEQQLNRYQSLADEVAQQKESLDCLWAGAKELQRLTEEDEITKKATEMMERHKKLMQAAKAAVETTFQRAENHREYNDLNRALCHWLESTNQALRHHSCLAGTKDTLNQQLASVTELISDVPSCEEKLMQPTQALGGKVLAETSPDGCAIVQQELDQSSRDWSRLVGDADDIKLSLEGAICQWEEYEEEHERLVQRLNEAEAETSQELELKKDVAEKQEQLESLKIVYEDVLSLETSLNAVVLSADPILNNNPMDSTVSGQLSQARLRHQTLVNTMKAQVKLCQERVQDHTDFSLSLEESQSILSEAEQRLSPLQDISGDRPSVDAKLAALETMASHLTEFEAQVRCATDQGHHILPHTSPEGQEVVQGQVADLSVTLTSLVHGVKDAGKALVERVRCWSEYETAEEEFGEWLAETEKVLTQEPERKADLGEKKSQLERYKALESEITSHSINLQDAEQKALKVLEHDTGSVDVEGKTADLRARYQALCLRSKDVTDALTHSVTEHQGYQDALQEAEKALLDISQQLTTQGALPEGASLEDSQQQLSQLQGIMRQITACSAKLDQASVAGSALTSSAQATPTLTQHVGVELRAVEEGLEAVNQTANSIQARLQDLINQQQVYKETLQTCADWLQVAQQGWSVDEADAKAAVVIETEGLEDAQNQLKELQALLDTAVMHSQLVQAAEESLEDSSADLSTSQLSADVHQHLTVVTETVEARIAVAQQLSKQWKELEERKARLGEWLEQARGREEEERLQPAEVDVAKAKAHLDGVEDFLKEVKAKQAELAQIRDEQSHLCHRPDPDLDALDQGFKTLSDLVEQLADARRGELEDARGYLEARSAVEKVLDEAQKTMEEMEKDDFMPISEKLEKHQRTSSLLAERNELDALRECTRRVCGSTSPKERNAVQEFFSESTERWVSLGERARTGTHTLQQSLTDYNAFLDKAKESREWLKATEDQLAVGEMVGPAVEGAQEILDANHAICSDIASKKAVYLLVSSQADKLCQGLSRREREMVQQHMQQIGAQLELLEREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTA6</accession>
    <name>A0A8B7YTA6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcriptional repressor p66-alpha-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110981377</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094591.1">
        <property type="nucleotide sequence ID" value="XM_022238899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTA6"/>
    <dbReference type="GeneID" id="110981377"/>
    <dbReference type="KEGG" id="aplc:110981377"/>
    <dbReference type="OrthoDB" id="7331812at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040386">
        <property type="entry name" value="P66"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032346">
        <property type="entry name" value="P66_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455:SF7">
        <property type="entry name" value="SIMJANG, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13455">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR P66-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16563">
        <property type="entry name" value="P66_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="692"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="753"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="756"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022094591.1"/>
        </source>
    </evidence>
    <sequence length="883" mass="96997" checksum="1CA6AD9D3937103C" modified="2022-01-19" version="1">MIQNFEFLPWKEFFSVESRMSGMDELGPQDHAEGEKTASVVASSSQPSPIACDKNSTMLEEKSIHSVKRLWNTDADEAVETSKRARLSESEDNRIYDNVANEKLSHAIVAPVQNQDKDTNGDGRSDHIPQDTSNGALENNSPLTNNTKDSCLLETVDLRPDVHVSQRETSSVPREPSKSRSETSSTSRTETSTLSNSNQEESMDVDSDSPANSAPVKPSGLETQRTEATDNSKERLQDSDETESTDLCGEALEPKAKVSAAEPEEVAGVRPTITNNQTGASGTRDVKPKQSVSETPSRTENGSGTQKTVQRDLENGDGKPQTGNTADRQNMVKETLGEKVENSVDLKETRDKMKGDSTKEVPTSTGNKEHSRSSSPQDDVIVLSDDEVDGTPDGDDTSSIDTGPFSPLPDDDPLGKLTEEELAHRDKAIRDLQEELRTEEGKLLLLKKLRQSQLQPVQVLPKEGAAAATDSAGTSAVLPPQKPNPTPVINATLPQVLRTTPGAKIQLSAQQQQQQLQHLKQLQQLQQQHQQKAGSHAIQMPQLVRGSQIQTIGRSVLTPHSGPPPLVMVSRGGQPVQNTRHIIRVSGTGTVSTTSLQTAGSQLVSQQSRPSTTTANDSQSAASRQAAAKLALRKQLEKTLLQIPPPKPPPPELHFLPSAANNEFIILVGLEEVVNTILEVEKDSKRKTPQRFTDPFRCAQCKTDFTTIWKQDAKQGIMCETCIVSNQKKSLKAEHTNRLKTAFVKALQQEQEIEQRMQQGQNPVIHSSQQTSRQHHQSSQLQSARQRVMNPVPHQQQRTVLNPAPNTQRVMQPVTYTYIPHVSGVKNSNQAFAYRVPSSQIQMVSKNQISSSHHSAAARQREYLLDMIPSKVLNQNPAVPWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUU6</accession>
    <name>A0A8B7YUU6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110982402</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096462.1">
        <property type="nucleotide sequence ID" value="XM_022240770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUU6"/>
    <dbReference type="GeneID" id="110982402"/>
    <dbReference type="KEGG" id="aplc:110982402"/>
    <dbReference type="OMA" id="ATITIMI"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022096462.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="53402" checksum="2F5E0209BE089FD8" modified="2022-01-19" version="1">MMESGSRSSSIPSVSSSVGPSGRRSAGDEQVHLRRELGLLKAVSIVMGSIIGSGIFISPQGVLRGTGSVGLSLIVWLVCGLVSLAGALCFAELSIVTGKSGSQYIYLKEAYGNIPGFLYSWTSSLLMRPGGLAMVTLAMGAYLTDFLLPGDCPVPDTLIKLFAVLAIMFAGFVNAVSVKWTTHLQVAFTMSKVVALLVIVGVGLSQIIQGHTDAVNPSVSFHGSNKDIISLAAAFYQGLYPYDGWGSLNTVYEEVNNPKRNVPLAVIIGIPLTIVIYILVNISYLTVLTPDEVIASDAVAVAFAERSLGAMSWVIPLGICISTFGGSMCSILSDARLPYVTSREGHMAQFLSMISINRRTPLPGIGLEVLVALFLVAIGSFDTLLYGLSFAGWGFYGAAVMAVPVLRYRLPNRPRPFKVPIILPILVFLCSLYLIVSPFVNGPDMEIVYASLFILSGLLLYIPFVHFKYHPRVMRHVTLFLQKLFVAVPSDYVEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVN4</accession>
    <name>A0A8B7YVN4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ubiquitin-related modifier</fullName>
            <shortName evidence="2">SUMO</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110982566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ubiquitin family. SUMO subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096752.1">
        <property type="nucleotide sequence ID" value="XM_022241060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVN4"/>
    <dbReference type="GeneID" id="110982566"/>
    <dbReference type="KEGG" id="aplc:110982566"/>
    <dbReference type="OMA" id="IKVRDEM"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022096752.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12378" checksum="D3CC147E790FF476" modified="2022-01-19" version="1">MSDQVGQENKPGTNEGENAKGATSTGTDSIKIKVRDEMGTEVLFKVKMSTQMRKIKEKYCEKASKNVSNIRFLFDGETISDDTTPKELQMEAEDIIEVVSSQTGGRHTPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVU6</accession>
    <name>A0A8B7YVU6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SPRY domain-containing SOCS box protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110981805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095431.1">
        <property type="nucleotide sequence ID" value="XM_022239739.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095432.1">
        <property type="nucleotide sequence ID" value="XM_022239740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVU6"/>
    <dbReference type="GeneID" id="110981805"/>
    <dbReference type="KEGG" id="aplc:110981805"/>
    <dbReference type="OMA" id="VYFHISP"/>
    <dbReference type="OrthoDB" id="5951542at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12876">
        <property type="entry name" value="SPRY_SOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035754">
        <property type="entry name" value="SPRY_SPSB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF16">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="185"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022095432.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27256" checksum="2C1DB9C7502CC0E6" modified="2022-01-19" version="1">MSSVEVEQMSAFREYRADNWCWDRQNKSSDVHLSTNQLAAYFHIDAEEDSMGTAGVRGTQGFHEGEFYWEIIFTEPAFGTAVMVGVGTRKALLHTTNYQYINMLGMDDQSWGLSYKGTLWHNGTSQQYCQPFYENNTRIGILLNLYVGTLTFFKDGVNLGVAFKDLHHVGEDLYPLACSTAAETELELGVRSSRKLRLQDKCYSTILRHIGHNDNNIDILPLPHTMKHVLKVDRHNARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWH4</accession>
    <name>A0A8B7YWH4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17 18">Myoneurin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 17 18 19" type="primary">LOC110983064</name>
    </gene>
    <organism evidence="15 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097666.1">
        <property type="nucleotide sequence ID" value="XM_022241974.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097667.1">
        <property type="nucleotide sequence ID" value="XM_022241975.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097668.1">
        <property type="nucleotide sequence ID" value="XM_022241976.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097669.1">
        <property type="nucleotide sequence ID" value="XM_022241977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWH4"/>
    <dbReference type="GeneID" id="110983064"/>
    <dbReference type="KEGG" id="aplc:110983064"/>
    <dbReference type="OMA" id="LEACCEF"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000075">
        <property type="entry name" value="Putative zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001732">
        <property type="entry name" value="Zgc:162936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="13">
        <location>
            <begin position="41"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="212"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="659"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="681"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022097666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022097667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022097668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022097669.1"/>
        </source>
    </evidence>
    <sequence length="797" mass="89570" checksum="35B496CD46F637E3" modified="2022-01-19" version="1">MAASSLQITRREDGSYLYEFTSHSQHILQTLNECRQFPRLCDCTVLVETRTFHTHKAVLIACSDYFKSYFTTVPPETAGQPIVLDNVSARGFHLLLEFAYTSRMCLTMAVMEDVLSVAVNLKAASVLEACCEFLKSQLTGDNCVDIISVAETFNLTEIKRQANRLMCERLIELSQTYKKGSGPLLPESKEELENLISANKDALAAFDVNQQDLHQQESCDSESDDNGGGDETDSSCSDTPPMIADRLRPRVQTQPPNLDPARDRTLKVETKAALKSPVPRSLRQLPPRRRGRPRKNESAPRSTRLRKKLRGATFSITKARKEYVCRFCTLKFSKLRDLRQHYITEHSQCSRCTKVFRTDSELNRHLISHQKRDTARGPRRYVCTFCGKNCGYSSALKIHVRTHTGEKPFKCDLCSARFIQSINLKRHVLTNHQKDTPYECKFCNKKFSVFVYLKSHEITHSSERPFQCETCGAMFKRKSDLRSHNRVHSTDKPFTCEICLAKFKTTNDLKTHSLIHNDTKPHTCDKCGASFKRTGHLNRHMMIHSNNKPYQCETCGAQFNRKENLRSHQRIHSGEQPYKCSLCGASFRHLSSMKIHEKNHWSQRTGAPESTIMSQHDGGSSLQHIAALMGLQALSLPAGSNMPVSLQVSTDGQPAVAQLAIPPGHASPNPTPPLQSPSPHTPMSLHPQPHQQPHQQPQQPLQQQQQQQQPPNPGLQQLPQSTLSMHPPPTCIATLTSPMQSPMPLPNATRSPMPLGSHPPPSPHNHMSTPMSPGVNHAQANQVHSLQAYMMNTATML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWJ9</accession>
    <name>A0A8B7YWJ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LOW QUALITY PROTEIN: alpha-actinin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095666.1">
        <property type="nucleotide sequence ID" value="XM_022239974.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981928"/>
    <dbReference type="KEGG" id="aplc:110981928"/>
    <dbReference type="OrthoDB" id="18853at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000004">
        <property type="entry name" value="Actinin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand Ca insensitive" evidence="3">
        <location>
            <begin position="151"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022095666.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="24238" checksum="AF5BAF66430F35A0" modified="2022-01-19" version="1">MRRLWIFKSHVDEQEMTNQSLQEAAVSENKHTMXTMSSLRISYIQVITAVRRYINELDNHILVRDSKGITEEQLSEFWTSFSYSLQRFISRLKSFRLQNGSGKLDLPEFKQCLVSLGLVMDVEDTQDEEVCLIMKIVDPNKIGTGESVDTEGSFKVLAGNKNXILKEDLIRQLPPDRAEYCISRMAPYTGPDAVPGALDYMSFSTALYGESDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXN8</accession>
    <name>A0A8B7YXN8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">G-protein coupled receptor 54-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110983277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098098.1">
        <property type="nucleotide sequence ID" value="XM_022242406.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098099.1">
        <property type="nucleotide sequence ID" value="XM_022242407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXN8"/>
    <dbReference type="GeneID" id="110983277"/>
    <dbReference type="KEGG" id="aplc:110983277"/>
    <dbReference type="OMA" id="CYLRIGR"/>
    <dbReference type="OrthoDB" id="5981855at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF27">
        <property type="entry name" value="PROLACTIN-RELEASING PEPTIDE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="60"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022098099.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="40877" checksum="A20E8FF9088E41EA" modified="2022-01-19" version="1">MNSWNVTTTNSPSLVTVDTTNNFAVGPTDGLPTEEFVFSSAAKIALTVVISVVAATGLFGNAMVVFIVIRYKDMHTVINYSFANLALTDMTLLLLDAVPTAADTAGINLSALLGCRAPIYLQFVTAEVTSLTLAFLSYDRYRHILHPLETLHQRSSGTLLKIFLSIWLVSFVVQIPSVLFAGLTAEGACSEYNAPWGQQYFFSYIFLFAYIVPFSIIVMCYLRIGRKMREAGLPSSLTANRRRRTVNITLTVIILYALCCAPVHIVHMWMAFDPEVTPKSPRYVELHTVANVVMFFNSSANPFVYALIGQSFRKHMKGMVKSTAECHMKCVAPNPRIKSRQSETEPQTAHISSKQTVWSSENSLSTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY99</accession>
    <name>A0A8B7YY99_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110983391 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110983391</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098315.1">
        <property type="nucleotide sequence ID" value="XM_022242623.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098318.1">
        <property type="nucleotide sequence ID" value="XM_022242626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY99"/>
    <dbReference type="GeneID" id="110983391"/>
    <dbReference type="KEGG" id="aplc:110983391"/>
    <dbReference type="OrthoDB" id="197925at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025924">
        <property type="entry name" value="YHYH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF8">
        <property type="entry name" value="YHYH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14240">
        <property type="entry name" value="YHYH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YHYH" evidence="2">
        <location>
            <begin position="102"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="YHYH" evidence="2">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022098315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022098318.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="30604" checksum="E516E29E21C17ED0" modified="2022-01-19" version="1">MLCSVSVRYLFSGNRVDMITSKLLVALLVAAVASLSSALTDEQIVSFMTTASVETNTGQTGMVSIVTADRMHTITSNGVPDHPTPEYPNQGNPNDIVVQAHQWTVPVNPTVATSTTELPLGPISVAINGIPFFNPYTAKGEDAVLTETFDSCDGHPTNRGVYHYHKQPSSCVFDIVSGEPSPLIGVALDGFPIYGPIDENGVELTSADLDECHGRFVDGKYRYHTTADFPYIMGCFKGTYSGSAAGGRPPPGQGGGNDNDNSGGAGGHSGLKTIIGVILLGCTTAAFSINST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYA7</accession>
    <name>A0A8B7YYA7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110983067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097672.1">
        <property type="nucleotide sequence ID" value="XM_022241980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYA7"/>
    <dbReference type="GeneID" id="110983067"/>
    <dbReference type="KEGG" id="aplc:110983067"/>
    <dbReference type="OMA" id="NQIKWCR"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022097672.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="51144" checksum="6FF402036CA6A6B5" modified="2022-01-19" version="1">MAGSGEVQWCFSQVKGTVEEDVTDADIISTVEFNHDGELLATGDKGGRVVIFQREEQSKNCTPPRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIKWLNRQNYAHFLLSTNDKTIKLWKVSERDKKWVGSNLMEEDGTVRDPCQITSVRLPSVQPIELMVEASPRRVFSNAHTYHINSISINSDGETYISADDLRINLWHLGITDQSFNIVDIKPANMEELTEVITAAEFHPRECNVFVYSSSKGSIRLCDMRQAALCDQSAKMFEEPEDPSNRSFFSEIISSISDVRFSHSGRYMISRDYLSVKVWDVLMDTKPVETFPVHEYLRSKLCSLYENDCIFDKFECVWNGNDTAIMTGSYNNFFRIFDRNTKRDSTLEASRDSIKPLQVLKPRRVNTGGKRKKDEISVDSLDFTRKILHTAWHPKENIIAVAATNNLYLFQEKPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYM2</accession>
    <name>A0A8B7YYM2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">F-box/WD repeat-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110983469</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098443.1">
        <property type="nucleotide sequence ID" value="XM_022242751.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098444.1">
        <property type="nucleotide sequence ID" value="XM_022242752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYM2"/>
    <dbReference type="GeneID" id="110983469"/>
    <dbReference type="KEGG" id="aplc:110983469"/>
    <dbReference type="OMA" id="TLHRDFM"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="344"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="431"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="472"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="553"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="661"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022098443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022098444.1"/>
        </source>
    </evidence>
    <sequence length="719" mass="82101" checksum="313E7652A4D1616D" modified="2022-01-19" version="1">MEQPLQILSHPCHGRGDGLVPHQQQDGACAGPIMGAGLLGQWHAFKGRPIDNELDMEFHRQLDHVAVWIDKWNHQQKCLILEGLLTRSNYSQFGFLWTSLQPALHRDFMYTSQQLFPEHKFTPISTYVSRQTRARRAVRNYYHVGSAHLQRRSDVMRCNTDIGLTNPEELQATRQGKQSGKITLSRDHQFSRSTTNIKLPSIHSGHYHSRGDANLLSKSAPASLKRITDNAPAVRRHMQDRPRPNAPKEIPKDYSPVTAHNLPRLTKSLTQVQISHTRPTMSGTSPRNLPPIPVVPDEVWQLYHWYEECWNDVQRNEFLHKLLKRLDSRQLYFLCSSLALKQSRDFIALLPESLALRILQYLSPKCLLVAALVSRTWCRLASHDSIWKAKCDQVDIEIPLPSGNFRWKTVYRDNVFLRQNWESGNCKQIDVRGHTAKVLCVTFDGKSRLASGSKDSSIKIWDIHTGNLIQTLKGHTKGVWCLSFFTRYLLVSSSFDGTVKVWNLRSGICTRTMFGHDGPIWAMAQKGHFLVTASQDRTLKLWDMRTCLLEHTLVGHTQAVFCVDMDDDCTMVISGSADRSIRVWSVETGRYTKVIWASQTTSIMALSYHQGYFTCAVGETVSLWRLETACCIKTFEEHEKRVETIGLRVDSADNPDCPRGLMVTAGQDGMVKYWNLKSDKSKHTLESTCQINSIFFDETKIIGACSDYKLRIWNFNTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z016</accession>
    <name>A0A8B7Z016_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-crystallin SL11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098110.1">
        <property type="nucleotide sequence ID" value="XM_022242418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z016"/>
    <dbReference type="GeneID" id="110983284"/>
    <dbReference type="KEGG" id="aplc:110983284"/>
    <dbReference type="OMA" id="DISVWVS"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022098110.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22151" checksum="4E80A6252B7EF739" modified="2022-01-19" version="1">MPTYRLMYFNNRGRAEVTRLLFKLAGQEFEDVRVPHKDWPTEKSKFPLLQLPVLEIDGQQIPQSRAMAGYLAREFGFHGSDSWQTLMVEVICDTADDLLQPLGDVLFLEKDESRKAEAIKNYYENRAPVILECLEKYLVKNGGGDGFFIGDKISLADISVWVSLDVCFGQRKDILAKYPKLVKLSERVDVISQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0I0</accession>
    <name>A0A8B7Z0I0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Estradiol 17-beta-dehydrogenase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110983376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098285.1">
        <property type="nucleotide sequence ID" value="XM_022242593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0I0"/>
    <dbReference type="GeneID" id="110983376"/>
    <dbReference type="KEGG" id="aplc:110983376"/>
    <dbReference type="OrthoDB" id="9104691at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022098285.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15269" checksum="EDB1FBF031CFC7DA" modified="2022-01-19" version="1">MLVWAPFQSLNSASKFALEGLSKSLAPVLRKAYNIRVSILEPSAVSAPSLVEARSSRAFLDNLCAGWGQVPKDLFLDYFQKDLGPAMHASCTPEEVAQLLEDIVSSQDPHLRYQTNDKAAVKLVDPTGNSILKFFQAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z190</accession>
    <name>A0A8B7Z190_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyl-protein thioesterase ABHD10, mitochondrial</fullName>
            <ecNumber evidence="6">3.1.1.93</ecNumber>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Acyl-protein thioesterase ABHD10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Alpha/beta hydrolase domain-containing protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Mycophenolic acid acyl-glucuronide esterase, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC110983539</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19234"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>mycophenolic acid O-acyl-beta-D-glucuronide + H2O = mycophenolate + D-glucuronate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:62932"/>
            <dbReference type="ChEBI" id="CHEBI:66982"/>
            <dbReference type="EC" id="3.1.1.93"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:34180"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.93" evidence="6"/>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022098545.1">
        <property type="nucleotide sequence ID" value="XM_022242853.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098546.1">
        <property type="nucleotide sequence ID" value="XM_022242854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z190"/>
    <dbReference type="GeneID" id="110983539"/>
    <dbReference type="KEGG" id="aplc:110983539"/>
    <dbReference type="CTD" id="55347"/>
    <dbReference type="OMA" id="TISRWLE"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052382">
        <property type="entry name" value="ABHD10_acyl-thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16138">
        <property type="entry name" value="MYCOPHENOLIC ACID ACYL-GLUCURONIDE ESTERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16138:SF7">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE ABHD10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="14">
        <location>
            <begin position="73"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022098545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022098546.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="32961" checksum="E555B6A99F7CB148" modified="2022-01-19" version="1">MNIYRPVVQARHICKEFLALPSISLSQRLCVSAMSNSSANDQGAGGAPVIQHLHRQGNNTVAYRHTPGQNPGVMFLPGFMSNMNGGKAVALEKCCQQMGVAYIRFDYQGLGDSRGHLQPGGKAFDVWKSDSLAVLDDLTSGPQILVGSSMGGALMILLALERPQRIAALIGVATAVNFKQPLSYTEKDRSQEAGNPTAEEVMYVTPQDFVDKRYQRCLMEDQLQITCPIRLLHGMKDDTVPYMTSLDVAQRVASKDVDVLLRKDGNHRMSQERDLLLLTRTLETLVEKVQTDSILGGNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3V8</accession>
    <name>A0A8B7Z3V8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Carbohydrate sulfotransferase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110984430</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100322.1">
        <property type="nucleotide sequence ID" value="XM_022244630.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100323.1">
        <property type="nucleotide sequence ID" value="XM_022244631.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100324.1">
        <property type="nucleotide sequence ID" value="XM_022244632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3V8"/>
    <dbReference type="GeneID" id="110984430"/>
    <dbReference type="KEGG" id="aplc:110984430"/>
    <dbReference type="OMA" id="CRERHHV"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022100324.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="50020" checksum="6FC4BE9EFB4531B8" modified="2022-01-19" version="1">MTMSRGVIFIVTASIFVLFSLLMYTEVLSRHSKWFEHAPPETISQRSRLNGHPFLHLARPESTNHASGVSRRMKQRRYSAMNITKLTFADAERVSTAHPVGLKIMVLARMRTGSTLLGEILNQNPSLFYLFEPLHATDSMVHMRMMELSKMEASMAMLLRKLSNCIFPSEFMYDIYNWRIARGKSSTIRDMCEAKFKCNKANPTLFNAQCKRHKGNMAMKMIRANLETIKPLILEDHLNVKILHLVRDPRATANSRKRFYCPRKKIPPEQCSLYALGILENEPNLLKYKTVHKYCQWMRDTVQAALARPEWLRGHYKLIRYEDLALEPLRFTKDIYNFLGLPLHPQVTEWVRANTQENTNKSSKVFNTRKNSTQAAISWRNSLTFKEAKDVEKKCGDVMELLGYRSLGSEEDLTNYEVPVTSPLDIGADISFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5S6</accession>
    <name>A0A8B7Z5S6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import receptor subunit TOM40 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110984344</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100150.1">
        <property type="nucleotide sequence ID" value="XM_022244458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5S6"/>
    <dbReference type="SMR" id="A0A8B7Z5S6"/>
    <dbReference type="GeneID" id="110984344"/>
    <dbReference type="KEGG" id="aplc:110984344"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000005">
        <property type="entry name" value="mitochondrial import receptor subunit TOM40 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022100150.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="34942" checksum="6D1B81769DE50F5B" modified="2022-01-19" version="1">MPSPPIPGMPPAPPTTAAAPIPGMPGSQQQPATTNGAAGGIPNPGSFEDLFKKVKEIFPQPIEGCKLVINKGLSNHFQISHTLSLGAFSPSSYHFGTTYVGTKQISPTEAFPVMLGDIDTSGSLNAQIIHQLANRLRGKLVVQTQQTKWAVYQGELEYRGPTYTGTVTAANINLLDNSGIVVGHYLQSLTERLALGAEVLFHYGQGQRAAVVSLAGKYSTDKWIASGTVGMTACHAAYYHKGKDVQYGVEFESNFRAQESAAAFGYQIDINQANVTMKGMVDSNWTVAAVMEKRLQPLPFTFLLSAVLNHWKSQYRFGFGLMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6W3</accession>
    <name>A0A8B7Z6W3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galanin receptor type 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110984547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022100530.1">
        <property type="nucleotide sequence ID" value="XM_022244838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6W3"/>
    <dbReference type="GeneID" id="110984547"/>
    <dbReference type="KEGG" id="aplc:110984547"/>
    <dbReference type="OMA" id="KIAIMIQ"/>
    <dbReference type="OrthoDB" id="5864054at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="46"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022100530.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37507" checksum="200A02532DBAB47A" modified="2022-01-19" version="1">MSDTSHWEQVQWTGGFDNETEFWASGPRSPLQIAVNTSIACLAFLGNGLVIIVRLARHRMFSSTVNRLILHQSIIDAITAVVFFLHRVVKDPIPVVSTENNFHDELICRFLYVDVLLWAMYVASTSNLVIISLDRFLASCYPLKHRKIISSEKVKLTGAIPWGIGLAHGSHFLFLFEPHRGYCRKVPIDRTLELVSSIAVLTVEYLVPAIILLYTYSKMLVTLKKKTVHPANVRQNFFRSAKENVRKIALLVDSAFIICWTPAEFEFVAATFGIFVSESVYEAFSALVACNMVVNPIIYCFMYEHFRTQLKGVLRAGLRRNRVHDGVLPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8W6</accession>
    <name>A0A8B7Z8W6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 protein zeta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102109.1">
        <property type="nucleotide sequence ID" value="XM_022246417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8W6"/>
    <dbReference type="GeneID" id="110985409"/>
    <dbReference type="KEGG" id="aplc:110985409"/>
    <dbReference type="OMA" id="AVCMKEV"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="7"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102109.1"/>
        </source>
    </evidence>
    <sequence length="268" mass="30782" checksum="48BCC4F67B56FFCB" modified="2022-01-19" version="1">MEEKNCEDLAYMARLAEQAERYDDMVKAMKAIVMKDPELSAEERNLLSVAYKNVIGARRASWRIINSIQQKQHDTSTCMKQQVIESYRLQIEQELKDSCYDVLKILDERLIPSAMNSNVTESKVFFHKMKGDYYRYLAEVSPQAEREEPTKKAQEAYCCACEDASPLATTHPIRLGLALNFSVFYYEIMGKQDKACEVAKKAFDDALAELDSLREDTYKDSTLILQLIRDNLTLWTSESESEGRSGTMRHGCKLEWSGRESGFDTDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8Y9</accession>
    <name>A0A8B7Z8Y9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110985430</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102134.1">
        <property type="nucleotide sequence ID" value="XM_022246442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8Y9"/>
    <dbReference type="GeneID" id="110985430"/>
    <dbReference type="KEGG" id="aplc:110985430"/>
    <dbReference type="OMA" id="CKRWKYS"/>
    <dbReference type="OrthoDB" id="5803771at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF60">
        <property type="entry name" value="SI:CH211-15D5.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="2">
        <location>
            <begin position="17"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="3">
        <location>
            <begin position="170"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102134.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24472" checksum="B879C9D889A6CF4D" modified="2022-01-19" version="1">MAADHKPDATGHELDVQTISAVREFPCLYDPSSKDYRDNRSVIEAWTKIAEICGANDWTECKERWRKLRDAYVKVKKKTSIRKPGTYKTPWVHYDSMSFLANYIKHRNVTKRPLDTDEDVDGMSAEETLEAMVANPPKGKRGRKIDPMVTIVETIGQASNTKMAADASMDDEDGLFGRMVAATLRRFPPRAKARCKFRIQEIIFQQENENLGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z992</accession>
    <name>A0A8B7Z992_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110984205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099836.1">
        <property type="nucleotide sequence ID" value="XM_022244144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z992"/>
    <dbReference type="GeneID" id="110984205"/>
    <dbReference type="KEGG" id="aplc:110984205"/>
    <dbReference type="OMA" id="GINRWQD"/>
    <dbReference type="OrthoDB" id="6432391at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21974:SF2">
        <property type="entry name" value="RE15880P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="514"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099836.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="63357" checksum="9E828C8B577804B4" modified="2022-01-19" version="1">MGCAASEMSTVQQPKPYPVKQPAQATYPVLAPQQVPQQQVPQPVLSTAPQQTMVPQAAPPVQQAPPPQQAPPPPQAPAENKDDEDIQPEPVEINEALIQLLVDMDKEISSLESRNVTKQYQLKVDQMNRLTAQVQAMAQEQQALAQQTQKEYQDVVNLQNMQSTRQMMTQGQYTAQMSKEQEEYMQALSKQEVHKKELDATGRQLEAFKREVASLKAESDRIRELYDKQDGILASIFDGKYGSEREYSLESDLDIALERKQRVGVAKYKWQNAKVLLQHAGGQLGFAIRRWGDVMQIPPQNVDIRYKFAAECRNNLVAASQNITSSQQYLNTIRFPYCTPDEIKTLNTAINHIFTDLLTPERHKHAMECYVTVYRRTSALIQWCDHVINKTILKDLESATKECATKQQELKQERLKLIKEKVREKLGNDAADRIQLTSEGGAEAENVDQDEAELLMLVEADAVSQAGDLATLAPESSGPSAITPLPLNELAPTPSMDDLFGNIDELKKQHEDNVRELQRQQEMAKARVDQDLQSKLAKRRSRRRRMQQQETEMQSLADKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9Q7</accession>
    <name>A0A8B7Z9Q7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110985097</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101545.1">
        <property type="nucleotide sequence ID" value="XM_022245853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9Q7"/>
    <dbReference type="SMR" id="A0A8B7Z9Q7"/>
    <dbReference type="GeneID" id="110985097"/>
    <dbReference type="KEGG" id="aplc:110985097"/>
    <dbReference type="CTD" id="23595"/>
    <dbReference type="OMA" id="YCLMEHY"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045663">
        <property type="entry name" value="ORC3_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19675">
        <property type="entry name" value="ORC3_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 insertion" evidence="13">
        <location>
            <begin position="376"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="12">
        <location>
            <begin position="619"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022101545.1"/>
        </source>
    </evidence>
    <sequence length="735" mass="83523" checksum="E232475BE363A1C4" modified="2022-01-19" version="1">MCADSLQTSSVSKGCFVFKAKMAKKALRPGDYMCQDGSDSEAAWFRCNTYEALWDRVSEGIEALQSEVNEEIFSDLIQFVKNGQAGFEPEGTLPGQRPQRVIKEIPTAAFIAGVNVTDHSATFAAITTQLKDQVTPHVANLLSRDCNNLRALMSSLVSQLMGTDDVISDDEEELNIKKIPATMPVLRAWYHDTAKKRKAQQGEASPPKPAKKSQRSKKRRSSSTFNKNYAEFPPVVILFEDLESFTPRVLQDFILICSEYLSQLPLVLLFGIATSVAAIHRILPQAVSSLLSIEKFQAKPSTVYLSQLISKVLLTPSHPFKLGHKVFQLLLDIFLFHDFSVINFVKGLQFAMMDHFFSHPLSLLCCNYGEGLNRLRTLAHDQLELFRQAASFRTFVEGQPPEQQRALLLDDKHLKKTLQELLKKLVDYHRAFYPLMECLNILTGQLPHHPLGKQQRELYSMCLEGNVWESAGYKEAFSLLKLMARDELMALLEKCIERLTCSDNPLQDARFQLETLHTRLATIAEDDNKPQEEVREEVSEESRSKTERVTLRSLQQKLMESVKKTRKPTKYESLVNETLEFFDSIFRKHLVCPNTLTFHEIFYYNSVSDVRHHINASPRAAIQTALNNPSHYLQSELCKAEPGVVLSTMPDVCIAYKLHMECGRLINLYDWLQAFITVVTGEQEQDEGSHDNSKKPDPQLQARFIRAVSELQFLGFIKATRKKTDHVARLTWGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZA77</accession>
    <name>A0A8B7ZA77_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Thyrotropin-releasing hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110985270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101872.1">
        <property type="nucleotide sequence ID" value="XM_022246180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZA77"/>
    <dbReference type="GeneID" id="110985270"/>
    <dbReference type="KEGG" id="aplc:110985270"/>
    <dbReference type="OrthoDB" id="6088609at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14978">
        <property type="entry name" value="7tmA_FMRFamide_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="65"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022101872.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41314" checksum="B58C5D13BCE9C083" modified="2022-01-19" version="1">MLNASFADFETHQGVRNQAYIAFSHSLVFVNETDLSKARSYIYDPTSTAIYGYVLPIIKLFGLLGILTFYFMVYRVREMRNLTNFYLGSLAVADLMVLLTSGSLLQYEALVTRTFSNKNYLGPSAGLVFDIKTLFTQIAIFASLFCVVVVTYERYLAICHPLKHKHVQGMKRAFRSVVFAWSASLVVPVFDFAIFRTLTEARCVVFPNDEEFDNLSGLFQLTALDINYARAKVVFENISYLVVYLVTFVANATLNGLIIHKLWNPNSPGRSSKLSGLHQVTLMLVLNSTVCFATLLPLTVSSLTNTFKPEAEFGDKVIAIPPLFVVLNSAINTVLFNVGSRRYRNAFLEAFRCRSRERKPQSNDIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAI0</accession>
    <name>A0A8B7ZAI0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110985748 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102684.1">
        <property type="nucleotide sequence ID" value="XM_022246992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAI0"/>
    <dbReference type="GeneID" id="110985748"/>
    <dbReference type="KEGG" id="aplc:110985748"/>
    <dbReference type="OrthoDB" id="5987687at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102684.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="50409" checksum="6A415800026C0CD9" modified="2022-01-19" version="1">MTDAVARLGRSWHNSRSNYIFIQSQLAPLARHFQFIVTVLVCHTYRAIAPQILSKHSGKMNPRIRHIPNIDDLPRRRLFNQEEMLAELDRVSSPEEYNSGQLQSTGNGRTMLDISQSRPAIRVSYSQASTSSTSDAPLNTLGFPQATSTPTSSDSESESQESASSILSERSAHSSSSLNTSAGSISVGSSAPSAVTLRMLYMQNKKLEAQLKKQNEELQDIKRNMRCAAANSGSKRVAVPRECSQAVREVYGKLYKDGTGGFNLSLTKTCQENELVVSTIVREVRSLHGREKWTCDQVRKAAKTYFSSLRDRKRRVDGGTYERHAKAAKKRSRKFRKLQRRQSAMRNSDLSEDMKRQLNEVMTIDFMSSEESMSEDEEEGASRNKTRRLLKLPWERSKLTSLKHKLDSQFAKTAPPVVSRLLPEFVISNVPSSRPPPASAPSWAVRPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDJ0</accession>
    <name>A0A8B7ZDJ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Syntaxin-binding protein 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110985903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103042.1">
        <property type="nucleotide sequence ID" value="XM_022247350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDJ0"/>
    <dbReference type="GeneID" id="110985903"/>
    <dbReference type="KEGG" id="aplc:110985903"/>
    <dbReference type="CTD" id="252983"/>
    <dbReference type="OrthoDB" id="6022242at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06692">
        <property type="entry name" value="PDZ1_GgSTXBP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000034">
        <property type="entry name" value="syntaxin-binding protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051342">
        <property type="entry name" value="PDZ_scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964">
        <property type="entry name" value="MULTIPLE PDZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19964:SF94">
        <property type="entry name" value="SYNTAXIN-BINDING PROTEIN 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="817"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="609"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022103042.1"/>
        </source>
    </evidence>
    <sequence length="870" mass="95265" checksum="D96C6E89EC318C89" modified="2022-01-19" version="1">MSVTMTVTETGVSAVEGSPRHSHHMDETETVVFNDCKTGLGIKIIGGRSEQESGRDYGIFIRRVIPGGLAEQSGRLKEGDQILSVNGTSLLRVTNDEAVQHLRSASATNQVTLVVTRNMSAVRRFSLLIESQLANTRNTFSLDSQSISSDQGSDVHEQSSRPWSSSQRERTSSQSPSPSLDSASSVPAERAPSSANQRTPDVREIILNKLSGLGLSISGGVDRPDGPGIYIQGIQQDGDCARDGRLRAGDQLMSVNGEPLSGVTNEVAVEILTRASCRTDVDTLCVSYTPAMSARSCRQPSNHTPTSSYPSPSSTNQPLSPHRYPSHSTSPSQPPLHTGHQHQQGSPFAKTSGVSPHVVGDVVSSQGNIPESSSGERLSPPVVRQLMSPPRYEQATINGYPLSALHHQAPSNIAMPLYLQRHLHIQPASSSTPQADSTSGHLNRFPAPHSSHLEPSPVLPTSSVTVATHHHNTQSSAASPLATPPIGTSAISPSPSQTSSRRRRLSLDPHVRLRIDKLQVALKYLGIDPTDEEKVELRRRLKVDQSGMVPYGEFVAIARQIFKMQLDDSRFGAGSLTFAAQDVTDFAEPPLFQEQPQQVLPSSVPVSELDRVRRERDEALREIERLKVQLQEKDRSFNIAEEELLRIRKEAQGAIHESRALKSRVHLAEAAQREARNIEIDYEEVVHMLEAEIAILQKKISKTPPPNKVSSAGVEELDKRIAVMSCELRKAEISKKTYEVATEKLLQFAELVHECVSHGPNAIMVNQTRGRGESARRGDTGFIPPGYLAKHNKQGPLNLATEAKETVKAVKKLLDVEPLPYGWEEAYTADGMKYYLNHVNQRTTWIHPVSSINHLPAIEENGRDLPETKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDP0</accession>
    <name>A0A8B7ZDP0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WD repeat-containing protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110986315</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103779.1">
        <property type="nucleotide sequence ID" value="XM_022248087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDP0"/>
    <dbReference type="GeneID" id="110986315"/>
    <dbReference type="KEGG" id="aplc:110986315"/>
    <dbReference type="CTD" id="80232"/>
    <dbReference type="OMA" id="GHISGCV"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000087">
        <property type="entry name" value="WD repeat-containing protein 26 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="7">
        <location>
            <begin position="100"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="321"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022103779.1"/>
        </source>
    </evidence>
    <sequence length="578" mass="64711" checksum="028A511AA462DFB1" modified="2022-01-19" version="1">MQSNSTAAVHNGDASVLNSNGANMAPEPVISNGVEAASAAGSSSSAEGISRNPRAKQLSQCDRDIVRLIGQHLKGLGLTQTVEQLMIESNCRLEDPSASKFRAHVMAGEFNKAEEDLEELKPQMTCPQSLMKMKFLLLEQKYLEYLEESRILEALQCLRQELTPLKFNTERVHVLSGFLMCTSKEELHRRADWAGKGHASRTKLMEQLQTFLPPSVMLPPRRLYTLLNQAVELQKHRCPYHNTTIKNDDSLQSISLLHDHICSRNQFPSKCRQVVPDHCDEVWFCKFSPDGTKLATGSKDTTVIIWDINQDTLELKAIKTLEGHSYGVSFLAWSPDCKYLIACGPEECSELWVWNVETGESKTKISQSPEDSLTSASWNADSKRFVTGGNRGQFYLCDLDGNVLESWEGVRVQSLCIKGDTNVVLAADTHNRIRAYNFEDLTDQHVIQEDHSIMSFTISSNQRQALLSVAYQGVHLWDIKDKVLVRKFQGVTHGFYTIHSCFGGVNEKFIASGSEDNNVYIWHVKDEMPIAVLQGHTRTVNCVAWNPVLPNMLVSVSDDCTIRVWGPDESEGDGSTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEB1</accession>
    <name>A0A8B7ZEB1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110986437 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103979.1">
        <property type="nucleotide sequence ID" value="XM_022248287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEB1"/>
    <dbReference type="GeneID" id="110986437"/>
    <dbReference type="KEGG" id="aplc:110986437"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022103979.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="17707" checksum="C5286E47FFB8A459" modified="2022-01-19" version="1">MEPTTVSSTVEPTSPTTPPTSHSTNVGEPKSGLNIPIAALAGIGVGVFVAVLLVALLVIWKVKISKREPFSRGGNFTDGVMPYSDETSDPTNNMLHSEADRGAVQGVYPSPYASSPYRMDGGAGEEFGCGDSCVCDNDLRIHKVDFSKLDLIDLNHADLGSVAPSGITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZG03</accession>
    <name>A0A8B7ZG03_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger C2HC domain-containing protein 1A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110986714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104534.1">
        <property type="nucleotide sequence ID" value="XM_022248842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZG03"/>
    <dbReference type="GeneID" id="110986714"/>
    <dbReference type="KEGG" id="aplc:110986714"/>
    <dbReference type="CTD" id="51101"/>
    <dbReference type="OrthoDB" id="10066537at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026319">
        <property type="entry name" value="ZC2HC1A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049899">
        <property type="entry name" value="Znf_C2HC_C3H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555">
        <property type="entry name" value="C2H2 ZINC FINGER CGI-62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13555:SF36">
        <property type="entry name" value="ZINC FINGER C2HC DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52027">
        <property type="entry name" value="ZF_C2HC_C3H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC/C3H-type" evidence="7">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022104534.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="44255" checksum="FA407870E8821761" modified="2022-01-19" version="1">MHDAVRKRVKSSPKIETLVKSSRVKLSPSQIVPVGTPPPVFPCDICGRSFIEQTLQRHIKICEKNAVKQRKPFDSFKQRAAGTDIKTAPKADPKKLEKAKRATANWRNKHEELVSTLRAARGVTHAMKTGAPLPPPPSQSKVNPDYVQCPTCQRNFNESAAERHIPWCKEKNKRIGTTSNKTAAEKEKMAIRTQYKPPLPGSKKRQIVPPKAGPALRTGRTGSGSNMQHLEDQYSNMSVNEKTSSGRGRTKPGQSGGYGTVNGSKARSASLERRLEKSSDNYRSSSGDSVRGKRYTDDEDEYDYNGYGDAADRYGRRKAGSNHILPHQRVKAAKVQRSTNSRTPTPPSKYSSGSIQRKPSLENVNGRRASKFCHECGTQYPVAQAKFCCECGTRRAFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGV8</accession>
    <name>A0A8B7ZGV8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Flocculation protein FLO11-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC110985635</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102476.1">
        <property type="nucleotide sequence ID" value="XM_022246784.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102477.1">
        <property type="nucleotide sequence ID" value="XM_022246785.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102479.1">
        <property type="nucleotide sequence ID" value="XM_022246787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGV8"/>
    <dbReference type="GeneID" id="110985635"/>
    <dbReference type="KEGG" id="aplc:110985635"/>
    <dbReference type="OrthoDB" id="10072587at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026657">
        <property type="entry name" value="DDA3/GTSE-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032768">
        <property type="entry name" value="GTSE1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21584">
        <property type="entry name" value="DIFFERENTIAL DISPLAY AND ACTIVATED BY P53 DDA3 /G2 S PHASE EXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21584:SF9">
        <property type="entry name" value="G2 AND S PHASE-EXPRESSED PROTEIN 1 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15259">
        <property type="entry name" value="GTSE1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G2 and S phase-expressed protein 1 N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022102476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022102477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022102479.1"/>
        </source>
    </evidence>
    <sequence length="688" mass="73905" checksum="18F3D45450D6645B" modified="2022-01-19" version="1">MQSSGEDHLHTTEIMTERCSQDTQNSNGSTPWTYLADEHLIDREKFDFDLPVSPVESEKVEVDDEDEVFFGPVGFTEACIAKKTQLHSQSPNECKPMSPLNVEQYLELFLEANKVAMELTKEKKRDASQGSDDQGCTGKETGAVDDFSKKTEESTVGGVVADSQKQSEQSTGAKPSTEVSDCHIERVAVANLPGKTDVRNFKRLVRKDMRSPRRGTYTISVSPANTPPPPHLPSADDCVSKLARDKPQTLTFTAAQSNKQLSLKAPKSKLPVKGTQRSKLPLKGGLKKLVPPPNPSSGTSTDKLLRKKLSSPPKRKRLNSCESEDLISEASSSLASETSDTPSLSLGQPKGKRPQPGSFHTKGTTGPHPPTKAATSSSTVASSQHKSTDKAAAVNSVKAPAAKPRLLQQGPLQRRVVQASRQLKPVKPGQRGFLQSANRPQPVKAVVGLVKVPSANKDASEATPKKAGNLRQTPSRKLCTPTVSTPVHQDKKVVPKRLLTNEQSASKPAARSLSTSTMPTPQSKLMPPSTPSRSDSKVVPASASSMWRRSGIPTPSRRSIASSSRLSSTSSTISNPSPVQFRALRTSTTTSSPSGSPPPPKPAPPTAKEAIIKLDLDSSPACTKEVTLCDGRAPLETKTNLQEGKTNSPVVGLLVDIIPDPEEKVHLSKDAVSREGSRLYKENLIDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIH9</accession>
    <name>A0A8B7ZIH9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110987179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105364.1">
        <property type="nucleotide sequence ID" value="XM_022249672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIH9"/>
    <dbReference type="GeneID" id="110987179"/>
    <dbReference type="KEGG" id="aplc:110987179"/>
    <dbReference type="OMA" id="DNGANEF"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="10"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105364.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="56292" checksum="54104A9A064FF0DE" modified="2022-01-19" version="1">MEPHTDSGWSWVVMFGAFLVNFTGIGVVMSRGVYLNVWMEDLEASATSTSLVVSIGALMMALFSPVSGALCTKFGPRMLTILGGVLIMGGAIVSSLASTVSLLVIGNGFITGLGASMAFVSSFQGLALYFNHKFTFASGMASVGISFGHLAFPPLNTYLIDVYGWRGSLLITAAVSMHVAVAGAVMRPVALMTAANKKNADLNANVSEAEVGVTEDNREPDNNAPKPLTTTQGNGQALVRMVIERSTSDNSQQFLRIPPGADLPSDEDSTKDDEKDSARDNGANEFSQGRRSGFRDTPHSIFESSVRRLLVFKHFLFVTCGMKHFVLTPRFKVVVIVGFCHGFGKLSLVYVVPRAETVGITPERASLLLSLIGAGSVVGRLSHGWFIDRQYVTAEMTFAWTLLLFCGSIFLVPAFDSFPPLGVLAVMTGIGYSVSACLLVAIVRTLMPSASDTAAAVGFLILFWDVGEIIGLLLSGVIYDVLRSFDVAFVTGGVVLLLASSAAFVMYFRKRMKYCKCEMNRAASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZK51</accession>
    <name>A0A8B7ZK51_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Junction-mediating and -regulatory protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC110987119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105260.1">
        <property type="nucleotide sequence ID" value="XM_022249568.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105261.1">
        <property type="nucleotide sequence ID" value="XM_022249569.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105262.1">
        <property type="nucleotide sequence ID" value="XM_022249570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZK51"/>
    <dbReference type="GeneID" id="110987119"/>
    <dbReference type="KEGG" id="aplc:110987119"/>
    <dbReference type="OMA" id="PGEECSW"/>
    <dbReference type="OrthoDB" id="6284683at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031738">
        <property type="entry name" value="JMY/WHAMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031808">
        <property type="entry name" value="JMY/WHAMM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330">
        <property type="entry name" value="P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330:SF10">
        <property type="entry name" value="WH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15871">
        <property type="entry name" value="JMY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15920">
        <property type="entry name" value="WHAMM-JMY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JMY/WHAMM N-terminal" evidence="9">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="JMY/WHAMM middle" evidence="8">
        <location>
            <begin position="167"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="525"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="324"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="625"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF15920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022105260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022105262.1"/>
        </source>
    </evidence>
    <sequence length="777" mass="88814" checksum="104121F83D2E57AA" modified="2022-01-19" version="1">MLEEPHSLEDWVAVKEAPFDSDEPKKTSLRFLVNWNPHERNLSITCHESRPRNVKRTLKNSAKSAPRADAVRSPEDLRSWSGIFTLQDISYAHQQLCLVKPDLERHPPNVPYEPRGFWSLLYTVEVPDDFDQQLELYLSAAAQICGNKLLTDYLFNRDPVADEQYFENCSELRQKAYAEHETRLVDRLRESLKRSTDLVTMLDMIELYSEIDSNLAELAVARAEAFNVMLQPFLDMRELSFNRLLRLQDELEDEFMSQGRREKCLMEYSEWQEDYVGAIESINEIRVKYFARCIQTTQDVISQLENDKHKFGKSTWAMCGEDRLRDIQQMLSKEKIQLLQAKQERHKHHIEKIQQEMAMLDEGPNYVNELESLEQLAFDLQIKLYDTQLDVLNERDKMHRRELAVIKQQLREAEEVDVFFDALDSLLDIDLEAGEDDVDEEEVRLNRKGKKAEMDPRVADIQAKLSKINRQRARIRSNKQSCVAQQRTKIDEKKLEEEKFKSHHWVQMKRQQLWAEQEQKKDFIQSQRKKTLDRLRNYKVSHPSPKMLKPQQYKNGAKKREASSKTGAELGKAEEKKKAAAARDKARRSYQPPKPVASKTKSSKATNGTVPGAVPATRGNQPLALPQPDPPPPPVPPPPLAPPPPLAPPPPLAPPPPPPACPPTLALLAGTRDPKTVDMEKKDTGGRGLDLSAILKARGNLQKCPADHSGGANQDPMVATLANIRQGVKLRNIQRDPKGTSSPYNSLENTELMAAINRIRNCTEIEVDSDSDVDFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKN2</accession>
    <name>A0A8B7ZKN2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">small monomeric GTPase</fullName>
            <ecNumber evidence="4">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17 18" type="primary">LOC110987303</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022105602.1">
        <property type="nucleotide sequence ID" value="XM_022249910.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105603.1">
        <property type="nucleotide sequence ID" value="XM_022249911.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105605.1">
        <property type="nucleotide sequence ID" value="XM_022249913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKN2"/>
    <dbReference type="GeneID" id="110987303"/>
    <dbReference type="KEGG" id="aplc:110987303"/>
    <dbReference type="CTD" id="5873"/>
    <dbReference type="OMA" id="MHAYTED"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04127">
        <property type="entry name" value="Rab27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000402">
        <property type="entry name" value="Ras-related protein Rab-27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041837">
        <property type="entry name" value="Rab27a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022105602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022105603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022105605.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26284" checksum="A608DC47E17F7741" modified="2022-01-19" version="1">MGDSTTVSPSSNTMGSEYDYLIKFLALGDSGVGKTSFLYQYTDGTFNSKFISTVGIDFREKRVMHRPKGVADNMSRGQRVHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFINIRNWMTQLQMHAYCENPDIVLCGNKSDLEENRAISDERAKEMAEKYGLPYFETSAKTGNNISKAIECLLDNVMLRMERSVDKSQFPGAVVAHGNGRGLPMEVDEASEGKSGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLP1</accession>
    <name>A0A8B7ZLP1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="22 23">Aminopeptidase N-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">LOC110986589</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104256.1">
        <property type="nucleotide sequence ID" value="XM_022248564.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104257.1">
        <property type="nucleotide sequence ID" value="XM_022248565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLP1"/>
    <dbReference type="GeneID" id="110986589"/>
    <dbReference type="KEGG" id="aplc:110986589"/>
    <dbReference type="OMA" id="MQYIFES"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF301">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="20">
        <location>
            <begin position="113"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="18">
        <location>
            <begin position="346"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="19">
        <location>
            <begin position="654"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022104256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022104257.1"/>
        </source>
    </evidence>
    <sequence length="1005" mass="116767" checksum="59FC25CE040092AD" modified="2022-01-19" version="1">MGRSEFSMEDNPGRKGNGVYCSPAVLVFSIITVGVMIAATALMTYYIPRSLNNDRATKEPIVQLPSTTENMIVPTDAPIMMSTKQVVTEPPAKPTTIPPSDLMRGRLPKTVLPRRYEVNLRPFLYDDDVVDSKLGERFTFDGWVRIKVECIEPTNEITLHSKNITVHGIPTVVSVSTLDKMDLFESYKMVDEYAFMILKLKKMLMPHQEYDIYMQYSGILGDDEAGFYPSKYLDEFNNTRYIATTQMEGPFARRVLPCFDEPSFKASYDVQLEHRHDMQALANGIATRKLRLDGHWSRTYFKRVPSMPTYLLAFIVHDFSSINVTNANGCLIRIWCQSDLIHLAPYALNVSDKVQTFFDDYLDNEYPLAKQDHIAIQEFGAGAMENWGLITYQDIYLLYGMEDFGNNMFYSEIITHELAHMWFGNLVTLEWWDDLWLNEGFATYMEHIGVNYVHPEFKKFQTFYLDNSNVALHYDSFGTFPALRAPVYADDEDIDYQFNSITYQKGGSILWMMEHFLTIEVFNQGVKNYLKERAYKNVNAEQLWHELTYADKEVGKHDVKKIMDTWTLQRGYPLITLTRTGNSMVATQKVFLQFNRTIEDDGFGDLGYKWYVPLTCVYKSGPADQYEKPQQVWMEPSDDYTYFDLPDDAKSDDWYLANAMMTGFYRVNYDDDNWQRLMDQAEMDPNVFSEENKVGLIYDSFILALVEVVPISYYNSFLSSFTNNSRRARRAAVSTSSYFVKMLDTRGAIKKRSAPLAQTYMLQLIEPMYVESGWDENFVLDFLPAGIRHEKSDRFDVTSTACRYGNQHCVTKATSMFKEYMSNPINNAIPENLRTCVYCNGIRFGKKLEWNFAYDMLRTTDDRRERTRWVRALTCSADTSLLQSYLQSMMDSNTFSRRDVEIILMGVAENPDGYEVAWDFLRNNWGTVSKMFKRKRQSLCDIFEEITSFFNTEEQLEELLEFSKGRNLGALKYTYESAITTTQVNIRWMEHSAFETEEALRRRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP60</accession>
    <name>A0A8B7ZP60_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 50A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110988202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107209.1">
        <property type="nucleotide sequence ID" value="XM_022251517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP60"/>
    <dbReference type="GeneID" id="110988202"/>
    <dbReference type="KEGG" id="aplc:110988202"/>
    <dbReference type="OMA" id="GYVVPQK"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022107209.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17716" checksum="73BB97B2B0EF6351" modified="2022-01-19" version="1">MSGCLDRVECHLPEWCELGEKRNFIASVAAGILFFAGWWLAIDAAACYPQDDKLVKAYHVCGVVSTIAFFMINAVSAGQVRGDSYNTGCIGQRGARLWLFVGFLLAFGGLIGASWILFGPYVVNKQFSESYPGIAIFFQNFLIFVSGIVFKFGRTEDLWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP72</accession>
    <name>A0A8B7ZP72_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="22 23 24">Neuronal acetylcholine receptor subunit alpha-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22 23 24" type="primary">LOC110987075</name>
    </gene>
    <organism evidence="21 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23 24" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105189.1">
        <property type="nucleotide sequence ID" value="XM_022249497.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105190.1">
        <property type="nucleotide sequence ID" value="XM_022249498.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105191.1">
        <property type="nucleotide sequence ID" value="XM_022249499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP72"/>
    <dbReference type="GeneID" id="110987075"/>
    <dbReference type="KEGG" id="aplc:110987075"/>
    <dbReference type="OMA" id="ETHSMPR"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007271">
        <property type="term" value="P:synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000005">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000022">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit alpha4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044519729" evidence="17">
        <location>
            <begin position="28"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="31"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="245"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022105189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022105190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022105191.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="57503" checksum="A609E18DCD107263" modified="2022-01-19" version="1">MDAISFCAPLAVLLHVMFSIFAQGCLASEAEERLFNTLFTGYNRLIRPVRNNTETLVVDFGLTMSQLIDVDEKNQIMTTNVWLKQQWNDYKLTWNPDDYDGISILRVPALMIWLPDIVLYNNADGKYEVTLMTKALVYSDGTIYWLPPAIYKSSCKIDVRYFPFDEQECIMKFGSWTYDGLLIDLMPLGGPDVDLEDYWPSGEWYIIGTPGTKNTVKYPCCDEIYTDITFNMIIRRKPLFYTVNLILPCVLISFLTVLVFYLPSDSGEKITLCISVLLALTVFLLLIAEIIPPTSLLIPLIGRYLLFTMVLVTLSIVITVIVLNIHYRAPSTHIMQPWVRRVFLEILPPLLYMKRPQRYPSKVNKNTQRDPNYFELKEVVHKDADSTRSNGRDIYDNHHPGFKLRTLSDDVAGSDGESTKSSGGTRYSKEFKQAVDGVRFIATHFKTEEDYSRMTDDWKYVATVIDRIFLWVFLICVICGTSGIILSAPLIFEEVKEQQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQK4</accession>
    <name>A0A8B7ZQK4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107347.1">
        <property type="nucleotide sequence ID" value="XM_022251655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQK4"/>
    <dbReference type="GeneID" id="110988293"/>
    <dbReference type="KEGG" id="aplc:110988293"/>
    <dbReference type="OMA" id="ACCKADQ"/>
    <dbReference type="OrthoDB" id="206053at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000066">
        <property type="entry name" value="Putative ubiquitin-like modifier-activating enzyme 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="50"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022107347.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="44015" checksum="89DE10330C0F0930" modified="2022-01-19" version="1">MATVGDLKEKIAQLEAELAREREKSGLGNVLGGRQKIDQMSAEVVDSNPYSRLMALKRMGIVDNYERIREFTVAVVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGMSKVEAAERTLRDINPDVQFETHNYNITTMDNFQHFLDRISHGNLNRDGSVDLVLSCVDNFEARMAINTACNELGQNWFESGVSENAVSGHIQLVKPGETACFACAPPLVVAENIDEKTLKREGVCAASLPTTMGVVAGLLVQNTLKYLLGFGSVTHYLGYSALQDFFPTMSMKPNSACDDSFCRKRQKEFRKEEALKPKLEEAVKEAEIVHESNEWGISLVDESSIDDLKTKAAPELASGLSYAYDRPDETTKDSDEVVTDTNQSLEELMAQMKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQS2</accession>
    <name>A0A8B7ZQS2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adhesion G-protein coupled receptor G4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988497</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107754.1">
        <property type="nucleotide sequence ID" value="XM_022252062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQS2"/>
    <dbReference type="GeneID" id="110988497"/>
    <dbReference type="KEGG" id="aplc:110988497"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="836"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="871"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="903"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="945"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="990"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="7">
        <location>
            <begin position="650"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="8">
        <location>
            <begin position="832"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022107754.1"/>
        </source>
    </evidence>
    <sequence length="1125" mass="122379" checksum="221358C0CFAE3D96" modified="2022-01-19" version="1">MDFHLSAIFVSTDVASLPSPLRGHHFVFEIDTELDHHSDAHHRERRRSGRGEALDTWDCDNVTVVPNDIRTSFPLNEFYQKYMHAYGIPILSSNISQDVSLMRACYVVRFLLADRKDLRDAMYDRYGRVAVIAKTERTTQIPEHSYLNSNLWDSRARGLGGFPQVPVTTNAEENLLCEDIASDPWFEEDVLVHEFAHAIHLISLDRADPSFDARLQTIYNMAKAENLWRDTYAIVKRTEYFAEGVQGFFNVQTCSSFVDGVHNHVCTREALRGYDSRLYNLITEVFPCMNTIVDRCNSTQSLAANQELRMNCEIVTTTTTTAEGPTTTPTDLTTTAATTVLTTSVASTTTPRTTSVPLTTSAPFTTSVPLTTSAPFTTSVPLTTSAPFTTSVPLTTSAPFTTLFTDTTTDSGATENFTGSVSVTTQLSSTSHATTAPDKFCEEGTTFDIDAGVLTWPVTAAGTRSQSIEVCALETQKAGSPIALRNCSTVVGSLLHPEWEEQWEIQDCGTSKDRNDISVKDLTNVTVSTGNAVEVAQFLANLTGNFKRARVRPILGDVSEVFQNIIAAESGDAKVTEAMSKTVDDVVIGLSSGQLKGGDDPKSRSIIVESFQAQVARTLRQAGNVSLRQESVQVEAVSISRSEAVMSGLSFASVRPGGTGGASATEKVPLNETRIQTFLGQNGSANGVVSVQLPGSELDQAHDGGNSGQLRASFIVYGDDTLFPSARTAGTQNAGPTVGGFVIAVTLQDLVLRDLANPAVIQFKAPSNGDTKTMKQTRCVFWDFTLRNGTGDWSEEGCALNEATNDVIECHCDHLTNFAILIEEVIGSSQALHVSSQIGCALCIAFLAITLLASLCLDNSKGSQKGSTSRLLFYQLCVSLLVLYVVFLAGVDGAKGSNGGCMFVAAFLHYLVLVVTVMMVIYAVDLYLATSKKIPRDNAPKFHTTYAVLVACGFPMIVIAITVPSAMEYYKINSDVMNSGPTYCFLKPGLAMYLGLLLPVCIFLALNATVFLLVWRRLPRADKRLHSAQTSQRLQEAVGISLLTFLTWLFGILAITSAAIAYDIVFLIASTLQGLFVFIMFCIRRKEVRAAISTHLRCSCLKGSNQKQKYELGQKNVQLDTKLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRV3</accession>
    <name>A0A8B7ZRV3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family. USP14/UBP6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022107797.1">
        <property type="nucleotide sequence ID" value="XM_022252105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRV3"/>
    <dbReference type="GeneID" id="110988516"/>
    <dbReference type="KEGG" id="aplc:110988516"/>
    <dbReference type="CTD" id="9097"/>
    <dbReference type="OMA" id="FKSDAEY"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000032">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="104"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022107797.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="56092" checksum="92EC004EE1BB116D" modified="2022-01-19" version="1">MASCKVNIKWGKEKFSDIECCVDESPDVFKAQIFALTGVQPERQKVMLKGATLKESWTGFKVKDGVTFLVMGSAEALPEAPTQKTLFVEDMTDEQLATAFELSAGLKNLGNTCYLNSTVQCLRSIPELRESLKKYDGHVNQAMASVQPAESITAAMRDLFDAMEKATDGIPPIFLLHLLHIAFPQFAEKNEHGVFQQQDANECWVQLVRLLQQQLTVSVAGENQQAEGASASQKGFIDQYLGGRFDCSLKCVEAPEEEESKSTEQFMQLSCFISQDVKYLHTGLKNRLTENIEKFSPSLERNAQYIKESRISRLPAYLPIQMVRFYYKEKEAINAKILKDVKFPLILDVFDLCTKELQEKLIPIRAKFKEMEDRKVEELQKAKQTEKKQPAPAVEQSIKLLPYDFSDDIGSNNSGYYELQAVLTHQGRSSSSGHYVGWVKKKGEEWIKFDDDSVSPVASEDVLKLSGGGDWHCAYVLLYGPRRLDEPAQDEEPMSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSU8</accession>
    <name>A0A8B7ZSU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110987772</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110987772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106531.1">
        <property type="nucleotide sequence ID" value="XM_022250839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSU8"/>
    <dbReference type="GeneID" id="110987772"/>
    <dbReference type="KEGG" id="aplc:110987772"/>
    <dbReference type="OrthoDB" id="10383870at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034474211" evidence="3">
        <location>
            <begin position="22"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022106531.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="54275" checksum="7756D55B62725CEB" modified="2022-01-19" version="1">MGVIYRFSLLVFGACLAVVAGRNGVGPPRPVASLNDQHQYICSLLPNCTTWCSDCTDRMAMNLFDFLNNCDEWKNAPATGYQHVFRCRPSSSYVACICTTEDPNCRRCEYSVQNNLVCFSQENGDIHVWPFSEDVAVTSVLLEDMCPTCSCSTKWPTTPKLPTTTIEPLSTFHSVEPSMITVAGRTVILNKTASTAEDATPPYIVISPTITAAGVIVIIFLLNVVRKWRRKQRILRVQRPTNSRAETTNRVAESVSHQVNLFGVDIDGSNTLPLGTLLITSFLMPVEGTDPDISNHDYECPDAVLARHHRVVHDYLELHGNTSSQTNNSVHYYASDSNLPAGPPMVHTAPPNDDSTIFGYDDVFASDGGQESLGLVKPDRDTPEPTGDSHDYAEVTSDFPLNPKSTPAGSQKSLGPVKPVLDPPIFTEFVYDYAGVQSDPHPSPEAGLEAGEKSPGRPDRGPTISNEDVHDYAEVPSNPNPDPESPSEGGCKSSTAGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZT48</accession>
    <name>A0A8B7ZT48_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NLR family CARD domain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110988608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108000.1">
        <property type="nucleotide sequence ID" value="XM_022252308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZT48"/>
    <dbReference type="GeneID" id="110988608"/>
    <dbReference type="KEGG" id="aplc:110988608"/>
    <dbReference type="OMA" id="RARIDFT"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="193"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="6">
        <location>
            <begin position="385"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022108000.1"/>
        </source>
    </evidence>
    <sequence length="1208" mass="135414" checksum="B34C0740455DE3B0" modified="2022-01-19" version="1">MEQVSLGQWDKDRITTGAVCDHPRAKLISKKMKAKHGRKAAFLSVFPIKASSRLTDDDKELVPHPKRASTPQCELSKPPNHDQTITKAETESLHERKEKLQVFVRGSFLSRTLCLQLDQKTSVSSLKELIKNKSGIQPQTQHLFIQRNLLLCDSLSLTDQGIQQDQNIEIRAGGLLGGAPEKEQFASGYFLELSEKLGRDWVSLAINLDFDNTQVEQFEEGHKGNIVRQSLKMLDKWYKKQDNPEEAPQTLKNALRKTHRADLASKVPGVAGEHFDVEQCAEELTAHYQQTLKVTTHPTKRGTSVEIGRLYVNQQLLEETNLAAPSCSSEFKIHPAATMKVGHLKGKSQRGTPGRSVSKVEEETGFLFQNVPLDSYEDMLTLKTNRILATAEAGYGKTTLLKKIVYDWVEIKTNGTQQTNQSQPGTKFGLKDYKLVFLIEVNRMGKNFDVVDAIFSQILTEGRFEKEDLEKYIRNNQKSVLILLDGADEISLQRLTHTKQRKDEINLSDMLSFKSLKSCKIVVTSRQKTANELLTMHEHFTKVHVAGFDEKDREKYVGKYLTDFSKQSQKSFLDTVNASNTFRSLAEIPLFLWLMCFTWAEEGKLPHQITKLFSHKIEHLFQRVDSKETDSQANTYAHDTKTDIFALGRLALEGLLDPDGPKLYFMASEINREDSDIFEKGCKIGLLSKTETVYGLTSVTLFSFLHKTFQEYCAAVYLDSLSRSDKKEFHNVLSSIFSGDVESVEFLLRFCCGLNKNTAQTIIREIDGLLGQDKMKESLHRISTLLLFEAQLDSLVDEIVGTGNIKFTFEIQGEDLVAAHYLVQTGSKRKALDINSVKAKCDSLEHLKLLKDIVKEIECNISLTLNLANVHWSNFVDDSQGMIKHMKRLDVRTGDWNILQLFDMLSYKESKISTLVIKNTISFELLSEQMVTPGPIMSLTVLALADTGMKSKDIESLLSLLSSAGSIKTVLLKDNDLHGLQAVKISPIPSLCELQLHECSLTKTDIEPIFSLLAAAASIKTLVLKGNDLHGLQPDQITSVPSLRELYLYECNLTKSDIEQVFSLLAATGNIQVVVLNENDLQRLQPAKITPLPSLCELHLYECNLSYSEIGPLFSLLTGAGSIKKVFLKGNNLRGLEPVKIEPAPLLSDLQLQECGLTNSDIKPLFSLLKAAGSVETVALSGCSFRRFQVDKFTPVSSCVHYSCTNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTQ1</accession>
    <name>A0A8B7ZTQ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110988853</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108452.1">
        <property type="nucleotide sequence ID" value="XM_022252760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTQ1"/>
    <dbReference type="GeneID" id="110988853"/>
    <dbReference type="KEGG" id="aplc:110988853"/>
    <dbReference type="OMA" id="SIQFTHE"/>
    <dbReference type="OrthoDB" id="10018421at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF11">
        <property type="entry name" value="GIY-YIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108452.1"/>
        </source>
    </evidence>
    <sequence length="168" mass="19619" checksum="0ECA75C86322D52F" modified="2022-01-19" version="1">MGSPLSPVLADLFMEEFEQTALFSADLKPSVWIRYVDDTFVVWPHSPQDLQLFLQHLNSQHNDIQFTMEKEQHGRIAFLDVEVSRLPDGTLSRTVYRKPTHTDRYLNNWSFHHPSIKASVNRTLVRRAYNICDQDHLEPELHHISTALQRKNTGFTISDIWRPILNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV73</accession>
    <name>A0A8B7ZV73_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ammonium transporter Rh type B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107421.1">
        <property type="nucleotide sequence ID" value="XM_022251729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV73"/>
    <dbReference type="GeneID" id="110988338"/>
    <dbReference type="KEGG" id="aplc:110988338"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000012">
        <property type="entry name" value="Rh type C glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF60">
        <property type="entry name" value="RH50, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="8">
        <location>
            <begin position="82"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022107421.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="56059" checksum="2278280AFBA17A47" modified="2022-01-19" version="1">MTERSVSDQASSFQPLRNGVSPRPNRKMAWTRGKLTLLLLVLQVVFLVLFGVLVEYDPSADARKKSGGHGEAEGENLAGFSNQVDLYYPMFQDVHVMMFIGFGFLMTFLKKYGYGSAGFNFLIAAFVLEWATLMRGFLELAVKGEDKIHVNIQSMLTADFTSAVVLISFGAVLGKTSPVQLIVMAFFEVVLALVNEHIGLEIFGTVDVGGSMFVHVFGAYFGLAVARVLARDATEDNENEGATYHSDIFSLIGTIFLWLFWPSFNSALALEDARHRAVLNTYFSLAACCVVTFAITTLLNKDGKVEMVHIQNATLAGGVAVGTSADLMIQPWGAILIGIVAAMLSTVGYKYIQPFLASKLKLHDTCGVHNLHGMPGILAAFAGAIAAATATKERYGDNLYKIFEARATNGSMNTAEDFTGGMSHVMESPRSASGQAGYQLAALAVTLAIAIVGGVITGLIMKIPIWNEPEDDELYEDKPFWDVSTIDKSEVEYHEVSTGDIPMKKYAKDGNNAEAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWJ6</accession>
    <name>A0A8B7ZWJ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate sulfotransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107906.1">
        <property type="nucleotide sequence ID" value="XM_022252214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWJ6"/>
    <dbReference type="GeneID" id="110988559"/>
    <dbReference type="KEGG" id="aplc:110988559"/>
    <dbReference type="OMA" id="ALDWCAN"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13469">
        <property type="entry name" value="Sulfotransfer_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107906.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36367" checksum="FD28435B38819847" modified="2022-01-19" version="1">MIETKTTFERHSSASAKPTNHSLIRPHFSDVHRLRKILPVRNTSLPASESQEVHAVVKAQRSQLIIVSQKRSGSSFVGEIFNQHRDVFYVSEPLKSLTTLFKRDKGSFDTAAHDVLNATLQCDFQRIPVAGWVIERSSVNTCSHVQEDTVSLRLGCKEAKSRYCDQPYLKVSADKCRIRKHLAIKTIRVNDLGQLKSFFTTGKLNVTALHLVRDPRGVMNSRRLLGEANLDFLRRKGIHGDETLDLCQHMERNVAFAQHGPEWLQDNYILVRYEDMAEQPHKITAEIYRHLGWEMSEAITKWLEANTNHNAGGEQETEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYX9</accession>
    <name>A0A8B7ZYX9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neuroguidin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAS10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108786.1">
        <property type="nucleotide sequence ID" value="XM_022253094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYX9"/>
    <dbReference type="GeneID" id="110989027"/>
    <dbReference type="KEGG" id="aplc:110989027"/>
    <dbReference type="CTD" id="25983"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108786.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40320" checksum="DCCD30FFE8DB6580" modified="2022-01-19" version="1">MPTVASLPSIVGPAQLQLRGPVCMCQSHCQVMKCNFQINYVKCEHMVTEQDISKLLSFLKGLSDQVSDVSSSIQSLLKKVDSGEISTSKGITFLEVKYHLLLSYLMNLTYVMLQKTEGRKLSGCPAVDRLVEMRTVLERMRPIDQKLQYQVDKLVKTALTGAIAENDPLRYRPNPANLRSKLEEEENQDESSEEEEEEAKPKKYVPPKVVAMHYDGDETVKQRQEKQLEKAKKRALSSALMQELKGEYFDGPEEVREGVNLHRLKEDKEARHKIEYEEDYFVRLPVTRKEKQAQRRLATTSSLKSLTRFDDITALDQTREDMPAKKKRKLPSKLRKKLQKSAAKKRKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZ73</accession>
    <name>A0A8B7ZZ73_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110823.1">
        <property type="nucleotide sequence ID" value="XM_022255131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZ73"/>
    <dbReference type="GeneID" id="110990240"/>
    <dbReference type="KEGG" id="aplc:110990240"/>
    <dbReference type="OrthoDB" id="10066203at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022110823.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="21002" checksum="05E967AED222B0C3" modified="2022-01-19" version="1">MEVRNAKDAPKIDESTRENCLDKEKEKVLRYIAGYVPFALLKKLKKYSNTAAIAFCKFLNSWEVAGSGYSKTFLDSIELVSRVFLTHKNLVKMQGVNIKAVLANRMFTNKLVQDYWSNLIRDKLNADSSKKLFDMVVNFYIKIRCKPFIKVYLNIKKMNSKSISKKAEKALRKNLDEDKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZY5</accession>
    <name>A0A8B7ZZY5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990390</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111068.1">
        <property type="nucleotide sequence ID" value="XM_022255376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZY5"/>
    <dbReference type="GeneID" id="110990390"/>
    <dbReference type="KEGG" id="aplc:110990390"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111068.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17757" checksum="35DE316EEC94C054" modified="2022-01-19" version="1">MSNYGQNMENEDILPELLADSDSDMSSFDSSDASGMGDGEDDFSAAAKPHYRRGWSKAGPSWRKHGKTAPEFTGHTEATHSEEWIDFTPVQIFQLFFLQVVWELLVSREEWRCRTCAQEHPLYARRCTALSRQNYKAQLCCLQYQSSEKANPHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0T5</accession>
    <name>A0A8B8A0T5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990598</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111368.1">
        <property type="nucleotide sequence ID" value="XM_022255676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0T5"/>
    <dbReference type="GeneID" id="110990598"/>
    <dbReference type="KEGG" id="aplc:110990598"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111368.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="34611" checksum="C2B80F50E7DA7F6D" modified="2022-01-19" version="1">MTPVLSGNGVGDFFRLPLAAADPQPVGGRLGNFSRFWWEITADSWVLSTIALGYSLEFTNSPPSGMVFRSTPPPCDKLKFWRRLQHCYTKEPSHWCIRTSYPPASFRLFPRTQKRPGKMATNNQPETAQQVHQAKGVLNGDSEHGPTLSTYSVLGHLNRSTDALPQRSKFCHFSHPRGHDTSRVPHQLRQVGPRSITTADLPGGSSRSSQRCCDSVTGTHPKSAIMCPFVPALQGSSGAGLAPLPSQIYGQPRQPCSLVSTANAATSTSSPVSVSPQDRSDFYLDEEYHKVLVVLQRCLLGGHLPGDLLEISFHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A113</accession>
    <name>A0A8B8A113_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Very low-density lipoprotein receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110990375</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111041.1">
        <property type="nucleotide sequence ID" value="XM_022255349.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111042.1">
        <property type="nucleotide sequence ID" value="XM_022255350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A113"/>
    <dbReference type="GeneID" id="110990375"/>
    <dbReference type="KEGG" id="aplc:110990375"/>
    <dbReference type="OMA" id="VDEMICK"/>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005041">
        <property type="term" value="F:low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF5">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665782" evidence="11">
        <location>
            <begin position="23"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022111041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022111042.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20360" checksum="3DE2C9226C2D82B2" modified="2022-01-19" version="1">MQAPSLLFSLLFGALLIGLCMSHPPKVQQQRHQLRQGCSSDEFACNDGSCIPDYWKCDQWDDCSGGEDEAGCPCRSDQFTCNDGSCIPGSWKCDQWLDCSEGEDEDGCAVPPHPGNCPGYQFQCFFSYDCVDYTDLCDGEDDCSAGEDELFCDIFGGWKRATKTGWKKMARRVGHWKKAQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1P8</accession>
    <name>A0A8B8A1P8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 40-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110989593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109786.1">
        <property type="nucleotide sequence ID" value="XM_022254094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1P8"/>
    <dbReference type="GeneID" id="110989593"/>
    <dbReference type="KEGG" id="aplc:110989593"/>
    <dbReference type="OMA" id="MSEACTH"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109786.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="50627" checksum="7AC89E7097AC8CC5" modified="2022-01-19" version="1">MKVRRMATADDHQAQGVKADDSAYEGFFATTDLQPREVERRKQDQNWDILQSEGKISSKTLSLSNCDLKQLPREVLHMTELSRLYLTYNDLGELPDVFFKLKNLTILNLGFNIFRHIPPVIFELKNLVVLVMKNNGVTHDRIGKGISRLTNLEEIYLDNNKLEAFPEKLCDLPRLRILQLSNNAICKIPDRISKMKKLQYLNMRSNRLTVVPKTVGELQSLEMACFAQNMIHTFPFEKVEKLKRLRDLCLYANRLKDRDKIEQCMHLLAKQEGMLRAEENRCYLPRLGGVCDGPFKVWQQDILWIRDNDVKVVAWVHDMAERLEDNHVISKKCKPNRSALPTLMRNSRIVCVVCTKQMFKRLEGDEDPADAIRRYLSQSPEHTIMTVAYEATGIHTLLMPDGRPNFHLQRTSDDDGDKALFCKLLDHVKNAPRIRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3E3</accession>
    <name>A0A8B8A3E3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110989978 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110406.1">
        <property type="nucleotide sequence ID" value="XM_022254714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3E3"/>
    <dbReference type="GeneID" id="110989978"/>
    <dbReference type="KEGG" id="aplc:110989978"/>
    <dbReference type="OMA" id="KKLFYVY"/>
    <dbReference type="OrthoDB" id="9999810at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022110406.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27700" checksum="A2C5F529FC2FA9A8" modified="2022-01-19" version="1">MGTGAGKNPQVGMPLSPTVEYAEKRSKKEGEPVVIDAPALVDLVHGTVRYRNDGDHIIKAGEELKTGYFYHARLEDYSEAATIKPDDQHKFKYVYKGTNSSRGKQLFYVYGIGFNSKDDRFRVRKQYKPKGRGYIWPSSFRKGNHFYYDLAFITQEHDFSESEDEDEDMKADVNPDNMRFCLKDTDTVEVLKKRAAVRLLVPSSNIHISYRDAELGDETIIGKQRTEEDGDFTRFSICLQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3R4</accession>
    <name>A0A8B8A3R4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein PTHB1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110991129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022112017.1">
        <property type="nucleotide sequence ID" value="XM_022256325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3R4"/>
    <dbReference type="GeneID" id="110991129"/>
    <dbReference type="KEGG" id="aplc:110991129"/>
    <dbReference type="CTD" id="27241"/>
    <dbReference type="OMA" id="VPVEDWT"/>
    <dbReference type="OrthoDB" id="10262646at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028074">
        <property type="entry name" value="PHTB1_GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028073">
        <property type="entry name" value="PHTB1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026511">
        <property type="entry name" value="PTHB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055364">
        <property type="entry name" value="PTHB1_CtH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055363">
        <property type="entry name" value="PTHB1_hp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055362">
        <property type="entry name" value="PTHB1_pf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991">
        <property type="entry name" value="PARATHYROID HORMONE-RESPONSIVE B1 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20991:SF0">
        <property type="entry name" value="PROTEIN PTHB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14727">
        <property type="entry name" value="PHTB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23339">
        <property type="entry name" value="PTHB1_CtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14728">
        <property type="entry name" value="PTHB1_GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23338">
        <property type="entry name" value="PTHB1_hp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23337">
        <property type="entry name" value="PTHB1_pf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTHB1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 GAE" evidence="3">
        <location>
            <begin position="444"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 platform" evidence="4">
        <location>
            <begin position="534"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 hairpin" evidence="5">
        <location>
            <begin position="644"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="PTHB1 C-terminal helix bundle" evidence="6">
        <location>
            <begin position="748"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="884"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="926"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="950"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022112017.1"/>
        </source>
    </evidence>
    <sequence length="1007" mass="110193" checksum="CB1E46BBC974A89F" modified="2022-01-19" version="1">MSLFKARDWWSHTIGAEDGFDGGSLCVANIDNSSTHLDKVIVGGFNGVLRIYQPRGSQGEANKAAAVLLEMQLSQPILQVEAGRFVSVSENLHLAVLHPRKLTIYSVSGTAGAVEHGSQYQMKMVYEHNLQRTAFNLVVGPFGSVKGKDFMCVQSMDGTVSFFEQESFSFSRFLPGFLLPGPLKYIPRTDSFITVSSSWQVESYKYQVLAVATDAKTKEESQKITSGKRITMDWSYNLGEAALDIFVTVSTQGATSILILGERSVICLKDTGAFKFMKKLEYTPSCLFPHGTSSDTSITYMVATHTGQLMIYQDTTLKWAAKLEYVPVSIRVGQFQDLKGVITSIDDQGHLVCSYLGTDPSLFVTPSTDSREINYEEQDLEMRKLQRVIKESASKQDFRPKKTADEDLQIEVTVPPNLDSTSVYKYFTEGVRSATETEVEDEDPIPSITVKLVLKTSVSLPNVRLLIHCPYPISPNQSTFTFPFIGDSSAPTSVLVSFFLRGNSLPASLTASAMATYSTSKGAPRVVKSAIELPLKLVVKPCAPVKTATYKITVDSNRNAANLNEVFPDLLGPNAGGPGQALGFQIIGGPKVTILASKSSQRYRLQSDVFESMWVVLRSFIDRIQSFQRRGGAKDFQLSYSGIVPLTEYFELIDTHLELRINAERYKELLDQRARQFRAIQRRLLTRFKDKTPSPLANLDTLLDGTYRQILKLADGVEENHKALVRCSLGLSCATHIIVTVIKLAHSLTDKEFDILKSSLMPHVPCDGEQGWEEAVDAGISNLLRTCLAKKALDQAVNPSPLTMPADTTKLKKHITQLCERLSKGVRLYVAGQAPEKRVEKNEGVVRPSSSTSRDFNVDSKTPDQSKRLDFHKTSQSSGTVIPQPNPSPAPHADPQPLPVSLPPGVDDLPSPGPETNGTLDKEEVPSPGSGSLLGDLPSLGGPGVRGTSLPPLGGLGVEPPSALPQLKPIKKKKKKKTKSPRSAEPELEPDDNFFGGSGSPEPLSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A4F8</accession>
    <name>A0A8B8A4F8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Semaphorin-2A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110811.1">
        <property type="nucleotide sequence ID" value="XM_022255119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A4F8"/>
    <dbReference type="GeneID" id="110990231"/>
    <dbReference type="KEGG" id="aplc:110990231"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF127">
        <property type="entry name" value="SEMAPHORIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110811.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15569" checksum="CEB8F5838D3A0DB5" modified="2022-01-19" version="1">MEVAGKPTRPAISKSVLQSDSSQNVMSISVTLMSKDDVNVLNGPQFVGDPISYNGRVYFFYREVASEFIEGKAVYSRVAVICENDKGGREFTALKPTDIVTFVKARLECSTGTTFPYFYNEIRDIYHSNGVVFAVFATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGN2</accession>
    <name>A0A8B7XGN2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Cytochrome c-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC110973420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079948.1">
        <property type="nucleotide sequence ID" value="XM_022224256.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079950.1">
        <property type="nucleotide sequence ID" value="XM_022224258.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079951.1">
        <property type="nucleotide sequence ID" value="XM_022224259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGN2"/>
    <dbReference type="GeneID" id="110973420"/>
    <dbReference type="KEGG" id="aplc:110973420"/>
    <dbReference type="OMA" id="NKGVIWG"/>
    <dbReference type="OrthoDB" id="283091at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 8 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="11">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022079948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022079950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022079951.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12875" checksum="AC3DFCD06D6B7A24" modified="2022-01-19" version="1">MSKAEIKPGDPAKGAAIFKQKCTQCHVIDKTGKHKQGPNLMGLWGRRTGQAPGFSYTDANKNKGVTWERETLFTYLENPKKYIPGTKMVFAGLKKKKEREDLISYLEAATQGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGY3</accession>
    <name>A0A8B7XGY3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Muscarinic acetylcholine receptor M5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110973134</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079381.1">
        <property type="nucleotide sequence ID" value="XM_022223689.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079382.1">
        <property type="nucleotide sequence ID" value="XM_022223690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGY3"/>
    <dbReference type="GeneID" id="110973134"/>
    <dbReference type="KEGG" id="aplc:110973134"/>
    <dbReference type="OMA" id="EREQNTH"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF195">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="49"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022079381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022079382.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="50158" checksum="B5CEE9A9B117F087" modified="2022-01-19" version="1">MDAFVNGSHMIMNNSNLNVCSEETPVFCLSRTVSVSIVLGIIAVVTVIGNIFVIVAYTKDKRISSTVANTFILSLSISDLIVGAVSIPLNSIWVVLGDWPFGKIPCQIWLVLDYASTNVAVITILFISLDRYWLLTKKLAYGTFQTHKRAAVMIIASWITTTLFYTLITFLWGPLTGVYKVDYDKDCELEPYDNLSFLGFTMAAEFFIPLLIITYFNAQVYINIKRRSKGVFQKSRHSQKISTKDPSTSVGSHYQRKPPEQRLDEQRLSVGHRHQLPEKLHSPRLEEEEGHSNSAFDGHLEGITIRLHSDQSQLPAENREANSDERHTRATIKETPNCETAKQSSGVDQDHRFKRREFKRHRKAAVTLSVLVGVFIVSWLPFYIASLLAPFCEDCVSDLAWEVVNYLLWCNSTVNPFLYALLVVRFRQNFLRYLGLRSCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XH17</accession>
    <name>A0A8B7XH17_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LIM domain only protein 7-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110973191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079511.1">
        <property type="nucleotide sequence ID" value="XM_022223819.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973191"/>
    <dbReference type="KEGG" id="aplc:110973191"/>
    <dbReference type="OrthoDB" id="15627at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21208">
        <property type="entry name" value="CH_LMO7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00136">
        <property type="entry name" value="PDZ_canonical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000038">
        <property type="entry name" value="LIM and calponin homology domains-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029978">
        <property type="entry name" value="LMO-7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46767:SF2">
        <property type="entry name" value="LIM DOMAIN 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46767">
        <property type="entry name" value="LIM DOMAIN ONLY PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="23"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="609"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="1806"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="344"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="431"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="702"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="767"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="953"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1170"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1210"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1248"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1520"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1655"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="709"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="843"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="894"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1016"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1248"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1305"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1405"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1533"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1559"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1669"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022079511.1"/>
        </source>
    </evidence>
    <sequence length="1877" mass="215554" checksum="628ACEA76E7F40BB" modified="2022-01-19" version="1">MMDGDSDSERSASLRHQDQTSLEDALVEARKWIENVTRKKFQSDDFRRSMTDGILLCMLMQKIRPGLIKKINQSRSIYAGVDNLNVFLGACEDLGLKAAQLFHPGDLQDLSSRASLSVHDRRKEEERRLKSVCITIFWLGRTANQLDTFTGPQLNLDAFAPLIHGSSSLVKGLSPDNASSGVSSWASGGSLNNNLRTSLGYNDDVFTSDGIDLTAIAPEKYSEPKWKRDLKKELDSSVPGLSEYADHANSRPILRMDTSRRRPPPVAAKPLHSRSKSMPERSTLERQNSVEDEDSQSYRSGSSGDPTSPTTYDEFVKSKGLVQEDQEMWMSMADAGSTVLSVQRSLDSWKSRRRRATHSALERKASREEVEQQELSKQRRRSKTYQEMMEEKEKREKILMKMASKNKSLDAEDIVHILTKPALYEEEIRDVPERRTRSKSIPGNFKQGESMPSMFDATNPTYSVDSTDAPSLSRQPPPDVFPKPKVRRSGVGSAFAPYQRTNSRESNKGSRTVLSSQRVDDFTNLRPGHVEPMTFREKLLRDREREIGLSAVQRDSKSSARLPQKKRLSLGIMGRVAAFNKGETEVETQPKLQPPRPAPKPEPEYMALTINMKQKPRNENGFGFTIFGGADSKRPIVVTSITPGSTADKNELRVGDEIIAINGETTKMVTYDHALYCFSSSVLDGELTLKVHRYEDLGKRVRSTSGTRSTEHTTAKSDTSEFAKRRAFSQPSDPKNLSQAARARKILQQMRDEEQRMEDLRWEREEERMGATVNGNQNWNHSDNKQGPLRAYYDEPEPEERPLGDAIPSGPAASSVSEPADSVPFKNWEDTQMSPNHTSFIEPEIKQDVVKPVEKPDPFSNLERNSPSREEYGESAQISIEVKGDEISPKRDTISPNTGIVSDNLTEDVDGKYPYDGVINLKPKVEGDRIEPVETVVKTEVAKEQSVNLLKLLGHDALETPQSGPLAKDGNRPEETGPDGGIIDDPPDRKTNKSKPHSHWINNLERLTMTVHEIESDGDMFSSEDDERMEEEIMNKMQEEQRAEEEAEARHRRIEEDEQDKLPVEEDFITSRSKLTEEAPISKQQHTSEESAPPLLPWQRSGDSGKMPKFQPVKFSAGPRPFSNRQGPEPYKPPSFKPVSVKDSAPDVKQDMLKRRSDFFSKPPEIGLLPVFGYSDDERDRDNRSGTSSPVIGASVTAEVQEPTEALIELQAQEPVESVAKPPPKQPLSLASRKAFNVEEERKRLERWHAEQERIRQEQYEQEQRRLREQQEKDLERAESEERRRKMEEQQKLIEKQQILQEQAAEEKRRLEEERKERVKKEQEYLERARLEREAAERERLKDEEEQRKMAAERKRREEERLRKEEEERQRKGAERRKAEEEEQRQREEEERHQRELEQLEQEAEERRIAINKLREKEAEERARRKKEEEARLAREQQEKEKERFARLREEEIERIRREEREKLRKEWEELQREKAKQEERERAERERLEQLRAEQERLRQERIKLEKQQEEERLQLLREKERLLEQSTSTKLDADKIPYNKQDRDRGSKSPDVIGKNNRSEEHEVPVKEEIIVSQEETDVHSAPPSKPHDSFKVPGQGYMSQFKDGRMATQHWMVEEAERRRLAEKTGTTRLHDPVEVHNDPILRKDLDMEPVLEKKNYAPEHVAPVRHMDKPANQEPVGKTRDHNRQPPPSSQNSQNQTYRELAVDVPPDFQPAPRRLRAPEIDAEKKKKIQNRQSMPDMGNRVPDVVRNDAYTPPPPQTSDRNSGRMPDNFLQQPQLGPPGRTSAFQQPSKKPAPGRSVSGKVTCSNCNKSLGRGAAMIIESLGLHFHIECFRCCVCNIQLGNGTQGTDVRIRASKLHCQNCYSNDAGFEFTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHP2</accession>
    <name>A0A8B7XHP2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Steroid 21-hydroxylase</fullName>
            <ecNumber evidence="14">1.14.14.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">21-OHase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Cytochrome P-450c21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytochrome P450 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cytochrome P450 XXI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytochrome P450-C21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24 25 26 27 28 29" type="primary">LOC110973335</name>
    </gene>
    <organism evidence="23 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25 26" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.16" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022079741.1">
        <property type="nucleotide sequence ID" value="XM_022224049.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079742.1">
        <property type="nucleotide sequence ID" value="XM_022224050.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079743.1">
        <property type="nucleotide sequence ID" value="XM_022224051.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079744.1">
        <property type="nucleotide sequence ID" value="XM_022224052.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079746.1">
        <property type="nucleotide sequence ID" value="XM_022224054.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079747.1">
        <property type="nucleotide sequence ID" value="XM_022224055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHP2"/>
    <dbReference type="GeneID" id="110973335"/>
    <dbReference type="KEGG" id="aplc:110973335"/>
    <dbReference type="OMA" id="VDEICMN"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004509">
        <property type="term" value="F:steroid 21-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000049">
        <property type="entry name" value="steroid 21-hydroxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF1">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 21 22" id="KW-0349">Heme</keyword>
    <keyword evidence="10 21 22" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 22" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="21">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022079741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022079742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022079743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022079744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022079746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022079747.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="56208" checksum="C019DF5B6E71D13D" modified="2022-01-19" version="1">MILTACLCGTALCAMYYLKEQYDYTIRRMPPGPPSIPFIGNALSLDPKAPHLSLLELAKKYGDIFSIKLGSQRVVILNTCDVIKEAYKGLDISHRPNIYCMDVLVGDKGFLTCNDTNQWRLHTRLCRSALRIINNSSLGVKISEEADCLINKILDYHGKPFNPCQDLYLASLNVLCNISFGERYSHTDPELHDILDYSAEILKVISPVHPVNALPWLRHFPNKWFERLMKAKEQRDRLLMRKYVQHVATYKDGEIRDMLDAMLASAKQAVQEKDDNSLSVLTPEHIIINMWLMFFAGTDTVANTLQWGLLYMAAFPKKQAKVHDQIEQVLGKDGLLTLNCRARLPYLEATVNEIMRFSSLTTLGVPHAAAVDTKVRGYYIPKGTQVMANFWAVHHDETVWDQPHEFIPERFLDSDGNLRNMSEFPYFMPFSTGQRSCIGKGMAKAELFLLLGKLLHKFCFQLPENAKADLEGLASVSLIPKPYQIRALERAMYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJL0</accession>
    <name>A0A8B7XJL0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Toll-like receptor 2 type-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110974003</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080979.1">
        <property type="nucleotide sequence ID" value="XM_022225287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJL0"/>
    <dbReference type="GeneID" id="110974003"/>
    <dbReference type="KEGG" id="aplc:110974003"/>
    <dbReference type="OMA" id="RVASHTE"/>
    <dbReference type="OrthoDB" id="643377at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF530">
        <property type="entry name" value="MSTPROX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="12">
        <location>
            <begin position="317"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022080979.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="54610" checksum="3BC81C3833541B20" modified="2022-01-19" version="1">MEALREQSSSLLKVDIFDVSTHNRRAIIPPRFDSFEALQTISIEDTTLLPLPNFSFCHLPALLHLKVSNVLLGDQGFPPSVFNDVPRLETLRLSRVGFTEIPAALTHLRTLKRLDLSDNEIENVEARVLSTLRGLQVLDLQGNRIEVLDGAVAATLENMTSLQAFRLDGDNPFLCTCELLPFLVWLHKSSIHIGKKSNFATYACKNPSQLSGARLLSPDLLSYLESNCSRDVTDEPSASPPNTTEESHGGKVADVSLSYQIIIPVAIVSVVLSAVGVVATWMLHKRLKRRWVGLFRRFDPNIVPRQVSNTPDQEMGYRYDAYICHHESATEFVVNEMMPEMEGEPGGFRLCLSFRDFLVGADKVDNVATAMKASRFVIVLLDGEFIACGQCMLELNMACTRTLEAGVCVVPAAPSSEAHHLLPDGATGLLLVLLEALPVEALPTTLRVLQDKITCLEWNREDTRRCWQQLKISLRNTTYYQSPQLERVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKP0</accession>
    <name>A0A8B7XKP0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase lambda</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC110973858</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 24">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with PCNA. Interacts with PAXX; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL. Interacts with XRCC4; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL. Interacts with NHEJ1/XLF; promoting POLL recruitment to double-strand breaks (DSBs) and stimulation of the end-filling activity of POLL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 23">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022080717.1">
        <property type="nucleotide sequence ID" value="XM_022225025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKP0"/>
    <dbReference type="GeneID" id="110973858"/>
    <dbReference type="KEGG" id="aplc:110973858"/>
    <dbReference type="CTD" id="27343"/>
    <dbReference type="OMA" id="KWHGASA"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000031">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000004">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000001">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000020">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001726">
        <property type="entry name" value="TdT/Mu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000817">
        <property type="entry name" value="DNA_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 23 24" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 23 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 23" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19 23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 23" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="27">
        <location>
            <begin position="65"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="170"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="25">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00054974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00061803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR000817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000817-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022080717.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="71455" checksum="CA40F45491A527AC" modified="2022-01-19" version="1">MASPSKVKGSKSSNLKRKQPTINPFLPNEESGGGTAKKFKTSTVIDPSGSSSVKLKPESSNDADNGQQFFSSVVAYILPAGIGKARTDIFKKQMSKFGAEVLNVWDEAICTHLIVDEGMDVERLKRIMKIEKAPSNSLVLRASWLSFCLTEKQLLPTDNHKLRFPMIQKEDMSRKPDASSKPVSNTSQKSETAESCDIKNKTLEKKTDGPKASDVPSTSNAPMSNVQGTKWTSPVKAAGSDRGYDSDDSNYVPSDDDDGQESLMITTVSDATGPSSNVSTPASSPQKLPKGNWVCSKPSTSQQKNLNDHITEKLEVLMKTYANTKDHWRAMGYRKAITALKQYPKEVTSWEEANKIPGIGTRLADKISEILESGHLRKIDHVCGGEDMKALDIFNQIWGVGPTVAQEWVQLGFRTLDDVREKAKLTRQQKIGLKHYEDFLERMPRQEAGEIERTVREMAESATPGMLAVVCGSYRRGKATCGDVDVLITHPDGKSHRGALGKILDGLRAKGFITDDLVRQGEEDDEQKKYMGVCKLPGDNKKQFGEDFPCFIVQYRRLDIIVAPYSQYYCALMHFTGSGHFNRSIRLLAKKKGMSLSEHALRTGVIRHGQVKVHDGTPLPVTCEEDIFRHLGLEYREPEERDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLV6</accession>
    <name>A0A8B7XLV6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein NEDD1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110973985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080950.1">
        <property type="nucleotide sequence ID" value="XM_022225258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLV6"/>
    <dbReference type="GeneID" id="110973985"/>
    <dbReference type="KEGG" id="aplc:110973985"/>
    <dbReference type="OMA" id="GTMVLWD"/>
    <dbReference type="OrthoDB" id="1602884at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052818">
        <property type="entry name" value="NEDD1_Spindle_Assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44414">
        <property type="entry name" value="PROTEIN NEDD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44414:SF1">
        <property type="entry name" value="PROTEIN NEDD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022080950.1"/>
        </source>
    </evidence>
    <sequence length="640" mass="68169" checksum="5547B11BCECA6932" modified="2022-01-19" version="1">MEEGLKLATGGDDIKLWDVAGSSAPLHQFSPHSSGISSISWSHNNQILASAGSQGDKVVLTFVKNAASNIIEIAEDEKQTCVAFNSTSRYLLTGGKNRVVSIWDLKSRKVKKTYMGHQDAVTCTTFNWNDTYVASGSASGEILLHNVVSGQASSPLLAPKLKCIIKSMTVESPLTSISCLHDGATLAVGSTRGKVYIFDLRTGSSPLRVLHGHKSSVQCVQFQHGSTTRSNGVSGKSSKPAQPVGGSQKPPEPTPGVALVNPTIHRGSRTAADSDVSKPPEQTRGSANRPSPKEDIENQDIISPLREGTVPAVKHPEGINHISRPDTVGKAEGTPVQSRDSLPDFFSPLSENTSNISARRNPIGSVELEPQPAFTTPQPVTKGVPKEIRVQNGPDVPSLNAVSPLRTNSSSSQAKPVSKPEFSLDLPAQQAASPRRERSKSLTSPRSPLLGPDFAAVSPGASSGPESEPPRLRNIGLSATAGLGPGRAKASVIASTVEVDAKPVGVSPRRGNSPARGLLGGSADAAARKVVNGDIGVLSRVGPPTSLADPQDDGPRASEGMASLQPFQVQFIKNMIDDSLEEFKESFHREILHLQGEMVRQFQIQQNEMQELLQKYSINEGLLAEIERLREENKNLKAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMB3</accession>
    <name>A0A8B7XMB3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Coadhesin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110974174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022081302.1">
        <property type="nucleotide sequence ID" value="XM_022225610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMB3"/>
    <dbReference type="GeneID" id="110974174"/>
    <dbReference type="KEGG" id="aplc:110974174"/>
    <dbReference type="OMA" id="RTRCSTH"/>
    <dbReference type="OrthoDB" id="6273859at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000067">
        <property type="entry name" value="Hemicentin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF21">
        <property type="entry name" value="SEMA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034781725" evidence="8">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022081302.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="27269" checksum="27909FDE01D57F90" modified="2022-01-19" version="1">MDFMRGRFLRLPVTLLTVMVVAAAPGNFVSAAPLSTQTEYTIAVATNGSETETGVEGGGLPCNDTACQGELSAGDTGLPCNNTACQAVNGSWSEWGEWQNCSASCGTGNMTRYRTCNNPAPLYGGTPCNGTSEESYPCDTNISCPSVDGGWSEWSDWSACSVTCGGGGRTSRSRICNNPVPMHGGLDCVGDGDEIRPCPSPICPAPQSHWNQWGAWGECQANQNCSPSYQIRQRQCPGNDCPGVSVQLRLCTINTTGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRM2</accession>
    <name>A0A8B7XRM2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NACHT, LRR and PYD domains-containing protein 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110975361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083494.1">
        <property type="nucleotide sequence ID" value="XM_022227802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRM2"/>
    <dbReference type="GeneID" id="110975361"/>
    <dbReference type="KEGG" id="aplc:110975361"/>
    <dbReference type="OMA" id="QCDLTAG"/>
    <dbReference type="OrthoDB" id="5855206at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="194"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022083494.1"/>
        </source>
    </evidence>
    <sequence length="962" mass="107598" checksum="CCB82096BB30DCDB" modified="2022-01-19" version="1">MADWDGGESRGEWKRRRHQAPGELDDNTLHSISAQIHAGEWRGLATRLGFSPAEISDFTSHYAYTTDQIYHMLVSWRTKHSDDASQREALSKALWEVGNTYLADELSEHSTSDEQSQDVSDLCEKEMKTHYSKRGSFVKTNPWLGEQKHTSDMYVHTQLLLLSVPQKTKNSLISLEDILLSNRSDGELIPLHIHVAVLSGLAGSGKTTLFDKIASDWAVGCPVLKKYKLVFLLKMFALEQGSDLTDAVFDQLLAEDTKVEKNALWSYIKTNPHQVLLLLDGFDELMTTSLDKSSFGSILKILNGKLCRGCTVLVGTRPSHFERLVTRDLVGEQFAHVSVMGFNKEDMREYVKKFYSDDSDQAEGLLARIQSSNLLSTLAASPMLLLLMCLLWKDHSTLPETMSRLYFKALEYIGKRKNVSKEEMSRAVIALGKVGLLGLLSQGQILSFKENDFEPSVLDMALKAGILTRERVAKVFSLHNNVQFIHKTFQEFTVALYLKDMFETNRETFQKTLYEIMSKGPLGFEYLLRFCCGDNEACTLEIMKAFQERYQEDLSLHKKVGLLVLHCYYESQCTCLPQESFIESFVTNTIAVVLLCTDDLHSYAYFLKCVANQTKDCGNAYLGNVELLQIRSPELITGTCVEDLAYAMSAMTNLHAARFIQCGMTGEDFAHVAESLADLPNLVTLVLNESNLGGTAAMWCKQLQAFKALQDLALSECSLNGQDVVFIAESLSDAPNMVRLNLFGNNLGGTAASWCKYLKQCRTLTNLILGHCSLTGQDMVHFGESLSDLPNLEMLNLPGNDLGGTAALWCEKLKDFKALQDLALFNCSLNGQDVINIMESLIPFPNALALDLSRHNLGDTAASWCQHVKQCKTLQELRLRECSLTGQDMVHVAGSLRDLPNLVGLYLTNNNLGGTAAVWCEQLKKCKALRTLNLHCCELSQKEKILIKKSLRDLKKKGLLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSM2</accession>
    <name>A0A8B7XSM2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prostaglandin reductase 1</fullName>
            <ecNumber evidence="4">1.3.1.48</ecNumber>
            <ecNumber evidence="5">1.3.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">15-oxoprostaglandin 13-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Dithiolethione-inducible gene 1 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leukotriene B4 12-hydroxydehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NAD(P)H-dependent alkenal/one oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="37" type="primary">LOC110975587</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
            <dbReference type="ChEBI" id="CHEBI:133975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:51213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133374"/>
            <dbReference type="ChEBI" id="CHEBI:133409"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="27">
            <dbReference type="Rhea" id="RHEA:50590"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133408"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="32">
            <dbReference type="Rhea" id="RHEA:50586"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50592"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:79072"/>
            <dbReference type="ChEBI" id="CHEBI:133411"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:50594"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>20-hydroxy-leukotriene B4 + NADP(+) = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51208"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57460"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133346"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:51209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>4-hydroxynonanal + NADP(+) = (E)-4-hydroxynon-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58968"/>
            <dbReference type="ChEBI" id="CHEBI:156112"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="28">
            <dbReference type="Rhea" id="RHEA:64738"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>6-trans-leukotriene B4 + NADP(+) = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51204"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:90723"/>
            <dbReference type="ChEBI" id="CHEBI:133974"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:51205"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>an n-alkanal + NADP(+) = an alk-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13737"/>
            <dbReference type="ChEBI" id="CHEBI:12834"/>
            <dbReference type="ChEBI" id="CHEBI:13757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.74"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:13739"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>decanal + NADP(+) = (2E)-decenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31457"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133455"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:50614"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanal + NADP(+) = (2E)-dodecenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27836"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133741"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:50786"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>hexanal + NADP(+) = (E)-hex-2-enal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28913"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88528"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="34">
            <dbReference type="Rhea" id="RHEA:50778"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50608"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57461"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:133309"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:50609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77927"/>
            <dbReference type="ChEBI" id="CHEBI:133457"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="26">
            <dbReference type="Rhea" id="RHEA:50618"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>octanal + NADP(+) = (2E)-octenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61748"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:50782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>pentan-2-one + NADP(+) = (E)-pent-3-en-2-one + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16472"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:145276"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:50790"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer or homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADP-dependent oxidoreductase L4BD family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.48" evidence="4"/>
    <dbReference type="EC" id="1.3.1.74" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022083864.1">
        <property type="nucleotide sequence ID" value="XM_022228172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSM2"/>
    <dbReference type="GeneID" id="110975587"/>
    <dbReference type="KEGG" id="aplc:110975587"/>
    <dbReference type="OMA" id="DKVMGMT"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047522">
        <property type="term" value="F:15-oxoprostaglandin 13-reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006693">
        <property type="term" value="P:prostaglandin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08294">
        <property type="entry name" value="leukotriene_B4_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014190">
        <property type="entry name" value="PTGR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="35">
        <location>
            <begin position="15"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00049179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00049368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="RefSeq" id="XP_022083864.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35561" checksum="15E0C580C001F98A" modified="2022-01-19" version="1">MTKGRKWVLEQHFQGTPKRSDLKIVEFDLPPITDGSVLLEAVYLSVDPYMRPFSASLPKGSTMIGEQVARVTQSKNPKFPVGTNVLVNAGWVSHSVSDGKDLTKIPPYPEGVPLSLALGTLGMPGMTANYGLVDICEAKAGEVVVVSGAAGAVGNIVGQIGKVKGCKVIGFAGSDAKVAWLKELGFDEAFNYKKIKDLGATLKSVAPDGVNCFFDNVGGEFSSTVLENMALFGRIACCGSISTYNNTKPLMLPATHIHLITKQIKMQGFVIFSQRDRYPEWVQRNIQWIKEGKLKYKEHVTKGFDKMFDAFMELFSGENTGKAVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTR0</accession>
    <name>A0A8B7XTR0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110975771</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084238.1">
        <property type="nucleotide sequence ID" value="XM_022228546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTR0"/>
    <dbReference type="GeneID" id="110975771"/>
    <dbReference type="KEGG" id="aplc:110975771"/>
    <dbReference type="OMA" id="GCEGWIS"/>
    <dbReference type="OrthoDB" id="5988469at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029309">
        <property type="entry name" value="CaRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048324">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47456:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15299">
        <property type="entry name" value="ALS2CR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21056">
        <property type="entry name" value="ZSWIM1-3_RNaseH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="798"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084238.1"/>
        </source>
    </evidence>
    <sequence length="1037" mass="117662" checksum="1DE750670DAF999F" modified="2022-01-19" version="1">MEGDGDLVAAAIMAMQQTDSEHDPESTILHVVAQAECPGDGQVENQIMVQSDGEIIVQQHPASALQELQQQGVETAGQQRVQDGAVVGAAAPQDPTTLTVEMHEVTGMDVQTVPITCASEQTNDEAMQQGIGGRFLQESIGPVTPLEVVQEATEVDIQSIDENVTKLCKKYLSDVKEVDKDYLRGFHEGPGISFEEFLSKYFCVTGTSFVAVSNRSRTMPSTGQQRQSRYYGNCEGRIRWEAKGGTLPIEFCGSPFKIESSMYLHCLHGPKRDLRTKEPKPPKSGRRGRPRKTTNKKLECPASIQVREISMYTNECYFVDKKEFKNVSKLRWEKQRILKKIREDEGNGKEVTTVRRLYIKLPYVRVHSSLHPVGENSSVNQTMDYRVSQKLKQLIANNVTNINEIKKCLKHYVDDVLFKHNPLEKKPKPNNRKFYPSPADLQRQIAAALSNTVENADVLAEKIKEWQAKGTGRFMYRPHKADSEQSFLFVHQEKWQQRLMERYGSDLVMLDATSKSNTVLTMATPLYSLCIHTNVNFIVVAVFVVEKETVANIREALGIIRTWNPWWSPSSFMVDKCSTEITAVKEVLPNVRIYISDYHRRQALARWIGRKESGLDAEQQKMVTVQMDKIASEQNQTLYSSAKKELLSSKMVTENEEFQDYLQSEWFSCPEMWAHAYRDYAIDNLINVNNGEVAMERFLHFTSIPKSREKGVGGIVTLIVESYLPDSFNKYRKKNNVWKYSRFPAQAQNVPPDLRDRPAHFVRECLLSQSEAARYSNIDVQLIDATHGVFNVRSKKGFHIASFLGPSCTCSHWRKYRFPCKHFFAIFQHFYEWGFNRLPDLYINSVFLTRDTGVFQDPPADGAGVPQDFQPLEIQVTISGAEACPTETVTVATTSDAGASFAASMPNPIPVNLISIPDLDEGSSSAQDFEPNPDKQAKIMNIFKRGMDLITDICDPQLITETEEVLSHMVTKLQRRVTHDHYMQKALPSIKRLKPNPPPQQPPPQMQPAHDQQQQHQEQQQQQPGQVSLECVSSSYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUJ3</accession>
    <name>A0A8B7XUJ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CD109 antigen-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110975616</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083907.1">
        <property type="nucleotide sequence ID" value="XM_022228215.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975616"/>
    <dbReference type="KEGG" id="aplc:110975616"/>
    <dbReference type="CTD" id="135228"/>
    <dbReference type="OrthoDB" id="9998011at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000001">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036595">
        <property type="entry name" value="A-macroglobulin_rcpt-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050473">
        <property type="entry name" value="A2M/Complement_sys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041813">
        <property type="entry name" value="A2M_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041555">
        <property type="entry name" value="MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412:SF136">
        <property type="entry name" value="CD109 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11412">
        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07677">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17791">
        <property type="entry name" value="MG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01361">
        <property type="entry name" value="A2M_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0882">Thioester bond</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034612314" evidence="9">
        <location>
            <begin position="32"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="10">
        <location>
            <begin position="470"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="11">
        <location>
            <begin position="743"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="12">
        <location>
            <begin position="1373"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022083907.1"/>
        </source>
    </evidence>
    <sequence length="1508" mass="164142" checksum="3FC7299DD48C145D" modified="2022-01-19" version="1">MFSALDFVTEMNVMIAAGFICLALLTQGCAGQRQTTPAPVYSRTYIVLAPNTIHPGLPLSLSVSILDAASDVVVTATILKTEELTETSVVSVSETFSPGATRVAGLVMPADEQGDSYKLRIEGSGGLEFSQTEDLKFSPKSFAILVQTDKAIYKPGQTVHFRAMAIYPDLKPYMGTFDVILKDPNGNVIQQWMNLQNTTYGVVSGETVMSETPVLGDWVITVTANNNAYDHTITIDEYVLPKFEVTVTPPPYIVSTDTQATISVEAKYTYGEPVKGTVSMDLQVLGGGKPYHVEFEIDGKGETVVTKAELADLYYGNLYRWARFTCTANVTESLTGIQQTGVGYFGYEEKPIKVAELPGNPEVFKPGLLYTAYVKVTHVDETSLTDAERRRRLVVTHSYTVSGSRESVDAIDAEVVIPEDGIIKLDFSFPTEAVSANFLVAYYYDNNERAYGYDVQKYLSPANSPSSEFLQIIAQGASLQAGTQASFEIRTTEVPPKLTYQVFSKGNIVLANSLTSVTSTNTVLTIDVTSAMAPQARLVVSYVRPDNHELVLDSININVEGAFENEVTINFNKEEVEPGEGIKLDITAERNAYVGVLAIDTSVMLLKTGNDITQSMVVDALEDFDTTSSGNDGYVYDVGFGRAVARRKRSAWCCGWWPFPIPGDTAREVLNSAGILVFTDALVYGETAPDVYFARGDVLFDAIPAAAPGAAVPESAKADSAGAPPNAAPPPPEPRVRTEFPETWLWSDYIAGDDGRVRVASTVPDTITSWVASAFSMSAQTGIGVAESTAQLRVFRPFFVSLTLPYSVIRGEKLVLQATVFNYLAFPVQATVTLSGSVEFQSLSYDENGSEKISNSDQVKSVKVPASGGATVYFPILPQKLGTVDLSVSATTEKAADAVVRQLLVEPEGIPTSFSEPVFIDFNSTQGTLSKEFTFGFPKDLLIPGSVRAQLTVTGDIMGPTMSGLDKLLQLPSGCGEQTMLSFAPDVFIYSYLESTNQDNPTVMQKAKDFMKKGYQRELNYQHTDHSFSAFGNSDPSGSTWLTAFVIKCFAQAKPFIFIDSTVVQRSVEWLIAQQTRDGVFNEPGKVIHTAMQGGVSSDVTMTAYVLIALEEVKGQRVALNLPQTFWDHVDNSISLAVGFLEEQYNRVSGDVYAVALVTYALTLADSQDTRFLDALERLAVVEDGVKHWVDPATADEQVDGWFCYYYPPPSADIEMTGYALLTYLARNEIARAAPVARWLTDQRNEYGGYGSTQDTVIGLQALSTYAGRLSMTPRNISIDVTATDSPDYSSRITVNDGNSIILQKLELPVTSGTVQTTISGTGSCLMQFTAFYNLAEVQVRPSFELTVTMLDLNKNTVNIMACGRYVGGNDVTGMSMIEIGLPSGFYADEDALKSEVKAKDNLQKYEVGRRTVYLYLNALTRNTEYCFNVVARRDKIVANLKPSNAVIYDYYKPGDQTVVSYSSKSLSESSVCQTCPTCCGLDPDSAGVRLTGQVVLVAVATLLSILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUM8</accession>
    <name>A0A8B7XUM8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Motor neuron and pancreas homeobox protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084558.1">
        <property type="nucleotide sequence ID" value="XM_022228866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUM8"/>
    <dbReference type="GeneID" id="110975976"/>
    <dbReference type="KEGG" id="aplc:110975976"/>
    <dbReference type="OMA" id="YGHRYLY"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000357">
        <property type="entry name" value="Motor neuron and pancreas homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042768">
        <property type="entry name" value="MNX1/Ceh-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335:SF4">
        <property type="entry name" value="EXTRA-EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24335">
        <property type="entry name" value="MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="198"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022084558.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="41756" checksum="7E9E186C43CDCEAD" modified="2022-01-19" version="1">MEGHKSFSIDALLSKDPPCSARAVKPRSPTAATAASTLTAVQYAGIQGQLQAALSERLAYFHAHAPSSQSANNSARMLAAAATGSIIPKPGLLNLQPPGVHGPASAVVSSKHSTAGGVAVPAIYAHPLYAGYLNGQHHGMAHLSAFHAAASEHMLMKAAAHGAGLPAGIPMDLIRGNMMMQRIGDYPGHQHPTILGKTRRPRTAFTSQQLLELEQQFKKNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRGKKVKESQIAEGEKEAAANPDEGRPEHGPAPLEKIHPEEDHVGKTEVRSDGSVEGIGIHDDDYYDDDDGEEDEDDMEDEMIAEGYLHDSSSSERANNNAGDNDNCNGGNRNRYSSATGERSLDCHPVEPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV53</accession>
    <name>A0A8B7XV53_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">E2 NEDD8-conjugating enzyme</fullName>
            <ecNumber evidence="7">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NEDD8 carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110975523</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022083766.1">
        <property type="nucleotide sequence ID" value="XM_022228074.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083767.1">
        <property type="nucleotide sequence ID" value="XM_022228075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XV53"/>
    <dbReference type="GeneID" id="110975523"/>
    <dbReference type="KEGG" id="aplc:110975523"/>
    <dbReference type="CTD" id="9040"/>
    <dbReference type="OMA" id="CQVDFPD"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000239">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="11">
        <location>
            <begin position="30"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022083766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022083767.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="21130" checksum="0EA40801C77ED8D9" modified="2022-01-19" version="1">MLKLFSLKQEKKDGEAAGKNAGVNQKRASAAQLRFTKDINDLNLPKTCRIEYPDPDDILNFKLVITPDEGFYKNGRFCFSFKIGPGYPHDAPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQFLLLEPNPDDPLNKEAADVLQNNRRLFEQNVRSSMRGGYVGSQYFERCLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVJ4</accession>
    <name>A0A8B7XVJ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein virilizer homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the vir family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083896.1">
        <property type="nucleotide sequence ID" value="XM_022228204.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975607"/>
    <dbReference type="KEGG" id="aplc:110975607"/>
    <dbReference type="CTD" id="25962"/>
    <dbReference type="OMA" id="YWLEPLP"/>
    <dbReference type="OrthoDB" id="2011702at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031801">
        <property type="entry name" value="VIR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026736">
        <property type="entry name" value="Virilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23185:SF0">
        <property type="entry name" value="PROTEIN VIRILIZER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15912">
        <property type="entry name" value="VIR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Virilizer N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="756"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1402"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1615"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1798"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1860"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1798"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1896"/>
            <end position="1915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022083896.1"/>
        </source>
    </evidence>
    <sequence length="1915" mass="209993" checksum="ACA1DC1A98C6D6C9" modified="2022-01-19" version="1">MAEENMGELLFCDTFSHENKEDLNLDLVQFPWPVCISEVRVIPRAMVAHPELQDQGRLGETSPSTFKLELFINNLNKPGSAVFEQLGVLDYVDNSKIQLIPSSTAPTDGVVLRGWYHKVTVAIYGILASHKKRAEERAVSPPPPPPPPKQSIHGSKRAADDTTEFLAHELTQKQPILPQQHHKWEWEQQEREQSAPPKRARYAEPAAETERHQPPPASHAIPSTASRRGPRTPSPPPPAQEQWEPSQPHPSEPWSSGDAAKESWKTQDTWEAGEPEEQGGQGREWETNDTWETTDTWEPGDATEWEEQTTPTEPPSQKPSYTDPWHDDHTRLPATSGGGSSGRSQKKHRKHRGPRTPPGEPQGSPSPPDYAQPGEQYQESRRHRESSRRRGGDSPRREARRDKESRREVDARRDEGRRDSEEPPVTAEPGEIVQETAEVEELFEPLTPETSPSHQFSDRETMEDDRSREPTEDTEMESIGQPYEEISDEEGMDEVGSLDGLMDTEGLEVDGLEGESWPDIVTFDPFQVELVPLTTYPAPYPVPQDQVTPAKHDASMEDSKALLDALKEHKDKEYGPRWVAALEPLPALLPQALTGLDDRSLLTLAQWSVEALSQDRARGQPIGVNMRQLKAGMRLSSALCDCGQRVAVKLLELGVLDALMSLLFGDHVASSLKLMALKALDSATNWREGIQRFLGPCPPVDGLGNAPRTYYQRLVKLLLSEQTVRVVTATTALLKKIHVYEVLTTLRDTVDSILDSDAEPSSSPAVSLKQSSKFDSGDLDTPQQHSSGPGTPLEGEVLGDCGGVSNTDIETILDCLQELCTTLRTASYSIVQPPIKAFPTTAKVTGPPSSADPYPVLYHMFQTRKLLESLLVLVSCPATSGNESIMSAAVELLTAIMKSLKGLLFFSANQAATKALCQCLTASLDEDSPQQEDGGGGGASPLQQAGLQLLHSLACLQYCDQLRQAVGRPGSDSWGQDPDPNSNDAVEVLRGLCSVSFVTAGRMALAHVFTMGDNLDCLLSFVEPKERGESPTKSRKTASHGYAMQVLSCVVQYNENIAALSTYQVQLELGCMGDAALSKWLNPIRGVKLDGDCISKMIDYINKESDELGHNLLGAGPGIVTCLRVLRHLACAPLDMQRGDCQKDLQYKLAVIQLYSSSAMNAFINIIKRLGDRLLRPWQQGYSLSTTQVHLVEALVSPALQLVKVMLSELLTTGSVQFKDERLVTCLLPLHTVLCSVPSSIMLPSDAQRIQSDIIDILLSYTMMPSTQPDTEEGIASSSWTVMLKEVLQYIQSAACAYIGGLTVLSELLPLPLPMQAQEPLSATEVQQALNLRRLWSLHLHSESVHIQQIIKDLGGSSCPPLQQILRRVCWQLADLAAPTALTVVRSLLDVLIESLAQGEEGGKKAQPAGETTGEGEEANKKTQPCNSDAARILTLVVYLVSQPAIKAPLLHLFRSSLKSDEKYSELLPWLLSLLNVVSDSSFHLQAQECIVALLQSICGPEITLLSTDTLSVNEQLANSLPGKEHMEMICSALLDHVTSPDQSYASILPSLRTLSMLLDHDYGFLFVKCALDKTPGAFHSLFTRLQTSFHKDSSDYLSTLSTALDLLQMLLTVEGGGPSSEGEQEPCPEEGGAGGSSAGLYRTKALSAAQLKEYLVWGGKTHPVSQLEKTLIECCKEDEILESLLDSISGLIQTLDSPEEPDPAKTGPGQSHRSLLLQEVTLPAPLSFSEQFSARMVFFIGDGEDDRLNAGFWLGPPGLDDGDIEPDMVPCDLEELRLTYLPDLDLRAELEKDLSAENLPREKDQKKRSGRRRYESLTSRSQYRFNYGIKRAHNQSSNYGRQMPGRSGRGYDLFRQRAQNTSRPPSMHVDDFLAAQAIETTDTKKPQRGPPQGRSGRGGNFMGGGGGGGGGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XX62</accession>
    <name>A0A8B7XX62_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial</fullName>
            <ecNumber evidence="28">2.6.1.39</ecNumber>
            <ecNumber evidence="27">2.6.1.4</ecNumber>
            <ecNumber evidence="3">2.6.1.7</ecNumber>
            <ecNumber evidence="29">2.6.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="40">2-aminoadipate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="33">2-aminoadipate transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="36">Alpha-aminoadipate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="35">Glycine transaminase AADAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="39">Kynurenine aminotransferase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="34">Kynurenine--glyoxylate transaminase AADAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="37">Kynurenine--oxoglutarate aminotransferase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="38">Kynurenine--oxoglutarate transaminase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="32">Kynurenine--oxoglutarate transaminase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="31">Methionine--glyoxylate transaminase AADAT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="43" type="primary">LOC110975863</name>
    </gene>
    <organism evidence="42 43">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="43" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="25">Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O</text>
            <dbReference type="Rhea" id="RHEA:69104"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57678"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:69105"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-oxoadipate + L-kynurenine = L-2-aminoadipate + kynurenate + H2O</text>
            <dbReference type="Rhea" id="RHEA:70047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:70048"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O</text>
            <dbReference type="Rhea" id="RHEA:66044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
            <dbReference type="ChEBI" id="CHEBI:74359"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66045"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O</text>
            <dbReference type="Rhea" id="RHEA:66060"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35177"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
            <dbReference type="ChEBI" id="CHEBI:58455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2O</text>
            <dbReference type="Rhea" id="RHEA:66076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28644"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58441"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:66077"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O</text>
            <dbReference type="Rhea" id="RHEA:66092"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:66093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>4-methyl-2-oxopentanoate + L-kynurenine = kynurenate + L-leucine + H2O</text>
            <dbReference type="Rhea" id="RHEA:66068"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:66069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4-methylsulfanyl-2-oxobutanoate + L-kynurenine = kynurenate + L-methionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:69096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:69097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine</text>
            <dbReference type="Rhea" id="RHEA:69112"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57499"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:69113"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-kynurenine + 2-oxoglutarate = kynurenate + L-glutamate + H2O</text>
            <dbReference type="Rhea" id="RHEA:65560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
            <dbReference type="EC" id="2.6.1.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:65561"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-kynurenine + glyoxylate = kynurenate + glycine + H2O</text>
            <dbReference type="Rhea" id="RHEA:65896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
            <dbReference type="EC" id="2.6.1.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:65897"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-leucine + glyoxylate = 4-methyl-2-oxopentanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:69128"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tryptophan + glyoxylate = indole-3-pyruvate + glycine</text>
            <dbReference type="Rhea" id="RHEA:69124"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine</text>
            <dbReference type="Rhea" id="RHEA:69116"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>glycine + 2-oxoglutarate = glyoxylate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14089"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="EC" id="2.6.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:22884"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="2.6.1.73"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine</text>
            <dbReference type="Rhea" id="RHEA:69120"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:66052"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58454"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66053"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="26">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.39" evidence="28"/>
    <dbReference type="EC" id="2.6.1.4" evidence="27"/>
    <dbReference type="EC" id="2.6.1.7" evidence="3"/>
    <dbReference type="EC" id="2.6.1.73" evidence="29"/>
    <dbReference type="RefSeq" id="XP_022084401.1">
        <property type="nucleotide sequence ID" value="XM_022228709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XX62"/>
    <dbReference type="SMR" id="A0A8B7XX62"/>
    <dbReference type="GeneID" id="110975863"/>
    <dbReference type="KEGG" id="aplc:110975863"/>
    <dbReference type="OMA" id="FMPGEPF"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047958">
        <property type="term" value="F:glycine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047315">
        <property type="term" value="F:kynurenine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050094">
        <property type="term" value="F:methionine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000071">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000166">
        <property type="entry name" value="Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF19">
        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="41">
        <location>
            <begin position="57"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00056991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00060610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00066546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00067027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00067059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00074091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00075068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00080697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00080916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00081438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00082040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00082705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00082796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00083236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00083286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00083735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="41">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="RefSeq" id="XP_022084401.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48248" checksum="1A7FBA1B95D993CC" modified="2022-01-19" version="1">MNYARFLNAVSRARRPSPLRGLTEILQQSPPGTISMATGLPNVEQFPFREATFQLMDRTNMHLNASEMKKALQYTATPGLPELRDWLIDMQMKIHNPPTLDSSNEDSQMDLIVSTGSQHALSTSCEMLLAKGDNVLTSSPLYPGTVAILRPLGVEFLTIKVDGDGMVPDRIREVMSQWDPEEGQSESSDIPRVLCVVPNGDNPSGAGLTLERKKDIYSIAQKYNMIIMEDDPYYFIQFNKPKVPSFLSMDVDGRVLRFDSFSKILSAGMRVGFLTGPKYLLQRVNMHMQASVLHTGGMAQMLIFKLLEQWGMEGFLNHTDKVAAFYEERRDMIMESADRWLRGLAQWHKPRGGMFLWLKLLGIRDTTDLIMKKARHKGVLFVPGSVFYPESDRISSHLRAAYSLCTPEQMDQGMQRLAALVKEEMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXH2</accession>
    <name>A0A8B7XXH2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histone PARylation factor 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HPF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084496.1">
        <property type="nucleotide sequence ID" value="XM_022228804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXH2"/>
    <dbReference type="GeneID" id="110975925"/>
    <dbReference type="KEGG" id="aplc:110975925"/>
    <dbReference type="CTD" id="54969"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019361">
        <property type="entry name" value="HPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13386:SF1">
        <property type="entry name" value="HISTONE PARYLATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10228">
        <property type="entry name" value="HPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBZ-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022084496.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47801" checksum="EB329219A3D6EFE5" modified="2022-01-19" version="1">MGKNDSGKPACKYGADCYRTNPQHLAGFWHPKKGKRKGENQDADDGNIGVAKKRKADGADEPQLPGMSGDSDTKTSVEEKVEEKTECNEEDIEKESSQECTDYAQPATPSDLDPREEIKWKFKMEMPEDFYDFWEFCQSLNKKNPKDALKDTLGLQLVGPYDVLAGNLKKTPQSKRSSYCLHWRYYYDPPEFQTIVRGDDETQHHLGYFRDEPKELPVFVAANSAKKSCSISAQGGNIFAAVKLHMDKLCKATKDKAEQSKIQSLQKPLTDWAKKCGHSLDSKSQAMKDREKKVVAKTFHGTGIVVPIDANEVGYRELPETDANLKRIFKKIADSKNEDERNKNFEPLDEIINFVQFANDECDYGEGYELGIDLFMYGSPVLHGTIRNVLPLAYTLLRREEFGKILESHLEDRRKDDLSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXR7</accession>
    <name>A0A8B7XXR7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 14">Guanylate cyclase</fullName>
            <ecNumber evidence="2 14">4.6.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110975995</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="2 14"/>
    <dbReference type="RefSeq" id="XP_022084586.1">
        <property type="nucleotide sequence ID" value="XM_022228894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXR7"/>
    <dbReference type="GeneID" id="110975995"/>
    <dbReference type="KEGG" id="aplc:110975995"/>
    <dbReference type="OMA" id="RKRDFNW"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016941">
        <property type="term" value="F:natriuretic peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007168">
        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000004">
        <property type="entry name" value="Guanylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050401">
        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920:SF494">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11920">
        <property type="entry name" value="GUANYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034933896" description="Guanylate cyclase" evidence="16">
        <location>
            <begin position="24"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="432"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="838"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="775"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022084586.1"/>
        </source>
    </evidence>
    <sequence length="1031" mass="115520" checksum="7AFBC9875FA10EBB" modified="2022-01-19" version="1">MPPPSSLVLLIVFEVINLQISEAGTFDESPTIHAGLLLETGGAESFDRVRIQPAVDIALETVRRRVDTGVYLNFSLTYEYQSTGTRCIPSPMIAPGIASDMFHRQGVRVFLGPGCSFQCKTVADLAAYWNVPVLTGAATSGDLGNKDAYRTLTRSGFHLGPLGQFAVALFNRWSWTRCVVIWDDVGLWRIISFTIRSRLQQAVIFVIAPVDVVRDIMIKAYQAGYTSGEYVFFSVHLINNRWRFGDSSWQQGDAFDAETKLAFEALMTFRLFEPSNDDLRDFQEELELRRKRDFNWTSPAGDDYNFFTSAFHDIIILFSLALNETLSENGSLLDGYTFSRKMWNRTFQGVFGNVSINANGDRDTDYSLWDMTDAVKGDFMVVANFYGATGELKFVGDIAWPGEVTGPPPDTPLCGKVKRDADILSRAWQIKWEELQMQNDNARGPRRSSLSLGSAAIDTDEVKQVFTKTAFYQGRTVAVKKLFRNEVDLCRNTMIELKNMRDLEHPNLARFIGLCIDVPNVAIVNEYCPKGSLMDILQNDSIKLDWLFKHSLICDVINGIQYLHRSPLSVHGRLNSSNCVVDSRFVLKLVDFGLQSFRVGDAQDRGSHAQQTSTIGSLFQVSLFVRFLYTVLLYMISPGALSAPAKERQVVTNYRYAELLWVAPELLRDPRRGPTKEGDIYSVGVIMREVATREGPFEAELKNMEVSEIVQKIKSPPNGMQCFRQRTSTENMDANVSELIKKCWAEDPKERPTANSLNASMDKISRQKNIGMGILDNLLNRMEQYANNLEELVEERTAAFLEEKKRAETLLYELLPRTVADRLKQGEAVDPESYASVTIFFSDIKGFTELSAHSTPMQVVILLNDLYTCFDGIIGHYDVYKVETIGDAYMVVSGVPVRNGIAHAREISNMALALLGAVGSFKIRHKPDTKLKLRVGIHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGEAMKIHVSADTKSLLEDFGCFQLELRGAVEMKGKGTQTTFWLLGSNDITLQGDEDLPFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXS4</accession>
    <name>A0A8B7XXS4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear cap-binding protein subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110976594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NCBP3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085689.1">
        <property type="nucleotide sequence ID" value="XM_022229997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXS4"/>
    <dbReference type="GeneID" id="110976594"/>
    <dbReference type="KEGG" id="aplc:110976594"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085689.1"/>
        </source>
    </evidence>
    <sequence length="659" mass="73812" checksum="9392E3526CF29912" modified="2022-01-19" version="1">MSRGETGLRKWRPPVSKLALISDINKMAEKGDGRSQPVLPRNSDEKDDPLDLLQSESSESESESRKKQSDEKITNKREFKGDGIDKSLSELATNSEGCWGPRTRPRKLGLSQRGSVACVPTSWRDVCVLPSGPWHSLGLTELKKENVKRYPNKNSGNFVTGFDVHSKEAKIKRRERARRFGIKSPDKTSKTEKLSSVILPPGSTIGGHRVRAEAIFILGVDEMSTQDVFNYFKDYDPSSIEWINDTSCNVVWLDPHSAARALFNMSQPQHILPQQVHVLPPQPSPPPVREEQEPEPMEQEEEDDDDDFLDLVSDRETGEQERHRRSTSRSPNPTPSAAPSAHSPPTSSTLGRSMDDNSTMEDDMDMGPVHLSHEEATRTGLPCPEAEKELVMRYATTADKKVFDPSHRSQYYIKYGNPNFGGMKGLISGSLKKKIREGKFVPGQRKRRYGDDDASDDEDRQEYARKRRNHGNGDDSQSHRRMEERDSDDGDSVEMDLRLLTKPVQPRRPMRMYADDLEDQIKAVSRNKPAVATPQMTDARERLRMNHPVATSRQGLLAYQASDDNSGNSGNESDTGGGFLTGSIPNLKIMLSNDGNAWDDDDDDEEDDDDEGDDAGAGNEVAPPRGLPDLRSRLKNRHSHPHILDTLPSLSVQVDRDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZ21</accession>
    <name>A0A8B7XZ21_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Crystallin J1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085280.1">
        <property type="nucleotide sequence ID" value="XM_022229588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZ21"/>
    <dbReference type="GeneID" id="110976380"/>
    <dbReference type="KEGG" id="aplc:110976380"/>
    <dbReference type="OMA" id="LHWIYND"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF17">
        <property type="entry name" value="SELENOPROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022085280.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="37459" checksum="ADB7B296AC37DDAD" modified="2022-01-19" version="1">MSSAADRSSRGLAAIVGCLVSDAAAQPLHWIYNLDKLDSIVGSNTDSLEFWEPSQNPYYRIETGRGTAYADHTIALMESLVACEGYDKADFGDHLQAMFGPGTDYDNDLNKTFVLKSGVQSGYPINGPWRPKAIKDFLANRAEGKERTGSDHMHDMHAVVGVVPMVALYAGRSDMLEKVEESIAVVTEVEEAIVVGLAAARVLEQFILNPDMDGDAALTAVMTDLASPSRNNPTDLDRAVIGQLKKVMDKKACEHREAAQKYFLNNLPGAFQSALHCLVNHSELAPAVRTTMMAGGCNASRSGFIGACLGARNGLQGIPETWKSKTLAYPRILELSRKLVAIQPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZW4</accession>
    <name>A0A8B7XZW4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110976648</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022085802.1">
        <property type="nucleotide sequence ID" value="XM_022230110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZW4"/>
    <dbReference type="GeneID" id="110976648"/>
    <dbReference type="KEGG" id="aplc:110976648"/>
    <dbReference type="CTD" id="1801"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022085802.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51102" checksum="2EF68C5A959D4C01" modified="2022-01-19" version="1">MAEKTVVISAKSSQPKRIVGRKGLRVAHQIPDEILNNQDLKNAIEQLPSNYNFEIPKTVWRIRSTGAKRVALQFPEGLLMFACTLADIVERFTDADTLIMGDVTYGACCVDDYTAKALGADLMVHYGHSCLVPISMTEGINMLYVFVDIRIDTAHFVDTVRHNFNPGTSIALVSTIQFVAALQSAYEQLSEDYRLQIPQCKPLSPGEILGCTAPRLGNVDNIIYLGDGRFHLEAVMIANPGIQAYRYDPYSKLFSKEYYEVKRMHELRQEAIRQACMAERFGLILGTLGRQGSPKVLEQLQARLKAVGKDYVLVLLSEIFPDKLKLLPDVDAWIQVACPRLSIDWGYAFEKPLLSPYEASVVLQSIEWQSTYPMDFYSNTSLGPWTVNNEANLPPRPTRKSGPRKAGRHIQVTLDVERLGEMKLAQEGKDEKASGSSDASNKACDACEHCSCQDGSPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZZ8</accession>
    <name>A0A8B7XZZ8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022085615.1">
        <property type="nucleotide sequence ID" value="XM_022229923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZZ8"/>
    <dbReference type="GeneID" id="110976554"/>
    <dbReference type="KEGG" id="aplc:110976554"/>
    <dbReference type="CTD" id="51651"/>
    <dbReference type="OMA" id="GHAAVEC"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000811">
        <property type="term" value="P:negative regulation of anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000210">
        <property type="term" value="P:positive regulation of anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085615.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19028" checksum="1AA467FFC3B66DC3" modified="2022-01-19" version="1">MVKFEDLMSPMTFNLIMSMGAGVLLGWLLKGKYGRQVMLQDQQAAETAASGDNVSVMGETGEYKLVLVVRTDLKMGKGKVAAQCSHAAVSCYKQAARRQPDMLKEWENYGQPKVVVKAPDEEVLIELALKARSLGLTTAVIQDAGRTQIAPGSRTVLGVGPGPASLVDEVTGELKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0W9</accession>
    <name>A0A8B7Y0W9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Neurotrypsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110977207</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086813.1">
        <property type="nucleotide sequence ID" value="XM_022231121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0W9"/>
    <dbReference type="GeneID" id="110977207"/>
    <dbReference type="KEGG" id="aplc:110977207"/>
    <dbReference type="OMA" id="ANYQQCE"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034587909" evidence="10">
        <location>
            <begin position="23"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="11">
        <location>
            <begin position="39"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="193"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="300"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="325"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="338"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022086813.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="43169" checksum="C7104FCC7818F3D4" modified="2022-01-19" version="1">MMAFYSILTALVVIELNGLCFAHPINNAPAPPRRTSAPCTSGPLGMESGAIEDSRITASSFINSGFEPHTARLNVGIQGWIPSLPANQWIQVDLGGRTAITGVVIQGYSTGSSNYITAFTVQYSVSGGSDWQDMLDADGDIIRFSVSSGRPTNVTFPVVPMARYLRILPQTWDHKEYRLRFEVLGCRVSDGMLWLVAGDDALSGRVEIYHEATLSWGAVCSNGWDLSDAHIACRQHHRFLEAVQAGASSAGTDLPIVMNRVACKGTENRLVDCPFICTEYQQCNSSRVATVVCRPQMNTVRLVGGSNNSSGRVEVYRSNTWGSICDNDWDINDAAVVCRVLGFSGAQAAKSGAYFGQGSGPVHMDGVACTGSEGNFGDCPSSCWEEPQCSHNQDAGVICQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y171</accession>
    <name>A0A8B7Y171_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Lysocardiolipin acyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110976777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086040.1">
        <property type="nucleotide sequence ID" value="XM_022230348.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086041.1">
        <property type="nucleotide sequence ID" value="XM_022230349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y171"/>
    <dbReference type="GeneID" id="110976777"/>
    <dbReference type="KEGG" id="aplc:110976777"/>
    <dbReference type="OMA" id="VANHVAW"/>
    <dbReference type="OrthoDB" id="186786at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="94"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022086040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086041.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="45113" checksum="6CB61B97C9F819E2" modified="2022-01-19" version="1">MTAPSHLPLFPPLSLLGVFKGTVCTLAMGLTATLGSVFMLGPIMPLMVIQPRLFRWINDWMMNLWLLLPVALMEIVMGVTIMTSGDTLQSDEGSIILMNHRTRLDWMFFWVVLHRQSTLRTEKIILKNDPKMAPGFGWAMQVACYIFLRRQWEVDKPWLLSMLEYFGLLQYKGQFLIFPEGTNLDAKTKLRSDRFAQKNNLPLYQYCLHPRTTGLIFLTQELRQKNLLDTMYDVTVTYPDLIPEHGELNMVVGNLPTRVNFHIRRHPQSSLPASKEGLESWCLERWRAKEAALGAFYSGGKDCLVFPGGEGDGGETHTLESDRRTLYLAVLYWLVFLLAVFILLWYSVLARWYLLVGTIYFIYQLVVRGGVETSIMESCRWFYKQKERRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1G3</accession>
    <name>A0A8B7Y1G3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110976647</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110976647</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085801.1">
        <property type="nucleotide sequence ID" value="XM_022230109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1G3"/>
    <dbReference type="GeneID" id="110976647"/>
    <dbReference type="KEGG" id="aplc:110976647"/>
    <dbReference type="OMA" id="PESMANT"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085801.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27519" checksum="1C04FC074EA11E78" modified="2022-01-19" version="1">MHSVLVTGANRGVGLEFVRQFLQLEESPKHVFACCRNPEDAKELQNLSKDKHQLKIVKLDVTDKATFPDAVETVNQNVGEEGLGVLINNAGVLQRGSTETTSMADMEESYRVNVMGPFAVSQAFLPALKRAAETNRLTDNPKHLSTGRAAIVNITSALGSFQLCTSSRYIPYRTTKAALHMLTKCMTFDLTPQGILVVAMHTGWVQTDMGGKNATLTPRRSIQGMLRVLTRLSEKDAGKAFTWEGKLLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y382</accession>
    <name>A0A8B7Y382_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Meckel syndrome type 1 protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110976943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022086366.1">
        <property type="nucleotide sequence ID" value="XM_022230674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y382"/>
    <dbReference type="GeneID" id="110976943"/>
    <dbReference type="KEGG" id="aplc:110976943"/>
    <dbReference type="CTD" id="54903"/>
    <dbReference type="OrthoDB" id="10263520at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF4">
        <property type="entry name" value="TECTONIC-LIKE COMPLEX MEMBER MKS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086366.1"/>
        </source>
    </evidence>
    <sequence length="564" mass="65124" checksum="507C815597D1A8FD" modified="2022-01-19" version="1">MAEDSGGGGGSDLGTAYYRSRDPIKNFKIKVHLKRVTGTSLVPTAYSNEEAGPSHEGMEMRPLGSRRSMKSQVRPEDDETYTLKWQEKLFSQLEVELYRDRDNCKRPIEERYHREITAMYNDGDGRPTTRIFSYVDHDTFASLEEQNAVTTSSKETPSFLTQKMQNVRRRKQTERRNGYGDGSSFQPKINPVMEAPSEEHKRSAHVIDTPVQTMYIMADLSAVEDEPTILDEYILCTIKYDTHGVLSVTPDFNRYRPPYTIVTESTQRDTFEYTLELASLPMARRDQDRETKMFRELYQRHMDYVGAMVGHDFEQVASGILRLLVYGEIVSAKNYEYDNLYVHFFVELPKHWSTDTAQQLSGVTQTCSTKEIDRENVAYFCYPFDLELFYKQEELGEEEHREPLLPQWPQIFLEVLSIDSWQRYRTEGYGYLTIPSTPGIHTVEVQTWRPSGQHYFNNLRRFFIGGSPELEDPTYVAVPPTHEGSVISRFGFRTEATGSVTLKLNLLQQSQIFMDKVDSKRKVGTLLDRLGGLTMQASVQNVLELFQRARKRMQAAKETLSTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4Z0</accession>
    <name>A0A8B7Y4Z0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tripartite motif-containing protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110977261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086916.1">
        <property type="nucleotide sequence ID" value="XM_022231224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4Z0"/>
    <dbReference type="GeneID" id="110977261"/>
    <dbReference type="KEGG" id="aplc:110977261"/>
    <dbReference type="OMA" id="KCITEWV"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042755">
        <property type="entry name" value="COP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44080:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022086916.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="46052" checksum="BD090CA4E9FC9578" modified="2022-01-19" version="1">MADMADMAEGEELPLSIPVKAVSEHFTCPICMERLSQTYITPCGHRYCGICIKECVNRRSKCPCCNTKVTADKLYPDWAFDNLISMVSTEKSKAEDQYFVKLIQEAGHHEHEGANHREESPIVGTLQKHLKTGLATHEQYYQDFKREFTQRIQEVNLQMEALQGGGDDVLLAQQLQELEVKKQTLHTELRTCTQLLVDAYDKYLADHLPTPSLLPVTVSVRLQGKNVSLPDIKIKPHSSISEIKDVIAMAMEARGDPIASFPDDQVQFVLLGPVEKGREISAELLEELLQSPDSMERSEVIRLLPRGCHPLLEFGVKPGSEVVVAGPLKLESEMPKQCFAQTFVKDKGQSMDYFTCKDCAFKWVCRSCKDFCHKDHQTVPYIMGHQPTWACCYCPRKKKCQLGELRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5D8</accession>
    <name>A0A8B7Y5D8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHD finger protein 24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110977719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087757.1">
        <property type="nucleotide sequence ID" value="XM_022232065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5D8"/>
    <dbReference type="GeneID" id="110977719"/>
    <dbReference type="KEGG" id="aplc:110977719"/>
    <dbReference type="OMA" id="MEHETIN"/>
    <dbReference type="OrthoDB" id="9978298at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031946">
        <property type="entry name" value="KIAA1045_Zf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16744">
        <property type="entry name" value="zf-RING_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KIAA1045 RING finger" evidence="5">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022087757.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43304" checksum="28221B3846F6C818" modified="2022-01-19" version="1">MGTVVTKKKRFEVEEDLEVDVGEATKQAKRVGRLSMIISAMRPSARTDGAVQGHHASSAWSKAFSKRSRLGLLPPPTETLSEPPEEYNARLTREEELRALDFHDPEGKLKYDAELPQSETEDQCAICTMYKRDTTLLCRVCGQPYHHGCLIGRGLGLDTNSSRAMENAESDIGWSCPDCETLSELLPMDNMSELMIQFDSYDADGDSVINITDYMEHETINYQQKNNESLPSSKARECEEMFRTYDRDNDGSVSWWDYSMVETIKWLQRQPQNKLLEYLKPKEIAKLRSFFRMSDKRNVGLVTVGESEQAYRGWLRALGLHETEEMMHSFEKSSWSDECNKMITWERFISSKALALITSRPNTITIKPFVTTREETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5I6</accession>
    <name>A0A8B7Y5I6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977364</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087101.1">
        <property type="nucleotide sequence ID" value="XM_022231409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5I6"/>
    <dbReference type="GeneID" id="110977364"/>
    <dbReference type="KEGG" id="aplc:110977364"/>
    <dbReference type="OMA" id="HRIRRYH"/>
    <dbReference type="OrthoDB" id="7701031at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34718">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34718:SF2">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087101.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37654" checksum="953CB868FD0B3197" modified="2022-01-19" version="1">MANKMILKKTSNFQNDDAELIHRQSLTRDYQVIQIKDENRRIKMILRATDNSFTTLGSLETALARPVTAFGRSSFPRKSKSTSQHACYRHSVAKAVAKSVLQPAVRKRLLSQDEGHCKPKRPCVAESRDCDNDKKSPSIDGDEFVRVGLTAKDIEILDDGEWLTDEHISAAQRLLRRQFPAFGGLQEPVLGEILQFEPMTTDGAQIMLNGGGHWVTICRRNNEVKLLDSKNEGLNSRLSSQILNLCGDKAGRSSGLQVQLPVMHPQRGSSDCGLFAVAYATEVAFGGRPELTVFDQKAMRKHLKYCLESQKMKPFPRKNCAQRTSRNVGSKAQALRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6L2</accession>
    <name>A0A8B7Y6L2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110978280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022088848.1">
        <property type="nucleotide sequence ID" value="XM_022233156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6L2"/>
    <dbReference type="GeneID" id="110978280"/>
    <dbReference type="KEGG" id="aplc:110978280"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="8">
        <location>
            <begin position="17"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="429"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022088848.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="51306" checksum="8C03FFEC88D71F4A" modified="2022-01-19" version="1">MEDDVQSLDEIRAEKQIELHLCKGKILVWDADDVKLLRQTHHIVGSLVGSLPRSPRQNAQLGLPLQLMPEEAAVLIEYADVAKMVNVKIKDPSADNVTSFEEARQKSFCEQQTMWDTVNAKKKQDFANIIALGRTTKKHRRAERAKKQKRGKASSSVESRGDSTVRCASDSYKLLEEDGATRKRRKIQDDFSVVAEVENQEGSSAPSLATCYAEQAEDVTSENAESTRSRLESFLSNMESSQLSPADCARTNDSDADKNIRRDVETVKLDAVKGGLREIKPFLEVDSNVADNSTVGHIQKDVHIDEVKEEEKPSTVTDGSPKARLTISQQSMEDDFCSDLLPSEQQCGTSGPPGVVSDPGPNTATDTSGPAPAPLSSPEHRPDDGDVFKKPPDPRPCSGYLVHIVTASPSTPREEVTEWMYPTSQQELLKYRVFRDLWEMGYYLTSGCKFGGDFLVYPGKHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y726</accession>
    <name>A0A8B7Y726_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-4C adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110978033</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088362.1">
        <property type="nucleotide sequence ID" value="XM_022232670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y726"/>
    <dbReference type="GeneID" id="110978033"/>
    <dbReference type="KEGG" id="aplc:110978033"/>
    <dbReference type="OMA" id="INQQENG"/>
    <dbReference type="OrthoDB" id="5955379at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <sequence length="2121" mass="223732" checksum="651F140E0964A5DA" modified="2022-01-19" version="1">MMTVCGAYSTGNMALFGGLVVGLFFCFPLTPCRGLTLSDNNACLRLEISAVTYNETFAVRERQPYQRCNRKGRRCRTKYRTIYTTGYRLQSKLVNGTVVECCEGWEYQTTTDDCLLPICDPTCISGQGVCTAPNTCTCSPGYEGSRCEHTCQAGHYGQNCASTCSCQNGAACDPASGACSCLPGWQGSTCSQPCAEGFYGDHCSSSCQCRRNSSQCDHQTGLCSCHSGWTGALCDATCPAGTYGEGCNGVCGCQNGASCHHVNGSCSCQPGWEGTMCENACQEGFYGNGCSNTCQCQNGAHCDKETGHCWCTAGWQGDTCGEPCQGSYGLDCRHLCQCQNNATCDPVNGECRCTPGWIGEVCNQPCDQGSYGTNCSATCLCLNGAVCNHVTGACYCTEGFIGEHCGEVCPEGHYGLGCAYSCSCLNGASCNPATGQCQCTAGYTGYQCGQHCPHGYFGLECQSSCECENGICDHISGYCACHPGWQGDACMVTCDTGHYGAQCQDQCECHNGATCDHVTGACTCSAGWQSERCDLECDVGFYGTNCALACQCQNGGICHHVTGACNCTAGYAGDLCQEHCSAGTFGEGCTLTCACLNGATCHHVTGLCTCADGWIGSTCNQSCPVGYYGNGCTAECRCQNGATCDHVTGDCYCTSGWQGVHCDSPCDEGWFGQDCSLECFCYNGASCHHISGDCLCADGYIGNLCEQPCSQGEYGPDCSLDCACENGASCDHRNGSCTCGPGWLGSTCNTTCPSGMFGMSCLSQCTCQNGALCDPVSGYCLCQPGWVGDSCEDECMQGHYGQDCGFLCLCQNGAHCDPVSGLCTCAAGYRGTICEALCQQGRYGQDCQEVCACQNGAPCDHVNGICTCLSGYIGETCNATCPEGQYGHRCLQQCLCQNEAGCHHVDGTCNCTAGWTGLLCSEACDDGYYGYQCREQCMCQNQGLCNPVNGECTCQAGWQGDHCERPCDPGYYGDGCASLSGCQNGAITHHVTGVCHCSAGWTGTLCDEQCPSGLYGNHCNQTCLCENGATCDHVNGTCYCSDGYVGVFCDQACEQGFHGQDCEAACLCQNNATCDHETGNCACTDGWIGPVCNTTCEEGFYGHQCGQECLCENRGLCDHVTGGCSCAPGYIGEYCQETCPRPGDGYGSGCLSQCDCLNNAFCHPINGNCSCTPGWLGDRCGDACPEGFYGNGCQHTCVCQNGADCDHESGNCLCQPGWRGAVCSEPCSLGTFGPHCEHACTCQNGAACHHISGYCNCTDGWQGTSCNTTCDSGAYGWRCGQECQCQNGAACDHVTGACSCLPGWQGEYCDELCDSGFYGESCSLTCSCMNGAECNPFNGSCSCTAGWTGAWCQTRCSGGHFGVDCRYLCTCQNDGTCHPETGYCTCAPGWQGDSCQYRCPQGFYGENCHSVCPCQNEGVCHHITGACTCPAGWISATCNTSCPEGTYGIGCASQCICHNNASCDPQSGHCFCKAGFYGTLCESNCSAGYYGSYCLQKCTCKNGAICDKVDGHCTCSEGWQGSNCSAPCDEGSYGTDCQNVCDCQNNATCHHITGACLCQPGWEGDKCQLSCPEGMYGQSCGLSCACVNHVKCNPVDGSCTCLPGYQGGMCQYLCEEGSYGQDCLATCQCVHASHCIPQTGACQCSDGWVGELCDTACEGGTYGPQCSLSCTCQNNATCDHVTGECDCTPGWMGTTCNETCWEGMYGQKCLESCPCMNGAQCNHITGACTCQAGWIGANCEQSCPKGRYGDGCQLDCACLNGAGCNPATGACHCAPGWEGDICSSPCIQGSYGDQCSLTCLCENNSTCDHVTGHCTCTDGWTGWHCNQPCPPGFYGLECQYTCGCFHGSCDHVTGLCSCSAGWQGDTCVVPCNGSYYGNNCQQECPCQNGATCHPVNGTCWCPAGWTGVFCQSTCEWGFYGLDCTLQCPCPSGTCDPRNGTCLEPPECAENRWGPDCEHTCVCYNGAVCNQTNGKCLCKEGYSGDKCQFQLPTQKPVITFDGNRTAADSGENTKPYNKRDVAIFASSLGLGLIGLIIIIACLVRRRQRQKQLNIPKLSEADLMASRGRILSVSSETTNENRNLLKAREKKSKKTFEPKPSHTNGNQAWMFENPLFGDGEALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9E2</accession>
    <name>A0A8B7Y9E2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110978461 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110978461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089172.1">
        <property type="nucleotide sequence ID" value="XM_022233480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9E2"/>
    <dbReference type="GeneID" id="110978461"/>
    <dbReference type="KEGG" id="aplc:110978461"/>
    <dbReference type="OMA" id="GESWRIF"/>
    <dbReference type="OrthoDB" id="10042983at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNT" evidence="2">
        <location>
            <begin position="101"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022089172.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="28422" checksum="3074C7E15E4B2191" modified="2022-01-19" version="1">MKALVVQPMVSELHHFTLSDIKRQCLPSENWKKLHPSILVERRDGKTVTKSPENSRKLCKRQLVNQWLTLKRKASTLPVVSSHTCSSGGSSRDVNGSHDVQLSKHQDHAVDAGELPSDPRLWSPYDVTAWLSRMEESHGLDVDHSFFQMNGRGLCLMPLKGFLFRVPDHGGLLYEDFRGRLRKCLLMPGDETSGPTANKRTESTAHRGGATSQSGYETAQWPLPPVAKCGEVVVAEETSVPDFKGRVSPLTYHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAF4</accession>
    <name>A0A8B7YAF4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U3 small nucleolar RNA-associated protein 6 homolog isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">U3 small nucleolar RNA-associated protein 6 homolog isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110978563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089355.1">
        <property type="nucleotide sequence ID" value="XM_022233663.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089356.1">
        <property type="nucleotide sequence ID" value="XM_022233664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAF4"/>
    <dbReference type="GeneID" id="110978563"/>
    <dbReference type="KEGG" id="aplc:110978563"/>
    <dbReference type="CTD" id="55813"/>
    <dbReference type="OMA" id="CKQWNAK"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056907">
        <property type="entry name" value="UTP6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24892">
        <property type="entry name" value="UTP6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 homolog C-terminal" evidence="7">
        <location>
            <begin position="300"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022089355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022089356.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="68958" checksum="7BF9E1ED7F94B216" modified="2022-01-19" version="1">MAEFVHQNLEETLLELEQLERVGLFTKVEIKTIVKKRTGFEYRLVRLRKDKQDFLRYIQYEVNFLALIKKRRERIGYFFKKDEIEYAIIRRIQKLFRRACTMFCDDQKLWFSHMQFCKKWNMNNELSRLFTRLLKVHSSNPALWIIAAKFQMEEIKSAENARSLLLRAIRHHPKNHKLRVEYFRMELMHADKQRKRWALLQQGNMEAREEGMEDPILKGKVAMVVYKMAIQDIPGDIDLHLAFLSVCKKFDFTQDLEEEIYQDLLEAHPENELMWDAVAKRHLTADSNGSESIHLAEETQCHEVYEKAVKRLPTAKMWSMYINCCIDRLQLRGMEDISDKRAEKTVQVFASASKQSSLPDDLYVKWMHLLQNLGKIDEAKDVAASAIVTHRHSAAVWEACLRLSIQDSGMGKEHQQAEVSQLFDSAISFVKAKHALPLWRLGLEWCLIMNPDNVQEIFKAAIKEPPAVSTPMKIVYLEWVAIKKGISKARKIYKRLSRERPLSVDFFKQYITIEQAQPEPNMARIRRGYEDALAEFGSSRPDLWLDFIRLEKDSMQAAQLHWRAMKALSGPGLEDFTNGYTLLQTGHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAN4</accession>
    <name>A0A8B7YAN4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Trypsin alpha-3-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979093</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090309.1">
        <property type="nucleotide sequence ID" value="XM_022234617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAN4"/>
    <dbReference type="GeneID" id="110979093"/>
    <dbReference type="OMA" id="WECGDAN"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000166">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034916959" evidence="7">
        <location>
            <begin position="20"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090309.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28097" checksum="8E00CEE408AB1618" modified="2022-01-19" version="1">MKFFIPLACLLAVLTPALGRRIVGGSESVPHSRPYQVALYTDPSGSYQYCGGTLVHQRWVVSAGHCRMRPHTYVGLGYHDKYNHSVAGQQLLKGRWFRHPNFHSGTFDNDIALIKLGKNADLSSSKIATIAIANKQPAAQTKLLVSGWGTISLGGSSSDALREVVVKVQTLTHCRKAHDPVIVTDNMFCAAAKGKDSCQGDDGGPIVSGYGDGTHDPGTTLEGITSWGNGCAISRYPSVYIAVGNYCDWIKTVTNNAVQCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAU3</accession>
    <name>A0A8B7YAU3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Triosephosphate isomerase</fullName>
            <ecNumber evidence="8">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022090364.1">
        <property type="nucleotide sequence ID" value="XM_022234672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAU3"/>
    <dbReference type="GeneID" id="110979122"/>
    <dbReference type="KEGG" id="aplc:110979122"/>
    <dbReference type="OMA" id="IEKNGTM"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090364.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="26962" checksum="EE33AD78071E8836" modified="2022-01-19" version="1">MASSRDFFVGGNWKMNGSKDSINEILHFLKEAEVPENTDVVVAPPAVYLSYVQERLPAKISTAAQNCYKVDKGAFTGEISPAMLLDLGLSWVILGHSERRHVFGESDQLIGEKVQHALSKGLKVIACIGETLDQRQKGQTQDVVYHQTKAIADNVADWDQVVIAYEPVWAIGTGVTATPAQAQEVHEQLRGWLAENVSAAVAKKTRIIYGGSVNAGNCQELAAKTDVDGFLVGGASLKPDFVKIINAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAW7</accession>
    <name>A0A8B7YAW7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Cation-transporting ATPase</fullName>
            <ecNumber evidence="24">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC110979124</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine. Also stimulates cellular uptake of polyamines and protects against polyamine toxicity. Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Contributes to cellular zinc homeostasis. Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress. Required for proper lysosomal and mitochondrial maintenance. Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels. Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Promotes secretion of exosomes as well as secretion of SCNA via exosomes. Plays a role in lipid homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>spermidine(out) + ATP + H2O = spermidine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>spermine(out) + ATP + H2O = spermine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45725"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="23">Interacts with MYCBP2; the interaction inhibits the ubiquitination of TSC2 by MYCBP2. Interacts with HDAC6; the interaction results in recruitment of HDAC6 to lysosomes to promote CTTN deacetylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Endosome</location>
            <location evidence="22">Multivesicular body membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Membrane</location>
            <topology evidence="24">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="24"/>
    <dbReference type="RefSeq" id="XP_022090368.1">
        <property type="nucleotide sequence ID" value="XM_022234676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAW7"/>
    <dbReference type="GeneID" id="110979124"/>
    <dbReference type="KEGG" id="aplc:110979124"/>
    <dbReference type="OMA" id="DQDSYKF"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903543">
        <property type="term" value="P:positive regulation of exosomal secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905165">
        <property type="term" value="P:regulation of lysosomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010821">
        <property type="term" value="P:regulation of mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900180">
        <property type="term" value="P:regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000060">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000026">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000045">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12 24" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 24" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
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            <end position="207"/>
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    <feature type="transmembrane region" description="Helical" evidence="24">
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    <feature type="transmembrane region" description="Helical" evidence="24">
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            <begin position="389"/>
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    <feature type="transmembrane region" description="Helical" evidence="24">
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            <begin position="426"/>
            <end position="448"/>
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="899"/>
            <end position="917"/>
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="923"/>
            <end position="940"/>
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="960"/>
            <end position="985"/>
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1005"/>
            <end position="1028"/>
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1040"/>
            <end position="1060"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1080"/>
            <end position="1101"/>
        </location>
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    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="27">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="26">
        <location>
            <begin position="151"/>
            <end position="208"/>
        </location>
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    <feature type="domain" description="P-type ATPase A" evidence="25">
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            <begin position="249"/>
            <end position="375"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00006000"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    <sequence length="1137" mass="127063" checksum="FB406A3603218AD3" modified="2022-01-19" version="1">MAGRTNNKKAGLEIQEGKDDAFVCYGYHRSRAWTWLSYTLCVCTVGLAALVFYWKPDWWIKFTCRVCDLRDADSIIIKDIYQRYHVCPLRTMEVNSKSVCGPKSLKKLLHRDVVIGGMLKYVKFQKVRYMWDPKEETFFKLRVLDGANSCSEFYDKLQNGLSEKEANKRRFLYGDNKIIIRVRPIIVLLIQEVLNPFYIFQLFSVALWLSDNYYYYSGCIILMSAVSITVALYTTRKQSITLRDMVESNTTVEVLRKSGACIKVPEDQLVPGDVMVLPPEGCVMTCDAVLLTGNCIVNESMLTGESVPVTKTPLPCAMGSDGEEDSGYNADKHKRHTLYCGTHIIQTRYYGGEMVKAVVVRTGFSTAKGNLVRSILYPKPMDFSMLKDAILFLCALATFAVIGIIYAIVVFVNFGNDGSYIVRRALDVITIAVPPALPASLTIGMLFAQLRLKSKGIFCISPQRINTCGSLNVVCFDKTGTLTEDGLDLMGVQLAGSGIFGELKTSVADDTTGHHLAAMATCHSLTIINGELSGDPIDLKMFQATGWDLEEPTSKETTNFDILVPTIVRSPLKTDEREIGVLRQFPFSSDLQRMSVITRTLSEETMRLYVKGSPEMIASLSKLATIPANFQDQLNSYTQDGFRVLALATKELDPNLTWHKARQINRSQVENDLIFLGLLIMQNKLKPETKPVIQELQAAGIRTVMVTGDNILTAINVARKCDMIPAGEDIVRVEVEEDNEGNKLRLTRLTGCKEKKTIGQDHLDDGDCDEIHLQIESTVGRRTHYAIDGKSFKAVRGLNTDALATLAVQGTVFARMTPDQKAQLVESLQDLEYRVGMCGDGANDCGALKAAHAGVALTETEASVASPFTSKIQNISCIPTVVKDGRAALVTSFGMFKFLALYSMIQFITVIICYSFHSFLSDFMFMYADIFVCTTVVLFMGRNDAYHVIAPKKPPSKLAIFPVIFSVITQVAIQAACQVAVFFILQEQPWFVPLVPEQNSKNLVAWETTSVFLVSMFQYSTVAIIYTPRKPYRRAIYTNYLYLVDLIIIHACSLVILFYPPTAIEDLFKLKHIPSFRFKGIIFGVVLLNFILSALVELVLVSSRTLMGFLSCKRFRKVSLPTYEEFKIKPIRLSDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAW8</accession>
    <name>A0A8B7YAW8_ACAPL</name>
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        <submittedName>
            <fullName evidence="9">Adhesion G protein-coupled receptor F5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110978283</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_022233159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAW8"/>
    <dbReference type="GeneID" id="110978283"/>
    <dbReference type="KEGG" id="aplc:110978283"/>
    <dbReference type="OMA" id="ALIMCIN"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2-like_7TM"/>
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        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
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        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="536"/>
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            <begin position="300"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="584"/>
            <end position="600"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022088851.1"/>
        </source>
    </evidence>
    <sequence length="609" mass="66516" checksum="A8FB6300A9D7CF8E" modified="2022-01-19" version="1">MCNGKSPIAESSCNDQTCQDFCDPWPWGGCSSICGPIDKIFTIEVFFEFASSSSASGMSCSERQIYDPFLGRCRVLTCAAGFQIAGDECVIEDRVSDTPMSNTINCLSETLGIGTSSVFTSEHQHEAPDPNATAQSLYIVMLSATYISDFELAFDKAVEAIGFDPHESPLLCNISQVSLLLPFALNISNHCINSTVDGSKLIPVHNDTLMKVLEYNANPIDQKYSKLKASLICLKILDLNCSSLLFLDHLEYHIVSNSTIKIAASGSWLSDGEYVLFPDGIAVVCSFIGPTPEGLEPYIRRVISFVGSCLSLFALAATFVTYCVFSELRSLAGKLVMNLTVALFTAILMFLVPGYLAWNPTACVLGAVLAHFAWLAAFTFMTVIAVNVERSLTSLIQRKELSSGVNWTLVAYMTLAWGMPFAIVVICLVLQYCDCTSLPVIYSEGAVCWITDATVRLVVFVVPVGISLVSSTSLYVVTVVRLRQRRRATQIVRRQGRIEGATKEVAIYSKLCTLIGVTWLFGFVSQSVTGILAFSYIYIILNYLQGVFIFIAFCLNKRVRGLWKEKLEGPKEKPKKGAPSASKNNTHGSNTPATISSVSALNVPEDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBI7</accession>
    <name>A0A8B7YBI7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gluconolactonase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110978782</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022089750.1">
        <property type="nucleotide sequence ID" value="XM_022234058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBI7"/>
    <dbReference type="GeneID" id="110978782"/>
    <dbReference type="KEGG" id="aplc:110978782"/>
    <dbReference type="OMA" id="LWRCRAD"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000027">
        <property type="entry name" value="Regucalcin homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008367">
        <property type="entry name" value="Regucalcin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF47">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01791">
        <property type="entry name" value="REGUCALCIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="16">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022089750.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33567" checksum="323FC71C648154AD" modified="2022-01-19" version="1">MASPEQVKIEVVVKNCGQLLEGPHWHAASQTLYFVDIYGNAVHRYRPADDRHEKVDVGENAGTIVTTASGKLVLAGKCRFSYLDWSTGALTTITKVDEDKPDNRFNDGKCDARGRFWAGTMGPEERPAEVRRRQGSLYCLHSDKSVTKHAKDLDISNGIAWSLDNKIMYYIDSLTGLIEAFDYDLETGKTSNRRAVVSVPKEEGLPDGMCIDHQGMLWLACFSKSRVNRYNPETGEKLQTIMFPATNITSCCFGGPNLDELYVTCSRMGISDEVVRNEQPLAGSLFKVTGLGVKGFASMDFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YC28</accession>
    <name>A0A8B7YC28_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110978499</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089241.1">
        <property type="nucleotide sequence ID" value="XM_022233549.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089242.1">
        <property type="nucleotide sequence ID" value="XM_022233550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YC28"/>
    <dbReference type="GeneID" id="110978499"/>
    <dbReference type="KEGG" id="aplc:110978499"/>
    <dbReference type="CTD" id="4800"/>
    <dbReference type="OMA" id="VAHMIRV"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="314"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022089241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022089242.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="40378" checksum="4DBD813A7F468A5D" modified="2022-01-19" version="1">MSTVQNITTQAQPVQIQVAQSGQQQQPQVVQVGGTGQIMASGQPITIQLAGGQGGTVQLQQVGQMLQVTGQNGQVQQIQLVQQPQQVQLQQQQQATTTTQQQPQQQPQQQPQQQQAQQITVQQQPQSQPIILQASQQQVASQGGGQSLQLQQFVTPDGQTILYQPVTNTDSTVGLQQTNQTTTQNANSIMTAMPVNSDGGIVMMVPGTGGVSTMQRIPLPGAELLEEEPLYVNAKQYHRILKRRQARAKLEAEGRIPKERRKYLHESRHTHAMNRVRGDGGRFNTGSRGVATNQSSLEESPTMVPRSKFPQGENVSQQQQFSVNNQAGNSDSDSSLNINLDMLSDSPQIGANNQSLLEPSPNVTTNGTTNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCB3</accession>
    <name>A0A8B7YCB3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110979417</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090883.1">
        <property type="nucleotide sequence ID" value="XM_022235191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCB3"/>
    <dbReference type="GeneID" id="110979417"/>
    <dbReference type="KEGG" id="aplc:110979417"/>
    <dbReference type="OMA" id="DLVRMPC"/>
    <dbReference type="OrthoDB" id="10262359at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF25">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN DDB_G0277895-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="8">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="8">
        <location>
            <begin position="139"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="8">
        <location>
            <begin position="215"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="8">
        <location>
            <begin position="283"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090883.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="53227" checksum="56ECC228705B1F97" modified="2022-01-19" version="1">MKNSEQPSLASWMPAGAYPHHGQAYRPMASSQQPVHIQGVSTLQRFAIQRKSLLEAYIYCFLFGLFGVHHFYLKRNLLGWLYLFSLGLLGVGWLIDLIRLPWLVAKANQEEEEMVRNGYCVARQYNYRFYDLRERTLLEAYIMWFPMGLFGFHHFYLGRTGFGVIYAFSAGLAGIGWLTDIFRMPYLVRETNEKIRKLRNGEVVEITMECSVGDAYQLAFPLGILGLHHFYMGRVGQGLAYLCTGGLAGVGWLADLVRMPCLVSRHNREVQENRTWTRHLDDAYIYAVPFGILGFHRFYLSGPAIGLLYFFTAGIFTIGWLVDLVRMPCLVQAANKRERLRCEMYTNLVIPNNERLYVFIPGQGTPGHGQGQPPLSYGTANQTHNAQLPYATQQGGLPYYLNQNHHMPVPANPVLSPYGVPPPNPPQYEGIAEPEPSPLPPPYQETSDSSCQQTMATPAPPVESKFGESQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCD6</accession>
    <name>A0A8B7YCD6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110979055 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110979055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090232.1">
        <property type="nucleotide sequence ID" value="XM_022234540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCD6"/>
    <dbReference type="GeneID" id="110979055"/>
    <dbReference type="KEGG" id="aplc:110979055"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035:SF109">
        <property type="entry name" value="PROTEIN DRAPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034312319" evidence="5">
        <location>
            <begin position="21"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="6">
        <location>
            <begin position="25"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022090232.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="50200" checksum="9C00D41473A78BF9" modified="2022-01-19" version="1">MDPVAHVTLLLLISTNLAFSQELTGPNVCAESVTRRKTKQVEHTTYTYNCQLGQQTCSVTRSITVYYTDYESRQICCKGWLRNESNCLTPCPLKTYGQNCTGTCDCTSANSHCDPINGCSCDTGWKPPNCSEPCDSYTYGFACAKNCTCLNEATCDPVNGSCSCTPGWMDPDCSKACPADRFGANCLDECSCDTGVTCDRVTGNCTLLEITSAVPEATNDPTEAIITLVYADNGIDEGRIHFMAARLAATIALIVGCIVFIVAVVGASLYFISKRVFKTIRARNSADPEERNCNSSQRPEDQCEESVIQPSQPAPNSSLEEDESDVNEPSLGNAVDEAATLANVNGHAEGTEAATSEAAIAEAEPVADGLPRAGTVRRNKRDELPPTLPRPKCSWAEDENAYCELGGGPEQNQTLASKPKPNVKPRRFTRKPSSTTRTETAGNEASNKREDPLYHVLNPDQSGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHG5</accession>
    <name>A0A8B7YHG5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U7 snRNA-associated Sm-like protein LSm11 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092689.1">
        <property type="nucleotide sequence ID" value="XM_022236997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHG5"/>
    <dbReference type="GeneID" id="110980375"/>
    <dbReference type="KEGG" id="aplc:110980375"/>
    <dbReference type="OrthoDB" id="10002367at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005683">
        <property type="term" value="C:U7 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071209">
        <property type="term" value="F:U7 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01739">
        <property type="entry name" value="LSm11_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039267">
        <property type="entry name" value="Lsm11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034109">
        <property type="entry name" value="Lsm11_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21415">
        <property type="entry name" value="U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21415:SF1">
        <property type="entry name" value="U7 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092689.1"/>
        </source>
    </evidence>
    <sequence length="549" mass="61840" checksum="6DA26A91F1F176EB" modified="2022-01-19" version="1">MRVENMSDPNSEDESGETNLLSPNFNPLKALYSSGVQLPFPGATIFNNLFEYERITAARNRGDCSYVSASSHGSSADGNSGRSLPSSQGKERTVQESYQTGSISRTRRQKEQVPLGRGFRATQEMLIDTAKNKPRTFRNVLTRMSEYSSGPLSMLYRCMNERCKVRVCTRSFKGLRSICTGYLVTFDKFFNMALTDVDEVWRRLSTGQRFYHEETVTFSKIMDCSRTLESADSGQMDKSGTKETKEIAQLKEAGTSSQKKPQTSEHLYQDKHTKDSSSVLEREDRRHSAKDVPSESHQEDGRRSEKSKHRGLRQHRQKEERPSKTREGKERQKSSHRNSPGTKERTKKSSPEPDKGRSDDEDIEDLQQRLAALQRELTSLSADDEKAGDTGISEHLAAVHDFGSSSEVKTEGSAQLKEVDEVRGVIRTTRRDSRSQDRISQHPEQVRTSAEGPKEVQGQESGQRAKGDRKDNFNLAGETRDQPSHSTSTDTNSKVKPIEKKDSAAVGVKIKKGRLQIKAEEFQRRHVNQLFIRGDNVVLVSVDSILLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YI79</accession>
    <name>A0A8B7YI79_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Regulatory-associated protein of mTOR-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110980200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092317.1">
        <property type="nucleotide sequence ID" value="XM_022236625.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980200"/>
    <dbReference type="KEGG" id="aplc:110980200"/>
    <dbReference type="CTD" id="57521"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000065">
        <property type="entry name" value="Regulatory-associated protein of MTOR, complex 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000072">
        <property type="entry name" value="Regulatory-associated protein of MTOR, complex 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="5">
        <location>
            <begin position="50"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="723"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="859"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="908"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="729"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092317.1"/>
        </source>
    </evidence>
    <sequence length="1350" mass="150732" checksum="03B11C016E4AA2D5" modified="2022-01-19" version="1">MDGVGDIIITDVEDSDLCDWQLPLAFMKKRHTEKIEGSKTETQTWRMKERMKTVSVALVMCLNVGVDPPDVVKTSPCAKLECWIDPLSTSPQKALEAIGNNLQKQYERWQPRARYKLCLDPTVEEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTTNGEIWVFNKTFTQYIPLSVYDLQTWMGSPSIFVYDCSNAGLILESFEQFALQKEQEREVKLATINSHTLSSSQPPIPPPAKNCIQLASCGPNEQLPMNPELPADLFTACLSTPIKIALRWFCFQKSSELVPGVTVELVDKLPGRLNDRRTPLGELNWIFTAVTDTIAWNVLPRELFQKLFRQDLLVASLYRNFLLAERIMRTFNCSPVSSPRLPPTYQHSMWQAWDLALDVCLAQLPGLLQGEEYVHSPFFAEQLTAFQVWLTMGSEKRDPPEQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDRSCKADLVKDNGHKYFLSVLADPYMPAEHRTMAAFVLAMIVEDYPNGQEAALQGNVIAICLEQLNDPHPLLRQWLALCLARVWTMFDAARWCGVRDSAHEKLYKLLSDPLPEVRASAVIALGTFIGNGTERTDHAINIDHNVGMTLINVVQDGSPIVREQLVVALYQLIKQFESQFASVARQILEEDQRSDENQAPLGVGVTTGGWLLVHDSLGANAAQGHAASMRRMSLQQGSAASSSRRTNQHLPHSTSAGNLQMYAQQLARSPSSSSSSSSTNGPTTSSGSGDAYPVNGPVLFDKARRLSPGVNNLFSSSYNNVYAQIWKTMLTLASDSLPAVKRLAQQLVNQINLKATVMAKPQHVLQENRRTPSSAPNSPSTRNHSASPQNLSDSPPPAVLNIPIEIVKPVPIRAGEQPPPARPQNPAPIGSQFPHSQQFTRVRKLFDKGPSITYEDMESVNISTKDLNLSTNFSNWCCKYFAQSVMRAPEEMDPYSSLHQEREWRFLRNAVARKEAREQQQRAVMSRLDDQIFINRNQGIPVALRFQHFSPHVIVADKEGVCVWNWENGEKLNYFSHLNHKDTKITSMDIMNAHDISLLMTGCDDGAVQIWRNYLPDSSGPVELVSSWHALSDMLPSIKGAGLVLDWEQESGMLLASGDVRTIRVWDTQRELKLQDIPTGADSCVTSLACDSVGRSLLIAGCGDGSVRLYDRRLAPTESRVMTLREHNSWVVNVHLQKGAGDGKIISASVNGDVRFWDPRFTESVKLIQTNFSLLTTMAVHQQANIFACGSANQLISVFNMSGDTLSNIKYYEGFIGQRIGPVSCLAFHPLKVYLASGSRDSFLSIYSTEKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIP5</accession>
    <name>A0A8B7YIP5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Retinol dehydrogenase 14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC110980596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093124.1">
        <property type="nucleotide sequence ID" value="XM_022237432.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093125.1">
        <property type="nucleotide sequence ID" value="XM_022237433.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093126.1">
        <property type="nucleotide sequence ID" value="XM_022237434.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093127.1">
        <property type="nucleotide sequence ID" value="XM_022237435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIP5"/>
    <dbReference type="GeneID" id="110980596"/>
    <dbReference type="KEGG" id="aplc:110980596"/>
    <dbReference type="OMA" id="FHWYGRA"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022093126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022093127.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30323" checksum="197E1516364B174E" modified="2022-01-19" version="1">MSAASMVGRIILVTGASDGIGKHTALKLAQMGATVLMHGRNTEKIHHAKREIAEKTGNKTLEVYTADLASLREVHHLSEDIHSKYSRLDVLINNAGVYMLNREESKDGYEMTFAVNVLAPFLLTSLLLDLLKAGKSSRIVHVSSISHLNCNKVNLDDLNSKLDYRDGRPAYALSKVCEIMYTYKMAELLQDANITVNCLDPGTVNTNMLLKSWGPVGIPVGEANFVYQTAADPALDGVTGRYFVDNKDTKSSAISYDKTLQDKVWDILVKLTGATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIY3</accession>
    <name>A0A8B7YIY3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC110980632</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093196.1">
        <property type="nucleotide sequence ID" value="XM_022237504.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093203.1">
        <property type="nucleotide sequence ID" value="XM_022237511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIY3"/>
    <dbReference type="GeneID" id="110980632"/>
    <dbReference type="KEGG" id="aplc:110980632"/>
    <dbReference type="OMA" id="RINYKPW"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000001">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140914">
        <property type="entry name" value="PriB N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="13">
        <location>
            <begin position="296"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="475"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022093196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022093203.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="63182" checksum="BDA7CF51B6776F7B" modified="2022-01-19" version="1">MQFGGERKNALQRQQRGRNKGQVRSSAGFGMFGQYSHRLQFYRLPPTDNISLNEFEEFAISRVKVLRHVEQAGQSYVKGTDKYKEYMDRDLRHLMPVAVRKDLKDDFEERRKDHISHFILRLAYCKSEDLRRWFIAQEMDLFRYRFLMETDKREVARFLQENDLHFTPIPDEEKRQVAKYLCASSYSMSMAMIEHTDFYKVPFTEALDLVRARKIYVHKGWAYVPHNDLVSIILSAFRAHLSQALAVTARSIPHLEEDDRLLPMLNNLSKQYLGQNYSSGKSNMGKIELKDMDMHARKSFPLCMRQLHSAFRENHHLRHHGRMQYGLFLKGIGLTLEQALTFWRSEFSKIMDVDKFEKQYAYNIRHSYGKEGKRTDYTPYSCMKIIMTNAPATGDHHGCPFRHTDSNLLKQRLGAYKVNQSGIDEIIDLVNKSHYQVACSKYFMLTHGNAKSDVAIQHPNQYFEESQKILTGDKKYEGSGRYTSSRPQSQAAQSPRVSSHQATLDPSTQTSSSVQDQFEDELNLSFEELEAMEKEAMEGATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKB3</accession>
    <name>A0A8B7YKB3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytosolic Fe-S cluster assembly factor NUBP2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110980927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. Interacts with NUBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093699.1">
        <property type="nucleotide sequence ID" value="XM_022238007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKB3"/>
    <dbReference type="GeneID" id="110980927"/>
    <dbReference type="KEGG" id="aplc:110980927"/>
    <dbReference type="CTD" id="10101"/>
    <dbReference type="OMA" id="WIPVFAD"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000796">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03039">
        <property type="entry name" value="NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028600">
        <property type="entry name" value="NUBP2/Cfd1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022093699.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="30219" checksum="73E7D755C5A2D3DF" modified="2022-01-19" version="1">MEASIGNASGNTEERHNLESVKHTILVLSGKGGVGKSTVTTQIALALRQNGLKVGVLDIDLCGPSIPRMLNVQGKDVHQCSRGWVPVYADMEQRLAVMSIGFLLGGSDDAVVWRGPKKNAMIKQFLSDVFWSDLDYLIIDTPPGTSDEHITVVESLHQYRPDGAILVTTPQAVAVGDVRRELTFCRKTGIPVLGVIENMSGYVCPHCSECSNIFSKGGGELFAREFSIPFLGCIPLDPQLTRCLEEGKSFVDCFPTSPSVGAIQDIVKTLLQNNSLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKQ4</accession>
    <name>A0A8B7YKQ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NFX1-type zinc finger-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022092111.1">
        <property type="nucleotide sequence ID" value="XM_022236419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980087"/>
    <dbReference type="KEGG" id="aplc:110980087"/>
    <dbReference type="OMA" id="MEENAYT"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="8">
        <location>
            <begin position="1233"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022092111.1"/>
        </source>
    </evidence>
    <sequence length="1327" mass="152325" checksum="3D75288FC7788566" modified="2022-01-19" version="1">MEGNPFRVRGFRANQGGAPARGRQQEDGQARHQGYQRRVDNQHGQERGRGGYGRGRGQERGRGGGYFRNAGQHHQEGGAKQRERPVRQPGYKMLESLLDEEKCAAEVVQELTSFGKGLESLLSERDIRRDMMALLVRVLGRVCDCEDSPQSVVRVLNVVVDTDFLSKNLSQHINSMVTEFDERYLRRVPNQIASILKLMQTLIQRIQNTMKDVHVVLTLMDVVTRTLETKGYPLESESKVLLSQLLLCCEEREKAKKHKSQRQRTDQEAPPPNDFREIPIFPDVAEITTNAEAYLRANVVHGKYRDLNHYLDVQFRLLRQDFLEPLQQGIAEYHVSLAQTNMNRKLKDIRIYHDVGVHFPICTNDGITHRVSFDVSKFRKVRWQATKRLTFGSLVCLSKDNFQSVIFATVANRKPEELEQGLVDLRFQDMTRVSEINSTDSFIMAESSAYFEAYRHVLQGLQEVRGNSLPLQRYIIEVSCDVKPPQYLRHDRFSTYDLSPLTHTAEEVDKDDESKLLSTLRRVSTKASAVQVLTPSTWPQAETLHLDDSQLQAVKAALTQELAVIQGPPGTGKTYIGLKIVQALLYNSDVWNEDEESNPILVVCYTNHALDQFLEGIMKFNQNIVRVGGRSNSEDMKNKNLNFLKREQRRRRDVQRTVHIRTSNILREMYSLRQCMEVSQRKVERSMNGIINEDYLQPFMSKEHYATLTVEFVETGFHRPTPCILEWLGLSGHFRVATAQEVGMAAFMGEENEPEEPEEEEQEEEEIEVAEEADAIADQRVLDDDDEDMFLFEEDPQENHLVLDIEQLAAAQPLEEGWQMQPHQKKRMRKMLLHNLRKSDRMTERDAQRIKNVWAMRDINSRWQLYRYWVSEYCKNERKVCGHQCTALCTRECPPCAQKCQNQCVHSKCPNRCGDPCTPCQEPCPWRCPHYRCRKKCSEACDRPPCNRPCPARLRCGHPCIGLCGEPCPDKCRVCHRDEVTEIFFGSEDEPDARFVQLEDCSHVFDVDGLDQWMQVTNEGQKSIQLKVCPRCKTPIRRNLRYGKIINETLADIEKVKERIFGNKQEIEQKKIKIRVMLYSVKAEVDTLKDRVKHSKLGLAELIAIENQLLLLEGISKLKRKAEEARNAPKSITELRMQKRNLVELEQWLLKPRIYVSQQELDDCSREVQRLSMCFSFFLIKERLQSSASTCSTASLTVVEKLLLSGQPLDDSSVNTAKTLLEKLRKQCTGLGISESERIMIVKAMGMSQGHWYKCPNGHCYAIGDCGGANQESRCPECKAKIGGMSHRLAEGNAVATEMDGARYGAFSDQANMDNYDPVQLQNLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMS9</accession>
    <name>A0A8B7YMS9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UPF0547 protein C16orf87 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110981367</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0547 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094573.1">
        <property type="nucleotide sequence ID" value="XM_022238881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMS9"/>
    <dbReference type="GeneID" id="110981367"/>
    <dbReference type="KEGG" id="aplc:110981367"/>
    <dbReference type="OMA" id="HCPECEV"/>
    <dbReference type="OrthoDB" id="5981040at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040246">
        <property type="entry name" value="C16orf87-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018886">
        <property type="entry name" value="UPF0547"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31101">
        <property type="entry name" value="UPF0547 PROTEIN C16ORF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10571">
        <property type="entry name" value="UPF0547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0547" evidence="4">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022094573.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="25146" checksum="E4109C0199F51ED0" modified="2022-01-19" version="1">MLSCWSCSGKDARPKLRFRWSQAKVRPTRDFRCPFFYKMVLKQCPHCDQQVPVACKACYCGYEFFQRRMYHAKVEQSSDQNNKNRRTGRVKRERPDYYSASEFETHLRRLSNKSERSGNTPPKSPKKKHRGRPRKKGSTLNKTAKTKVKGEGSSTETKDSKEEDVYSNMSAENAFVYMVGLAEINRKLQSQWNGPSAEPGRDAKKENSQYVFCEGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YP90</accession>
    <name>A0A8B7YP90_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein LOC110981206</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110981206</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094265.1">
        <property type="nucleotide sequence ID" value="XM_022238573.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981206"/>
    <dbReference type="KEGG" id="aplc:110981206"/>
    <dbReference type="OMA" id="NTSPCDT"/>
    <dbReference type="OrthoDB" id="6158730at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000027">
        <property type="entry name" value="Thrombospondin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 10" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2098"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="18">
        <location>
            <begin position="516"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="567"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="16">
        <location>
            <begin position="609"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="19">
        <location>
            <begin position="1037"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="17">
        <location>
            <begin position="1197"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="20">
        <location>
            <begin position="1359"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1724"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="14">
        <location>
            <begin position="1935"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="2048"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="59"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="186"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="401"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="410"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1759"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="2052"/>
            <end position="2062"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="2056"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="2075"/>
            <end position="2084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022094265.1"/>
        </source>
    </evidence>
    <sequence length="2203" mass="239063" checksum="15B559AA89C54ACD" modified="2022-01-19" version="1">METTSEDLTSTVTTGISETPISSTTAPVDTTTEDFQFTVSTTPLETTVSSTTLTVETTSGDFQSTVSTAPSETTASSTTLTMETTSEDLTSTVTTGISETPISSATAPVDTTTEDLTSAVTTGVSETPASSLTPTVDTTSEVLTTEVETTTSSASLTVETTSEVSTVPSGTTVLSTTLTMETTSEALTSATTSGISETPTLSGTPPVDTTSEASTAPLETTVSSTTLTMETTSADLTSAATTGISETPISSATTPLETTTEESTSMMTSVVFETLTSSATPTVETTTKDSESTVSTSPSKTTASSTSLIVETTSKDVTYATTTGVSKTPISSGTPPAEATTQDFQSTASTAPSETTSSSTTLTMETTSEDLTSTVTNVVSETPIFSAPSTVETTTKALTSTVTSGVPETPTLSATPPVQKTTENFQSTASTAPLETTASSRTLTVETTSEDIKSTASTQRAGTTPSLHTSPVPTTTGTTTEAKPTCAPGEFDCGQLVCISGLFQCDGNRDCEDGSDEDNCVGCRNYCFQEEPRGDCYCDASCEKFGDCCEDYYEYCTLPAYTTKSPGVNECDPEKPLHDCNENAFCTDTPEGFNCTCNEGYEGNGKSCNDIEPPRIDCPANFTEYTDCRKENSTISLPNVNSASDNSGEYTIRVDVQGKEYQVGDTVTLALEGSPHLLRYIATDDSSNRRACDSFVNVTSVNDGSSCLTTGSPPNCICSSNQEGSCTCSAGYCGHDCSQNDVGTLCTGPKEPYPNCEGVNKCSPGFTGPTCKEPSSEINCPEVANQCLKWGVNSVSIQWTQVKAVDSSGNPISPADITCQDVKGATSVELTGGEFKIGEHEVVCSSDTGGVVVPVCLISFTVSSNPTFKVPEIGDQCTDLGKSTSNVTWDIVPAADEEDVTIICTGSEGSTDVGPTGGVFKVGAHTVTCTATNSGGCIKSKIFGFSVLEGNIIPFGVEMGDSLLSDAFQENQQTSKDLISPTIFPPNFFPFCDELYESLYFTDNGVIVLSNDKSLEKWAFPNIPGLQFPNGPPMIAPFWADVQAETFSPESNVFWQVYDQYDPNTNQYMLDTIKDIVSKVVDIRNNTNAVYWALAITWSNVQPVSSSYASGTNTFQVLLLTDSIHSYVVFNYGPCNMNWDTAFLPNKNVILGYTCGMSKESVYLDVPKNSLFRPGSFVGNSGQKGRWVFQLDNHLDDFVNPRLSCRNWYSRQAPYPIFDVYYPSFANTCPCSLIMAWFDWRFLLTWRQSYIPPGEVSEYFQDQSVLCFVRLFQLSGTPGTQCCYKRWTGDLLYDVRSPKVASVFERFPYSDLFYTADAFQEWYEEEVLSRYYCCEKSTLCHLYIEWRPLVTCSRYFPTFWGWFWGDPHVRTLDGVDYTFNGLGEYTLVLIEDENRKEKLFELQGRTKRVYNPEMGELTNATSYSGFAAEDVASDGRVEIKLNEQATNLITTVNGEVVEPTAAGLVISGLTVRKVEDPPKVEAIFASDIQFSVGVNNSFVDVTVQLSQDFEGKTKGLLGVWDGNKTNDILRRDGTYQSPSGSNGTMLENDYFEFGETWRVSVNDSLFYYQSPEESWEKINDLSFRPKFLDELLAGVSEEERQQIKEVCGDNKECIYDALTLNDTDIGIATLQLNEKNSEDLKSATNYPPELTQFETIEVTVGQNFTQQIDATDPDGDEVAIYLLEAVEGASIKDGLFNWTPADKSKVRIGFLASDGKANSSLEPIVNLCDCKNDGTCLLNQYAEGTNLIQDRFGVLLCQCTSGWTGEFCQVDYNACAVSPCFSEVTCTDETPPSLNSTCGPCPDGLEGDGKTCTDIDECERYKDDPARGCEQICENTLRSFNCSCNSGYFLKEDKKTCRALSATDCLNEGEFDESSHECICPLTHYGPTCADENPCLSDNTLCSEEGQHCLPESNTVGFACYCRGFDGYVEITLDGSCEAYASVGVMLTAKMEFVIAYKNPTSTAFNKTAAMFERAIQERLQEMPSTNNLVKIQVTRMDEGSLIITAVVSYGTIPSLDEVKKVLSSSDSLTDGNTTIPIDPDSVRVQKLSSDCLLECLNGGTCERPDYSPIDSCRCSPGYAGDRCETGVEPVPDGLPTVALALIVVGCILFVLVIIPGVIYIVMRKNFRKKVDKVVDGEESRVQEDIRELSLHGELFNDGYEATEFSEEGIRMEYLRRGMPATELKRTKNQNSYIPSFHRNDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQM3</accession>
    <name>A0A8B7YQM3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Heparan sulfate glucosamine 3-O-sulfotransferase 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11 12" type="primary">LOC110981885</name>
    </gene>
    <organism evidence="7 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095575.1">
        <property type="nucleotide sequence ID" value="XM_022239883.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095576.1">
        <property type="nucleotide sequence ID" value="XM_022239884.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095577.1">
        <property type="nucleotide sequence ID" value="XM_022239885.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095578.1">
        <property type="nucleotide sequence ID" value="XM_022239886.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095579.1">
        <property type="nucleotide sequence ID" value="XM_022239887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQM3"/>
    <dbReference type="GeneID" id="110981885"/>
    <dbReference type="KEGG" id="aplc:110981885"/>
    <dbReference type="OMA" id="HFKNWLE"/>
    <dbReference type="OrthoDB" id="10062788at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF72">
        <property type="entry name" value="HEPARAN SULFATE 3-O SULFOTRANSFERASE-B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="6">
        <location>
            <begin position="203"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="420"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022095576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022095577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022095578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022095579.1"/>
        </source>
    </evidence>
    <sequence length="474" mass="54410" checksum="1FD46AA4A5405A84" modified="2022-01-19" version="1">MSYISLKKKATVALLCLVSFTVGCILTTKLHSPQSFQMPSGLASLQASRLDLGKRIRGQRLKDNSKNVTESNADMYADHREASVDDERALTDQNETDIFTDYTYDTDKEAVSANSHAVAQPVSKHHYFVEVSDPRAGLILKKVISKLPRNLLRSVVFGKKIFDERELSLLGSKKAPTVSLQKKWAALTEGMREVGYEQRLPVVINIGVKKSGTNAFGFFISQHPQIVHSIGNEVHYFDWNYGKGIEYYRSRMGFSKANQFTFEKTPRYFITPDAPKNILKDLPSNVKFVICVRDPVERAKSDFRHEAELAMRRGKKDRVAVRTLARSETPASQGEKFEQTVLDKNGNINLSSDIISASVFSKHFKNWLEHFPRDRFYILSDEKVNKDIYTEMKNIENFLGLEPFFERNMFFYNREIHAPCMKVEPRPCPAKSTPGFLPKAEPSPEVIQKLRNFFRPYNQEFEKLTQMEFSWTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YS88</accession>
    <name>A0A8B7YS88_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110981197</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022094250.1">
        <property type="nucleotide sequence ID" value="XM_022238558.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094251.1">
        <property type="nucleotide sequence ID" value="XM_022238559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YS88"/>
    <dbReference type="GeneID" id="110981197"/>
    <dbReference type="KEGG" id="aplc:110981197"/>
    <dbReference type="OMA" id="RYQCNGK"/>
    <dbReference type="OrthoDB" id="21192at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF5">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="9">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="234"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022094250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022094251.1"/>
        </source>
    </evidence>
    <sequence length="679" mass="78142" checksum="E81AEBCA09EE78CF" modified="2022-01-19" version="1">MDKCVHIKKLRVTHNHSVFNPQKWLCKVCGTTESVWACLSCTNVACGRYNEEHALRHFQESKHPLAIEVNDRYVFCYECDDYILNDNAPGDLKLLRTTLDAITKQTLYESQTRSGRRLLRALSVDTGEQIKHRRQESLTWEDKGHTALVHRRLVLLSYVFLPWKQFVHGNKVTGQKPKPARIPQKRTRNTKTAKERDTPWAQGEAESGSKRRRLDDLRTQEVKRKWTALTPGVTGLRNLGNTCYMNSILQVLGHLHQFRECFLHLELNLRPLTSSQSVPGTRRQMEYMRQTTIECFEEVQKPKGGMRSKGRILRQPGTSYGGLSGGADETMDPSKYKDPRTVGNIFPLCHELHVLYRVMWSGKWAIVSPHAILSSVWRLIPSFRGYSQQDAQEFLCEFLDKIHTELQCVALSPLVRIASGASVPTKDIIGQSFEGGLVSQVTCLQCLQKSNTFEPLGDLSLEFPERYQFSEWRTSLSESNCHLTEMLAKFTEREHLGRVYSCECCNGRRRNAAAKPEVRTDATKRLLLTKLPLVLRLHLKRFRWCGRNHREKINVHVNFEEELNMRPYCYVGKEDESRLTNEDFVYDLTNVVVHHGRGFGSGHYTAYCWNSVGGFWVHCNDARLELCSIEDVTACQAYILFYTKRTSTVAHVGQPRDSTTEEDEVDGPSRPVRKRRFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSG9</accession>
    <name>A0A8B7YSG9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retinol dehydrogenase 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096229.1">
        <property type="nucleotide sequence ID" value="XM_022240537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSG9"/>
    <dbReference type="GeneID" id="110982242"/>
    <dbReference type="KEGG" id="aplc:110982242"/>
    <dbReference type="OMA" id="ARDINEW"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096229.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37284" checksum="31CECC90797AE19B" modified="2022-01-19" version="1">MAFDWQLYEDFSWKIYSGLAAVVCLCVYAFRRWNAPTFYRGTASLTGKTVIVTGSNTGIGYESALNFARRGGRVILACRNRAKGEEAAAKIRQLTGNEQVVFRLLDNACQKSVREFAKVILREEARLDILVHNAGVSRCHSNEKTESGYDLQFGINHLNPFLLTQLLLPLLRKTAPSRVLVVSSVAHKMVQRLCYLNTKQAWEETIAYSTCKLCNILFAAELARRLKGTGVTAYSLHPGMVDTRILHPRSSRFHGRLLLLFCRNVLRPFCISLEASVQTTLYCALDPSVTQHSGRYFADCRLAKESKLARDEKIASQLWDLSCKLTGTENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSJ2</accession>
    <name>A0A8B7YSJ2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110981806</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022095435.1">
        <property type="nucleotide sequence ID" value="XM_022239743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSJ2"/>
    <dbReference type="GeneID" id="110981806"/>
    <dbReference type="KEGG" id="aplc:110981806"/>
    <dbReference type="CTD" id="6470"/>
    <dbReference type="OMA" id="VTNRNAI"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF59">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="11">
        <location>
            <begin position="53"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022095435.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="55467" checksum="E8F1C565BF9C9D2D" modified="2022-01-19" version="1">MNGTAVQSSVNPSIAKRQKLSNSEEIQFDNMPANDATVITPGPEGWFGSEPLATNDPEIASIIAKEKDRQRRGLELIASENFTSRAVLETLGSCLQNKYCEGYPGNRYYGGTEHYDDLERLCIKRALEAYRLNPDEWGVNVQPYSGSPANFAVFTAIIGPHGRIMGLDLPDGGHLTHGFMTSRKKISATSVYFESMPYKVNPETGYIDMDRLEENARLFHPQVVIAGISCYSRNLDYARFRKIADQHDAYLMADMAHISGLVAGGVIPSPFDYCDIVTSTTHKTLRGPRAGIIFFRKGVRKTLKNGTQVMYNLEKPINEAVFPGLQGGPHMHAVAGVAVALQQSMKPEFKTYASNIIQNAQVMCKSLGERGYKIVTGGTDNHLLLLDLRPIDLDGARCEKILEDISVVCNKNTCPGDLSALKPSGLRFGTAALTSRALTAEDFEKVVDFIDRGIKLTKEVVAISGPTLKEFRETVATNEDVKKKIAAMREEVEAFATKFPLPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YV42</accession>
    <name>A0A8B7YV42_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Alpha-L-iduronidase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC110982461</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 39 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096555.1">
        <property type="nucleotide sequence ID" value="XM_022240863.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096556.1">
        <property type="nucleotide sequence ID" value="XM_022240864.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096557.1">
        <property type="nucleotide sequence ID" value="XM_022240865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YV42"/>
    <dbReference type="GeneID" id="110982461"/>
    <dbReference type="KEGG" id="aplc:110982461"/>
    <dbReference type="OrthoDB" id="15153at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003940">
        <property type="term" value="F:L-iduronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000245">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1500:FF:000002">
        <property type="entry name" value="Iduronidase alpha-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1500">
        <property type="entry name" value="Glycosyl hydrolase domain, family 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049165">
        <property type="entry name" value="GH39_as"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049167">
        <property type="entry name" value="GH39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049166">
        <property type="entry name" value="GH39_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000514">
        <property type="entry name" value="Glyco_hydro_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051923">
        <property type="entry name" value="Glycosyl_Hydrolase_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12631:SF8">
        <property type="entry name" value="ALPHA-L-IDURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01229">
        <property type="entry name" value="Glyco_hydro_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21200">
        <property type="entry name" value="Glyco_hydro_39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00745">
        <property type="entry name" value="GLHYDRLASE39"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01027">
        <property type="entry name" value="GLYCOSYL_HYDROL_F39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 39 N-terminal catalytic" evidence="5">
        <location>
            <begin position="36"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-iduronidase C-terminal" evidence="6">
        <location>
            <begin position="559"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600514-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022096555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022096556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022096557.1"/>
        </source>
    </evidence>
    <sequence length="650" mass="73528" checksum="C643A1A8A15EE6E4" modified="2022-01-19" version="1">MFFQLMMKLGTICLVSASFQLIMLAEFVSTVKYSFLVETDKAVAELNNFWASTGFCPPLPHQKSFEYFLSESELQNLILIGSVPHGGIQQVRIHWLLDLITLSVNSLTGQISLNFDLLDQLVDRLWSNGLRPGFELMGNPSNWFTDFEDTDQVYVWRDMVTALAKRYIDKYGLDYVAKWNFESWNEPDHKDFDNLNFTVQGFLNYYDACSEGLRVASPKLRLGGPAGACREPSFSVICWALLQHCENGTNYFTGETGVRIDFISFHHKGKGHSMYILDTEIQTIQRIQRLYPCLASVPIFNDEADPLVGWSKPEEWRADATYAAVVVKVIAHHQNLLIRQRPDVNYALLSNDNGFLDFNPHFFTQRTLVARFQMNETHPPSIQTVRKPVLSVMGLLALLGETQVQVVSDTGKGGNNSDVGILASVHHASAASGSHDSWQGSIIIYNSNDTSNLTGTDNITLTVTGVPTTNQLSMVYIVYLVDNTHGNPYRPWKAFGKPVYPTRKQFVEIRKHQDPLRIKGPNLFTAPKMTFNFNLSKPGVMLFHLCAKPSEKPPQVKSVKLHSVTQTDVLVSWEDVSSCCLLTYQVEFSPTKQGQYVQISDVDLIFTSYLYSIESANPSLRYSSTQGWYRVRAVDYWNRSGMYSTPIELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXN3</accession>
    <name>A0A8B7YXN3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110983274</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110983274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098093.1">
        <property type="nucleotide sequence ID" value="XM_022242401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXN3"/>
    <dbReference type="GeneID" id="110983274"/>
    <dbReference type="KEGG" id="aplc:110983274"/>
    <dbReference type="OMA" id="DCEEDLC"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF1">
        <property type="entry name" value="IP14385P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="4">
        <location>
            <begin position="69"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022098093.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39545" checksum="FB203FB572A6274A" modified="2022-01-19" version="1">MNDIGINKFLGPLGLHQYADIFQIKGYDVESDFCTLDKDDLDAMNITDTEHRETILQAATHYKPSEEFEVFQWLRDNGIDHYFGNFIRSNYTNLRQVSVMELTADVLHELEVLLPGHRKRLRNALPKLRKRRRIEEMEAEVPVAIGYWGKPAALEGAKYDFLCIQAALTSNKPNSLSFTEEFMVDSGSDVVTARQEILDQLDLELIGTIQSRGVHTTVEKQLYKAILRIGKQEAEIEVMPEPYESIGNRVMRQFRHVIDSTVHYWLQGNRLEPGESSGQASASALGSSSGEQTSHSTPELTGESGAESKEGSSPDELTKRKKTGQAKAESMGEEEREAEAEDSSSTSSAERSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY49</accession>
    <name>A0A8B7YY49_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110982924</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097415.1">
        <property type="nucleotide sequence ID" value="XM_022241723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY49"/>
    <dbReference type="GeneID" id="110982924"/>
    <dbReference type="KEGG" id="aplc:110982924"/>
    <dbReference type="OMA" id="ACNYSRN"/>
    <dbReference type="OrthoDB" id="10256523at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022097415.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="73444" checksum="99C33EE9CB43C42A" modified="2022-01-19" version="1">MGQPEKASVAQAEREIKDLRAENVKLKKELEETRSLYKQLVDEGPVECFDERRVHLLKSQVIQLERQVLLYSNALSSRTEVLLHVENCLQTIADQLRELVASEVKGPSVPVQRSQLTGLIETAEGARLRLFKNVEANNPDRLARPILYMGSFLKPAAEEDGVTLLDICSGKLEHLSLKQIAKLESKLFSLHRHLQALHQSLKVTWSRDHRLGLKTANHHLSLAVNQRMSGLLAQCEKSVAESCSDLLSVSILVPSAPWPLVIKPVSAELSLDSVMSALPSFPKSKQQQGRACVDALLKACNYSRNVAKLEAKACVSELHFHQKVYDVQSKYMESLFTAVREAYTEFEQNTHTLLCQPLKRILEAYSTLTSTTSEEALKDFLTTFKAEASELETVVEMLTVDRESPSSGQEALSTFGRDFFKSVDALVQQCADERDRLAEEIEAVKQMKEDHQKQGLKVFERPKPAPKSAKDEYEDVIKDTYETEPRADKGTAPDPGRTEANSTLDSGGKLATKSSAKVSKSTLESTTGSKIGKEQVDGKSRKGPRVLGKVGGTKDLDGILREAGRPRPPSALRGTLSPARRGTEGDSAPRSSQGASRIPRSGSTPRLKPPSPKQSPLSNRAQEGSKEVDTTPKSGLPHSPAGLGGVRRSASEGSRLSFKATGAKPGSQGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY72</accession>
    <name>A0A8B7YY72_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arrestin domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097440.1">
        <property type="nucleotide sequence ID" value="XM_022241748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY72"/>
    <dbReference type="GeneID" id="110982939"/>
    <dbReference type="KEGG" id="aplc:110982939"/>
    <dbReference type="OMA" id="TRRECNI"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="174"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022097440.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="48431" checksum="46D529CFC315C2F5" modified="2022-01-19" version="1">MGRLTAFEVVFDGDNVDVFSSGDVLNGYIRVVLIAPKDDIKAIKVKFKGKAHTCWTEGSGEDKESYTASEIYFNEKRVCWEKDDKTRRCLEAGEHRFPFSFKIPNIPLPFSFESSVGWIRYKVECKIDRPWKFNHHTERLFTVTGQPIDLTTMPNAMHPVRREDTKSVCCLCCETGPIITKASTDKAGYVPGETMYVSGSVENNSSREILHLTVRLKQLVTYVSWEGYTTRRECNIIKERAPGCGAGEVARMDWKPHVIPSIPPTGPQGCRIMRIEYVVHFEGDVENTPFDANVYLPITIGTVPVYRPPYQDPSGVVVQQPSSSGPPPPSYEIAIEGLQEVPSKSGYDYTFGKLMYAPQYPTYNLPAQPPAWDPMHPPPGQDPTYPPGGYPPPNDLTYPPAPGYPPARMQRYRYQPLSGGSVYPPPRVLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z069</accession>
    <name>A0A8B7Z069_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17">High-affinity choline transporter 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC110983419</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098356.1">
        <property type="nucleotide sequence ID" value="XM_022242664.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098357.1">
        <property type="nucleotide sequence ID" value="XM_022242665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z069"/>
    <dbReference type="GeneID" id="110983419"/>
    <dbReference type="KEGG" id="aplc:110983419"/>
    <dbReference type="OMA" id="IGHENMA"/>
    <dbReference type="OrthoDB" id="546820at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000008">
        <property type="entry name" value="High affinity choline transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022098356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022098357.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="60279" checksum="63B9547F560128EE" modified="2022-01-19" version="1">MAVNWGGVAGIVVFYLLILLVGLWASRKSRGYKDQEQTMLAGRSIGLFVGIFTMTATWVGGGYINGTAEKVFKPTKNSGLVWTQAVWGYATSLALGGLFFAKTMRSKGYITMLDPFQLKYGSRMGGLLFIPALTGDVFWTAAILNALGSTVSVILDLDMTLSVIVSACIAVCYTLLGGLYSVAYTDIIQLICIFFGMWLCVPFAMTNEVVEPIGSTASEWLGTIESHQAGLWVDSALMLIFGGIPWQAYFQRVLSCKTPGKAQIMSFVAAFGCIVMGVPSVLIGAVGASTNWNATTLDLEKTDPYRRSSIILPLVIQYLTPPVVSFIGLGAVSAAVMSSTDSSVLSASSMFTHNVYKLVFRPRASKRELAWVMRASTVGAGVIATVLGLSISSVYKLFVFCSDFVYVVLFPQLLCVIYFSKCNTYGSLLAYIVALVLRFGGGDHVLGIPALIKYPYYDEEEEVQLFPYKTLAMLSSLVTILVVSYSLDYLFKKGTIPKRYDFFHCFVNLPHAKLSQEEHSNHEANFDLKRCEPVVPSNLGGVCADEEVTYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0Y9</accession>
    <name>A0A8B7Z0Y9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Sialidase-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110983466</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098439.1">
        <property type="nucleotide sequence ID" value="XM_022242747.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098440.1">
        <property type="nucleotide sequence ID" value="XM_022242748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0Y9"/>
    <dbReference type="GeneID" id="110983466"/>
    <dbReference type="KEGG" id="aplc:110983466"/>
    <dbReference type="OMA" id="AWRFGEF"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628:SF30">
        <property type="entry name" value="EXO-ALPHA-SIALIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="SIALIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022098439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022098440.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="49708" checksum="EB79361676032264" modified="2022-01-19" version="1">MEADRRSDVKAPPLTEIFGQGDHGYDTFRIPAIVYNRRTFLAFCEARKSSFRDWGSIMDLVLRRGILKDDEVIWGDIQVIASIPEYRAMNPVPIVNKRNNSIVVVFVAFPQDLSEADLIKGQEYKQKVLVTKSRDNGLTWSKPRDITETTLGMMDPRPHIYASGPGHGIQLSSGRLVIPGNVFWKPPHEPGFLSELKHKILEFFDCFYNAQCRSMVIYSDDGGETWERGGSVPAAFDQDGQLVNANECQVVEFDDGRVYINSRTLGVQSPRQQAFSQDGCLTFNPGELATQLPEPGHTLTKWIPSVRNFGGCQASIFGFRAPRNVPPEAYDTGTWILFSNPASTETRVNMSVRLSRNGCRTWSTPWQLNSGASAYSDLVGYETRSNDGTPVMNFACLYECGSLHPYERIVFQTFSLAKIMEGIGMATKADPNHHIPESRADTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z104</accession>
    <name>A0A8B7Z104_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110982764 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097096.1">
        <property type="nucleotide sequence ID" value="XM_022241404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z104"/>
    <dbReference type="GeneID" id="110982764"/>
    <dbReference type="KEGG" id="aplc:110982764"/>
    <dbReference type="OMA" id="TELCFES"/>
    <dbReference type="OrthoDB" id="5964095at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022097096.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="44137" checksum="7AC7E769127341EF" modified="2022-01-19" version="1">MLVRLDQCIVPNAGNPHSRNRNDVILPRESSSYLVLWPPPRHSIHYLRKGIVMGTRVRHRKTALQHNCRRSRLFHRCATPIAAKIRVLGFQYPSFSTVKPLLVLKLERHVCSQLTYNKIMVEGSIRSYDPLAYHVNNVKDIRPDIVRAHRENDTEEIKRLLAEGEPSDYDVFICVNEGWHAFVLCAPANEVTPENDPLNVFQDMPIHDPFAIPNQLLVWAAELRFESAQQRMYKIRFKLSMYGEMKSKIKRCFYIGKYKRVPVSGLQLAILRASPRRYKVLLDDCVEFAKTFCYELLSFSDNGREIEKLVEEQLNKASGSGFSVEVLSRRVRSSGLVGNTFFGGLDASAFLGDVQCPRGVVCVTLVMFLTVYPIVVTLLVLYFKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3K4</accession>
    <name>A0A8B7Z3K4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 50-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110984377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100213.1">
        <property type="nucleotide sequence ID" value="XM_022244521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3K4"/>
    <dbReference type="GeneID" id="110984377"/>
    <dbReference type="KEGG" id="aplc:110984377"/>
    <dbReference type="OMA" id="RTHNAYG"/>
    <dbReference type="OrthoDB" id="5406014at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF76">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="378"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="487"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022100213.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="60313" checksum="985E6D77D22C7382" modified="2022-01-19" version="1">MAAMWRGVPELHVAIHRGQFHDARQLVSAGDDVNCRDANHRTPLILCALVEQEQWGVGIARMLLEMGALAGLVDKQGRNALIYACIYRRLELVEVLLSAVDFDLNHRDRFGNTALFYAASGGNADVVATVVKKFKHFGETLDKPNKFGMTPLLEACRLGHERVARTLVENGAKVERRDGVRHWNAVDWQQEHDRHVEATNRARNRSYNKPWLSTKNTSVGKSEPGQLRRATSLPGISGSDCHGLSDGRSSSESMDPIVPERAQSVPRHTLSRAKTMSVLPTLNSAKLVGVTRNWISDTGGKELIRAKFYPSPAPFANPQLTTDAERTHNAYGQWRMTQNLHPVNSLSSRQHNQSDSAIWQKEFRQIFKRYENQVSKSFRRKARVPPPGYRFRSHSPPQITQPSITVDGDRKAPSGRLSRRQSNLDFGPPLKRLPSVNSIDTSSVSSRKATAPSSAVKGGRRDPDSSSSSVDSAGAAKMVMNAFRRRKSTAFSSSSSIVKTSEDETESKVGNSGSDRSAATGRVRKTSITGTRGGGAIAVENGDKNITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z527</accession>
    <name>A0A8B7Z527_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17 18 19 20 21 22" type="primary">LOC110984232</name>
    </gene>
    <organism evidence="14 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099889.1">
        <property type="nucleotide sequence ID" value="XM_022244197.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099890.1">
        <property type="nucleotide sequence ID" value="XM_022244198.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099891.1">
        <property type="nucleotide sequence ID" value="XM_022244199.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099892.1">
        <property type="nucleotide sequence ID" value="XM_022244200.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099894.1">
        <property type="nucleotide sequence ID" value="XM_022244202.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099895.1">
        <property type="nucleotide sequence ID" value="XM_022244203.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099896.1">
        <property type="nucleotide sequence ID" value="XM_022244204.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099897.1">
        <property type="nucleotide sequence ID" value="XM_022244205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z527"/>
    <dbReference type="GeneID" id="110984232"/>
    <dbReference type="KEGG" id="aplc:110984232"/>
    <dbReference type="CTD" id="8453"/>
    <dbReference type="OMA" id="PRPVWND"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000012">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000016">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000018">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000022">
        <property type="entry name" value="Cullin-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="387"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022099889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022099890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022099891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022099892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022099894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022099895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022099896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022099897.1"/>
        </source>
    </evidence>
    <sequence length="744" mass="86477" checksum="A1A9A887B918C37F" modified="2022-01-19" version="1">MSLKPRAINFEQTWDRLLETVKGVIQLGNVKRKIWNDRFSDVYALCVAFPEPHSNRLYEETKIFLEEHVQALHKDAIQAGDSLLFIYHRHWQKFSRGASYLDQLYSYLNQQFIKRQKMSEADRTFGYSLDTDEEQLMDIGELALDTWKRLMIRPLKKNLHELLLREIHRDRCGEDTNQAVLHSVINSLVDVERYRQKDQVQLYQELFESKLISETGEYYRKESANLLQKHNCSQYMEKVLQRLQEEDLRSRKFLHPSSYNKIMHECQSRMVADHMVFLHGECRNMVRNELLADLSRMYKLLKSVANGLHIMVNDLQEHIKQTGLQAVSSLQGENIHALFVDAILALHSKYTKMICETLGKDKVFTMALDKACAAIVNHRPHQRQPCRSPELLAKYCDTLLKKSAKGVSESEIDDKLQQSILVFRYIDDKDVFQRFYARMLAKRLIHGLSTSMDAEESMINKLKQAFGYEFTNKLHRMFTDIGISEGLNGNFNTFCQTKQVDLGVNFSIYVLTTGSWPLGQSSLTPFAIPQELEQSVSKFEEFYSEKFPGRKLTWLHHLCTGELKLNYLKKSYIVTATTFQMAVLLLFNSQSCLRYSELLENTQLSEKELQKTIQSLLDVKLVESQSQDNLETSVTCSYILNMGYSNKRTKFKITTAVQKDTPQEVEQTHVAVDEDRKLYIQAAIVRIMKARKQLKHSILIQEVISQAKARFSPSISMIKKCIEILIDKQYLERTAASDEYAYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5M8</accession>
    <name>A0A8B7Z5M8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110984764</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100937.1">
        <property type="nucleotide sequence ID" value="XM_022245245.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100938.1">
        <property type="nucleotide sequence ID" value="XM_022245246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5M8"/>
    <dbReference type="GeneID" id="110984764"/>
    <dbReference type="KEGG" id="aplc:110984764"/>
    <dbReference type="OMA" id="KEPQHAY"/>
    <dbReference type="OrthoDB" id="5957813at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF364">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022100937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022100938.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="59975" checksum="60976FB6B3996464" modified="2022-01-19" version="1">MGSVRTTFLRLLLITAAALIMPAYFAVWKFLMVDSIPHNRLTSKGSHSTHNNAGAQFADLRRPVAKQSESSNKSSGFSPGVKLATETHQQRKRAAAKDPGSKTLQTHITIENTPSRSHIKSTENVLKGKYKNVNYWQSCKFLKTSKGLHRVCIDRYTNGSRGRLTAKAVMAQKQYFTEKPVLASGDSLNRQLISKVNSDDGKVTEHPKKRQGVKKPRGHRVPPSPSPKSPRRGILDYALWLSYIDPHDYRYLINPSSTTCQTSNRVDLLVLVTSHPENSERRKVIRETWGAPRGSTAVSAVVKVRFLLGVTALTGGQSVGVPSDLLREADKHDDLIMEEFLDSYLNLTIKTVMGLKWASRFCPDAHYVMKTDDDIIVNVPKILAFLHAAPRRALITGRLAKSYPVIRDKWEKFYMPKHIYSKSTYPDYCVGLGYIMSIDMVHKLYLQSLLTPVFPWEDVYVGIMLKDIGIIPKDIKNFYYFNGGSLFEGATILVAPKKTLYRLRSYYVFDGLTPEQTRILWKKWQGYQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z759</accession>
    <name>A0A8B7Z759_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neuralized-like protein 4 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100635.1">
        <property type="nucleotide sequence ID" value="XM_022244943.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110984602"/>
    <dbReference type="KEGG" id="aplc:110984602"/>
    <dbReference type="CTD" id="84461"/>
    <dbReference type="OMA" id="VMTHRSL"/>
    <dbReference type="OrthoDB" id="49113at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12887">
        <property type="entry name" value="SPRY_NHR_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000001">
        <property type="entry name" value="neuralized-like protein 4 isoform X1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF14">
        <property type="entry name" value="NEURALIZED-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="35"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="257"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="468"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="652"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="842"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="NHR" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100635.1"/>
        </source>
    </evidence>
    <sequence length="1469" mass="162241" checksum="DABF43E47024DB8B" modified="2022-01-19" version="1">MKPPKNFPIIDVIQNNDNFTLENGDSSLNMATTMKRRFHQRHGNLISLSSNGRTASRNEPRQEFNNGLVISKSVLKENEIFEVRIDKKVETWSGSIEVGVTSLDPGNLEFPTSATGLCEGAWILSGSTVLHDGEAILDEYACDLDSCNVGDRIGIQRTNSGELHLFHNGVDKGVAATGLPARVYAVVDLYGKCTQVTLLNTAHGVNHSSDDSSSEDDSSVSEDNVDDEDTETEDIDRVEELRVPLDNASISLPSNNALLFHQRHGSLITLLNNGRTAERGNAREEFNNGVVMTNRLLRSNELFEIRIDKLIDKWSGSIEIGVTTHIPESLDFPSTMTNLRTGTIMMSGCGILTNGKGTTREYGEFDLDDLAEGDRIGVMRKANGDLHFFINGHDQGRAVSNAPQDIFGVVDLYGMAVRVTILEWVPPATHAMTSFVDQRVSQLSYLQSLAQQESPNVFQAGSWEWTDRPRFHETCGIHAQVINGGLTAHRPNAMDDFNNAVVLTSRPLQNDEMFEIRIDRIVDKWAGSIEIGLTKHSPEELDFPSTMTNVRSGTWMMTGDGIMHNGVAIVDEYGLNLDRLREGDRIGVMRKLNGDLHFFIKGVDQGIAATNVPPNLFAVVDLYGQATQATIVEPGDYAEEPVEAQVPADDNILRFYHLHGRNVKISNNGLRAQRPSATGEFNDAIIMSNRPLRVGEMFEITIEKMVDRWSGSIEAGVTTIAPEELDFPSTMTDLDHDTWMLSGACVMKDGLMLNNSYGLDLDTVHEGDRIGIRSWEETLHFFLNGRDMGTACTNVPSDVYAVIDLYGQCAQVSLVPSSTPNNVLVTSRQDSHNSVITVPGLMHKFHTVCGSSIQLTEDFASACRIRTFDNAIVFSDKALRTDELFEVKVDKVASQWSGTLLIGLTTLNPDDITDGQVALPITAASLRSKDTWVIQGSQVKHNGKIIKDNFSSTLERLGVGDTVGVKRCPDGTMHVFLNGDDLGTAARDIPKSTHAVVDVYGVVEAVSVTSSSTTSLESQRAPSISSSSGEDSDREQGEPTCSNPNRIHFHKHGKNICLSDSNLRARRTASYNQAVVISEYPLPRKKLFEIKLEKVTDEWTSSVKIGVTNQSPERLGFPASASNIKKGTWIVQGDAVFHNSNKVRTFNGPNLDQLKEGDTLGVLVDAQGQLHLYVYGRDHGVIAEHIPNPCYPLVDLYGQCKEVSIVTEELGAIGVQEEREKAAFENAGLKENTPQSLYALGGSGRICEYQKLCLRFKITLGLHDAHFETNPKFNKCYCEPCRKYQGTSEYGDQGDPLQRYTRPFGWCKFAIKLHSRAETLNVFDLWHVAFHGTKAGAVRKILDSGTLLLPGDIALGGDQLTEQPGHFNDSHKPKDFDTKQIFISPSMNYAGCNVYAKKQKFTDPKTKQVYNASVAFQVRVRPNSYTTGPQTIGVNHNIDPYIENSKIEWFTKERSAIVPYALLVRVQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9K8</accession>
    <name>A0A8B7Z9K8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C7orf72-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102353.1">
        <property type="nucleotide sequence ID" value="XM_022246661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9K8"/>
    <dbReference type="GeneID" id="110985560"/>
    <dbReference type="KEGG" id="aplc:110985560"/>
    <dbReference type="OMA" id="RDGHHIR"/>
    <dbReference type="OrthoDB" id="5983862at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027867">
        <property type="entry name" value="SPATA48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34759">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34759:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15073">
        <property type="entry name" value="SPATA48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102353.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="50908" checksum="84DAED6ED069D68A" modified="2022-01-19" version="1">MVDTAVRPRPVGDLRLHMQTDTNAGPNSIQQVVLNRRQRQMKFPHLRGRWDVDSFQWKSSPNLVKYHDDTLAPLRDNVPIIDPVSGFVSAATDVDRNTGVDRMPSMQQVDNTPNTVTPLSPRPTTTKAHREKEKEKDRGTFVPKKPVTPQFSRARSNPEMRLVKSESDVTHILNDPGTWAGRKISDGFIRAKLGGWTSSVDPRDAAKEQERIWRQIHARNIKGQMDAVDKSPNWRDEAALRYIYTSAAQRTSEDVDWDSKLPPKILPPASTMEAQADPVSQCFTNMKRYDPKAQPWQNLGRSWDWFQTRDGHHIRGPIEFCSPHRKNNQIPNYTGSIGGEGERDDPHKFFIPTTVLRSLVPKYTDTARRANIPGYTGCTHWIGTESANLNVGIPQPQTTARVHRSLPADLNMSPHKRTSRMSRMITLVPPGNPFNAISKEERTLEQYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAJ2</accession>
    <name>A0A8B7ZAJ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peripheral-type benzodiazepine receptor-associated protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110985335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIMBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101987.1">
        <property type="nucleotide sequence ID" value="XM_022246295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985335"/>
    <dbReference type="KEGG" id="aplc:110985335"/>
    <dbReference type="OrthoDB" id="4158657at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12014">
        <property type="entry name" value="SH3_RIM-BP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12012">
        <property type="entry name" value="SH3_RIM-BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12013">
        <property type="entry name" value="SH3_RIM-BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000023">
        <property type="entry name" value="RIMS-binding protein 2 isoform F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000006">
        <property type="entry name" value="RIMS-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000072">
        <property type="entry name" value="RIMS-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000016">
        <property type="entry name" value="RIMS-binding protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057884">
        <property type="entry name" value="FN3_RIM-BP1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035753">
        <property type="entry name" value="RIM-BP_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035755">
        <property type="entry name" value="RIM-BP_SH3_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057950">
        <property type="entry name" value="RIMB1/RIM3A-C-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040325">
        <property type="entry name" value="RIMBP1/2/3"/>
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    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234">
        <property type="entry name" value="RIM BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14234:SF19">
        <property type="entry name" value="RIM-BINDING PROTEIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF25523">
        <property type="entry name" value="Ig_RIMBP2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25566">
        <property type="entry name" value="RIMB1_N"/>
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    </dbReference>
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        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
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    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="1397"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="1629"/>
            <end position="1718"/>
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    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="1721"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="2275"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="2398"/>
            <end position="2465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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        </source>
    </evidence>
    <sequence length="2587" mass="281746" checksum="530FC3268C92E8EE" modified="2022-01-19" version="1">MSSGDGPVMGKPPIGTPGSRNKTPSTTPRSSGSTPRQTSASAGRTSNGRPAVPGQVTKSARPNSVTKDTEATLRRKIERLKSELDSRTSKPTSKPGHLKSAGDTKSVSANRASSTALVRSTRNSKNSLSKSLSFEGPASGSKDSTKVQTPPNSQPKASTARRSGGGLPEARLAKTLPGSITDSIGDGKGGKPAPAPVPRGLPRSNSKPDLKKGTSSISDPPKSSSSVSELPDSPASSQGTSLKRTNTYLVKKGQPSASTRVPVIHALPKAENAKTAVVENTSPWLRRNEGDTVCTSEDPKGEPPPCLNKGSNDRRIPKAAASISESSSVSDGIEVYGKMNPDYEHREKTVSNDKVDVTDQPEDLSSIGEGPAPEIKEGSDILQTEAHIKRETGFNVEAGRTLQEEEEPLQHAERKEEDNFMAELKKSPNSQVDDQQTQVETTRSKGGKEELEHLVARQQQEITTLRKENEHLLDPDEQFALSLAPCVAGASATACVTPRGIAPPLSLPESPDAPDSAQLQLGAGGRAPMFVAGSISHLTTVGEDQDIADTPPPASPPDTADFHMSVLGSNTGNKEPPAPAFVEGSITACEILIDDECSIGNVQNTTVAYDSRKFASQPPQVTFNVPIETVINPGETIPSLAHDSVMVSAPRLEPIDFQTDVDDTTFKPLNSDMSNLGVNMPPPLSFQDSGEVAVSPQFDELVENAQLPLSIAFEGSAVEFCTPSDAPLKSASSSDLNGGGPELCKYPVENLAADELDLSKVLLTGQSEIAPLSAPVLGTVSLTVSDQSECESEHSTAQQEEMPSHRGNLKRAPTSALGSAAQSVIGSGTGTGDGMDERSRLHGGPALSRDAPREHRTRQQVEELQMERKPTEERIDKLKKRNIELSVMAKRLEEKAKQIQKQKKGDTSPTPSNGSPSPLQQTSPTAKPTEAADFYKRLLAKQRAHYLAENAQKLLAKDKEIRGLRQELDRQRPGVSPEPGLEQNSLINAEKMHLEQIIKGNAKEQLRLQRQIQLASSAPDAQTNGLGNIRYQTIEDANRALRIKCAKLEKFREENTLSEVEVTQQRLACENLEKALSEERRKCTDVSTDYQNALIQNTALARKNAELQEKINLLEHVNRECQKLRVEVNEQRQLFENTALERDILHEKVEKLERDLSLMQDAEEKRRALEQEYEQAIRELREKQEEIRRLQQEQQVAKRDHHDSVSRLAAKVKDLERKCDEQSSNFSRLSNELLALRNEAGSQLFTMTGAGAATAGPADSTAQPVVGGVGVAPSRKGTGDKEDWRKIAEEAVVTRASATSVQASQRLPSEQRIRSNLSKGGLPGRDESEPTLEKRTSYPASGDTVSRKSDHSRGIENGQLDTSDAEDLMEDLSDRIDAAILNRLNQASSITTMGPISKLAVFIARYNYDPYRDSPNDNPDAELPLTAGDYIYVYGDPDEESEWDGFYDGELMNGQRGLVPSNFIERVAGTRDLNDIREEDIPGFMNNNGMDSDASKLDSTGSSVKYSLEGALSAPPKPSHEALLSDPPLAVAGSSSAAAVGGVGAPDLDDMKDLDFNSEEEDLNRGNLNHFAGELQSFSRSSEHHSDLEDIPEVDEDNGVKGQSRALASEEGLTSLSDIAADYVFDVPCPKKLTLERQLKNSIIISWLLPDTIAPADVQEYCVYVNGQFRTATKWDAKTRALVENIKPLETYRISVRTVTSKGTSEDAACTIMIGKDAWAAPTDLKASNVSPTSADISWLPGNSNLAHQITVNGKEVQTVKPSVYRYTLTGLSPLSVYRISVKAKSRKTSQDVKEKLATEIEFKTLPGEPKRSKKKKRSLPCLPDAPLDVQVKAGASPAICVVEWLPVTITTSGLSNGAVVTGYAVYAEDTKVAEIHSPTADKVSVSLNKLKLLAARDVVVRTLSPNGFSIDSVPARIPPVLLEERRGEATLRAMEAKLSPRRNSHGGHRLTNYRRKSRRRYSHPSTMYHGAEEEDSSTHSSRSEDLHHAHDSGTTLTNTKPPAAASSGKAVENATGKEDLVKKADARVPREDYTSESERSELSDIAEEAEEELSDFADGSLPGLSDESEAKALKKMKRREDEQKKVQETLKYNAKPDIELDTDPELESLNKSDKCRPIQVIRQQCDFDREAEQSPHNQVLEPVPIKQTSQPGQAVPHIEITQDEARKAAASEKRSEPTGQPSLPQQPLAAPDPKSRPSTEQPPRPSSPRKSSLGEDLQPAGLMKPSTYKDYDAKSNNDRQRKLSMDSRTDETGTYEDEEDYSVSEGPEELFDDSVIRFFVALYDYDPTAMSPNVDAVDEELTFKEGDIIKVFGDKDADGFYMGELNSQRGYVPYNMVEEVEGPEQTPLNPPKRASTATSGDSPDRVGYTSSLNTTTSSPAVQLLHSPINSFRIPPDARPQKMRALFDYNPQELSPNPDAEAELYFHQGDIIVVFGEMDNDGFYLGELHGQRGLVPSNFLEAIGDTPRPESVPSPQPYSTPTHQPYSPSHQAYSPSPSRESRGSRGSRGSYSSVRSDDRQTQLQHTRHQENGEAPVKGREVRSNSDVADQSGDSMGTPEHIKKKKGLLSKGKALFKKLGGDSKQKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAV3</accession>
    <name>A0A8B7ZAV3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110985314</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101945.1">
        <property type="nucleotide sequence ID" value="XM_022246253.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985314"/>
    <dbReference type="KEGG" id="aplc:110985314"/>
    <dbReference type="OMA" id="PILYMEL"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF303">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER INE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022101945.1"/>
        </source>
    </evidence>
    <sequence length="635" mass="71074" checksum="A80268781AC7BDFD" modified="2022-01-19" version="1">MEQRGASNGGFNYEFDGGEKGGPEENNSDVKFSALEVDDRGGYSKGNEADVMDLEKSASAAGRDRWGRKAEFVLACIGYAVGLGNVWRFPYLCFKSGGGAFLIPYFIMLILCGIPLLVLEFGLGQYVRAGPVQAFGKICPIFKGTGLATVMISFVLTTYYNVIIAWALFYLVASMQSELPWDSCNNTWNTPDCFSHEDYKMLNGSTKPNNTVSSTEEYFNHRVLQITDSIGNAGEMRWELLGLLFLAWVVVYLCLFKGLKTSGKVVYFTATFPYLVLLVLFINGLLLEGSAKGIKYLFIPKWKELLNVNVWVAAAAQNFNSIGIAFGSMIAFSSYNDFHSKTILRDTFCITITNSLTSLFAAVTIFSGIGFISHIQNQDVDTVIQQGPGLVFVVYPAIFSTMPISQLWSVLFFIMLFCLGIDSQFAMVKVVIATFMDGLPKLRRFYFNRREVLVLYICIVSFLLGIPHVTQXGMYVFQILDWYNAIVSLFFIAIFEVTSVAWFYGAKRLARNIKEMTGSPPNIIFVICWVFLSPALILVIMVFQFIDYKPVKYGGQEFPDWAIAIGWLVAFTSFSCIPLGAVHTLLTTKGNLKERLLLSFRSPIDEATYSLQFSEPKFDKDVPPSYEVAVQCEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB16</accession>
    <name>A0A8B7ZB16_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Inner centromere protein A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110985342</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102002.1">
        <property type="nucleotide sequence ID" value="XM_022246310.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102010.1">
        <property type="nucleotide sequence ID" value="XM_022246318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZB16"/>
    <dbReference type="GeneID" id="110985342"/>
    <dbReference type="KEGG" id="aplc:110985342"/>
    <dbReference type="CTD" id="3619"/>
    <dbReference type="OMA" id="TKTRAMI"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990385">
        <property type="term" value="C:meiotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051257">
        <property type="term" value="P:meiotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051310">
        <property type="term" value="P:metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1084"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="749"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="762"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="888"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="489"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="500"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="697"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="762"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="775"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1081"/>
            <end position="1095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022102002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022102010.1"/>
        </source>
    </evidence>
    <sequence length="1164" mass="133962" checksum="61738E7C34C9DA3F" modified="2022-01-19" version="1">MLSSALTTMRMGELPGFSLHLITTAKIKSFDEMFEENVTWLQEVLEDAKKQFGREEMAMFPKTPVLRRRRQRIRRVSTIHNEDIDCQLPKKNKRSSRASILGKACQSRQSTVPLRRSARNSARSTITAQNGTSRTRTSKKVQIHENTVEPVQGLNSSDTSSCSDDVDTTKKAALKDEPKRSSDSSVITTTEAPMDTEECGNQATRAYDTVAIKSDDPSIGKNIKRNAVSKTKKGSKKLRLNSGEAVSTVSDSSISDEYETKSKAQLQMVKENSSSIALKGTEQKEETLTRPGSTATSKTERPKRKNAASRYKDHVKRLISHHEHLIAEQVTSSDDEFQSPKHKQVVREAVQKAKQPVPAKKNKRKNVKEEVNQDAPEKPECISEEKSDDEVFDNENAVNNSKSKKEESPEKMQEQPSSLPSPIVPEQESIPETVKSDEGTAVKDVDSVESIKLRFSESEDENQQQDSQDEHTDDVRMEGDEQSVAEDSLDQRSIAEDSLNKVNTPDNSPKQLQEASPKPADMTTDSLDQQNMTEDSLNHNDMSCDSLNQSTSKARMTRQSLRKNLSLSTRRSSVAVSCSKKRSSVYRHRTSIRKSLHHSVRNPCSTRASTRASTRRATVEQVLQESIETSSQDVMEEVLPEEDAPVSPNDKEATPPKRMSTHPPTINQETQRITRAASRIAENQKSSLEKQDEVSDSPKSMDSTPDNQSHDNSCSSDDFVSKTPSPKCPANKVVRPRATFLSSGKKEPRYLNNLHGMVSSFIKRNTPQKQTATERQQEIKKNILNKQRRDEEIRRKLEAEKQKQRELQKRKREERIKKVTEARERRAAIQEQKRQEMEQKQLQMSRQTTKKIEDKKQEEILRKQLQIKKKAEAEERRRQEERVRMMKIKEQEEEQRQHQEMIQRKKEFEEQERQRRIDEARRQQEQRRGEMERQRLEELQRRRDAELAKEREMELLKEERERERKAEMERKREQERWAREEALEKERRIEAERLAREKERQQDQKHLAEIMQQERERRELERQKEQAEHDRLKASILKHNTSACLNTSSCLNTTVTKDTSPTSYDMTPRRVPLPSTSDNYNIDDLESGDSTDEEDSPRKTIPSWAQGAGLKAALIKQFYHPPPNLDTMFGPLLPPDLSIIFAKKRSRYLKRTSSAVWDSPLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEK1</accession>
    <name>A0A8B7ZEK1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Peroxisomal N(1)-acetyl-spermine/spermidine oxidase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC110986019</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103284.1">
        <property type="nucleotide sequence ID" value="XM_022247592.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103285.1">
        <property type="nucleotide sequence ID" value="XM_022247593.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103286.1">
        <property type="nucleotide sequence ID" value="XM_022247594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEK1"/>
    <dbReference type="GeneID" id="110986019"/>
    <dbReference type="KEGG" id="aplc:110986019"/>
    <dbReference type="OMA" id="ASQIGYY"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046592">
        <property type="term" value="F:polyamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF377">
        <property type="entry name" value="SPERMINE OXIDASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665707" evidence="2">
        <location>
            <begin position="24"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="231"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022103284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022103285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103286.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="60696" checksum="DBF43B9B173F77BD" modified="2022-01-19" version="1">MATKRCRPSVVVVGAGMAGLAAAVELTEAGMFDVVVFEALERPGGRIHTFVMDKEKHSGPRQIELGANWIHGEEGNPVYHFARENGLLKEEDSSNGESSSDDSSSTCAESNDKRTWINTNSDGDIYFLEDGSVASRSIVKQVRMMYDNLITACRDESTHDGCVSVGEYFVRGMEQLISKGDVSADERHVRELLWKWCLRAECIDCACQSAYDLSLIHYNSYIDIPGDYYCCLGEKGYQGVLDVLLGRLPKDTVKFNKPVDQIVWKQKSPTDEASCGREPVIIRVKDHPDIVADHVIITSSIGYLKENHARLFRPALPEDKQKAIDTLHFGTVNKVFLKFEEPFWTRLSEGDVEGIQFLWEKDPWHDEPLVTVQTSDSSKENLKDLHDQIMRRFTGFDTVDGHDDVLCGWISGAEAVEMEKFTDADIAKMCTDILNKFLPTEIPAPTKVMVSRWHENPYIRGSYTSTLPMHGTGEEFDVLSSPVWQGSQAGDAGMAQYPVLLFAGEGCHKEYNSTVHAAMITGQQQAQRLIQFHQLSTKPSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFD8</accession>
    <name>A0A8B7ZFD8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Matrix metalloproteinase-24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110986273</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="12">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103712.1">
        <property type="nucleotide sequence ID" value="XM_022248020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFD8"/>
    <dbReference type="GeneID" id="110986273"/>
    <dbReference type="KEGG" id="aplc:110986273"/>
    <dbReference type="OMA" id="CPKDSCN"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000068">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000005">
        <property type="entry name" value="Stromelysin-3 preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF294">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034459136" evidence="16">
        <location>
            <begin position="25"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="17">
        <location>
            <begin position="121"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="366"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="413"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="462"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="14">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="13">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022103712.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="61698" checksum="E929F6512FB2FE7B" modified="2022-01-19" version="1">MSRGINENLWRAVWVVFCAALVTSFPTISDDPEVAEATFRYLTSYGYMNPPASEEGDIATITDVESAIRRVQYFANLPETGTVDAATLEVMKGPRCGVPDPVGRSVNGTVLGGRLRRYAHTGGKWNKRDLTYRILNSPPELSYSQVVETIREAFKLWSDITPLSFYEVTGANYADIYLRFAPYNHGDQFPFDGPGGTLAHAYPPLSGFGDLDGDVHFDDSETFTIGTYDGVNLLQVAAHEIGHSLGLSHSSVQGALMQPFFPGYDPNFKLHYDDILGIQTIYGSGGPQPGPNPDPTYRPVPDPTEVPVTVPKPDRDTCNKAFTTMTLIRGEIFGFRGARYWRIAREGQLISSPEGDKNKYFWVGLPPRIDAGYERWHDQKTLFFKGNQHWLFDGITLQDGYPRLISDLSRDLPVDIDAAMTWKEYSKTYFFKGDMVWRFDEATQTVDPNWPYRIKDIFPGVPSNLGSAFRGRDGNGYFIRGRKYWRYNDTARAVDPGFPRYFGSDFLNCNLEAIMEDEAREAAEQPNGAVGMKGVTGALTVVGLAVAWLMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJI1</accession>
    <name>A0A8B7ZJI1_ACAPL</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110986980 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105040.1">
        <property type="nucleotide sequence ID" value="XM_022249348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJI1"/>
    <dbReference type="GeneID" id="110986980"/>
    <dbReference type="KEGG" id="aplc:110986980"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="389"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="665"/>
        </location>
    </feature>
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        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022105040.1"/>
        </source>
    </evidence>
    <sequence length="756" mass="86173" checksum="4595ADEA0C3F6BD6" modified="2022-01-19" version="1">MMENTCTSSMSAYYQQMTSWICRHVRPNQSGISRTAVQVLSTTSCIPSDIHCPSSTRLSKTWARRRSYPKPEYYPDKLVDGICGNSNARSKHREADENDQPICCLYLPGLPFSRWRRRRQAKVAPFIPLSPPIKPTVTSPTAGHEAPAQPKATELSVFDLEDENDQESPSLGLPSRQMIKQDFDEWRRRERRVTHIGLEQDEIQGISREVIAFPPRPKTSRGLRSESERKDRPSAVKTLELSGHEVNMWIRECAEVLNPQTLGSKTINEPGSSNDNLDEEKRVSVKSRGVCDTFEQKELVVTGHKQILANNDTQREYAGRSTKTSKVEPLPPRPKTSRGTRRENGGGDSLSVSSAVRVVEAGLEQAVRDVLVLDTAESLELTNEKRHFSLKDSRGSGKVLNPGENLDEVDDDERNPTHASGRVDEHNTKAAKGDEMAPTLDQVSPPNCAKQNQPITPKSSKNSMDADDMMITAEQEMEYERQQHEQWQLAAIGEWSTLCQDHDEDDYESECYLRMDEFQKETAIMMDWKAIVEQYRTVGVIQDLQNIETLCKSTINQSERALRQFARICRGPVPLSKSGQTKAEAIASLSRIVQKQTRRICEDISNVFSESYQILEELDLLRERQDRVEESLQRDLREKDAEEERSRSSSLSSTATPRLTSSRLQQREIDQDLVDRYMEYPRVKSTSLFNVMPTIYEDKIFQLNEYEEEEEELESDLPECKGMEDVYLHEDDAREHDTAEDDCPDVLLVEELGVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKW2</accession>
    <name>A0A8B7ZKW2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rab9 effector protein with kelch motifs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Rab9 effector required for endosome to trans-Golgi network (TGN) transport.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105530.1">
        <property type="nucleotide sequence ID" value="XM_022249838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKW2"/>
    <dbReference type="GeneID" id="110987259"/>
    <dbReference type="KEGG" id="aplc:110987259"/>
    <dbReference type="OMA" id="ERQPMKE"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052124">
        <property type="entry name" value="Rab9_kelch_effector"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46647:SF1">
        <property type="entry name" value="RAB9 EFFECTOR PROTEIN WITH KELCH MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105530.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="44274" checksum="7E1B241A8E3F2601" modified="2022-01-19" version="1">MALTLVSLKWIAGKEFTGRPPSPRQGHAIAVLDNAAYIFGGIRCVEEPEKGIFYFRDLHKLHFGKILRWEKIRYTGDAPMGRHDHALCAIETTLYVFGGRNEMNADECLPGLHAFSTKSCNWKHIQTHGVEPRSLNPGWAVVDKRIFVIGGIYKGEAHCNVDVLDTETSTWTRLSVTGLPPAPRCDHRLMPVGRSIYLFGGCGGQNKCFNDLHALDTDSLQWSSPPVRGDPPPPRGCHSLTLHADKDIYVFGGSNDGLKGKTTLGDLHKLSLAKMKWKRPFYSGNPPCRRFGHVACTYLNHLYIFGGTNEDMDYNDVKAAKLINPSSRKPLKVSPELLHDVLYGRADQNNEGTSAAMLPLHESVLSSATDQEQGDSDDSDASDTASSSSSSSDSDASDSSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKW6</accession>
    <name>A0A8B7ZKW6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dyslexia-associated protein KIAA0319-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106268.1">
        <property type="nucleotide sequence ID" value="XM_022250576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKW6"/>
    <dbReference type="GeneID" id="110987659"/>
    <dbReference type="KEGG" id="aplc:110987659"/>
    <dbReference type="OMA" id="CICESFW"/>
    <dbReference type="OrthoDB" id="536372at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000061">
        <property type="entry name" value="Dyslexia-associated protein KIAA0319 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000258">
        <property type="entry name" value="Dyslexia-associated protein KIAA0319 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000257">
        <property type="entry name" value="Dyslexia-associated protein KIAA0319-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029865">
        <property type="entry name" value="KIAA0319-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056502">
        <property type="entry name" value="KIAA0319-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013980">
        <property type="entry name" value="MANSC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46182:SF2">
        <property type="entry name" value="FI19480P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22352">
        <property type="entry name" value="K319L-like_PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23620">
        <property type="entry name" value="KIAA0319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23597">
        <property type="entry name" value="KIAA0319_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1071"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="PKD/Chitinase" evidence="10">
        <location>
            <begin position="497"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="PKD/Chitinase" evidence="10">
        <location>
            <begin position="597"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="PKD/Chitinase" evidence="10">
        <location>
            <begin position="696"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="PKD/Chitinase" evidence="10">
        <location>
            <begin position="785"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="777"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1130"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1166"/>
            <end position="1176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022106268.1"/>
        </source>
    </evidence>
    <sequence length="1215" mass="133463" checksum="F6C19F8DEBA44DC3" modified="2022-01-19" version="1">MGPVETTQDPGLCPCCTQSRTKLSQNPYHERNSVMLTLSLISSSLDQAPWQLRSIKVALNIHSQLFLPFTLLMMLLLQTGLADATCSTGEPFVGYFPSVSEKQLKLQHGTLASDCAETCCLEEVCDLAWIMDEDCFHGQCYTESDCIPLASMSASSIVYVMERPTQPRTPVSGVVCSPHDKWDTCPIGEHCDKRLGECQCNDGRTRSYKTNRCEYEQRVEPWNSLTGSDSLKKPEYAKTYDSHNPYADKSEGFLDDVSKSGTSEEDDKFRFCKSEEECEEYEYCFGLQHFGAGICKCLDGFHESKELGMCIRETPEGEVRESPKPVTMPSKPSSIADSENPLTTPPATPPVTLPETPLATPPEDGDTPKETHVPTLVLLPTPQVRNDTDKQGGSDGGGANGAGVGGSELGDREERPHKKSEGKGLTHQGDTAETQNGTESNPSDGDNIAPTPLSDTPTERAGTQSNTGLDQLTDRTLLPESKTQSPSTHTPTVVKLTVSAGKDKTLQLPDQDTVTLHAYVIPTEPPQGQEYTYDWQVVDEPDSGAGKMIKEGKNLKLEELSAGVYQFKVEVHGKGSYGSATINVTVLAPPRVNQPPKAIINPVSQEIILPNPGTYLDGSHSTDDDKIVTYHWQEIEGPVKETKIIGDDQLLQLTDLVPGHYVIRLTVTDSDGVTDSALANVTVKEEIDNPPIAKAGKDVIIKLPVNSAVLYGNSSFDDHPGLVYEWSKISGPVADMSGSSSPILHLNSLEEGTYIFRLTVTDSKHRKDSDEATVIVKPENNLPPRADAGPDKELSLPDDSTTLDGIGSTDDLGITSYFWEKVSGPNDPKIEDADHAMAKVSGLIAGRYVFKLTVGDRQGATNSDTVDVVVKKEVNKPPVARAGPNITIHLPNSGVELNGSRSKDDKGIVSYEWKRDAKSPAAGTRYSHRLNLVVLTFDVEVSKFTYQNRIDMARSLAVLLSVRDEDVVIQQVYQTPNEQLQVMFYANNATTSTAMPGPRVVKILSKKKLSGEMDLLKFKVLELDTMICQKNCSGHGKCDPFTKMCICESFWMENYVRRWMGDRESNCDWSILYVIIAACGEAIALVGLCWLCIYCIKRSRRKVKRRRRYNLLSQDLDGMESMEMLPKNANEPQSEMTNNGNGSVLDKLTDKGSFQGKQSSSIMISESDDDTDEETTLFDSKKRQGKNGKANGSVMAVQPRKKRPFPLISSRSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKY2</accession>
    <name>A0A8B7ZKY2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine incorporator 5-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110987667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106283.1">
        <property type="nucleotide sequence ID" value="XM_022250591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKY2"/>
    <dbReference type="GeneID" id="110987667"/>
    <dbReference type="KEGG" id="aplc:110987667"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022106283.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="56968" checksum="56748B11B2FFCE7B" modified="2022-01-19" version="1">MADCCDAQVIMINCCFKGSSCACVCAPVRESTSTRILYAVFFVIGFVLSCAFVSETVAQELPKYPKLIEFCRTIGAGEGCMRLTGYASVYRVCFSMAVFFFAMLGITVGIRTSKSWRAAIHNGCWFYKVPVMVGLVVGSFFLPISDIMLSVGLYIGFAGAAVFIFMQLWMLLDFAHTWNKKWSMKIDNNGSVLWYVALVFFIVLFYAVSVGMLVFLLHYFAAGAECVRNILFSCLSFVLCIFVSVFSIMPCLPKSHPRGGLLQASIVSAYIMYLTWSALLVEPPVEVKSLLVDNGTHSVYNTTYVTCGLGSGFASTFIMNSMYTELVNAMVAAILLLGMVLYACVRSAGTALNFTGSSVNGRSQRAAAPRPKASSSMCWCCSSSTSHKEEGSSHPQNKSWGLIHNERDGVIYSYSFFHLTLALASLYVMMTLTNWYRPEEASLESLHRTWPPFWVKLGSSWLCGILYVIKIVTIMRCCENNAQSRDSVVYRQAPRGRGSPRHAGANQNRRSTTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMY4</accession>
    <name>A0A8B7ZMY4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC110987727</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110987727</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106422.1">
        <property type="nucleotide sequence ID" value="XM_022250730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMY4"/>
    <dbReference type="GeneID" id="110987727"/>
    <dbReference type="KEGG" id="aplc:110987727"/>
    <dbReference type="OrthoDB" id="5359219at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034943383" evidence="13">
        <location>
            <begin position="19"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="62"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="287"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="480"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022106422.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="73164" checksum="AA51BDC5748FCDE8" modified="2022-01-19" version="1">MDLLLALLMLLCIGGVLGDSVAVDQPKQSKIRRNRTDLEYIEQVVTLNRSRPRRDGGESVKDSLYVSEEHVYIQTRQTHQIPCLSWAGEEVLFTFWFRGEQELARQIPTYVGDSYSLNDRYQLSETHSLIIKNVERSDEGVYECRVVLSKTGVQHEGSVAVTVLDSHFPATDVANKTNLVIERGQSHEIRCPLLLSRPVSSYNIYWSLDIEETNDTSVIGARYSNGDIVVMTDYSGNYIVRDDGTLSINPLKASNSRFWCHLFLKGSGILSECIDVIGKVTSKEHFPAISNCTSDEDCTLNVENEYLRLNCSVENIYPELELSWSLGDCQESNRPIISTKAYSLYNKTSETYSQQEELQMHLPANASIKCTFICNASGLAINNPPVTGKVVVVSDRRFGSDGKDILLAIIPAICVTFVILVIVICVVLVKHRSGAKCRICPEKGIICSCVKGKGMDSNQGKGIDEEVTLLTVKSYNKDNYPRVQNQTEGQANTSAIPDRPVYSYNHTSSAGEGPSSNESGRHVYTREQHKHYTMYNYILKIVSPRKKSHPKKKTAGSHQEQVREIKAASIPLPDDNSDEDECEAGRLLEMQQLSPPACSSAGDEPCVNKKMQREESHTAEYNLLLHENNETNQEIVDKAKSPSKSTMNWRNKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNG6</accession>
    <name>A0A8B7ZNG6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphate carrier protein, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110986916</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104926.1">
        <property type="nucleotide sequence ID" value="XM_022249234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNG6"/>
    <dbReference type="GeneID" id="110986916"/>
    <dbReference type="KEGG" id="aplc:110986916"/>
    <dbReference type="CTD" id="5250"/>
    <dbReference type="OMA" id="YKGAIWL"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000005">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="78"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="175"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="276"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022104926.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42143" checksum="0EE424D2A0C7F521" modified="2022-01-19" version="1">MFFGNPRDRNRIKMFSALFDTVKRNHFSSPFITTARCEGDGAPTLPSENLSQNLPTTITTPKLASVDEETSCEFGTAKYYAICGFGGILSCGITHTAVVPLDLVKCRIQVDPVKYVGIFNGFKVTVREEGVRALAKGWAPTAIGYSMQGLCKFGFYEVFKALYSKLLGEEKTYLYRTSLYLAASASAEFFADIALAPMEAVKVRVQTQPGFASTLREGVPKLWAMEGIRGFYKGLPPLWLRQIPYTMMKFACFERTVEFLYKYVVPKPRSECSKPEQLVITFLAGYIAGVFCAVVSHPADTVVSKLNQDKGSTPLDAARKLGMAGLWKGLFPRIIMIGTLTALQWFIYDSVKVYFKLPRPPPPEMPESLKRKLAAKEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPQ4</accession>
    <name>A0A8B7ZPQ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC110987173 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110987173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105396.1">
        <property type="nucleotide sequence ID" value="XM_022249704.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105484.1">
        <property type="nucleotide sequence ID" value="XM_022249792.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987173"/>
    <dbReference type="KEGG" id="aplc:110987173"/>
    <dbReference type="OrthoDB" id="6156915at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="887"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="978"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1220"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="580"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="703"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="915"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1301"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1466"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022105396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105484.1"/>
        </source>
    </evidence>
    <sequence length="1515" mass="168053" checksum="C37DAAE4063CDAAC" modified="2022-01-19" version="1">MAFSSVLQMYLGWANSLLCEQGILIDGLHQLRSGTIFCNLIELLTGSKLLPADQDALSETDDSVALDNVQVALDFLTGIGVKMAVSAEGVVCGELKSILDVMWSIILHCTVHSPERAAYQRTVRIGRKLLLQWCGEELAVSIDTSQSMAAVFSGNNLLSDLLSLHCSFENIQDARDKYLVNLTNGILAAEDHFGISKTLLGPADVVNGTADEHSLMIYISLLKRKVSLLVSSSLSSDEDEFIKISPHKPIARALTQTRTFRFTRKKLLPRKQRMGSTKKRNRIDRVASCPFCVEPWTRVSQGVVLESPSTSVLSAANSVYSGRSSLTNLSHHSTPQPPHHRYSLDYSTFSNRTPSFDTSLTRGTNQDVTPEKSDSGISMTADPPASLPSGPSSRLKELRDHTPDSQKMAGAAYGATLDRTDQSKQIRGISRITAATSLRRHRAMYVERQHEHLASHERDSQVREKVGSVHRSASSGLLFQNASRCEEQRKEDVISKGSRQAVTEESSGSNNETKMKEGPNDGSRNPLKRGDELVQTPDDELLNLLDTIGEESQHLRLELTETQLREAILKTQLEEGLVGSTKEERVISKLVQELEMLREENRRLFRESANAKNGNAVDRKTMEKLNATIRKLQMEVEHQSSENFNLRMKSKVGSDLSSLDTRPESDIFSLESGAKEKVDKVSQSDYSSELKETPELCDLKRDLARAESQKEFLQARLKEMEEKMVQKLDQTTDDLKVSRLENLRLEKECKLLRMSSETSRLEVETVVGRCRRLEEYLSQAQKRNARLTQQLEEDALEVSSQGRYNQSLASVAKLKEENALMREKVELAEEERELLKKELAHYRQNKTTLDEVLRAWDIQTSSKFQSFLDDFRLRISEQREHQEAKIAKDLARKGQSVENNGKEFVRTETQVGNDVSRSSRSVSSVENSEQGSEGQETLSSVSRESSRDSDLQETKLLTEENLAAVANRQAAVDDKYLQFSPRRSDTETEVDSEMDSQATENAFSDLPNEHMVAAGGITKTKLSDGIRRPSLGDLIVAKAQNSPDDNDTRGQGTESYHSESMSVDPNNEKAGSVSEGEGKNSGATSTGREASRGMTTDLPRSHLSSKTRFSAVNSSLESLKGITKKAKLNPARETTQNGDSEVTVLQPKRRDEDRLTVPLKSQDDKDTVLKAGGDNVKDLEYAHTHSKIANEPTNSDPQNLPEIQPSFTIHERVGPVRGRFSRWRRMQNRPQPDFDGSYLDGSRLRSDLPKGSLEPKLDMRNRSSSLGSLLNSSSGWKESSKQSVQFEGSETATNSFESEEEFARLPERRNIAQGGTIGKGRVDAGSEKPPELGKGNCMDETKILANGHRAEGDGSDAKPQFASPQRLGNMRSKFGIKLEKELLGSSRSFSNSLANEPVAASSIKGTADLKLANGNRPSEILPTSQVASIKPGTMHSSAGDGDEQSNSSDIMTNANEGNTETENDKSVSASNSTSPDVSKMSPASYNRYYKHKMMAEKDQEYANSIIDKYLNIQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPV0</accession>
    <name>A0A8B7ZPV0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Chromatin assembly factor 1 subunit B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17" type="primary">LOC110988438</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107613.1">
        <property type="nucleotide sequence ID" value="XM_022251921.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107614.1">
        <property type="nucleotide sequence ID" value="XM_022251922.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107615.1">
        <property type="nucleotide sequence ID" value="XM_022251923.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107616.1">
        <property type="nucleotide sequence ID" value="XM_022251924.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107617.1">
        <property type="nucleotide sequence ID" value="XM_022251925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPV0"/>
    <dbReference type="GeneID" id="110988438"/>
    <dbReference type="KEGG" id="aplc:110988438"/>
    <dbReference type="OMA" id="CIVSNLH"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000852">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="521"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="659"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022107613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022107614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022107615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022107616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022107617.1"/>
        </source>
    </evidence>
    <sequence length="683" mass="73738" checksum="D453200372ABBEA2" modified="2022-01-19" version="1">MKLDTPEISWHGREPIYSVDFQPCNSGASKKEPRRLATAGCGTDGNLRIWYIKINNDGKAMAEFASNLSRHTKSVNVVRFSPDGQILASGGDDCLVILWKLTDTQGGSSAFGKEDEECKEGWTAFKMLRGHLEDVYDLSWSPSGSRLLSGSVDNSAIIWDVAKGEKLVIFKDHRSFVQGVAWDPLGKYCATLSCDRSFRLYNLNNNRCAFNITKMSLATTTNSGEGITKQCRMFHDDSMRSFFRRLTFSPDGQLLIVPSGCLEMGEVSPSCNTTYMFTRSSIPRPAAHLPGPPKATLAVRCCPVFFELRKADEETQEATENSTKEERMDTSEVTGPNKDPVEAEKADATKETASSAESVQNSKEPQSLFSLPYRIAFAVATEDSILLYDTQQTIPFGLISNIHYHQLSDVSWSSDGQILVVSSTDGYCSLVTFEEGEIGVPYKTAPVVPVATVGSNVTAASETACGKPPTSVIPASQASFGQAKPVTSETLAGMNVHKVTANQGGSASAVAKVEPRRIALTTLGTSTAPKTTGSQPRRISTTQLSSPPSSQSNPCPTVSTNQNPTATGYSTPNSQMQTVHKSPQGVQPRRIQLTTLSISKPPVSEVSPTNKSVAMVTTPVSTINQMPLTTDIQGTQSLRKGMAEPVLDNKKIEAINVPEGDSPMEGVTEIAPKSQDKDVMLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZS25</accession>
    <name>A0A8B7ZS25_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Regulator of nonsense transcripts 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110988724</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108204.1">
        <property type="nucleotide sequence ID" value="XM_022252512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZS25"/>
    <dbReference type="GeneID" id="110988724"/>
    <dbReference type="KEGG" id="aplc:110988724"/>
    <dbReference type="CTD" id="5976"/>
    <dbReference type="OMA" id="QYMQMNG"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21407">
        <property type="entry name" value="1B_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18039">
        <property type="entry name" value="DEXXQc_UPF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21400">
        <property type="entry name" value="ZBD_UPF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000097">
        <property type="entry name" value="Regulator of nonsense transcripts 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040812">
        <property type="entry name" value="UPF1_1B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018999">
        <property type="entry name" value="UPF1_CH/ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF364">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18141">
        <property type="entry name" value="UPF1_1B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09416">
        <property type="entry name" value="UPF1_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51997">
        <property type="entry name" value="UPF1_CH_RICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Upf1" evidence="13">
        <location>
            <begin position="106"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="C3H" evidence="11">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="CC/SHH/C" evidence="11">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="C4" evidence="11">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="984"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1075"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1039"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1075"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1130"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022108204.1"/>
        </source>
    </evidence>
    <sequence length="1147" mass="126794" checksum="E63D545318BAE806" modified="2022-01-19" version="1">MSVDAYGPSSQSLTFLDTEDGELLGADTQGTDFEYNVGDFTLPSQTQTQSQASQLDVVSQSQSQAGLSLDTKPAQQNGFVEDGVASTVQTLKELTFEEDEEETYYTKDLPDHACRYCGIHDPAAVVLCNTTKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHRDSPVGETALECYNCGCRNVFLLGFIPAKVDSVVVLLCRQPCATQSNLKDMNWDPSQWQPLIQDRCFLGWLVKVPSEQEQLRARQISAAQINRLEELWKNNSEATLEDLEKPGADEEPASVMLRYEDAYTYQNIFGPLVKMEADYDRRTKENQNQSNISVRWDIGLNRKTRAFFNFPKKEDLKLMQGDELRVRYLGDLQEPWSGVGHVVKIPDNYGDEICIELKSNAKVPVNCITNFVVDFVWKSTSFDRMQSALKTLAVDETAVSSYLYHKLLGHEVENMVIKSSLPKRFSAPNLPELNHSQVSAVRTVLTRPLSLIQGPPGTGKTVTSASIVYHLAKQGLGQVLVCAPSNIAVDQLTEKIHKTGLKVVRLSAKSREAIDSPVSFLTLHKQVRNMEGSEEQTKLQALKDEIGELSSADEKRYRTLKRNSERELLQNADVICCTCVGAGDPRLARFRFRAVLIDESTQATEPECLIPVVLGCKQVILVGDHCQLGPVVMCKKAANAGLSQSLFERLVVLGIRPIRLQVQYRMHPSLSAFPSNIFYEGSLQNGVSAADRIAKAVEFPWPQPDKPMFFYATSGQEEISSSGTSFLNRTEASNVEKITTSFLRAGVKPEQIGIITPYEGQRAFIVQYMQYSGPLNVKLYQEVEIASVDAFQGREKDYVILSCVRANDHQGIGFLNDPRRLNVALTRCRFGVIIVGNPKVLSRHPLWNHLLTYYKEQKVLVEGPLNNLKESLIQFSKPRKLVNTANPGGRFMTTAMFSAKEAMIPGSIYDRSGMMNGDSSRYVPGPGRIHDQMGYIQQGSAQFGGANLPMPVNMFMPPPPQPGAHFFNQGMRGGGPSPMGGQQVPQQRGKGAPPYSKRRGKTPGQQQQGVHGRGPQPGVGGATQGGASQNMSQYNLSMQSQEGTMAFSQGPLTQGMSMSQPGLSQAGFSQPGLSQPGLSQPELSQDSYLGEEFKSQMDAALSQDSTYQGDRNYQHGFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSA3</accession>
    <name>A0A8B7ZSA3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Paired box protein Pax-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110987687</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106331.1">
        <property type="nucleotide sequence ID" value="XM_022250639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSA3"/>
    <dbReference type="GeneID" id="110987687"/>
    <dbReference type="KEGG" id="aplc:110987687"/>
    <dbReference type="CTD" id="5080"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000069">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000028">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="15">
        <location>
            <begin position="37"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="237"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="239"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="362"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022106331.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="51648" checksum="6E013331A6F42A48" modified="2022-01-19" version="1">MAQQNGVETTTANPGSVSPQGQNDSGTKSKKGNRSRGHSGINQLGGMFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPLVVSRVAHYKRECPSIFAWEIRDRLLAEKVCTQENIPSVSSINRVLRSLAAEKNMGHDAMFDKLRMLNGQWPRPGTWYSPNAAMPGQHMNHVHEVESSCKKEGDVDLKDDDSEEAQARLRLKRKLQRNRTSFTAQQIEELEKEFERTHYPDVFARERLAQKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQQTEASPQSSSHLPISNLGGFSNISSVYQPIAQPSAPMVPRTAESYSALPPVPSFSMATAPNLNVQPPRDSGSYRSMMGSVSHGYHHESLYGSPNQHHAMQSHHVPHSSHGHMQSHHMNSACNNGAFSSLISPGVSVPVQVPGGNSNDSHSSQYWPRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSF5</accession>
    <name>A0A8B7ZSF5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110988801</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108344.1">
        <property type="nucleotide sequence ID" value="XM_022252652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSF5"/>
    <dbReference type="GeneID" id="110988801"/>
    <dbReference type="KEGG" id="aplc:110988801"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF76">
        <property type="entry name" value="PROTEIN NUBBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="11">
        <location>
            <begin position="494"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="590"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="592"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="821"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022108344.1"/>
        </source>
    </evidence>
    <sequence length="836" mass="87383" checksum="D9F3F86CE3AB44E7" modified="2022-01-19" version="1">MSRDMSKSDAARGTGQRNVEVLIFKMGDPSANKQQEEQRAEAQQNTSMSSETTTEATGEAGSATAASTTVTTASAAAVVAAAAAAAKTQAGAAMVQQTVTQVPVAATSLSIPMLQAQLASSGAQQIAQQIQAQAQAQPQFIVNAAPQMLLQGLPLAQAVTQKQQPQVFSLQGLPLSQATAAAAMAAAAQKVQAQPIAVSNANLIQQGNLSRILQGQQALQTQLTSQPQSSAAAVVAAAAASQSQAQTTVQATSQAAAAATTVPVTLAQALSAQQLQLLQQQAAAAGPVQLPFTDLTKMWQPGSQMPTQIPGQVGGQLQQQQQQQQQQQQQLQQQQQQQAKISTQNVVPGTSLQQISTTDLQQLQQLQQQNPMQQYVFLQTGQQTNMPQYVLLQPKKVAPNVQQQIFLQQQANQQSGLLSQPQTSLLPQIQGQQNLIQGQTFIGAQAVQQPAVTLATVSATQSGATIVATAPAITAQQQLQIVQAQKTSAIQQAEESTDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGNDFSQTTISRFEALNLSFKNMCKLKPLLQKWLDDADSTISNPSLLGGGTGMDSQDALGRRRKKRTSIETNIRVSLERAFIHNPKPTSEEIMILADTLGMEKEVVRVWFCNRRQKEKRINPPTVNLANLSYNGASPLVSPSAATSAAATASQLNSNHGTGGLPIGSPITTTNAALVTGISSGGVNMNAAGLITSVAQAVANNNNAALGSFKGAASTVTVNSPLTNAVNSVSVPATSLVAKTLQLSQGGAAAAPVSVATNGAQQVSAPINTTANTLPMDVVTMSVTSHDNSSPVTVPVETSVVGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZT49</accession>
    <name>A0A8B7ZT49_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987843</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Directly interacts with POMP. Interacts with ABCB1 and TAP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106646.1">
        <property type="nucleotide sequence ID" value="XM_022250954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZT49"/>
    <dbReference type="GeneID" id="110987843"/>
    <dbReference type="KEGG" id="aplc:110987843"/>
    <dbReference type="CTD" id="5693"/>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000030">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106646.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30439" checksum="3BBA525EB8B1B432" modified="2022-01-19" version="1">MALENVCGLNFHKGSGGFGAKIRQCTDVNLLQDDPLENPKFTVPAVAEPAEFLKNFSGGDGSSPKIEFLHGTTTLGFKFQHGVIIAVDSRATAGNYIASQTVKKVIEINPYLLGTMAGGAADCMFWERVLAERCRVYELRNKERISVAAASKLLANILYNYKGMGLSVGTMICGWDKTGPGLYYVDSDGSRLTHKLFSVGSGSPYAYGVLDSGHRDDLTVPEAYELGQRAIYHATHRDAYSGGVVNLYHMKETGWEFISQTDTKLLHYQYQDEKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU73</accession>
    <name>A0A8B7ZU73_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase</fullName>
            <ecNumber evidence="14">2.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">LOC110989215</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81643"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="Rhea" id="RHEA-COMP:19720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="ChEBI" id="CHEBI:231970"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-O-[N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81659"/>
            <dbReference type="Rhea" id="RHEA-COMP:14417"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:139598"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81660"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminyl-(2-&gt;6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11136"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:140764"/>
            <dbReference type="EC" id="2.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11137"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022109112.1">
        <property type="nucleotide sequence ID" value="XM_022253420.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109113.1">
        <property type="nucleotide sequence ID" value="XM_022253421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZU73"/>
    <dbReference type="GeneID" id="110989215"/>
    <dbReference type="KEGG" id="aplc:110989215"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000015">
        <property type="entry name" value="Lactosylceramide alpha-2,3-sialyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941:SF6">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665753" description="alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase" evidence="17">
        <location>
            <begin position="25"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022109112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022109113.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="57679" checksum="95404D558DE43BC1" modified="2022-01-19" version="1">MPRAFQSTTGIIMLFRVLFSGCDRVRVYSMAWAQYNDNFTLYYYDREFNFSQMARNSHDTKNFGIHLYHRARLKEGRRAVGRKACVSEQPILTAQEDILVLVTMATQKCAAQVCVFGVVAVLGVLYLCQRIPTIMSRLSLTADSVSSNSRYLVELSNQPSIKSPNTTSRAKYQDWKYLTLLLPHEDPKDIQLRQEHTFRINPAFRKSTCPVSLQIKMKDTDWTSDIYHPEIHILMNEQLLDRSEYERLLPYLIPYGYKSLPSPFPYDDVARILSLFPAAESIFEFHGQRRPTCLRCAVVGNGGILKGSSRGMEIDDHHMVFRVNNALRRGHETDVGNRTTHYFFFDRSLRDLEKRDVPRDKGIKYVFVPCERDDYLYIKRVVRGLEPKLHARAADVRILHPDFIRYVQRIWMGLPQISPYFRPSTGSLMLFTALHAGCDSVQVYGMGYQPKYSLYYFDNEYRAHNISTSVHDLSKEISLVKLLHEAEIIDWYQRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUC0</accession>
    <name>A0A8B7ZUC0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110989165</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109019.1">
        <property type="nucleotide sequence ID" value="XM_022253327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUC0"/>
    <dbReference type="GeneID" id="110989165"/>
    <dbReference type="KEGG" id="aplc:110989165"/>
    <dbReference type="CTD" id="7411"/>
    <dbReference type="OMA" id="YNWDVAQ"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022109019.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21840" checksum="E8FEB55D2DB2E959" modified="2022-01-19" version="1">MMALASEEDSKSAKKMKSTSHSGIPEAVFLEDVDAFMQKPENADPTAVVQRLDEQHNKYKFMELNLLQKKKRLRSQIPDIKNTLEIVQHMRSKQGSGEEMDTQFLLADQVYAKASIPPSERVCLWLGANVMLEYTIEDAESLLTSNLSAARESLLQVDTDLDFLRDQYTTTEVNMARVYNYGVKKRQGAQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWR4</accession>
    <name>A0A8B7ZWR4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Transmembrane protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110989720</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109987.1">
        <property type="nucleotide sequence ID" value="XM_022254295.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109988.1">
        <property type="nucleotide sequence ID" value="XM_022254296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWR4"/>
    <dbReference type="GeneID" id="110989720"/>
    <dbReference type="KEGG" id="aplc:110989720"/>
    <dbReference type="OMA" id="CETEMWA"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109988.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39734" checksum="BB82186D438882F2" modified="2022-01-19" version="1">MTILSKSKAIFVRLLFGAHGTLAVIALVNITEIRWFYLAECLVAVSLLEAFVTLKVNKHAEWKWFLPSVFLYLLWIVPPIVLLESYAMDYRQFRLDMSENGRCFVDFNDVCVGQNGSIDYVDNSEVDMSNGVLDQTTYDEARHYALVFQQTMMLVLIGGRWLGPKGALTRDQLSQLLLALTGMAADMLEFVTETVKLEETACDYLLIYIILGIWAWSLLQFTLGLTATKQKKTRVVGPSPSARNPITSIAACCETEMWALMVSVVMQDGPYLTARLYIMFTVQNFGQTMIFFTAKNGILFLLQVYRLYVVIIERRRAGREGRKSRDEEEEEDSAFEIKEARTPTTPINGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWT8</accession>
    <name>A0A8B7ZWT8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Collagen alpha-1(X) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110989737</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022110012.1">
        <property type="nucleotide sequence ID" value="XM_022254320.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110013.1">
        <property type="nucleotide sequence ID" value="XM_022254321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWT8"/>
    <dbReference type="GeneID" id="110989737"/>
    <dbReference type="KEGG" id="aplc:110989737"/>
    <dbReference type="OMA" id="RKNDEWV"/>
    <dbReference type="OrthoDB" id="8044756at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665762" evidence="5">
        <location>
            <begin position="24"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="135"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022110012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022110013.1"/>
        </source>
    </evidence>
    <sequence length="269" mass="27552" checksum="465D7E0A29A26F56" modified="2022-01-19" version="1">MQLCFATTLTIAILLGNSIKLRAAITGPATAESDGPGSQVCPMCCQGPAGTPGIPGLPGNQGQFGPAGAKGDAGVKGQKGEIGPTGAVGNPGPKGDDGLGLPGKVGPRGPPGVVGAIGESGAKGQKGEPGETPDTSVHQVAFTVIRTSPSDISTSHATLLPFQQAKRLLPGTSFDLGTGTFTCNVPGTYVFTFSVYKYSSNQLFVHLRKNDEWVVSGGSYDSRHSEQVSASAVLVLQRGDSVYLTMYGRATSASTYAYTSFTGFLLYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX80</accession>
    <name>A0A8B7ZX80_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110989351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022109370.1">
        <property type="nucleotide sequence ID" value="XM_022253678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX80"/>
    <dbReference type="GeneID" id="110989351"/>
    <dbReference type="KEGG" id="aplc:110989351"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF23">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE USP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="495"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="355"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022109370.1"/>
        </source>
    </evidence>
    <sequence length="898" mass="100058" checksum="98B5A7A73FAD1C68" modified="2022-01-19" version="1">MREVDKKLAKRAAKRAARAEAARKEKERLENIRCEKERKERLKEARKQRKEAAKLEKLEKKKQRKAKKIAKEARRAEENLDPIASNGKGDSISKREKEKISLYKSFGCQEKVADTSPVSAPSKTSIHPYPSAKHRSQSPPSGSPKIPPGSPHFQAALIQTVPDDGEAVIHDAIPSVETPLSTGDDVAGMSYRAPAQRHSPVTVQRRSSSRPSSPARLVTPSSVTRLSPPAVSRTPHPPGGYSRTDYVPSVSRTCTSSRRSGILDDSPAEKSRFSRYGGTDINANSRIDPLSKLYGSRQASPAKIPQQTRQQPVRAVHPSTETVSKSSKLSHRYSNHRNYSTEDDLNDDVINLHINDTSGSLSPASTTSSRRSSFTMGQRSRGSSSDLRCPPIPGASPPTSATTPKVTRRVSGSYNTEYKPTFVSNASRPPPTTNGPKVPSVSRTKASSILEESNSEKVKEEEPLQSAFSSAEHSVLGTGRTGNTYNGKSVNGGMIGLANLGNTCYMNSILQCLAQNKDLREYFLTNTYLDDINRRSPRQGTLVKSFAEVMKEIWNPKYKSVVTPNSLQLAFQRIAKHFGPGKQQDAQEFLCYFLCELHDETNTAPRKRGSEPDIPDDISEDAKAKLAWGRYCAHNNSIFSRLFVGQLKSTLECQTCRNRSVTFDIFWDISLPVPEQVKSYQRRASWERDNQSVKHSFDIKDCLNKFTEAEVLDGDNMVTCEKCKKKRVFTKTFSIQRFPKHLVLHLKRFSGLRAKLTTFVDFPLTGLDMSRYLADSAADTGLLNLTTAINHIEPLSHDLFYLVWKMCGTPPVVSMDEMLSLQDQKNNPSLDQLSSQYNLGGVSQHSGSMLGGHYIAYAKHLQNKKWHCYDDTRVDSINEKSVPSSYAYVLFYEQANQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXD8</accession>
    <name>A0A8B7ZXD8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 116-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110989767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        </source>
    </evidence>
    <sequence length="644" mass="71390" checksum="71F27B4167684332" modified="2022-01-19" version="1">MATGSAVTPALETISRHHLECPICSERFQRPKILDCLHSFCEQCLLTYCNTKHQGCTEIPCPVCQRETQLQEAGVGGMKTNFYLIGLVEEIELQEKLVCSSETKLLCDVCEEDNEVTHRCVDCEQNICSLCCKLHLRFAVSQGHTISTLEDIREREISIKNKSAETHPTCTTHEGEVTRFFCTTCEMLICRDCTVIDHCKPYHTHTDTKEASSTYKTSVTDLFSHLEETLKQVHESSELVSVMRQDLDIKAETAISEVQGRTIEIRAWATAQETRIIDNITSIQKDRLEKLSEYEKAMSLASERIQHSLETAREVTRTAADSEFLSLYATINKDLKLLAGQTIPRVDKRLGFLKFKPSEGVLGDISLGKVVTEGKWEQRCMFGSKGSGPGELDGAMGICARQPDEVAVGDDWNKRVVIYSIDGDLKSTIQMDGYPRGITATRTDNRLVVVEEGASHVMHVKVFDKDNTLAFQFPTVPPSEVGKTAVDLHRLAIKADGTIVVGDTKRMVLTEHSPTDGELRSTIPVKIKPHFLAVECSGRFVISDCSKTVGLVDGNGESLFTIKPTIDGEVAECCSGVCADSTGIYVAMHNGNYTGHVHHYDPQGGFLHCIAQGLFHPKGITFTADGQLAIADYYSVKMYMLQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZZ4</accession>
    <name>A0A8B7ZZZ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable glucuronokinase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111078.1">
        <property type="nucleotide sequence ID" value="XM_022255386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZZ4"/>
    <dbReference type="GeneID" id="110990395"/>
    <dbReference type="KEGG" id="aplc:110990395"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047940">
        <property type="term" value="F:glucuronokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053034">
        <property type="entry name" value="Glucuronokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38710">
        <property type="entry name" value="WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38710:SF1">
        <property type="entry name" value="WITH PUTATIVE URIDYL PYROPHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111078.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18718" checksum="09D92E6A4748C17D" modified="2022-01-19" version="1">MSSELCSATFSIFSCDSEIIAGMQKFAELTDQAKEALEARDTQRLCDLMNANFDLRRSLYGDEVIGETNVRMIELARQFGSSSKFPGSGGAVIGICSDPQELPRLRATFQEEGFVFCQIIPRPESPPASPRCSPVSASPPPENPAQPPNGTDDALGPNNQEDTQTKASDELTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0V2</accession>
    <name>A0A8B8A0V2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Low-density lipoprotein receptor-related protein 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110989401</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109461.1">
        <property type="nucleotide sequence ID" value="XM_022253769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0V2"/>
    <dbReference type="GeneID" id="110989401"/>
    <dbReference type="KEGG" id="aplc:110989401"/>
    <dbReference type="OrthoDB" id="2019384at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="135"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="337"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022109461.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44355" checksum="CF3C6AB1B71B1C8D" modified="2022-01-19" version="1">MSCEWKLGASSGFIVISIVDFHLRSGDIVTVEGPGLELGDLATSPGNKVALSGTTPVTRVISRLPMINITMTTNAFMRGTGFKMKIEAFETTPSECSGEPDFQCEGSTLCISSRTVCDGLKDCPFAFDEQHCYECDGITINLQENIPYTFTSPNYPDRYPNSLNCQWEFRASSGFIVITILDFVTERRYDFVTIEGPGLELGDLTTGSGNKLSLTGNTAVTRVSSRLPIINISMTTNEFRRTRGFRMKIEAFKTWPSKCSGVPDFQCENSTFCISSRAVCNGLKNCPYGFDEQQCYSISCPEFFQCRETRECIFWDQVCDGTKHCLIGDDETNCDLCGENEIHLEEDLPYNLTSPNYPDRYPNYLSCHWEFSASNGFIVISILDFKTVTSSDFVTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1P3</accession>
    <name>A0A8B8A1P3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110989590</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110989590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109781.1">
        <property type="nucleotide sequence ID" value="XM_022254089.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989590"/>
    <dbReference type="KEGG" id="aplc:110989590"/>
    <dbReference type="OMA" id="DIIRAWG"/>
    <dbReference type="OrthoDB" id="192402at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042508">
        <property type="entry name" value="FBXW5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20995">
        <property type="entry name" value="F-BOX/WD REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20995:SF17">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="5"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="664"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="420"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="572"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="859"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="876"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109781.1"/>
        </source>
    </evidence>
    <sequence length="1122" mass="124351" checksum="43C9D1A2756C46B2" modified="2022-01-19" version="1">MEEESCIWLCLPDSLVLHIFSFLSSHELLRAAQVCKAWLCISHDELLWKALLYGEWRIDHCLSLPLGCPSYFREFRRLQCHVPCLEVQVLREHTDQVLHVSFSHNGKLFATCSKDGTIKVWRVGPPISLKYSRAMKDLFRWQYTQFSQFNANDTLLLVSGVHFGPNSTSGEIAVFNLKDDFALQARVLNKPYDIFGCWLNNTYLLSGKLHYLGHLSSCSALWLNKATQEVLSEQESVIMRLFKFLNVNASSVRSITVANCRNLGKGDDHDEPSVVGNYSEYDSSTQAGLNSSGPMPDSSESELDGKAGTGCYMYESDTEMTASESDTGQSGMDLLQVLSRDTRQGSSRDPGQGSSRDWGQGPSEQVKDRGGISASGAVPKSGAWPLLHQSQSDPCLPLDADQLRKARAIANINQMYQQQQQLLQQQSGQTSHQQGQSKEASSEAAPSSVLGQPAQSQPQEVCTKRSSPAKRDVSDVSGTPPDVLRKSLRIEPVHEGSQPGTLSSTSQGSSAASGRGQADSDACCTRLWLRVRKAEMRRGGENYDEDLFRILIEGIHPNDWTGQTEEHGDTGASWSTSDGHKPANSSKPGTSKEGVSTNAGEASHSLQPLDLRESQAVGVGSSHCSSSDAILSSPDCDQSSLTFAADSSSASDIIRAWGKHFTFGSTESLDEEPPIHYPDRCRGFSDSEITRGHEPLQQDNLPQQLQHQQHRQLQDSEDPMSSSXPDPSAGWLYPLGKFWGEASHSLQPLDLRESQSVGVGSSHCSSSDAILSSPDCDQSSLTFAADSSSASDIIRAWGKHFTFGSTESLDEEPPIHYPDRCRGFSDSEITRGHEPLQQDNLPQQLQHQQHRQLQDSEDPMSSSSLSDSQTQDHANHHAHHHHHRTKVRRRKVPAKVEHQHLIFTRGSLAYTPHQIGIKRIDANMADTLKGPLGVSMQPASDREEPGEGREPQGDGQDRPGELEFDKVDHVIELNGHAIGMALSPDHRYLYVNCRCWPRDYMIADPLTPPPIAQEIEIRVYDLINLTEVKRFHGHKAFSPNDEFNLIFLDVSDLYVASGAEDRHGYIWDRYYGNLLAKLPHRDVVNSVAFNPRDPEMMITASDDHTLKVWFSRHKAAVAKDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A251</accession>
    <name>A0A8B8A251_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear pore complex protein Nup205-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110991017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111764.1">
        <property type="nucleotide sequence ID" value="XM_022256072.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110991017"/>
    <dbReference type="KEGG" id="aplc:110991017"/>
    <dbReference type="CTD" id="23165"/>
    <dbReference type="OMA" id="WSQMFAE"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022111764.1"/>
        </source>
    </evidence>
    <sequence length="2072" mass="231295" checksum="59867E42FB95D02F" modified="2022-01-19" version="1">MADSKAVNLGSNLWSPFKELLRTVHAALSQKLPDAFYELDAAIRKHKPDFISLLQNPAKNAQHRLQIRKADVTGLVIEGQPGTKTFPRQFIDEALIISDLFDLNEYFAVELLLSGEQQQPHFPGLTRGLVAVLLYYDGRRSVINALQLLIQSRKGRTWTLELEDEVSDLTTRFTDELIRDGLMRKILTLLLETDVEKQMDKLGQARALGDARHRHEVMEMLKEIRSSLAECLFAWACQSAPSRQDAGLLIDHLRRHAGLEADGRLDGVTLSLLMACLYCLDVGGLTETRPEDRDELTKQLPVLNDAEFLPDLHQMIVKDEAEWACPGIAAVLRFAWALMLRNVAQQPEVDAMQDFIEEDEMIVDDAMKDNVFRFLTDAVVASGNFHQLEFCARRLHGLVTDFIVQMPLKVKDMRNRGDDVGRTIMAYELEGVEPPSTLPRHFQDFMKLLGALYGNDPLGLELPLEYWCTPDHSSSPSASATYVSHPHQRQSPRQASLFKFIRMAGDLLPPSLYVAYIDMLSGLANGEESARHCFNLLKMNGMGSGGSSSTVSWDHFFLSINRYYTSLRQEATSSPRPEVAQAHAMHRYSVVKGITPQEMEGLLAVLRLTQVIAKWDETARLALCENQSWLPIVLLLGLISCSVPPKLKGQCLRTLATLAHSPEVGAKLWQSLEVSQVIPTVVQPGSPASGIPVELDEIESSNEEYPLTCGFLDLMSSLLELPVPAALGAGYRPPGFDPYLEFLRDTVFLKYRWRAYRDPGEKWEVAAGVTEIFCKLLQDYEPQPQDFVDHPVEIQGGGLGMANKPPGYHLMEHMLNDSAMLRLILQIIDEVTQILDQYRLTIPGKSQMVKCALMCLQMVQLTLEKQNAFVDLVRMQGSGVMVSTMDELLMAINPRSETADHLVNIAKFVTHGDTHPKHALASTRILHSTVRASNKQPDIVGLFTAKEEVRRNLLRGFVDCLETEDPEDLAAAASEDLPTDEDTLAEEDTAKVRSATRLYILRLLLYSLEQPSPNLAHFLLGYEYRKPASKTNLQEPGVLGSPRTCLHSILNVLSLDRDVNARLGPLAIHAMPRLAELAYEMIYRLCANRETSDPTMRYLRASQDFFYSQLRHLPFSGSAAGNVEEGLRLNQQSWLLKAIATEIRLTAVNRQRSHLQRLLRLLLEDSPSLLFGDEETDEQGVADVSLIAEHGALGMSTMYQPGQSRVTGTQVRRKILTLLDSIDLVQDLPPSLRLEYSDPVTMEKTIGAFELPAERGGVASLCDVRQLHRFLTANLNSLQGASAIGQRPLVMQEIEAVLLNVTKRNNFRQGLAAKRHNFDAWRHVAEVVLTSCPAEVLPLATKQKVVVELLQELLSKVCEEEVTPDLASPVGGVLLTLMTSLRECILTDETESIPQLLSAQYVRAMDGSSVMGGGAGPAVESRAPLRGLGVEVVSLTAILKELLKFIVISGGSQQRTRANLYGTLLNYLQIPRKPREIPTMQDGSTVLNSALLDEYETITAANLATMQEYGEGVMELVCRDASDGLGVGRMLALSVIDTIVGIDKRGDWLSFLSAKGYLRHLVENLAQEDQSLLESLQPTPEPLRALFIYESQMSLLEKIALNPVGAQALLRAGLMARLASCRFLDLRPEHSTQSRLRMGSTGLEPVEVETFIPSVMQRYRQLLFPVLRLCLAILTSLGSQHKEAASQVLHFVVSHSDIFTAILREQHAELQLEPLQELALATSVICTVAADITFYDLPSDPSMPNHVPIQTHLSRIHRQIMALVPRFCALDRWLRDLKRLETAPQGGDAPSHTPHHKDSIRQVLLEISRNVIGYCKNIVVLSGSTAKDSQILFTPNLQEATARDYQAIEGVHLSSLDLTRPPTLGIIVRHLRQAASEFMSTMDSHQQHLHKLKNIADLSTEELKELIQTASGPTSEKLSSSHRLQLATRKLADTVRQKADELAVLYYMIECSLFLVWRHLEFYLLYCQTSKDSLLHKLSLPRQQPRNLADPNRFLLDGAGDDPSHTPISPVLLGITNDDIKQLRVDATSCLSEMLLKRTREIEAQFIRGQSRYTFISVLVRRIRRLLMLGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3E5</accession>
    <name>A0A8B8A3E5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Galactosylceramide sulfotransferase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110991248</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the galactose-3-O-sulfotransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112243.1">
        <property type="nucleotide sequence ID" value="XM_022256551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3E5"/>
    <dbReference type="GeneID" id="110991248"/>
    <dbReference type="KEGG" id="aplc:110991248"/>
    <dbReference type="OrthoDB" id="514299at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001733">
        <property type="term" value="F:galactosylceramide sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009729">
        <property type="entry name" value="Gal-3-0_sulfotransfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14647:SF86">
        <property type="entry name" value="GALACTOSE-3-O-SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06990">
        <property type="entry name" value="Gal-3-0_sulfotr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022112243.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="60394" checksum="77132A7235ED2389" modified="2022-01-19" version="1">MVMGKTCTSSAFFVIFIMGLMSVTLLIAQSGHLFRKRDHIQKQEHGHRTRMLVHRSREALKHYHAWTRGQHHLPREEENAIPGKDDIPLLRHRAWSQRQHLLRRPQEPAVLREEEDTLQLARAWSVKRDYLPKIQKGSHFKEFGADAVITTNNQRWTNWSTRHCTPRRDIAFVKMHKCSSSTIQNILFRYGERHSLDFVLPPTHNILGRTYFDKRFMIQFPVDKYNILCHHTRFSAKGFAEVMSPNAVYTTILRDPVEMYESSFTYNDIAFRFNLSPEKGLEQFMQMPLYFYNRNIYTNSHVKNPMLYDLGLPESGQFSPSKINQKIMELTRQFDLVMITEYFDESVVLLRHLMCWEIDDMVYFILNARSKSSVPTLSLDLAEKIRDWNAGDVRLYDVFNKTFWKRVEVFGAERMHKEVQALQERVGFFRDYCIERVVDNDRHVWHPYGVKIDSFKLKPETQHDPLCNRMIKPELLYTRALRITQLRKYNMGDSIDLMTYNKTSKRPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3W3</accession>
    <name>A0A8B8A3W3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110990840</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110990840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111620.1">
        <property type="nucleotide sequence ID" value="XM_022255928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3W3"/>
    <dbReference type="GeneID" id="110990840"/>
    <dbReference type="KEGG" id="aplc:110990840"/>
    <dbReference type="OMA" id="GKEMSIN"/>
    <dbReference type="OrthoDB" id="10038928at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033151">
        <property type="term" value="P:V(D)J recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024627">
        <property type="entry name" value="RAG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058552">
        <property type="entry name" value="RAG1_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058553">
        <property type="entry name" value="RAG1_pre-RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058554">
        <property type="entry name" value="RAG1_RNase_H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11539:SF0">
        <property type="entry name" value="V(D)J RECOMBINATION-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11539">
        <property type="entry name" value="VDJ RECOMBINATION ACTIVATING PROTEIN 1 RAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26024">
        <property type="entry name" value="RAG1_DNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26025">
        <property type="entry name" value="RAG1_pre-RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26100">
        <property type="entry name" value="RAG1_RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V(D)J recombination-activating protein 1 DNA-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="V(D)J recombination-activating protein 1 pre-RNase H" evidence="2">
        <location>
            <begin position="56"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="V(D)J recombination-activating protein 1 RNase H" evidence="3">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022111620.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26720" checksum="50D135B465BDA4CE" modified="2022-01-19" version="1">MRVTTKTSKSHYEAQYKKFRTKGVSILKPPHVLNELEKTFMPGNVLFRLEGGRDVIHHTPVKVGKSHVHYGEVSFEPLDLNQEDHPGLETPFPNMKGVAWPYPHALAKTLVELDAEIAAGMEKAGIDPDNDHYVLTTIKDGADGMGDISITKSVRDRLLPDKAFRAAFAVIKSEVEKDGERVTVYEPDAPDSTFITRPLIEAIADENNKSICLSPTGWYGAGSSHVAIKGNGCQCWCSMEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A480</accession>
    <name>A0A8B8A480_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110990170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110726.1">
        <property type="nucleotide sequence ID" value="XM_022255034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A480"/>
    <dbReference type="GeneID" id="110990170"/>
    <dbReference type="KEGG" id="aplc:110990170"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110726.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="28390" checksum="F6ED1EDDB6765E46" modified="2022-01-19" version="1">MVSAKVHKELLRMAEERANRAEMKAMALERELRFLMEEQSLAGASSGDPPKIPPRRKEVKYPASSVGIRTSPKYFQKHSTLYSRGNLGAKRGQPAVSGGRTAGGGGTSTASNNRPTKPQTRTWSLSRLRKVEASKTTKEAKKENGKEGKNSGKVSFLQRVQSRVTSAQTKSEVQKSLFDRMQSRFFAKSSPKSSAAPASSSCDLPDLSSLEEESSKSEYEVPMDPVQRFAGTPLIDMVDLICIPKTLHDQAQLDETPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A4Z9</accession>
    <name>A0A8B8A4Z9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110991112 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110991112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111980.1">
        <property type="nucleotide sequence ID" value="XM_022256288.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110991112"/>
    <dbReference type="KEGG" id="aplc:110991112"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034990386" evidence="4">
        <location>
            <begin position="25"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1659"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="212"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="296"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="382"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="473"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="559"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="649"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="825"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="915"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="921"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1759"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1792"/>
            <end position="1802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022111980.1"/>
        </source>
    </evidence>
    <sequence length="1833" mass="192476" checksum="9A4BE9B0EE7BBE08" modified="2022-01-19" version="1">MDILRGKACMLVACVLAMAFVIEAEPPTFTSCRNYITPAAGELPQAVNFPLPEAQDPGGNLVQVSCSHRPGDKFPLGKTQVTCNATVGSETSTCKFKVGVGDGVNCTRDLNECVCRGETCTCFKGFTGIDCAIEDGTVCTGPSTPSDGCGNTCPAVSCRCERGWEGPSCNFVDDGSSCFSGVGSPPHCEECFIGDSPPCICEKGWQGIRCENDYLPPVFVSCPPDIFMKAGSGEDRAVVTWDDPRAVDNSGAEPNIVCDRTSGSWFSGTSLVTCTASDGTGNSVSDCIFNVTVTDEKAPVMTCPASGSWNVDSGADVATVIWSPLPEATDNIDGKLQVTCTDALGNVVNSGDEFLVGETSVFCLASDKSGNQGRCGFSITVVDNEGPIVTCPSSVTQNVETGKADAAVKWSPLPSAEDAVEGPVPTVVCTDEGGKAAESGNRFPAGNTMVTCSAMDSVGNKGNCSFLIIILDNEAPIMTCPDDIVRNVDAGKAVATVDWPIMPQANDTVDGLLAVTCSDGSGGLVSSGDEFPVDVTMVTCTASDTSHNEGTCSFLITVIDNEDPFIACPENIFQDLDAGSDVGTVHWPTQPSANDTVDGSLAVTCTDDSGIVVKSGDTFSVGATIVTCKAIDGSGNEANCSFTINLKDVEGPVVTCPKDSRQNVEPGRASAAVDWSPSPSAEDVVDGLVPNLTCKAEDGKLVESGGRFPVGKTKITCLAVDSARNEGNCSFVITVVDNESPVFTCLISNITENVSPGLAIGIIHWPSVPFANDTVDGPVAVSCFDSLGKLVSSGDPFAVGVTVVTCKASDSSGNEASCRFTITVIDNEGPVMTCPRNVSQDLDPGSSAGVVVWPTLPLASDTVDGFLTVTCENDSGDPVSSGDEFPVGVTVVTCEATDDSGNKGRCDFAITVKDNEDPVVTCPNSSTQNVEPGKADAAVDWSPSPSAEDNVDGLVPNVTCVDKSGKTIESGGRFPAGDTTITCLAVDSSQNEGNCTFFIKIKDNEAPVMTCPGNMSSNVDSGSAVGTIHWPTVPSANDTVDGPLPVTCKDDTGRLVSSGDEFPVGATTVKCEAADSSGNQDRCSFVVTVTDSEAPEMTCPKDIIQAAGPGETSTSVDWPTLPTANDTVDGLLTVTCSDDLGRLVSSGDAFPIGITVVTCRAADDSDNEANCSFAITVPECGDEETCQNGGTFLESFCNCSCPSPYTGKTCTACEPCQNGGHSQDPDTCACQCPEVYAGLLCSECKECVNGGNQDKDTCVCDCFNSYMGVLCDVCPPDIKCDNAGQFEEAACRCNCPPPWTGPTCSECIPCAHGGTDQDPDTCLCDCPGAYLPPVCAACGGQAECQNGGEFSEVSCNCTCPSPFTGKTCTECEPCQNGGSYQNKFMCVCDCPYFHTDPLCAVCPLGFVCLNGGTRREATCSCECANGWRAKDCSERVPNVPDDEYPVSPIWTVVKKKVSFEIAVIAPIYNGTVCDPRISKFSDACIALVTEFKLSVEIEYKFVAGFSQVVINQEDLRAGSVVVPHEVIYNYEEMTPTTRGISANALYGETVGKAVVRGYIGKLKVATGCEDCMAPQDHTYICDAEPPECAPGLMLTERAEGGEGTCYYVCRSKCKLDTTYCGDGTCRQEQGSKDISCSCPQSSAVMYSGAKCQNQVQLTWLYVGVSVGVVSILVLIVVLSVCLWRSKGLVDRLQEEDEEKVVLGKPMSDELMKELNSYCNNNNGSTGETYFHKPPSGESTRPSLYAQISQEHKRNRAIKNGQAPGAGSGAKVGGLRAHLSPGSPKYEAQIKPNDFDGSRSPRGERRPWYFWGKMSLPKKRDIKMIPMTSETGRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q3C2C1</accession>
    <name>PA22_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName>Phospholipase A2 AP-PLA2-II</fullName>
            <shortName>PLA2</shortName>
            <ecNumber>3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Phosphatidylcholine 2-acylhydrolase 2</fullName>
        </alternativeName>
    </protein>
    <organism>
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2006" name="Comp. Biochem. Physiol." volume="143B" first="54" last="60">
            <title>Molecular cloning of two toxic phospholipases A2 from the crown-of-thorns starfish Acanthaster planci venom.</title>
            <authorList>
                <person name="Ota E."/>
                <person name="Nagai H."/>
                <person name="Nagashima Y."/>
                <person name="Shiomi K."/>
            </authorList>
            <dbReference type="PubMed" id="16275035"/>
            <dbReference type="DOI" id="10.1016/j.cbpb.2005.10.001"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA]</scope>
        <scope>PROTEIN SEQUENCE OF 131-158</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1998" name="Toxicon" volume="36" first="589" last="599">
            <title>Purification and properties of phospholipases A2 from the crown-of-thorns starfish (Acanthaster planci) venom.</title>
            <authorList>
                <person name="Shiomi K.A."/>
                <person name="Kazama A."/>
                <person name="Shimakura K."/>
                <person name="Nagashima Y."/>
            </authorList>
            <dbReference type="PubMed" id="9643471"/>
            <dbReference type="DOI" id="10.1016/S0041-0101(97)00085-8"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 24-85</scope>
        <scope>FUNCTION</scope>
        <source>
            <tissue>Spine</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Starfish phospholipase A2 (PLA2) that has hemorrhagic and capillary permeability-increasing activities and hence is considered to be deeply involved in the local inflammation. Shows hemolytic activity only in the presence of phosphatidylcholine (PC). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="1">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text>Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="tissue specificity">
        <text>Expressed by the venom gland.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase A2 family. Group I subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4"/>
    <dbReference type="EMBL" id="AB211368">
        <property type="protein sequence ID" value="BAE46766.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q3C2C1"/>
    <dbReference type="SMR" id="Q3C2C1"/>
    <dbReference type="EnsemblMetazoa" id="XM_022223582.1">
        <property type="protein sequence ID" value="XP_022079274.1"/>
        <property type="gene ID" value="LOC110973093"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF51">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0204">Cytolysis</keyword>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0354">Hemolysis</keyword>
    <keyword id="KW-1200">Hemorrhagic toxin</keyword>
    <keyword id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0442">Lipid degradation</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0800">Toxin</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000272035" evidence="4">
        <location>
            <begin position="17"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000272036" description="Phospholipase A2 AP-PLA2-II">
        <location>
            <begin position="24"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="51"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="68"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="75"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="85"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AA sequence." evidence="5" ref="2">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AA sequence." evidence="5" ref="2">
        <original>T</original>
        <variation>L</variation>
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="9643471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="158" mass="17490" checksum="A013B58205747C22" modified="2005-11-22" version="1" precursor="true">MKTFLILAMAVALAKAQSTDEITNLVQFGKLVMCLGNIGYTEGLEYDGYGCFCGKGGKGTPVDATDRCCEVHDNCYGQAVEEGKCWSVETYGTTYWYDQSTSGSCSIRCWEEGDYNSLVPRKACKAAICECDRKAAQCFADNRPTFNRKYLNYAKDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XF35</accession>
    <name>A0A8B7XF35_ACAPL</name>
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        <recommendedName>
            <fullName evidence="3">RWD domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110973129</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
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            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
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    </dbReference>
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        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="39"/>
            <end position="152"/>
        </location>
    </feature>
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        <source>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022079369.1"/>
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    </evidence>
    <sequence length="315" mass="35541" checksum="5A789DEF8287A402" modified="2022-01-19" version="1">MDALKFMFYHKRKRQELPFQQYGAIKSFGLDSVNSMADDEVKALQGIFCGDGEFELLLNSDGEQSFSICVTCQPSETTTVDQTSDTLKISLQCFLPSGYPHEPPSISLACGRVTKQSANQLQDELREYSKSLLGQPMIMELVYWLQKNGTRLTAALVKNRDTSNRKGGDDSTPYVTILHIDYMRSRVRYIKTLVSWAAELSLVGRLLFLHHLILVLLIGTEDCVKDFLMRLRTQKVDIDSSGRSCKERMLTVLMQGLHPRPSDSRLIDFQVRECSATEELEDVFLAAGLTDGLKSAVLPKFPHLQRSSCKNSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XG63</accession>
    <name>A0A8B7XG63_ACAPL</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110973069</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
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            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_022223534.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Retrotrans_Pao"/>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03564">
        <property type="entry name" value="DUF1759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1452"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079226.1"/>
        </source>
    </evidence>
    <sequence length="1786" mass="200783" checksum="5B728CDF85CE1E5E" modified="2022-01-19" version="1">MPVFCSNSAALPVCVDARSDPKISVPLHSQQVAVSQVQQTCYSIPPFTSGTTVCSTHSFPIPNTTVCSSLPNDTGNHSSAQVTPTTPIPSEPSPQGRPLPSTGVGTSLGQPVALKADPGINQNQMLSSMLAASAGGISMEIPVFNGGNPSEFRCFEAMVEGCIRPLVHLSELQKYFIVRSKLRGQPKKDVLGFEHHASPFTLAMSTLRKLYGDIGILIRSKIEQITSWPKLAAHDSKGLVELASTVSALVVQLESAPEGEAELKANSTACVLYSRLPHIHQTAFLKAMTNKGVRNFSLADINAWLQETSAVARKKIQLNESLKSDPSPGHHERRQRGAAAYHTKAGNQAARVHNKPVKVSHTSDLTESRPTKEKKPFPKHCPYCEGEHWLSRCDKFDKLSSSQRIEWIKANRRCWRCARQHREGQECDLRKPCRECSEIHLTVLHDLLKQPGYGSYYSSFDPNLSVFYGDGSPWHPKEVSLKILPIILYGNCTSLTTYCLLDDGSNFSMMPMEAAEALQLRGTATEIPIATARDACTPCRGQMLDFDIAPLDDPDMRIHVSNVFSSPMLRLSEHSVPAQDLQRRWPHLQNLPLHDCQKVTPLLLLGSDRPDLVIPRESRFGPENAPVAVKTRLGWALQGPTMRRGGRGKLHYQSSEQDAVLHENVCRLWNMDVQMYTQRKQVTRSKQDQRAVDLLEAKSTFVEIGNVRRVATPLLWRLGKPTFSCPASAVLPSLKRNEQRLLRDPDLAKIHCGKIQELKEGGLVRTVVNQGGDQEPESQWYIPHHVVRQNDKSRLVFNCAFRYQGESLNEDLLPGPTLGSSLVGVLLRFRKHPVAICGDIKAMFHCVSTLEADKSMLRFLWKEPNSDREPEELEWNVLPFGTTCSPCCASFALQKHVRDNVGDPDVLRSVLEAFYVDNCLDGKPTVDEAKQLVEKLRESLGAGGFPIVKWASNKPAVVADLQSEARSDNTERWLNFSGDTPEEVALGPRWNFERDVLTYQLQLSDWPILTRRAVLSDVMRCSGKDPLGYLMPFMVRGKILVQELWKRPWGWDDEIPDEGEEGIRAKHLRWRQELAQLKDVSLPRCYTPLHFNPATSSYQLHVFTDASEKAYGAVGYLRVMNEVGEVSAEFVMARSRLAPKRVQTMPRLELMAAVSGAELVELLEDELSIRARTTCWSDSTTVLAWINSESCRYNRFVGARVAEVQRLTNHVTWRYVESQNNPADDLTRGLPLQQIRDGSRWHRPFFLLQSETDWPQEPPKLTKEEARLEVKPDFFTGMMVTPQEKRPEIDVSCFDTWDGLVEGYSKALYQSQGEEGPPFLSADDRSKIERLLFQRVQTDCFQKDLVTLSAGKPVSNKSRLSCLCPEYDAESQLIRVGGRLRRATELDSNAKHPIVLDPKHPVTCLLIQEADCRLGHGGADMVLADLRRRFWIIRGRQSIRSLQSRCEGCIRRRGKPSIPKMADLPPSRLRIGKPAFYSTGVDCFGPFTVSLGRRSEQRWGIIWKCMTTRAVYLDLLDSLDADAFLMAFNRFRSRRGTPHEVLCDNGTNFKGGLTELTKAFSEMTPSLQEQLAKYKVRFKFNPPSAPHFGGTWEREVRSVKNALYAILGNRTVSAAVLYTSLVEVEALLNSKPLGYVSSDVADPDPITPFTLLLGRPDHAPPQVVYPDQYIHGRRRWRQCQALMQQFWKEFVDSYLPSMQARQKWRKEEDDLAVGNVVLMIDPHQVRASWPLARIIEVLPGDDGRVRAVRVESGGRVYTRPVAKLIRLPDETEDRAEVADPVSPNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGT2</accession>
    <name>A0A8B7XGT2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Alpha-1D adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110973459</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079998.1">
        <property type="nucleotide sequence ID" value="XM_022224306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGT2"/>
    <dbReference type="GeneID" id="110973459"/>
    <dbReference type="KEGG" id="aplc:110973459"/>
    <dbReference type="OMA" id="LPEWICK"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="48"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022079998.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40154" checksum="81B022F19E762B43" modified="2022-01-19" version="1">MDPRENETGMSEALQEGEDEIEFRFSDYNQRVTVAFIYFIISILGSFGNAMVILAVCLSHRLRTITNVFVVSLSVADMLTCVVLPFNAANLLDSDLDSSLLPEWICKAVAMVLYVCGGCSLYTLAAIAINRYILITKPVRTYRSLYSRRKTAVMVAVTWFVPFLVAFVPPLFGLGELGYAEKYGGCTHKTSNPLSHIYSIVQAVLFYPGPMTIIIICYVKIFRYVQRHCRQLASSHAGGSLSSVRKGDTNSDGNPNGPCKLEQQLASRKQINITKNLFCVVLAFAICVSPFGIALMIPPSDPFIPWAAAILVLNSCVNPIIYATKHPHFRDVFRLMLRCQCSTIRPKNNFVRRNVIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGY8</accession>
    <name>A0A8B7XGY8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Neurogenic locus notch homolog protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110973136</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079386.1">
        <property type="nucleotide sequence ID" value="XM_022223694.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079387.1">
        <property type="nucleotide sequence ID" value="XM_022223695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGY8"/>
    <dbReference type="GeneID" id="110973136"/>
    <dbReference type="KEGG" id="aplc:110973136"/>
    <dbReference type="OMA" id="TYRPMWT"/>
    <dbReference type="OrthoDB" id="9890094at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.20.10">
        <property type="entry name" value="Plasmodium vivax P25 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665424" evidence="7">
        <location>
            <begin position="23"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1159"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="400"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="755"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="889"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022079386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022079387.1"/>
        </source>
    </evidence>
    <sequence length="1218" mass="131556" checksum="BCDAA88CA60CD54F" modified="2022-01-19" version="1">MEALGQLCKLIFVAGLVQSAVSQVTIENCPGNIYSKTGEAEWALPTARTDSGLGVNVECDHSHQPTLYTAYTTKVVCTAKDWDGYIATCSFNIYLPDGAGCPKRPDNANDKCSCSMYRPFFYPCGCIDSYSGLTCQVLDGNKCSTSNTPSSCDCNAGPCRCHKGFKGESCELDFQVPEIICPQDIYTVQKAVVLPGNDSFTATDNDGNQVAIECSPPLGTVVTAGTGNTTVHGVTCSARDSAGNRADCSFKVVIDLVPPRIPYCPGNMHTNDFRHEWPVDMAVDNSHPTLNVTCEPAPGEELTDYVTNVNCYVHDKAGNAAEENCTFQIYLDGGSCNNGDINCECDGNSCSCADGFSGIDCTVEDGSICAFSGEPGPGCVCNGVSNCTCRDGFKGASCEIDFMPPELSNCPFGEIWSRKTMVTYRPMWTKDNNHTDVPTTVVCYPEEGSEFLAYRTDVTCSAEDASGNKELDCEFPVMRISGSGCESDGNNCYNCQSRCRCLPGYVGPNCQVCGTCENGGTREDPNQCQCQCPTLHHGLDCDECYEPNADHCMNQGTFIMDTCSCECEGDWTGRHCEQKPGEECSNLSANDSLGCSCSNEECTCKPAYSGPKCDSCKACQNGGSDQEPDSCVCNCPGFYLPPICSECDTSAVCQNGGTLDEITCTCHCASGWRGEECADEVTFEHKCPIDIIKRPDEGQTTAKVSWTGPTESGANVDCQPASGSQFPVGTTQVTCTAIYADPGTNSSSCSFKVFIDGRAPLVNCPPDLDPYHQRWKDTAQISWGGVTAEDEVSGTIAASCIPRSGSVFQPGATTVVCTAFDQAMNLGFCTFEVTVYTRGNTIRFPTTLSCAKCQENNPNGRCRYDENEDEYVCYCSSGFTTDANGKCQDIDECNEEGRCEPNAECVNTVGSYRCECSDGFFGSGTTCREYPYPMYPDISNPEADKRPLEKMFSVDVRLASESMFGCDLANDPMSDDCQILQTVFNQKLREKYTEFSPALLQIIFDQNRMRAGSFGHVAVYDYSRLSTSQRATSAQVFYDQTLASSVTDGDLGGLKLVSDCTECNPPKELTNLCGNSLEKPNCGDGFFLKEMKAEDDTSCLFVCESLCSTEFCNAGTCTHHPPYEPKCRCPSNTVGPQCEPVTVTDGGGDNGDKNTPANLTVIIACSVTGGVLLLLILAAIGYFVFRRNKNAKKDIYHEKSGHINEDFAMEKSVDSKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM47</accession>
    <name>A0A8B7XM47_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">c-Myc-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110974502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AMY1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081883.1">
        <property type="nucleotide sequence ID" value="XM_022226191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM47"/>
    <dbReference type="GeneID" id="110974502"/>
    <dbReference type="KEGG" id="aplc:110974502"/>
    <dbReference type="OMA" id="MMHYKEE"/>
    <dbReference type="OrthoDB" id="524165at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21937">
        <property type="entry name" value="ZIP_MycBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026060">
        <property type="entry name" value="AMY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000580">
        <property type="entry name" value="TSC22/Bun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168">
        <property type="entry name" value="ASSOCIATE OF C-MYC AMY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13168:SF0">
        <property type="entry name" value="C-MYC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01166">
        <property type="entry name" value="TSC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02028">
        <property type="entry name" value="CMYCBINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58026">
        <property type="entry name" value="Delta-sleep-inducing peptide immunoreactive peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022081883.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12868" checksum="4A1AB1738D764F06" modified="2022-01-19" version="1">MPQKLEELDMTTFRPADSKREEFRKYLEKAGVLDTLTKILVSLYEEPEKPNNALDFLKQHLNVAGPETADVEALRLQVSELQQKVEQLQDENKELRAKLQQENPDEGQGSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMX6</accession>
    <name>A0A8B7XMX6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pituitary homeobox x-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110974233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family. Bicoid subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081421.1">
        <property type="nucleotide sequence ID" value="XM_022225729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMX6"/>
    <dbReference type="GeneID" id="110974233"/>
    <dbReference type="KEGG" id="aplc:110974233"/>
    <dbReference type="OMA" id="NHTLSAC"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000679">
        <property type="entry name" value="Homeobox protein aristaless"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45882:SF3">
        <property type="entry name" value="PITUITARY HOMEOBOX HOMOLOG PTX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="101"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="103"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081421.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="34881" checksum="CE4FD835F3FFD58F" modified="2022-01-19" version="1">MEILSAPLSALETYAGTDALRTAGRLPRGVVEKVVSGDGGSGNHLSRHGVSSAEGSHGSAWSNRVNAGSRERSTRAETSVESAGKDSGAENSDESETGKRRRQRRQRTHFTSQQLQELEGNFARNRYPDMSTREEIAAWTNLTESRVRIWFKNRRAKWRKRERNQLNELKNGFGSQFNGLMQPFDDGLYSGYSYNNWAAKSAAAAKSFPWSLNSLGSVTSQPMCFNPPQSAVSPSFSSAPMGGVTPHQNLGPLGHQAGAAAAAAAGTAGCPHGSSPYVYRAEPGSGSLASLCLKAKQHSGGVGGFTYPVQNHTLSACQYATLNGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ70</accession>
    <name>A0A8B7XQ70_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal acetylcholine receptor subunit alpha-7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082963.1">
        <property type="nucleotide sequence ID" value="XM_022227271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ70"/>
    <dbReference type="GeneID" id="110975131"/>
    <dbReference type="KEGG" id="aplc:110975131"/>
    <dbReference type="OMA" id="FINNCIL"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="165"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082963.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34977" checksum="54E18B382D2F40C5" modified="2022-01-19" version="1">MSFDFSWRDEFLVWNPGDYNGQTELRTLRPNIWKPNLVVLENVNSNFAVHDNTEISITSNGTVNWYAPVIYQTACKVNVRQFPFDVQHCNLSFLSWTFDQSRLELWYFDDEDAKQEVFSGDGVWHLVDVAAERKDVFWACCEQPFSIVVYTLTFERSSLFYTFSILIPSVLLTTITLALFWMPAESGEKISLGMTNLLAFVLFQQLIADSMPPLGDQTPIITIYLFCMVVVGCASIYVAVYVLRLYHTPSDKPVPQGVVNVVKCLSRQKAPVTWQAVSRIIDKGMFAVFLVSSVVIMVTSFIAVKHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQK4</accession>
    <name>A0A8B7XQK4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxysteroid 11-beta-dehydrogenase 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083109.1">
        <property type="nucleotide sequence ID" value="XM_022227417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQK4"/>
    <dbReference type="GeneID" id="110975185"/>
    <dbReference type="KEGG" id="aplc:110975185"/>
    <dbReference type="OMA" id="FNGDVEH"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051253">
        <property type="entry name" value="11-beta-HSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44279">
        <property type="entry name" value="HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44279:SF2">
        <property type="entry name" value="HYDROXYSTEROID (11-BETA) DEHYDROGENASE 1-LIKE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022083109.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33424" checksum="CB311462A977E480" modified="2022-01-19" version="1">MGLKKYLIAVIAGYFGFLLIDRFDPASINGKRVVITGASTGIGEQIAYQYARLGARVLITARREAVLQQVVARCKELGAQEAFYLALDMGRENDTRRLIDEAKVRFGGLDHLILNHITNNYMALWTGDLKKLRKTMDINFHAYVSLATFATPMLAESKGSIGVVSSVAGKAGVPFVADYSASKFALHGFFDSLRQEFQMQNIGISVTMFVIGAIDTPNALEYAKEVMTTNLFLTTSSSTAYRILTGTANREREVYYPLNEILPLPLLRDSAPRLLEVFIRMTIKSEFLEEIQNNPKPFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQR8</accession>
    <name>A0A8B7XQR8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NudC domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022082345.1">
        <property type="nucleotide sequence ID" value="XM_022226653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQR8"/>
    <dbReference type="GeneID" id="110974781"/>
    <dbReference type="KEGG" id="aplc:110974781"/>
    <dbReference type="CTD" id="84955"/>
    <dbReference type="OMA" id="DTRFVHH"/>
    <dbReference type="OrthoDB" id="428655at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037895">
        <property type="entry name" value="NUDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664">
        <property type="entry name" value="CHRONIC MYELOGENOUS LEUKEMIA TUMOR ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21664:SF1">
        <property type="entry name" value="NUDC DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="7">
        <location>
            <begin position="290"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082345.1"/>
        </source>
    </evidence>
    <sequence length="604" mass="67136" checksum="FBFCD23397D148E4" modified="2022-01-19" version="1">MCTDTLQANRDLLDPHFDGYKLSLDPLPTYSIDVVCGIDEVKLRNDQYTLQHVKAFGIHNHLVHDQWNPNCVYYIDQEWKVIQHRVVLESQLQPGRVVFEISHECEQRSRPRHNATLHFPSAELCLLADGAGTLYLLATADRDCAELSTWQVLYSGEVCGPATPFVLLHSVAQADSASVHCLLLRIEEEQDRTTGDECEASTARTSGNFAALLDWLTMSKPQGASSHQVSRRRKLKSKLAPFYAAVEATGQALFLAGEAEFKITEDSAKSATEDQKQDIKEKDADISTNTTHPQYTWTQTDDDVTLVFILPPSTPKSAVNLTLTPDTMQLSVKNGDELLSGALYRAVDVQLCTWTLENRKLEVTLAKADEGPMWTEVVVGNHRGEYVIDEDQARIIHDRLAHLTSDQLNPDPVPGGSQPGIGPHDLEECDALPDGYSTLVRLDGESHTVTNRASLSSHQFLFNAQLHPDKLPCICLRHDVDGLLWQPGMGADGQRSAPWCHAATFNALGYVQASKRDRKYSCCPPGCSYAVVCDCIRHLYVYRQPAPILSPLRNRKSGRVVSQIAKQQLVSLESTDDILGVAAADDRLFVLTNNKLYVIRVDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQX8</accession>
    <name>A0A8B7XQX8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110974922</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082582.1">
        <property type="nucleotide sequence ID" value="XM_022226890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQX8"/>
    <dbReference type="GeneID" id="110974922"/>
    <dbReference type="KEGG" id="aplc:110974922"/>
    <dbReference type="OMA" id="TPNWKIL"/>
    <dbReference type="OrthoDB" id="10062319at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022082582.1"/>
        </source>
    </evidence>
    <sequence length="545" mass="61235" checksum="129AA58934A9028B" modified="2022-01-19" version="1">MAIRPSPINGGPCPKYRASPLRKPKEHPDIKVTSHKQTVQHSVRAQKLDERQLSKLFKSLDDLKIKRSLQIDKEISEQEQILENLNNAWEQRRATRGNSSRSTFADSDLSSLLPDQFKRGRRPSLQRSSSNFDLYAFMMRRASDQAVAPYNVSTIRGDKNSPKKSRSSKQLKKFPLQKSTSITLNKDRCDSGLAKAADVDVLPGKSDRIRIMSTSPVSATSLSRSMSIESPPPSTTFHELNVKDGTAPPTPQRFPSGSDWPSQVVSDVNKDASKCAQQKQQRTAHGTRGPIPNRKGREGCEGKRDLRVDAHNEARTHGSLFGKLKKEVSFHFDKEESQRDALGSTGVALGAGIMEKNNILEPSPVSSQSAISQQECKEPDCIFHNKAYRKTHYSDGDEYTIDDYYRTVGVKSAVSPLFVSASSPRSWSRRGMVRPPSPNLSDFLHDFDQGKTAKDSSKCNSAESGSKFLSVRRPLKGSNRERMLKDKEENVRTTFNLMRQKMADLKPCEFNQNYGTPTPNWKILNPLKMRHKINQSNPLHVRWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTC6</accession>
    <name>A0A8B7XTC6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UPF0696 protein C11orf68 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083265.1">
        <property type="nucleotide sequence ID" value="XM_022227573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTC6"/>
    <dbReference type="GeneID" id="110975251"/>
    <dbReference type="KEGG" id="aplc:110975251"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083265.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39884" checksum="53B20FA206B87414" modified="2022-01-19" version="1">MIVSQKNLIFPCFTQVYYKLNKGNYKQDDRMGQPWIIFDPSTENLDTFLTEKAPSKISSLDGHNWICVRHSKMNTQAADQAADLPDSNSDDDQNEELVSDEQEDGEASCLDMYTAWEELCATMRPTHEAICQFAKAQRCLVGKWLLFAETGNAVDELWSKVARAVLEGKLGISAKVSVRNDRHRSHVICIYNSDFTDVEAVRRLEKGIRSLGFCKNMTYKADLFTYLGVYAKNHYGVKPTIYSSKLDAIKRELVFQYDQRRATDNPRRHSHRRKPAKHDAMEDKSQRKMTDFFKENSSSSPGKRKHQSPSASQSQEDEPTSKLPKRIESINDPSSTALDPGAPSLPVLHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XU15</accession>
    <name>A0A8B7XU15_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110975324</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083411.1">
        <property type="nucleotide sequence ID" value="XM_022227719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XU15"/>
    <dbReference type="GeneID" id="110975324"/>
    <dbReference type="KEGG" id="aplc:110975324"/>
    <dbReference type="CTD" id="6156"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022083411.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12580" checksum="8816E9D5A1A4F646" modified="2022-01-19" version="1">MVASKKQKKQMESINSRLQLVMKSGKYHLGYKQTLKALRQGKGKLVILANNTLPLRKSEIEYYAMLAKTGVHHYTGNNIELGTACGKYFRVCTLCITDPGDSDIIRSMPSGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV04</accession>
    <name>A0A8B7XV04_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium-dependent phosphate transport protein 2A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110976049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084688.1">
        <property type="nucleotide sequence ID" value="XM_022228996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XV04"/>
    <dbReference type="GeneID" id="110976049"/>
    <dbReference type="KEGG" id="aplc:110976049"/>
    <dbReference type="OrthoDB" id="76259at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01013">
        <property type="entry name" value="2a58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037997">
        <property type="entry name" value="Na_Pi_symport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="SODIUM-DEPENDENT PHOSPHATE TRANSPORT PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022084688.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="72841" checksum="E85055FD3F35F43C" modified="2022-01-19" version="1">MASLDGQSIRLTIPVPKSPITGPPPVYAREAGPKEEIVWVSNVEPVPVSDHIPPHTPLPLETKIDFPFPAEALVGTKLGGPMTGLDATPNQMIGLMDDQLGATKANGHQEEGTEEVDVWEPPKIEHQGVKWSDLTTRGKVRRVLVEWLLKPLCILALLYLFICSLDLMSSAFRLLGGKEAGRVLSENELLNNPICGLMIGILATVLVQSSSTSTSIVVSIVAAGILEVQPAIFIIMGANIGTSVTNTIVSLTQSGNRNEFRRAFAGATIHDMFNWLSVIVLLPIEVTSHYLYHVTNAIVEAFNIQGTGGAKVELLKVLTKPFSKLVISIDSKVVSKIATGELNATDAKLLKKGNYLFRYIADAGLSERAVGGILLVVSLTMLCICLVLMVKLLHSCLKGRIANIIQKTINSNLPGPFFYLTGLLAIVVGAGVTFIVQSSSVFTSAMTPLVGLGVIRLERMYPLTLGSNIGTTATGILAALASADGKLDSSLQIALCHLFFNISGILLWYPLPFMRKVPIFLAKTLGNTTAKYRWFAIFYLVVMFFLLPLLVFGLSLVSIWLLAGVGIPFLLIVAFIIIINVLQRKKKSILPKKLQTWDSLPDWMHSLKPIDKMITKILEIVRKCCPCKKKASVSLNSSSSSGRPLMVAYNEPHNTTKTETVQALSIKSTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW85</accession>
    <name>A0A8B7XW85_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trace amine-associated receptor 7c-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975702</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084101.1">
        <property type="nucleotide sequence ID" value="XM_022228409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XW85"/>
    <dbReference type="GeneID" id="110975702"/>
    <dbReference type="KEGG" id="aplc:110975702"/>
    <dbReference type="OMA" id="CETDHIV"/>
    <dbReference type="OrthoDB" id="6376512at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="30"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022084101.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38062" checksum="BDAFCBD12C36BECC" modified="2022-01-19" version="1">MNATRGVEGSTPGKWICLLTALEGVVGFIGNLLVCFVILRVKFLHNRANYLLVNLAVADTLLCLYSVFNCLAVHENFALIRIVPTNVGGKELFCRLLASRYFSWAFSCASAYNLCVVTLERYVAIVHPLQYERKLTATRMTFLIALSWTTSFLFSTPLLFSRESSKDPDKACLEFGYPSLIYPVSVGVFLFLLSFLIPIMSMSFAYYKMQVTLKRQANALNLQHARAAAYDLVIARQRLVNMLTIVVGAQIILWTPSYINSLICLYPSDNALFAFCGSTRYIYFRGISNFAFYLNSVINPIIYEFKYKKFRQGFKIACCSCFKRRGNNRVDADLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWJ8</accession>
    <name>A0A8B7XWJ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bromodomain-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110975751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084196.1">
        <property type="nucleotide sequence ID" value="XM_022228504.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975751"/>
    <dbReference type="KEGG" id="aplc:110975751"/>
    <dbReference type="CTD" id="23476"/>
    <dbReference type="OMA" id="VAMECPT"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05497">
        <property type="entry name" value="Bromo_Brdt_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05498">
        <property type="entry name" value="Bromo_Brdt_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000003">
        <property type="entry name" value="Bromodomain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.220:FF:000001">
        <property type="entry name" value="bromodomain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000002">
        <property type="entry name" value="Bromodomain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031354">
        <property type="entry name" value="BRD4_CDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043508">
        <property type="entry name" value="Bromo_Brdt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043509">
        <property type="entry name" value="Bromo_Brdt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17105">
        <property type="entry name" value="BRD4_CDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="417"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="6">
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            <begin position="690"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="198"/>
            <end position="397"/>
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    </feature>
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    </feature>
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            <begin position="768"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="833"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1345"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
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            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
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            <begin position="336"/>
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    </feature>
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            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
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            <begin position="511"/>
            <end position="523"/>
        </location>
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        <location>
            <begin position="528"/>
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        </location>
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        <location>
            <begin position="575"/>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="616"/>
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    </feature>
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            <begin position="647"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="768"/>
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        </location>
    </feature>
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        <location>
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            <begin position="835"/>
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            <begin position="1003"/>
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        <location>
            <begin position="1051"/>
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        <location>
            <begin position="1096"/>
            <end position="1112"/>
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            <begin position="1208"/>
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            <begin position="1355"/>
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            <begin position="1367"/>
            <end position="1450"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
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        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    </evidence>
    <sequence length="1471" mass="160558" checksum="CDB0E4AA68F886D4" modified="2022-01-19" version="1">MDSKGHPTLQGYQQSVQNTVTAFHPTPVNVPEQSGHPSLDEDTTQTTTSVSQQPAQHNQSLTAMKADMPQANQTDSASQVQQLKRPAGRMTNQLQYLQKTVMKALWKHQFAWPFHAPVDPEKLSLPDYFKIIKHPMDLGTIKKKLESNSYYSAKDCISDFNLMFTNCYVYNKPGEDVVLMGQALEKLFLTKVAQMPQEEVELPPPSKVGAGDDPLTGGKKGKRGRGRGAPQRAAAATAAAAVTPSAHLAENNHTSPSTRPAAPTSRPTPNTRPTPPTTRPTPARPGPPSIPTQQQAAPIEPVLPPPPVHPGGKGQMSSPPQGVSKVRKGVKRKADTTTPSTTPSVPSALHNSFSPLDMAAAPKPNKIATRRESGRQIKPPKRELPDEEAQHQKGKKSKLSVQLRHCYGILKEMLSKKHAMYAWPFFKPVDADVLGLHDYHDIIKHPMDLGTIKEKLENRVYKNANEFAADMRMMFTNCYKYNPPDHDVVNMARKLQDVFEVRFAKMPDEPVTADEDNEDEEGKDSEASSHGSTSGSSCSDDDSEAERESQLSKLQAQLKSVHEQLTALSQASQNRAKRKKEHKKKRRKDKDGENHHAPPEKDKDHHRSGGGGVVEPVEKEGSRGEKPAKVKEEAEPKVKEEVETKAAKPKKPRAKTNKAKAGGDKATKASKTKKSSSSSKRSKAVVPAYDSEDEDMAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQSREPALKDSNPDEIEIDFENLKSSTLRELERYVMSCLRKKPRKPYASKKAQGKSKEEAVKEKKQELEKRLQAVSGQLGGGFQKKSAKKAQQEALDSLVDVGGTNRLSASSSSSSGTDSSSSSSSSSNSSDSSDSESAEQASPRKRLRPSTASPPGRKPPTPRKAVRHSLRFHPPWKKAFLYNWSPLVVAGLMKGLLDSYIHCAHANSVHANILMFSFLSMSAAQATVPSGKATSQPTVKTKAAAAAAAAAAKAAAEAAAEAAAAQAAAAAAQAIKPPPQPETPLSKPPAPVSHLSLPAQPSRPSSKAAPLPAKLQSKRPLLSPPAAAKQDAKPPLQSPPPLQPVQQMSPVVTSPPSQLLSTPAPDPAVTTQKNDVSKPSLQQQKPKVPAHQSKPAGLPTPPSLTPVKPQSTPAQPRLPKPHPRDGTVSEPPTLKAQSTTPPPQGKPQSSAQPPRHDISGAVPHGDLMNADPDTDPDHLPPEAPSQPSPPLPLGGRHESPVYSPSMPKLEKPDLVPVKFMIGDDEEEDEKEKKAEQQPMQNNSPVSTETPALPPTQSTTPKEPVKQAPPTKPSSMPSTKSSENLKKLERTAPGPLKKLPSQDVKIQNVGSWSNLATALNTAKPKQATPVVNRSTSSSFEMFRKAAQEKKERERAKKIQEEMRKSQREQAEKERQRQERERLREKEEDEALERARLAQKEDQNKQQSQKERERLREQERRKREAMAGVIDMNQQSDIMSQFEEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWT2</accession>
    <name>A0A8B7XWT2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Death ligand signal enhancer-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084495.1">
        <property type="nucleotide sequence ID" value="XM_022228803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWT2"/>
    <dbReference type="GeneID" id="110975924"/>
    <dbReference type="KEGG" id="aplc:110975924"/>
    <dbReference type="OMA" id="RHKAQAN"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052748">
        <property type="entry name" value="ISR_Activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45011:SF1">
        <property type="entry name" value="DAP3-BINDING CELL DEATH ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="436"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="486"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
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    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084495.1"/>
        </source>
    </evidence>
    <sequence length="591" mass="63718" checksum="DCC2141C10688ECA" modified="2022-01-19" version="1">MMCRLFQGIPRALRHKAQANTTHPAWTGNSSQKRRHKEETTSNGLNAAPLSSDALHPSDKRSTQPLPSGTDFNSLVRHMHLKLEDGWRSFAGSRQWDSFKEKGNSYTSHDAVEWGTALVFSLHLCRVLAASTLPDDSSGGKKKILASVADRLPGLWSKPVSLLSLLHQEEGKRTEPKPQETKPEIPDPIPATPLAAAVAGLQAVTNQSLGQAHNSLGVKKAQKGQLEEAVGHFSEGSKVGFSKATFNLAVCHEQGRGVTQDLEKAADLYKVAAAQGHPQASYNLGVFHLMGKGGLQQDMARALELMGTAAVAGVTQANRYLGIHFLEDKEQRDEGKAATFLQKAAEKQDVEAEYYLGLCYEHGWGVPSNGAKAVSLYHKAAMKDHPEALCSLARCHELGLGGLPINKKSALQFYKQASEVGHEQASESLEQLLSNPTADTSKVPQVSTRAAHNTGVIPTRESNSSNISQSRIHGLQEVNKSLHVSVSAPSLSNSEGKTLQSEPGKGSAQHKFSYKSGKASVSQLSLLLPYYFSLPSRPPIASLGMTNGAQSSKVSFQVGDEESSDEEDRADSSAHGFESRFFTSNPCLMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXA2</accession>
    <name>A0A8B7XXA2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022085509.1">
        <property type="nucleotide sequence ID" value="XM_022229817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXA2"/>
    <dbReference type="GeneID" id="110976496"/>
    <dbReference type="KEGG" id="aplc:110976496"/>
    <dbReference type="OMA" id="FCVATET"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034840950" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="247"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085509.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="57596" checksum="81C99CC0B5CD1DEB" modified="2022-01-19" version="1">MGYLRFLGVWWLVFCVATETSEDPPVVTTSQGRIVGTRLEFSPTDPALRRRVDAYLGIPYAEAPVGPLRFKPPVAKSWSGELQATKLGNRCPQPLVPFGNYTMTGPFDEDCLFLDVFVPQPVPPGAAVLVYIHGGGYLVGTGVMAQLSPIPTAAVGDVIVVTLNYRLGSFGFLSTNDDVIPGNMGLLDQRLALAWVRDNIQAFGGDPARVAIFGLSAGAASVGLHMVSPGSEGLFRGAILELLEKFGRGQLLPFAPVVDGAVIPADPDDLHERGAINDAVSIIGAFAYDGMFEIQNDFPSNTDEAPFVDSDTYDAKAKFHLALAVSPEPIVADAAKMMYADPSCADTPDCDYLQSLSQAIGDAMFVCPGVKTAKAFTKAGRKVYHYHMSHVPTTPMLGNKWTKATHGDDLIFVFGLPLIPSANWSFTEDEARMSIQTIKYWSNLAKTGNPNLSAMDDEQGEEATLPEWPLFTLEELAYKDLSPSMGNGRGIKAKECLMWNEFIPKVIQTTEAKKCYGKRRRGDKLRRKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY62</accession>
    <name>A0A8B7XY62_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC110976663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110976663</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085829.1">
        <property type="nucleotide sequence ID" value="XM_022230137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XY62"/>
    <dbReference type="GeneID" id="110976663"/>
    <dbReference type="KEGG" id="aplc:110976663"/>
    <dbReference type="OMA" id="MHRDERP"/>
    <dbReference type="OrthoDB" id="3565419at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF104">
        <property type="entry name" value="AT-RICH BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="786"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="815"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="843"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="872"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="928"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="437"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="945"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="530"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="654"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="947"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022085829.1"/>
        </source>
    </evidence>
    <sequence length="1101" mass="124331" checksum="C37A05DEE3FF5750" modified="2022-01-19" version="1">MDDPDISVSLVKIDSTTQGVKSAESEIANNDLVDGNLLGGSKECHMLWDSLRKQGQLFKVLDTLTAKTARLIGRVQNQTATEADSATVVELLLQLGIMFVDMETKEDGSKEKRFTFVTDVESTLTRQAFSASQSMTKAAPPQPVPPLHLSSVETGSDSDEDHADTFEPNEMTDDIVEDVPAEPPSYVCEWCKADQGTPVMLDLHLLQHCPVLTRYRDENLPCPSCGKSFRQLLRLQNHLFIEHGMETAEAVTIMHELNIKYSKQQKEDEKENEEGEALSAEESDNSTGSDATDAPPRVCIRCEVCRGKFKTRIALRSHLMEVHKFSRQKAASSVYASVRCAEVPSPTKADSHVPKKSPKQPGYLLACVKCTVSYKDRAQLVKHLKSAHFMSQNRAQKEANKKYKELNATFACDLCLKRYCNRYVFTRHLIESHQFSKNQARLKSAQMYPHDKKRRTTGATATPAARSRKLKELQLKSKDEDSDIEEGASEKQPRRSLRTARKRGRKGRTPKCISRKLAEEEAEEMSEDVQENHGNRESDDEVIPEKESSVSNSGGKTDGADEDFELEEKRAHFKKQTRKKARRSSGSISDDEDYVPSNSESEENVKKFKWGHSEKAKAKVEPTSAPPSESNVKDSEKPEENPDDDGSNRSEKLPKKRSGRGRRANVQGKHKCPHCDKSFLHLSYAKLHISTIHKEKPAYQCSTCQKPFYFKTTFLRHLNCHKNEEMGINFDCEVCGKRFLDKNALNSHKRTHSKDNPFKCEFCDKSFFHQSLLLRHRNMHTKETEYKCPHCDRVFYRKGGLTYHIASIHDKKRDHVCGQCGQGFPCKSALLAHEHSHSTARTFQCDICGTRVKTKGNLKEHMICVHTDKRAYKCEICQKTFNRSHRLTLHMMMHRDERPHKCHLCEKGFRTRTNLRVHIKWHQDQRDFQCEQCGKTFLIPGNLDRHMKTHRNGKSYRRKASRKTAPEAGLPSADQTQLTTHMEAQACTTVDNQFQTVQSLVSGEGFESDLPTLASIAQHLSTMNIPVFQATSSTTQATIPVSINRAENTCTLLPGSVMSGEASAALAAFSHAQQQLQGTGTDPPVVSQAVQGSYEHMELTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYB7</accession>
    <name>A0A8B7XYB7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110976090</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084771.1">
        <property type="nucleotide sequence ID" value="XM_022229079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYB7"/>
    <dbReference type="GeneID" id="110976090"/>
    <dbReference type="KEGG" id="aplc:110976090"/>
    <dbReference type="OMA" id="NAHERAY"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040535">
        <property type="entry name" value="NLRC4_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17889">
        <property type="entry name" value="NLRC4_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="194"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022084771.1"/>
        </source>
    </evidence>
    <sequence length="1088" mass="122474" checksum="273E6591AE260CD8" modified="2022-01-19" version="1">MAGHDGKQVSGGGRCDNALWRLAGELGQSWKPVGRHLGYSEAGIENLVQDYSANAHERAYQMLLGWKNTTDPSVRNEQLRGAVKDAERLDLLPSVMNVTGCGPSPGGVSGSAELNKQYFVKKLKNFVRSKMSKLPLVPWITTGCVHVDQVFTQVQLLISIMSAYFPIRVPLKSHNAIFTDLTGEGDTRIDFCGTRILMRGRTGSGKTTLLTKYAYDWSTDKPEALLRNVDVVLVLPMRKVDQHSNLGQAVLDHMLPNERRITPAAIEQYCEDHPEEVVILLDGYDEFKGKGLDQEDCGNIVKMLRGEWLTECRVVVTTRPGRVGDFKDDYESYRHLEITGFTTKDIDDYVHKVFEGENKLLGNKLLAYLEENHLKEDLASIPLMLTAFCQLTKWTDGQDFKDLNTISKLFDRLIECMFKHANMKISTDCSVSRATAVGLADPDQLVLELGKVALEGFLGGISEELIFSEEDFTRCSDNVQVIEQGLRVGFLSRDVDSRIRPQKFEELQLEGQKPSPRRDISFILKSIQEKCAGKYLAHLLETGDEDSFTNYLQKVDNDQRVLDYTNILVFASASNIEAARRIVSHVILMLRSTQNENISQYLTAKLHFKHCQKTQRLIETCLQLNFESNSKGQFNHLFDSLFGDNCCVRLVGISTYVAKALGYLFRHGYQRLTPQEASGDYGPPEVKQALSVKSLQLICIKLEISNQFREFLNCYPGTEEEISNFMRDSLKSEGQTNISKILHQLETSEQKIPSYFGHRSDLTFSAVFPIWQELNKHQVQDFSLSFVLSGLKESSLDELVLNGVTAECPDWSVLFKMIHDGLFAQMTKLTLSLNGLTFQQTAELAAVLVATPNLKELKISGNELGEGFVENLPELPELTSVVLDNLNLSSGAMIEFTKKMKQYPHLQKLDLRWNENIDDDVIHSICGSLLCQQTWKELRLSLYRVSEAGLDNFQRSIGLAKELTHLNLVHSPIPDKVIQYCAPALSGLKQLVDLRISGIPSSTSQEGSPCTEQTVEAFTSEMHKLQHLKFLSILYTKMEPEAFICMLNSCRKHPSLKTFRFSRVCLPLGSDVGAACKEAETTFLRLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYJ8</accession>
    <name>A0A8B7XYJ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110976288</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110976288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085110.1">
        <property type="nucleotide sequence ID" value="XM_022229418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYJ8"/>
    <dbReference type="GeneID" id="110976288"/>
    <dbReference type="KEGG" id="aplc:110976288"/>
    <dbReference type="OrthoDB" id="10041060at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="4">
        <location>
            <begin position="278"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022085110.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36347" checksum="011AA3B2DC768E09" modified="2022-01-19" version="1">MYIRMYKSLYQSIYTNMSRIISVLFLFYVGKTKMNSDALFLPGRTGHTLTKLPGSNKALLFGGICMGKSKDHFASRFCKSCKDGRFYILNTDTYEWQYLKVPLITARTYHSTSVLESDSNLTVAVIGGVVFEETLPSHREALNEIVLLTMDKELSNCTLQEISLACTTPNTPDVFLSSHATIVHNNSIIVVGGIQTHTRQISDKAPTPLPTAYRISLSSKDYDAFQKTTSAAAIFGTYGHSLHKLKCENTLLVVGGSSRQISVLTDRSFEPEPCEFVPCTIASSPMFKDPTWIQCDKCKKWYHTHCIELATVPEGHYFCLGCKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZH6</accession>
    <name>A0A8B7XZH6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110976912 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086309.1">
        <property type="nucleotide sequence ID" value="XM_022230617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZH6"/>
    <dbReference type="GeneID" id="110976912"/>
    <dbReference type="KEGG" id="aplc:110976912"/>
    <dbReference type="OrthoDB" id="2433005at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086309.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="49280" checksum="3AAEF2BEADC1FBBB" modified="2022-01-19" version="1">MSATTFCPGFSAHNPIEHVWGVLTTAATSVYLPDALPDELPPTQQHLTGQALKEQEGQVFDAALETLEGYWKGLTHSKVPIKVSHRKSKDRPSPYTNEDYDQAHQFLTWPYGDIKNAENFLDDMKFFKTHLNCRVGMVIFTKCPPTDPCQHSADRPSRNPEAVAFYQNFLSPTPSQLNPDHFLTFLEAIKATLGSPDEYMPDVQEKAPGSCNLCKFTFTSETNRKDLRRMIHLRERVHKKLYMAGILVVAGDGGAAFGERTVGDGVDAGDGGTAVGERTVNGGVDAGDGGAAVGERTVGGGVDAGDGGTAVGERTAGDGVDAGDGGTAVGERTVGDGGAAIGERTVGGGVDAGDGGAAVGERTAGDGVDAGDGGTAVGERTVGGGVDAGDGGTAVGERTAGDGVDAGDGGTAVGERTVNGGVDAGDGGAAVGERTAGDGGAVGDVGAAQQNQIGKMFLRNKSAVRLHPCWSCRCAVVGGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZN3</accession>
    <name>A0A8B7XZN3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Ribonuclease III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19 20">protein Drosha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC110976340</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022085216.1">
        <property type="nucleotide sequence ID" value="XM_022229524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZN3"/>
    <dbReference type="GeneID" id="110976340"/>
    <dbReference type="KEGG" id="aplc:110976340"/>
    <dbReference type="OMA" id="QLMATEY"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19877">
        <property type="entry name" value="DSRM_RNAse_III_meta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000002">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000012">
        <property type="entry name" value="Drosha ribonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058938">
        <property type="entry name" value="Helical_CED_Drosha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044442">
        <property type="entry name" value="RNAse_III_DSRM__animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26050">
        <property type="entry name" value="Helical_CED_Drosha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="15 21" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="300"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="24">
        <location>
            <begin position="531"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="23">
        <location>
            <begin position="686"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022085216.1"/>
        </source>
    </evidence>
    <sequence length="793" mass="92329" checksum="8ABE378EFBE48929" modified="2022-01-19" version="1">MAPSTNFLTHQPTVIEYDDREYIFEGFSLFSHCKLDNIPPCKVVRFNIEYSIIFMEEPMPENFSVKGLDLFGDFLFFEILELYDFELVSKVGGCRFFHFMPRFARQLPSNGKEILSMHHVIQHLLQMSRPVVEAKDLNYWLECNQLTWERYAEELKGMIVTCPGKKPSSVRVDQVDREVEQKPDDTKDIKDKYPTIVHFGLRPAQLSYAGNKDYQNLFKSYLKMNHLLANKPKVSLQDRQKLAEKEKKLQRMRLQGHMTREVTAEICCKDMLMTGIGSDVCQHAMMLPVLVNHIRYFNCLYNIDDIIGYKFKDRVLLKHAMTHPSYRLTYGMNPDHVRNSLYNCGIRQPDYGDKKKQVERSRKKGINTLIKIMSEMATPEELSSHIHHYERLEFLGDAVVEFVTSTHLYYLFPHLEEGGLATYRQAIVQNQHLAVLAKKLELERFLLYAHGPDLCRSSDLKHALANCLEALMGALYLEGGIPVVRRIFCELLFDLEKLRRIWMQHPKHPLQLEFPQGDRHMIQYSNILQMLQKFEESTGIKFKHIRLLARAFTQRTMSYTNLTRGHNQRMEFLGDTVLQLITSSYLYKHFPNHHEGHLSLLRSSLVNNKTQATVASDLGMSAYIIDAKNRTLEDGGPLPTKLLADLLEAFVGAMYVDQGIEAVTVFCKVCFFPRLKDFIYSQHWNDAKSQLQQCCLTLRTEGKEPDVPQYKVISQHGPTNNRVYNVAVYFRDKRLGTGCASNTQDAQMEAAKDALHNYNFPQLHHQRMVVERKYKQDGKSKERDYHRRIRDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1L9</accession>
    <name>A0A8B7Y1L9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MORN repeat-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110976673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Assembles a suppression complex (suppresome) by tethering SIRT1 and MDM2 to regulate composite modifications of p53/TP53. Confers both deacetylation-mediated functional inactivation, by SIRT1, and ubiquitination-dependent degradation, by MDM2, of p53/TP53, promoting a proliferative and cell survival behaviors. May play a role in the regulation of spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Acrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085851.1">
        <property type="nucleotide sequence ID" value="XM_022230159.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085852.1">
        <property type="nucleotide sequence ID" value="XM_022230160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1L9"/>
    <dbReference type="GeneID" id="110976673"/>
    <dbReference type="KEGG" id="aplc:110976673"/>
    <dbReference type="CTD" id="283385"/>
    <dbReference type="OMA" id="GHGRFFH"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052472">
        <property type="entry name" value="MORN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46511">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46511:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022085852.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="27477" checksum="ACA93D681B068CD8" modified="2022-01-19" version="1">MPYKKVPKKKQPLWKDWDYKAQKKGVRNTVYSVNGDEYTGEWLDNKKHGKGTQRWKKTGAIYDGDWKCGKRNGFGTLSLPSAEGGFIRVYSGGWKNDKRHGYGTNFYSAEEYYEGEWYGDKRSGWGRMYFKDDSIYEGEWYNDQRSGQGMLRLADENRYEGSWKTDKKNGPGKFFYLDKGQVYEGVWVDDIPKCGTVVDFGREGAPDPTQYPIPEVTLYDPAGVLQEAENMFLQEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y268</accession>
    <name>A0A8B7Y268_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase TRIM71-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110976963</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086395.1">
        <property type="nucleotide sequence ID" value="XM_022230703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y268"/>
    <dbReference type="GeneID" id="110976963"/>
    <dbReference type="KEGG" id="aplc:110976963"/>
    <dbReference type="OMA" id="CYHEEDR"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="101"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="8">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="255"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022086395.1"/>
        </source>
    </evidence>
    <sequence length="618" mass="70249" checksum="EEA52A7CAA141F56" modified="2022-01-19" version="1">MAASRRATFPKKFRERQLECSICCNRFTEPKFLDCLHTFCLKCLHHLELGKNPQILKIKCPLCGRNTMLESSTLEDLPTNVTLSALVEEFAILEQLLQGQGSEIKCQNCNNENPADSFCMDCAHFLCQDCRKAHGRQKRSKSHKTYTMAQLQSGEIAYKSKLREEPKCQQHPDQSRNIYCETCEQLACTACSVLKHEKHSRADVSEALKTCQQEITEFLKNTEKKKTELKNATTKTAESRKKLDTMFEATNRKISQKADKEVARIREREQKLKKEAKEIYQDRVKTLQTAEDAINNELTAAEQTQDMMKQLLAQEIKTEILHLKQKFLRSLREFVEQQQIVPEKVHFMAFQECGETEKTLGRLILKDEWKLKQTKTEGVINSVAVFSDNEIVTVDGGYEQLITYLPKTNPQTSFISQMPHITDIKDPVKVVVNRLDHLIVLDGPAVKTFSREYQLLHQFQPGTDSDSQPTCLAVDEDNLIAVGYMAKEMISLHNPDGTLIRKLTAPMIEDQLVLSNKRIVYTNCDMCKLVSEDYNGGMAFTKDIKSPLSVCCDGQGNIYVAKGLDSWQSESNIHVFGSDGRHNGCVIAHSMPPEGMMFMPAGDLLLGGKDFLHVYQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y279</accession>
    <name>A0A8B7Y279_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Prominin-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110977111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prominin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086632.1">
        <property type="nucleotide sequence ID" value="XM_022230940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y279"/>
    <dbReference type="GeneID" id="110977111"/>
    <dbReference type="KEGG" id="aplc:110977111"/>
    <dbReference type="OrthoDB" id="10065208at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071914">
        <property type="term" value="C:prominosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008795">
        <property type="entry name" value="Prominin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730">
        <property type="entry name" value="PROMININ PROM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22730:SF1">
        <property type="entry name" value="PROMININ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05478">
        <property type="entry name" value="Prominin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034280346" evidence="8">
        <location>
            <begin position="27"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="829"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022086632.1"/>
        </source>
    </evidence>
    <sequence length="876" mass="94255" checksum="EFD1260737C77DC9" modified="2022-01-19" version="1">MAKPPGGSHFLCILVTTAVIISSSAAQDEASAGHGEPSSALPGRARTASGLVSRWVLFGGELSENLGWLLSSYADLAREFVYKITPKGFPWDPLIDVFVGSPEVIQALWEIVKSEAGIFGVSLVFLLLGLLLPISGVFFCLCRCCGQCGAVRREERIRKLACCTGVIMGTFLVVFSLLVVAASCFTILSGERLSQSVMHFEGKVNSIMDDIDNFQDKLLGDLRQVGNISYIIHNTMQSLEDANNAIFGPVATEFESISVLLNSTVLQLNQDLGPPLTSLSAITGSLGGTIGQLKTDGLAFQTVVNDVASELQNFRDSDCSGSVPDTVGGVCTFIPDHSPFAGSLSYSMLNAYDVTPIVMYTAIPGPALTGISDLLLTGDSALREAQAAVSYATDDVFQDIGDTLATIQTTVTATTDEVVSGLEESLGESLDTQVFRDQVGEYVDLVEEYDMYSYVAFMVFASLGFVMSLLCLLGVLCGGCAHDKTRRPSERTKISECGGKFMMGSTWWTFVFAFLFCLPTAVWFIVGANVTLICDAMNDLTIMDKLVDNPLLWNGSTLLDSVVRFGNSPLNLTARHFLEDCQEDQAIYEALHLSSVGLLDGIDAVDISEFMPYVDAFRQNMSSTINSLDLLTGPTPLTLLVSALSVPAFPLVSMVHSVGTLKGLTEAVPGQGAIDALNLFINKTWEAYDAHGASQPDFQQQVDNANSILTDLESLVTMQADLLALLNTYTSEVTSFEASFYEVKNLTLDALPSIASGSQDLLDLSSDATNLIETSLNSYIDDLVVSAEELVTGPINKIENEVGRCGVVAEAYEATVAEVCVHFLTGFNALWLSTGIISLCCLPIIVLNVRLSKYVRRARPTEGARYRDGRPATRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5S3</accession>
    <name>A0A8B7Y5S3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110978118 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110978118</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088543.1">
        <property type="nucleotide sequence ID" value="XM_022232851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5S3"/>
    <dbReference type="GeneID" id="110978118"/>
    <dbReference type="KEGG" id="aplc:110978118"/>
    <dbReference type="OMA" id="GVSEWYR"/>
    <dbReference type="OrthoDB" id="6508643at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009913">
        <property type="term" value="P:epidermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000112">
        <property type="entry name" value="Mds1 and evi1 complex locus protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000452">
        <property type="entry name" value="Transcription factor Ovo-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027756">
        <property type="entry name" value="Ovo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032:SF271">
        <property type="entry name" value="RH12261P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10032">
        <property type="entry name" value="ZINC FINGER PROTEIN WITH KRAB AND SCAN DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="927"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="955"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="983"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1022"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="742"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="846"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="848"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022088543.1"/>
        </source>
    </evidence>
    <sequence length="1119" mass="120637" checksum="C56AE6223F0C24CC" modified="2022-01-19" version="1">MPASSTATLSPPSNNPAATGPCWDGPGPSSRDPESPASSGMPDLDRMNIVKGIHKHNERLDRAQHTTPSKGDPPCHRLQPCGAPSSGLELLTGVSEWYRLHWQNGAGSSRGGFKGREGRPTPNLPGLESFCRPWMQDSRGVQGSISPRENVSAFPLQPAPLSRQEAPDLTATPRVSSPPGNCQSSTWNKEDVLGGVDSSSSGHSKENTIAGTYPLHPASADHRAPRSPEKSRPWKSHQIQSRFEVTEGAPSLWHGDIQRQASSSDEDTLDTNTGKKCKRDVTRGEVGGHCSHDTGVQTRRPISLVVKINKKDLRITNSDDRPTSLSSFNSATKNTCASSTLGQNVESSNGALKGKASPTSHLNSRAFINSALSNIAFVNSSLSATNTSARMQDLSGNAETFMEARNVTISKDRDMRTGAARRLPTGNDKTENDQPNNDQKHQRQNGAGIARLPTGGNSGAHGLASIPTEHLPPRKRHKRASISLSLATNGNPSCGEHPANSESASEGSRAIPIRGGRNVSEKLVQPSPEASPRPVEKPCKNDESQRSQSGESDSSVVRSGREFAGNGAGGGDSPQVCREGEKCAEMAPETTAQSGRVPSTDLSEETSELSPFTPTPSSSSRATPDVAASLSNQPQSTQCEQYTHLFMHGGMVDTRPFDQELPQPPPIYGHLPAPSYTAKGPINDTPPPIGPLAPPLDLYQHPQPFPLPPYPHHRFVYDPRLTMMPPPTYTTNSLMTPYPCHGDVSSQHGGAHTHPSRGGAYSPLPYQHTHPVGHPLEAYPMSRVHPPQCYAFSPYTSPPLPPSNPSQSGDGLLQPLTTVPCPALHHSTYTAPVHHPSPYTLPVNSAVAASQPTPTTADTTLTTDSAMNQPQPPQPRNRAMNPPSTQAPVPSRPGQPETHFAPLKRAPGRSRNSNHLSSGVTLGETSFLCEVCNKVFPLQRLLNRHMKCHSATKRYNCAFCSKGFNDTFDLKRHVRTHTGVRPYKCEHCSKAFTQRCSLESHLSKVHRLLHDYNFKQRRSKVFVCEECGATTEQAEEHYAHIRDAHPNSAELLKFQDKLQFQKLLRRGEGATSPDDVGQPDRVSLAEPPTTCGSSAPPGPTTSSVVAENGMPDTTPVKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5U4</accession>
    <name>A0A8B7Y5U4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21 22 23">A disintegrin and metalloproteinase with thrombospondin motifs 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21 22 23 24 25 26 27" type="primary">LOC110977693</name>
    </gene>
    <organism evidence="20 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22 23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087716.1">
        <property type="nucleotide sequence ID" value="XM_022232024.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087717.1">
        <property type="nucleotide sequence ID" value="XM_022232025.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087719.1">
        <property type="nucleotide sequence ID" value="XM_022232027.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087720.1">
        <property type="nucleotide sequence ID" value="XM_022232028.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087721.1">
        <property type="nucleotide sequence ID" value="XM_022232029.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087722.1">
        <property type="nucleotide sequence ID" value="XM_022232030.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087723.1">
        <property type="nucleotide sequence ID" value="XM_022232031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5U4"/>
    <dbReference type="GeneID" id="110977693"/>
    <dbReference type="KEGG" id="aplc:110977693"/>
    <dbReference type="OMA" id="GPEWRHD"/>
    <dbReference type="OrthoDB" id="10035764at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04273">
        <property type="entry name" value="ZnMc_ADAMTS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000006">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF311">
        <property type="entry name" value="ADAM CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9 14 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="18">
        <location>
            <begin position="268"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="19">
        <location>
            <begin position="1097"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 16">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="343"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="380"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="399"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="521"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="585"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="589"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="600"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022087716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022087717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022087719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022087720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022087721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022087722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022087723.1"/>
        </source>
    </evidence>
    <sequence length="1135" mass="127934" checksum="224665B2309280D8" modified="2022-01-19" version="1">MGKYIVWILVAWMFSLLAVVYIKRILVDPGLNFREDARFSRLRSQHQIVIPALVDENGNHVSYDIINSRKRTRRDVPSGPQNASDIRQLHYKLSAYGSEFHLNLTLNTNLVTRNFVVEYLDEHGVGSTHRTVDDCHYHGHVAGHDISSVAISNCKGLHGLISTAEADYFLEPIHDLSRNSFEGHPHIIYKRESDTKYRFQEDGDCGVTDSDEVKKTWWMTNSDFSFAEQVMKKHHHHQTRHQTHHHHHHQHHKRTRRRREVSSTSSELNVETLVVADKLMNSYHEDYIESYLLTLMNIVADLYHDASVGNNINIVISRIILVLQDQKDLTLGHHADMSLQSFCQWQRNLRPPENISASGEDSGNIHKHDNAVLITRYDICMLSNRPCGTIGLAPVGVMCNPGQSCNINEDTGLATAFTIAHEIGHNFGMKHDGDGNACGTRGGIMADQITENTDPFVWSACSMEYIRNYIDSGKANCLDNAPELVSYSYPTAMPGQLVDGDHQCRLQYGPEVKACKTNSICRELTCLKPGSRSCWRTNTPAAEGTRCQTPSTPVGWCYGGDCVPYGEKPQAVDGGWGAWSEWSSCSRTCGGGVTVSERQCDNPRPSHRGLYCIGERSLYKSCNIDECPVNSRDFRSVQCSNFNNEPYSGRYYFWEPYTISDMGPCELTCITSGGEHFRKVNKIVDGTRCFPEKMKPEVLDICINKKCHPVGCDKILGSDVREDKCRICGGDGSTCETVSKNFTKSLSAGDYHEIFTIPRGSVHIRIEEMTASRNYLALKSVNNDYYLNAEWIIDWPKAYDVSGTTFKYERPDQGVESLTALGPINEELVVMLLVQEDQQGISYSYNQPVTRQGSGDDEVVFIWHWSSWSVCSSTCAGGESIAEVQCIRYDDKTVVSDTFCNPGTKPSRRKQSCNTEPCPPVWSEGPWSECSQTCGGGRKTRTVLCMTKVTQLEEEVVDESQCTKRKPIDRMNCSMQECPPQWVAEAWSQCVPSCGQGHQTRRVTCMTSKGEPYPNMCNWATRPSAIRECQTAGCPPPRWVTGEWSECNARCGRGQQQRQVRCLSYNNVPLRSTYCKQSPKPNTQQQCESPCVSKPTEEDECQDAPSVQYCPLVVKYKFCNNEYFRKMCCQSCSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5X0</accession>
    <name>A0A8B7Y5X0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger SWIM domain-containing protein 6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110977419</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087221.1">
        <property type="nucleotide sequence ID" value="XM_022231529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5X0"/>
    <dbReference type="GeneID" id="110977419"/>
    <dbReference type="KEGG" id="aplc:110977419"/>
    <dbReference type="OrthoDB" id="10013584at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048370">
        <property type="entry name" value="ZSWIM4-8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN CONTAINING PROTEIN 4, 5, 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22619:SF0">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21055">
        <property type="entry name" value="ZSWIM4-8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022087221.1"/>
        </source>
    </evidence>
    <sequence length="1059" mass="118930" checksum="F67AE57D39A19719" modified="2022-01-19" version="1">MRIVFWSFPRNEKDICMYSSLHHSTVSESEYQKLPFQRGVRLLDNNAVDHVLQVGFHLSGTVTEPGNQLYNEPEQVHRVSISFDRCKITAVTCTCGNRDIFWCQHVVALSLYRIRQAGSVQLRLPISETLLQMDREQLQKFAQYLITAHHTNVLPTAQQLADEILQSKSRINQLPGAPDPTAGASIDDDSCWHLDTEQVQEQVKLYLQQGGYYDSEKQLNSLFAKVREMLRVRDSNGARMLTLITEQFMVDPRLQLWKQQGTPMTDKHRQLWDQLGLLWMVVVMNPGYTQREKMTWKEQLLQWGSNDLCPLEDADARNNLTNPSLVGVLNNPPAASDADRPRTIFTRAIEACDLQWNDSHLQGILNNKLYHSIHHADTEFGGFDSEGHPLWSEHLPTACARVDALRSHGYPKDALRLAVSIVRNLKKQQRDSLKQLRPSGRKGKHRKASQNAASSNESSHTARSSTEAWVGHPLDPIGCLMDTLLDASLTVDSSTSGAESSNADIAGSSSPLRQYRHVAIPGSRSQQQQQPETYLTLAYEVVLVGLGQQRLMPTGLYAQDKACHAEEELIARHREIAMDPMLVAVLQRQATTLMEGGPSSGLSYHVPAESVPMHTFGRYLFQTLLPYYEDLAYKVGLRAMRLPILAEVSSNPGSAANSVLMGRYPRWFVLGHIEAQQCELASCMMTAAKDDVCRLRTVLEAAQHHIHSASQLFKLAQEAFKVATPVDGPTHYTLLKATFDLGLHIMRMTLSNMNWRRREMVRWMVTCATEIGVSALITIMQSWYSFFSPTEATTMVATTIMAPNTAVRLNLSLTQQEELARYARSVALQCASKDPPSCALCALTLCEKDHVTFKAAYQIVVDAASGPMNSSQLFIIARYMEHRGYASHAYNLAVLAMRNLTLGYNQDTHPSINDVYWACALSHSLGREQLSNMIPLVVKSVQCASVLADVLHRCTLTAPGVGCLPDGKRRCIKLLPHDKDPMRQLLDAAIAAYVNTAHSRLTHISPRHYGDFIEFLSKARETFLLAPDGHIRFAKLIEDLKVMYRGKKKLMHLVRERFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6H4</accession>
    <name>A0A8B7Y6H4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LOW QUALITY PROTEIN: testis-specific serine/threonine-protein kinase 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110977929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088157.1">
        <property type="nucleotide sequence ID" value="XM_022232465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977929"/>
    <dbReference type="KEGG" id="aplc:110977929"/>
    <dbReference type="OMA" id="VYHYLIM"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF74">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="12"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022088157.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="31478" checksum="2088DDE040494E0E" modified="2022-01-19" version="1">MGHTTLKEEYEVDKGAIIGRGRFSTVKLAFCRRHGRHVAAKIIPLSRENEDALSMASREFVIMSRLVHGNIIDVYDHFVEAGSLWIIMEHAQNGDLRKFVHLRRRLSERLARKFFAQILDAVAYMHSQDIVHRDIKCXNIVVTGNEEVVKICDFGCAVSRTEHTGSDPPSQHRDGFYGSPAYAAPEVLDRAGGELKPADVWSTGVVLFFMVCGYLPFGCDDVARIRTRMTSAPLRWPRPLRQIDRTCRDYAESILKVRPENRPTAADALRAKWMEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y777</accession>
    <name>A0A8B7Y777_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cholesterol 7-desaturase</fullName>
            <ecNumber evidence="14">1.14.19.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110977954</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:51644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:45024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45025"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid hormone biosynthesis; dafachronic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cholesterol 7-desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.21" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022088195.1">
        <property type="nucleotide sequence ID" value="XM_022232503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y777"/>
    <dbReference type="GeneID" id="110977954"/>
    <dbReference type="KEGG" id="aplc:110977954"/>
    <dbReference type="OMA" id="RHAINEM"/>
    <dbReference type="OrthoDB" id="6428779at2759"/>
    <dbReference type="UniPathway" id="UPA01020"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170056">
        <property type="term" value="F:cholesterol 7-desaturase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="18">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022088195.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35813" checksum="AC3495192D5C3427" modified="2022-01-19" version="1">MKRSRKIGDMPPVYPNGLNLAVFRGESGRAYIVDAYCPHLGANLAVGGKVTGECIECPFHGWTYQGEDGKCVKIGYAEKVPDFVKVPTYRSLEINNLILLWYHAEGEEPSWYPPEVEKIKSGELMLDGTWEVYLDCHIQDVVENGGDATHLDYVHGPQIFPKNFINVKWEVHSTKKHVSISDSQTLPFYSSKPFVRNIQEQYGPGLSYVFGNEFLLVGAVPVGPLRQKIVFSQYSRSTSVFGIFRRLFMKLLLYWTYVVIKGDVFIWANKTYKKTPQLVKEDKFLLGHRRWFSQFYTEHSPRYNPPDPLQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAU9</accession>
    <name>A0A8B7YAU9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Cation-transporting ATPase</fullName>
            <ecNumber evidence="24">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC110979125</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine. Also stimulates cellular uptake of polyamines and protects against polyamine toxicity. Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Contributes to cellular zinc homeostasis. Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress. Required for proper lysosomal and mitochondrial maintenance. Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels. Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Promotes secretion of exosomes as well as secretion of SCNA via exosomes. Plays a role in lipid homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>spermidine(out) + ATP + H2O = spermidine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>spermine(out) + ATP + H2O = spermine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45725"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="23">Interacts with MYCBP2; the interaction inhibits the ubiquitination of TSC2 by MYCBP2. Interacts with HDAC6; the interaction results in recruitment of HDAC6 to lysosomes to promote CTTN deacetylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Endosome</location>
            <location evidence="22">Multivesicular body membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="24">Membrane</location>
            <topology evidence="24">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="24"/>
    <dbReference type="RefSeq" id="XP_022090369.1">
        <property type="nucleotide sequence ID" value="XM_022234677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAU9"/>
    <dbReference type="GeneID" id="110979125"/>
    <dbReference type="KEGG" id="aplc:110979125"/>
    <dbReference type="OMA" id="VWISDEY"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903543">
        <property type="term" value="P:positive regulation of exosomal secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905165">
        <property type="term" value="P:regulation of lysosomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010821">
        <property type="term" value="P:regulation of mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900180">
        <property type="term" value="P:regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000023">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000060">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000026">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000045">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12 24" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 24" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="899"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="923"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="960"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1005"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1040"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1080"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="27">
        <location>
            <begin position="19"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="26">
        <location>
            <begin position="156"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="25">
        <location>
            <begin position="249"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00053898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00065284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022090369.1"/>
        </source>
    </evidence>
    <sequence length="1137" mass="127229" checksum="778E4EF60165E51B" modified="2022-01-19" version="1">MKKRSSDKQPGLEIQEGKDDAFVCYGYHRSKAWTWLSYTLCVCTVGLAALVFYWKPDWWIKFTCWVCDLREADKIIIKDIYQRYHVCQIRTMEVNSKSVCGPSSLKKLLHRDVVIDGVLKYLKFQKVRYMWDPKEETFFKLRVLDGANSCSEFYDMLQNGLTEKEANKRRFLYGYNKISIRVRPIIILLIQEVLNPFYIFQLFSIGVWISDEYYYYCGCIFLMSAVSITVALYTTRKQSITLRDMVESNTTVEVLRKSGDCIKVPEDLLVPGDVMVLPPEGCVMTCDAVLLTGNCIVNESMLTGESVPVTKTPLPCVSGSDGEEDSGYNADKHKRHTLYCGTHIIQTRYYGGEMVKAVVVRTGFSTAKGNLVRSILYPKPMDFSMLKDALLFLCALSTFAVIGFTYGIIIFVQSGYDGGYIARRALDVITIAVPPALPASLTIGMLFAQLRLKSKGIFCISPQRINTCGSLNVVCFDKTGTLTEDGLDLMGVQLAGSGTFGELKTSVADDTTEHHLAAMATCHSLTIINGELSGDPIDLKMFQATGWDLEEPTSKESTNFDILVPTIVRSPFKADEREIGVLRQFPFSSDLQRMSVITRTLSEETMRLYVKGSPEMIASLSKLATIPANFQDQLNSYTQDGFRVLALATKELDPNLTWHKARQINRSQVENDLIFLGLLIMQNKLKPETKPVIQELQAAGIRTVMVTGDNILTAINVARKCDMIPAGEDIVRVEVEENNEGNKLRLTRLTGYKEKKTSGQDHLDDGDSEEICVQIEPTVGCRTHYAIDGKSFQAVSELNTDAMATLAVQGTVFARMTPDQKAQLVESLQDLEYRVGMCGDGANDCGALKAAHAGVALTETEASVASPFTSKIQNISCIPTLIKDGRAALVTSFGMFKFLALYSMIQFITVIICYSFQSNMSDFMFMYADIFVCTTVVLFMGRNDAYHAIAAKKPPSKLVIFPLIFSVVVQVAIQAACQVAIFFILQEQPWFVPLVPEQNSKNLVAWETTSVFLVSMFQYSTVAIIYTPRKPYRRAIYTNYLYLVDLIIIHACSLVILFYPPTAIEDLFQLKHIPSFRFKGIIFGVVLLNFVLSALVELILVPSGTIMRFLSCKRFRKVSLPAYEELKMKPVGLSDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAV0</accession>
    <name>A0A8B7YAV0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytosolic carboxypeptidase-like protein 5</fullName>
            <ecNumber evidence="17">3.4.17.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP/GTP-binding protein-like 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Protein deglutamylase CCP5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC110978661</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:63792"/>
            <dbReference type="Rhea" id="RHEA-COMP:16435"/>
            <dbReference type="Rhea" id="RHEA-COMP:16436"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:149555"/>
            <dbReference type="ChEBI" id="CHEBI:149556"/>
            <dbReference type="EC" id="3.4.17.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:63793"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>C-terminal L-alpha-aminoacyl-L-glutamyl-[tubulin] + H2O = C-terminal L-alpha-aminoacyl-[tubulin] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:63796"/>
            <dbReference type="Rhea" id="RHEA-COMP:16436"/>
            <dbReference type="Rhea" id="RHEA-COMP:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:149556"/>
            <dbReference type="EC" id="3.4.17.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63797"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>gamma-L-glutamyl-L-glutamyl-[protein] + H2O = L-glutamyl-[protein] + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:60152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15517"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:143622"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:60153"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.24" evidence="17"/>
    <dbReference type="RefSeq" id="XP_022089505.1">
        <property type="nucleotide sequence ID" value="XM_022233813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAV0"/>
    <dbReference type="GeneID" id="110978661"/>
    <dbReference type="KEGG" id="aplc:110978661"/>
    <dbReference type="OrthoDB" id="10253041at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06236">
        <property type="entry name" value="M14_AGBL5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050821">
        <property type="entry name" value="Cytosolic_carboxypeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034286">
        <property type="entry name" value="M14_AGBL5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040626">
        <property type="entry name" value="Pepdidase_M14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12756:SF12">
        <property type="entry name" value="CYTOSOLIC CARBOXYPEPTIDASE-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18027">
        <property type="entry name" value="Pepdidase_M14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="23">
        <location>
            <begin position="151"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="442"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="717"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="795"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="924"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="985"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="722"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="739"/>
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            <position position="601"/>
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    <sequence length="1146" mass="126710" checksum="9535D848582F8C66" modified="2022-01-19" version="1">MEYRSGGLLFTSKFDSGNLARVERVYHDDEDDVTIRRVGDPSPTPDYEFNVWTKPDCGGTEFENGNRSWFHFAIKGCPMNKLVKINIMNMNKQGKLYSQGMAPVVRVLPQKPKWERIRERPTYENADGQFILTFTYRFEYRFSSVYFAFCYPYSYLECQQRMDELDTQFTQCQNLSPSSPVNSIYYHRELLCYSLDRLRVDLMTITSCHGLTSEREPRLPKLFPDQSLPRAHKFRGKRVFVLTSRVHPGETPASFVFNGFLEFILRPKDPRAVQLRRQYVFKLIPLLNPDGVQRGHYRTDQRGVNLNRVYLDPDFAVYPSIFAAKSLILHHHMSSRVIASPSPRKADLKPVVGRSEKGEGEGVVAVVAPSVEVQHSPANAIVVVHEGSGEAAELNTECQTDSTMDHLHVKPDRDVVTDNQQGQAELLDTSRLDSNTAAMTAERLDSKSFMESETRSHISSVAKESSVDGDSGGEDDEDRTFQRAPQDGVTKPDPTPAADETGLNISPSESGVALYMDLHGHASKRGCFVYGNHFEDEERHVDNLLFPKLIAMNSAHFDFDGCNFTEKNMYTKDKRDGMSKEGSGRVAVHKATGIIHSYTLECNYNSGRFVNSLSPATMDDGRATPPPLAGYPPKYTPAHFEEVGRAVAVAALDLTNTNPWSRLASTEYSNVMGVRAWVQRYIRSMRGAPSLPKKMARVASKTSSIVASATANALHNRPRFSWSDTATSQTPSGPQNNPVSSSVSATTTTAAKKTATRHLGPVRETKATLERKKHLQQLQGSKLASASIPAFGSTTLRSYPLPNQGRQALPNPTTSHHSSTPQVTAGSTSSLKPHKTSLQSQSSLLQGVPHPHVHGVTNPVTHGMPPPIRHGVTLPGTLKGKPQRPSEDMQSTPNVVHELLSNVMIKALEESMMAQTRGVSKVSCVSLSPLPSPSLEAPPPSHAQAANAAQSDSSNRTAMPIPTLTPGVKVPTNHKMLFRMANNEAVASDDNINPMKQQDSPSSEPTKRRKKPSGLKRRSASHSPTRKGRRTGRGKGSETDSEKEKKQGRRRRKGSMVTSQSDPLTSESVPDLNIGPQNGHDQTPLRRRSSDFASPDIASHRSRLAARFGKSHSLGENPESSVSCQVVDLNSMNSNWKPKKEVSFWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCU8</accession>
    <name>A0A8B7YCU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110979526 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110979526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091079.1">
        <property type="nucleotide sequence ID" value="XM_022235387.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979526"/>
    <dbReference type="KEGG" id="aplc:110979526"/>
    <dbReference type="OrthoDB" id="161570at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20104">
        <property type="entry name" value="MBT_PHF20L1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20386">
        <property type="entry name" value="Tudor_PHF20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041297">
        <property type="entry name" value="Crb2_Tudor"/>
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    <dbReference type="InterPro" id="IPR004092">
        <property type="entry name" value="Mbt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043449">
        <property type="entry name" value="PHF20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PHD FINGER PROTEIN 20-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tudor/PWWP/MBT"/>
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    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="844"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="300"/>
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        </location>
    </feature>
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            <begin position="694"/>
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        </location>
    </feature>
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            <begin position="878"/>
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        </location>
    </feature>
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            <begin position="1068"/>
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        </location>
    </feature>
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        <location>
            <begin position="1199"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1417"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1493"/>
            <end position="1710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
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            <begin position="53"/>
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        </location>
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            <begin position="140"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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        <source>
            <dbReference type="RefSeq" id="XP_022091079.1"/>
        </source>
    </evidence>
    <sequence length="1788" mass="195593" checksum="E3371B999B38F17D" modified="2022-01-19" version="1">MRAKTRRSSGKRKARGNNMADESGVLGASGMLRPSANKEDEQKAPVSEKTTEEIDVEGTSDEEVEDSRSTTSPTADKLAQTPKESSPKEGGDRRNSGADSTEKHSESPLPPKQELEKQASSPAGKSLESAPVEKLDSGIPEQNQGTSVGNNKLEKDQVSQSEKKDTSEEHTSGPSYKETLEGSGDEKIAEARISGSGVVVIPKSDSRKEISAQMAPTDAQSAEKTLEVEVKGLAKPQKLKTFEDAFKASIGKLNVEAPRPRKVIKPFGNFIKQVGGAAPGPSSETFHLRQRDNEKVINVTEKQKGQSSSSGTEKSSGSQQISNQYLTKSPKIDATDNQKFDADMFEDERDNSRDIDNFSSDSSSTIIDIELTAKESTEEEISGKPSRPKVASQPTVESQSQESKPVVAEKEKSASKARTRESTSKPNPTSDTSSGDGTSEEQKSPSTKQPSNENANTGTKHSKEEGDTKSSGLERAKVSDLTRHKGNGDHDRKLEKRRELLRAKHAADQPRMKPETKGDGKAKLRERSKSEESPTSQAKKYRVSKHGIVLQPGMKLEAMDYSKKWYLARIVNVDETDNTVLIHFAGWNSRFDEWLEFDSDRLRPLARVSARRETAKEVKALGGYRVGDEVLARWSDCRYYPAKILGIKTNGSYRVLFYDGIEKTVMGINVRDMPESLKSQQLFSNLEHQFRALVNKKRRSSRDAEGKSKEARLSKESLSGSRPSSPIQQPQKRRHPSTNQSPALKPAKRSRQDSSRSQKAQKGSVKTPEPVPPAPVTRDQPELLPSPTSAEASELMSALEHGMMGGKKCYREPLIFDKNTGLIRDPSRLVAPKELVIDLDHNKYKCEVPDCGKAFRKASLLEYHQKYYHISKPATSTSAMAAAKNAVTRSRKRLSTSASTPGSSKMRRTESADGPSAKITSRQHRISAPGILTTSHKHPLPSPKLDSLTPTPPHPLKSMSTNQFVKRQAVPDTRKPLPASRVERPPLTKPDLASPTVQQPQAAAKPKAQGSEITAKVAERSRKVSGSTASKESKPTTNKSEVVTTTVSEKLQPSPKAAALTLETKTKAELSDAAPTQQPETKSQQAPVALDSKADSKAVVKGPEVTAEIAAAPHQAPKKQRRNKPHKKHKRHKARSRDRRSREQSRSERRRAAERAKQRRLEQRQLKQSLEEAASRQKPEDVMEWTAKYLSATTDRNLLHSPAQSSDDPMLKPEGLDSSTTEDGGPRDMISCVCRNQEEEGFMIQCETCYGWQHGSCVGLTESTIPKQYICSFCIYPENLRTHARHRYDQDWFRTGQLSSLTQPQQPAEESGHLTEAMLKTHQLMADMISVTEALDVLQHKLEILKSDNHPDLKLWSYHWGLRDESTPLDDSAHTQQLQTSLEESDVLQTSAETSALTESMRSDVVVDSIMEEVIPEVVGTGTDDVSKESSGAAAGNQGDIGDSGDMGLLQEGVKHAEEFDFPSVVGKTLIPNKNPVPEETVGCLDSVNAEASPVEVDSKELLESSTFSTPTTTSDSKQDNMSSGSAPSVPDKGTPLSSTLQAETLPTEKLTACIIPDPEQSTSQGAKDGVTIESGKPVTPVHDGKSDRAERDNLQNPKGNSSGDAHTMLGSGTSSQASEVKDPVTSETQKVGTPEHDGKADSSTKEQPANHGDSSDDEPLIKYTKKSASSSEAENDTTSVAAKSTTPPPQPSSEPAPVQADPVPSGNPTVPPSICKLHLFNHIVCVEEELKRRMDYVEEQIEALELAFNQSAESKDSQYNPPDPLQMKRTISVLMDDLERVNKLVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEE0</accession>
    <name>A0A8B7YEE0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">28S ribosomal protein S31, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110978940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089991.1">
        <property type="nucleotide sequence ID" value="XM_022234299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEE0"/>
    <dbReference type="GeneID" id="110978940"/>
    <dbReference type="KEGG" id="aplc:110978940"/>
    <dbReference type="OMA" id="NFMELVC"/>
    <dbReference type="OrthoDB" id="5989925at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026299">
        <property type="entry name" value="MRP-S31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13231:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15433">
        <property type="entry name" value="MRP-S31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022089991.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45286" checksum="AF10927C6F7938DE" modified="2022-01-19" version="1">MRRIWQRVSNLYCVQNERMLRIRVSGPRSTSTPTTTTTSTRCYSTKGKEDETNAKTSSPPQDKPSAAKDLLSTLTGLKVEKNLSSKVGSSPRLRSAAADFRDLLSAKKTKSEGGSDLGSKRPEDITRMVVETAKVVAEIFPEKEVVESDLLKQLRKHDEATAAGKQGDLEAVSSILSGIKIEKQTAGQKERDQTRSLDERALAGAFGSGFEVGGETGHEDRRGHGHKQKQTVRRQQRKTLFDRSRLNIFDPAADDASEAHELSPKEPTVPSLWDKEEDKQLRQLTYSTINHGFDELIKWTDEGKIWHYPVDNEQGLEEEQEVPFHEHIFFDHLLEDLPQIEPIQNFMELVCVGLGQNPYLTVQQKHDHILWFKTYFKEREDVIREAMEADRAAEARETAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YF93</accession>
    <name>A0A8B7YF93_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulator of G-protein signaling 7-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110979604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091262.1">
        <property type="nucleotide sequence ID" value="XM_022235570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YF93"/>
    <dbReference type="GeneID" id="110979604"/>
    <dbReference type="KEGG" id="aplc:110979604"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08705">
        <property type="entry name" value="RGS_R7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000001">
        <property type="entry name" value="Putative regulator of g-protein signaling 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000162">
        <property type="entry name" value="Regulator of G-protein signaling 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1240.60:FF:000001">
        <property type="entry name" value="Regulator of G-protein signaling 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047016">
        <property type="entry name" value="RGS6/7/9/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047017">
        <property type="entry name" value="RGS6/7/9/11_DHEX_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040759">
        <property type="entry name" value="RGS_DHEX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034483">
        <property type="entry name" value="RGS_Egl-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746:SF6">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18148">
        <property type="entry name" value="RGS_DHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="3">
        <location>
            <begin position="40"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="373"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022091262.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="60261" checksum="259F343F87B353A2" modified="2022-01-19" version="1">MAHWRRVNGVEEDGDSACSHHPHHIVYKKVEKLIQKMQDEKNGVPVRTVKSFMSKVPSVFTGADLVQWLMRILDIDQVNAIHLGSLLAANGYFFPITDHVLTLKDDNTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKSRLELADYEAENLAKLQRMFSRKWEFIFMQAEAQAKVDKKRDKMERKVLDSQERAFWDVHRPVPGCVNTTEMDIKKLSRINRTCKKKKMNFGAGGERISPCASDSDLRSHSEELMRTDASHHEHLHFACCSPILFLKRKVEMQKARLEKRQYKTSKVAELGDIAFTMLRLVQRPDRLISYCQQYRDYDSFLCAPTEGSNPWLSDDPSLWEAATTMNLKDVPVWRVKKWGFSFDDLLKDPLGRDQFAKFLAKEFSQENLRFWVACQELKATAISKVPAKAQEIHDEFLSEASHSPINVDSKVREVTRKNMKGAAGRYTFDSAQEHIYTLMRSDSYSRFLKSDLYKELLNPKKKCQSHWEKQQSKFLHHLTSFHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFX5</accession>
    <name>A0A8B7YFX5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integumentary mucin C.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110979754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091492.1">
        <property type="nucleotide sequence ID" value="XM_022235800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFX5"/>
    <dbReference type="GeneID" id="110979754"/>
    <dbReference type="KEGG" id="aplc:110979754"/>
    <dbReference type="OMA" id="ASEMACT"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017994">
        <property type="entry name" value="P_trefoil_chordata"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13826">
        <property type="entry name" value="INTESTINAL TREFOIL FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13826:SF14">
        <property type="entry name" value="TREFOIL FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034901052" evidence="3">
        <location>
            <begin position="16"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="4">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="4">
        <location>
            <begin position="72"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="4">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="P-type" evidence="4">
        <location>
            <begin position="204"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022091492.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="41042" checksum="B507575C3EEC097B" modified="2022-01-19" version="1">MRLYYLLLFVGLCAAYEPWLCPTELLESERTDCHPEPGASEMACTARGCTWCRAYDPSAPWCFFNTKPGYEGTCPSTVPTSQRVDCGQPTNAQCVKTGCVWCPETGGPWCFFDEDAGNSPTSFSPGTDGPVVTGGPTTSPSTTKHYYPGCASSIPPDQRIDCYPEPGSSEAGCLARGCYWCEEATPGVPWCSHPTLDPVDPIDGMCPSDIPDANRRDCYPDVGASKDSCEARSCIWCESSVSGTPWCFFNITGVSPDPAQDVYRVDCAPDGRCDQCEARGCELAGTDVQGAPLCFFPVDLGYTMSGFAETPTGYLVALKKKHDFTVFGDDVEQLVLSVDFQTDQRLHFKVTASHIPISLSYVSRMDNPDQISREGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGH5</accession>
    <name>A0A8B7YGH5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Endonuclease V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">LOC110980207</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Interacts with PABPC1; the interaction is RNA-dependent and stimulates ENDOV activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092339.1">
        <property type="nucleotide sequence ID" value="XM_022236647.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092340.1">
        <property type="nucleotide sequence ID" value="XM_022236648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGH5"/>
    <dbReference type="GeneID" id="110980207"/>
    <dbReference type="KEGG" id="aplc:110980207"/>
    <dbReference type="CTD" id="284131"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2170.10:FF:000002">
        <property type="entry name" value="Endonuclease V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2170.10">
        <property type="entry name" value="archaeoglobus fulgidus dsm 4304 superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511:SF1">
        <property type="entry name" value="ENDONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022092339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022092340.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38895" checksum="E0A1F03B2694B03D" modified="2022-01-19" version="1">MQLVLQPVGQKCKILRAVAQEHITAMTAHDASRVMANVPVQTDEVFEEIHKKWESEQQELKKKLVLENTESWQSDLDGLRCVGGVDVSFVKTSSTLACASLVVCDYPDLKVIYSDCELVHLDTPYIPGFLAFREVNFFLNLLHKLRDKEPNLMPQVILVDGNGILHPRGFGIASHLGVLSGIPCVGVAKTLMQVDGIAKNEQFAEKVAELGSGGDTFPLMTDSGQILGMALRGCHKSRNPIFVSVGHRISLETATKLARRCCRYRVAEPVRQADIRSREFLREMYPESSPGKRQPQAPRSERYKQTQDMARPFPANEVRVGGAKGNMCFLDDHSGPSDEESHFDCLFGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH55</accession>
    <name>A0A8B7YH55_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110979890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022091730.1">
        <property type="nucleotide sequence ID" value="XM_022236038.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979890"/>
    <dbReference type="KEGG" id="aplc:110979890"/>
    <dbReference type="OrthoDB" id="6159649at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990404">
        <property type="term" value="F:NAD+-protein mono-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12547">
        <property type="entry name" value="RRM1_2_PAR10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000008">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034464">
        <property type="entry name" value="PAR10_RRM1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF102">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP14-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1166"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1405"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1635"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="2012"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1591"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022091730.1"/>
        </source>
    </evidence>
    <sequence length="2209" mass="244813" checksum="AE415C5911C8F278" modified="2022-01-19" version="1">MDTSSRSVYAGLPRNEFTECKLGELQDKVWIYFQRKNISHGCDVDSVSRVDSGTSDKIWMKVTFSDPSGVQHVLSKARHELRVEGCGTVPLEIRECLQSDVQLHESEDSEDSFVILNAGDLDKGTLDGENPGEHLSALDSDHSSNAGVQLVNQQSSSSRDTANPISIPEAALPYTEKVHTLKPLITAIFQALSDGQVSTHLTPSPARILSSQSHGDETPHGEMSVGAATDDEEDDLYSPDSSIQSAATETPNLMKILRSKPTDDAESGDARKGSDFQDKGPFQQQTNEPVGSRPGYPEKTVGIHQQQSVGGSVDRGGSSQRPDARGAVLDGRCQQDRGGQVLQERNKSANGQVLAKAATTKNRSCSETSPEEKHTAEERNEYSEVSLKRPAWEQQFPQEDSSDEEKEQEGKVQKEDQEEEQFVEVTGFNPSSEEMLKMYFENFRRSGGGDIKTWEHDPKAETVRMTFEDPSLTDNVIARQHKVGGKNLTLRFKKSRPRPVKKRCLLLKGIPDGCTSEFLTMFIENECGTEDFKIQYGEMPGTALCTFNEDIPDMDKVIRRISSKTIKGVYMTAEKMHESGGILVQGVSPKVSLEVIELYFGNKSKSGGNDVREVQPGPMHTQATVYFEDWKVVGDVLAKRGPHKVGGVELSVEEYHECLGRLSPFDVSTPHTPMPVTVQVPQPVMEFIFGQKGQHAKETLLQKLSDVKATLKWPDGDDKTTARLKPLFEDGQWQSSWLKWPEVAPEVLTDFLNRFKSTRIPIPPPLWKETVARIDQVDTKGLSIEPNNTQHIVHLVGEQQDVAKRVNVIGEIVKELRTTAEYKVKQENEIKQEIFFTPDKFQHFVVCGIKDEIENRFLPNLKITVTTSEDKRRLTFQGTQKNVQEAELLTRRKIDSLEHVKFKASSNKTQFVNSLKDKIHEILRSQGIRAACMGSDDSTIIVYAATKEDASQAKAYIDQEIVEDFIPITGQAASDVLRSSNGRMLLDGINNQKFIMAAFSDSTGKVLQLVGFKTNMDKTKQKITIFLKDNIIMTKIIPANKMKIQLITIFHGADMVNVEKQFARNQVKIQPQMRGQNKGIVIQGNEEGLEAASQFIASLIARIKEQLYPVSRTGMAQLFREDKGRKFLESLEMKFECVISENVEEGSDEEEEAQAGRETRPLMTSEILCQITLPNSFTLKVCRGDLTMQKVDCIVNAANVKLKHGGGLAADIVEAGGTVIQTECEQILKNKHHRQLHVGEAVCTSSGSLPCKKVIHVAGPQWPHDKTAIPRADDEPTQEEVLLYDSIIECLKLANQNKMQSIAIPAISAGIFGFPVELVARQILNAAADFCQNMRNLTLTEIHFTNNDQPTCNVFRQAVMDRFGPFQGREAATGVRQGPTATTFSPPVMEDDTPVSAPAPKFTASGQNSLTTNEGITITLKKGSITNEMVDVIVNTAGPDMNLSSGKVSQALLKAAGSALQKECDTVITTRGKVRRGDFIETGPGALTCKKIYHCVCEGYRQGESEKVLKKLILKLMEQAEQNEMLSIAIPALGTGNLNYPAGVTAQVMYESILEFSNLHPNGLLKDVRFVVYDKDAKTIQGFEDKIQRLSTPGTSAGATGYAPSGLRRKLRKSGSASTPSDRQPESYSEIVRDQTGMLQTKIGSVCLQVGPGDLRTETTDAIVKSVGPATYQQAPIYVQTGVSSLQCSGIFHVVTPKSPEAMKTAVHKVLKLAEETKLKSVSFPAIGTGQGGLSVADSASAMLAAVGEFAVQKKPRHLHLIRLVIFQPRMVTGFQDALKKEVGTSYKKQKGLVSKGIGLAKSALYTAWYGGSTAADDQTEKGSLEETIILNICAMDMASIKKAVDKIEQFQSEEYTSEDKLDDMEMLDKMTDKNHTEFKDIEAKYSVKITYPIKRGGDKFVRVEGRVINVKDALIAIQDVFKKMHKDLLQAQQMELLSKEVQWKYSTPQGEEAYDPELNAIIEKAYKNKQPSVALDLEDGKVTINFQNMEESSRAGTLQVRRTNLSKVAAFEMPPNWIPMRDNDHFKMAPLAAGTSEYIAVERHLQTTSAVQQIQEIQRIQNKELLMQYKTLKAAMEARLGRPDIEKTLYHGTDEKTSDKINKQGFNRSFCGKKATDYGNGTYFAVKADYSAQDKYSNPNANGVKHMYLAKVLVGDYVRGSQGMITPPNKPSHPDQQYDSVVDNIYQPGIFVIFHDAQAYPEFLIKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJF4</accession>
    <name>A0A8B7YJF4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">oligopeptidase A</fullName>
            <ecNumber evidence="8">3.4.24.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110980288</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-|-Gly-Pro-Ala is cleaved, but not Z-(Gly)(5).</text>
            <dbReference type="EC" id="3.4.24.70"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.70" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022092540.1">
        <property type="nucleotide sequence ID" value="XM_022236848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJF4"/>
    <dbReference type="GeneID" id="110980288"/>
    <dbReference type="KEGG" id="aplc:110980288"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06456">
        <property type="entry name" value="M3A_DCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000009">
        <property type="entry name" value="Oligopeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1370.40:FF:000005">
        <property type="entry name" value="Organellar oligopeptidase A, chloroplastic/mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034005">
        <property type="entry name" value="M3A_DCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF83">
        <property type="entry name" value="LD37516P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034655663" description="oligopeptidase A" evidence="10">
        <location>
            <begin position="32"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Oligopeptidase A N-terminal" evidence="12">
        <location>
            <begin position="105"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="11">
        <location>
            <begin position="307"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022092540.1"/>
        </source>
    </evidence>
    <sequence length="757" mass="85800" checksum="4A94990DED8EDB5F" modified="2022-01-19" version="1">MRAAHRLARLQHSLNWLLIALHLALMPLLLTLELSSASTSPWQPSCPAISDFRLFVSRYSPRIGGPSVAQCSTVAQSGRGNPLLRYDEGLPSFRSIEVEHVVPAINQIVGDFEEGLEVLESQYEALGDDVSWSKVSDPLEKLEAPFDFGWGVVTHLNAVKNSQQLRDAYQQVQPLVVKATSRVTQSTPLYRAVKKLNGSGAILDGSQRRLLESAIRQARLGGVELTGDNKERFNQIRLRLATIATQFSNNVLDATKAFSLELTDRRDVDGVPASLLQLMAANANPEKPDPEIGPWKVTLDLPCFEPFMKHSTNRELREKLYKAYITRASQGDHDNTDIIEEIRALRKEKAALLGYANYAAMSLSSKMAENVDNVWALIHGLRDKSKEAAKRDLQQLQDFASSRGFDGRLQLWDMAYWSERQREHLFKFNDEDLRPYFPLPHVLEGMFNLTSFLFNVQIKPADGTVETWHEDVRFFNILNEQGEHIASFFLDPYIRPAEKRGGAWMNVCFGKSELLNRKPVAYLVCNQTPPLKGKPSLMTFREVETLFHEFGHGLQHMLTTVPYAGAAGINNVEWDAVELPSQFMENWMYDARTMRAVSRHYQTGEPLPDSLFDQLVKARKYRAGSAMLRQLYFSAMDIELHTSTDHWMDVMRRAADEYTVTKPLQEDRFPCSFQHIFASGYAAGYYSYKWAEVMAADAFSAFEEVGLDNKESVAQVGRRFRDTILALGGGTHPRDVFQQFRGRDPSPEPLLRTYGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLL4</accession>
    <name>A0A8B7YLL4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NXPE family member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094159.1">
        <property type="nucleotide sequence ID" value="XM_022238467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLL4"/>
    <dbReference type="GeneID" id="110981157"/>
    <dbReference type="KEGG" id="aplc:110981157"/>
    <dbReference type="OMA" id="NGTWYCG"/>
    <dbReference type="OrthoDB" id="5950832at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="2">
        <location>
            <begin position="346"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094159.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="65547" checksum="6489B9AFF758650E" modified="2022-01-19" version="1">MTSNGKLSIGYKDTNYCTNVWRRKPSMRGLLLWLGLAGMGYLMLSFFTTGHVQLSNPQPSQRKFSTRMLGSVQNIISNYLAKLPNVTPATLSNPTVAGNSFFYIQYPKASYNVCDQLALYIEARDKTNKTKTRGGDFMWPYLQTASLSASTPADELIDHGNGSYAALFTLNWAGEIEPFVRFVLSSEQSYSVRKIRDRIPYRFAYDAMFTDGKTIEVTPCHITKDIYVDKAAKELSLASKAEVCDFSDPRIGSTWYCLKPKTLSCSNRSQHRGNIERGNSYLQQALQDEKVSLAKPEMLQNIGKVRTVKVMSKVSDSACLDLPPCNSGLPPKRANRAAGYYFKDLWKSKVCIARELQLKETIECLRNKHLFFIGDSTIRQWFLYLVSHLGQNMTEYKIWTKEDVIQMHRHAFDKVHNITLDFRFHYYPILGNWLNTTTIYSAIDLIDSLPGGRDTVLGFTMWAHFTYTNLTYYLSRLEPIRDAMIRLQERSAGKATVIIKSANTGILPYTPEITELLSYDLDQMMRAFFAEIPGVTVIDVWDMTVSPRGEYDVHPCELVIREEIKMVLNFICRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YM53</accession>
    <name>A0A8B7YM53_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17 18" type="primary">LOC110980297</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022092551.1">
        <property type="nucleotide sequence ID" value="XM_022236859.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092552.1">
        <property type="nucleotide sequence ID" value="XM_022236860.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092553.1">
        <property type="nucleotide sequence ID" value="XM_022236861.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980297"/>
    <dbReference type="KEGG" id="aplc:110980297"/>
    <dbReference type="OrthoDB" id="641149at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11725">
        <property type="entry name" value="ADDz_Dnmt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05835">
        <property type="entry name" value="PWWP_DNMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.50">
        <property type="entry name" value="PWWP, helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040552">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049554">
        <property type="entry name" value="DNMT3_ADD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF25">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE DRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17980">
        <property type="entry name" value="ADD_DNMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21255">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="13">
        <location>
            <begin position="1072"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="1262"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="48"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="221"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="278"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="643"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="719"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="763"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1207"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="725"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="797"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="827"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="869"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1220"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="1490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022092551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022092552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022092553.1"/>
        </source>
    </evidence>
    <sequence length="1697" mass="190047" checksum="E16B285C98591291" modified="2022-01-19" version="1">MPFYGKQSLLRVYHKWNVFKRKNLDRYIEVVHGKAFLNELKKNLSKTGQYKQSTVRQVRSQQPKKEGHFPSKQGKSSNTETTTDEEKATTLKEKPRSKHDVPQAHRRESQDQGSESASMRRRQTRRRASKGIFSATELTGDASKKIKEAGGPQAGAGRMQSPTTRDRSSVMVQDDGAFISSRTRLARSIRRNGKEGNTTQDCHHEAALAQRSEDVLSGVKGETTTVDNPKSPSFCQDKTSVEPATMSPRTEDDSSLKGERIELDLLASETGFELQKIQPLNADGESSPVLPSGSHCEMEDILPPAKPKMTGQPTPEQRGHVLRKKRVSPSHQRRTRQRSRSSRHTPGNYEDSRKNFVTNETSMHQPSSTSELEVREALTESAESSTTALMQGGLSRSLGRVITTQRGIKLRQTARKCCPQPLRGTNNDHGEQLSLVGIHPFTSTPVDKIKGFGPFSRRISVEVHRMKEPVSLSPHNQVSQPVGFIRKLGNRSPAKNIMPEVRRQDEEQHEGNREAPVIVGSKAPKVVSVSRANDSSEQDRVSALSYTALCYRGSDNDGASPRIENTRYASKNTINPVTKKTQETLDENLWNLSVVAAIEDIPLLEDDDERRKSSPNELDEVISEDKDCQQSLQVRHNVAVNNPDFMPKGITSLRQGEDVDRKPENDVNTSTVDESVEDGDGILISGNCLPGLSHLHEGPTENNSPQVDSPIIPVLASVHPHSSRESQAQTMNQTPSSTRGRSRNNQENMCMPSSYFQVGKSWLSSQMTSQDPEESTENASSTLSQRHSDGNVAKVTSKYQSADARSSIQIPSDTEEEASTELAAAVPERRSSPMAEVKTEDSSKDDTKKTDSSVSVETLVNDETQCTPELKEPEAAPRKIKTPAEKKQRWLSQQSLIKAPGEPQAKEGRLNQEGQQLLSQMTQEERDLVSGEKGLITRKRKRTDSQEGRVRGQSGWEESLRQKPAVVTKFQAGETPKSLKKPETEKKKQSPKKNSEPFQSPSKASKEKSHLLQQKMPFRDVLKPPPSKKMKLIDEGPDPAPKSSEEDESSKPTAAQISSPCPSRPLQDKYRYGQLVWGKMKGFNWWPGTVVHHHTCGRDAAASDACWIKWFGDNKFSKVNLNQVIPFVQFSAHFSQSTFLHTALYRRAVFQALQLASTRAGKTYSNDPAQYRTEVPKHSRHSNPAWQKFYELCTDMIGWAKEGFEPGGQDAIMPSEEEQQPPPRPASPPLSPVLSSPTKKTGHSSSKAAETWKDIRDTVIPEVRNGIKHIEDICIGCGSAALTAQHPFFIGGLCEVCRVEFVEMAYVYDEDGYQSFCCICAEGSDIILCDQPECYRSFCHDCIEHLVGPSSVKEILDEDQWKCFMCKPEPTTGLLTRRPDWPQKLLLFFQQDRSQTFPPMKTYPPVEMDQRKPIRVLSLFDGIGTGMLVLKELGLKVDCYFASEINEEAMQVSSVRHDGIIQQLDDIRKITAQEIRSLGPFDLLIGGSPCNDLSIANPARKGLFAGTGRLFFDFYRLLTVVRPNADSQRPFFWLFENVVGMPHQHKMEISKFLECDPVVVDAKDVSPAHRARYFWGNLPGMNRPNIATDKNALCLQDCLEPNCNRQAQFSKVRTVTSKLNSIKQKNEQVLPVLMNGQEDALWCTEMERIFGFPDHYTDIANMSRTSRHRLMGQAWSVPVIKHLLAPLKEYFTCEMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMI9</accession>
    <name>A0A8B7YMI9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CKLF-like MARVEL transmembrane domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110981303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094474.1">
        <property type="nucleotide sequence ID" value="XM_022238782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMI9"/>
    <dbReference type="GeneID" id="110981303"/>
    <dbReference type="KEGG" id="aplc:110981303"/>
    <dbReference type="OMA" id="HKIKIPW"/>
    <dbReference type="OrthoDB" id="10028364at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF102">
        <property type="entry name" value="RH30783P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="24"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022094474.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19044" checksum="D3B984E8CAFAC00C" modified="2022-01-19" version="1">MADRKQIVLPTISSLTYVPTGLKYLTLPEGILELIEVVCLVVAFVCVTAAPNKAVDESSYWHYQAATMGFCLVTCLIMAGYMTGLIHKIKIPWSVLEIVYCAVAGLLLLTTGAHIAANVHGNAVLIVATVFGFIAAAAYVVQIFFAIRAWKRSIIAATLKMVEAERAQHAGTSDNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN52</accession>
    <name>A0A8B7YN52_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Potassium channel subfamily K member 16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110980492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092896.1">
        <property type="nucleotide sequence ID" value="XM_022237204.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092897.1">
        <property type="nucleotide sequence ID" value="XM_022237205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN52"/>
    <dbReference type="GeneID" id="110980492"/>
    <dbReference type="KEGG" id="aplc:110980492"/>
    <dbReference type="OMA" id="FGQCSER"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="118"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="10">
        <location>
            <begin position="211"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022092896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022092897.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49073" checksum="8DF1F27D1FAABBC9" modified="2022-01-19" version="1">MFRAQLDTTASIRSTSSVAALTGFSRRHQGASVKRLVLLLVVYVIYIVTGALVFRYLEGGNEENLQDRIRDFVAEFLANNSCINSSELVTLVDELVHSIDNGLKPAVGDDTLDYYGHHLWDFPNSLFFATTVITTIGYGNMSPRTSEGMAFCVVFAFFGIPLTGWFLAVFGQCSERHWKSFTDKFDKTVAFLKFATAQKVAVYTSLALLLYLVIILLPSTVIHFVEGWSWGVAHYYTFISLSTIGFGDYVAGNGTNLHAVTRTLYKIGLVLYLILGLAVLTLTFKVTQHYQRKNASRMQSVTRGVARRVLSKRRNASFEKEKQDKENRVTVNLRTAKYGRCDSESGETFTISIDEFGRCLKDASTQTNTSSVESNVKTSIKKTGNSIIITSSQSGVLRRSLSWSDMQEGIVIDMGKSDSRRDHENGNVLLRNNLGYSGDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPY5</accession>
    <name>A0A8B7YPY5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110981769</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095338.1">
        <property type="nucleotide sequence ID" value="XM_022239646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPY5"/>
    <dbReference type="GeneID" id="110981769"/>
    <dbReference type="KEGG" id="aplc:110981769"/>
    <dbReference type="OMA" id="WIRWCCK"/>
    <dbReference type="OrthoDB" id="10592220at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034026290" evidence="2">
        <location>
            <begin position="22"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022095338.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29827" checksum="B357269530D2749B" modified="2022-01-19" version="1">MVVLIRISFLALLTSVAVVLPEGRYDVVLQGSDPTITQVKRSLDSHHNYRVERHVSPGNEPKHTLDETRSILTSVVTNLRKTRLNQHSQKSREGSLWQKDLYRHSQRQNGHRNSWWIRWCCKIFWSKKYCGEEEPNMTTEMVTPVETTAIPETVSIMSTTAAEPTEEPTTLGESPPPSTTRVAMATESITTLAMTTENRITEAEFTEKVTSVSQRQTNTLGTPHITTTEESNTVPNSETTVTSTMTSESSTQKVTVRPTIGDPIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YR36</accession>
    <name>A0A8B7YR36_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Papilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110981571</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the papilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094920.1">
        <property type="nucleotide sequence ID" value="XM_022239228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981571"/>
    <dbReference type="KEGG" id="aplc:110981571"/>
    <dbReference type="OMA" id="IVMLVQD"/>
    <dbReference type="OrthoDB" id="5950222at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000017">
        <property type="entry name" value="papilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938">
        <property type="entry name" value="ACP24A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938:SF11">
        <property type="entry name" value="WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 15 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="9" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034310889" description="Papilin" evidence="18">
        <location>
            <begin position="32"/>
            <end position="2572"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="759"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="822"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="880"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="950"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1008"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="22">
        <location>
            <begin position="1063"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="22">
        <location>
            <begin position="1140"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="22">
        <location>
            <begin position="1213"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="22">
        <location>
            <begin position="1286"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="22">
        <location>
            <begin position="1356"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1425"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="22">
        <location>
            <begin position="1608"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1676"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="22">
        <location>
            <begin position="1731"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1800"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="22">
        <location>
            <begin position="1860"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="1929"/>
            <end position="1979"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="22">
        <location>
            <begin position="1986"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="19">
        <location>
            <begin position="2055"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="22">
        <location>
            <begin position="2116"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="2247"/>
            <end position="2332"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="2344"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="2432"/>
            <end position="2519"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="21">
        <location>
            <begin position="2525"/>
            <end position="2564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1482"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="710"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1482"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1505"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1534"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1581"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1592"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1099"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1177"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1323"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1390"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1642"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1765"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="1894"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="2020"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="2150"/>
            <end position="2157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022094920.1"/>
        </source>
    </evidence>
    <sequence length="2572" mass="281068" checksum="3835A6F9523EFC1A" modified="2022-01-19" version="1">MRSSLESTLLLTVAALLMATVLLPSPPYVTALPRSARQAPVAEDTWGPWSSEWSPCSRSCGGGVSYQERRCITTRPGAKPTCMGPAFNYRSCNIQDCPEGAQDFREEQCSKYNTKEFLGNFYNWVPYLGADNKCELNCMPKGKNFYYRLAEKVVDGTRCEADKLDVCVNGECMKVGCDNMLGSDAREDICRECNGNGSSCKTISGAFGRKKLPFGYNDILVLPAGAVNIHVAEVQPSNNFLALRNANGQYYINGNFTIDFPQPFEVADTVVYYERKFGAPFYGAEALRALGPITEPLFVVLVTQERNHGVAYNYSVPLDSEGAKPDTYSWLFSDFTPCTRTCGGGYQLRDVWCARSSDFVRVPEYLCDPALKPAGNHSCNMVPCPPSWLAGEWSPCSTSCGLGQQVRLVYCEQVMHGDRAEIIHDSFCENGLLEDKPSYQQHCFSAPCPEWTAGNWSQCSVTCGRGVQTRAVSCSSGEEVLADSQCLADIRPNSQQVCHMGPCEDVQWLVSQWSDCSDQCGDGVQTRQVHCMGPSGTIYAEDVCDGNLRPATTQRCSSRQACHPLWHASRWTECSTDCGQGLRIRNVFCAHFVNGEWEATSDGACNATIKLSTSEVCDNGPCVGAVWLTGSWEKCSAKCEGGQRARQIMCFKDGTSLDSSHCDASNRPIEQEICNTQPCDGSEEDCNRSTYGCCEDGVTEATGPDQEGCPTSETEAPTSAPSTTTGPTCASSTFGCCADGINAASGPDGEGCQEEKETCEQPYDTGPCYAFELKWFFDIEYQRCVNFWYGGCEGNANRFDSEKECQSVCTIQQEPMTQEEMCSLPPEVGPCKKSIESYYFNPETGQCESFTYGGCHGNMNKFRTPEECDIKCGTLNKDPCTLPLEHGNCFETHLRWFYNIRTQQCEQFNYTGCLGNPNRFEDAASCEERCGVVDRVPDQPETTGVVVDVCGLPKEHGPCRESILQWYYDTERNSCQQFIYGGCLGNANRFDSRVTCSQACISYGAEQCSLPIEPGPCFGYFPTWGYNATVGACQPFVYGGCQGNDNRFDTQDACDHACGPKAITKCRRSRNYATYVAQGRLGAFIPQCTLEGHFEAMQCHGSTGHCWCVDMNGREINGSRRAPGIHVQRPDCEAFQPRTLTTCQRHLKQVQGKNGQAPPGRYVPQCTEAGEYETVQCYGSTGYCWCVNVNGEEIDGTRRGPGMGSPNCDGGAQGPCPSLALQLQAGQATNDYQPVCTPDGLFVRVQCDGVPQCLCVNETTGEVLKVLNEVPLDGDFDACNDAHQEPTRCQQHRNSVLATEEPTGHIRYVPECNEAGDYREIQCYGNTGHCWCVNDNGEEIDGTRKRPGEGVPDCTVKDCHAAREEASSSGRIGHYIPQCTEEGLYTPTQCHGGTGYCWCVDENGEELTGTRRGPGDEPVNCEDVCSLPKVTGPCRGYFPVFGYDAMMGSCDKFIYGGCQGNANRFQTREACLIACTDYQPQPTTVLPPYTTQSVSPTESPDERSTVSSPTSSPPVSSTAETPSTAPSAPPRAPSTPSVASTAAPRVTASSSPASRSTTTAPSTTTPASTTLSVDPTAAVTERQSPSPLPDSTGSGQPSTTPQTTTLISSMCEIQRKEALANTLPGVFIPQCQEDGSFVPKQCYELIGQCWCVHQDGVEQGGTRALINEPLDCQDICSMPEFRGQCPDNIQKWYFNTEAGVCETFTYSGCQGNLNQFDDQATCEQTCVTPEPTSCPEKRKTALARGLLGEFVPQCTEDGLYASKQCHSSIGHCWCVDEEGMELGATRRGPGEEMLDCDDACSLPKFSGPCKGSSAMWYYDVITERCKPFNYGGCQGNGNRFETEAECQTTCYIPEVTGRPPTTCEIQREEALTSPRLDAFIPQCTSDGAFEARQCYDLISQCWCVNENGEAQGGTRTRRGQVPLDCNDKCSFPKFVGPCRGNFPKWFYNMETMSCEEFTYGGCGGNMNQFNSQEECQQACLPQGPEMQSCQMQREEALANVRPGQYVPRCTEDGWFMPQQCHESTGQCWCVTETGMEQGETRREPGMPLLDCEDVCSFPQATGPCLGYFAMWYYDTEEQACRRFIYGGCQGNGNRFESRAECEQSCVVQVTTTSEPVSLCLVTRQNAQSQNVIGNFIPQCTEEGLFVRRQCHGSTGYCWCVDEMTGEEIVTRVPKDPRARPDCDVYYRNDTVRIGEPSNTTQPTDRVTLSPSHPLGDEGCATSTFGCCPDGVTQASREDHLGCPGITPAMVEVAPSDSTVVLGGTLTIACRAQGSPTPTVTWHREDANVEDGRDSRISVSEDGTLVIEDVVEADSGLYVCRASNGVGQAAKVAVDVNVFTPVQIPETSQLSVRAKEGDVVELHCRATGNPKPVVTWERGVVFLPDNDPRMSQLEDDTLRIENVELGDSGNYVCTGRNMFGTVQKKTITLTVEAEVHIVNIPYDVTAEVGATVRLACGSTGSPKPTTRWTVNNVGLPPMDRFELLPTGDLIINGLRSTDGGTYTCTAANGISSESASATVTVQGAAVDPNCQDNVRYANCRVVLRANFCHRKPYDTYCCATCKDSQVRGRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRX6</accession>
    <name>A0A8B7YRX6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein jagged-1b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982133</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096033.1">
        <property type="nucleotide sequence ID" value="XM_022240341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRX6"/>
    <dbReference type="GeneID" id="110982133"/>
    <dbReference type="KEGG" id="aplc:110982133"/>
    <dbReference type="OMA" id="KVICLME"/>
    <dbReference type="OrthoDB" id="5989402at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000173">
        <property type="entry name" value="Neurogenic locus notch protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="9">
        <location>
            <begin position="34"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022096033.1"/>
        </source>
    </evidence>
    <sequence length="239" mass="27001" checksum="97349B5DC6C77A8C" modified="2022-01-19" version="1">MQESSAMAKPCAGFDFFWLLLLWVMVTFAFGHQCNPFHKTMYVAENRALQGFAYARMRVRSRAICGRDCRMDERCKSFNFNDNKMCELNLATRREHPGNFTATPGSVYYDEDEHTPRYSVNATNDFTDTGPCNSNPCKNGGTCREQLGNQGSFRCECAPGFKGTCCEDKPSDCRELYSRGIRQNAVYTIYPLTFSDGLEVYCDMEFALGGTPLLNSTGETSLPTTWTMMRIPILIVQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTB4</accession>
    <name>A0A8B7YTB4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022096529.1">
        <property type="nucleotide sequence ID" value="XM_022240837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTB4"/>
    <dbReference type="GeneID" id="110982448"/>
    <dbReference type="KEGG" id="aplc:110982448"/>
    <dbReference type="CTD" id="10535"/>
    <dbReference type="OMA" id="REECRFF"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="28"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022096529.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33410" checksum="29E53681983E3AF1" modified="2022-01-19" version="1">MDLSDFTKDNSKNAILKSIIPQVCKDEPCCLGIDEAGRGPVLGPMVYGVSFCPLSCKERLEQLGFADSKTLSEEQRDDLFSKIKEANDFLGFEVEILSPNYISTTMLRRTKYSLNAISMDSAIGLLRLAISQGANIKEVYVDTVGDAGKYQEKLQGLFPDLDITVTPKADAKFPIVSAASICAKVVRDQVLKTWAFLEGDDIVTGDYGSGYPSDPATKQWLADNLDKVFGYPQFVRFSWSTTSTLLENGAYLVHWEDEDEDESSKGTASLFSFFAPKNADPRDKQHAFFEERHLKRVESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUT7</accession>
    <name>A0A8B7YUT7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110982261</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096250.1">
        <property type="nucleotide sequence ID" value="XM_022240558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUT7"/>
    <dbReference type="GeneID" id="110982261"/>
    <dbReference type="KEGG" id="aplc:110982261"/>
    <dbReference type="OMA" id="LPFFDVH"/>
    <dbReference type="OrthoDB" id="10038482at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF74">
        <property type="entry name" value="PTB DOMAIN-CONTAINING ADAPTER PROTEIN CED-6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096250.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="38636" checksum="3DF3A99D313E975C" modified="2022-01-19" version="1">MAGLLGRKGKKKAQLELNNELPFFDVHYLGRSLTKTKMGRECTKNVVEDLVKKAHGRELQTVSLTISSRGIWVTEKSGQGNGRETFIPIYSVTYGAADKKYQNVFTIVTTYRPNGAINKSNRQDKDSGGSGSGDGSATGSANGSNCSGAPVNCKGNNVEDFKALKSVKASSSEVFVCHAFLCRDPVLARAMVVYLLKAFRVAFESWSRCIKSERLRERIKAGPGVTGASEQGKSGQAGRKNSHHELLTVEPLAKPPEETAPLVDKVAAWMDKWFHFGNNKKHSEIFSSEEPSSDPSEFEEFSKRMMEFSDPTLLNFDVDIEAELKDVEVCSALSEVVNREPPVSSSAAGSGGVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWJ5</accession>
    <name>A0A8B7YWJ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110982732</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097062.1">
        <property type="nucleotide sequence ID" value="XM_022241370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWJ5"/>
    <dbReference type="GeneID" id="110982732"/>
    <dbReference type="KEGG" id="aplc:110982732"/>
    <dbReference type="OrthoDB" id="10072098at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046616">
        <property type="entry name" value="DUF6729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47773:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47773">
        <property type="entry name" value="SI:DKEY-9I5.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20499">
        <property type="entry name" value="DUF6729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6729" evidence="2">
        <location>
            <begin position="126"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022097062.1"/>
        </source>
    </evidence>
    <sequence length="595" mass="67058" checksum="4766048E8D64EF20" modified="2022-01-19" version="1">FVLFCGNLEDVLQDSEVAVSTQITTVGKLLPSTLTSDDEPSTSQSALEERPVSPDLHVPATSGDESVLLEGWQKFWDEPPPQVQGMYSPNILWLKTDGPYGIFETPRTYTTANGEQAMRKVFKNKMDFNPPPLPTRVQGSLPSMLSFFTTPVFFWRPVGVLQVKLKCPNAKCPAPPGSYLSRSGYGNLARQVCGLRYTYTLLTERLKCSFCMQKRQQTTDEQQLQYRWHAYSPSLLANLAPAVRSMFPAILCGKRAVDKNVVTLLSDRLNSVSMAKVHRMIQQGHDEWYAERRDLYQTLLHQAHTAGNASGSQQGILQFIKPPGSYTAPIQQTPLPSPRVLRRAHLIMEMEKMPMYRASVLSVTGEILCIDGTKQILKKIYGDGRGTMQYVTSVLNEWGQFLTVVVVASESEDCYQQLARGLVSRFRRANAPAPKVLYADNNCCREGGTSWLESLFEAWVDKGLVIRLDIRHWLHRWDAVVIKQSHAKYGTFMSALAGAILAYNKDDMLLLIEAVRKGNEELYSQYTDEQMVSFVKPYQLKSYVRRVTRGIEVSCFHSVMFMFSIQQNDGCCQVVLVRNIASVGCYKLKGLECNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWX9</accession>
    <name>A0A8B7YWX9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ubiquitin-conjugating enzyme E2 variant 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110983141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097828.1">
        <property type="nucleotide sequence ID" value="XM_022242136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWX9"/>
    <dbReference type="GeneID" id="110983141"/>
    <dbReference type="KEGG" id="aplc:110983141"/>
    <dbReference type="OMA" id="GPESCSY"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034891296" evidence="2">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="29"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022097828.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="17990" checksum="E637C5537607B0A9" modified="2022-01-19" version="1">MWKFMFVCVAILGNLGVVSSSIRGAVTVPRNFRLLEELEEGQEGAGDGTISWGLANEDDKTLSDWTGMIIGPPGTPYEGRVYSLMLRCGQKYPDVPPSVRFITRINLTGVGAQGLVDDRFYFVLAKWQRSYTIKTVLTDIKRKMALQENRKLPQPPEGSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY71</accession>
    <name>A0A8B7YY71_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metabotropic glutamate receptor 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110983379</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022098288.1">
        <property type="nucleotide sequence ID" value="XM_022242596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY71"/>
    <dbReference type="GeneID" id="110983379"/>
    <dbReference type="KEGG" id="aplc:110983379"/>
    <dbReference type="OMA" id="NECPIRI"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034697805" evidence="11">
        <location>
            <begin position="20"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="547"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022098288.1"/>
        </source>
    </evidence>
    <sequence length="670" mass="73992" checksum="3D236A7B64E8576A" modified="2022-01-19" version="1">MALCVVLMLLVAAAKIAFTGTIPNAAHASVTRPGDVILGASFPIHRWSSGAPCSAGLYSWGMELSAIVMFAIEQINDREDLLPNVTIGYDIRDNCYSETLSLWTAFSLASTSERPQEDVQFPKISPPDNGSLLCIIGTQTSATTIPTAQAASLYRVPVISPFATSNELSDKRRFPYFLRTVPPDSLQASAIADILLQFQWKYIGLYFQLNTYGIHGAQSLLDLAEKYGICVAFSIAVRYQAKATELLDAVGRLSSFPKAKVVVMFMDSQTASEVLTTMSDGGLLSQLTFVGSDAWALPNSLKRHGVEVSLLQGSLFVQLRYTRIAGFDYDRFIQIVESSTPWLVEWKAEHNCSNLNECPIRIDTNDNFVVDAVYAFSYALHNMFYDRCNNSTNCNLPIKKFIGQDLLQYLRNVRFKGLAGNYSFDSNGDPSGNYKILNFQIVDGTVRAVEVGRWSASAADPLELNVSAVRWPETRGKPVSICREDCQSGFIAVPLEEKCCFGCQRCPDEAIVIDNKCRPCPMDEWPDENFKVCQPIVPTPPSWSEPTVVAILILSAFGLILSLLAAFGIYYYQGHVLIKAASRELSSINILGLTLAFLAPFPLLAQVTDASCRVSEIITTLCFTLTYAPALLKVNRIYRIFDAGKKSNKRPRFIGPRPQLLLAISVSLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYI0</accession>
    <name>A0A8B7YYI0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major surface trophozoite antigen 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097747.1">
        <property type="nucleotide sequence ID" value="XM_022242055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYI0"/>
    <dbReference type="GeneID" id="110983102"/>
    <dbReference type="KEGG" id="aplc:110983102"/>
    <dbReference type="OMA" id="TCLECTA"/>
    <dbReference type="OrthoDB" id="413581at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN,N-TERMINAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46967:SF2">
        <property type="entry name" value="SUSHI, VON WILLEBRAND FACTOR TYPE A, EGF AND PENTRAXIN DOMAIN-CONTAINING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="84"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="236"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022097747.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="49897" checksum="8E56109475C0C8EE" modified="2022-01-19" version="1">MAELVRSSRLLSIVWIIFISSLVQALIVQASMWFNLWNKAQFEQFNCTDFKINLCKACRPGTAANTSTEECFCCAEAQLHGECSDDGCYECGRGSYQPDPGQTICKMCPAGEYTDEEGSQLCKKCSLGHYSNITGAPGCKPCRPGSFANETGSRICRECPKGHSQKDSGQTKCTACTPGHFANVTRLPSCYLCQPGSFSNTTAASNCTKCALGYYQPKEGQASCKPCETGTEARRNGCAKCTNCPTGTYANVSGSAVCLPCPPGSSSDTTRTVNCTLCQAGTFQGLAGHSECLPCTKGTYCAKNGCTSCYNCPAGHESLKDRAKSCTPCDSGKYKPVASSHACTECRDGWYQNKTGQSTCIECPAGYFCPCKYCKPLECPPEAYCPKGSMTPKFLTCSPLFSKTPQNYCKPEASFYVVIGLLLVVAVVTLACVVRRLRHSRAKLEVEKSLLSSVSKDGAPIYAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZL2</accession>
    <name>A0A8B7YZL2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vesicle-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097945.1">
        <property type="nucleotide sequence ID" value="XM_022242253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZL2"/>
    <dbReference type="GeneID" id="110983197"/>
    <dbReference type="KEGG" id="aplc:110983197"/>
    <dbReference type="OMA" id="TYIAYSH"/>
    <dbReference type="OrthoDB" id="10658134at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022097945.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="62287" checksum="1DF046025BD4FD4E" modified="2022-01-19" version="1">MGNQESASASIHVEGSVSASGAVDAGVSAEGQAHGPPSPKKRRLSFKSLRNGSFRRSFKIRRSGRRKSPKGKGEERIEMEGDVSGEKGAAARAAAKLKASGEGKPVVDLNIAAPLATDETENMDLDADIEAGGNVGVSGGASGDLGGSAGLQADIPSGASAGVGVSGDMPSAGASLDVSAPDVKLNINGKKHKKRSSFPKFRKRTPAEAELDVELPKGEVQIGGGADVAAGINGHKGLKHGKRKEGPSVSAEGGASMDVDTPAVETPKVGVSGGADGDVNASLPSADVTVKADMPDAKRHSPKKGGFFAEIAKFFTGDSDSSDSDSDAETKNLKLQGSLHKGDVSGGAPGADISGGVGANLDASADISGSPEGEAKFNIGAGGKSSPSKRKKGGKFKLPKLGKRKINGNADAAVEVPNADLKGVVGFNVEPPDAVVKADVDTDVKTKKADFRFGGGVNGDGELDLKGGISGPDVSVSGPKASLGGDDGIGGDGDVNIGVNVPDASLGVGGDVKVPNIGGGIGGLGIKGGISGPDTDISGPTIGGDAGLGGGVNIPDASLGVGDVKVPSFGGGIGERGGLDIKGGISGPDGDASGPKIGGDAGIGGGVKVPDTSLGVPSFGGGIGKGGGLGIKGGISGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZS2</accession>
    <name>A0A8B7YZS2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-glucosylgalactosylhydroxylysine glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.107</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acid trehalase-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110983330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(5R)-5-O-[alpha-D-glucosyl-(1-&gt;2)-beta-D-galactosyl]-5-hydroxy-L-lysyl-[collagen] + H2O = (5R)-5-O-(beta-D-galactosyl)-5-hydroxy-L-lysyl-[collagen] + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:11068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12753"/>
            <dbReference type="Rhea" id="RHEA-COMP:12754"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:133443"/>
            <dbReference type="ChEBI" id="CHEBI:133452"/>
            <dbReference type="EC" id="3.2.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.107" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022098202.1">
        <property type="nucleotide sequence ID" value="XM_022242510.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098203.1">
        <property type="nucleotide sequence ID" value="XM_022242511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZS2"/>
    <dbReference type="GeneID" id="110983330"/>
    <dbReference type="KEGG" id="aplc:110983330"/>
    <dbReference type="CTD" id="80162"/>
    <dbReference type="OMA" id="PAMTYSM"/>
    <dbReference type="OrthoDB" id="200349at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047402">
        <property type="term" value="F:protein-glucosylgalactosylhydroxylysine glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000023">
        <property type="entry name" value="Protein-glucosylgalactosylhydroxylysine glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665632" description="Protein-glucosylgalactosylhydroxylysine glucosidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="10">
        <location>
            <begin position="337"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022098202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098203.1"/>
        </source>
    </evidence>
    <sequence length="733" mass="82163" checksum="CC28B7C8EBC96E60" modified="2022-01-19" version="1">MSLVIRSVVVILSLYCMIDQCHFHSAKRRTSTNMTNGCPCNQKYKDISLLPNVFESAELPTEACCLPAVGNGYLATVVYSDTIYVNGLYNGRGGASHRARIPSTAAIKISLPAKVNISKESYSLELENGTFHRKVRTDVAFIEQRIYAHQNVSYILVNEIVVTRTGQPTDPITLRLMNNTGIDSKDINFKMSASDDGSGLMYGNTVESETSTSSTIPIAVNWTIIPDTITLPSDQNTKTWTFITAIGPNSTVASLFQAYGSSLASAGMLYSNHYMEWQNKWNSGLMEVDNVTLSKAIYGSMYYILSSLPSINYDDQQFPFHFYGLSPGGLAHGRFDTDYEGHVFWDQETWMYPTMLMFHPKLGRTMLESRTYHLDAAKDLAKSRGYQGAEYPWEMAYTGAEVCPAEIYSLQEIHINGDISFAVQQYLHVTRDADFLKNRRGYEIISELAKYWASRVEYNSMSGNYEILGVKPPDEYHSNVNNSVYTNAVAQISLRLPAYAGKFINVTAPSSWAKIADKLLIVYDILHTYHPEYEGYNIGTKVKQADAILLGFPLNIKMDIDPRIVDLRTYAPVTDPDGPAMSWSMFSIGYGEIRESDKQDEMFQRNFKNIQQPFRIWTETASGSGAINFITGMGGFLQSVLFGYGGFRIHPDYLLFNFVLPQGTSKFTVRGLDYLGSEIDFIATEKTVLVTVTAQQHGAPNLRMETAEGVINDLVKGKTVMIHRLSWVTIRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z020</accession>
    <name>A0A8B7Z020_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110982581</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022096786.1">
        <property type="nucleotide sequence ID" value="XM_022241094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z020"/>
    <dbReference type="GeneID" id="110982581"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000005">
        <property type="entry name" value="NAD(P)H-hydrate epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="12">
        <location>
            <begin position="109"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="13">
        <location>
            <begin position="243"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022096786.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33284" checksum="EE96B55FD56B1DE5" modified="2022-01-19" version="1">MSCVVCRCSVVSIRAAHVSGRVGSLHRTCTAVPLGDIPVRSRLYSSRDETWDGDSVMSGIISSPNGIDVAGMRKAYKAGHEAFTEDELVSKEPIGQFAAWFKVASEQDSIGEANAMTLATASKEGRPSARMVLLKGYDKEGFKFYTNYESRKGKELIDNPHAALCFYWEILSRSVRIEGPVERLTEEESTKYFHSRPPTSQIGAVVSHQSTVIESRDVLTSKDNELKEKYLSTGLAIPKPNYWWGFRVIPEVVEFWQGQSNRLHDRVVFRRLKPGETADGTFVHEGENGWVYERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2U9</accession>
    <name>A0A8B7Z2U9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger CCHC domain-containing protein 10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099100.1">
        <property type="nucleotide sequence ID" value="XM_022243408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2U9"/>
    <dbReference type="GeneID" id="110983828"/>
    <dbReference type="KEGG" id="aplc:110983828"/>
    <dbReference type="OMA" id="SRTMQFK"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022099100.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="17790" checksum="23F691E6B8FA9888" modified="2022-01-19" version="1">MATHMALMKAKNNQNKENVRCQKCLEFGHWTYECSGKRKYVQRTSRMSHLNKKIKQAKEQAETQLVPKTDGKPAHAKSKKSKRRKASSSSSSSSSDEDSSEDSDSSDTDSDSSDSSSSDSSDASDSDSSDSSSTITSSSGSTSSSSTSDSDRGKKIPRKKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4W1</accession>
    <name>A0A8B7Z4W1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Ankyrin repeat domain-containing protein 6-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110984619</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100672.1">
        <property type="nucleotide sequence ID" value="XM_022244980.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100673.1">
        <property type="nucleotide sequence ID" value="XM_022244981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4W1"/>
    <dbReference type="GeneID" id="110984619"/>
    <dbReference type="OMA" id="HNETTRI"/>
    <dbReference type="OrthoDB" id="424503at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="558"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="740"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="802"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="912"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="803"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="846"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022100672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022100673.1"/>
        </source>
    </evidence>
    <sequence length="972" mass="107992" checksum="41803C1BB67C49EF" modified="2022-01-19" version="1">MAQQTAQLSERLRLAASKGEVSYIRELVQSGAGFTADKYGRTALHYAANYGQAEAVKLCVHLGCDLDAQDVYGCTALHRAAIDNHTDAVRALLLEGCAVDRQDENGNTALHEATWTGYDEIVVALVKQGKANLHASNKYGNKPLHQSCQNGHSETTRILLRAGSHPNIKNNNGETALHIAALFGHITCCRILVSANSNVNITNSEGNTALHVAAGLGKKKISKILIEASTDLSISNNNGETALEIARKNDHADVVMLILAAIKLQKSKSSNHHHHHHHNKTPHKPPAAGQDRPEATQQHHRHKQDAEVADASKPDEARVRGRRELREQERKESQERAAASHQHKKDGEERKKKSGKPSALAKKPILATNQSQRTTSHKQVTFVKEELRNAVLWEKQLHQQIHSVKFEDVDGKGHHHRHKHHQKCLYKDDKGNVTKGTTTSYCTCSIYIHKLQNQLEASKEKMLYEIDTTRAQFEHQLVSLDKKLTHQGSCLDQLCKERVASEHTECLHRIDRRILQERALWSEEYERRLSYVREELRRYFEVRLRTVQQQLAVYYPSDERQPLHGNPSGFERISEGTEDSSGSDPNTRQRVKAEIVGPSGRMIARRRPSPNPGHSTRVASADGRLTHSNHPRQNGILNHHVNGEQSHDAYQSNYTEDNRGRSRMVMRGPPPRGRRTSSFTRAVQHQNASASPGHPKDDHSGKELVSATYIPPIAHPDLPQSSKPREPESAVVAASFNFKTDSSGEESSSSSTISLKTVSRRPVRANHSDTQVQGSECTSEAPHASDNRPFQRLSKIALEQKAQFESQQGHHTKASGHSQEAVRQQPVSASSWQKSAYRIPADVTAQSLPSNPQSNQTSPDSNSPSSSQYSPNQCGYSNSSSGVSSGDAATASSIRTRRNPIDDVLIRAFAMERERQTMRKSNNRPGTARADFPKSTEDSKPSAYVKGFARADLSQSDSLQVTPSRKTHELQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5C3</accession>
    <name>A0A8B7Z5C3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">5'-3' exoribonuclease 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110984281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099990.1">
        <property type="nucleotide sequence ID" value="XM_022244298.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110984281"/>
    <dbReference type="KEGG" id="aplc:110984281"/>
    <dbReference type="OMA" id="VYACPLM"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="669"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="869"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1116"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1465"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1569"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1732"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1928"/>
            <end position="1968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1988"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2025"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2060"/>
            <end position="2107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1271"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1314"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1329"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1361"/>
            <end position="1384"/>
        </location>
    </feature>
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        <location>
            <begin position="1401"/>
            <end position="1417"/>
        </location>
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        <location>
            <begin position="1429"/>
            <end position="1444"/>
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    </feature>
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        <location>
            <begin position="1479"/>
            <end position="1491"/>
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        <location>
            <begin position="1569"/>
            <end position="1580"/>
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        <location>
            <begin position="1759"/>
            <end position="1776"/>
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            <begin position="1780"/>
            <end position="1793"/>
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            <begin position="1928"/>
            <end position="1945"/>
        </location>
    </feature>
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        <location>
            <begin position="2002"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="2029"/>
            <end position="2040"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022839"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF03159"/>
        </source>
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            <dbReference type="Pfam" id="PF18129"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF18334"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="2107" mass="234357" checksum="6343C15210A1ACBD" modified="2022-01-19" version="1">MCNLFALRTYIYIRVLLIAEKSLTNVASVRKDNCFQISVHKMGVPKFYRWISERYPCLSEVVKENQIPEFDNLYLDMNGIIHPCSHPNDEDVHFRITEEQIFEAIFHYIEVLFRIIKPRKVFFMAVDGVAPRAKMNQQRGRRFRSAREAEERERQALAKGETLPAEKRFDSNCITPGTPFMVRLQEQLKYFVRQKLTKDPMWQGLTVYLSGHETPGEGEHKIMDFIRSEKVRKDYDPNTRHCLYGLDADLIILGLISHEPHFSLLREEVRFGKIANQKRPTAPEETTFHLLHLSLMREYLEIEFSALKPQIDWFDVECIIDDWVLMGYLVGNDFIPHLPDMHISHNALPMLFKAYIEILPSLGGYINEHGTLNLPRFEKYLVHLSKFDREKFEETFSDLSFFAGKTDIRAWKSSRVEAKKEKEKERRAAKANSNQYALLDNFDEVMGLKLASGSEVAGQSPDSSQDADSSDQEDGDTFEEEFKAHKSAYYNSKFEIDNITEFYPYHYAPYMSDLQGISNLDLKYEKGEPFLPFQQLLGVLPAASKDLLPEPYQKLMTMENSPIIDYYPLDFDTDLNGKLQQWEAVVLIPFIDEERLLAAMDSVSMHLTDEERSRNQHGPHLKHTYDKTLNYKYLSSLPGHFPDINACRVRYEELDKDIFHLDPSMLQRGLRPGVKTGVYFPGFPTLHHLKFRTKLSKEEIKVFQQNSRGESIILTIKTENADVTAEDVISEVFGKSCFAEWPHLKEVKVVAVADDTTRFELAESKQRSDQQAEKPSVKKLDMSDGDAAAWVKDIKAIQDRYHKRKGVKIGPSYVLVYACPLMGRRYVSGHSGVVTLEKQWSDTPVAYAYQMMVKDIAVHDSTFQQFKTLEEVFPKQSNCFMLGAPNYGCQGSVVDVEDGRVRVTLSCPVEPDLNHLRNSQSHYEIQYLPAHILAQRLGLTSLIISRLSGSIFVGRGSKHSSSVGASNNFNIGLNLKFNKTNQEIQGYSKKDESGTWLYSTKVIDIIRDYMAKFPEVFLRISKNPRAEAFFEDDLFDGQPGRMKELQDFIKALPCAKVSKVDVGLKNLDEPIIKLIEAEVKKVAGLKVRKQKLCVRPHLLYKPLHYMGNLIPDLQVEHELFDRVINVKEGHTVPLGVRGVIIGIQPGDTVLDCIYEIVFDEEFPGGLVIRCTGNRGYRLPTTAIINISYGMRKEQGQQQSNKPTAVVKPQVFPQPNARTQSRGWYSDIIGRLGASLEQSCQSQRQKQQQRQSHTQVQSKPTAAINYKEALSQKGSVKQETEQSSNSQASLPMKILTRSGPKVTARSPSKEPLPGKSSQSQRIPPSFQKQEGTDSRKNTAKTEKVGQGQRKDAVSKSEVSTTRIRDKALSEEIRKIRSREDKKAAEPEQSPANEVDEFAIMWQNLQKGSNNSGTSSPMTEDSAPDKESSPSDELTSPLASGGQTPLSEEDMTGPSVQMQLALSALPKMEAPGPKVTGGETIVEEGDEEFEGEEFEVDEEARMTPRTYAKSGTEELCRMLNISSVSDGDGTTKDIALPHSVVIEASTGKKQYGIPLTLDQLFAGASLNNPPNSISPAPITPTSQASVPVPGGGSQPTPLHPHPLAQVSGPHPGLMKGPESSHPGTVPTQPRPLPQAPGHATIPVKVGSHGVTFQPAYFPQGAVSPARLTVGNYSPQSGASPVQLLPHHTFQGTPLVTVNPGKPGMQHPASLMVQPVGQTPQQQLGVQQQAQQPIRMQGPGHQSQAGVVKPVPTHADPHSPAYPQQQPTSVSANENTSNARLYPASAPQQQSASVAQGHTPGFHVVTPRPFQTAPVPIAAPGRSHPGPQVMGSPSQPPNLRPRVPFPGQQHGQPPPQGFPARPQNAFEALLMWCHQRGLPQPLCHYQRNNTTGQVRGMVQLANGQQFFGPDCPSDVIAVDAAAHMAMTNLTSQSPRSPMMQQMRPTTRPTLGPMGPPSGPMIHTSGPNPFVPLQVTKQLNSPQRLTSIEAEATSGTTPPRQQMEYPAQAPPSQGAPPSSRVDLAATDQSGIKDNSHQSSRRELDFGSSTVNTVAHSTEVVASVEHRKPSIDETLGAVHSERRASTGGPARHRRVSSKAKLAINFGGKPEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z676</accession>
    <name>A0A8B7Z676_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110984866</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101139.1">
        <property type="nucleotide sequence ID" value="XM_022245447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z676"/>
    <dbReference type="GeneID" id="110984866"/>
    <dbReference type="KEGG" id="aplc:110984866"/>
    <dbReference type="OMA" id="AQLWIME"/>
    <dbReference type="OrthoDB" id="10185238at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KH_dom"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="345"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="432"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101139.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="61057" checksum="D74026AB5272FC9E" modified="2022-01-19" version="1">MLTGPLFEPETVPQTMAPNLWRPTYGSYFTYDAPPSESNKTHSCPAKLVGPMYGRYASRPPLFELDRTSRPAVPNQWMPTCGVLSLYDVPPVESNKTSCPAVLTGPLYGQHDSLRPHLFRPITMPTPTAANPMQFNSVCSVPPTQFNDTSGCLVEQMGPPHGPSGTVVPTIGLLTVIPAHQEAVDLVSLRPPNTAPPSTSDRPPIRVMLPSRPSLIIQVLCAGVGFCCTRDVIAVLSAVISAWGGMTRKIKAAFSRLKNWIVAGTKMIHWPQQSHQHYFESFSPWVISTVTKVVRSSPVEAPVTVIFPPPRWCLAKNKPKQEDEHDETNSPEDISENDISDVGETKEVLIFKVKNGSFGRIIGKKGSIVKAMRNDFNLVIMYGRLDERHYFFKLEGKSSGVKSARALCYQRVQSGLEEIQPMDIAHRVSPENIISVKYSYFPWHHGRIVGKQARCLKEIRASNVAVWVNFGEEFHHMELTGTPSNVRKAQLWIMENLNATLFANMPDLVEAPDVQLPSQAGEDQGATAEAAGPEPEAVCGVCSWNWAQASSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6K6</accession>
    <name>A0A8B7Z6K6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Octapeptide-repeat protein T2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC110984577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100592.1">
        <property type="nucleotide sequence ID" value="XM_022244900.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100593.1">
        <property type="nucleotide sequence ID" value="XM_022244901.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100595.1">
        <property type="nucleotide sequence ID" value="XM_022244903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6K6"/>
    <dbReference type="GeneID" id="110984577"/>
    <dbReference type="KEGG" id="aplc:110984577"/>
    <dbReference type="OMA" id="AMRHEAK"/>
    <dbReference type="OrthoDB" id="9931375at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029094">
        <property type="entry name" value="Draxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28610">
        <property type="entry name" value="DRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28610:SF1">
        <property type="entry name" value="DRAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15550">
        <property type="entry name" value="Draxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665665" evidence="6">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022100592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022100593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022100595.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30573" checksum="71B1B0E5E2C1CE27" modified="2022-01-19" version="1">MRIFVALFVILIAVLVLAEIGEAKKKKEPHRSEAEAAEDAGRHRGNRQREKERRGKKNRGRQNGEQTDGDVADQDDATADTEAMEPEEPQEVPEAQPQEESSAPRRGKKRQRGEGKGGAEPDKTARRAAKEERLQKRLEKQAEKEARKEGRATRKEARKEAKRESKQAANAERKQARKEAKKIQRQNMTSDCTEHTECPAGSCCQHRGAVQKCRVFNKPEGSRCFADCVCAEGLECFIREGKQSKHPDGSAKGRCRMVGDEPTNEEQAQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8C4</accession>
    <name>A0A8B7Z8C4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">Glucocorticoid receptor-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16" type="primary">LOC110984821</name>
    </gene>
    <organism evidence="13 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101053.1">
        <property type="nucleotide sequence ID" value="XM_022245361.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101054.1">
        <property type="nucleotide sequence ID" value="XM_022245362.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101055.1">
        <property type="nucleotide sequence ID" value="XM_022245363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8C4"/>
    <dbReference type="GeneID" id="110984821"/>
    <dbReference type="KEGG" id="aplc:110984821"/>
    <dbReference type="OMA" id="LGKETIC"/>
    <dbReference type="OrthoDB" id="5984981at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000006">
        <property type="entry name" value="Nuclear receptor subfamily 5 group A member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016355">
        <property type="entry name" value="NR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086:SF25">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR FTZ-F1 BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24086">
        <property type="entry name" value="NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="11">
        <location>
            <begin position="553"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="12">
        <location>
            <begin position="713"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="652"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022101053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022101054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022101055.1"/>
        </source>
    </evidence>
    <sequence length="947" mass="103581" checksum="D910464FC907AA0B" modified="2022-01-19" version="1">MTEERLFSGTPSTSSYLYEQIHVPGNLGTDCVPSHRTATGRCRADAEGLQLPHRMYQLIQTIESPNQQGSQITSTVAAASHVIPPRGTYMYAGGLLPALSHRDCSTSISDALPPLPIKQAPANLSSNSFSCTPPISQFAFNSIPWNVTQEAIPLLVSSSSPLHDDITRQTSSAIKQEMPASDARQVYSSLLDAKIRAHFSELCKLQHLQNLLNQHATQQKSSLAQPAIGTISTQSHQPLDLTSSGVTNSKSWLVTSAEKIETNQGLMSVTMAASANHPSTVVAVDSNLKTIPSVPGMSHKNGRSTCTSSTESIVENIVSDTYAEAKLCKSLSLSPVMQRDTKVFLGETALPQDLFTLPDAFSRHSNSFNLLKPSNLNPQSQFSVETKTDRPGLPLAYADQEKTSPLESVGVLKVLCKASSEGVGSSGQIVSEDMPSPLAGVGSGLQRDVDTMMGPVSALGGSESTSEEVHQSLNLQLYEESLTTVPSSPQPDFSPAPLVDMIQDIPPLAHTSLTSDPVSAETNAVALQDQGQSLQSQTNTAQTVDFTEQLPRDKKCPICEDKVSGYHYGMYSCESCKGFFKRTIHSKRHEKLKCALGGGCKVDLQSRKHCAACRFQKCLSLGMKLQAIRQDRQRGGRSLYEGSSEQRRLIKLKQEQEAKASPTPKKRRHRQPSKIPSDASTAIAGSRSGQTSVAPLRKSEPSRGGPVQEAQLRAQQLIQELQEQEQVFVKQSVADCCLSTLREEKNLVETICHFVNHEILPLVRWAKGLPMYRELMIEDQIQLLYKCTLSILCLNLIFYCLDNAGHLLLPKNQVIDLTTIHTAKFHQLVPKIKRIADQLHSVGLDMSRFVFLKLILLLSSDTPLLHSSEQVQSYQDTVQEALFDHVTRTQLGSSLTVGNLMLGLASIERIAQQLGKETICDLAVVDNVFRHDTDVSSDRPYIQVKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8E1</accession>
    <name>A0A8B7Z8E1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Contactin-associated protein-like 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110984906</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101227.1">
        <property type="nucleotide sequence ID" value="XM_022245535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8E1"/>
    <dbReference type="GeneID" id="110984906"/>
    <dbReference type="KEGG" id="aplc:110984906"/>
    <dbReference type="OMA" id="HICSAHP"/>
    <dbReference type="OrthoDB" id="6071166at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050633">
        <property type="entry name" value="Neuropilin_MCO_CoagFactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46806:SF5">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034804663" evidence="14">
        <location>
            <begin position="37"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="15">
        <location>
            <begin position="59"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="215"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022101227.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="32710" checksum="90D6790E88EA4880" modified="2022-01-19" version="1">MYFLLPSTMAFARGSQATLALTATLNFIASLQCCWAHPVREAVTSQDYSRTSHISGISCFSGPLGMASGAIPDSSLTASGSYSSRFLPSNARLNGSTWWACPKGKVDSQWIQVDLGHYTAVTGVILHGHGSHHIHTFAINFSSTVNAGDWHELTDKGRTLQLNAINGAGQPVMNVKFPVVLLARFLRIIPLTWTQYDHYYLKFEVLGCRVSNGTIRLVGSDDKWSGQVEIYRHGAWGAVCDTSWDMKDATTVCNQLGFIGVLEAKTGLSSRESDRPIVMNRVTCNGTERQPSFRSVPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8E6</accession>
    <name>A0A8B7Z8E6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: aristaless-related homeobox protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110985303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101934.1">
        <property type="nucleotide sequence ID" value="XM_022246242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8E6"/>
    <dbReference type="GeneID" id="110985303"/>
    <dbReference type="KEGG" id="aplc:110985303"/>
    <dbReference type="OMA" id="CTIRKDI"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000102">
        <property type="entry name" value="Aristaless related homeobox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF337">
        <property type="entry name" value="ARISTALESS RELATED HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="77"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="9">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="79"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022101934.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33626" checksum="A87A6C22235B5204" modified="2022-01-19" version="1">MDRLAKTERWRPFGARSITLSLLTQTHTSHPDAEVVYGKDGGHNGIRFSATDHHYSASPPGLQGYDCQPEPGITAKRKQRRYRTTFNADQLKELERAFCKTHYPDVFTREDLAMRVDLTEARVQVWFQNRRAKWRKREKQGVRQAPPICGYPAEHAVPSPTPHLFLQPHLYFPVNAFQTPTESPGMAAAALLAGLPKQVHYPFLHPGLASSRAGVLPFGVHPPRPSVWCPAVPVIPRVKSAERLATHSDIRNCLVPKHAAEMQPDRLSFSIASLRLKARQHEVNTCMERGENVSLADTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9X2</accession>
    <name>A0A8B7Z9X2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110985625</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110985625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102464.1">
        <property type="nucleotide sequence ID" value="XM_022246772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9X2"/>
    <dbReference type="GeneID" id="110985625"/>
    <dbReference type="KEGG" id="aplc:110985625"/>
    <dbReference type="OMA" id="KPGFQHE"/>
    <dbReference type="OrthoDB" id="8960773at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="282"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022102464.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="57280" checksum="76DBA58D371FC15E" modified="2022-01-19" version="1">MASRLVNSLVESSGQKCLQIIQLPLVIFIFCLCLTMSIKLSAAQTVDTTEVNTTTETDFLTDNLTDIVTEFVDNEPGTTLSTTVETVEEYTAEETTQELTTESDLVTETVTDTLDNETGTVLNTTVDTLEELTTEESTPELITDLPGSTFVIRFNISNKDYDNIKNQTEREELERLLVQEFKELFIGNKKLKSVTVSELRNGSIIADVKLEFKEVLNIKEREEVIMTLFEQVVLNGTLGAFEVEDLKLVSGNGEVMELNNACDVRPCLQTEMKCMASGIKCTASCSDNKGYCLNNSTCQESNDYIQCKCKKGFFGYRCDKKPLPPSGGRDDNAYIGIIAAAGIAVVLLLVMIIGCGYNRLVNRGKECDTSKLFPAENSVALEMLDEPPPVVGGVACQTIESFLLTKYMKHGVPPKPGFQHEIVQTNESFLLAKAQREREAAVNNVPASSTQSGNGASPPPTSAPTPVGSTEQDCKTEQEKQPSTEPKQGISNKAFVEDECDIVPTAEVTGEEAKADIGKKIIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAK6</accession>
    <name>A0A8B7ZAK6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Polycomb group protein Pc-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110985256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101850.1">
        <property type="nucleotide sequence ID" value="XM_022246158.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101851.1">
        <property type="nucleotide sequence ID" value="XM_022246159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAK6"/>
    <dbReference type="GeneID" id="110985256"/>
    <dbReference type="KEGG" id="aplc:110985256"/>
    <dbReference type="OMA" id="YRSDWTW"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033773">
        <property type="entry name" value="CBX7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017984">
        <property type="entry name" value="Chromo_dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052458">
        <property type="entry name" value="PcG_PRC1-like_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46389:SF3">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17218">
        <property type="entry name" value="CBX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00504">
        <property type="entry name" value="CHROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="43"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022101850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022101851.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="45951" checksum="447BF632101079D9" modified="2022-01-19" version="1">MYSPRTGVTEDPVQLDRHPMNRDIPASPVGVREGWDEVRNDVYIVEALKGKRKRKGKAEYLVKWKGWSNKHNTWEPEDNILDKRLLEIYSTRRPSVTSRRGRRPRRQISQPSSMFLSDLPYDWPNSEFPSRFRLVKDPNNGTWCTRHLAATADTSPTGESSQFLVGRQRNETSGTAGFASRTSYSRSASAPSTSCSGLDTGTINPRDDRSDWTWSPNSDRSQASLNASESGDKDGCTVTERDLTSFHVDEVPEFRLNGSSSQQGLGLKLSPKLVLRRITPPQTLRRHMTQEKDDSDTDEAHFSDPDEIKYYPKNSKGLAISLPPDAQGQSSREHCHDDKNDPETKTRPRFPPVNKEAISLPASPTAFDASMPQRVKRSEGVVVTDVTAGGITITIRESGNADGFFGNKIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCP3</accession>
    <name>A0A8B7ZCP3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985704</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102610.1">
        <property type="nucleotide sequence ID" value="XM_022246918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCP3"/>
    <dbReference type="GeneID" id="110985704"/>
    <dbReference type="KEGG" id="aplc:110985704"/>
    <dbReference type="OMA" id="YMCGWPN"/>
    <dbReference type="OrthoDB" id="6082640at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034697137" evidence="1">
        <location>
            <begin position="25"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102610.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20351" checksum="59CB17E41BCD7643" modified="2022-01-19" version="1">MNRSRVVLFFSATFLLVLVHGAHGCRRLGTSGSIPPKGQGPTQDPISDVWLGRLPFFSYMCGWPNDTVKGGMVRRQVIDPFQLIPRNLDPIHTLVYFRGEVYEWGQGLLRSYARGTLGRDPHGCPIHWSLYGQSNCTSSEVKEVAASYLSHYGSYNLLSNNCHSFTERLNQKLLSGDCRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDF2</accession>
    <name>A0A8B7ZDF2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110984905</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110984905</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101226.1">
        <property type="nucleotide sequence ID" value="XM_022245534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDF2"/>
    <dbReference type="GeneID" id="110984905"/>
    <dbReference type="KEGG" id="aplc:110984905"/>
    <dbReference type="OMA" id="SHENDLW"/>
    <dbReference type="OrthoDB" id="775972at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000063">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF13">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="8">
        <location>
            <begin position="500"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022101226.1"/>
        </source>
    </evidence>
    <sequence length="675" mass="76993" checksum="B71A7DCA4A3519D0" modified="2022-01-19" version="1">MLRDRLVVGCREPAIQRKLLSDTSLTFEKALNIATAMEMASKDVEKIKEISQPESQPADPKVNKMQFSLKPKPKFARKPPSSAKGKRQSDDSAKAASRSFNQQKYILMCRPYLDDIIISGRNDAEHLANLNIVLLCLKESGMKLKREKCEFLCDSVTYLGHKLNQEGLRPLKSKIEAIQQAPSPKNQEELQTYLGLLGYYRKFIPNLSRHIAPLTELLRAEFKTDKKTRKCHGGLMEDPKFMWGPRQEDAFQESKTLLQSDTVLVHFDPEKPLLLQTDASSYGLGAVISHVLPDGSERPISFASRTLTSSEKNYAQYEKEGLGIIFWLKKFHKYLQGRHFSIVTDHEPLVALFGDKKSSSPMASARTTRWHMILSAYEYDIIHKEDKKHQNADALSRLPVTGGGEAWCSEEMPRKKSRLEDGVILRGRRVVIPEQSALRLRLLREIHATHPGIVKMKALAHSFMWWPVIDRMIEHEVQSCQNCQEHQKMPPPTILHPWEFPDKPWCRLHLDYASISGKDVLIVVDAFSKWIEAIRVGNSTAATTVRVLQRLFSTHGIPETVITDNRTQFVSEELSQFLSQNGVEHLQTAPKHPSSNGLAERAVQTVKVGVKKIRSGDLELRLQQFLLCYRVTPQLTTGKSPSELLYRRQIRTKLNQLKPNFGRRVKIQQARMQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEB9</accession>
    <name>A0A8B7ZEB9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorting nexin-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104008.1">
        <property type="nucleotide sequence ID" value="XM_022248316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEB9"/>
    <dbReference type="GeneID" id="110986447"/>
    <dbReference type="KEGG" id="aplc:110986447"/>
    <dbReference type="OMA" id="VQWCEKQ"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850">
        <property type="entry name" value="SORTING NEXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45850:SF2">
        <property type="entry name" value="SORTING NEXIN-5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022104008.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43103" checksum="AE9091C5F8AA4CE5" modified="2022-01-19" version="1">MEEVTEQNGEATNDAPFEPWYQVQVTGATKNGSTIIFDVVTKKLEEGGQEATVQRVYEDVEWLHHCLMTDTDTSGIIMPPLPVRPLASAADAAAKAKRELGSDATVKGDEFYKHCRSLEKYLQLVIRHNFLGKNESLGKFLTEPEPPVRAKLKNSFLTNLTKVVGEVRKGGHQDLDPSFQKERSTVNEMVKIMTDSSLHFNNMLNVSERFSASLNNLSTALCLASTAAEEGPVSDLNKLQLHFAKAVEHYSHGIDIFVANDEQTLGFCLDHYAKYLDSEKSMLFIRTCKLLEYENASKSLEKAKPLKKEAAEELKEKREKEFNAISEIARKEITKFHRQRVVEFQKALILYAEAKIKTARDISALLAKDLSTLKQMELSDGSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF40</accession>
    <name>A0A8B7ZF40_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myosin-10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110986128</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103465.1">
        <property type="nucleotide sequence ID" value="XM_022247773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZF40"/>
    <dbReference type="GeneID" id="110986128"/>
    <dbReference type="KEGG" id="aplc:110986128"/>
    <dbReference type="OMA" id="NIDTCIL"/>
    <dbReference type="OrthoDB" id="10055605at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="12">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="80"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="173"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022103465.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29288" checksum="C0C47D3E337EA201" modified="2022-01-19" version="1">MAAAELKYLIVDKDLVSDPATQAEWTSKRLVWVPDETHGFVAASIKSEKGEDITVEVAENNKTRVVNKDDIQRMNPPKFNKVEDMAELTCLNEASVLNNLKERYYSGLIYTYSGLFCVVVNPYKRLPIYSEKVIELYRGKKRHEVPPHVFAITDAAFYSMLQDREDQSILCTGESGAGKTENTKKVIQYLAYIAARKEGKGASASQLQPSPVRKDLSRQNNRSQIHVSDLQKVSPRKRLVKTFSSTFNIMSGHPTYVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF95</accession>
    <name>A0A8B7ZF95_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proto-oncogene c-Rel-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103667.1">
        <property type="nucleotide sequence ID" value="XM_022247975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZF95"/>
    <dbReference type="GeneID" id="110986245"/>
    <dbReference type="KEGG" id="aplc:110986245"/>
    <dbReference type="OMA" id="PDIREPA"/>
    <dbReference type="OrthoDB" id="7881762at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007249">
        <property type="term" value="P:canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038061">
        <property type="term" value="P:non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034097">
        <property type="term" value="P:response to cytokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01177">
        <property type="entry name" value="IPT_NFkappaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07827">
        <property type="entry name" value="RHD-n"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000046">
        <property type="entry name" value="Nuclear factor NF-kappa-B p105 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033926">
        <property type="entry name" value="IPT_NFkappaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030492">
        <property type="entry name" value="RHD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169:SF25">
        <property type="entry name" value="DORSAL-RELATED IMMUNITY FACTOR DIF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00057">
        <property type="entry name" value="NFKBTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01204">
        <property type="entry name" value="REL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHD" evidence="2">
        <location>
            <begin position="71"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022103667.1"/>
        </source>
    </evidence>
    <sequence length="690" mass="75993" checksum="EA90799C926F5000" modified="2022-01-19" version="1">MTDRRAQLQEDESMQSTGSSGASLSLEHIEPGLLRAAAPSSESSKPSTSTKGGLDMNFLDSILITGSNDFSTEPVLEITEQPKQKDLRFRYECEGRSAGSLLGVKSNSDRKTYPTVKIKNYVGKAKIVVSLVTRQAPHQLHPNGLVGKPCKNGICTIMVENNQRMTVSFPNLGIQCAKKKDIQAAINERQRLGVDPFNESAGRANAQLPNDYEMNIVCLCFQAFLPDPNQPSQFTRALPPQVSQPIYDKKGASLNISRVDRNNGTVAGGEEMFILCDKVQKDDIEVVFFHDDWESHATFGPSDIHRQVAIVCKTPPYEDQNIQQPITVQFKLRRKSDKETSDPLEFIYRPIDIDADGVEAKRRKKAPHFHRFFKEPSSVKQEPFDPTQPSGSVIHQQLHVHQQQLHLQQLGPPNIARASADQDVRQILRNKLEQSSKQSHRQDLEVEQLPRVFARAVRTAASGNPKIAKFSKDSSTFSYSDSSNLSSGTVIQRGTPATATTGAPLTLPQDSVANCGTVLPFQGITVDATQGVTVEISDQVLAYQLQSNSDLTNMASTSDFGQNTPAQAFGQGTSGSEGTIPYLNPEEKLLQQLLEEENLAHLLVEQNINIEDLNPPNLEDLTTLQDFDPATLSLTNDGTDGMEVDQGLNNFTLENNVNDSVSIPYSHSVELPIENDSQVHNFNGNCDQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFR3</accession>
    <name>A0A8B7ZFR3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110985394</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102076.1">
        <property type="nucleotide sequence ID" value="XM_022246384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFR3"/>
    <dbReference type="GeneID" id="110985394"/>
    <dbReference type="KEGG" id="aplc:110985394"/>
    <dbReference type="OMA" id="CACAEYL"/>
    <dbReference type="OrthoDB" id="10048650at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055469">
        <property type="entry name" value="DUF7041"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327">
        <property type="entry name" value="ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33327:SF3">
        <property type="entry name" value="RNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23055">
        <property type="entry name" value="DUF7041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7041" evidence="2">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102076.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32632" checksum="976173EBB153495A" modified="2022-01-19" version="1">MMATPPEVVAPLSAVSLKLPPFWPHDPTIWFAQVDAQFQTRQITTQATKFAYVVSSLQPEIAQEVRDLLISPPTVDQYDKLKMELIKRTSESEQKRLHQLLISEELGDRKPSQLLRRMKQLLGENTLEERILRQLFLQRLPQNVQLILASSSDTVDLEQLAIIADKILEVASPPTVVTSTTVNAVSSSKSLEKRIDELQSQVSDLTTLVHELVMKGTSKGKRDFSRGRSRERTKNKSIDDRRSPSKSKSVPRAGSDCWYHWRFGDKATKCVKPCSYSETKSKATNQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFV8</accession>
    <name>A0A8B7ZFV8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110986692</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="16">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="18"/>
    <dbReference type="RefSeq" id="XP_022104489.1">
        <property type="nucleotide sequence ID" value="XM_022248797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFV8"/>
    <dbReference type="GeneID" id="110986692"/>
    <dbReference type="KEGG" id="aplc:110986692"/>
    <dbReference type="CTD" id="6389"/>
    <dbReference type="OMA" id="PTGIWRM"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 16 18" id="KW-0274">FAD</keyword>
    <keyword evidence="6 16 18" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 18" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <keyword evidence="5 18" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="19">
        <location>
            <begin position="62"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="20">
        <location>
            <begin position="511"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="67"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="455"/>
            <end position="456"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="17">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022104489.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="72638" checksum="5C58E6BAFCB8B083" modified="2022-01-19" version="1">MATILKLPCRSGVSLLGRLTKPATSSLGARPFHFTVEGRQTGGTAKTGSISHDYPVVDHTFDAVVVGAGGAGLRAAFGLAQEGFRTACVSKLFPTRSHTVAAQGGINAALGNMEPDNWRWHMYDTVKGSDWLGDQDAIHYMTEEAPKAVIELENYGMPFSRTEEGKIYQRAFGGQSYDYGKGGQAHRCCAVADRTGHSLLHTLYGQSLRYDCEYFIEYFALDLIMEDGVCQGISTLCLEDGTIHRIRAKNTILATGGYGRAYFSCTSAHTCTGDGTAMITRAGIANQDMEFVQFHPTGIYGAGCLITEGCRGEGAILINSEGERFMERYAPTAKDLASRDVVSRSMTIEIREGRGVGPLKDHVFLQLSHLPPQQLATRLPGISETAQIFAGVDVTRDPVPVLPTVHYNMGGIPTNYKGQVIVYENEEDKVVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACAHTIIEQNQPGEAMPELKPNAGEASVANIDKLRFADGNTKVADIRLNMQKIMQNNAAVFRTGETLKEGVDLIMDSYKTMEDMKLYDRGIVWNTDLIEALELQNLMINSVQTMVAAEARKESRGAHAREDYKSRIDEYDYSKPLEGQTPKPFEEHWRKHTLSDMNVESGKVDLLYRPVIDKTLNQEDCSTVPPAVRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZG88</accession>
    <name>A0A8B7ZG88_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110985504</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102256.1">
        <property type="nucleotide sequence ID" value="XM_022246564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZG88"/>
    <dbReference type="GeneID" id="110985504"/>
    <dbReference type="KEGG" id="aplc:110985504"/>
    <dbReference type="OMA" id="VWAISIM"/>
    <dbReference type="OrthoDB" id="438268at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102256.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15684" checksum="279F72D367F3BBE2" modified="2022-01-19" version="1">MQCKADLLKRYQPQITTSWVKDGLPVVASQRLELDSLGTLRITNPVPEDHGLYACQAKYWDTVITTNEIRLHAGPPGRALGESSFWIAQNNDIVGVSNVWAISIMLITAIGIVWLFVVIVLRLKRSRCCGKDYELVASTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZH22</accession>
    <name>A0A8B7ZH22_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily B member 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Endoplasmic reticulum DNA J domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110985668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with HSPA5/BiP; interaction is direct. Interacts with ERN1/IRE1 (via the luminal region). Interacts with DERL1.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102546.1">
        <property type="nucleotide sequence ID" value="XM_022246854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZH22"/>
    <dbReference type="GeneID" id="110985668"/>
    <dbReference type="KEGG" id="aplc:110985668"/>
    <dbReference type="CTD" id="4189"/>
    <dbReference type="OMA" id="HSQHKRH"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051948">
        <property type="entry name" value="Hsp70_co-chaperone_J-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44360:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034990378" description="DnaJ homolog subfamily B member 9" evidence="6">
        <location>
            <begin position="24"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022102546.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="27784" checksum="9665A01F85F920AA" modified="2022-01-19" version="1">MQYQIILAFGATTLSILLLLVEGKGEDYYKLLGVKRTETDRGIKKAFRKLAVKYHPDKNKDPDAEDKFVEIAKAYEVLSDPEKRKLYDQLGREQFESYSNRGGGGPSPGSQGGSFNYRSFFKDFDSSFNTFRNRRSTGDHRNSGKRASGFNFFADDFWEDFDEDLFGFGSFRPSKNNRAGNHRGSHDSFFGDLFEDVAFAEFPSTVRTSHHFTTTTHRHASSGGRTCRTVTQRVGNTITTYTDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKG9</accession>
    <name>A0A8B7ZKG9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987257 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105532.1">
        <property type="nucleotide sequence ID" value="XM_022249840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKG9"/>
    <dbReference type="GeneID" id="110987257"/>
    <dbReference type="KEGG" id="aplc:110987257"/>
    <dbReference type="CTD" id="5546"/>
    <dbReference type="OrthoDB" id="10388885at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105532.1"/>
        </source>
    </evidence>
    <sequence length="965" mass="104909" checksum="757E3C28A78AB5D0" modified="2022-01-19" version="1">MSLVNYNSSSDDETSNAEEETEEQSNVGKRAEEASSSTLMNLSDLEEDPRSKSSLFSSLPAPKLLDIHQPEETDDIQFPATASTTSSSSSSTGRSLNLPAPKKKSAQPIKITAPSLPETHSDDDEEEPLAKKARPAKTKHYLGRHSLGSPAINSVASHNIGGNNHLAGGGRMDSRNSSSPGPDRNLLRKKKCTAKERGEHTMEELLELSRSAMEQLHQKLELQRHQMVLLSGGGFGLHQTNSTPSFPKAGPAGHTTSNATQLQGLAQVFPPALGFQGSPVLNAALHPGLASLMQAPGLDLPRNAGLLGSQSLPFASAVNVSAANHDLTKSLLSPFPFPAINPGGIAGLQPFPLGSAVGISQPLAQPGWVPNTHPPSPPADSDHSPQVTHKNCCGACLKKIDLLEQKVKKILEHLITKELAQGSTLPPVLDPFPAPTSLASQSPSPQDGHTFLNTSPSGGSSSVPSSSALQVGQEMQNAFMQAVHHEQSSPFQSSTKPRIVYPQLMTDPLIPVKISSAAEHKCPPKLADPPITTNVAPAFASLCSSPSDSRRLTPSSVNACSSQTKGPLLLSSKITLPAENNDKYAYQSLMRYRGTSKLFKIDYDQHAAHKSNIHFNQGGDSSHLSVEDTCMLQTDHFQFPLEIYSAADFHSLPSKIQYILNVVERDKHGKATKLEVKQEILNSLAPYIKDRNSISRRLADVLFTDDERCYCNCSGWRKPAALDPIRMQALTDAVFKLCPCPEEQKKHLWHECVKSIDAASRHIVRVRKNKGKMPRHGKWLPTNHQEPAEQPLFAVATMEVDPSHEGINYDNLPVRLQSVLDITQRDANGKVCKVEIKEPVLVRFTYLSNSRLNVACQLANILFTPAEREGASCLGRPGTRQLDSIRLDALREGTFRICPAPLTEQKHLWSYCVKAIDRLSVNPDMSYPTSSATLVYPNIKAEDETPGEYEVLAEDISHSSPEDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKX4</accession>
    <name>A0A8B7ZKX4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UDP-N-acetylglucosamine transporter-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110987269</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105545.1">
        <property type="nucleotide sequence ID" value="XM_022249853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKX4"/>
    <dbReference type="GeneID" id="110987269"/>
    <dbReference type="KEGG" id="aplc:110987269"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000037">
        <property type="entry name" value="Nucleotide Sugar TransPorter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022105545.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="38796" checksum="D4063C69C083ACDE" modified="2022-01-19" version="1">MVEASTTGNSANQAEQDSLLPMPAVKFNLKYFSLGVLIVQTTSLVLTLRYSRMVQGEGPRYLSTTAIVMAELFKMLMCLLLVLGGEGMWNLSNLATIIREQIIQKPADTLKLAVPSGLYTIQNNLLFLALSNLDAATYQVTYQLKILTTAMFSVVMLSKKLNSYKWTSLVLLMAGVALVQMPAESQAQEKSESVPSKNQFIGLVAVLSACFSSGFAGVYFEKILKGTKQSIWLRNIQLAFFGVLFGLGGVIMNDGEKVRSAGFFQGYNNLTWIVVLFQACGGLIIAAVIKYADNILKGFATSLSIILSTVVSYYLLNDFVPSRLFFIGATLVIGATFLYGYEPPKNSQLSLPKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMA8</accession>
    <name>A0A8B7ZMA8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC110986683</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110986683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104476.1">
        <property type="nucleotide sequence ID" value="XM_022248784.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104484.1">
        <property type="nucleotide sequence ID" value="XM_022248792.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104492.1">
        <property type="nucleotide sequence ID" value="XM_022248800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMA8"/>
    <dbReference type="GeneID" id="110986683"/>
    <dbReference type="KEGG" id="aplc:110986683"/>
    <dbReference type="OMA" id="VKCIVAV"/>
    <dbReference type="OrthoDB" id="5986675at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022104476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022104484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022104492.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="24284" checksum="BE0B7F59B75AB32F" modified="2022-01-19" version="1">MSSRVKWVVGGVVVCLILTVIIVVAVTVSKANRNEEKSEAAPPTNDQPRLTTLKGNTGGLAPTNQPGLTASATFVNKSVTLASVAVFTADRLEIKLNCTFQYYVSPENLQILNDTYGPAYELILVFSATDAVKGVGSQFSFRQYAYERDAVEQALSDAVRSRLQGTCCEPSCQTLPGGCEAGCKPTQECTDQDRGLFANVLFFRLDAVDIPDIILSRLPTASPPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNQ6</accession>
    <name>A0A8B7ZNQ6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110988115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107059.1">
        <property type="nucleotide sequence ID" value="XM_022251367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNQ6"/>
    <dbReference type="GeneID" id="110988115"/>
    <dbReference type="KEGG" id="aplc:110988115"/>
    <dbReference type="OMA" id="GPTYFYD"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022107059.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33987" checksum="8E4E5730DD37045C" modified="2022-01-19" version="1">MVMVIAVFGATGTLGNSVARALLTDSSNFQVRAVTRDPNKPEATALADKGAVVIKADMNNRESLVPALKGADGCFVATSMQLSDPLCQQLEYQQGECVADVCMAMKVPHIVFNAQNHVSKVIGVKARHYDAKACINDYMNERELPLTSIILPFAYENFLGDFKPQKLQQQEYSIGIPMGDLSLNMLSIKQIGEAVRYIFYNKTSTVGKTFSLVGDKLTVREIASILTTHLRPHVVRDAKVTLPEFHRQNSSKPGNEDITNMFDFIHKVTQRFSIETTRKLIPDLLTFDQWAAQNKETLLKILNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNU0</accession>
    <name>A0A8B7ZNU0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110987890 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106727.1">
        <property type="nucleotide sequence ID" value="XM_022251035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNU0"/>
    <dbReference type="GeneID" id="110987890"/>
    <dbReference type="KEGG" id="aplc:110987890"/>
    <dbReference type="OrthoDB" id="10485803at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106727.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37202" checksum="8D05D9EC7FC6B552" modified="2022-01-19" version="1">MQWLSCCGNIMIPNRFHHPSGLLMVVIISQFSLDTSYGASDVPFVCYQGSIESNAKGQIKRHSEMNLASLPCDQPITPTSGHPTTTADTDLMPNSSHPAQPSAATTPANASQQHNASAANFCVVDYFPSGSRLSTNGTWTANFSCVLGTAACPSRTCCKTPNCNTLEFFRKGHPALKTATVSSCHKGNVTGSGPVPAFPCRSGSQYCYNQTTDRGTLFGCSTGTLQISCRKNTVGSNSRCVNVSRSSLCCCDSDNCNGLSPNITVVTPIHTVAPPTTTHYLVTASKHSSGWMLVLLITCGFLIGGLVGVVATVLYRRWKKKRRANGPLKISYSRISADCVDDDNVFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPW5</accession>
    <name>A0A8B7ZPW5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bis(5'-adenosyl)-triphosphatase enpp4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107628.1">
        <property type="nucleotide sequence ID" value="XM_022251936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPW5"/>
    <dbReference type="GeneID" id="110988444"/>
    <dbReference type="KEGG" id="aplc:110988444"/>
    <dbReference type="OMA" id="GEMEYVN"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034794389" evidence="2">
        <location>
            <begin position="29"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107628.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57137" checksum="497C0F78AE92A49B" modified="2022-01-19" version="1">MALVWSKQGPVSFLFFSLLLTMFSVMSALPSQQTPSTFGTPLVLLVSFDGFRWDYLDRTDTPHFDSFVREGVKAKYIFDTFASKTFPNHYSIATGLYQESHGIVGNVMYDPFSGANFSLSVKQNPVWWNDGEPIWVTNQKQGGHSALIMYPGMEVKIRGQYATYRLPEYNSTFPFKERIDMITNFFANDSVNLGLLYFHEPDHSGHVLGPDSPGMDAVLQMCDETLGYLMEQLRNAGLDDRVDVIITSDHGMTPVSSNNFVQLDDFVDPSLYHYTNNNPVFGIWPFKESDVEVIYSKLQGVGPNVNAYLKEEIPARYHYRAHPHIAPIVLVAKEGWAIHRGNDTSRSYYLGNHGYNNSLMSMHPIFIARGPSFRRGLVVEPFENVNIYPLICQILGLEPAPNNGSLGNVQDLLRYSGVVKKSTTPETFTTESGSNAKPPSSTLSTSTIIGIAIAGAVLIVAVCLLVAMCARQRSYRQPPRQYTPIADTSLDVADDDIDDSGFSSYNYPNTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQF2</accession>
    <name>A0A8B7ZQF2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">JmjC domain-containing protein 7-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105661.1">
        <property type="nucleotide sequence ID" value="XM_022249969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQF2"/>
    <dbReference type="GeneID" id="110987321"/>
    <dbReference type="KEGG" id="aplc:110987321"/>
    <dbReference type="OMA" id="DNINCIL"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000025">
        <property type="entry name" value="Lysine-specific demethylase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF42">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="145"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105661.1"/>
        </source>
    </evidence>
    <sequence length="411" mass="46284" checksum="4AAD273CAAF732DB" modified="2022-01-19" version="1">MVTRESILRSSLGAVRRAFLSCNIVVCVVCFFAFSSSKNVDCVDEPPAMPAGHLKPLGWHRVAEAGVDTVQFVPEPGVFFEDYVRKGRPLLMKGAARSMKAFKLWNDEYMRAAFGDVEVEVEEGKKENRSRGLWAMRLDEFLDEYQLGDMYMVASVPREMAGEVELLSCMLCGGFTKNLQDAVIWFSSGDTKSVLHFDALDNINCVMDGRKEFFLVDKNDKANVFIDHPEGSFSGVDVDKVDMYKYPGLSQVPWYNVTMQPGDCFFIPYRWFHQVRSAAGRSLAINIWFVHLLQFNSSDCKAKGKLPDFEPLAQFELASDSEQLRGEIANFIDELDDAELHIEDLSKLAADLEISDQESLKVFQTLDQDKDGGVTIDEVYSCNMNNVQAQAPGLATRDTDGEKFDDNHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRP5</accession>
    <name>A0A8B7ZRP5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Unconventional myosin-Id-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988756</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108248.1">
        <property type="nucleotide sequence ID" value="XM_022252556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRP5"/>
    <dbReference type="GeneID" id="110988756"/>
    <dbReference type="KEGG" id="aplc:110988756"/>
    <dbReference type="OMA" id="KGDYLNM"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000004">
        <property type="entry name" value="Unconventional myosin ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF713">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="10"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="9">
        <location>
            <begin position="813"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="7">
        <location>
            <begin position="573"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022108248.1"/>
        </source>
    </evidence>
    <sequence length="1006" mass="116405" checksum="D233ECD51158C1D2" modified="2022-01-19" version="1">MAEHDEGAEFGKGDFVLLDEITEEAFMENLKLRFEHSKIYTYIGEVVVSINPYRTVNIYGPEVVETYRGREIYERPPHIFAIADAAYKSMKRRARDTCIVISGESGSGKTEASKIIMRYIAAVTNVSKQQEVERVKNILIQSNTILEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVVRQQKGERSFHSFYQLLTGANEQQLGDLQLKRDFSLYHFISQGNVEPAAFNDKKNHKATLEALRDAGFSADQQASMWKLLAVILHLGNVHFESEDKETCSVSNPGELSTIATLLSVSQEELQTALCYRVVAAKGEVMEKSHTTEQAYYGRDAFAKAIYERLFTWIVGMINSAIEVRGTSLEHGKNTVIGVLDIYGFEIFDDNSFEQFCINYCNEKLQQLFIMLVLKQEQEEYQREGIEWVTVEYFNNRIICDLVEEPHKGIMSMLDEACLNVGKVTDQMFLEAMNQKLATHPHYTSRTLNPADKSLEYNRDFRIRHYAGDVMYDVNGFMYKNKDTLYQDFKRLLFLSSNPVISEMWPEGQKKVTEVTKRPLTAGTIFKNSMIELVKNLASKEPFYVRCIKPNEAKSPLLFDQERCLHQVRYLGLLENVRVRRAGFASRQHYTRFLHRYKMLSQFTWPNFRGGADRQGVELLLQEKQLEDDVAYGKTKLFIRTPRTVYALEEARAQLIPHIAVFLQKVWRGTLARQRAHKMRAIYRIMASYRHFKIHRYLYKLQDTFRDVKNLNDYGKSLEWPEPPKVLKKFNRMMHKSHRQWMCRLVLNRLPKDDWPEMKLKIAAMDALNGRCQDWGYKRKWQGNYLASISENNQTAPFVSMCNQLKNKDHFNQILFSSSVIKINKHNKCADRALLVTDKFIYKLDPKKGFKPMRIGTHMSEVTGMSITPGSDQLVILHLSGDNDIVVGLTNTRGENRVPELIGVLCRQWIESKKRELRLIVTPTLNCQLGKHRKTVSVQKVSTDRPVFKKEGQNLVLLWPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZS93</accession>
    <name>A0A8B7ZS93_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="12">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110988773</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022108279.1">
        <property type="nucleotide sequence ID" value="XM_022252587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZS93"/>
    <dbReference type="GeneID" id="110988773"/>
    <dbReference type="KEGG" id="aplc:110988773"/>
    <dbReference type="CTD" id="5303"/>
    <dbReference type="OMA" id="NAINVRH"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13616">
        <property type="entry name" value="Rotamase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="14">
        <location>
            <begin position="48"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022108279.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="14728" checksum="01DDED1538DDF30E" modified="2022-01-19" version="1">MPKNKGGGGGSGGAKGGGGGAKGKGGKGKPGGAAAADDDGGGKQKKGGTAVKVRHILCEKHSKCMEAMEKLQSGVRFNVVAEQYSEDKARQGGDLGWMTRGSMVGPFQDAAFALATSTTDKPIYTNPPVKTKFGYHIIMIEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSV6</accession>
    <name>A0A8B7ZSV6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110987781</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110987781</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106541.1">
        <property type="nucleotide sequence ID" value="XM_022250849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSV6"/>
    <dbReference type="GeneID" id="110987781"/>
    <dbReference type="KEGG" id="aplc:110987781"/>
    <dbReference type="OMA" id="VENAWEN"/>
    <dbReference type="OrthoDB" id="10413555at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034325462" evidence="3">
        <location>
            <begin position="29"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022106541.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="64565" checksum="5D405A0EE40D3DF6" modified="2022-01-19" version="1">MGIYRVRTLLVLAVSLCVLWMNINSAHGRPEQKGGVALKKVLKPCVDQVQPALQKESNHSEPVVSTPCDPGDVPPVKGVPEKLPVTLATKLDTITDDYSNESSFTEKSLKHEQKEDLSGGTTGLNSDEVLRSELEEEVEAVDSLAPRAPHPEKDAGADSSVTTEATLRKPGQDIATNKHIPDEKKSELFIDSGIFPFIAMGVLSALFITMMIAALYFARHSSDIQHHHRQISMKPLGLGPVGLPTSRNSGSAFHTVTFRNAQDGVIGDFAVNMFAVHQDAREEASRELTNMSESTLLATPSDTAVSKAAPEPATHEAVRSTTTLLHRDLPDVVSTPSSRRETMSNNRHSTGSSLYMELINMCRNTRLIEELALRRKNIRMQDASQPENDEMFSSDTDSKSGKLVVRRQVSLDSGRCRNTVPLPSTYESHYFKLYDGDDDDSSALASASASANTTMDAVPFSSDEGCSSTLNSLHRKGSSKRNSRLLDESRQLLPVQEFFNEAMMDSSDGGDVLYETIDEMGYRRRTASSQAIRRLMEARESAGHAGETIVVENAWESSPKKYDKIDRSITAYKKHIAVDKDYNTLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUH8</accession>
    <name>A0A8B7ZUH8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110988173 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107156.1">
        <property type="nucleotide sequence ID" value="XM_022251464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUH8"/>
    <dbReference type="GeneID" id="110988173"/>
    <dbReference type="KEGG" id="aplc:110988173"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="2">
        <location>
            <begin position="206"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107156.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43088" checksum="9D417207DFA2EE95" modified="2022-01-19" version="1">MWNHSWVSFTGFSESYNGTFKLTGHTGLSAKNVSSAFFNGELENEMRERGHLDMFHMVKVDMDKDKVLAEVEKVVDVCLLLMRSGIAISSLYAQVKSPSSKVPIPGLPDVCTNPPVHGQAFCSPHCEAVEKTNTQSGLHAFLKHCRVSDSTFNDVAAVLSKLEPSSGGTSVIEAQAVGMHNTGEFTALVDELSEWLIGQGVTNLWRLQFEEKEAVVKDLFVHHIYHRVQSCIQQFTDGLGPLYGEMRRHPKALGSLFVVDNKPLSLPSFRKLYDIEYSAQGSNNRNREDTIYCWELFLQRAEEKDEVTLEKILEFWTGAGKPPPAGFNHKLHIQFFSQETGVRRLPSSSTWAMVLWLPRGVEDPQQFQAMMTNAILETQGFGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX93</accession>
    <name>A0A8B7ZX93_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC110989826</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022110168.1">
        <property type="nucleotide sequence ID" value="XM_022254476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX93"/>
    <dbReference type="GeneID" id="110989826"/>
    <dbReference type="KEGG" id="aplc:110989826"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="59"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="141"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="260"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="563"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="848"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="705"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="570"/>
            <end position="577"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20 22">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="709"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="723"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022110168.1"/>
        </source>
    </evidence>
    <sequence length="866" mass="95458" checksum="4A7FE0432BB02A6F" modified="2022-01-19" version="1">MQSWSDPLTLPVSNGGISTLRLSNITRFQAGNYTCSSSNGVSTTHGKFPNVALIVHYAPTFLSVQRFPDSPIVEDTEVVLTCIVDAKPLPVVVTWEKQDSSYAMTSLVNNDGISTLTLSNITRDQSGYYTCPANNAFRQMPQVPIECRPWYVAGISNKDSNDVHVRSGEDATFICTAAGNPKPALEWYNPNGTRLTNSLRSVTIVESAASGDDVVGYVVRSVLVVHRVNSRADCGIYICVASNGVGERDSMAASLLEARRPGKPTVLAVGRTVDTLTVTWIAGHDGGKYQWFEVTYRETSDATGREVSEGDVPGLTNIYTVKGLEPYTEYEIRVYARNEVGRSPKPGRVVGFTLPQPPTSAAGFVLDSAAGTLSVRGFKGGADECLRLEAKTKDNGNWSDCGGCARTDTQILLSVWCKTNQESDSSIKEFTEVRSRICHGEVCSEPIRAEGVNDLPRGKPPLGTSGKLNIGVILTIAVAALLLVVVLMLSAVAWKKFKEHTKGETQVREKDAENESLNSMWQCSYGGKQGKEITDLTASRQPEPMHEYANVPTVHRAFPRDKLQIVKELGHGAFGLVLLAEAMGITEESKTTLVAIKTLKRGAVDSDRTSLIKELDLMKKIPEHTNVVKLLGYCVEQDPPYIIVEYLSLGNLKDLLDSSRTKDGREYGNLHGVSRSLTAKDLIKFAKDVADGMAFIASQQCVHRDLAARNVLVAEDMTCKVSDFGLARDVMNIRTYKRGSGVMLPVRWMALESLLDDEYTTMSDVWSFGILLWEIVTLGARPYPRMDNISVMYKLQSGYRMPKPKYCQEDLYFLMLQCWEENPLHRPTFAAISEELQMLTKEGRGCDSIEESSTDDIKSEDDEDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXF1</accession>
    <name>A0A8B7ZXF1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Craniofacial development protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110989578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109772.1">
        <property type="nucleotide sequence ID" value="XM_022254080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXF1"/>
    <dbReference type="GeneID" id="110989578"/>
    <dbReference type="KEGG" id="aplc:110989578"/>
    <dbReference type="OMA" id="RVPDEPW"/>
    <dbReference type="OrthoDB" id="410381at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022109772.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="34277" checksum="B06BFA169BAD6786" modified="2022-01-19" version="1">MANLVTTNPILPVPGVDRSCAADSGVGQCSTRQYDSAPPTPDDSIKPKAILRCKRPFIVATFNANTVREEGRLREMDHCAVKCGVEILGVHEHGRVHSDTIVFEREEGSYFITSSAWRNAAQAANGGVGLLLSPRARRSLRSVRSHSERILVAEFDSNPVTTVLVAYSPTNLSQVKDVELIYEQLTAAVRSMPALNVVAILVDFNSRLGSDNVPYTCHYTTRRNGTLMYGFMTEHQLLAADTEFQRKYGNRLIFRDNGTGIIRQFDYILVRRKWRNSILNAEPFSSFASVGSDHRVVSMKVSLSLRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXR4</accession>
    <name>A0A8B7ZXR4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110989930</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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    <dbReference type="OrthoDB" id="419734at2759"/>
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        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:folic acid binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="MFS"/>
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    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
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            <begin position="27"/>
            <end position="47"/>
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    <feature type="transmembrane region" description="Helical" evidence="22">
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    <feature type="transmembrane region" description="Helical" evidence="22">
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    <feature type="transmembrane region" description="Helical" evidence="22">
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            <begin position="398"/>
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    <sequence length="435" mass="47913" checksum="CCF5CA1D012B238F" modified="2022-01-19" version="1">MTQIQEAKATLNPVTRQTDRERAQSRWITVEPIIILTMMGYTCIALVKPLFVKDMLSQSYNYTEPSNTNKCTVAHSGNGSLEDQIQSESSMWLLYLGAASGVPAMLSSTVFCTVSDRLGRKLAMALPAIGFAIQAAVYGVTVHFKLPLATLLAGEFVQGLAGGFGLLFAACISYLADATTERQRTMRIVIAEMLTFLVGGLNQVAQGYLIKISYLPSLAIAFGCNSAAFLYIILPPFLIETVDNRGFDRKEFFEAWRSMKRLLEFNENGRRWQMLFLDFFIFFCVCQFQGMLVGTKVFSFCLGDYWLMQISCLSTVISYLTIGLARSTLVIFLGTAVGFLRGMSIPVARSVLSKITHPDDIGAMFSIVGCLESLTFASGLLANSIYAASVSFVPPLTFFVYSGATLIPAGITLLLQLCWPRRKEYTSLNVIVNAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYL9</accession>
    <name>A0A8B7ZYL9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Telomerase-binding protein EST1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110990037</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_022254816.1"/>
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        <property type="nucleotide sequence ID" value="XM_022254817.1"/>
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    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005697">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0070034">
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:telomeric DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PIN_Smg6-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
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        <property type="entry name" value="Est1-like_N"/>
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    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
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    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
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        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00670">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PIN domain-like"/>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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            <end position="1696"/>
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            <begin position="1"/>
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        </location>
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    </feature>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022110508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110509.1"/>
        </source>
    </evidence>
    <sequence length="1717" mass="194103" checksum="1B26685FAA37F073" modified="2022-01-19" version="1">MENAASDDSQSDVSTKSSRQRKEVRRPDMAIYKPGQSRLGKRSEQDPPPSTTDNDTTPASSIKNIQGDHRLQDTSKAQSQKPKPTQHGDKGQELKQPPPHQHGKDKREGRSSVHLEDRKSTSQVQRSGRDNKRSDNQGNRSSRGNKVSHPRSRPDHDSSVRTKDVKKETGSYIKPAAKPPQDRNAGDDVRKEGTVETKSGPSPESKPASEQQPQVQREKRWHGPQGKRKNAKDDTKTGRHLGSVSKKNSERVNIPIGDAELASDSSLVRQADSQTEASTKNHNWLGKQENHNGKAPKRSQSNEKAPSSNHHGNHAQQTSQESKKTFHGSKQHSHQEDEAKRSHSISSETILDKVSRQKKPDRSFYVSPKLAGSQGQDEPKTNESETNTVPPEDKIETMVFTSRKSSNQNWSQRTDNSGSKNSKPADSLQGKFTLENNKKVPLKSLLDLQVSPPGKGMASKTPKTELKSQNEAKSPNADTRSKPAPSSKRYSARRSRQRYNSESSTGSDNSQFVDVAQSKSEDLDRDLAHTDSKLQNLSLKDEFKGSYESISSTDSGKRVGTALSQKKTLQSQNQRRHLDSRADAEVSERQPAKRETGKQVFEKGKLTVTFNSNVREVTLSPEEERERRLEEESQDGRSGDRRQSGRNRHRDRESRRTASESEETQSEHASKGGGLIRLPQKRSDPISIHSQPANQQQQQSEQGYRPIYDRYYNPPQPASEPKEEPRPKDARGRPGNRNLLWDPSKPQERPALASAKKPESTDYHFYDPEQGGSPGERKFDPRGHFQPQGYGAFYPPAYPAMPVQHTVYPSPGFYPAMSWAEQVEAHNTDSKVQAPSPPTQVGNYQGNFPPLGASPDAPMATETPTSVAAPPSSHSHSVAHRILQDTARYEHSINNAVSRRFHGEEGVQKIMKLSQELERMYEQVILTDLEMCNKHNIEQLLWKTAYYQVIEALRRQDVEEPGTYKLYLEQLLDHGDDFYVSLLEKLQSAYSFRLETRTGLDPLHEEPRRAIKLALLSAQRCMISLGDIARYKELTNDTSNYGKARSWYLKAQHLAPRNGRPYNQLAILALYTRRKLDAVYYYMRSLAASNPFLTARESLMSLFEEVRRKVEHKEKAQVQAKEVKERAKEDERRRRAKERRGRRSQAEGGRDDSQATRREIWIASDGSSHDGSELAEDNEEEDGEATLRRISPVEINKRFVLSLLNVHGKLFTKIGMEHFSFIAERLLKEFRVLLTHTPTPVTSTRIVQAMAINMFAAHNTETKDQSPREDLRSLLQEQAIQLGLDMFGLLVSRCNQLLTDHLKSDTQGRVLLSEDLLELLPGVKVYADWLMCHPQLWNPPPSCTDKPYSASVDVWSSLAELLNTLKRIDTNVVTFIKKTDENGCQEILLPEDVQLSGFVPLIALPLQPVYIPSDTNKLEAMDCVRINSLLLFGEYACGQETPLLAYDVSKNCYISVAPELVTTEKVEQRPDQADDDVIIEEEYYEDAEESSGKEGEDSGDVSSLRQKKEDLERRLQQQQQKQAQIQATMESHRQQLYLEVEIRPLYLVPDTNCFIDHLSKIQALLACRKYKLVVPLVVINELDGLAKGSRDDLYEEPSQALRVQEGAGSAIRCLEEKFGQRNKYLRALTSKGTVMDTIAYRSEEVDFKGCNDDLILKCCLHYVDDRARDFMPTTKDAPIRLYRDVVLLTNDRNLRVKALQQNVPVKDITAFAKWAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYU1</accession>
    <name>A0A8B7ZYU1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">D(2) dopamine receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110990142</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022110688.1">
        <property type="nucleotide sequence ID" value="XM_022254996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYU1"/>
    <dbReference type="GeneID" id="110990142"/>
    <dbReference type="KEGG" id="aplc:110990142"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF66">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-3R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="41"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022110688.1"/>
        </source>
    </evidence>
    <sequence length="468" mass="51499" checksum="67B5D20628B48268" modified="2022-01-19" version="1">MNTMANFSINNSQANCVFQDSPSCLLFQIFMSIIAAFGIFSNALVFIVISKFPNMRNVPNYLTASLVLSNWFVCTTAVPFGVLLSEAPDVCRKIACGVPLGISIFLTMVSLWSQCPIVWDRYFIIKLPTVYPRKRSARGAVAAIAVTWLIPALLATPYIAINPDTPSHEHAPAQLHYHPVGPGFYLFCLIVGIGLPILALVLANVAILVEVMRRRKKKIRSLPAALSSKVPARASLAGTSLTALPVLHPIPKKAQSEPASCRGGRKITVSRVNRALICAPTLGEHSSAHDQRPSRVVPRYPLLESTKGRKHGPNLHLKLALPLRHGMKPGTGAPHCRRASAPSTRPSHQGSTISRQAKRRAACISVIHAHGLGTGQGRQVPQAFWFRRERKTFLVTFVILGITVGLMLPMFLFESYVSVGPGTPLLGHMQVSRMLWWLSWCNSAVNPIVYTVFKKDFQVHFKKLFHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZL8</accession>
    <name>A0A8B7ZZL8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein LOC110990059</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110990059</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110547.1">
        <property type="nucleotide sequence ID" value="XM_022254855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZL8"/>
    <dbReference type="GeneID" id="110990059"/>
    <dbReference type="KEGG" id="aplc:110990059"/>
    <dbReference type="OMA" id="YTRIERY"/>
    <dbReference type="OrthoDB" id="10040049at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000054">
        <property type="entry name" value="Adhesion G protein-coupled receptor E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="951"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="984"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1023"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1055"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1096"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1142"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1167"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="15">
        <location>
            <begin position="763"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="16">
        <location>
            <begin position="949"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="100"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="292"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022110547.1"/>
        </source>
    </evidence>
    <sequence length="1267" mass="134343" checksum="BA6260F29A0AA2A9" modified="2022-01-19" version="1">MEEVTVILVYLGIMAFANKLEAVTSDLDLILESGHLIIDTDDATMMYFNEVDEGTATSTILYNETVVSYLAMTDNSTTPQADTSTSTFSHWNVSLTKVKTDADETTPKVNEELTSADGLSTLSENITSVKATPSSTSSNQSIETSTPDVETPGSTSGNTNQSAETSTSDHKPIFGNSTDVPINSSEVYTSLSRLSNASSTPLLSDTYKLLFQGTLKNVTYKDTGSGEEWNYSIAIFSTQGSIELKGNLTISVIGGNALRFQSKEGNILIGSDINLNGREGISMLVGGFQGLPSPGGGADDSSVPGGAGHGGHGGGSFRESQTQPCSWGRVDQSPSDATSIQSSTSLETEGTTHKQTANTPLEANYTTAWNDTLATANGDNMTGTTRTEMTGSLISQTDTSSPSGVTVSHLLNDSTLDWKTVSKTLHLNTTELFPGITDVSITTNLTEKLNSTLPNDDSDTTLESTVMLTDPINSTSTDLAATTTDTPTGGDEILYRCTYGFPYLLESYRHLLGGSPGGIASQGVARMGGGGAIEFRARKGSVTIDALVTARGQSVSKPEPGDAPCRGGGSGGLIRVRAKAVLVTPRGSLVVSGGDGSTVGCGGDAAGGGAGGVIQIKVSEMIESHQSFLLSGGFGSSCSGQDGFLSVVIEGGSGGGDGGCQCNTGPPPFPPFNPSPSSMSTPAAEITHAALLTNSPTDMTTFLPKDMTPDEAADYLKDIFTADANLTNATTSTEAAQIMGNIEQIGLKFGRILAKRREPGETINITVISEELAMQLDILEASSFSGHIIPGPDLKSSNATSRPGAITIHQSVLPTKATGSVIIVGTFYVRMEQFLSGALATPSGLEAGYDINSVVLSATLELTDNSPNFIGGVSIAAANHEKSTGRNTLCAFWNFSQHNDFGGAWSTSGCSVNVSNGTYTVCTCDHLTNFAVLLKPTDFILPPGHERALEILTYVGLGLSLACLVVALVTLAALLRSLKNTDSAVIHLNLVIALTVADFFFLVGASDTGNKVWCKTVAGILHYTYTVTFMWMLMEGIYLYIRVVHILHQPSRTTLKYFFLAAWGLPIVIVSATVLARPESYGSDQACWLDTANGAIWAFAGPVLVIIGVNIVFLAVVMVRFVSVKSIAKQSKWKQTRKTTRAAVILLPLLGISWLFGLLSVDKNTLIFMYLFVIFNSLQGVFIFVFHCLTNDDVISTIRIKLRKSRSRFDFHHSWPNGIKTAFTRSPVKKKKKNSVHPSTQTSITLLDRSSFPSNVGHWTDVKQRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZP1</accession>
    <name>A0A8B7ZZP1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110990078 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110990078</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110572.1">
        <property type="nucleotide sequence ID" value="XM_022254880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZP1"/>
    <dbReference type="GeneID" id="110990078"/>
    <dbReference type="KEGG" id="aplc:110990078"/>
    <dbReference type="OrthoDB" id="8251209at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029415">
        <property type="entry name" value="Lines_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032794">
        <property type="entry name" value="LINES_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024875">
        <property type="entry name" value="Protein_Lines"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16057:SF1">
        <property type="entry name" value="PROTEIN LINES HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16057">
        <property type="entry name" value="WINS1, 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14695">
        <property type="entry name" value="LINES_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14694">
        <property type="entry name" value="LINES_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Lines N-terminal" evidence="2">
        <location>
            <begin position="542"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Protein Lines C-terminal" evidence="3">
        <location>
            <begin position="990"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="964"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022110572.1"/>
        </source>
    </evidence>
    <sequence length="1032" mass="114191" checksum="FB166B15B3B66CC4" modified="2022-01-19" version="1">MVHNVSAGRSKAVYIMAMQDALVTKLYEYLQRKTCLCHMAGTSKLRDLSSFKSWLRGEDGTENARALRGVEDQRGLDDVSIQKSTARTQDDTGYLEHHGTDRVSLQPLETCTSSPGDPLNVGFADQSCEEICESDQTRHKLAETTNAVLDDSLQRDVDDSDSCFRPGDKSCPHQRRLPADSGKLLRADDTAQVQVGTLQRMEHGQLERSSVPDQGFCWKIRTCPFTLRQVQEESSVTSTNRSFVAKSRDRKLLCLTVGKELFEAVHCLQLLSLQLEMVNRGSLLEELGVLMSSEDRLSAFMACKMAKAVLASSAVDKETAVSFLRHHLLCSLSAIRTVLQPTRHFDQNRRPLSPSGQLSQTERQRGQVHRGHTSPMEVVRGKIDLGQTDMHKVSQNDSGQICVGQVGSDQTTSGQACMVQRCTGLVNSGLTNSGQDIGGQVDKGENHTQMIHSLGNPNRSKHHPDLSEVNSGQVNHAIFTFDLCRLLLTKICYDENKEPNTQHPGPERNHTSCKGVFQKLADQAVRLQDFQTAVERTLRGDLPAIFQEVASLPPAGEDKTARVNWDGKDVSLVLVSLLDLTRALVRHRGGAAEQHCAREFAAKLASPLTHLLEGYCEDLVVLKRILDIFSWLMDHSATSALHSGQSHSSGHLPATVDYDLVTAATAFLKTIEKGNFLERFPYRSGPVGFGGRDFHPGGCDEDDSSGDHALLRKLCRAILCAVKTLVTSENSGKNSNKTDVGRCLQVVSDFVCRQLNLAASADVPMWLFELFADQDDGLVWAMQCCLDLYKAFKSVQPPGCPWTNQLNPHRIFGRFLDTVAYDPSVLLDLLISSETQFLKYLVSYLHTILGDWNLFRLSHQEASSKDSNSHLKRTSDMTSKTFSDDEEPHLACDVQCQEEAAVPEFCQRNKRRKTDTRGGADQRIASPTDALNRSPSIQTSTPACTSPKDTKKSSPTPSDMPGISSVSPAVQTPQTLSRQTDAVSQSLDDVMTTLIRLRFSIERISGSNLFPYPVAPLLRLLERVEDMYEGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0Q3</accession>
    <name>A0A8B8A0Q3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AN1-type zinc finger protein 2B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110990314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110932.1">
        <property type="nucleotide sequence ID" value="XM_022255240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0Q3"/>
    <dbReference type="GeneID" id="110990314"/>
    <dbReference type="KEGG" id="aplc:110990314"/>
    <dbReference type="CTD" id="130617"/>
    <dbReference type="OMA" id="VICNQCH"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1110.10:FF:000004">
        <property type="entry name" value="AN1-type zinc finger protein 2B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="85"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="214"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022110932.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="29952" checksum="32B9BD34A45A024C" modified="2022-01-19" version="1">MTLPSDDPAAHRVTVCRLPWVPPFCPPGGAHSEAGPVNSLPDVQVPVCPLCNKPIPVKRGEPPDIQVSQHIDSDCQSDPAKEKRRVFSNKCSLKGCKQKELVPVLCSSCQRNFCLRHRHTADHDCKGFQGSGRIISKQGSAAINRASSHGATGGSAEPQKATSDKNLDRGRGERFVGSHASQMHQHGTTQPSTVFQAALSEDEAMTRAIHMSLTEQQPGKSSPDLHVHQDQEAMDLALARALQESEREEQQRRRQEQQRAGQQQTSDASRCHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A141</accession>
    <name>A0A8B8A141_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990626</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111399.1">
        <property type="nucleotide sequence ID" value="XM_022255707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A141"/>
    <dbReference type="GeneID" id="110990626"/>
    <dbReference type="KEGG" id="aplc:110990626"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111399.1"/>
        </source>
    </evidence>
    <sequence length="116" mass="13634" checksum="5BF08CC3DB5352B7" modified="2022-01-19" version="1">GYEQQLRKSKQARESKQARESKQARKSQQESESEQESELEQAKGSRQLRKSKQARESKQARESKQARKSQQESESEQERELEQAKGSRQLRKSKQARESKQARESKQARESKQARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1A2</accession>
    <name>A0A8B8A1A2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990734</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111523.1">
        <property type="nucleotide sequence ID" value="XM_022255831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1A2"/>
    <dbReference type="GeneID" id="110990734"/>
    <dbReference type="KEGG" id="aplc:110990734"/>
    <dbReference type="OMA" id="ECENNIQ"/>
    <dbReference type="OrthoDB" id="8932879at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111523.1"/>
        </source>
    </evidence>
    <sequence length="522" mass="59399" checksum="850D88BAB099888E" modified="2022-01-19" version="1">KYGGPEAIEQDLQRRIEDFPKLSQRDNDKLLQYGHLLMEIEYVKDGGNCPGLLHLDSGRGLRRLVQKLPYNLQEKWLMEGARYKEKHQVTFPPFKVFSEFVRYQAKVRNDPSLTMPHDLKQHDMQKRAVNVRATEVKTVIQPQDGERCPIHKKNHPILKCRAFLAKSPPEKKAVLKEHRLCFRCCQPHHAARECKASVKCDSCGSKRHMTILHHDQHSEPVDKPQEPNSQPTLSQPQITSACSKVRGTTCSSGKSRAKIVPVLVKSKKDQSTCVKTYAIIDEQSNKTLATHQLLDKFNIDYREVHYTLRTCSGEESAHGRWADDFIVQDIRGTVSLDLPVVTECSLIPDFKDEIPSPDVARAYDHLKGIDIPEIDQNCTATLLIGRDVLEAHHVLEQRIGPLGAPFAQKMKLGWVIIGEVCLRGVHTGDGHRDKIVSLRTQVLSTGRPTFLEQCPNEFHVKHLFDNEADGVSLSIEEKQFVDLMEKEGNLQHGKWTAPLPFKEPRVRLPNNRQQALKRAQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1B3</accession>
    <name>A0A8B8A1B3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990447</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111147.1">
        <property type="nucleotide sequence ID" value="XM_022255455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1B3"/>
    <dbReference type="GeneID" id="110990447"/>
    <dbReference type="KEGG" id="aplc:110990447"/>
    <dbReference type="OrthoDB" id="6773618at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111147.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="43684" checksum="761AEB529EC5BC51" modified="2022-01-19" version="1">MHIKVLRSYTFKLQQSTDVLVKWEDGTKNIVKVKDIRSNTSHPLSKGTSILMWWAAETGTVVDYGPGSQNVKSDSDDEDDVPLSKLVHSVPEPASPTQVGLHINQCETFFCNEEVWAACTSCLCLLCFKHFEESSPCHLHNQFALPSQVSIPNPTETELNQEATVEKSFDEHLDYVIHNLDDIPLNRLLNTATESSVSEEVPEVSEHEEVCTSDELIVTPGEHPEPVPESSACWVNEKETSMTVELIATPEEHPVPIPESSACEAEPHSTNTQTAHPQPEDYVVEGSQPEEAVPDKTVKKLSKHKTAKKGRNLGLQYTSMTSDKDIPARRGLKPSCKGDYCNLMGFHCKYFTATRRNKIQDAYFDTGELHKQRTFIVSHVKHSYPQKPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2B4</accession>
    <name>A0A8B8A2B4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Tubulin polyglutamylase TTLL6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110989729</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110000.1">
        <property type="nucleotide sequence ID" value="XM_022254308.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110001.1">
        <property type="nucleotide sequence ID" value="XM_022254309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2B4"/>
    <dbReference type="GeneID" id="110989729"/>
    <dbReference type="KEGG" id="aplc:110989729"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053317">
        <property type="entry name" value="Tubulin_polyglutamylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47113:SF1">
        <property type="entry name" value="LD09343P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022110001.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="60580" checksum="AEC4BE88EDBB8874" modified="2022-01-19" version="1">MKGQLWSGSTRGVHTPLYLPIHAKFTLRVLLVVIAVLLLGILVTVWNIYQLRTMQETHLSGFHSSVEGIGTSGEEAKPILWLHAKRIESGYLDHILRVFERIGYRRGGPDSDWDVLWAHDYPFTELAMEIGKMKPHQKLNHFPGTGFITQKVHLATSSIDFVPKAFKLPQQSEEFKAWASKNPDKLWVQKSNAHRGIKVKPISELDLSAANSFIQEFIDKPFLIDGRKFDIGVYIVVTSVDPLRIYIVDDETLVRFCSKDYHPIDYNVVDKYVIGDDYTPMWQMPSFEKLYNEQHYSFRESLNSYIRSQGLDSSQIYPQVYSAIRSVFLNKYPQLLKSLNKFKHKNTFFELMRFDFVLDEKLKLFLMEVNMSPNLSSNHFLPNKYMYEHVIYNILSVVGIARNVKDKIKDSSQDAQAMQVSEKRILVRSDICGSPKCATCISSECELCFRCLVPDQITMLEEAYLEHTHRQSTRRVYPEPMTQEEARTYHRSRDSDLTPRNRILREWFRAKCIEDVYWCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2K6</accession>
    <name>A0A8B8A2K6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110989785 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110989785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a defensive agent. Recognizes blood group fucosylated oligosaccharides including A, B, H and Lewis B-type antigens. Does not recognize Lewis A antigen and has low affinity for monovalent haptens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fucolectin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110101.1">
        <property type="nucleotide sequence ID" value="XM_022254409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2K6"/>
    <dbReference type="GeneID" id="110989785"/>
    <dbReference type="KEGG" id="aplc:110989785"/>
    <dbReference type="OrthoDB" id="547680at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042806">
        <property type="term" value="F:fucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010185">
        <property type="term" value="P:regulation of cellular defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001868">
        <property type="term" value="P:regulation of complement activation, lectin pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF15">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034325892" evidence="8">
        <location>
            <begin position="27"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="9">
        <location>
            <begin position="200"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022110101.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31315" checksum="6F0784D02C14CB8E" modified="2022-01-19" version="1">MSRRNGHRYCWRTRDMLLLVLFHACCFQLKTGHCALRDLSIIGKQASQSTSHNSGIFPASAAVDNDNQTFSHTANAGDIHPWWRVDLGAEYCIGEINVITRQGCCGQHRFTAAVARAGLSSNYARNQPCSSPVPRAQATDGATITFPCAPARMARYVTLDIDSSRQEVTYALLQLAEVMVREHVNDLTTAQPFGKSLSRMTNTFFKLHKGALIANSLPLATNVAVSLTRCARYCSKDVRCFSFDFAPGDGQCRIHSLNTFDIAMTPSENFSVWVRSDEVVQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3I9</accession>
    <name>A0A8B8A3I9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BLOC-1-related complex subunit 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110990007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BORCS8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110451.1">
        <property type="nucleotide sequence ID" value="XM_022254759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3I9"/>
    <dbReference type="GeneID" id="110990007"/>
    <dbReference type="KEGG" id="aplc:110990007"/>
    <dbReference type="OMA" id="MHCGKTS"/>
    <dbReference type="OrthoDB" id="10044187at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019320">
        <property type="entry name" value="BORCS8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146:SF0">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21146">
        <property type="entry name" value="MEF2B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10167">
        <property type="entry name" value="BORCS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022110451.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22475" checksum="71F476B90D16DA4D" modified="2022-01-19" version="1">MHCGKTSFQSVHFNSSDRAQKISFLHDAADIGTRAFGAAYALARYLAMDSFGSQALLHASVNRSSDSGDPEVEYRVKKVTEKFSECMHIVANEPSLALFRIQEHIRKSLPRLAECKMELGQTQQLVQGAYYDVDYAIRAVSEIQNSTHSFTSIENMLNDSIAQKRQLIAKTQAARAAKARRDSPLTLIKDETGETVNRDSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A6R9</accession>
    <name>A0A8B8A6R9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110990924</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022111696.1">
        <property type="nucleotide sequence ID" value="XM_022256004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A6R9"/>
    <dbReference type="GeneID" id="110990924"/>
    <dbReference type="KEGG" id="aplc:110990924"/>
    <dbReference type="OMA" id="WAQRLMP"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047034">
        <property type="term" value="F:15-hydroxyicosatetraenoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016404">
        <property type="term" value="F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="24">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022111696.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25382" checksum="15956D0192BC357C" modified="2022-01-19" version="1">GIGIADVNHKKGQETARHFTSQYGNNKAVFLQCDVTSDQQLEDAFKKTKQKFGQLDIVCNNAGIGDERKWRQMIDINLAAVVQGTYLARKYLSKLNGGSGGVVINIASMAGLILGPLCPVYTATKHGVVGFTRTMASFDPAFTAEDIRINTICPSFSDTSIIHKTVPPEFINSSTVRRLSDIAKLLPVSLVAEGFISLIEEDAHDKVMRVTHERGIDFHKFKKTPPMPSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XEP2</accession>
    <name>A0A8B7XEP2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal acetylcholine receptor subunit alpha-6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110973064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079218.1">
        <property type="nucleotide sequence ID" value="XM_022223526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XEP2"/>
    <dbReference type="GeneID" id="110973064"/>
    <dbReference type="KEGG" id="aplc:110973064"/>
    <dbReference type="OMA" id="DEIWTPK"/>
    <dbReference type="OrthoDB" id="5809364at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034463316" evidence="5">
        <location>
            <begin position="22"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="37"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="253"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022079218.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51636" checksum="7AC4286D660E1B76" modified="2022-01-19" version="1">MASQQFIWSLLLYALVVFVDAEASITTNDSSIFLAERRLRHVLFRSDEYDAHERPVLLSHQPVDVNVSLAMYALISLDEKEQIMTGASWFIMQWHDYRIRWDPQKYGNLRYLSLAMDEIWTPKLLLTNTASEKVENPVQESIFRALLSWDGHVTLEGPIIHITSCRMQLSEFPFDRQNCSLVFSTQNMPMPIVNLRLGPEVRIDATETTSQWRTLTLRGEAHSQTFKYLTYPKVLFSLEVERLPYHYLLNIALPSAVITLISLGVFWLTPESGEKISMAVSLLLGQAVFWLVVADSLPATGCQDTPLLLVCIECNFVVSGLAILLSVVTLGVHHRPGPLRSRFLRGLLLCTLPQLVCLRCKRRRKVGDLHGETAEQVKDAVETVKTVNMFAKEGEKPIEDFKLSSDALESQNGMDDMKLVAAVLDRIFFVIAAIVFICGNAPLFCKWIQVETALDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XFF2</accession>
    <name>A0A8B7XFF2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sacsin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079489.1">
        <property type="nucleotide sequence ID" value="XM_022223797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973183"/>
    <dbReference type="KEGG" id="aplc:110973183"/>
    <dbReference type="OMA" id="MFHFTEL"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919:SF2">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46919">
        <property type="entry name" value="ZINC FINGER, C3HC4 TYPE (RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="54"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079489.1"/>
        </source>
    </evidence>
    <sequence length="2178" mass="247490" checksum="C1055E6C584DFCA8" modified="2022-01-19" version="1">MPQSKRKAPLDSHGSKPKMRRVTQHHASKEQADRVYSQEDQEYEDDDFGQTLPPLHIYIKRVLDKYPEGGQILKELVQNADDAEAKTVVFLYDKSQHPDRQLWSDTLRDFQGPALYAYNDATFRKEDWKNIQHPEQSGKLEDLTKVGRFGLGFISVYHLTDMPSVVSGNQIGFLDPLEKHFTHDPHTNTRYKGRRGKKWRMSADLLAKFPDQFLPYLIDLFHFSKRDFRDGKLDGTIFRFPLRTSPSLISKSVFGDQDRVKELLVSFQADAEVSLLFLKHVESISVYERDHYHDRPKLTYRVQISQKDRQQVQSSRATFLGQILSKHNIQTESFVRIEKQVGKQTVENTSAYITVNILKNRSTSRRMQELIRDEDLKLLPWMGMSFQISAAGLAAEQQTGRVFCFLPLPESETTGLPVHIHGYFGLGDNRRSIKWPDRESQHDNKALWNKLLLEEVFPELYAKVVLAAVRRSKDCENPIKPLDVYRGWPSIGRVNGAWLAGVKKFLQLMANEDVFYSDYNGGSWMKPSDKIYVDPEESALISKVLKFKGCPVAQPPKHILESLDWAGVCYKKVTPAIVRNMIRGDSLQFLLRDEKMQLLKYVSSEDISDLYDLSLLPLQTGEFISFRHDAKKVYIATSENPSSLIPNGGSRFAASDLPSGLMKSSVEKCTQLKYLSVYDVAPLLRETLPITWREGSDTTLPWTPGKNQQPKEEWLMELWKWMAKTFIESDLELFKGIPLIPISNNQLARLQEGTLICREQRGSSYGDLSIRLSDNICSFLESVGAVVLKQNIPTYISRHPEVCRFVSSPTATGVITVLNKLSRKIYFSRCIARLASSTKDELRTLFAQLHQLTTQQRNFLRELPIFLTSNGQYISVSMCGTAVPKDYFGLPLKKLRCQCLLLSSGKSDSLLSRLGVHIESPYELLQNNVLPAVQDKFYNDSNSLRIMTWVLERPEFDSLVTDLKFVPSLECKVKPKELFEPSRNLVAMFRGMSVFPTGRYSEGRLLNNLKRVGLKKEACITLDDILGCAMDVSQTQARGKVDIKRGSALLEHIERYPHVLQGTVTRNGICKALHEFLEDMFWVPCEALPPVNYPASAGWKGNSYKLCTPRQVGLIETALLQGSVLPLVKSEGAGEELLSVFGWSKKLDPSNYQHLQRVILHLKHASTTYRIVRGDAFVVSPMVSEIYSFLSKSESAQLRYLFDNYLKAQPWVWHGSGFTTPDKIALSHGTLGVTFTPYLRVVPEDFLKFRKFFTTMGVKETFQESVLSEVLEIVQQKYQATSVSSEQEYKTDLNLVCNILRHIVSQDKIHVDRSKILVPCRESGKRGRHLHMVHSSECLYVDEERLAKHVFAEGFQDLDKPIIHELVPNWIAHKLELQPLSHVIAPVEAVEYGYEVSGPHETTVNAIKRNLEMYKEGPGILNELIQNADDAGATEVKFLLDWRRNERTAHDLLSEGMKTCHGPALWAYNNARFSKDDITNICNIAAQSKKHQLEKVGRFGLGFTSVYHLTDVPSVVSGPYVLICDPRTTHLGSRVQPSQPGIKLDLRKELHKQTLRTYPNQFHPYDGIFGCNLLDRANFAHTLIRLPLRTDVEIDVQLQNQISDSVFDSKKSLKPLLDSLEKSASTLLLFTQNVVHVSVHELQSENVNDMKTLMSITVSAIHQLPRSISSAGDFAKQRGILKATAAYMKDRDFSLPVPETTMIVKVTLETGVCGKGAKKKPKKTTCHFIVSSCMTSGKSQQLARTKNGIKAGVLPCGGVAAKLVSGKKGLTPETTHGKAFSYLPLDVSTGLGFHVNGNFLLQPNRRQLWSKPSSDTGEFESRWNIGFMESVLLEAFFNLLKDLQALQKQSIVDARNFQCLWPRRSESESDFYPLADAFYKSLGGSSDVAPAVVFNQSKWMSCHQCIFTEWSLHDPDDLKSSIKALLNKHEYPKRCVELETDVVMSIKLAGASRCFDGNTFSIERFLSEVFFPMLKKHSDGIESDHRDRIVAHVLDQRLGERKVRDYDKLLRTTDCIPTSPNGEFLASPKELVNPTTQVGSLYDESEFRFPHGKVYRQQERLLSLSQLGMASHDLSWEDICERAETLTKRANVDHRCKTLLKLIDEKLRRCEEPTADQKRRIREAAFLPVMKKPLRYPIGWFQCGDEHASAERLFAAEHKYLLGSVQRLLERIDWGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGK1</accession>
    <name>A0A8B7XGK1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110973081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079252.1">
        <property type="nucleotide sequence ID" value="XM_022223560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGK1"/>
    <dbReference type="GeneID" id="110973081"/>
    <dbReference type="KEGG" id="aplc:110973081"/>
    <dbReference type="CTD" id="10920"/>
    <dbReference type="OMA" id="MRIPDKL"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000011">
        <property type="entry name" value="COP9 signalosome complex subunit 8-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="3"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022079252.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="20786" checksum="E6CB4ADC2FE529E1" modified="2022-01-19" version="1">MAAALDAEKLLVQCEAIELEAPGGVATPEVYSKLLALYLLNNDMNNAKFLWKRIPQPIKTANPEVGLIWAVGQSMWQRNFPATYTSLGREWSEAVKPIMEAITENIRQRMFHLISQGYTSIEADEFAAYVGLPVDQAIAAVKSEGWQYNAENKMISPQKPVAQMDQAIPSEQHIAQLTDFVSFLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLG8</accession>
    <name>A0A8B7XLG8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EKC/KEOPS complex subunit Tprkb-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110974017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081002.1">
        <property type="nucleotide sequence ID" value="XM_022225310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLG8"/>
    <dbReference type="GeneID" id="110974017"/>
    <dbReference type="KEGG" id="aplc:110974017"/>
    <dbReference type="CTD" id="51002"/>
    <dbReference type="OMA" id="IVCRMST"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022081002.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19897" checksum="1482E0845A61FFCB" modified="2022-01-19" version="1">MLTPDFAVKFQLELFPETEVCIALFKDVKNVDEIKNIIMAGEIDAALLSPKMIIDPFQVLIAANKTLHVKKHGLKMQTRNINSEVLFNLSPTNNISASFKRFGLTQEDTGLLAVTLDDASLDKMLAVESSVDGCAVSLDDLASFTDESLIKQVYKIQEEELRVCSVLDAVVSRMSGKEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM55</accession>
    <name>A0A8B7XM55_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110974508</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081894.1">
        <property type="nucleotide sequence ID" value="XM_022226202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM55"/>
    <dbReference type="GeneID" id="110974508"/>
    <dbReference type="KEGG" id="aplc:110974508"/>
    <dbReference type="OrthoDB" id="1844at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000002">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022081894.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50234" checksum="CF397BB51C5E5D9F" modified="2022-01-19" version="1">MRECLSLHIGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFSPEQLITGKEDAANNYARGHYTVGKELIDLVLDRIRKLADLCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQISTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYTPTISAEKAYHEQLTVAEITNSCFEPANQMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVDSADGEAEGEEIDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMM4</accession>
    <name>A0A8B7XMM4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABC-type xenobiotic transporter</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110974232</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022081417.1">
        <property type="nucleotide sequence ID" value="XM_022225725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974232"/>
    <dbReference type="KEGG" id="aplc:110974232"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18598">
        <property type="entry name" value="ABC_6TM_MRP7_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18605">
        <property type="entry name" value="ABC_6TM_MRP7_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000113">
        <property type="entry name" value="ABC transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000037">
        <property type="entry name" value="ATP-binding cassette subfamily C member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF330">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="561"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1033"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1134"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1217"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="339"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="689"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="963"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1314"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="665"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="911"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022081417.1"/>
        </source>
    </evidence>
    <sequence length="1557" mass="172999" checksum="CCCE362E94BF833D" modified="2022-01-19" version="1">MTAKVDLQDFCWPPNNDSFFWADKAYSYCKELPDFDVTSYALLAVASGLSIGHIQHSEHKNLKRFWALRARFALSIVSSFLPVIGVILNLTHSVKLIAPFPSVRDGCAFFAWAAHALYLLKLLKARQKLVRGYLPVLFAWTLSLLSTVVRVAKVTGYIAQKDQLELEEVGRILTFVEFALQLLYLVLLLPSHNQKQVAFEGNHDEECSVVSDLGVAAEEAGFLSKLLLWWIRPLLKQGAQGKLRNADDVFRLPKYLQTLNVQDYFGRILNGELADRVTGNREADDLSKLEKKTLAGCAFSKEQIFSVFGWRSRGKSESTLSERPTLLRALVRAFGVHFIFLGVAKFCLYVTRYAGPLLLNALVTFIEDGEEPVQNGLLYAFILSLSTLLHAFVSIHYHYQTFKMITRMRAALVTTIYRKALVVSSTAASRFTTGEITNMMSVDVDRVKGICWGLHESWGIPFQMTVSLILLYQQLGLSFLAGVVFAVLMAAVTKWPSSKMYKFYEGLMKHKDSRIKLMSEILHGIRVIKFYAWEKHFMRKIEELRDSELGRLKQLKYLHAVFVYIWNSANILIAVSSFAAFVLLGNQLTAAKVFTSLTLFNMLIGPLHYLPWLINDVIESRVSLKRIQSFLDLEELDPSTYYSSQGMEDPNSYLEIKQGSFQWDHPQKAEDTAADEGSKETSKSTEKDTDGMDLEKKGTGVLKLSNLNLCVGRGRLVGVIGCVGSGKSSLLSAITAEMTHTGGSISVSDLMSGFGLVPQEAWVQHATLRDNVLFGTEFIAKRYRAVIEACALKDDIKSLPAGDLTEIGENGVTLSGGQKARVALARAVYQDKDLYLLDDPMAAVDAHVGAHIFSQCIMGLLKNKTRILCTHHTKYLQEADLVIVMEGGVIRNAGHPTVILENKDLLAAAQHNGPGVREGGNSPGEEEEEAELWTRKEDGKLVEEEEQVTGMVKFKVYQAYWNAIGCSLATSVLVAMVLTQASRRIADWWLSYWVSHSHSYEAFNSSSSTENITSTHAEVPMTEMNLTGADNPMFYLGIYGGIVGANSIFMLFRAFLFAYGGLCAAKTIHNGLLSSIWKAPVSFFDTTPIGRIINRFSSDTHTIDNNLPDVLCRFLSFLFGTVGTLVLVCYGIPWFSVVLIPIFILYSCIQNYYRKTSRQLGRIESVTMSPIYAHFSETLAGLPTIRALRATERFRLENAAKLEANQRIRFCGFSVRIWLAVCLDLLTAVIIATVAVTAVLGRQYQTLSPGLVGLVLSSTLSISYHLQEVVAVFTELEKKMVSLERVEQYIKDLPSENQQGRLQVAPSWPQHGQVSFKNVSFAYRPSLPNALNGVTFDLQPAEKLGIVGRTGSGKSSLFQVLFRLVEIQSGQVTIDGVDIAHLSLEELRSKLAIIPQDPFLFIGSIRENLDPTGRFSDKDLWVVLEKCHLQSVVESLGGLQAQAGEKGRKFSVGQRQLVCLARAMLTGAKVLCIDEATASVDMATDRLLQRTIRQEFAASTVLTIAHRLDTIMDSDRVLVMSSGQAAELASPKELLEDPTSLFYGLVNKGNNSTDRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMT8</accession>
    <name>A0A8B7XMT8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox protein HB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110974644</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082139.1">
        <property type="nucleotide sequence ID" value="XM_022226447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMT8"/>
    <dbReference type="GeneID" id="110974644"/>
    <dbReference type="KEGG" id="aplc:110974644"/>
    <dbReference type="OMA" id="ITSWDAR"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000193">
        <property type="entry name" value="Ultrabithorax, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050296">
        <property type="entry name" value="Antp_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659:SF4">
        <property type="entry name" value="HOMEOBOX PROTEIN ABDOMINAL-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45659">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="177"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="179"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="238"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022082139.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30631" checksum="5C481ABC407243FD" modified="2022-01-19" version="1">MNSSSYFVNTLFSKYQPGEGFYPSGYELPSCAYSKTQKTSYNSGNLGGGMNGVSNHHQQPPGYFSTPATSANAFHGSYEPHSVNAASNVYGTLNQSAASPITSWDARLPSYGTSWPGNTAELDSSYNLKEHSGTMGVFSPSSQSDVLNNNCHNSMVSGSSSNFPWMNVAGTVAGMDVGRKRCRQTYTRYQTLELEKEFHYNRYLTRRRRIELSHQLALTERQIKIWFQNRRMKYKKENKKEGTGSPEGEKSEAELGGVTARIPGAEERGNVHGVGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPH9</accession>
    <name>A0A8B7XPH9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Liprin-alpha-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110975002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the liprin family. Liprin-alpha subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082728.1">
        <property type="nucleotide sequence ID" value="XM_022227036.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975002"/>
    <dbReference type="KEGG" id="aplc:110975002"/>
    <dbReference type="OrthoDB" id="2132119at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09562">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09565">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09568">
        <property type="entry name" value="SAM_liprin-alpha1_2_3_4_repeat3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000003">
        <property type="entry name" value="liprin-alpha-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000004">
        <property type="entry name" value="PTPRF interacting protein alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057892">
        <property type="entry name" value="LIP-1_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037620">
        <property type="entry name" value="LIP-1_SAM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037621">
        <property type="entry name" value="LIP-1_SAM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037622">
        <property type="entry name" value="LIP-1_SAM_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029515">
        <property type="entry name" value="Liprin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587">
        <property type="entry name" value="LAR INTERACTING PROTEIN LIP -RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12587:SF20">
        <property type="entry name" value="LIPRIN-ALPHA, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25526">
        <property type="entry name" value="LIP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="958"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="9">
        <location>
            <begin position="1131"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="745"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1221"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="245"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="470"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="629"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="814"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="848"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="889"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1225"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1254"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022082728.1"/>
        </source>
    </evidence>
    <sequence length="1281" mass="144518" checksum="450E31C5BADB9429" modified="2022-01-19" version="1">MMCDVMPTISEDGSQRGSSYGDDANFEQLMVNMLDERDRLMESLRETQEALGGADLRIGELERERDLLHKQLSTGLPREFATLTKELNQSREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQASSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRLALERVSSLEEELERSHQENLALREQNSIRNQNGEVQSLSSVNHEDVASTNRRNSKRLSNGSIDPDDDASRVLELQDTLERQNQELSQSKDRASELMLRVASLEESLAKTQKEVLRAQESASKFQRDAREAMCQKEDMEERIATLEKRYLNSQRETTSLHDLNDKLESELANKETLLRQTEDKMRHYQEKLELSEQKLSQTLRKAEELPNVEAELAERMAALSQQAEERQGSAEEKLRQLRSELEECKQELERARERERMNEEHNKRLSSTVDKLLSESNERLQLHLKERMAALDDKNALTHELEKVKKFMDEMQLESKRNRDELERYKVELKITKERLAQQGAQGSTSSISEMGPSQGVPDVVIANATQSSGSLEDEEYDMAGVVRRQQPGRLQALKSDPTKVNTLNEQEWEKAEQASVLANIAQAFESDEGAGHSEDESESIFGAVDMLSPQGHTDAQTLAAMLQEQLDAINNEIRLIQEEKFSTEQRAEEIEHRVGTGSVDNFDLFQSSTGRSRYYWSAEPRNLTRSLPGSMVMHTTTEHERVSPPGSEDSTPRIERRGNASVDALGSQYSYSQPQIPSLAGLDGPIEEGEGSGATAQRKGVYSRSMSLSESQLHYWQRGRKPLRGTEEVTEEEKSQQPRTTPLSPRSQQLERIAAAITAQGNEQEQRRGSLDSSHSTPSPQSSNNSSQDSLHKQQAKRPGLKGSLGRLFGGKRGDKASPLRRGKEGNYSESEKAQYMDDTSSQDSLVVGAGGQQRDFDRRKKKKHELLAEAIKAGTPFALWNGPTVVAWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTTLAFGEMNHEWIGNEWLPCIGLPQYRSTFMECLVDARMLDHLNKKDMRGQLKMVDNFHRTSLQYGIMCLKKVNYDRNELKRRRDQSANEIKDVLVWSNDRVIKWIVSIGLREYANNLIESGVHGALIALDEAFDHQALALALQIPTQNTQARQLLEREYNNLLALGTERRMEEDVGSKFKRGPSWRRMLKLKDGTSPKGKEGAAPGATSQDATAPGSPIQRSNAAPKPQGSTTAEGDRPAVQTYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ59</accession>
    <name>A0A8B7XQ59_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110974762</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082312.1">
        <property type="nucleotide sequence ID" value="XM_022226620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ59"/>
    <dbReference type="GeneID" id="110974762"/>
    <dbReference type="KEGG" id="aplc:110974762"/>
    <dbReference type="OrthoDB" id="9820562at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022082312.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="49939" checksum="2DF596B29847EF0F" modified="2022-01-19" version="1">MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKHVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAEGCDCLQGFQLTQSLGGGTGSGMGTLLISKIREEYPDRIMSTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLTTPTYGDLNHLVSITMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALSVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGDFDEEEEGDEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR39</accession>
    <name>A0A8B7XR39_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110974859</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110974859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082460.1">
        <property type="nucleotide sequence ID" value="XM_022226768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR39"/>
    <dbReference type="GeneID" id="110974859"/>
    <dbReference type="KEGG" id="aplc:110974859"/>
    <dbReference type="OMA" id="ITICWGR"/>
    <dbReference type="OrthoDB" id="737510at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034482098" evidence="4">
        <location>
            <begin position="20"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="576"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022082460.1"/>
        </source>
    </evidence>
    <sequence length="695" mass="75381" checksum="B91C5E550E6F468A" modified="2022-01-19" version="1">MVRCPGILLQLLIICPLTAHGGQGGAGNSGDVEFRVRRATTDLTEAQHQAYVARHNQLRAQVSPTATNMEHMIYDASLAATAQAWSQKCDFRHSKNHPSLSLTLTATYGENYGENLGVTTSASQPDVSDILQAWFDEVVDYSYDDNSCQAGKQCGHYTQVVWAESNVVGCGVHHCPGGVTVTDSPNPEYIFNGQAAWMVTCHYSPAGNLQGAKPYMSGPSCTQCSSGVGYCLNNTCASQSVCSAAGGCECRARCLNCGNLNETACRCECLSGWLGADCSVECADADSNCKTVALAPRLNCPTWREQCPVACSVCTPPTNQDCVGPSTVTPSIGVPPTASPSTVQPSTTSPPCELVCENGGTLNSNDCACTCASGYQGTTCQSITAQTQFIVLFRLRHNIASFSRIRTALLRSVAGVLNVFCASRDNYQRCCPNDVLRLTTGSEQLPNFIDEGNVFLAAGYPNPVTSEVYEVGVVVLGVQSPLCTALRIGQRKRRSATDGSQERIRIKRQSDNFLDPDLVNDAITASLDDIRQQLSAVDNTVDLLSVEPADPNPTESPATTSTTTSTPTSTPTSTNYIIIIVVVGVVALLIILSIVGLGCLVMFRHGMARQYKIRPRYSYEDRPRNVHNRALDFNYDPTYNRAGYEYPHTNPYVRKPIIDNGYALPATYEQRLWRPRSNILTSNEPPRMPDDYFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRC6</accession>
    <name>A0A8B7XRC6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110974903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110974903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082541.1">
        <property type="nucleotide sequence ID" value="XM_022226849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRC6"/>
    <dbReference type="GeneID" id="110974903"/>
    <dbReference type="KEGG" id="aplc:110974903"/>
    <dbReference type="OMA" id="WSARDSD"/>
    <dbReference type="OrthoDB" id="10521296at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022082541.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="24687" checksum="009DF60FC9DB2F7B" modified="2022-01-19" version="1">MAPSRAVGGCLIFLFVGFIWIPIWIVYSSGSGVAITVLAADVVVETETSTQYLLSAQSEGNDKPTLPEKFSEMLKLTRRENDKGQAATDTTLPTGVVTNQPINAVGIPTTHTQTNHEWSSQISSGDGATISSNQSNAERNKKAGSNDNACNRMADLQKTTLHWIKTLCEALKRQPVIVRVVLLVTVGLSSLLFTVIAYKLLCPRLYRREGIEKLYDIEDSWLLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XS89</accession>
    <name>A0A8B7XS89_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sentrin-specific protease 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110975493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083723.1">
        <property type="nucleotide sequence ID" value="XM_022228031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XS89"/>
    <dbReference type="GeneID" id="110975493"/>
    <dbReference type="KEGG" id="aplc:110975493"/>
    <dbReference type="OMA" id="TRETTRY"/>
    <dbReference type="OrthoDB" id="1939479at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000001">
        <property type="entry name" value="Sentrin-specific protease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF141">
        <property type="entry name" value="GH15225P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="551"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022083723.1"/>
        </source>
    </evidence>
    <sequence length="743" mass="84727" checksum="3C31591F480D245D" modified="2022-01-19" version="1">MPMVSKLTSAFRTWIGSDGSQSSPVPRKRTWASTNKQHAEQDILETPEPKRIKHNHENVTSPIGKMANWIKQKASTFGENYFFRPVGMQNGYDNHMVNSSHEPQEANTKPDLRRRPIQRSPMATTSKDPIMGKTTLQEDGQKLPNGPDVRRKDNHSLRGGDSGSSPKPVQQFTDAPPSFSSHSSASSKARNQSRAKDRQTISTHANHSSQSQAPSSTLPSSTIAPPTVGRSYTSVNEKLFSRPPIRQSSVSSDGSRSHSTATECVRLDQLQQYQQLLQQFTTANVSVLSPTSSSIRVRNSGTRETTRYLAKRTQQESTELGSVIERPRIPANRSLHRTRVLPHQYESRQEVREAARQRLHAPVTDLSPSATPYTSRHTVATPGQPDFSVRSESPIIVSIKPAPQRSASRDLSQMTSFERSLTATPCAMTDWVKDLKERFESSVRLQHRNIEREKAALSLYKQQRDEQAARVSKKITEDMKLAERRVAVIEEPPTPEVSEEEDVEEIEEIEDEEEEEAEEELPEITDDMRAEIENALRPTPSSQVLVEGFRIQLTRNDMHTLYGLNWLNDEIINFYMSMLVERGGELGQTKLHCFNTFFYPKLLKEGHAGLRRWTKKTDIFAKNMILIPIHLGMHWCLAIIDFRKKSIEYFDSMGGENKQCLNALWDYLIAEHRDKKGSPYDMTGWRSSCRRDIPQQLNGSDCGMFACKFADYISRDKKITFTQHDMPYFRKRMVWELLHKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XT40</accession>
    <name>A0A8B7XT40_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">ERO1-like protein beta isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110975179</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083096.1">
        <property type="nucleotide sequence ID" value="XM_022227404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XT40"/>
    <dbReference type="GeneID" id="110975179"/>
    <dbReference type="KEGG" id="aplc:110975179"/>
    <dbReference type="OMA" id="CYKDRLH"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034750678" evidence="19">
        <location>
            <begin position="31"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="416"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022083096.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55554" checksum="0BF07147DAE52914" modified="2022-01-19" version="1">MGESNIVYVMKFILLSLSFLCLLFTVLLDAQKHNKSGALHPCFCELNGQVDDCNCKVESVASFNNLKVYDRLQNLLTRNYFKFFKVNLDKKCPFWPDDGTCALESCAVCPCTDEQVPCGLKDEPGIPHGKEKYLKESKAGGDADGSCDSRSDEEIRLSALDTTISEESEAAFKTWTEHDDMAVDFCEVDDEQSLGMKYVDLTINPERYTGYKGQSAWRIWNSIYNENCFKPNEPANSEGYQTLLTDKSVRVALHTLTGGCKKMCLEKRVFYRLISGLHSSINVHLCAKYLLSGGIFGVETWGPNVDEFKQRFDPQTTDGEGPVRLKNLYFTYLVVLRAIAKAAPLLEAELFYTGEAKEDEQIQDDVEDLLQTIKQFPNHFNESTMFQGDKLQAKRLKEEFRNHFLNISRIMDCVGCDKCKLWGKLQIQGLGTALKILFSSPDSLKLRRREIIALFNGFGRLSSSVHEVREFQILLGGGTSGNAKMASSKSPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVM7</accession>
    <name>A0A8B7XVM7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MORN repeat-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110975813</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084307.1">
        <property type="nucleotide sequence ID" value="XM_022228615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVM7"/>
    <dbReference type="GeneID" id="110975813"/>
    <dbReference type="KEGG" id="aplc:110975813"/>
    <dbReference type="CTD" id="254956"/>
    <dbReference type="OMA" id="NGRMEGK"/>
    <dbReference type="OrthoDB" id="300500at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042814">
        <property type="entry name" value="Morn5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46437:SF1">
        <property type="entry name" value="MORN REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022084307.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20047" checksum="3891B2B56DE306D3" modified="2022-01-19" version="1">MEYTGSSYEGDYKNGRMEGKGKYAFPTDTKYEGEMKDGMFHGQGTLYFPNGSKYVAKWENGIAVDGKYTFADGLEFDEPEWLYCDGYDRRFFTEICDGLKPAGRSQLTNRIPPRDIPEGCYDTGDGFYNPNTRVIVDYNHKFLRNADDDEHAWIIRTCRKGWDEIVGYQAKPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVY4</accession>
    <name>A0A8B7XVY4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC110976235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085024.1">
        <property type="nucleotide sequence ID" value="XM_022229332.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085025.1">
        <property type="nucleotide sequence ID" value="XM_022229333.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085026.1">
        <property type="nucleotide sequence ID" value="XM_022229334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVY4"/>
    <dbReference type="GeneID" id="110976235"/>
    <dbReference type="KEGG" id="aplc:110976235"/>
    <dbReference type="CTD" id="9443"/>
    <dbReference type="OMA" id="IHDSYSM"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022085024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022085025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022085026.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26777" checksum="FA03AABC0562B3DD" modified="2022-01-19" version="1">MAESQNVSSLPLPPMQYVNNYTDERVKNGTAPKPPTPVSENYNMFGAVFTPDDVIIRSLESQNLRRLHPKVFDHRKELKKINHSILFNFLDMLDVLVVAPGSKKREEKIEDIKLLFIHMHHLINEFRPHQARETLRVMMEVQKRQRLEAAERFQKHLEKVTEILQSCFGSLPDNMGHIDSKIAARMEPQAEEVSKATEGDSAEKQDEANGQKELEVSFYHKDKLMCNLVDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWB8</accession>
    <name>A0A8B7XWB8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">N-glycosylase/DNA lyase</fullName>
            <ecNumber evidence="5">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110976313</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022085164.1">
        <property type="nucleotide sequence ID" value="XM_022229472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWB8"/>
    <dbReference type="GeneID" id="110976313"/>
    <dbReference type="KEGG" id="aplc:110976313"/>
    <dbReference type="OMA" id="GYAQEYL"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000006">
        <property type="entry name" value="N-glycosylase/DNA lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.40:FF:000001">
        <property type="entry name" value="N-glycosylase/DNA lyase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000005">
        <property type="entry name" value="N-glycosylase/DNA lyase OGG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="17">
        <location>
            <begin position="185"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="365"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022085164.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="45816" checksum="52C5E52323E86E41" modified="2022-01-19" version="1">MANIWRSLPCKISELRLDITLDCGQSFRWKEIQPGMWRSVLSSKVWTLRQNEDEILYQVYEDSSSSLEDSEKEEILEEQKPEKDRQKEDHIVTGKNSKSNHTRNNSKQENVAITNIEEEKIGDGISTDAMFSSILKDYFQLNISLEKLYKTFKAADANFTKVCPGFPGVRVLRQDPTENLFSFICSSNNNISRITGMVETLCSTYGEEIAILDDRPWHAFPSVSALARDGIEQELREKGFGYRAKFINQTAKYIKAQPEGWLEGLRQLAYEEAHAELMKLPGVGAKVADCVCLMSMDKMDAIPVDTHVWQIASRDYMPSLNKTKSLTDKVYKEIGAFFRELFGEYAGWAHSVLFSADLKKFQQKAAGVNSPEKKQSKRQDYGDAKRVKKEKTGAKKIKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXF1</accession>
    <name>A0A8B7XXF1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085558.1">
        <property type="nucleotide sequence ID" value="XM_022229866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXF1"/>
    <dbReference type="GeneID" id="110976530"/>
    <dbReference type="KEGG" id="aplc:110976530"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF63">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085558.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="13013" checksum="928D72DD86012556" modified="2022-01-19" version="1">MGQQVYFAYEETGFWMRVCCQSGRGFFLHIRNNFGQEVIRVERQFKCMAGGCWLANLDCCSWEVTVESPPGNPTGRVKQGITCTLRWILTHLSRIVGMKVRVRPSPHWQRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXV7</accession>
    <name>A0A8B7XXV7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">CD2 antigen cytoplasmic tail-binding protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110976601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085724.1">
        <property type="nucleotide sequence ID" value="XM_022230032.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085725.1">
        <property type="nucleotide sequence ID" value="XM_022230033.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085726.1">
        <property type="nucleotide sequence ID" value="XM_022230034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXV7"/>
    <dbReference type="GeneID" id="110976601"/>
    <dbReference type="KEGG" id="aplc:110976601"/>
    <dbReference type="CTD" id="10421"/>
    <dbReference type="OrthoDB" id="331341at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.40:FF:000005">
        <property type="entry name" value="CD2 antigen cytoplasmic tail-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039905">
        <property type="entry name" value="CD2BP2/Lin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138:SF3">
        <property type="entry name" value="CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13138">
        <property type="entry name" value="PROTEIN LIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="292"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022085726.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40006" checksum="2B01337655C83BBD" modified="2022-01-19" version="1">MAERKVRFAEKDTADKDAEPASDKGWNRTFSKKHTLDSDEEDDEKEESKYELHQDDVEGAEDATLASEGGVRITPFNLREEMEEGRFDAHGNYFEKKEKQIQDNWLDNIDWMRVSGKGGEEKVGEDDYLPDSPEPEPGRPEIKILADIVSFLKPRETIATAVRRLGGGKKAKGVAATRKWGPKKARMEEAEDGDKAQGVDKESMLKLTEFVDELVASGNYEAYQYTYEKITHLLKEEEGRSKKEEDIFDMFGDEPVKEKITTGGPKASKDANGSGSKEASGSNPASDLDPDKTYWEYKWENKEDADKYGPFESEQMQDWVDQNYFSDGVWVRKVGSGGQFYDSKRIDFDLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY14</accession>
    <name>A0A8B7XY14_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein DDB_G0290685-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084671.1">
        <property type="nucleotide sequence ID" value="XM_022228979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XY14"/>
    <dbReference type="GeneID" id="110976038"/>
    <dbReference type="KEGG" id="aplc:110976038"/>
    <dbReference type="OrthoDB" id="10644939at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034588952" evidence="2">
        <location>
            <begin position="25"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022084671.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="69238" checksum="83AD9E2A667AA05B" modified="2022-01-19" version="1">MCGHSWTLGIFVLVLLLTVRWSQARSLPLSDGDEEAEAGNEVPKMTKYDCVLLIFKDPFELPDCVNEFFKEPSSLTMISELRQELMQSDSHEEAEIEKAAGANEEGDNDVNVLTKRVDEVADVNDQLGEDLRMLSRNAQPVKVEIMDTDADVTTDQDDSDNDDSYGDKKGEEGVQGEEEVVGGNEDEDDEDDDDDDDDDDDDDNDDVEGELLKQGDETGNKSGDDGYEEEDEEGLGNEVIDEGDDDDDAEQEVNKEDKEGVVELKDQTADDDEDDDEDDDDEDANKGGKEETAGGEIQDGDDDDDDDNDANGDEKEPSEIDKEEAEEETVTLVSKIYNMLQALVTQEKINDGGDDDDDDAEADSNGQNELGTTGDGDDDDDDDDDNDEEDEDGKWMNGSQKVEQQDDGVDDGDEDDDDNGDDDEAENKEEDTNIITETLENDADGDDDADDDVDDDTDPQNGEGTDIITEKLENDGEYDGDDDDDDDDDDNEGNVITANKEIADVDDDDGDDDNDDDDADNEQDDVKEEEDVKTSKTDMEQELEEISRLQNVEDAAEETPDDDDDDDDVDGDALDQPEKTEGEKQTETDLEKELLEALTKTKNDQDVVDEDDFIGQLQHVADKSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y099</accession>
    <name>A0A8B7Y099_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110976600 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110976600 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110976600</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085719.1">
        <property type="nucleotide sequence ID" value="XM_022230027.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085720.1">
        <property type="nucleotide sequence ID" value="XM_022230028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y099"/>
    <dbReference type="GeneID" id="110976600"/>
    <dbReference type="KEGG" id="aplc:110976600"/>
    <dbReference type="OrthoDB" id="25840at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000025">
        <property type="entry name" value="DNA repair protein XRCC1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002706">
        <property type="entry name" value="Xrcc1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370:SF4">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01834">
        <property type="entry name" value="XRCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-repair protein Xrcc1 N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085720.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="80603" checksum="F183D9EF03D7F394" modified="2022-01-19" version="1">MAPVRLMEVIVYSSQDSVHRADNLLDQSSQWKRWLCASGDRSGSMQAEFQLEKAAKIGYVDIGNYGSAFVEILVRKSSWSSNDYVTLIPATMLMSPMESRSGQNKCAVKMFTKAALSEESLRGKWDRIKVKCSQPYKKDAQFGLAFIRLRSLEEPKEQTQTISPGPTMTKLHSKSESTPMTDKPNGRPILSPSWKTNSSFQRQFMAVKDENNKYSDMELKARLLKMAATADTGSDKSDSLSRSAKMVLTSSNKKQQTPKRQPSSHGNSVHTPSTPSRKNNSTDSPYSASRKQLGPRRQDSDFENCYRSSSDRSQSSHGHSHPGHENSASKSSEPRCQRRASGQPRDSHSGFTHCQKEKEQTSTSKTPKKRPSNLPAESSPSKLTNGDSHRPFKQVAGKFLASLGRSLFDSKLSDIRPVLERKLGRKLSREEKHTLKQLAVERVDVLLKYGSPSTPSQPKPQPVPTTSTSQDSASSSVTDIAEMEFRNCPKCYLQFTARQITGHVLCCQGIPSAAGVAKAMDVSSTTKDPASFVPQRGRVRGRGRRGGRQRQRRSPAASEDNLPAVSSHVRTAQMPRYQREGAVAKGKCSGRATNPSSRNAASSPANSGKQQPGGFLIQPVEVSPSQHITSSPQGGKLTTQQSTSFGSSLQPSSAWPGNKCMTSNTNASLARSSFQMTPDRSDAREDTEYEETSPCPICFKSYPVEVIEIHADMCLEQTHILNEISNRQMACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1Z9</accession>
    <name>A0A8B7Y1Z9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type lectin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110977065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086552.1">
        <property type="nucleotide sequence ID" value="XM_022230860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1Z9"/>
    <dbReference type="GeneID" id="110977065"/>
    <dbReference type="KEGG" id="aplc:110977065"/>
    <dbReference type="OMA" id="ENAFMAT"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034055882" evidence="1">
        <location>
            <begin position="16"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="33"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086552.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28076" checksum="7BA7BF5FA8045372" modified="2022-01-19" version="1">MITVCLLAIFSGVAGCSTCSPPAGACPAGWLKWRCSCYLLRDTFASYDDSHKACQERGAELAAPHSLRENEFFASLASRTQPQQMWIGCNDREAAYDWVCEGQERGKVFTRWDSGSPDHVHDSPTSTDHCTMMLAFRGTVNFGRWFDGRCMSKSKSLCVKRMKVLSHRLFSFVVSNPSPRCLLDRVIDQSVTKSYASCASACIATPGCLSFNIRVTEQGGRKLCPLNGGYQPDDPALNIQPLGPTCVLYEPYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2D4</accession>
    <name>A0A8B7Y2D4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP-binding protein Di-Ras2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110977465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. Di-Ras family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087334.1">
        <property type="nucleotide sequence ID" value="XM_022231642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2D4"/>
    <dbReference type="GeneID" id="110977465"/>
    <dbReference type="KEGG" id="aplc:110977465"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000303">
        <property type="entry name" value="GTP-binding protein Di-Ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022087334.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="28320" checksum="4296DACA85C0C414" modified="2022-01-19" version="1">MSGSTMSSQDIMERFMRLRVAWSKLFAVRAFISLANASNQLPRDRSIRLRVMPEQSNDYRVVVFGAGGVGKSSLVLRFVRGTFRETYIPTIEDTYRQVISCNKNVCTLQITDTTGSHQFPAMQRLSISKGHAFILVYSITSRQSLEELKPIYDVISEVKGDIDGIPIMLVGNKCDDANREVTIQEGMEQAKSWGCAFLETSAKTNYNVKELFQDLLQLEKRRTMSLHLETKKSKSQKRREKLKGKCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4P6</accession>
    <name>A0A8B7Y4P6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-2-macroglobulin receptor-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087512.1">
        <property type="nucleotide sequence ID" value="XM_022231820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4P6"/>
    <dbReference type="GeneID" id="110977578"/>
    <dbReference type="KEGG" id="aplc:110977578"/>
    <dbReference type="CTD" id="4043"/>
    <dbReference type="OMA" id="QEFEHHQ"/>
    <dbReference type="OrthoDB" id="5817428at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050750">
        <property type="term" value="F:low-density lipoprotein particle receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048259">
        <property type="term" value="P:regulation of receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.10">
        <property type="entry name" value="RAP domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038003">
        <property type="entry name" value="A2-macroglobuin_RAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010483">
        <property type="entry name" value="Alpha_2_MRAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009066">
        <property type="entry name" value="MG_RAP_rcpt_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036744">
        <property type="entry name" value="RAP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16560">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16560:SF2">
        <property type="entry name" value="ALPHA-2-MACROGLOBULIN RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06401">
        <property type="entry name" value="Alpha-2-MRAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06400">
        <property type="entry name" value="Alpha-2-MRAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47045">
        <property type="entry name" value="RAP domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034405535" evidence="2">
        <location>
            <begin position="24"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin receptor-associated protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin RAP C-terminal" evidence="4">
        <location>
            <begin position="136"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022087512.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="40158" checksum="82FDC1C38360286E" modified="2022-01-19" version="1">MTSVGLTFVVICALASICGVAQAKGKYAESANTQDNVSDRFRTRVVQQVWEKAHRMNFPPKKLEELSHVLQQHDVKMLQLKKHQQDGGDPEGETEALLRRRLSDIMRKFGIIPPEGEDPRRAKDFGQKRDMTGEEFKDHRLNKLWMKAQQSPNFNTLELDQLKEELTHHQEKVNQFEQLSSQLYSDRTRDANRVDRDKKTMDPDERSVLELDLKIQHRELTNDFQRLSSKLVPDQHKGEFQEPRVVNLWREALFANFTEEELESISTELKHFEAKLTKFEDLQVQSLHAEKEYRVAKKLGETTDAKKHKSLRDEARELGNSVHTFMNDMRGRIQRNRDRADEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y513</accession>
    <name>A0A8B7Y513_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">DDB1- and CUL4-associated factor 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17" type="primary">LOC110977270</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat DCAF12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086935.1">
        <property type="nucleotide sequence ID" value="XM_022231243.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086936.1">
        <property type="nucleotide sequence ID" value="XM_022231244.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086937.1">
        <property type="nucleotide sequence ID" value="XM_022231245.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086938.1">
        <property type="nucleotide sequence ID" value="XM_022231246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y513"/>
    <dbReference type="GeneID" id="110977270"/>
    <dbReference type="KEGG" id="aplc:110977270"/>
    <dbReference type="OMA" id="GGEQYGW"/>
    <dbReference type="OrthoDB" id="9610195at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056151">
        <property type="entry name" value="Beta-prop_DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF16">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23760">
        <property type="entry name" value="Beta-prop_DCAF12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="12">
        <location>
            <begin position="46"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DDB1- and CUL4-associated factor 12 beta-propeller" evidence="12">
        <location>
            <begin position="264"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022086935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022086936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022086937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022086938.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="52060" checksum="6ECE52DC33AB7928" modified="2022-01-19" version="1">MEFDYEHFSEASYEDKMSVFQYTQKRQIGKPPRISRKLDSFAARKLPYLLKEKEIPLGTTNKVFASEWLSDRQIIFGTKCNKLIVLDVYTGQQCRLPIIKSRTGRVYENCVYTQSLSFGGIHSIATNPSKTLLATGADNPDNVALYKLPSFDPVFLGENCHEDWIFAIAWLDDQYFVTGSRDSSIALWSTTETQNIEEKTLSKNVYLSKGRWRESSVRHYSEDEESWSSSPERLDSYQSGSEDSAYSSVEDVSNHTCLKDVARKYCQDKDKVRALQVNEFKKDLAVLTSNGFIYTIDMETFDQLDVEHLTYCQENVCIALSRDYSLYAVGSQSHITFLDPHSLKSITSICSKERGSGVRSVSFREEIVTIGTGRGTIRFFDIRAGRYLPDEARPKKECTLRTGQGHLNRDDMYFQHFYGEQHGNAAYTHAYDKSGTRLFVAGGPLPAGLSGNYAALWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6Z5</accession>
    <name>A0A8B7Y6Z5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110977599</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110977599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087556.1">
        <property type="nucleotide sequence ID" value="XM_022231864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6Z5"/>
    <dbReference type="GeneID" id="110977599"/>
    <dbReference type="KEGG" id="aplc:110977599"/>
    <dbReference type="OrthoDB" id="6152807at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061343">
        <property type="term" value="P:cell adhesion involved in heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007508">
        <property type="term" value="P:larval heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395:SF22">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33395">
        <property type="entry name" value="TRANSCRIPTASE, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022087556.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="20200" checksum="D3737926B3E7E244" modified="2022-01-19" version="1">MLDLIVCNEPNWTWNICKGPGLGNSDHDSVHFRIVTTSRHQFLHHTFHQFHKADKQDFHTILQCIPWQLFLEDDVDETWENFTSLIHAAVKDVVPIATSKGHRWSPWIMNDIVKAARKKNQAGSRETEIPVRTQVTATLTVMRSKNSGWRKQQVLNVIAVWLVPCLWARLLSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7P7</accession>
    <name>A0A8B7Y7P7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110978037</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110978037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088365.1">
        <property type="nucleotide sequence ID" value="XM_022232673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7P7"/>
    <dbReference type="GeneID" id="110978037"/>
    <dbReference type="KEGG" id="aplc:110978037"/>
    <dbReference type="OMA" id="KAPGHWK"/>
    <dbReference type="OrthoDB" id="382863at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053347">
        <property type="entry name" value="Axonemal_MT_stabilizer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37404">
        <property type="entry name" value="HCG1796489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37404:SF1">
        <property type="entry name" value="HCG1796489"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022088365.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36763" checksum="ED9614EA6C2C6855" modified="2022-01-19" version="1">MPPERRFDLHKTSSGRGLDYKPEYYFPASDFKTTVSNPLPPELAKQDEIIKPYTTTTGETHDFKHHDAILGNPQHQKAPGHWNIHYNKDLREKLQNRPWRKPLTMGNQESEVQSNFKGAQTQPGVDFNTIVKPQTTDLIDHHRNMPAPPKDKLPKYNPSLVRDDGALQLLDPYVPTSHRVHKRFSRHELGGYPKKDAATYWRCEDYPQAWGHGTKHNPLPKNSVPRECPPMRDDMVFKTPIREPVRWPEKFPRVPHNGIKSIMTTSYVPPSDPKNRELFSCPVDTPWVIPRSGPKETFSVPSMYNTEYQTYASGKPISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9C7</accession>
    <name>A0A8B7Y9C7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110978853</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089844.1">
        <property type="nucleotide sequence ID" value="XM_022234152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9C7"/>
    <dbReference type="GeneID" id="110978853"/>
    <dbReference type="KEGG" id="aplc:110978853"/>
    <dbReference type="OMA" id="GTNHYGP"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="381"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022089844.1"/>
        </source>
    </evidence>
    <sequence length="645" mass="76393" checksum="4E64E19156694024" modified="2022-01-19" version="1">MDKYTTFEEYQQLWQKRDLLNLPDEEYQGINLYHCMSENTERLKTWTTREDDIWIVTFVKAGTTWVQEIVSCIMHDGDLGAVNNKHTTFRVLFIEHDFPQQLRRLKNLPDTLQIAEETPSPRILKSHLPGQLLPPQIWEKKPKIVYVLRNPKDVVVSFFYFSKLCRNDPKVLNKTFDEFFQEMLEGTNHYGPWWDHYLYFWKRRHDENILVLRFEDIKRDLRGTVENISQFLDKKLSNETIDAITEHCTFRNMKKNKMAQLDSLFDKKDLPEGSSFMRKGKVGDWKSHFTVAQNEAMDALIRDKLHGTGLTFDFDHVVSAYSRQQHSTGTMEKYVTFEEYQQLWQKSNLMNLPDEEFEGIKLYQSMAKNVEGLKTWTVREDDIWVVTFMKTGTTWVQEIVSCIMHDGDLDTVNNKHTTFRVLFIEHDFSEQLRLLKKLPDSLQIAGETPSPRLLKSHLPGQLLPPQIWEKKPKIVYVLRNPKDVSVSFFHFSKLCRNDPKVLNKTFDEFFQEMLKGTNHYGPWWDHYLYFWNRRHDENILVLRFEDIKRDLRGTVETVCRFLGKKLSDETINIITEHCTFSNMKRNKMAQLDSLFDKKDLPEGSSFMRKGKVGDWKSHFTVAQNEAMDALIQDKLHGTGLKFDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9H9</accession>
    <name>A0A8B7Y9H9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ankyrin repeat and SAM domain-containing protein 1A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110978486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022089212.1">
        <property type="nucleotide sequence ID" value="XM_022233520.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978486"/>
    <dbReference type="KEGG" id="aplc:110978486"/>
    <dbReference type="OrthoDB" id="10039052at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01274">
        <property type="entry name" value="PTB_Anks"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09499">
        <property type="entry name" value="SAM_AIDA1AB-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09500">
        <property type="entry name" value="SAM_AIDA1AB-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033635">
        <property type="entry name" value="ANKS1/Caskin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041880">
        <property type="entry name" value="SAM_ANKS1_repeat1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041882">
        <property type="entry name" value="SAM_ANKS1_repeat2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174">
        <property type="entry name" value="ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24174:SF1">
        <property type="entry name" value="IP14385P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="1039"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="1117"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="PID" evidence="7">
        <location>
            <begin position="1321"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="635"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="802"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="963"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1282"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="402"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="748"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="969"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="979"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1282"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022089212.1"/>
        </source>
    </evidence>
    <sequence length="1472" mass="158917" checksum="67B95AEAE33EA5E7" modified="2022-01-19" version="1">MGKEQDLLDAARTGNVVTIQKILSARPKNALSQAIAIGFRRSVAPNCQDSSGYTPMHHAVLNGHRLAVEILLKYDASPGMPDAKGSTPFHLAAWTGGTEIIRVLISHARAYCHINGQNNDWDTPLHFAAQYGHTDVVKLLLENAADPTIVNKKEEMPLDLAAQYGRLETVQLLLGRQPELLGRIPDHRSILHLAARNGHPEVIKALLAAGCDINKKLKTGSALHEAALFGKVEAVRVLLEHSPAINYRMKDSASETALQKVEGYPSKVAIEIAAMIKAHIRGDPLPPSTATPGPLRKAKELIDAEQQSTYDNVPPATAPDLPAGRHSSYTPPLVKKPARPFRPMAGAGRSANYMNVDLPAKVPPKKPARSSIGILLDKVDLSASPKAESPLVNSTCSMYDLSSAPLGSSSPASQPKSSDSEKSPPPLPDRNYYDEDVAGEYTQLRLDATKATVSASPSVPIKSTGSSFKCSAPPPTTVPPEPAVLMRASSRKKRHIYAPDPIDDDPVISSKEDVNEVRKSLVLLDHPPLLAQAPDPIPGPGPMPSSSESESFYEDLSEAYSGEVVTMQQVQSSTAPLQHLQIPAHCNSTMGSSTGSDTDADVYELLSDATTGQHENYNIPPPTRVALSSVGSALEDLSPTKGINPVPPPRRSKHQAASPRSSTPTLPMPSINNDLNGSLPTLATSSYYSDLQSSETADSDVPSSPGSCYSQPPTPDHPPPSPHTAMLGIQAKLSPQSFPRGNLLGGQEPSNQAWTSQRASVEEGSAFRPIGCRDPADSSEQASRFLETRHCLAPESSVFYSTGTNYSLADPSSGFDDRSEERQSGRRLNRPEKPSRFGFPRTGIGATPQTHFTDDSHPGPVDLHQTETGRGPVNGSHSLTHSSIADSEGYQANDEFQSITDTSSSGDTELLRQDEEDPFAGPAHRIQGLIYGSNRGSRNLSLETTSRFSLSQHMTDWSLAGSSRTSMVGENGPADAPPDGGGGGGHGGGTEDGAGAIDENSEWAQIESIMASFGAGLVRESVYIRDFQKEFEKMFEGPTKPQSVGAWLESLGMGQYENMLIANGFDNLDFMGGNILEESDLTEMGILEELHRKIILQATSALPVMKTITQEGNMPSSVSEWLRSLLLSDCIPNFLSNGITSMERAMELWELELETVLEVHLLGHRKRILASLGERRHSVGSSSNSSIPRPDSLELTTDDLELKLSSFERRKQLSSITSEQSASLDIDLFKDYSKEVTTPNKPKPLPGFSAQDSTPLANAQASAVAAMQHSDIEDYDNMATSDRMTASTSCRASDAKEAENGPTSPPVQWMHPPEALIKGCCNYTASYLGSTLVKEAKGTDSTQESCTKLRRSASHLHKVPSITLSISYLGVKFIDFKSKMVITEHEICNISCVTQDSDDLRTFAYITKDSENDKLYCHVFSVKAEDIAAEIIMTLGQAFEIAYQMLLKSRPGSTEHTRLLSNTSENDHETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA33</accession>
    <name>A0A8B7YA33_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Adenosine receptor A2a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110978986</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090103.1">
        <property type="nucleotide sequence ID" value="XM_022234411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YA33"/>
    <dbReference type="GeneID" id="110978986"/>
    <dbReference type="KEGG" id="aplc:110978986"/>
    <dbReference type="OMA" id="WLYREIT"/>
    <dbReference type="OrthoDB" id="6376512at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF424">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022090103.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="40333" checksum="389C90665015AA72" modified="2022-01-19" version="1">MNCNSFYFDSSKNEICLDNCGGMESASDIVKSTVVGTMALLIIVGNIFCVVVLWKTKEIHFISRLFMASLTATDLTFGFLVVLPVAFSSAYNKWPVNHDFMCQFHEAATSILGGALTMSLLGISIDRWIAVSKPLRYSTIVTQKRALILITVLWILPLLFRLISTPAIGAYKLQFQSDSDMCWMCTRQTGHTVYTAGVGLFMLTPFVTTLFIYARLLRIARRLARRIQPNSVPRNMDGEVFSAHAKSAITFLLITATFGICWMPFTGVWLYREITGENTHKYIVIFAEMTAFSSSWLDCLVYYYRSRAFKQTARTMIRKLCCKLRRQNTEQLSTIRTINVREANELECSTTSDWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAM0</accession>
    <name>A0A8B7YAM0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SUZ domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090299.1">
        <property type="nucleotide sequence ID" value="XM_022234607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAM0"/>
    <dbReference type="GeneID" id="110979086"/>
    <dbReference type="KEGG" id="aplc:110979086"/>
    <dbReference type="OMA" id="PACMSVQ"/>
    <dbReference type="OrthoDB" id="5373615at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039228">
        <property type="entry name" value="SZRD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31796:SF2">
        <property type="entry name" value="SUZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="51"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090299.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16910" checksum="DB3B5E7002DCE15B" modified="2022-01-19" version="1">MTSNHDGNLDNLEDDELGSWEEMEDSGVLDERLEKQLKSNQMMADRDRQSQAPIMLQEDSIRTAYQPQLKILRRPTGSDGSEDLGKESKQAVAQTKSLAEREAAYAAARRRIMGSAANSEESRQDVTLAKPSTSSTRLDVESGKRQPAKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YC86</accession>
    <name>A0A8B7YC86_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter 13-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110979397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090864.1">
        <property type="nucleotide sequence ID" value="XM_022235172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YC86"/>
    <dbReference type="GeneID" id="110979397"/>
    <dbReference type="OMA" id="AMDHGIN"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="468"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="37"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022090864.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="62648" checksum="B7D4921D2CB2FF22" modified="2022-01-19" version="1">MGKNRSARRRLKRGKDPASVAAAGLAYEPPDGGWGWLVAVGSFTEMFLTMGTLLCSGVYFTPVQEEFEVSSAELGWIISSGSTLLSATCPIGSACVKRFGCRVTSLIGGSAVACGFIASSFAGSSIHIFITLGLIAGIGSGLVFVSATVILGHYFKRRYAIVNGLAFTGPGIAIFVLPPLLDYLIKNYGWRGSLLIQGAIGMHTVAAAALFRPLPSELCYRSHRKTGSKRSNLTAASYSRIEMEEFETGCSERDETKSAIDENGNRRDDDLLKEGVTESHVDSTASITSDKEMNLSKWRGSSSSICQSPSAEIGQVRDPVPADHMAFDSESGADASESNEESVDQSDAACNGSDQSKRVRRSSSDRLSFRNNCWPLYAAAFVLVCPVSFFQACAFYSVTIHLVARTGLVGVSAHLAGMSLSALGAGSSFTRLAHGWFIHRGLVSAITAYIIALIVGVIGAFGNAVSRTYVGVMIACLVIGFSSGSVYPLVPVVLRDLVSLRGLPTTYGLAMFFDSCGVFAGGFTAGLLRDVTGTYTASFCTTGVYYSIATLFLILVFFIMRLHRGREQAEAEVVPSERLENGDYQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCT4</accession>
    <name>A0A8B7YCT4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EF-hand domain-containing protein D2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090195.1">
        <property type="nucleotide sequence ID" value="XM_022234503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCT4"/>
    <dbReference type="GeneID" id="110979040"/>
    <dbReference type="KEGG" id="aplc:110979040"/>
    <dbReference type="OMA" id="ERMFKQY"/>
    <dbReference type="OrthoDB" id="6572480at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000112">
        <property type="entry name" value="EF-hand domain family, member D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040365">
        <property type="entry name" value="EFHD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13025:SF6">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022090195.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22670" checksum="9618158909A3CA97" modified="2022-01-19" version="1">MATDELASKLARREALNEGTEEPNTDKKTLVFNPFTEFKEFSRKEIKQYETMFKTYDTDKNHFIELLELKFMMEKLGAPQTHCALKDMIKEVDEDHDGRISFREFLLIFRKAAAGELETDSGLSDLARLTEIDVDKEGVGGAKNFFEAKINEQTKLKKFEEEIKQEQEEKKIQEEEKKKRRAEFKAKQEAFKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE59</accession>
    <name>A0A8B7YE59_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Perlucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110978895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089921.1">
        <property type="nucleotide sequence ID" value="XM_022234229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE59"/>
    <dbReference type="GeneID" id="110978895"/>
    <dbReference type="KEGG" id="aplc:110978895"/>
    <dbReference type="OMA" id="CFICELD"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034488789" evidence="1">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="30"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022089921.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18091" checksum="B2CF4DC29A4CB3F5" modified="2022-01-19" version="1">MNRILQVVLFLTAVTVVLGANCPAGYYKRFGGNCYKIWAEKKRWAEAHILCGTENAHLVTLNDQLESDWVNSFFINNRRHDCGKYYWIGLTDLPNEGVWTWLADNSPVHYTKWNTGEPNNSGDEDGVQVDSELNKWNDSGAWMFSECFICELDPDAMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEZ1</accession>
    <name>A0A8B7YEZ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tumor necrosis factor receptor superfamily member 1B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979049</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090216.1">
        <property type="nucleotide sequence ID" value="XM_022234524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEZ1"/>
    <dbReference type="GeneID" id="110979049"/>
    <dbReference type="KEGG" id="aplc:110979049"/>
    <dbReference type="OrthoDB" id="9990004at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052459">
        <property type="entry name" value="TNFRSF_decoy_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23097:SF181">
        <property type="entry name" value="CASPASE-8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23097">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034630057" evidence="8">
        <location>
            <begin position="37"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090216.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41263" checksum="11BAB233D4A01B8E" modified="2022-01-19" version="1">MVSNGWRVREREHRRSLRWAKAVKILMLLFLHQAYCSEVKSLTSDASVFPQVLGHVIKPRSTSSKFIPGPDGERCILDANHIQDRRYEKEDDRGGCYCELCDFGKYAKQLCQCGGPNGTQANVTDCKFVKEGLEYMDKANKCSQPYNCSLSCGNHQFKVANCTAMSDIKCECEEGWFNPHPSKGETIPRECRVKPRCPAGQGLESHTIASTGEVSFTCQPCRDGYFQGFDNSISSCQPHRACTVQAGNSINDNICLNDDLPMNLSSNVPGEPSTLEPKELESTTGTTPTQTQPSGEPRSTQENLPDDEVQPGVWYPAGCIIALACTSCVILVVLVSYCVYIKCKKKETYMDLPTVDYNARQQQVQLHVPTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YF69</accession>
    <name>A0A8B7YF69_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110979499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091035.1">
        <property type="nucleotide sequence ID" value="XM_022235343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YF69"/>
    <dbReference type="GeneID" id="110979499"/>
    <dbReference type="KEGG" id="aplc:110979499"/>
    <dbReference type="OMA" id="ISHAQQN"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="24"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022091035.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="47209" checksum="3FC848142FB3658B" modified="2022-01-19" version="1">MGERATLVANPRPQTVTEPLYGWVVVASSHTVFILWTGFVKTIGVLLPWLTSYYHTDALALGWITAAFCATNNIAAVFGSILSVLIGSRKVAILGGVIAASGLLLASVSTSLLQFALSLILLTGSGFGMTMCICKVHLGIYFNERLALASGIVTMGVPIGLMVFPAFAELLRFTYGIQGTLIILGALSSNLIVCGALLRHYPGFRIHKLGSDRGYEPINSSQTTESPNVFAALKAHIADRLDVKLLARLDMRMLIVAYMLFSFVNDSWMTFMVSNAMSKGFEGYVATTFSISAGCSAVIFSVIQGILISSKFAGIRVVSAMATAVGSAALFLDPLLNSYLAMIVAVVMYGITLAVLNPTIVCMAIETQGRERAASAFGWMGLFSGIFRLLFGFSTGLLRDITGHYDATFILLGVMLFLIVPVLFVDILVPKCRNIVWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFJ9</accession>
    <name>A0A8B7YFJ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110979670</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091372.1">
        <property type="nucleotide sequence ID" value="XM_022235680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFJ9"/>
    <dbReference type="GeneID" id="110979670"/>
    <dbReference type="KEGG" id="aplc:110979670"/>
    <dbReference type="OMA" id="VESQNTH"/>
    <dbReference type="OrthoDB" id="10117827at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091372.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="41001" checksum="D339153A85562C9A" modified="2022-01-19" version="1">MQDKYVAMRQQTHRAPHSCKANERLGEKESEEASARGGVAKEKRNPDPLPRIRVEECGLTVDMRKRRDGQSRPSKDRDQLDGKTSKTTSPFRAGANSEKNQAEGPTACLRERRFAEGKDGPNGQTVVSERRFSTEFVDSLRIGKADGHALTRGQALPGPIEPRPVPRMRYSKGAPLSRSIGDAVDTFQSRRAVSIGAVSSRERVVIRRLAAKRSETVSASQDLMSLSTDRGRRSSERLQQRTSLRDRRCHSMEDTRSRLGMVSRKYKRGGSTHWDDFDFHLTYVSPHDMARELRSRSGVDDFVGDILDKTRRSTPGERGGSSGTSDGSSVVHSVDCPMCHLYEPSRFGHVCPPNTPLKQLDRNDEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFV7</accession>
    <name>A0A8B7YFV7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110979733</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110979733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091472.1">
        <property type="nucleotide sequence ID" value="XM_022235780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFV7"/>
    <dbReference type="GeneID" id="110979733"/>
    <dbReference type="KEGG" id="aplc:110979733"/>
    <dbReference type="OMA" id="SMEQECK"/>
    <dbReference type="OrthoDB" id="6075577at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022091472.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25701" checksum="D14832B5E1337C8D" modified="2022-01-19" version="1">MGAWTSRSRTRDLSEISKLEEFIVKDTMVLFIDGNEKSIELCVGDMSKMGTRNKVDILMLSCLPGRYDTPKGTVVHSLQTNLGVNLADLAKDKEVDRRDTCKCWWSKNLGQIYLPFDRVLCYESGDHKPNTADLASTVFKCLKDISMEQECKIATSLLNTGRQNVGEVEMLEILVEAAILAMGDGLNLTQMMVFINGKYKAEGKCEPQTRNFKEICAKFDQLKSKHTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YG01</accession>
    <name>A0A8B7YG01_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110980119</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022092164.1">
        <property type="nucleotide sequence ID" value="XM_022236472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YG01"/>
    <dbReference type="GeneID" id="110980119"/>
    <dbReference type="KEGG" id="aplc:110980119"/>
    <dbReference type="CTD" id="4173"/>
    <dbReference type="OMA" id="AFFKCNV"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="505"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022092164.1"/>
        </source>
    </evidence>
    <sequence length="911" mass="101703" checksum="BC59F237177ED96C" modified="2022-01-19" version="1">MSSPSSSVTSSPRSRRSSKRNRADDDTDVDKTPNKRGRKGSQQSETPRRSTRDAAGMSSGTPGGPRTPSSRVAKQRNAVSPPASEVGRPLDSSPSGDLRPMPSSPASGGLQDISVFSSPGLSRAGTSDIGMSSPLNYGTPSSRMSGTPGRMAGTPLRPRNDITSNRKMRQVNLQSDPSGDGSEPTAAVTSEQPGGPQLVIWGTNVVVSEAKSKFTRFIQRFIDPDTEEAEGIDPNEPLYLQKLDEINTLELPFLNVNCQHLNQFDSDLYHQLVCYPQEVIPTFDMAVNEMFFERYPDTTLEHQIQVRTYNTEKTKNMRSLNPEDIDQLVTISGMVIRTSQLIPEMREAFFRCHVCAFTTTVEIDRGRIAEPSVCRNCQTKHSMALIHNRSQFSDKQMIKLQESPDDMPAGQTPHTVILYAHNDLVDSIQPGDRVSVTGIYRATPLRVNPRQRNVKAVYKTYIDVIQFCKDDASRLHEQAGDGDEQQIFTEERKQLLIDLSQKEDIYERLARALAPSIFENEDIKKGILCQLFGATQKDFSETGRANFRSHINILLCGDPGTSKSQLLQYVNNLVPRGQYTSGKGSSAVGLTAYVTKDPETKQLVLQTGALVLSDNGICCIDEFDKMNDSTRSVLHEVMEQQTLSIAKAGIICSLNARTSILAAANPVDSQWNPKKTIIDNIQLPHTLLSRFDLIFLILDPQDEIFDRRLANHLVSLYHQGGEVEDGEHMDLALLRDYLSYARTYVHPKLSEEASQLLIHAYVEMRKIGSARGMVSAYPRQLESLIRLAEAHARMRFSNVVETVDVDEAKRLHYEALKQSAFDPRDGTINIDILATGMSTSARKQRQEVKGALKKQIEGKGRVATLKYQTTFEELRQQSEMPVTKEMFDGALRELQDEDFLIWLGKTIRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YG47</accession>
    <name>A0A8B7YG47_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MIT domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091562.1">
        <property type="nucleotide sequence ID" value="XM_022235870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YG47"/>
    <dbReference type="GeneID" id="110979802"/>
    <dbReference type="KEGG" id="aplc:110979802"/>
    <dbReference type="OMA" id="FYKASNP"/>
    <dbReference type="OrthoDB" id="19553at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02683">
        <property type="entry name" value="MIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02685">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.30">
        <property type="entry name" value="MITD, C-terminal phospholipase D-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052817">
        <property type="entry name" value="MIT_domain_contain_protein1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032341">
        <property type="entry name" value="MITD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038113">
        <property type="entry name" value="MITD1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045331">
        <property type="entry name" value="MITD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21222:SF1">
        <property type="entry name" value="MIT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16565">
        <property type="entry name" value="MIT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="1">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091562.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="28035" checksum="1A4AAE59895F0F07" modified="2022-01-19" version="1">MASTSGFEASAANVLKRAVEMDGKSRFTEALVCYQEGLNLLMEVLKVTTDEAKKRALRTRLSDYMDRAEKIKQHVEKEKDAGKYHEQIHIAAGSTQNSYRRVFGRFLDEFVTEVYVEDPYIRSPSQTYNFLRLCELLVGRETKVKRITLLTGRDEGNAHQQEARFEEIKTSLAEHGVTLDIRYSSTLHDREIRLNNGWIIKIGRGLDYFKNTGKFSIGFCDMDLRKCHETTVDIFHSKHTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YG82</accession>
    <name>A0A8B7YG82_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NACHT, LRR and PYD domains-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091405.1">
        <property type="nucleotide sequence ID" value="XM_022235713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YG82"/>
    <dbReference type="GeneID" id="110979690"/>
    <dbReference type="KEGG" id="aplc:110979690"/>
    <dbReference type="OMA" id="RMLCLLW"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="48"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="229"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022091405.1"/>
        </source>
    </evidence>
    <sequence length="1116" mass="124839" checksum="D6728BADB7BCA447" modified="2022-01-19" version="1">MDEASANESGVASSEGRAPVKGNEEGPSSRPSVSGLQVAQTPEEQCVNETILHKMAEKLGRNWKALAIYLGITSSEVDAIVGDIPNDTVHQGFNMLVKWTQSQSLSVKDQMTKLCTALTDIKRVDIANMVQGIQTSALSGPDQLEICQDLLFTFYDQHKAFIPKFISSSMLPVLSIDDFYIPLQLLKSGQHVTRKDVRMKRTTRILNRPTTEPLHTWEEFYDEKGVGKKMILLSGGAGYGKSTILVKIVRTWKKGEGSTVGKFKLMFLLRLDKMATGCVLDAIYDQLLLRTDKLKKSDLKRVISDNEADIAFLLDGLDEIPSSALKSKEGEYPIGDLLGNKVLLKSCVLVTTRPHMVERVIKGFPDYARVETVGFTVKNRNKYIETHFPNDLTIARDLISWLDSNQSLQELSQCPIIARMLCLLWLNRPDASKPLPDKLTTVYKEFVEALIKRCHSASDTGENKSGVQQLMRTILEGLGEVSLQGLLEEDTVYFNPKDFAGRDVVLKNGRETGLLQKEKVASGLSDVEVVTFLHKSFQEYCAAYHLTSLLTKDGEQREGFRQNLQNIISVGVMKMQYVLRFCCGLSEEAAGLILSQMRRKGSDDVDQQSLARLLLFESGSTRLAFKLERPNWLSCWGQEQMAALHFYLESGIKPLKGTSFVIYCRSCVDVKMLGDIFRSCKSKLWTLIVECVLSDQGVDMLQTLEKVLRTADKVLLSRKLMCIKVKIFAESDYGAQNLLKCISHVPSQVWNICVSKRSPEDVYALLDALKDHALQSFSVDSVNMHGRVPALGLLVSSSLKSLGITDCELDDDDAKDLMGILPAGHGLTDLYLDDNVFSMDAVEALASHFQHLPELCDLSLDNVGNEDRVEQVLKQNIPQLEANATKASQWFPCSSYEDAEQLKQSFSTSGRVASSGWIVIYYIMSERGNEEMELFEKTLSTLDERLLGRLEFSLTVVEGSVYDVEQLTKFSCRLSSLVERFKLFMRERPAADVIRLLDSVTGECCLTNLEITGTNMQGNVIHLAPLIGPSLEKLKLAECGLNDDDVGYLKYILPAGQDGLEELDLSYNEFSLEAVRALTKHLRSFRYLTEVWLWSKCVDDAVVKQVIREFLPNLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGD7</accession>
    <name>A0A8B7YGD7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TOM1-like protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110980193</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TOM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092303.1">
        <property type="nucleotide sequence ID" value="XM_022236611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGD7"/>
    <dbReference type="GeneID" id="110980193"/>
    <dbReference type="KEGG" id="aplc:110980193"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03565">
        <property type="entry name" value="VHS_Tom1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000001">
        <property type="entry name" value="TOM1-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000003">
        <property type="entry name" value="TOM1-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014645">
        <property type="entry name" value="TOM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856:SF137">
        <property type="entry name" value="GH05942P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13856">
        <property type="entry name" value="VHS DOMAIN CONTAINING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036948">
        <property type="entry name" value="TOM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="5">
        <location>
            <begin position="29"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="6">
        <location>
            <begin position="290"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022092303.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="68249" checksum="D395656FD9777699" modified="2022-01-19" version="1">MHTSLSSCKMSFFGSNPFVTPVGQRIEKATSEGLASEDWGLNMEICDIINETEEGPKDAIKAIKKRLLGNKNWKEVMFALTVLETCVKNCGHRFHALVCKQDFVKELVKIIQPSMNPPTVIQEKILSLIQSWADAFRTKPDLQGVVKVYDELKQKGIEFPATNLDELSPIVTPQRATPEVDPASRRAAPTRQNSQPQMQPQMTTPYPPQQGAYSPQQGAYPPQPGTYSPQPGTYSPQQGAYPPQQGTYPQQQSPYPPQQSPLNTGPIPVQPSSPAQAPVPAPAPAGLTPEQLAKLRRDLEMVLGNVRVMSEMLTEMVPGQEDPSDLQLLQDLNKTCRAMQQRVVELISSINNEEVTGELLRVNDDLNNVFVRYDRFERYRQSQTSQQPAQQMGVPSVPQAQPVAQPNSVSSAPPPYPASSSPAPPPAAQNTATLIDLGTDEPTSAPNAFASPAPVAAAGDMSQQMAGLDISGGAAPAVSTDEFDMFAQSRQTSYTDSRKSGSTYQDIMNLDQSGVTMGNLVNARANPFSAAPVAEPAQEVEPELAEEGLPPNVDVDEMEKWLNATDLEKANDGLAAQNTNSQEEAGITSSEFDQFLEARAKAADTLPSQTSQTRQNKMEEAENTMFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHC2</accession>
    <name>A0A8B7YHC2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heterogeneous nuclear ribonucleoprotein U-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110979500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091036.1">
        <property type="nucleotide sequence ID" value="XM_022235344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHC2"/>
    <dbReference type="GeneID" id="110979500"/>
    <dbReference type="KEGG" id="aplc:110979500"/>
    <dbReference type="OMA" id="NYNERWE"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12884">
        <property type="entry name" value="SPRY_hnRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035778">
        <property type="entry name" value="SPRY_hnRNP_U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381:SF56">
        <property type="entry name" value="B30.2_SPRY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12381">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022091036.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="45786" checksum="43305B9F52A576A5" modified="2022-01-19" version="1">MAVDSACVLSTYISDLNVTITGGGLSAEPQTSEGFAYLWGGVKATYGVGKGKVCFEVKLEKHLNVRHLPPDEPNPHVVRIGWSADSASLQLGEEDFSYGYGGTAKFSTRGQFRDYGLTFGAGDVITACLDYSSGKPVLSYWKNGHYIGLAFTSTNILRGKALFPHLLLKNTAVSVNFGHRAQPYFPVPEGYTLFGSLPVGDRVREPLAPATKAECDILMMVGLPGAGKSAWVEKHCKEHPEKRYYILGTNIIMDKMKVMGLRRERNYNERWEKLFQKANDCLHRFFEIAPTRKRNYILDQTNVYQTARERKMRPFNGFSRKAVVVVPTDDEYRRRIEKRRMEENKSEPESDILKMKKNFVLPARGHLFQDVIFVDLGRTDAAQLVARYNSEGSQRSRWNDWLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHS6</accession>
    <name>A0A8B7YHS6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma</fullName>
            <ecNumber evidence="11">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110980002</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022091935.1">
        <property type="nucleotide sequence ID" value="XM_022236243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHS6"/>
    <dbReference type="GeneID" id="110980002"/>
    <dbReference type="KEGG" id="aplc:110980002"/>
    <dbReference type="OMA" id="CMLERGT"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16201">
        <property type="entry name" value="EFh_PI-PLCgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13362">
        <property type="entry name" value="PH_PLC_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08592">
        <property type="entry name" value="PI-PLCc_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09932">
        <property type="entry name" value="SH2_C-SH2_PLC_gamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10341">
        <property type="entry name" value="SH2_N-SH2_PLC_gamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11825">
        <property type="entry name" value="SH3_PLCgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000051">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000009">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000011">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056586">
        <property type="entry name" value="EF-hand_PLCG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016279">
        <property type="entry name" value="PLC-gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035023">
        <property type="entry name" value="PLC-gamma_C-SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035024">
        <property type="entry name" value="PLC-gamma_N-SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057061">
        <property type="entry name" value="PLCG_EF-hand_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF159">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23329">
        <property type="entry name" value="EF_HAND_1_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23583">
        <property type="entry name" value="EF_HAND_2_PLCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000952">
        <property type="entry name" value="PLC-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 11 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11 14" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9 11 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="2 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
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        <location>
            <begin position="537"/>
            <end position="642"/>
        </location>
    </feature>
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        <location>
            <begin position="653"/>
            <end position="742"/>
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            <begin position="773"/>
            <end position="833"/>
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    <feature type="domain" description="PH" evidence="17">
        <location>
            <begin position="848"/>
            <end position="905"/>
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    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="19">
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            <begin position="927"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="1042"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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            <dbReference type="RefSeq" id="XP_022091935.1"/>
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    <sequence length="1214" mass="140479" checksum="3BBF26967DFD7C1D" modified="2022-01-19" version="1">MATNSLYKKKLTPQEVASITKMLSMGTVMTRFYGKRKPEKRSFEICMDTRQILWRRQTGRTDGAVKIREIKEIRPGKNSRDFERWPDEAKKYDSSLCLVICYGAEFRLKSLSVVAGNADERHKWIVGLNWLVEEHKKSTYPSRVEWWLRREFFALGKSKTDTVSLRDMKSFMPYVNLKMNTKDLKEYFSEVDRWNKQEIGYDGFVQLYHNLIFQREVADRFKEYIDERNLVTVNGMIRFLAQEQKDTVANNPVAVKSLMESFLSGLGRPCQDSDPKFTVPEFLLYLFSPENEIWDKRYDEIVDDMSQPLCNYLIASSHNTYLTGDQIASESSCEAYVRCLRMGCRCLELDCWDGPEGMPIIYHGLTLTSKIKFMDVLKTIKEHAWVQSDLPIILSIENHCTLIQQRNMATSFQEVFGDALLTQPVDRDATTLPTVNQLRKKIILKHKKLTGASETFSVPTEEMSGLDVRNSLKNGILKIEDPMDNEWVPHFFMLTTEKLFYCEQTQNVGNQDDDDDTSSQLDIQATPNDELHFSEPWFHGKLNSNSDVPPRMLAEQLLTQYQKGDGTFLVRESETFKGDYSLSFWARGKVNHCRIRYKLDQSRPKYFLVEHTCFDSLYSLISHYRQCPLRSRGLELLLTDPVPQPLSHEGKDWFHKKLSRTQAEEMLKRVHQDGSFLVRKREQADDSYAISFRAEGKIKHCRINQEGRLFAIGNAHFESIVELVSYYEKFPLYRKMKLKYPVNQEIVDRLGGAADENSLYGNPELYMDPNQFVPKVTVKALYDYKAQRDDELSFCKHAIITNVDKQDLGWWKGDYGGKKNMWFPSNYVEETQPNDNGPDSMLMGNLQKGVIDIRRCVVETLPASRSTHPYVFRISPLNNRPSIDLAASSTEDLGDWIQTIEDASIKAEARRLEETRHERKMRIAKEFSDLIVYCRSVPFREDNIPGNYYEMSSFPETKVERYLTISKSKILLEYNKHQVSRTYPKGQRFDSSNYDPVPIWNIGTQMVSLNYQTPDRFMQVNEGFFALNNRCGYVLKPACMRDAAFDPYDQRTVSGVDPIHLNITILAARHLEKTGRSIASPFVEVEIIGLDRDNAQKYKTQTVADNGFNPIFSERCEFDVVNKELAFIRFVVQDEDVFGDPNFLGQRTLPLRAIRTGYRSLPLMNGYSEFLELASLLIHVESRVIGSTDNNSARDQPVCRAEARYDIGAHAIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIP4</accession>
    <name>A0A8B7YIP4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Down syndrome cell adhesion molecule homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110980586</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022093108.1">
        <property type="nucleotide sequence ID" value="XM_022237416.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980586"/>
    <dbReference type="KEGG" id="aplc:110980586"/>
    <dbReference type="OMA" id="GHTMELP"/>
    <dbReference type="OrthoDB" id="10001713at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd20958">
        <property type="entry name" value="IgI_5_Dscam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000333">
        <property type="entry name" value="Down syndrome cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000017">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000104">
        <property type="entry name" value="Down syndrome cell adhesion molecule b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000120">
        <property type="entry name" value="Down syndrome cell adhesion molecule like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000093">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056754">
        <property type="entry name" value="DSCAM/DSCAML_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF53">
        <property type="entry name" value="DS CELL ADHESION MOLECULE LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25059">
        <property type="entry name" value="FN3_DSCAM-DSCAML_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1630"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="55"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="258"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="346"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="438"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="535"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="627"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="720"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="816"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="919"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1021"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1122"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1223"/>
            <end position="1319"/>
        </location>
    </feature>
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        <location>
            <begin position="1319"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1410"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="1508"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1838"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1891"/>
            <end position="1915"/>
        </location>
    </feature>
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            <begin position="1929"/>
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    </feature>
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            <begin position="2160"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1955"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1967"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1994"/>
            <end position="2004"/>
        </location>
    </feature>
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        <location>
            <begin position="2028"/>
            <end position="2046"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="15">
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            <begin position="2085"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2095"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="2196"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="2210"/>
            <end position="2224"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2227"/>
            <end position="2238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022093108.1"/>
        </source>
    </evidence>
    <sequence length="2246" mass="247609" checksum="24049F3FBF88331E" modified="2022-01-19" version="1">MQLRSLDLALPSRTAALTTGMGVCRTYGRLLFAAALLLSLVCLPVTGNTNQLIGPQFVAVPPPRVDFAHNGGAQLVCSAYGEPTPAVQWVLAADDSPVTDVAGLRLVTENGTLSFPPFTPEGYVSEVHEATYRCIARNRVGAIRSPNIQVNAVIIQAYTVELHDNHVMRGNTAVFKCAIPAYVKDYVEVTSWSRSTNPLTSEGRFSILPTGELHIRDVRDEDGTGYQYRCSTKNRLTGEVKVSRAALLNVANPTNTVPEMINSRREYVGKVGDAVELPCVASGYPIPTYHWKKDSQPVILDDRLTLKGGNLLINRVRLEDDGVYECEATSDSGSVTASRHLTVREPLAVYFYPQRRSVDVGAFANFNCTVSGYPIERVTWYKNAQPLDGDDRVTIFDNGTLEVSDMTRGDRGMYQCVASNSWETKEATMQLSMGAAKPILLDHFTNETLQPGPNLQLSCTVAGNPTPEVTWYRDDAPIPPISRYANNDVINADGDVVSYLNITGLRTIDGGLYRCEATSEIGVASHEDHIFVIGPPFVRPLPNITAVADRDLTVHCRVVGYPIQSITWSKRGLTLPTNIRQTVHPDGTLVIRRVEQGRDEGEYVCTARNQQQLTHSQKFTLAVHIPPEIAPFSTPPLPQGQRTQLLCTIPRGDVPITISWLKDGEPIPPGIGITQSQTAFSSSLLILDASPVHDGNYTCVASNMVATVNYTTELVVLVPPRFVLQPEDTSVVLNHTVYIPCVPDGKPKPVVVWKKAAGPGASNFMDLPEDTRISVTENGSMMIEEVEEEDGGFYLCHISNDVGSDSKTAKLSVFLPARFDDHEENITLDAGQDVHIDCLATGHDPLEIQWRKDGVLYTRLELEGKFEIQNVAARNSLRSVLSVFGVGREDSAVYTCHAENAYGTDERTTRLWVLEPPEPPSNLSALAITSRSATLGWRPEFDGNSPLTGFTLEYKNGSDAWQGGLPTAHVPANVTRYLWTIAKLHPYNTYNVRIYAFNAIGISEASTAILFTTDEEVPSGPPLNIEMDSHTSQSITITWRQPRADLQNGVLLGYQIRYKDRDSPFQTISIPVETGYIETYTLNHLRKFGEYTIQLAGYNRKGMGPWSPERNIFTLEDVPSEPPRTVNAVPTGPTSVMVMWDSPASQDSLNGILQGYRIYYEPVREDEDETDARVYETLELNAHIYNLQKFTNYSVEVVAYTRVGEGVRSPIIFVRTQEDLPGAPADIKAYAASPTSIMVAWLQPLSINGILLHYYLYVKFMEGENEVTRELELDPDVHHYLVNDLQTNHEYDFWVRGKTVIGKGESSRVATEIPMTRVPARVMSFSKTITTTWKDDVTMDCLAVGEPTPVIEWKKNRSVLEQNDLVQVLSNGSLSIRNVQPSNAGNYSCRASNRWGAPDEITVALYVVAPPYAPILSVGARTANSIQINWKSGGNGGSPILGYQLNYKREHEQTWTPEDINSTLRSYRVTDVLCGTPYTFFMVARNKLGASKPSEELEVRTLGEIPIPPSTDKIVPYSNATSITLVLSSWGTGGCPIRSYSIQYQHFGDDNWVQVSSNIPPSTSRYTVEELHPESWYVFRVTAVNGAGPSVYSFRIATTAFGGGTAAPLDVRIDQSTDENQLLFYENPLLFGPVLGGITLLLIILFIGLFVFSARKHRKAVLKKAAIKEAETNRLENNNFPTNARRYIRPVEGALAAEQEPFLSGGVAPINNLSSITAATPWVFNSSSDFDGEALEGAVGGDPYLNYNPDDSSDVLFPSMSTFRSTGSDDVSIGDLGPHGGAVAVERLYDLPPDSEYMGTPGNRASMSSSHDYACLDDIRPHMVPVVPNRPQNVYCGTPAGTTRPTPPHTPGGTSIGRRVPSKRGSQASICTSASVSEELASAYENACQLERARRRNPPSVTSPGAVSHPDNYDYSTASDIEAGIRRFTASPPLPSVPERSDSYIPHRTVSYVKEGARPREYVRRVSTTSPHPSETSESEQDRSRFHAQVYRPSRYKANRRGRKGYMASRPVIRASRGPARRQRQFDSRSSTPSSSSPDFSGSRRQIGLRHDPSSPSEGYISLPYDSFSAAPSGVTDSDTEPRWKGYHHRRKPREKGSLSEPERGYAKKPPLPPAHRQSATPVPKVLHPNTRYHVPKYSVVSKDRTIYVGQKWGSREHPQWEEDITHVGSGGPKVGFEDLQAGHEVSSDKSSFPSCSPPPPPPPPPMRRHSPDGNDHCMEEIEIHVLSSTTSTDSPSNYRDEISIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKE7</accession>
    <name>A0A8B7YKE7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">RNA-binding motif protein, X chromosome-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110980952</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093733.1">
        <property type="nucleotide sequence ID" value="XM_022238041.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093734.1">
        <property type="nucleotide sequence ID" value="XM_022238042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKE7"/>
    <dbReference type="GeneID" id="110980952"/>
    <dbReference type="KEGG" id="aplc:110980952"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022093734.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="55666" checksum="8009649931612765" modified="2022-01-19" version="1">MPAAEHDIPTKIFLGNLSFDTDEKKLQDMFAKVGPIDQLLLMRDKESGTSRGFAFITYVNANDAKDAVSRYNESELDGKFIKVDMALKGIKQQTMAARGGTSGRGMDRGRGSFRGRGGPVGRGRGEGPPSFGPPGRGGGPPGRGGPSSRGGPPGRGGPVGRGGPPARGGLPSPRVTPYPARGGRPHGGPLPESQPARDDYPAQAAPRAGPPRSGKEPLLSAPPASAVSDYRARGYDRGYEREPEPRREPLLESRGAPYDFRPDYDHAPRPVYDAEEPVEPRRRAYPEDEYGAAPASARPSRVSYGEADPYARERYPPAREEPAPRRAYPEREGYAARERDPYAPPARDSYSTAAASRPSYDYSLPASRETPAAQREYAPATARTASRYEEERGYERAPPREAAYGREYEREAAPSRSSAYADQYPRSQARAPDREYAGSSSAAPRYDPYSYAEARSARPAEKSPYGARDSYGSPSSAGGRGAYPAERASRPLDHNGGGVPPATRAPPPSRGYERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKU8</accession>
    <name>A0A8B7YKU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18 19">Potassium channel subfamily K member 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">LOC110980553</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093050.1">
        <property type="nucleotide sequence ID" value="XM_022237358.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093051.1">
        <property type="nucleotide sequence ID" value="XM_022237359.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093052.1">
        <property type="nucleotide sequence ID" value="XM_022237360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKU8"/>
    <dbReference type="GeneID" id="110980553"/>
    <dbReference type="KEGG" id="aplc:110980553"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF330">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="82"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="181"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="396"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022093050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022093051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022093052.1"/>
        </source>
    </evidence>
    <sequence length="489" mass="54014" checksum="15A9BDED6AA538B7" modified="2022-01-19" version="1">MNWKSLFILVAAFILYLVIGALVFSALESTQEEETKIDLRAYKEAILSNFSCISEESLEQLVERIMNAVESGVNPLSNVSSKSNWDFSSSFFFSGTVVTTIGYGRRAPTTQGGRDFCILYAIFGIPFTGWLLSIVGQFYRESFWGLTERLDCMLCDYCSVTKRKLRRFIVWLVVASFTYGLLVLAPAGIFTILENWSYRIAHYYCFITLTTIGFGDFVATVDPKQQAPEVLEIVYDLAVVVWYIFGLSFIAIVISAIGTRERKTAKKLVSTLKNQQNSSPGETSPNKRASYSLQNAIRLTLQDGIVGPVSYHKGQSSNDPQTEVHVPSEAASNKQNNMLPSTSQETQSGVNPHYSANNNNGNAFNSQSGLEAGYEIQECDSVNIKLNVLNTALPQNDNMQKKKKPLGKKVSFDSSCNPNDGTSKIRRKATGKRKGSTRKSKLEVAGEEDESGENIQVVSSSTISMATGNPCCQCNCHTNYSDASQHVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLQ9</accession>
    <name>A0A8B7YLQ9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC110980862</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022093581.1">
        <property type="nucleotide sequence ID" value="XM_022237889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093582.1">
        <property type="nucleotide sequence ID" value="XM_022237890.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093583.1">
        <property type="nucleotide sequence ID" value="XM_022237891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLQ9"/>
    <dbReference type="GeneID" id="110980862"/>
    <dbReference type="KEGG" id="aplc:110980862"/>
    <dbReference type="OMA" id="KWEARSI"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="248"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022093581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022093583.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="55858" checksum="52CAA024B4EE97AA" modified="2022-01-19" version="1">MLTGMSCQEKSPSTQLVTVDTDYSADAVEFCPIAGQEGFLASGTYQLAESEGISPSSVDQVNPEDNGQVDKPRQRLGQIRFYHLNQDTEEASLAELQRIEMAAILDMKWCHNVISEQPLLGIVNASGELQLLSLNSKAGGFTLQPTACHRVSQDNNCLALSLDWNTGKYHSQTPSVIVSDSKGSLTLCRLCDDSSSVESMLRWPAHGFEAWIAAFDYWQPNVVYSGGDDCRFKGWDTRTPCSKPLFISKSHSMGVCSLHSNAHRENLLASGSYDELVLLWDTRQMRQPLTQTNVGGGVWRLKWHPHHGHLLLAACMHNGFHILDCANINGGNSQPIVASYMEHQSLAYGVDWCQHIQPHPPHKKLAESSLPDDIVSSCIETKQVHSSSDGTVPSLPEGDLAGALEGTSRSAGQKEGNCTSGTKQERGERTPNVSALTEQFLRANVSRNDLQASQGAPEAIAQGPACSCKVSGRTYKAFDRNADQLSVRDTIASCSFYDHSLHVWKVDWIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YM90</accession>
    <name>A0A8B7YM90_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynactin subunit 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093777.1">
        <property type="nucleotide sequence ID" value="XM_022238085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YM90"/>
    <dbReference type="GeneID" id="110980977"/>
    <dbReference type="KEGG" id="aplc:110980977"/>
    <dbReference type="OMA" id="AHYVREM"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF90">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="30"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093777.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="27590" checksum="F2E7FD0891F3FDAB" modified="2022-01-19" version="1">MVLFLNINIGQRVEVYYKGQIFAGTVKYKGGLSNVKGDWVGVDLDEPVGKHSGIFKGREYFTCTPKHGIFIHPSRIRFTPLKRNIFDTYRSVSPSSYVDETLFRSSSVPRATGPYDPVSVSDTFTRLASAGFENPSASWHAGKKCLSKSDSFSCSPTPSFNLSHSVGRAFTPKKPQRPKSAMELSSRGGNWGVDGGGRCTSPLRRFHSRADSPFISRPAVPKTHMPAEALRLQDMRGWACTPKPREWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMT4</accession>
    <name>A0A8B7YMT4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110981371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094578.1">
        <property type="nucleotide sequence ID" value="XM_022238886.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094579.1">
        <property type="nucleotide sequence ID" value="XM_022238887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMT4"/>
    <dbReference type="GeneID" id="110981371"/>
    <dbReference type="KEGG" id="aplc:110981371"/>
    <dbReference type="CTD" id="64224"/>
    <dbReference type="OMA" id="YMQLMAA"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01790">
        <property type="entry name" value="Ubl_HERP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000046">
        <property type="entry name" value="Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF27">
        <property type="entry name" value="HOMOCYSTEINE-INDUCED ENDOPLASMIC RETICULUM PROTEIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022094578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022094579.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="48860" checksum="54697E7777854213" modified="2022-01-19" version="1">MEQLTGMPVTLLIKAPNQKLGDQTVECFLDWSVQKLKNHLAKVYPSKPNEKNQRIIYSGKLLKDNLLLKDVLRLDDKSLQHHTVHLVCSPSPEELLQPYKPKSSPSPMADQVPSSSSVQGNSTGSSRTDGGTTTPATIQRRQSTPIEPSPPASAGGLRHRTVSTPSFSNFYPYSYGNYPMQYVQRANQQGYMAANQQQQAMWMQHMYAQQMAQYLQYSNQFQAGGAGLNANLPAAPAPVVVPQPQVPDQPGVINPPVVAPNVGAAAAAAAAGPDQNVRMNAGLGPAVDDDDEDNVNRDWLDWVYTFCRFGVMLSLVYFYSSPSRFLMVVGFMIFMYLYQKRWFRLHRAPIARERLENRNEQQEDREQDNSNQEQQQDENSEQDASGESQEEQETDSDSAETATAPLEPPRPGVLTVAWVFLSTFFTSLFPQDPNLAAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN82</accession>
    <name>A0A8B7YN82_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110981138</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094122.1">
        <property type="nucleotide sequence ID" value="XM_022238430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN82"/>
    <dbReference type="GeneID" id="110981138"/>
    <dbReference type="KEGG" id="aplc:110981138"/>
    <dbReference type="OMA" id="ECIKAND"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034265501" evidence="1">
        <location>
            <begin position="41"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="62"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094122.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21681" checksum="0F3267A94E0B0894" modified="2022-01-19" version="1">MPYAISSSTPTVLMNLFQNNMSLTNVLHLFLLALAGFASACEQGANSEKISAVTNDEVASKISQVNHAIQECIKANDAACVLKYYHDDVRFMPDGQATVIGKKNVEPFLGWVKDERKLKWRSDETGVMDPKANFVFERTREKIYLKEDTLVLDGKGVIIWKKTDDGYKIYVQIYNYNTQSQQTQKPSGDGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNS6</accession>
    <name>A0A8B7YNS6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Macrophage mannose receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110980585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093106.1">
        <property type="nucleotide sequence ID" value="XM_022237414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNS6"/>
    <dbReference type="GeneID" id="110980585"/>
    <dbReference type="KEGG" id="aplc:110980585"/>
    <dbReference type="OMA" id="GINSCCC"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048667">
        <property type="term" value="P:cell morphogenesis involved in neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000172">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033995074" evidence="8">
        <location>
            <begin position="31"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="44"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="10">
        <location>
            <begin position="214"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093106.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="46742" checksum="5579F7A35E2DED5D" modified="2022-01-19" version="1">MEDSSFARCLPFMAVFIGVFFMFILGTTQGNTLSDACDKDWLRYKDYCYFFSTTHMNFMEGRDFCKYRGADLASVHHDTERIFLDKNRPRGQRSWVGYNDLASEGHFVWTDGTTSYYNNWAPGLPYDFGGEDCTYSDPDFYGSKGNWNDVSCFQRYYPICKKRITASSCNDKPCQNGGVCESLSNGGYQCKCKTGYSGKDCEQDDFCKTEWHHFGDFCYLFRDEYKFFGDRHTWDGAQSKCESYGGNLVSIHSKEESDFIFEHMGYSEGRFWIGFTDKAKDGTFKWSDGTKTDYLNWRPGTPKDSENEDCAHVDPMYFGSQWSDVTCSKYYGYVCKDTIKMCEKHPCLNGASCVDMVQDYRCKCLPGFEGKNCETNTDECAQTTCPPGLIGVDGINSCCCVSDSPIDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNT3</accession>
    <name>A0A8B7YNT3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nanos homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110981238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the nanos family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094327.1">
        <property type="nucleotide sequence ID" value="XM_022238635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNT3"/>
    <dbReference type="GeneID" id="110981238"/>
    <dbReference type="KEGG" id="aplc:110981238"/>
    <dbReference type="OrthoDB" id="10010129at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.30">
        <property type="entry name" value="Nanos, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008705">
        <property type="entry name" value="Nanos/Xcar2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038129">
        <property type="entry name" value="Nanos_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024161">
        <property type="entry name" value="Znf_nanos-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12887">
        <property type="entry name" value="NANOS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05741">
        <property type="entry name" value="zf-nanos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51522">
        <property type="entry name" value="ZF_NANOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nanos-type" evidence="9">
        <location>
            <begin position="97"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022094327.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22505" checksum="F2B4041DD2DD08CF" modified="2022-01-19" version="1">MESCRITTLNEPEGFSPFRDYLGLAKLVVSHAQTRECEMVRGDEINDDFHCNGVDCGPCGLMPFTVPLVEGSPWGDSSGNLPSRTNRSRPCRRQITWCVFCRNNGEAECVYASHLLKDSQGKTTCPILRAYACPICGAKGDNSHTIKYCPVRHAEEIPPPAPLKTSRTSTGIRKTGACSSVNGYKPTAHQPTAVGERVAWDVRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQR2</accession>
    <name>A0A8B7YQR2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110981614 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095012.1">
        <property type="nucleotide sequence ID" value="XM_022239320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQR2"/>
    <dbReference type="GeneID" id="110981614"/>
    <dbReference type="KEGG" id="aplc:110981614"/>
    <dbReference type="OMA" id="HANSNYN"/>
    <dbReference type="OrthoDB" id="10180424at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034663233" evidence="1">
        <location>
            <begin position="26"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022095012.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24291" checksum="123E4E4821D06384" modified="2022-01-19" version="1">MAFSGAWALVLPLALFVAGFQPTSAAAVEWTVNGTNNAVCMIIKFDGLIRIPDNPNLTKYFQTAEVIDPQPNCTLDKRTVRIGYEGFADLFIELTFTKSTKTFALTQVSAAWYHRTDTGDTSEITRLTGLRSSDNLLPQSVSLGCYYFQEEVSISFDDFIVDMKDVAFQPFAGYANNSYGTEFTDKVCQVPSGVGHVGGDVMRNVVLAFISSTFLLWLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRB6</accession>
    <name>A0A8B7YRB6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Tyrosine-protein kinase BAZ1B</fullName>
            <ecNumber evidence="3">2.7.10.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Bromodomain adjacent to zinc finger domain protein 1B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">LOC110981611</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 34 35">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 24">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the WAL family. BAZ1B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022094995.1">
        <property type="nucleotide sequence ID" value="XM_022239303.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981611"/>
    <dbReference type="KEGG" id="aplc:110981611"/>
    <dbReference type="CTD" id="9031"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090535">
        <property type="term" value="C:WICH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140801">
        <property type="term" value="F:histone H2AXY142 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15628">
        <property type="entry name" value="PHD_BAZ1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000131">
        <property type="entry name" value="tyrosine-protein kinase BAZ1B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047174">
        <property type="entry name" value="BAZ1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047256">
        <property type="entry name" value="BAZ1B_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46802">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE BAZ1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46802:SF1">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE BAZ1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00571">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 22" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="13 25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17 24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0829">Tyrosine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WAC" evidence="31">
        <location>
            <begin position="27"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="30">
        <location>
            <begin position="771"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="28">
        <location>
            <begin position="1355"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="29">
        <location>
            <begin position="1358"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="28">
        <location>
            <begin position="1450"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="27">
        <location>
            <begin position="1557"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="282"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="954"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1274"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1413"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1669"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="1504"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="954"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="1003"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="1292"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="1420"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="1676"/>
            <end position="1688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00061696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="RefSeq" id="XP_022094995.1"/>
        </source>
    </evidence>
    <sequence length="1688" mass="193171" checksum="D2BA9C6EB600BB3A" modified="2022-01-19" version="1">MPLLGRKVYIPRTQDRAEKHPEGRFRVPFTNEVCKSKDHGSYSEYEKRMEFYRQPIWTCQCTGVSGLTYQEACRSEASAREQVEDEFPIRLERIVMELVHHSATPLDTLVDEVQAHLQNHFEVGETVELKVQLKGKIIRGKVLKVTQSSSNEWTALTIPDTMARAQMKEGNSPSSDKENHVDEGSRTPLKQGKKFSNKNFRYTIRLCDEDKIISSIPSHELTHTSPLPSWDLIKLFIRANAIQTGSAFNSPWIVSEDLFTKFNLVNKYDDLSLSPYKTTYETPKVHKRSAEESQSTTKSSKKRKLSDHFNTPKMKQSTLLDMSFKSKSAQVAGHRSESDDPNQMPSPEKVRMDHTYSSPIGKSLHKNSPKQSPKKVVASKKGSPEAKKALGKATLKKTQKEETSAKKKDNAAKAREKKSTQKSKPGREEEAKARKTRKTSIKKSSMEDEVIDVDMIQDGPYMGQKTPSKKKLTDHFKMLQSSTPSEDEFKVTPKKIPLSKQAKNKTAPTKSKTKALAQAKKENGKRAVTKVPRKVSSGTPKKVISPKKKTTVSPVKKTKPVRQETNTKSPVKSPKTGSPRKSSTKIATPKKTPQKRGRTSPLKTPKSKTSLKQMTLFDVAGKKSKTPDSQVRYKLSTPQSPRQPPIITKLIRAKKNKDTVLYSKLMTKAVKELNDKQIKNLKPEIKEEVTSKYENYKMKLKWKSMTPEERKELMLRKREEKKKQREEEKQKKMEEERKMRLEQAKRYEDQDLKLKPLPTPKLVSMPDGLPNTLFGDIAMVVEFLNCYCGLLMPNDPYPVTADCLTKALVGGREGFAYLSRVLVILLKTLLQDKIAEDYKELSMSLSQIPVNMHTASELLRLSLRLDDQESDDQSSSGGSDEFINDDEVPQELVELLETSEFFELEPLKKLQLLVFLCHRILASYAVQDFMDNKQKVAARLWRDKIQTLKEKNEKLKEEKQKLREQREAERLQREVEMKQKAEAAGATPDGEGSETNPDDKPKEKKSRKKKHAKQDKEETTLEENEENLDLASVVKRRRLLAAKTKAEREEQEKMEREKRIKGEEEYRKMRAQEIFEKKFEDGIQQAKLALRQTPIGTDRNHSRYWVFSSVTPGLFIEKGWVDPNITYNSRNRGGAWEGGDSGDCTEKTFPKVGQNLWFQYESTKELEAILEALDNQGVRESALCIEIRKHYQDIVRMINLSRRSGPELRESDGPRELLQSLREDLLDIESHIRQGNLGGVEDPQRWEEQVKTATKLKDLGALIVESQAGVNPKFLQGIMAQPKPKPKPSEEDSKEDNDEEETNNEVGFFSEDGSGIPEKVTKWVEAVESAPTLSRLHLLLSIFEACVRWEKSAENAKCKICRRKGDEDKLLLCDECNQPFHLFCLRPALSTVPKGDWKCPACAPSARRSVRRRSYKGMDDSDESEDSCEDGSTTDEDFEDEDSEGEIEHEDVCIVCSEDGELVLCAKCPLAYHKECHEPPMRNFPRGRWVCASCQNRARSAQLKQAEQKVKKEALTRKKRLQQAKRKKAQDAARAAARKPKIAFTCKIAEDIISKMLRYRDSGPFRTMPDPADAPDYKEVIANPVDLHMLKDRCSCEEYQEQQEFLEDVRLLFTNAKQYYENDGHVNLQAKKLEDFFINLLKWNLPQAAEVWQQCSSQSRRSNRSQIFCNDDRSDQSYGRRSLRQQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTI0</accession>
    <name>A0A8B7YTI0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Caspase-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096599.1">
        <property type="nucleotide sequence ID" value="XM_022240907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTI0"/>
    <dbReference type="GeneID" id="110982481"/>
    <dbReference type="KEGG" id="aplc:110982481"/>
    <dbReference type="OMA" id="TIQRMEY"/>
    <dbReference type="OrthoDB" id="6093024at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070513">
        <property type="term" value="F:death domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037939">
        <property type="entry name" value="CRADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15034:SF5">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN CRADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096599.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="17326" checksum="D87B901637C918EF" modified="2022-01-19" version="1">MDETDKMRLRKNRKVLVENITPKEILDHLIQEGIFTPEICDEISRDTRQDQVRKILNELEKKGSNAFGAFCDSLRETRHYGYLVDALENTNIDEPDMAPPKHEENSASGEGDGTSKTHTTPTIQRMEYNIIGDKNLTMIGSNVTVHNQKPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTZ2</accession>
    <name>A0A8B7YTZ2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cilia- and flagella-associated protein 263</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982210</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CFAP263 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096167.1">
        <property type="nucleotide sequence ID" value="XM_022240475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTZ2"/>
    <dbReference type="GeneID" id="110982210"/>
    <dbReference type="KEGG" id="aplc:110982210"/>
    <dbReference type="CTD" id="244608"/>
    <dbReference type="OMA" id="TCQQHRA"/>
    <dbReference type="OrthoDB" id="10259713at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051885">
        <property type="entry name" value="CC_CF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025254">
        <property type="entry name" value="CCDC113/CCDC96_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15654">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 113-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13870">
        <property type="entry name" value="CCDC113_CCDC96_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC113/CCDC96 coiled-coil" evidence="9">
        <location>
            <begin position="184"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="98"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="190"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022096167.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="43950" checksum="0AB51778F767293A" modified="2022-01-19" version="1">MADSESVTTSSQDAQDDPLHDHSDDELQQMLEELKAGNKVLQNETIMFEKYLKRVEPNLTAAATTAAVAPTPSQSTHDARVMRKRSKSKGSGMDKHLKLSAEQKCDIAQREIEELREEIDKLKEDAEKILDTYKAVMEEADVRLSEVKKSSYEYERDILKGSVNTRTGKVVAEKVVRYFEDKQRSRDALIEKLRLKNSTLKVQKKKLHLQLKQKEEMGEVLHEVDFQQLKIENSQYLEKIDERNQDLLRLKLMSGNTLQVLNSYKKKLHTLTLESDRLKNEITSRNELLTRIDVETETVEAERAKAEELNRRLRQQLGDFRVPDVVEYVQEKADLYELAKTVKSWERKVDIAEMALKTHRKTWNTMKMNSQQNWGLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTZ3</accession>
    <name>A0A8B7YTZ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 83-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094811.1">
        <property type="nucleotide sequence ID" value="XM_022239119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTZ3"/>
    <dbReference type="GeneID" id="110981508"/>
    <dbReference type="KEGG" id="aplc:110981508"/>
    <dbReference type="CTD" id="220047"/>
    <dbReference type="OMA" id="DMRIQIS"/>
    <dbReference type="OrthoDB" id="10005859at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026702">
        <property type="entry name" value="CCDC83"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21468:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21468">
        <property type="entry name" value="HSD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094811.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="49282" checksum="856DDCB6A9252E86" modified="2022-01-19" version="1">MGKKGKKKESGKKSGKKGGKKKSSEPQMTIQEAILAYQINIKEQALEEFMYEIKGLEEKNQKHKERNERLKEEQLYHISTLLKQAKERDKELEQVTVVNKEHVEEALKDKWKAAKEEDQKIEDLKGEIAQRAAELEEELVTVAKWQEYRNKGQHEHAKHIKLLEQELLDMQVSFDEMKAHLERTLNVAKDEIHKSTEERLMEQKHIASEKAMTTLDKWSTQEVKDNKWLKKEAELHRVEAERLVEEVEVLEKENLEIMSRLFDCRIQDLKISRNFYLTQFGEGEDIDDGGILEEDLSKMDLESPDKPLAIGGATQGPAKAPRPKSATQRAVEAKVFSLAVKEQWEEDLGGSWADVNQLDNYLDYEDENFDDYLNLGPVELKLLRVTGHKMTVHKPKKLTDEEEEAKLSAPDVWPVTPEMLKTVTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUR8</accession>
    <name>A0A8B7YUR8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: squamous cell carcinoma antigen recognized by T-cells 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096230.1">
        <property type="nucleotide sequence ID" value="XM_022240538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUR8"/>
    <dbReference type="GeneID" id="110982243"/>
    <dbReference type="KEGG" id="aplc:110982243"/>
    <dbReference type="CTD" id="9733"/>
    <dbReference type="OMA" id="LWARYIL"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12391">
        <property type="entry name" value="RRM1_SART3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000098">
        <property type="entry name" value="Squamous cell carcinoma antigen recognized by T-cells 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008669">
        <property type="entry name" value="LSM_interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034217">
        <property type="entry name" value="SART3_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF25">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16605">
        <property type="entry name" value="LSM_int_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05391">
        <property type="entry name" value="Lsm_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="677"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="772"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="842"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="615"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="905"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022096230.1"/>
        </source>
    </evidence>
    <sequence length="949" mass="107884" checksum="69B7E5F4AE4D860E" modified="2022-01-19" version="1">MANIIDEHVLQASQPDEMSEEAENEGDEGEEDMEEEDSGSSDDDDLEETAIKELESQVSSNPYEYNGHIELIKLLRRAGEWDRLCHAYQRMSDLFPLTAELWLGWIKDQSACTRLDGREEVYKLFERAVMDYVSPDVWLEYGQFSIGGIGTPEGIEKARSVFERAIAAVGLHVTRGSEVWEVYREFENALLRNWQTERVSAIFRRQLSVPLMDMEDTYKEYESWLSEPVSENVRKAYEKAFAQLKKREPHEQQLLKAEPPVFAVYQPYLEYERREGNPARIQCLYERALTDNCLQIELWKDYTKYLDSELKVKSVVLPVYARAVRNCPWSSELWIGYLVTMERYQEPHSTKPFEKALGAGFSSASEYLQLWQTHIDYLRRRIDWGSEHEEELSQLRATLEKAGEHLATYFGVDGDPVRSLQQYSARMEAKHCGNMEAARSQWNEIMALGHANEAQMWLEYVNLERSYGDAKHCRKILHRAVAAVSDYPECLFEALINFEREEGTFETWENALKRVETQMVRVSEMRSKQAAKDQQETVQESSRKPAGAKIKGNKGKQRGQDDRRQDRNVKAVKRKHSDEKPQKPVTFLAAGDSPKSQDGGEEVFKMPLPPPPPNKTASPVKSASSQPGPTPPKQAKTSIAPLKQAKEEEASGQSQPGVRWGPPPKQKPARDPSKDHLTIFVKNLSYETTEKQIRSLFVECGEITEVRMVENYRHQFRGYCYVEFQEESSVEKALKMDRQSVEGRPMYVDRSMDKSTTETKKTFQYAMKMEKNKLFVSGLPRSATAKQLQELFGQYGKIQNLRIVTYRSGVPKGLAYVDFEQESDAARAVVGADSTVMDGHTISVAISNPPARKPKKEDKEEAASEVAESPYPPKSLGAKGVVGPRGKGRTQLSLVPRALQRTPAPKTQQSPKTAGQREGVTSQVTEGKPQAQTTGKMSNADFAKMLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUU7</accession>
    <name>A0A8B7YUU7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CDK5 and ABL1 enzyme substrate 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097073.1">
        <property type="nucleotide sequence ID" value="XM_022241381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUU7"/>
    <dbReference type="GeneID" id="110982744"/>
    <dbReference type="KEGG" id="aplc:110982744"/>
    <dbReference type="OrthoDB" id="5353095at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20556">
        <property type="entry name" value="CYCLIN_CABLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012388">
        <property type="entry name" value="CABLES1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896">
        <property type="entry name" value="CDK5 AND ABL1 ENZYME SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896:SF0">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025798">
        <property type="entry name" value="Cables"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="462"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022097073.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="62768" checksum="ADE9002420974508" modified="2022-01-19" version="1">MMAEVGRRRYQKSAKRRSDAINFLANISLDGNFSQPEDSPVKAESRHESRGGKGTGKTATDKQEKQTSDSNLYVPKGRAGLRDVGLTETDASTSEVALIPGTEESLFLGEARGRTRSTTKTILGVSSGSVRVKSFSERHERGSPLIPSKFDPGSRPRAQTQIPSAVDQVIKGRPLHPGLAVDTTVVEGAVPHKPVPYYHNVHHHHHHRHHTTSQVLSSQTQSADTDVLPLVSALKERPACTGVVHVAQSLPLHSHKQSRVLLVSARKVPFSLYSVLPYSRHSQHGLLRNDSDIIATSRTRKSSGTRGMGSDTFSGLTGIELGDSGKEISYRHLLVPTKDQAVYRRQHSMDILSSPHSPALRKIQGHPLSVQWDRGDSEISLLEHAASILPYDPMELDDPGLHAGKHSKVLTFTSYMVSILDYTKPSELKKDINQKFKDKFPHIDLSLSKLRSIKREMKKIAIDAGTLELLTLAHAYVYYEKLVLNGKINKENRKLCAAACLTLAAKMSDTKGADLQNLIKEIEDTFRENRKDFLQLEFPILVALEFSLHLPEAVVLPHYRRIAQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUX4</accession>
    <name>A0A8B7YUX4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Defense protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110982283</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the insect defense protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096285.1">
        <property type="nucleotide sequence ID" value="XM_022240593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUX4"/>
    <dbReference type="GeneID" id="110982283"/>
    <dbReference type="KEGG" id="aplc:110982283"/>
    <dbReference type="OMA" id="HCTIANE"/>
    <dbReference type="OrthoDB" id="2419613at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08544">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051237">
        <property type="entry name" value="Ferric-chelate_Red/DefProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828:SF9">
        <property type="entry name" value="CELL WALL INTEGRITY AND STRESS RESPONSE COMPONENT 4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45828">
        <property type="entry name" value="CYTOCHROME B561/FERRIC REDUCTASE TRANSMEMBRANE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034070455" evidence="9">
        <location>
            <begin position="25"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="10">
        <location>
            <begin position="15"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022096285.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="20614" checksum="10574324B62E2FBB" modified="2022-01-19" version="1">MASRGGKCLLILTVIAAVLSGVDSRPDGAPVAACTSLTPSHGVSLANGPSPYSLQLSQSTYTPGGMVSVTVVASQQYRGIILQARRTDGLSTAPQGSWLNLQDAQLLDYKRIRCSSTHDTITHTNRNDKSVSQTFTWLTPITDVGSVRFVMSVVQTYNTYWVNVESNVITYFAGEPLNCPIVFLRPIFSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVB4</accession>
    <name>A0A8B7YVB4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cryptic protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110982843</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097254.1">
        <property type="nucleotide sequence ID" value="XM_022241562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVB4"/>
    <dbReference type="GeneID" id="110982843"/>
    <dbReference type="KEGG" id="aplc:110982843"/>
    <dbReference type="OrthoDB" id="9893603at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019011">
        <property type="entry name" value="Cryptic/Cripto_CFC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09443">
        <property type="entry name" value="CFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034049458" evidence="7">
        <location>
            <begin position="24"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022097254.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25090" checksum="0B256D191C7ACA21" modified="2022-01-19" version="1">MQLTTDWGICVYLVVIFLAFATASEHQKGQFRESEVSLESFAHSPAVLTSDRVSSSGRPSGAGRSKPRRPNDTLGKGSGATKPRRQPVRDISEPTAYRHDSSHCKNGGTGFLRSFCFCTEEYKGRYCEDRVNSSCDTVNHGDWVYRNCSVCQCVDGVLECRRHELEGCRKEPDTSKYHSHQDGVALEMQPHSNGCILQGSLLTPLMALLVYFHRILWLQNTSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z059</accession>
    <name>A0A8B7Z059_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox protein Dlx2b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110983414</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Msh homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098347.1">
        <property type="nucleotide sequence ID" value="XM_022242655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z059"/>
    <dbReference type="GeneID" id="110983414"/>
    <dbReference type="KEGG" id="aplc:110983414"/>
    <dbReference type="OMA" id="SFPWMQG"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000729">
        <property type="entry name" value="Msx-type homeobox protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050674">
        <property type="entry name" value="Msh_Homeobox_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338:SF0">
        <property type="entry name" value="MUSCLE SEGMENTATION HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="210"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="212"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022098347.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38141" checksum="C1A7CD6192FB20C6" modified="2022-01-19" version="1">MSSSNKTLTVSINSAFSRPEYNASPTAGSTPTSPEKVPADPGRENLSFRVESLVGVKHEDPAPYAATEVDRGGAGAVRDHIDSSCVASSPTPSKPATSPCCASSPSFTYTVEGILASKPPHVSHNTNNPLKHHHQQQQHPHHHHNHHHPRPGDLSPTSKTYTWGSSSFPWMQGAQLSPNSLSVTNDGRPYGATPPGGPGPKVQCTLRKHKTNRKPRTPFTTSQLLSLERKFRQKQYLSIAERAEFSASLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPVLPPGFGFPFPPTYYSLGHIHRHAAMPGLIQPLQFAPYSYFPGSASAATHHGPSSSLMCPYSASGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z124</accession>
    <name>A0A8B7Z124_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022098667.1">
        <property type="nucleotide sequence ID" value="XM_022242975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z124"/>
    <dbReference type="GeneID" id="110983608"/>
    <dbReference type="KEGG" id="aplc:110983608"/>
    <dbReference type="OMA" id="NDPKHAG"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF79">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098667.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="39884" checksum="2BBEAD332C101050" modified="2022-01-19" version="1">MKSEETSESHVKVMGVELAPIRIPFHRRLETLAVLQWELTFLLSLIIVIVTSIYLLFTKYYPLVILAYLWAYYDRKTPRRGGRRCEWIRHWRVWVHMRNFFPVHLIKTADLDPGKNHLLGFHPHGIMSMGAFVNFCTEANEFAKKFPGIKPFLLTLSGWFRFPLARDYIMMAGVCDVSRESLDWLLGQSGPGNAVVIVVGGVKEVLEAQPHRHVIYLSKRKGFVRKALKHGASLVPVYSFGETNVYEQIPNPEGSFLRKLQALLTKVVGIPPSLFHGRGIFNYNLGFLPYRQPIFTVVGKPIPLDKNPNPTQEEIDKVHAEYIASLVALFDEHKTKYGIEEEETLKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z487</accession>
    <name>A0A8B7Z487_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Component 3 of promoter of RISC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110984183</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099777.1">
        <property type="nucleotide sequence ID" value="XM_022244085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z487"/>
    <dbReference type="GeneID" id="110984183"/>
    <dbReference type="KEGG" id="aplc:110984183"/>
    <dbReference type="OMA" id="DAFHFTI"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.190:FF:000001">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022099777.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27538" checksum="0426A802FFEE3250" modified="2022-01-19" version="1">MAESPPVNSIFSEFNEYLTNDQDVREEIRVAVRAMEQTAREVMTTLEGIHQAAGLKEAPVLCQKARKLLETTQSQFAELQKKVPADQYYRFHDHWRFVSQRLSFLVALIVYLEAERLVTREEVAHLMGVSVRREDGFHLDLEDFLQGLLQLASELSRLAINSVTAGEYDRPVRISNFIQELNAGFRLLNLKNDSLRKRFDGLKYDIKKVEEVVYDISIRGLKPAPPGGGEEEEPPTSSTGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4D3</accession>
    <name>A0A8B7Z4D3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110983333 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098211.1">
        <property type="nucleotide sequence ID" value="XM_022242519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4D3"/>
    <dbReference type="GeneID" id="110983333"/>
    <dbReference type="KEGG" id="aplc:110983333"/>
    <dbReference type="OrthoDB" id="10066064at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022098211.1"/>
        </source>
    </evidence>
    <sequence length="852" mass="98569" checksum="2097BFB2B1EA7708" modified="2022-01-19" version="1">MLKAMAQIKKDGIFQENMKRIKSNCSKKPGEPSHPLIRERQQGSADTVMCGECRGFYSQTRIWQHKQICHSTAIVKVCSVPAKSLKNTSNSEDQKFQVTVLDRFRSDAIGEVCREDTMIKEVGKKLWAKSIRREKSIIMNDMRRLGHLVVKMRELAEKETLCGEDVFKRQNYHLLEQTLDTLTEKPDDGVKAGLKISLGYLLKKGAKVMKAVYILKDDMKAAEEIDRFLSVLYLNWEYLFSRSSYIIESKRQAVLRKPQQMPFEEDITTLREFTINSLQEIVRGQHPSNCKIFRKLRALIVSRLTVFNARRGGEPCRLKITEWEDAADQRWVDPNLVEAIDDPMEKYLLSSFKLAYQRGKGSRKLVPVLIPPDTVQPIKQLMKMRHAVGVSDDNKYVFPYTQRSLEHVNGWAELKKVTKMIPNLKDPEKVTATRCRHRASTLYALLDIPERDREIFYRHMGHSSEINAHIYQCPLAVKEITKVGRYLLDIDGAPHTSTCAGTQEVTPWKRRKERHPTSFPQRSKGVIPQKCSRHAKEHLTSSPERLKEVTPRKRSHKHPLASSPESSKELTPQKRRRKEHPLASFPESSKELTTRKRCRKEHPLASSPGSSKELTPRKRPCKEHPPTTSPEPSKELARRKRRCKEHPPTSSPEHFKELTPRKRRCKEHPPTSSPERSKEETPQKCCRRKGHYLTSSPGSSEEMTPRKARLLKLIRELKAQCQTSSPSKSREVTPHKHCPKVDQHRKGSHLHFSHDQSEKARTYFQWNQKDFAYVQQEFKSYIMDTTFSGAKGPLPGSKQIAHFLKKFPHVLSDFRGTWKEKKLLVKTKVFNERSKARRMAAEKRDAERIAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4U6</accession>
    <name>A0A8B7Z4U6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">F-box/WD repeat-containing protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110983423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098366.1">
        <property type="nucleotide sequence ID" value="XM_022242674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4U6"/>
    <dbReference type="GeneID" id="110983423"/>
    <dbReference type="KEGG" id="aplc:110983423"/>
    <dbReference type="OMA" id="GIAHVWS"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000004">
        <property type="entry name" value="F-box/WD repeat-containing protein 11 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021977">
        <property type="entry name" value="Beta-TrCP_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12125">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM01028">
        <property type="entry name" value="Beta-TrCP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="203"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="283"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="326"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="366"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="406"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="455"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022098366.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="58715" checksum="DA2F52ED4476C707" modified="2022-01-19" version="1">MEISTMNEDSVSDLPDGMTIPVRSVSRNKEPSPNYEGEKATCLKYFDLWKENEQLEFVEHLIAHMCHYQHGQLNSYLKPMLQRDFISALPKKGLDQIADKILSYLDAKSLCAAELVCKEWKRVISDGMLWKKLIEHKVRTDELWRGLADRRGWGQYLFKPKPGETPQSDIYFRKLYPRIIQDIENIENNWRCGQHELFKIHCHSENSKGVYCLQYDDQKIVSGLRDNTIKIWDRQTLQCVQVLTGHTGSVLCLQYDDKVIITGSSDSTVRVWDVNTGQMLNTLIHHCEAVLHLRFSNGLMVTCSKDRSIAVWDMRSATEINLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTCEFVRTLNGHRRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRATSGTLCLRTLVEHTGRVFRLQFDEFQIVSSSHDDTILIWDFLNVPPTESLSSTGKSPSRSYTYVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5F1</accession>
    <name>A0A8B7Z5F1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Guanine nucleotide-binding protein subunit beta-5a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110984727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100869.1">
        <property type="nucleotide sequence ID" value="XM_022245177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5F1"/>
    <dbReference type="GeneID" id="110984727"/>
    <dbReference type="KEGG" id="aplc:110984727"/>
    <dbReference type="OMA" id="LDNKCTI"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022100869.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39136" checksum="96C9A586AF252B10" modified="2022-01-19" version="1">MAVTDGPAVKEEEINALTREAESLKIKLEEERRKLNDVDLMVVAEKLDTLPQLNLKPRRILKGHQGKVLCLDWARDHRHMVTSSQDGKIIVWDAFTTNKEHGITMPTTWVMACSYAPSGTIVACGGLDNKCSVYQLSQEEDLSTKKRAVAMHTSYVSCCTFMNSDQQILTGSGDSTCALWDVESGQLLQSFHGHNADVMGLDISPSEACNTFVSGGCDKQALVWDMRTGQCVQSFDGHESDINAVRFFPSGDAFASASDDAGCRLYDLRADREINCYAKECIIFGATCLDFSLSGRLLFVGYNDYSVNIWDTLKGLRLTMLYGHENRISCLRTSPDGTALCTGSWDYTLRIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z607</accession>
    <name>A0A8B7Z607_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101064.1">
        <property type="nucleotide sequence ID" value="XM_022245372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z607"/>
    <dbReference type="GeneID" id="110984831"/>
    <dbReference type="KEGG" id="aplc:110984831"/>
    <dbReference type="CTD" id="138429"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF46">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101064.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="67178" checksum="B08DB36B5133BA82" modified="2022-01-19" version="1">MTEGLNVSSSHSPPRGQGSETVQEEASFASLVRKAQKHWSHRGIIEIDKQHRLYKISRCIQMGIRGCISPHPSVEVENITHQEEDYLEVITQIHFEQDVNKQFEFRCYAPKVFASLRALVGVTEAEYLESLAPSGPPLPCLEFITSSKSGMTFFLCHNKAFIMKTEKSQDIAFLRSQFLHRLSRHFHDFPHSLLVKIVGCYFIKMSGSKGLFFTVMQSVFHPDERISERFDLKGCSASRYVQPLEEGSKEVIVLKDNNFDGRKINLGVQAPWFRRQVDIDTKFLEEQGIMDYSLLLGIQKLHADEKKTADKLADVVSRARRSIRAVSDSPSRVCPNCGGRFPTWNRRSNIKTQRPAAPPAEISSPHETYQNGDNTERMVREILEINLSSDSQQYTSHSGKCAADGEDWRENFYSRSQLSDNIYEQAHQDKEEVETGADKTQRNALPGMIEDDGSQPKPISSAKEEGTDKSKPTGKTNQTHSGNMRAAMLSPQQQNLSTTYCQCTGRFQIDKCTERNQRLLPDTINPLHIIDGVDDRYYVGIIDVLTQYGIRKKMEYLYKCLRYPTETFSTVKPEHYAQRFRELCCAKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6D0</accession>
    <name>A0A8B7Z6D0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Uncharacterized protein LOC110983719 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110983719</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PDGF/VEGF growth factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098895.1">
        <property type="nucleotide sequence ID" value="XM_022243203.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098896.1">
        <property type="nucleotide sequence ID" value="XM_022243204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6D0"/>
    <dbReference type="GeneID" id="110983719"/>
    <dbReference type="KEGG" id="aplc:110983719"/>
    <dbReference type="OrthoDB" id="8878063at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070851">
        <property type="term" value="F:growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11633:SF1">
        <property type="entry name" value="LD28763P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11633">
        <property type="entry name" value="PLATELET-DERIVED GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00141">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0497">Mitogen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Platelet-derived growth factor (PDGF) family profile" evidence="7">
        <location>
            <begin position="172"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022098895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022098896.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="39675" checksum="72F524F6075732A6" modified="2022-01-19" version="1">MDRAVTYIANCVGYLLRVFVVWVAVVTLYIQINALPTQIPPAVMYGMTQVRTIDDLLQMLDQPVKPVIPGQGKNSAWDLEVTQGQGVIADDDDEDRDEHDGDDSDEDSGSERQKPVPAVLTGYQSHPKTMLTPLQFSLADSSRRPVQEISRVDSPQSSLGLQISDVEPLPSCIPREAVIQVLPETSKPHVMFWPGCVTVKRCGGCCNSDLHECQPTRSETVQVKVVQMEYTPRARRYFQFDGIVIRNITNHTDCSCQCKIKPQDCNPVTQVHNNCQCQCKKLVSCPARKLWDPVRCQCVCITSQQDRRCLKRQEWDDNSCSCTCRKDLEASCRPPHWFNRRRCKCQRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6J2</accession>
    <name>A0A8B7Z6J2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">FYVE, RhoGEF and PH domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110984566</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022100577.1">
        <property type="nucleotide sequence ID" value="XM_022244885.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110984566"/>
    <dbReference type="KEGG" id="aplc:110984566"/>
    <dbReference type="OMA" id="VYHEGME"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15741">
        <property type="entry name" value="FYVE_FGD1_2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF241">
        <property type="entry name" value="DH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="799"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1015"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="12">
        <location>
            <begin position="1154"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1234"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="637"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="649"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022100577.1"/>
        </source>
    </evidence>
    <sequence length="1336" mass="149383" checksum="BAED31DADC22B38A" modified="2022-01-19" version="1">MLEIVGYQGHSSLQATMSESAWLSQHLCKVLPTEEASTESDNKEAVLPSLHRPNEKASRERRVPKHLPDPPFKETSFLDTVAEDESSQLTPHPVILKQAHQKGTKPLPSAPSHEIGKSGIGGAANQSPQVHRQERNESASSIEKVSKPLPKVPVKDTPLVTTHLRAEERVTAVSQPTTCLIPNVSAEKVEVIPSAPEREGHAPKSSYQKREGSCSQVSVSAKRQHPHSKVLKTLPEVLHACEGSVADPESEHAEKPPWSENDQKILGHSCLIPKLEEGLEAKSANSDTPVKPLPDIPPSSVNFAAVGLKKAIKPSVVPRQARRPAVTLVEGHLFKPLSRVLEEGAREESPALQASPKPLPRVPKQQNLEMASQKKSLGSTDASSKASDESQDIVNEVPSVSSASGSSEPLGLDFPDETKEQTVKEQPTTSATSKTVKAATVKDTERFLSVCEDTSFEDQLMTSESDLWSDTEGASTLEKTVIPLRQNKLLQLEDQDKAASNRGQVRRTSSTDELPVVSVSFTNTRGLFQKAQLMNSCDSLDSTAKPPVAQKPLISKKPAVNTGQDGTTNKPNVPPKVTLGSPPRTIPKPLKLPPKASEQPNRDNIYDEVYHEETIESEPSSYSHDKASSKKLEKILGPDFATSDPARPSIERDIKPVKGKQPMDPRSRKISAPARPTTDDGPYAVIPLPDADKTATKKTKNSAEQKAREISDGNGNKVVLRNSGGMSSGDSGIVGLNTDMLVKRGISRKERRMSRRILRQTIRSMDSDFMEDSDDEPIGVDSDFDSDTSLEEPAVFMDESHKTAFEVLTTERTYVDTLYLINEIFLKGIEKENQKQHWFPPTVVNEIFSNISSIYRLHSAVLLPDLDERLKDWERNPCLGEVLKKNAPFLKLYSDYVSNFDNAMKQLNQWMSKVPKFAATVSQLQNHELCGNLALQHHMLTPVQRIPRYELLLKDYIKKLPDGSKDKADADKALTIISGAAQHSNDMMKSMDQFEKLLKINQKIDGENIIDPTRHLLKEGKITKIAAKNKEPQDRYIFLFNDILLCCEKKRLLTSANYKVKLKMEVDGMKVSVLDSNSCRFIIESKTKSIEFQTNSEEEREDWMRVLLSAIQEMYWKKETFRTNDAVGDRQNGDEYGVKAKFVPGESCPRWIKDDETSMCMRCGTDFKLTKRRHHCRACGAVVCHKCSNFEAPLEYDDNKMNKVCIKCYYVIKGDEEEIKKLARRSLIPEIDEDNSFSSFLYLHYKGAWTKFWVVVTEQDMFVLKAPKDVRPVFTLPIKLYNIRNINDTDAERDHVFKLSDSRTVHTLSAESKELKRRWMTVLSEGVEKVIKQATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z770</accession>
    <name>A0A8B7Z770_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110985071</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101493.1">
        <property type="nucleotide sequence ID" value="XM_022245801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z770"/>
    <dbReference type="GeneID" id="110985071"/>
    <dbReference type="KEGG" id="aplc:110985071"/>
    <dbReference type="OMA" id="EVCVCCL"/>
    <dbReference type="OrthoDB" id="347244at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031390">
        <property type="entry name" value="OFCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33862">
        <property type="entry name" value="OROFACIAL CLEFT 1 CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33862:SF3">
        <property type="entry name" value="OROFACIAL CLEFT 1 CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="866"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="957"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022101493.1"/>
        </source>
    </evidence>
    <sequence length="1196" mass="135547" checksum="16E13D04D760D836" modified="2022-01-19" version="1">MEEDPAPRKKGKKGKAKGGKKKRREVTEKELSPGDQAVTDIPIPETKPKSPSPEPIGVSPEKPLQPTPEDGPSIEPALEAKAETVITIEDQPGVEATSTEQDVPLEDGDVERVPSPAKDDDMGVRTPSPPQLPEQEDEEPIFKPAPRTLDLGSRDFDNIDPREMGIDYLSDEEYQYEPPERSDLPDLYKLMNTLDGGESDLEAEAPPPSFFQRPEHEPNYKKISVLRQEMEEEEIDPYISQFDDTIRDDVLMIGNISLEEVQEEERRLRDEHIAFQQQEAILARRHQEDILLREEKAKGHVTKIMKEKRKALSRREQLNLQKERLLQDQLHKTFRKAENQLLRSLQIRKGEVKTMYGDLMMADGQYGGSKGRRWKVDWNRAPQPIQIKLKCLRGVKDKLPAGRYVLMVSLYDRIGGHVLRWSNLRGQEWGGATLPMNHEGRFHNVEIKIDQSVFTVCPSKPSIRPGMILQFELFLIRGSLLPVDKVVAWGVFPICDGQFNIIQGKYVTPMLRGEADPRIDRHETVEKLMASDIDHWLSNLYFEVVKLPRYIAGHKEYEVELQFSSNLLSYPDRTRTAEEAIDGDEPIMGSTAEVVSNSGDLSNSIGKGSQASLQAGSSDKTGDSADKAGSEQMNETVPRPSSRASLNNDQDIKQKISALEDKLSDLRYRGTTQPPPTVIGSRKLFSKDAKMHLDSDEENSEDEEYLQKLDGFEPVKGEAGLFYKHHMNPPATDYMRRLYTMLPKTGLLSPQRRKKKLTYLEELDTHTFAVQRPFSTKGHLARAGHEKVQYVSRQLFAELGLSQWRSREFWTLIVLLCLLFFVRVYMHYLGQWGYLSILGIPISKFEFLPYSVNLNYQSSLLHTRELVAVVILGPLTNIGILVLMVVAAWLCQKAAGSFPTLLCKLVIVFGLHAILDPILIAIVDAPLGRYNYEAGDEPIADAAKLYYHFQQTHGTGLMGILLTVPIYVFLMFLAIVIFYMYFLRLHNNGRMLDIFHRLHAKQEEFFLPYDLEISNQELAYICKKAEQWRGEEGERRKVAVYDYIWEEEDVDEERLDGEKQGKSKKEITTHVSIHTLHLDGLRELHRHFLRLPDGAIVEVFGEMGVVGLDKDLRTALQKGPSGQTNVGWDRMGSTDTLRTRQRPKTTGGFGSRDFLDIPPSPGAGPGQFASRESLQSRGSGGSLLSVGRDLGQESRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7H0</accession>
    <name>A0A8B7Z7H0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Centrosomal protein of 104 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110985123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for ciliogenesis and for structural integrity at the ciliary tip.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with CCP110 and CEP97. Interacts with ARMC9, TOGARAM1, CCDC66 and CSPP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101598.1">
        <property type="nucleotide sequence ID" value="XM_022245906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7H0"/>
    <dbReference type="GeneID" id="110985123"/>
    <dbReference type="KEGG" id="aplc:110985123"/>
    <dbReference type="CTD" id="9731"/>
    <dbReference type="OMA" id="VQGNDYN"/>
    <dbReference type="OrthoDB" id="66599at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000200">
        <property type="entry name" value="Centrosomal protein of 104 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052607">
        <property type="entry name" value="CEP104-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048739">
        <property type="entry name" value="CEP104_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048738">
        <property type="entry name" value="CEP104_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 104 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13371">
        <property type="entry name" value="GLYCINE-, GLUTAMATE-, THIENYLCYCLOHEXYLPIPERIDINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21038">
        <property type="entry name" value="CEP104_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21039">
        <property type="entry name" value="CEP104_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="13">
        <location>
            <begin position="422"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="316"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="671"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="715"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="892"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="892"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022101598.1"/>
        </source>
    </evidence>
    <sequence length="935" mass="105845" checksum="4A17CA0E9A890FDA" modified="2022-01-19" version="1">MPHKINFYVIHASGSDTGVSLHDLEVHSPLARGWRSPRFCLYPQEIVIQLADKTRIRKLQLLVHQYLIPTKIEFYIGSLPPDHVTTLHGTRYKRLGYVAMSDNSKTGYKARELKSVHVDAVGQYVRLVIHKNHVNKYNVYNQVSLIAINVIGDEITSEEDLQLLEKDNMLKVNQVIKEFMPEGYFSEESNHANKETDAAVFGAINRKDYISPMDDLAFDMYQDPEVAQVIRKLDVRKNEAVLQEQYDLAKKLKQAIADLQKVGEKLGRYEVEKRRAIETEDYDLAKIKKIQMEEYRLQIYQQLEVNDLLKLSKNLFWPPKNTGEKNNAVVPPENESPRNRLAHVRTSSPSTTGETAANISIPTTVDDRPLPTLKHSPRNDGTEPSHRQSDQDDAAERGEAVNDSVVAGGVQSEHVEPMSENTLRQAAAAIEIFGQELVSKLFSKNWTFREEALGEVKQKLENEVETIDKDELRNMLRASVFLSSKGLKDKVFAVFMSALSLVRSLYEDWIPKHKLNKADTSHSLEVVVPELMTRIGDTNARLKAADIDFIRELASYKEVRPLHSVPHHFVAPFKGTTQAKIAVTRVEIVEKLLKDLGIEKNSGLTVDSVMAFAKRALEHTAGEVREAAVHLIIELYHLKAAAVRSHLPPEDDPKTMKNPLYCKIFDGMDRADGKPTKAERKAKAQSEKALQRKQKQAEIEELQQQLSDLRAAAIAQGKNSEDTDGPSEGKKTKAANKDQLPKKMPRAPSIAEQSDFGDDIDKQCIFCGEEDKSFKDEGLDMHYWKYCPVLKRCHSCKQVVEISAFNNHLLTECEGRAKYAKCPRCTETHEKTEVERYVKDKICQPPKLGMSKCPLCHVSVTAADDKDGNWRKHLMGTGKDACLKNPRRELAIKRVREKSQAADKHKQTPRKQAESTAKSRIPTKDKKAKSKAHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8Q2</accession>
    <name>A0A8B7Z8Q2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985371</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102039.1">
        <property type="nucleotide sequence ID" value="XM_022246347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8Q2"/>
    <dbReference type="GeneID" id="110985371"/>
    <dbReference type="KEGG" id="aplc:110985371"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102039.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="41254" checksum="0278B4638228F57B" modified="2022-01-19" version="1">MITVLRIAEELMTVDYRKWFSSGWLPPSDRLLSLGPVRTDPPPLLPPLCDEPRKELAPDQSGLSNVPNLVERLQPMLEDFLENSAVPLKDQGDATTVAPVPGSDSGNLSDEQEAKPPWTSLAERPTNDAKGESRSTPHDQPVFQGQNASGKLSLINHLEDGVQPNPATEVGENFQRGNDTQSENQEACDADDKELKEASQHRIVHLPKKAESSEQESTVRNAFEVKMPLPSHFSEKTGGHVAATTPKPADNLESKLSISSPRRTPSSSADSSTSSALEEGREVSADPGGTQGDFQGNTETLRETVPSVLLSSSSENNEDYRVDDEDLKDEKNSSSSTHRRNQLSSGEESSKQESTLREFRTPAEAKMAAPSQLRYCVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9G9</accession>
    <name>A0A8B7Z9G9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette sub-family C member 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110985539</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102313.1">
        <property type="nucleotide sequence ID" value="XM_022246621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9G9"/>
    <dbReference type="GeneID" id="110985539"/>
    <dbReference type="KEGG" id="aplc:110985539"/>
    <dbReference type="OMA" id="QENTHES"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002366">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="579"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="632"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="712"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="296"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="592"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="908"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022102313.1"/>
        </source>
    </evidence>
    <sequence length="1144" mass="126554" checksum="29AD09915609711F" modified="2022-01-19" version="1">MTMGQITNHMSADATNVMMMMQFMHFLWSAPFQIVIILILLYFEIGFSALLGAALFIVVLPIQFKVAAIMADKQKAILRCSDKRLKLTNELLQGIKLLKMYAWEELYSKAIEVVRKEEVRNLLYINLCTITSVSITFGVPILVTLIAFITFEPISGRPLTPDITFSSLSFFNLIAIPLFMIPVSVSAIVGSIVSSKRIMKFLLAPEVEGDRALPMDIKGKTHSQEKKGYSDESRVVFRKLDEVLSESTVSIGTQTDDSDDQTDNTERALMLNGISIPLGKDLNDASTSNSDQGIAIKITDGNFVWDPESTSPALSNVNVEIPAGKLTMVIGAVGSGKSSLLAAILNEMTTLSGNVHINEEKGRIAFAAQKPWLMNASMRDNILFSSKMDKKRYHKVLDACALVPDIDILPAGDKTEIGEKGINLSGGQKQRVSVARAVYADSDIIILDDPLSALDVHVGRQLFEEGIMKQLVSNNKTVILVTHQLQYLSRADLILEIKDGTIAASGSLDDIIKADPEMYEEIKQVSAAGWDDDQAESAEEERFKLQRRVSIASAEIAKGDGQLIEKEEMVRGSVSYKTYLYLLGSVGWGLILLVALAVALQSSLSVTNNFWLSEWSEAGLSNETTRTYTEYLVGYACLSVSAAVSQSLSATILILSFMVAARRIHLRMLRNIIRAPMRFFDTTLIGRILNRFSNDTQLMDFRLANTYNGFVISIMQIIVSVVVVGVVMPIFLVFVIPIAIVYYILQRYYLATSRELQRLDSTSKSPVFAYFSESLGGLTTIRAYRSENRFYNTILARIDRNTAAFLYVQIGARWLAVRLDLLGALFVLLSTGSTLIGALSFGINPSLVGLSSTYSLQMSNYLNYLMRNRTEVEMQMNAVERIQFYSEVDQEEYSGAEPSAGWPHSGEIRIDNVSVRYAEDLEAVLRNVSVYLKSGEKVGICGRTGSGKSSLTLALLRVIDIFEGRIFIDGVNIMDVPLATLRSKISIIPQDPVLFTGPIRTNLDPEEKVSDDEMWHALEIAQLKDVVSQLDGGLDAVVTEGGENFSVGQRQLFCLARAFLRKSYILIMDEATASVDMETDKTLQTVVANAFAERTVLTIAHRIATIRDADKIIVLDGGRMVEFGSPEELLTDEDGVFTSLVRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAP3</accession>
    <name>A0A8B7ZAP3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 16">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110985276</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PEX13; forming the PEX13-PEX14 docking complex. Interacts with PEX5 (via WxxxF/Y motifs). Interacts with PEX19. Interacts with tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 16">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 16">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101885.1">
        <property type="nucleotide sequence ID" value="XM_022246193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAP3"/>
    <dbReference type="GeneID" id="110985276"/>
    <dbReference type="KEGG" id="aplc:110985276"/>
    <dbReference type="OMA" id="YNQWQPP"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000296">
        <property type="entry name" value="Peroxisomal membrane protein PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="19">
        <location>
            <begin position="36"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="252"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022101885.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="38754" checksum="ACB5AA12C48E80E3" modified="2022-01-19" version="1">MASTDTPPDDQAKTTTVQQPETSVAVSSDTSSAVPRENMISTAVRFLQNPQVRSSPLAQKKAFLEKKGLTAEEIEMAIDRSGTRQDVVTAVAPAPAPSNQAAVPPQAAQMQQQQMVPYGQPAPPRLTSWRDYTALAIIIGGVSYGVYWLIQKFLMPFLRSRKEDQERLQKLEASVQELNKSVLLTVEKLDTAVTSIQGLLEQQQTKLDSLTTSVMTSRAITGSSNDNSNEIADVKAEITSLKGLLLNRHQFPATPQPAPIPAWQRVSPNSDSTLTKPQETQPPAQTADQETAGTKTAVTADSQNAAEVGVTNGDLGDFSHSEVLTNGDKSLNLNIHESGIARKDDSLGPIVNHMTSSQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC16</accession>
    <name>A0A8B7ZC16_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110985646</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022102515.1">
        <property type="nucleotide sequence ID" value="XM_022246823.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102517.1">
        <property type="nucleotide sequence ID" value="XM_022246825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZC16"/>
    <dbReference type="GeneID" id="110985646"/>
    <dbReference type="KEGG" id="aplc:110985646"/>
    <dbReference type="OMA" id="EEAYVWG"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000128">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044519728" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="24"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022102515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022102517.1"/>
        </source>
    </evidence>
    <sequence length="564" mass="62582" checksum="D87D6602DCF2CCE0" modified="2022-01-19" version="1">MEGFSLSFIILCILAVSAADEDGPVVHLGQSSAVKGFITRAVDSQTPVYNFRSIYYAAPPTGKRRFAPPARRKPFQGLSDATKFGPLCPQDIELTVKAFAGLPMPTWEMSEDCLHLNIHTPSLDVEAKLPVMVHFPGGAFANGGAGFYDGTALAANHQVVVVTVNYRLGALGFLSTGDSTLPGNYGLLDQGAALRWIASNIKKFGGDPQTLTIMGESAGAMSVHFHMLSHVNEKLFRRAIAQSGAANAPTALVRDPRELAEKLANAFHCPTENARAMVECLRQKPADKLGRVRLTKRPIEFGPVVDGFYLKDDPRAIQSKYQLPRKELLTGFNSDEGGQSILDTRGTKDFFENLSAKTFDTFLEELLYLTVPKDLPVKPLARAITKIYIGDRSLKDDDEARQTISDIVTDSMFVSPAITTANTLSHNGLSIFLYEYKHRSSFSSLPPWAKADHGDEEAYVWGEPFMEGRGVEPEKFTEEEKELSRTMMVYWTNFAKYGTPNGLSGADDDYHPVPLWPQYERSEKKYLNLGVSPWVSQGAKAEKVDFWNKLYSFWKLGRRKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCG3</accession>
    <name>A0A8B7ZCG3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zonadhesin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102525.1">
        <property type="nucleotide sequence ID" value="XM_022246833.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985652"/>
    <dbReference type="KEGG" id="aplc:110985652"/>
    <dbReference type="OrthoDB" id="9219625at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034204525" evidence="2">
        <location>
            <begin position="21"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="3">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102525.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="44998" checksum="4F6C119B9DBB332C" modified="2022-01-19" version="1">MRVTVATFLLLLIAEKVALAGKTRVVDGTRYVCKQVQAVCPHDLMFTGTVCGSNSITYPSKCDLVREVCRRDKHQTFDFSHVGPCTDADCPTHCRGEGFHYVCGIVGCRERTFRNLCHLKKVSSACKPERRIPLSFSYEGFCRNPGRILPNCTDADTPQIVRTDLPENLKRPTEPPIRPTSTTMKPTDAQVKPTTAVKQTDASIKPTDVPVQPTDIPVKPTNAPVKPTTAIKQTDAPIQPTDAPVQPTDAQVEPTQKTDAPVKVTDVPVVPTDAPLQPTDTPGEPTDAPDIQTDAPVEPTQKTDAPVKATDAPVEPTDAPVQPTDTPVEATDTPVQQTDAPVMQTEAPVELTDAPVKPTTEVKQTDAPIQPTXKTDAPCSLLTPLWNQLMPQIYRLMHQLNQLMHQLNKQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZD20</accession>
    <name>A0A8B7ZD20_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101086.1">
        <property type="nucleotide sequence ID" value="XM_022245394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZD20"/>
    <dbReference type="GeneID" id="110984842"/>
    <dbReference type="KEGG" id="aplc:110984842"/>
    <dbReference type="OMA" id="VQVYQGY"/>
    <dbReference type="OrthoDB" id="9972248at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03670">
        <property type="entry name" value="NUDIX_ADPRase_Nudt9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000021">
        <property type="entry name" value="ADP-ribose pyrophosphatase, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039989">
        <property type="entry name" value="NUDT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030:SF8">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13030">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25969">
        <property type="entry name" value="NUDT9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="181"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022101086.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="38175" checksum="C6B476BE81E59B7D" modified="2022-01-19" version="1">MRLRLATLHVLYFPLGKASHKNIADTKTSINRFLAGLVFCSRFLIEQVPKMALTTSASRLPLHVKARGERYPNSDVKRFPVPDDKVQWSVPWPEYKPVEFTNPKVLAGPVWADPEIRGPNSVKLKFNRVDGKINRRSHMKPDYETPEGVPRNPCGRTGITGRGELGKWGPNHAADPLVTRWKRDESGTEVVDPVTKKKILQFIAICRKDSGAWAIPGGMVDAGETVSVTLRREFGEEAMNSLDAPRKERKKIEKAVGELFKHGIEVYRGYVDDPRNTDNSWMETIAVNFHDGTGNSVGKFALHAGDDAGAVQWTDIGSNLKLFASHESFIEKVAIRLDAHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDS2</accession>
    <name>A0A8B7ZDS2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Geranylgeranyl transferase type-1 subunit beta</fullName>
            <ecNumber evidence="4">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Geranylgeranyl transferase type I subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Type I protein geranyl-geranyltransferase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110985866</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Heterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.59" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022102985.1">
        <property type="nucleotide sequence ID" value="XM_022247293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDS2"/>
    <dbReference type="GeneID" id="110985866"/>
    <dbReference type="KEGG" id="aplc:110985866"/>
    <dbReference type="CTD" id="5229"/>
    <dbReference type="OMA" id="RWCLMRQ"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02895">
        <property type="entry name" value="GGTase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000005">
        <property type="entry name" value="Geranylgeranyl transferase type-1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041960">
        <property type="entry name" value="GGTase_I_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="16">
        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022102985.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41498" checksum="2AE860B5D75DD482" modified="2022-01-19" version="1">MAAPTDSQQTEQTRQKDILFLRAKHIKFFSRCLQILPQSYTSLDTSRLTVCFFALSGLDVLDALDTIEKDRQDIIDWIYSLQVLPDPNNYEETSKQCGFRGSSTIGTAYNPSRDTPSHSHPYDWGHIAMTYTGLACLLILGDDLSRVNKPAIVAGLKALQLQDGSFAATLNGSENDMRFVYCACCISAMLQDWSGIDVEKAVDFIYKSLSYDYGLGQGPDQEGHGGTTFCAIASLVLMGRLESTFSKRQREKIKAWCIKRQHSGFQGRPNKPVDTCYSFWVGATLKLMNGYDFVDFACNRAYILSTQDEMVGGFAKWADYHPDALHAYFGICGLSLMGEPSLLPINPSLNISQRAADHLQRVHDNWKAEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDW0</accession>
    <name>A0A8B7ZDW0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103844.1">
        <property type="nucleotide sequence ID" value="XM_022248152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDW0"/>
    <dbReference type="GeneID" id="110986350"/>
    <dbReference type="KEGG" id="aplc:110986350"/>
    <dbReference type="OMA" id="LSYKHCA"/>
    <dbReference type="OrthoDB" id="10066544at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033772">
        <property type="entry name" value="UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF41">
        <property type="entry name" value="UNC5C-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17217">
        <property type="entry name" value="UPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="3">
        <location>
            <begin position="208"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022103844.1"/>
        </source>
    </evidence>
    <sequence length="704" mass="79622" checksum="B1598F2365058390" modified="2022-01-19" version="1">MGPYREHFGDDDNKDVVDPPTDCARINGTDIVIIVLAVFGSVFLLAVITCILRCICRKWFGRSCRIVWETDNLSNSYRVDNDFEDVVICDSQPRGREMFGFNRGFTPATDNPIYTIPRPKISGDQGMFLENWEFGKRLQPRIEDTCSGQYRYTYDGQLRSPPVANSSSVTLRTSEGEASFLKDHQLQELQRAGMTRSETIMVGSKLVVFISREVSHLGDTLVLTDMGISLTVPPYAIEAGRTELISLILDWDLGDFPEMTDEETIISPVVHCGPHGLKLNKPAVLSYKHCAYDRGDVSLVASQTHLMQSKDWYQVCERDDYNKPYTLLTNEVQIQISHFTLYTCLADGKTATKKWMQLAVFGGKMRPKRHYEIRIYFLNNTPCALQFAIQNEAKNHFRLLCPRKEFLFHGDGKDTVATVEHISEGWSHRLDDRRELVPFLSLWHGKCPSVSFIFKHENEHVRDIDIRLSVCQRDREDKESEKTNLKVLASMRSPPSKHDSDRSIGKTGTVIKVFPPSRRSKRRRFDSESGRSHSDSFRSASTEATSSSESSCTSSCSTLPTSDTSSNIDSKSESEDQVTGSQNCVQNMQIHIHQSPDNLPRVTTQRTIPHELCMELVVLLDPLAPLGNDWRVLASALEMDCLIPLLKSTPSYNPTETLLEEVERQTKGLEWMASVMMKAKRLDAANVIMKYADTPGNSCARNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEJ0</accession>
    <name>A0A8B7ZEJ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Selenoprotein Pb-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110985140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101631.1">
        <property type="nucleotide sequence ID" value="XM_022245939.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985140"/>
    <dbReference type="KEGG" id="aplc:110985140"/>
    <dbReference type="OMA" id="DRCGFLT"/>
    <dbReference type="OrthoDB" id="6134775at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001887">
        <property type="term" value="P:selenium compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007671">
        <property type="entry name" value="Selenoprotein-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037941">
        <property type="entry name" value="SeP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10105:SF2">
        <property type="entry name" value="AGAP003297-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10105">
        <property type="entry name" value="SELENOPROTEIN P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04592">
        <property type="entry name" value="SelP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0711">Selenium</keyword>
    <keyword evidence="4 10" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033996659" evidence="7">
        <location>
            <begin position="25"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein P N-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="10">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022101631.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="29964" checksum="5F6FBBE80CEF6C0D" modified="2022-01-19" version="1">MGPAARRVPPLLAALLCVAHLACGAAGRVLVDPFASPLRCVTPPAWSSRGVNPMEAGRGNVTVVALLQASUHFCLSQASGLETLRHSLAQDGLLDINFLVVNSWNAWLHAYKLRELVTFPVYQEGFFSSIWNALFGRKDDILVYDRCGFLTYHLSMPYSFLTYPYVEGAIRVTYHGDDPCNCTLGVNLATTVTPSTVADNKTVDSNETLNIEGDFEGLNVTSNSSGEFEVAANTTVTSTPSTSDNHTQGNVTEVEPVNLKKQHRHHGKKYDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZG01</accession>
    <name>A0A8B7ZG01_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium channel subfamily K member 16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110986320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103790.1">
        <property type="nucleotide sequence ID" value="XM_022248098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZG01"/>
    <dbReference type="GeneID" id="110986320"/>
    <dbReference type="KEGG" id="aplc:110986320"/>
    <dbReference type="OMA" id="AWERDAF"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="184"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022103790.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35376" checksum="421546430997BF07" modified="2022-01-19" version="1">MKPLPRRLIKTIILSVCFYGYLMLGALTFQATEAEPHRNLLKKSRRQLLRALQNFTDANQGCGVAMDRVRALLQAANNAWERDAFLVDPSNGVQPVWNLVDSMAFSLAVVTTIGYGDLVPRTTGGQVFCTLYAAAGVPLCYYMLMVVGKTFRTAWVTLFNCFANLKHRVGRRILYLIMPLTSLWIFLAVIPSLTLMQTEGWPYLTAQYYSFVTLSTIGFGDEQPRRTSPYTGYAYSIKVIFIVYILLGLSIISITFSGVSMALSEFREKTKRKRKCALHREQIEDHVAVTNDPSVTPLSYRQRVPIQSAVTSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZH17</accession>
    <name>A0A8B7ZH17_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 7">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110986924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPK1 type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 7"/>
    <dbReference type="RefSeq" id="XP_022104943.1">
        <property type="nucleotide sequence ID" value="XM_022249251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZH17"/>
    <dbReference type="GeneID" id="110986924"/>
    <dbReference type="KEGG" id="aplc:110986924"/>
    <dbReference type="CTD" id="64768"/>
    <dbReference type="OMA" id="CHMEADF"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022104943.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58190" checksum="9CDA920CBCA6A1FE" modified="2022-01-19" version="1">MACNGTDPVLSVQDWHYRAEGNTSFVIFNPKTRTILKLRKRCVSKDSCLKVVADDVQPFQEFIETAIKPLLGNKFISLATIIPVNRDFLETLAKYFEPLRPVKRLNTQVDVSKQYALCLPDFSFLRYPKKLQSDGPTFCIEIKPKRGFLPLPGQIPRDLAIKYSVCRYCLLQQFKVQQGIWEKRSHYCPLDLFSCDPSRMKYSLNMLLENPQNNLRIFKDGVAIYHVQEKSTPSEAEQRKLAEQLQQYFGDTGAEEDTKDHLLQSSCVQSFLDIIIRALLSSNTKNGVKQTTRVYAPPHALPHAPQTCAESGYNSWPKEKYPTEVMSSPSENCILRKLLAAQSSSGLEIDVILPLYERVLHHLQSHPEDCEKYRLDFPYEGDSSCMDKDTKRCLSSLKERRANGKVDVSGVGIKDAVRLIRDYLIMRTLTDCSIMLAVQLVPPEKRSSLPWDALLVQSPKGQSYLYSALVVDLDPKPSSKIPTYESLDRKVALEYVKRHQNGSAEPSVVTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIG8</accession>
    <name>A0A8B7ZIG8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GDP-fucose transporter 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110987174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105354.1">
        <property type="nucleotide sequence ID" value="XM_022249662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIG8"/>
    <dbReference type="GeneID" id="110987174"/>
    <dbReference type="KEGG" id="aplc:110987174"/>
    <dbReference type="CTD" id="55343"/>
    <dbReference type="OMA" id="WWTSNIV"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="75"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022105354.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="44219" checksum="CA9E3852BD4BBCE7" modified="2022-01-19" version="1">MVKGVRGRARPGPRFGAGSEGVLSAESMSLSSSSELKPNGDGVGEGTAADKMATAPDAGGGGDGGGKSLVQKFVQIAVVVTAYWFISISLVFINKYLLSSQDLKLDAPLFVTFYQCCVTIMLCTMLGIMGSLAPSVISFPALKFDYKISREVLPLSVVFVGMITMNNLCLKHVGVAFYNIGRSLTTVFNVILSYAFLKQTTSLRAILCCCIIIMGFLLGVNQEDSSGVLSYIGVIYGILASLCVSLNAIFTKKTLPCVENNIWRLMFYNNINAVLLFLPLVYLSGEVGKVWDFPHLSSPHFWAILSVSGLFGFMIGYITGLQIKVTSPLTHNISGTAKACAQTILAVAYFQEVKTALWWLSNAMVLGGSALYSHVRRQEMTKEHAENLKAKAEEKEASNTLRSGKMISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKA0</accession>
    <name>A0A8B7ZKA0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 4H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110986289</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103741.1">
        <property type="nucleotide sequence ID" value="XM_022248049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKA0"/>
    <dbReference type="GeneID" id="110986289"/>
    <dbReference type="KEGG" id="aplc:110986289"/>
    <dbReference type="OMA" id="GPEDRGM"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12401">
        <property type="entry name" value="RRM_eIF4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034229">
        <property type="entry name" value="eIF4H_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="65"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="144"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022103741.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="31439" checksum="E1F6A09F9AB6AB1C" modified="2022-01-19" version="1">MSGFGENFNAFSGAAGNYPRGRDRDNDYGRGGGGHGAGGYSGGYGGGGGYSGGKQQKPLPTEPPYTAYVGNLPSDCLQGDLETIFENLAEKIRVVRLVRDRDTDSFKGFSYVEFDDLESLKEALQYNGALFEGKPLRVDIAYSKKSKDGGRGGFSRGGRGRGGPSRGGFRDEGNFSGDFRRGDRGPPAGDDGYYGGGGRGREDYGGSRGQRGGGYRDRGGFDRERTGRPDDFKEPDPADSAGRPKLKLQKRTVKDPVNQLADDVQRSSIFGRGKPREENLQKLEKPRGESAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLI2</accession>
    <name>A0A8B7ZLI2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane metallo-endopeptidase-like 1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110986554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104191.1">
        <property type="nucleotide sequence ID" value="XM_022248499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLI2"/>
    <dbReference type="GeneID" id="110986554"/>
    <dbReference type="KEGG" id="aplc:110986554"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="98"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="549"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022104191.1"/>
        </source>
    </evidence>
    <sequence length="756" mass="87376" checksum="A732AC82E1E0866F" modified="2022-01-19" version="1">MDGIVTKPNSVHWKRPSWYRRRTSLERRLLVLAVLLGFVALSLVAVLLHELMTDRKVSEGALKPGKSTQCIDQQMCLTDECVEAAAGLLLNMNPKVDPCKDFFEYSCGGWTKSRVIPEGSSKLTATTELKNRLELNCKGLVESDVTDDDIEAIAKTKYFYQACMDEERISSRGFEPLWTLIAKFGGWPLMNDTSFDESTWNLEDTLAKMYSETEQNFFFSNYIGIDPQNNEMHIYIIDQTRTLLSQEDFMVANFSHKNVVAYREYMEAVALELSLASEDEVRHQVLDMLRFEEKLINIKIPRGPSRVVLKRYKKLTVGDLQNSIPQFNWSRYFDAIVSPSFNDTELLGTYSLDYLKRLGTVLHETPTRTIANFLMWKLVHESILLLGRKSRKLREEFLYLVEGEHGEGPRWKQCVTMTANRMSSGMSTMFIQKYFGQQSKTMALQMISKLREAVQETLNETKWMDEPTKARAIEKLLAIREQVGFDETVNNYTVLEQDYNDVEISSQHYFENVFETLKNDVKFMLKNFRRAVNTDRYRWSKLFPPYKANAGYQYALNQITFPAGFLQHPFYNRRNPHSMNYGGIGMVIGHEIMHAFDDMGRRFDKNGDMSEMWTEASAQGFRRETNCLLEQYGNFTVEQVNRKVNAKLTLGENIADTSGLKVAFKAYRRWIAERGAEEPTLPGIRLTHNQIFFLNYGQLWCDKSRDQALIYQLQQDSHSPGKFRVWGPIMNSPDFSEAFHCKPGSPMNPAKKCSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLZ6</accession>
    <name>A0A8B7ZLZ6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2. TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 assemble in a 5:5:2:1:1 stoichiometry; each is associated with a gamma-tubulin, thereby arranging 14 gamma-tubulins in a helical manner. Gamma-tubulin at the first position is blocked by TUBGCP3 at the last position, allowing 13 protafilaments to grow into a microtubule. The gTuRC (via TUBGCP3 and TUBGCP6) interacts with ACTB and MZT1; the interactions form a luminal bridge that stabilizes the initial structure during complex assembly. The gTuRC (via TUBGCP2) interacts with MZT2A/MZT2B and CDK5RAP2 (via CM1 motif); the interactions play a role in gTuRC activation. Interacts with NINL. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106638.1">
        <property type="nucleotide sequence ID" value="XM_022250946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLZ6"/>
    <dbReference type="GeneID" id="110987835"/>
    <dbReference type="KEGG" id="aplc:110987835"/>
    <dbReference type="CTD" id="27229"/>
    <dbReference type="OMA" id="QLSMWLL"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000001">
        <property type="entry name" value="Gamma-tubulin complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="9">
        <location>
            <begin position="352"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022106638.1"/>
        </source>
    </evidence>
    <sequence length="662" mass="75660" checksum="E18ECE3BB45679A2" modified="2022-01-19" version="1">MLHELLLSLSGFPGSIFVNGENGTIKVVPDIPFLHRSEVSILNRLCILGTHYRRFREFIKEYSGSPSSSLDPSRDAPKDHLKLRDGLYLRAFCAGLDKVLDPYRKELLRLEQEILLDPHLTPCHIQEVLEPYQLLFPDLWAVIEQIRYQRGHGGHILEIVHQHCNCGKPMVKDAFQKILFVCHCVLYRQVTAWLLHGMLLDRHSEFFIHKSAVSSLVERQYDDDDLGIGGVTGRQMREVMQLNEDGRLPERPAHTLYAIRPAMLPSYIPVRVAEKILFVGESVQMFENRKQTVASKYTDSVLGDKEDIFASRFHQLRQEPLFSIKNFEDAIDGIRSCVAEHLWRLVVEESDLVGQLHTLKDFFLLGRGELFLAFIDHAQNLLKTPPTSTTEHDVNLAFRQAAHKVLLEDDTSLGQVRLTATSKTPIKGASKKSEAAPQSKSSGDIGWNCLGMTYNVQWPLHTLFNAAALEKYNTLFRFLLSIKRVQLELQQCWALQMQRKHAPAEQSDASKWRLRSHMAFLVDNLQYYLQVDVLETQFTQLIDKISSTRDFEAVRLAHDQFLTSLLGQCFLLMKPVSHCLNEIMELCHSFAVLLITHAASMTDREVTHMDKLSQGFSRQSSLLFKILSSVRSHHQASPHLSQLLLRLDFNKYYSQAEGALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM23</accession>
    <name>A0A8B7ZM23_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Mitogen-activated protein kinase kinase kinase 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13 14 15" type="primary">LOC110986656</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104389.1">
        <property type="nucleotide sequence ID" value="XM_022248697.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104390.1">
        <property type="nucleotide sequence ID" value="XM_022248698.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104391.1">
        <property type="nucleotide sequence ID" value="XM_022248699.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104392.1">
        <property type="nucleotide sequence ID" value="XM_022248700.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104394.1">
        <property type="nucleotide sequence ID" value="XM_022248702.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104395.1">
        <property type="nucleotide sequence ID" value="XM_022248703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM23"/>
    <dbReference type="GeneID" id="110986656"/>
    <dbReference type="KEGG" id="aplc:110986656"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06625">
        <property type="entry name" value="STKc_MEKK3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000071">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="430"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022104389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022104390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022104391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022104392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022104394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022104395.1"/>
        </source>
    </evidence>
    <sequence length="695" mass="76840" checksum="FC2E0ACC73F94A0F" modified="2022-01-19" version="1">MADKGKEEVIQEITSELVQALKESGTRNNKSVKTSSTQTNEVRVKFEYQGERRILQVPRPLNYNDLLTKARTAYGVPVDMHYTTNDVNSNIVVPIKSQTNLNQAVALMDHNPTAKSLRIYLTPIQTGTSTATVATTTVGGYHKVASSPEILASLSGPGSGSVTYHESVTGGGELYDTAIRSDSTHKPTTLRSQSIPQAPTPKVPQNLTNKRHSTPVEMPARDTPSPPPGHVPTESMQDIIRDSTCGEGRFIPEPESEQQDHVMISSPNGSHQSLDKPFYGGSQSLGSTSGRMFRAQSTNSYEEFSSSQYPERSGKGGTFPTRYSMKNSQTEYDDGRKTFPSRSRRPQLSPSLMSRGSGEERSEAYSPHGSEHSLSKSSSSSGIGADYDTLDSRRRRDSELEHSIKSLQEMGLKENAKCETMMSPRAPVNWRKGKILGQGAFGVVYLCYDADTGRELAVKQVPLDNNNTEARKEVKALKSEIELLRNLHHDRIVQYFGCSEVRDVLSIFMELMPGGSVKDELRSYGPLTENVTRKYTRQILEGVAYLHISHIVHRDIKGANILRAGSGNVKLADFGASRRLQTIASYVTGIKSVTGTPYWMSPEVINGIGYGRKADVWSVGCTVVEMLTTKPPWADYEAMAAIFKIATQPTIPQLPSTVSDVARDFLQLMLIRDPQQRPWSHELLRHEFVNNFSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM86</accession>
    <name>A0A8B7ZM86_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin domain-containing protein 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106182.1">
        <property type="nucleotide sequence ID" value="XM_022250490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM86"/>
    <dbReference type="GeneID" id="110987622"/>
    <dbReference type="KEGG" id="aplc:110987622"/>
    <dbReference type="OMA" id="FCCLCCG"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="196"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106182.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="45615" checksum="A9FA98FBE657A928" modified="2022-01-19" version="1">MLCTDERHILHNANAVMGKISGFQIIFDNDQEVFNGGDVIQGHVRLDLQATKQFRGIYMHWKGRAVVTWTEIEPRGKSKVTVLYVAGEDYFDQYITIWGKERTDTDESRLELPAGQHCLPFKFQLPTRPLPCSFEGTLGYVRYFARAVIDRPWTFDHVTKRAFTVSGIPYDLNKVQNPLAPVYNEDEKTVCCLCCATGPVSVSASTDKRAYLPGETIYISASLDNRSNRSVHSLEAELIQSVNYYARRDGVGSPSYRTTSHVVTSVVSEACGSYASAHWDRKPMIIPPLPPCNLEGCNFIDIRYYVKFTADVASTPFDVDLMLEIVIGTIPLSGHTYWNASSNQPTSSAGIPPTYEAAIGGQKEIRDEHDNEFVFGKLVYTPQYMFYRYHSVEEGHPSAIEKSTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNL2</accession>
    <name>A0A8B7ZNL2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Q2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107188.1">
        <property type="nucleotide sequence ID" value="XM_022251496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNL2"/>
    <dbReference type="GeneID" id="110988189"/>
    <dbReference type="KEGG" id="aplc:110988189"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000006">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 Q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="219"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107188.1"/>
        </source>
    </evidence>
    <sequence length="391" mass="44728" checksum="CCB0B9702DFFAD30" modified="2022-01-19" version="1">MACVASLKQELKLSESLFGKDNERFQIHAATMDELTCKFIGCNKEEFVVHCNFTDSYPQTRPVWFSDSDDPVLSTVLQRLSEISASGQLLLKMIRRLVRDLCKLHNVQEPSTMSILDQELPSEKSDDEMASADEDDGADDFAHEEDDDEDEEEEEEEEEEENQDMDDCMDHYEMEEEPSKSVTEKDDKDIDAENYAVLERLKSNQRRDYLKGSVSGSVQATDRLMKELRDVYRSEAFKKKMYCVELVNDSLYDWHIKILSVDNDSPLYADLKQLKEKEGKDHILLNMTFKENFPFDPPFVRVIFPVLTGGYVLGGGAICMELLTKQGWSSAYTVEAVILQIAATLVKGKARIQFGASKQRQYSLARAQQSFKSLVQIHEKNGWFTPPKEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPT7</accession>
    <name>A0A8B7ZPT7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Glutamate receptor ionotropic, NMDA 3B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC110987209</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105431.1">
        <property type="nucleotide sequence ID" value="XM_022249739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPT7"/>
    <dbReference type="GeneID" id="110987209"/>
    <dbReference type="KEGG" id="aplc:110987209"/>
    <dbReference type="OMA" id="NCGDLQP"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000078">
        <property type="entry name" value="glutamate receptor ionotropic, NMDA 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="643"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="835"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="22">
        <location>
            <begin position="444"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="23">
        <location>
            <begin position="463"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Solute-binding protein family 3/N-terminal" evidence="21">
        <location>
            <begin position="471"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="972"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1169"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="972"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="999"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1024"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1124"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="742"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="17">
        <location>
            <position position="676"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="17">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="756"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
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        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="SMART" id="SM00918"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
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    </evidence>
    <sequence length="1191" mass="131804" checksum="2040D6EAE5BE8BDF" modified="2022-01-19" version="1">MVSFQYCLAYKLLFNCLPAVIFLFNTRDVLSSKLQSVRVAVVSDDVTNFSLFHEQVLTAIHEVNSTEPGMALHLGPVVLSSHPNPMDVYREICCQLAGTDVSAVVVHADEPTQFSLSVAGGFLGVPVIGLSNRAFAFSNKEVHPLFLRLDVSVTNQAHVIKSLLQRNAWFNFSVVASEGEGSDAFVQSLRDQIQTPGWNIRHDVRFSSGEASSGRFLRNLANDDSYVVMVLHCSPQEAQNVFRAASEFKLLGKGHALIGTESLATSDPNILKDYPTGLLIVKHYDTAPLRDHLYDAFTLVARSAQRLKWDGDTRNISCWTGPDSNQLEYANNFYSTMTNTSLKGKIGNILFDQNGDLRDSSYHIMNLIENSSGIPAWKEVGSWKKGSMNLDTVVWPGNTMVMPVGVDTHKLIIATNTEKPFIFYSESNGIEGECTTGVQCLMAKRNSDRRDLEKAFEEFRRRPDGGNYSADLRCCTGLCVDLIERMSQDLNFKYDLYLVADENHGAVENGTWNGMVGDLINSKADAAISSFSITRERSTVIDFTAPFFHSGFSTLVAKRQRKQTLGAFLAPLHPNVWMLIFASAIVMAVCLTISEWNSPYGLHPRGRNRNSTFSFPSALTITFAILFSNTIKTKPPKCMTSRMLLNVWGGFSLIFFSSYTANLAAFLAGQMSYLSIEDINDPKLKNPTSEITIGTVTGSSIQNYLRSLNPNLDAFMENYIQHSTEQAIDNLKNGELDVFIYDSPVIEYRMANDPQCNLVSVGKPFGEEGYGIGVPKESPLRDTVSGKILEYELDGILEELQRKWFESTGCMKEDILDPTSGGEDNTVTIAHVGGLLLLLVAGTIIACLILLVEIAAHKWLVPYLRKLPKHRRDCLVLSQRLHHEINSDFKVRSSANIRDLLTLVRQGEFGKMLQKEQRPAAPEEIEARRDIRQAVQAGIARRAPLSSSSMPFLHSSDQLEYLRTMDECIEDRKRPRGGREKNSWRHLDDFPDDTDETEMDKLIFRGRPTPEQHSDAALNHPSGVKQSKTTPPNETRINMVSGTSTQGGTTGIEPSPEAAHTLNCNIAEMDIGALSDADGTITFHCHRDSFASATYETDDLLSFMSDELAQSHLGRACLASTETAGGTISQGQSSASSDTEEPLPSEVHILSRNSSLPSYDSAMFYPSLVCPPSSDNTPEKTTKSLTKLDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPZ6</accession>
    <name>A0A8B7ZPZ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Uncharacterized family 31 glucosidase KIAA1161-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13 14" type="primary">LOC110988155</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107115.1">
        <property type="nucleotide sequence ID" value="XM_022251423.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107125.1">
        <property type="nucleotide sequence ID" value="XM_022251433.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107132.1">
        <property type="nucleotide sequence ID" value="XM_022251440.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107141.1">
        <property type="nucleotide sequence ID" value="XM_022251449.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107151.1">
        <property type="nucleotide sequence ID" value="XM_022251459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPZ6"/>
    <dbReference type="GeneID" id="110988155"/>
    <dbReference type="KEGG" id="aplc:110988155"/>
    <dbReference type="OMA" id="VWDEFLL"/>
    <dbReference type="OrthoDB" id="10070917at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06592">
        <property type="entry name" value="GH31_NET37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="312"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="623"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022107115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022107132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022107141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022107151.1"/>
        </source>
    </evidence>
    <sequence length="707" mass="80999" checksum="0C647C98ACB30DB0" modified="2022-01-19" version="1">MHSKYSYEDSPGPLNSTPLSASRKTPSVDKPLSRGPCYLRKKTRHGLMAFFVAVLIFALLAWYYVTQHGRMSFVAIGPMSFDPQGRVVILSDAEGQTVFRDKVGMNLPEGAELQDCTKEADSLNSLCLTWINVTLQDESPLAEMDIEYVVLKNNIKCINVDWTALRLNFAPLDCISLNDSHWYGGSIVHSQHWVLEKLRISMQPYVSGDIVSERNAFGSVLERYWLSSRGVAVFVERDTPLHVSINEKQTNRELCFKAEYFNSPYQNPTNKHASLKYTVCMGEDVRKVHEYILQNYFSRPPGLPDERMFRWPIWSTGARYHVNINQSAVIEYADEINHHGFPNSHIEIDDKYTLHYGDVDFTQTKFPNAREMIEDLHDKGFRVSAWTHPFANIDSPTFRKGISHNYWMREPSGRVPALIKWWNGIGAILDVSDEGAANWYIGLLRKMQTDYGLDSFRFDAGEVSYIPFIYNATVPFNDPNLYCTQYVELVSTINQQINVRCGHQTQHQPVFVRMVDRDANWNYNNGLLTVIPTALLMGILGYPFILPGYVSTNVYSVDVNHPNRELYIRWVELMAYLPSMQFSVAPWQYDEEVIRIAHKMVKIHEDVVTPMIFNFSSEVITKGYPVIRPIWWIAPTDKVAQHIDSQFLIGSAYLVAPVLTQHARARDIYLPAGNWKEELGKQTILAGGMWLKDYPVGIDEVATFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQB2</accession>
    <name>A0A8B7ZQB2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase member H-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987308</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105616.1">
        <property type="nucleotide sequence ID" value="XM_022249924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQB2"/>
    <dbReference type="GeneID" id="110987308"/>
    <dbReference type="KEGG" id="aplc:110987308"/>
    <dbReference type="OMA" id="SCANNAC"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF178">
        <property type="entry name" value="LIPASE MEMBER H-A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Lipase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105616.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25459" checksum="27D38A8378AF5275" modified="2022-01-19" version="1">MKELKDQLLTTENLNVFIVDWGAGARNLYGQSVQNIRVVGRVIARFMQFLNTQTGANFARMHLIGHSLGAHIAGYAGAFQPGIGRITGLDAAGPNFSGNDPACRLDPTDAIFVDAIHTDAEVLGLGIVQPVGHMDFYPNGGKEQPGCPATVGDVILDPMEVSCSHSRVLQLFTDSLNSSQCQFISYPCRSWDDFVDGKCNDCGLMGCPRMGYWADLSLASGSFYLRTGQGSPFCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTU8</accession>
    <name>A0A8B7ZTU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box only protein 16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106911.1">
        <property type="nucleotide sequence ID" value="XM_022251219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTU8"/>
    <dbReference type="GeneID" id="110987996"/>
    <dbReference type="KEGG" id="aplc:110987996"/>
    <dbReference type="CTD" id="157574"/>
    <dbReference type="OMA" id="CAQVCWY"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22172">
        <property type="entry name" value="F-box_FBXO16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052805">
        <property type="entry name" value="GEF_Ubiquitin-Prot_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46857">
        <property type="entry name" value="EPITHELIAL CELL-TRANSFORMING SEQUENCE 2 ONCOGENE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46857:SF2">
        <property type="entry name" value="F-BOX ONLY PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="90"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106911.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="44059" checksum="2930061C20E71858" modified="2022-01-19" version="1">MAWSGEQKRLENKKKNLDSKIRFSAWTPMNHAPTNDKVYEERKDVLRKWFDRWNDSQRRASIVEIMERCSLGQLQFMKQIAVSKLPIVCQDFARELPRAICLYIFSFLDPRSLCRCAQVCWYWKYLTELDQIWMPKALRLGWYLTFSPSPYETGVWKRHYLENVRSLHYVNPKESKVPASLEMNGNTTESPKTEKTSKRATPKLRSRPPKPLDHKPWRVNDPVADNLRRNNYLDNPDEILQQRQKRLERSKHVRERRNSASASDLTKDSEMAVKKTRASVNMAYKLKKAKSSSNIAGDDKPASNLAPDRPMWAQNVGNLHPDMLVTANTVGGKDASRRPPPLTKNIPPSAAVRRNERDLPEGDLFPTRGWQQIDVSDDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUL2</accession>
    <name>A0A8B7ZUL2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">N-acetylglucosamine-6-sulfatase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC110989212</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109101.1">
        <property type="nucleotide sequence ID" value="XM_022253409.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109103.1">
        <property type="nucleotide sequence ID" value="XM_022253411.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109104.1">
        <property type="nucleotide sequence ID" value="XM_022253412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUL2"/>
    <dbReference type="GeneID" id="110989212"/>
    <dbReference type="KEGG" id="aplc:110989212"/>
    <dbReference type="CTD" id="2799"/>
    <dbReference type="OMA" id="GMRFDNC"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012251">
        <property type="entry name" value="GlcNAc_6-SO4ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036666">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665757" evidence="8">
        <location>
            <begin position="20"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036666-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022109101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022109103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022109104.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="59744" checksum="BF25F002A56706A7" modified="2022-01-19" version="1">MDHLWRICVVMSLVITVYGNGKRPNIVFILTDDQDVTMNGMTPLVNTVSLIGKQGITFNNMFVSSPLCCPSRSSIFTGNYVHNHKTLNNSISGGCSNKNWQSGPERSTFATYLKGMGYSTFFAGKYLNQYGTKLAGGVSHIPPGWDEWNGLVKNSKYYNYTLSVNGKAEQHGDDYHHDYLTDLINNRSHEFLEKQSESTPPFFVMVSTPACHAPFDSAPQYVQNFTKNAAPRGPSFNKAGKDKHWLIRHAPNPMAKSSVTILDDVFRKRWRTLLSVDDMVKNIVDTLDSKKLLDSTYIIFTSDNGYHLGQFSLPMDKRQLYEFDIRVPLLVRGPKIKAGTVTDHIAVNIDIMPTIVHLAGDPAPQNVDGISLVPILIPNITESDEDKRDCLTKNKEENTVEDCPNTDPHTSPAGSRDFLIEHSGEWLPHGDFGCKNTDLCADCFPNCVCEDSKNNTYSCLRSIHPGVSSMYCEISDSESFQEYYDLNKDPHQLTNTIKSVKPPDLAAMHKLLVLLQLCKGDNCRQLIPPHTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUT0</accession>
    <name>A0A8B7ZUT0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110989323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109318.1">
        <property type="nucleotide sequence ID" value="XM_022253626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUT0"/>
    <dbReference type="GeneID" id="110989323"/>
    <dbReference type="KEGG" id="aplc:110989323"/>
    <dbReference type="OMA" id="HRYISIL"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000010">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="9">
        <location>
            <begin position="68"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="10">
        <location>
            <begin position="269"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022109318.1"/>
        </source>
    </evidence>
    <sequence length="464" mass="52908" checksum="73901111283614C8" modified="2022-01-19" version="1">MSHKKHGNKDLSSVRARHASPLLALDRSIISRSWEEVGFEFWKQLCSEHGISPEGILEDFATNDTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSSYANLFNPENIYLSKHGGGAGNNWASGYEQGERLYEEVFDIIDREADGSDSLEGFVLCHSIAGGTGSGMGSYLLERLNDRFPKKLIQTYSVFPNQQEISDVVVQPYNSMLTLKRLTQNADCVVVLDNTAMNRIASERLHLSNPDFTQINQMVSTIMSTSTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTVSSDLKSNSVRKTTVLDVMRRLLQPKNIMVSTTLRDRQSNHCYISILNIIQGEVDPTQVHKSLQRIRERKLAQFIPWGPASIQVALSRKSPYVQTAHLFERTCQQYDKLRKREAFLEQFRKQAIFKDNLDELDNSREVVQQLVDEYHAATKPDYISWGTQQSFGTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXE7</accession>
    <name>A0A8B7ZXE7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Hyccin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11" type="primary">LOC110989774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Hyccin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110084.1">
        <property type="nucleotide sequence ID" value="XM_022254392.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110085.1">
        <property type="nucleotide sequence ID" value="XM_022254393.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110086.1">
        <property type="nucleotide sequence ID" value="XM_022254394.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110087.1">
        <property type="nucleotide sequence ID" value="XM_022254395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXE7"/>
    <dbReference type="GeneID" id="110989774"/>
    <dbReference type="KEGG" id="aplc:110989774"/>
    <dbReference type="OMA" id="HAIYYAM"/>
    <dbReference type="OrthoDB" id="18937at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018619">
        <property type="entry name" value="Hyccin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220:SF1">
        <property type="entry name" value="GH21176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31220">
        <property type="entry name" value="HYCCIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09790">
        <property type="entry name" value="Hyccin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022110084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022110085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022110087.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="52542" checksum="2A5C60D1CD54DF46" modified="2022-01-19" version="1">MAEKKVQNWLTEYKFIDGTDVATFCGKIKNDVQLIKSIYEILQEPHSSLQEPVCGQLYEFYRSGHFELKRFCLQFVPAVIWIYLRGLALHKNYGRAESLLLGIYNMEVVEPDGISRIESFTVPTLAKPSIYHEPVSQLALTENVLSYQQSNHRLVTRGPLSQVNALTIKNRFSVLTHVMSEYNADIGFLSPVSHAFFCKICSNLVLCGFSGAHLAWKQSSSSDRVSKHNLNLDIHKTPRIPLDSTFMLEMLTGIYFVMFNGQASAGIHALEDIHFRANYELYADVLLVSNAIKHSLDTNPSGRPSDGPVGINVAVTPPSPVVKRSAITNASFKTRRQKETTITVTIEGVEKTEALAKRNGLSQEPSTNESASVLSSTELAYPQRKTHAQKCAPGVDVTIVDQSGSMKVETVEMEEVRLVLDVKQTKKDRNECNLSEASPDYPEIVPVSHVRELHSATHRSSNSSGESLETNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2V7</accession>
    <name>A0A8B8A2V7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990552</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111295.1">
        <property type="nucleotide sequence ID" value="XM_022255603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2V7"/>
    <dbReference type="GeneID" id="110990552"/>
    <dbReference type="KEGG" id="aplc:110990552"/>
    <dbReference type="OMA" id="SERAYNW"/>
    <dbReference type="OrthoDB" id="6782675at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF11">
        <property type="entry name" value="GIY-YIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="1">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111295.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="27870" checksum="5A03663E76E7ED24" modified="2022-01-19" version="1">MRVTVDVGGSLGHSVYRKPTHKDRYLHNSSFHHPRVKSSVIRTLIQRAHKNCKQEHLQDELQHISTALRLNEYHRRQVKTQNHLNFRVSYTQSQRPNYKDIVNPPFIGSTSHKIQRILNQASIKVYHSSIKKLQASLQTHKDKQDHKTKAGVCGIPCECGKVCIGETGRDLSTRVKEHTAHGCRGDYDKSAIVKHSHAEDHIIDWKAAELIVPVNRWHPRCIREAIEMCRHDTVPQNIGFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3I7</accession>
    <name>A0A8B8A3I7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110991258</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110991258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022112259.1">
        <property type="nucleotide sequence ID" value="XM_022256567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3I7"/>
    <dbReference type="GeneID" id="110991258"/>
    <dbReference type="KEGG" id="aplc:110991258"/>
    <dbReference type="OMA" id="TAIMPTT"/>
    <dbReference type="OrthoDB" id="9987373at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534:SF1">
        <property type="entry name" value="IGGFC-BINDING PROTEIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46534">
        <property type="entry name" value="IGGFC_BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="729"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="IgGFc-binding protein N-terminal" evidence="3">
        <location>
            <begin position="144"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022112259.1"/>
        </source>
    </evidence>
    <sequence length="836" mass="88235" checksum="390BA389C171FE17" modified="2022-01-19" version="1">MVYPLFRCPNPVSHVGVIFTVSILAFSLINVVFSSNSGRGHEFIFAFPTNFHEPSSTSPNYRPHLTLSVTASEAGATNVSMRVVNLDWSRQLTIPAQHVGITVELPPEAQAKGSGLQNTTVLVTASRNVTVLALSDSGESTGGFLVRSTDALGTDYFVVSYTPIVGEWSEFTVTATEDDTVVDINLKAPVMFDDEPYGRETLQLSLNRLQTAQFQSTLDLTGSRVSATRPISVVSGSSASNVPAEFGSAGHVVEHLPPVGAWGTVHALAPLLGRSSGYRCVVVAGCPMTMIRGFGDRVVLASAGDSFEWDASADRVAIVTSSKPILVVQFSKGLEADKSVGVDPGMGGPAMFTVQPIDLVTGPGALLSTPALPPGANHHISVTAMCKDIAGIMLNNSQIVPDHQYEYAELPGFCTVVKRVQTADSSPVISVQHTSPLGVLLAVSVMVHGTGFEGAYALSANLGAEVSPCETAGPDVCCNLEENFQLVSSLSYDEEGSMHSSDYEQYNSIPDLAIALRIADEGTATVQSLELTTAHNAPEPTGTKLYPTPPQTVGGRPTTQEITEDGENPTFATVEGLTVSDAEVTSRPTRASIDSSSQQPITSPTLSMPTTQEALTSTVSTPLESTQSSVSSASPSTRRATVAGTDQPGVGTDVPESTGLLPTFVRTSWIDSTPLTTQTHLSTGPSINDTLSTWLAATLRSTITPTTKEQTTEPGVDTRCPTCQTPFRILLYGGVAMATFILLCIIFCCLYIMRSKRTSKTAIMKRNSRWVAFPAAAVSLDELNLGRMKLKPAADDETGVGNTTPAPPSLTETEDVKVGTGGNLVTSGRTFKNSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3T9</accession>
    <name>A0A8B8A3T9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110990804</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111595.1">
        <property type="nucleotide sequence ID" value="XM_022255903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3T9"/>
    <dbReference type="GeneID" id="110990804"/>
    <dbReference type="KEGG" id="aplc:110990804"/>
    <dbReference type="OMA" id="ANIHYTC"/>
    <dbReference type="OrthoDB" id="5918951at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="11">
        <location>
            <begin position="92"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022111595.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15288" checksum="FF032638DD9B66D7" modified="2022-01-19" version="1">MLVQLLPRPRMRYTCSDDLSSASFSLAIEQSKNITSGRGKGGKGLGKGDAKRHRKVLRDNIQGITKPAIRRLARCGGVKRIFGLIYEETRGVLKVFLENVIRDAVTYCEHAKRKTVTAMDVEYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XFG0</accession>
    <name>A0A8B7XFG0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein inturned</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Inturned planar cell polarity effector homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110973186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inturned family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079494.1">
        <property type="nucleotide sequence ID" value="XM_022223802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XFG0"/>
    <dbReference type="GeneID" id="110973186"/>
    <dbReference type="KEGG" id="aplc:110973186"/>
    <dbReference type="CTD" id="27152"/>
    <dbReference type="OrthoDB" id="10038586at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043989">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043988">
        <property type="entry name" value="CCZ1/INTU_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039151">
        <property type="entry name" value="INTU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21082">
        <property type="entry name" value="PROTEIN INTURNED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21082:SF4">
        <property type="entry name" value="PROTEIN INTURNED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19032">
        <property type="entry name" value="Intu_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19033">
        <property type="entry name" value="Intu_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="221"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="701"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="772"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022079494.1"/>
        </source>
    </evidence>
    <sequence length="995" mass="110048" checksum="117A901A1EE0D93E" modified="2022-01-19" version="1">MATRQRNRGIPKSSSEPDGVSGSRETPRIVIEGEDFTGPSSADFRRDRPSAPARQVTSDRGFDSDSWSYSGSGSDGLEPAWAGSVQPSGELFYLEPGNDLHLADTLLTSQAAHQQAQADKSSQVAAKKKKNLAALQKIMRRKKGSNLVNVNNSADPSTNPKQRITGGKKSPHRTSVQRGTKPDRTVEVTLKVEAKQTLLNTQVDRLESWLGIVHAFDKKANVQNGASRNGHAHSAGEEKHNGRHAPTSSETRVFVRGLIPSGSAMKSGEIELGDIVVSVNSIPVFAETVNSVLASMNSASVFKLQLQRGSLGSWEKYIMPPQRPALNGSLVKLISGERLKEVEDPLRDVCHIISYLTLGREEDEEGKDILYEFPVTRASRKLSDIRGLFITLSDMLQNITDSAITSTSLVISGELVHIAYQKAGTEVLVMAVPASRVPMFLLDCIIKDVVRLLCFLFKNLDSAFQDSNYPRLNHLFSLLFQRLLLKENQQSQRTNSNTFLEGLPGARWLDLPEEVKINIDSSLSELEAADFADMSDDHYDDRRPYVLLGSCFFYKGYVTASHLPLGDLCDVTIYCRNYSLMVLSSQQPVGQLVIWREVYPTRRGEGSEPTVQGYTEPQGRWFLLIIGQGHSLLCLLMEAGGCASRCEGIPAPDPFYVDQARATLLHLESLNIPVACEERLSAPPIPALSCADWFFPSRKTAAESGTPPLPIQSSPMLSKLHSQSPARGRKLLQADSSSRRRSSSPGSMQLSTPSPVPRRHTTSRLDSDNESDTASPYNSRGNSTQSSPIPRRRNGERKGSDVSGGSVSSAELYKVARKKRLIPDPYNMGMMHQNQELECNDYFTATKLTAGCDNTLFHYIHLDAASGIITCPTHGDLSLIGGNTHAQLVQNFNRCCLTIRKLLCRSTRLKARPEESTRPIQSDHCMGYVREYGVMFKCQPENWQEQKKTPPSINYWVVGRLFEEPHPRECYVCYHESATQNVIELAFKLSYGAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XFP4</accession>
    <name>A0A8B7XFP4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110973227</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022079582.1">
        <property type="nucleotide sequence ID" value="XM_022223890.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079583.1">
        <property type="nucleotide sequence ID" value="XM_022223891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XFP4"/>
    <dbReference type="GeneID" id="110973227"/>
    <dbReference type="KEGG" id="aplc:110973227"/>
    <dbReference type="CTD" id="79053"/>
    <dbReference type="OMA" id="YHSTDFD"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022079582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022079583.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="60423" checksum="CEEA5CB3BA8CD06B" modified="2022-01-19" version="1">MAASMEYFGPLVMLITALKILLLPAYRSTDFEVHRNWLAITHSLPVSKWYYEDTSIWTLDYPPFFAWFEFALSQLAQQFDPGMLVVANLNYATQATVVFQRLSVILTDFVFVFAVKEYCSSLAKRCGRREYAQLLEKPQFVLAVLLVGNFGLILLDHIHFQYNGFLYGLMLLSLARISEGRNLEGAFWFAVLLNFKHIYLYIAPAYFVYLLRCYCFTRNNRDGGVQWTSLSFSRLFSLGAIVISVFAVSFGPFIAMGQLPQVLSRLFPFKRGLCHSYWAPNFWALYNVADKAATVAGLRLELLSAESLQDQAASMTGGLVQEYNHAVLPSVPPIATLILTVLTALPALLHLWRYPSGPRGFIRCLTLCAYSSFMFGYHVHEKAILLVIIPLSLLAMESLKDAQVFLIVSVVGHYSLFPLLFTQDETPIKLCLMLAFTIFSVIGTTHIHRYTNRFPNLLPNVPQLSTIETLYILGLVPLFIYKNLLHSMVPSLQRYEFLPLMLTSVYCALGITYAWLKLNVVTLGRGGGRLDKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGR9</accession>
    <name>A0A8B7XGR9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973438</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079974.1">
        <property type="nucleotide sequence ID" value="XM_022224282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGR9"/>
    <dbReference type="GeneID" id="110973438"/>
    <dbReference type="KEGG" id="aplc:110973438"/>
    <dbReference type="OMA" id="HHIFLED"/>
    <dbReference type="OrthoDB" id="5798273at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34717">
        <property type="entry name" value="EG:BACR7A4.20 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34717:SF1">
        <property type="entry name" value="EG:BACR7A4.20 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034504600" evidence="1">
        <location>
            <begin position="18"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022079974.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41744" checksum="61A02BAFAC04529F" modified="2022-01-19" version="1">MDVVVAALCVLAAPILAYVAANLASPDPLPLYGVYAIPGRWFWVKYHAMRLMLTLARRRTPHAGRRSVNPALMRQGEEKMSEIDIYPGIGDDPLGHNSFYVNGSDQTGATRLIARVAIRPDGRRDVWFLLRLPDLGDLVLPCHPHCVLTDVPGDGFSGGGLDCTVIEPLKKWKIVYNGPCRWSALTSYYDFTTDVHPRLAAHNLAKEKWTGQLFQKLKAMKQIHIEQFGTLEGVVRVGERSERGVVLTGVKDRSEGPRRWADLRSYVLNFIVLDPTGEIFPAVSVDLPLADLVEKTEDPPTTFALSMQPEVGEKLFVEVEIDDVMHFNMDTDWSVKIREGLSRFTVNGVKGTGVCEILKRYYGGCPVPLNKQSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHS8</accession>
    <name>A0A8B7XHS8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0193 protein EVG1 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080354.1">
        <property type="nucleotide sequence ID" value="XM_022224662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHS8"/>
    <dbReference type="GeneID" id="110973671"/>
    <dbReference type="KEGG" id="aplc:110973671"/>
    <dbReference type="CTD" id="84645"/>
    <dbReference type="OMA" id="MMAYGKD"/>
    <dbReference type="OrthoDB" id="189770at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007914">
        <property type="entry name" value="UPF0193"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28348">
        <property type="entry name" value="UPF0193 PROTEIN EVG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28348:SF1">
        <property type="entry name" value="UPF0193 PROTEIN EVG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05250">
        <property type="entry name" value="UPF0193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080354.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26074" checksum="6E8EAE49D1203622" modified="2022-01-19" version="1">MSAGKQRGVAKGGMWNTQTPQYSNETQQLLKVMMQESKLNAFQQRQLKEAMKGGGALPMRCNPTTSAKPCAPSAAKPKSIRVDPRGHSGGLRKKEDIEDSGAYERQQYRPSPQKSLEKEKGRLQNIMAFGEDKPPVTEERRKELLQAPTPEPEPDRFTELEAEIRERAEFLEDMTRLGKGKEYQAIIATEISQKLREMEVIDKKRTAQLHKAIQAKEQQTINPVPTEGGDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XI37</accession>
    <name>A0A8B7XI37_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110973232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110973232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079595.1">
        <property type="nucleotide sequence ID" value="XM_022223903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XI37"/>
    <dbReference type="GeneID" id="110973232"/>
    <dbReference type="KEGG" id="aplc:110973232"/>
    <dbReference type="OMA" id="YHESELQ"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000011">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000127">
        <property type="entry name" value="Thyroglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051093">
        <property type="entry name" value="Neuroligin/BSAL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43903">
        <property type="entry name" value="NEUROLIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034496056" evidence="6">
        <location>
            <begin position="27"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1143"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="30"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="586"/>
            <end position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022079595.1"/>
        </source>
    </evidence>
    <sequence length="1202" mass="131414" checksum="96796761EB3EF2EC" modified="2022-01-19" version="1">MASKHALGVILPTLLVFTASLHAGWAQTVITNTTLGPVMGIKVPYLPWTEQLVTRYTGIPYAEPPIGQLRFAKPVPKTPWDDVFNATVFGPSCPQPASNSTLTSFLPNDEIDEDCLLLNVYVPHDAVALSGPLSVMVFIHGGGLVFGQGMYYDGTLLALQGQVIMVNFNYRLGIFGFFSTGDDSAPGNYGLWDQRLALQWVKDNIANFGGDPDQITIFGESAGGWSVTLQMISPLNSNNLFQRVIAESGVVFPNLMIPADVARLQAFGLASALKCNPTTDSSSRSIIQCLRNVSMETLLIYTFAASTSPIIDGDFFPTDITSLLTHPRIGQYDLIMGFNDQDGSVLIGSVDTDGYTAEEFRAATGYFMQLCQCKTSHEITNAVFAYYFGADKLDDPMQNVVRYLDVTGDVYFDVASINFLTRHAQAAANTSTYFYHFTYETGRELFLPPEWLDVISGAPHALEIFYVFGFITAVYPNDTEAALLSNRTIEYWTQFARYGNPNGASLPEWPKFETENKTYILLDADIKTGHGFKSDRVAFWNDYIPTITDPTYEKTCTYELPIRSGTVQKPGTKTVQIESKDGEVLGSVIGTLEIADKAMGGREVAEFLGIPYAKPPLGDLRFKPPEDTGPWGDQPLGIPEKLPPACPQDVTLDPWMVRLGFNQTSEDCLTLNIYTPIQDSGNPALPVLVFIHSGDGISGTSSVYDATLLASQVEAVVVVINYRLGALGFLSTEDKVAPGNYGLRDIVAALKWVNKYIGSFGGDPEQVTLQGHGSGAVLTHFLVLSEKAKGLFNKVILMSATAISPSVNNPVLPVASEAAQALAIKLECPTTSTELIECLREKPVADIISSVVNPSFGLEFPPVVDGDLITDKPLELLKAGRINDVDVIVGLAKDQDAAQAFMMTSLDCPSVEEVEQYIEKVSKHSFNNPDEAAFTLNTEYIGKGGLGDDCETRGSFRQFMNDYLSYWSTLEAARLHANAGHSVYFYSFDLKPLAHYKGPLPPQAGPAFADDLQFLFGDPYSPLVDKLQLSYRLEDKQSTLELMEFLKKFLHTGVPGTSASGVEWPSFDSDNLKYMSLTDCPQAFSGVDNDWPHLLRFWASYLPSITAPVPPPPEVTPCPPDQEPCTVGESIGLKLTPEEASTIIQALIGTTVGALVLSVFFLGGCVAYKTRANQAEKQNARKKANKDLIYTESKEDENTFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XK29</accession>
    <name>A0A8B7XK29_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SHQ1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110973643</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHQ1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080308.1">
        <property type="nucleotide sequence ID" value="XM_022224616.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080310.1">
        <property type="nucleotide sequence ID" value="XM_022224618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XK29"/>
    <dbReference type="GeneID" id="110973643"/>
    <dbReference type="KEGG" id="aplc:110973643"/>
    <dbReference type="CTD" id="55164"/>
    <dbReference type="OMA" id="LNQDADY"/>
    <dbReference type="OrthoDB" id="73639at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06463">
        <property type="entry name" value="p23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000022">
        <property type="entry name" value="Protein SHQ1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="550"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="487"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="550"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="709"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022080308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022080310.1"/>
        </source>
    </evidence>
    <sequence length="756" mass="84448" checksum="92F44EF31A4AC762" modified="2022-01-19" version="1">MLTPAFELNQDADYLKILIKARYAKVTEVEIFVDGNDFKFYAKPYFLRLQLPGRVVEDGRERAKYDVDTGSFEITLPKETPGEDFQGLDMLTMLLAPRGQRSAEQPSIEVAGEGEEAGEACQAVEDDQGEIDWQVEQQPFQQDEDSLCSETNYGFANKRSGVFQRLQEELCDIVDVPRPDTAQLIERKEARQAVESEKFDGDHYLADLYQDDSVIEGLLSHKPSWHQEWRTLQAKSKQATNQKEPADKEEPIVLLTEDEKEQMRRLPRRHYLLSSETERSVLLSLVDIIFAYAYNIRTTLSEDSVESAWTICKLSPTLSWLDWFTSLDEMVTVCFRRALCYPLYRHWELTNKVFQDVKKIFALGRRRLLKCLLEVHRVLAADEPHYLLNELYITDYCVWVQTLSHNKITSLTEALKKVKISKSQVDFGLEELEQAAELAIQEDSQGQNDRGAVSSVHQYGYPHILYDGLESGSITQGTKSQAPLKQTECREETRHGNEAASTADLCTSNGSHDCSELGTYQKGDCAPVEDSSVTDVATKMADLKVCWDAGEKPSKSDEEQTRSFVSKEDVSVSLDVWTQRPPSKKIEMYGEDNPTPGSQSQSDSTKEDTDRRKDEESRPIVSGRNEGETEAIDDVTGSDSSLCGMLGCDDSMPVVDISESFLDAEVQHSEASTAGRELVGCDKSKQKHLQSQGPLDAVQTASQLESVTESSGNSESDSSEGSESGESGSASDSNEGSESEPELTKDAEPSGVSDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM12</accession>
    <name>A0A8B7XM12_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AP-5 complex subunit beta-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Adaptor-related protein complex 5 beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110974091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081146.1">
        <property type="nucleotide sequence ID" value="XM_022225454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM12"/>
    <dbReference type="GeneID" id="110974091"/>
    <dbReference type="KEGG" id="aplc:110974091"/>
    <dbReference type="CTD" id="91056"/>
    <dbReference type="OMA" id="SHHLEPF"/>
    <dbReference type="OrthoDB" id="646197at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030119">
        <property type="term" value="C:AP-type membrane coat adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038741">
        <property type="entry name" value="AP5B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048980">
        <property type="entry name" value="AP5B1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048981">
        <property type="entry name" value="AP5B1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048979">
        <property type="entry name" value="AP5B1_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048978">
        <property type="entry name" value="AP5B1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34033">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34033:SF1">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21589">
        <property type="entry name" value="AP5B1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21590">
        <property type="entry name" value="AP5B1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21588">
        <property type="entry name" value="AP5B1_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21587">
        <property type="entry name" value="AP5B1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP-5 complex subunit beta-1 N-terminal" evidence="5">
        <location>
            <begin position="42"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="AP5B1 middle" evidence="6">
        <location>
            <begin position="258"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit beta-1 beta-barrel" evidence="7">
        <location>
            <begin position="724"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="AP5B1 C-terminal" evidence="8">
        <location>
            <begin position="820"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022081146.1"/>
        </source>
    </evidence>
    <sequence length="923" mass="103287" checksum="74C2298923E0449A" modified="2022-01-19" version="1">MAARSGSVSESDRWLSEIVQFRKNSVTFLNTRQIEAGEFVLDILQALYSDKLGNTIRVVLLTILQEKASCLMSTPDSIEQTVGSLTSMYNQTTLETGAFYKSQLLVTVTTILLETGQLEAQPQLFTDLVELLLDTVSKVNRTADQTVRGTACQCLSEIETMHPGILMRKLEHIYAMSQLECTHICQNYMALFVQVLKNSIDILLKSGNRFHGSEVTDLLSSRTEPLKPLALPEDFSKKMFQLGSPPDSSLRCFPEDVDCKELLRCLSFLLDNLYLMTTACAVTTLLKLVDCMATSPQIAPHILRPFVTRVEASLDVALFHVVLMLKLRFGRELMTDAEEELLLDRLVSCSSHPCLMPGHRLLCYQWLLNFPENKVSVSDSESHLPAALDYSKTASLYPGVFDGLDTTLIKLNLLSLCFTPSHVQDSASTTLMGCLVPLQKSIHYGITGRPAVTLYRALYLYYRRHCDTVLREEIYKLIVTIVTEQPKFVPHTINFIECINRIDTNDSFPTELLQSSMENIVSTPPSDVIEDLEYHLLLLEKVCEEKSIPPKPVVVFLHQLLNSTSIAASGSWLLGNCILSVCHSIMQHHDTTDIFKESGQLLFELLTSYGDLDIRDRARFYYAMLTNISSQKISSILSSAGTTHSLTRLVTGSSNFDIPPPVQKLSEPVLCLTRIQRRPKCSTFAYSTCGQYLQELQSYSQPPAVHMDYYLHYTDADVTPSMDKLYTLVLHVDVPKSYREIPDVALSCLVLEESRQPSDTCQVISLPIQPLEPVPSKLPVSVVFMTADGQTSTGSLSPVHIQFSDLYLPMPVSSSDRPGLFDALWKHIQNHSSGMCAESVCTLLLSKAAMLGVIQDQLQDYRINHDAKEDVARIGIFLPPSWHVLLKVTTKQDMAVVAIATDNWKVLPLVDSFLHQLEESCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSB3</accession>
    <name>A0A8B7XSB3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110975510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022083748.1">
        <property type="nucleotide sequence ID" value="XM_022228056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSB3"/>
    <dbReference type="GeneID" id="110975510"/>
    <dbReference type="KEGG" id="aplc:110975510"/>
    <dbReference type="OMA" id="NKIALPW"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060169">
        <property type="term" value="P:negative regulation of adenosine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000057">
        <property type="entry name" value="Adenosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF43">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022083748.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="40340" checksum="792A400704EAF7DA" modified="2022-01-19" version="1">MQVESKSMLPPKVELHIHLDGAVRPSTVWDLAKKRGINVPGSNAKEMTSSIRNFEMGTLPKFLDTFKIFLPPLIGDKEALRRISYEICEDKAKEGVVYFEARFSPHLLVYSDPESGHVKEKALSTHDVMRSIVEGIEQGQKDFNVKARLIICTARETPAWALECLQLCQEFSEFVVAIDIADCGGKDETEGEEYHHEIIRVFQEAERCGVHRTVHAGESGPAGNVKIAIEELKAERIGHGYHVLEDDDIYQMVKDKDIHFEICPTSSVYTGSCDSDFTKHPCVRFIKDQINFSLNTDDPMVFGNTINDEFEIARKYFGLSDEQAIQVTFNAARASFLPKQEKLELIEKLRAAYHVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTJ2</accession>
    <name>A0A8B7XTJ2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110975287</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29092"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. Interacts with RAB5IF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="RefSeq" id="XP_022083330.1">
        <property type="nucleotide sequence ID" value="XM_022227638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTJ2"/>
    <dbReference type="GeneID" id="110975287"/>
    <dbReference type="KEGG" id="aplc:110975287"/>
    <dbReference type="CTD" id="4723"/>
    <dbReference type="OMA" id="QGDGKPH"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="374"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022083330.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="52026" checksum="10A28791B4551A7B" modified="2022-01-19" version="1">MALSSKLSVLLRGNFGRLPSPSTCCLSVASRQNSTDAPIKKYGPLKDQDRIFTNLYGRHDWRLKGALARGDWYKTKEILLKGHDWILKEIRDSGLRGRGGAGFPTGMKWGFMNKPSDGRPKYLVVNADEGEPGTCKDREIMRHDPHKLVEGCLVAGRSMGARAAYIYIRGEFYTEASNMQIAIKEAYEAGLIGKNACGSGYDFDVFMHRGAGAYICGEETALIESLEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVAPSICRRGGSWFASFGRERNSGTKLFNISGSVVNPCTVEEEMSIPLRELIERHAGGVTGGWDNLLGIIPGGSSTPVIPKSVCDDVMMDFDALVAAQTGLGTAAVIVMDKSADIVKCIARLITFYKHESCGQCTPCREGTGWMEKVMDRFVTGNAKPDEIDMLYELSKQIEGHTICALGDGAAWPVQGLIRHFRPELESRMQRFHEQQQKQKAAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUJ6</accession>
    <name>A0A8B7XUJ6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acid ceramidase</fullName>
            <ecNumber evidence="6">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110975940</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the acid ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022084519.1">
        <property type="nucleotide sequence ID" value="XM_022228827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUJ6"/>
    <dbReference type="GeneID" id="110975940"/>
    <dbReference type="KEGG" id="aplc:110975940"/>
    <dbReference type="OMA" id="IWELELM"/>
    <dbReference type="OrthoDB" id="5273684at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017064">
        <property type="term" value="F:fatty acid amide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01903">
        <property type="entry name" value="Ntn_AC_NAAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.60.10:FF:000006">
        <property type="entry name" value="N-acylethanolamine-hydrolyzing acid amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016699">
        <property type="entry name" value="Acid_ceramidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029130">
        <property type="entry name" value="Acid_ceramidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029132">
        <property type="entry name" value="CBAH/NAAA_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583">
        <property type="entry name" value="ACID AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28583:SF1">
        <property type="entry name" value="ACID CERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02275">
        <property type="entry name" value="CBAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15508">
        <property type="entry name" value="NAAA-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017632">
        <property type="entry name" value="Acid_ceramidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Acid ceramidase N-terminal" evidence="21">
        <location>
            <begin position="90"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Choloylglycine hydrolase/NAAA C-terminal" evidence="20">
        <location>
            <begin position="188"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="18">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017632-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF15508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022084519.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="49510" checksum="8A361FE40FC1DBC9" modified="2022-01-19" version="1">MLRECWWPGAANSYCNRRSELGLRVVCDTVVEISPKRRNIKRPTMLVRVLAPLAVLVMVFAPSLGQDVYPYTDKVCRTDVQYPPADAKTKVPSFVLNLDMNPEDRWRPLMKNKSAELKAMINDIIDLVGAFFKNKTKVVNLLDEVLGPLAYTLPQPYQAELIGIADASGVPLGQIVLYNIFYEVFTVCTSIVAESPNGTLYHARNLDFGLFLGWDVKNQKWELTERLRPLVVNVDYQVQGKTVAKAVHFAGYVGVLTGIKPGVVTMTMNERYNIDGGYIGILEWIMGKRSEQWMGFFMRETLLNATDYASTKAKVINAKILAPGYIILGGSKTGEGAVIVIDRKEPAYVEELDPKKGKWFLVETNYDPTEKPPFFDDRRTPALKCMTNTTQKAVGLGPIYNVLSTKPNLNLLTTYTAMMQVNSGYLETYIRQCPQPCYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVP2</accession>
    <name>A0A8B7XVP2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sodium-dependent multivitamin transporter-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110976174</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084928.1">
        <property type="nucleotide sequence ID" value="XM_022229236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVP2"/>
    <dbReference type="GeneID" id="110976174"/>
    <dbReference type="KEGG" id="aplc:110976174"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF28">
        <property type="entry name" value="SODIUM-DEPENDENT MULTIVITAMIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="328"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="409"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022084928.1"/>
        </source>
    </evidence>
    <sequence length="701" mass="76232" checksum="610999FDD6A60958" modified="2022-01-19" version="1">MLKLFRRIIVAFVIVVLVGLYFKHVDKTAPGSVKQPAARRERGVAGKMSGAEPNVHPFTWLDYVIFSAMLAVSACTGLYHACAGEGQKSTSKFLMADRSMMSLPVAISVIASYLSAITILGVPSEVFVYGIQYWMVCWSFFIAIPVSALVFIPVFHGLGLTSAYDYLHKRFSPLVRSIGALFFILQTLLYLAVVLYAPALALEAATKFPIFATVLTTGILCTIYTALGGIKAVIWTDVFQFIVLFGSLLTITIMGVIQAGGMKYVWTYNNDRGHLNFFNFSPDPTERLTFWGLIIGGVFNTLPVWAVSQTSVQRFLTAKNLKEAKRSVWFGLPGTVFVLTLVGLIGLVLFAYYNNLETSLVLANSTATTPVMKNDGPQPHYTPNYQSSDQILVYFVSLEFGNIPGIQGLFVACLFAGTLSTVSSGLNALAAVTLMDVVRPWRGPPKQRADSDASQEGSTNTANSATTSASTPLTSVAVNQAQDRWDTIISKILTAVFGVISIGLAFLASKLGSLVKTANTVVGGVGGPLLGVFSLGMLYRRANTGGALIGILVGFYLALWMTIGAATHQDENGNIKEDAFALYRVSFMWYSMFTSMATFLVGVIVSEIIRCCIPDERYKRVDPLLLATFLRPKGWHKSFPGTDSHNPDMRIGDPVFQSLLASGNQSVDQENESLLGDLEGNDIHELGSVINEVTDMRSAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVU2</accession>
    <name>A0A8B7XVU2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysosomal protective protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110975642</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083966.1">
        <property type="nucleotide sequence ID" value="XM_022228274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVU2"/>
    <dbReference type="GeneID" id="110975642"/>
    <dbReference type="KEGG" id="aplc:110975642"/>
    <dbReference type="OMA" id="VANKLWV"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904715">
        <property type="term" value="P:negative regulation of chaperone-mediated autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000335">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF201">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083966.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="56650" checksum="A3BB84BB0412DD30" modified="2022-01-19" version="1">MTVSKVLRAIYFEGFDIYSTLSKCPSMEWITTFIALLSLASISLYQASAASNPDIIKAMPGLLKQPSFDMFSGYLDGTGTKKLHYWYIESEHSVTDPLIIWLSSGPGCSTIYSALTSNGPFRVQPDGASLEYNPNSWNLNANLLYIDAPVGTGFSYSLDSSYASNDTEVTEDHFQALLSFFTKYPNSTLNVIYIAGDGYSGVYAPLLLAKLDSVSQKLPLQFGGIAIGNPHTSLVLQDNSLIYFAYHHGIIGDKLWSVLSMSCCPQGKCNFHNNTNKQCESAVNETVHDVLNIGINPYKVNGDCAGGVPVSSGMAGRDGFYHYPPGMQHIFAKSNLIQKQQKHIKGIPSWKLKADLTCINTTAVTKYLNDRDVRSALHIGDDFPTWEVCNATVDQLYTRQYPDMSSVYTDLLNTFKYRLLVYSGDQDATHNFLGNEWFVTNLRREAEVQWRPWLYKNADDQDQVAGFVKEYDNIAFLTIKNAGFWAPRDQPLATGLLIYNFINKRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW16</accession>
    <name>A0A8B7XW16_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-binding cassette sub-family F member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110976256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085059.1">
        <property type="nucleotide sequence ID" value="XM_022229367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XW16"/>
    <dbReference type="GeneID" id="110976256"/>
    <dbReference type="KEGG" id="aplc:110976256"/>
    <dbReference type="OMA" id="QYEGTML"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000683">
        <property type="entry name" value="Abc transporter f family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="72"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="384"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022085059.1"/>
        </source>
    </evidence>
    <sequence length="625" mass="70684" checksum="3A0D5E80747DE752" modified="2022-01-19" version="1">MPKKRAPPNKRRGSAQTDKAGTGKAENGKVTTNGTASNDVNGIIDELDLLDLASDARACTGVLSSHPSSRDLKIDNYSLTFHGVELFQDTRVELTCGRRYGLIGLNGCGKSSFLSSLGNREVPIPDHIDIFHLKREMAASDKTALQCVMEVDELRVRLEKEAEELAQLEGQEVEDTLMEIYERLDEMEADNAEVKAARILHGLGFTHAMMHTKTRDFSGGWRMRISLARALFVKPHLLLLDEPTNHLDLEACVWLEEELKSYQRILVLISHSQDFLNGVCTNIIHMHQGKLNYYSGNYDSYVKTRSELEENQMKKYDWEQEFVDCLQDYIARFGHGSAKLARQAQSKEKTLRKMVEAGLTEKVVEDKTISFYFPDVEKVPPPVIMVQNVSFQYAEDKPLIYKNLEFGLDLDSRIALVGPNGAGKSTLLKLIVGELIPSDGLIRKYSHLRIGRYHQHLQDLLDLDLSALEWMMKNFPDIKEVEKMRRIIGRYGLTGKQQICPIRNLSDGQRCRCIFAWLAFQGPHMLLLDEPTNHLDIETIDALADAINDFDGGLVLVSHDFRLINQVAKEIWVCEKQTVTKWSGDILSYKENLKRNILKEEKSSKKEGGKNGSKAKNGTSKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW29</accession>
    <name>A0A8B7XW29_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fucose-1-phosphate guanylyltransferase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084452.1">
        <property type="nucleotide sequence ID" value="XM_022228760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XW29"/>
    <dbReference type="GeneID" id="110975895"/>
    <dbReference type="KEGG" id="aplc:110975895"/>
    <dbReference type="OrthoDB" id="10062280at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042350">
        <property type="term" value="P:GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="GDP_fucose_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15045">
        <property type="entry name" value="FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15045:SF1">
        <property type="entry name" value="FUCOSE-1-PHOSPHATE GUANYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucose_pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDP-fucose pyrophosphorylase" evidence="3">
        <location>
            <begin position="145"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084452.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="71341" checksum="E6784C86B49AE529" modified="2022-01-19" version="1">MNTLQPHQEPVSENKVILPSGVYMLFWLCFVTTDKARCSEIQPWRRLKQSSAIASELPLSREFKNMSNSKVKKVGDFPFWDIVVISSMDTSQKLAYELQLQEKLDNEELPLGVDYYVIADPGTEKIGGGGSMMASLQCLRETYQKDLETKKVLIMPAGGYSQRLPNASLLGKMFLSIPLGDPFYTMFDLKLALSIDFPAKMSAGVFLGVSDCIELYVDEDSPNWSFDERGVTALGHPSPISIGTGHGVFVVPTRQANSPSVEVVAVEEFLHKPTVEIMQEKGAVLGNDFCSGIGSEEKMVLTDSCYYMDFTTAMKLLELYNDESPLRCEIDCHGDFLQPLGLRATSEYIKNTSNVTKVTDSLMSMRQKVFDVLKGTPLSVAVMQHSRFYHLGTINEYLDHMCNLTPLAKELGLGTHMYKPDGPDDGTCTSGTSRIQASGKCTASACVMNSICPKGFQVEERSLVEYCDFQMPVSIHSNSIVSSCCVGSTPDQKLVTVPKDTFLHTACISDGKAKRQFVTVAFGTQDNLKKEASIEELSMFGKPFKDICGTDLDMASKCLFPDGTTQSLWHAKLFRPADKMEDSFSSTMSLMERVLSESPLQPSLSEWEGCLSMADLIQSKDIFKMLEFRRELRKKMQLSTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWR6</accession>
    <name>A0A8B7XWR6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Torsin-1A-interacting protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110975786</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TOR1AIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084261.1">
        <property type="nucleotide sequence ID" value="XM_022228569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWR6"/>
    <dbReference type="GeneID" id="110975786"/>
    <dbReference type="KEGG" id="aplc:110975786"/>
    <dbReference type="OMA" id="IRSKPLN"/>
    <dbReference type="OrthoDB" id="6258998at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038599">
        <property type="entry name" value="LAP1C-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008662">
        <property type="entry name" value="TOIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046753">
        <property type="entry name" value="TOIP1/2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843:SF7">
        <property type="entry name" value="LAMINA-ASSOCIATED POLYPEPTIDE 1B ISOFORM 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18843">
        <property type="entry name" value="TORSIN-1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05609">
        <property type="entry name" value="LAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Torsin-1A-interacting protein 1/2 AAA+ activator" evidence="12">
        <location>
            <begin position="162"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022084261.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42278" checksum="DCDC7ADCA0A2EC45" modified="2022-01-19" version="1">MPSTTRSQSKKRGMEPSKISAETKNLKGKFKTNDGKKQELPVDETGRKSANQEDGHDEPDRKASHLTDQEQRDASCDQDQTPQKPADQNQGNENNKFSTRMPAESGKYYKVAQIYKQVREIINRRAKNLLLVSVLVLIAAVLVYPYKMYMPGDKPASVRQLEYTQRMQNLKSLFPTQGEHFWDIVEATVNGHLAQGSDPVVPIVLLFGSRPAAADSTKCLTEKLGTLLSETLLAKNTSMALINGKDYRNMDSDVAKEGIDQCLQAAFEGGQKAAVVLSLDALPPCSILLFHSYCENEDARYKDAALIFTVTLKEGHPPSRELIRSKPLNLMGKEAFEISDHLTQVWTDKCHMLPQGKVEAMLSRVANNVATVQKENVVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXE5</accession>
    <name>A0A8B7XXE5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">All trans-polyprenyl-diphosphate synthase PDSS1</fullName>
            <ecNumber evidence="14">2.5.1.91</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">All-trans-decaprenyl-diphosphate synthase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Decaprenyl-diphosphate synthase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solanesyl-diphosphate synthase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Trans-prenyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110976062</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone. Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively. The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>6 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-nonaprenyl diphosphate + 6 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:55364"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58391"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:55365"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>7 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27802"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60721"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.91"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:27803"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterotetramer composed of 2 PDSS1/DPS1 and 2 PDSS2/DLP1 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.91" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022084715.1">
        <property type="nucleotide sequence ID" value="XM_022229023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXE5"/>
    <dbReference type="GeneID" id="110976062"/>
    <dbReference type="KEGG" id="aplc:110976062"/>
    <dbReference type="CTD" id="23590"/>
    <dbReference type="OMA" id="GKQMRPM"/>
    <dbReference type="OrthoDB" id="9927103at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032478">
        <property type="term" value="C:heterotetrameric polyprenyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097269">
        <property type="term" value="F:all-trans-decaprenyl-diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000011">
        <property type="entry name" value="Decaprenyl diphosphate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 20" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00084036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022084715.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="45455" checksum="943A213C1264FF0D" modified="2022-01-19" version="1">MATSLGLRNVGLLRPIVPRLPRSLRPRLNSTTWLLVSEKSNTTCCGCGLPPVVASLATCTKRLLRDVRHFSSHFSTNSNVFPKEICSPEKLTQDDLASLHGNIRKELISNRRSLQDVAQYYFDGKGKAFRPMIVLLTASACNAHTHGANSKLLETQRQIAMIAEMIHTASLMHDDVIDNADTRRNKMAINEMWGQKKAILAGDFVLSVSSQVLARIGNDEVVLILSQVLDDLVRGEFMQLGSKEDENERFSHYLKKTFMKTASLMAHSCQAVAVLGQCHEDVSKIAYEYGRNIGMAFQLIDDVLDFVSSDAEMGKPTSADLKLGLATGPVLFAAEKFPELEAMIMRRFSEPGDVERAKEAVAKTDGIEQTRYIANQHSQEAKRQISRLTPSPARQALIELSQRVVTRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY96</accession>
    <name>A0A8B7XY96_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">A-kinase anchor protein 17A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110976083</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084750.1">
        <property type="nucleotide sequence ID" value="XM_022229058.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084751.1">
        <property type="nucleotide sequence ID" value="XM_022229059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XY96"/>
    <dbReference type="GeneID" id="110976083"/>
    <dbReference type="KEGG" id="aplc:110976083"/>
    <dbReference type="OMA" id="IPACEQN"/>
    <dbReference type="OrthoDB" id="1918237at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd12264">
        <property type="entry name" value="RRM_AKAP17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056852">
        <property type="entry name" value="AK17A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484:SF4">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12484">
        <property type="entry name" value="B-LYMPHOCYTE ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25015">
        <property type="entry name" value="RBD_AKAP-17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022084751.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="63051" checksum="2523A4743B46F70E" modified="2022-01-19" version="1">MTTQLCFNQSEAIELHGPHGLYLKPIAKLNISVTLPQMKMEGKSISNWEVMEKLKRMAKPDSFLVLRVSKSSLEFLRFEAEVEAKSLIKVLILRLDGKVIKLSGFPEPLKVRAAEAKISFPNRHDWDSFFRDAKNMNENNPGERPDTIKIESLPCKWFSSTAEPDKPSELIIKKIFELFGEIRNVDIPMLDPYRHESQVIGGNFRTFSSFNTLTFEAFIQYTEYIGFVKAMDALKGMKLMKKETITDENEKEGKAYTADIKVDFDKTRHLCAKSIQKREKERQRLIQLEKQREEQKRLEREEEERKQEEERRRKEQEELYRIQRKQAKLTRKEERRQQREEKRRQLREEKKRQRQEQELQRRIALEERKLLIALRQLESIRLLTELFERVKVIKQHEEVQRRLEELEQERLRQLEEERLKKEQEERAQEKAAARQQRELRRRELRLKRKLTKNLRNRTEQEEEKRRERLRQRLSGRARLKSAVVPGLYPRPHIDEDRHQYGERVDGERSTKRPKLKSAMAHKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0D4</accession>
    <name>A0A8B7Y0D4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110977104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110977104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086623.1">
        <property type="nucleotide sequence ID" value="XM_022230931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0D4"/>
    <dbReference type="GeneID" id="110977104"/>
    <dbReference type="KEGG" id="aplc:110977104"/>
    <dbReference type="OMA" id="SEKECAS"/>
    <dbReference type="OrthoDB" id="10041690at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032222">
        <property type="term" value="P:regulation of synaptic transmission, cholinergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030431">
        <property type="term" value="P:sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00117">
        <property type="entry name" value="TFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031424">
        <property type="entry name" value="QVR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17064">
        <property type="entry name" value="QVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034796503" evidence="3">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086623.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="13368" checksum="DCF0F5B96AAC066B" modified="2022-01-19" version="1">MKLLAVVICLSWIGSIWGRACYECDQTDAACSDPFKEDNSLKNNCSNTATYCIKTAGEFQGIKAVTRACDDAGTCAQQGSGCLTVDFGGITATQCCCNTDYCNGAGPVRLMSALATASMGFAAMLIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1Q6</accession>
    <name>A0A8B7Y1Q6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">FAST kinase domain-containing protein 2, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4" type="primary">LOC110977367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087104.1">
        <property type="nucleotide sequence ID" value="XM_022231412.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087106.1">
        <property type="nucleotide sequence ID" value="XM_022231414.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087107.1">
        <property type="nucleotide sequence ID" value="XM_022231415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1Q6"/>
    <dbReference type="GeneID" id="110977367"/>
    <dbReference type="KEGG" id="aplc:110977367"/>
    <dbReference type="OMA" id="KSSMMYT"/>
    <dbReference type="OrthoDB" id="9369505at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF1">
        <property type="entry name" value="FAST KINASE DOMAIN-CONTAINING PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022087104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022087107.1"/>
        </source>
    </evidence>
    <sequence length="666" mass="75531" checksum="A3208EBDE0FE864A" modified="2022-01-19" version="1">MLMCCGSVKMLSLCVAKNLEMVKQLLRFVTWNRFLTFESQQYLKLQWLPMMHGRNERVYCTPAWHAPLGYVPEPRKKKVEAKSSDIVSFENLVDGQSLTCLKSIHKACSAPEIFQALRELQGNLNEVHVARAISRLAEIGQKINVAQVEIVGESESRMLAGHQDKDFVDLCYLVLRNVKRMDCNLFLDALKASIDLRVPQSSVMVQTLIASAEQRLNQFNCSDLAKLASVLVRLQETDQRVHALLRAIILLVPDRVGGCTDARALNIILRTVGKQLDHHNRAQMAHRLIAIFSTKKDTDKEKTVMDASKAITEFYFIRYYNGDFLREACNILLDGLEYLPPTRLMKALHSLSGFRFYCPELLEKAGDLIAHLVDKFNFNHLSRILKMYTAQRFLHENLLNAVAISLTKRSLDDESLITLVGMLSPFAKFQHVSTSPGSDACVFGLVAAAAEKQIVGFADRETDFGQLVQLMTLLAMCGAYSEKLMEIIMSRTCNESISRVDRKTLLNLRSLHTIISMKLLKFSSDEQSVRDAHSKELSNILSRFDQDERLTGLKRESKFRTSVAKTLHEEIGTSIATDVAIGNGYTVDFVVSEEMREQRPIAIDLTSAVHFCSNYPDRPLAEGVIKRQYVEAMAYSFRMLRKKDWMALRSTTERAEHMKQVLNFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2Y1</accession>
    <name>A0A8B7Y2Y1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110977250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110977250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086887.1">
        <property type="nucleotide sequence ID" value="XM_022231195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2Y1"/>
    <dbReference type="GeneID" id="110977250"/>
    <dbReference type="KEGG" id="aplc:110977250"/>
    <dbReference type="OMA" id="LMEYVQH"/>
    <dbReference type="OrthoDB" id="6066926at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034116640" evidence="2">
        <location>
            <begin position="21"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086887.1"/>
        </source>
    </evidence>
    <sequence length="647" mass="69529" checksum="9890264F802B51A5" modified="2022-01-19" version="1">MMYQASLVFVLCFLVSTAVAGECPVGCSCRGPDSEFHTAICYNDVLEPAKDFSPAIKTLELRYLPFSSMRRFLKHAPDVTDLIIHDIDGAVDQPVPKNLFHGLKSLKSLTFHTLKEGAVPKGLAGSLDGLDRLRFLDLGRNRLECNCELSHWIGGHDVILLGVRTLSPSTNCREVGFDKDVYNAKELVEMCDKKQEGNLKELADEDVEDAEEEGDEENDDLEESYNDEDYAADEDVEKQESTPESKLSHLKNILRGKKVDQLVVPAAGSPKTDSDESAGKIQPFRWGATAAAGKSPQAPKTSLANKPNSKPSKKPIRQNAVKHSSPTSPLVAAPRPTKIIAAVQSAENPPKSSTSIVADSKATQSTKENAKPMHIAPKHPSTTAPTTASVGSTKGSGMPMSLESLPEILSGVAHSKVSITGGSVKERGTSTPPSATAATTLGVLSTSKSVKTSISIETPGESSTIANVLEESQPDEDTEYAEEDTVDDIAEYFDTTEPTEKTQETSSTTESKILPLFGSEKLASLPIFPKTNQIPETVGNTSAGRASGNDSTGINAGPHAEEAKKILKDFMVLLLKRLAANGVGSPLDELAVDVKLHPNDPFELRLLMEYVQHISGKPAEQQLLTRESVLLPRGQLPSSELDDTIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3W2</accession>
    <name>A0A8B7Y3W2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrator complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110977319</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 12 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087009.1">
        <property type="nucleotide sequence ID" value="XM_022231317.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087010.1">
        <property type="nucleotide sequence ID" value="XM_022231318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3W2"/>
    <dbReference type="GeneID" id="110977319"/>
    <dbReference type="KEGG" id="aplc:110977319"/>
    <dbReference type="OrthoDB" id="5846437at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160232">
        <property type="term" value="C:INTAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160240">
        <property type="term" value="P:RNA polymerase II transcription initiation surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15501">
        <property type="entry name" value="PHD_Int12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000101">
        <property type="entry name" value="Integrator complex subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039054">
        <property type="entry name" value="Int12_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051776">
        <property type="entry name" value="Integrator_subunit_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415:SF2">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13415">
        <property type="entry name" value="NUCLEAR FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022087009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022087010.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="41789" checksum="8FCB91FA825CFC61" modified="2022-01-19" version="1">MAALELDPVFVKALGFLRSRSKDSTEQLKVMLDEALAETGHGRFSKQDSESGKKSGAKQKEEKAPTPCIKLAATEGSRKEAERRAEKRAGEKQLKSDSSDSFDPPSSKRLRSERQRKPVIEDDEDDDDDTEEDNDNEEVEEEEEESLGTEDSSHGDSNPGDSNHGSTDADDFAVEMGLACIVCKQLEVSAGNQLIECQECHSLYHQLCHKPPASEADPNDPRLVWYCSRCTRNMKKQATKKVKNSSSTSHVARESSTKEVEVKADSEVLNIFKRAEPKSTTASTSTGTASKTPYTGLASFAANLTGRSSANSKAAAASSRPPGITGKPGSKVSPVPSPVNKTTPATSAKSQPSTAKAGSGHAGKNLPQASTASAMKRLQQMKKKASSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y412</accession>
    <name>A0A8B7Y412_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 56-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110977794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087924.1">
        <property type="nucleotide sequence ID" value="XM_022232232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y412"/>
    <dbReference type="GeneID" id="110977794"/>
    <dbReference type="KEGG" id="aplc:110977794"/>
    <dbReference type="OMA" id="SIFACKM"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="64"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022087924.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32475" checksum="71E4F5C6991F5F2C" modified="2022-01-19" version="1">MIVTAFQDVMEIVNVTEQRPLEEFSSEYLPALVASFLIFFAMMFFACPRLSAKYVPTYSRLSDFEKADWNTRISSNINAVIVSIVSVYLLVTDDAINADKIWGTSYLARVNICIISGFLLADLVMMLRWFPLGDSWQYIIHHFFVLYPFLNNVVYGALTFFANFRITTECSTLFVNIRWFMTILGHKSSKWYIANGTLMAVVFFLCRIILIPVYYACVYQEVAQAVASLPMRFIIAWLPSGMVMDVLNTYWFRKIYRGAKKALWGQSKPKGPPPIRNRVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4N2</accession>
    <name>A0A8B7Y4N2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110977568</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 11">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087497.1">
        <property type="nucleotide sequence ID" value="XM_022231805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4N2"/>
    <dbReference type="GeneID" id="110977568"/>
    <dbReference type="OMA" id="MIMGWMM"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000007">
        <property type="entry name" value="Glutamate dehydrogenase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000100">
        <property type="entry name" value="Glutamate dehydrogenase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF13">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="246"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="10">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022087497.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="59565" checksum="295F9906630F2574" modified="2022-01-19" version="1">MLRILASSVQREGAKALTLSGLSRASGSAVNTRRNVCSAAEEEDPNFFDMVEEYFDRGAALVEDTLVDNMKGSMSKDQKRLKVQGILKLMKPCNNVLSLNFPLRRDDGRFEMIEAYRAQHSQHRTPCKGGIRYSSDVNADEVKALASLMTYKCAVVDVPFGGAKGGIKVDPKQYSERELEKITRRFCVELAKKGFIGPGVDVPAPDMGTGEREMSWIADTYAMTVGYQDINAHACITGKPITQGGIHGRISATGRGIYHGIENFVNEASYMSTVGLTPGFGDKTFIIQGFGNVGLHTMRYLHRFGARCIGIMEIDGSIYNYNGIDPKDLEDYKLQHGTVVGFPDAEPFDGDLLVEQCDILVPCAGEKQITSRNAPHIKARIIAEGANGPTTPAADKILQERNIMVIPDLYINAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNQFLLESVQESLERKFGKHGGRIPIVPSEKFSDRISGASEKDIVHSGLAYTMERSARQIMRTGMKYNLGLDLRTAAYVNSLEKIYNTTLRAGLAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4U0</accession>
    <name>A0A8B7Y4U0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977233</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B. Inhibits TNF-induced NFKB1 activation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COMM domain-containing protein 6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086866.1">
        <property type="nucleotide sequence ID" value="XM_022231174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4U0"/>
    <dbReference type="GeneID" id="110977233"/>
    <dbReference type="KEGG" id="aplc:110977233"/>
    <dbReference type="OMA" id="TISQFQN"/>
    <dbReference type="OrthoDB" id="10251827at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF5">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="4">
        <location>
            <begin position="135"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00039908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022086866.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="22502" checksum="91E035124E309126" modified="2022-01-19" version="1">MMRHAVFQTVPEGFFNAVELLNQLPSDLLTELCHQVIAFLQCSKGLVSATQFLEKLHEANVHSCEQAVLGAINALTFLFRSAAREKVSADDLVKELKQSLVWSDTCQDIVKEVWIEKGQSLSSSEVVHRVLSVGQLVDMQWKLGVAMTSGICRSLNSTFVMMTLKIADPSGKVTTKSLEMTVAEFKNFSKQMREMAAMLEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4W1</accession>
    <name>A0A8B7Y4W1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gamma-butyrobetaine dioxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110977489</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087370.1">
        <property type="nucleotide sequence ID" value="XM_022231678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4W1"/>
    <dbReference type="GeneID" id="110977489"/>
    <dbReference type="KEGG" id="aplc:110977489"/>
    <dbReference type="OMA" id="MAFFHCI"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
        <property type="entry name" value="GAMMA-BUTYROBETAINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="11">
        <location>
            <begin position="100"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="199"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022087370.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="55165" checksum="DDAE479C358A4215" modified="2022-01-19" version="1">MFWSGVRQVLRPTLPGLLPRTWSPASVTSRNVRGFSAVFTRDTLPRVGVSPSNSKAIPVSVTTTRLPKGQPLAATPVVARCYVSQDIQPNIQIGSLSKDDTRRIVSVTWSDGKRREYPFPWLLDNCLCSDCYHVESQGRLLPFDQLDITAHPESVESINGGDTLRVSWNRRHHSDFDSHWLRSVKFDQKPPDDVALTTPTLWGAEITESLPRFEFRDVVSDDQALFDFLKAFYEFGIVKIEKTPAEPRQIPIIAKRIGPMRETSFGLLQPLKKGGNQVEELDPDRALSYTTKALQLHTDMSCLYETTYMAFFHCIKSSNCKGGDSIYADGFRAAEMLRREDPDAFQMLTTNQQEFRLVGAEPHVGDFDHRCFHFPIKLDHFGRLKAVHYSTHARTTAMFMPVDDVQPMYNALQVFAKLLESPENAYYVKLQGGEMIVVNNHRVLHGRTPFKDSGERHLELGYVDWDHVTSRMRVLQRKLSDDKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7Z2</accession>
    <name>A0A8B7Y7Z2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exportin-5-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110978199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088682.1">
        <property type="nucleotide sequence ID" value="XM_022232990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7Z2"/>
    <dbReference type="GeneID" id="110978199"/>
    <dbReference type="KEGG" id="aplc:110978199"/>
    <dbReference type="CTD" id="57510"/>
    <dbReference type="OrthoDB" id="2215036at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042565">
        <property type="term" value="C:RNA nuclear export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045478">
        <property type="entry name" value="Exportin-5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF3">
        <property type="entry name" value="EXPORTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19273">
        <property type="entry name" value="Exportin-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="2">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022088682.1"/>
        </source>
    </evidence>
    <sequence length="1222" mass="138699" checksum="33617A54E1833CA8" modified="2022-01-19" version="1">MLSLPHKYSYCFSLTSPHHRPRLRFAPFPLCRPCLSVTVTSRFKKWSRADFQKRHLCEEFKTSAPYSLCIACGQLLASVSNSTVVRHFGLQLLENCVKFRWISSSPSEKLSLKEFVLSYFHNGTHHLLEEQMCIKDGLSRIMVEMIKREWPQNWPSLMSELNTLCSLGDTQTELVLLVLLRLVEDVVTFQSLQTSRRRDVLQALTSHMAELSTFMIQLLKHHVQTYRQLHSNSSGSETQLASSIRVSQAVLLTLTGYVDWIAPQHIFADNNALPSMLYSLLTIQELKLAAVEVLQLIVNRKGKPEERHPLLVLFSADAIKTILAAAQNACAAGLDEENYIFLKRLCHVLTGLGAQLCILWGSGIKDIGRPERFQDFLEALMAFLGHPSMHLCSMIVPLLSAFFRHDQISRDESLLGLVPQILQILIAKLQKVGYPSREDSPTCTYSRLDYDSDEEFSYSFAIHRTHQTELVRLITDHCPLLAFQAACDWLREVIVSPITVEPGRDACTQHSPSYIHWDALTCFLENVLGRLFQSDGLSKLTPQLAQLLQMTLAFQTEDPTLLSCVLSTVSTLFPVVKEKQELVNTFLDKMFSAAVFSLPGQTKKTRTRPVQNVRRHACSALVKICRDNSEFMVHFFDQLYGRIKLLNEDQDQLTQLEKSTLNEVLILLSNKFKHLEKQSALIQEIMEPVRIVWMADPMKEVLGNEERFLEHIGLCKTLPCSLDDKQGANRATILACLATMMAVMKRTKWSHNSQEVLGDDVSASCSSAIVYHDPCFLFVLPLLDNVLALMRTMNGMWSPESRARIPVEFSKVFDIPDNDKTAVLGLTQPSSDNYELPANRSTTEKIQGFLSTAQEHCCHVLASACDNMGHKLYASRPFTEHLVQSMALLLNHAPDNRLRPVIRVFMKSLVLHCPADCHGDVLLPVLHYLGDFMLQRLTCAWDVVNKRIDMGEDSETRESNQESQEIIDEMFLRLITRDYLDLLSSVFKKKNGGTDASEGYIMEEMMESDSVTSEEVGHKMTESEQLGELGKMILQDESLCKSMVVCVYSSLSWNDTQTCVKSLNICWPILQQIVEKPITLGAAKYLFTCLLLGLQVHGQHDTCLALLVQKTFQHYESLRPRFDVLQEVMLQIPGVTQEALQTFDRRFIFKEDHKKLTSEKSRRDNFKKLIGGIIGRHIGQMFKREIIITDLRPVGKPVKHKNTSDEPERTDIGLVALFAHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8G0</accession>
    <name>A0A8B7Y8G0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter AVT1I-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110978169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088640.1">
        <property type="nucleotide sequence ID" value="XM_022232948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8G0"/>
    <dbReference type="GeneID" id="110978169"/>
    <dbReference type="KEGG" id="aplc:110978169"/>
    <dbReference type="OMA" id="WWIMASS"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="41"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022088640.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="50279" checksum="76C7BFB028FAB082" modified="2022-01-19" version="1">MVDSTNRQTLRLLDKSQNVSERSLSGADTKEFEDELDTANGINIWQTAISLSGVCAGLGFLAVDVLVVSTGWIGFFLFILLYAALLYTSIILGRCWNMVRDKWGHERHPYGAIGYEAFGGLARSLINILVAAVCFSNAIVVLMGFSEMTLTIGGAALEGTLCYWPLAYGLVICPFFWLATPKSFWWIMASSFFTVVMSVILVITSVFVAGSPTSSGINATEEVPRESAFFHLTEIAGTVFWLMAQHGCIPTLQQDMQQPQGFSKAIILADLMTLFLTLPVMLALVITYGNTLTNVSGSAIVYSLLPEDALKKVSASLIMVHLTGAVLLVNNPLFQYLEEVLHIPIEFSWKRVVLRSSVLLMQIFVQETVPHFTLLSSISGGFLTPLISFLVPCLFYLRLRKTYQPEPTKWSMLETIACVVIIAATPCIIVAILFGTGTAIASGRTAFTVPCYVNATLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8R7</accession>
    <name>A0A8B7Y8R7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Structural maintenance of chromosomes flexible hinge domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088750.1">
        <property type="nucleotide sequence ID" value="XM_022233058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978240"/>
    <dbReference type="KEGG" id="aplc:110978240"/>
    <dbReference type="OMA" id="PIECFNR"/>
    <dbReference type="OrthoDB" id="10009947at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058611">
        <property type="entry name" value="Ig_SMCHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058612">
        <property type="entry name" value="Ig_SMCHD1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058613">
        <property type="entry name" value="Ig_SMCHD1_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058614">
        <property type="entry name" value="Ig_SMCHD1_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058615">
        <property type="entry name" value="Ig_SMCHD1_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058617">
        <property type="entry name" value="Ig_SMCHD1_7th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058616">
        <property type="entry name" value="Ig_SMCHD1_8th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038892">
        <property type="entry name" value="SMCHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055109">
        <property type="entry name" value="SMCHD1_S5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22640">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES FLEXIBLE HINGE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22640:SF2">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES FLEXIBLE HINGE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26194">
        <property type="entry name" value="Ig_SMCHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26195">
        <property type="entry name" value="Ig_SMCHD1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26196">
        <property type="entry name" value="Ig_SMCHD1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26197">
        <property type="entry name" value="Ig_SMCHD1_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26198">
        <property type="entry name" value="Ig_SMCHD1_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26201">
        <property type="entry name" value="Ig_SMCHD1_7th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26199">
        <property type="entry name" value="Ig_SMCHD1_8th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22899">
        <property type="entry name" value="SMCHD1_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="1720"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1924"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1957"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1649"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1991"/>
            <end position="2025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022088750.1"/>
        </source>
    </evidence>
    <sequence length="2025" mass="227660" checksum="F09D2A745126305B" modified="2022-01-19" version="1">MAANSKKQVVGAANATKALDEEDSVVFVYDRRKGNEPERKIDIGGVFNFPTFKERIRQEFNISNNIHFVIATTNREEIKDNGGYEELIDSGDTLYILNHINQNLPAPAKERVEFLPHYDTLVKSGMYEYYASAGQNPLPFAFAELIDNSLTATCDNLGPRTIELRLFLDESGDKSMICIIDNGKGMTSRQLNNWAIYRLSKFIRKERRPKQTDDDDNRSNSPANEAVPRSLTSDISYFGVGGKQAIFFIGQGTRMITKPKDSRDVHELTISKEEFERREKNRESIYSGFISNRPVGDARHLGSDDQNLKNLIKEEIGKESFTHVIITGINSHHIHYLKHDFVGWCRQLAHIYHYYIHGPRGNEASGLGNKRPISPFKNIDITVEIHERGKTPRVISLRDIKDDMQTKYIRSAIDSFEFRAVVEGTGIVEGILRYHPFLYDKETFPAVDSIPGVDGDVIEEEDYYNEDRPARGNRPIFECYWSGRLIPYTCVENFDWCSAPKKRGPIPVECYNRISGVLWTNDKFEVSTNKLTFIDLEVRLKDKNTIFQKIVLGQAQRVKIDRQFHEWLRECHETYDKQVKFCSFEGAIARPEIAVKRQQSPWAVYKAIEWDGKIFKRGQLVRTFRTVPIITGTIKRFLLYGHHEGDVFATGGEMEIAQEPKLLYDEVKVVPLSKLDRSANDRILKRFIEEEEGKLPEKLIVTWPEGNQVKQGDRMAAGSTVGAIQVDIKNRKGESISRLPGSHLAAKKLLVELKVILHTPNGEEELVSHLSQYVKAWSYWFKRMENMKNLGDHTIKIQVVLNESGVTAFGGRPLPNHKIKFSITEAPPSKFSVGLLDPPFRVGVPFNIPLELQDEFNHSTKPVPNMKPVLEASGLELSYAGVQARGTTLLVKDVTAIGDVGSFQGKNFNFKVTLPGLAFPTQTLKIRLSPGQPHSLHVPTFVEEISIENGQALNVTIEVRDKAGNITVHPKLDVTCKFLGAPGLPTYCGDCSTGKTTLTGNIIFFKNLKKGQKITAKVWLPNFSDISPIEKVIQVLPNSNPHYIDMWYTENSGSTKLRHQQELRWPAGDHIKGILFALFDEGFRQIKISPEIASKVKVSWMPRLSHEKVQQGILPDIKVPASAAEAKYVQLSLSDGSGLEFGFTIRPEPGEVSQIKCVCQGSKKVRLGEVLDGDIIVNVTDSHGNPIKKVPHGALSHLEVTGEGLKTKQLQKFIIPNTGFALRQVRFEGGPLGQRELCVKYHDFTEYVKLQMLAGPPTKLSFIDTSLYEPVSVFSGSRIDKNLTVQLCDENDNPTSDTNARMTLTGSSGLDNVNLQMKADKDGRAGFGRPIISAATGHHKLTIKAIVGRNVLVSTVDIYIQPDPNKPTAVFVEFEKIPSLIVGDFFPAFDVRVEAEDGSVFLKLPPKNVLMRLWKVDTSSQTKPSPEAVSYVPDNRQQDDKPGHFYFRKRKAPEVAGHYNMFFQVMIGHQDTIISETLSFVVHPGPPVKLVPDSHQPMVTVSNTQKSLSRSLVRTLKLQLKDQYGNATGSNVSGKVVVSLCGDGGNELPMLVGNKSSAEFSMTKGVVTVQNLVLQESTPGKDGGEYSLKVEVQSPQLKPTNVDPYVQPFLFYNDARKQYRMSQLTKERDTLLQTINVFQGFFQTTDKLIAEMKMSVQEAQHNENQIKSELRKLLIQTSQVNTVETIQRLLSEAQRQRETMLQLPRRKCELSMYVDMNSNPAILGKIGQLAEVVDDTIAHVLSWHMLTDMDCLVVRTSEAAMKVYQATQGRQQVLPLDSIFRKSIPNWNRELPHTRFLRTYQPPGNPVFARHLLQFPAHEESCRLVFGQLLGDVIILDTLEDATAYRREIVNVTPCPTLLTRDGNRVKSNGKFGGTHNQFLPLEKMKGVIFGAPIPEACHQLSKQIELLESLLQATQKRLEVEQELTVQEEEQKSASMRNKRRECQEAVEQLALVEKKLGMNQSSAEGDVGPERSGRLTPQQQQQGKRVRSSSRSPVSSVTEESSPSTRSRRTPVSGSTGSTKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAX6</accession>
    <name>A0A8B7YAX6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110979143 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110979143</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090394.1">
        <property type="nucleotide sequence ID" value="XM_022234702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAX6"/>
    <dbReference type="GeneID" id="110979143"/>
    <dbReference type="KEGG" id="aplc:110979143"/>
    <dbReference type="OrthoDB" id="5989160at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038877">
        <property type="entry name" value="THSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311">
        <property type="entry name" value="THROMBOSPONDIN TYPE I DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16311:SF3">
        <property type="entry name" value="THROMBOSPONDIN TYPE-1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034697275" evidence="5">
        <location>
            <begin position="29"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="137"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022090394.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="50882" checksum="8496D6EA9BF49987" modified="2022-01-19" version="1">MMAPKIHLHEVYWLVILHCLSIYRPACGQNGEGDEYGSFDSNAGRPGQQFGEDIPYNVPSSYSRNKPNMEVADAGASYEMNAPIAKNPVGTSGFNPVVDGSWGQWSEWQFCSVTCGQGAKVRDRLCNQPPPSNGGQPCMGKNVESGKCQASQICGGSTTLQEVVVMAGWSVVLNCFADWYIQQHPTASVEWYRNDQPVDATAGNRQLVNMADLQLGFVTAADEGIYACAFQQAGHTVYMTAIVLKVNQIVQHILDEDQIQLVAIFWPIGLPVLLLCAVLCSMRGEVKRYKRKGMPPEVMEEIKQRKLENKRKKEEAKREAKLQKKEKKKSPPAAQAATESAPPPPEPGGGAPPPPPPSGPAPPPPPGSSAAPPPPGPGPSAPPGPGPPPPPGPMAPSMPPPGPPTAMAPGPPAPQHEMIPTPMAMMMKQGPPTIGAPPPAGPPMGPPMAPPTGPPMAPPGPSGPPPPPGGGGGGTPGPPPPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAZ7</accession>
    <name>A0A8B7YAZ7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC110979145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110979145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090398.1">
        <property type="nucleotide sequence ID" value="XM_022234706.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090399.1">
        <property type="nucleotide sequence ID" value="XM_022234707.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979145"/>
    <dbReference type="KEGG" id="aplc:110979145"/>
    <dbReference type="OMA" id="QRRKAQW"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056564">
        <property type="entry name" value="Ig-like_KY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053041">
        <property type="entry name" value="Transglut-like_Superfamily_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47020:SF1">
        <property type="entry name" value="HILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23265">
        <property type="entry name" value="Ig-like_KY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="3">
        <location>
            <begin position="931"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="556"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022090399.1"/>
        </source>
    </evidence>
    <sequence length="1419" mass="162554" checksum="6DF5ACE690D949B3" modified="2022-01-19" version="1">MGSGTSKSGGKGKVMVAAEVVVPGQSKPVKVKGQVNLKNNEGVSGQLPGPATVKQVASNKFSLQMGSQSLGTFDVTQGDSDFASHLSNAAQMTVTNIEMIAEDDEANSNEHLGQSFQIQLSQDTSFSNNQYSDDEDWEEVIEDLDAKENQPTSSEGAKERKARLKQALQEKRTHLSQQEYEQMIANHKQEVELMAMLREKERERQKYTLASKVAQRQQRRKARLDEKKELEKLSKEKTIDEGKEEVEASHQVNATTFINGATDDVEKSAQQIEKEIQQRNAAFEQEMKVKRERLPEAEYQRLVAQHKAEMEKLKQKLERETDRQKQSLADKLEERRRRKNLGGGQYEEPEMSPEEIQQLEADLKRRQIQLEAMLQDKKSQLSPEEYKKLIAEHREELNKLQHRLDLQRERQRQSLLDKLAARKALRDRRGNAEVSEPLSADEVKDLQLALNQKAMDFKKQLKDAKGTLSPDETQRLIDEHRREMDALQEQLDAEKERMRRVLIDKLEARRRSGKGEPDEEASPLTAEEIKQLQLALDLNDTKFKEDMKAKKTKMSGEEYQRLMEQHKKEQEELAAMLAAERKRMEGKLQEKLGARRFRPLTAKEPNAAKSEEILKLEQEILQKESTFANEVTKKKSEMSEAEYQRLLAQHERDMERLKGRLAMAVERQKRNFSDKLSARQRRKAQWKAEEEERMRLMARLEDSDACNTEEDLSNLQQDISRYDNDIRSNIQDRKGKVSESEYKRMIEEHDKNMWILQSKLDKERERMRQVLEAKRMARGQKATGEAVVATQRAETQEELYNSDEEADEFGGNDTDAIAVPTEVTQLWTTPTQSTSLVVVPLKEEYPVKKKRELYTNPDIFRRLDAHAIKLAQTVSLVTQPTFSALVNELVSIGGTELEKVRLICRWITAQNCDEMDLNDIIDDTPLGVLKGLYHKKITFSTLFMRMCRFVGLRCVEINGCAKNKAYNPGQYITSNDPTYQHTWNAVRIDGYWHFVDCNWGVSHIQGSVAFDPFRFEYDEHYFLADPDVIIRSHFPNDPAWQLLNQPLSLQDFNASVPLKPDFFKFGFVLLSHTSAVIGCPNGELDIRVQCPLGLILSTRLATLQGRREFSRAGVPYDQFDFIHQVAENAMACYIRIPDPGDFYLTLYAKRQYLDGEINLETETEICRYLVHNSAPCGDQVPLPSSPADHWGPIGVMNVGLTPLTHRTAVVMTHDASDIEVRFRLMRNELSFTHTLTSWGWKPEDLVVYSMQRVVGEELVLLVTPPKVSRYGLHILAQYPGMPTPVHVCSYLLVCTTVKQVMAIPLLSRGEHWGPTEACTSLGMSAFTHPDPFVVTSDHSIQIVMGLSSSMIAAHELIYYGQRDPHNATSEVSPEFEGQSVTYVLPLRGPGYYRFTIKGKECDDPSLPLTQLFHYLIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE53</accession>
    <name>A0A8B7YE53_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acylneuraminate-9-phosphatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110979302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022090675.1">
        <property type="nucleotide sequence ID" value="XM_022234983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE53"/>
    <dbReference type="GeneID" id="110979302"/>
    <dbReference type="KEGG" id="aplc:110979302"/>
    <dbReference type="CTD" id="140838"/>
    <dbReference type="OMA" id="TYHNVKF"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050124">
        <property type="term" value="F:N-acylneuraminate-9-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046380">
        <property type="term" value="P:N-acetylneuraminate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.710">
        <property type="entry name" value="Haloacid dehalogenase hydrolase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051400">
        <property type="entry name" value="HAD-like_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470">
        <property type="entry name" value="N-ACYLNEURAMINATE-9-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470:SF3">
        <property type="entry name" value="N-ACYLNEURAMINATE-9-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090675.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27670" checksum="70927E072C7F7F34" modified="2022-01-19" version="1">MAAAGKVSAIIFDLDNTLIDTRNADFFAFKQVKAVLRSQFAEVDADDVVAAFRKYLAEAEKDPNEVIPVDEWRTELWQRALNSHHPKDAAVLLYRTWMSGRLDHMTFSEEVKGLLRRLRQRYKLLLMTNGPSAIQRLKMARCGADEYFNGIIVSGEQPHPKPDVSIFRTAFEMLDVPAEHCIMVGDCLSTDIQGGLDAGCLATVWIDPKEQNKEIFFPSPNYSIASVMEIDKVLDDINTSVAAGTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YG94</accession>
    <name>A0A8B7YG94_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022092263.1">
        <property type="nucleotide sequence ID" value="XM_022236571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YG94"/>
    <dbReference type="GeneID" id="110980174"/>
    <dbReference type="KEGG" id="aplc:110980174"/>
    <dbReference type="CTD" id="340481"/>
    <dbReference type="OMA" id="WLFNTLF"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="127"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022092263.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="31358" checksum="B150DE7662C07388" modified="2022-01-19" version="1">MVNFTFQDLQRLSGDSEAYSEMQAQAEYIQTSPKIIFLPCRLQFVRNVKGYFYLGFIVFTWAYNTYIVPKLVLLPQYNEANISMLPVLCYYAVSLFTVVALFRSATSDPGRLPFDLKPTTSDQLNWTHCQRCLIQRPLKSHHCSKCQRCIRKMDHHCHWINNCVAEDNQWIFILLVFYAVLLSLYTLVLDTLHFYYFPACKTCNSNRSTVESIIHAHKPIHERPAVIPRSAYDGFRDVCGPGPVLWWFNPFRRRSVKPEIYYYQHTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGA1</accession>
    <name>A0A8B7YGA1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-related C3 botulinum toxin substrate 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979701</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091425.1">
        <property type="nucleotide sequence ID" value="XM_022235733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGA1"/>
    <dbReference type="GeneID" id="110979701"/>
    <dbReference type="KEGG" id="aplc:110979701"/>
    <dbReference type="OMA" id="NPEVTHH"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022091425.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="21401" checksum="651366F705BF5039" modified="2022-01-19" version="1">MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPINLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLMSPASFENVRAKWNPEVTHHCPNTPIILVGTKLDLRDDKEAIEKLKEKRLSPITYTQGLQMCKEINAVKFLECSALTQKGLKTVFDEAIRAVLCPPKQVKKKKGCNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGJ2</accession>
    <name>A0A8B7YGJ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110980216 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092358.1">
        <property type="nucleotide sequence ID" value="XM_022236666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGJ2"/>
    <dbReference type="GeneID" id="110980216"/>
    <dbReference type="KEGG" id="aplc:110980216"/>
    <dbReference type="OrthoDB" id="10063453at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034356230" evidence="2">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022092358.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21699" checksum="03009D693DC8F1F5" modified="2022-01-19" version="1">MQSHLVLLFLALLAAVCAEVQLEETVIPDGPEEVPVQDEENDQTEAPTAEDTAQVLEELEHQIFDQVVRADEVAPNPRAKTTRRCCKLGRQVAQNGLFCNLDLLQVQKRPNVVHRRKMKFHGPEVHGKTVYKDLMRRVEKCALSNASESMFVKCCEWQRDIIHDLEQCKLLDTLSERRRCRRRVQARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGR4</accession>
    <name>A0A8B7YGR4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium and integrin-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110980242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092433.1">
        <property type="nucleotide sequence ID" value="XM_022236741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGR4"/>
    <dbReference type="GeneID" id="110980242"/>
    <dbReference type="KEGG" id="aplc:110980242"/>
    <dbReference type="OMA" id="HAHQKFK"/>
    <dbReference type="OrthoDB" id="114727at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000035">
        <property type="entry name" value="Calcium and integrin-binding family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051433">
        <property type="entry name" value="CIBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791:SF1">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45791">
        <property type="entry name" value="CALCIUM AND INTEGRIN BINDING FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="99"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092433.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21140" checksum="2F1C86FCC29048A4" modified="2022-01-19" version="1">MGGSHSVFTEAELDDYQELTFFSKKEILHVHKRFHLLDPDAVRADKNARLPMSTILELPELKENPFKDRICKVFSSADDGSLQFEDFLDMMSVFSDAAPKSVKAEYAFQIYDFDDDDFISSTDLREVVNRLTGEQHLSDADMQQLIDNVLEESDLDDDDALSFAEFEHVISKSPDFINSFRIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHW1</accession>
    <name>A0A8B7YHW1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110980457</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1&lt;-&gt;1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
            <dbReference type="ChEBI" id="CHEBI:189081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70248"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>UDP-alpha-D-xylose + an N-acylsphing-4-enine = a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:70244"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022092844.1">
        <property type="nucleotide sequence ID" value="XM_022237152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHW1"/>
    <dbReference type="GeneID" id="110980457"/>
    <dbReference type="KEGG" id="aplc:110980457"/>
    <dbReference type="OMA" id="ECAFLNT"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02520">
        <property type="entry name" value="Glucosylceramide_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000041">
        <property type="entry name" value="UDP-glucose ceramide glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022092844.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="45623" checksum="164E28EDF6143710" modified="2022-01-19" version="1">MDYLYSCVFGLACFFVCLEIVCLYLFHFMAIIYIKLTLHKRPVYGLNGTLPGVSILKPLVGIEENLEGNLETFFTLDYPKFELLFGVHTPKDPARKVVESLMKRYPHVDAKLFVGGMSDWGKIRNPKVNNMMPGYMVSRYDLILISDSGIKMHYPNTLTQMVHEMKPDVGFVHGLPFCCNREGFGGTLDKAYFGGSHARLYLSMNMLGITCVTGMFNLVRRSVISAAGGFEELAKYISEDCYMGRATVKSGFKIKLSTLPAMQNPGDWDTRAFDKRMVRWTTVRRSTIPSTIILEPISEMLVCGLCCAWAVHYLFDWNPLLFIVLHILQWFLLDCIQLYMLQTEPFSVSKLEFVLAWIYREFTTPYFFLKGCLEDKVTWRTGKFQVTWGGFIEKVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YI75</accession>
    <name>A0A8B7YI75_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110980503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110980503</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092949.1">
        <property type="nucleotide sequence ID" value="XM_022237257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YI75"/>
    <dbReference type="GeneID" id="110980503"/>
    <dbReference type="KEGG" id="aplc:110980503"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="699"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="804"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="886"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022092949.1"/>
        </source>
    </evidence>
    <sequence length="956" mass="107919" checksum="7F20951322A2325D" modified="2022-01-19" version="1">MAMEKQAVIKETHHRSVTAIGYHPMRREILAGFEDGVIKTWEAEGSKLVLTTYEHQGWVTDFLYWHDGKVMFSSSNDGMIVAWASGGGVYDRIKIGSPIYCMALNQRRHQLVCGLNGYIRVYGLDEKREKSSIVQVDSPYISKEHTDIVKCIVCLESRVYSAGFDSKLIIYDSSSYPGNKGLTPVFCNPKAHDAGISCLVLIKDTENNTWLVTGSFDKVVKIWSQDGKLTHRLDGFLSTITDLCYVPKNKTLWIASGLPTATLYDPKSGENVTDFIGTFQEEEDNQKYHLHILKYIPEMGEHTIFLLNGSFSKSNSHLCTKMSDPSFSLDEVRQHPLTKRGSPLLSSAFIWFIVTRPCGAFIQCFVYRAQVSHRYRHVYVLTHPGNFSRNTELMNRATRLQVILSVPGRLDKRGIHTASPPHNNPIIHSQLKTNINGSGHQLCLHSHVSPVDQIRNFVFVHTYTYASMYRFFNIFISIAASTSRRHLMMWKYNPSGCITALKCKHAVECLTYTHKVPILIFDGGSDGQANKWERLQSNHFMYSKETFLLAEAKNKLTQVMNLKKDPHQQVQVSSVVRVVKPQLGSHYIFNKPEAQPAEHQKHYHPALLKATFAEDLDLLLLGSEDGNIYVWGFDDAAVNALRDMKPVGMPELVKKYAVLLREDSELLGENGLYQTGLMDSQAQDSVTNRVAGFICKNVLIGHSSCVTCLTLIGRDSGFGTTYMLSSGWDRRICIWDLETGTLHDTFRNTSRDSYEVQELACDGIVIDMDYSCQRKEFAYASSDKMVYIRSFDPDGSKMRLSNTLQGHEGEITQVKWSRARSNWVTASEDGTIRIWSGDGMSCIQVLATHGAITSLCIDAYNSCIIAGVQNTIKVYDPDNYKLVQTNVGHTDSIRSILHLPERNQYVSGSWDGSLRVWNAFKPIARKKRLKIEEKRESIAGFSANNPNYLIEDDDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YME7</accession>
    <name>A0A8B7YME7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110980884</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093625.1">
        <property type="nucleotide sequence ID" value="XM_022237933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YME7"/>
    <dbReference type="GeneID" id="110980884"/>
    <dbReference type="KEGG" id="aplc:110980884"/>
    <dbReference type="OMA" id="IFIVEET"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF165">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093625.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="25121" checksum="F9FAC87EFDDECB4F" modified="2022-01-19" version="1">MHPAAPIQTVQIQVASPQSPRHSRYSCSVKSLGILQIVLAVVSAALGIASAVIWRHYSLASIVSGAWGGLVFYLPAGILGILSVRVSTSRRRVAIATMVMSILAAVMAGTNIIIYSICMTQTVYYYNPYYYISAELGLNSVLLVVSLAELVVSIVASAYCCYVMKEYQPATTTIQYGHPTTNNIYNHQPAAYPGPAVAQAPAMFVTNQAAASSPPPSYGNAVGADIDDTTKGNINLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMG6</accession>
    <name>A0A8B7YMG6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110981293 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094454.1">
        <property type="nucleotide sequence ID" value="XM_022238762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMG6"/>
    <dbReference type="GeneID" id="110981293"/>
    <dbReference type="KEGG" id="aplc:110981293"/>
    <dbReference type="OrthoDB" id="159229at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053257">
        <property type="entry name" value="Cu-only_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910">
        <property type="entry name" value="AGAP001623-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20910:SF1">
        <property type="entry name" value="SUPEROXIDE DISMUTASE COPPER_ZINC BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034805013" evidence="2">
        <location>
            <begin position="43"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="3">
        <location>
            <begin position="349"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="3">
        <location>
            <begin position="525"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="3">
        <location>
            <begin position="662"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022094454.1"/>
        </source>
    </evidence>
    <sequence length="1071" mass="115839" checksum="3CAFBA7D76AA2A1A" modified="2022-01-19" version="1">MPRGVASGGSLMSKRPRPSETHRVFCRLLLAVYISFLHGTSAEMNQTNLHVASFSMRGVSGKVTFFEAEAASGQAMVMINVALIGLELGNYTWAIHEKPMVYGQEPACSEELVGPVYTHAGDLTGALNATTTVTESGSWNASYSSALVSLTGPQSITGRTLVLQEALSQAAYCAQIANARALVTAVARFDAPFAGTVTLRQESGNPEADTTILVDLYDVTDPIEQMTYAWRVSSNSGYNQDVDLETRCKETSSNTYNPTGVDVITCRPEDPLNCPIGYLSGKFNNVTVTPVPSAVTHYFIDTNLPLSGENSVVSKSLVFSDASGDPVACSPILEMKPKSSEAIISVNNVSGMVRFRQSSPYDVTEIKVHLENLRGLAGGFHVHVLPPVPRTYASDQPAGPQNVAGHFNPYGIGAAPPPGTGTNDQYEVGDLSGKFGLLTGYDNFNATFLDWNLPLFGRHSIIGRSLVIHKKEGDRWVYAAIPYPTKKKTVKAVFKAPSVGKIVMSQDINDPYADTSIYVEMAYADGTDTTTGHNWHIHTKAVANDYISKDRRCSSCAGHFNPFDADLGPSYGQCSPAFPQRCELGDLSKKHGQLTITNHMNLGMGKFFFTETSLPLSGVNSVSGRSIVIHASDGGSPRISCADLLEVPPTVTTADLWSDGPVSGHITFQQESIFDPVQIHVDVKGLSNVAGGWHVHVLPIDKDMDSAPCSPVSVLGHFNPFGVVGSPPYGTQDMYEMGDLSGKFGSFYGYVDSADHVYHDTNLALEGPRSIIGRSLVVHKSADGSRWVCATLHRKTHPDDFIVTAKAVVTATDYTGYAILSQTRYHTGALGDTTVEFGVLSNVAEMDTFYWNFRPVEPEDDACTGSSSIFNPHKVSVNRDYGSQCDAKTQLRCAVGDMTGKHGNVSSIVKRTVYTDVNLPLSGQDSVLGLSLHLISTNTGQFTCGTLEPDASTGRVEYLSYPRSTSFDPYKFRQALHDYMTGAEMWQIVTTQEPEVNQVTGCATLKFYFIGAGLDDMDREFKQKVQADGLGEYSPTSQCRDISGGGIQTMPAALPMFFVLLANCFILFLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMS1</accession>
    <name>A0A8B7YMS1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase/reductase SDR family member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094563.1">
        <property type="nucleotide sequence ID" value="XM_022238871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMS1"/>
    <dbReference type="GeneID" id="110981357"/>
    <dbReference type="KEGG" id="aplc:110981357"/>
    <dbReference type="OMA" id="EFHSCDV"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005559">
        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE (SDR FAMILY) MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43943:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022094563.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="30878" checksum="D823D4F5C37A19F9" modified="2022-01-19" version="1">MSLASHHLWAFLRSGFLTKLAPGGQYQSLAVRMASAAACKRLVGKVAIVTASTDGIGFAIAKRLGSEGAHVVISSRKQDNVDRAIKELKDENLSVTGMVCHVGKAEHRAKLINETVAKHGGIDILVSNAAVNPAFGPMLNTTEEQWDKIFDVNVKSTFLLIKECVPHMVDRKGSSIVIVSSVGGYNPFSLLGCYSISKTTLLGMTRALASECGPMGIRVNCIAPGIIKTRFSEALWSDKSVLDLSLLTATIKRPGESDECAGAVAFLCSDDASYITGENILITGGMHARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN17</accession>
    <name>A0A8B7YN17_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Muscarinic acetylcholine receptor M3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110980474</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092865.1">
        <property type="nucleotide sequence ID" value="XM_022237173.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092866.1">
        <property type="nucleotide sequence ID" value="XM_022237174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN17"/>
    <dbReference type="GeneID" id="110980474"/>
    <dbReference type="KEGG" id="aplc:110980474"/>
    <dbReference type="OMA" id="ICDIWLF"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007197">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15049">
        <property type="entry name" value="7tmA_mAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247">
        <property type="entry name" value="5-HYDROXYTRYPTAMINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24247:SF265">
        <property type="entry name" value="MUSCARINIC ACETYLCHOLINE RECEPTOR DM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="54"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022092865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022092866.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="51106" checksum="70381236C74765B4" modified="2022-01-19" version="1">MELTVTVETMDAPMNCTGVNCTDEPDEGLSNLEIIKIICMAILSAIASLITICGNALVIVAFCRERRLRCLSNYFIISMASADVIIGAFSMPLYTMYLLIDHWPLGPVICDIWLFVDYLCCGASVLGILLISVDRYRCLSHPMTYRSDMTRARVLFLIIASWITTILLFGVPIVGWQFFEGKRTVPANQCEVQFTNDAFFTAGSIIMIYWLPLVVILILYIRIYLLTRHLVKREARIIGRLSVRHHVEPAETSHNNNHHDRKFSSGVMLDSEDEQTVSFPTRDLPLPPHPEEDNDVCGRASCSTHYNNGCRVDGERRVTLPSETDEFSESDRTTQASHRTSTKASPNSKDHTIGKTLSAALNSLKEAKAVRTLSAILGIFIVCWTPYSVLVIVKGFCPDCVNTYLYELSYFLCYINSTCNPMCYAFANRDFKIAFKKILLCDGQKYGWKANHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNM1</accession>
    <name>A0A8B7YNM1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">F-box/LRR-repeat protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110981552</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094863.1">
        <property type="nucleotide sequence ID" value="XM_022239171.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094864.1">
        <property type="nucleotide sequence ID" value="XM_022239172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNM1"/>
    <dbReference type="GeneID" id="110981552"/>
    <dbReference type="KEGG" id="aplc:110981552"/>
    <dbReference type="CTD" id="26233"/>
    <dbReference type="OMA" id="WHEAASQ"/>
    <dbReference type="OrthoDB" id="3134645at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22119">
        <property type="entry name" value="F-box_FBXL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047922">
        <property type="entry name" value="FBXL6_F-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="160"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022094863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022094864.1"/>
        </source>
    </evidence>
    <sequence length="581" mass="64422" checksum="57C5F506DC9C65D7" modified="2022-01-19" version="1">MARHQRLRQRGIFGLLKPAEPMFFSFLPNGAQEWPSDDDDADSDYSPGGAVHYDDEDEQEACSSKLQTLPKNTKPKTGPLKGRVNSGKRQDAEDTKRQRQSAVKSSSKSARPKKKTRRETRASLAASSSTETQEMGSTDELDTYSPAGSSSEGHQMWGQRLPMIVLQRVFQFVVQAEGAIPYLCRACQVCRLWREAAIHSSLWQHMDLANGRIKCVDTTLQWLAENRLSHLKSINLGGWSKLTDIGLKALVTHCSKYLTSIYLNGCIKLTATSVCLLVDNCPMLHTIDLSHTNADVVSITSMTHILQTTSGHLRLLNLSGNRLKRAPIILKCLKTHCSNLVTLNISNCKFTSDFLMLHIEELQRGCPRLEVLHLAGCMVRASQVSSKVQAESTGFPQLQELSLSVNTNVVNGGIAIDDNMLFRLLVKSHQLKLLDLRGCTHITAVGMQRLPVYDLQHLFISQCSVSRYEGIEAIIHKWRHSLIELDLSWNVFPAMALDIAMKKLSSVPGQSVLRVINLAGTSITAERVRSILEGCPSLVSLHLASCRGLPRGMKRSYHGDCLVQLKSDLNAAPASSLEYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNV5</accession>
    <name>A0A8B7YNV5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein TSSC1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110980600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIPR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093136.1">
        <property type="nucleotide sequence ID" value="XM_022237444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNV5"/>
    <dbReference type="GeneID" id="110980600"/>
    <dbReference type="KEGG" id="aplc:110980600"/>
    <dbReference type="CTD" id="7260"/>
    <dbReference type="OMA" id="HQFLALH"/>
    <dbReference type="OrthoDB" id="196957at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060341">
        <property type="term" value="P:regulation of cellular localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051049">
        <property type="term" value="P:regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000156">
        <property type="entry name" value="protein TSSC1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="WD40_rpt"/>
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    <dbReference type="PANTHER" id="PTHR14205:SF15">
        <property type="entry name" value="EARP AND GARP COMPLEX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14205">
        <property type="entry name" value="WD-REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23609">
        <property type="entry name" value="Beta-prop_EIPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="EIPR1-like beta-propeller" evidence="6">
        <location>
            <begin position="7"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="226"/>
            <end position="268"/>
        </location>
    </feature>
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        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022093136.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="43809" checksum="33C79ADF05B931C6" modified="2022-01-19" version="1">MEDDAPVIYGLEFQARALTAQAAESEVIRFLVGTQSLKNENQVHLLEFDDDNNILNKMVFLHKDGEIWHIGSNPADKNILTTCYNKITDNKVSTCAALWRIPSDADPADQDPEIQDDSTTYARPLEVLCRFDNSDIGNVISVLWEPQGNGSKALSVSDNHLTKWDLEASDSEAKVSSSVALESKGHPKFTAGRWNPHHNNTQAATANDTTIRGWDLRTMKQCYTIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDVRKTESPVLTLTDHSHWVWSVRYNQFHDQLVLSSSSDSRVILTNATSISSEPFGHLDEDDDDSEKEEDAETKPKEPIKDGLIANYEEHEDSVYAAEWSTVDPWLFASLSYDGRLVINRVPKAEKYKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRE1</accession>
    <name>A0A8B7YRE1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING finger and transmembrane domain-containing protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982027</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095849.1">
        <property type="nucleotide sequence ID" value="XM_022240157.1"/>
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    <dbReference type="OrthoDB" id="9049620at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of ERAD pathway"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="RNFT1/2"/>
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        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860:SF0">
        <property type="entry name" value="LP20373P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860">
        <property type="entry name" value="UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C3HC4"/>
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        <property type="entry name" value="RING"/>
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        <property type="entry name" value="RING/U-box"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="50"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="184"/>
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            <end position="259"/>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022095849.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="32615" checksum="DB82435B891D1D1E" modified="2022-01-19" version="1">MSGNGRVVLNLNPLLEVYSVTVLFIGMQAAFSIFNCIVKKQVSCWDERNLRSVIATFLLLCLIVYSVHRFFFGHLILQSLSFTTYSFDELSLWTVFVVVYAIGITDYVISYVAMATKCVVIALPRACLSFERRGRFFQFIESLYQLYQFLIPLPLWISFVSDSTGLYWFIGGVLGSLYVIWKLFETYHKLCKCKAFFKSILQHSPYGSRPSYERMQEEQTCPICLDNFSNPVEIPCMHIFCEECVTRWFDTGKNTCPICMARVAYSREWRDGSTSNNFPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YS48</accession>
    <name>A0A8B7YS48_ACAPL</name>
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        <submittedName>
            <fullName evidence="8">TBC1 domain family member 2B-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="8" type="primary">LOC110981178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094216.1">
        <property type="nucleotide sequence ID" value="XM_022238524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YS48"/>
    <dbReference type="GeneID" id="110981178"/>
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    <dbReference type="OrthoDB" id="294251at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative TBC1 domain family member 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000248">
        <property type="entry name" value="TBC1 domain family member 2A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
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        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TBC_RABGAP"/>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="122"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="771"/>
            <end position="965"/>
        </location>
    </feature>
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        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="476"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1063"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022094216.1"/>
        </source>
    </evidence>
    <sequence length="1082" mass="123099" checksum="287C346773392168" modified="2022-01-19" version="1">MAVPYSLGNVMDGRLERRKLHDDTAPTSEVPTAVLISFDDEPSLEGTTGNVADQTASAMQEYDSDRATESMQLDTAVDGPSSRALAGPGPGGGGQVVNGADGDKVTLEASKIDSQKRGTMEEVKLCGYLNKMGEKGLIKTFKTRWFVFDNQRCRLYYYRTPQDLLPLGSIDIANASFNFEASDSTGTGHFHISTGGRVYQLQAKDRHTMMFWLQELQERRRAYSHQRTSLQRDKSLGHVSPTSLQPKTGLVSTQKIKDRSGDPFRGLPPILGPVELPTHSVGESTAHTMQQTGMFNLSLTNLKTEIRNQMSSLGLRRNASDEAPLVNLASETSQTDPPKAVKRPSSLNTAPSSGNQEPGQSESLPPADQGTRKAYESFKAGFIKKFGRTSSADIPSPTAVWFENESVQDYECAQCRKFHSQLNAVQEELELVENEVKASQEVITMLHKQLTATQMEHSTNDIFLQSKTDKEKLLILNRKDKQLIQLEQLLQEMREDRDRVVEQLRSKEREVDHLNEQISMFMELITAKDQVVMSLTSRVHELEQNEPIRLTTKPQGTLQHRPLSGPQGRGSGSFTERTTDIPFIDQAAFDKLKDACQAFETQNKFLNTEILELNKIREDDLLRERMMFEKHSELEAEFYRTQSKYLLLLDQLKTPKRGSDLVNETDDELISRLIEEAIESDTNDQTQPSTQAVVNERYDRYGFIQEMEENGEEASKLASKAAVAQRRSEEIESQRSDRGISLSIKWENYLVQHGDGELTKTLELKFLVRQGIPHEYRHRVWKAMVEWHVKKDKELTGPGYYDKLIKSEKFKMNPATKQIELDLLRTLPTNKNFDNIDSKGIPSLRRVLKAYSVHNPTIGYCQGLNRVAAISLLFLDEEDAFWCLVAIVECIMPADYYSKTLIGSQTDQRVFKDLLTEKLPRLSTHLDNFGIDLSLISFNWFITVFCDNVPPETMLRIWGTLLYEGNKVLFRFALAFFKMSEAQLLVLHDYIHIFNYLRKMTSKMTDISRLTQIAFDELSHFPRRHINNRRAVHRAQIKQQLEELDKMRDEYVPQHRPSTEGVISDDDEDYDTVEALGGNSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTW5</accession>
    <name>A0A8B7YTW5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pancreatic lipase-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110982076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095915.1">
        <property type="nucleotide sequence ID" value="XM_022240223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTW5"/>
    <dbReference type="GeneID" id="110982076"/>
    <dbReference type="KEGG" id="aplc:110982076"/>
    <dbReference type="OMA" id="PFCGHEY"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF178">
        <property type="entry name" value="LIPASE MEMBER H-A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034402762" evidence="5">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095915.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="37985" checksum="19FC9DC0186E430C" modified="2022-01-19" version="1">MGIAANILVLALGLFLASANDAVNPDNVCTGSFSPVTYPEVGTFDANLWCHRRGFPPMHPNQIGTKFRLYTRKNPSSPTVISTSSLGYPFSASSPTKFIIHGFTDKGETSWLLKMKDKLLAKGDFNVIGVDWQKGASPSFIPDYCKARQNIRVVARQIRNLIKKMQSKYSAFSLNNVHIIGHSLGGQMAGYVGQEFGGKIGRISGMDPAEPDFQGDQTGCRLDPSDAKFVDASHCSMFGIFQPVGHVDVYPNYGTHMPGCASWPELSEGTCGHSKAIDYFTDSISNDCGALAYPCTWQTGQGQGCKYSGQSGVSGVKFGYRADQTPSSKYGLYIMMTNQNSPFCNPNSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YV78</accession>
    <name>A0A8B7YV78_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Filamin-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095231.1">
        <property type="nucleotide sequence ID" value="XM_022239539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YV78"/>
    <dbReference type="GeneID" id="110981725"/>
    <dbReference type="KEGG" id="aplc:110981725"/>
    <dbReference type="OMA" id="PNESHAQ"/>
    <dbReference type="OrthoDB" id="18740at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000006">
        <property type="entry name" value="Filamin-B isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044801">
        <property type="entry name" value="Filamin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537:SF8">
        <property type="entry name" value="FILAMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38537">
        <property type="entry name" value="JITTERBUG, ISOFORM N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="83"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="201"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="305"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022095231.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="45920" checksum="62D45C8FF692218C" modified="2022-01-19" version="1">MYAPKDINKAKWLGRDACSARRNIFLLRSTRGTRTGVHLKFFVSRANPTPELELSDPTSTLVDDPTAVMPDSDPTAADAEWKKIQQNTFTRWINEQLKPAGKYVYNVETDLGDGLILIALLDQLIASDGRSPDLPRCNKRPVFKSQRLENISIVLKKIEDEQIRLVNIDASDILKGNLKLILGLIWTLILKYQISLDSSSKTPKQAMLEWINTVLPDRCITNFTTDWNDGIALSALINFCDPTLLTNVKSLDPASALDNCTHAIQLAKDKFEIPQILDPADMNNPKVDELSVMTYLSYFPRKGGPGWKTTLNWVRNKVPELNVQNFQSDWNDGRVLCALAEAVAEGACPEWRELNKDEKLANCQKGIEAGTKLGIKPTLSAQQLMSHDVKEHDVLFYAVHFQLFELKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVJ6</accession>
    <name>A0A8B7YVJ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Disheveled-associated activator of morphogenesis 1-A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10 11 12 13 14 15 16" type="primary">LOC110982891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097339.1">
        <property type="nucleotide sequence ID" value="XM_022241647.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097340.1">
        <property type="nucleotide sequence ID" value="XM_022241648.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097341.1">
        <property type="nucleotide sequence ID" value="XM_022241649.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097342.1">
        <property type="nucleotide sequence ID" value="XM_022241650.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097343.1">
        <property type="nucleotide sequence ID" value="XM_022241651.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097344.1">
        <property type="nucleotide sequence ID" value="XM_022241652.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097345.1">
        <property type="nucleotide sequence ID" value="XM_022241653.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097346.1">
        <property type="nucleotide sequence ID" value="XM_022241654.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097348.1">
        <property type="nucleotide sequence ID" value="XM_022241656.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097349.1">
        <property type="nucleotide sequence ID" value="XM_022241657.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097350.1">
        <property type="nucleotide sequence ID" value="XM_022241658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVJ6"/>
    <dbReference type="GeneID" id="110982891"/>
    <dbReference type="KEGG" id="aplc:110982891"/>
    <dbReference type="OMA" id="AMLYFQE"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000800">
        <property type="entry name" value="Disheveled-associated activator of morphogenesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="3">
        <location>
            <begin position="40"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="4">
        <location>
            <begin position="602"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1071"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022097339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022097340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022097341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022097342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022097343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022097345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022097346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022097348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022097349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022097350.1"/>
        </source>
    </evidence>
    <sequence length="1096" mass="123658" checksum="7D42AF99C12566FB" modified="2022-01-19" version="1">MPRKRGGGLLCGCFGGGDETPHITYDVDNGMVLHPMEVADPMPPLEELNLMFVELVDELDLPALHRERMFSLSPEKKWQIYCSKKKEQDDPNSTKWPDYYLDQLKAMMTLAFTHDEDVIAARTNLVDSLKTALRTQPMRFVMRFIELDGLSVLLEFLENMDFDLMESPIHTSVIGCIKALMNNSHGRADVLAHPTAINIVTQSMSSENIKTKIQVLEILGGVCLVPGGHRKVLTAMSHYQEYASERTRFQRLVNDLDRSTGHYREEVNLKTAILSFINAIIKYGAGEDNLEFRIHLRYEFLMLGIQPVIDKLRSLENATVDRHLDFFELVRNEDERELAKRFNMVHVDVRSANSMFEVIKKKIAHTQAYPHFLSLLQHFLLLPNKGSSIHHWSLVDRLVQQIVLQYEDGGDPDVAPFDINFKDVIEKVINQDVIRQQKAEELEKSYEELKAQLERKERELDAKNQEKRSDAPCALSPLPVVTTMEEAMSALNSIQERFDQQAAELAMSSRQGQELQAQMAELKAMIASGKLGAVSLSDDDMLKVDSLKSPASLSGQPAPPPPPAAPFAPPPPPGMGPPAPPPPPGQGGPPPPPGMGGMMAKKKNYPKPSNPLKSFNWAKLPDLQLQGTIWTELDGMKILKIMDLTEFDKVFSAYQKVDTDGETGFSFKSSKRKELSVIDGRRAQNCTILLSKLKLTNEEITKAVLSMDQGEDIPKDMLEQLLKYVPTPEEVALVKEHERELDSVARADRFLYEMGKINHYEQRLKCLYFKKKFQERMGECKPKVEAVLKASKELSSSKRLRKVLEIILAFGNYMNRGPRGNASGFRISSLNKILDTKSSLSKHPTLLHYLTAVLEKKFPDVFKLEEELASLRDASKVNMGELDKDINIIGAGLKEVEKELDFQKNRPSTEKGDKFVSVMSDFKTVSSISFSKIRDLQAQAKEKITKCIKQFGEDPAKMTAEEFFSTFDAFVQSFIEAKIDNENMRKKQEEEEKRARIEAERVARERKRKASKKENQNGRKQGGEGEFDDLISALRTGDMFGEDVAKMKRNRKRQSQPAQPAAANGSNGRPKMGEVSRERVGKPKPATTPSSKMTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW30</accession>
    <name>A0A8B7YW30_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CCR4-NOT transcription complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CCR4-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110982641</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT3. Interacts with NCOR1, NCOR2. HDAC3 and GPS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096902.1">
        <property type="nucleotide sequence ID" value="XM_022241210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW30"/>
    <dbReference type="GeneID" id="110982641"/>
    <dbReference type="KEGG" id="aplc:110982641"/>
    <dbReference type="CTD" id="4848"/>
    <dbReference type="OMA" id="DYHDESL"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000001">
        <property type="entry name" value="Putative CCR4-NOT transcription complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="17">
        <location>
            <begin position="427"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="95"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022096902.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="63247" checksum="4EFE3984E1853815" modified="2022-01-19" version="1">MSNAPYVLDAGSGMSQESRKSQPDLSLGDFGLLSSNIKVRSKMNFYKDGAENDLGENSAYFPQSTMFPSHRSEKDLLTSQSQSLSQYGIYGNQGYGLQQQQQPSGPPRGMPNPQQQQPQQQLPFPSRSMSGHHGSIGGQITPTPPSPSRGMLPVGPRVSQVQTSTNQPSMSAPSRVGTLGSGMPSPNSRTSPSLLAMQQKQQQQRMLGGSTQSAIGAFGMTRQQSYGGPQNALLGNFTPQSLAASFNSVNESSPSLDMAEFPVLANRGRQQPPPQQHDNNSLSLFPPNPMAGRPAYVGMVNKQADPVPEFTMQSEDFPALPGSNIISKSSSEQNSTGVVKESPRYPGDKTANNNSNNDNQQKRGIQIHPDGKITHIPPGIVTDPFGIVGLLTFIRAAETDPNLVQLALGSDLTTLGLNLNSPENLYGTFQSPWAESPSRPQDIDFHVPQEYITNMHIRDKLAPIKLSRYGEDLLFYLYYTHGGDVLQLAAAAELYNRDWRYHKEERVWITRGPMMEPQVKTSLYERGLYYYFDHQRWCKVAKEFHLDYDKLEERPHLPASFHHNVSTNPVMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYC1</accession>
    <name>A0A8B7YYC1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycerol-3-phosphate transporter 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110983074</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097687.1">
        <property type="nucleotide sequence ID" value="XM_022241995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYC1"/>
    <dbReference type="GeneID" id="110983074"/>
    <dbReference type="KEGG" id="aplc:110983074"/>
    <dbReference type="OMA" id="GMFYLMI"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF30">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097687.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="46225" checksum="72BAB36266CD255D" modified="2022-01-19" version="1">MQLKYHQACIFALTWMAYAGTYLLRKPLAVVKTDLSNELSMTKTELGWLDTAMLFPYATVQIVFGSSADKYGPRRTLAVCLLISALSMASFGSWQSFYVYAILLFINGAAQSQAWPSCVKGLGVWYTTQHRNAIFGIWGTCTFAGGVLGTALAVHLQTHHGWRQAFLIPSLLLSGLGLLVLLFLHTPSDYQVTIPGKDLESSTSEKPALATPSFVSLWNLPMLKEVAVSMFCVKIVRYCVFMWLPMYLHQQLHYGKTESGMLPTSFEIGGVIGSASLGCLIQRLLRGQLLLGSGLAILASTLSLVCFLLTASWGAVFNVTLMLIAGAFNCGVDPILSGSVPSEIGEMDGRRIQASVSGFVNGFGSLGTVLQGPMVGAITEYYGWSGMLYLIITLSLLGCIASLKGYLISTRLRQRSTTRKHEMCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYQ1</accession>
    <name>A0A8B7YYQ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110982344</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096366.1">
        <property type="nucleotide sequence ID" value="XM_022240674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYQ1"/>
    <dbReference type="GeneID" id="110982344"/>
    <dbReference type="KEGG" id="aplc:110982344"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096366.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12633" checksum="2F302A3301147815" modified="2022-01-19" version="1">MGRSDVHEQGRRRTLRTRATIKLEEEVHEEKMMEQGVANEWAASVESTEPESGLKRDSSSSHGEDPSDSHSDSDEEQEQWMEKTASRKAVTCQSYLSSVKKSLFAGRFGPGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ91</accession>
    <name>A0A8B7YZ91_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Major facilitator superfamily domain-containing protein 7-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110982447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096526.1">
        <property type="nucleotide sequence ID" value="XM_022240834.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096527.1">
        <property type="nucleotide sequence ID" value="XM_022240835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZ91"/>
    <dbReference type="GeneID" id="110982447"/>
    <dbReference type="KEGG" id="aplc:110982447"/>
    <dbReference type="OMA" id="STICWTG"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17399">
        <property type="entry name" value="MFS_MFSD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="60"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022096526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022096527.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="54700" checksum="C6742A12FBB6F488" modified="2022-01-19" version="1">MDEEKLLPDVLESPVPLNPQPLNSAKYIMSSTSSTITTTQSVPAQHSSRTYKVYKRRWYMLSVLAVLNLSNAIGWITFAPVADLTASYYNTSYTNVNWLSIVYMVASIPVGFLSTWILDTFGLRVGMMMGAWLNVVGLGVRYISTIEQVQGDIKFIVVMIGQGLAAMAQPFILFAPTKLAALWFPESQRAIANTLGSSSNPLGILASFLLSKIIVQKEDDIPTMLWIYIIPGGVAAAMMTFGFCSSVPPTPPSASAAESSESFLQGLKKILNNRAYLLLLLVFGSGLGLFNCVSSLVEQILCSRGYDDSYSSLVGALMIGGGMLGAIVTGVYVDKTKKFETTAKLCFTTAVLGLIAFCTLSCFREVSVSIAVAGGVFGTAGFGAYPVIMELGVETTFPVAEGTSTGFLVMAGQVQGIIGIVLSNHLGRNLSPVQQDFSQCKGSVTAQDLTIPLLIYAGYGAFNACIFLLFFRTEYRRLKAEERHAADSILNFSSHSHGTPVSSQGNLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0D2</accession>
    <name>A0A8B7Z0D2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Coenzyme Q-binding protein COQ10 homolog B, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110983803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099059.1">
        <property type="nucleotide sequence ID" value="XM_022243367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0D2"/>
    <dbReference type="GeneID" id="110983803"/>
    <dbReference type="KEGG" id="aplc:110983803"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000002">
        <property type="entry name" value="Coenzyme Q-binding protein COQ10 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="10">
        <location>
            <begin position="78"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022099059.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26950" checksum="64ADCA7FAE6989D1" modified="2022-01-19" version="1">MFSVLCLNLRPFKRSLQIFCRSRHVCVSIMIPHQHQRSLLKERCLNRTQVLPQLREAPSRSFLSILDKRKEYSERIIVGYSMEDMYEVVSSVENYKEFVPWCIRSSIRSRKAGHFKADLEIGFPPLVERYTSTVTVVKPHLVKSVCTDGKLFNHLYTTWRFGPGIPYKPHTCTIDFSVSFEFRSALHSNLSTLFFDEVVKNMVKAFEKRAEKLYGPQTAIPRSDQLRYTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0I9</accession>
    <name>A0A8B7Z0I9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Gamma-aminobutyric acid receptor-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110982658</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096936.1">
        <property type="nucleotide sequence ID" value="XM_022241244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0I9"/>
    <dbReference type="GeneID" id="110982658"/>
    <dbReference type="KEGG" id="aplc:110982658"/>
    <dbReference type="CTD" id="11337"/>
    <dbReference type="OMA" id="AVYQEHK"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17232">
        <property type="entry name" value="Ubl_ATG8_GABARAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000037">
        <property type="entry name" value="Gamma-aminobutyric acid receptor-associated protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022096936.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14193" checksum="8AAE6E78D119E59E" modified="2022-01-19" version="1">MTMKWVYKEEHPFEKRRQEGEKIRRKYPDRVPVIVEKAAKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIQLRPEDALFFFVNNVIPPTSATMGQLYQDHHEEDFFLYIAYSDESVYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1L3</accession>
    <name>A0A8B7Z1L3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM124A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM124 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098665.1">
        <property type="nucleotide sequence ID" value="XM_022242973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1L3"/>
    <dbReference type="GeneID" id="110983606"/>
    <dbReference type="KEGG" id="aplc:110983606"/>
    <dbReference type="CTD" id="79843"/>
    <dbReference type="OMA" id="FTIHTHI"/>
    <dbReference type="OrthoDB" id="10023686at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029380">
        <property type="entry name" value="FAM124"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046365">
        <property type="entry name" value="FAM124_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14715:SF6">
        <property type="entry name" value="FAM124 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14715">
        <property type="entry name" value="FAM124 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15067">
        <property type="entry name" value="FAM124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM124" evidence="2">
        <location>
            <begin position="139"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022098665.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="49341" checksum="206EFC883236128A" modified="2022-01-19" version="1">MSQPRSVSTIIHGVSTAELRLADGARRFSLLRTWTRPAMSASQMMGSPSTPPPPTLLAPPPGFAVNQSLAPSKPTKLQRRKAVSTKSKMALLNIKWVPIDPAPAYEMMSPGHSNGSTGSYPSGDYSSDVGLLKDPYALTLHFVTDPGGATKTKNLIKPLVKWFDPSFKLFNIAERSKPNGFRGNLIERDVFPALSVVLFLSHADDDGESENRIIEAQGYLARKPWRYHHHAHTPSRVYLCEPNNLNFYTTEQEMPLWGIRQVHYGKEHLRFMLYTGRDTWHDMIRFYCLLLGRDVEYQKNDFCYFIVHEASCNMDVQFALKIVPDDCSCKPLNSAFLQFKVLEIGDLVPLLPNSCSPISPQRWQTTDPDGNVTLLLVAKRSVNNNLPRVKPRRHSIDALQTLLAPKALKPRLDGARLRMGVTSPGLPAVDDDEEEEDMSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1Q7</accession>
    <name>A0A8B7Z1Q7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099538.1">
        <property type="nucleotide sequence ID" value="XM_022243846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1Q7"/>
    <dbReference type="GeneID" id="110984052"/>
    <dbReference type="KEGG" id="aplc:110984052"/>
    <dbReference type="OMA" id="YSWPKPA"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF48">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022099538.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36781" checksum="07AF8B6D67C7BD92" modified="2022-01-19" version="1">MEVWPLALGLLFVVLVVVTTILFTDRLFVNITGKYVLITGCDSGFGNLLARRLGEKRGCHVIAACLTEAGRTALDSVTSSNVTTIFMDIRNSDSIQRARDRVKSIIPRGEGLWGLVNNAGIISALGLPHWHTRQEVTNVMEVNLLGTIDVTNTFFPLVREARGRVVNVSSGVALFPTAGSYYAVSKAGVEAYSDFIRASMQLSGVSVHIIEPGSFKSSFVNPQTTKDLLKKLWYRLPLEERQDFGGEKAYKALELTMSQALEMASSDLHLVTDAMEHALSARFPWRRYLPGLEAKLFYKVFSLLPAFFTDFVFALGLNFLLKRNMKTSNSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4V6</accession>
    <name>A0A8B7Z4V6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ataxin-2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100668.1">
        <property type="nucleotide sequence ID" value="XM_022244976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4V6"/>
    <dbReference type="GeneID" id="110984618"/>
    <dbReference type="KEGG" id="aplc:110984618"/>
    <dbReference type="OMA" id="CTRHYES"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034427384" evidence="2">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100668.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="40272" checksum="697BC2B746A6C61D" modified="2022-01-19" version="1">MIMSILASIDAGLMLIPSIWGAAIEESDPSCTRHYESYFSYFYCDVAWEARLAVDAVIAVVALAEMVFAIVGSACSCYGLSKDIPNSAPDTEMQVRYVPQQQQQQATQFVPVINTQQQQQHQPLQLQAVPGPTAVPGGYLVSSPHIGQGLAPTQHLGLASQQATLPQQHSGRSTPLLSVSQQHSGRSTPQMVYTPQLVGAAVAGPPRPISMSAQPQAAAKTEEADRQQSGVPVQHACRRVAQQIGVDYQQEGSSSQQSGGALQPVGMGPGQVQMGTQQAGVGSTRVVMVAPQVGMGSPLVGIGAPQLGVPPQDMAPQPQGLPRVQPDIVAEGRDPQPATFPASDKKERDDADQEFDELEMAMGGDEQYDDDKQLLIETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6T3</accession>
    <name>A0A8B7Z6T3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984987</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101353.1">
        <property type="nucleotide sequence ID" value="XM_022245661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6T3"/>
    <dbReference type="GeneID" id="110984987"/>
    <dbReference type="KEGG" id="aplc:110984987"/>
    <dbReference type="OMA" id="IVCWGGV"/>
    <dbReference type="OrthoDB" id="5959603at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034381599" evidence="1">
        <location>
            <begin position="21"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022101353.1"/>
        </source>
    </evidence>
    <sequence length="307" mass="33007" checksum="6AB77C3622025E47" modified="2022-01-19" version="1">MKHSKMILLSVGLLFSVAWAIPVSDSSAPPPPPIIVPVVTNYITTEVQTLAQDASITFIGQLCEQYKGMGVQVTVLLNNNPDWDPSVGVLYYYVVDDPNKGSSAALCNNSPGGSPQANCTVKAWPSNGDIYIKGHAGQSEAISFTLSVVIRPKASKGGASIKPRPFSFIKPPLRNLGGTPSANNLTVYLSEVVTLTATQPLGYHKKALLAFTFCPTPQTGTRYEVQSTTSATDGRSSYASYICDKLPCVVDGENVIAHNGRQLPSNIVRTGSGTWKTLYALIVCWGGVWNPPKDEYIGHFIFNAHIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z784</accession>
    <name>A0A8B7Z784_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA (Adenine(37)-N6)-methyltransferase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110984706</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100827.1">
        <property type="nucleotide sequence ID" value="XM_022245135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z784"/>
    <dbReference type="GeneID" id="110984706"/>
    <dbReference type="KEGG" id="aplc:110984706"/>
    <dbReference type="CTD" id="51531"/>
    <dbReference type="OrthoDB" id="4882at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.70:FF:000014">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2310.10:FF:000002">
        <property type="entry name" value="tRNA methyltransferase O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.10">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023368">
        <property type="entry name" value="UPF0066_cons_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818:SF0">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01318">
        <property type="entry name" value="TSAA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="4">
        <location>
            <begin position="62"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022100827.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="47446" checksum="3C3B3017BCAEF06E" modified="2022-01-19" version="1">MPMRQVKWIRGLLDISAKICQKNNVTYFPKIMNFMASTQSGSASQMDCKAEAKEAELMKLSGSPIGFIQSCFKSKNGTPRQPSVCAFSRAKLRVLKEVFPNPEHSIQGLAEFSHVWILFIFHKNGDRKFTKAKVKPPRLDGDKVGVFATRSPHRPNPIGLTLAKLDRIEGNTLHLSGVDIIDGTPVLDIKPYVPSYDNPDRIHHHQTPSLNPCHVLDFTDLGPSDPMLRDNRDTSDAACSVNEKKVSRENLVSVLNQKSTCHPNDTLLRSQSRATESKVTLDSHAQRHASDLQHVETAGGSLLGERSDECSQSSQVGVADWINSPPITSLEVRFTTHAETELEKFQKDSSDPSYCLELLLDQQEAKQAICNILEADPRSTYRRNNCKDRLYFFTVDTLHITCWFGVNFVEVVRIQPVKFADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7B1</accession>
    <name>A0A8B7Z7B1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Casein kinase I isoform alpha</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110985091</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022101533.1">
        <property type="nucleotide sequence ID" value="XM_022245841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7B1"/>
    <dbReference type="GeneID" id="110985091"/>
    <dbReference type="KEGG" id="aplc:110985091"/>
    <dbReference type="OMA" id="IMTQPLH"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000120">
        <property type="entry name" value="Casein kinase I isoform alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022101533.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38685" checksum="51E140F84FC44DED" modified="2022-01-19" version="1">MACTSGSTTKSEFIVGGKYRLVRKIGSGSFGDIYLGINISNGDEVAVKLESHKARHPQLLYESKLYKILQGGIGIPKISWYGTEKDYNVLVMDLLGPSLEDLFNFCSRKFTMKTVLMLADQMISRIEFVHGKNFIHRDIKPDNFLMGIGKHCNQLFIIDFGLAKKYRDSRSKSHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLSKGFPAEFSMYLNYARGLRFDEGPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKVAAPPSHPSTANHMTAQGTRHSESRNMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9I0</accession>
    <name>A0A8B7Z9I0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110985128</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101617.1">
        <property type="nucleotide sequence ID" value="XM_022245925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9I0"/>
    <dbReference type="GeneID" id="110985128"/>
    <dbReference type="KEGG" id="aplc:110985128"/>
    <dbReference type="OMA" id="TEWAKFS"/>
    <dbReference type="OrthoDB" id="10029673at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="7"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="111"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022101617.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="42870" checksum="53B5195E41CD0C45" modified="2022-01-19" version="1">MSETWVQSGSGLHRAITDQRIRQVRLLVGLGMDVDKRDSAGRTPIMVACSLDSEELSLKVIRLCLKKGADINRVDSAGRSVLSHACMHGREAIVAFLLEEDSLEKNLPDQNGDTPLNLAAARGELGCLELLVRSLTKDGIPVDYRNKQGCTALLLATKGGHYRCAQVLLQQGRSSVNSRDNECFMNPTEWARHSQKLLERDLQQRTRAHQSSLGAASTGASLLGNHHRVAKPFLPPIGIKKWYEEEELLTRQRQIQESMNALVQSLEEREKELRDQGADNQKPPPTAKPSSFASTVVFPDGPTKDHYLCALFRLYQDQLLQRPTRLTSRPTTVPGAGTDPSTDGHLGAGDTRRLSVISANPKRPLLRRQMSTLAIGGFMKTKLTLTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAN7</accession>
    <name>A0A8B7ZAN7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PiggyBac transposable element-derived protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100311.1">
        <property type="nucleotide sequence ID" value="XM_022244619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAN7"/>
    <dbReference type="GeneID" id="110984418"/>
    <dbReference type="KEGG" id="aplc:110984418"/>
    <dbReference type="OMA" id="IYIWWHT"/>
    <dbReference type="OrthoDB" id="5985989at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029526">
        <property type="entry name" value="PGBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272">
        <property type="entry name" value="DDE_TNP_1_7 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47272:SF1">
        <property type="entry name" value="PIGGYBAC TRANSPOSABLE ELEMENT-DERIVED PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13843">
        <property type="entry name" value="DDE_Tnp_1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="PiggyBac transposable element-derived protein" evidence="2">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100311.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="46973" checksum="C5351B3D5B641C33" modified="2022-01-19" version="1">MLDDVVEYSNQYSAQKSGHVANLSRKELEQVIGMFYRMSLLQMAGVRAYWENETNHEPVSGVMSRNRFQYLLTVLHFVDNLAMTDEDKKADKLWKIRPWLNMMRENCLKVVAHEHNSIDEMMVQYKGKTASIRQYVANKPHPWGFKIWIFADNLFTGVPLLVKIKELGMHYVGTVCKNRISGCRHEDEKKLRKEGKGAYDHCVEDSHNIIAVRWLDNKAVTLLSTYTGIEPTDTVRRWDSAVKDHREVERPAIIKAYNKFMGGIDLMDSYLFWHTLMMAIVNAWLVYRCEYKLLQLQERSMMKRQVFQSHVASALVGRMVARPRGRPSLEDVRDVIVKPQPGKVRKGPVDDVRKDAYAHWPVKVQKRGRCKLCAVNNTNTLCEKCNVRLCFVEERNCFKSYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAX0</accession>
    <name>A0A8B7ZAX0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DC-STAMP domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110985422</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102122.1">
        <property type="nucleotide sequence ID" value="XM_022246430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAX0"/>
    <dbReference type="GeneID" id="110985422"/>
    <dbReference type="KEGG" id="aplc:110985422"/>
    <dbReference type="OMA" id="NSRICAN"/>
    <dbReference type="OrthoDB" id="5985669at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058842">
        <property type="entry name" value="DCST1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF9">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26037">
        <property type="entry name" value="zf-RING_DCST1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="6">
        <location>
            <begin position="103"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase DCST1-like C-terminal" evidence="7">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022102122.1"/>
        </source>
    </evidence>
    <sequence length="408" mass="46890" checksum="023C8120900F03E3" modified="2022-01-19" version="1">MRIVIGGTRVHKTRHSETVTRALDDVRQLFNTDVDFETYWENRFNRSQTFDSIQAAIQQELEDSFSFLNLAFSVIDKIVAVSIVFLLIRSYQYHSKYRTKDRFDNCYITEEFKLLDERRQKSGREPLLPLKKSERRRLINLSSVSLSKPEKGLFKLGLVTVLLHAVIAAILILADYGLFWLLSLISRHGRVKFEISGGGGTDLTIGGSGVLSKLIQSLFVEGFAAASEFNVTLDTEHCLPNPVPPNEILSVGIGVLYLTALVMVLFQAYALRLRRRIASYFYPEREQERIHYLYNHTLQRRQNLFKLLKQRIRQTKHEMEVEQRVSFVAYLSAKYPFWRRVFLWLGQEKRVCLGCADVDNGTFKSCGNPDCSGLYCRECLHEINSTCTLCQEIVVGSDLSIGVVEHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC14</accession>
    <name>A0A8B7ZC14_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Frizzled-9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110984665</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100751.1">
        <property type="nucleotide sequence ID" value="XM_022245059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZC14"/>
    <dbReference type="GeneID" id="110984665"/>
    <dbReference type="KEGG" id="aplc:110984665"/>
    <dbReference type="OMA" id="WSILCFF"/>
    <dbReference type="OrthoDB" id="5959102at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15909">
        <property type="entry name" value="7tmF_FZD4_9_10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000016">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000020">
        <property type="entry name" value="Frizzled class receptor 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF99">
        <property type="entry name" value="FRIZZLED-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034613934" evidence="18">
        <location>
            <begin position="25"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="395"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="19">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="20">
        <location>
            <begin position="228"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022100751.1"/>
        </source>
    </evidence>
    <sequence length="604" mass="66904" checksum="C4DA250E61EF6853" modified="2022-01-19" version="1">MAGVISQLVQTLYVFSVGVCLVCALEQRQNQCQRITIPMCLDIGYNMTRMPNYFGHDTQVEAAPRIHEFSPLVTYGCSEHLRFFLCSLYAPMCSPQVDIPIPACRPMCETVRGKCEPVMQSFGISWPEALKCDSLPRGVERDDLCMVAPNMSGANEEDQGATADPDGDFNPGGGRGVPNPTPPSTRYNGTANRRCPNHERFVMLPQTKSCVPRCDRDVYFQQSDKKFAELWMGIWSILCFVGTAVTVLTFLIDRGRFRYPERPIIFLSMCYNMYSVSYIIRLITGPRAIACGHTAGDEYYLIQEGLESTGCTVVFLIQYYFYMASSIWWVILTLTWFLAAGMKWGYEAIAAYSSYYHLAAWALPALKTIIVLTLRRMDGDELTGMCFVGNQDPEALAGFVLAPLFVYFAVGTLFILAGFFYMFRIRKVMKSGGTNIDKLEKLMVRIGVFSVLYTVPATSVIACYFYQRANLRLWELVATHSNPCMPNGDCAMAFSIPSVPVLLVKTFMLLVVGITSGMWIWSTKTVQSWEAFLGRIFGSGGHRKQAAAMSSYNAQTAGASAPTVAGQANPTPGLGVKYTRTPNPANKAHSIAYTNLEGGGTAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZD58</accession>
    <name>A0A8B7ZD58_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Carboxypeptidase B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110984857</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the digestion of the blood meal.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101126.1">
        <property type="nucleotide sequence ID" value="XM_022245434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZD58"/>
    <dbReference type="GeneID" id="110984857"/>
    <dbReference type="KEGG" id="aplc:110984857"/>
    <dbReference type="OMA" id="WSYDSGI"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000002">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000040">
        <property type="entry name" value="zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF91">
        <property type="entry name" value="FI01817P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034030414" evidence="15">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="122"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022101126.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="47057" checksum="F8B79805DA59F37A" modified="2022-01-19" version="1">MAVLRFILLAALLGLCPAEKKRYDGYKVLRVTPGDDFQLQSIVNLERMLEDKVDFWASSHHIGKSVDLMVSPEDEHSVQALLDQQGLESTVWISDVQQLIDETTPEEREENIAGLANFRYDRYHSFDDIIKWMKDVAAEHPNIASTQDIGSSYEKRVLSLLKLGKPGNGKPIFWLMSGTHAREWLSPATLLKIVDLFLTNYGNGNSDVVNLLDKVDFYLMPMSNPDGYEYSRSRDRMWRKTRSTESLWCTGTDPNRNWDINWGGTGSSGNPCSQTYRGSSAFSEIEVKTVADYVRGLQGVKVFIDLHAYSQYWTVPYGYKYARPPTYTDLMTVTNKAMAALKAEHGLTFATGTTAEVIYLASGISADWAYEKANIPYCFAPELRDKGYYGFLMPESQILPSAEEVFAAIKVIGNYII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDM5</accession>
    <name>A0A8B7ZDM5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aggrecan core protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101301.1">
        <property type="nucleotide sequence ID" value="XM_022245609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDM5"/>
    <dbReference type="GeneID" id="110984946"/>
    <dbReference type="KEGG" id="aplc:110984946"/>
    <dbReference type="OMA" id="NETDSEC"/>
    <dbReference type="OrthoDB" id="2142683at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034495663" evidence="2">
        <location>
            <begin position="31"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="100"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101301.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="39938" checksum="DD5E293B2BC7EC2F" modified="2022-01-19" version="1">MPPNTRRSRWTQTVGLCLLTLLARIPTTGPSENSTDPTLASFSHPATASSATESGQEGFTSVTNTGSELTTIPAAPSDTTISIPGATPAAVQCPQGWLEHLERCYDLVRDREVTWHDAQLACQQRPGGDLLVLNSTEEKNFIDRSVSYGIFNGTANLWIGLRRDCSNSNHNFTWIDGVGLSEEVKNWESGQPNDFYSCDCPQWPNRGDTNETDSECCVDLRAGNRKKPGIFRDEQCVKLQGYICEAPKDPPVEEPSPSPSPSPSPSLERPPETSTVMEVQTVSSTVLYLTTAIQLYSSIASSSLPQPTPSPSFSEFTPFPSSSSVPTPLPGTTPVPVVCRAEILDGLQWAETPQNTVATQTCPENPFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDM6</accession>
    <name>A0A8B7ZDM6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein fem-1 homolog C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110985852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the fem-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102945.1">
        <property type="nucleotide sequence ID" value="XM_022247253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDM6"/>
    <dbReference type="GeneID" id="110985852"/>
    <dbReference type="KEGG" id="aplc:110985852"/>
    <dbReference type="OMA" id="FMTTEWR"/>
    <dbReference type="OrthoDB" id="4429489at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000104">
        <property type="entry name" value="Fem-1 homolog c (C.elegans)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF85">
        <property type="entry name" value="PROTEIN FEM-1 HOMOLOG CG6966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="502"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="548"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022102945.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="71478" checksum="90545D54CAD420CD" modified="2022-01-19" version="1">MKMSDDENLISGTDPNFYQSFKTPIFKAAQEGDLHRIQECLRSRTKEEVKWLVSQVVEKTTPLIAASRHGHLNVVNYFLEECKADVEQVGSVTFDGETIEGAPALWCAAAAGHFATVQSLMRHGARVNQTTFSNSTPLRAACFDGHFDIVRHLVQHGADIELANRHGHTCLMISCYKGHYDIAEYLLSLHADVNRKSIRGNTALHDCAESGSLAIMKLLLKHNAVMDIDAYGMTPIKAAAVAGHSNIVDYLVTVSDVPKIEKVESLELLGATAVDKKRDMHQALRYWQRALDERSSDPANIIKKVPTKAIPAYECSIEVDSTRDLENMIGDPDEMRMQALLIRERILGPTHPDTTYYIRYRGAVYADSGNFDRCITLWMYALDMQQQALEPLNPMTQSSLLSFAELFAYMLSERNGERVCSDLKYSTVSVVYLKGISEIKRGIEEAPIGPPSDKDAANFHRALLILMHLMCLIAKLDGTVEEEDEVRQATYRFLKLKPTGSKGATPLHLAVEESTSSVGRYPVCRFPDYRVLRLLLACGADVNRSNTEGNRPLHIAAKGSSDGLVKHDRSDILRMLLDHGAHLDCRNDSGKAPLDLLGDALCDISPINYTTLQCLAARAVMKHGLKYIGIIPKRLEEFVKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE15</accession>
    <name>A0A8B7ZE15_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Probable NADH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110986378</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103893.1">
        <property type="nucleotide sequence ID" value="XM_022248201.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103894.1">
        <property type="nucleotide sequence ID" value="XM_022248202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE15"/>
    <dbReference type="GeneID" id="110986378"/>
    <dbReference type="KEGG" id="aplc:110986378"/>
    <dbReference type="OMA" id="DHCIFLD"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="54"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="External alternative NADH-ubiquinone oxidoreductase-like C-terminal" evidence="7">
        <location>
            <begin position="399"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022103893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103894.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="51856" checksum="E192BE83C5CB34F1" modified="2022-01-19" version="1">MRGQRLKVRLFSSVALPSSSHRLQHPVKIIARHVIYRYASQSASSVSGVSERQKLVILGTGWSSYSVLKNINKTLYDVIVVSPRNHFLFTPLLASTTVGTLEFRSIIEPVRNTGFRKTDHFHLSEAVGLDVDKKELYCQSVIKPDMTYPLSYDKLVIGVGAVSNTFGIPGVMEHAFFLKEVSDARAIRNRILNNFECALHPSISQAEREKLLHIVIVGGGPTGVEFGAELYDFVREDVSRLYKEEQGLICVSLIEGRQILSSFTPKQQEYAEIKIRNRQQMELITANVTEVRADGVTLSNGRNLSSELVVWSTGLSPRPFVKELPFAKNNHGQILTNEYLRILDDDSGSVYAIGDCAEIQDFNLPCTAQVAERQGRYLAQTLNKNSGKDGPSFQYQSMGMLAYVGDYRGLANTPVIKGQGFYSWLLWRSAYLTRLGSWRLRMQVPIDWTKTLLFGRDTSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEV2</accession>
    <name>A0A8B7ZEV2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleolar complex protein 2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110986551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104188.1">
        <property type="nucleotide sequence ID" value="XM_022248496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEV2"/>
    <dbReference type="GeneID" id="110986551"/>
    <dbReference type="KEGG" id="aplc:110986551"/>
    <dbReference type="CTD" id="26155"/>
    <dbReference type="OMA" id="GCLRYYL"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="700"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="800"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="845"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022104188.1"/>
        </source>
    </evidence>
    <sequence length="861" mass="98527" checksum="A1494E48D67C756E" modified="2022-01-19" version="1">MASKCSHRKKIEDMTAEEMMAASDSDSGSEWSNPEEDVGEDGDKNVEDEEDDDDDDSEDEEGDVVEEDEEEVLVGEKEYGGPEETTIEGKKMSKHKQSLEKLKETDPEFYKFLQENDQELLAFDDSDDELSSDEEGALHELPDKLEEQVDSDDEDYVAGGDRMKPPKREGKDVTLAMVDKWRQQLEANSLNSFQEVVKAFRAAVQQISSAQEGNKYRVEGSGVFNAVVSLCLKHVHPSLQNILQLEDKPTKKRNLPSSSKRWKQVQASVKFYLTDIMKLLKQLSETTIVCVVLRHIHRMIPYFCCYPRLAKDLVKGLVGLWSTGEEAVRVLSFLSLFSIHRCMLKNGWLEYILKQMYLAYVRNTKFTSPSTLPLINFMQRSLTEMFAVNTQLAYQHGFVYIRQLAIHLRNAITVKKKDTYQSVYNWQYIHCLNLWCRVLATLHADETLHPLIYPLVQTAIGVVKLIPAARYYPLRFQVVRSLNLLSEATGTFIPLLPFLLEIFEFTDFNKKHSSISFRPLNFAVMLKVSKSQLNERAFKDGLIDQLYELLLEHLQVHSHAIGFPELALPVIMQLKAFLKKCKVANYCKVIKGLLEKVQETCQEINRQRDSVTFGVSDDAAVKAWENKVKMQGTTLSKHYATYKNLREKELRREEAGKETMTDDIPTLHKRQLQRKEEDKRQFGELFEADSDSEDDILVRAERKQERYTPSKRGQKRKNDNLNDDGSDNFDDDEGDDSDEDDDGTDEAESGEDATEAWAAGEGVRAKVNPMSKVKGKVKVLEEGEDKEDIVRDFDFWCDEESEGVDSKKKKKNVGGLKKKSGKKLTGRQKSIKEGNFKKTGFTSNKGKKVRVEKKVKPRPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF35</accession>
    <name>A0A8B7ZF35_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Sclerostin domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110986597</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sclerostin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104273.1">
        <property type="nucleotide sequence ID" value="XM_022248581.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104274.1">
        <property type="nucleotide sequence ID" value="XM_022248582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZF35"/>
    <dbReference type="GeneID" id="110986597"/>
    <dbReference type="KEGG" id="aplc:110986597"/>
    <dbReference type="OMA" id="IRSCKCK"/>
    <dbReference type="OrthoDB" id="6624188at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008835">
        <property type="entry name" value="Sclerostin/SOSTDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14903:SF6">
        <property type="entry name" value="CTCK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14903">
        <property type="entry name" value="SCLEROSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05463">
        <property type="entry name" value="Sclerostin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01225">
        <property type="entry name" value="CTCK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665706" evidence="10">
        <location>
            <begin position="26"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="CTCK" evidence="11">
        <location>
            <begin position="84"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="180"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022104273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022104274.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="27046" checksum="323DAD7F14CBF24C" modified="2022-01-19" version="1">MWISVRRLWLGAAILWSTMLCIASGVVVDTEVDSETDFLPVVLAHEEEQSDRGGSLHESGVFEGALHYVDEETEASYSQDDLSCTELRSKRYISDGFCTSTRPITEMVCTGECVPRSLLNEGADIVKVWGRTKTKEWRCVNDVVKLRRVHLVCNNGETRTYRIRTVKSCKCKRYDKRHNDSDLENTNENANEERPSREDRRRDRRKQKRQNRERSNRRNDREKRLASFPEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF96</accession>
    <name>A0A8B7ZF96_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110986619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022104328.1">
        <property type="nucleotide sequence ID" value="XM_022248636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZF96"/>
    <dbReference type="GeneID" id="110986619"/>
    <dbReference type="KEGG" id="aplc:110986619"/>
    <dbReference type="OMA" id="RNEHWME"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022104328.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="44243" checksum="97A6ECF512F33D5F" modified="2022-01-19" version="1">MVCQPTRRLSRMVNNKRIFVCCLCLALVAVALFIMQPYDSYYAYSGRFGSLGKGTNRDTFDFMSRRQLFSVGLSGSNRSKTWEDEQAFRKKLVSDTCQAVRKRSKGIYPRLVYNLTKAHDDHLLKFLLVVDSLKTVYCYVPKVGTTSWKRLVLFLEGKVNSTDEVGQKKTHNLTNIFIRNLNSFTLEEVTKVLASYKKFLFVRNPFERILSAYQDKFQNDYPASTVFRRIWSERIIRYSSSDQTEALPGGKRRSDGTLNVSFPEFARFVGESLDSGVHNSRNEHWMEVYRLCHPCAIEYDWIGHYESMQTDANKILRAVGVDPAVKFPNFTTNPTDSSSYSTLQRYYSQLSTDDIVAVYKKYFLDFFMFGYDIPSPIKLIMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFU3</accession>
    <name>A0A8B7ZFU3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Myb-binding protein 1A-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110986287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103735.1">
        <property type="nucleotide sequence ID" value="XM_022248043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFU3"/>
    <dbReference type="GeneID" id="110986287"/>
    <dbReference type="KEGG" id="aplc:110986287"/>
    <dbReference type="CTD" id="10514"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="819"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1187"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="712"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="757"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1198"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022103735.1"/>
        </source>
    </evidence>
    <sequence length="1221" mass="137865" checksum="FC6DC9A88F076074" modified="2022-01-19" version="1">MAAAEKLHVDAKVVESKFQKHPERQSKQDKQLLETFWDLAATLDGKRVGAAGRLIDIVSRRQADHQRDGTASMTATPEALCEEVQYTLKRLIRGLASPRKGARQGYAMALAQLLEHIEQITLGDVFKLIKEHLETKGLKSEEKQCLFGKAFAYLSIIQSGKLQKEDGRFSAEVIRQLQNLCVQKGFLEDICFRAVIDLISRSKLVAFEEDIWPTLQRELRQGWGSCNPYTLAMLAACKRTFPSIVDKKFMQKHWEHADLLDASNLPYIARIIANSTTTSHPHPHAVCDILLSWVLEKREKLPIFWNKVVDGHLCTSTQDECVFLAFRLLEAVLPACSTAEIPRVLSKNLLRSFISSLANRQAGLYAAANKLSSSLASLVKNMEDSATQLAIVKGLLLSPGHFNFDEITKSRTVYSIISNFNSDAVRLYLRWLKELFNTGSVNAGSNEPRDVDSGRHWVSMQVLSLVRNPHLQKDTDWLSDCFQFLFLHAFFRVWKATKDIPNCGRVLDVPVGESLRQQMAQHFYSALGVVCNLSTRAPVEPEGTSAESGELWVYVIVTYAQALLNSPDVNRAITFSDEAQGAWAEMLSVVDKLRKKSKLAKSPSAGPAFQLLFLHVGLQMFSETQQAVDILQDLHGCYERAVSRRRSLKKKTEDEPEWVEVVTEILLSLLSKPSHLLRTVVDGVFKMICPHMTPEALQLLLDILDPTKEVEDGNMEITESDYEEDAEMEEGSDDDDDDDDGEEQEKNDKVMESTPVSKKKRLSNGHGNHTNKKQKPSSEDSHNESENSEDSESGDENNEDDEDDDVDEFFRNDVKTALGDAAADEDDSDDDDVASNFDDDTMMRLDTALSSLFKAKMADRRKGKKETNTVLLHFKLRVLDLLDIFIKRQQSNPLILELVLPLLVVAQTASVHKDQHVLSEKAVSIFHNKLCRVRKYPHNLTEQRELLHDTIEAILQIAKKATSVMTVSLSSTGCLFLIRVLRGNVEMTDLSPVKTRHQRAEEKKASSVTQENVPQSNMLDVERISKLYCSALEDFMTHRSTNLHSLLFSELIERFPNLAWHFAEDLVQYISTGCQLYRKTQACRLLALLMSSRPVQGDSGRWSNTSERLLKDGLEVLQSMLDGEQVIKPKFLLQLLILLREFANACHCVNKLPNFSKMESRLEELQKKVEVSRSGELTSAVRSVLKAFSNRPADTRGSGKRNKRKKHKRNKKSKRSKPVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHP1</accession>
    <name>A0A8B7ZHP1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105099.1">
        <property type="nucleotide sequence ID" value="XM_022249407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHP1"/>
    <dbReference type="GeneID" id="110987022"/>
    <dbReference type="KEGG" id="aplc:110987022"/>
    <dbReference type="CTD" id="51386"/>
    <dbReference type="OMA" id="AGWFIRN"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="312"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105099.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="64094" checksum="FB58C3008B0CAAB0" modified="2022-01-19" version="1">MSRARYEVDYEDDDYDYFPDESYGMHTGDPQRDLAYERQLPNHASSYILPDEIKSFLMFFQRSVKENQLYDISLCYERDFNKLTERYFKNSSWPDAESIQAAVGPDLVFNILYKELYYRHIYARVQSGPSQEQRFESYYNYCNLFNFILNAEGPVRLELPDQWLWDIIDEFIYQFQEFSKYRSKLSGKTDDEIAILRANPKIWNVHSVLNVLHSLVDKSNINKQLEVYANAGDPDSVAGDFGRHPLYKMLGYFSLIGLLRLHSLLGDYYQAIKVLENIELNKQTLYSRVTACQVTTYYYVGFAYLMMRRYQDAIRSFTNILLYIQRTSRMMPPGSYQVDLIKKINEQIYTLLGIALTLHPMRIDESVHMQLKEKMGDKLTKMQKGDMQTFEECFSFSCPRFLSPVPPNYDIAQGNFHREPFSLQMKVFREEIQQQLAIPTIRSFLKLYTTMPISKLAAFLEMSEEDFRTHLLCFKHKMKNLVWTKGTSGLAGDFQSASEVDFYIDQDMIHIADTKVARRYGDFFIRQIHKFDEFNRSLKKPVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJ76</accession>
    <name>A0A8B7ZJ76_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Direct IAP-binding protein with low pI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110986051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Smac/DIABLO protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103341.1">
        <property type="nucleotide sequence ID" value="XM_022247649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJ76"/>
    <dbReference type="GeneID" id="110986051"/>
    <dbReference type="KEGG" id="aplc:110986051"/>
    <dbReference type="OMA" id="PGNQKFG"/>
    <dbReference type="OrthoDB" id="6153032at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008631">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009062">
        <property type="entry name" value="Smac/DIABLO-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015142">
        <property type="entry name" value="Smac_DIABLO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32247">
        <property type="entry name" value="DIABLO HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32247:SF3">
        <property type="entry name" value="DIABLO IAP-BINDING MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09057">
        <property type="entry name" value="Smac_DIABLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46984">
        <property type="entry name" value="Smac/diablo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022103341.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="27548" checksum="9539638229F60A19" modified="2022-01-19" version="1">MACRGLKRFVFCERFWSVLYQRQAVCIPSSHCLQPPRVQATSLLRPWLVRLCGLGTGGVLLSAIPCVPLSSNDKHSSAHQGSATSLQSDAGSLSHHELIKNAAAIAVDSSCILLTHSALAAISLRKEYAEMVTSLRLLLEDHAQFVGTPAQEDDLWQDIIHQRVEIDNKMQAIEDANVMLTSAILVVERAAEAAYQADAELSALTAGQHLQLVQAQLAVASKVSQKAKEQLATMQAQMIKAAAADGGDSNLEEVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLX4</accession>
    <name>A0A8B7ZLX4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Complement C1q tumor necrosis factor-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110987458</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105895.1">
        <property type="nucleotide sequence ID" value="XM_022250203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLX4"/>
    <dbReference type="GeneID" id="110987458"/>
    <dbReference type="KEGG" id="aplc:110987458"/>
    <dbReference type="OMA" id="SDNTHLA"/>
    <dbReference type="OrthoDB" id="6144194at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034538183" evidence="5">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="142"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022105895.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="28371" checksum="D01F8D4C52F50A0C" modified="2022-01-19" version="1">MHICLATILSIAILLGDSIKLQAAITGPVPRNSDGSESQVCPVCCQQGPAGTPGIPGLPGSQGLYGPAGSKGDAGEPGEKGEMGPIGAVGERGAQGNPGPKGGEGIGLPGMRGSQGPPGLVGPTGEAGVKGQKGEPAETPGNPAHPVAFSVRRRSSTDTSSSDNTHLAFEETETLLPGTSFDLSTGTFTCNVPGTYVFMFSVLKHSSSSYIRVHLKKNNEFIVSGHGNDSGKYEQVSGSAVLVLQQGDTVYLTMHGKAHSGSVYHYTSFNGFLLYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMB5</accession>
    <name>A0A8B7ZMB5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106758.1">
        <property type="nucleotide sequence ID" value="XM_022251066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMB5"/>
    <dbReference type="GeneID" id="110987907"/>
    <dbReference type="KEGG" id="aplc:110987907"/>
    <dbReference type="OMA" id="CIHGAAH"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="219"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106758.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47373" checksum="5C128E614D5536A1" modified="2022-01-19" version="1">MFYMTLIELIRPLESCLTFQETTLLIAVLPPYFRTMGKLKRLGLTYEGNVNLFSQGDVIKGEVVLMVDNDKGYGLKDVKGIWVHFQGKAKTKWTTTGNKRTHTHTLKEIYFNDNAVVFGRGKYQREEKGLHIPSGRSSFPFQFRLPMTPLPSPFEGKYGYIRYRAKATVSLIRTFSNKDYKCEKLFSMTGPTLDLNLNPATQSEVQHRKEMFGCCGCGCSPETIITAGLPKKGFVPGEGIYVIGHVDNRDGDENRMFQAILFQYITFRSRGNTKTKKYSLKELQSRVACPKGQVTDFNMGPLTVPPVPSSGLPGCNIIEIAYFVKIESSEFQAKFNVVIGTVPHRTVTRPPSAVASAPPADVAGIELSGLTVNPSAPPPSYEEAVGVIDRLTREGNSEDYFNQDQFVPRYPYFNLTVDVPPAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNR7</accession>
    <name>A0A8B7ZNR7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bile salt sulfotransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110987780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106540.1">
        <property type="nucleotide sequence ID" value="XM_022250848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNR7"/>
    <dbReference type="GeneID" id="110987780"/>
    <dbReference type="KEGG" id="aplc:110987780"/>
    <dbReference type="OMA" id="TISARCI"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="39"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022106540.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="33562" checksum="C6CDD4941F488251" modified="2022-01-19" version="1">MDKVVSYEDSVHVVDRSVFPRCITADILKEIKELTVREDDVWLCCFPKSGTKWCASIIYHVLSLRGLLDTKTTDKEIGMPIEINFPIESVLRDFPNARLRHHVIAEWQSPRILTSHLEVRRLPDKIFTRKPKVIYVMRNPKDSAVSMYNYQPPSCPYVLKWETVCQTYLHGEFAFGPWWDHVRGYWGHRNEDNFLILSYENMKQDPASAVQKISNHLGVTLTDNEVRGVVEATSFESMKKRAVNTPLHRHFRTGQVGNWKNYFTVAQSEAYDAKVERFCQETGITFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQ64</accession>
    <name>A0A8B7ZQ64_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110988098</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107035.1">
        <property type="nucleotide sequence ID" value="XM_022251343.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988098"/>
    <dbReference type="KEGG" id="aplc:110988098"/>
    <dbReference type="CTD" id="5189"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001852">
        <property type="entry name" value="Peroxisomal biogenesis factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000105">
        <property type="entry name" value="PeRoXisome assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000004">
        <property type="entry name" value="Peroxisome biogenesis factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="747"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1048"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="341"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1278"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1500"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1310"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022107035.1"/>
        </source>
    </evidence>
    <sequence length="1521" mass="168409" checksum="FE96B633F22BB211" modified="2022-01-19" version="1">MALRIAVVDFTPMKSCFISLPVTWGQEFQRKQSYIFELQWGDRGRAYVSWAGDTVRLPEGHADRTPMIQINGLYGNKLGLCHGEEILLQPVPKVHSCSRVSVEPATSDDWEILELNTGYVESNLLNQVRIVWTGQILPIWIEKKICIFIRIGATDPPASCVQLEPNTELIVAPKSRRNQAPAATPVTNATPHPNQLTGNPDREHSERRLDTSLPSSSSMGSIIGSVLSGFTSDYDSATSPSDTTFSTARLTDASSSATTPSEPWDIPTEVLDKSIPWSYRFWRRIRSVFVSDEAEHISKMAGGDMEEARRKMAAEFWKDVRIIARVQPMFEHRESSVSRVSSYSGLLKSQDPKQIPTSKRHHIHVAPSSAVPARQTRPMDSPDCPSLSPDTPRDSFTGSSYTHLMQPTTVYLSSNCETEFVRHHDSNTDEHQCPVNEFVTFVANLAKLPSPREKKEEVNRKFQQTQSKYEKAIREVMEQQKHPQMNTTTPTAKDAAAKGEDSSPSCVVRVIIHSNELRQHQNGQSENVYSSNTFQKQDITWFIQIPDLLRRQLGLESSAKVELRPVLIPPVPIHSISLFPLFDKPSDLTVEDLVFAFEYWVTCVSCMISPIPIRQHGTLLRFPISRTGDLHGEFLISINEQDRLAPSSSFPSSPDDPAPPYYLLHPLVAKRCRAVIRDKITSTSKPAFIPRMPSLDVAHLDNKVGGYRLRDLGGVTGLGQQAIDYLSAALMTRPISRCLGESLLGFLQGGLLVCGPRGSGKSALCRSVCREMVQWPSLAHVSVVECKPLKGKRIETIRKIWEEAVNEAAWRQPSIILLDDMDHVTASPLGPEQEIGQEAVYHTRLADVLKDIMMAEVKEGSRVCIVATTRSKGSLHQSLTSSRGCHLFQCCLEIPSLSKSQRVEVLNSAIQSKVEIDLRTFDQIDSDKLAARMEGYVARDIVTVVERAIHAGCCRELVEGRPVLPIEPVKQGKDSVGNADEILLLQEDFEAALHDYTPATLRDVPLHSAGELGWQDVGGLRDVKESLLETLQLPAKYPSLFANCPLRLRSGLLLYGPPGTGKTLLGGVVAKECGLNFISIKGPELLSKYIGASEQAVRDLFDRAQSARPCILFFDEFDSLAPRRGHDSTGVTDRVVNQLLTQLDGVEGLQGVYVIGATSRPDLIDPALLRPGRLDKCLFCPIPCSEERVEILQALSRKIPMMDDVDLRSIALKCEHFTGADFKALLYNAQLEAIHGTLSYPEPQDGEYDLTPLTSKHCSMGADDWKLTFLESFSAEGDSYDLPGSPRRQSRQENGNSAVRFGSPQKERSNTNSDSSTNSEFVRVDLQDVNGNAGSGEGGFDVPGRRSEVKGHSPSMRQLAAAKQGRSPRPHISDIIADSIENEEVPGPMEGPLDPLYRASGQGADQPQVIYMPTLRDGVVDPSREMQENIQSQVAVIKQSYQQRTSRNQGFHDNGPKHTDGSSVIHISQLHLLRAAADMKPSVTPSERARYQSIYDNFVQSRGGNFNPTPQLTGQKRATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQT9</accession>
    <name>A0A8B7ZQT9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-fucose protein O-fucosyltransferase 1</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peptide-O-fucosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110988579</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 65 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022107938.1">
        <property type="nucleotide sequence ID" value="XM_022252246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQT9"/>
    <dbReference type="GeneID" id="110988579"/>
    <dbReference type="KEGG" id="aplc:110988579"/>
    <dbReference type="OrthoDB" id="10050276at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11302">
        <property type="entry name" value="O-FucT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039922">
        <property type="entry name" value="POFUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420:SF10">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022107938.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="51375" checksum="9149F2A008D92738" modified="2022-01-19" version="1">MFMYFHISQATRGRPRPAAHAVVEDLKLNLDLLLRVLFFKESRGKNIKMLPVHYWIFLVHFVLRLVVQRVSAEKNPTVDPKGYVVYCPCMGRFGNQADQFLGALAFIKNLDRTIVLPPWVEYGKPGSKPGSSQIPFDTYFKVEPLAKYHRVITMEIFMEKLAPKVWPHGQRKGFCHTFREANSCKMKEGNPFGPFWDNFNVDFDSYVAFGSGLSYDPSNSNTRKWNEKFPASEFPVLAFGGAPGSFPVLEQNVHLHQYLVWSDMIEEEANNFIATKIPEGPFLGVHMRNGLDWVNVCDNHIGKEKNRHLFGSPQCLGYHFEHGQVTKDMCLPPADLVKRQIRRRVKKIKAKAVFVAADADPMMTVLANMLEPLKVKVLQYDKHEPHVELAILAKADHYIGNCLSTFSAFAARERGVTGKPTSFWAHDDLLNKDEKVKKKKKKQAHADDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZR53</accession>
    <name>A0A8B7ZR53_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Techylectin-5B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110988403</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107547.1">
        <property type="nucleotide sequence ID" value="XM_022251855.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110988403"/>
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    <dbReference type="OMA" id="GINCHAD"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034901383" evidence="1">
        <location>
            <begin position="26"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="3">
        <location>
            <begin position="115"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022107547.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="36965" checksum="85DF9C771606D0DD" modified="2022-01-19" version="1">METQSIPTLFLRVALLLCLVCVISSLSVQKNPCSAVRHFAFHGAANRALKNFELHESVGGRRVVCGINCHADPRCKSFNFYEWDGTCVLNNASREAHPEDFVKTPGSVYYDADEGTALLSCSSCKQLRDAGYRTSGVYTIYPAAFSDGLEVFCDMEADGGGWVVIQRRQDGSEDFDRPWKDYAAGFGNLSGEFWLGNTVLQALTSAPGGSWKMRFDMEDWMGGKVWAEYSGVRLSGDQYTLTFNAFNVASTAGDSLANNYKFSTKDQDNDLYSPANCVFIQGGAWWHTACGSSSLNGPYLQPSDTEGGRGIYWYTFKNAYYSLKTCTMKISETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRR4</accession>
    <name>A0A8B7ZRR4_ACAPL</name>
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        <submittedName>
            <fullName evidence="7">NLR family CARD domain-containing protein 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110988772</name>
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    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108268.1">
        <property type="nucleotide sequence ID" value="XM_022252576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRR4"/>
    <dbReference type="GeneID" id="110988772"/>
    <dbReference type="KEGG" id="aplc:110988772"/>
    <dbReference type="OrthoDB" id="10034282at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Death"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="NACHT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="4">
        <location>
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            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="4">
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            <begin position="243"/>
            <end position="327"/>
        </location>
    </feature>
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        <location>
            <begin position="406"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022108268.1"/>
        </source>
    </evidence>
    <sequence length="1059" mass="118670" checksum="2C07871EC50ED9C6" modified="2022-01-19" version="1">MADWDGGESQRRLGRHHEATGQLDDDSLYSISTQIHAGEWKGLATRLGFSAAEVSHFPSDHSFTAEQINQMLVTWRNRQPVHVNQTEALCKALKEVGNAQLADNLTENQPNTGTFKKATTQRAVSCSQPPGELDDSSLYDIAEQIDANEWTRLAAKLGFNQARVSHFKDNHSNVRDQINGMLVAWRKKQPGDVNQREALCKALREVGDINLADKLSDNQPSTSKQATTQRALSCSQTPGELDDSSLYDIAEQIDANEWTRLAAKLGFNQARISHFKDNHSNVRDQINGMLVAWRKKQPGDVNQREALCKALREVGDINLADKLSEYSASDVQSLNAANICEDELKSHYDETGSFVEMNPWCDDLKKPIADMFTKLQLITGEGKTECTFESYEDMFLLKTREGKLIPMAVLSGLAGRGKTTLFGKITYDWAFGSCEVLQKYKLVFLLKMCDLKQESDLIDAVFEQLLAENTSVDRNALGSYIKMNSGKVLILLDGFDELRTTILNKSSFGSILKILNRRMCRGCTVLVSTRPSHLVRLTTKELIQQPFTHVRVMGFSEEDITEYVNKFYCDEPTKAEGLLTRIGSSDLLSVLAESPMLLLMMCSLWSEDSEFPETMSGLYHNAVDEVGKRKDVSEQEIKRVVIELGKVGLQGLLFPDQVLSFKESDFEPGVLSLALKAGILTTQRVVKGRVPHSSVQFIPKTFQEFCSALYLQNLFEVDTQEFQKILNKIMSKSPVDFEYLLRFCCGGNEACTFEILNVFLEKCKNRLSVEDRVGQLALHCYFESQCKYLPPEKFIQAVLCDSIELDGLNVDTLLSVAYFLRRVAEVSGSIHLDKIKTLTIWSCELTRSIKDIAFAMTAMTNLHDAKFIDNTANENTHVLKSLRHLPNLVSLSLCDIQFDVTTSWRMHLKELKPLQELDVSSSSLNGQDMVHVAESIKYLPNLVSLDVSLNKLVGTAASWGMYLKELKPLQRLNLSYCSLNGKDMVHVAESVKDLPNLVSLDVSLNQIVGTAASWGMHLKELKPLQRLNLRNCSLNGQDMVHVAESVKDLPNLVSLDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZS24</accession>
    <name>A0A8B7ZS24_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Diacylglycerol kinase</fullName>
            <shortName evidence="12">DAG kinase</shortName>
            <ecNumber evidence="12">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110987650</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022106251.1">
        <property type="nucleotide sequence ID" value="XM_022250559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZS24"/>
    <dbReference type="GeneID" id="110987650"/>
    <dbReference type="KEGG" id="aplc:110987650"/>
    <dbReference type="CTD" id="1609"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20803">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20804">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20854">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RA1_DAGK-theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01783">
        <property type="entry name" value="RA2_DAGK-theta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000011">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056392">
        <property type="entry name" value="DGKtheta_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
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        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
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        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
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        <property type="entry name" value="PKC_DAG/PE"/>
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        <property type="entry name" value="RA_dom"/>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24099">
        <property type="entry name" value="RBD_DGKtheta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="C1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="100"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="174"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="240"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="16">
        <location>
            <begin position="388"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="16">
        <location>
            <begin position="484"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="15">
        <location>
            <begin position="676"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1025"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1033"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1044"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
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            <dbReference type="PROSITE" id="PS50200"/>
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    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022106251.1"/>
        </source>
    </evidence>
    <sequence length="1062" mass="119136" checksum="3CF2C51DDB488738" modified="2022-01-19" version="1">MLHLCPRQHVQISMNDHLCAVFLYCKSHQHQESNGVEYRQATPRHHSPTETSHSITTIAEKQHWQPVPAADMATTAAGLFGHQVDLNPGKNSRNKSKHCGHSLYKKNFHRPTFCHHCTDMLWGLFGQGYICEVCNFVTHERCLDNIITPCTTVAADRVQVFIPSKNITPENPVAHTWSEPGHYRKKFCNVCRRKLDDSLAFRCELCEYYAHATCLDFVVSNCVKCADYDANRNLEKMKFTHHWREGNLPANSRCALCKKSCVTSECLASMKCEWCWTTAHTGCYKSFSSECNLGPIRDLTIPPYAVSMPVPNATVRGDVTAKGQGGMPAKIPPRDTHVTPPPACKRTQEEPATRNTAMMMRTRFRRYQSISSIDSPTEVKGKEDGSEDGQLLRIYDGMTSVRRKSSHTVSVAKDASAVQVVEAAMRALHISDNPNLYYLAETSENESEGQERRIGDTEHAGQLSKQLGVKIPSLILRYQETKAKKGLIKVYPGLMKVPVEYVTVSITSYISVKEIIEMALHKFGLEDEDPDMFSLVELVIEHDIHEREMDRDECPWPQLIKARRNSLLQMRQTRYQLKRTDEKKPINAAQMFVGNLPINLSEFKYKYIIKHLLEEAGCPLFTSVGKVYVQYGAAIVAFEDHDAAITAYHVLKDATYEEKPVTLLFIPEIHIDCLRPEATPLLLFINVKSGGCQGIEVFDILSKMVNPYQVFNLCQGGPLPGLHAFSQLPEYRILICGGDGTVGWVLQCLDDVGQESVCSNPAIAILPLGTGNDLSRVLKWGGGYQQGDELFSFLQAIVDSEEVKLDRWTVIFETDQSKLIECDNKSNSSNSSSGNEDMPNMFVMNNYFSIGIDADLCLGFHMAREEKPEKFNSRLHNKGVYFRLGMRKLGRRTSCKELQKELRVEVDGKPIEIPSIEGMLILNISSWGGGADPWGVDSQDTTFKKCRHDDGLLELVGLTGVVHLGQIQSGLRTGIRLAQGANIRIWLNTDMPVQVDGEPWMQLAGQVVVCRSALQATMLKKSKLKIKRRNTEPALNSNDGQTSPRREQAKLVAMKSDEGGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZT29</accession>
    <name>A0A8B7ZT29_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC110988921</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022108574.1">
        <property type="nucleotide sequence ID" value="XM_022252882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988921"/>
    <dbReference type="KEGG" id="aplc:110988921"/>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034698090" description="receptor protein-tyrosine kinase" evidence="21">
        <location>
            <begin position="23"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1201"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="31"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="262"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="383"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="594"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="700"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="809"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="915"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="24">
        <location>
            <begin position="1016"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="1302"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022108574.1"/>
        </source>
    </evidence>
    <sequence length="1608" mass="173758" checksum="FC4D016DF4364AF5" modified="2022-01-19" version="1">MASAVYISTFVVGIACFCEVSGATVGGASWVEAGGNATLTCYTSQVYTFLEWRVSAVEVTNYTAATLIVTVLVLGGVSNVIYDANTDRSHYIFDNTSGNNALRVTSVTFDDDGKYWCQVLYSGVSTTVIDSIISRVRVKSVTISSNQWVTIGQNATVTCSPGVSDSIIIQWRKSDISNTVPPTGAASSILDHESSTNMITYGRGIDPNHYDAVQSADGGIFSLTVKSVTLEDSVKYWCSYLRLIDPTNVVQIGSHIILVGVPMDHAQTLTLTLQPVSSAQGESATLTCIFLLDALGGDLRNLEWRHKGTLIADFFGGVETPDYVNGFSEPDYIVARNDKVSNLTIANVRYADEGEYSCSVMYLVTGNSPVGSATTQLMVYVLPTSIALSDSTGTYPSTGGTAYLVEGVNHRFNCTVPGINPRASFSWSVGGRNATEDNSNDIVAADGLTISSSTVTLSPVWMNHGEALLCRASNKEGHAGISGSLTLDIKVPPKSSSMTLSDANGVFTPGGTVMVDQDASHVFTCQAQSRPAGIIQWDLGSNSYQQSTIGPTTRGPGDGLVYTTSMWTFTPGRDNHRQQVKCEANTTESQPPLPSVMVTLDVNGPPSIPVITGSSSMTENVLTTLSCTADGGYPDDWSLVWSKGGSSITGPTTSSSASGSRYSFMSTLNFTPVRQDNDNIITCAARRSSGTPGLMGSLGPIDVQFCSERVSVSCPLSAASGSIEQLSCQSDSSNPATALVWSKNNVVQTSPAPVNEDGNYGGYVTTLRLTTGALTKADNGATYKCCVMTTLSCTGTVCDFCVLNVEYPPDFSVPTLMPTRPVEEGDTVILFCGADANPKPINFITWERVGSLDSLPSVYSDGTSNLTLSSITKEQAGSYRCRGNNGVPPVVHSSSVDVIVHYGVEILNKNDTSVGANTGFNATLVCVAKGHPLPRMTWQGPDGVEITNQTNPGRIFQVDTIIEGDDVYGFIIRSIVKIIQVTPMGDYGSYTCNSGNGIGMVDTLTIVLNDKVKPLPPEDVSVNPNTVTESSVRISWRPGNDGGEAQWFFVNYREVETTAVFDPDTRTRIDDDVFEYVIEGLLPYTLYEIEIFAENQNGVGKSVKQNFRTRPDTPENLGIVVTTNQETGSISVDGIPQDGDASTCLQIQARLMDQSPWFNYGGCLETNTDLAIQEVRSSYCRNGFCSLATSALSVQGQSSNAGLIAGLVILAIIALISITLNVVTIRDIRRSRGLQGENRKRVPKEYRKHTPEGKRAVINEAAEYQDLDVPLQVLAVKSSSNPGTSAYASISETVSAFSRDKLTIERELGQGAFGKVLLGKASGIVQLGTVTQVAVKTLRDDADLMERGDLLRELDFMKQLPSHANVVKLLGFCDDGDPIFIIMEYMTKGPLKDLLTSSRGKGMQVYSNLHGRSKSLTSRDLIKFAKDVAEGMAFLASQQCIHRDLAARNVLVGENMVCKVSDFGLARDIKNKRMYQRQSEGRLPIRWMALESVVDDIYTTESDVWSYGILLWEIVTLGARPYPTMSAKTMITELQEGYRMPRPDHCQDEIYQMMLACWEEESTARPSFTEIGQKLEKALESPHECITLSDYQGIQYEVTIPDSPDERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUJ3</accession>
    <name>A0A8B7ZUJ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melatonin receptor type 1B-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110989272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109233.1">
        <property type="nucleotide sequence ID" value="XM_022253541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUJ3"/>
    <dbReference type="GeneID" id="110989272"/>
    <dbReference type="KEGG" id="aplc:110989272"/>
    <dbReference type="OMA" id="PYVINCQ"/>
    <dbReference type="OrthoDB" id="6416613at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022109233.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="42683" checksum="969103CB149387D9" modified="2022-01-19" version="1">MDDIYYDEVLMSEEMMYNSTDSTPQQFEFSDYKQRVIVAILYLIMALLGIFGNTLVIIAVLLSKKLRTATNAFVVSLSVADLLTCLVLPWNAAAALGRDGPPFGEWVCSVVAVVQSTTIGCSTYTLAAIGLQRLLLITRPPTYHAIYTRKKMAAWLVVTWLVPFLFTLVPPLLDVGEVGYNRKYHHCGFTSSHERSNDYDLIIAGGLYPLPLVTILVCYVLIWRHLRRHARNVTTSSEETTESASMNLSTVCDSVGATKGRSLRRSPTPHGTLNAAKVNRSQNEITKNMFYIVCAFMVCLTPFAICLFYDDSDPFLPYASAILVFNSCINPLIYATKHRVFHVVFGCIIRRKWDSIPEPSEFLKAMRRRQFCSRSGFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUU5</accession>
    <name>A0A8B7ZUU5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">2-amino-3-carboxymuconate-6-semialdehyde decarboxylase</fullName>
            <ecNumber evidence="4 12">4.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Picolinate carboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110989332</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:16557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77634"/>
            <dbReference type="ChEBI" id="CHEBI:77803"/>
            <dbReference type="EC" id="4.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Secondary metabolite metabolism; quinolate metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.45" evidence="4 12"/>
    <dbReference type="RefSeq" id="XP_022109333.1">
        <property type="nucleotide sequence ID" value="XM_022253641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUU5"/>
    <dbReference type="GeneID" id="110989332"/>
    <dbReference type="KEGG" id="aplc:110989332"/>
    <dbReference type="OMA" id="RIESCIM"/>
    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="UniPathway" id="UPA00270"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001760">
        <property type="term" value="F:aminocarboxymuconate-semialdehyde decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901606">
        <property type="term" value="P:alpha-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170033">
        <property type="term" value="P:L-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904985">
        <property type="term" value="P:negative regulation of quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170039">
        <property type="term" value="P:proteinogenic amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01292">
        <property type="entry name" value="metallo-dependent_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000029">
        <property type="entry name" value="2-amino-3-carboxymuconate-6-semialdehyde decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF27">
        <property type="entry name" value="2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="14">
        <location>
            <begin position="3"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022109333.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41791" checksum="1C34EB5BB5D6A0AC" modified="2022-01-19" version="1">MKIDIHNHILPERWPDLKERYGYGGWIQMYPHCEGKSRMMRDGKLFRIIEDNCYKPEERLREMDATGVTVQALSTVPVMFSYWAKPEDTLDLCHILNDDLAKTVQKYPKRFVGLGTLPMQAPELAVQELRRCREELGFPGVQIGSHINDWNLDAPELQQVFAAAEEYDCAIFVHPWDMELGGRMSKYWLPWLVGMPAETATAMCSMIFGGVLEHFPKLKVCFAHGGGAFPYTIGRIEHGFNVRPDLCAVENTVNPRKYIGRIYTDSLVHDEKALQFLVATMGKDHVMLGSDYPFPLGEHHPGKLIESVQEFTPDLKDALLAGNALEFLGLERSQYESTDPVASASNTSNNCSTLPMEMEPPPKKQKLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV68</accession>
    <name>A0A8B7ZV68_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">PR domain zinc finger protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110989141</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108982.1">
        <property type="nucleotide sequence ID" value="XM_022253290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV68"/>
    <dbReference type="GeneID" id="110989141"/>
    <dbReference type="KEGG" id="aplc:110989141"/>
    <dbReference type="OrthoDB" id="7327383at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19187">
        <property type="entry name" value="PR-SET_PRDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000748">
        <property type="entry name" value="PR domain zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000132">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000211">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000262">
        <property type="entry name" value="PR domain zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016608">
        <property type="entry name" value="PRDM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044413">
        <property type="entry name" value="PRDM1_PR-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF59">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013212">
        <property type="entry name" value="PRDM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="2" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="58"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="610"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="661"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="712"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022108982.1"/>
        </source>
    </evidence>
    <sequence length="840" mass="92090" checksum="B2B9147EB24D858B" modified="2022-01-19" version="1">MKGLEPNWWCGLMRTGTMQPWTRARFDEKSYYTRCVKMGCEDDSNGWLDLEEAEYQSKCIYVVNDKPCEGDPDGCRAAASLPANLKYIERDGQIVGVIAGDYIPRGTRFGPLVGQIYREEEVPREANRKYFWRIYKAQKFIHYIDGFDPHKSNWMRHVNPANSACDQNLVACQYDTDIYFYTVKPIREGTELLVWYCKEFQRRLEQPVVMEMGTAEGGKGASSKMTSASPVDEPKHDEALDFSMTSRNTSSGKTTANAATKATSLSSATVVAAGFPERFSAKRPAAVPGFGQPMTSPQTSPVQTGAGGAMPQSMAELKPQPAHQIPKHIAEAASKAGVLIPQPIPMHVGRHQGLPFIMPPYIYNPLLVRTTLPNGMNIIPTPSILATHGFEPRLSKSDIRGNTSPKDTSPPTTSPPGTTATHLGNIFPTGVANFPLPISFADAHSQSKFKQESGKEVESNQAFSKTSTRKRPVGNTEYGHKSLEYQLPRRNGKIMYECNVCQKVFGQLSNLKVHLRVHSGERPFRCEVCSKGFTQYAHLQKHHLVHTGEKPHRCNVCQKCFSSTSNLKTHMRLHNGEKPYTCKLCPAKFTQYVHLKLHRRSHLEEGYVYDPSRETNLSPSPSPSPPSSTGCPSPAKKIKTELQGYQSHLVSTEVADYFGQTGQRSPTQATCSSAENEALPEGSSAQGTGATGSQPEEPPIPRAMVALMAGSPSSVLGLGSPPPLVPINRASPSSDNAYDKPDQFKTFTTLPDCSDKDGVRNDEAVSERDQNKEAVIGANTTANVELLSADNSKDDGGDSQRVLDGSSKSKRESSPTGQTQSQATKIENVVQKILSKAVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVG7</accession>
    <name>A0A8B7ZVG7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ZP domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110989463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109548.1">
        <property type="nucleotide sequence ID" value="XM_022253856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVG7"/>
    <dbReference type="GeneID" id="110989463"/>
    <dbReference type="KEGG" id="aplc:110989463"/>
    <dbReference type="OMA" id="KSCKPDC"/>
    <dbReference type="OrthoDB" id="5959240at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048290">
        <property type="entry name" value="ZP_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF59">
        <property type="entry name" value="CUB AND ZONA PELLUCIDA-LIKE DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00023">
        <property type="entry name" value="ZPELLUCIDA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="5">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022109548.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38505" checksum="0B4514E11E421041" modified="2022-01-19" version="1">MDCSVSGMAVFIPRSVIGDALASHLHFLDPACVGRHHNATHIKIATTYDRCGTFMEVRGDNVIFFNVIHDEAVPVEPGGVITRDRDIEIPVQCIMDLEGMAELSFRPDTSKITYYEEEFGSFNFSLGLYRTNDYATPYLPADYPVDFKMGDTLYFEARTWSEPGLELFLQTCRATPTSNSNDFHRYTFIQNGCIKDYTLVFHPSYDPHVQRFQVEVFAFMDTLPQPVVYVHCDMILCNASDPDSRCAVGCPAGDGRSQLNMHKRHARSTMSGSHVYPITQGPISLGREGGKEASSGSSSVQQPILLTTVCLSVGCVLVLGTLVAVMKKRSKRIDMYAPLALNDPDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYH7</accession>
    <name>A0A8B7ZYH7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC110988938</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022108626.1">
        <property type="nucleotide sequence ID" value="XM_022252934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYH7"/>
    <dbReference type="GeneID" id="110988938"/>
    <dbReference type="KEGG" id="aplc:110988938"/>
    <dbReference type="OMA" id="RKTTHGR"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="124"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022108626.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="48528" checksum="189993665A8199AD" modified="2022-01-19" version="1">MESINTTAYTLMKNTEKPPESDESSKHVDLITGVVAGVVVLIVIIVFAVRLSRRARSYPAVSEQTKKASRKMRRRLKSNTQEDKRANYKNILEMDAVSTAGQEQAAPSYANVCNSLIAFPRDQLTIVKEIGHGSFGLVFLAEANGIIERSKVTKVAVKTLKDEANNLQRRDMLRELELMKKLPDHPNVVKLLGFCVDQDPLYIIVEYLTRGNLKNLLKQSRSKGGRVYRNLHGISKSLASTDLIMFAKDTADGMEFISSQKCIHRDLAARNVLVADDMTCKVSDFGLARDVMNIRVYERESESALPMRWMAIESILDDVYTTESDVWSFGVLLWEIATLGARPYPAMSAKVLISELQNGFRMPKPQHCQDELYEMMLRCWNEDPASRPSFKMISDDLDRLICEGKDYLSIEDIEDAVYEVSLPGGTLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYK3</accession>
    <name>A0A8B7ZYK3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">UPF0565 protein C2orf69 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4" type="primary">LOC110989616</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109828.1">
        <property type="nucleotide sequence ID" value="XM_022254136.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109829.1">
        <property type="nucleotide sequence ID" value="XM_022254137.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109830.1">
        <property type="nucleotide sequence ID" value="XM_022254138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYK3"/>
    <dbReference type="GeneID" id="110989616"/>
    <dbReference type="KEGG" id="aplc:110989616"/>
    <dbReference type="OMA" id="DIMSCHP"/>
    <dbReference type="OrthoDB" id="419333at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018881">
        <property type="entry name" value="C2orf69_mit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31296:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTEIN C2ORF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31296">
        <property type="entry name" value="UPF0565 PROTEIN C2ORF69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10561">
        <property type="entry name" value="C2orf69"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022109828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022109829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109830.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33622" checksum="900F45D937CCE1D5" modified="2022-01-19" version="1">MAHREFMKGLTFMTLKNVTGVGSRENDILFSTVVNGSNCKHQRETAQGHVVFFPGDTQNFHEVMMNHLTNKKWASWSYENTSALLHQRFFNSYVWLIKPSRIHENTFSCYDNFLQSTTFGAPASFENFESLLHLRHILLSAISLVNTRQGNAMSVQPLSKDTPLSIIGFSKGCVVLNQFLYELESAKKNPELSDFLKLTSAFYWLDAGHSLTSRIWITDEKLLQQLTDSSIRVRVHVSPRQVRDPGRPYIGEEERVFVEVLKRQGADIQETLHFTDQERSMEQHFRILEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYW6</accession>
    <name>A0A8B7ZYW6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110990095 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110990095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022110614.1">
        <property type="nucleotide sequence ID" value="XM_022254922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYW6"/>
    <dbReference type="GeneID" id="110990095"/>
    <dbReference type="KEGG" id="aplc:110990095"/>
    <dbReference type="OMA" id="IDNWIGN"/>
    <dbReference type="OrthoDB" id="10072451at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1460.10">
        <property type="entry name" value="GTF2I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004212">
        <property type="entry name" value="GTF2I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036647">
        <property type="entry name" value="GTF2I-like_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02946">
        <property type="entry name" value="GTF2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117773">
        <property type="entry name" value="GTF2I-like repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51139">
        <property type="entry name" value="GTF2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110614.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33588" checksum="565C2A8109C83CD3" modified="2022-01-19" version="1">MTLQYALTMEHHELLGRLYDEGMTNYGTSEAKRKVEFAVKKTGLTVKQVKRWIDNKRRQQHRKEENQRPIRRRRQSGYNVFMKKYICSKGGTAPNKAMVLQQGAEEWRRMAEEEKQEYKDVAAEENKTMPNVVQLGESGFRVFANKLCKEVTDMCSRVEGVEWVLVCSNVSIGASAVCGSETGVNLATSTCFADQLCSASGYDEVTISSSVTPAEYSSKLRFKVQEIFNRKYREATGKNKPMSYQQLEAGQIQSTGLPPNVKLKRPSAYGKETLQKIIDAESAIEFTVSTQTSTLAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZ37</accession>
    <name>A0A8B7ZZ37_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110989723</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022109995.1">
        <property type="nucleotide sequence ID" value="XM_022254303.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989723"/>
    <dbReference type="KEGG" id="aplc:110989723"/>
    <dbReference type="OMA" id="VETNCIS"/>
    <dbReference type="OrthoDB" id="10041264at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041201">
        <property type="entry name" value="PTPRJ_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF3">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18861">
        <property type="entry name" value="PTP_tm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034480272" description="protein-tyrosine-phosphatase" evidence="14">
        <location>
            <begin position="27"/>
            <end position="4491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="4104"/>
            <end position="4131"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="3481"/>
            <end position="3570"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="3571"/>
            <end position="3667"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="3758"/>
            <end position="3849"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="3850"/>
            <end position="3949"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="4210"/>
            <end position="4463"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="4382"/>
            <end position="4454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1739"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="4136"/>
            <end position="4188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1746"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="4136"/>
            <end position="4150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="4157"/>
            <end position="4172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="4173"/>
            <end position="4183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022109995.1"/>
        </source>
    </evidence>
    <sequence length="4491" mass="478636" checksum="A163ED1D87CCD65A" modified="2022-01-19" version="1">[encoded data, 4491 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZK2</accession>
    <name>A0A8B7ZZK2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Acid-sensing ion channel 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110989154</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109006.1">
        <property type="nucleotide sequence ID" value="XM_022253314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZK2"/>
    <dbReference type="GeneID" id="110989154"/>
    <dbReference type="KEGG" id="aplc:110989154"/>
    <dbReference type="OMA" id="YLVITIH"/>
    <dbReference type="OrthoDB" id="6154304at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034373760" evidence="12">
        <location>
            <begin position="25"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022109006.1"/>
        </source>
    </evidence>
    <sequence length="189" mass="21091" checksum="9AA41AF04EC214D2" modified="2022-01-19" version="1">MTTLLVVNTIQAILVLLRHPETSAISLNYVPRITFPAVTVCNINLLRNSALDESVIPTLAAIYLEDRSDSTGFDFGPVDALYHYPNGSDSLETIFNASHQIEDMLFRCRWRHEKCSAANFTRRLTDHGVCYTFNDPPDEQDALQVQNPGSSNGLFMRLNIEQDLYTYGESTSAGIKGFVAVQFPAGLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0E4</accession>
    <name>A0A8B8A0E4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransferase family cytosolic 1B member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110990502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111228.1">
        <property type="nucleotide sequence ID" value="XM_022255536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0E4"/>
    <dbReference type="GeneID" id="110990502"/>
    <dbReference type="KEGG" id="aplc:110990502"/>
    <dbReference type="OMA" id="RIMATHC"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022111228.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="37563" checksum="1ED1F127A6CA7CB5" modified="2022-01-19" version="1">MTENPLLSFFPAIINGKTHSELLQEIREFNTNYGHELEGNNYSWLMPKENFDALKNFQVRDDDIFVITFPKSGTHWLGEIIDYVMNDGRDDFDRTNMSAVLETTMEPDPSKVASGTPGYKILETMKPPRIMATHCLPNLLPPQVWEKKPKVIYLARNPKDLLVSYFTFIKPFVTPSLQTWERFLFMLVTGQMIGGSWFDHVLRYWEQRDEKNILFVKYEDLHKDLKGNVRKIASHLGKTFSDDVIDSIAERVTFGGMQKTYKNLEDVHGEKGKQLTHMFGMAPYLRKGKVGSWKEVFTLEQSALFDMIYAEKMKGSGLDFEFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A164</accession>
    <name>A0A8B8A164_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990650</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111419.1">
        <property type="nucleotide sequence ID" value="XM_022255727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A164"/>
    <dbReference type="GeneID" id="110990650"/>
    <dbReference type="KEGG" id="aplc:110990650"/>
    <dbReference type="OMA" id="CKRFEHI"/>
    <dbReference type="OrthoDB" id="10051466at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111419.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="51044" checksum="74958D3F997A6D0A" modified="2022-01-19" version="1">MARPLVFVYVFLVFLTISTLIYEAILPCYSSNHSSTERVSLPKHPIFFSNNSYLLATKEHTLTLTIRMAAAPKLIRRLYCDFLRSAVLFWSSKLGHISVILDKESAADHQLAARLSQQEHAFGVKFDFIYEPLPNDISILEIERDRGYSRQLWSSFFMDLYINASIIAWIDTDGMFTTPVTSENIFNGHQLRVVTFTDWSIPRRHGWDKTTKLAMGKNLVADFMTYFPVYIWRDTIRKCREHILRHMNVSNFENAFRKLKVKRARVSPVNILLNYAFYFEHDRYDWHLDVNNNLEAYNSQHVQPGFEIKPNETTPDVRVTVHAGRHFLKSPNPLLQGYCIAKRHVGTPPAACKRFEHITNFQLFEFLAERGVSFNHLATWCSPKGDGRTDCSRRIEAHYKNVGRYYNLGWFDLDLRRVSAVEKAAALGNATCPKIFDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1B8</accession>
    <name>A0A8B8A1B8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110990453</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110990453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111152.1">
        <property type="nucleotide sequence ID" value="XM_022255460.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111153.1">
        <property type="nucleotide sequence ID" value="XM_022255461.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111154.1">
        <property type="nucleotide sequence ID" value="XM_022255462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1B8"/>
    <dbReference type="GeneID" id="110990453"/>
    <dbReference type="KEGG" id="aplc:110990453"/>
    <dbReference type="OrthoDB" id="261614at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017482">
        <property type="entry name" value="Lambda-type_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03033">
        <property type="entry name" value="phage_rel_nuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF6">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE_RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022111154.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29473" checksum="66B00826439F9E97" modified="2022-01-19" version="1">MGQIPLQVSPELCSEKGHAMVAQNSPEWYQLRKKMVTSSKVPALLGLRGSKCQEQMLREVMEQETEDDLKKNKRMASLPSFKRGQQYEDKAAEHFTQETGIPAYKVGIYRQGNTMFAASPDRILPGSWLLEIKTRVAGSASPLEKLDGTHFAQVQTQLYCTDRTEAILMSFLPEEQLAHYFYIKRNHVWWKVAEVILGSIVHKTKVEHWDLRETEVLRKIGNALLGQNAEFSNTKAFRSWTNDLGSTCKRVQLQASATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2M1</accession>
    <name>A0A8B8A2M1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mastermind-like protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110989797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mastermind family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110121.1">
        <property type="nucleotide sequence ID" value="XM_022254429.1"/>
    </dbReference>
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            <begin position="7"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2S0</accession>
    <name>A0A8B8A2S0_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989831</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
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            <taxon>Asterozoa</taxon>
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            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110176.1">
        <property type="nucleotide sequence ID" value="XM_022254484.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="MANGANESE-DEPENDENT ADP-RIBOSE_CDP-ALCOHOL DIPHOSPHATASE"/>
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    </dbReference>
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            <begin position="39"/>
            <end position="322"/>
        </location>
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        <source>
            <dbReference type="RefSeq" id="XP_022110176.1"/>
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    <sequence length="383" mass="43133" checksum="1F61FF6562D985BF" modified="2022-01-19" version="1">MKICPLGTKPCCYEYIMPWRKEWTCETRMENKASACVFSFGVISDIQHADIENRLNYSQTCMRYYRNALALLKEAVDHWMDGDTSAIRPDFVVQLGDVLDGFNSEGGKDESLRILDVILNQFDRLPCTVHHLFGNHEFYNFSRVELMNSRLFSGAKFETTARDSECECFPEDSLSAGKSRAGGLATYYHFSPAPGFRVVILDSYSRSIIGHNDMCPIGQESLRLVRSVNKNEILNSPLGLKVSEKRFVAFNGGLGEKQMAWLENVLEGACLAKEKVILFGHIPIYPIHRDHTCLLWDYQEALKLVRSSPCVVALFTGHTHSYAYTVDEMSGIHFLNFPGVVEIPPGGNGFGTIAVYGDRLVLHGVGHVDDVVMKFPEQSMYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A310</accession>
    <name>A0A8B8A310_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spondin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">F-spondin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110991181</name>
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    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative Spondin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-spondin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4060">
        <property type="entry name" value="Reeler domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002861">
        <property type="entry name" value="Reeler_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042307">
        <property type="entry name" value="Reeler_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009465">
        <property type="entry name" value="Spondin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038678">
        <property type="entry name" value="Spondin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038123">
        <property type="entry name" value="NF038123_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF16">
        <property type="entry name" value="SPONDIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02014">
        <property type="entry name" value="Reeler"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06468">
        <property type="entry name" value="Spond_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51019">
        <property type="entry name" value="REELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51020">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034119929" description="Spondin-1" evidence="13">
        <location>
            <begin position="26"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Reelin" evidence="14">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin" evidence="15">
        <location>
            <begin position="188"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="450"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00019594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022112108.1"/>
        </source>
    </evidence>
    <sequence length="631" mass="69181" checksum="54C0727F8C121D0D" modified="2022-01-19" version="1">MARIFIKTSAISLFYSLTLLVGTLAVPRRSCSRLPGDFSVPKRPGDNGYRIRIAGHPSFYVPGQEYLVTLSSTPPVSFREFTFACLLVSDDITPSGRFEIIDGRLSQFSPDTINCPQLLVHTSKASKTTVTFRWIAPPAGTGCVAFKAAAVQKKQIWYKDEQGLTLWLCEEDIGASVAPQISTGERDSNTECCACHTAKYTVTMRGLWSQETHPKDFPGGHGDHWSDLIGASHTKDYTIWKQGGYASLGVQRVAEWGSTTTLEREILAQTRNIKTVIRSRGLWPARGNMSAVFSVNRTHNLVSALSMIGPSPDWFVGVSWVNLCTQDCDWLQHQEIDLLPWDAGTDSGITFRSDNAPTIPTEPIHPITSSYPSNPLGAFYDPSGSPIPPLAKMVFERTDNTQYDDLGEVVCEVDVASPDTTHQGGLGMPPKEGMMPPKEGMMPPKEGMMPPKEGMSSPNGGTMPPKSGMMNKGGGEGNRTTPMMKKPAPEEIATMPPKVMPNPGNEDPVTMPPKGRRRQPIDCMMSSWSEWTECSRSCGKGTMKRQRMVKQKARHGGRACGKQKEKKNCNAGPCPRDCMMTDWGDWTPCSVTCGGDGTQTRMRKIKKKARGNGQACGPRREERVCGTATEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A320</accession>
    <name>A0A8B8A320_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Growth arrest-specific protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110991190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112118.1">
        <property type="nucleotide sequence ID" value="XM_022256426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A320"/>
    <dbReference type="GeneID" id="110991190"/>
    <dbReference type="KEGG" id="aplc:110991190"/>
    <dbReference type="OMA" id="GLHGCDY"/>
    <dbReference type="OrthoDB" id="2250192at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21204">
        <property type="entry name" value="CH_GAS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF13">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GAR" evidence="6">
        <location>
            <begin position="178"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022112118.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31813" checksum="8CE98A7373743A5C" modified="2022-01-19" version="1">MDDMDGSSEGDEYFQEIARGAEESLIPLKEDLAEWLTRVLGEKITTTGFMDSIANGVLLCKLAQLIQDKAVECQRAGKAIGKMPSKKLKYRQNAVAESFFARDNVATFLAWCRGIGLEDTCLFETEGLVLQKTPQNVLVCLYELARLAGRYGIDPPGLVKLEKEIEKEEQNPRPASAVTKKKATSLLDTEVMNVAKQCDFGLDIRRVSEGRYNIGGKMVFIRMLRGRHVMVRVGGGWDTLEHFLKRHEASKITRVSRGSITTEAGEAVPDDFFLVQAKYKKDGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A6R5</accession>
    <name>A0A8B8A6R5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990918</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111691.1">
        <property type="nucleotide sequence ID" value="XM_022255999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A6R5"/>
    <dbReference type="GeneID" id="110990918"/>
    <dbReference type="KEGG" id="aplc:110990918"/>
    <dbReference type="OMA" id="WVINANS"/>
    <dbReference type="OrthoDB" id="8046937at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="861"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111691.1"/>
        </source>
    </evidence>
    <sequence length="969" mass="110021" checksum="29AB96AF53F9FC99" modified="2022-01-19" version="1">MFHQVGVNVEHRNYLRFLWLEGGDIEKRPEEFRMKVHLFGETSSPACANFALKSAADAYENTHGKAAADFVRREFYVDDGLKSVTTPEEALELIETRVNLCEQSGFRLHKFIANNKDVLQAQAIPPSERAKDVQNVKVLSEGFPVERTLGVQWCVESDTFQFRVHFSDKPPTRRGIMSSVSSIFDPLGLVSPVLLVGKQILQSLCRDGYAWDDPIPDETRAEWEKWRLDVCDLVSLKIRRCYKPESFSSIQSAELHHFSDASAEGCGQCSYLKLIDDTGSVGTTLVMGKSRVTPSKPVTIPRLELTAAVTSVKVSTFLSRELEYKNVKHFFYTDSKVVLGYIANDSKRFHVFVANRVQKIRDSTTPDEWRHIDTKMNPADPASRGLSAGALIDCKLWWKGPAFLQTADAPPRNDEPAELSSTDPEVKKASVFNVEAHAPTFPSTLERFNYFSSWFRLRRTVAVCLRYIERLKRRIKGESATPPDAYSPITVDELCLAEQRILHLTQQQAFPEEIRVLNKQDGGSLDIQRQSTKPLSKGSPLRTLDPILDEKGLLRVGGRIKQASVSEDVKHLIVLPRRSHPTELLIEHYHSQSCHAGRGITLNNIRQAGFWILGARAAVASHTWKCVTCRKLRGAPCGQKMAELPADRLNPSPPFTYSAVDFFGPFLIKDGRKEMKRWGVLFSCMASRAVHIETANSLSTDSFLNAYRRFTCRRGPVRQLRSDRGTNFVGGRSELDDALAEMNQPKICRELLQDGCDWVTFNMNVPSASHMAGAWERMIRSIRSALSALLHRNGCQLDDELLRTLMIEAEAIVNSRPLTYVDTKEPDVPEPLSPNQLLTLKGKVVLPPPGVFVQQDLYSRRRWRRVQLLANQFWSRWKSEYFSSLQERKKWTKSRRNIVKDDIVLIIDDNAPRCHWQLARVIETFPSLDGYIRKVKLQTSRSILERPIHKVVLLLDRDTPPRSQETEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XFL7</accession>
    <name>A0A8B7XFL7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110973212 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079553.1">
        <property type="nucleotide sequence ID" value="XM_022223861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XFL7"/>
    <dbReference type="GeneID" id="110973212"/>
    <dbReference type="KEGG" id="aplc:110973212"/>
    <dbReference type="OrthoDB" id="9986415at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034327036" evidence="3">
        <location>
            <begin position="24"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079553.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30269" checksum="2949F7257B59DF1A" modified="2022-01-19" version="1">MGRILRFLVGGVICLCLQGLASAALPPCVKVDDCSCKTITDSGEQAINIRRLGSQDEAEAPRFGFKQYNPAEPWEYAYNPCYPWSDGTTNCKDVVVCQRSVYHPDQTFGLGDASANWTDDGTHYYIVHTHTTRTTYIKLRCDASAKTPKFDYYKDQSSEYTFTLTTECACPGTCHSLPPTAPPPTGSMPSTLSIGSILCVVASVLLLVYAVGGVLFMKCVRHAEGMEVVPNIDIWTSLFRNIRDGCVFVFSCGKRSGYGASYTRAVEQDPNNSNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XI75</accession>
    <name>A0A8B7XI75_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alpha-L-fucosidase</fullName>
            <ecNumber evidence="6">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110973744</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:0) + H2O = a neolactoside nLc4Cer(d18:0) + L-fucose</text>
            <dbReference type="Rhea" id="RHEA:49308"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:91119"/>
            <dbReference type="ChEBI" id="CHEBI:91121"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:49309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a neolactoside IV(2)-alpha-Fuc-nLc4Cer(d18:1(4E)) + H2O = a neolactoside nLc4Cer(d18:1(4E)) + L-fucose</text>
            <dbReference type="Rhea" id="RHEA:48224"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17006"/>
            <dbReference type="ChEBI" id="CHEBI:28691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48225"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022080494.1">
        <property type="nucleotide sequence ID" value="XM_022224802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XI75"/>
    <dbReference type="GeneID" id="110973744"/>
    <dbReference type="KEGG" id="aplc:110973744"/>
    <dbReference type="OMA" id="ILWYDVP"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000013">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000027">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034431722" description="alpha-L-fucosidase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="12">
        <location>
            <begin position="23"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-fucosidase C-terminal" evidence="13">
        <location>
            <begin position="368"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022080494.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="52722" checksum="57A5DBC784BCE7C3" modified="2022-01-19" version="1">MGLISALVLLVICVWPPVLGAVGKYEPNWASLDSRPLPPWYDEAKIGIFMHWGVFSVPSFGSEWFWWNWQGAHDAAYVNFMKQNYPPGFTYADFAPHFTTEFYDPKTFAEIVQASGAKYVVLTSKHHEGFTNWPSKYSWNWNSMDVGPKRDLVGELATAFRTYAKDVHFGLYHSLFEWFNPLYLQDKKGGFKAQEYVRDVALPELYEIIENYKPDVLWSDGDWEATADYWNSTEFLAWLYNSSPVNATVATNDRWGQGTSCKHGGYYTCHDRYNPGVLQKHKWENAMTIDRKSWGFRREAVLADYYDMEYLTKTLAETISCGGNLLMNIGPTHDGRIVPIFEERLRQMGTWLKVNGEAVYSTKPWVAQNDTMTPGVWYTTKEGPVYAIVLDWPANNELDLGVPMGKVGQTKVSMLGYNMPLQWRPLPSGKGLNITMPALNEAQLPCQWAWVIKMDNLVMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJH6</accession>
    <name>A0A8B7XJH6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynein heavy chain 6, axonemal-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110973526</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080100.1">
        <property type="nucleotide sequence ID" value="XM_022224408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJH6"/>
    <dbReference type="GeneID" id="110973526"/>
    <dbReference type="KEGG" id="aplc:110973526"/>
    <dbReference type="OMA" id="NEEWINC"/>
    <dbReference type="OrthoDB" id="5986589at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynein heavy chain ATP-binding dynein motor region" evidence="2">
        <location>
            <begin position="151"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain AAA lid" evidence="3">
        <location>
            <begin position="798"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein heavy chain C-terminal" evidence="4">
        <location>
            <begin position="988"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022080100.1"/>
        </source>
    </evidence>
    <sequence length="1268" mass="142396" checksum="E713375559E26E95" modified="2022-01-19" version="1">MRACCIGRQRQWPLLIDPDDQVVTWVKLLQEKGVVSFHEGMALEEGSETPALSIANVNELDDLDDSLSRETPTTKPTSRGTSMDDWDIATDYPETPRTLTSVGGDTQYNMRHSFNFQSDGDYDLSASNTFQDDSFLLESLPEDDADVQKPADNLWIISADNPSLEIRLIQAMLLGVAVVVSHLERKALGGRLVELLRRNVKYGKEGERRILIGGREYGYRPSFCLYLCSSVPLELTGSGFAPLPIEDTSVIDLSISPQGLTDRLLKHIMLIERPEFHGQWRSIEGDIHNQEATLQQAEEDILNKTLGLPHSILDEPTMTDAISHYQQCTLTTDASLHQTHTLAAQLRQKQEPYLPVAEHGTLLYSVIKRMSNLHPLYYVPMATFVRWFQSTVTSRQKNRADISSAAARAVELTNVIMLDIQARVSLGMFQPHTQLFAFLVAVEKMRAAKAMTEEEWLMFVGGANITNQTAPERDINLPDWITQKIWSSCSQLEKEFPAFHGLTRSVLNHSHQWKEYFEHDPVLLAPIPGTSLANLTFTQKALLWRVVRPDKMFSVCRDLTIYQLGSYIARPSFCNVEDVLNHCDQHTPVVFVLPAGYSVDGAINSGCEGHTDTHPITKLTGYCRQQKPERTLHTVSLGTQGQIQKVLLALEECSETGIWLVIDNFDLMDDEGQEILNFIQKMVSSGKEAPSVPSAPSRPQTKQSSKSLASRSGSEAQAIPSPEEEPKSGIHTEFRLFLITRADSRYPMPGLILQHGIKVTCEVTANLRESLRHAFNDGMRALEASKLMVTSTTAKITNEMVFCISLLHVALSQRRRFNQIGFSKDYHWSHNDLLIALDMLRIQQQPINIYEGLSHLQELLSSVVYGGCVDEEEDLRVVQAMVHSLVLNWQDVEQMPASMGAASLIASLLPASQSQGRHSRTSSGTQARRLQRVFDTMKNEVQPAQLGLMSDTPGMMEIREGRYISSALQTLERCIIQKVPYSWQSTVSLLQSIKRDLEDLPPFDQPATESLSYLETFLSSEINLWKKTITAIQSEVGSLLQSAQGIIALPPVVEDTLLALSQDTVPKSWLPPGHPKCTGVLKWVDRLKSQALQLERYLWEGDRAVCFNLAMFANPRMFLRSVLQEHARKEFIEVHRLIIETQVMTLDEPPTTPPAKGVYITGLLLHNADWDTKRHLTILPHPPDPSVTFTHIPSPLPIIWFKPTVKSLASDVNEDNLTRSPGSYRCPVYMQGSEVTMLSTHVLLAFVELPSTLEESVWEQKRIFITPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XK97</accession>
    <name>A0A8B7XK97_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="2 13">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110973758</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="2 13"/>
    <dbReference type="RefSeq" id="XP_022080567.1">
        <property type="nucleotide sequence ID" value="XM_022224875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XK97"/>
    <dbReference type="GeneID" id="110973758"/>
    <dbReference type="KEGG" id="aplc:110973758"/>
    <dbReference type="CTD" id="5592"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12085">
        <property type="entry name" value="DD_cGKI-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000096">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000035">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031831">
        <property type="entry name" value="PKcGMP_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF111">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16808">
        <property type="entry name" value="PKcGMP_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0140">cGMP</keyword>
    <keyword evidence="10 13" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="206"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="324"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="462"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="721"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="736"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="102"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="468"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022080567.1"/>
        </source>
    </evidence>
    <sequence length="772" mass="86570" checksum="EB81D62D470C1DB4" modified="2022-01-19" version="1">MGSALVCHDQRSVVFPSSGQSVRSRGSQDSDAQSKDALLRHTPSHASSEFREGWIEPAKQSVVTEQNVHLVTGISLGNVGVSGPTDPPAAPLTPAGNSMGSLTELQKALRQKEERIRHLEDLLRQRDEQVTELQSKLDKFQSVLPTSPSLVNMMGRTPRNKRALGISAEPQALRSAKEMAAQEFKKYPKSKGARDCIKAAILDNDFMKNLELSQIQEIVDCMYPVEYSRDSCIIKEGDVGSLVYVLEDGKVEVTKDGKFLTTMGKCKVFGELAILYNCTRTATVKALTNTKLWAIDRPCFQAIMMKTSLVRQADIVELLHKVAIFQHFPEETLNKIADVVEETYYDDGDYIVRQGAVGDTMYIIQKGKCHVTQRPGSGGSPRLTNTLKKGDYFGEGSLDGRDEKRDANVIAAEKDGVVCLTLDRDSFLQVTGGPDSFISKNIEDSKNKKVDSEFADIRLQDIGVIATLGVGGFGRVELVRVNGRNQTYALKQLKKKHIVETRQQEHIMSEKKIMMEARCNFIVRLYRTFGDSKYLYMLLEACLGGELWTILRDKGSFDDSTTRFYTACVIEALSYLHNKGIVYRDLKPENILLDSQGYGKLVDFGFAKKINLGRKTWTFCGTPEYVAPEIILNKGHDFSADYWSLGILMFELLTGSPPFTGSDPMKTYNIILKGMDMIEFPRKITRNAANMIKKLCRDNPTERLGYQKNGLKDIQKHKWFDGFNWEGLKKRTLTPPIVPHVRSNSDTSNFDDYPPDTDPAPPDDMSGWDKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM51</accession>
    <name>A0A8B7XM51_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha-2,8-sialyltransferase 8B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110974121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081186.1">
        <property type="nucleotide sequence ID" value="XM_022225494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM51"/>
    <dbReference type="GeneID" id="110974121"/>
    <dbReference type="KEGG" id="aplc:110974121"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23963">
        <property type="entry name" value="GT29_ST8SIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF52">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-POLY-ALPHA-2, 8-SIALYLTRANSFERASE-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081186.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="43792" checksum="F126F3D383D80F3A" modified="2022-01-19" version="1">MPAVRRFWRTKRRLLAALCVLSTIIALCSLFPRMADIIGLTSRTTVEWRRMTAPQCKFVCSRSVDGVCVPLDLAIFVYKKDVPTKNMTFDLQNFNPVVSIPRKNNDTGKIGVLEVEQCSLEEHFPGVELIPRQGSCAVVGNGGILNNSSCGDFIDSHDFVIRANMAELKRFEVDVGRKTNLTVFNMQLLNQYSQAIFYSLFPWQRSVRDRFFDHIRSLNKSIIWYPKLLFRNRKMEKAGRQYHTIIETLRKFDYSDIRFAFSWKSISIERAYRLSKYGTLGFDSFAAARTFCSNITLFGFYPFYKDLEGRDVKYHYYDATTYNFGGEKENHDFHVEYRMLQDLEKQGQLKLVVRDCKPRNQTLLEKKFHRSLHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMB2</accession>
    <name>A0A8B7XMB2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">U4/U6 small nuclear ribonucleoprotein Prp3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pre-mRNA-splicing factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC110974538</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022081953.1">
        <property type="nucleotide sequence ID" value="XM_022226261.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081954.1">
        <property type="nucleotide sequence ID" value="XM_022226262.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081955.1">
        <property type="nucleotide sequence ID" value="XM_022226263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMB2"/>
    <dbReference type="GeneID" id="110974538"/>
    <dbReference type="KEGG" id="aplc:110974538"/>
    <dbReference type="OMA" id="NPQHRFK"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="10">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022081954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022081955.1"/>
        </source>
    </evidence>
    <sequence length="672" mass="75765" checksum="E245B399C469BAE4" modified="2022-01-19" version="1">MAALMGLSKRDLEELRPTVDDIVRKVLGFSEPSVTIAALNCVGKGMTKVKTVDLLKPLIEESAPKFVEKLFEAIERSQSSRDEHRAKKRSLRDDEGIDIKAKKSKSRFDSGNVVDGEPPAAEQWTPQQIKEMMASARMQIMAKRDQLPTKPQPQAPLITPTPTPTPPAASQVLMNEALDKARRAAEIQSRIQASMATAGLGQLVLQQALAGVNMKQAERMQAGDRPPAPVSKPTPLILNEKGVTVDAAGKEITLTHRVPTLKANIRAKRREEFKLNQAEKPQDAVSETSRFFDNSISQAPAQRSRRGFKFHDKGRFEQLAQRIRAKSQLEKLQSEIAQAAKKTGISSATKLALITPKKELKEGEIPDTEWWDTFILPRDSYRDCRQQVAGSSKGASEKYVGITNLVEHPIQMNPPAEITKTVNMPIYLTKKERKKLRRQTRREIQKELQEKVRLGLEPPPEPKVRMANLMRVLGNEAVQDPTKVEAHVRAQMAKRQRTHEEANAARKLTADQRKEKKVRKLKEDTSSGIHVSVYCIRDLSNPAKRFKIEANANQLHMTGMAISHKDVNVVVVEGGPKQQRKFERLMMHRIKWGEDKKRGDNDSDDSDNESESKVNKCSQVWQGMVQQRCFSELKFKQCPTESMAREQFRKHGVEHYWALAHGKRILEATANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMN8</accession>
    <name>A0A8B7XMN8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine-rich melanocyte differentiation-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081346.1">
        <property type="nucleotide sequence ID" value="XM_022225654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMN8"/>
    <dbReference type="GeneID" id="110974192"/>
    <dbReference type="KEGG" id="aplc:110974192"/>
    <dbReference type="CTD" id="83938"/>
    <dbReference type="OMA" id="KNPACPN"/>
    <dbReference type="OrthoDB" id="272149at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000793">
        <property type="entry name" value="Leucine rich melanocyte differentiation associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043313">
        <property type="entry name" value="LRMDA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282">
        <property type="entry name" value="LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46282:SF2">
        <property type="entry name" value="LEUCINE-RICH MELANOCYTE DIFFERENTIATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081346.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30402" checksum="B3BAD4E909E49744" modified="2022-01-19" version="1">MDSTKTYWLDQLRANRKNMANITLAENGERESLGPIVEGTQLSYLEHSATRIPDQLGQWYGKQVTRLDLSFNHIRSLEGLERFVKLEELILDQNELTDSVVLPHMSKLHTLVLNKNRIKDLESLMDQLKERCPNLTYLSLLGNEACPNELSSTDKDEDDYQRYRYYVVHRLPGLKFLDSRQVTQKERKEADRVGSYMRVVRVTADEDPHNSPDSPDGGHQSYNPLPDTTRPTDNHQGTFGKCRYVYYGRHSEGNRFIRNNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMT6</accession>
    <name>A0A8B7XMT6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Uncharacterized protein LOC110974170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110974170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081290.1">
        <property type="nucleotide sequence ID" value="XM_022225598.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081291.1">
        <property type="nucleotide sequence ID" value="XM_022225599.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974170"/>
    <dbReference type="KEGG" id="aplc:110974170"/>
    <dbReference type="OMA" id="MGRANNC"/>
    <dbReference type="OrthoDB" id="10069759at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37397:SF1">
        <property type="entry name" value="LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37397">
        <property type="entry name" value="SI:CH211-183D21.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665451" evidence="3">
        <location>
            <begin position="29"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2046"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="4">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="4">
        <location>
            <begin position="1725"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2131"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2146"/>
            <end position="2160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2161"/>
            <end position="2175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022081290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022081291.1"/>
        </source>
    </evidence>
    <sequence length="2175" mass="235304" checksum="D2A6D5813718EC40" modified="2022-01-19" version="1">MDKMQLGNGTLLVGLLLWAVCFVQLVSAGVVISELNADSLTRIDTREFIELYNSGDSQVSLADYVIVLYDGSTNAAYAVIPLQDRTLWPNTYFVIGSSFVSPVPDQTFSSSIDILQNGVDAVALYHGSSSLFTANMSVTADRLVDAVVYDNRGRDSSFLLDVLTPGQQVLDEMRQHLRREDESLSRCGGTDPLTLSQFRLTPITPGGPNNCTADETPIVMPTIPGGFPNLPSFPPDMANIYPDIAINEFSVDQGSGQFIELYDGGVGGIVLDGLIVVTYRGRNEASYRSPIVLDGQMTDENGYFLIGQASQQPQFELRWNLQTNRPPNAIALYFDDPSKFERNTPVTGVNLVDAVVYGDASNPEDSALVNILSPGRQPLVQPANQVNTSLSRCRSSERLRLEAFTSSIQTPGGDNMCTLPDIVINEVNVATENAQTNQFIEIFDGGIGQQPLDGIALVLYNGRTSLSYQAIDLTGYSTNVQGFCVVGWMNGTNVDIGLEFDVNVGFLQPGPDAIALHLSPPQRFRKGSFATNYNLIDAVVYGEGPALDLLHVLLPHQPILNEEGSSTSSGDRSISRCSCCQRLDSRSFGVGQASPGAINADCLQNNVTHVETIDHYMDLLRLNEIRIVQPGLPQGDFVELYDGGFGQIPLDNMVLVLYRTQGESSYRAIDLHNYQTDADGFFVIGPSSIQSSRLLISEIHWFDGNTGAVAIYKGSSADFPDGTLATSANLIDAVVYGDSNLLLLDLLTPGQSEVKYTVAAGETAILRCYSRNAFEVLAYAEGPPSPGMTNVCPPPPIVINEVNILDMSEAVGQYVELSSGGIPQFPLNDLLLFFWRGNPNRNPRLYNTVSIRSAHTDKNGFYLIGYRGLTSPRPDQTPFRVPTGKIREGSNGISLHRGLKSADHPKNSPPTTEGLVDVIIHGTDDAQTAQHLIEYFRPHAPRFQINEDASWSHRDESVNRCVDSQNNTVYQLAHITPKAPNHCPSRPDAGLIINELNLIPSEQFIELWDLGAGFTSLDDFVVVLYGEGDASYWTIPLTGFSTDSMGYFIMGTINVLPKAQFLFADGFMRHMYGAVALYRASTAASFPESGPPSSQGLIDAVVYTDLNSKPTGLTNVLTPSTASGFDSRTLQMSGFSLSRCLSPSLRSRRPFVLRPHTPRSLNDCPTYSNDVIINEVNVEHPGQATQEEFIELYDGGVGNVKMQYLSLVLFNGHYDDRSYATVDLHGKRTDLNGYFVIGAQDTERVNLKLRPRTSGGFLQDGPDAIALYRAPSGAFPQGTQATSRSLVDAIVYSTEDNSHISLVDKLLPGRSVVLEDANHATGDETINRCHGNQRLSPEVFSMGFPSPGRPNNCSRFSNSIYPDIVINEVNVEASGGAESAGEFIELTDKGRGMSSLDGFLLVLFNGANQDRSYWEMDLSGHRTNLNGFFVIGTSSVKPTPDILVPDDFIQNGPDAVVLYHTQARLFPRGTIATPLNMVDVIVYHTEASLTDDKTLLDKLAPGQRSVIEYSAYSDRDESLSRCLSNNSRTLSSFTVSQPTPGQPNICTGNPVIINEIKLDGDSVGFVELYDGGHGSTLLDSLSVKLYDSGGSGVRTYSVQSLNGKSTNGNGYFVYGKPSAEWNVDLEISTSDFLHSDVSSAVALYKDNDQTSAAVLLDAVVYGVENPSSMAVLDLLTPGQPQVQVSPDFGRGDASISRCACCVPLASVAFALTTPTPGQENRCLVGTSASTPSNVIISEVSPRNGGAESGEYVELRGPPGAHLDAFTLVLSSSSKTGPVYYYSLPLTRRVIPSDGIFVIGSGSVSPPVDALFPQSEEAVIRPGEGAVSIYRNSDSQFIQGTPVTSAGLVDAVVFTNVTEGSSSELSSILGFASIYARNFSAVADISAPSISRCACCNTQDPSAFTLSARTPGETNRCPRRAFKQTIQMHILDAAYEVWVTNPRFTDDLRRQIVAGVSAECKCSFNENYLKDEKLLNGSVYYQADMLALSKAHSKLLLDSYIHFVGKANQMNILGMDFHIDKKCFSDCLSGGGNSSKREKQKHQDVSAAVPVAVVIIVIVTIAVVAVMLYILYRRRQGGLSFMKNRGSGGDGSVAGDFRVTSSRALNDLDVLGTTSDNHNPTDFFANPVYMYEPPRAVTPQPGPPAKAEPKVESDRLAKDEGSSQANGESATVASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN03</accession>
    <name>A0A8B7XN03_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Scavenger receptor cysteine-rich domain-containing group B protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110974711</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082203.1">
        <property type="nucleotide sequence ID" value="XM_022226511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN03"/>
    <dbReference type="GeneID" id="110974711"/>
    <dbReference type="KEGG" id="aplc:110974711"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="49"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="161"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="274"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="466"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="299"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="312"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022082203.1"/>
        </source>
    </evidence>
    <sequence length="563" mass="60643" checksum="45B5DF6C213740D1" modified="2022-01-19" version="1">MDTRRKLLAIMGLMMSNTRGLRLGAFVTLSIAWASGLISGEINTDQNSIRLVNGSTVYQGRVEIYRNDTWGRICDSGWGMDDAYVACRQLGYGTAKNATGGTSFPPGGGLYWMDRVACDGEEESLAKCSFDGWGVISGCPLRDTAAGVVCQAYEPTDAVTIRLEGSSNSYEGRVQVFYSGAWGTICSDHWGLAEANVACGQLGFDGVQVATDAKTLFGADLTSPMYLSGLRCQGIETNLAQCARDSWLDDKCSSQDCDAGVVCISEDTPADGDLRLTGGSTASAGRLEIYHLGVWGTVCDDDWTENAATVACRELGYNGVEFALDHTDYGRHTGTIHLDNVHCTGRESRLTYCSHNGWGEHNCVHSEDVTLRCADESPDPAPPSTGTISLPMSSIIGIIIACSVIVSCALMIVRYLHYRQKISLTANRNNRVRALSRPDSANSFRYPIRGSSGLFLVNGMRVDPTLPPHGLEPPDYSSSPWKPPELPQEPPPSYEATVAHYPEARTDGVSSPVAPDYDATLLPNAVDFGQQPSPYQRRHGLGESVSSFEPTSTPPSSPMPPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPI2</accession>
    <name>A0A8B7XPI2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110974515</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110974515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081905.1">
        <property type="nucleotide sequence ID" value="XM_022226213.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081906.1">
        <property type="nucleotide sequence ID" value="XM_022226214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XPI2"/>
    <dbReference type="GeneID" id="110974515"/>
    <dbReference type="KEGG" id="aplc:110974515"/>
    <dbReference type="OMA" id="TVFTRCM"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665454" evidence="1">
        <location>
            <begin position="20"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022081906.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="32934" checksum="AAF85061FA8D6426" modified="2022-01-19" version="1">MTTRIILWGVPMCLSTVFTRCMNARGDTEIFMEPYDNCHSFGPERRISWPDQMRSAELLNDWQTYEYTQKLLEREDHYQASIVFAKDMAYAVEGKYDMLPKGYRHTFIVRDPVKVWVAYHRRIRQLLGDKIELRNGGDLPGDLESYASQTSVYKASFDLMEYTRTVLNQAPVIIDADDLTDHPEATLRRYCLAVGIPFKDKMLSFGSSGHSKDELDQRWHCSKFFTWGEERGGFYTKAMESKGFVSDKKEYKISDLPPEVVECVTRSKDWYEKLHALRLKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQS0</accession>
    <name>A0A8B7XQS0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leukocyte receptor cluster member 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110974789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082361.1">
        <property type="nucleotide sequence ID" value="XM_022226669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQS0"/>
    <dbReference type="GeneID" id="110974789"/>
    <dbReference type="KEGG" id="aplc:110974789"/>
    <dbReference type="OMA" id="VWRRDNI"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022082361.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41338" checksum="C4C2C6F6F022CECC" modified="2022-01-19" version="1">MNILPKKSWHVRSLRNIERVKRDEARAADENKQRQERAALAEQEARTALLRRKARQLTSSDDSPPSGSVQDDRLALRASLDQGIQSLHVDLFSDLGSEKPKGEKNKEHEKEEKAAKEQYEKKIGLLAYLGQSSAEAQTAKPWYFKPPDRVAKTAASEEQSCMDVKRKASLDPMVEMEKYLKVKRPKGETSVPPIKSTMKDVHVVTSRIQAGFQVGVDSDVKSQSKELNISKASSDDRRSKHRSHKSKHKHKHRRDKDKSGKSKERRDKHQSRGDSKTKDVRKDPSRGGREATQGPSVQQLREERLRREAAERARTNRLLSGEKPEGGAQRDLVEEVDRPGRYNSQFHPELARSRHRQAHYGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRK6</accession>
    <name>A0A8B7XRK6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Gastrula zinc finger protein XlCGF7.1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110974945</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082635.1">
        <property type="nucleotide sequence ID" value="XM_022226943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRK6"/>
    <dbReference type="GeneID" id="110974945"/>
    <dbReference type="KEGG" id="aplc:110974945"/>
    <dbReference type="OMA" id="FASKHAM"/>
    <dbReference type="OrthoDB" id="8113227at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000065">
        <property type="entry name" value="B-cell CLL/lymphoma 6, member B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000739">
        <property type="entry name" value="Zgc:171418 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000690">
        <property type="entry name" value="Zinc finger protein 354C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000925">
        <property type="entry name" value="Zinc finger protein 668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13913">
        <property type="entry name" value="zf-C2HC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022082635.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="36680" checksum="B1707DED730953F5" modified="2022-01-19" version="1">MDRVIVKEESDKTESDLPNEMSSYSDEQTPHKSHLHPSGGCEVGGSELMTKCDLKLHQLIHTGEKQYRCKTCNKLFVSERNLRRHKGIHTGEKPFRCQICGKAFHQAIQLTNHQAVHSLEKPFRCDTCGKCFGTKTSLRVHEVIHTEKGRVVCNICGKDFNKTYLWTHQQIHSNETNHSCKICGRGFTLRSHLKRHQESHIPLSDREKPYNCEICGKSYASLPGLKNHLQTHSGEKPFVCGVCGKAFSQKGNLSYHQHVHSDKKPFLCEICGRTFAVKSILQNHQLVHSERPQPPFVCKICNKSYKYAKRLTRHSQTHSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRW5</accession>
    <name>A0A8B7XRW5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110975003 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082740.1">
        <property type="nucleotide sequence ID" value="XM_022227048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRW5"/>
    <dbReference type="GeneID" id="110975003"/>
    <dbReference type="KEGG" id="aplc:110975003"/>
    <dbReference type="OMA" id="CGDDVRN"/>
    <dbReference type="OrthoDB" id="10440612at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022082740.1"/>
        </source>
    </evidence>
    <sequence length="836" mass="92131" checksum="8653978FED0F6105" modified="2022-01-19" version="1">MSTSETTERKGKYFKAVVNTPTAGLTKPKDGTTPRPLPVLQPRKYRPVDRAPGPPKTGPVPTGETTASVPGGDTDEVPTILGKLEEMTPGAKCGGAARCGDDVRNLTKLLFNRNLSGLLSGNNKLEDIAIIQTIFSANNVPQPEVMDVADPALSAHQRTPPQKEVSLSVSSAKPKPVSTTVSDHAQFGHSTGALVVTNRTYSPLSVQGKQRVVLMPMKSDGEDKPPPSSEKDTTGPAERRVVGRQRMVDMYPMRLPKLSVQQRETGNRSSCEMESGAQDQDTVCCGTTNLKRSRCRQQMSKSTGSTEATTHSTGKPVFYPGSRNLTLVRRRGHRTTPRAGSPMPSLRKPLPPIRRRHHSDICTVCPEVHDWKGLARNPRWYPTAKTEGGRQCPCVRQTDSVTRPSAEGQDDFVRDTEQEEKVEVEEDHEVQFGEDLEKGCEKPVKPAEEAEGKSNWFPERSIAVQESDVSVGDEAEKTKDESSGIEKSPECDAIVRAHSQWLTAGTSLLSGEKDDELHEPKTRIPVPDDSHLQRRLMMEGLDFECDSSTEITFEDDNTLLQAVLLRNHALNYGVVFESGDPNPSTEFKGQCSEKPDSRNQPVGKRKPKHFDDRNRILNTCAHLQGRHEADERTSEATHQGERWGCQMSVITPKSEVIMTSRGQQKVVNSSLVAVGRGQSLSNAKSGEECRCVHSEEVAKEDSSLETLLKREMNRYMHSLRHDTAREKHQKASTSAQNIPVKVQNLTAVSRPITADVSSGAAALTKAVGFIPSLSRNEYESLCRKTTVSQPARFLARAPLALPSITGNPSEMLRITRFNGEVKGMQLARQRERKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUK5</accession>
    <name>A0A8B7XUK5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110975954</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084533.1">
        <property type="nucleotide sequence ID" value="XM_022228841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUK5"/>
    <dbReference type="GeneID" id="110975954"/>
    <dbReference type="KEGG" id="aplc:110975954"/>
    <dbReference type="OMA" id="EVAFMIY"/>
    <dbReference type="OrthoDB" id="10057614at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35978">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35978:SF1">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084533.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="59681" checksum="DFC81A4A8B5006F9" modified="2022-01-19" version="1">MGSRSGSPMTAVLHTHLDNLEESGRLEAMMPNLLQQMRSHSQPSLSEDGPPEPPASIDGSWSDVQIGSSPRHHQLAPPQIEIQRPSSAPPSRTDSSPSPINSSRPSSAQLSRRPRSSTEKVPVLGGASHPSRQRSVSVAGLGKEWKGRPLPVFGGSKPVEEEEKAMQLAQEAKSSVNIRELFSGSAAKEYRKELERQEQERWEKQRRDSKQLNRFYKEHMMRQEVALVQRPDIMDRGWAREYLSDKMLKDRMRQEKWNEQMRQQALQNRKALSLLKRIGPSVDIWELFHGGKRGVTKAQMKKAAVTIQKYVRGWVVRTMLEKVKQKSRVHAGSFRAFVKYYAQLMKRIARWHGVKKPNIHLDLWQMDEFMDRKRYYEYVFAKRAHPNDFITIRDLEGFFKECDHYPSKREIFNAISGATKKDAEKLDAKLNEKEVTEVAFMIYVPQGSSLKTKDTRKSTWLNPLVDGKEAKKLMGSDEVEKAEYAKSLQVVFAAFQERQEKEAAAKRREKKQQEEAGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV68</accession>
    <name>A0A8B7XV68_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 2 subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 2 subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975617</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083915.1">
        <property type="nucleotide sequence ID" value="XM_022228223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XV68"/>
    <dbReference type="GeneID" id="110975617"/>
    <dbReference type="KEGG" id="aplc:110975617"/>
    <dbReference type="CTD" id="8894"/>
    <dbReference type="OMA" id="CMREGNK"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="7">
        <location>
            <begin position="197"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022083915.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37599" checksum="FBC465F391763BF3" modified="2022-01-19" version="1">MADDEAIFDPTMKKKKKKKKMPFDLEAALEGGGDTQESTEAPEKEEAPKNTEANEADKKTEDMDFDLDFSLKKKKKKKKTFDMDAMDDALAEVGNAVDGESQEATKESAPAETNDFDADLDFDLTKKKKKKKKPKLDDLGADTLDDSNKENEEKTELKDTSGTAWAGTERDYLYDELLTRVFDIIRAKNPDMVTGEKKRFIMRPPQVVRVGTKKTSFVNFTDICKMLHRPTEHLLAFLLAEMGASGSIDGNNQLIIKGRFQQKQVENILRRYIKEYVTCHTCRSSDTFLHKENRLFFLQCERCQSRCSVTSIKSGYQAVTAKRAQIRAKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWR1</accession>
    <name>A0A8B7XWR1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084256.1">
        <property type="nucleotide sequence ID" value="XM_022228564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWR1"/>
    <dbReference type="GeneID" id="110975783"/>
    <dbReference type="KEGG" id="aplc:110975783"/>
    <dbReference type="OMA" id="TLWENNW"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084256.1"/>
        </source>
    </evidence>
    <sequence length="83" mass="9735" checksum="C6A6708B6D3AC825" modified="2022-01-19" version="1">MADSKKQEKRAPEKKVDLGLLEEDDEFEEFPAEEWGSEEEDPTDSNVWEDNWDDDDVEDDFSKQLRAELEKQGSKDQPEPMKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXI3</accession>
    <name>A0A8B7XXI3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110976543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085594.1">
        <property type="nucleotide sequence ID" value="XM_022229902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXI3"/>
    <dbReference type="GeneID" id="110976543"/>
    <dbReference type="KEGG" id="aplc:110976543"/>
    <dbReference type="CTD" id="54584"/>
    <dbReference type="OMA" id="YQRQSMQ"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="308"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085594.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39164" checksum="24D8954A4195C0F2" modified="2022-01-19" version="1">MHFCQVHVGLMAHQPPHPPDPLFMLRGSKDAVNCVKFYPSADRKKGRLLSGCGCGEVRVWNLETRRADTILDGHDGKSVLWVQPLGNYQILSQGRDGHLLTWDIGQGRHNVTSRLPINGLTFCKCDIFHQGNGKGSPLVAAPGPDFEVCIVDVMSKTVICTLRTDKDVKRFGMPMCIKFIDASRLLVGYEAGQVALWDTNAQKILAHKQFHSEAVMCLDYSTVSERGVSGSADDKLVSWTHSEVSWIFTHQLTGYVSDTYLVILEMVAANNLHLINIQRVNFLVSLKWFLAFRIRLFGWKKLKPLAVLSSHRQTVNAVDFSDSLTAFNSAQLLAAGSKDKHISLWSLYNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0D3</accession>
    <name>A0A8B7Y0D3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein subunit beta-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976474</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085441.1">
        <property type="nucleotide sequence ID" value="XM_022229749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0D3"/>
    <dbReference type="GeneID" id="110976474"/>
    <dbReference type="KEGG" id="aplc:110976474"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085441.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37148" checksum="63D6CE2B51077F2B" modified="2022-01-19" version="1">MSELEQLRQEVDILKNQIRDARKAVNDSSLGTITSNMDSIGRIQMRTRRTLRGHLAKIYAMHWGSDSRNLVSASQDGKLIVWDSVSTNKVHAIPLRSSWVMTCAYAPSGSFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFINDNQIVTSSGDMSCGLWDIETGQQTTGFTGHTGDVMSLSVSNDNQTFVSGACDASAKLWDIREGNCKQTFTGHESDINAVTFFPSGTAFATGSDDATCRLFDIRADQELMLYSHDNIICGITSVAFSKSGRLLMAGYDDFNCNVWDSMKGERAGVLAGHDNRVSCLGVTDDGMAVCTGSWDSFLKVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y118</accession>
    <name>A0A8B7Y118_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette sub-family D member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110977228</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086859.1">
        <property type="nucleotide sequence ID" value="XM_022231167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y118"/>
    <dbReference type="GeneID" id="110977228"/>
    <dbReference type="KEGG" id="aplc:110977228"/>
    <dbReference type="CTD" id="5826"/>
    <dbReference type="OMA" id="KQFHDME"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF59">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER ABCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="41"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="424"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022086859.1"/>
        </source>
    </evidence>
    <sequence length="644" mass="73277" checksum="61C7363EEA39ABFE" modified="2022-01-19" version="1">MAILWRVQDSKAKKYRVDLLFIKRLAGIFRIFFPSLRSAHLALFLLLLLVSVGAEVAIYYVGLIPSEYNKVLPVKNLGGFIETTWKSMLYICLIALILSARTYISKMLYIHWREALSLFIHKLYFKNFHFYQLNVLKIDNIDNPDQRITQDVERLCNQFSSIVPLLIVSPFTITFYSYSAWAATGYIGPISIYLYFIVGTIINTFLMAPVVERTYRQEKLEGAYRFKHVQIRSNAEAAAFYVASHVEREKTNKKLKRLIDTQSNLINFDFWLQVSMNLFDYIGSILSYVAIAVPIFAGAYDKLDSDELYSLISKNSFVCMYLIHCFSQLIDLSNKVTEIAGYSHRIGELIESLKMLSDGDTQQHQDRDRSGAGGLITRIKYRSVQVPDRQGLLGDTKERTWHELQDSGDESGSEVSTPGDRVAYKLDQVSVATPDGKEVLIKDLSLEIRVGYNLLISGPTGSGKTSILRVLRGLFRTFAGTVAVDKGLTPDDVMFVPQKPFQTDGTLKEQVIYPQRISTLENPFDVDRKIMEILDRVGLLHLYERIGSLDKDVDWDWSDVLTPGEMQCLSFARLFYTKPSFAFLDEATSALTLQQQTRFYTHCKSLGITLISVGHRESLKHFHDAQLVVLGDGCWSLKDVVEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1Y0</accession>
    <name>A0A8B7Y1Y0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110976903</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086300.1">
        <property type="nucleotide sequence ID" value="XM_022230608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1Y0"/>
    <dbReference type="GeneID" id="110976903"/>
    <dbReference type="KEGG" id="aplc:110976903"/>
    <dbReference type="OMA" id="WEEERIS"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="165"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022086300.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="39577" checksum="42B00671EA7BA87A" modified="2022-01-19" version="1">MPSAKVKGKADEAGHQALSASGAACPGSQSLRQPRKRTRKNKAKKAAKKKMRNMKLPTRLARLLSYKAKRASLEVLQAESVQSNQTLQAGSTALTHCDKNVSPVVSSDRVKGFLEGCKNGCSSTFHKALACSSSHGENKSNGTFLGDINSRDGSSDGWRLIPKEKLIALDCEMVGVGPQGRTSALGRCSIVDYDCNILYDSYIKPELAIFHYRTPWSGIRKHHMVDAVPFREAQQQIAGILQGKILIGHALISDIQVLQLGHPWEDTRDTSMYKGLCELAGLTIGPGQHPSLKRLTKQLFGHSIQQGEHCSVEDARATMNLYKLVERQWEEERVSGFSDKGFRVSFMDDHFWPEDLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y211</accession>
    <name>A0A8B7Y211_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein 39-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086335.1">
        <property type="nucleotide sequence ID" value="XM_022230643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y211"/>
    <dbReference type="GeneID" id="110976929"/>
    <dbReference type="KEGG" id="aplc:110976929"/>
    <dbReference type="CTD" id="162517"/>
    <dbReference type="OMA" id="ELVFDPM"/>
    <dbReference type="OrthoDB" id="6421103at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22159">
        <property type="entry name" value="F-box_AtTIR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20872:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086335.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="54786" checksum="358CF94B0BD2AE63" modified="2022-01-19" version="1">MSETGQDHLVDVENEAGPSTESGVTHREHVDWSLLPDVTTTVIASYLLPWQRGYMAMVCSNWNRAIMKSPHLWRTKEFRLHGNWRDCHNLAYAKSVGRHLKRVYCSFGFRSHRYPRRMQKFFTALLAELYRSGPVQLLDLHVTSMQFHRNFQSPDTHHARKGIMRSLNRFLRRQTMLETLDLSEDLLRLDEGIALLSSVTENSSSTLKVLYIDDTFQQGAGVHADSSFARIMGRFTELVDVTINYSCMSAELLSRLATACSSALQVLNITTHRHDSHEHSIDREAWVDFSEALPGTHVTLSMSGIVRMVAVYRILTPGMPLTSLRVFGHNDGGFHPDRTLRYLSRHFQHSIRKIVVDVGPVYHPYGRGLHNLVQNCKKVENLQIHGRISWPVLRDVFDFVDETYIKKGLRPSLTYLRVVITTIGFGQEEALVMEEFRPTFDLHNLNYELVFDPMYPLPLGPLVPEADGQLVDDGIEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2S3</accession>
    <name>A0A8B7Y2S3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110977222 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110977222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086832.1">
        <property type="nucleotide sequence ID" value="XM_022231140.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977222"/>
    <dbReference type="KEGG" id="aplc:110977222"/>
    <dbReference type="OrthoDB" id="10063560at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="10"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1285"/>
            <end position="1295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086832.1"/>
        </source>
    </evidence>
    <sequence length="1338" mass="148148" checksum="6C0A28B90FD43A2D" modified="2022-01-19" version="1">MEEGESDPRTRTLDVTLRGGAPWGFSLKGGSEHRCPLTIARIEPGGKASQSGALQVDDIILSINNFECEAHTEAIHLVKRSPDTLQLIIQRSGSDLHLRQTMKQTDYSKSPPLQDLSPPAVKSPCIYDVAPSPPPQPYEKSGHIYDTKKSPDYDVHPSPKAAAGGVTRRMKKSETAKQPRPKSWHTADGSETWEDPGFRTSPKPVAQTLPQPAPQQAPHLHSPRLDPMEKLTVIETFHKRPLPHSNTHSMINLHDFKDEAEPGHGFVKRRVSEYIYSSNQELSSSRKDKDFYFVCSDKRESLTPFNPKFRDVNLQPAETYPKVAMATQIKSAQQKAYIGRVPGTQTPPESQPHTCSSSQVVSYSTVQMPERHYASTMKLTGKYCDENTLPHQQKPEPQVSPTSGHLVYRATPRMSPSPTFSDKREPPTPPQRGDSRNRTQQMSEQRKRPSWPLHAHKMQDNSGRPSSITLEAPPVKLSPQQDQPRPSLITGEPELLYTYSGEPHPDIPTSTSSVSQGELETVGSNTFPGMNRNRDKVDYLYTAVPLYVDPGSDDPETGINSFFPSSSPQNVPEKQSSLENQPRGSPPTRDSVDRITVDSDPLVAALESYMRTAVDHEEQLHGVNPEDSSTGSESPVHHPRSVSHGDHNRPQCQTQPMSITRNEGEKRLSRTSLSSLDSHSSSGHRVKSPTSRLSSDEEEQNRKNSQLGNANQRTWKNPNDFSSKKAEIDTEKHWQDIVRLANPNWGDKYQQSDLSTNSKSEGHVRTSSQIDEKLIRGNAPGIRSPISPLMMEAVTTIEPSKPETIIETQQKEIKFLKAEGRDSGYEVDSENPFRSQQESPVPHVTDTFSSDDWMKMGNMESTGGTSILSQLQKETPYSQHYMNGEPIVKPTANQKTANESSRQKVARSEASITQTRNSRPQPVCPPKSRDDFFKDVKGPTGQVVKDERSVCGSQPQLSRPGGSDSSSRHYHSSSLDLDTKATGAQLLAQPSFPPWKPESSNDSSSVFHTRSHSYSGGGYPSYSGPSEPRFSRIDEEQGVESSESVPSSQSTNRPDRRSAGGPLNRSHGSYDGEGRSHRRGDSDPNSGPFPVRKTSVESKGKADSDYRHGYSKSDSERHRKSSATDQWHKNSDPSGAISKPHRVSDSHENIREVLGKYVETKRNLLRSDGTVFGSNQGSLSGYGSMASLDQSSRFSSTTSLYGKPGWSMDSVDHSRQSSYSSQASHAHRDSGIVSPSESSWGPPSPNTSPPGAMDHRPRNQQRVLDHHHQRAASDSTHRTERVRDTNSLGRSSLSMSDEYRPTKKVSRSNSMIHSSRVRPQVTMTLGMDLGAVTTQARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3D4</accession>
    <name>A0A8B7Y3D4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein kinase PLK4</fullName>
            <ecNumber evidence="2">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Polo-like kinase 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">Serine/threonine-protein kinase SAK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110976976</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022086411.1">
        <property type="nucleotide sequence ID" value="XM_022230719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3D4"/>
    <dbReference type="GeneID" id="110976976"/>
    <dbReference type="KEGG" id="aplc:110976976"/>
    <dbReference type="OMA" id="NIVERCH"/>
    <dbReference type="OrthoDB" id="10004143at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13114">
        <property type="entry name" value="POLO_box_Plk4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13115">
        <property type="entry name" value="POLO_box_Plk4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13116">
        <property type="entry name" value="POLO_box_Plk4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000221">
        <property type="entry name" value="Putative serine/threonine-protein kinase PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000576">
        <property type="entry name" value="Serine/threonine-protein kinase PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.930:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.120:FF:000001">
        <property type="entry name" value="serine/threonine-protein kinase PLK4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047108">
        <property type="entry name" value="Plk4-like_POLO_box_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033699">
        <property type="entry name" value="POLO_box_Plk4_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033698">
        <property type="entry name" value="POLO_box_Plk4_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033696">
        <property type="entry name" value="POLO_box_Plk4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046437">
        <property type="entry name" value="Ser_Thr-PK_POLO_box_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18190">
        <property type="entry name" value="Plk4_PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18409">
        <property type="entry name" value="Plk4_PB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51984">
        <property type="entry name" value="CPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51985">
        <property type="entry name" value="CPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="33"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic POLO box 1 (CPB1)" evidence="21">
        <location>
            <begin position="724"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Cryptic POLO box 2 (CPB2)" evidence="22">
        <location>
            <begin position="839"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="20">
        <location>
            <begin position="1028"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="381"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="441"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="568"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="999"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="501"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="568"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="676"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="692"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="712"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022086411.1"/>
        </source>
    </evidence>
    <sequence length="1107" mass="123418" checksum="4A0A6F1F759502DA" modified="2022-01-19" version="1">MPVRTVHRLPSNLEYRMTSRSLNSGMGESIKDYQVMNLLGKGGFACVYSAKATNTGQEVAIKMIDKKMMQAAGMVGRVRNEVEIQCQLKHPSILELYSYFEDNNYVYLVLEMCHNGEMNRYLKTHNKVLTEEEARHCLKEIVLGMLYLHSHGILHRDLTLANILLTKDMHCKIADFGLAAKLNMPNEKHYTMCGTPNYISPEIATRSAHGLESDVWSLGCMLYTFLAGRPPFDTEAVKSTLNKVVLADYVMPEKISAEAKDLILKLLRKNPDERISLSGVLDHPFMTKSPLINHHMVQDGQTAKQRHIESSVDSGLATMATLSTATTFPSRLSSRSRPIKALPLPNLTPLVSQEEGLGGTKGHASDFNSCRVQEGYSEARWRGNQYDRHPPSPPVRDRAGFKKNSVCDDQSGSVSSTTSRQNSCMDSVGTEGYKHQLLQDAKSSYHSNHRSQSVDGNNKSSSFLAGVHHSQHSELSDWTDARHHRQAVPNSSQPNRTPLATRDDNGHEFGRHNMNDNHWTHVSDSSREHRSDRSSVDKSDRFCGKKGSNFRIGSSAFVGMGSKEHSASEEQLFLRKSSDPKQSEDAYRNKEYYKKRTGDLQTEPIEYRTNSLGSRDTKQDSDEKRMKWDSHQSHQGTTTGVKNHQTDCSPDQSGCLMYDAGKARHAKHRRKEDIENTNLQKSRPTPSTSLGDSHRREQSTSEVKRRHTQKHEKREQRDDNDGKSLVELTAPLNARRLRPIRQRTRNAVVSILDSGEVCLEFLKSKEGRDRVVEVCRISEDGMQITLYHPNGGKGFPVADAPPSPPQDHTTLYTYHDLPTKYWRKYQYAAKFVQLVRSKTPKVTLYTKEAKCMLMENSPGADFEACFYEGTKLHLLGHTLQITDSCSKATSVDVSDGYQAIPADTQTKVDHMHDVHRQCLELEAAIAGMESVKGHGPYFPIIICRKPTSSGASVMADKTIQNSKPGAPPVTTVTSPSVPPPVSASVCSYDGTVFSMKSEAPNTALSKPTHGSKASSKRVRDCSPPSQQNILKSTFVPNVGWASQMATGEMWVQYNDGTQIIVGASVLSVKFIDAQGNILQYGPTDKLPDSVKSKLAQLSAIIEMFVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3K2</accession>
    <name>A0A8B7Y3K2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Angiotensin-converting enzyme</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110977723</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12 13">Belongs to the peptidase M2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_022087764.1">
        <property type="nucleotide sequence ID" value="XM_022232072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3K2"/>
    <dbReference type="GeneID" id="110977723"/>
    <dbReference type="KEGG" id="aplc:110977723"/>
    <dbReference type="OMA" id="KWNERWW"/>
    <dbReference type="OrthoDB" id="10029630at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008241">
        <property type="term" value="F:peptidyl-dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06461">
        <property type="entry name" value="M2_ACE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001548">
        <property type="entry name" value="Peptidase_M2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10514:SF24">
        <property type="entry name" value="ANGIOTENSIN-CONVERTING ENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01401">
        <property type="entry name" value="Peptidase_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00791">
        <property type="entry name" value="PEPDIPTASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52011">
        <property type="entry name" value="PEPTIDASE_M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3 10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6 13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034427764" description="Angiotensin-converting enzyme" evidence="14">
        <location>
            <begin position="19"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 1" evidence="5">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor 2" evidence="7">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 1" evidence="5">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor 2" evidence="7">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="6">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine; partial" evidence="6">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 12">
        <location>
            <begin position="141"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10 12">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-10"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-11"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601548-8"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022087764.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="72797" checksum="DBEC3B756A36973C" modified="2022-01-19" version="1">MWSFALLCMVCMPVLSTAQGGHGHQELVADLAQAREFLDAYSETITELDYQATLAAWEFASNISDVNQQKQIEESLVLAAFVKEAGQNASRFDDSAFPDDVRRRLKNIRDIGTAILEPTKVAEFSELVSSMTDNYSTARVCRPGKPDECLQLEPGLTQVMASSRDWDELVWAWKGFRDKAGVPNKPLYARYVELSNEAARANGYPDTGSYWRSYYEVDDLVAQAYKLYNDILPLYKQLHAYVRRIMHKTHGDKVDVDGRIPSNLLGDMWGRFWGNIYKQVIPYPDTPDIDVTNTMIAKGFTPLRMFQLADDFFASCGLKRVNERFWNNSILEKPTDGRQIVCHPSAWDLGKYQDFRIKMCTEVNMEYFNIVHHEMGHVQYYLQYANLPPSFRAGANRAFHEAVGEVITLSVATPTHLSHPDIGLLNATMGGVDNQETDINFLLKTSLVTIGTLPFSLALEQWRWDVFAGDVEMDKWNERWWQLKHDLVGVRAPVKRTEQDFEAGAMFHIIIDYSFLRYFIRTVIQFQFHKGLCDAAGHTGPLHRCDIYKSTAAGERLANMLKLGSSKPWPDAMEAITGQRSMSADAINEYFAPLMTWLEETNRKNGETIGWDSGGTVPGISLTVLLACMLTTTYAVSTSLFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y518</accession>
    <name>A0A8B7Y518_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Uncharacterized protein LOC110977272 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110977272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086941.1">
        <property type="nucleotide sequence ID" value="XM_022231249.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086942.1">
        <property type="nucleotide sequence ID" value="XM_022231250.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977272"/>
    <dbReference type="KEGG" id="aplc:110977272"/>
    <dbReference type="OMA" id="WDYEERI"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040214">
        <property type="entry name" value="BRD10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056522">
        <property type="entry name" value="KIAA2026_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31095">
        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31095:SF3">
        <property type="entry name" value="RIKEN CDNA 9930021J03 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23450">
        <property type="entry name" value="KIAA2026_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="826"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1049"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1169"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1258"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1361"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1553"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1695"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2013"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2070"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1429"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="530"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="826"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="850"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="919"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1057"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1083"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1277"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1371"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1393"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1558"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1594"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1699"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2013"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2104"/>
            <end position="2129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022086941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086942.1"/>
        </source>
    </evidence>
    <sequence length="2129" mass="232783" checksum="DFBEA6E8F5A86B33" modified="2022-01-19" version="1">MFPDLSDELMQGYRILTEIFGDKCKSFVWPFLEPVDTETLWDYEIRIKHPMWLRKIESKFFKKEYQDITEFAADMRQMLENCYRYNGMKHQISKYAQTLECVFEQKLALLSRPLQEKTTLYVTSNGKYGDGSPNTVELSSGRLRRACTRLAARALEQASATPLAFHVGRELEQQEREEKRQKIVDRRDEILKERQDLLGWDKQLIGEAHWTYMKSLWEIPAIGHFLCLCQSVLELDEISFFELERSFAIPMESTMLRRIFTSLLSTPYQRTRLGKKPPMPYKVWEARLREWVRGWYIVLDKLRDPIKVYEKIGVPERFFEVLGPYFPLDKLQYHELTYYERVWVTKALCDQLFETQLSVRRCVLSQPVEELRPIVLGVDGEANSYIHFPHFCGADLRIYRQSKYPDLLKAAKRDKVKSEGREDREAEQDAPRPRKLRKTPALRKQIPRPKPVTVETPRSRPSRLRQKLTPTVHFGTYAESIISSTESEDVTSEFTEIEDDASDSQWECQTTPDQPGGKAEAVEGDEDTESEKPIEGDDREDLKVSRPTKENEMDALVREEKHQPSQDTGVMKREQITDESVVSAMRQGAVAKPDGIEPLCNGETSSIHSSTTSENASPEDPPKLLAKLETKEEIREESGTCHHPTSESGMRCQGTECNVIPEGSLKMEVGSEAATPSEGITASGEQNANNNSSQTLDAASELEPLIEPDKKPCDATSPTEGELHVPPSSPPPPHKEVLPVLGEFELVCDSMESLRELVDKFAPPENKNPPPTTGRKRKVASYIKQPVRRRCEKDLHEKLTNLLLELTPYEARLAKFALRNREKFKKEYESAKMEPETDQDIKDIWASEESSSESESEAESGSEEEDQAANDQDEEWDASTEGTMRLRKRTVKRTQGSATPDDGEEAEDGEPVQEEAAKKPKRPRPSGRRSPPHKNQLNTSLLQLIKNLSNDGLSDACRRLQTMIKRAEAARYQMAHKSKLDPASLSDCGDGQAVTALLNKLFWVNGKPPAVEGNVAKTVEELISTYPMFVHNLIFRNLKNSLSKMAKVAKSTGPDSSDQKDEPESKEENLAVESEPSKEVVQPASTDADTVSDPVNSSSRMETRSSASNTTLEGDPKWKSKEKRKEVMDDFTLAGLYTVLAQAKGILRERLATGLSELLPDYPNLQESVVKTEPKKDLGDSVNPDQPSSRSDTDKELLFKMLPKPSQYQKNSQLALQGSAHVKYMSSVDVAAVRNSTRPGSSLLVSVPTAKLPTVPNSWSDKELAKGASPARAPLATSGQAAPAASTSQIGDNVGAVPHGVYTIKVDASVWSQLQGKPQLQQQFVLQQIREMQRKQAESGSMTTSGVGLSNPAQAVTCIRSPPKAQAVPPKTSSETRTTSSPARNTARLPPATNISDLSSLQPIKLSKPARPKARNRGGLAEPVSNLSQKELIALLQQQQRQLELYRQQQQQKQQSQQKNGEPQQQQPLIQEQANQHFVLSASGELRPSTRSQQATGAAKAPIVLGVRHTAPSVEPSQISASSCHPITEPLPVTAQPTRLSTKTTVTASLKHPKMTVNPVSSQHCATVPSATTVPSQSRQSSPIVQRPPAPQNSTSSSVSPRGPSTRFHLVQTSSGTQFVVRTGPNQAPRLISLSSVGNSGSTVPVIMTGQNRQFVKQTSQAAALVVSTTNAATVSMSQTVQFVMQPGQVIRNAAPASVSRSQQQTIQGSGGPLLGQATGAAQPTDARQNPTQAALQANQDRTGRAVVAMTNQSVGMQGAVKAVLSQVSQTQNQAAPAAIQKPQLAVVKGAGDSKVVVASPKKVVRLVHPSHLSTAATFVPTTDPSQVGSMPIVVTKALPAAPQGVQVVAQTPARQQLVHLPVKSRPLDSAVAAAATQGSPSGSTTAIQEHLQQVILQQLAAGKLKLSPQTIPVSKIGHQVVQQPVQNQQKAGQVVNAVPIVLSQQASQLITKLQQSVPATIKTSPPAASSGTQLDQQLQASIQILNQARAAGQAPAVRLLAVGNAISQKNLPSQETQSLQPVNPASPVAGPLGPRSSHLVLAQPSVSSQVVGQALPSQIILPTALTDLLTPPSQTSLQTGAKRSLPMPPPLLDPKIPRLTAPVQASTAQAVPATTLSGLPPDTTQGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5S0</accession>
    <name>A0A8B7Y5S0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane protein 8A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110977399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087176.1">
        <property type="nucleotide sequence ID" value="XM_022231484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5S0"/>
    <dbReference type="GeneID" id="110977399"/>
    <dbReference type="KEGG" id="aplc:110977399"/>
    <dbReference type="OrthoDB" id="69646at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319">
        <property type="entry name" value="FIVE-SPAN TRANSMEMBRANE PROTEIN M83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="752"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="780"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="559"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022087176.1"/>
        </source>
    </evidence>
    <sequence length="834" mass="92948" checksum="83D64D174F9A2F68" modified="2022-01-19" version="1">MSRAHCRLAARSVYTRKQRRYTCELSILVTMSTQSLLSSLIRATILLPLFYVINGQPGYGEQLFGTFRLKAYGSFGDVTLFHVVMPPHCTTANWDISVLKDTLECPKTSVHLALQPGSLPVTNPYNTSFPPHINTQSQRNLNLFTMSSAQPVRITFWTPTAGDWYLVAFLPRGDNNKIEQQGLGGHTCRYFIQMGVAYWQAEDIKSLSTQTRTTVELATETNYTTAMYRFYVSPLTKYLTFSYQNCQVGSEFNQTEVSDPCPVALRVGPGALPSVRTPPVLCKSNTSCSVQFGEPLADTWYYVRLDLSSLDEPTSANLSLGVETQKCMEENIQVFPVSSEDMELRTLVLNSNASLIYSPVNPSDNGSAFLHPALEEKESEPESYPPASFTRGLYLSPLSPHPPPVLSNWCPPVLPLSSAQLGGASPFKKFIWNTPNATDGLPVSPDTPVVVKFELDLPQDIGGNLVIKADVANKKDLPGQAFVTLCLRQGGIPPLNGTNISCDPEDSLTFNSHSADAAFPWIVPFPAPGVWYLSLESWCKSGAGVVPCNDTAYVLLDIGLYGCIDNCGEYGSCHSAIDMGILYYYCKCSRGYQGWGCTDDSEAWSQAYFLTRVLLLTLSNLFFIFPFILALVRRHFVPAISFFCTLFFSSFYHSCDADSLCIMSYNTLQFCDFFSAFMSFFLTLIAMARLPVPLRHSLEILGAFGLALGTTYNRFSLWAAAVPVGVGMGVLLISWARRWYKRRRCYPTTKWRWLLFILPGTAIIITGLCLYAFLETSDNYQYVHSAWHVAMAIGVLFLLPPRERNDKQHYTHMSELVDINTLNSELVVQDDPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6C4</accession>
    <name>A0A8B7Y6C4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylcholine 2-acylhydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110977479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="6">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087351.1">
        <property type="nucleotide sequence ID" value="XM_022231659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6C4"/>
    <dbReference type="GeneID" id="110977479"/>
    <dbReference type="KEGG" id="aplc:110977479"/>
    <dbReference type="OMA" id="HASITCE"/>
    <dbReference type="OrthoDB" id="10069378at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF100">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034465429" description="Phosphatidylcholine 2-acylhydrolase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="10">
        <location>
            <begin position="39"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="91"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022087351.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="18950" checksum="6726256B1A506DAB" modified="2022-01-19" version="1">MGKLCFIVLFVSLPSTCVNLIEAGLPFNKRDQQDVSITNVGQMGKMTSCTTGLSLIESARAYTGYGCYCGLGGAGNPLDATDDCCYFHDKCYDQSPCSYRQTYTIRYQMTTSSCGSDDATVTCKTASDYPGYDGDEKECALTICNCDKDLAYCLAEARSTYNEAYRNWSNSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6X5</accession>
    <name>A0A8B7Y6X5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor SOX-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110978340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088964.1">
        <property type="nucleotide sequence ID" value="XM_022233272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6X5"/>
    <dbReference type="GeneID" id="110978340"/>
    <dbReference type="KEGG" id="aplc:110978340"/>
    <dbReference type="OMA" id="EQTHISN"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22029">
        <property type="entry name" value="HMG-box_SoxC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor SOX"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017386">
        <property type="entry name" value="SOX-12/11/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF323">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038098">
        <property type="entry name" value="SOX-12/11/4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="65"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="65"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022088964.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="42333" checksum="A773E7E2E3B25483" modified="2022-01-19" version="1">MVPQTQSLGLIGSSQSSGPSSPESSTSGSDLSMTGIDLGAILQQSTLDISEDICQTNWKANNGHIKRPMNAFMVWSQIERRKIMETQPEMHNAEISKRLGRRWKTLNDSQKSPYVEEAERLRLLHMQEYPDYKYRPRKKAKPANKQENPTRNGGVSKHKHSSKSKSKNSSRHHHNKADRVPKLKLTIDKKFRESIKASKAIDLGSTQLTPPAKVPSSPTGSTPDSPVDGRSMYEDYVDVCPKPQQHEAQQQQHQQRIAPIMIKQQHHHQLQQQQQQQQPQQPSTVPINNNSTHTDLNTAQANSQLAGLTEEFFPSTWPNFDLQDLGSLADDLSPLDSCSSNGSHFEFPDYMTPEVSEMIQGDWLDTSFASLISACTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y755</accession>
    <name>A0A8B7Y755_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">PTB domain-containing engulfment adapter protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC110978054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088392.1">
        <property type="nucleotide sequence ID" value="XM_022232700.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088393.1">
        <property type="nucleotide sequence ID" value="XM_022232701.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088394.1">
        <property type="nucleotide sequence ID" value="XM_022232702.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088395.1">
        <property type="nucleotide sequence ID" value="XM_022232703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y755"/>
    <dbReference type="GeneID" id="110978054"/>
    <dbReference type="KEGG" id="aplc:110978054"/>
    <dbReference type="CTD" id="51454"/>
    <dbReference type="OMA" id="FIINARW"/>
    <dbReference type="OrthoDB" id="10057585at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01273">
        <property type="entry name" value="PTB_CED-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF77">
        <property type="entry name" value="GULP PTB DOMAIN CONTAINING ENGULFMENT ADAPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="27"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022088392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022088393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022088394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022088395.1"/>
        </source>
    </evidence>
    <sequence length="466" mass="49500" checksum="8614A6F8E5FD7E71" modified="2022-01-19" version="1">MMNKKSSAKQTGKRWVHPPSSLTNGHVVYNVKLLGHMEVDQPKGAEVVREAVRKLKQDTQGLPRMMQFAKQLKRAEGEKPPKVELTISSMGVTIQDRQSKVRLETFPLHRISYCADDKQDKRICAFICKQEATNKNVCYVMDSEKCAEEITLTVGQAFDLAYQHFLQTTGKSIGSQVQALQKKVRELETENTQLRMRIVELEARQGQQPPPYSETNSATTAAAAGGGGTTAGLSQPTLLKDLMASPSQPPPLYQNTPPPAGAIPPLASPPTAAAATVGAQAVTPTSRTSDAATTNGVASGEIVQSPGIPREHPPSLGSRGRPRSFTVPACTATTPAPMGTSVTSRPRPHGLASPSSQSSAVPSLAPPPSLGRARRSTTGATPVSRQDSQGSNSSYDPFGQAPFNQPQTLGVARSNPFLSTASSGSSQDLDVQHFQELQEGFASGLTIGNADLSLADLDPLKNLSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7H8</accession>
    <name>A0A8B7Y7H8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neurotrypsin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110978104</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088507.1">
        <property type="nucleotide sequence ID" value="XM_022232815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7H8"/>
    <dbReference type="GeneID" id="110978104"/>
    <dbReference type="KEGG" id="aplc:110978104"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="69"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="164"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022088507.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="29541" checksum="FA9DE30D8BCD7A21" modified="2022-01-19" version="1">MSSVRALHSGPPYCSAHRHAINVTHICGSASSQIQICIHKKNDVGKCCGIYTIHGHPSYNAYHEDEHPVRLVGGDSETEGRVEILFNGQWGSVCSTGWDAADASVVCRQLGLYGQGTGHVLMENVACHGNESRLSDCAFPAWGSTCKNQHVASVSCQIAEDFPIRLAGGRTEQEGLLEVLFRGQWHVLFISRWTASASSVVCWELGLPGPNMSYTLLQRKEGQPTPRWVSLIDVSGNGNEEKLVDCATWSLGTNGANLYPLNYAVRVSCQIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y987</accession>
    <name>A0A8B7Y987_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Zinc transporter 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110978318</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088919.1">
        <property type="nucleotide sequence ID" value="XM_022233227.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088920.1">
        <property type="nucleotide sequence ID" value="XM_022233228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y987"/>
    <dbReference type="GeneID" id="110978318"/>
    <dbReference type="KEGG" id="aplc:110978318"/>
    <dbReference type="OMA" id="LTHGWHR"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF84">
        <property type="entry name" value="LD05335P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="48"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="263"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022088919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022088920.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39383" checksum="18FE4149682FE4EB" modified="2022-01-19" version="1">MGGSKRRDEMLIASNAEDENGYGSVDNANDTQRHLVRHQVLQRARNRLLVAAILSLVVMIAEIGGGYLADSLAVVTDAAHMLVDFLGFIIALLAICLARKQPSQRLTHGWHRAEILGALFSVLIIWVMTGVLIYFGVKRAMADRLQIDSNIMIITASIGLAINFVLGFILNFTCDGGSCKPTVAAFGATDTEHQSVNLRAATLHVIGDILQSLSILIAAIILYFRPDLTIIDPILTIIFSVFVFLTTCRLFRDIILILMEAKPPSIDYADARRRLVEIDGVEGVHSLRIWSLTSGVHVITVHLVIASLYDGEPVNARSILKEARHILETKYGVLYSTVQVEYSDDGMAFLCARTPGPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA47</accession>
    <name>A0A8B7YA47_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Apolipoprotein D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089427.1">
        <property type="nucleotide sequence ID" value="XM_022233735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YA47"/>
    <dbReference type="GeneID" id="110978613"/>
    <dbReference type="KEGG" id="aplc:110978613"/>
    <dbReference type="OMA" id="VPECKYL"/>
    <dbReference type="OrthoDB" id="565904at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19438">
        <property type="entry name" value="lipocalin_Blc-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000027">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022271">
        <property type="entry name" value="Lipocalin_ApoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047202">
        <property type="entry name" value="Lipocalin_Blc-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437:SF1">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37437">
        <property type="entry name" value="LIPOCALIN-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08212">
        <property type="entry name" value="Lipocalin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036893">
        <property type="entry name" value="Lipocalin_ApoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034413378" evidence="2">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="25"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022089427.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20656" checksum="9294470BDB6FAC8D" modified="2022-01-19" version="1">MLSLVILAVFVTSSSALGTVPELDPAMYLGRWYQMYTNGWTNLFSNLPNPQCVTATYGAINATYISVLNHNYNLEGQESSITGYAFVPDVREPGKLKVSLEGVPIVGDYWVFKLGPIVNNQYEYSLITDGEATMQLFVLARDPVEFNAKYDAEVQEYITLTGFTVGLKKYEPVPQVPECKYLPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA80</accession>
    <name>A0A8B7YA80_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110978151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088601.1">
        <property type="nucleotide sequence ID" value="XM_022232909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YA80"/>
    <dbReference type="GeneID" id="110978151"/>
    <dbReference type="KEGG" id="aplc:110978151"/>
    <dbReference type="CTD" id="51241"/>
    <dbReference type="OMA" id="FKYGVPF"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022088601.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="14164" checksum="A677A944860936DA" modified="2022-01-19" version="1">MAASMNKILDAVKKSRFLRFGVPMLVIVVGGSFGLKEFRTLRYEIIDRRKTVDLETDEKLNEYKKKDKITIEGEYKKLQNEDIDTWHNIRGPRPWEDSKEFQAMQRENTEKLLIKRDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAH4</accession>
    <name>A0A8B7YAH4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transmembrane protein 107</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090254.1">
        <property type="nucleotide sequence ID" value="XM_022234562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAH4"/>
    <dbReference type="GeneID" id="110979063"/>
    <dbReference type="KEGG" id="aplc:110979063"/>
    <dbReference type="CTD" id="84314"/>
    <dbReference type="OMA" id="WCCLELE"/>
    <dbReference type="OrthoDB" id="2114471at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029248">
        <property type="entry name" value="TMEM107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34341">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34341:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14995">
        <property type="entry name" value="TMEM107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022090254.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="15404" checksum="B0BC95A550301058" modified="2022-01-19" version="1">MAGLTHLIPARFLCIIAHMVVSITILWSRDANLKACLPASYSQEQYDSADRGFLAGLILSLIFIVMELAGFMSGVTIFVNMESLFSITAHSVGAVFLSYFLFEVWPCNTYWYMFGCCSAFPAVIDTGVIISKIFFNKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YB26</accession>
    <name>A0A8B7YB26_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 47-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110979174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090444.1">
        <property type="nucleotide sequence ID" value="XM_022234752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YB26"/>
    <dbReference type="GeneID" id="110979174"/>
    <dbReference type="KEGG" id="aplc:110979174"/>
    <dbReference type="CTD" id="57470"/>
    <dbReference type="OMA" id="YDVKPPT"/>
    <dbReference type="OrthoDB" id="67933at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="B3/B4 tRNA-binding" evidence="4">
        <location>
            <begin position="323"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="503"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022090444.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="63591" checksum="195EE54E2BD2D506" modified="2022-01-19" version="1">MYCYLLGCRYRSTRLYKMASLSWTEIVQAQKENRRELLLNGPQIAQRIVRSGLDRTLYSLELLNYLEIADASLPDLSEDIGKLVNLVNLVLRGNKLSTLPSAVGNLKVLRLLDVSSNVLKTLPDELGELSELHTLDASRNDLEGLPESIGKLHRLSVLNISSNKIESLEPLCTGQLLHLSELTGVKNAITVIPDTISHLQALKKLDLSSNKIAEAPASLADCTKLKDVLLTENPFRDRRLGKLVQQSRGTKATLDYIRTHGTKKSAPEEKPAKAKKKKGRKKAASTGSDLSEDLDKLMLRVLNFKDSSDGGVEVIVKEGVASVRPFIVCCILRDVNFQKGTRFKRFITAQNKLHDGPLCAKRTKATIATHDLSLVKFPLTYEVKEPAEIQITPLGRNKCTSADALMTQLRKEADDLRKESKRNTVSGIHKYLELLDGHQKYPCLCDREGQVISFPPITNADITKISRSSDHILIEVTSSTDLAVCKKVMDALLQRSAEILLDSPGTGTAASDDPDEDVNPGPADEAAAATDSAGGREVGGQRSLVVEQVRVSGVEGSLKVVYPSRTDLQDMTDIKVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCZ5</accession>
    <name>A0A8B7YCZ5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110979064</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasmic vesicle</location>
            <location evidence="1 12">COPI-coated vesicle membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="12">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090255.1">
        <property type="nucleotide sequence ID" value="XM_022234563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCZ5"/>
    <dbReference type="GeneID" id="110979064"/>
    <dbReference type="KEGG" id="aplc:110979064"/>
    <dbReference type="CTD" id="9276"/>
    <dbReference type="OMA" id="YVDYYPQ"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000008">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="181"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="319"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="594"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="856"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="865"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="880"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="899"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022090255.1"/>
        </source>
    </evidence>
    <sequence length="928" mass="104372" checksum="6F86F9C8F79196F4" modified="2022-01-19" version="1">MPLRLDIKRRLSARSDRVKCVDLHPTEPWMLASLYNGNVHVWNHESQTLVKSFEVCDLPVRAAKFVPRKNWVVAGSDDMQIRVFNYNTLERVHAFEAHSDYIRSICVHPTQPYILTSSDDMLIKLWDWDKKWNCAQVFDGHTHYVMQIVINPKDNNTFASASLDRTVKVWQLGSSTPNFTLEGHEKGVNCVDYYCGGDKPYLVSGADDRLVKIWDYQNKTCVQTLEGHAQNISCVSYHPELPIIMTGSEDGTVRIWHANTYRLETTLNYGMERVWTIANMKGSNNIALGYDEGSIIIKLGREEPAMSMDSSGKILWAKHAEIQQANLKTMGDLEIKDGERLPLAIKDMGSCDVYPQTVSHNPNGRFVVVCGDGEYIIYTAMALRNKSFGSALEFVWSHDSSEYATRESNTLVKIYKNFKEKKSFKPDFGAEGIYGGYLLGVRSSSGLAFYDWDSTELIRRIEIIPRQVYWSENGDLLCIATDESYFILKYSSEAVAKAQETNEGVTEDGVEEAFDVVGEIEEIVKTGLWVGDCFIYTNSLNRLNYYVGGEIVTISHLDRVMYLLGYIAKDNRLYLGDKELNIISYSVLLSVLEYQTAVMRRDFETADKVLPTVPREQRTRVAHFLEKQGFKSQALAVSCDPEHRFELALQLGELKIAYDLALESEAETKWKQLAELATTKCEFRLAQECLHKAQDFGGLLLLASCAGDADMVGKLADTADEKDKNNVGFLAYFMQGKLEECLALLCKSGRYPEAAFFARTYMPSKISEIVTSWKESLGKVNKKAADALADPTQYENLFVGLKEAFKGEEYLKATKKNYPARAYPKLPSNSDRDILDEMEEATASGTFSEDQVLPDEPEMAELEADQPAAAEPAATKQPPAADPPAAPPTKAPRPRTPDDDLDLDLDDLNIDDNLDTGDINLDDDFLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEY8</accession>
    <name>A0A8B7YEY8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">Exostosin-like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110979555</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091151.1">
        <property type="nucleotide sequence ID" value="XM_022235459.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091152.1">
        <property type="nucleotide sequence ID" value="XM_022235460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEY8"/>
    <dbReference type="GeneID" id="110979555"/>
    <dbReference type="KEGG" id="aplc:110979555"/>
    <dbReference type="OMA" id="CARYISK"/>
    <dbReference type="OrthoDB" id="5954868at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015338">
        <property type="entry name" value="GT64_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261">
        <property type="entry name" value="ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48261:SF4">
        <property type="entry name" value="EXOSTOSIN LIKE GLYCOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09258">
        <property type="entry name" value="Glyco_transf_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="11">
        <location>
            <begin position="179"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase 64" evidence="12">
        <location>
            <begin position="585"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022091151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022091152.1"/>
        </source>
    </evidence>
    <sequence length="840" mass="95468" checksum="61322A63546C577D" modified="2022-01-19" version="1">MQTMGVLRKGFASRKLYSFVLVVVVVFYLLVWHNGGWIVNRTRLAQSIRDGADVQDFTVCSSALDSTSPTSRRDEADLQMKLHQCARYISKLLTESEGIRSAVQEVDSFSKLQPWIQGNTCQNEVRQRFENGTHGGHPTNECRLSNCFDYSRCPLNSDFSVYLYQGLGKLSNGIEKVMTVNPYYTSDQNTACVFLVLVEGSSGNGLSPTKSVGASFSKLPSWKGTGQNHVLLNLARNVSSHNVLQTVSSSHAIVAQSNFEVSQFRPGFDIVTPMLLGTDATFDWHGTPRLTPAKRKYLLSFQGVQLPHRTSPFRDSIHDAIQSLKTVYRNQVYIDLSCPQILADRDFVYPSEWWMCDNNEKRAEILRQSTFALIIAPTDRILSSTMLQARLHEALRQNVVPVVLGEQVRLPFADFIAWEKAVIILPKARAKEMIHYLSSIHESDILALRRQGWFLWTTYLSSTEAVMNGILATLRTRLSLPPRPIPATPSQGLTRIDVGPTQKRSSSSTKYLRNSSYLSWAREPSWNSFPGPYHLYPSTPLEPVLPSDVYFEQAGKTFEPISKGTRKTGEAFRKSLGGNSPIEQFTVIIMTYDREPQLITLLSRLQGLPYMNKVLIVWNHPKPPSSYAKWPKQRVPMQIILQAKNSMNNRFLPFDEIETDAILFLDDDVHRLTHDEIDLAFRVWRENRDQIVGFPGRNHAMDVNNENFRYDAEKSCEVSMVLPQAAFLHKYYNYVYSYVMPQAIRDHVDKTMNCDDIALNFLVSFVSRKPPIKVGGHSDFPCVNCKSAISAHKSHYTKRTQCVRYFGEILGYTPLLYTQYQANSIMYGQGNKEPTCYKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHK9</accession>
    <name>A0A8B7YHK9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Interleukin-17C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091880.1">
        <property type="nucleotide sequence ID" value="XM_022236188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHK9"/>
    <dbReference type="GeneID" id="110979966"/>
    <dbReference type="KEGG" id="aplc:110979966"/>
    <dbReference type="OMA" id="MARISMT"/>
    <dbReference type="OrthoDB" id="6093351at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034521450" evidence="5">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022091880.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="19718" checksum="EC72836D49E32841" modified="2022-01-19" version="1">MARISMTAFLLGVLLFSFSSLAHSSPVRRDRDTSSSAGQCGQLTALELNTHLLGIQDDSSSFEPEFTVPTGSPTNAAPCPLNASIDASMAVNERGTCPWSYEREENRNRLPRVIYRAVKLCTKCLNPRTGAEIPDAVCEPINYTLKVMNRSECSNGNYTYQVGFQTIPVAFSCSRPVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIH9</accession>
    <name>A0A8B7YIH9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NXPE family member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092210.1">
        <property type="nucleotide sequence ID" value="XM_022236518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIH9"/>
    <dbReference type="GeneID" id="110980143"/>
    <dbReference type="KEGG" id="aplc:110980143"/>
    <dbReference type="OMA" id="RGRSEWH"/>
    <dbReference type="OrthoDB" id="5950832at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="2">
        <location>
            <begin position="350"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022092210.1"/>
        </source>
    </evidence>
    <sequence length="580" mass="65999" checksum="1B711E16D24A8517" modified="2022-01-19" version="1">MAEMKSNNILSEDFKDIINHGKNIWRRKPSMRDLLLWLVIVGMTYLMLAFFITGRVKLSHPKPSQRKFSARMRDERNIDSNAPAKLPIVTSPATTSNPTVARKSFFYIQYPKASYNVCDRLAIYIEVRDGNNKTKTRGGDFMWPYLQTVSLRASTPADKVIDHGNGSYTALFTLHWAGEIEPFVRLVLSSEEAYFVRSIRDRIPYRFAYDAKFTDGKTSEVTPCHITKDMYVDKAAKGLLFVKKAEVCDFSDPRTGSTWYCLKPKSLSCSHRSNHRGSPERGNSYLQQALLHKKVSLAKPEMLKNTGNVRTVKVMSKVSDSACLDLPHCNPGLPPKRADHSAGYYFKDLWKSKVCLASELQLKETIECLRNKHLFFIGDSTIRQWFWYLVSHTGQTMKEHITSTEAGVRRVYGHAFDNAHNITLDFRFHDYPLIGDWISTSVIYSAVDLIDSLPGGRDTVLGFTMCAHFTFTNLTYYLSRLEPIRDAIVRLQTRGTGKATVIIKSANTGTLQVTPVNTELLCYDLDLTMRAFFREVPNVTIIDVWDMTLSHRGGYNIHPSKLVVGEEVNLFLNFVCSKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YII8</accession>
    <name>A0A8B7YII8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Espin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10" type="primary">LOC110980238</name>
    </gene>
    <organism evidence="5 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092419.1">
        <property type="nucleotide sequence ID" value="XM_022236727.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092420.1">
        <property type="nucleotide sequence ID" value="XM_022236728.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092421.1">
        <property type="nucleotide sequence ID" value="XM_022236729.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092422.1">
        <property type="nucleotide sequence ID" value="XM_022236730.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092423.1">
        <property type="nucleotide sequence ID" value="XM_022236731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YII8"/>
    <dbReference type="GeneID" id="110980238"/>
    <dbReference type="KEGG" id="aplc:110980238"/>
    <dbReference type="OMA" id="HRAMENG"/>
    <dbReference type="OrthoDB" id="10261302at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022092419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022092421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022092422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022092423.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38587" checksum="AC1F0FDDB3DC4941" modified="2022-01-19" version="1">MPVHLAAHHDHLGCLELLLDCTPTERCYWRDKKTQGTPMHHAAAGGAVRCLRRLLKVENPDVTTKSGRTAVSLAAQAGSVSCLEALIDQAEADPQRADEDGMTPVHYAAQAGHLNCTHWLVRRARCSLNDSRKKDGATAMHLAAGKGRCPILQWALNRELSFGEELDVFGRTPVHYAAEEGQITVLRTFAKFPRVHLDVKDFLGRTPSNLAERRGHSACVRFLDACLQQRHPDGEGALFAKLTRSISSPGGLNNKLNRRNSNRRSGRRKHISSVYLEEKTLTDTESGSTRELPPTEEIATHIVSALISQVGMMSIAPVVPDVPLHRRIINNLVKKIKRQTSTEDFTVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJ14</accession>
    <name>A0A8B7YJ14_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110980330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092607.1">
        <property type="nucleotide sequence ID" value="XM_022236915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJ14"/>
    <dbReference type="GeneID" id="110980330"/>
    <dbReference type="KEGG" id="aplc:110980330"/>
    <dbReference type="CTD" id="8664"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022092607.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="64872" checksum="F4762CAA659E504A" modified="2022-01-19" version="1">MSAHFVPPVIQENPTGWGPCAVPEQFKDIPYQPFSKGDRLGKVSDWTGATYQDKRYLGKYSSQFGSGNQYTYYHDQDESSFQLVDTARAQKPIYLRNRMRFNQPRAATRRDRERREQRGQQVNMQTLTKAQKERQRQVRRLQKQYGKGRQKWTDKGNNRFWKASGPVKTRNASVQVRSEWEVLEELDFPRLNKLRYPDINESEDLFTCGEMEYYDKTFDRITTKSQRRLARVNRIFHKVTTTDDPIIRKLAGKGKVFATDIILATLMCCTRSVYSWDIIVQHVGGKLFFDKRDDPEFDLLTVNETAIETPQDEGNHMNSPRNLALEATFINHNFSQQCLKKNGEKYKFDKPNPFQEDDDSEVASVGYRYRKFNIGDDLDLIVRCEHDAVMMGSGGETQFISIKTLNEWDSKQLGIAEWRQKLDSQRGAVLATELKNNSFKLSKWTVCALLSGSDQIKFGYVSRLNPRDSSKHVILGSQQFKPVELASQITLNMENCWGILRCIVDKCFKLKEGKYLILKDPMKPVVRIYDIPDNTFSSDEEAEETSSEEDEDDDNGEDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJP5</accession>
    <name>A0A8B7YJP5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CCR4-NOT transcription complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CCR4-associated factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110980347</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="15">Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT2. Interacts with TIP120B and NANOS2. Interacts with EBF1. Interacts in an RNA-independent manner with BICC1 (via KH domains).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092640.1">
        <property type="nucleotide sequence ID" value="XM_022236948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJP5"/>
    <dbReference type="GeneID" id="110980347"/>
    <dbReference type="KEGG" id="aplc:110980347"/>
    <dbReference type="CTD" id="4849"/>
    <dbReference type="OMA" id="NHYPHAP"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000002">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
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    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="19">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
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    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="20">
        <location>
            <begin position="666"/>
            <end position="791"/>
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            <begin position="242"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
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    <feature type="region of interest" description="Disordered" evidence="18">
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            <begin position="580"/>
            <end position="605"/>
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    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="41"/>
            <end position="68"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="18">
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            <begin position="257"/>
            <end position="271"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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            <begin position="273"/>
            <end position="288"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
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            <begin position="289"/>
            <end position="310"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
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            <begin position="317"/>
            <end position="359"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="18">
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            <begin position="372"/>
            <end position="392"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="402"/>
            <end position="417"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00004201"/>
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            <dbReference type="ARBA" id="ARBA00007682"/>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="ARBA" id="ARBA00083548"/>
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            <dbReference type="ARBA" id="ARBA00093549"/>
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            <dbReference type="PIRNR" id="PIRNR005290"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
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            <dbReference type="Pfam" id="PF04153"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022092640.1"/>
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    </evidence>
    <sequence length="796" mass="90071" checksum="5E97C4E4D45B6AD3" modified="2022-01-19" version="1">MGDKRKLQGEIERCLKKVTEGVETFEDIWQKVHNATNSNQKEKYEADLKKEIKKLQRLRDQIKTWAASNEIKDKRTLLENRKLIEIQMERFKVVERETKTKAYSKEGLGLATKIDPIQKEKDDITMWLAHCIESLNIQVDQFESELENILSSSKKRKVPSDKQERVEELQSWLDKNRFHINKLETLMRMLDNSTIEVEQIKKIKDDVEYYIDSSQEPDFEENEFIYDDLDIDEESLSNTLLAASPDDDVMTNTSGDTPISSSPTLLPSPSSNHSKDKNEEDKKRRTDSESSSSPRKGGKSATSSSQSNRPTIVRAASTPSTTLVNSLPSSGVSSINQSNTNKSSLSKANSVPVPSTQHAIAQPPSGPAYAVAAGAQHNSSSSQASVVSTQGVRLAQEPPHTQPSTQVQTNNTQQPRPSLNGPHTAAFNMSSVENSIDHISKTVVSKSSVPSQPVPTAAVAPTTTPASTAPTPAQVTQQQQQQQSQQQSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKPLQTPVPEPVERVPTSQPVPVIAPTPKPSEPVMTNGPISPKAKEVSQCDLVTTSHYSSMPPRLLPPAGVSHQETNDTTEGEKEFKDYTVESRAIYESTSQAETSSPPMQEAIIPPSLGVAPLGPGIMTKDQLYQQTMMEAAFHHLPHPSDSERLRNYLPRNQCPTPPYHCQVMPPQMDSLDFFQRLSTESLFFIFYYQEGTKAQYLAAKALKRQSWRFHTKYMMWFQRHEEPKTITDEYELGTYIYFDYEKWSQRKKEGFTFEYRYLEDRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJU7</accession>
    <name>A0A8B7YJU7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26 27" type="primary">LOC110980494</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022092900.1">
        <property type="nucleotide sequence ID" value="XM_022237208.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092902.1">
        <property type="nucleotide sequence ID" value="XM_022237210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJU7"/>
    <dbReference type="GeneID" id="110980494"/>
    <dbReference type="KEGG" id="aplc:110980494"/>
    <dbReference type="OMA" id="NINTMFL"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="24">
        <location>
            <begin position="33"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022092900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022092902.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="55652" checksum="BDDC8871E28B6F83" modified="2022-01-19" version="1">MADRQTELTPILPAKTMSDRERARRRWVTVEPVVALAVVGYISIGLIRPFYLKGRLGESMFNITKQEEFSRCQANNSDGGTMEDEIQSQASLWILYLTTAMNIPIVVSSITLGTVSDRLGRKLCLVIPVIGYICQETVYVLTVHYKLPLPVLFVGEFLQGVTGGFGLLFAGCLSYISDISSENHRTMRIAVAEMLVFFVGGFVQVGAGYLLQDIGPIPPLAMALGFNVLCLIYITTPCILIETVDRENVPEHRKGIKDATRSVMNLFRFNENGRRWQMLLLDLFLFFVMLNINGVMSIFILYGTAKPFCWSAVTAGLAGSFGFVTGSLGMVVGTKLFSFCLGEYFIMQISCLSLLASNVVMSVAKTTLLIFVANGVGALRGMAVPIARSVLSKLVNPSEIGAAFAIVACMDNLSGFASSLMTPSIYAATVSYMSPAIFYVLSGLSFIPSGIVLILQIFWPRKKGYKLIEDSGIYEDSLGDDLKQEPNTCSYVNNPEPKTDEKESMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJV8</accession>
    <name>A0A8B7YJV8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Otoancorin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mesothelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093538.1">
        <property type="nucleotide sequence ID" value="XM_022237846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJV8"/>
    <dbReference type="GeneID" id="110980837"/>
    <dbReference type="KEGG" id="aplc:110980837"/>
    <dbReference type="OMA" id="TCEMIDN"/>
    <dbReference type="OrthoDB" id="8195838at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010335">
        <property type="entry name" value="Mesothelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026664">
        <property type="entry name" value="Stereocilin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048992">
        <property type="entry name" value="Stereocilin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412:SF17">
        <property type="entry name" value="OTOANCORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23412">
        <property type="entry name" value="STEREOCILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06060">
        <property type="entry name" value="Mesothelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21058">
        <property type="entry name" value="Stereocilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034479843" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="Stereocilin LRR" evidence="8">
        <location>
            <begin position="256"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022093538.1"/>
        </source>
    </evidence>
    <sequence length="1210" mass="132799" checksum="F243BC41DA2707E0" modified="2022-01-19" version="1">MMQLFQLSLLVVFLAGLKYLEIRALERDDQWRSPAATRGHEWHEAFDPKEHDTDVLDDSRLHEVAKAYGDFFVPDGSGRTDLNMSAVMYQAEKQQREAMAGGGLGRPAFIKQPILPNTVLKRISPDIIRNMTASEVFQLQKVTEMSYESLAHLLSNLQPQEFDKLIALARNATNFETKIPDPTIAKAVIDSCHRQWGPVSEWTTKQVSKIGPMLTSLNIEQVKQLNEEVLIEVIRTFARVGFRGPATRTLVLKAKRSWGAIRTWNPDQFATLGPLLIYLTPRDLKHIQPAQNVTSLLPLLGSLELERGQARAIISIAASSPDWRWTLEQVQSLGKMRQYLDPMELKAAPASAFASPELLEEMLPSNRRGHHRQTKEIARVLKESKGDVSAWGTEDFRSMGRAASGLGVSDLEQLDPSVVQGAIEDIADADYSPRQRKVLLRKYQRARGVQNTAMSAAEVRQMKGLAADLSTSDLAHMDPEDIRESVDVFAKNAKRMKKTQKREIIKQLKEAPGGIKDAIRDMGDMVKELPLKDLDNLCTANFTTMADQNSTSVAAAGLMNWTDGQSMKLFRCFKDEVLGSGEAEGADLPALPTPTTIRYLGSIARGMTCSDINGFVADDILPTVGSMMEQEGWSPRQLDCTHRKVRSSLSEAHSDYTADFTETEIASLTGQLLKEFSVVELDTIPSSHCEMLYSEISEEDLMGLKREKRKVLTSRALQCLGVDGELDTLEQDTMDVIGNLACDLDADALRRLSSSTFTDNLYSLQKCCLDVDQLVVVGERLVQELGSPNQWLSDTISDIGPLLVSLSELEIQSLEEDQFSLVAEDVMVRFAEYKDKWRRHCDIDLQPQDISSREEGFVSVAIKAKDALVAVSQADGSRRKRRESTYSPTCDEIESLGDGNIAWTVDELGAMSADTFDSCGYALGEVTGFTDAQLAALLNKAKEAWGQAADMTPDQISQLGHIASKFTPAEISQLNLTETDTVYAIAQYHIYTTDQLGAGVARFLELSGVSVASLDSLDLTALGNFLCGLTVVEMASIPSSAYQEAASTIGDLRSCDAGQWASLKAKAVEEYGAIDTWMPEVFAEVGSLVAGFTAEELSSLSDVSIAGIKPHAVSLIGPQTLAAGWSSSQLSKLDQLQAEAVTEEQLAALSEERRSALLDAEYGDDVSLAEMDEVTEEENDGTQGKSAGYQSTGLVPTIIAMCNVISTAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJZ3</accession>
    <name>A0A8B7YJZ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Uncharacterized protein LOC110980857</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC110980857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093569.1">
        <property type="nucleotide sequence ID" value="XM_022237877.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093570.1">
        <property type="nucleotide sequence ID" value="XM_022237878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJZ3"/>
    <dbReference type="GeneID" id="110980857"/>
    <dbReference type="KEGG" id="aplc:110980857"/>
    <dbReference type="OMA" id="EGNMVSY"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022093569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093570.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="45625" checksum="F72F013237F6D413" modified="2022-01-19" version="1">MQQILQPAIDLAEGGFTVQPVAANGWQYDADKLLRETNRHAQCLLKEGQRAPRAGETMHLPLLAKTFKALAVNGKAGFYEGRVAQAIVDVVRAHGGTLTLQDLKTHTSTLVEPICTDYKGLNVWEIPPSGQGITTLMGLNILEGLDLKGMGHNSAQYLHTLIEAIKLSFADSLWYCADTDQVDVPVNQLLSKDYAATRRNLIDPVRAREDFKNGEVKGGGDTVYLCVMDELGNACSFINSNYSHFGTGLVPEGCGFTLHNRGSNFSLQPGHPNVIGPGKRSFHTIIPAMVTDVKTGDLLSTFGVMGAFMQPQGQIQVLLSMSEFGMDPQRALDQPRLYVQVKQSGFTGNVCLEEGFGDDVIHELRSKGHNVVGPVKGWDRRVFGRGQVIARGNWFSATKPGGKSLHAGSDFRGDGEPVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK39</accession>
    <name>A0A8B7YK39_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase pellino homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110980525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pellino family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092982.1">
        <property type="nucleotide sequence ID" value="XM_022237290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK39"/>
    <dbReference type="GeneID" id="110980525"/>
    <dbReference type="KEGG" id="aplc:110980525"/>
    <dbReference type="OMA" id="QIGRMPC"/>
    <dbReference type="OrthoDB" id="8801906at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008592">
        <property type="term" value="P:regulation of Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006800">
        <property type="entry name" value="Pellino_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048334">
        <property type="entry name" value="Pellino_FHA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048335">
        <property type="entry name" value="Pellino_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PELLINO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12098:SF2">
        <property type="entry name" value="PROTEIN PELLINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04710">
        <property type="entry name" value="Pellino_FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20723">
        <property type="entry name" value="Pellino_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038886">
        <property type="entry name" value="Pellino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pellino FHA" evidence="3">
        <location>
            <begin position="46"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Pellino RING" evidence="4">
        <location>
            <begin position="307"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022092982.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="50347" checksum="0B92BD0CFDC6CFA4" modified="2022-01-19" version="1">MPLMKSEPEDTLEVSPNPKSLVQRVEIPANFQEIDTDAKNSSLGCSTVKYGELVILGYNGCLPSGNRGRRRSRFGLFKRETANGVKPDRQYEVGPQKGGQQSPKKGKHTIAYTLSRHQTVVVEYSSDSNTDMFQIGRSTEPVIDFVVMDTVPGAKSQEECTIAESTISRFACRIICDRDPPHAARIYAAGFNSSNNIFLGEKACKWKTEFGMDGLTTNGVLIMRPRGGFQSDARPGVWREVSVCGNIYSLRETRSSQQKGKLIDDENNILEDGTLIDLCGATLLWRSATGLLKTPTQKHLELLRQGINDTRPQCPIGFNTLVLPKHRHSSKILDENSKQPYAYLKCGHVHGYHQWDSKSTQQKTERTCPMCREAGSYEPLIMGNEPSFYVDSGNPTHAYVPCGHVCSEKTVKYWSQVPLPHGTHAFQAACPFCAMPLSGDTGYIKLIFQEAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKB7</accession>
    <name>A0A8B7YKB7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Golgin-45-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093708.1">
        <property type="nucleotide sequence ID" value="XM_022238016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKB7"/>
    <dbReference type="GeneID" id="110980937"/>
    <dbReference type="KEGG" id="aplc:110980937"/>
    <dbReference type="CTD" id="8548"/>
    <dbReference type="OMA" id="IRTHMMQ"/>
    <dbReference type="OrthoDB" id="5959043at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027095">
        <property type="entry name" value="Golgin-45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066">
        <property type="entry name" value="BASIC LEUCINE ZIPPER NUCLEAR FACTOR 1 BLZF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13066:SF2">
        <property type="entry name" value="GOLGIN-45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093708.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="44950" checksum="1BAB6ABCD5E27E91" modified="2022-01-19" version="1">MDQRNLDNIIFTHGQSINRDGTLPAFPRLEGDGKENAFSSSEPAGIPTAMPRLARPAFFDGKSRNSTDVALAERNRQRDIGPQSPGPLGSGCSVFGSGQRDVCAQLEEAIKEKEKLKKQLSRVETEVRELREDQTAMVSEAAVQNQVNKDLKKLLVASMGADLQAQLEHLSTERAQLAQDLENTIATLAEERETLERVNIQCDVWRSKFLGSRLQVDEAVSSRTRLNMVLQEACFALGKILEERDEIRTHMMQTQRLLHYLSNALQRTHSLSEDIKPSSNVLTLALLNEQVATIVSKHLLGDVGHSQDKTASQFDFVEWTSAEMLAKDILLNRQPALKLEQLHTFPSSASTTLMPPSSSSPPSATAAAATGLVTKTNMAHRFHPQTKYENLTINCCKYCTGDIKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKC8</accession>
    <name>A0A8B7YKC8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110980028</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091991.1">
        <property type="nucleotide sequence ID" value="XM_022236299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKC8"/>
    <dbReference type="GeneID" id="110980028"/>
    <dbReference type="KEGG" id="aplc:110980028"/>
    <dbReference type="CTD" id="5713"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000009">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00071765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022091991.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="38253" checksum="86D8D4FC9F12FB92" modified="2022-01-19" version="1">MPLPQLEINKVVVHPLVLLSVVDHFNRIRNQKRVVGVLLGAWRKGVLDVSNSFAVPFDEDDKDSTVWFLDHDYLESMYGMFKKVNAREKIVGWYHTGPKLHQNDIGINEVIRQYCPSSVLVIIDAKPKELGLPSEAYIAVEEVHDDGTPTSRTFEHVPSEMGAEEAEEVGVEHLLRDIKDTSVGSLSQRITGQLLGLKGFFSQMQHVQSYLEQVAAGKLPINHTIIYQLQDIFNLLPDVNLREFVRSFVVTTNDQMLVIYLASLIRSVIALHNLISNKVQNRDLERQEGKPEAKDKKEKGQGDKDKSEKDKDDKDKTDKAGGKETPSKEDKKSATGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKS2</accession>
    <name>A0A8B7YKS2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Nose resistant to fluoxetine protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC110980096</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092124.1">
        <property type="nucleotide sequence ID" value="XM_022236432.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092125.1">
        <property type="nucleotide sequence ID" value="XM_022236433.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092126.1">
        <property type="nucleotide sequence ID" value="XM_022236434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKS2"/>
    <dbReference type="GeneID" id="110980096"/>
    <dbReference type="KEGG" id="aplc:110980096"/>
    <dbReference type="OMA" id="ERNECED"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665582" evidence="2">
        <location>
            <begin position="24"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022092124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022092125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092126.1"/>
        </source>
    </evidence>
    <sequence length="734" mass="83154" checksum="C39B60B59DAA8E2E" modified="2022-01-19" version="1">MDLSGPVVFSWLASMLCVINVSCSNDFVTMKNQSLGERLKPVLEMFSHGLHQANLSQPEAPVSDKSYSLCLADLYKLGSNFKALDAFGKPDAGLYEGDAVWLGNYDECLSIVGFNYCLANLLINATKLGVKGVPIIDIRWGLCTPVSCSNEDLMRALQYFQGRLELKYPELEAVTPKSVICSQSPPISYNAGVICTIVLLSVLGGLMIIGSLYDEWLQFDTKKLKRHGRWLYCALISTVEDISSEDDDQTDDDYYDDVEPLYGQEASRQWNIQGEAKQESLLVRFFLCFAVTRNLSKLLDTRQKDTSIGSLNGIRVISMTWVILGHTLFFSLIYYTTQNGAVVYEWSKDFGFQAILNAFFAVDSFFFLSGLLVSFLTLSRMQELRSVKAWVWFYFHRYWRLTPVLGLTILVWMFIQPFFGDSPVWYTNTARTSCEKYWWTTLLYINNFYPQGFASQCVGWAWYLANDMQFFIISPFLLAPLFYAPVIGWIALVSLSIVCMAATVAIMVSYDASVDLIGMVQSQSNGYGLDDNSLVYEKPYCRIGPYLVGIGLGFIMHRIGNRKVKMSPFIALTGWLVAAGIAISVLYGLYPTYHKPEVAMSRAGEVAYGTLSRYAWGVALAWVTFACKYGYGGWINNFLSWTFWVPLARLTYSAYLFHPIVLMTFYLNFGTPIYESRYLMAYFFAGNLLLSYVIALFVALAVEYPFAALEKLFMPNNPKEKIESYHRNQQNLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKS3</accession>
    <name>A0A8B7YKS3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24 25" type="primary">LOC110981025</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.86" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022093863.1">
        <property type="nucleotide sequence ID" value="XM_022238171.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093864.1">
        <property type="nucleotide sequence ID" value="XM_022238172.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981025"/>
    <dbReference type="KEGG" id="aplc:110981025"/>
    <dbReference type="OMA" id="MTHESKS"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of signal transduction"/>
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        <property type="entry name" value="phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1"/>
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        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2_SHIP1-2_2nd"/>
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        <property type="entry name" value="C2_SHIP1-2_first"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
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        <property type="entry name" value="IPPc"/>
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        <property type="entry name" value="SAM/pointed_sf"/>
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        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46051:SF1">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE-RELATED PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46051">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24147">
        <property type="entry name" value="C2_SHIP1-2_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24150">
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    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00017">
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        <property type="entry name" value="SH2DOMAIN"/>
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    </dbReference>
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        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="21">
        <location>
            <begin position="14"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="22">
        <location>
            <begin position="1219"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="935"/>
            <end position="1064"/>
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            <begin position="1125"/>
            <end position="1144"/>
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    </feature>
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            <begin position="1191"/>
            <end position="1213"/>
        </location>
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            <begin position="201"/>
            <end position="261"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
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            <begin position="116"/>
            <end position="133"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
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            <begin position="1024"/>
            <end position="1034"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1042"/>
            <end position="1052"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022093863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022093864.1"/>
        </source>
    </evidence>
    <sequence length="1284" mass="142842" checksum="90C662060EE2B11C" modified="2022-01-19" version="1">MSIPAPGAPLAYPWYHGSITRLQTEECLMRANRTGSFLVRDSESFKGAYVLSVLCEGRIYQYRILPDGNGYLIKSSDATKQHTFSNVPELIQSYSITNNGLCCPLRYPTEAPKVETEEEQDSDDEPTEEEESDSFSMASPTDIALHTLRSRLEYLDQTALDGQFLEKLRDYMSSKAKQDYEDVKAGATTAGHLRQLVLSSARELTKQLDLFLAKMKALQQLFELSSVPSKTSSANETGNDLKQLFSRLGECQARVTSLENKAVATYLELSKGEVRIPVTPAKPQQASTEAPEKEPELPEMEPDPLIGGADNTYTGGLTTSDGISGGDTLKVHTLPNLTMSVTPFEVKVEGLTVGALKNTKVKLTVDVAHGTLSILKHFGKDMKEEMTSYTHDKIVQLIKSRGTNTKLQIRFSNGKKKEYSFEDAKKRETFCQLIQYMKMSHSYSKEVDQISVFIGTWNMGAAMPPTNITSWLTCQGQGKTRDPSMAAMPHDIYVIGTQEFKSAAINDKDWISRVKMEIGQLNGLNKKEYVTAATASLWGLRLAVLVNKDHEHQISHVRDSFVRTGIANTLGNKGAVGVSLLFSGTSFCFINAHLTSGTEKCTRRNNNYHDIIRGLSLSSKGMSLFDLTNQFHHIFFLGDLNYRIEWNVPEILRNIAYMNYADLFKHEQLKREKDKGNIFVDFSEEDISFPPTYRYKLGDRTSYDYKKIKKTMVRINEPSWCDRVIWRSYPGTHIVNTTYGCTTDITTSDHSPVFATFDVGIAATTVIPKGGSAQNAEIVFTSAEAIITTSMCGMFYLEFISSCLEAGSGKSEMNRTCTQEQMGSKMACIKPSWSSEELPKLTPILSDFDYLEEQHILMAIKSSDSEESYGEFVVSLKDKISSTPVPFHAVLTHQGHRTGEISGALHVKARDESLYDGSRKTKTYELVLFEDKEKGDGLPSAADAKGKTKKASAPKIPGIESPPTDITDALLHPVNRRHRQNGESMTVKASPETTPIGVKGEDTDGVPPPLPPPRRGASPVTPDVIQSNELTTRQLKPPKQLSLETSLTSDMSKPSLRACLSNPGDREPWDTTLILTRAKSPLAGCWDNHLPRLERPLPIPPPPEIHDCPPRADPALRSPPALQAITRGIPKKPARKQSPGKVRQLRAQFEKSNHNEEGSPENAKIFLEEGGKPPLPQRMGEVRPSEDILIEGLPPPLPAKSKTPPKSQMSDMEEYEVLRRPSTIMEWLMNLGLPQYGHQLLNSGWDSVTYLDGITDRDLLECQIDSKEHRLRMLDSIKNMPIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLE3</accession>
    <name>A0A8B7YLE3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger and SCAN domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110981123</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094084.1">
        <property type="nucleotide sequence ID" value="XM_022238392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLE3"/>
    <dbReference type="GeneID" id="110981123"/>
    <dbReference type="KEGG" id="aplc:110981123"/>
    <dbReference type="OMA" id="TITVLHH"/>
    <dbReference type="OrthoDB" id="10067983at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000075">
        <property type="entry name" value="Putative zinc finger protein 536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000448">
        <property type="entry name" value="RE1-silencing transcription factor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF64">
        <property type="entry name" value="LINKING IMMUNITY AND METABOLISM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="519"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="634"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="360"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022094084.1"/>
        </source>
    </evidence>
    <sequence length="795" mass="85941" checksum="ACF76674FC356A3B" modified="2022-01-19" version="1">MASAQKKTNVNTILIQGPGLEGGVITAATTTHLQGEIPQQNLQSPLKTTGSVPVNISIVPVIAADPIPGVQPAAVSPARPPCQPVATAGGTGSGAGSVSTTPPLAPLALKQITLLKTQQPSPEQMKSFDSFREHMDVFLVEVYRCKLCKFHSALKAVMAQHMTEKHFPVTGAGKGMTPDQPQAGYDGISETGDKQVTLPPAVVTMTMSSSEMQNPPFASQTFTAGNTVPSIIATVTAERLSLSSNAASEVTPVPSGTDNSVPIQVEVTSEMKRTSAEGNALELLMGIGHENEQDTAKCQQTAAGSETTERHVTNSASLTEVANGRSGSLIQDAGVTAAMEIDASERGGLVTVNEEELAQTLQIDKKTDSDDESENDDDGGVEDEDSDEGSKQDNQEDSSEEAALLKPVPIQIGLGPGAGDIDIQEIANTASKSNPKATTITVLHHGRGNGPPTAIQFKKSRKSKAVIPTGESLGIASPFTGRSYKGHKLFVCTTCHARYKTLTELERHVKKKHQRARKFLCEICGEALATRASVKYHVSKKHEQVRPVFHCSHCDYSTPFKARMAIHQATHQSEFFCSLCKKSYVSAERLNRHYSSPLHKNALNPLVCEHCGYSTKKRDNFLVHMRKHTGEKPYKCKLCSYASADGSTLKKHVMAKHSTIRPFKCQVCSFSCVDKKGLDIHSRKHTGERPFKCPFCLYAAKRRCALNIHLQTHSKEETADKQPKAQVTRYETVSTLAQDSPQQTLQPEQQYTTMTDYQPATLVTSVVPVVTQTAGEQSLVSGCEDKPVETVWQSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YM21</accession>
    <name>A0A8B7YM21_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">ATP-binding cassette sub-family A member 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC110980279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092521.1">
        <property type="nucleotide sequence ID" value="XM_022236829.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092522.1">
        <property type="nucleotide sequence ID" value="XM_022236830.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092523.1">
        <property type="nucleotide sequence ID" value="XM_022236831.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980279"/>
    <dbReference type="KEGG" id="aplc:110980279"/>
    <dbReference type="OMA" id="YFTIVAP"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000933">
        <property type="entry name" value="ABC transporter A family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF209">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="896"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1064"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1107"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1148"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1185"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1212"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1254"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="496"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1346"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1684"/>
            <end position="1722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022092521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022092522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022092523.1"/>
        </source>
    </evidence>
    <sequence length="1722" mass="190568" checksum="06F95D3FA43150DB" modified="2022-01-19" version="1">MMASFWRQTYYLTYRNFLLKIRMKQLLSQEIFLPIILVSSILIVNLTNKPRIYNEAPYGAFSNYPLLDANSSVSFMPDDSKPWAFTPNNSDTWEVMQRIKSALGERAPSVFLSFPDEEQMVTAYRSQPEPQFSIGIVFGADFPQNLMVALRMPFEAMPPTDENSRFASQASCRAIDGQPPGLASYNCPANRYLFSGFAVLQTVMQNAISSMLTNETLSLPDVSVRMFPKDRYVEASSFPRVFSSIYYVLMYTIFVAALLSIIVSEKEKKIKETMLVMGMSNGPFWLAWFITYSVIMLFVALVIALLSKYAIQNVANGNFLIIFLIMYLYGMSIICIAFMLTPFFNKATVAGAIGSLLTFLLSLIYLPLGLIANVPSVYKWLVSFFSPAAMALAIDQAATLDEGGAGIQFDNMGLDGFPPYVAMLAIDCVIYLLLAFYFDNVVPGTYGQRKPLGFCCMPSYWQNRQGEAEGMVDLNTLEDVPDVELVPQEMKDRAGIRIRSLSKTFKGGKEKQDVLAVKGVSLDIYEGQITCLLGHNGAGKTTLINTLTGLIAADSGQATIYGYSIRDPIQMQKIRSMVGVCPQENTLFENLSPREHLKVYAGLKGVPTEDIEEQVMKILKLTLLDQSENTQSKDLSGGQKRKLCVGIALIGDPKILFLDEPSSGMDPYSRRQLWNLLKSQRQGRIMVLTTHFMDEADILADRKAVMSQGNLRCYGSSLFLKNRFGIGYHLGMVVEPDVDVDRITQLVTAQVPNGQMSRSHGMELAYTLPLEDTSKFPDLFRAFEETSGQDGATVAKQLGIQSYGVSMTTLEEVFLKLNDEEMEDTEENEIQNATDTTPLAVNSLNGNYQSMAVGSSESVSLNVEHLITAPLEPNKYQLRGLCILLFKQMIRDPGTYFSRVFFPIIYIVLSVVLSSTISFGIGQVDNPSSLTLDPSLYLQTDSPSTLPLLSPLLYQNNLTVAGDIQPLLNQLDRLGLKVSNIPDMSNLSSVAPHSMATIVNSLGPPGDFLALYNDTAQHSLPILLSVLGNVLVALETPTETLLNLTFANHPLPSRAMSYSFNSGFFLVLFLAMAICFVPIGYCTNIVKERQEKVRTQLRVSGVKASNYWCSHLLIDTVQVYFITVVAAIIILIISAATGGSSLATGGGMFMFFIFMIIYSPLLVLFSYCVAFLFDDYKTCQSASQLIFFYGAIILAVPTLVLDFSAYNIPAAAIHLVFSILFPPYTIFGFLYYIDKVYQVAVFSQTLDELSFGDYFNFDTLIVPTLFCLLVSHVCIFFLLRFLEIQSTGGNLKDTFFFSEGKVGHVIANSDHIPDEDSDVRSEREKVEGMFNQGHHPEKCAVAVCGIRKEFQKRSGGCCKKQDSTGPINVAVRNLTLSVNEGEVFGLLGPNGAGKTTSMNVITANTGATKGQVQIAGYGITSSLSEAFHVMGFCPQHDPLYENITMREHIELYGLLKGIQPSDIEAIANHYMDGLKISEHADKRAQKLSGGTKRKLCFALSMLGRPKIVLMDEPSTGMDPTSKRFVWNTIISSFRDNRGAILTTHSMEEADAVCSRVGIMVSGQLQCLGTTQHLKGKYGGGYVLEIKLNPGPDYYSMDHTSGQATRLLEEMMSALDRKIKEVFPSAEAIERFGERVTYRVPSEVAISLSTVFAALEEGKETLHVEEYSFSQATLEQVFIEFAKMQRDDDEEPDAPSSPQRMLSRISVKSGGHSNPAATVTEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YM31</accession>
    <name>A0A8B7YM31_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol dehydrogenase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093717.1">
        <property type="nucleotide sequence ID" value="XM_022238025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YM31"/>
    <dbReference type="GeneID" id="110980940"/>
    <dbReference type="KEGG" id="aplc:110980940"/>
    <dbReference type="OMA" id="DERGCNV"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093717.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="41184" checksum="DA8B8BC4DFBA1FE4" modified="2022-01-19" version="1">MAVDKYTHFYAWTILSLAALAVYWAEDSVAAKFIAGVLALAGLYIGSKLMPRGRVHPEGKVVFITGCDTGFGNGLARRLDGCGFTVYAGCYTPDGPGAQRLVRESSGRLTIVPCDVTSGESVAAARDTVKAGLQRQGSVSTFVFILSELFAVVNNAGIWRWGPVEWTPVKQYKEVAEVNVYGMIRVTQAFLPLIRKAKGRFVNVSSVNGLWTGPCVSSYHMTKYAVESFTDALRREMNPWGVKVVLIEPGEYGKLTNIALHSRESLLAISNPLWDGASADVQRDYGRGYFEGYVARLHQAREDCWDDVTPVLDAMLDAVASRRPKHRYIIGELSTYCTVYKFILLPSWLTDGTFYKQDTLYPKPAACREKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMQ7</accession>
    <name>A0A8B7YMQ7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">ZZ-type zinc finger-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110981063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093942.1">
        <property type="nucleotide sequence ID" value="XM_022238250.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093944.1">
        <property type="nucleotide sequence ID" value="XM_022238252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMQ7"/>
    <dbReference type="GeneID" id="110981063"/>
    <dbReference type="KEGG" id="aplc:110981063"/>
    <dbReference type="OMA" id="CNFSSKH"/>
    <dbReference type="OrthoDB" id="20473at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="794"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="802"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="955"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="737"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="758"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022093942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022093944.1"/>
        </source>
    </evidence>
    <sequence length="1046" mass="115035" checksum="6992D72878D820A1" modified="2022-01-19" version="1">MSMRRQSRVSSHASLPENKSEAAFNERSTRSRTSSEDLVVLELPRIVRTKRSGHQRSGIDGQHDAIKNGKAGSSAVSLEGKASRRGLRSTEYSVAKETDAAANVEHHSGGGGGDANVSGRTRKRSGRITSTAEETEKAQTHLQEAQTDGRSLRRRTRSGTSVDGVGNGPAERTKDNDPDNSQQKSCGEEVSSSHKTSPSKIAEEDANTSDGRKDIDEVTSLNEHHQKSEDLPQSTSVHKISNASKSQQTRPGETVVQAGTITIASIGSQGCSEQPREVRNKMPKLNLPSASSEEPLSRTSPRRARQSHSQSNESKNSLMNDKQEVSEPDPATEGQCLASNGIRGGKTTPRKRTRSSSTSISPRKPPESQDVGPPEPGSPKRRRTGTVCRDLSQDFDTATLASTDITPSSYSQSECNNEIMADPQDASASIDRTLEATLNDGDGKETSKSITLTPDSFDTRTTANTVGTEVSLPQRSRHRSGTSPRGSPLKQAQLDLTKSPTRRGLRSGGAIPETPPEEIQGSGVTDNNTDNNRVETTPSVSPTISPRKSSGKKKGSGKKDGVLPKEEGRELVGESREQTQEAGLSREDVDCQAEEWYEDVDETEPFYFESDHMAIKGNKDYRMLLRTLTTLEAQRKQAIQDLDRLLECRDKALKNPIKFVHKLQHKEMLSLPHSQRVVTCPDIDWGRYIGPPETNELLGLVSQPRSMRPSKSASNLAHSQVGCGSCGLSQIKPVPTTSTASQALPSGAGVPASLEPNKPSTSSISDEAQSTDVSEMKPEQKVEIVRGRVAEGNKPPTFNQLWTRDEQRRLEEFLVKYPTEDVEARRWEKIAKALGNRTAQQVASRVQKYFIKLMKAGMPVPGRLPSVSTYQNCRKGKKIHPFTKPLFQPSTFLQSIQPPVYMSEDDPYSYTLDDDDDELVSDDESIPVDVRDTSEYQELIQLKLMKRKKVRQQGHAGYRCDGCDMEPILGVRWHCIECPEPISTDLCQNCVNCNFSSKHHSSSHRMEPVHTGYSQSYVDGDYTSFEPSSGDYNYLDPNYNPMQATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YND0</accession>
    <name>A0A8B7YND0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110981480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094774.1">
        <property type="nucleotide sequence ID" value="XM_022239082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YND0"/>
    <dbReference type="GeneID" id="110981480"/>
    <dbReference type="KEGG" id="aplc:110981480"/>
    <dbReference type="OMA" id="IPCQPKN"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="34"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022094774.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="49953" checksum="880CA0DB179F7A93" modified="2022-01-19" version="1">MTRRRWSYRRPQRASDAVHPPEAGAADGGWAWMVCLGASLGHMLNPGYLSSQGVLYIEWKEHFDTSATTSSWILTLPWLASSPFCLIMGILAPRLGIRRLTMIGGTLAGLSTILGSFATEMWQLYLCGISSGIAMSMILPSGNIMITKYFKKRYALANGLNLLGVNVGQMVFPPLIRLLIANYGWKGAMFILGAIQMNLVVASALFRPLKAKHTSDLRRQTSLEMEDIRSGGGTRSEGQNFLFLKVLTRVPFTLSLALLFLYSMAWTIYLSHLPSRAKEAGWSEDQGAMLLTIFAIIAILTRTTHGWFVDRGYIGSFQLEFGALSGAALASFLNPVSDSYGYLVGCSVLLGASLGVASPLMIVIIKRLVSDADIPASMSWFVAVFSFAQGTGSVVAGNIYDLTGSYVATYLTGGGFFAASLSLLVLVFILKRRQTGVPIGRKDPAPPGDPEVQGQITQSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQR9</accession>
    <name>A0A8B7YQR9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polycomb protein EED-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110981501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat ESC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094805.1">
        <property type="nucleotide sequence ID" value="XM_022239113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQR9"/>
    <dbReference type="GeneID" id="110981501"/>
    <dbReference type="KEGG" id="aplc:110981501"/>
    <dbReference type="CTD" id="8726"/>
    <dbReference type="OMA" id="RDVHRNY"/>
    <dbReference type="OrthoDB" id="7318948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000056">
        <property type="entry name" value="Polycomb protein eed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051243">
        <property type="entry name" value="PcG_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10253">
        <property type="entry name" value="POLYCOMB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022094805.1"/>
        </source>
    </evidence>
    <sequence length="443" mass="49732" checksum="975CDF35DA25BACC" modified="2022-01-19" version="1">MSDKEEIESGSVLKRPKSLPQNGNQNTASGDENSLELDDGQSEASTPTAESNSRSDTPTGSTTGSFNRKSNRGRWRSTKNKLQYKCNGSLKEDHGLPIFGVTFNPFYKEGDALVFATVGSNRVSVYELVEGGGMKLLQSYIDADSDESFYTCAWSYEEKTGLPLLAVAGSRGTIRLISPITMQCVKHYIAHGNAVNELKFHPKDCNLLLSVSKDHSVRLWNIQTDSLVIVFGGVEGHRDEVLSADFDIDGTKMVSCGMDHSLKMWHLMTSMVQEAISSSYEYSASKTDRPFKTLFVNTPDFSTRDIHRNYVDCVRWLGEFVLSKSCENCIVCWKPGSLSDTLEDLKPSDSRVTVLHKFEYAQCDIWFMRFSMDYSQKILALGNQVGKLYVWDLDVEDPSKTRCTKLTHPKCLSAIRQTTLSRDGTVIISVCDNSTVWRWDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YR74</accession>
    <name>A0A8B7YR74_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rho GTPase-activating protein 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110981596</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094955.1">
        <property type="nucleotide sequence ID" value="XM_022239263.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981596"/>
    <dbReference type="KEGG" id="aplc:110981596"/>
    <dbReference type="CTD" id="80728"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.530:FF:000020">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000022">
        <property type="entry name" value="Rho GTPase activating protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000011">
        <property type="entry name" value="Rho GTPase-activating protein 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="11">
        <location>
            <begin position="927"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="10">
        <location>
            <begin position="1096"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="711"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="750"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="862"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="604"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022094955.1"/>
        </source>
    </evidence>
    <sequence length="1288" mass="146835" checksum="BFD39D81BFCB336A" modified="2022-01-19" version="1">MTERVEWVEIIEPKTQRPMYGNLRTGELAWEPPSNAKVKKRDNNQWWELFDPKTKRFYYYNEMLEKTVWHRPLNCDIIPLAKLQTLKLNTEVRPDDGDWAKQRQQSSQRHRHRRSREHHNRDRRTGSERDNATNTASEGLLEDHTRAESANGTGPRFHKRMDSLDERHIHGSPVENRRKPTQAATVPPPGVSHGSPQSRRAYRYPLDQQQQALSYQQQQQQQHQHQQQQASFDQLRRLRSDSEPVEPSPHALVGVEKRRRSSTDNSRMHHHPGFERQNSGRGDALRGVDLLRSSGRSFERDGSPPMGYQQRGSPRYQDGVGVNSSSQGDMYRDGFGGGSPQFGMPYGQGYPPHPQNRHYQHERSDSQLSISSQHSVGGGVSGGGSADHQHHHHQEEGSPVRTVQDDIRKPVPSPRLKKKSKMPRMGLGAVQHHAQPPPHPSPTSAHGHAPHHPQQQHSIPGIPHSQSGERFQQFQQSPPLQHGQFQPQLPPPPPVSDYRSGTPTSATTAFTFPQHLGHYPYDRQDSFEGSPTTVPVTYHYNVQTPDSSASQDSFTPLESSDLPHHYPTKAEFRSNLHKHSESQLSQTSQHSLSSQHSDSSLRQITSDSQSSDDVLRSSTPPQQPKPDNHLVHSVQQQQQQQAPPQSEDSTSQHVFPKASQVQKFKPKQKPRRIIEDGPNPIYENLDFIHQKQREDHQRVRLRELDQIHYATLEPPQVPPRQRRPLSGMPPAMSIIPNGDSEVIEEGQLDLRDDGSQENLNKSFDSDENDDEVKVSQEALVSEDLGSVAEDGTLNDGTVPNEDQEDDEDEQGETVHESLRRTRKQQQQDNGSMAPCLLPTLERSISVQDQRPSSLVIGMVKPPSDEWKQKHGTVPGAIKPSPSLITMGRSKKPSSSESDLENYAAENVNRHKKGILRRKIPLAQMLSFTKDPIRKPMLLTRDKVVKKEAVDVFKLIQCYMGDRALKNLTHESVSLDLVRRGWTVEGLRDEMYIQVCRQTTANYVDDSLRRGWELMAIFLNFFPPSIRFFSYLEGYIYKHLTGDFDTRQVPVRQYADHCYKKLERIAQTGARKGVKKITLEEINLAKDSVFHPSLFGNTLDEVMELQKERFPDRKLPWIAVVLAEEVLRLEGEKVEGIFRVPGDIDEVNALKVKCDQWIMPQCDDANIPASLLKLWYRDLYDPLIPMEFYERCVSCGENAEAALAIVQELPDLNRLVLCHFIKFLQIFSQEENVSRTKMDINNLAMVMAPNCLRCASDNPQIIFENTRKEMSFIRLLITNLDTIFMAGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSN2</accession>
    <name>A0A8B7YSN2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110981955 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110981955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095707.1">
        <property type="nucleotide sequence ID" value="XM_022240015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSN2"/>
    <dbReference type="GeneID" id="110981955"/>
    <dbReference type="KEGG" id="aplc:110981955"/>
    <dbReference type="OrthoDB" id="412240at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07207">
        <property type="entry name" value="Pat_ExoU_VipD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052580">
        <property type="entry name" value="Lipid_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46394">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46394:SF1">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="42"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="377"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="3">
        <location>
            <begin position="46"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="3">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="3">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022095707.1"/>
        </source>
    </evidence>
    <sequence length="681" mass="78254" checksum="DC30C490FA018B18" modified="2022-01-19" version="1">MSSKLKKTFRLKTVKLPTVHEPILTEDECDELSRYQYPWHNIVFEGGGMKGFAYGGAVRVLEETGIWSQVKRLAGSSAGAVTAGLLAVGYNSHDLEALFNHPDLERIFLDARFGLFSLFPNMRKRFGWHPGNKLYSWFGKMLYKKTGNADITFEQVYTMYGKELCICVTNINFLDCFYCHVKTTPDMPIRMAMRMSGSIPGVFCTVKNSLSSFPDHYVDGGLLVNYPIHAFDGWYLSMRPEDTFLKRVQPLRDIRKLWDRKERFRHKNERTLGLLLYSDFEPEVMKDALNKRHSYYQDYVQATPNTKLAKKRMKKAKSNYIETQHNILMEAMDKLLAELNKQDVNMDGNIQLDEWMKAFNSKDSEFTDEYKKILFDEDGSDPEKIFNKLDFDQNGEISYRELLYWAEKRGLKLLSAFRGYERREIKSMTEFFSTLMECLLLNMKRVFIQICAVFLTTSLLREIQRQCHRGMFVTVPVRQERVHCIVVWESVKFSSTKGASVAKNITLSLDSAPGSWSTADNDLFRTVGIDCRYLDAMDFNMDTDDKRFLIEQGKLGCMAYLREFVDKFKPPPRRKKLMSQDSKKLDPVTLKVTRLLNSESDAEGLASPMPPTTAVPEDAPDDIFGREMQEVSMKVDKPSSPACNKHVKITLPDMPEDDHDSSRSVASCEDTQLVIGANAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVG7</accession>
    <name>A0A8B7YVG7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Opioid growth factor receptor-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110982410</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096474.1">
        <property type="nucleotide sequence ID" value="XM_022240782.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096475.1">
        <property type="nucleotide sequence ID" value="XM_022240783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVG7"/>
    <dbReference type="GeneID" id="110982410"/>
    <dbReference type="KEGG" id="aplc:110982410"/>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="3">
        <location>
            <begin position="231"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022096474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022096475.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48313" checksum="D4FCBDB3C5DCFFA8" modified="2022-01-19" version="1">MRRAKRKRAVGQSMPGDNKANKKVKDRLSFVASGDEKQTSLHKFFSSAEDVHVQATADRGGIRGTISTGSASSSLPSSPRRGKSRQSHSTNFSEIDSAENGQKSGASRGEAKGTWFDEKATKTKSQQGAAKSQTNDRDQAALSSDSGKPGGSKVKSEDLKNVHSISDSESDTSSADTQPQTPRKSRTSWLGGIRSSPKRQPARASSPSAWSARDTEAYRNRYPNKKDDKNLKDNWEFYSNKIPSKPRGTYIDVMHEHWFGDYSLLEEHHGYIQWLFPIREKGMNWQSQELQLHEAERICKDKKCCERVIKSYELMLDFWGMRLKDRRSGEIGRADNWKERFQNLNRSSHNYLRITRMLKSLGELGHEHLKFPFLKFVLGEAVVEKTLANAQRSCLHYWVHTLRINAERSAMQDFADTLLTKKSGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW05</accession>
    <name>A0A8B7YW05_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monocarboxylate transporter 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097494.1">
        <property type="nucleotide sequence ID" value="XM_022241802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW05"/>
    <dbReference type="GeneID" id="110982971"/>
    <dbReference type="KEGG" id="aplc:110982971"/>
    <dbReference type="OMA" id="WIAVFTR"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022097494.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="36712" checksum="6315D1DE56F4017E" modified="2022-01-19" version="1">MVCGAMIGVAYIGGSFANTDVQLAWLFVLFAGVGLGVSNVLAKEAVGRRFTKNYATASGIARTGYAVGLLVFAPLIQLFLNTYGWRGTMMLMGGVSLHLVVCGAVLTTSGKVTPQQTMYHQVSDQENSTSTVSQNTLAHRCSGVRENLCKNLDMRLLGIGHFWAPAVMMCCTIFADDMWIIYFVSQAQSNGFTAEQAGSFVSMASVGGVIGKVVQGLLTDCGVISSWSLTAMSIILSSAGYCSTPLLTSYWASAATAFLILCSSGVLACQVDVFIKQVMGVELLAGAFAWVGLLTAGMSFFAGFLPGLLYDLAGSYTAAFLIVGAVQGIPLIPLAILRYSYGRVESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YX53</accession>
    <name>A0A8B7YX53_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982736</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022097065.1">
        <property type="nucleotide sequence ID" value="XM_022241373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YX53"/>
    <dbReference type="GeneID" id="110982736"/>
    <dbReference type="KEGG" id="aplc:110982736"/>
    <dbReference type="OMA" id="HKQKKDT"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17958">
        <property type="entry name" value="DEADc_DDX43_DDX53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="237"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="424"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="589"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="647"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022097065.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="75541" checksum="992EACC589B7DA57" modified="2022-01-19" version="1">MPSRGRGEFGSHIQSQEFSGRGTRQWNSPGETVSVEPTDVGRLIGRQGSKIRELQDESGARIKVPRDQENDDGTIPVELRGTEEAIEKARQMIEELLRPPLYRAKPSLPSTYNSSSLSSAAGTTTVTDGEVKRPTINWKKALADAASSELEKWKDYPAVIKDFYIISPSIQNMTEFEAEEIRESLGVTVQDDCKDSPRPILNPVRTFEEAFQHYPEILREIRKQKFEKPSTIQSQGWPIALKGHDLIGIAQTGSGKTLAFLLPALIHTDLQPTPREQRSGPNVLVLSPTRELALQIHEEVSKYSYKGIKSVCVYGGGNRRQQINVVQKGVEIIIATPGRLNDLIMNGIVDVKSVTFLVLDEADRMLDMGFEPQIMKILLDVRPDRQTIMTSATWPEGVKRLARKYMKNPFHVNVGSLDLSACHSVTQLVEVIDEEYKRERLIEFIESLQEDEKLLVFVGRKSMADELSSEMSLLNISVQCIHGDREQYDREQALSDFKDGSVRILIATDVASRGLDIKDITHVLNYDCPSHIEEYVHRVGRTGRAGRTGTSLTLMTRRDWRWAGDIMRIMAEANQEIPDDLMEMAERYERHKEKKEQERSLERENGGGGGYRRDGNQGGGRGYRGGSREEGYWGGFSSGGLGGGFGFGGGRGRGRGGRGGRRGGGKYDAFDGFFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY51</accession>
    <name>A0A8B7YY51_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Toll-like receptor Tollo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Toll-like receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098268.1">
        <property type="nucleotide sequence ID" value="XM_022242576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY51"/>
    <dbReference type="GeneID" id="110983365"/>
    <dbReference type="KEGG" id="aplc:110983365"/>
    <dbReference type="OMA" id="ECISTNI"/>
    <dbReference type="OrthoDB" id="2015831at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001164">
        <property type="entry name" value="GH01279p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000026">
        <property type="entry name" value="Toll-like receptor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365:SF541">
        <property type="entry name" value="PROTEIN TOLL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24365">
        <property type="entry name" value="TOLL-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01537">
        <property type="entry name" value="INTRLKN1R1F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TIR" evidence="11">
        <location>
            <begin position="846"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098268.1"/>
        </source>
    </evidence>
    <sequence length="1017" mass="116296" checksum="ACA80C9CFE03E946" modified="2022-01-19" version="1">MDVTCKMHHWEKFYVYWCRLLLLGISVLAVKVRTSCSANYSGCINMTNERTGTLEGLDCNCNSQMLLLSDQLPQISSLILDGGDCPASWDAVRWLTTQLQSPELLEFLSVSNSRMDIREHDMNLLQNLKEFSVSRGSARFLHPRSFSQLRHLESLTLKGLRLEHFPDAVTGNFQTSINQTDITDMPLPSLQHLDLSGNAISDIPDRAFLHLFNLTYLDLAKNRLQRLDAEPLRYLRKLRTLNVSLNRIFALPHQGFSGILPHLQTLVMKNAGIFTLSMGTFEGLAHLQSLDLSFGVMATVHPLSLQGLDSLEEINMFFNPMLQSLPEQLLRPVNKTLRKINLSECKLSSIPKQFLEELPWLEEVNLSTNKISSMVNISFKGSTRLKRLNIACNSVTDIPLNFFEQTPSLEAVHLEGNSIASVRGFTFWNLDNLQSIDLSQNNLTFVEKQAFYNLQSLETLNLNNNFLARVPNNALYNIPALQELNLADNHLTNFPELPFVNRDALNARMYPKKAVIVDMRRNWLTCDCHTYRLIGDHEYIDMFWPGGNLLANLRFKKYEELLCVWPPRLRGQALYAPQQEDKLNPHFANLKSHCTDQCECYTRCSDSLNITLCYGNLKSVPQNLSKDTNVLDLSGNHLVKIGGTFQGLASLTALYLEYNQIRAVTQEDFQSLPNLTLLNLQHNAISTIEPESFANLQKLQFLYLDHNLLTGMQKEVLNSIPPLKEITLNSNPLICDCDLMWLKDWLQVQAISMDDVDSINCTTQSNETGAVVYFDDHKFMCNSTDVDVIIHDQNAETVTVCFGVLVFLMSISAIAYRFRRVIQVIVYNRTGWRFSNKLDKDMTRAYLYDAFISFSTDDLDFVTQELVPKLEGHRPPFRLCIHQRDFVVGECISTNIINAVETSRRTLIVLSNNFLASEWCSFEFKAAQQQLLKDHHKRLMVILLEKVDKNLLDKDLKLYLSTNTYLERSDTLFWEKLYFAMPDKKTVGQMHSTNNEDAVTMARDEVELQGELQELIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3K3</accession>
    <name>A0A8B7Z3K3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iodotyrosine deiodinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110984378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100214.1">
        <property type="nucleotide sequence ID" value="XM_022244522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3K3"/>
    <dbReference type="GeneID" id="110984378"/>
    <dbReference type="KEGG" id="aplc:110984378"/>
    <dbReference type="OMA" id="DIMMHIA"/>
    <dbReference type="OrthoDB" id="41362at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050627">
        <property type="entry name" value="Nitroreductase/BluB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026:SF90">
        <property type="entry name" value="IODOTYROSINE DEIODINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23026">
        <property type="entry name" value="NADPH NITROREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022100214.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="12976" checksum="E7D75A0349F0187D" modified="2022-01-19" version="1">MENSTLSWYATRPKGCIAPYIIFKQQFGVNVKGEKQTNYYREISASIATGILLAALHNAGLVTVTTTPMMNAGPRLRTLLERPISEKVLVLLPVGHPEDGAMVPDLQPKALQEIMVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3Q7</accession>
    <name>A0A8B7Z3Q7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tyrosine-protein kinase receptor Tie-1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110984397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100269.1">
        <property type="nucleotide sequence ID" value="XM_022244577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3Q7"/>
    <dbReference type="GeneID" id="110984397"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052108">
        <property type="entry name" value="MEGF/SIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24035:SF109">
        <property type="entry name" value="PROTEIN DRAPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034606427" evidence="4">
        <location>
            <begin position="18"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022100269.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="54529" checksum="2EEA4DD2E5BADEC4" modified="2022-01-19" version="1">MAVLTLMVLVLFQKTAGDTVHQTMVTTAPYGAGLDGVSVKCIRSSPDEHLPFSYSRPFKLDIPGVRNQTTTFPEGTTLLVADNTLEWVLPSITEAAGMYFCQGWNTYTKLTSTVYSIIHSNQRKFEPADGQVTKTVNKGENVTLAVIPANNGSLPLWHRFTYVGSRSNLASMQYVIQLSSGMVADGDFFVVTERDAALDDNHFGMIRLIIRGCVAGKWGPPDCAKVCEMCYNGGVCDDETGDCICPPGFNGPNCLTACGKHKFGWHCEYECGAENIIQSCTGSQFGLPDPYGNSCISGYYGKDCDTECSNGTFGAGCTQTCHCKSGTCDGFTGECTGSPECATGWSGSNCQIPDKCPVGYYGSECIRKCLCFNRTVPEGECDRVTGECSTPTEPLNVVLLAAIGGGILVVLIGVSLSVTFACLGRNRRQRHRTKQRDRRSNDDSAEYENNDAQDLRAEGSRPMTQEELPAQFYENDFRNLPKADVGHDEARCPYVEVVATPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4U8</accession>
    <name>A0A8B7Z4U8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Carnitine O-palmitoyltransferase 1, liver isoform-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110984195</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099815.1">
        <property type="nucleotide sequence ID" value="XM_022244123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4U8"/>
    <dbReference type="GeneID" id="110984195"/>
    <dbReference type="KEGG" id="aplc:110984195"/>
    <dbReference type="OMA" id="FVSDWWE"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000002">
        <property type="entry name" value="carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF112">
        <property type="entry name" value="CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="12">
        <location>
            <begin position="185"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022099815.1"/>
        </source>
    </evidence>
    <sequence length="795" mass="90999" checksum="7FDDF4553C7F53B3" modified="2022-01-19" version="1">MAEARSAVKEPRVDVLYFEEGQEDEWKVALKALRRSCVRRFYRTRNLIWNGLWPTSSWNLLTSVAVVSLLMITEFEFCEPLNDKFWTLGEYVYISRGPPYFYLKVLIVSLLVGVCFFIALLHVRRYLLRILLAYKGWLHETPRNQSWSTLAWGACVRIICGQTLSALVPALSPGTYSFQLSLPRMPVPSLDDTIRQFLESMRPLLDKEEFETLQKQAKHFKKTVGPKLQRLLYLKSWWASNYITDWWEKYIYLMNRSPIAINSSYYCLGNSFWKPTHVQSARAAAKSYAIMSFKRKIEREQVPPLVIRNTIPICMQQYERLFATVRIPGEDFDELVHYDSSVSKHIVVLRRGFFYKLDMFDSIGQPLSPLTLEQQFIWIMEDADKKGAEGKGSAAGSLGAFTALERSDWFRKRSKYLSSGVNRESLEVIDKAAFLVMLETCEFDNLSDRGKFLLHGSGSSHWFDKSLSMFIFTDGKFGYNVEHSWGDAPVVAHLQEYACTDEVAEGRYGPDGHCVPMEGFVQAAIKAPVPLEWDISEEMSRDIRDALSFAIKNNDDLDLCVLNHDAYGKGFVKKCKLSPDAYVQLALQLAYYMDEGKFALTYEASMTRLYLAGRTETVRPLTQDSCNFVRAMMEDNRSAEEKIRLLRKASDMHTKLYKGCMSGKGWDRHLFALYVACKGLKYDSEFLHHALTHPWTLSTSQTPQQQIAGNQSINTVEHRDKASPGGGFGPVSDEGYGVCYMLPEDSRFFFHVSSKHSCPLTNSKRFMSNIFKALADMKKIFDDADEAAEAAKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z535</accession>
    <name>A0A8B7Z535_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110983474</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098451.1">
        <property type="nucleotide sequence ID" value="XM_022242759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z535"/>
    <dbReference type="GeneID" id="110983474"/>
    <dbReference type="KEGG" id="aplc:110983474"/>
    <dbReference type="OMA" id="SEECICC"/>
    <dbReference type="OrthoDB" id="5955457at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046815">
        <property type="entry name" value="P2RX7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20478">
        <property type="entry name" value="P2RX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="P2X purinoreceptor 7 intracellular" evidence="2">
        <location>
            <begin position="99"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022098451.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="27479" checksum="3663CA0915E3B6F9" modified="2022-01-19" version="1">MTSSAEHSMQSTEAHMELCTRSYTYTYTRSFVYSAFNENMAERSSSSESSSDSEVDRDFSYESYSDDNRDEAGQIMPYMYEPEVESDDDDGEHEIAGVDYDNEGRLNNINWCSCGECQIMPAVRESVCCKEINQVVQKMDNIEVDLNCITEHPGFYSVCLDQWVLETAYFQYRQQYGQGRHNATENQKNRHTAYRQMARWCWGFLGQNVRVPLPSCAVHKIREKYPSNEYRGFQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z790</accession>
    <name>A0A8B7Z790_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">tRNA (guanine(10)-N(2))-methyltransferase TRMT11</fullName>
            <ecNumber evidence="12">2.1.1.214</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA methyltransferase 11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">LOC110985079</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(10) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43128"/>
            <dbReference type="Rhea" id="RHEA-COMP:10355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.214"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:43129"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the heterodimeric TRMT11-TRM112 methyltransferase complex; this complex forms an active tRNA methyltransferase, where TRMT112 acts as an activator of the catalytic subunit TRMT11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022101513.1">
        <property type="nucleotide sequence ID" value="XM_022245821.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101514.1">
        <property type="nucleotide sequence ID" value="XM_022245822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z790"/>
    <dbReference type="GeneID" id="110985079"/>
    <dbReference type="KEGG" id="aplc:110985079"/>
    <dbReference type="CTD" id="60487"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="17">
        <location>
            <begin position="16"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="16">
        <location>
            <begin position="200"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00075308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022101513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022101514.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="53963" checksum="F44C6F3B3D02016E" modified="2022-01-19" version="1">MSQHAIGFKMAATMRQYLLCFAQEHVEFRLAELRAITSLLGIKVDLNDPEYDQMNPFLLLRLPSNSCAHKIMGRTMLGRFMIELWGHGNSWSELHQSLQLYPDERKAPFSQNADTSFCFRMRTVGKKLGMEEKLAIIEDLVDFLDFKGKVDLKNPQQVFHIYADYGQTPNKIPDQPYKIYFGRLISEGQRQLEQLYSVKKRHFIGNTSMDATLSLLMANQAQVRPGMVTFDPFVGTGSLLVAAAHFGSYVLGGDININIIHGRGKTSRKGVGQYRGKDENIRANLRQYGLEHLYLDVLVSDFSCQVWRVQPLFDAIITDPPYGIRESTRKIGGSKELTVNEEQEAQHIPPTTAYHLSDIFTDLLNFSARFLRLHGRLVYWLPVCRAEYTEDQIPHHPCLSLVANSEQPLSTTIGRRLVTMEKTRHMEGLEGDSPRAEIRDDCYRDHNAIREKVFGQNAKDLKMKVMSKTESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z947</accession>
    <name>A0A8B7Z947_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription termination factor 4, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110984969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101330.1">
        <property type="nucleotide sequence ID" value="XM_022245638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z947"/>
    <dbReference type="GeneID" id="110984969"/>
    <dbReference type="KEGG" id="aplc:110984969"/>
    <dbReference type="OrthoDB" id="9991972at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061668">
        <property type="term" value="P:mitochondrial ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF203">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022101330.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="48737" checksum="9EBF0D85F68A8644" modified="2022-01-19" version="1">MLSLQRLRSSMTWQLTKMQLELGWCRDVLGRISSALHAHKYCHQLSLPGQNVRPYMYMCAYACARTVGGKFQLVPHSKRHAALASFVDSHWGWKQSGAFLHSGELNVLTRTAQEDTPKGKDMVTFIRDDNDLERFLGHITDLLSTPDFSKVRIPVEEAKTRAEELVHRLLEMKADPRNIYAFLCSKPRVLSAQQDALMQNLQFLEELRVVGNQALLVLDRNPKVWGADEAVLRDRVRRLRKLGLVEGSLQKVITNWPAILTLRKSRLNGSIDMLRKCQFSGRQITAIVISSPQVLDSQPADIELRFQYVYFTMGLQKQADMVQANLFKYSLEHIRCRHLVLERLGVYQLPSKPGGTRADNPKLCRIVDCTDARFAQKCAGISPEEYETFQRNLEDEAKRDDEGDTEEETDEGFVDYDHDDGTRHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9A2</accession>
    <name>A0A8B7Z9A2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110985014</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110985014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101390.1">
        <property type="nucleotide sequence ID" value="XM_022245698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9A2"/>
    <dbReference type="GeneID" id="110985014"/>
    <dbReference type="KEGG" id="aplc:110985014"/>
    <dbReference type="OMA" id="DPGEKHL"/>
    <dbReference type="OrthoDB" id="426657at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="430"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="517"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="606"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="542"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022101390.1"/>
        </source>
    </evidence>
    <sequence length="987" mass="108182" checksum="311A75845B015419" modified="2022-01-19" version="1">MATQASLFEITGEIIEILTCPICCERYDDADRAAKFLPCLHGFCLVCLDNLTRRNPGEVDFQCPLCRRDTAIPRGGVREFPDNFIAKKLKPLERILNVDVTRPEGLRCGSCIVDGDPAVSFCSDAGCVCFLCESCDRAHRTMHMFEGHIVSSLEQLQQRSHIPLPRQTLKCEQHRQDLSMFCDEESCQRAMCLVCFATAHNGHSVLDLERKSTAVKEELKNLAGAVADKKVKCEGISRYIDTEIKQTADLLVEMSSTVSSLFDSLKSKLETRKENVLADLTEVCFKRTNQLKHQNSQTKLIAAQMDSASQFADKACETGSPVDLLMARGQIISRLHELIAVDVERPVLFSPTGESFIILTERHGRVLSKIEELIPSLGHFGASNVFPEQIQTLKLDFPIKCGTPWVVGEINKVRIRADGPSSTSLDRLLGMIHAYLESPDGSRIECKCVEICGDCFELALKPLVAGLHQLNISLSRVPIEESPFLVDVVQVSENQDPGVEIILSDAFAGAEHVVFFKLRGPSSRRTRLSSLSARYFMPGRDQVQAGESSTEANSDRSRSESEAWVEETDEQGTYRLVYTPPAAGKVYLTIFVDSKPTTETPFVINVNPLNPNSTQVVGNIMGKCPPLTAVVNMPYTVTLTTRDWEGKRLTTGGYNVTAMINTPRHPDRWQQAEVVDNQDGSYKVIFTPRSKDRHIVDLKICGYKLEPGMPLIIAVEESLPFKDPPDGYAAPSGMAVDIDKGIVYVEDAKQGCIHRLATDGGFMPGGAISISVRKKLQIAVNSEGKLVLLVPNLRCVITCTAQGEEEHRWVCAGDNAKPVNVIVSSSGNVVIGDSKSQTLFIYRATGGDPLCRIPLPPKSLTAGVSNVCVEPHTDNIIVATHSEPYKLLEFAADGGRTVWNSPAQSNQLALASMPSGATIVAVLGSVLVLGPGGPVVVRKFPTEYIYTGLALAEEGFFLAFDPGEKHLVKYSYTSNQSDNEGEIPDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAA9</accession>
    <name>A0A8B7ZAA9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110984361</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100186.1">
        <property type="nucleotide sequence ID" value="XM_022244494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAA9"/>
    <dbReference type="GeneID" id="110984361"/>
    <dbReference type="KEGG" id="aplc:110984361"/>
    <dbReference type="OMA" id="FSACHED"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022100186.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26052" checksum="1B6A8E77D9BA4403" modified="2022-01-19" version="1">MADGTVSCEEFGRNVSEFLQVSSLLKDGWELRDAEALALRGCPYLVKRNVLRAPHIADAGSTKGLRESAQPEETGTDAAPRNREEEEDCPEDGDEDVDSRTPDGQAAVGVCRFDYHIVYNHSFSVPTLYFSACHEDGKILSLDEVWRSVPSHYQKRLQSERWTFITQQEHPILGRPFYSLHPCHTADLMKAVLNAASQTATSHRNYLVTWLSSVGPVVGLSLPLRYAKLCEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAT4</accession>
    <name>A0A8B7ZAT4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeodomain transcription factor 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110985784</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102789.1">
        <property type="nucleotide sequence ID" value="XM_022247097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAT4"/>
    <dbReference type="GeneID" id="110985784"/>
    <dbReference type="KEGG" id="aplc:110985784"/>
    <dbReference type="OrthoDB" id="10066656at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039775">
        <property type="entry name" value="PHTF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021980">
        <property type="entry name" value="PHTF1/2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680:SF6">
        <property type="entry name" value="PROTEIN PHTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12680">
        <property type="entry name" value="PUTATIVE HOMEODOMAIN TRANSCRIPTION FACTOR PHTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12129">
        <property type="entry name" value="PHTF1-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="623"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="708"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="829"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="PHTF1/2 N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="387"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022102789.1"/>
        </source>
    </evidence>
    <sequence length="862" mass="96796" checksum="60483BE9CE1AE691" modified="2022-01-19" version="1">MLGFSGINEAISGFQQQIGAYDKELWEEHVEIKELNIQGLPANNIPLRTGRLKTELIDIDLVRGSTFTKAKPEHSLGASARKGLIRVLFFPFYFQWWKQQLSKWMLVCLLVLYFLQALSITVYFLYSPSEAQQPIFFTEVFTPVVLALVLGTVYSLVVCTTVKKSRALRRRMTRRSREVKTKQRKPTSEDSNGSYSKKRGMRRSQSLPCTADTYYQVRQARRNLARRFSRPGIVVEDSTTGRRESLVEGTDEASAEDGLGNDGRQPPEYIRGLQGDETTGYTEEDFTLLGKPIEETDIAGEILLPDLDPKTLGETDTAVACVVPKTAPSAAAEDATGDLATVKGQGLLNTSKPAEESKSYVTQNPGAEVGTVEVSSVSLLERAKKSSITRFSDDVSDNPQHASDSEGPAEDREERGRERGLRSRAGVRKGRRKRQEYGSSNESDLDTRPVRQVRSLEQDSHLRGPSRFGDSDMDDPSWGETAEEVSSSGTSSESSESDSSDSENDKNEEIPQFEDPFKLLPATVTSTPSACTNTEKIRVRIFEGDECKKADLSVLEISCYINTKVRNTRSSCDYILLGALCAVTLASIPISFRLRGVSFLDLDLSWLTSACLQRAAHTFRVDAVAYVIVGLCSMERLALSLMFFFLLSVAEKTYKQRCLFAKYFSHLTSTRRARKSGLPHFRLDKVSNIKAWLSLRSFLKKRGPQRSIDIIVSSAFMLTLCMMSVLCVEMLQKEFKFLTHLFNWELIAWTFCMCPFLLRFMTLGSTINQKFRNTSVLLTEQINLYLHMEKKPHKKDDLMLANNVLKLASKLLKEIETPFKIAGMSMNPVLYNITRVVVLSAFSGVLTELLGFKLKLWKIKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAY2</accession>
    <name>A0A8B7ZAY2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbohydrate sulfotransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100406.1">
        <property type="nucleotide sequence ID" value="XM_022244714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAY2"/>
    <dbReference type="GeneID" id="110984485"/>
    <dbReference type="KEGG" id="aplc:110984485"/>
    <dbReference type="OMA" id="DRWHLRN"/>
    <dbReference type="OrthoDB" id="6156372at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF71">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="211"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100406.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="61634" checksum="40721F9DC15C0E42" modified="2022-01-19" version="1">MQVGLYRVKCPLTRYLCTCSTCTTDGVSRYGELSSLTIHRMRLPRPKTTASNRRILLFGMISASAVWISLIYVGTRVEMLPKITGLWRNGRSSAGTRAGEELQKYEDTNARGNSAGEVVHKQGQPSWGRPNITGDRASQPLGIHVLELQAGQDRSESLQDLYPSIDALLRDMGVMNVSETSAEHDSGSSPDGKAHARGSAVLSTPDSKVRVIILASMRTGSSFVGEFLGNNQDAFYLFEPGLSVTETFERYKLGPGVQENVHLKMLQKLFRCDFQGLGFYIKWLSRHSLQSLHKIAPRFYSSCTRTLSGRRTEARWAQCSITQGMATSICKKSDFIVVKSIRVPDINLLLPMLEDKTETNLKVIHLVRDPRAMMKSRVGAMRDTNLRRLSTDDKYTLSTYCKYNLANLELGTRRPSLKQRYMFLRYEDAAQDPRGAAARIYQFLGRSGQVPESVTKWIESNTVTYKPGIYSTTRNSVYAYQKWRLTLPAWTAVEIQKTGQCAGMMRRMGYHSLDDRWHLRNLSRRLVDPIPPTKDDEKYDWAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBD9</accession>
    <name>A0A8B7ZBD9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RIIa domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102989.1">
        <property type="nucleotide sequence ID" value="XM_022247297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBD9"/>
    <dbReference type="GeneID" id="110985868"/>
    <dbReference type="KEGG" id="aplc:110985868"/>
    <dbReference type="CTD" id="284485"/>
    <dbReference type="OMA" id="EGMEPYD"/>
    <dbReference type="OrthoDB" id="10249338at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22971">
        <property type="entry name" value="DD_RIIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059162">
        <property type="entry name" value="RIIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15505:SF4">
        <property type="entry name" value="RIIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIIa" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102989.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="12143" checksum="FD6992B02F43336D" modified="2022-01-19" version="1">MAVPNHNPPRGMEGYDLGALSAEQQEKLNQFKIQTRLGNEKFLRDHPEVDVLLAGFLGDVLTQRPENIRDFAADWFTKPHLKDFVQGQLKQRENALREAKFNRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC04</accession>
    <name>A0A8B7ZC04_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase NAD-binding domain-containing protein 1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102360.1">
        <property type="nucleotide sequence ID" value="XM_022246668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZC04"/>
    <dbReference type="GeneID" id="110985562"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052128">
        <property type="entry name" value="Oxidoreductase_NAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505:SF1">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00410">
        <property type="entry name" value="PHEHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase FAD/NAD(P)-binding" evidence="3">
        <location>
            <begin position="167"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102360.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33880" checksum="2580EFFCB1A93C34" modified="2022-01-19" version="1">MRMSFRTISYLIRSPAGLLCPTSSSKPISPVVKALTRRMSDHLDRTAHNFRQTGISDATIVAVKDGSSTVKLLTVQVSNPDFRFKAGQWVDFFIPGIRTVGGYSMYTPPSLLQKSLRMGLAVKYSEHAPAYWVHTQCKAGAKVGVRVGGDQIIYDPSPSDPSWDLLLIAGGIGINPMYSILQHARDLYLRSLSDPTAYRPGRVEFLYSASTSEELIFKESIQEIANDTENISCHFHVTREAVIPTSHTSDHRINGADLATSLQRLDKDRLRCFLCGPPPMIADMESLLESQGVRPDQLHTEKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEN9</accession>
    <name>A0A8B7ZEN9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransferase 1C2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104123.1">
        <property type="nucleotide sequence ID" value="XM_022248431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEN9"/>
    <dbReference type="GeneID" id="110986514"/>
    <dbReference type="KEGG" id="aplc:110986514"/>
    <dbReference type="OMA" id="CELREYE"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000433">
        <property type="entry name" value="Estrogen sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022104123.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36998" checksum="DF0C0759EDEF3B24" modified="2022-01-19" version="1">MEKYVTVEEFAEVLSRRFSPEFPCELREYEGVALAPEVDKVAEDFKTYEVREDDCWLVTYPKAGTTWVQEIVSCLMHDEYLDPAKQIHTVFRVPYLDQTIPERARRWKNMPPPHKIAEEMPSPRVLKSHFPGQLLPPQLWEKKVKIIYIIRNPKDVLVSYYYFEKMFDPQRKEQSFGELLERANSGNIMYGVWWCHYLYFWKRRHEPNILLLRYEDLKKDLRGNVERISLFLGKNLPAKKLDEITEHCKFANMKANPMANHDVLYPESTKSGRSFMRKGKVGGWKEHFTVAQNEAMDALIKEKLHGTGLTFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHI1</accession>
    <name>A0A8B7ZHI1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-like-conjugating enzyme ATG3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Autophagy-related protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110986983</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105044.1">
        <property type="nucleotide sequence ID" value="XM_022249352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHI1"/>
    <dbReference type="GeneID" id="110986983"/>
    <dbReference type="KEGG" id="aplc:110986983"/>
    <dbReference type="CTD" id="64422"/>
    <dbReference type="OMA" id="HCPTWSW"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.50:FF:000001">
        <property type="entry name" value="Autophagy-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022105044.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35055" checksum="9AE9AB716475FD06" modified="2022-01-19" version="1">MQSLVNSVKGTALNVAEFLTPVLKESKFRETGVITPEEFLCAGDHMVHHCPTWQWAAGDPSKSKPYLPKDKQYLVTKNVPCHKRCKQMEYQEENEAIIDEEDGDGGWVDTHHYADQSAAAQSDTTEVMDGKEKAQAKTADEDDDDDDDDEEAEDMEAYEESGMLEAEDSAILDTTKLQKEEGASGGESGILQTRTYDLNITYDKYYQTPRLWLYGYDENRKPLTVEQMYEDISQDHVKKTVTVESHPHLPQTMCSVHPCRHADVMKKIIHTVADGGGELGVHLYLLIFLKFVQAVIPTIEYDYTRQFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZID8</accession>
    <name>A0A8B7ZID8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Gamma-aminobutyric acid receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110986768</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104640.1">
        <property type="nucleotide sequence ID" value="XM_022248948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZID8"/>
    <dbReference type="GeneID" id="110986768"/>
    <dbReference type="KEGG" id="aplc:110986768"/>
    <dbReference type="OMA" id="GYACFNV"/>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18990">
        <property type="entry name" value="LGIC_ECD_GABAAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19049">
        <property type="entry name" value="LGIC_TM_anion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000021">
        <property type="entry name" value="Gamma-aminobutyric acid receptor isoform 3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034878129" description="Gamma-aminobutyric acid receptor subunit beta" evidence="20">
        <location>
            <begin position="24"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="31"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="240"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022104640.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="45707" checksum="229A28D13A2002E7" modified="2022-01-19" version="1">MERLLGATRICVAFFCVLQAAWCCGQGTNTTAILNSILRDYDRRLRPNDTGSPVSVKINVYIESMEGIRESTMDFAITMYFRMFWRDPRLSFEGNQTIIFKSGDMDNLWIPDVVFLYEKQAKVHTVTQINRLLRVQPDGNVASSSRVSATLSCNMMLQQFPMDRQKCTIVMSSYAYSTRDVILYVEEGSIQIEPGITIPKFSLTGSEFSNEEAIYLLGNYSTPKFHFYFMRQTESYFLTVYIPTMVLVSIAWLSFWIDAKAAPARVALGITTVLTVTTMTAGIQETLPVVTYAKAIDIWLAVCLLFVFFSLLEFGMANYLLVVQTRREKSLAGDIEQSPAKEMERNLQIETVGDGGRCCSSLWTANRLDCVARWAYPAAFLVFNAFYWIYFLAFNKANAKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZID9</accession>
    <name>A0A8B7ZID9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110985895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103031.1">
        <property type="nucleotide sequence ID" value="XM_022247339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZID9"/>
    <dbReference type="GeneID" id="110985895"/>
    <dbReference type="KEGG" id="aplc:110985895"/>
    <dbReference type="OMA" id="IVCISAW"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000008">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002229">
        <property type="entry name" value="RhesusRHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF58">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00342">
        <property type="entry name" value="RHESUSRHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="11">
        <location>
            <begin position="43"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022103031.1"/>
        </source>
    </evidence>
    <sequence length="764" mass="83976" checksum="CA079E6777608542" modified="2022-01-19" version="1">MSTVSSVASTIASTTDNSPFNTTCPVYVVHKHVMPNDWDDPIWILTSAFVIFTMQSGFGLLESGTATSKNEVNIMVKNAVDVIFGGITYWMVGYAFSFGDQEHENKNAFSGYGNFFLDVEADDTGIGQRYSHFIFQLAFATTATTIVSGAMVERTRLEAYIIFSLLNTLISSFPSHWVWAKDGFLFKMGVVDVAGGGPVHIAGGVTGLVATLMLKPRHRRYKTSDPPPMGSPTNAILGMFMLWWGWLGFNCGSTQGITKDKWALAARSAVATICSSMAGGIGGITLSYLTKRRKFDIGYLIDGVLGALVSITAMCTLCPPKFSLVIGLIGGCIACGGVELLNKLKIDDPVGVVPVHFFCGAWSLVAAGLFVKHDSIEETNNGTIQHDGLFMGGGPALLGIQLLTVVCITAWCGIIACIILKIISLTIGLRFPFHEELLGADMVEHSIGPRKYDKIKKRLTDSARYRRFEQPRRRIHSSMRQAEDFLSMRDTSVETSYDDVIRRFQDRECDDRNRSGARKLRFNPARGDAVFTISNGNSHATVIEEEHPNGDVTAPDGVDAGPTNKDENDNSVSNKKRRISTQLIRGAFRRRKKVLPKWQRKLGIENVAYIDNERAMKMKTRKARDVQFAAETSHEIGEEVAENGSVVITSRDDLRSSPCSVSVQAGPSSTRIVMVDQSTQTHPVADMCSTFVQTSAEDIFLRSIGIDADCSSIEMEVSFDMDDKIDTDATQHPRQKSFAIEESGHGMKDAFISRKANSRIEYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIQ2</accession>
    <name>A0A8B7ZIQ2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110987252</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022105518.1">
        <property type="nucleotide sequence ID" value="XM_022249826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIQ2"/>
    <dbReference type="GeneID" id="110987252"/>
    <dbReference type="KEGG" id="aplc:110987252"/>
    <dbReference type="CTD" id="2193"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000036">
        <property type="entry name" value="phenylalanine--tRNA ligase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040586">
        <property type="entry name" value="PheRS_DBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18554">
        <property type="entry name" value="PheRS_DBD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="229"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022105518.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="56341" checksum="5A2815F0ED67A71C" modified="2022-01-19" version="1">MAEILGETILQRLEKDGQISTDALAKSLQKDHQQIVGAVKSLQSLGNVIETKQQTSKYWELTLEGKAIIRSGSHEALVFQAVPQEGGIPQAELMKTVANAKIGFSKAMSAGWLEINKAAEGGPRVMRKVSSIVDKVRGQLEKVLAGEIGSLTDKEKGELKKRKLIQEVTLNTFLVMKGSEFSTSVSKPETDLTPEMLASGSWKDHKFKEYNFDALGAMPACGHLHPLLKVRAQFRQIFLEMGFTEMPTNNFIESSFWNFDALFQPQQHPARDIQDTFFIKDPQYAHEFPMDYLERVKTVHSVGGYGSQGYKTNWKIEEAKKNILRTHTTAVSTRMLYQLAQEEKFRPVKYFSIDRVFRNETLDATHLAEFHQIEGVIADYNLTLADLIGVLHAFFKKLGIEKLRFKPAYNPYTEPSMEVFSYHEGLKKWVEVGNSGVFRPEMLLPMGLPEDVVVIAWGLSLERPTMIKYGIDNIRELFGPRVNLQMVYDNPICRLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM02</accession>
    <name>A0A8B7ZM02_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melatonin receptor type 1B-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106092.1">
        <property type="nucleotide sequence ID" value="XM_022250400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM02"/>
    <dbReference type="GeneID" id="110987570"/>
    <dbReference type="KEGG" id="aplc:110987570"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022106092.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40325" checksum="FBCF3AA3D4B6D252" modified="2022-01-19" version="1">MKNVTNMTSTVNATSINPAELTFSNSERVGIGVVFLITSILAIIGNVMVIVAVIRSKSLQTTTNAFVVCLSVANLMTGLSLPWSVVGLLSLEGWPLASEVPCQLAGLVLLTSIGASLYSLAGIALNRVLIIVASPSTYQWWHMPTKIAGMISVAWLLPFLIVLVPPLCNVGKLGYDKNTHICTDVSQHPRQQDHRLAIAMVFYLVPMTTVITSYSLIFQTIRRNFRHQTEQCTATPMQPSDFDWGVGHESRKARLKQHQHSTTVNLFVNVCVFLLLNLPYGIALIIPDNKRIAVFSGMVFLMHSFVHPLLYGFKHPQFHHAFREMLHLTEDLQPSTGSGYTRNELRQNARSDKIIKGLENSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM50</accession>
    <name>A0A8B7ZM50_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110987499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105965.1">
        <property type="nucleotide sequence ID" value="XM_022250273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM50"/>
    <dbReference type="GeneID" id="110987499"/>
    <dbReference type="KEGG" id="aplc:110987499"/>
    <dbReference type="CTD" id="4736"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105965.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24337" checksum="7DB67A0F3CBE4A5D" modified="2022-01-19" version="1">MSKVTRDTLYEAVEQVLKGSQEKKRGFLETVELQINLKNYDPQKDKRFSGTVKLRTIPRPKYKVCVLGDQQHCDEAKANNIPCMDAEALKKLNKNKKLVKKLAKKYDAFLASEALIKQIPRLLGPGLNKAGKFPSLVTHSDQLVTKVEEVKATIKFQMKKVLCLAVAIGNVSMSDDDLVSNIALGINFLVSLLKKNWQNVRSLYIKSTMGKPQQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMF1</accession>
    <name>A0A8B7ZMF1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110987557</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106070.1">
        <property type="nucleotide sequence ID" value="XM_022250378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMF1"/>
    <dbReference type="GeneID" id="110987557"/>
    <dbReference type="KEGG" id="aplc:110987557"/>
    <dbReference type="OMA" id="HMLHEYI"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004245">
        <property type="entry name" value="DUF229"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974">
        <property type="entry name" value="FI08016P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10974:SF37">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02995">
        <property type="entry name" value="DUF229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106070.1"/>
        </source>
    </evidence>
    <sequence length="756" mass="86332" checksum="6D863AB8EEC529A1" modified="2022-01-19" version="1">MRRLRYLFVLLLIFISQVVVFIGLSGVNEDGGDFDRKPLGDPGNRRNSELLFGAEAVFDVGARGKKDAAPSSDEPLVGHARETPKRSQGFHTKTLEELFASSTENKNELSDDEAVKRWFGMLQNMTDTLFLDEMGPKSDSICQVPDLKAPAQMCRDEIGWECNMVPAFSSYNPSTRNITVKCPGRFRVNQVDRTESEEIVSRGSYRRKAVWKYYQGPQEIAMETEYADVVCKNKKMQDLHNYHTQFVPKPAADRQQEGRLREVKGQEPAWQPLCILTVVLDSMSRAQAHRSCGLPKTMALLKKFYRGYFSDIPPSSGHGPMSHQSFFFSRLNAISSSTLLNLTPLFSGQLYQDIDMGKVARGIYAKDIKEWIWEYAAQRGYITSYGVDNNSGLMGTRTHCKACHYRPPVLPHVEHGWQKRENEQVRPNVLSGLCDGNHMLHEYILNYTRDFLKHPYPAKWAALDLNAGHRGETESGNQVDAELAVFLEDVLKENRDLVVFILGDHGKPLHKNPSHLGSYYETLLPFLSVLMPTWLLRERPDIMANLIDNQQRYMVHADLHLSMKSLLHYPNMGEVDGAIASKAVNVFTEVIPQERSCEQANIPPWTCVCGFMQKLPESHWTPRHTTMVQKTLGYINAMHSLKWLQSSDTSALGDARTSCLDLHLRRILSVVVNENKDEDLHSARHYVYRLTFQTIEEDTVWSVVMDSDMDIKRVRQITLYQPYDVCWDRRVPLQFCVCNKASQPTPSKLYRPRSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMM2</accession>
    <name>A0A8B7ZMM2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein 63, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110986755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104611.1">
        <property type="nucleotide sequence ID" value="XM_022248919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMM2"/>
    <dbReference type="GeneID" id="110986755"/>
    <dbReference type="KEGG" id="aplc:110986755"/>
    <dbReference type="OMA" id="QEFGHAA"/>
    <dbReference type="OrthoDB" id="6019958at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016576">
        <property type="entry name" value="Ribosomal_mL63"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14520:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14520">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14978">
        <property type="entry name" value="MRP-63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022104611.1"/>
        </source>
    </evidence>
    <sequence length="107" mass="13013" checksum="499A11554F884CCC" modified="2022-01-19" version="1">MWLTQVVMAIRRSSKYTPGRLFSGKHRKHRPVTNNMVKNLMRRLEIEKENETYLCMPYLTRAEENGHAKEQNYLEYKELSDRRRSASMKPHNYIEDHLSHLKHSRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP71</accession>
    <name>A0A8B7ZP71_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ashwin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110988209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ashwin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107219.1">
        <property type="nucleotide sequence ID" value="XM_022251527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP71"/>
    <dbReference type="GeneID" id="110988209"/>
    <dbReference type="KEGG" id="aplc:110988209"/>
    <dbReference type="OMA" id="IDWLYPE"/>
    <dbReference type="OrthoDB" id="10071059at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024887">
        <property type="entry name" value="Ashwin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28359">
        <property type="entry name" value="ASHWIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28359:SF1">
        <property type="entry name" value="ASHWIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15323">
        <property type="entry name" value="Ashwin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022107219.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31564" checksum="3BD139E80408182C" modified="2022-01-19" version="1">MEQDDEPEAVVVDILHPEILSREDLADLLSQRHIKLDRPNATKEDLLEIFHRTITPLPQRAPRANRRGRTTAQVHRKLLQAKRRLQANSDQGSKVTMTVGFSKSQRNQQSPGLNSSSSSSSSPGTSRLKPPPVVTSKQRTLKLPSSKTSSWPSGSSSTTIKAAKDSTSPATNSQVDLEPKKIVTNKSTVQSKRDSRVTSPTTSAVTPDSLPQIKLKTSISPAVAPVSDKMRKMSVKPLGSDSTKIALKRPVPLDINGKTNPRSSDTTTKTSSSEDDHSPKQKIKRISWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQ90</accession>
    <name>A0A8B7ZQ90_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OCIA domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107060.1">
        <property type="nucleotide sequence ID" value="XM_022251368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQ90"/>
    <dbReference type="GeneID" id="110988116"/>
    <dbReference type="KEGG" id="aplc:110988116"/>
    <dbReference type="OMA" id="PEMTKTY"/>
    <dbReference type="OrthoDB" id="6513616at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040187">
        <property type="entry name" value="OCAD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009764">
        <property type="entry name" value="OCIA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336:SF3">
        <property type="entry name" value="OCIA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13336">
        <property type="entry name" value="OVARIAN CARCINOMA IMMUNOREACTIVE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07051">
        <property type="entry name" value="OCIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OCIA" evidence="2">
        <location>
            <begin position="35"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107060.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31192" checksum="13709602E42E2875" modified="2022-01-19" version="1">MSLTGESHPTNVPPNQNYAPHHGRGRHGGPHSQRNYEMTEEERRVFRECQTESFWYRAMPLAVGAGLLTQTLILRGMLTTSTRFGSLPKVGFACLTGYMAGKISYVNTCKQKFLKLENSPIGEMLRKGGSMPTGQGGNFGLPGFQAGSIGESDPGSPAVTRGSDSYSSFGQPDDYRANLDIDTSNVKTMDSHFDFELTNEAASELEAKRPEMTKTYEDLRRENRQKHSSQYSQVLPGHYHPRQPTPPSHDDIALKKADERPFPSVSRPRVTKNKYGDDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRW4</accession>
    <name>A0A8B7ZRW4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger-containing ubiquitin peptidase 1</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Lys-63-specific deubiquitinase ZUFSP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Zinc finger with UFM1-specific peptidase domain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110988441</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with RPA1 and RPA2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C78 family. ZUFSP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022107620.1">
        <property type="nucleotide sequence ID" value="XM_022251928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRW4"/>
    <dbReference type="GeneID" id="110988441"/>
    <dbReference type="KEGG" id="aplc:110988441"/>
    <dbReference type="CTD" id="221302"/>
    <dbReference type="OMA" id="NDHVENH"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.130:FF:000002">
        <property type="entry name" value="Zinc finger containing ubiquitin peptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF4">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MUG105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="134"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022107620.1"/>
        </source>
    </evidence>
    <sequence length="847" mass="92585" checksum="74432517D9B1A695" modified="2022-01-19" version="1">MSTVQHFNCCICGQESLTEADLQTHMLLDHEESAGSCPMCDLRHLTLEELNVHVNTAHSAVLSPGKTGQDHSRSFTGMKAPGPLNHCRISYGQELLENELMIRGCNLDVSKEGCANSEGEQQYESSFTNAVGAGQAVDRSEKIGGTGSESAKTSPDYSTRNKGIRKKSRPCACSFNAGRPGSGHPDNSETLQSNNKYSINGFAHPSCSDPSGKPDSVGDIKAPGQGQTSVLVERKRTRSKAQLNSPSASNSAVVVSCPADDSSDRLSLSSLTATASPLKKILRLFSPSKGNTCELAGKKVIQDTGEEKGRREADLSMNPGQDGNTSVPECPFCDATGLDSEAMLRHVEREHSDALASPHSTTKAAGDKNQWNTSMIQKAADLKPTLLSLSRQAHNLEMAITCPICGLGSYDPDFLTVHINTEHKLLDEEDRAAAVLTVPSSVPQDEAGPSTSANSHSERSVCPVCGMSGLNPKLLNDHVENHFEVGGQDSFSGDRQLARQLAEQERQLQERWQRETFKQLQAKYGMDEVGSYKQQSEKDLETAVVRGQITVTDYNQRKTSLQRSLAVGVDDGKSRTSGLVQKMVTYYTEKTIPGLSYAKLCCDADHYSSSYGDKGWGCGYRNLQMLLSSLVHIDDYRQVLFSGRNAIPSISKLQQLIESAWAKGFDLQGQEQLGGCLVNSRKWIGATEIAAVLSSLRAKCRLVDFHRPTGAGGTHPAMFEWVRDYFGKPRSSSLKLRVLGGHGPRGETIQTRKTPLYLQHEGHSRTVVGCEVHKDGSIRLLLFDPSYQVSDMQGLGLAKLDEYAMRPVRKSLAQMKSKQYQIVSVDRLMTSDQEYEQSKILQSERKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSH6</accession>
    <name>A0A8B7ZSH6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Cytochrome P450 2C31-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110988808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108364.1">
        <property type="nucleotide sequence ID" value="XM_022252672.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108365.1">
        <property type="nucleotide sequence ID" value="XM_022252673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSH6"/>
    <dbReference type="GeneID" id="110988808"/>
    <dbReference type="KEGG" id="aplc:110988808"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF20">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022108364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022108365.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="57363" checksum="B5750EA69F05FA26" modified="2022-01-19" version="1">MVVSAAVGGGAVTGVFTVTGTTIALGATALVLVVLLLLCLGGSSGGLGAESPPVAPGERCVSGHLGIMTGAQPSWITLNRIGKEKGDVMSLKVGHWVIMLNTFAAIKDAAINFVKEMGSRPTNYTTNLLSENGKDISLGEYSHDWLLLREMGIKNLREFTTNKRLEEVVHIILNKLEEDLDKKENQPVNVKDITIPATAGVLSHLCFGFDADASVHDRVAKLLSDGLFKYIVGPRLLANFIPILRFFPSNALREAQATVNELNGLLRSEMKRHQESLDPDITRDLMDGIIKCRNHARETEPDKYEFLTETHAYQVISNYLGGAAGALVVALQTGVALFVSNPEQQEKFSAAVTSVVGEDRMPGLDDQEKSVYVRATIEEILRYACIAPISVPHKTSEDITFRGFKIPANTGILVNFYGLHFNEEYWPEPFNFKPERFIDERGNFRSDEHMYPFGYGARSCVGQPVARQLMYLILSWLTHRYALCRVPGEEDRDLLQQDPDVQVVKAVPPFDLILKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSU6</accession>
    <name>A0A8B7ZSU6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Perilipin-2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110988685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the perilipin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108137.1">
        <property type="nucleotide sequence ID" value="XM_022252445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSU6"/>
    <dbReference type="GeneID" id="110988685"/>
    <dbReference type="KEGG" id="aplc:110988685"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010890">
        <property type="term" value="P:positive regulation of triglyceride storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.340">
        <property type="entry name" value="Flagellar protein FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004279">
        <property type="entry name" value="Perilipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF49">
        <property type="entry name" value="LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03036">
        <property type="entry name" value="Perilipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036881">
        <property type="entry name" value="PAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109775">
        <property type="entry name" value="Mannose-6-phosphate receptor binding protein 1 (Tip47), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022108137.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="50358" checksum="C5EC4FEC83687BEE" modified="2022-01-19" version="1">MFAVTGTQKTSQVTSESNENLGRNLVSMKTEATNPAAEPMETGPGNVVVLDSTPGVDIITRVANIPVVSSTIGQVANVYTWTKEKSTLANKALGYAEKSVVVAAQTAKPVVDHFEKPLTMASDFACYQLDKLEEKVPLISKPTEEVVATIQDGTRQVIEGTKQKGADGLNALMNTRVGKAVTFGLDTALAVSEFAVEYYLPPDDAERKQAIKDDYDEQEEEKRETPTSIQRVGTLTQKVRRRVHKKALANIRYAQKRSQETIQKLHFTVDLIDYAKKSIDGANQTIRTNAEAAQEKLWNTWNDWTTTEEGKDEKTENSEVENKEGEQKTMAIARELAARLRGLTHNVANSVAVLPQQIRGKVEEARATADSIYHSFEEAHYLSDVSTSMLNTCRDQLNNLSHVGMQVVDYVINSPPLQWLVPSELPNVEMEGIEFDYVPGSDQNDVDLTSDSSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVV3</accession>
    <name>A0A8B7ZVV3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box/LRR-repeat protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110989263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109222.1">
        <property type="nucleotide sequence ID" value="XM_022253530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVV3"/>
    <dbReference type="GeneID" id="110989263"/>
    <dbReference type="KEGG" id="aplc:110989263"/>
    <dbReference type="OMA" id="CIRSQAN"/>
    <dbReference type="OrthoDB" id="2153609at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF152">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022109222.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="17308" checksum="7FC3BA799C9E146B" modified="2022-01-19" version="1">MSELSKCSRCLLSLNLWRARNLTMSGLRALAEGFENLLEIDLGWCGQLRGPPFSPIFVNFVQSCRKLRKLFLPAVRSISNNDMHAIAACLPDLEQLDILGTLSVSVDGVQRVFESCPKMRFCDLSFCNSITDVDIVMLRQAHPRVTIQRSFISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZW97</accession>
    <name>A0A8B7ZW97_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC110989347</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022109362.1">
        <property type="nucleotide sequence ID" value="XM_022253670.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109364.1">
        <property type="nucleotide sequence ID" value="XM_022253672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZW97"/>
    <dbReference type="GeneID" id="110989347"/>
    <dbReference type="KEGG" id="aplc:110989347"/>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="134"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="314"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="484"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022109362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022109364.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="56817" checksum="C293494F01F346DC" modified="2022-01-19" version="1">MMAAAPPQSAEVSKMNNHGANSPARGADVNSQKMAPPTAGMAKMSIKQNQNGPSSNVNASSAKPATTNNSTGKSDSGDWKAGLKKPPRDARIKTSDVTNTKGNEFEDYCLSTGLLKGIFEKGWEWPSPIQEASIPMALSGHDIIARAKNGTGKTGAFTIPMLERTQVDKNEVQGLVLVPTRELALQTSQICKELSKHLGLQVMVTTGGTSLRDDIIRLQQTVHLIIATPGRILDLCRKGIAKLDKCGILVLDEADKLLSQDFKNMLDDLITFLPNDRQIMLYSATFPTTVKSFMQKHLPNPYQINLMEELTLKGITQYYAYVKEREKVHCLNTLFSKLQINQSMIFCNSTQRVELLARKVTELGYSCFYIHSKMRQEHRNRVFHDFRMGACRNLVASDLCTRGIDIQAVNVVINFDFPKLSETYLHRIGRSGRFGHLGLAINLVTEDDHQSLCLIEQELATEIRPVPSEVAIDKSLYVAEFQIPGGTGEGEDKKKSVSAVGSKAQPNKPKQAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWM3</accession>
    <name>A0A8B7ZWM3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransferase 1A1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110989615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109824.1">
        <property type="nucleotide sequence ID" value="XM_022254132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWM3"/>
    <dbReference type="GeneID" id="110989615"/>
    <dbReference type="KEGG" id="aplc:110989615"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="54"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109824.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="38674" checksum="DDF53FEC339B5886" modified="2022-01-19" version="1">MVDWQGFQKMVLSLPRIEPAVGECLEYYHRGVCVPKGVPRQVFEELESFQVRQDDIYLITYPKAGTTWMQQIISLIMDGLEAELHKKVHVFFRFPFLENTWISHYSQVGLIPPTHSLLPKMPCDTPRKIKTHLAPIFLPRQIFEKKPKVVYVARNPKDVAVSYYHMHQFDTTLQTYPSWEKFFERFINKDVCGGDWFEHNLFWWKKRHDSNVLFIKYEDMKKDLKSAVQLTADFLERPVTQKDIQKIVEKCSFQNMKKDPTANPDMVLEFGSDCEVLNQPPKEKMVSFMRKGQVGDWKKYFSVAQNELFDELYQKEVMGSELSFDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWN8</accession>
    <name>A0A8B7ZWN8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110989436</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022109507.1">
        <property type="nucleotide sequence ID" value="XM_022253815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWN8"/>
    <dbReference type="GeneID" id="110989436"/>
    <dbReference type="KEGG" id="aplc:110989436"/>
    <dbReference type="CTD" id="4249"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027833">
        <property type="entry name" value="MGT5A-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF2">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15027">
        <property type="entry name" value="MGT5A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MGT5A-like N-terminal" evidence="19">
        <location>
            <begin position="10"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="18">
        <location>
            <begin position="209"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF15027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022109507.1"/>
        </source>
    </evidence>
    <sequence length="802" mass="91840" checksum="68E47160ED5BC3DD" modified="2022-01-19" version="1">MLGRKCCRLITSSRIGIFLLFLMLTWVYAFMNYTLYRAQPGVRESDRLRQKILEDSELYVKALANEEREGLNAQNSGVVYDLKRTLAVLLENILQRLGTVEQKVDIIYTNGSQLFRNLTGFAAAEQKHAARSEAEEHQDGIYTNKRNKGGRKEPLDYAEEEEDERPVLAKDLIMQPEMKCSYLRDELRGYPDCERKIAWMREMWSSDPCYSKYGVDGSECSFLIYLSEVESWCPILKWRPQSPRPLLTGSNRPKATLRKDKEGLMAILDRANAVKLEWVKQRIDRMWNDKWIPAMEALQTKQNLTNREEKKHQILVHMGLLTKESGFKIAENAFSGGPLGELVQWSDILASLYILGHNLEVSVMYSSLKSFLKGKGVISQSCPIGGERPFDLVYIDIVGLKQFKKAAGPLWKQLNCMLRVIDSFGTEPAYNIRSYSKRTGRKTDWGGWELLPKQFFTMFPHTPDNSFMGFVVESNRYETAVPGTRDNKALVYGKMSYMWKFPGLENKGSSEDANAMKFLDIIHRKFEIHATVHIDQNKTDEVGAVPPYVHNHGILSGRDLQHLLLQTKLFVGLGFPYEGPAPLEAIANGCIFLNPSFDPPKSKANTKFFKNKPTDRELTSQHPYAELYIGKPHVQTIDIQNYTALQAVVDEISQSAAPPPYLPYEFQCEGMLQRLSIYIEKQDFCSRPKSWPPKSAMHVKVSDINESCNKRCMRDDLICEPAWFHLLNYRDVLEKNFRSSCSSLESMEEVFVPAVNPVRSSCKLQGRPLLYSCASQDRDLRRICPCRTYIRGQVALCKECIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXC8</accession>
    <name>A0A8B7ZXC8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110989846</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110989846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110203.1">
        <property type="nucleotide sequence ID" value="XM_022254511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXC8"/>
    <dbReference type="GeneID" id="110989846"/>
    <dbReference type="KEGG" id="aplc:110989846"/>
    <dbReference type="OMA" id="NSEAICH"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="693"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022110203.1"/>
        </source>
    </evidence>
    <sequence length="767" mass="87681" checksum="6BCCBAC107E1E6DB" modified="2022-01-19" version="1">MNVSMCPGGHKLVPWRSTGERNTARCPICLAHPIKEVFFQPTLRAREEFLRSLLFSVSRSNFPESLDVETVSSNLAKDKDWRNKQLEVMRGIQKALMMAKLQNKVTFFKKLTPDHIPVPLSEQRTVEWRPFVNLLIECGILDVVILLLKLRVSNPADEVDKLGDPWHAVYYFSLDIIANIMLSSYWENPKAKKFIHKIAQSEFVGAAMAFVDDTKHFLAMVLSIYNLCHIYEDHPQAGMLLARSPLLSKLGVFIHKDNSVRIMNRWMNQGIFNFQVEVMMENQAGLLPMRSTSVFDIGEPMEYTDEDIKDIGIQFASTLQQSSLQCIGYLAKHKQVRAVVVKDQFVGKAIGRWVRMPVLSPENRYMLEACVKVLAEMAYEESFAWKLLDEHGFMPLLENGVYYPEADVVWHYFEVATRIAMHRGLLIKRIVENPKIMRAAAIHMYSLDININIYATALLALAVDNPGVEYIIKYFGPKHFYHYPSYFFSKTPKIGIKIDELQAGCRRYGRKEFDKAQKEFRKMRNQTLDSGKATQLKEGGNEMYKSGEIQEAIKLYTRALNVCPPSIPVKTAPNFLLGAMPQWSSLPATLFSNRAQCYLNVGEYELAVEDCDEAIARCFGGTCPEDPTLADTIRLKAMFRRSKALFELGKYFRAVQDAGECQINQPSETFKAHLDKVMMRFRNIMGMDPVQRCDECRQTNGFKLKRCANCMALYCSKKCQEVAWVRRHKVNCQEYQVEKEAKKNKATADGTARAMARASCNGSTDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXQ6</accession>
    <name>A0A8B7ZXQ6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110989928</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022110328.1">
        <property type="nucleotide sequence ID" value="XM_022254636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXQ6"/>
    <dbReference type="GeneID" id="110989928"/>
    <dbReference type="KEGG" id="aplc:110989928"/>
    <dbReference type="CTD" id="9252"/>
    <dbReference type="OMA" id="VEMIYAF"/>
    <dbReference type="OrthoDB" id="6764942at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14092">
        <property type="entry name" value="STKc_MSK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000109">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000157">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="36"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="16">
        <location>
            <begin position="306"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="414"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="732"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="767"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022110328.1"/>
        </source>
    </evidence>
    <sequence length="953" mass="105399" checksum="2F404A5772F7826C" modified="2022-01-19" version="1">MEVPGTSGDEALQVRRYELTNANLTNHAEKVGRKSFELLKVLGTGAYGKVFLVRKHSGNDAGRLFAMKVLKKATIVQKAKTAEHTMTERQVLEAVRRCPFLVTLHYAFQTDSKLHLILDYVSGGELFTHLYQRERFLESEVRIYIGEIVLALEHLHKLGIIYRDIKLENILLDQDGHIVLTDFGLSKEFLPNTDSRAYSFCGTIEYMAPEVVQGGTTGHNKAVDWWSLGVLTYELLTGASPFTVEGEKNTQSEISKRILNSYPGMPSSFSPTMKDFINRLLVKNPKKRLGSGPNGVQEIKQHPLFKNLNWEDLAAKKVPPPFRPHISGELDTSNFADEFTNLPPAESPAAVPKTADARVFRGYSFIAPSVLYSENAVTADLLRPEPDKNKPSPEQISNSSKIKESVFHKTYEIDLKSEPLGDGSFSVCRKCTHRKTGQAYAVKIISRRKNCSQEIKSLQLCQGHSNIVQLNGEFKDELHTYIVMELCRGGELLNRIRKKKHFDEAEASTIMRKLVSAVDFIHNRGIVHRDLKPENLLFTDETDEAELKIVDFGFAHITNANQPLKTPCFTLHFAAPEVLGQTIDKDGGYDASCDIWSLGVILYTMLSGHVPFQASRRSGDNSALEIMRRIKDGNVSFTGQHWSSVSEAAKDLIQGLLTVNPSQRLTIEDLLINEWIQGQQATSSTPLMTPNILLSASTSAVQTKVKATMFAFHRAQREGFRLLDVSNAPLAKRRKLKKDSSTETRSSSSESTHSQGSSQGGRASPTHFPNPNTRNANPYLVRTDVPSAQQHTGEGSGDDPFDRHFTEASSTKNSKQDQIVPALSHGVASSTCSAATSTVHSQGHCLPASLQGINPVHRHLQSNASLDANPLLFIPSIPSHHPTHPQLLAFTTVNSNLPQAQHPATQGHHPAQYSTVSFHHLPTIQENLSQWQAIIGPAGNVATTIAPVLPDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXW8</accession>
    <name>A0A8B7ZXW8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110989972</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110388.1">
        <property type="nucleotide sequence ID" value="XM_022254696.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110389.1">
        <property type="nucleotide sequence ID" value="XM_022254697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXW8"/>
    <dbReference type="GeneID" id="110989972"/>
    <dbReference type="KEGG" id="aplc:110989972"/>
    <dbReference type="CTD" id="8891"/>
    <dbReference type="OMA" id="NCVINPK"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04198">
        <property type="entry name" value="eIF-2B_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="11">
        <location>
            <begin position="354"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022110388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022110389.1"/>
        </source>
    </evidence>
    <sequence length="463" mass="51208" checksum="ED86949AE596BF8C" modified="2022-01-19" version="1">MEFQAVIMAGGRGSRMPDLTASVPKALLPVGNRPLVWYPVNMLDKAGFESVIIVTFDSVKRDLVQALQSSAGELLIRLDVVTIPSDEDWGTAESLRFIRDKIKTDVLVISCDLITDIELHLLADVHRTYDASMTMLMHTTLDQSNEGGVSVPGTKSKRKTEQRDIVGLDDKGSRILLLAAEADVEEALSVKKSVLKRYPFIQVKTRLMDAHMYILKKWVLDFLGDNKIGRTYSTIKGELIPYLVRKQFSRPKTGQLGPQLDSMESVALQQDKDLSSYGGLDDLTKKARAMSSWNEHSGDMSDYYQHGDTLRCHTYIMDSGFCIRANTLAAYCEANRQIPQQRQLVGEDPLIHPTATIKTKSQVGQDSMLGEGTTIGEKVSVKRSIIGKHCIVGDKVKIINSVVMDHVNISEGCTIQGSIVCGNTHVSEAVEMKDCLIGSSQNIPPKAKYSNEVIGNADRMMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYC9</accession>
    <name>A0A8B7ZYC9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Plectin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110424.1">
        <property type="nucleotide sequence ID" value="XM_022254732.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989986"/>
    <dbReference type="KEGG" id="aplc:110989986"/>
    <dbReference type="OrthoDB" id="6162046at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031440">
        <property type="entry name" value="DUF4670"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21937">
        <property type="entry name" value="CCDC66 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21937:SF5">
        <property type="entry name" value="GENE 973-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15709">
        <property type="entry name" value="DUF4670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
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            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
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        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="780"/>
            <end position="789"/>
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    </feature>
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            <begin position="811"/>
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            <begin position="1082"/>
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    </feature>
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            <end position="1139"/>
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        <location>
            <begin position="1141"/>
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            <begin position="1166"/>
            <end position="1192"/>
        </location>
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            <begin position="1212"/>
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            <begin position="1235"/>
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            <begin position="1295"/>
            <end position="1309"/>
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        <location>
            <begin position="1316"/>
            <end position="1444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022110424.1"/>
        </source>
    </evidence>
    <sequence length="1560" mass="174320" checksum="30C6FD24B11F455D" modified="2022-01-19" version="1">MATVNTGFSLLARGIGEEKVHRGHRKLEVSLEPEDYHNIQGRKFYLPPIQQRAWPQEELDSPRELHTHKTFTTRKGALLLYSEDLALTAKERAESNKALEAEDTLNLNTFHDLRSAILSYGAKDASSEPVYLGFVHNKHAPTTHRAVRPGFSAKRYLSNWSRSWDDSILNTLRNNGHILDKNLFQENALAPKILRRINDDLSGLPAPYRVTRNMLMAPGSPIIYEFYRVRPSSADSGSSLSTEERLKRKLRRPSEDDFDTDREGRRTPMVSFNIPGSIAAVVRDEQNKPHAVPYSSLAPDEQQQVLQRLLLQSAMHKQLLEAAERTGQELGSNTSLAGSRPVTVEKIKKLNMGNAIATLVDTNTSGLLQGQQVFDDKGFKELYKRKFGQQAEPSPPTIRKGLTHSARRSHFPSVPTLPPIVSSSPTFKPAERQTLKLDSKLPQITMEPPTPQHPVLSNNTQSQQNSSWGQESEDFRESWPSDETNIWKADIDEEELLKQQQAASEEEGDEEDDREEELHRSETKTKSARSTRSLGQGRTPSKPASILSSVSVSMEDLTGPIISGASKHQSSSEKSYGGSSSEAGRSIKGSQLPGSLRESMRSYKGGRNSNMGSVVLGPDGEILSIGGGVGMGSVADAGSSVADATDNLQASSMAHSTHMGELESLDELDEQEDDTLSQDSGHMSSEEVEGHDPTPVPQPVPIPTAQFGDDLPESKPPSLPSLPLSKPTRSQKSAEESVHLAREIDITGGDLDATRSFANFSYGSVGQESVAEDALSQDGIDDHGEREAAADDDIMSEQEPDWPTEFGETSELAEEDALMEEPEKEVVNEEEKEPSTTGSVKDEVASQRAPSQLEELEEHAAVVAAMVLERPKSGRDLAEDAEAAATLWAKKLGELFNLSGDPERVQSALVRRRRNSLDASSVASSTEHGQWAGPTLKKKPSKKSRKLKRIHSAEAAVNFLKNLVKAGGDAGDATSVHSGKTGKSLHSAGSRVESAPTVKSGKSAAAKSTPSVKGDAGAPLEFGVTNYGVADKKEQEKQPPIVRPPAEPTKPKELDTEDEELAKILKETGLMEKEKAPDAKSTKSSKSSKSNKSNKSSGSKDKNKEEFVVKKPEDDKVDHLLYKPLPEKKPEEKKAEPAKATKAKKPKKPAPVKKVSPAKKPKKKLKAEAVKEEPKPPPEETSKAEEEKKVEEVAEDAESEDVKLSKTPAMEETAEEDEMDEEEEEEKAESPEFIIIHDIERENTEPVIEKTEAPVIPVQQRKEFSDSEEEEPEPLPPSVAQTDMTADSELMSVYTEDSTSQGLSGISRSQAKAAKRAAEAERRKQAVERKRREREEAKRKQQEEAERQEQLRRDFEEEKRRKEEEIRLKREREAEELERRRREEEERKRQAAITAEREKKRMEEYKRKMEEIARQKREEEERKREENLRKQKEEDERRKAEEAKLAAMAEEERLEYERKKREDELIAMRLAEEERLKRELLAKLAQEEAERFALELAKRQKEMERRLMFNKSLQSEANVLSHSQEMTRAFTWSYFELLEFLGLAMPDFLKQYQSYTDTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2M4</accession>
    <name>A0A8B8A2M4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990841</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111622.1">
        <property type="nucleotide sequence ID" value="XM_022255930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2M4"/>
    <dbReference type="GeneID" id="110990841"/>
    <dbReference type="KEGG" id="aplc:110990841"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111622.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12036" checksum="3BE8D13E44A18168" modified="2022-01-19" version="1">MHALISILQGPKHTPRARIPPRTDERLKQFIEGVLEDPERSAAKTLENWPYYLEEDLDSVPAVMDDEGLDEASIGVQTLPDENPRPCEPPRAEWDDTDMSGFFDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3A3</accession>
    <name>A0A8B8A3A3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Neuronal acetylcholine receptor subunit alpha-10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110989948</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110366.1">
        <property type="nucleotide sequence ID" value="XM_022254674.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110989948"/>
    <dbReference type="KEGG" id="aplc:110989948"/>
    <dbReference type="OMA" id="MNPLFFP"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000016">
        <property type="entry name" value="Nicotinic acetylcholine receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034227352" evidence="17">
        <location>
            <begin position="26"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="18">
        <location>
            <begin position="33"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="19">
        <location>
            <begin position="247"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="395"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022110366.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="56328" checksum="43B0AA044DB2957B" modified="2022-01-19" version="1">MGRMTRLAPFTLAALFLAATTCIHGQSMEPQEYELVTHLLQDYFPLVRPVANHRDVIDVFMDMTLVEIVNMDEENQIMVTSVRMYQQWRDVNLQWDPKNFYNITQITLPSTAIWKPDIVLYNNANDNLEGGIRQTRALVDSDGTVTWKTLAILMSACEMNPLFFPFDIQNCSLKFGSWTFHGDQINLQLNVTSADTSMFQVNGEWDLIGMPATREVSYYPCCPEHAYPIVTFYVLLERRSLFYMVNLVLPCVLIASIVLLGFFLPSDAGEKITLTITILLALTVFLLLVSETIPPTSEVIPLIGQFYASIIVLVGICAALTVIVLSIHHRGDSTHVPRWVHTLFLVKLATLLRVRNQISQSSMELELHGPSEADVSSVSPRGGVLNPIFEGDDGIEEQHQQQDDGAERRRSLAEKEGSAMERQLSTGGDSSIIEQYITSISKNVSYFVRQGREEDKSQKIATEWQEVAMVLDRLFMVVFTFLIALVALSTLLAAALRVPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A6C6</accession>
    <name>A0A8B8A6C6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110990749</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022111536.1">
        <property type="nucleotide sequence ID" value="XM_022255844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A6C6"/>
    <dbReference type="GeneID" id="110990749"/>
    <dbReference type="KEGG" id="aplc:110990749"/>
    <dbReference type="OMA" id="TIYRMEM"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034064955" description="Gamma-aminobutyric acid type B receptor subunit 2" evidence="13">
        <location>
            <begin position="19"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="15">
        <location>
            <begin position="73"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="476"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022111536.1"/>
        </source>
    </evidence>
    <sequence length="672" mass="75627" checksum="9140F86A8C381E55" modified="2022-01-19" version="1">MITKGLLVLMFSLANGLALFAVHVKGATPNSDTEATGDNVKSLSGEFQQRIPIYIGGFFALPNNSIFGALPSTVQTAIDHINNLTGILDGYKLKMRYRLTNGLPNEALGFLNDLLYEGPTILMAAGPIFSRQALVVNEVAPRFNVVQVCLANSQALRDRERYPLTVQMYWSEDSVNPARVAFVRYMSWRRVAIIFEDNEYFRTNAEDLRAKLEAAGITVRATEAISDSSKPDQQLRSLKRHDARIIFALSYFDTAIKLFCTVFHMQMFGGKYVWTLVGWYPEQWWTAVDNVDCTAEQLQMALEYHFSVSAWRSVDDLGEIHYGEIQPPEYQLDFLRGLLAKEGVDRLEHIESYDVLVHIAMSLNRSIERLANLNPPKALHEFSYTDSEMSQVLLESVYLTSFVGPTGSVLIEDGGFRSKKNVRFFILQFRDGRSTEIIEYDDGSSSFRAVENRKLHWPDGSPPVDGKTIIIKNGEVSQPVQLTLFVFASVGIALDTVFLFINIKFKRQRAIKISTPPLNNLIVLGSLLLYTSVFLFGLDQSIFTDKEIIRICLIKYSLMCIGISLAFGALFMKTYRIHAIFSRAVAKLKRVVITCSKLTGFLTLFCYRMEASLWPGSGFLSLCPTANLRQESQLSRGQVKRVIEQEASSTENVTVKSYGSTNTRSVPCSWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-07" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L685</accession>
    <name>Q2L685_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">NADH-ubiquinone oxidoreductase chain 4L</fullName>
            <ecNumber evidence="3 15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">ND4L</name>
        <name evidence="18" type="ORF">KEG27_p10</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="16 18"/>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2006" name="BMC Genomics" volume="7" first="17" last="17">
            <title>Complete mitochondrial genome sequences for Crown-of-thorns starfish Acanthaster planci and Acanthaster brevispinus.</title>
            <authorList>
                <person name="Yasuda N."/>
                <person name="Hamaguchi M."/>
                <person name="Sasaki M."/>
                <person name="Nagai S."/>
                <person name="Saba M."/>
                <person name="Nadaoka K."/>
            </authorList>
            <dbReference type="PubMed" id="16438737"/>
            <dbReference type="DOI" id="10.1186/1471-2164-7-17"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="16 18">Tube foot</tissue>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="NCBI Genome Project"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="18">Tube foot</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="18">Tube foot</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3 15"/>
    <dbReference type="EMBL" id="AB231475">
        <property type="protein sequence ID" value="BAE79169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_492656.1">
        <property type="nucleotide sequence ID" value="NC_007788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L685"/>
    <dbReference type="GeneID" id="3907683"/>
    <dbReference type="KEGG" id="aplc:3907683"/>
    <dbReference type="CTD" id="4539"/>
    <dbReference type="OMA" id="MYRSHLM"/>
    <dbReference type="OrthoDB" id="6146597at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030964">
        <property type="term" value="C:NADH dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434:SF0">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 15 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 15" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <keyword evidence="12 15" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="BAE79169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="YP_492656.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="10733" checksum="FD68D5F8A21AD8B5" modified="2006-03-07" version="1">MTPIFISTISIYYLGLLGILINRLHFLSILLCLELLLISLFLSMTIWALNTGTNLFVANNLILLTLSACEASAGLSLMVALSRTHNSDLVIALNILQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGB0</accession>
    <name>A0A8B7XGB0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl-CoA dehydrogenase family member 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27 28" type="primary">LOC110973044</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates in beta-oxydation and energy production but could also play a role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 2,3-saturated acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44704"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44705"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>docosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47228"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65059"/>
            <dbReference type="ChEBI" id="CHEBI:74692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:47229"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hexacosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexacosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48216"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:64868"/>
            <dbReference type="ChEBI" id="CHEBI:74281"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:48217"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>tricosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tricosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48220"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:90118"/>
            <dbReference type="ChEBI" id="CHEBI:90119"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:48221"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079162.1">
        <property type="nucleotide sequence ID" value="XM_022223470.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079163.1">
        <property type="nucleotide sequence ID" value="XM_022223471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGB0"/>
    <dbReference type="GeneID" id="110973044"/>
    <dbReference type="KEGG" id="aplc:110973044"/>
    <dbReference type="CTD" id="84129"/>
    <dbReference type="OMA" id="LHGGHFE"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01155">
        <property type="entry name" value="ACAD_FadE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000018">
        <property type="entry name" value="Acyl-CoA dehydrogenase family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF13">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="23">
        <location>
            <begin position="38"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="25">
        <location>
            <begin position="387"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="24">
        <location>
            <begin position="510"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="22">
        <location>
            <begin position="624"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022079162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022079163.1"/>
        </source>
    </evidence>
    <sequence length="784" mass="88393" checksum="8CBC8E7DF6BBC7A1" modified="2022-01-19" version="1">MEDTSEVRKQHRFDEQKLHSFLMRKVPGFPQSSTQLQVRQFTSGQSNPTFYLSKDGCEYVMRKKPPGRLLKGAHQVDREFRVQQALHKANFPVPTPLAYCSDESVIGTDFYVMSFVKGRIFRDVTLPDKSPAERKEIYDALNATLAHLHSLDWRQLGLQDFGKEGNYCRRQVNTWGRQFRGATKLASLPDNPAAEQLLQWLVDNQPILEEKTTIVHGDFRLDNIIFHPTLPKVLAVLDWELSTLGEPLTDVAYVCMLYHYPHNMPIHLTNPKQDKFSELKRIRGIPSEADFVRAYCQRCVQPYPVPHWQFYLALCLFKMASICQGVYCRALLGNASSQFASNYKEIVELMLSLGLDQTKRLLSVAGSPTSSIILEMKPILESQPISERASQILQKVKDFVKNEILPVEKKYLEQVQSGDTIWCVPPIMEELKAKAKAQGLWNLFLPGVSGLTQLEYAFMAEAMGQTFIGSEPFNCSAPDTGNMEVLHLYGSPEQKRTWLQPLLDGTMRSCYCMTEPDVASSDATNMECLVVRDGDSYVINGRKWWSSGAGDPRCKVAILMGLTPNKDKSRHRQHSMIIVPMDLPGVKKIRPLTVFGNPDAPHGHLEVEFTNVRVPASNMILGEGRGFEIAQGRLGPGRIHHCMRAIGMAERALEMMCDRAIKRKAFGKELARMGVIQHQIAECRLEIDQARLLTLKAAHTIDKYGTKEARKQVAMIKVVAPRMLTRVIDQAIQIYGGAGVCQDYPLAAFYTGARTLRIADGPDEVHLTSIGLQELKEQTVQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGM3</accession>
    <name>A0A8B7XGM3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Ras-related protein M-Ras-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15 16" type="primary">LOC110973416</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079938.1">
        <property type="nucleotide sequence ID" value="XM_022224246.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079939.1">
        <property type="nucleotide sequence ID" value="XM_022224247.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079941.1">
        <property type="nucleotide sequence ID" value="XM_022224249.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079942.1">
        <property type="nucleotide sequence ID" value="XM_022224250.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079943.1">
        <property type="nucleotide sequence ID" value="XM_022224251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGM3"/>
    <dbReference type="GeneID" id="110973416"/>
    <dbReference type="KEGG" id="aplc:110973416"/>
    <dbReference type="OMA" id="DRDVYPM"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022079938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022079939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022079941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022079942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022079943.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23493" checksum="E065B07DF57FF7A1" modified="2022-01-19" version="1">MSNALQDMSRDNLTTYKLVVVGDGGVGKSAITIQFFQKMFVADYDPTIEDSYIQHTEIDGEWCILDVLDTAGQEEFSAMREQYMRKGDGFLIVYSVIDKASFENTKSFYTQILRVKDRDSYPMILVANKVDLVHQRKVTEEEGKALAAELGKTSYIETSAKDPPQNIDRAFHEVVRVIRRQPVDRDAKRRSRRGKRGAKQQNCAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XH13</accession>
    <name>A0A8B7XH13_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">WW domain binding protein VOPP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Vesicular, overexpressed in cancer, prosurvival protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110973518</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endomembrane system</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Late endosome membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VOPP1/ECOP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080088.1">
        <property type="nucleotide sequence ID" value="XM_022224396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XH13"/>
    <dbReference type="GeneID" id="110973518"/>
    <dbReference type="KEGG" id="aplc:110973518"/>
    <dbReference type="OMA" id="FILMTCC"/>
    <dbReference type="OrthoDB" id="6629737at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026229">
        <property type="entry name" value="VOPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14971">
        <property type="entry name" value="VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14971:SF2">
        <property type="entry name" value="VESICULAR, OVEREXPRESSED IN CANCER, PROSURVIVAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034560798" description="WW domain binding protein VOPP1" evidence="19">
        <location>
            <begin position="24"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="152"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022080088.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25034" checksum="3FA0D34044B27686" modified="2022-01-19" version="1">MERISTEGVLLTIFLVFIAQVYGEYCPDTDNVYCDNDEYCCDSSCCPLTYENYGFWNIWYFWFIIFFILMTCCGGCGFYRRRQAYLNQQNSTIITSQPVVVPPPRQQNPDMVGAYPAQPVPQGAFQGPPSYNEAVSKPHLYPKSEAVYPPPTMPMNGAGASPNPAYPPDGAYPNPVYPPQTTYYQSGMPMPQPDGPTSPTTTPMPAPPPYSAAAASDATQANAPPMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHC4</accession>
    <name>A0A8B7XHC4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110973593</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080198.1">
        <property type="nucleotide sequence ID" value="XM_022224506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHC4"/>
    <dbReference type="GeneID" id="110973593"/>
    <dbReference type="KEGG" id="aplc:110973593"/>
    <dbReference type="OrthoDB" id="9940536at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080198.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38746" checksum="BADC45BDDFE54317" modified="2022-01-19" version="1">MGGCNQSKVLLASSPADDFSSGVIKNKSLSWKFLKNCPNRIRVAPALPEDQQTTDVPRRAIVDINKPPSPIRSRLRASHDNGPSPTFSEVSLSPYMITEDTADGDELLELETAERPPTPDLCILGTPLFAKKISNKKKLHARQESQEILCELRNAGIVVRPETRAGGVAYEYFVKEKFGLLKKPPARLEKLKKAKKMREARGDAKLREEIDSRMQIAEERRKNVLDKVRIQQTQHLVLDIRRARDNSAALEEEKMQATAERLQQKEIMSQVMQGRATVNRDLRNMQKKHHHTEVRLRAALNKTAKKDEELCEARKIIVVSPMRGVEQDQSEEEEMAGEPMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHE2</accession>
    <name>A0A8B7XHE2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Protein sidekick-2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110973604</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the sidekick family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080214.1">
        <property type="nucleotide sequence ID" value="XM_022224522.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973604"/>
    <dbReference type="KEGG" id="aplc:110973604"/>
    <dbReference type="OrthoDB" id="8923679at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004908">
        <property type="term" value="F:interleukin-1 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000107">
        <property type="entry name" value="Myosin, light chain kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000158">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000206">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000209">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000360">
        <property type="entry name" value="Sidekick cell adhesion molecule 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004074">
        <property type="entry name" value="IL-1_rcpt_I/II-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF46">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01536">
        <property type="entry name" value="INTRLKN1R12F"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1937"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="52"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="153"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="238"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="330"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="424"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="511"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="608"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="709"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="811"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="914"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1012"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1112"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1216"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1316"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1414"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1513"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1613"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1719"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="1818"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1905"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1979"/>
            <end position="2096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1911"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2048"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2066"/>
            <end position="2080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022080214.1"/>
        </source>
    </evidence>
    <sequence length="2164" mass="236740" checksum="6AA50E24F2729FBA" modified="2022-01-19" version="1">MTDTSDNNRGLSQNSLCQRCVNSRSCCNQQSWVLTAWFLYSCFCIASSAVPPFINRHPQGDTAFAGNTELLSCQALGDTPLEYQWLKDNLILGNYDAQGAAYLLRNIQRSDAGEYRCRVRNDIGTVMSKRAVLHVAYFDSFVGGDRTEIATAGQAVILSCPDVDSFPAASIKWRKDGDDVSSDNKIVTIDNRLVILDSSSADEGVYTCLAKNDFTQESRVSPSITLTVQGVNPPSIVPSIVVPPRDTVFIQGDSIANMECIVNARPLVDLSITWKRNGVVLQTGGTEAFTYQIRSPSQSTKGVYECEAAMPSGVSVRATANLTSYNRGPPTFVNPPQQTTISSVGSDVTIPCEAAGTPRPIVTWFKNTVDVTTLGLSRFQVLDSGMLQITSTEAVDAGMYQCVISNEAGEDITDTWLQVREIAPTFTSEPQDTTKIEGEPAMMSCQAVGAPKPTITWLRDGSTPVPDDLIQDNGDLFFASTVASDTADYMCVADNGVGTINVTARLTVYIPTVIQTPPHDTKVQLSLPAVIDCVVQHDPAVTVTVLWYHNTALVDTDASSRVNLLASGSLEIRQTLRSDKGTYECVVTSVAGNGRRNATLTIQELPWKPTNVASRISPSDSRTVELSWVAPFDGNSPLLRYIIEQKEDESAFTVIDSSVDPSLPSFNVVGVIPSRSYQFKVRAENILGAGEKSDPTLVLHIPEEPPDEAPNSVVTSSSSTTSIIVEWQTPPEDTWNGPLRGYILRYKLYGYTSTPYTPVNITSVRQTSYTLQGLEIWTRYEIQVAAYNGAGVGIYSQSLAQRTKEGVPSEAPRNVQTTVLNSTAIQFQWQMPDPQTINGINQGYKLHAWLNGSESSKIEVIVDPNPAITILEGTISGLKKYTEYKTSVLCFTSPGDGLASPTVTVRTHEDVPGSVGSLKLKDVVDTSLKVEWTVPTETNGVIRGYEIKWYRYNTTSTSPPISLPPEQREYTVTGLTATTRYTLVMWARTSVGRGPPKETSFSSGVPPLRPDPPSQLAISNIQSSSVHLQFEPGFSGHTSISAWIVEAQVGTSTAWLRLYEHQDPDSRGFPVPNLIPYMDYVFRLRAQNIAGESEPSQTTRRIQTLQDTPEIAPREVTVRAHSETSLRVRWVPLLKREWSGEPIGYHIYWQEVNAVTPDPTQGSYDLLEPYTGEYVIAGLQEWTEYSVQVQAYNEIGAGPISDGLVGRTTDTVPSSGPSNVTARATGPFVIDVTWGPVPKIDQNGAILGYKVRYYATSSPSEQLTLDVTGEASMNGSLSGLRGYTRYALSVLAYTRMGDGMVSSTVVVETQESVPGPPSGILFPVVTNTSAKITWRAPVEPNGIIQSYRVSYVQQGFPDNFKQTTEVGMAQEYTVSNLFDNTYYSFSVAAKTRLGWGQEASAIVITTNDRTAPTAPSKPSVDYIHSRDARISWTPGMDGNGPLRFYSLQIKEGAGSFLDRATHIDPGVISYFVDKLSPYTDYQFRLKAHNDVGPSPWSEESDVISTEQDVPDGEPGIQEVTPITPTSVRVIWTAPPISTHNGPLEGYRISYTELPDGSPVERASTDPSLLQYELANLLRYQDYEIKVRAYNTKGAGPCSRPVTVYVGVAIPSAAPSNVMASASGASSLRVTWEALPEEAKNGGLQGYKITYWETPSEARSARETPIKYTKTFPSEDTEATLDGLKCFTEYSLTVIGFNSAGDGPASDEITSVTEQSVPGIPAAVGFQRIRMTSLNLTWAPPELPCGQIKGYQVYYESITPIDGEISTITVEINGPLLTYGVEKLGEFATYTFRVKARTDGRSYGPYREANVTTGPQPGMPGPPGALYLEAEVDSFKLSWTRPEETGASQLIGYILESQEEGRSEWETQTDSVSPDALYYNVPYGNLKTSTRYKFRVMAENQQSISFPKATSELKQTPAGENTEQPDPGLTQKMFYEEWWFLVIVGLVVLIVLILITATLCMLGKSRLYKERKAHSRVNLDDPVSIHDGNLSDTFEMQQGNGTNGRSTGGRGRGRGRGGNRNGIYSRTNSYTRPPPRPSPGSIQYSEEEESKHYEAVHRQPSREQDETSSLTEKADLQSQTDSQSSCGSKGSESDIEYTEDPHSFVNHYASVPASAYPSHSWKRQKGPKAYSYTDSESDMHSIHINGLAGMPAGSRAPLHGFSSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJE1</accession>
    <name>A0A8B7XJE1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Inactive rhomboid protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110973621</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080247.1">
        <property type="nucleotide sequence ID" value="XM_022224555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJE1"/>
    <dbReference type="GeneID" id="110973621"/>
    <dbReference type="KEGG" id="aplc:110973621"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050708">
        <property type="term" value="P:regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000025">
        <property type="entry name" value="Putative rhomboid family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022241">
        <property type="entry name" value="iRhom1_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF3">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12595">
        <property type="entry name" value="iRhom1-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="785"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="903"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Inactive rhomboid protein 1/2 N-terminal" evidence="11">
        <location>
            <begin position="88"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="10">
        <location>
            <begin position="750"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="108"/>
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    </feature>
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        <location>
            <begin position="158"/>
            <end position="173"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF12595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022080247.1"/>
        </source>
    </evidence>
    <sequence length="958" mass="107572" checksum="8BB9B3ED7D4C31A2" modified="2022-01-19" version="1">MSLPSSIVEEKKGNRVSFLDAEREGTRSSNAWGSKGEESGSRDSGEEERSVQLEEDLEGSEENLLEQNTSRVKSVTANFFGIGDNANEDQRRWQSRRSRHLSRRHGGVKPHVEDDLMDREVMAMGNMTPLPHIIDPLARPRMRTAMDETDGARQPLNSAMSSATGGSSVFTKQVSHRLTRQRSKRQSVAKMGWEVLRQSVRQPKTAPKQSVSQDCLVQQRPPLLHSRSFAPASLVIGDYEEEDEMDTVPFFSPGVVSDDLTDDVFFSTMSPKRERQSPVKKTQPAAAAAAAVTCDLTDEDLKLKEAVSLPTVMEAETESEGATSKKPSVKEIKGKISASLPQLPVPETPEELLAETPMPEPTPEPLQEPSPNEPIQPTPDTQEVPVVLRGRPLPSLPPERVPSAGEPLDGRVAVAIAQMIPTGIGWRKRKTEDKFRMAPILAEDAPDAIMPAIRRNKIAEKIMQGAFDNSDRRQIGKGLVGRVLNRSYKSRRMDSNVRKQIEEIEDHRPYFTYWVTTVQIVIVIVSIAFYGFAPIGFSYSQRTELVQQSNLVVQTVGYMEPDNFWIGPRPADLIHLGAKFSPCMHRDRQIHQTIDDERQKESTTGCCVRTDKSGCVQSLQEDCPTRFSNFIKWPDTTDPENDRSSGPVCGQDPRSCVKPASVPPYEWEDDISKWPICWESLEIPDKEHTTCDVTGRPCCIGIYGTCMIVSRDQCDFVNGYYHEEATLCSQVNCLDAVCGLVNFANPEYPDQIYRIFLSLFLHAGIFHCILSVIMQMTILRDLEKLAGFFRISVIYIFSGIGGNITSAIFIPYRAETGPAGAQFGLLACLVVEVLQSWQILKSPFKALAKLLFIIALLFVLGLLPWIDNYAHLGGFICGTFLSFIFLPYIYFGEFDRNRKRVQILVSIFLLLAYYCLVFTVFYLRLLKDCSWCQFFNCVPLTDDFCNDMDLRLDKIPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJM7</accession>
    <name>A0A8B7XJM7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA excision repair protein ERCC-6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent helicase ERCC6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Cockayne syndrome protein CSB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20 21" type="primary">LOC110973686</name>
    </gene>
    <organism evidence="18 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20 21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080379.1">
        <property type="nucleotide sequence ID" value="XM_022224687.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080380.1">
        <property type="nucleotide sequence ID" value="XM_022224688.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080381.1">
        <property type="nucleotide sequence ID" value="XM_022224689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973686"/>
    <dbReference type="KEGG" id="aplc:110973686"/>
    <dbReference type="CTD" id="2074"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21397">
        <property type="entry name" value="cc_ERCC-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000863">
        <property type="entry name" value="DNA excision repair protein ERCC-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000042">
        <property type="entry name" value="SNF2 family helicase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059240">
        <property type="entry name" value="cc_ERCC-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="664"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="992"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="88"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="340"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1180"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1221"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1379"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1430"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1484"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1190"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1249"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1266"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1392"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1488"/>
            <end position="1506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022080379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022080380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022080381.1"/>
        </source>
    </evidence>
    <sequence length="1579" mass="176599" checksum="CAFACE42C26A642B" modified="2022-01-19" version="1">MALPNQLAVEEGRSTGSALSDNAEVDNSCNRQDVGLSADLQNGLDRMEEQEYPMQKMTTSHITLDGSGVLTPTASPLLSTLTTSALKSDYTSGETQSTDKATTSGTPSVSGHCDPSTPTMSLSEKPLASTSDQRADCVDQDAPSTSRKDKDVFTVDTSLIPTVPDRLQATELQGLEGVSVFNQEEFERGVMQQVDQAISLRQQAADRERAEKDLDRVLTDIRSCKKELSHIDRMVSIANAKASISPLTFAQKEVQRNLISMRSKRENKAKQLKTLRARQRSLLAKLSGSDIGLQMSDDEADNEDRNVQTYQHFLCSSPSSDGVPSKPAEETEQERLIRLGEMTPFGSTVQSKASTSKTSAPKPMTDFEKFMAQKTEDDMTRRRKVLVRKKTPVKVKVESAKPRTPEQKAQGETLSRKIPSSKSKAWSKFEKKCIESSGKRKSESSKKETVRKASQSKEESVSDSSEDETYFVYKPVRSESSSQPKARVRSRKANRDLRPHWGSDEDLSDYYDENDADSAGSDEEYTPGFDDLSQPSDEDDVHSSPLKKRTKRRGRKAKVTTEDFEDGTIACLDDLKRAYGVNVKRSGGQRKSKCKDDATQDMYYRRLKEHRRSELRKKQHRIEQGDIDSDSEPEDMQFDGGLTIPGKIWSKLYKYQKVGVKWLWELHQQQAGGIVGDEMGLGKTIQMIAFFAGLKASKLRNPGSRYIGLGPVLIVCPATVMHQWVKEYHKWLPEMRVAILHDSGSHTGTKRALIHDIALSHGTLVTSYSGVRLREELLLKHDWHYIVLDEGHKIRNPDAAVTRTCKQFRTCHRIILSGSPMQNNLRELWSLIDFVFPGKLGTLPVFMEKFSVPITIGGYSNATQIQVQTAYKCATVLRDTINPYLLRRLKADVKQNLQLPDKNEQVLFCRLTEDQIQLYKEYLNSKECQLILNREYQVFAGLITLRKICNHPDLVSGGPKIIKGDKSAEAIEAANDPAMQYGYWQRSGKMIVVNSLLKLWHNQGHRVLLFSQSKQMLDIIEDCVKHTYSYMRMDGSTSISTRQPLIQQFNSDPSIFVFLLTTRVGGLGVNLTGANRVVIFDPDWNPSTDTQARERAWRIGQSRQVTIYRLITTGTIEEKIYHRQIFKQFLTNRVLKDPRQRRFFKSNDLFELFTLGSDSSKHGTETSAIFAGVGSDVKVRTSHSSPLRRKSIEKTSDGRTKEDVIRKRTSILRIEDGEKALEDSMEDVPGCSQSLLNRTLADPGPSKGNGDREPPGISEERRSNLKKSPLLKASSSPSSPRKNGILQAERKKKKKKDARLDGHRIAHLAKHAVYCPRSEKEEKPALSDAQQDDYVLTKLLKKSVHSALQHDNIMQSGHPDYLLVEGEADRVARDAVQALRESRRHCHRASSGVPTWTGSGNQGSSTPPPKKPRFGQKSNSNVACLLSSSKVQRDKDKQQGQAPATPNPKAGHFSGTELIKTAASKASTKAAALPPSESLLAQMRRRNSATASGPVSQDSVGSSTVAVDQPRQDLLADIRDFVAFQAETSSQASTAEILQKFKAKLPANDSALFKSMLKEICTFQRMNGEGIWKLKEDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJX2</accession>
    <name>A0A8B7XJX2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histamine N-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080437.1">
        <property type="nucleotide sequence ID" value="XM_022224745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJX2"/>
    <dbReference type="GeneID" id="110973719"/>
    <dbReference type="KEGG" id="aplc:110973719"/>
    <dbReference type="OMA" id="SGWASIW"/>
    <dbReference type="OrthoDB" id="5984880at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000118">
        <property type="entry name" value="Histamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080437.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33326" checksum="E0D87A41D4FCBCA0" modified="2022-01-19" version="1">MNANSLPSLLGNPDHYVKAFKVFCSRSAKFSVYSDWVDKVFSKAVVSKLQTSSDTQEELRVLGVGSGSGEMDCKMLEKLSKRFPRIDNRVVEPSQELVDKYQALVQSKAGDLQGVKCDWRHETIEQYEEAGNLTKFHVISAVHSMYYVDNFDSTLMYLYNCLVPGGVLATILLSENSGLSRFRTRFPCLQGRNHNTKTSTDICGSLDQQSIPHARHLHHQRVRVDITDCFDRASVEGGLLVDFITNVVDFRGAASDDLRRSVMEYLASSDCSERDNGAILMNTDWDSVVVYKPAESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLK3</accession>
    <name>A0A8B7XLK3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="7">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110974400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022081699.1">
        <property type="nucleotide sequence ID" value="XM_022226007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLK3"/>
    <dbReference type="GeneID" id="110974400"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="8">
        <location>
            <begin position="67"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022081699.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="43135" checksum="DBA97FE028AF3D4D" modified="2022-01-19" version="1">MFALLCRRFGAISRNSSRVLPAAVRYQYSTEQTEASFSVLDYKLHKLEFGPSANVTVTRDEALQLYRKMQVIRRLETAAGNLYKSKAIRGFCHLYSGQEACAVGIVAAMKKDDAVITAYRAHGWTYLMGVPVTGILTELTGRRTGCAKGKGGSMHMYTKNFYGGNGIVGAQVPLGAGIATALKYNGSESICVTLYGDGAANQGQIFEAYNIAKLWDLPCIFICENNKYGMGTAVERAAASTDYYTRGDYVPGIWVDGMDVLAVREATQFAADYCRSGKGPLVMEVETYRYSGHSMSDPGTSYRTRDEVQEIRQQRDPITNFKDRITTSGLATAQELKEIDVGVRAEIDAAVEHAKNDAELPVAETFTDIYSNTPPFMVRGCNPFSFHPLHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM72</accession>
    <name>A0A8B7XM72_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monoglyceride lipase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081070.1">
        <property type="nucleotide sequence ID" value="XM_022225378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM72"/>
    <dbReference type="GeneID" id="110974054"/>
    <dbReference type="KEGG" id="aplc:110974054"/>
    <dbReference type="CTD" id="11343"/>
    <dbReference type="OMA" id="SYEGWSH"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000117">
        <property type="entry name" value="Monoglyceride lipase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="40"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081070.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="33628" checksum="C128A2E55CBDB3FC" modified="2022-01-19" version="1">MAKCEKLSPQGTPYSSLAHFVNADGQYIYCKYWEPPTGTPVRALLCLVHGMGEHCERYNKLAQQFNNIGILVFTHDHIGHGKSEGSRVDIKHFQFFVRDCHQHIDLMKSKYEDLPVFLFGHSMGGTIAILVAYERPSLFTNTGVLLSAPAIKASPEIATPTKLFLGKILASIWPHAPMGQLESSSMSRDPEVVKDYETDPLIFHGKIKARFAVQTLQAMERLGNGLPDIRWPFLIQHGDQDKLAEISGSRLMYETAPSEDKTLTVYEGFYHELDKEPGGDGEKTIQELLDWVLQRLPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMY7</accession>
    <name>A0A8B7XMY7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110974702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082189.1">
        <property type="nucleotide sequence ID" value="XM_022226497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMY7"/>
    <dbReference type="GeneID" id="110974702"/>
    <dbReference type="KEGG" id="aplc:110974702"/>
    <dbReference type="OMA" id="GCDLWTV"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000003">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022082189.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31109" checksum="50F0F325D00E8E68" modified="2022-01-19" version="1">MKLLENPNLDAIGNALTIETGDCKISGRLESYSCKMAGNDKRLFKMLSQENGHTPDDLQALSPPQTQSQLSLSPRGGVSPQAVGLYGTGSGEETHGPLCHTCSRKMIFYLISTLNASFNPDYDFSDAKSHEFSREPSLDWTVNAVDSNMFSTAGEVYATQIRPKLWAAVNDEISPNECEIYSYNPDLESDPFGEEGVLWSFNYFFYNKKLKRILFFACRARSQTAAVGADSGIGRDFDMMLDEEISDDDDDVDDDVDEDNGMYVDDAYRYERVTPLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNE0</accession>
    <name>A0A8B7XNE0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Y+L amino acid transporter 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110974278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081505.1">
        <property type="nucleotide sequence ID" value="XM_022225813.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081506.1">
        <property type="nucleotide sequence ID" value="XM_022225814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNE0"/>
    <dbReference type="GeneID" id="110974278"/>
    <dbReference type="KEGG" id="aplc:110974278"/>
    <dbReference type="OMA" id="SESVILM"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022081505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081506.1"/>
        </source>
    </evidence>
    <sequence length="523" mass="57287" checksum="FD8015F185B8311C" modified="2022-01-19" version="1">MENKPANGSTGQMTAAEVADHAQDPDPRETGDSPTRLDEEDDGSKVKLQRQISLVSGVAINVGTIIGSGIFVSPKGVLLGVSSVGMTLVVWVLAGIISLLGALCFAELGTMLPSSGGFYFYLRAIYGEFVAFLYLWVSLIMQVPASCAVVAITFGRYAVQPFFPSADCGPPMAAIQLLALNSLLLCGFFNIFSVRLTTTVQNVFTVFKMLALTIIIVMGCVQLFKGETASFENSFEGTTYAGLGNALYSGLFSYAGWYNLNNVVEELRNPHKNLPRAIYITMSIVTVFYVFANVAYFTAMSPQELLASDAVAVTFGLKLLGVVAWCMPIFVAMSTFGSNNGSLLGLSRMFFVGARDRQLPNFLAMIDIKRKTPMPALLLVTFLTCVYVFGRDVYTLINYFNFVLWTSSGALSAGLIYLRWKQPERRRPYKVNIILPIFFTFASIALVVLGTISAPMDTLIGVAITLTGIPFYFIFVRPAKKMAVLHKLDVAITHWCQKLFLVTNEEKTNLTNGDINEEEKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XP92</accession>
    <name>A0A8B7XP92_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110974469 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110974469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081820.1">
        <property type="nucleotide sequence ID" value="XM_022226128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XP92"/>
    <dbReference type="GeneID" id="110974469"/>
    <dbReference type="KEGG" id="aplc:110974469"/>
    <dbReference type="OMA" id="ANHKCSF"/>
    <dbReference type="OrthoDB" id="5965452at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022081820.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30473" checksum="36520632F2E531FB" modified="2022-01-19" version="1">MGDPIRSYASIGRLNLQVADFREDLCPDEGPTVVRRKSSVRFLDEVTTINDNEACDPERALTRLRSETANHKCSFVAGEPYYSRGMDGGQTASERGSLDFTRWKLDRKEREARLEQNINWIREEITKLKQQDQSLMRQFLQLRSVIYKLKGTVTSDQRPAVKLPHIAASVDSFDRYESNAGGLEALQTGETNDLMLVYDEEGDLCELDDQMALMEDPYLPEFRGRTVSLLGPGNITRTRPGSGGFGYLKSRTMSFSVGTSARELDRAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRF3</accession>
    <name>A0A8B7XRF3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">GATA-binding factor 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC110975332</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022083423.1">
        <property type="nucleotide sequence ID" value="XM_022227731.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083424.1">
        <property type="nucleotide sequence ID" value="XM_022227732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRF3"/>
    <dbReference type="GeneID" id="110975332"/>
    <dbReference type="KEGG" id="aplc:110975332"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000001">
        <property type="entry name" value="GATA transcription factor (GATAd)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000032">
        <property type="entry name" value="Transcription factor GATA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF337">
        <property type="entry name" value="GATA-BINDING FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="358"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="446"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="493"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022083423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022083424.1"/>
        </source>
    </evidence>
    <sequence length="679" mass="72254" checksum="5406DFA7716DE939" modified="2022-01-19" version="1">MFMEQSDPAWPHPGALNRSPYADTQQRQLQRLAASERADSASETSGSESRGSSEEEADRSPGSSVSSRVDRRSVGSACTSHHTPSPPATAASSPPQHLVSPHLLSGGVASSNNAELYRGASACLAEPSQLLQSEDVEVFFNHLDRQPSPNSRQHQSHHQCLPSEGGLPEAPQQPSLNPHPHQDQFNPSMMYQSPMTNLPSVSAGGIQHSYDNSFLHSAGSPVYVPTTRPAVLSMPHAHSQYLQAAAPTGSPQQAMQGNTHPAAAAVWSQQSEAGYTATTTSHPSVGQRFAFPPSPPITSTGSPLTARHASTAHNGLGAYYVSPEIASWSAPFDSSVALHPNMITRRPSPENDMWTQDFGIGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMSRPLIKPQRRLDELGDLCDEKGPELGMESLEPSILRYKDRRWKPQSGSRREGIVCANCHTNTTTLWRRNKDGEPVCNACGLYYKLHGVNRPLAMKKDGIQTRKRKPKGSSKQQQQQVNGQQQSATPKSPKDPHNAQIGTALPPTSMHSPSIKMEPHFNYGMHPSLPGHMSLSGLANSPRLQTSHTPHHLDPAGTPVSGNNGSGGHAGRLLSNGSSAGHSPLNLVSPGGAGGSEHAASIQTTTNVVAQAAAHTLFAPGVNPSPPTAVAVSLDSGSITSAVSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRT5</accession>
    <name>A0A8B7XRT5_ACAPL</name>
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        <submittedName>
            <fullName evidence="7">Probable splicing factor, arginine/serine-rich 6 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110975408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083559.1">
        <property type="nucleotide sequence ID" value="XM_022227867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRT5"/>
    <dbReference type="GeneID" id="110975408"/>
    <dbReference type="KEGG" id="aplc:110975408"/>
    <dbReference type="OMA" id="RIRIRYS"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022083559.1"/>
        </source>
    </evidence>
    <sequence length="255" mass="30130" checksum="6B96E9969FA736F1" modified="2022-01-19" version="1">MSAQLFVGRLSKQTRQRDVEEVFRRYGPMLRCELKYGKHGTGMAYAFIDYEDRRDAEDALKFEDRQEICGQSIVVEWARGPKRGVSDDECYKCGGIGHFARNCRSESRGYRGGFGASYSRSRYRSRSRSRDRRRRSYRSRSRSPVRRRSRSRDRSRDRKRRSRSRDRRRSRSRSHHKRTPSRSRSRSHSPRKSRSRSPSRKRSASPRRSRSHRGSASPRRSRSRGSSRSRSRSRSRSPEQNGSRESRSASRSDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XS63</accession>
    <name>A0A8B7XS63_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[histone H4]-N-methyl-L-lysine(20) N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.362</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC110975028</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.362" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022082800.1">
        <property type="nucleotide sequence ID" value="XM_022227108.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082801.1">
        <property type="nucleotide sequence ID" value="XM_022227109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XS63"/>
    <dbReference type="GeneID" id="110975028"/>
    <dbReference type="KEGG" id="aplc:110975028"/>
    <dbReference type="OMA" id="MGPGWPL"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140941">
        <property type="term" value="F:histone H4K20me methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1700:FF:000001">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000006">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025790">
        <property type="entry name" value="Suv4-20_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51570">
        <property type="entry name" value="SAM_MT43_SUVAR420_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="121"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="574"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="658"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022082800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022082801.1"/>
        </source>
    </evidence>
    <sequence length="859" mass="96440" checksum="59D00CCEB4C0FF42" modified="2022-01-19" version="1">MMGIDGTGPGWPLKPSSGMNWKELGENDDLATSLVLDPYLNFTTHKMNTRFRPVDARKEYLRDIILRFKKSHNYERAYKGLVSGDWARVFFLNKSKHQVTIFKQHVFRYLAMFDKTSGFEVKPCFRYSLEGAGGKIVATRVWSKSDTILNLVGCIAELTECEENSLKTGVNDFSVMFSTRKNCAQLWLGPAAFINHDCRPNCKFVSTGRDTACVKVLRDIEPGEEITCFYGDGFFGEGNCHCECETCERRQMGAFTPKDMPVKIDENKYSLRDTDRRLRWQKAKNEEEGGPSQEEGSVVKSVLPSRLLRRSDSECSGSSDGSSCPWSRSRSSQPLSPSFLANQTLVDLIAEKKCLSKYDAQLLVAEGYKLREAKVVLTPHKIKEDGTLTVEEGGVRYASRLRREERRKAGREGRERRMSLNEEPVPSPRVEEAHLNGGIVDTEAVECVAASRTERRRSRESRKRRVSATEEMQELSKLPRETCLDPSGGVEGVSSVPGLRSRSGSVAAVGLALDQQSNCSSCDTEVTFNVRHLSKAPKAIEKDLTYESEISDCETKLKIRGVPRDRAIAGKRNLLDDGPARTNRHGGKRERRETDCSKNCKDLKVKHGKSEGLEVPPLILPKRKMTKYDAELIAEAVQKIPKLKIRMKDSNGCIEEVVTSSEDEVSPRQHSVSCESSSITTSQDQKLLLDVPDSPSRLTRGQRVLIPGPKLPQSPTSTSKTDSPPASPSLLRARANLKFNSPERKKTSHQFVPRMSQLRHLYEIPPHPILQKVDKSVPPKHINSSDVKTFYPSFPDSPKTEHLSDVLKSEESPSQTFQVSVKPVDNRNTRKIRLIFGQRTMDIQLPKTGKCYPTKSKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSH8</accession>
    <name>A0A8B7XSH8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Rho guanine nucleotide exchange factor 39-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110975548</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083812.1">
        <property type="nucleotide sequence ID" value="XM_022228120.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083813.1">
        <property type="nucleotide sequence ID" value="XM_022228121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSH8"/>
    <dbReference type="GeneID" id="110975548"/>
    <dbReference type="KEGG" id="aplc:110975548"/>
    <dbReference type="OMA" id="DLQVVFY"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051092">
        <property type="entry name" value="FYVE_RhoGEF_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673">
        <property type="entry name" value="FACIOGENITAL DYSPLASIA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12673:SF159">
        <property type="entry name" value="LD03170P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="64"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="269"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083813.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="60395" checksum="EF63E225D2E3E484" modified="2022-01-19" version="1">MEENQPLARASYRSVSSRKKKLNRSISWRERLSKGKETFKGDLEHLFRDKLHVPGNHAAKMARKRERVTCEIFTTERKYQNHLSIIVEHFLSPLESLGLIPADDHRIIFDNIAAIQAVNRELLAHMEEQGIAEAFIQLAPFMKVYCTYANNFEKASQKLQDWEHKRAAFVQFLREQEAKPECASLTLHALLITPIQRIPRYKLLLEELLSCTPENHEEYEKLQEAAARMTEVTYGINEYIREHENFQKMLLIQNSLTGGAPRIIAPGRTFIREGTLMKVSKKGSTAHERMFFLFNDMLIYAKPNLLDPLASTRSYCCRGVIPLDQCEVQCVLGELKTSGSGALFKIVHGENSLLLYSTNHNIALSWIDALQGAIQQLQHKQRSSRKAHHAMSGSKTPRHSIPLGKRVRHIGQRTSMRLKNMRNYPEAEDGKHDKDSLHPLRMELRRCKRPQGPGNTPIRTGRPRRLQRGPLQVRSNKQEESHDASVSIVDVTGYPDSPDVTDCQYTSGQLPDTASFNQDAAQQAFCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTT6</accession>
    <name>A0A8B7XTT6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110975443 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083642.1">
        <property type="nucleotide sequence ID" value="XM_022227950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTT6"/>
    <dbReference type="GeneID" id="110975443"/>
    <dbReference type="KEGG" id="aplc:110975443"/>
    <dbReference type="OMA" id="WIELINV"/>
    <dbReference type="OrthoDB" id="10533503at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="8"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083642.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41469" checksum="3A6490FCA7F8C734" modified="2022-01-19" version="1">MAAGNVEEKADVALFYHAHDEEEASTLKDALLGEGLTVKSYEDFQVGGYSPESRGSLIKNSWCVVLLLTEDFVNDTGMNEFETYTSLHHSIQKNLKKVFPVIHCDESSIPTALGCISGIYGSRPVDEQAAKISKGVKHLKPEPDVLQQGYQLIEPARKILKFTASELTKYFRMDDKIKAIHGELKKKVEENNPDDGKRHECWIECITDEMIKNDGGRPKGQRFTKNVTLKSATTELLHGLDGPTGHLCLVSLLLNKTPLKKHTDCAKLAEYLDPDNIFDLLKKCKVFPKWNPQELEAIEQLKSNRSKEAHQPVESSTDSEKELVESIKKTSISSYETLVVLPFKAEISKIVGEAGATANQSNVGEDQHDDAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUJ1</accession>
    <name>A0A8B7XUJ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110975938 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110975938</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084512.1">
        <property type="nucleotide sequence ID" value="XM_022228820.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084513.1">
        <property type="nucleotide sequence ID" value="XM_022228821.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084514.1">
        <property type="nucleotide sequence ID" value="XM_022228822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUJ1"/>
    <dbReference type="GeneID" id="110975938"/>
    <dbReference type="KEGG" id="aplc:110975938"/>
    <dbReference type="OrthoDB" id="5984509at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956:SF12">
        <property type="entry name" value="FLYWCH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20956">
        <property type="entry name" value="HEH2P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022084513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084514.1"/>
        </source>
    </evidence>
    <sequence length="738" mass="83471" checksum="2487A9B3961BB049" modified="2022-01-19" version="1">MQASSVDSSLLAALQDIQKFTGSGKDCSSKQADGGAYKGGRRFKITATQRKKHKLIDIHTGYTYTVRKTHKNSTLWQCSTRNKSIYCKATLIQMGNKFRMGNCSHIHPGQIGAAEFVGKKKSSKEKAHPKNTFVQDSPIEMEEICLTEDAAAMQEQNTMQEVPEITAGPVYLGSQVTVAQTDTDDMEEDANVGSVAKEQHLEDLDKNHNISSNSPERSQSGINAGANPMPYEVFLQENAEHVEVPLEGNLGPGVGCEVNHTETEGEEFQEERLPEAEYTVIDGSSQRRQAKLIDNAGYTYTLKNKTCFTSYWRCSIRNKNLLCRASVMQTKENFKRGKFNHIHPSKPNCEVAARLVAQVKAKVCQKPDNPTSSIVGEAMLETVGYYTPSPGLPKPNNLARTANRLRHKLSQGVDNIHTASIPVAFLQKVVNCKEKSHILLASPELLQLLSQMTRWYIDINRKVVKAPLKELMSVHSFITDDTGTRPIPLAFVLMSSQKKKDYKAVFSSIKERLPGKCSMEECVVPYEPALWRAISDIFPGVRCSGSSAHWSQAIRKKIKEFEIQRSDSYVREPRKVFRLLQKLVALAFLPAEFIPRMVNELHNKANTTTLHQLLNYLKATWIEGPTCMWSPTVWSVYLEPWRINNELEVWQLQLNSRMKKGKLPLSMLIMHLFNESKVVTTGSNLKPTSKRNLKRHHSMTYKNYQLIKFWKEFQRGDRTLKQLLKACVSLYQVENSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVB0</accession>
    <name>A0A8B7XVB0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBP80/20-dependent translation initiation factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084798.1">
        <property type="nucleotide sequence ID" value="XM_022229106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVB0"/>
    <dbReference type="GeneID" id="110976103"/>
    <dbReference type="KEGG" id="aplc:110976103"/>
    <dbReference type="OMA" id="EMATHEV"/>
    <dbReference type="OrthoDB" id="6357832at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF16">
        <property type="entry name" value="CBP80_20-DEPENDENT TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084798.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34179" checksum="F0C7D239F33E54AE" modified="2022-01-19" version="1">MASARSLNAGLVTSEVPNLRTNYLGRGRGRGSRGKNSNISSAPSGLAKEGDKQQNDNISPAEVEAAAEGVNYSALKAEDKVLYLLKKMCSQHPNQRIIELSAEDESAILEKVLESISTGQELCSLVSGLYDWTLQNPATTSCVASLSAQLSKFEKGGVSFRSALMNPLEADFQSRDEWNKDQPIRWLSYVCLMCDLYAMMKTAADGYLNALVEPVYSCLDQLLTDNKASDIQIGYATLKLKQLGKILQTKEPSKMELLMEGLRSRFLGSGTSATGRLLLLETIELYASGWQFDEETTTAYVELRQMSQEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVU8</accession>
    <name>A0A8B7XVU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Muscarinic acetylcholine receptor M3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110976217</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084993.1">
        <property type="nucleotide sequence ID" value="XM_022229301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVU8"/>
    <dbReference type="GeneID" id="110976217"/>
    <dbReference type="KEGG" id="aplc:110976217"/>
    <dbReference type="OMA" id="HAYHGRY"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016907">
        <property type="term" value="F:G protein-coupled acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000995">
        <property type="entry name" value="Musac_Ach_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00243">
        <property type="entry name" value="MUSCARINICR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="51"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022084993.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50372" checksum="4E1F437EC4DC14D5" modified="2022-01-19" version="1">MGFSTFQGTEYSIMDVTEAIETDSGGQTVLTTFQVTIAVLSGIFSFITVLGNLLVLFAFCVERRLRTYINYFIVALSFADLVAGAFTMPLYTVYWVLGFWPFGTALCDIYMYINHVFIHISLLGILVLAVDRYQAVYQPLKHLQKRTLRHASFMISIFYIIPFTLWLPWCLLWPYFAGARRIRDGFCYPQYVVDSLAFSILAPICFFWIPAPIISVLYWRIYVVIRRRSSQKRGPVMMQELETSSNSCKTKQQANTVPPSTNQDIADPELGHDNPGFEPNFQGESGDTSGNAPQIDSTGQNRASLAPDTPKLHTRKSQLPILDSIDQQVTHQSSKRQAEGKIPRAASSSIRRTGRESRNESNRATRTLTLIFVVLIVSSLPWSILVIVYALCPKCIPLVLYQSSVYIAHMNSTVNPFCYAIANPLYLQAISKLVCCGRRTTGRGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWP8</accession>
    <name>A0A8B7XWP8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="10">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110976044</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022084682.1">
        <property type="nucleotide sequence ID" value="XM_022228990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWP8"/>
    <dbReference type="GeneID" id="110976044"/>
    <dbReference type="KEGG" id="aplc:110976044"/>
    <dbReference type="CTD" id="89782"/>
    <dbReference type="OMA" id="MVRHHVH"/>
    <dbReference type="OrthoDB" id="527990at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00199">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.132.10:FF:000001">
        <property type="entry name" value="leishmanolysin-like peptidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.132.10">
        <property type="entry name" value="Leishmanolysin , domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.55.10">
        <property type="entry name" value="Leishmanolysin domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.34.10">
        <property type="entry name" value="Leishmanolysin domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942:SF0">
        <property type="entry name" value="LEISHMANOLYSIN-LIKE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 9 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034985980" description="Leishmanolysin-like peptidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="11">
        <location>
            <begin position="625"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601577-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022084682.1"/>
        </source>
    </evidence>
    <sequence length="705" mass="78321" checksum="416807073003603D" modified="2022-01-19" version="1">MGALVVFLSHLYIFGVVTANVCVNRPPARSEMKHRVHLEQAPGDRLRRRSTSHPLRIHVEYEDDVDALPVATSILVKNDLLPKAVYSISRMLNVKSTSTGPIRLNRACANSHYYTLANDTHEYCSGSCNDVTRCGPVTIPEKHLHACYTCDNTQSNCRKSSGETGPGVADTDFILYVTAENTVDCRIADTTAHASFCQLEASQDRPIAGYINLCPQALTSDPVQRTMQLTTVQHEIIHSLGFTAALYAFYRDSDGNPFTPRDPSGLPPFNESLGLYQWSNRVIKPIKRRDWVVRGGSISHTVNMMVTPNVAREARSHFGCSLLEGMELENNGGYGTKLTHFEKRLLENEAMTGTHTHERVFSRLTLAVLEDTGWYQPNYDMADPLDWGRGLGCDFVTKSCKYWMDTKRDAEESLSPFCDKIREEPFTLTCSVGRASVALCNLHRYDEHLAPQYQYFDSLPGVSSEDVGQYGGTSELADYCPFHQQFNYKETNGAKKSTTCGISSNTPSRSENVAAEYYGMRSACVEHADSWRQAQCDQYQEQQTWGAGCYQYSCSRDGLKITVEGVNHLCSWKGQQIQVSVTSSAYLHTGTIICPACQELCGAACPPEEVPGVTVELTVREPGDEGECPRLAYDTVGICVNDCDNCRSDEKCCSNGCGRTCQKVVVQKSTYEPCPSQAPETIRSKVMLLTSLMSLSFTCILPQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY85</accession>
    <name>A0A8B7XY85_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glomulin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085227.1">
        <property type="nucleotide sequence ID" value="XM_022229535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XY85"/>
    <dbReference type="GeneID" id="110976350"/>
    <dbReference type="KEGG" id="aplc:110976350"/>
    <dbReference type="OMA" id="TLCPMEH"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055105">
        <property type="term" value="F:ubiquitin-protein transferase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019516">
        <property type="entry name" value="Glomulin/ALF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15430">
        <property type="entry name" value="GLOMULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15430:SF1">
        <property type="entry name" value="GLOMULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022085227.1"/>
        </source>
    </evidence>
    <sequence length="672" mass="76300" checksum="E17B3ADA932EB18F" modified="2022-01-19" version="1">MAVNLRKSFQPFSGRSAQSLKSSHDEVYGLLSTIKGSVKAGSKQLRDVVSDGQYKGLVEYIAWDLLPILGPHLSHKEKNEEIYNDCVQIVLRLAELGNPKEMFIGILEQLDRFLDSLVHNDLLEPLQTVIRRLGLAKPLYYNQLLTSLYSHMERLSVPSVNGMGAMERRLIGQDADYSKMETTTLVLLEFLVPMVRDIEAALVTKQLSHTPKEIKEIEATRTEIMKFVLNILDHPLIAIEFKYQDDADEEAAEMEELGISEEARQRVIPRQEEFSLSKKAAEQCMLYLDLMGCSFSYLLLYASQHPVNLDTLSEKLKRNALKEQGEEVKDETLPVLGLSCFSYMVLVEGYQTNRMPSVYSAVYMMQIMMPYIEAMLRRTEEPILCKGLELLRSLVDRLDDLSLNSSVIDIKGNYLQVSECLVQIMVYCSSKLLRRMSVAIVVPYMNRFDWKGRHHMLRSLLSTTRHPGARGILIGQIKEYIHITLQCDEKNSWFIGRRFADLCSMVFRLDHGIRTDLLHSADKEIASLNFLRYLLLRDSGAEHLIGIWLWIEMIQEGYLNPLQTCLSMSLSHYRLKVDSTKKEIQEARLSNKHLTGKLTVAGKEYPPMPLDEQVKVLENSLYTIELIDCVLSRVNEIIAAGKNPQPAEGVTVRSSSSGGMDGAGVDSVTMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYG5</accession>
    <name>A0A8B7XYG5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">A disintegrin and metalloproteinase with thrombospondin motifs 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110976270</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085075.1">
        <property type="nucleotide sequence ID" value="XM_022229383.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976270"/>
    <dbReference type="KEGG" id="aplc:110976270"/>
    <dbReference type="OMA" id="THIWAKS"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF20">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034638723" evidence="16">
        <location>
            <begin position="30"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="18">
        <location>
            <begin position="260"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="17">
        <location>
            <begin position="1402"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022085075.1"/>
        </source>
    </evidence>
    <sequence length="1521" mass="164662" checksum="3B9105D7D3AF8330" modified="2022-01-19" version="1">MILHSKMERMMFISGMILFLVFQCTNVCGRSLDSQLMSSDDAKYYMDAFSSPETHEFEVVSPWEVEHSRRKREADNPFDISEFKFNAFGEEYHLQLTANRQLTRKGLKVEYVDANGNVEERPLPEDHKNCYKIGRVLSHEGASRVAISTCNNGLSGIVKLEGYELFIQKLSDNHTESVRRKRRDLDNPHIVYRRSADDEVVEDTEDADNGTDTHFCGLERGYYHYLETSMDVELPDEDGDEVRRRKRDVGCNNGVPVGSRTLELFVVIDAEMDRYHSIRGRNSTQITLTLFNMVASSYLHESLGVPVNIKIVRLQVLQNTSLDYGTGTLTVTAEGGDTLSSFCRYQRAMNSFDENSLNHFDTAVLISRYDLTLQGSRSLLGIAQFNGACSRDYACAYVEESGFGSGVVITHELGHNLGMEHDGDGRFSEVAASCQNGVNIMSSSRTYGPGSFIWSSCSKVQLENFVCHPFKTCLDDSSPSNTPIPLDPLDMPGVRYTADQQCQFINSGTTQSCPSTTCGHLTCRYSHGLCSGTGVAALDGTSCGTNKWCLEGNCVDIPSNNPPSTTPVNGGWSAWFEGPCSVTCGQGIRTRTRLCNNPVPQNGGLPCVGSETDTQSCSAQNCPTVVNGGWSSWQSGPCSVTCGGGQQTRTRTCTNPVPANGGTPCSGSDTQIISCNTQNCPNVVNGGWSSWQNQGSCSRTCGGGQQTQIRSCNNPLPQNGGAYCSGSNIQSVSCNTQDCLIVVNGGWSSWQTQGSCSKTCGGGQQTQTRSCNNPLPQNGGAYCQGSSFQIISCNVQPCPTVVHGGWSDWSYSLCSRSCGGGTQVRTRTCTNPIPQNGGSPCSGSNYQSGIQCNAQACAVDGGWTTWGEYSQCSASCGFGQRTRHRTCTNPAPGAGGAPCSGPNFETVQCGNGQGCPVDGGWSAWQPYGPCSVTCGTGQKMRTRTCTNPPPEHGGQTCTGSSTEYLQCSNAQACSVPVNGGWSAWQPVGGCSVTCGGGVQSRTRTCTNPIPQNGGLLCSGPSTDSQPCNTQSCPTSDQIVSGTFNEGTHGEYNEFLTIPVGSTSVVISNANVVTHMAIKDGNDFVLGEVVGNTLPPRRITELSYHGTVIVHDYFVTSVSAETITIAGPTTVELKVYVHVLLDPNVFGTQGVPDISWSFQSPSVEYQWTLTPGPCSVTCGTGVRTDVVRCVLISNQQQYVSHDESVCSHLPRPTPTVESCNEAPCQEARWYVGQLDCSGLCGQALGQRGVYCIALSSANFWQIVDESNCPAENKPSATAQCHGLPPCQTDNQEICNTVVTSQGSINRMISPTGGELCGYTIVAPAGMVVIMQFVDLDIACDQGEELVVKDSYTSKVDLCDVTISPGTSKVSSSNVVQIEHRTTQAGHGYNIIYSFTSYRQNSSCDEILLDSTGTIQSPGYPNNYPNNRLCKKYIIAPADMKIVISFNTLSLYGLCWRSSPLFYDYLTIHDYDKTTYRWFCGTWNDPSQHNYESESNRVRVTFRSDFFYSDQGFQATYSFVPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZ05</accession>
    <name>A0A8B7XZ05_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Testis-expressed protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086134.1">
        <property type="nucleotide sequence ID" value="XM_022230442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZ05"/>
    <dbReference type="GeneID" id="110976833"/>
    <dbReference type="KEGG" id="aplc:110976833"/>
    <dbReference type="OMA" id="FESFMVW"/>
    <dbReference type="OrthoDB" id="5984625at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043460">
        <property type="entry name" value="MEDAG/TEX26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33769:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33769">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 26 ISOFORM X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086134.1"/>
        </source>
    </evidence>
    <sequence length="396" mass="44779" checksum="8484BD9A6CCC62A1" modified="2022-01-19" version="1">MAATEIVTSQVREGWGTGETDHRAKSRSKQYLTEFGGDSLTAGFSKDLLQFYGKANAEDKRRCLELLTSLSIGEELTKHAAAKKPARPKGPKLQRPKTAMASLGRSGAPQVKRTMTTYRRDFPGVIAPPAPQARPKSTDGLYKASYELNGPVGTPTYNKEFYNKGYCRPQLIRSGTSSGDRRNNPHPFESFMVWRFPKHVPKDQQIYPGEITDQMMEEVLRDKCKSTYQNDYLGVPQGYQMQSAFENYVDWREKVPFSLASTMRFSYQFPKQQDLLRGNNSRYGCNKDKHLKASGIVPLSSTHQKHLRRHTTYDRFFNKPFRPGMVEVSKALDAGKLDEYLQLASEKERDVLQKMLESMAKCEQPRPPSASGSRPKSATSTRPANLSWISNWNGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2I1</accession>
    <name>A0A8B7Y2I1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Early growth response protein 1-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110977045</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EGR C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086510.1">
        <property type="nucleotide sequence ID" value="XM_022230818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2I1"/>
    <dbReference type="GeneID" id="110977045"/>
    <dbReference type="KEGG" id="aplc:110977045"/>
    <dbReference type="OMA" id="DVICTEP"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000092">
        <property type="entry name" value="Early growth response protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF60">
        <property type="entry name" value="STRIPE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="282"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="349"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="464"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022086510.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="55854" checksum="215B7DD02CEC466D" modified="2022-01-19" version="1">MSKKQQKSGEMRMDLDTLSQAALSQFDTSYINQSFFGSKSFPSAVSDEFARALPNPMAVPNTDLFIDCEQGDLPNFTGNMEDFEYKHTVTDPSFEHDHNMNTRSDTMPLCYHGTITTTAPQMSPDPDSPDGSPNPASWWATTDQGMLTPTVIGNIVSRSNTLINEAAPSGSQSTETQRLSREETYTPASSSSYDVICTEPLPMSSPDLATDTEQLPPYSCAYTQAAGLSSFDTLVDTLSSAACAAETSASQPVGTQFNEQSIKIDGVLKYTWPVSLESSSAFGRPVQQQQQHAVVSQQQQQPHSLKMSPSSSRSQASPQSVPCRTHTQQLGESMLLQISNPVDILNQPYASNLPTATTGKSPKPRKYISRPGKTPPHERPYACPADSCDRRFSRSDELTRHIRIHTGQKPFQCRICLRNFSRSDHLTTHIRTHTGEKPYSCETCGRKFARSDERKRHCKIHLRQKVKKESEQMKGASSCSYQLPHTSPSSSPSPSCSLPASTITTSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y300</accession>
    <name>A0A8B7Y300_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110977256</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110977256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM199 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086907.1">
        <property type="nucleotide sequence ID" value="XM_022231215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y300"/>
    <dbReference type="GeneID" id="110977256"/>
    <dbReference type="KEGG" id="aplc:110977256"/>
    <dbReference type="OMA" id="HEENCHS"/>
    <dbReference type="OrthoDB" id="6365484at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029672">
        <property type="entry name" value="FAM199X_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32003">
        <property type="entry name" value="PROTEIN FAM199X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32003:SF1">
        <property type="entry name" value="PROTEIN FAM199X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15814">
        <property type="entry name" value="FAM199X"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086907.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="35270" checksum="BB01D978DCD2469E" modified="2022-01-19" version="1">MLAEYNIPFQSPRSLGEEPVFLGTDDDLFQLDIDLIHVRTEDTITLNGLQGSIGEDLDEACLRLAAEHTLQETATTTLGKVEAVFGSPGSDYLAGAYLTALHDQDDIGKSEAHLASEFLQSDLDLACSIELSDSDDSLAHSTLSDIASPGPSSPTAKRKKLCPQWSEMDSEERARELDLIMHAIADRASIREQLELLRLIGQDTTVLPSDSRFQIDAAIIDDEKLESVREYLNQLAFHRSEADAESCEEQCHTQREPRYKKTQERRAQHRANRKRRNKEWKQGLKEKRSGLFDQEVVLSLQMQDDEEEIDILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y306</accession>
    <name>A0A8B7Y306_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110977605</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110977605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087563.1">
        <property type="nucleotide sequence ID" value="XM_022231871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y306"/>
    <dbReference type="GeneID" id="110977605"/>
    <dbReference type="KEGG" id="aplc:110977605"/>
    <dbReference type="OMA" id="SATIMTC"/>
    <dbReference type="OrthoDB" id="10160188at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034189394" evidence="2">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022087563.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="24980" checksum="C2E40A90337F2263" modified="2022-01-19" version="1">MRTATVYFLFVICAVFGWCAALDCYSCAASAGCGDPFDPTSATIMTCTAGNFCWTLWTRSGDIDVYTRGCIAPYACSTGCITTAQGIICSSCCDDQNLCNHKAIADGSSDVLQCFVCVYSSDPSLFGFGSDPACNDPVDPTGYGVLQQSCPNGECGVVKATVNGHTSITRLCIPTSAGGCTPACDALSTTCVTCCSTYLCNGGSDGGKPNTNAAPAPSMQPSGHIALLHLVLISVGLGMMGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4D3</accession>
    <name>A0A8B7Y4D3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase-like 2</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110977503</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022087407.1">
        <property type="nucleotide sequence ID" value="XM_022231715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4D3"/>
    <dbReference type="GeneID" id="110977503"/>
    <dbReference type="KEGG" id="aplc:110977503"/>
    <dbReference type="CTD" id="8999"/>
    <dbReference type="OMA" id="NINHYNA"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07846">
        <property type="entry name" value="STKc_CDKL2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000049">
        <property type="entry name" value="cyclin-dependent kinase-like 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000261">
        <property type="entry name" value="cyclin-dependent kinase-like 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF400">
        <property type="entry name" value="KINASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="10"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="318"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022087407.1"/>
        </source>
    </evidence>
    <sequence length="615" mass="68897" checksum="657C63577AD8B350" modified="2022-01-19" version="1">MRTLTAMEKYENLGLVGEGSYGMVMKCRHKETNQTVAIKKFIESEDDKMVKKIALREVRMLKQLRHENLVNLIEVFRRKKRLYLVFEFVDHTILDELERYPNGLDENVVRRCMWQVLKGIDFCHNHNIIHRDIKPENILVSKSGIVKLCDFGFARTIAGPGEIYTDYVATRWYRAPELLVGDTKYGKAVDIWALGCLQAEMCTGEPLFPGDSDIDQLYHIIKCFGNLIQRHKEVFMKNPLFVGMRLPEVRNVEPLEKRFPSLTALSITVMKSCLHLDPDERPTCSQLLRHDFFKKDGFDEKFPSELRAKIAKEFDCNPLLRPSGEEKEKEGGGEEKKRSKKSKKDQSHSHSDKEREREKYKKRHSDADRHKTPSTPPDIGDKHAKVSSEGSRKFSDVSESHKKTSSKTGSGSPIPPLTPTSKMLPSTMAASHNGASNPPMQSQGGAGTPAPMSTITVGTIGGSKGSHTSNSTSGPPPLRASDKVKKTTTNTYYKKPAQPPPAHHSSGMPTPVQSEKTTLHERTLPFDVLTASQRKSKGASSPRLEREVTHLPNLAGVEGDSSKKLDKKPKLKKSQHTPMPHIGHHNDPSHSGANSSHLNQTSSSDDFREHNLPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4S1</accession>
    <name>A0A8B7Y4S1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">cholesterol 7-desaturase</fullName>
            <ecNumber evidence="14">1.14.19.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110977953</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>cholesterol + NADH + O2 + H(+) = 7-dehydrocholesterol + NAD(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:51644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:51645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>cholesterol + NADPH + O2 + H(+) = 7-dehydrocholesterol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:45024"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17759"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:45025"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid hormone biosynthesis; dafachronic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cholesterol 7-desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.21" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022088194.1">
        <property type="nucleotide sequence ID" value="XM_022232502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4S1"/>
    <dbReference type="GeneID" id="110977953"/>
    <dbReference type="KEGG" id="aplc:110977953"/>
    <dbReference type="OMA" id="NEFYVNC"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA01020"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170056">
        <property type="term" value="F:cholesterol 7-desaturase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045605">
        <property type="entry name" value="KshA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19298">
        <property type="entry name" value="KshA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rieske" evidence="17">
        <location>
            <begin position="113"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022088194.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30452" checksum="C5D28470377A4A08" modified="2022-01-19" version="1">MGKTAILVYLVVPAALSVALFWSDAVAAHLPNDSRVLFLEFCVTHGLLAGLAYLTRAVYVFIYSPLVIYGDEGRDSYFIEKGQAGINREDAIAAMKRSRKIEDMPPVYPNGWFIACTSASLKKMETKYVHMLGLNLAVFRGESGRAYIIDAYCPHLGANLAVGGKVTGECIECPFHGWTYQGEDGKCVKIAYADKVPDFVKVPTYRSMEINNMILLWYHAEGEEPSWYPPELEKIKSGEMTLDGTFEFYVDCHIQDVAENSADEAHLQYLHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4U4</accession>
    <name>A0A8B7Y4U4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Rho GTPase-activating protein 7-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110977239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022086871.1">
        <property type="nucleotide sequence ID" value="XM_022231179.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086872.1">
        <property type="nucleotide sequence ID" value="XM_022231180.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977239"/>
    <dbReference type="KEGG" id="aplc:110977239"/>
    <dbReference type="OMA" id="CVNAMST"/>
    <dbReference type="OrthoDB" id="10003330at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035023">
        <property type="term" value="P:regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08869">
        <property type="entry name" value="START_RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000009">
        <property type="entry name" value="StAR related lipid transfer domain containing 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659:SF7">
        <property type="entry name" value="CROSSVEINLESS C, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659">
        <property type="entry name" value="RHO-TYPE GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="940"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="6">
        <location>
            <begin position="1180"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="616"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="742"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="748"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022086872.1"/>
        </source>
    </evidence>
    <sequence length="1393" mass="156186" checksum="721EBE867DC84FC5" modified="2022-01-19" version="1">MAESRDSVKDEGQTSPSSPSPRPLFRRMLAMVTPRTSHHHLGVSMDGMSDLSPDMRPRAASSPASAWSGHVPKIRVTRSGENSPTEGRSPRSSPLSSPDTERSKGWSMGAKPKKYKYLQCRLKSSREKAEIEAAETCQWLRAAGFPQYAQMFEECLFPIDISSVERDHDFLDQDLLDAVTRRLHILNKCSSMKIEAPLHRSGDESDEEDQCAISNKWKYTRSSGRWSRRMTDDGYPPLSPDTVGSNSAEGSPTLTHTPATRLDSSSRDSLVTTDNEGYTSASSFDSPAVIHKTYRTKRQSPNEITCSTSLGNHSLSPTRRTPPQSPTMLSIGEDGSRNAIIEISSPITVKKKTTEEEQGSKDRMKGAKNFLKRLDSLKLKRGSSQRGSKRGKEHKETLVISEPVIDDQGTLKRKIELFNCVDLDEACKIKSTPPHFMPLTPPMRRRAATGEKRNSEKRKGRVFSEPSSPLMSRKIDRHFYRELEEAHMTIITKKLTLSDVRNNNDEGERLFSLSPDKSLEIDISPASSPGTLERKLSCSGTVSCQCQSCQDKMAPWSSSEELSPKQAQTASPWTNSVYDNVPRTVHSSSEHVSTTQIAIAECEFLRQIYNLKNIGSEQSTADQPHSIPSTSTMASDQAHPSHHRSHSSVSRTQFETEKHDILTNITQLLLAEKNLDDDHLTVPIMRKRTRSNSLPDTRPCSMQVQNVTRFEGVDPELDGINTELEKLLNGINQSLHEMQENLRRDEGSLSSASSHSQVSSPVYSPVSSTFPSPFQSPLPSPHLNQSSSHKDLGDSILATSQDTTPPTTTMAMSVTSEGDMMIGPSDESLDMTNMPTTMRERRDSGVGNSLTRPSSSGKRPRIRWHSFQKSHRPSLNSRPFQISGLSVSQLLILRKLSLLKLTSLMERHSVTHRSGWSWMMPRFMKRIKSPDYKDRNIFGVPLLHILQTTGLPLPQSILYAMRFLRRTSAEAVGIFRKPGVRSRIQQLKRLNESNPDNMSYEGTTAYDVADMLKQYFRDLPEPVVTTKLSDTFISIFTSGMPKDLRLSALQAAIMLLPDENREVLQSLLLFLSDIAENSNENQMTAYNLAVCFAPSLFQLGKSPTPTIRQISSPRRTRKMATSRPDQKELIENVAANECLALMIREVKKLFMVPEDLMTKCHFSYMDLGEPVELEELGRKSSEEQGDYMSHMESCLQGLLKESRDKFKGWVVCPAVDGVDVAYKKVGDGHPLRLWKCSVEIGAPPADILQRVLRERHLWDEDLVKWRTVDALNKTTEVFQYVVNSMAPHPSRDYCVLRYWRNDLPRGTSALVSTSIEHPDGPLIGGVRGTVLASRFLIEPCGSGKSRLTHICRVDTKGRTVDWYNKAFGHIMARLVGKIRDLYIHEAEGPETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y860</accession>
    <name>A0A8B7Y860_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Gamma-aminobutyric acid type B receptor subunit 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110978236</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088747.1">
        <property type="nucleotide sequence ID" value="XM_022233055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y860"/>
    <dbReference type="GeneID" id="110978236"/>
    <dbReference type="KEGG" id="aplc:110978236"/>
    <dbReference type="OMA" id="IFRSEMA"/>
    <dbReference type="OrthoDB" id="16403at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF78">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034295339" evidence="11">
        <location>
            <begin position="20"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="405"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="679"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022088747.1"/>
        </source>
    </evidence>
    <sequence length="713" mass="79979" checksum="2C254F476554CEE4" modified="2022-01-19" version="1">MLLLFFLVTTASTPSVCQSNVTKLYLLGLYPESGPWAGAQTAIPATELAVKDINGNPDILPGYEILVIPRDSECNGGKATDEMYRELFNKSTTKVMVIGAGCSLATEPTAQASHYWNLIQTMAEFHRDAKDVGIQVIASESFVDDPTTHVEHLKESGARIIVGEFYTNMARKVYCQAYHQKMYGAKYVWIVPGWHTLNSLLVADDSIDCSLDQLKEVVSGQFGLAVLSFPTDPRRAPTVSGLTSRKFLERFKLLVDSEDPESLIGFLDMPFTYDTVWTAALALHEADQQLRNLDPPKTLADFTYDDTVTVQMLFDIISRMTFEGITGPVKFTSSGDRLGLIQIWQIQDNSRVDVGMMDSVANKHITWQGYEPVLWEGEAPPIDFIIELEDRQTIKTAVFITGVIFATVGIILACCFLAFNIHFRTLRVIKMSSPNINNLMLIGGMLAYSSVIFQGVDTSIASTETFVWMCKAKTWCLSIGFSLAFGSMFSKTWRVHKIFTNKTTTKMVVKDQRLFSWVASLVFLDVAVLVLWEIIDPLVALEKHRDKVTDEQNDDIVYAPIQVLCESRNQTYWIGAFYVIDGLLLIFGAFLAWETRTVSIPALNDSKNIGVCVYNVLILSFVGAPVSFVLEDRNANYALEACMIWLATTLTLSVIFVPKVRSRYDVQPAQSMLVSQIIRSQHCGHLTDAEREIQRLRRELDRMKMAVDRTTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9D7</accession>
    <name>A0A8B7Y9D7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110978457</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022089167.1">
        <property type="nucleotide sequence ID" value="XM_022233475.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089168.1">
        <property type="nucleotide sequence ID" value="XM_022233476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9D7"/>
    <dbReference type="GeneID" id="110978457"/>
    <dbReference type="KEGG" id="aplc:110978457"/>
    <dbReference type="OMA" id="DYVRGHS"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016206">
        <property type="term" value="F:catechol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042424">
        <property type="term" value="P:catecholamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000054">
        <property type="entry name" value="Catechol O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022089167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022089168.1"/>
        </source>
    </evidence>
    <sequence length="237" mass="26651" checksum="F8C6AE9B89B09337" modified="2022-01-19" version="1">MLRFMIYVSIPNAWRRLRYGNATEDRLLEFVKSTAVEGDAASVLSAVDRFKDEKEWMVSIERRKMEKIGTVLEETKPKNCLELGTYLGYSAVSTAVHLPEGARLITVEINEKYASIAKQLVDMAGLNQVSVVTGKSSDVIPELCSRYSMDKLDYLFIDHFGSQYLPDLERLEELHLLRKGTVIVADNVLFPGCPDYIKYVEGSNKFTTERFYCKVDGLGVQDAIAISVYNGGDHGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9H2</accession>
    <name>A0A8B7Y9H2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein kinase 40</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110978875</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022089888.1">
        <property type="nucleotide sequence ID" value="XM_022234196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9H2"/>
    <dbReference type="GeneID" id="110978875"/>
    <dbReference type="KEGG" id="aplc:110978875"/>
    <dbReference type="CTD" id="83931"/>
    <dbReference type="OMA" id="HGIFKDR"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13974">
        <property type="entry name" value="STKc_SHIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024236">
        <property type="entry name" value="Ser/Thr_kinase_40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF16">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="216"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022089888.1"/>
        </source>
    </evidence>
    <sequence length="618" mass="68780" checksum="AA517D8B9E569DC8" modified="2022-01-19" version="1">MKRKVPSLNELHERQHSHGNRSRRPVQRDSSETNVSPSEVSRRRDRDLPVLVTSFSSSSESSDSGFSDLSPSTFILERPGYSQEQPSVSNTSGFASVPSVSPVTSAVPQYLNSSTTSSSHSPLTAQLGAAISRSLSQPSQEALLSQSLLTPIQDPTSASLITTPSLSSLQQTAQTVASTLLQPSELSGSIGTTTTAPSTQRVNRSHPLTLKRAGPYLLGPRLGTSPVRSIVHCLARKEGTDNFYSMKLLTLSEQGKESNDERQGKMLLHTEYSLLSLLHNQEGVVHHHGLFQDRAYELKQDHPRSSKGQRPAPTGRYKKRLCLVLDCLAAHEFSNKTSDLMNLQHYVIQEKKLSEKEAIIMFSDVVRIVESLHKKNIVHRDLKLGNMVLNKRTRRITITNFCLGKHLVSDRDLLKDQRGSPAYISPDVLSGKPYLGKPSDMWALGVVLFTMLYGQFPFYDSVPQELFRKIKAAEYLIPNDGRVSENTINLIRNLLVLDPAVRMTATQVAEVLDTTLAMWKSLALQGEQLQVVPDLDIDGDGGEDVDGSPPAKRMKETSLQTPPDWEFKLHTERSVISLDMRLQPPTRRRLMRPPVHKLSQDARPLTQAEKMAHRNLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBF4</accession>
    <name>A0A8B7YBF4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly 2 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">HESB-like domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110979246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterotetramer; forms a dimer of dimers with IBA57. Interacts with [2Fe-2S]-ISCA2 forming the heterodimer [2Fe- 2S]-ISCA2-IBA57 complex; [2Fe-2S] cluster binding is absolutely required to promote the complex formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090558.1">
        <property type="nucleotide sequence ID" value="XM_022234866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBF4"/>
    <dbReference type="GeneID" id="110979246"/>
    <dbReference type="KEGG" id="aplc:110979246"/>
    <dbReference type="CTD" id="122961"/>
    <dbReference type="OMA" id="SFQIHNP"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120510">
        <property type="term" value="C:mitochondrial [4Fe-4S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000006">
        <property type="entry name" value="Iron-sulfur cluster assembly 2 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="10">
        <location>
            <begin position="47"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022090558.1"/>
        </source>
    </evidence>
    <sequence length="153" mass="16949" checksum="4ADCED07F6D9DC83" modified="2022-01-19" version="1">MAAYMMKRCWSLGRALRGQLHHQVCQKGSYPKHFSVSTEAVATEDSINITDSCVKQLSRINDGDKHLRVLVEGGGCSGFQCKFQLDSQENVTGEDRVFERDGVKVIVDEVSLGYIKGATVDYHEELIRSAFRVINIPMAENGCSCGVSFSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCI1</accession>
    <name>A0A8B7YCI1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110978980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022090085.1">
        <property type="nucleotide sequence ID" value="XM_022234393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCI1"/>
    <dbReference type="GeneID" id="110978980"/>
    <dbReference type="KEGG" id="aplc:110978980"/>
    <dbReference type="OMA" id="CTHETEQ"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="11">
        <location>
            <begin position="53"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022090085.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30225" checksum="3DEA1F7FC72E59F1" modified="2022-01-19" version="1">MDSANRTQFKSAHLGTAISLYDRQSISDTAKGIIKANPSAKRDCDDPFYICDLGDVIAKDRKWRELLPTVETFYAVKCNSDPIILRLLIGLGRGLDCASKREIQMVLDAGASPDRIIYAHPCKQGSHLRYAKENGVKLMTFDSADELRKICNVFTEAKLVLRMKYDDPSAVINLGSKFGCPLDGIPRLMEAAKTLGMDVVGISFHVGTGSKDPKVFAGAISYAKTLFRVGKAIGYDMTLLDIGGGFPGKTSFRVGFQQFAEVISESLKEHFRQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDN1</accession>
    <name>A0A8B7YDN1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase TRIM71-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091364.1">
        <property type="nucleotide sequence ID" value="XM_022235672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDN1"/>
    <dbReference type="GeneID" id="110979663"/>
    <dbReference type="KEGG" id="aplc:110979663"/>
    <dbReference type="OMA" id="EMAAHID"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF303">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="176"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="220"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091364.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43102" checksum="756F441A20FBAD26" modified="2022-01-19" version="1">MAASSLLEKIGDFLECQICLETFKHPKVLQCLHTFCQNCLDQMAPNGTNTVVCPTCRGETVLPGEGVVDLKNNFVLANLLELVTSLQKPLVGEITTDGNSNTSFLCSNCDDDNAAHATSRCLNCCEFLCAECVAAHRRLKALRHHVMRDIRAWLAAGQQVGTSRDTGTEPNGHQAGTVYTCAEHTDAEVTTYCEACDLLICDTCSRTEHVRTPHRLVTLHEAAERQREEIKTILADCKRKLGVFSTAIECTVQIARDLQRRTDRAQKDLQNTSREYMRLIQEEQTRLINELHKKKEDKESEMAAHIDSLQRAVDMIRNMCSLADNSLINGSHVDILRAKTQLVNHRQQLDRVSIRNMPIDTSSLRFVPSTEPNVMQNKLGRIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFJ8</accession>
    <name>A0A8B7YFJ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycogen-binding subunit 76A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092009.1">
        <property type="nucleotide sequence ID" value="XM_022236317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFJ8"/>
    <dbReference type="GeneID" id="110980036"/>
    <dbReference type="KEGG" id="aplc:110980036"/>
    <dbReference type="OMA" id="HAMGHGQ"/>
    <dbReference type="OrthoDB" id="8942186at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF53">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="236"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022092009.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="39104" checksum="67D1B626C92B856E" modified="2022-01-19" version="1">MLARSAGSPDRVRCEEFTHINGFPFAPRKMTAKTLTNGDTVWNGTTTVSEMETTSVKSGRMKNVSRPPPIDIAIARSASSREDDDCDCDSGSSEDRCCEVPCEKTSQGEPGSPQFVSSEDSITSPTVTSPASVASSTDTTDGGILRRKSSIKDVTKTPETPGGKSVRFADALGLDLETVRDILESESPPDYPSMAAAACAVAVGLDGASGSPALQAIQPRYLSMSFVQPGGQPDFVTRVNQQSVCLENAVLSDFTVLGTIKVQNLSYHKIVKVRYSADGWNSFGDIPASYVQNSCDGPTDRFSFGLTAPRDMAVGDRLEFCICYTAGNQDYWDNNFGKNYALVCHSQGDIIDSENTFLWTHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YG99</accession>
    <name>A0A8B7YG99_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17 18 19 20" type="primary">LOC110979301</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090666.1">
        <property type="nucleotide sequence ID" value="XM_022234974.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090667.1">
        <property type="nucleotide sequence ID" value="XM_022234975.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090668.1">
        <property type="nucleotide sequence ID" value="XM_022234976.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090669.1">
        <property type="nucleotide sequence ID" value="XM_022234977.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090671.1">
        <property type="nucleotide sequence ID" value="XM_022234979.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090672.1">
        <property type="nucleotide sequence ID" value="XM_022234980.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090673.1">
        <property type="nucleotide sequence ID" value="XM_022234981.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090674.1">
        <property type="nucleotide sequence ID" value="XM_022234982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YG99"/>
    <dbReference type="GeneID" id="110979301"/>
    <dbReference type="KEGG" id="aplc:110979301"/>
    <dbReference type="CTD" id="5888"/>
    <dbReference type="OMA" id="RAYNSNH"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="96"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="274"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022090666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022090667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022090668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022090669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022090671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022090672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022090673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022090674.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="36776" checksum="25CC382D59B2D552" modified="2022-01-19" version="1">MQQQQQNAGQEEDCQEDFGPLMIGRLESQGISANDVKKLEEAGLHTVESVAYATKKELCNIKGISEAKADKILNEAMKLVPMGFTTATQFHQQRAEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQLCHTLAVTCQLPIDSGGGEGKCLYIDTEGTFRPERLIAVAERYNLSSSDVLDNVAYARAYNSDHQSQLLIQASAMMAQSRYALLIVDSATALYRTDYSGRGELASRQMHLAKFLRCLLRIADEYGVAVVITNQVVAQVDGSAMFAADPKKPIGGNIMAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIC1</accession>
    <name>A0A8B7YIC1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110980520</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110980520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092973.1">
        <property type="nucleotide sequence ID" value="XM_022237281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIC1"/>
    <dbReference type="GeneID" id="110980520"/>
    <dbReference type="KEGG" id="aplc:110980520"/>
    <dbReference type="OrthoDB" id="5989442at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022092973.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14773" checksum="D993A88DEF82E744" modified="2022-01-19" version="1">MASDDSQSIYRKVDTILKNQKVQLSLLRTLNSKASGPDEEDVDDLLPRLMDLVEEIDSLSQELDNSEDPNFRRKLIHHLNTLGGFDLGETAGACQKSHPAAKRIKIEETLTNVLKYCPHEKKGGGTNTRNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIK4</accession>
    <name>A0A8B7YIK4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">maleylacetoacetate isomerase</fullName>
            <ecNumber evidence="5">5.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110980561</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-maleylacetoacetate = 4-fumarylacetoacetate</text>
            <dbReference type="Rhea" id="RHEA:14817"/>
            <dbReference type="ChEBI" id="CHEBI:17105"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="EC" id="5.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.2" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022093063.1">
        <property type="nucleotide sequence ID" value="XM_022237371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIK4"/>
    <dbReference type="GeneID" id="110980561"/>
    <dbReference type="KEGG" id="aplc:110980561"/>
    <dbReference type="CTD" id="2954"/>
    <dbReference type="OMA" id="VYNAHRF"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00340"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03042">
        <property type="entry name" value="GST_N_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034333">
        <property type="entry name" value="GST_Zeta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="89"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022093063.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23828" checksum="3FA739F39C71FAD0" modified="2022-01-19" version="1">MAGKPVLYSYFRSSCSWRVRIALAVKGIEYEYAAVNLLKSEHKGEKYLSLNPNGQVPAMHIDGMVLTQSNAIIEYLDETREGPSLLPKDPKKRFAARQLSQIISCGIQPLQNLSVLRYIGEERKVEWAQKVISDGFETFEKIVEQTAGKYCVGDDITMADLCLVPQVFNANRFKVNMSNYPIISRINAALLELDAFSVAHPSKQPDCPDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YL60</accession>
    <name>A0A8B7YL60_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110981078</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093994.1">
        <property type="nucleotide sequence ID" value="XM_022238302.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981078"/>
    <dbReference type="KEGG" id="aplc:110981078"/>
    <dbReference type="OMA" id="TRRPCAT"/>
    <dbReference type="OrthoDB" id="8863506at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093994.1"/>
        </source>
    </evidence>
    <sequence length="406" mass="42579" checksum="900C447B17C5CF77" modified="2022-01-19" version="1">MYHPSQTPYLKLSRERVAAGVAMYHPQSNSLPKAVAGAGGGRRPASPSELAVGRRPKRPQLGGCAARTVHEARPTPVQARPAPQRLRSRRVGLKGSPARCRGPRAPHAATRRPCATAGRAPMTGQAAEGTEGARTRTVPQSEGGSAAARTRRALPLYRIQVGRASNNRPRTRGTSARPTPARPGTGRPSQAAAARRRRHAGGCSQSSLLRPGGRCDHGRFLGSSXAAEGTEGGPRADGPAVRRGGAPPPGHGAPGRPPPARRPLARPAPGRRDPLPAPARPTQPSEPILLPKLRIRLADFPYLHCSIDQRLFTLETGCGYGYDPRRRSTHSPAFSRAGRSSPDAAGDAALYGAAAPSSGQADSRDPAPYQEKKTLPGAPAGVCGLACFAARTAAEDGGLRLRVREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLE5</accession>
    <name>A0A8B7YLE5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Regulator of nonsense transcripts 3B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110980793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093457.1">
        <property type="nucleotide sequence ID" value="XM_022237765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLE5"/>
    <dbReference type="GeneID" id="110980793"/>
    <dbReference type="KEGG" id="aplc:110980793"/>
    <dbReference type="OMA" id="YFVGPDW"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000717">
        <property type="entry name" value="regulator of nonsense transcripts 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022093457.1"/>
        </source>
    </evidence>
    <sequence length="749" mass="85749" checksum="00D60EF25C4B18A9" modified="2022-01-19" version="1">MTKEVKNEKSSGKEDASEKRKVKEAPSTKVVIRCLPPTLTEADFLEQISPLPNNNYLYYVKADRSLEVNAFCRAYINFINPEDIVPFRDQWDGYSFTDAKGTEYPAVVEFAPYQKIPKKQGRKVDPRCGTIENDDDFKVFAESLQAEVERLPSAETYLEELEAKLSEKEAKELTPLLAFLKNKKLERVKIRQEARDERRRKEREQKKREEERRRQREKQQRQREREAKEKARDKKEGEKEEPQKIKLLKKPEEEKKDRKEDAAAMDAKGKEKMGRRDQARRDDSRKERDTKPQAKPDREDRERPPRHKDRDPERERRDREREHQRTREKERNKDRGGERQPDRDRDRHHGGDRGGGERDRGRDKDVGAAPEKRSPKDSDSSSKGQAPRDDKRRDSHSDRQVRGGGRDSERAKRNEPPSRGSDQRRSEKSDVARQSKSAALNGEGSSGRKDEKEIASADKRPACGRRSSDLGTDSSEGSSEKSGKSTRGKEGTDRLRNKDRPAMALYKPGQRLSSSKSHEDKELGDKAKGQRSSPRDGDAKPVSQPDQVKTGSERRDGRRESKDSGGGQDEGAFPGKGGGKGQGRHDHRREDRNRRDGHGSRGGEQRPPRREGGKEDRPKRDDRPRERDRGTGQTRDGDKVQSSESSKSDSSDKLRDKGSATHREGDKSQDKPRDRGGDKRGGTPRDGDRHRDRGGDRGRDRGSDATKDRKGDRPRDRGSDKPKDKRVDKPREKEGQKPAEKGNEKQPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQ17</accession>
    <name>A0A8B7YQ17_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110981344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094545.1">
        <property type="nucleotide sequence ID" value="XM_022238853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQ17"/>
    <dbReference type="GeneID" id="110981344"/>
    <dbReference type="KEGG" id="aplc:110981344"/>
    <dbReference type="CTD" id="23016"/>
    <dbReference type="OMA" id="YNTRIPK"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11367">
        <property type="entry name" value="RNase_PH_RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="45"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="208"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022094545.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="32020" checksum="DA9FC8A31DB791EB" modified="2022-01-19" version="1">MHVLSCELLADGRMAKVRLSAGEKTFIIHGVQDGLRTDGRSCDAFRPMELECGVVSNTSGSARLRLSNTDILVGVKAEMGKPRPTRPGEGYVEFFIDLSANASPEFEGRGGEELATEIANTLSSTYDLTSVLDYTSLCVLPEQCCWVLYVDVVVLECGGNLFDAIGIAVKAALYNTRIPKVKVQDGEGQEEIEVSDDPHDVVLLDTSNMPVLVTVSKVGQQHVVDATLEEEACCLACIVMAVNPKGALVGMEKKGASSLTLNSIQDMITTGKKVGMNLNSNLSSVLQEIGQNTSSTGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQN6</accession>
    <name>A0A8B7YQN6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Multidrug resistance-associated protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110980956</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093741.1">
        <property type="nucleotide sequence ID" value="XM_022238049.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980956"/>
    <dbReference type="KEGG" id="aplc:110980956"/>
    <dbReference type="OMA" id="IRCIRVI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18592">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18599">
        <property type="entry name" value="ABC_6TM_MRP5_8_9_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000012">
        <property type="entry name" value="ATP binding cassette subfamily C member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000015">
        <property type="entry name" value="multidrug resistance-associated protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002835">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF447">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="948"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1139"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="167"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="587"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="891"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1230"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="489"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="811"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="576"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022093741.1"/>
        </source>
    </evidence>
    <sequence length="1476" mass="163421" checksum="C9A7E8EAC7792F4D" modified="2022-01-19" version="1">MGEDTPDDIESTGSDQPRAGNAVDLIGAFPVDNAALADIRTDEDVVLKPEDERQITYRKRKGVTKYKETMKVLVPVRPKPKSSAFLPLDHSGLFSYLTLSWLTPMFKKAAKRQLEVSDFWAFSDRDSGHLNGDRFQLMWDEELKKKGKDKASLSAVALRYVRTRHVLAVLSLLLAFSCLFVITAILVQRLLMYTEAEEQDLGYGLGIVFAILGLNILRVIFDVAYWMTSLRSANRLRNGLLSMMFKKVARLRSLQDKTVGEIVNICTNDSQRLFDAMVIGNLLIASCFLLVSCITAVSIIIGPAALIGVLGTFMVITPLQLVMGRVIAKFRQRGIRITDERVQKMSEVLTFVKLIKMYAWEAPFAKKVAAIRARERTVLERVAYIISFSLSLVPLVPNAASVLTIIIHISLGNDITAAEAFTLIAVLNSMRVVLGPTPFAMRVLAESAIALRRIRSVLDMSDIPPLQHMPPNDQYSVVISGGTFAWDKIRSTDSGKGEDRDEDEEKHAADGATINGVTVAVDDTKPGNGIENGGPSVLSDSPTEEGSENFEDVPLNEAGNTNNNASSSTSNGKKGGRIEKARKGSEVSGDEPTNPDDLKAKTLFDIDLSLEKGQLTGVCGAVGSGKSSLISAILGQMHTMEGSLAVSGSFAYASQEPWIFNASLQENILFGAEMEENRYQTAIKACCLKQDLEILTDGDLTEIGERGINLSGGQKQRVSLARAVYANRDVYLLDDPLSAVDAHVGLHIFNECIKGALQGKTVLFVTHQLQYLKDCDTILTMVDGRIAERGTHEELMNNEGEYARLIRKHHAKAESEENGNEDVELHREEGDKLQRSVSRMSARSVASDASEELGKQEGGKLVQEEDRSAKAVGWVTYKGYMKAAGGYHMILLAFLTYILVIGSLNFNNWWLSFWLNQGNGTQIEVNGTNPGDPPTLVTIGNIADHPDLYFYMLIYGVTLVATLVFGGLKSGVLMKVLLKASSTMHDIVFVKVFRSPMSFFDTTPTGRILNRFSKDMDEVDVQLPTNLELFTQNMFLILFALITICIVFPYFLAVMVPIVFFFGVILYYYRRGTRAIKRIENITRSPWFSHIMATVQGLSTIHAYGKTEEFIDRFVNLLDNNAQPYMIFRMASRWAGQRLEVLIITASLVTNLFVVLTYGIVSPALAGLAVSYTIQITGLFQITILMASETEARLTSVERILNYTRILTSEAPAHIEETAPEEDWPQHGEIEFKNYKMRYRDNLPLVIKGINCHIKPKEKIGIVGRTGSGKSSLGVALFRLVEPSSGEILIDKVSIATIGLNDLRSKLSIIPQDPVLFKGTVRYNLDPFEDYSDGKVWEALERTYMKEKISALDNQLEAPVVEGGDNFSVGERQLLCMARALLRNSKILMLDEATAAIDTDTDSLIQTTIREAFSECTMLTIAHRLNTILDSDRVLVMDDGEIAEFDKPASLLANPNSKFFKMMEAAESQKHSLSAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSE8</accession>
    <name>A0A8B7YSE8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase TRIM71-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982235</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096209.1">
        <property type="nucleotide sequence ID" value="XM_022240517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSE8"/>
    <dbReference type="GeneID" id="110982235"/>
    <dbReference type="KEGG" id="aplc:110982235"/>
    <dbReference type="OMA" id="DECNQIA"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF291">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022096209.1"/>
        </source>
    </evidence>
    <sequence length="739" mass="82821" checksum="265392E557651C57" modified="2022-01-19" version="1">MATKESTGHHLECSKCLNRFQDPKLLSCLHSFCLACLQELQQHADLSQKNALCPICRKEITTQNVVDLPSNLTLSALVEEVAVQEQLREGQGSGVKCQACVEQNQAVSRCADCDHFLCQDCQRAHQRLTIMKSHTIHTVAQLKSGEVVYRSKLRDFVPKCGKHTDQSLSIYCSTCQRLTCTTCSILHHKGTEHSLSDLSEAFDKCKQEVMQQIAAVEAIKVGFSEAASETGESLQTLQATFDETNQKITDEANKEVAKIRDKEQRKKQELKQIYQERVKIFEAAETANKEKVAKLDRKIDSTNQMIAQASCYEVLGIKQTLLQNLKELQRTITEPVKLSQELKAVEFEKGVKPLGRMAAEAEHHLESKAAQFTPPKAPNRSHVQQCPNTEIKDTVEVLLEEPGSASLKDVGRKGQVGKNQLAEKPDTEQKSSKCSDQWSFGILVPRDQPKSESKLTVEESHQPEGSQQEEHWILAGKIERLGSDQIKFRSPYDVAVFSNNELVIADTEHKKLIQSSLTANPWSDVSSILEINGLTDPLHVSVNKDDQLIVLDSHTCTVNIFNMNYKLLRQFIPGKWTNGEPTCLSVDECNQIAVGFRNQKMVFLHSSDGSLIRSLHATMIDSYLATFKQRFIYTNYWNKMLYSQDYNGDIVFSVNIPSNSPSYWGPNGVCCDKRGNIYVAVRGFASSYEIQRFSPDGANLGSVITQRSMPRGISLASDDHCLVVATKCSVSIYRRVTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSN1</accession>
    <name>A0A8B7YSN1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sphingosine-1-phosphate phosphatase 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110982288</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096298.1">
        <property type="nucleotide sequence ID" value="XM_022240606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSN1"/>
    <dbReference type="GeneID" id="110982288"/>
    <dbReference type="KEGG" id="aplc:110982288"/>
    <dbReference type="OMA" id="HYEYSHT"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006670">
        <property type="term" value="P:sphingosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="171"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022096298.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="50045" checksum="EEE3BF54CC8136D9" modified="2022-01-19" version="1">MYAHGRPVRPMNNLLLATRTYTTHRQVEEKPPKRANMKMTWPKIFGSSSESNSLPLYDACTVARLQRFFGLYPAPSPVVSKNGRSSLTNGTSNGPSASASQDKPAENGTVGPAGSEHGSSLKNGSRVKPKYYVAHNKWWFYLFSMGATLGDDVFYFMIFPMAAANLSWWATRRMVIIWGICMYIGQASKELLKWPRPSEPPVVRLERRYFMEYGMPSTHAMVGTLMPFTYLAATWNHYEYSHTLGALLACSWTLLVCFSRLYKGMHFVLDLVVGVTLTAILMLFIWPWLDVIDHFILTHPQAPLVIISSAVFLCICYPSQNGVAATRADTITILGSVSGILCGFWFLHRSGMVPDVAEPLGGAIAWPGWGAAGIMLLKYAFSQVLAVVVYLFTRAVLLQAIAVIFNTEINENTKKLLFVELPYRYITFLVLLFNLYVVSPLVFAKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTS1</accession>
    <name>A0A8B7YTS1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bifunctional lysine-specific demethylase and histidyl-hydroxylase</fullName>
            <ecNumber evidence="12">1.14.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110982530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROX family. NO66 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022096693.1">
        <property type="nucleotide sequence ID" value="XM_022241001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTS1"/>
    <dbReference type="GeneID" id="110982530"/>
    <dbReference type="KEGG" id="aplc:110982530"/>
    <dbReference type="CTD" id="79697"/>
    <dbReference type="OMA" id="YLEYMGV"/>
    <dbReference type="OrthoDB" id="425950at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032453">
        <property type="term" value="F:histone H3K4 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000013">
        <property type="entry name" value="Ribosomal oxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1500:FF:000001">
        <property type="entry name" value="ribosomal oxygenase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.40:FF:000001">
        <property type="entry name" value="ribosomal oxygenase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1500">
        <property type="entry name" value="JmjC domain-containing ribosomal oxygenase (ROX), dimer domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039994">
        <property type="entry name" value="NO66-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049043">
        <property type="entry name" value="WHD_RIOX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096">
        <property type="entry name" value="MINA53 MYC INDUCED NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13096:SF8">
        <property type="entry name" value="RIBOSOMAL OXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08007">
        <property type="entry name" value="JmjC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21233">
        <property type="entry name" value="WHD_RIOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="14">
        <location>
            <begin position="255"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022096693.1"/>
        </source>
    </evidence>
    <sequence length="603" mass="67635" checksum="163C9EE9CA424FE6" modified="2022-01-19" version="1">MKTPQSTKKISAFAALGSKIKAAGGETRTGKVAKKYTVTEKQKKIPCSKKFRQSLRVRKSNQTDSTSNHEQSTNGHVKRSSISAEHDLKGVVPGTSHNVRKKRSSNSLTCQDSVTTAPPPKRKYVSKKPPVKTDICYQEEPGTSLTALLQELPAAGTDSAAEAEKLFRWLISPVTPDDFFNGLWEKKPLLLKRHMPDYNADLFSCEELHNILRENDLQFTTNIDVTTYSEGKRQTHNPVGRAHAPVVWDFYKNGCSVRLLNPQTYSDAIWKLNSLLQEYFGSFVGANIYLTPAGSQGFAPHYDDIEAFVLQLEGKKYWRLYSPKNSQEVLPRFSSANFTQEEIGEPIFDTVLEPGDLLYFPRGTIHQASTPEDSHSLHITLSTCQCNTWGDLLEKLLPQTLQTAMSAEAELRQSLPRGYMQYTGIANSESTDPRRITFLSKVSEMMIKLAQYAVIDDAADQMARGVIHDSLPPKLSQDEHVCSIFGSGPVCKNGKVSNEVEIREDTQIRIVRRGVVRLIAEDDQVRVYHTLENSRVYHSKQPQFVEIPAEAASAVEYLLHTYPAFTDVSSLPLVDEWQDKQVELAQVLYERGIVVSKKPLQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUK6</accession>
    <name>A0A8B7YUK6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">FAS-associated death domain protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110982684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096973.1">
        <property type="nucleotide sequence ID" value="XM_022241281.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096974.1">
        <property type="nucleotide sequence ID" value="XM_022241282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUK6"/>
    <dbReference type="GeneID" id="110982684"/>
    <dbReference type="KEGG" id="aplc:110982684"/>
    <dbReference type="OrthoDB" id="100767at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169:SF7">
        <property type="entry name" value="CASPASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48169">
        <property type="entry name" value="DED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01335">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00031">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="2">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022096974.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="23068" checksum="16352CFD850C76D8" modified="2022-01-19" version="1">MPGYRKTLSNIAEKQTSADLKRMVFFCKDVEGMTKRDLEVDSALDLFGKLEERGVLSPAKTTFLGKLLGDIARFDCLEMWEEYQRGLASSKDTKKGQGSSEHPDLEEFLSDDYLLKLSKEIHAKDREPLGIHLGIKELSKYEISHPGNLQGQVLAMLKDWKGDTMTDTKSDEKQVRFLGDCLAKTGRNDLKFKLLKAHNLSPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUL3</accession>
    <name>A0A8B7YUL3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110982354</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096397.1">
        <property type="nucleotide sequence ID" value="XM_022240705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUL3"/>
    <dbReference type="GeneID" id="110982354"/>
    <dbReference type="KEGG" id="aplc:110982354"/>
    <dbReference type="OMA" id="GCPAEDQ"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022096397.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24917" checksum="8B336E94FD156260" modified="2022-01-19" version="1">MEDPNNNEDFAFVPDFMMPDLMTSKDLSIGLDEQSVPVFHHEGCPAEDQLSPVTMALQAPHLPVFDSGSYGTSGSGPDHQLLNRHQTMEIGKDLHDQTYDTAFFPHLSANWGATPANNGEPAAHHSASSSSSLASALNCPLCRRSFKHKLSLTNHQRSHSAREPHLCTICGETFKYKTNFKRHWRIHAKEMKTCRYCGTNMDSDYDLVQHEKAHRRQEKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUX2</accession>
    <name>A0A8B7YUX2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110982769</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022097109.1">
        <property type="nucleotide sequence ID" value="XM_022241417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUX2"/>
    <dbReference type="GeneID" id="110982769"/>
    <dbReference type="KEGG" id="aplc:110982769"/>
    <dbReference type="OMA" id="VEITIIW"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="17"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="112"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="218"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="315"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="413"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="779"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="810"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022097109.1"/>
        </source>
    </evidence>
    <sequence length="1072" mass="119203" checksum="B4131117016B8B92" modified="2022-01-19" version="1">MNDVIFFLVSTVSSFIPTVNLQESDVTSDSIRFTWDEVPCEELNSPLSYYNYKTELRNQATGELVSSDLRYQVKRATQLTPCTTYSFKVAVRNTIGIGSYSNATEVTTSTVAPSQVQALSVDSVEDQPTALRVRWNQPSGNCPIDNYTIHYDLVWLSQCEIPESNRTLVGTTEGTEYSITGLFPHSRYKVDVTAKTSAGEGDRSYVYADTADAAPSEPPRGITNTATLERGLRFEWQPPSCQGRRGIITGYGYRLLDLEERGVNITENTPSNETQADVSGLVPYTLYSFQVLARTSAGDGPYSEAIRLRTAQAKPPQVPMVTTPSGNATSITVRWRRPDPPHGIIIAYYIRYGIVLQGNEEVKVTEALNDTVLEFVLTGLVADSNYSMQVQAETIVSRGSWSEPSFCTTLETVPSAPVGVHLDNKGDNCLVTWNPPEQGDVISYKIFRNAYLIPRDGSDDLDPIPDLNASDFVVTDDTTPRTYSVKKSDLATYTRYRFQISASTQAGEGSVSKETNSICDSPRAAPVELQQPMISDTPGNPVFDRTFKVTIGSISQRNGPVSCVEITIIWLKTDENVEGTDPDILYHPDLYRSYEDAKVTQGLPYVAVVLEGNDLIESKEVTIGSGGKSECQSTGSRRKRRQAPMIHEGENGALTPDSKYTAFIRAYVVLDNGMEDYVTSPLLQPVWTAQATDFTAIIAGMCVLSVVLLVVLIAFGVILRRRRAKSFQPSPTVVTTNVEMDEIDYERPIKPDDRQSTVYEDVGLPTWALRWEILWKNLVVDDKVLGQGNFGEVRLGTVNVSGKKTETAIKVLKGRASETDREDFMEEFRTMTNIGYHPNVVSLLGACQHKDVLYVALEYLPKGDLRSYLRTGRLQSESDEGALSPDQLIKFALDVAKGMEHLAMSGVIHRDLAARNILLGETLVAKVSDFGLSRGEDIYVQMSKRRVPTRWLAIESLSSRTYTTQSDVWSFGILLWEIASIGGTPYATIATKSLLARLMQGYRMPKPINCDKEIFSLMLRCWEEDPSNRPSFSDLVRIFSDLSDKKVQHTYMAVDRAHYANFSVIRPERDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVC5</accession>
    <name>A0A8B7YVC5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110982378</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096435.1">
        <property type="nucleotide sequence ID" value="XM_022240743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVC5"/>
    <dbReference type="GeneID" id="110982378"/>
    <dbReference type="KEGG" id="aplc:110982378"/>
    <dbReference type="OMA" id="HFIVESK"/>
    <dbReference type="OrthoDB" id="6434680at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF6">
        <property type="entry name" value="DOUBLECORTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096435.1"/>
        </source>
    </evidence>
    <sequence length="647" mass="72612" checksum="78E77D06B67616D5" modified="2022-01-19" version="1">MESQEGNIEHLPTVIEKDNIPSDRDEIPSPDLCRKFQHLSQIAGKIPDIREDVDVLLMIGRNCPEPLKAEARLRNLLRTLNRKTELMREYQAFLGKILDMKHATPVQIDEPTPANGTTWYLPHFPVRHPKKPDIRVVFDASSEFNGISLNQVLLQGPDQMDTLLGILLRFRVDKVAVMGDGEKMFHNFHVTPNHRNFLRILWFQDNNPEKAIVHHRMNVHLFGNISSPAVATFGIRRIARECESTHGKDMSEFIHRDFYVDDGLTSQPDTETAISLVLRTKDAIATVLATTLSRTAEAELQGRVAINETVFYSDSRVVLGRIANESKRFHVYVANRVHKIHAASKPCPWHHISSGQNPADLASRSVPAGRLNDTNWFRGPDFFWQSGPLPAGTTSANTEHTYDENDPEVRKQVSASATNVEGEANKLTLQGDTPHLGCACFSRFSSWPRLERAVGNLIRRIQTFKAGRDDTSETSRDEVQRVSSNLSSAQLQQAERAIFRAIQSESFSDEVRTLKKARTEPNSTISRKSPPSGLAPFLDDDGILRVGGRLKRGNFDLGVCHPIVLPKGDHVSRLLVEHLHREVRHQGRHLTTGAVSHAGLWILGLHKLVRGVINQCTTCRRLRGKPLNQIMGGLPGTDSRQHHPSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWS5</accession>
    <name>A0A8B7YWS5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110982659</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096940.1">
        <property type="nucleotide sequence ID" value="XM_022241248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWS5"/>
    <dbReference type="GeneID" id="110982659"/>
    <dbReference type="KEGG" id="aplc:110982659"/>
    <dbReference type="OMA" id="MGKAVCF"/>
    <dbReference type="OrthoDB" id="7108654at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096940.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="32892" checksum="7129CEA27AD66A36" modified="2022-01-19" version="1">MRLCLPSKMTSRFPRLVLCTTLYLLAYALALEKGEILDMSYGFDDDSLAFPGLGFFEFTIQARGPTGPLPWLEMNSYGTPEHIGTHLDAPAHGSQGKMRVDDIPLSRFTGPAIRVDISEKVKQDRDYGMTVKDLQDWEVVHGRIPDGSLLFVYTGWGAFYPDRLAYFGTTRNDTYLDEQGRSILHSPGVAPEAATWLVANRKISGLGLDAPSLDRGPSSDFMTHQILFGANKFGIENVANLDKLPNTGAKVYAFPMKIIDGSGAPVRIAAMLDEADISRAVTFPPAITTCFICLASALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YX64</accession>
    <name>A0A8B7YX64_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear valosin-containing protein-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110983182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097918.1">
        <property type="nucleotide sequence ID" value="XM_022242226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YX64"/>
    <dbReference type="GeneID" id="110983182"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000600">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038100">
        <property type="entry name" value="NLV2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031996">
        <property type="entry name" value="NVL2_nucleolin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16725">
        <property type="entry name" value="Nucleolin_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="324"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="666"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022097918.1"/>
        </source>
    </evidence>
    <sequence length="933" mass="101875" checksum="0FEF96E940DA0EB3" modified="2022-01-19" version="1">MSTENPGKRHLPFYTGDRQLARRVQEHLDSFPLGCYVDPVLIADDLQQTYRQYGRRKRLAFRKTVQRVCDWVAKQKSKQSGLDVMEQRHLSKRRKQDKCNGEGSLSRQDREALNDGSSDSFSDDSEDYVESKDTNMVNAALSKLYSKGTPSASSSPSPGLKPQTSNLAGTPDTTPGRPPGRQGKADSDGDSMELGNLSMDHLDDGEDVDDAPSRRGREMLLPRTLATEATPIPSGSSTPQTGMKRLKDKKRKSSNQTMMEEESTAKKGRMGQERGRKAKKIVEPQQSTVTFSDVGGNDETLHELCKLLIHMRHPEVYQQLGVTPPRGVLLHGPPGCGKTLLAHAIAGELQLPFLKIAATEIVSGVSGESEGNIRDLFEEAMGLAPCILFLDEIDAITPKRETAQREMERRIVAQLLSCMDELSTSPLHVLVIGATNRADSLDPALRRAGRFDREICLGIPGVKERERILQVLCRNLRLSQDFSFASLSSLTPGYVGADLMSLCREAAMCAVNRIFHDLQVPSENVQPSPISDSTSSRLCIEADNGGENRASQSAQTGKQTSPGTIQDVKEAEQADPKPSYHLALSWLKDHSPLTEEQLDELYIEMKDFEEALPHVQPSAKREGFATIPDVTWDDVGALHSIREELSMAILAPVRNPDAFKMLGLTSPPGILLAGPPGCGKTLLAKAIANESGINFISVKGPELMNMYVGESERAVRQCFHRARNSAPCVIFFDELDALCPKRSDSAESGSSARVVNQLLTEMDGLEARKQVFIVGATNRPDIIDPAVLRPGRLDKTLYVGIPSPEDRVAILKTVTKNGTRPPLADDVILENIGHDDRCDGFSGADLAALVREASMAALRVVLWSVPTGTNPRGGGTERGTGVSQVAVTAADFESAFAKVKASVSKKDRERYRKLRLNALDLSDEHKAAAPTCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ23</accession>
    <name>A0A8B7YZ23_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110983193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110983193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097942.1">
        <property type="nucleotide sequence ID" value="XM_022242250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZ23"/>
    <dbReference type="GeneID" id="110983193"/>
    <dbReference type="KEGG" id="aplc:110983193"/>
    <dbReference type="OrthoDB" id="10035901at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47526:SF3">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022097942.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="29310" checksum="DCD8E3B50881C237" modified="2022-01-19" version="1">HLTFLFRIQATCKHISGLLFAVVEAVEQGKNSSCTSQQQAWGQGPKKGQSVHDCQFAKSIKRVGVKADVTRQTSRSTRIYRSEFEPRVLAHRNKRPVSAFNIDALADITNGNCGMLMYVKQQEEFETTQGVLTVKEAYQKASADDVIKGLELNHHQQILLANDAKKQTSSTLWTQHRIGRITASVAGDCAASIKENGLSGHSQIARAMGYYDSPHSSALTWGRMQETLARKQYVAWHRLHYKHKGVTCEETGLWVYVMKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZI2</accession>
    <name>A0A8B7YZI2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein MCM10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110983650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098764.1">
        <property type="nucleotide sequence ID" value="XM_022243072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZI2"/>
    <dbReference type="GeneID" id="110983650"/>
    <dbReference type="KEGG" id="aplc:110983650"/>
    <dbReference type="CTD" id="55388"/>
    <dbReference type="OMA" id="TFNRIPN"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000174">
        <property type="entry name" value="DNA replication licensing factor mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015411">
        <property type="entry name" value="Rep_factor_Mcm10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056791">
        <property type="entry name" value="Znf_Mcm10_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09332">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24863">
        <property type="entry name" value="zf-CCCH_Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01280">
        <property type="entry name" value="Mcm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="44"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="183"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="656"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="770"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="863"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022098764.1"/>
        </source>
    </evidence>
    <sequence length="986" mass="109225" checksum="1642BD4C717AF551" modified="2022-01-19" version="1">MSDEEYAYDDLDSLTALLDEEEESNPYTLLSSLSGIRKLTPSMEYSTQNGLSQISSGSSHDTKRPSPSQKTFSRGSQRSCRGQGSSSTQGQGSSSGENKETDESKSKEQLMDELKQLREQMKLLQSQQSSGDVSQTDQPKETFSEAITVPVEVKRVTKKKTAAADSKALGETRQYSTEEIGSMAGFTDTPTLSNPGDWEDWDEEERSTTEQKSTLFGKSSKRVAHTPKNTTSKPDKVSPYKCELCHELLDTRTALDVHMFKHRKESPHNCNVCGMSYHSKLKLEAHGRTHKSSATPTSSSSVSLGKLTSAAQGRRGNGIGGRGPVTGTAKKEDGHVETNRYSQIRILNPLVSSARLDAMMEGRKMLRLSILQKYLDTGPNKGDWVTMGVIVSKLPPKTSSKGKTFSIWKLSDLSVCDQTITIFLFSKAHDNHWKTVQGSVIGLLNASIMPPKDNGQDEGVSLSIDHPDKLLLLGTSKDFGHCRGKRKDGKPCSMVVNMAVSEFCQYHVQSEYKKHSAKRSDLQSSYGGVQPKAFKKKLGTNIIYGGQTYNPVSASVVKSGSTSSSRGKKDTKVTLQNLGVKGAKEIEQEARESILTLHGHQNSEDTLVKMSGANPQFKEMLSVPSLGSQNLIRHMVKVEEVSKPITTISAKDLLKQHQDDMRARQASRSLGHKSLSSSTLSKPCLVESNKRPTSRNSSQKLNTEHKGQFSPSDTENKAPVLGRGFNEDDDIVFEADSPQNKNVFVRSAPPLQNFGKSRSAIEARRNAIAHVRSKGQIEKADPNQVGGRKKGSLSPRKQKAVKRRVEEDLNRSLEDPSNAESAGQPAKKQKRSFLGQEVNLSQDELKAIVGAKSKHSGLLAEVQAEMEEQYFQQLEKKERLENMMDSIREKKCKVVSCKKCDYTWFTPSSLCASESHPLTRHEATLRYFKCKDCSNRTITFNRIPNKSCRICGCTSYERASMLKERKGPVLDSERLLIRGEEQKWVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z081</accession>
    <name>A0A8B7Z081_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Uncharacterized protein LOC110983315 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11" type="primary">LOC110983315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098180.1">
        <property type="nucleotide sequence ID" value="XM_022242488.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098181.1">
        <property type="nucleotide sequence ID" value="XM_022242489.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098182.1">
        <property type="nucleotide sequence ID" value="XM_022242490.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098183.1">
        <property type="nucleotide sequence ID" value="XM_022242491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z081"/>
    <dbReference type="GeneID" id="110983315"/>
    <dbReference type="KEGG" id="aplc:110983315"/>
    <dbReference type="OMA" id="PISHEAW"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="812"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022098180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022098181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022098182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022098183.1"/>
        </source>
    </evidence>
    <sequence length="1133" mass="127040" checksum="09CAFDE0427D6B05" modified="2022-01-19" version="1">MTHVTQRQLKMAAELDQMPPRRKPFCRQTAVTNNVDVADGPIFAVQTSKTGPTRHFRQIKAPCNHFSHDGCSKETSNKDLQQMLPNSKASQKNSSQLQMIRDIHCNGLNHQYTCKGVGGTIQLFVKYIYSEHLTRYDQLLFKQRSSITISYHHETCTPITWQKEPEKAPKRKDISDGLPSSAGAVLADISHRKDLSDVYPRRPESSGQPLLESYPGGGSQGKSLQTSLRRSSNSLVDEQFDSGDSGRQLSSSTSSSLDTQELEASSSDRTIPKIEVNGVVKQSLSESGRHKGEGFRKSKKSSGYGTGGSDEIPEGQHFSSVFLSSENSVNEEIHHPGSYEDERRSFRLSHFSSEGGEHSSPGHNFKLSTGERKVQCQDSDLPPDAAIWLFKQGTHRKIPSHIAKIDIDNLSHSQCDRIFMEILQANPQIPIPRCECFDQSSLKKERYSEQVFTEEEENKRCARACTCIEAQLDFLEKMALISKSWANDMPADADQSRDPSEATASSGEQLELEFSAESEPSLCHSSIRGDDEIDGKTDAPCHTSSGTVTRQTPSYASAYLPGTNTSPSYLNNGTNCLRPSASASHFNKAGIEMDGSDRRYPQKNTHGMEGSRTGHQPLANGYLAAQNHREQLQAEASPLRGATGFTDHGITSGSSDARHMEQRAPFEEVVANGYAEPSHGKRSTGFKDHCVGCNTMHNGRISHTSYRMVSSQQPSNGCTNPVGRQDYSSQLGDPERAVYCKKRCQDNRCQDSSCLLGKRQILKLGSLFLENRIKDGGHIMDCLWQHSSRCKEVECIVPFCAVFRRRPWLPFEEHFSQMCRGSISLDLQMELVNIMTKQLRLGDFLICPINPVSSELWKTACVVEGQFLGDFGDFNILRARIAFQDKARHDVVIKKALSHPDLKKLYFNINQKSSPYITQSYWCSDISGSEMLVCSTYYPEMESLHNAWMVQELTFDICLTLLQQVLYAAMHLHSTYKIVYLNWKCSNVLWDGRTTGENIKLCNFNKVVQIKPGCVVQCPANIIESFDPCFTAPEVFCRTPLSYNSDVWGIGCLLYEMLYKKSPYQDHTHLSPAEMRQLVRDDQIQPDLPCDNSQLLALLCDCLQRKMCERLTTEMFLEKVDDLLSAKTAEAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0S4</accession>
    <name>A0A8B7Z0S4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="27">Dynein beta chain, ciliary-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC110983882</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099208.1">
        <property type="nucleotide sequence ID" value="XM_022243516.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983882"/>
    <dbReference type="KEGG" id="aplc:110983882"/>
    <dbReference type="OMA" id="KYLTDQV"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA_6"/>
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        <property type="entry name" value="AAA_9"/>
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        <property type="entry name" value="AAA_lid_11"/>
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        <property type="entry name" value="AAA_lid_11_sf"/>
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    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
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    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
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        <property type="entry name" value="Dynein_2_N"/>
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        <property type="entry name" value="Dynein_AAA1S"/>
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        <property type="entry name" value="Dynein_AAA5_ext"/>
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        <property type="entry name" value="Dynein_C"/>
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        <property type="entry name" value="Dynein_C_barrel"/>
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        <property type="entry name" value="Dynein_HC_stalk"/>
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        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
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        <property type="entry name" value="Dynein_heavy_linker"/>
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        <property type="entry name" value="Dynein_heavy_tail"/>
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        <property type="entry name" value="Dynein_linker_3"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN"/>
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        <property type="entry name" value="LOW QUALITY PROTEIN: DYNEIN BETA CHAIN, FLAGELLAR OUTER ARM-LIKE"/>
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        <property type="entry name" value="AAA_7"/>
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        <property type="entry name" value="AAA_8"/>
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        <property type="entry name" value="AAA_9"/>
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        <property type="entry name" value="AAA_lid_1"/>
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        <property type="entry name" value="DHC_N1"/>
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        <property type="entry name" value="Dynein_AAA_lid"/>
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        <property type="entry name" value="Dynein_C"/>
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        <property type="entry name" value="MT"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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            <begin position="67"/>
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    <feature type="domain" description="Dynein heavy chain linker" evidence="17">
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            <begin position="1814"/>
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            <begin position="2464"/>
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            <begin position="2801"/>
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            <begin position="2968"/>
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            <begin position="3784"/>
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            <begin position="4590"/>
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            <begin position="4808"/>
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            <begin position="1174"/>
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            <begin position="1488"/>
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            <begin position="3623"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF08393"/>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF17852"/>
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        <source>
            <dbReference type="Pfam" id="PF17857"/>
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        <source>
            <dbReference type="Pfam" id="PF18198"/>
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        <source>
            <dbReference type="Pfam" id="PF18199"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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        <source>
            <dbReference type="RefSeq" id="XP_022099208.1"/>
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    <sequence length="5760" mass="641746" checksum="49E774DE7A38108B" modified="2022-01-19" version="1">[encoded data, 5760 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1L5</accession>
    <name>A0A8B7Z1L5_ACAPL</name>
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        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 26 27" type="primary">LOC110984019</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26 27" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022099492.1">
        <property type="nucleotide sequence ID" value="XM_022243800.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099494.1">
        <property type="nucleotide sequence ID" value="XM_022243802.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099495.1">
        <property type="nucleotide sequence ID" value="XM_022243803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1L5"/>
    <dbReference type="GeneID" id="110984019"/>
    <dbReference type="KEGG" id="aplc:110984019"/>
    <dbReference type="OMA" id="CMSEYWM"/>
    <dbReference type="OrthoDB" id="419734at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="23">
        <location>
            <begin position="28"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022099492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022099494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022099495.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="52592" checksum="CC7F504FADB4F005" modified="2022-01-19" version="1">MASVQESTLEKPAVRIRRYRLVTVEPVVFLMLAIQGGFVALRTLYIEHRLAVSYNYTLPTGDVNGTCGAANATKDPTQEQIESKTALWVAYMKGVSVALPLFGALLFGAASDFIGRKPILTVSASGHLLAAALFLCVAYFNLPLFCLVVGEIILGICGDSVVPESAAYAYVTDVYQGNERSFRIFLVDVLIYLGFGASQIVVTTILQLTASNFSIAYLTIFVTAIVNFLYVTIPRVVVESVDKRPFSRGVFRDLFAQIYWLFKNNTNGRRPRIILLLANMILYELVYEAVYSVITIYGLGPPFCWSETFVGVYNVIVNIAPAVASILALKLLGLCMSEYWMVYLGFLSGIALMITTSLAKTTALIAYVAPSVGLLRVLPTPILKFLATQLVKVDEQGSLFGAVAVLSSVGRALSPVVMNGIYSYTVKIGHPTVTFYVAGGILVIPLFINGYLHARQRWPSSSYQQVTTISDENGHDRVTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2H4</accession>
    <name>A0A8B7Z2H4_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">Calmodulin-like protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099818.1">
        <property type="nucleotide sequence ID" value="XM_022244126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2H4"/>
    <dbReference type="GeneID" id="110984197"/>
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    <dbReference type="OrthoDB" id="435273at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
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        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF45">
        <property type="entry name" value="CALMODULIN LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022099818.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="18001" checksum="9E85800DAD856D7D" modified="2022-01-19" version="1">MAHFFTQKQIDEYKECFLLYDRSRKGYIRGDDLVVAMRSLDAHPTVDEIKQYRKEYEHGGKVKFDDFLQIMYKHQEDPLKEILEAFRVSDPQDRGFIMANEFRHIMTRFGERLTDKEVDAVLREFGVQKTGFVKYKEITKQVLRPIPDTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3D6</accession>
    <name>A0A8B7Z3D6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Paired box protein Pax-6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110983923</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099290.1">
        <property type="nucleotide sequence ID" value="XM_022243598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3D6"/>
    <dbReference type="GeneID" id="110983923"/>
    <dbReference type="KEGG" id="aplc:110983923"/>
    <dbReference type="OMA" id="IVEMAHC"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000307">
        <property type="entry name" value="Eyegone, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF41">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0563">Paired box</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="14">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="269"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="271"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="202"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022099290.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="44006" checksum="BD5556719D4D8724" modified="2022-01-19" version="1">MHFGVDAGFNQLGGMFANGRPLPETMRHRIIEMAHCGARPCDISRQLLVSHGCVNKILGRFLETGSVRPGTIGGSKPKVATPTVVEKIERYKQENPTIFAWEIRDKLISEGVCTTSTVPSVSSINRILRNRAAERAAAEYARATEQAYLSDYATAWTHYAPPYAIGPGMRITDRRLDPRQTLRACCSGFLCGSPYGTYPPSILPSSNSPSPLATESQSDVPFSASSSSASPRPRSPSPATPVSSSESKVYQPELDPSPYRDAISEEQRRKLRRSRTTFTPEQIEILEKEFEKSHYPCVSTREDLANKTTLSEARVQVWFSNRRAKWRRHKKIGSLQSHAGPLLSHPSHNTLYPTSVALPRAYKAVELGGGKATLRPSMSSAFTPLSLAKATAAASSASSSGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3G7</accession>
    <name>A0A8B7Z3G7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110984355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100178.1">
        <property type="nucleotide sequence ID" value="XM_022244486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3G7"/>
    <dbReference type="GeneID" id="110984355"/>
    <dbReference type="KEGG" id="aplc:110984355"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="666"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022100178.1"/>
        </source>
    </evidence>
    <sequence length="696" mass="77921" checksum="9661E17869506015" modified="2022-01-19" version="1">MSSFEKEKALQTEIADMDGHCLDDGASNGTTKAALANHVALVNEDDSPVKAKADSKTDSKMDENQERGNWSNHLDFMLSCVSYAVGLGNVWRFPYLCFSNGGGAFLIPYCIMLTFAGLPLFFLELSFGQYGSCGPISVWRALPLFRGVGYGMVIVSALVAIYYNVIICYTIFYIVKSMTTTLPWVGCNHQWNSEFCSTLVNECLEHGGIVTVENECISIANMTTAELNQYNVTADGNISNYKDPLYNMRVPPSEEYYRQGVLHDSGDIFKSGYVIWELALCLLLAWVLVFVCLAKGVKSSGKVVYFTAIFPYVVLLILLIRGVTLEGYQEGVKFFITPRWELLKHPKVWKDAAVQIFYSLSASWGGLITLSSYNKFHNNCFRDAMIVPVINCATSIFAGFVIFSIMGNMAYELKVPVSEVVQEEFGLAFIAYPEAVARLPISPLWSLLFFFMLLTLGLGSQLCIVETVVTSIVDEFPRYLRSRKFWVLAMYSTLGFLVGLNCVTQAGNYWVILMDKYAADFALLIFGLCECIGLGWLYGVRRFFNDIRCMISDRLVDFPLFKWWGVQWCALTPAILSFVLLFNWIDWEVPKAGEKDFPMGAHIIGWVMISSSISAIPTVMIYELVFKGEGNIIERFRRATTSKPSWGPALKLHRLEAINAHKAHGTVMGGDLEPGTDKYDDNDVKYSPANADESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4A0</accession>
    <name>A0A8B7Z4A0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAX3- and PAX7-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110984508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100458.1">
        <property type="nucleotide sequence ID" value="XM_022244766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4A0"/>
    <dbReference type="GeneID" id="110984508"/>
    <dbReference type="KEGG" id="aplc:110984508"/>
    <dbReference type="CTD" id="94104"/>
    <dbReference type="OMA" id="MKNICLW"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GCF C-terminal" evidence="6">
        <location>
            <begin position="585"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022100458.1"/>
        </source>
    </evidence>
    <sequence length="902" mass="102439" checksum="3FA2FCABE84C8626" modified="2022-01-19" version="1">MMLKKKRNIRQREESSDGEGETTNQIPFLEETYHTQVKNVQKSLQEKLEKKSKKKDGKSGGAEGGGVGVGSSGSLLSFDHDEEEEGEVFQIKKSSHSKKVARKLREQARKERQREELSRLVKESAEKGKKLSDVKGNGAANKQLGTRSKPQDRAELILNGLEAEVAAMEEEDRRELEESVPLVAPGVIPDAATIFAARKRRQIARETGGRADYIPLDDTQRYRNTSGKTGREESRLVREDDNDASGSDEEGRVSFTMKQQTSRQRMQDVISENAEDGSDQDKDHDEELQRWEQEQIKKGTSVPQAQDTAPSSSAAAAAAVAASYYYQQEFPYGQPANQYAAPVGGAYGLGAEQQPIVHALNTTPMCEMPSVTTEQVKKKLKDWFESVKDVHRAHERELDQLQERLESSADTSISLKDTQGDVTGQYRFFQEMKGYVKDLVECFGEKVVIIDGLEMAMTVLLKSRADALAQRRQTDIRDQSVEFTGMLQRAALSANFDSGSKAKSEDITKQRRAAEREARRARRRRARESQSAEETGSHMEGMSSDDEQRESDADKFNKERDRIMAESQQVFEDVMEDYHAISFILGRFQRWKFQHGESYREAYISLCLPKLLGPLVRLQLLDWNPLESDCHDLEEMPWYESMLFFGFQQSEDIDSEDLDASLIPSLVQKVVLPKLTDMVKEVWDPVSSTQTNRLVSLIHKLVEDYPTVNSDSKNTRDLLKALVERMRRTLDEDVYMPLFPKDMLEKSAAANSFMQRQFWSCVKLLGNLLLWHGLISEDHLLELAVDGLLNRYMLLSLQNSDVNDDSILKCERIVATFPPQWFKDLQGDETLRQLEPFCRYLEHAAESLKRQGTVGNDIERRIARSGLKAVTKLLVTIHAMDHALNISQGLSLRDMKEILEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z621</accession>
    <name>A0A8B7Z621_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermine synthase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110984481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100402.1">
        <property type="nucleotide sequence ID" value="XM_022244710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z621"/>
    <dbReference type="GeneID" id="110984481"/>
    <dbReference type="KEGG" id="aplc:110984481"/>
    <dbReference type="OMA" id="ICGKEDY"/>
    <dbReference type="OrthoDB" id="5953636at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016768">
        <property type="term" value="F:spermine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000197">
        <property type="entry name" value="spermine synthase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015576">
        <property type="entry name" value="Spermine_synthase_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46315">
        <property type="entry name" value="SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46315:SF1">
        <property type="entry name" value="SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="4">
        <location>
            <begin position="125"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022100402.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41831" checksum="DFF0A2056CABD660" modified="2022-01-19" version="1">MASTTLFNFSVSSQVFLNPVDWKTVQQGMRDIFLDSGFDGCPHTVSFGANNGSLILYSGPDGRSAVVQSYAEGLITVNMQEPSKQEHLLMAEQLCTLEKRLATLLGCEKSKRFPRIQRSISPCDPYIPTVDNRLVEYDFDRIVFEEDSKYQNIKIQHSPQYGNMLILDNDPNLAESDIAYTKAITGNGRQDYRGKEILVLGGGDGGILHVLRQEDPAMIVMIEIDEVVINAATKHLRGICFDSMDELEGSNYKVIVEDCVPVLKQYATEGKQFDYVINDLTAIPITTEPQGDQWDFLRLILDLSMKVLKPTGRYFTQGNGANMRDALAMYEQQLGKLSFKVEFSKETVCVPSYMEMWVFYEVWKQQGQNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9N4</accession>
    <name>A0A8B7Z9N4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 54-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110985575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102384.1">
        <property type="nucleotide sequence ID" value="XM_022246692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9N4"/>
    <dbReference type="GeneID" id="110985575"/>
    <dbReference type="KEGG" id="aplc:110985575"/>
    <dbReference type="CTD" id="129138"/>
    <dbReference type="OMA" id="NTHELDR"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022102384.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34177" checksum="A16D0D1867275CB4" modified="2022-01-19" version="1">MNDARVASPVSESGDMFPQPPCGIVGSSPGKSNLSPGSAVDTDSKMNLNPRIDLNFGIRNWSSELAAASVNFSYFNPFGDPENLSSETELHDFVGKIRRPRSRLHCRRGAVVLTQNPLGKDLKGERKLRHAASKGDVEEVRKLLEEGVNPNRPDDKGRAPLHFAVTKRCHEMVQVLIDKGADVNQKDGLGNTPLHLAVFSSHMGVATTLLESGANTHELDREGHTPIHLARSRLRHIKDVSYDISCSQLQDEVLQLVAMLKVYMSSMGLSEHMRRLDQLTLQVQEAATNEQVDAIEDILNSFTTLSLQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9N8</accession>
    <name>A0A8B7Z9N8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA demethylase ALKBH5</fullName>
            <ecNumber evidence="4">1.14.11.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alkylated DNA repair protein alkB homolog 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110985574</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022102383.1">
        <property type="nucleotide sequence ID" value="XM_022246691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9N8"/>
    <dbReference type="GeneID" id="110985574"/>
    <dbReference type="KEGG" id="aplc:110985574"/>
    <dbReference type="CTD" id="54890"/>
    <dbReference type="OMA" id="DEVTHCI"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000002">
        <property type="entry name" value="RNA demethylase ALKBH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032860">
        <property type="entry name" value="ALKBH5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32074">
        <property type="entry name" value="RNA DEMETHYLASE ALKBH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32074:SF2">
        <property type="entry name" value="RNA DEMETHYLASE ALKBH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="16">
        <location>
            <begin position="120"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="277"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="304"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022102383.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="46256" checksum="DABBA1FFE86D297A" modified="2022-01-19" version="1">MTASCSDLRQKLDHNHHSHYENASFGSRRRRPFDVKYDPSRRRSHEFGRQGNYEHRSSFEDDMEEVKKIHSGIKQYQLFSDAESKEIEKKIDEVVQNGLEGKYRLHTVDRAPLRNKYFFGEGYTYGAQLSKRGPGQERLYPKGEVDEIPSWIYELVVKKLEDNNLIPKGFINSAVINDYQPGGCIVSHVDPMHIFDRPIISASFLSDAALCFGCKFSFKPIRVTKPKVSLPIARGCVTLLSGYAADEVTHCIRPQDVKARRAVIIVRRVFEDAPRLPAEPSLKSLPAPSQDRGHNPRHGHHNNRGSSSSDRARSWGSSFSPAAEAKSSKVRSAVALVVEGKQSEANKSPARNSEAAKDTGGEKEGKRVTLKRPALDGPSKREDPQHQGSRPKAEPVPHKKVKINRQQPFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAT5</accession>
    <name>A0A8B7ZAT5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UPF0728 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0728 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100356.1">
        <property type="nucleotide sequence ID" value="XM_022244664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAT5"/>
    <dbReference type="GeneID" id="110984423"/>
    <dbReference type="KEGG" id="aplc:110984423"/>
    <dbReference type="OMA" id="VEHRTYR"/>
    <dbReference type="OrthoDB" id="10003460at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027885">
        <property type="entry name" value="UPF0728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28448">
        <property type="entry name" value="UPF0728 PROTEIN C10ORF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28448:SF1">
        <property type="entry name" value="UPF0728 PROTEIN C10ORF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15092">
        <property type="entry name" value="UPF0728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100356.1"/>
        </source>
    </evidence>
    <sequence length="92" mass="10283" checksum="B56672FEDC622CF5" modified="2022-01-19" version="1">MPKNALVTVRYGPYRACGIVEHRTSRLDGLQALLTGDGHTVELCPIEDWNVVELIVNGEMVYQCDITEMDYGSDGQLDKLCHEALEAVRKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB07</accession>
    <name>A0A8B7ZB07_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extensin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102000.1">
        <property type="nucleotide sequence ID" value="XM_022246308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZB07"/>
    <dbReference type="GeneID" id="110985343"/>
    <dbReference type="KEGG" id="aplc:110985343"/>
    <dbReference type="OMA" id="LAGWENH"/>
    <dbReference type="OrthoDB" id="10579178at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102000.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="18892" checksum="79476011D625782B" modified="2022-01-19" version="1">MNPAYPPQPYHQPTGPPPPYSAPTNAGQPPPIGFNPNLYASPQPAYAPTSHYAAAAAPPVAQAAPPPAAYSAYSSAPPPAPAYITQAAVPYNASGAYNPNQPTYIHPPPQQPVSNLTVVQPTRTVYVANPGPSPGTSAGLGFLAGAALAGSHHHHHHHGFGHHGAFGHHHHHGFGHHGFGHHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC46</accession>
    <name>A0A8B7ZC46_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phylloquinone omega-hydroxylase CYP4F11-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985991</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103238.1">
        <property type="nucleotide sequence ID" value="XM_022247546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZC46"/>
    <dbReference type="GeneID" id="110985991"/>
    <dbReference type="KEGG" id="aplc:110985991"/>
    <dbReference type="OMA" id="WKAQESK"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022103238.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="58075" checksum="FA53AAFB1DA030FC" modified="2022-01-19" version="1">MLWQVVFLALVLVSLMVFVSVRKSISKRHALKKLPSPPGAHWLYGHDRQGPFDPGYKWLIDTVTAFPRIYTLWLGPTPLPMLVHPETIKPLLMGTVSNKKSEFYELFFDWVGEGLGTAEGAKWKRNRRLLTRSFNLDILRTYTPVSNDCVEVLLEKMNQAAVEGQQFEMYSGLVLCTYDVILRTACSYKSSCQIRQIDQENGFNVLSACEALLQFIQLRQYSNRLLLIPWIFRLSANYSEYRNAFQYLRKFAGKLVEERKKELSEKADAGDPITKPRDFLDTLVMARDEEGSGLTVKEMVDEVNTFLFAGHETTATSMTWFLYFLSKHPEHQTKIREEVEEILAGRDSERITVKDLSRLEYMTMAIKESLRMMPAGPLISRTLTAPYTVDGVTIPQGTMVGICLHQLHHNPTVWGDDHMEYKPSRFLPENVAKMDPFSYSPFSAGSRNCIGQQFALNEMKVFTARILKRFRLKWVEGEPDLMPSMTFVSKPMKPLYINLEAMPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZED7</accession>
    <name>A0A8B7ZED7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acid-sensing ion channel 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110986456</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104023.1">
        <property type="nucleotide sequence ID" value="XM_022248331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZED7"/>
    <dbReference type="GeneID" id="110986456"/>
    <dbReference type="KEGG" id="aplc:110986456"/>
    <dbReference type="OMA" id="GQFHHVT"/>
    <dbReference type="OrthoDB" id="8065060at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF222">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022104023.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="55770" checksum="CA3C3F0F8D2489FD" modified="2022-01-19" version="1">MGCYKRCHLVEWARDVSDLHGLKHVAGSGGVLRRLIWAVVTLAALGFFLYQTALSFISFFEWNHVTKVDINYADELEFPAVTLCNFNKYRESAWTERDLKNVGTHLGIIDEDHNLINPHLYTDEFKQNLAAVNWTALEVEEDYDMTEFTNRTGHQLDEMIVECTWKGSPCNSQDFHHVFSHLGNCYTFNHVELDQDRHSTISAGAANGLKLTLNIQEEEYTPSNDLDGAAEDAGIKWMLHHPSEPPYVKELGFGAGPGHHTFVATRHEQISSLPFPYTMCEEDGSLKYFDHYSIQACRIECETDLVVDQCGCRLVEQPGTAPVCNPAESHECAHVVLVQAVTGETESSCDCKSPCELEVYPFTTTNVKLRANFIETIYSNSTTHNFTAEYIENNLVLLSIYFEALNHEVIEQLPEMTVFTILATLGGNFGLFLGGSVLTVMQLLEYLFDEVTASCASKGSSNRVGDSRANLTGKEKDVENAEDGISIIDMGKDKSKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEL4</accession>
    <name>A0A8B7ZEL4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cystine/glutamate transporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110986104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103437.1">
        <property type="nucleotide sequence ID" value="XM_022247745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEL4"/>
    <dbReference type="GeneID" id="110986104"/>
    <dbReference type="KEGG" id="aplc:110986104"/>
    <dbReference type="OMA" id="SPVECGI"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000095">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF375">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103437.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="49381" checksum="EED87394445FF87A" modified="2022-01-19" version="1">MKQDGRESLSIDLEHQTGEVCSLKSSKPSRDRVVLKRQIGLWGCIALVVGTVIGSGIFISPKGILQNTGSVGLSLLVWVACGVLSTIGALCYAELGTMIPRSGSDFTYLLESFGAVPAFLRIYTLIIAARSGTCAILMITAATYLTGPFFGECTIPRVLIQLLGTTVLGKTENFENSFTPVTDVPPERIPLAFYSGLFAYAGWQYLPCVTEEMINPSRNLPLGIVISMGIITVIYIMANVAYYVVLSPAELLASDAVALTFGERVLGSWSVLCWLAVALSCIGGANGTIFGASRSLMVSSQEGVMPEVLGMIHVHYKTPLPAALAFFPIVVCLLTFADVGAILNYMSFSNWLFICVSLAIIPYYRWKYPDIPRPFKVPVILPIIFIACGLFVMAVSLYSSPVECGIGAGITVTGIPVYLLFVWWENKPSWFTNAIDTLTSVLQRFLLIAPPDTKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFN5</accession>
    <name>A0A8B7ZFN5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110986334</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103812.1">
        <property type="nucleotide sequence ID" value="XM_022248120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFN5"/>
    <dbReference type="GeneID" id="110986334"/>
    <dbReference type="KEGG" id="aplc:110986334"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF47">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022103812.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="14904" checksum="9DE5A20948C4F9D2" modified="2022-01-19" version="1">MLHVFDCQITAAAMTWCLVGNTGAVHILPQSMIFVGRDNCDINIQSRSVDKRHSVINFDQYDKAFFIKDMETLNGFLSAPFTMWLPVTPPMAKGMLHFADKTTEERPLQEALFKSTARCCGLCGPKSSLSLQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFW0</accession>
    <name>A0A8B7ZFW0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110986295</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110986295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103750.1">
        <property type="nucleotide sequence ID" value="XM_022248058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFW0"/>
    <dbReference type="GeneID" id="110986295"/>
    <dbReference type="KEGG" id="aplc:110986295"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022103750.1"/>
        </source>
    </evidence>
    <sequence length="173" mass="19210" checksum="C1BF076860AA94F5" modified="2022-01-19" version="1">MSAISDIIKWGYEEYREFSISGKKQHSVQFLQNKNNGEEWDDVHLKQRVFSTGGIFLQPHRSRLTSKVLSVATGHIPERPYQLMALWGLRGDVCPRSLTSFCSPGDVLLETGPVNPLLAGNRFHGWLTTLHLLNCGRTCATTRHPASSCWGFCPPHSVCSSIMTSALPMGHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHZ3</accession>
    <name>A0A8B7ZHZ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nose resistant to fluoxetine protein 6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104485.1">
        <property type="nucleotide sequence ID" value="XM_022248793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHZ3"/>
    <dbReference type="GeneID" id="110986691"/>
    <dbReference type="KEGG" id="aplc:110986691"/>
    <dbReference type="OrthoDB" id="207378at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="562"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="259"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022104485.1"/>
        </source>
    </evidence>
    <sequence length="675" mass="75320" checksum="A9A81B5FC439330A" modified="2022-01-19" version="1">MWLSNGDFLNLDVLTTYNTHSIGNVEQCQVVKDWNPDAPFETQYCTLSYLALATTLRVGVCVPSSCSNADLKEVFGVIPALGKSAEFNCIFDYPWKTGAIVTLCLLCGFLLMVVIGTVYHLTCHRQIQASITETKANIEKMEKNLSEEKMTNSVKETQIELKASINGNSDWTGMMHLGKNGQTAHDNDGFIDVEGGLERTENVDPASNAPTYSASDIKGSKKKVIKMGFVDTLLMGFSALHNGAKVLNTEEAAGNLSVLNGIRVISMWWIILGHTFDIIPPYLDDPRYATTELFSSFWFSAVMYFSVSVDTFFFLSGLLLVYNTLKHLKKSNGRMNWALFYLHRFIRITPAYMICIAVFSTLIVHFNEGPGQIELFESSARICRERWWTNLLYINNLYPFPGSLGEQCVGWSWYLANDMQFFVISPVIIYLLYRYSKLGIGLIVALCLGSFGITAYLATYYGVSLGVSPPYNNNTVVVYGNAAADVIYMKPYCRIPPYLVGMVFGYIFYRLNGQPFKMNKWVNVIMWIAAVGAGLAIIYGPFRSDGEPLPQYAAVMYTTLSRAGFAVAVGWVTFSCVVGYGGPVNSFLSWSFWTPLSRINFCAYLLHTNLIYTFYSSAKSQYHFTYLMMASTVISNTVLSYAAAFILAIGVEGPVMGLEKALLGRRVGGKKKLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIF6</accession>
    <name>A0A8B7ZIF6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette sub-family C member 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110987168</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105344.1">
        <property type="nucleotide sequence ID" value="XM_022249652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987168"/>
    <dbReference type="KEGG" id="aplc:110987168"/>
    <dbReference type="OMA" id="NEVFMDS"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18602">
        <property type="entry name" value="ABC_6TM_SUR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002366">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="784"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="880"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="43"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="438"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="744"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1062"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="675"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022105344.1"/>
        </source>
    </evidence>
    <sequence length="1299" mass="143800" checksum="21FE563983E6C065" modified="2022-01-19" version="1">MSAEHLQQQLKKEFQEEQHKAAAKGHQPSLGKVIFRIYGARMAWAGIIKLAGDFAGLIGPLCVSGIVLYTANIYYKQDPGEKLGPHFIDVSEFIANGFVLMGITFIAVSFQSIAAQISLFYAIFYGMCLRSSIQTMVYEKSLSLSTFASIGEEMTTGQITNHMSTDAMNLLYMFQNFHFVWTVPFVVALVLYLLYEDLGVAALLGAVVYLIVIPLQLGIANFMAKHQKRALYFADKRLRYSNEILQGIKLLKSYGWEHPYLRVVENIRNQELISLLKMNVSYGLIGFIVSSSPLVVTLLTFGTYTTFTGELLTPEKAFSALALFNQLSAPLFILPLVTATLVNGIISTRRLQKFFIAQEIERSWNGRDWRDRVEGQGPSDYNEQGTTMDMIDDDVTCDDETTLMLPKMEISKNKRSDVYQATKNTKALINCLPESVAIKITNGNFTWEKASSIPVISDINVDIPAGKLTMVIGSVGSGKSSLVSAIQGEMTTLSGTVQFNEGTTSIAYAAQKAWLINSTFQGNVLFGKELDTKKYKKTIDVCALKPDIEILPGGDQTEIGEKGINMSGGQKQRISIARTVYSDKEIIILDDPLSALDVHVGSQVFHKAIVGTLLKKKRTVVLVTHQLQYLHHAHKIIVMKDGEVAHQGTLQDIIDEAPELYSEYQQAIKTVTESETEAEDIMSRMSDEEKREVFKRKTNQESSVESSRSKAGTKLIEEEEMEQGSVSYKVYAFYFRAMTWTMSIGFLAGCVGNAGFTVGTNFWLSEWSTAGITTDNSTIKPLSYYIAGYAGLSAGGVVTTFIGSMFIVSGAYIASRDLHISMFRNIAKCPMRFFDTTPLGRVLNRLAADTNILDMKLFQSMNVAVYSSVNYIGGLVVNSIILPVFLIFVVPMMVSYYFLAKFYVTTSRSLQRLDSVTKSPVFAHFSETLGGLPTIRAYGDQDRFYSTLIKKVNANNTAFLYLQTSNRWAVMRLELIGATGILIAGVGTIISSLNGTIEPSEVGLAVSYTLLVANYMKFAIRLAAETEMQMNAVERVQEYSGIANEDYQGTEPPESWPQRGEIKMNGIYVRYAKELDPVIKNLTVTFKSGEKVGICGRTGSGKSSLTLALFRIIDTCRGSILIDDIDISTVPLTTLRQRLAIIPQDPVLFSGTVRHNLDPENNGTDDELWHSLEISQLKDTVSQMPKGLDSEVSEGGENFSVGQRQLFCLARAFLRRSKILIMDEATASIDMGTDKILQEVVATMFADCTVLTIAHRVATILDSDSILTLADGEIVEYDTPENLLADHNSIFASLVNSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIF9</accession>
    <name>A0A8B7ZIF9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110986852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Lysosome membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104797.1">
        <property type="nucleotide sequence ID" value="XM_022249105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIF9"/>
    <dbReference type="GeneID" id="110986852"/>
    <dbReference type="KEGG" id="aplc:110986852"/>
    <dbReference type="OMA" id="SEYHVGC"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF7">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022104797.1"/>
        </source>
    </evidence>
    <sequence length="471" mass="51200" checksum="FB312BAC2610589E" modified="2022-01-19" version="1">MPGPSAEFIMPENADNIGEETQPAAHVERSEVQACIINRTLIGFFLLGLCTQLPYAIMNTAANTIVGSFNESSFVATVYGAGNGATVVVKNVNAFLLFRVSYGVRFLANSAIMLSGISGLAFSGSFALAIISIVLVGASHAFGENIALGYLSRFDSQNVAAWASGYGLAGLLGAVLYVLFGCLISEEYSQDMRNLDKWAFISVVPAVVVYLVASLHLIKEHCGFPQQRTSTQRLLNPISTDNEATPLLENTTDILRVQHESHPGETPSALNNDLSSNEETNCDRNESICMLPHAPPTKKIKAFLLQIKRCFKLVVWLAFNLAIVQFCSYNIRVSAAKAVKKQNGTKCPELYASLQLCFQAGVFASQSSLPIHKIKRVGLLTAVMTINMLLWVINDWFKFLPEALLPALMVVAGGLRGAVYVNVFYLIRTDGGFPDEDREMCANVAGIFLTIGLSLSCILQTVLFNTALLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIZ5</accession>
    <name>A0A8B7ZIZ5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alkaline ceramidase</fullName>
            <ecNumber evidence="9">3.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110986000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022103256.1">
        <property type="nucleotide sequence ID" value="XM_022247564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIZ5"/>
    <dbReference type="GeneID" id="110986000"/>
    <dbReference type="KEGG" id="aplc:110986000"/>
    <dbReference type="OMA" id="SIDWCEL"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071602">
        <property type="term" value="P:phytosphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022103256.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31364" checksum="5C20700F02E6806A" modified="2022-01-19" version="1">MAPIKDLEGVWGKPTSTLDWCEANYVVTPYIAEFWNTVSSLALIFIPILDLVYTKLTAPKRIHIERRNYMACLAFVSVGLGSWFFHMSLLYETQLLDEIPMIWGTCVLVYLFFENNSKPNSRNYVLVVFLVLYATLITGIYVLVINPVFHQVAFTLLVLAALVRGGYCFFYLKMECSPALFLLSVLLFVSGGVLWLLDNGLCMHLRHARSLVPTPLDVGLQLHAWWHVLAGLGAHCQFMFSYHSRLRYLKHRTTEWVGWFPLVTIIGKENGHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJ47</accession>
    <name>A0A8B7ZJ47_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110986035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986035</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103311.1">
        <property type="nucleotide sequence ID" value="XM_022247619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJ47"/>
    <dbReference type="GeneID" id="110986035"/>
    <dbReference type="KEGG" id="aplc:110986035"/>
    <dbReference type="OMA" id="HICTLAE"/>
    <dbReference type="OrthoDB" id="5950113at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034328081" evidence="1">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="34"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022103311.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="34517" checksum="4B33B9DB22AA2B89" modified="2022-01-19" version="1">MLSFFYLISISSLVTKAHNEPSCQGNARSCTTECPRNLNRDFNGIPNRVLLGHGYGNLTVASPVRCGRECLIEDRCFSFQYSEKDRQCELNEATASQFPLALIEKTGKNHFGPEQPTFAELITSWKGEAPLSLTDCWYQSRACASSDCQSAGQHLCLQWELQHAYKEGYPPTTPHGSWCADLGRLAVLTETGVTFHDLPLTTSAPALCCSVPVSYREPVLTEQKYDLADRAGQLSGCSDLAAHLCTLAELKEAYDHGYRCNCWYYFATPNRDASVKPGGCGAYYGSECYQGIIANTPRPANGRPAYCCPNRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJL6</accession>
    <name>A0A8B7ZJL6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Collagen alpha-2(I) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105828.1">
        <property type="nucleotide sequence ID" value="XM_022250136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJL6"/>
    <dbReference type="GeneID" id="110987416"/>
    <dbReference type="KEGG" id="aplc:110987416"/>
    <dbReference type="OMA" id="GRANIEC"/>
    <dbReference type="OrthoDB" id="10071882at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050938">
        <property type="entry name" value="Collagen_Structural_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456:SF6">
        <property type="entry name" value="COLLAGEN ALPHA-1(XXIII) CHAIN-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37456">
        <property type="entry name" value="SI:CH211-266K2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105828.1"/>
        </source>
    </evidence>
    <sequence length="1022" mass="94049" checksum="B50C38FC90D23245" modified="2022-01-19" version="1">MQSVASASLVGTSYHLHGCLCPVIVGLPGKPGLPGIPGQGIAGPKGESGQSGQAGPPGEKGDQGARGAAGLDGLPGLQGAKGETGPKGNHGAEGRRGPQGVTGPTGSHGATGSRGAQGPVGPKGEQGTPGTRGGRGATGSRGPQGPAGQKGEQGQIGPDGPKGNQGATGNTGPQGPVGPKGDHGATGGRGHQGAVGPKGERGQVGPEGPKGGQGPTGSTGPQGAAGTKGDRGHIGPGGPKGDQGATGSTGPQGATGPKGDRGHIGPGGHKGDQGATGSRGPPGAIGPKGNSGVTGPAGPKGNQGATGNRGFQGVAGPKGDHGPTGPGGPTGEKGAPGSRGPQGAVGPKGHKGLTGTAGPKGNQGSTGSTGPQGVTGPKGNHGQTGPEGPKGDQGATGSTGPQGPIGPKGDRGPSGPEGPKGDLGANGDRGPHGSTGPKGDCGPTGPRGPKGNQGATGSRGPQGGAGPKGDCGQIGPGGPKGDKGATGSRGPQGPSGLKGDRGQTGPAGPKGNQGATGNRGSQGAAGPKGDLGPTGPGGSKGNLGATGSRGPQGAAGPKGDRGSAGAEGPKGDHGATGSTGPRGVPGQKGDRGPTGLQGLKGDQGATGSRGLQGAAGQIGDRGPTGPGGPKGDRGTVGSRGPQGAIGPKGDHGPMGPGGPKGDRGTTGSRGPPGATGPKGNHGPIGLGGPKGNQGATGSRGPQGAAGPKGERGVTGPGGPKGNQGATGSRGPQGATGPKGNHGQIGPRGPKGDQGAIGSRGPHGATGPKGDRGLIGPGGPKGDQGEPGSRGIQGTAGPKGDRGLTGPGGPKGNQGVTGSRGPQGASGQRGDRGPTGPEGLKGNQGATGTRGPQGVAGQKGESGPNGAAGAKGNQGATGSRGPQGVAGQKGDSGPRGAAGAKGNQGATGSIGPQGVPGQKGDHGTTGLAGPRGDQGATGSRGPQGAPGPKGDRGPSGPGGPKGNTGATGSRGPQGVTGPKGYRGQTGSIGPRGYRGATGSRGAPGVNGQKGQKGEEGYSWCCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJR6</accession>
    <name>A0A8B7ZJR6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-binding cassette sub-family C member 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110986183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103541.1">
        <property type="nucleotide sequence ID" value="XM_022247849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJR6"/>
    <dbReference type="GeneID" id="110986183"/>
    <dbReference type="KEGG" id="aplc:110986183"/>
    <dbReference type="OMA" id="SAHIFCS"/>
    <dbReference type="OrthoDB" id="1726658at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103541.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="24554" checksum="F1A3AD39BF9F70F0" modified="2022-01-19" version="1">MKVAQVMTRQRKNILGCSDQRLKQSNELLQGIKLLKLYAWEFLYCNSIEDVRKKELAVLRKINFALVVTMLLTNGTPILVTLVAFGTYTPLTGLPLTPDMTFSSLALFNQLALPLFILPMSLSMVVSAIVSTKRLRKFLLAPEVEGKEPGEMGEGQKPSKDAVVKFRKPGEVAISTTFSKYITIGIQTDDDTEPINNGDVIIDSNGNAGKTGAVNGGFTAPDEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKQ6</accession>
    <name>A0A8B7ZKQ6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DnaJ homolog subfamily C member 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC110987222</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105462.1">
        <property type="nucleotide sequence ID" value="XM_022249770.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105464.1">
        <property type="nucleotide sequence ID" value="XM_022249772.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105465.1">
        <property type="nucleotide sequence ID" value="XM_022249773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKQ6"/>
    <dbReference type="GeneID" id="110987222"/>
    <dbReference type="KEGG" id="aplc:110987222"/>
    <dbReference type="CTD" id="134218"/>
    <dbReference type="OMA" id="RANHEES"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000046">
        <property type="entry name" value="dnaJ homolog subfamily C member 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="527"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="548"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022105462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022105465.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="66299" checksum="E73B1EBE0B9878CD" modified="2022-01-19" version="1">MPGQMRCHYEVLGVEMDAGDAELKKAYRRLALKWHPDKNPDNITECTEKFAVIQKAYDVLTDPQERAWYDKHREAILKGYGDDYEGGSVNLMQYFTASAYSGFGDDAKGFYTVYNEAFCKVAAEDLQFMTGDKGEEFEIPQFGTSDSPYEQVVHPFYAYWQSYSTSRSFVWKETYDTREAPNRRVARLMEKENKKLRDVAKKEWNEEVRALVSFVRKRDKRVQAYRKRLEEKNAERARLDAEKRKQERIEREKQFQEYAKQGAEVRAEMEASLREVEAALQEEFGDDSGSSGSHSVENCQEEDVLDDLFCIACNKDFKSEKAFSNHQNSKKHRDNVAFLKEQMEDEEGEMMDGKQEHSSQEDGAVDDADHEGLNQDSDNEEADGAKEPTELEKNKLSKKQKKKRKQQRVSQWSEPIHYAFHNNILEDLPSHIADRLKMTPPSGSPQAEVESDKTRDENGETRRAVDKGAGEGDPCERLNGIMEDAEETEKPAVKLKGKKAKEARRAAREKAASEEQQRVSSASDAPLLCNVCRNEFPTRNKLFNHIKSSGHALHVPSTDGTVDDSEKNSSKSKKKGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKT1</accession>
    <name>A0A8B7ZKT1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22 23 24" type="primary">LOC110986394</name>
    </gene>
    <organism evidence="20 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22 23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022103922.1">
        <property type="nucleotide sequence ID" value="XM_022248230.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103923.1">
        <property type="nucleotide sequence ID" value="XM_022248231.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103924.1">
        <property type="nucleotide sequence ID" value="XM_022248232.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103926.1">
        <property type="nucleotide sequence ID" value="XM_022248234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKT1"/>
    <dbReference type="GeneID" id="110986394"/>
    <dbReference type="KEGG" id="aplc:110986394"/>
    <dbReference type="OMA" id="VIRYDSC"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF16">
        <property type="entry name" value="ANTIVIRAL INNATE IMMUNE RESPONSE RECEPTOR RIG-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 21 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="168"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="527"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="19">
        <location>
            <begin position="708"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022103922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022103923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022103924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022103926.1"/>
        </source>
    </evidence>
    <sequence length="856" mass="97203" checksum="F8CC6C325F6DD981" modified="2022-01-19" version="1">MDAGETMATASELQHLHLQPEGRSVMSQRMMQDPRTSQGVVPYSPHGELVPHRSSPTVNALQVSTSNTQQLGFISGNNNMVLHAGTINIFQGSGATAAPPGRSQANLPLQNEDGRQQNRHTSNRAEMGCGVQIEEFPDEDSASLHAEQVECTPSPERPQLFLDQLELAEDAVQGKNTVLVAPTGSGKTHVAGYIIHDHFIAERPKPVWNRRALFLVTTVNLVEQQSNKLKFLLERDNFFSVVGIHGTSELSLKEEAKKRNVIVVTAQLLENALSYIPLDYFSLLVFDECHLCQKDHAYNTIMARYMDEKDRGNFNLPQIVGMTASLGTGKAKEQMDADNHAIQICANMDAQSISLVIRNRTALESRVNIPKEVKPIEVSCRKIDPFADKIKEIMKRIETMLNDSPYSAVRMSVNSEPIPSELGSQAFRQWCDRMKRCSQKIITLYEGVPYRILQACISQLKEYNAALLINKQVRTKDAFNYLANMMDKMNDRRRKFDDNDRELWLLYNREERILERIKDDPNNENPLLEKLCEIILAEYSIRPHSRAILFVKTIDTTQALQDWITETPELKFLNPGRIAGSRDMKSNQQNKVIEKFRNGEHKMLVATNLLEQGTDVPECNLVIRLDYVPSDFGHVQIKGRTRAKGGRSYLITLVDSNGAARDSANRQREIMMMEAAQHLKDMTQSSFKNHMESWQRSNRSERQIKEEKKRLALEANCDEVFVFCCSRCSKPAFLSRDVGRYKNCTYLVLDVDFSQHMEIRPHPKPKQLGANLTIIGKMFCKKCGHDWGSLTHIKQLYYPSAKISQFTLRSYNTGLAHTFKKWRDATFKVKDLVALPPDAAVEVAPDVLRKLEINLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZL27</accession>
    <name>A0A8B7ZL27_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987368</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105752.1">
        <property type="nucleotide sequence ID" value="XM_022250060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZL27"/>
    <dbReference type="GeneID" id="110987368"/>
    <dbReference type="KEGG" id="aplc:110987368"/>
    <dbReference type="OMA" id="EDHRINW"/>
    <dbReference type="OrthoDB" id="10056750at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10442">
        <property type="entry name" value="GIY-YIG_PLEs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF11">
        <property type="entry name" value="GIY-YIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="1">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105752.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="27324" checksum="895B7E0404FBDA79" modified="2022-01-19" version="1">MACESETDRTDLTPSQLHDLLTTCVNSTNFRERDKFFEQYLNSCSFHHPKIKSSVNRAHVRRVYNICDKEHLAKELHHISTAFQRNGYKPQQIKTQRILSKYDIKVFHTAPLKIRGMLTSHKDLQDPHHRPGVYKIPCQCCKEYIGETGRDLPTRLKEHQAHCRKGEYEKSGTVEHSHSEDHRINWDQANLITSIQHWYPKRIREALEILKHDIVPQDIGISISDIWQPLLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLT5</accession>
    <name>A0A8B7ZLT5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110987725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 25 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106419.1">
        <property type="nucleotide sequence ID" value="XM_022250727.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106420.1">
        <property type="nucleotide sequence ID" value="XM_022250728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLT5"/>
    <dbReference type="GeneID" id="110987725"/>
    <dbReference type="KEGG" id="aplc:110987725"/>
    <dbReference type="OMA" id="NDQQKIP"/>
    <dbReference type="OrthoDB" id="7690434at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.30">
        <property type="entry name" value="Mediator complex subunit 25, ACID domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021394">
        <property type="entry name" value="Med25_PTOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038196">
        <property type="entry name" value="Med25_PTOV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021419">
        <property type="entry name" value="Mediator_Med25_VWA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12433">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12433:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11232">
        <property type="entry name" value="Med25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11265">
        <property type="entry name" value="Med25_VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator of RNA polymerase II transcription subunit 25 von Willebrand factor type A" evidence="12">
        <location>
            <begin position="8"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med25 PTOV" evidence="11">
        <location>
            <begin position="672"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="221"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="372"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="530"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="849"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="981"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="981"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1010"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1031"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022106420.1"/>
        </source>
    </evidence>
    <sequence length="1119" mass="122205" checksum="BF0FB84F80E77428" modified="2022-01-19" version="1">MIVTADNASNVVFVIEGTAGMGAYFKELKTNYILPALIHFNGGPLGESDFSGDYGGPLYSLVIYNTVDCYPSPAVSCIAPTSNAWQLSNSMDNIQFIGGGGESGSLVAEGLGSAMQIFDDFKAKRHSSLANCTCQCILVCNLPPFSLPSMESGNYIGYTSEDLVTLMAERNIHLSIVSPRKLAILYDLFDKACGEGQKPIKDYTTDPRHLVLLSGFELTERSSGADTTKPLPPGSSPSHLQVASVAGATTSTSSASSAVPSSVTGTPAGSAMRSIGSSASQTNQSVSGRGAQRIGSPGFKVPSTNIPSSHSISSPATVNQGQGMSPQQPMNQFTSTQTQQQQQQQKYQQQQLQQQQQQQQFQQQQQQNQAAAQTYGGVGSRQQSLGNQPMSGQATSQMIQGGPQQQQQQQQQAQTQAAMSQLAKKTALQQLTPQHLKMLMQVRQQRQQQQQQQQQQQQQQQQQQQQTSTFNQPMAVVQPITAGGMPGMSQVQPNVTVTYTQAIPQPNPAGSVTAGQMVPSGAIQAVQDVMKHAAATQSQRWPRPGQQGQASSQRMPVKPNIPGIPGPTPSTPSTINTPLQQQQQQQQQQQQQGQSSLVPSTGVTGIQQQQAAPIGVVNPMLQQQQQQQQLVSSQQQQSMAMGSLPVDSMNVQQQQHQQQQQQMAGIQTGPVNTVVWRGQLEWHERPKMAGPEAKITRTHTCHVTVGPDSKLQVEQWPNKLIMQLIPQHLLQGLSPLLCNSQQVGFQFPEQNNDPEAMRALMKVMQSNFAGSVHFPTEVPCNIRILMLLYSQRKSMFVGFIPNDQAGFVNQFRLVLTKQKKNQGERTRGQMQPLGQGGQLQARQFAAAVNQQQQQQQQQQQQQVGLPTMPGSIPGSTNISTIGMSSVPVATASMGGMSTAGGSGGNGNAAMQGNAVAVAQQQQQQRAQQQRFLEMAKTRDLHMKKQQQLQLAQKIQQQQQQLQQQQQLQQQQQQQRLQQQQQQQQPVQPQQQQQRPQLPPPGQAVVPSGASPAQSQQLPTNNPQLRHLLMNQPPGTVQPGMQTQGQTQQQQLQWQQQQQQQQQQPGVSQQQQFRLQQPQQPIMMQQQAQVAQQQLSRQPAPAQPGIQGIGDELTLFDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNU4</accession>
    <name>A0A8B7ZNU4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ectopic P granules protein 5 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110987798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPG5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106570.1">
        <property type="nucleotide sequence ID" value="XM_022250878.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987798"/>
    <dbReference type="KEGG" id="aplc:110987798"/>
    <dbReference type="CTD" id="57724"/>
    <dbReference type="OrthoDB" id="75419at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058750">
        <property type="entry name" value="TPR_Epg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059030">
        <property type="entry name" value="TPR_Epg5_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF4">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26103">
        <property type="entry name" value="TPR_Epg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26573">
        <property type="entry name" value="TPR_Epg5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epg5-like TPR" evidence="6">
        <location>
            <begin position="1439"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="domain" description="Epg5-like central TPR repeats" evidence="5">
        <location>
            <begin position="1922"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1553"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2739"/>
            <end position="2764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022106570.1"/>
        </source>
    </evidence>
    <sequence length="2831" mass="320090" checksum="5CBCE8CBD8C3046F" modified="2022-01-19" version="1">MAEAVRPRKKHRKKKEVTSSKKQAEDRTDELLQDEDQDNLKNKEIPRSIQEVATFQDGETLRTSETDVVQDRDTGQGETSISMSQGVKEEAVDVEKECRSQDVESEEGRIDPSLKKVNPPESEDAASVDIASDDTAISKASVGEKYLDVATNGPETLSTVPERVHSKGRTASNEMPAGLEGKLQDDIKPVEFVKPEIQETEVVDSEVEAATGSQEICDKTGVNVLSQEKENMSAISEEAKDAEQVVMSSGNSVSKDTEEKGKATEEIEDSVGNQTLSETRDDAFEILEDEKVATVPSEAVIEDGAEKEALAKGLQEEGVEATAPPEQEVQSGVLTLRAIEVGVHNPLQDAASVQVQPESLESETSAPSGAQTIVKTEASHRPAERIASSETEEDSQSSLLMRQESIKTTKVIAMKEDQLEMYYHNSNLKQQEQFVELFIQMCCIEKHEFYELVTNYFKARNNMLAIRDDIENMQKEYTSLKEKLWTTSNNFILAKGICADNQMVKENHAYQLAQFNPDVHCDLERLMKYTRSNFHDTFALCSYTAQLSKLQIESYIHQLFLRNSWLLGVKEDAPVAADLCCDNPARHDQIKLLKQCISVLFAFQRRPVNDEEFLQTSRGWLSRMIATLLRLATRDDHLFVLGHILRCPAGVDQWAACYLQIVMPTHSSQEGAVDGRWPYSLGNPLLDHFLNMLAFFMRPVKYRQEYLTKMKKSLTPTPSEKPGPFNWTLLDEDGEEDEDTDNTLFNENDLVAIWAQYPFDKMFKHVLQITDDADGKASYSVDRVGSHHMMQLIAFASSLIRILHQGVQTYNRSRYRQFVKRIGRLIRHTVQQVSDHWLNYRSWRREVCHDSDDTRPSIQPHDLQHTVHNLQVEFDEFFFRATKCIMSAPRLGTWQFMTDMPYTSLSSTMMWRLLWSLHQDDINQLIIEPGQVNKKDNYRWQLSDPVKRDSFVHKLMDMPMSEVIYLLTTFANMTSARPAAEKMFINFVVDEIYELSYLRTHTREFCSKIGRELLSAIATTHPFVISTLLRQVQGSAKEVGMMALYLFRGLPFYLWHPSNDDITIMKEWLLGYEASKTENQLARLVLSKMNWGYNEQEDALFLNLSLHRNTAVLVVEAYLQVLTAKSPGASRLGTGPFSSQEQAFDVWAWDLVPKLRLHKHHQPRPVLLAPSDGAMDDGFGVLPNPSTNTKLYPLQKALQTNVAVGCFVNVAMTKTGHSIDSFITIGIPNMHTLIQAGCQQFCLPLLAMVVPMFLDEEHPDYLLTNEKFLTIVHRILQADHQNPRSSSTGSNTFPGDTTKLFAGMVLTQIQRSLAPCTSALVAEAVLEFWLKLLTMRSGWHFDPDICYILDVVLSAAICNKGGCSIAEEVLLKLYKFALRSTSGQDMKAEAKPQGFISSVLSFVTSGNPLPSLLEKQSLERPWLAYCILSAETRNLEQMGLLREVTMELCQDADMTPDMGLKRACQKLKLEYSMTLARLPIYRWAQLALETDIEHPLLPIIWQRFFMIYLQRVTAETGISQRASIGQRYFQSIANLTYLKRMKKRLRQTADFHYEASRKKPAPRPSPSSSSMGSTDQAEGGEEGARVDAIEEVEFEAGAEHHRHLVQLYQTFLLWLEEPLLHDASLYLPSLPSQYEAEKLSRIFNGDQDLWMEYANVDMANYHTTQLVNSWVKMSQPDSNTSGFSKSLTSEQQEKDSATSRILNRLTHYEDQQKPPSVVPIFAPVPDVPRELLVNNHAMLVFLQDDIKQLLYYSDTFSDRENRNVVLDCEFLELVPDLFTNKDVRYQIQIPCKSMFNPMHKCKGPAVVTVTHKSKKTNEIISRRLDENRAEFKQLSIESLAPPPSNVVVSAVHIENAITDLIHFSRARADSPAEFEAAKQTGVSLLYHLGNQMSESARHYPPTRQFFSSCIEILGQEYIRPYPEQAQPLMSAILANCNLAGLLAPNLAPNHCGDTFVQMYSDVVRIGISDKQDTAFMLLTKFDPVQWLNNCQPVIGVRSQFIEVVSEALTSCSLDMDNRSMMMFEIYRSHLRAILMYQFPEHYGDVLRLILKGSEEHCLHEDIWRDTLKSISCPVLSITSDTISTEQVKELIQTRPLLSLQQLQETVEWLTTYFSRQRNNNPQSGQFGLHSNWKQYHQPLVSFLGYIILNTIILEAHRVIEANVDVEQAVRRLWTLLSGLFYPWIVALEVPSPTNPNAKQLLPPWVEGDRVPASCMVSMFSYAIGCIQAQFQGYLDPPMVNALSLLWPFYHDTLAKKGLREDVLMTYHQHLVQLPWNQFYPGLASMELMVRVFEDRGPVCLAFLGNIFPRIPWRQISDSYCQGTDANTSNCFLSNLLSLLVIFLNEDNIMKAQGASMQHLIAQVKEFPWQLLDVSSYNCAATWQIDRCDPKLVLDQTKKQGDTSVRYASSSDGNTPISMSLMRGVARFNTPSSLDSSADASKRAAYVNLVIRMLCKCSSLDDCSKDWFPAPVQRLLNDIELLATAGGSTADRQQELISLLSTLLSLLNNCSPTRGAPDAILGALLVWFEASTSTALALPCITAACRTLASIKHSALVVEACIEAHFNTDMDLSPDPSRGWTNILQVLQVPELTHDEFLEECSKQGAILTLFAYIGQRSPQCQTLEEEYTLYTELINWCVKCKLRPANEAKVFLWWHKALQMTFHQIEFGSPHYTMSRSLNNLIPTMMTLGEDRSSAGLLGAIGFGRQSELSYRFRVVARCMAAFVSAQVLQNGMLRLAPNDPGALTRRRDTQPQSPTSPDAPKPSSIAYSALKHLDAAIDNKNYVGLSEHAQYARDVVLNPVKCLKDATHLLSQLTTVMFPEKHYLSVIQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQ53</accession>
    <name>A0A8B7ZQ53_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuromedin-U receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988386</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107524.1">
        <property type="nucleotide sequence ID" value="XM_022251832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQ53"/>
    <dbReference type="GeneID" id="110988386"/>
    <dbReference type="KEGG" id="aplc:110988386"/>
    <dbReference type="OMA" id="KACTANH"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="45"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107524.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30462" checksum="B49F8F239D1F8768" modified="2022-01-19" version="1">MVAAGLTGVFGNLLVCFVILRVKFLHTITNVLLVNLAVADMLQAYNLCLVTFEKYVAILHPLHYARRLTATRMKILTALIWVTSFISAVPFLFVHEPSDLPRKACTANHYQSKILPPVQVFSTLFGYALPITVMSVAYYKMQVTLKRQAKALNLQHARAAAYDLVIARQRLVNMLLIVLGALIILWTPAYVVYNLCPDGKDQALPSLCSSKGYELVENICKFLYYMNSVINPVIYGFKYKKFRQGLKVACCSCFSEHGNQNRVNNEIFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQV2</accession>
    <name>A0A8B7ZQV2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110988236</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107255.1">
        <property type="nucleotide sequence ID" value="XM_022251563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQV2"/>
    <dbReference type="GeneID" id="110988236"/>
    <dbReference type="KEGG" id="aplc:110988236"/>
    <dbReference type="OMA" id="ENMRSFM"/>
    <dbReference type="OrthoDB" id="368776at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46814:SF1">
        <property type="entry name" value="EGALITARIAN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="257"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107255.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="51593" checksum="5D2D8A0C0393819E" modified="2022-01-19" version="1">MAYFTEATPHTPAHFSKRESDLYDLEEVDAVLGAHSQVLEVCDKWAVVSVANCCRAIVFKGKICRGNVPHVCKMGDYLCPGYNVVVDVRRLKKGDAEARRQQCGWVVTKIVREEVTPLSPAYYRDHGNLFDFMDKGKRRGNSASLRPREIDQLGGWTGEAVHLIRSFLSSWNGISLAGLMDNLQSAKPIIKDALYCVKALRDFVESQPRFFTLTSQGFVYLQGGHRASCIENEIKSRLPRMDIGIFGDNAVIVHKPWHVGGIIKPVIRDEDTRVVALDTERASNSDCEYLSTVQIAIIDSVCPTPFIFDVLYWSNRDFKTSKLKHLLESERVLKVVHDCRGDSAVLERYGITLRNVFDTAVAHTTIMEQSNVGYTPPPNFTRLCEVFGRFTPQRNSKVVYQGNRNFWAKRPLTDNMIDHAASDVMGLATNVYENMRSFMNPAWKSRFDALCAKSLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQY8</accession>
    <name>A0A8B7ZQY8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Perlucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110988602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107988.1">
        <property type="nucleotide sequence ID" value="XM_022252296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQY8"/>
    <dbReference type="GeneID" id="110988602"/>
    <dbReference type="KEGG" id="aplc:110988602"/>
    <dbReference type="OMA" id="INCNDLR"/>
    <dbReference type="OrthoDB" id="538816at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050801">
        <property type="entry name" value="Ca-Dep_Lectins_ImmuneDev"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801:SF63">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22801">
        <property type="entry name" value="LITHOSTATHINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034404907" evidence="2">
        <location>
            <begin position="24"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022107988.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16468" checksum="ECAE68B696B00659" modified="2022-01-19" version="1">MNLPKHFTFGFVSLCLLITCMDGYDKCVASIRRSCPDTWSQWDGKCYKKLPVNLPWAEAREECIKMGSALVMPQSQEETEFIVNNKVVFFWINCNDLRVEGSWDCEDDRKLVQYTNRKAGESSNSSDQDCAWQQTSGAWNDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRU4</accession>
    <name>A0A8B7ZRU4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pseudouridylate synthase 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">LOC110988785</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uridine(13) in tRNA = pseudouridine(13) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42540"/>
            <dbReference type="Rhea" id="RHEA-COMP:10105"/>
            <dbReference type="Rhea" id="RHEA-COMP:10106"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with SIRT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108298.1">
        <property type="nucleotide sequence ID" value="XM_022252606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108299.1">
        <property type="nucleotide sequence ID" value="XM_022252607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108300.1">
        <property type="nucleotide sequence ID" value="XM_022252608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRU4"/>
    <dbReference type="GeneID" id="110988785"/>
    <dbReference type="KEGG" id="aplc:110988785"/>
    <dbReference type="OMA" id="CTSHDSG"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000002">
        <property type="entry name" value="Pseudouridylate synthase 7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.20:FF:000003">
        <property type="entry name" value="Pseudouridylate synthase 7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF31">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TRUD" evidence="15">
        <location>
            <begin position="500"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022108298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022108299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022108300.1"/>
        </source>
    </evidence>
    <sequence length="876" mass="97558" checksum="CD90BB33F0DB17DC" modified="2022-01-19" version="1">MAERLTCKRDHSEEFKVPEADETEPDHCGTSQASKRIRVVEECEGLPLADSTGILDKDVICTRWSVGEDNQDSLLPSTSQPDLQVEEKNLCTCSTSGNQELSGARTLSLESNATCSPTLTSDCQTVNQGDSNHGPSEAVTSTSALGDKSVSPWSGFDEGGTEMVKNRTTESDGGKPSFTDYLNKDCAATQQSPGSDGYSQYLRETSCLRDIAGDTDGQGRADGSASEVQTDAATPREPLQGLREVDVGIVEYISKHKGFHGVIKQRYQDFLVNEVDLEGKIVRLTDVSSPDPKPKVTINADEVLSAHDQQRLRELVETTDKKAFHCIEVYDYDKAKRKTVHELIRQDYGTLESATLDGDGKKVIKVTKVTRGGRKQRSSWDKNRADFCRFVMHKENMEVNDALTIIGKYLHVKHQSFGFSGTKDKRAITVQEVTAYRVEAERLSRLNGILRGIQLGNFRYVKDALTLGDHSGNHFVIVLRDINGSQEEIGEALTSMRDVGFINYFGMQRFGNSQVATHLVGRAVLHSNWQEAVDLILKPREGNSQDNRWRELWMATRDAQAVMDILPRHKTISVEMQLLKALKESQNSYCLSLQCIPRNIRLLYVHSYQSYVWNLMTTRRIQKYGLKVIPGDLVLNENKPDSDSEHLQPLVVDTSQLDAYSIQDVVLPLPGYAIQYPQNEVGDWYRELLHSDGLDIKSMRHQVKDFSLSGAYRKMVVKPDNVSWSVVPYSDVTIPLVQSDLDRLEGKELPAMKSDGHLRALRLEFTLSSSCYATMAIREVLKIDTSAAYQAGLNPAPLIESSPPLVSLANHLAIDMMMGLLAHKLPSQASEWSQATSLAVDSTGRSLPHKDIQKAQRSAQATAQSFLVNLIASMHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZS75</accession>
    <name>A0A8B7ZS75_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110988767</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108259.1">
        <property type="nucleotide sequence ID" value="XM_022252567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZS75"/>
    <dbReference type="GeneID" id="110988767"/>
    <dbReference type="KEGG" id="aplc:110988767"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108259.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35422" checksum="D54096936382173E" modified="2022-01-19" version="1">MYSAEDVHLYPAEKWMFFLEFFALTQFEQHTCTLELRLAEIDGLLDSSDHPFSSQDLLFENEQLCAHLVGNSELSQYDQAGAGWSEHPPANRENQPLMPDHGRVSRGSELGTSGVGSRPVAGASPGSVKIDSDEESLPSFTDADLDPEWSLDEPPSKRLRTAAPEDCYNIMSVKEKHIKKFQAHTYDYNIQFQNMEECAQYDPTSKSGGLFTEYVSYFLKIKVENSGIPKWCKNEADIEKFIQEYEEKEGIVLKHVSSATRREGVCKPNLNGVTLDDLGDAETVFEINVQAYSLVLREDGDSEEVETDDQGRQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVM8</accession>
    <name>A0A8B7ZVM8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc finger matrin-type protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110989047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108830.1">
        <property type="nucleotide sequence ID" value="XM_022253138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVM8"/>
    <dbReference type="GeneID" id="110989047"/>
    <dbReference type="KEGG" id="aplc:110989047"/>
    <dbReference type="CTD" id="55954"/>
    <dbReference type="OMA" id="HNCRFSH"/>
    <dbReference type="OrthoDB" id="2417221at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465">
        <property type="entry name" value="NUCLEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16465:SF0">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022108830.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22175" checksum="8485A326E94E6F56" modified="2022-01-19" version="1">MGRRYYCDYCDKSFADNAQNRKKHVQGVQHQSRMKIHYLAYKEPEDILAEESAKRPCQRFHQSGECMFGHNCRFSHLTPQRRQELLAEIEKRKQQDFEKTRQKEQAERGRLQDNPTVEDWLEKRSRKRPRKTDAETRQETEGGMPKDASAEDSVMAFSLPPALQGIPNLPPSLIPPSVECVMRGKDVEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWK5</accession>
    <name>A0A8B7ZWK5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General transcription factor 3C polypeptide 5-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110988568</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107916.1">
        <property type="nucleotide sequence ID" value="XM_022252224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWK5"/>
    <dbReference type="GeneID" id="110988568"/>
    <dbReference type="KEGG" id="aplc:110988568"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.160:FF:000002">
        <property type="entry name" value="Transcription factor IIIC, subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="24"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="185"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="481"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="512"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022107916.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="65641" checksum="803FD9BEE2366769" modified="2022-01-19" version="1">MADNLHEENSSALADNPQKLPHLVCVEFPARVQNVDKMLKTLGGEEAVSKTLSADSAKKLQMKFRPDDPFCRSLYASKQPATSILLRVKKRYKKQAGSGSVEMESDSQGDDLEDEGKKVVQEQAGYQTELVGVIDNVYQFKGMCDFQYLPMQRNEETGRMESLIEKVIPTKPEDASFLKQDVPLFMLPPVFSRTDQASTHHYHPDVVPSMESLSYMVGKRLDKNIVGSGRARRPHNTYLVSFEQDSVPMAPHPDAMLVFEKGKERDNSVGLLRDELVQIFTKRPVWSRGALRHNCTLTDRQLSVLLPSVSYYFCNGPWRATWVRLGYDPRTARDGLKYQILDFRIRKSLYRNKLVMPADDQDRFRNTSTRRSMPASFQKPDKKLSTYVRPPKSKVLQRENRKALEKEAYFIFREGLVPAYNQMFYQLCDIDDEGVQAMIRAKSNSAGIRQPVRYLEQEVLDQMRSAMNEILKRTLEQEVLKRGVTTEGDEDTSSRSSTSQAENVGIEGPDTCMDDDEEEDIEDSPEDIDDNDNEDGPEDVDDNEDMEEDGLNMEEEDESENEMATELLEFFSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXK7</accession>
    <name>A0A8B7ZXK7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cell cycle checkpoint control protein RAD9A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">DNA repair exonuclease rad9 homolog A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110989620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'-&gt;5' double stranded DNA exonuclease activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109832.1">
        <property type="nucleotide sequence ID" value="XM_022254140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXK7"/>
    <dbReference type="GeneID" id="110989620"/>
    <dbReference type="KEGG" id="aplc:110989620"/>
    <dbReference type="OMA" id="HTTRDEY"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000005">
        <property type="entry name" value="Cell cycle checkpoint control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026584">
        <property type="entry name" value="Rad9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009303">
        <property type="entry name" value="Cell_cycle_RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="278"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022109832.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="54975" checksum="CA613889537494BC" modified="2022-01-19" version="1">MKCMIPGSNIKVFGRSIHCLSKIGEDLYIEPLDHGLALRTVNSSRSAYACFLFAPSFFLSYINESWNEQKASQQEEDSFRCRITMKSCLSVFKSLYTLEKTVDKCQIYVDLKDCRLVFLLHCKHGIVKTHNLTYQETETLQAVFSKDLCPNHIIANSKALIEVVSGFQTSQEEITLNVNPQQVSFKNYIEDEPDPNKVVHSEMFLSPSEFDDYTIGVDAEVTFCLKELRAVLSFADASGLLVSLHFESTGKPIVFSMESDQTIEATFVLATLADLPSSQNSSQRRVTSASQHSAVNHSSHTHRETRTTDTHTQNEVNFRDDLNSKKRSRHCIQSESLRMEDAEPEFELGNINRISSRSSSCAVIPLHSHIRQAHKHQARPALFPELSSDPADSEETTQVPRPNRTLLANFEECEVGEDGHDSQQTHMASVEQAVDKASVSDSEDLDFVPGTPPSKKFKSMFFGASQQASQPVEPAQNSTVVLCEDTDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY57</accession>
    <name>A0A8B7ZY57_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High mobility group protein HMGI-C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110989749</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022110027.1">
        <property type="nucleotide sequence ID" value="XM_022254335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY57"/>
    <dbReference type="GeneID" id="110989749"/>
    <dbReference type="KEGG" id="aplc:110989749"/>
    <dbReference type="OMA" id="KMISPWL"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022110027.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12110" checksum="BA9DC49C77EC3CA9" modified="2022-01-19" version="1">MDDSSNDHGAATGDAVTQAPPKRGRGRPRKNPAPSTEAPVIKPKEAKSKSTKENGQATKETKKAKAPKTKAQPPKKEAPPEKKKRGRKPKQKQRSSEEEAETPNDDASTEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY73</accession>
    <name>A0A8B7ZY73_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Octopamine receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110988887</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108511.1">
        <property type="nucleotide sequence ID" value="XM_022252819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY73"/>
    <dbReference type="GeneID" id="110988887"/>
    <dbReference type="KEGG" id="aplc:110988887"/>
    <dbReference type="OMA" id="GGLWFFA"/>
    <dbReference type="OrthoDB" id="10026919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="65"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022108511.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="52602" checksum="02FEF9A6D2E00820" modified="2022-01-19" version="1">MNDTDNTTAVTDYSDYVTSPSSFMDYSNDTTLNDTSTNTTTDSSLALNAGLGSLSCVITLCAILANSLMVALFARFPGLRSPGPAFLLLNMTVANLIVAVTALIPNTVAFFVNGWLLGDLVCQLSAYLSCFAFHLTVHTMGVAFFERYLKVCRPLKHAEIFTTVVTVILVGGLWFFAMVLALFPLVGWGEYAYLPLQRQCWISPGGWQGHLSHMGFTLVLTLLLPVLTSLVCLVTVIRFAAKKRKVGALDVLGDQGKTGIQETYGRKMKRKERELKQTIRERKLKKVKKKKGKKKKKKEKKDDQSSSSSSSSSSSSSSSSSSSSSSDEDERPSYKKYKEAKNKQKAERYRANEAALVRTLTWILLLVLLTWVPYMVAKCLQTLEPTSGIIPPDEFLIVAAFLTYSTHAIMPIILLLDYRKYRRAVVALFSRKKMEVGKDHAQNLDLDLEQGEMDSGIELTNAGNLAEGSKTSVKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZI2</accession>
    <name>A0A8B7ZZI2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flotillin-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110990260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110844.1">
        <property type="nucleotide sequence ID" value="XM_022255152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZI2"/>
    <dbReference type="GeneID" id="110990260"/>
    <dbReference type="KEGG" id="aplc:110990260"/>
    <dbReference type="OMA" id="AFQIQDI"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901890">
        <property type="term" value="P:positive regulation of cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002090">
        <property type="term" value="P:regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031905">
        <property type="entry name" value="Flotillin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF46">
        <property type="entry name" value="FLOTILLIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15975">
        <property type="entry name" value="Flot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="86"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="244"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022110844.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47493" checksum="FA6B9DF4FA1F27ED" modified="2022-01-19" version="1">MVFFEVCGPNEAMVVSGCCHSKPLLVSGGRTFVWPCIQQVQKLSLNTMTLKIDTANVYTRLGVPVSVTGIAQVKVQGQNKDMLLQACQQFLGKTEQEVEQVAMETLEGHQRAIMGTMTVEEIYKDRKKFAKNVFEVASSDLVNMGISVVSYTLKDVRDDNGYLKALGMARTAEVHRDARIGEAEAKRDSGIKEARAEEERMAARYANDIEIAKAKRDFELKKAAYDMEVQTKKADSELAYDLQAAKTKQRIREEEMQIRVVERTQQIQVQEQEIARREKELKAQIKQPAEAEKYRLETLADANMKRVVMEAEATAEAVKLKGEAEAFAIEEKARAEAEQMAKKADAWKDYQDAAMVDMVLETLPKIAAEVAAPLAQVNKVTMVSSGKGDVGATKLTGEVMDIMNRVPQLVEKMTGVNITEAISATRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZP4</accession>
    <name>A0A8B7ZZP4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110989182</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109056.1">
        <property type="nucleotide sequence ID" value="XM_022253364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZP4"/>
    <dbReference type="GeneID" id="110989182"/>
    <dbReference type="KEGG" id="aplc:110989182"/>
    <dbReference type="OMA" id="AARNQFM"/>
    <dbReference type="OrthoDB" id="10072605at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="15">
        <location>
            <begin position="203"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="636"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="720"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="878"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="654"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022109056.1"/>
        </source>
    </evidence>
    <sequence length="905" mass="100190" checksum="94EE419291F121C8" modified="2022-01-19" version="1">MYEMTITLGPTAACVGARDSVTCVNECDVSSLPQVCLLKMDEDEEVLLETSPLSQYLREACPDEDFETAPVVGKKTTRGLMSKDCNEEVSFIHQPGLKGSVHQAFQWMFPPVSTCILNVDKEFLPQYSSLALDSQLLVDADQQIVQAYRLKKSQDSTHLSPAHLQPVVRKHAHVGCTLAVLCAALAVLFQDVLDRNFSYTCAILCFALLLSCAAYVFHSARTCWISNSQRSLHRNSMKCFEQCLKLLNQQGVLLKKSIRYIQEVEVISRGFTMVSPYTPVVRLERAVTTRPNRQCVALREVCFSVARAQFSTLRDATLEVMEELPLVAEIDHVSNYLAMVRLEETTPWINVMTDDTENGYNSLEELTGFFSLAALKTMNSLFLEQRSEFIRRLVLCTCSDARLEPKTTANFLNSWSGIVRKVSASCETALGKLQRSYDCHRQRPDRNRYQTPGERPSQGDDEMQRVGCAVRSLRLHLEATLNRVITVEEALEGVDRQLAGGEDDVGALMCEMLDSVRRELTASQDCLQEAASSLEKMSHKDLSSKQHKQDGQGGIVQSSVSAEGREPILLFPMRDSEIEFDDQIFEAYTDTDPGQRDDEGWGEEISDAEKMRRRREAEETKRMLQELRSVLTVRKAQRERMKSERIKTYKKTSGRVSPSDSSKTDGGTEQDQCTGRGMPEGDIGTVDTPSENAGGILASNKALNASEDSSDFRMLRCINAENPGPRENAGGRTSGSSRDFGPNSPLHDDADARKSSIGATDDVGSVGLSSTDAGEMEVARFVTAGPPCSTSESELVHNGEFNESYWQEGTSVGDSHMTKLAGKSSVMAYDMDQSETNLPGNEPLQDSATVKSPFNLTEGQTQFGMSFLPSLAAEAAKRSRQCRQEEETFIGSDDDSEASEVGVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A224</accession>
    <name>A0A8B8A224_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110990638</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110990638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111412.1">
        <property type="nucleotide sequence ID" value="XM_022255720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A224"/>
    <dbReference type="GeneID" id="110990638"/>
    <dbReference type="KEGG" id="aplc:110990638"/>
    <dbReference type="OrthoDB" id="16287at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="27"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022111412.1"/>
        </source>
    </evidence>
    <sequence length="674" mass="76542" checksum="98899C3C8D060D05" modified="2022-01-19" version="1">MARQLRTRRISPLQAAELWCDLSTDQKGFEKRLVNRCIGYGLFATKAFSKGSFLLEYRGVLTSPEENDVNDMDYVYHFFHKGAAYRIDASQQDSCLARWINDDRRHPNCTMKKMVFETSKEPHLCLFALEDIDINTELRYDYGTRNLPWRQSSSAASAPPSSSAAPAPQSSSTAPAPHCEALLPAVGEWQVQPSRSRKNNTDESSDKYFTDDNGSDFVPSSEESEIVAESSDEKEQAHLLWFIGPRMMSARRIIFLVNIAMVIMLNQISGSTNVVKSQFRMDQMSHVPKKGKEPCIQTLHEGRRNNPKLLPLTEDVVTLSRFLKDEVRSREEVLRNSSEPREIQNAWIRLAEIVLTQVIVFNHKRPGEIAKMTLSDYGKCTNGEVGIIDGALTTWEKQLCRVLWRVEIVGKRSRTVAVLLTDLMKHALDTLISKRTEAGIDENNMYLFAARSREGHLRGPDTVREHAGMCGAKKPAYLRVTRLRKHIATVSQIMNLQENELDLLAGFLGHDLRTHRQFYRLPESTLQVAKISKVLLKMEKGDIRGLPGKSLEDIQLNPSEEYNTDEESDIESDLSDADQPEDPPVCPQSRQNGASNQQRSEGQKKRRAWTSREKAAVVQHLRGYLQSRRVPGKAAIMVLLKAEPTTFANRSWRNVKDFVRNHISKKDPFGFLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A278</accession>
    <name>A0A8B8A278_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110990396</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111080.1">
        <property type="nucleotide sequence ID" value="XM_022255388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A278"/>
    <dbReference type="GeneID" id="110990396"/>
    <dbReference type="KEGG" id="aplc:110990396"/>
    <dbReference type="CTD" id="6392"/>
    <dbReference type="OMA" id="VYDYARP"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022111080.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16508" checksum="468DD39444A8B59A" modified="2022-01-19" version="1">MAALRLFRSRALLVSPQVVTSSFLKSDNARTPYGPTMVHTSPPNQSTGQSNVMASTRWKFEHMVTLAMTAAVPTAFITQHPLLDYVLAGCLTLHGHWGMESIFLDYMPGKTLPKVANSCLFGVSVLTFAGLCYFNYNDVGITKAIMMLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A6C3</accession>
    <name>A0A8B8A6C3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Torsin-1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111531.1">
        <property type="nucleotide sequence ID" value="XM_022255839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A6C3"/>
    <dbReference type="GeneID" id="110990743"/>
    <dbReference type="KEGG" id="aplc:110990743"/>
    <dbReference type="OrthoDB" id="19623at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002370">
        <property type="entry name" value="Torsin family 3, member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF2">
        <property type="entry name" value="LD13476P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111531.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37978" checksum="D3BB1BF0EF03A9D1" modified="2022-01-19" version="1">MICRDVNYTRDDYFVMFVRCMGARTWFTMALAAILSSSLQSSSSTRAQTLIRLILTCAVCIHIARAFSFNDVAKYVDKPWCLMECCQVDFGWIIHTNTSGLQEALSMQVFGQHLVTDHVVGAVDGHLTNKDPNKPLVLSFHGSTGTGKNYVARIIAETIYKEGMNSRYVHHFSANKHFPHKRKLKQYQNYLRRYVKAAVAWCPFRLFIFDEVEDMPEGLLDSIRTFLDYNIHIDGVDFRKTIFIFLSNIAALEISQKTADHLLAGRSRTEITLKEMEKVIEVTAIDASGECHSRKAGTYSRDYIECDVIGLLNRERLLPTWGMGFFGVEQSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIG4</accession>
    <name>A0A8B7XIG4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA-binding protein 41-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110973794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080588.1">
        <property type="nucleotide sequence ID" value="XM_022224896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIG4"/>
    <dbReference type="GeneID" id="110973794"/>
    <dbReference type="KEGG" id="aplc:110973794"/>
    <dbReference type="OMA" id="ELMALFC"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030626">
        <property type="term" value="F:U12 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045164">
        <property type="entry name" value="RBM41/RNPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16105">
        <property type="entry name" value="RNA-BINDING REGION-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="391"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022080588.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="51834" checksum="5E5AE63432951436" modified="2022-01-19" version="1">MEDDPYEDESCPDFEPAVQSTGPSEAVLCVQRMLGEQLDTNISLEQQASKSRSFTQAAATFRPFVEQASGQLSLEEFQALEREHEGLEKLRACGLSDEEIALKLEHEGRHLSNLLYPHKRHRSIADPVARLKRLKEVEGKIQRKKASLSSSQDAASSDNKETDNDLQGSAISSPKHPSLLSKKFVHPDDPINHLDTITAGLFGESSQGKQVRNVSQRSGNAVSLMAEPSGGCSPGCQGNGPHAAKKEWQANECSSKEKSVDGYQDGLRVKCALETCGRDSCRESITKRALHISKDGNLTNTPEQEIALEGCPEEEISNSAIGSQETGKISRQISGVQGKCMDEQDEDKKPRRLACIVSPLSREDLLHHHLSQDDIRRMERFANYSPGEPSKVLYLKNLSTKVTEADLASLFISFQHPDKPKIIFKLLKGRMKGQAFVTFADTEMAVEAMAHANGYPLKGKPVIIQFGKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIY1</accession>
    <name>A0A8B7XIY1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCR4-NOT transcription complex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cell differentiation protein RQCD1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110973517</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080087.1">
        <property type="nucleotide sequence ID" value="XM_022224395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIY1"/>
    <dbReference type="GeneID" id="110973517"/>
    <dbReference type="KEGG" id="aplc:110973517"/>
    <dbReference type="OMA" id="EKVYTWI"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000037">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022080087.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="34964" checksum="548C54B2825B2A16" modified="2022-01-19" version="1">MHALSIQQRLTSSSIPPANQSTVAALAQVEREKIFQWIIELASPETRENALLELSKKREIVQDLAPMLWNSFGTVAALLQEIVNIYPFINPPALTAHQSNRVCNALALLQCVASHPETRSAFLQAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEPEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDETGLSYICQTYERFSHVAMILCKMVMTLAKEPSARLLKHVVRCYLRLSDNARAREALRQCLPDQLKDNTFVPVLKDDTSTKRWLAQLIKNLTDTGVPDPRGIPLPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJ05</accession>
    <name>A0A8B7XJ05_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Low-density lipoprotein receptor-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110973406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079920.1">
        <property type="nucleotide sequence ID" value="XM_022224228.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973406"/>
    <dbReference type="KEGG" id="aplc:110973406"/>
    <dbReference type="OMA" id="YQGACTS"/>
    <dbReference type="OrthoDB" id="10047962at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF62">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="32"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034266618" evidence="10">
        <location>
            <begin position="33"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1346"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1384"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1348"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1392"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
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    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="203"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="215"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="252"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="277"/>
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        </location>
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    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="289"/>
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    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="308"/>
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    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="315"/>
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    <feature type="disulfide bond" evidence="8">
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            <begin position="327"/>
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        </location>
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    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="362"/>
            <end position="377"/>
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    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="436"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="457"/>
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    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="464"/>
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        <location>
            <begin position="476"/>
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        <location>
            <begin position="496"/>
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        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="532"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="539"/>
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        </location>
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    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="551"/>
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        </location>
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    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="571"/>
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        </location>
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        <location>
            <begin position="578"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="590"/>
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        </location>
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            <begin position="610"/>
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        <location>
            <begin position="629"/>
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        <location>
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            <begin position="1302"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKS5</accession>
    <name>A0A8B7XKS5_ACAPL</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110974224</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110974224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081408.1">
        <property type="nucleotide sequence ID" value="XM_022225716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKS5"/>
    <dbReference type="GeneID" id="110974224"/>
    <dbReference type="KEGG" id="aplc:110974224"/>
    <dbReference type="OMA" id="RETTHYR"/>
    <dbReference type="OrthoDB" id="10401609at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022081408.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="17878" checksum="513C3E181F88621F" modified="2022-01-19" version="1">MAFKTKYKEKRRMISGTMLHYRKSSDQDVTESAISDRNPALFPRDYLKPLLPQDFPLAVRRSQVLWDAQNELLQRATEATRRMEVAKAKFYAWPDTDGDRKRTAGPCQLLRNYRNWEKVTDEGALFSQRETTHYRTRRVHFNKEIKIIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKU3</accession>
    <name>A0A8B7XKU3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cilia- and flagella-associated protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110973873</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CFAP43 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080756.1">
        <property type="nucleotide sequence ID" value="XM_022225064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKU3"/>
    <dbReference type="GeneID" id="110973873"/>
    <dbReference type="KEGG" id="aplc:110973873"/>
    <dbReference type="CTD" id="80217"/>
    <dbReference type="OMA" id="FNCQAIT"/>
    <dbReference type="OrthoDB" id="535167at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25828">
        <property type="entry name" value="CC_Cfap43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="546"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="915"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="755"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1006"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="560"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022080756.1"/>
        </source>
    </evidence>
    <sequence length="1271" mass="145638" checksum="6CEB87FC21EB9D59" modified="2022-01-19" version="1">MEDNKLLSSLSLNKPASCLASCPSSHCIAVGTLSGHVFFLDLSNVDNPRIIQRLHIHQTPVQQLVYDEEGRYLFTGADDGHVFVVDARPSSSFKILGQTPIEGLVVAISTNTSEKHGPVKVLVTSNTTPDVTQGANKCCQFDLPNDLPQDIDNFLASAKCDFKEDSIQKMNLNFSVPCIGAALTTGNVFYTIAYDTKQLHKLVLPEEAPKKANNKASYLQPQGEFPGHDLPGGSLILSHHQKWLASCSPDGHVLVRGVGALDRPIVVQAHSFCTGGVKQVCLSTDAQSVLTCGAQDGILSCYTWNYSSTGRSKATSAIEAARSHNAMLHAIRKREDEVLSAMPDWNETMSTPMSRSVSDIQGPKKTGIELAIEKDEIYVTPTPTLASDPTWMDVKEMEALREEDNQYSELKSALRSDIRELRRTIQSMMKDNETLPDIEQLGHDEFNLDSEEQQRLQEEGEAKVQEMRTNMEFEDLAKTYLREVIKNECWDSMLVKGRSIKAFHMNLEVGNYPMRDRTKKEKEELTFVTKMRQIEMAEMAARKEIIEVQPKGNNAKPSDAEDADDESEEGDGTEQPSTIGSLGAQYGGANDLFYSQFELHTRQQKRNQIILLQDAIYRIKMAFNKDFDEVYRAKEQEITRISDRNQRILKIMEDLISTEEVWKPQMDTDEKPEKLLTVEDSEVKVEKFITPEQRKKMEEEAAEEAERKLREKGDNARERALDMMMGGVLEIKKEDELKKDIPIPTFMAKAQEEWSEDEQKAHKEYERKVKELNEEREKYRKTLEAELKKIQTIIADTTSNFDDRLTDLFHRKIKTEMVIYQEELKILRLNRELLIEEELDAQEEELNRRLETKKALKAETVQAVMKAKRMVDSYRDTYDIRVAEDKVLEKNFRKEFPDVHAVLVDQLFKLYRRRPRGQRRDHKGSISETPGGPSNPYGERPLSARQSNTTVVLMKGLDELDHESHCPEGIEPHIWTRLCNLRRTKVLSEQEVKVQALTLADMNAFLQHRQEEDDKLKSEIEETNEALNRLRDERFQFNCNLDVQFLLKQGQVEVDSGPFIHDFSDSILIHRGVVEDLNGSIRQLGEQKIAAMTESKDFRKGIHILEWEHKKMVMQIEDLLNKARTIQMLKVSRDLQTFLHSEDHEARRQQEISTLESTLENQRSHHEKAVEERKKTLRGLRHTIWSKEKNNAGLDDDLEEMNVSVAERKHINEVNAAMRNVGGSAQRMKDIVQRRKLVDLAKAQAQEVAVLRAEVERLRMRTFPALVQVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMW6</accession>
    <name>A0A8B7XMW6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ficolin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081507.1">
        <property type="nucleotide sequence ID" value="XM_022225815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMW6"/>
    <dbReference type="GeneID" id="110974279"/>
    <dbReference type="KEGG" id="aplc:110974279"/>
    <dbReference type="OMA" id="PSINGHI"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF444">
        <property type="entry name" value="PROTEIN SCABROUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081507.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21928" checksum="62CFBCBA8909A27F" modified="2022-01-19" version="1">MQVYCSMESGRGYIVLQRRVDGSISFHRNWQEYADGFGDLTREFWLGNEKLRTLTEPASESWELVVTLTSFDNQEARAHYGGFSITGATYDLDASDFDSGAGQAGDSLTALHLRSFTTSNQDNDNSGGLNCGQVFRSGWWFKKCNRVDSNLNGVYHSSPVVDDYQGIQWVSWKGRRYSLKGCEMKMRRNVVATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN21</accession>
    <name>A0A8B7XN21_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Epithelial splicing regulatory protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974726</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ESRP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082223.1">
        <property type="nucleotide sequence ID" value="XM_022226531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN21"/>
    <dbReference type="GeneID" id="110974726"/>
    <dbReference type="KEGG" id="aplc:110974726"/>
    <dbReference type="OMA" id="FTLTFHV"/>
    <dbReference type="OrthoDB" id="431068at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="329"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082223.1"/>
        </source>
    </evidence>
    <sequence length="711" mass="79918" checksum="252FB6D656CCBA3A" modified="2022-01-19" version="1">MTMANAHNYLVIVFCTTAGQRGALLGTDETDLVLLVWGVIDVETNKLVGFIKQSFVRPDSDNVEVSEDLCKALGVQREVFKGAAKMEKVLQQFEEFLYRELNLSQGNTFCLLTDGQLHIRQCLHPQALNKNVELPDFFYSFFDLRKEFQKFHAGATTITTVKDMADYLKIDTGNYNFTETGLDECRVMASIVQRLIHEGHRFTNPDQIRRKYEPGTFDKTDTVPDNTVVKARGLPWQASDRDVFRFFKGLNIAKGGVALCLNHYGRRNGEVMVHFESSQHRDMALQRHRHNLGNRYVEVFKGTGDEFIKVAAGTSRDAALFLSRDDGHIIVRMRGLPFTATAREVVDFFGPTIPVSGGEEGILFVKQRNGKMTGDAFVLFSTEEVANKALEKHKDYLKNRYIEIFRSTTAEVQQVLSRLHSEPLVPEGPPPANVMVPNIIPPPPAHLVPQPHPAAFVPQQLITCGMIRDCIRMRGLPFKATIEDIMRFLGETANYIRPHGVHMVFTMQGNPTGEAFIQMMSAEKALLAAQLCHRKYMGERYVEVFQCSGDEMNLALMSGARGKAVQPQAVQSAIAPTTPPFPYQQQLQSPNGGMIPTTTPMPAIQTRQQATHSYIQQPLYYFPSPPVSPTTSQLYHHPHASNAVIRLRGLHVGATPQEVANFFQGYGVPAENVQFQYNGDVLVPFYSQELAMKALHDKQRQYTGKMELFMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPL2</accession>
    <name>A0A8B7XPL2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: death domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110974627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082112.1">
        <property type="nucleotide sequence ID" value="XM_022226420.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974627"/>
    <dbReference type="KEGG" id="aplc:110974627"/>
    <dbReference type="CTD" id="401124"/>
    <dbReference type="OMA" id="RIFHYIE"/>
    <dbReference type="OrthoDB" id="6118651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28336">
        <property type="entry name" value="BA1-643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28336:SF4">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="1048"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="972"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022082112.1"/>
        </source>
    </evidence>
    <sequence length="1155" mass="128272" checksum="867A7EF3B36E8CA0" modified="2022-01-19" version="1">MADVTEAKSSRCRHTHDDGDKSSSRRTDPVKGTNTPSQANSVGSIDSKKGMDSQVSLKHSHGDRRSSVASKVASRDSVSEASVPENLSTDEVSERASLEASVSRRSTSGNLQEQASSVTYSTDSDISQSPSGLRGAADNRSARGDSLYSSRVASFSEVSDKCSIKTTVRHDDTERGDIERGSRTFLEQDASEGYEPSENEAYSVDLENRDDEVTQGDTNMAAVFSSFIQAIREETQRLEDIENLRKFESSHVRGMLGELTETLRDTEDQSLRLFEGIEAIRDAAQGLKKTLEARMNRSTNAEAEAMTEGQETTDNKKAHSRAVAAVSAAKALLAEVALDVTAATRMAAEAESAAAEAAVAAENAAEEIEEIEEKLGEAETGAGLETDEVEEEDITGDEDGEKQEDDDEDNDDARQSEEDASSRPEEDANAVPDEELQAKREDEYINGDHRDKEEDVFEEDTEGTDERKVETPKPPESPKRRKSIKDNVMEWPYHILNLPDHDFTDDEIGCILRYKEEYFTTSTPDFRCVVNNHMSVDAVGDSEEMVSHVVTVEHVEDTSSNELEAPIAVAVPYGVSTRMMNTREFAVKFKGGNEDEWKVIPMLTTDSSFAEHKGPFAEVRTTHLGSFAVIARLIKDRQTITKKGGVVKSSSDHRMNVTYPPGMCSLMSVTLQVQPAEQAVSELRERMRHCSDLITASPIITLSHSSDKPFEKPVTVTIPCPPNPLKLPVPGGNASTTQHKLAERQVPLSPDGAVIIRGTKSSIFGGDPAEDTLHLMYRQSNWSYWNEFENAQFKQVRKDLVSMELDKPVDKLLILRMTSDGRYPAKNVAQTFEKALQIKYASIILHHRVDDPQRVVVQCVPARQLDSALRRLSQEGYEGPPEPSADVAMTEGQEITMKFSGNIKIVGRDQITFTFHSQRRNLVEFLVEETNKFGNHSSDEYRGVAXFYGTPRITLTDMEDPEEVLLREAEAKAAEKENKRSGTSMLTKAEKKKPEGVDGAGRDYQSLRKVEPDLICKLSVLLPKAEPEPPLPPSRYRATAIDAGGAASNTNLRWLSSELGNEWESLATVLGIKRSRLQSIKRNNPIKVEHQVFDMLVTWRSMLPRAYDKERKLCRALVRCGRYDLAEELKERDVANAETDTAHNNNVNLLDMDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPT8</accession>
    <name>A0A8B7XPT8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110974704</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082192.1">
        <property type="nucleotide sequence ID" value="XM_022226500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XPT8"/>
    <dbReference type="GeneID" id="110974704"/>
    <dbReference type="KEGG" id="aplc:110974704"/>
    <dbReference type="CTD" id="10419"/>
    <dbReference type="OMA" id="IKYAWYE"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044020">
        <property type="term" value="F:histone H4R3 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000003">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000008">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000029">
        <property type="entry name" value="Protein arginine N-methyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1 8 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="14">
        <location>
            <begin position="30"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="13">
        <location>
            <begin position="300"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="15">
        <location>
            <begin position="470"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="335"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="421"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="11">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022082192.1"/>
        </source>
    </evidence>
    <sequence length="638" mass="72023" checksum="89065C8F6156636F" modified="2022-01-19" version="1">MAGQQHVSCGRDLHCVPDISSSTQLASVAGFDFAAMPLVHPRFKREFLEGKAKDRQGAFARSDLFLSSQDWSSLVVGKLSPWLQLDSDDEITRKNSQAALKQELAYAAHLSVPAVLVPLSNSKCANLGRCLLSHMQGHSNHQVWIQVPMVAPSRLTDDLVENDTKQQSSGSNNVMEDSDIVPTSQDPWHWWNTLRRVCHHHKRLGVALEISADLPAQSVINRWLGEPLKCAIFSTTLFLTNKKGYPVLSKAHQQLAHKLFRLDVQMMITGINRHPDKGIRAYQQYMDHLFQNQQPLTGVEAFAKGYEDYLQCPLQPLADNLESQTYEIFEKDPVKYTSYQKAVFQALKDRVPDSEKDTKISVVMVLGAGRGPLVTASLKAAEQADRKIEVYAVEKNPNAAVTLFTLKEEKWGDNVTIVQSDMRDWEAPVKADIIVSELLGAFGDNELSPECLDGAQPFLKEDCISIPCTYTSHLSPIMSHKLYNEVRLCKDKDKNQDAHFETPYVVHLHNVTRLAPSVPLFTFTHPNKNSLDNTRYKSVGFIMEDDAEVHGFAGYFDTVLYKDIILSTNPKTFSEGMFSWFSIFFPLKEPVHVTAKSELVVHFWRNSTPRNVWYEWCVSEPVTMPIHNINGRSYTIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPV1</accession>
    <name>A0A8B7XPV1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110975052</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110975052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082848.1">
        <property type="nucleotide sequence ID" value="XM_022227156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XPV1"/>
    <dbReference type="GeneID" id="110975052"/>
    <dbReference type="KEGG" id="aplc:110975052"/>
    <dbReference type="OMA" id="PDSQMIY"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022082848.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="35002" checksum="EF92C43E2B7787F9" modified="2022-01-19" version="1">MANQVRVIVWGLPRTCSSVLLKSLTSLPDSQMIYELYTDAYFWGPERLDQQNFPTVEGGDPAIKLSKDGLLRGSASGFDTSISTFDWVRRQLEADYPGKKVIIAKEIAPWLDGRYKDLPKGYRHVFLIRHPFKMFHSFKKINREFLEQKRGHPVGLEEAVLDQLPPHIMTPGMLYKEMTDLWQYIKDSNLDPDPIIVDSDELLQSPQNVLSYLCGQLRIPYTDSILSWEKGFNCTGSWVVSQEHKHLIQTMDSFVNFRNSTSFLKPKGTSKAPDWSTVDPDIRRCVEFSMPYFSQMYDKRGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ40</accession>
    <name>A0A8B7XQ40_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RanBP-type and C3HC4-type zinc finger-containing protein 1</fullName>
            <ecNumber evidence="4">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">LOC110974755</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBR family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022082291.1">
        <property type="nucleotide sequence ID" value="XM_022226599.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082292.1">
        <property type="nucleotide sequence ID" value="XM_022226600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ40"/>
    <dbReference type="GeneID" id="110974755"/>
    <dbReference type="KEGG" id="aplc:110974755"/>
    <dbReference type="OrthoDB" id="261960at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071797">
        <property type="term" value="C:LUBAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20345">
        <property type="entry name" value="BRcat_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16633">
        <property type="entry name" value="mRING-HC-C3HC3D_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20358">
        <property type="entry name" value="Rcat_RBR_HOIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000137">
        <property type="entry name" value="RanBP-type and C3HC4-type zinc finger-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000026">
        <property type="entry name" value="RANBP2-type and C3HC4-type zinc finger containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047558">
        <property type="entry name" value="BRcat_RBR_HOIL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047559">
        <property type="entry name" value="HOIL1_RBR_mRING-HC-C3HC3D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047557">
        <property type="entry name" value="Rcat_RBR_HOIL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="16">
        <location>
            <begin position="271"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="18">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="527"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="531"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="124"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="374"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="478"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022082291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022082292.1"/>
        </source>
    </evidence>
    <sequence length="759" mass="84622" checksum="158A95F753434533" modified="2022-01-19" version="1">MITASKEETLLVLRGAFSQTFDEALGKWKDPFIPAKFYILQRENDFMLRISTDSPRHSDSLIFISTRQIGSVKKISDHLLQVNLRGSANPLEVILKFCLKFNAPQDQDHFFLLLKNAVEELKSRASRDQDMTTNQTPNPTTPQSPTIPTQQASSTQHNHTSGVSSENQQVPRRPPRPAPRYGTEASSKAPMAAKTATLPMAGIGGTASGFEASARGSGVDSLLTTLQRSIASGDGSGASEAAVNLAKKRTKLSITVDEIGDVPGVRSKFSLEVFVEDRHSSGAKIKLLDVNPNMTISFLKKLVFQNYSFPVEVQRWIIGRRIIKDTETLMDCRINSSTPVFLYLISAEKAGITQEETEMSLQAMQAQQMQYMSRRPAPIPGPQRNPFQMRGATAGPTLPSRGAAGREPPRDLATSPVSPLPLVPPEPKKPTAEEVGWHCPRCTLINPPTVPGCRACLEDRPDNYQIPDPDSYIMDPEEKAKQDELRRNEKLMEEMERKQRTEEKRNRDSNFQAILMADTVDLIPNTEEFECLICYTPVPAGEGVLLRECLHTFCEECLKGHILHNREPVIMCPYDDGAYTCPEALLEREIKALVSPEEFEQYLQRGLTVAESQDPNSFHCKTPDCKGFCFYDDDINFFQCPICGKENCLTCKAIHQGMNCKEYQDDIQRRAANDKAALMTKNMLEKMIANGEAMRCPQCSIIMLKKEGCDWVMCSMCKLEVCWITKGPRWGPAGNGDISGGCKCRVNAKRCHPNCANCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSA9</accession>
    <name>A0A8B7XSA9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110975051 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110975051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082841.1">
        <property type="nucleotide sequence ID" value="XM_022227149.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082842.1">
        <property type="nucleotide sequence ID" value="XM_022227150.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082843.1">
        <property type="nucleotide sequence ID" value="XM_022227151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSA9"/>
    <dbReference type="GeneID" id="110975051"/>
    <dbReference type="KEGG" id="aplc:110975051"/>
    <dbReference type="OrthoDB" id="10400318at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022082841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022082842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022082843.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30349" checksum="9BC1337B4443B499" modified="2022-01-19" version="1">MMSSTYAPTLLSNPFEATPEKLFSHLALTQDNDAGDSSNGDLHRDSRVGGDVKKAGDVKQSNSHEDDGLVSGSLRSPMQTRVRRISAELRLSASSNLDNIKRAGKGLSSGLHNVANKLPLPAMPKSLRRRSWHYEEAEENSLLEPDSLAQEEDGEDKMGKAKSKSSESLMRKATKEDGDVTRGGSGDRDRTGKSFLVRKWEARKNKDQESKADDKKDDSSPGEVPETSNQGTEALSVESIPIAFEPLTLGQRPTTPTVTISFDEDPPPKKNSNNPFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSF4</accession>
    <name>A0A8B7XSF4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110975069</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022082881.1">
        <property type="nucleotide sequence ID" value="XM_022227189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSF4"/>
    <dbReference type="GeneID" id="110975069"/>
    <dbReference type="KEGG" id="aplc:110975069"/>
    <dbReference type="OrthoDB" id="5982051at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034417971" description="receptor protein-tyrosine kinase" evidence="11">
        <location>
            <begin position="33"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="127"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="330"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022082881.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="57616" checksum="38E30A2B8A539C2F" modified="2022-01-19" version="1">MDAFTFFRSSMAQLAVNDVLLLLWCFFCSVSAWTVTLSDETHNVYYEEDSEARFTCAVTLEEPKKCRFYATWYYEHGILRDRSLMNMTESSLNTTLSRENLKLTCSVHTGRGEQKNASLDVTVLYPPSSITIEMDSQQLTDNDTATVMIGRPYRFTCNASGLNPANHMMWFIKTQNGVKQAEPCWNSSRQDKDRHKDRDVSCQLDLNITKYHNRVVCRALYPDGKPCKDITVNLLIQHEHPETTTQDLETLSPTRSHISVIIPTTSSVVICVTIAIVFLLLRWHRKYALNVRETTASNELILTEDPAPTGAALSTSNRSRHDYNFPRGKITLLEVLGSGNFGQVYHATADGIYQSGRKSDVAVKILKRSADADVVEDFKKEIAIQKDFTRHPNIASMLGYCMEREPFYLIMEYLPRGNLQKYLRGRKDAWRDNTTEGDIPACPFQLLTFASQVAFGMDFLSTMGCIHRDLATRNVLLSEDLVCKLSDFGLARDVSETEQYEKTSLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTL7</accession>
    <name>A0A8B7XTL7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat domain phosphoinositide-interacting protein 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110975412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083567.1">
        <property type="nucleotide sequence ID" value="XM_022227875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTL7"/>
    <dbReference type="GeneID" id="110975412"/>
    <dbReference type="KEGG" id="aplc:110975412"/>
    <dbReference type="CTD" id="11152"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000964">
        <property type="entry name" value="WD repeat domain phosphoinositide-interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083567.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="40776" checksum="800DC99452A68DC3" modified="2022-01-19" version="1">MSACCLKWGPTHTVVMSKPLCTSVFCFAMATRGILSLRFNQDHGCFSCAMEGGLRIYNIEPLAEKLRLDKDEVGSVAQVEMLHRTNLIAVVGGGAMPKFAENTILIWDDAKKKFVLELTFPSIVLAVRLRRDKIIVVLRTRIFVYSFPQNPQKLFSFDTKPNPRSGLCEVSPSSDKQLLIFPGHKQGSIQLADLANTEPGTSSSPVTINAHQTDIACLAVNQEGTLVATASVKGTLIRVFDTSSRKLLVELRRGADPATLYCINFSNDSAYLCASSDKGTVHIFALKDTSLNRRSTFSKMGFLGQYVESQWGLANFTVPAESACACAFGQQTSVIAVCVDGTFHKYVFTPDGNCNRESYDEYLEIGDDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTU8</accession>
    <name>A0A8B7XTU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110975451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
            <dbReference type="ChEBI" id="CHEBI:78569"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41969"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083657.1">
        <property type="nucleotide sequence ID" value="XM_022227965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTU8"/>
    <dbReference type="GeneID" id="110975451"/>
    <dbReference type="KEGG" id="aplc:110975451"/>
    <dbReference type="OMA" id="CVIRLNM"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001574">
        <property type="term" value="P:ganglioside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906:SF1">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0730">Sialic acid</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="28"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004323"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022981"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00043744"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022083657.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37632" checksum="BD256C3817E89E51" modified="2022-01-19" version="1">MHKSLAFLIGLILTSCLIYILLGSYVVLHYSGRSSSTFHLGRDLLRNATKWTHALVEHDQNPKPSGPDVHGALRHYISLVDNKRTNLSCTSCALVSSSGFLIGKNASKEIDSRSCVIRLNMAPVRGFEKDVGSRTSLRVLNFFMIDVKPEALPNNSRLMVWGLLKRKDHLQDVTKMVKHLSPGSTIHGQTHKGELEAEELYAKETGLHPVKTRSWLSTGWFAMMLAVDLCQEVHVYGMVPADYCARRPRKDVPYHYYDLPHIKECSTYRHAERDKKGNHRFLREKVVFARWAQRYNITFHHPSWPMKFDARLFHNAGLLETILQWIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUD1</accession>
    <name>A0A8B7XUD1_ACAPL</name>
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        <submittedName>
            <fullName evidence="4">Retinoschisin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083847.1">
        <property type="nucleotide sequence ID" value="XM_022228155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUD1"/>
    <dbReference type="GeneID" id="110975572"/>
    <dbReference type="KEGG" id="aplc:110975572"/>
    <dbReference type="OrthoDB" id="9973968at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543">
        <property type="entry name" value="MULTICOPPER OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24543:SF291">
        <property type="entry name" value="SMOKE ALARM, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083847.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12559" checksum="C33F9C39C16D01A2" modified="2022-01-19" version="1">MEDKTIPDERISASSHRDCFRGSCLATDARLNSNKRWAPKSNADSWIEVDLAVRTVVSGVTTQRGPKGVWYVEKYKVSYQRQPSSDRVHVTDQNGDTKVFNGNTSSNTTRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUD6</accession>
    <name>A0A8B7XUD6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Integrin alpha-8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110975433</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083625.1">
        <property type="nucleotide sequence ID" value="XM_022227933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUD6"/>
    <dbReference type="GeneID" id="110975433"/>
    <dbReference type="KEGG" id="aplc:110975433"/>
    <dbReference type="OMA" id="QVPCMLL"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000001">
        <property type="entry name" value="Integrin subunit alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF133">
        <property type="entry name" value="INTEGRIN ALPHA-PS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034540069" evidence="14">
        <location>
            <begin position="25"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="13">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="13">
        <location>
            <begin position="104"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="13">
        <location>
            <begin position="229"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="13">
        <location>
            <begin position="282"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="13">
        <location>
            <begin position="348"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="13">
        <location>
            <begin position="410"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="16">
        <location>
            <begin position="458"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="17">
        <location>
            <begin position="615"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="18">
        <location>
            <begin position="762"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="853"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022083625.1"/>
        </source>
    </evidence>
    <sequence length="1023" mass="111661" checksum="70A3D6610B72BF1C" modified="2022-01-19" version="1">MGRSVRNLLRQVPVLAAVLALAWGQNLDTQWPVIHTGPEGSMFGYTVELHRDGDTDWLLVGAPKAQTPQPDVVEGGAVYKCPVHPPRSPGNCEQIPFDLTGHTVDDRGGQIADKSHQWFGASLKSAGPDGRVVACAPRYTWFYTADMKDDEREPVGHCYVSDGHFSNIVDFSPCETNDIKLWGFKGVTHCQAGFSAEITKDTLVMGAAGSFYLQGQIYVQNLTSNAAPLATPELDPKFDDSYSGFAVALGDFTGDGQPEYVVGAPRGNYLTGKVTIFDKDLQPLAELQGEQIASYFGYAVVAEDVNNDGLDDVIVGAPMFSDRRTTVEKWEAGRVYIYYQNADHSFSEPSTITGEMIRSRLGSSITSLGDVNQDSYNDVAIGAPYQGDNQEGVVFIHLGTPDGLRLRSTQVLRAADFNLQNVTTFGYALSGGLDMDKNKYPDLLIGAQNSDLAVLVRSRPVILLKAFLSVSPEGINLENKTHLLPDGSLATSFEITSCLTYKGKHIPDTAQIQYKLSLDSLKMVNPRALFADGSAPGTNQDITKMELTKNTEWCRENLAYVKAGIRDKLRPISINLEYSLNDEDAVFAPYELQPFLSAESSSVTMEQVYINNNCEDNICVPDLDVKASTSTSDLVIGSSDSIILDIEILNRGEDAFLATLRVVVPTGLQFVRVQRKESDFSITCSDDTEVDTIICDVGNPLIGGTKADFGLKFSSFQLIGDTSSVTFALSAMSENLEASPDKLINNYLNITVGVKAKVDVVLLGRSIPAQVAFTPDGIDNPEIIKDSEAGPLVVHVYEVSNAGPSNAGRTSFDVSWPMRDEDGDFLLYLIRVEPSLGSRCNVQGAVNPLNLTIEEDTQAGGNESVSSTRDVEADRKRRQAEQPEQQIGKADCSTGNCLSISCSIQELKSGESEVIKFVARLWNNTLIETDYDRFEISSRGVARVLDLPYAIPPPELPQVMMEVSTIASPDEPVVKRVPSWIIILAVLGGLLLLLLVILILWKCGFFKRKKYSPVDSDEKRADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW15</accession>
    <name>A0A8B7XW15_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dentin sialophosphoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085058.1">
        <property type="nucleotide sequence ID" value="XM_022229366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XW15"/>
    <dbReference type="GeneID" id="110976230"/>
    <dbReference type="KEGG" id="aplc:110976230"/>
    <dbReference type="OMA" id="NKFARFA"/>
    <dbReference type="OrthoDB" id="10489347at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1170"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="962"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1052"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085058.1"/>
        </source>
    </evidence>
    <sequence length="1238" mass="140661" checksum="981646F874ED1E87" modified="2022-01-19" version="1">MCCVQRNMASEEEDQDLETLRVAVLASFKPKSQQASPSNEAGSPSPDGENEVSEEKQEEEEQDEDALRRAALKSTKEIRLEDIPTPQAPQPTFQLKGNLIAIQPVPEKPVPTHLNPSDRPRLPRNNKFARFASSDSETNSDTDDDSSEEDSDEGSESDQEGLSSDSSKNSSSSDSNTSSSEENDHSSRSSSESRSSSSSSSSSSSSPSSSSSSSTSSSSDSSDSDSDEAGKGHDRKKASQGDLGRRGSISRHRRHEKEGDDQRRDHREQQHPERSGRDRDRERLRASPRRGRDSWHSRHRTSPKSGEDLHSYRSSAPGRSRRDLDRLRTRSRSPRIRRDERVLRTRPDGSRGFGISESKVPSVNESLQSRLLKLASYESSGSDRKRDIREFSSRSHRSGESRTGRIDHRRNSDISKRSDEKSDKKLGSPKAKRTSSNSDSNSSSNSDISLSDMESESDKETSRFKHAKGEKPQGEVDVRHRAIPRSYRDDFSRGDRRGERGREEHRRRDDRYRDGRRIDPGRTRDERRDRDEAHKRDTDRHRDSTKSRNGPMSVVKSKTVDEPSAKKIPSLLDIKVRNPNLDPSLRPDLKIISRPEPNSTSNTRRHDRSPTAREKFTSPERLKDLEKNFESESGSEDENVPAGPRSIVKVDKRRDLKSRLGVRAAITDPAKSADVAGQKRDGDSKGQSEHVQKERRKRKSGDSRTKDGLGEDFKMEGKGSAVRSNSPEIRITFNEGPPAKRKPIHERLGIKGAGSSKPRRSVKDRLGKMVSNPKKAPKDPIPATSAYDDDDPLESQIPVQVASKPRQSVIELKTRAKQDAESKRQTQKQEAEIQKQKKQGETKNFDDKSKYYAKLEKQQKNFKTEVSQRKPKDISKNENSNNEHLERVELANSETNTVEEGNENPLQVKFPKEEQHLQGKSHPKDGMKKQEIAAEVKRNTKIKLRRDSTQRAKTVEVQVSMKRGDIQENKEEKVLEEACSSRKEADGMASDNEFSQEAVHSGSPHQNDRKVISDSQKSGRNIVRTESPHPIRQIVYSKSDKSNRNVISADYDTSKRKIVHEESKLTEVVESEASQRKIVHDESKHSQRRVYQSDVDSSHRKIIRDDDPARRKILHTDLDSSRRKVLQSDQDLPRRTIVKDSDMKRGPSPSFSYDDIRQPKMSRSSELWKRECIEEQTREVEMRMEKEERMVIEETREAEAKRLKEEALNAKIQKIKEKNAAILQRHKEIEAEKLMFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWA3</accession>
    <name>A0A8B7XWA3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">M-phase phosphoprotein 8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084116.1">
        <property type="nucleotide sequence ID" value="XM_022228424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWA3"/>
    <dbReference type="GeneID" id="110975716"/>
    <dbReference type="KEGG" id="aplc:110975716"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084116.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="24607" checksum="A06D5E3709700132" modified="2022-01-19" version="1">MTLLAMVSQFMTPNPDKTWAERVEQILATKKVRGRTLYKVRWKTYGPKDDTWEPLSHLKGCQELLEQFRAKEVSQKALQKASSQSQQKAVKYTQLGVKQSVGDMSSADGDRVGMNDVDGQVTVEDRGDREVDMSLRRSALRRRVRTDASPLMMGDAQFMQETTESTQEEVSSIIAFSLHVDSDCTIRKKVCRCKDQFGLCLFSPQLTKFYRFFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXW0</accession>
    <name>A0A8B7XXW0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110976016</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022084626.1">
        <property type="nucleotide sequence ID" value="XM_022228934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXW0"/>
    <dbReference type="GeneID" id="110976016"/>
    <dbReference type="KEGG" id="aplc:110976016"/>
    <dbReference type="CTD" id="201595"/>
    <dbReference type="OMA" id="TKELWSP"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="445"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="20">
        <location>
            <begin position="72"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="21">
        <location>
            <begin position="604"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="784"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="791"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022084626.1"/>
        </source>
    </evidence>
    <sequence length="842" mass="95582" checksum="FE5F8E9B3680615D" modified="2022-01-19" version="1">MAEHSGQYDAANTGKRSQNQLQMAPKSLGNRHRHVQKSIKNQDSGEGVELAESPENEQLRFPTTSKAVEGLLTFLILFLACLAAFSSRLFAVIRFESIIHEFDPWFNYRSTHHLVSHGFYNFLNWFDERAWYPLGRIVGGTVYPGLMVTSGAIHWLAHLLHIPVHIRDVCVFLAPLFSGLTALAAYGLTKELWNPGAGLLAACFIAIVPGYISRSVAGSYDNEGIAIFALLFTYYLWLKAVKSGAVSWSAATALVYFYMVSAWGGYVFIINLIPLHVCVLLMMGRFSYRIYVAFSVFYILGTVFSMQVPFVGFQPVRTSEHMAAAGTFALLQAYAFLKYIQDFLSKKEFRALFFFGVMGTAGVVFLAVVLLTYAGVIAPWSGRFYSLYDTGYAKIHIPIIASVSEHQPTTWVSFFFDLHILVCTFPAGLWFVIKDINDERVFIVLYALSAVYFAGVMVRLMLTLTPVVCILASIAISKTLTEYLNNENTDKKKDDEEGGEETEEDEEEVDRKNRKLYDKAGKVRKPKLDQDKDNEGLGTNLKGFVVMAILMMLMMFAVHCTWVTSNAYSSPSIVLATYNNDGTRNILDDFREAYYWLRKNTGERDRVMSWWDYGYQIAGMANRTTLVDNNTWNNSHIALVGKAMSSNETEAYKIMRALDVDYVLVIFGGVIGYSGDDINKFLWMVRIAEGEHPKDIRESDYFTVNGEFRVDSSGSPTLLNCLMYKMCYYRFGEMQLDFRSPAGYDRTRNAEIGNKDISFKHLEEAYTTEHWLVRIYRVKPLENREPSTTKATKKSKRKFYSKKTSKRKRGSIKNKPVVKKGKRKTAARKTSPKTTSKKQRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZ33</accession>
    <name>A0A8B7XZ33_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110976500</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110976500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085512.1">
        <property type="nucleotide sequence ID" value="XM_022229820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZ33"/>
    <dbReference type="GeneID" id="110976500"/>
    <dbReference type="KEGG" id="aplc:110976500"/>
    <dbReference type="OMA" id="HELCESN"/>
    <dbReference type="OrthoDB" id="10051210at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022085512.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47294" checksum="3B5F13C7E357E4F3" modified="2022-01-19" version="1">MKIRTLLATGGFNIRQWASNIPSVVADLPAAARSDGFDLWHVFGQSDTPEATLGLQWKCDADDLGYKHRPIAYQMLNLGTVYKIMASQYDPIGFVAPFTARAKVIVQDLWKSKRTWDDPIEFGDILTRWHTWEQELADLPKLRLPRCYTPPEVDTKTTNREVHIFSDASERVYGSVAYLRTEGHKGSIHTSFILSCSRVAPKGQLSIPRLELSAALVGAQLANLLRKELTLSIQKITLWSDSTTALCWLKSDSCRYKVFVGTRVAEIQSLSNPENWCYVDTANNPADDITRGKTVYELSNEQRWRNGQSFLSLPPHRWPASPLVDEPDDTVELKGATFCGAITVKEPQLPNPEQYRSWNGLIRAFKELHDAAATADISPSTLVKREEVIEIKLLLQVQVDCFPQEVHALMQNKQLPSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZ41</accession>
    <name>A0A8B7XZ41_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Amino acid permease 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110976241</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085034.1">
        <property type="nucleotide sequence ID" value="XM_022229342.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085036.1">
        <property type="nucleotide sequence ID" value="XM_022229344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZ41"/>
    <dbReference type="GeneID" id="110976241"/>
    <dbReference type="KEGG" id="aplc:110976241"/>
    <dbReference type="OMA" id="LERMINY"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF703">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="44"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022085034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022085036.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53388" checksum="E53B150625CCE390" modified="2022-01-19" version="1">MDQPKAADKIPLMLEEHASYGDRDATPPDNGDQDDQEEPKGLTFWQTFFAGSGIISGFSVTVLMTVIIYTGWLLGITIYVVVVLLLTYTGTLLGNCWEMIGKNCRDDRHPYGAIADQACGKIARMAINTVVDLNIFTANVMMLLIIPDLLYIIAGPSVHGTFCYWPLAFGLIVLPFMWLGALKDLWQLGAISYLGCCLAMVFLLINGARQIPKSLGWRQHPFNQWNVSLDTRDNDPPSFYLGWLVSLVFSTSLFMVSFHFAIPSIQRGMHRPQTFNKCLVTIYSVFSLISIPTLLVVFFGFGHLFANFKDSGVSILYIMPRDDMVITPAFLLLVNSLMLMVPASNPLFQHYEEILNIPEECGWKRLVFRTLVVLLEIFFAETIPQFSVFIAILSGLFIPPLTFLAPALFYLRLRTMHRADSSSTRPFHHMCETVACVVLIVASPVVMVLTIVITSEAIADGDTLFVAPCYVDPKAAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZE7</accession>
    <name>A0A8B7XZE7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Short transient receptor potential channel 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110976301</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085136.1">
        <property type="nucleotide sequence ID" value="XM_022229444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZE7"/>
    <dbReference type="GeneID" id="110976301"/>
    <dbReference type="KEGG" id="aplc:110976301"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
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    <sequence length="1081" mass="123259" checksum="BADC66833732CC94" modified="2022-01-19" version="1">MANHSNRNHCRMDFVNTPTTKCSRKDKHRKEKSVFFIEPQDRETRVSHPTMEMDIGPGRFDSMEKLFLAAAENGDKKAIMYALEKAPDLNINCSDKDGRSALVIAIQNGNSDIIKLLLEHSVQLGDALLRAVDEQFTNAAQMICEYIKQKNIPEFLNCRALNGDFHPDITPIVLASHHNNYDIIKILLEYGARIEDPEFYAFSTQTQTLQHSLGMLNIYRALASQAYISLTSADPIHTAFEMCVKLRKLSRKNPEFSEQFVELAGQCEQFAADILGHIRNHKEQTCILYHDPYLWGAYVEGNGVGPYKVKIAIHYEQRKFVAHPHCQQRLTQLWYEGLPRWYDSNWLSSSFFSAIVAICFPILSILYIIYPWGKVGAFMRIPHVQFVCHTSSGLFFLVLLGLQSSGGQDEDADGNPVDSRTLEPTFTEWLVICWVIGLTWAEIKELWYYGSRYLTDRWNILDFLTLSLYWASIALRVVVYLQALERTNALMASTANTTMHPITTDTMTIWTPTDDEDDFTPSGELPSSMPPEVDSEHLLQAIQELTTQIEILKEDQKNKDGEIADKLVLIDGTISKLDSRMATFIESQENDGGAFGGSTGSRRRTSSGDSYIYTPSDNRTGSRATWNSDDPMLISEGLFAIAKVLSFLRPISLTVMNRHVGPMQISLGGMMFDIAKFMLIFLFVLFAFSLGMNQLYGYYASEMIAKCSTCRMYFSSLPETMATLFWALFGLPDLEILDLKGVPHTFTEGVGVGLYAVYHIIAIVVLMNVLIAMMSNTYTRIEEDAEIQWKFSRSKLWMTYFEGRGTIPPPFNAIPTPKTIGYICKWTWDRMHGAQSRQEKKERSKAFMEEREKQYRDIMGKLVKRYIFDAKRDDEEGNQEQWVNRIKQDISGFKYEMFEALSGMDSKMQDMEHRIANGPTDTKVGTQMYQKMHEIVKKPLSRPDSMESVKSGCSELCKAASQDLLDSRNSEMNSMPIYDTGEMESPSTKNRYKPKSPSLPANIASYMYPPEWERYEPIRYIDEDPEVPLLGSPRNSISSNKKRGSSRRKRRHSTTHLNHLGSISRNNKDVVENALESTTKV</sequence>
</entry>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y021</accession>
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        <name evidence="4" type="primary">LOC110976409</name>
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        <property type="term" value="P:regulation of lipid metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
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        <property type="entry name" value="Mito_Ser_Protease_LACTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46520:SF1">
        <property type="entry name" value="SERINE BETA-LACTAMASE-LIKE PROTEIN LACTB, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="127"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085341.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="64594" checksum="01FDDEE6315E7CA5" modified="2022-01-19" version="1">MCGTADLSLTCAYQQRKKEGGPRSGGLTSGIKECLKSYSSKARLSSGFQRWRTPILATVGGGMALGVGLVTSLWYDHLHEESPLGIQEAGCKEKAKWKDKDTFGDAVWRQEIFGKAGLKEAMKRSRDLLQRAKDEVGSPGIVAAVSINGRLVWAEGIGYADVENRLPCSSDGVHRIASISKSLTMTAVAKLWEEGKLDLDQPIRHYVPEFPEKEVDGKKVDITTRQLVSHLGGIRHYNKDYIKKLGNQSNKEGISKLTKDSKIFSKSDKSKDTPKNTEEKGENDTKETEFYITKDYSSVIDALDVFKEDPLVHKPGSKFLYTTHGWTLVSAIVDAAADEDFLVYMKKIFKDLGMSHTVPDEASKLIYNRARGYTKNKKGKLINVPAVNLSHKWAGGGFLSDVKDLIQFGNAMLYSYQYTDEHRDAGLPQGYLQPETMKTIWSPVPLTKCSWDAEGVYTMGWAVRERGKQQRGLCPEKHQMVSHTGGAIGASSVLLIVDCSRPEIVSKGQPVKNNSIQDDILKRSSLGNSPTQNDNSMKHDIASSRDLSLPKGIAVAIIVNLDDIGLFKTAVDIAEEFQKVNHIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0H2</accession>
    <name>A0A8B7Y0H2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC110976645 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC110976645</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085794.1">
        <property type="nucleotide sequence ID" value="XM_022230102.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085795.1">
        <property type="nucleotide sequence ID" value="XM_022230103.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085796.1">
        <property type="nucleotide sequence ID" value="XM_022230104.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085798.1">
        <property type="nucleotide sequence ID" value="XM_022230106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0H2"/>
    <dbReference type="GeneID" id="110976645"/>
    <dbReference type="KEGG" id="aplc:110976645"/>
    <dbReference type="OMA" id="PCGLMER"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF43">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022085796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085798.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="61560" checksum="ED23F463899F8A3A" modified="2022-01-19" version="1">MGFKTVIGIVFVAVIVTVLVGIPKSPRTIPPANPDDPERLREGVVKKVLIIGGGLAGMSAALDLAERGYQVTLHEADSALGGVYLQSKPVQKLGQTFIVDRGMQAWFHNFHNAWDMIRRLGVEDNFRRWEAHDVVYRNYKPERMYSHGIFPLNLAGMIFRSPNLNLLEILLWLRCAWDFINYNHDTNFKRWDSISFDEYMDMFDIHRGFYDIVLEPGMKASYQDKSTFSAAEMFLFSHMFYVSNPQADYRDIAKMNQATAIINPWADKLRSLGVKIEMESAVESLIFDKKGKIVTDSKHPSEHYDHVILAAGLNSTKTILRNSLKLLDDSKDKSTHNRLSKVLEKHLMKLPLAPPFKVLTVWFDKRLESKYNPDIVQTPSFPPITIITQYHKIREDYAQWANQSGGSVLAFLMFAWEHGEVADDKLWNFIAPTVREIFPEIFQRGFKVLAYHVDGSATYPSYEKGLAKYRPTVTFPKECGFPNLLFAGNWLHANYPTALIERPIATGREAANQILLSDHVRQSSLIVTDSHGPGFFQYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0L1</accession>
    <name>A0A8B7Y0L1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Neurotrypsin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110977149</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086703.1">
        <property type="nucleotide sequence ID" value="XM_022231011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0L1"/>
    <dbReference type="GeneID" id="110977149"/>
    <dbReference type="KEGG" id="aplc:110977149"/>
    <dbReference type="OMA" id="PPYCTIL"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034025249" evidence="10">
        <location>
            <begin position="25"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="11">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="195"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="302"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="327"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="340"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022086703.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="43157" checksum="3B4CFCAB9034774F" modified="2022-01-19" version="1">MMAPPYCTILTALVVVVLTGLCFAHPVSNTPAPARRTSVPCVSGPLGMESGAIQDSRITASSVYGSSFAPNTARLNVGSNGWIPSTPADQWIQVDLGRHVAITGVVIQGYSTGSSHYITAFTVQYSASGGSDWQDLRNADGDIIRFSVSSGRPTNVTFPVVPMARYLRILPQIWDYTTYRVRFEVLGCRVSDGSLLLVDGEDALSGRVEIYHESTATWGAVCSNGWDLSDANIACRQHHRFLEAVQAGASSAETDLPIVMNRVACKGTENRLVDCPFICTDYQQCNSSRTATVVCRPKMNTVRLVGGSNNSSGRVEVYRNNTWGSICDNDWDINDAAVVCRFLGFSGAQAAKSGAYFGQGSGPVHMDGVACTGSEGNFGDCPSSCWAEPQCSHSQDVGVICQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y256</accession>
    <name>A0A8B7Y256_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc transporter 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110977431</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_022231567.1"/>
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    <dbReference type="KEGG" id="aplc:110977431"/>
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    <dbReference type="OrthoDB" id="78669at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="15">
        <location>
            <begin position="37"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00046010"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01545"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022087259.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39861" checksum="6C34FC4B066F3A6B" modified="2022-01-19" version="1">MLPIHNKDETYVPGFSVKEKISSWWRAIFSDPTSRNLFMFLLLNLSFAFVELAYGVWTNSLGLISDSFHMFFDCTALLAGLTASVISKWRATPTFSYGYVRAEILAGFINALFLLFIAFFIFSEAVERFLEPPEVRHERLFVVSVLGFIVNLIGIFAFQHGHGHSHGGSAANGSVGHGHSHGHGHSHGHGHAHGLGMGFKDDGEHQYTPESSQKEIMHGVFLHILADTLGSVGVIVSALLMKYFGWLVVDSLCSMFIAVLIMLSVLPLLRDSSAILMMRTPYSLDKELPGCYHRVTNLDGVYSIHEPHFWTLCSDVFIGTLKLEVAPNADIKYITSQTHNIFTQAGVRQLYVQVDLAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2Q8</accession>
    <name>A0A8B7Y2Q8_ACAPL</name>
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        <submittedName>
            <fullName evidence="4">Hematopoietic prostaglandin D synthase-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">LOC110977532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_022231767.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="F:glutathione transferase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_S-Trfase"/>
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    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
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    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
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    </dbReference>
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    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="81"/>
            <end position="206"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
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            <dbReference type="PROSITE" id="PS50405"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022087459.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23483" checksum="AE889CD71C23F8EF" modified="2022-01-19" version="1">MVKYVLHYFKANGRAESIRLAFKLAGVDCEEVNIEFSEWPKIKNRYPTREVPALEVNGQMLCQSKAILRYLAQEFGLYGKTNLEAAFIDQAIDMVEDIWAAANHTFGGADIILKDKAEPFLREIIPSIYASLERLLALEVAGDFFVGNSITAADLFFFTAIDFVDVMSKGANSLEKFPKLDALKRRIAANPKIAAWLDVRPPEATFKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y309</accession>
    <name>A0A8B7Y309_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Non-POU domain-containing octamer-binding protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110977607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Echinodermata</taxon>
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            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_022231872.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM1_p54nrb_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12333">
        <property type="entry name" value="RRM2_p54nrb_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="paraspeckle component 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000513">
        <property type="entry name" value="Splicing factor, proline-and glutamine-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08075">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="145"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="219"/>
            <end position="300"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="396"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="494"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="545"/>
            <end position="642"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022087564.1"/>
        </source>
    </evidence>
    <sequence length="642" mass="73008" checksum="7A8AA3181ACC92B6" modified="2022-01-19" version="1">MNRGRNDRPYRGGQRSNYDNRKNTQQRPAMKKDQSGTSGLSSPSNARPTSAGGNPSRDAGQEPNVAKPSPKDMTKEHRAHTDTKQENKPLERSSSSMSSGDRDRRHHQRDHDRRDDSGQGQHAQDDEMMAETSSRKPEKKFTQRCRLFVGNLTPDTTEEDFKSLFAKYGEISEVFLNKTKGFGFIRLDTRYNAEAAKAELDGTTRKNRMLRVRFATHGAALKVKNIPSSVSNELLEQAFSQFGVVERAVVIVDDRGRPTSEGIVEFARKPGAQNALSRIKEGVFLLTSSPTPISVEPLEQRDEEDGLPEKNIPKNQAYHHERENPPRFASPGSFEFKWGNRWKALEETERLQREQLERQIQDNREKLDSEMEISRHEHQTMMMRQELLRRQEELNRHEETQREMQLRRQEQMRQRDEQRRREEALMKQQQQEELMRRQQQGSGLSLSQQEMRRRQQSEDAVRHANLRVGNESRQQQQQQQQLQLIPHVNEQQGIGSKTQLQQGLQMRGSSGHQGQMNQAGGMGGPGNQGLLANPNMQALQSLQGLAGGNSNVGRMGPGQGQPIQTRPSRFDQPPQNMGGRGQAGPGGMGGPQQGGGSYAGGSAGGPRPLEEIRTRPPPSMDRRDMDRRDRHEDYMPKRPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y531</accession>
    <name>A0A8B7Y531_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Tetratricopeptide repeat protein 37-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110977280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086951.1">
        <property type="nucleotide sequence ID" value="XM_022231259.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086952.1">
        <property type="nucleotide sequence ID" value="XM_022231260.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977280"/>
    <dbReference type="KEGG" id="aplc:110977280"/>
    <dbReference type="CTD" id="427114"/>
    <dbReference type="OMA" id="CQWELDP"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="859"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022086952.1"/>
        </source>
    </evidence>
    <sequence length="1556" mass="172645" checksum="035F995BEECCA289" modified="2022-01-19" version="1">MASSGSSTKEVKQLLKNAREAIRNKEYKEALKHCKSVLKQDKNNYNALVFVGVAAAELDQPDQAVAAYKKAIETDQQQPLAWQGLAGFYEKSQNPGHQPELADVYSQLRELLKTKEPKKWQEVSEKLARLHCELGDIQQAVQVLRSIIQSKEMEDPSTRLGYWIQLANALAGAQELPDEYVTLLERAYKTILKSGEDKQQHFCSYIKFLTKRNDIGDELVKTECLKMHELFPSDPYPLTILAGIYLQHSPECLDQVAVSVYDKLQTLDDASTVALLGIGQASLAKKDYLLARDRLQQGLKGSRKSVHGWLYLARAQLGLHDNQASVESTHEGMKALTGNKKLAASRLKRELLMVQADALLDAGTLTQTQKALQIYEKLLEQTEDSLQLGITCGLCTSLLILGNTEKADEIYKRALLIDANDSRVIALQGQIFINQKQLDKAEQRFIQALEGAPDCGLFHLWLGKVYWQMGRQTRTDRSKMLASLLKAAKLDPYYSDTFLYLGHFYWQVAGDKSKGRKCYQKSYELNPQNEVAAAALGDACIELGEEDAALQLYRNVTKAAAAGTAKWAWLRLGLYYHKQGSCNDAVASFQAALRADPKDRHIWECLGDAYMSRGSYTAALKAFSRGVELDPNAKYCLFQIAAIKQTLEAYAEAVTEYQVILDSDPDYIPALKGQGETYVRLARSSLHQYFNGRVVDYIKLAIQVLARAASLRPDLSCVWKLLGDACTMLHPLSDKLISVQVPTNLLDHSFHGEASQNKKQLLCIGARCYGRALHLQSSCASLWHDLGRNYYYQSLSDLNNSAQLAVKALQCLKKAVVVDSTNHNHWTALGVIAAGKDVDNPALAQHAFIKSIQVEANNVVAWTNLGALYLTKGNMELAHQAFKISQSLEPSYVNCWIGQALVAESSVPEEAMDLFRHTTELATHSEGAIGYAHWVCQTLLDPSLDKTSERYRYNIVQMDAVSMATVGLDKVTDRIQNDACAYTMYGLLLERQGLHKSAEKAFARALELVHDTRDQERLNLAKANHARSLCSVGHYEEAIKQFQGITPLIRLEEICNLALALYKTGNMQASYQAYEQALQLAGDGGLRSQLLTCLGMVAFQCGDSNQAKTLLFQSSQESEPAPEGLLALLALGVHQEDMTLATAAVAELQKLKDKHGFVADVAFAGAVLYALQGQFHLACRQVTKATGRHPGLSELWRLMAEVILQLLPQKAKAAIVCSHASLQDKEISKESVSTYALATLAVGQHGQLIPANQRCLSAAQKSVHIYPDSLENWAALSASYLSHGIWNATQNNKQHDDSNNLASKLATFVQSWAEKCGNSAIQQWAGLQVVVSLMHEGRLQRADALTRKLEVIYQSQPDIKSALQLLQAQAVCMQHVSSQSIELLRTVISRTSYQSLAAWQLLAKLYEQEGMVAAAESAYRQSLVHSHGQQLVPLLRLAHLALRATKASNEEHWAALVLEATNEALKLQPTCPIALLLQGLLHQHKGNTRQSKKCFQQVLEMSRGDQMNLARSVARYHMMQHYASKKDANTAQILVEEAIQEQDPNLHLLQELVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5L3</accession>
    <name>A0A8B7Y5L3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977375 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087126.1">
        <property type="nucleotide sequence ID" value="XM_022231434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5L3"/>
    <dbReference type="GeneID" id="110977375"/>
    <dbReference type="KEGG" id="aplc:110977375"/>
    <dbReference type="OrthoDB" id="10402547at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034697274" evidence="1">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087126.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="11925" checksum="72BA34C884597ADF" modified="2022-01-19" version="1">MASSSLAVISTIAVVLAVLSTLTPSQAGKLTEHQLMLLQGGGLNGKRSQTGMRPQHYLNLMDGAEGSEEFEREPVENLMAGYLARLSPGKRHMLSKLLEVARMDNELSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5R8</accession>
    <name>A0A8B7Y5R8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110978116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088539.1">
        <property type="nucleotide sequence ID" value="XM_022232847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5R8"/>
    <dbReference type="GeneID" id="110978116"/>
    <dbReference type="KEGG" id="aplc:110978116"/>
    <dbReference type="CTD" id="9349"/>
    <dbReference type="OMA" id="MIQMQTR"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022088539.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="14775" checksum="B2B31A3C357BC1E6" modified="2022-01-19" version="1">MSKRGRGGSSGSKFRISLGLPVGAVINCADNTGGKNLFVIAVKGVKGRLNRLPAAGCGDLFVSTVKKGKPELRKKVIPAVVIRQRKPFRRRDGVVLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5Y4</accession>
    <name>A0A8B7Y5Y4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Probable splicing factor, arginine/serine-rich 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088608.1">
        <property type="nucleotide sequence ID" value="XM_022232916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5Y4"/>
    <dbReference type="GeneID" id="110978156"/>
    <dbReference type="KEGG" id="aplc:110978156"/>
    <dbReference type="OMA" id="MPKNTLY"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022088608.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="30916" checksum="1095CC5C0134E7A5" modified="2022-01-19" version="1">MLTEGRLYVGLLNPDTTKQDIEAEFGRYGSLRDVWMARNPPGFAFIEYDSAVDAERAMRDLDGANLLGSRIKVEPSKGNQRGGRGGRGGTRGGGDRRGGGMRGGSREGSFRGSRGSRDWDSRGGRGPPPSYGSYGDYPARGGGGAYRDEPKARYGADQYGSRYDSAAYRSRSPIRRRSPPPPQRGRDFGGREYGVMSREYGGGRDYGGGTADYGPSARDYASPRSYAPRDGGRDFDREYRAPVAGGGASARYDRGEFDRYSRYDRAPAAYTDRSRRSPLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y645</accession>
    <name>A0A8B7Y645_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110977844</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110977844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088017.1">
        <property type="nucleotide sequence ID" value="XM_022232325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y645"/>
    <dbReference type="GeneID" id="110977844"/>
    <dbReference type="KEGG" id="aplc:110977844"/>
    <dbReference type="OMA" id="CTSERYH"/>
    <dbReference type="OrthoDB" id="10066203at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="67"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022088017.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="53099" checksum="10C4A406052E2196" modified="2022-01-19" version="1">MVACDASGCKIEWFHYQCVGLTADTIPSGSWYCDVCKENDMEIELDLHAVDDGYKATAEDDIAMEASASAEVVTPDPAVSTTDTAKSASSSSTSTKIEAQGSDKKAKTAMKATNKKSCKEKEKKSKKKASSPVKRPAQRFTVEHAKTNAAEYVKAALERIQNHPIFTGTYPLAVLAMTLVTSVLQVQDSSAFTDFSVTLVTALWFVATAGDDKFLQPEAMDVVWKHFHKFKLSSIHEWKSFLESISICTDGNHIHIVYQHLLLSVITLLIKDRHATDLPVAPSNSQVSISNISKEEEQVLRYVAGYVPFALFEKFRKQLNETSSVFCSILATWRSCTTDTEQTFLEYTNKWIQAQNRGGLFNINDDVYVFFRTLENEARQFLSKGNLEEFIGKNIKRSLKEKMMSQSRVHNYWCNLTREKISGDVSKRLLDIVVNLYIKIRIKAFLKVYLNLKKAAGQASKKAEKALRKELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6Z4</accession>
    <name>A0A8B7Y6Z4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Troponin I-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110978016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088332.1">
        <property type="nucleotide sequence ID" value="XM_022232640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6Z4"/>
    <dbReference type="GeneID" id="110978016"/>
    <dbReference type="KEGG" id="aplc:110978016"/>
    <dbReference type="OrthoDB" id="1679758at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005861">
        <property type="term" value="C:troponin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09358">
        <property type="entry name" value="LIM_Mical_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001978">
        <property type="entry name" value="Troponin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038077">
        <property type="entry name" value="Troponin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00992">
        <property type="entry name" value="Troponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90250">
        <property type="entry name" value="Troponin coil-coiled subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="381"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022088332.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="53743" checksum="16BAA8DC91CA81BF" modified="2022-01-19" version="1">MGDVGYDFAADDRARRREERRRRRAEEKAREERERATFEVGRVASFRSSRSSEPEVEVKLQNNDQSSEEDSSGGSAKSKLLKKTPTRMSRESWEDKQEFSEVELRLEAIRLKREQENEERYRERLEERRLAKERSELQRQELEERRERRRLKQEAEERRQQQEEEERRAREAEEARKLREEIQKRRQEAEERRRNIQNSLSYIRPKYNISDSILQAERERSMTPEEQAELKARTLEEQVPPLDISAFTSAERLRELAMDLQAKLRKLYAAKFDLMKRKQRQEYDLTELNTRIGDLTKAPPLKKTYVTTFKFGLVSKIKEKGVFAEDKPLRKTFPQERNEGKVAGSGMQDRLNMFQNKTDHSEDQPDIKRSGRSTWKAPAHDKCCICDKSVYTLERLEVAKKIYHKQCFKCQYCKKITSLSEYAVFEGKIYCKPHQLKVEQESLRHGVTPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAF7</accession>
    <name>A0A8B7YAF7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110978676 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089537.1">
        <property type="nucleotide sequence ID" value="XM_022233845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAF7"/>
    <dbReference type="GeneID" id="110978676"/>
    <dbReference type="KEGG" id="aplc:110978676"/>
    <dbReference type="OMA" id="LVNAAMC"/>
    <dbReference type="OrthoDB" id="9986749at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF15">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089537.1"/>
        </source>
    </evidence>
    <sequence length="409" mass="44425" checksum="47EDDB1543F220F7" modified="2022-01-19" version="1">MDDDFVCITCKQLALPDGETLDGKIHVIVEDGKIAAILDQEADLVKSAKTHYYADIVTPGFVDIHHHGLGGADDLVQFWSNPAHTQTRLVRYGVTSFLASMVFPKDLEAPSVYNTLKILEGIVGETGQGSTCEGIHAEGPIVNDFGGLPVGDNEMPIAEFKRILDAMPSCRIMTISPHVDAKSNYARIKMLLERGIVPALGHDRLASEEEILGALKIKPSVQFHITHLFNVCSFHHRNPSLVNFGMTDRFPSLPGYEKLAPPTVEIIGDMVHVHPLAVSNVLSSRHFNQVAFVSDCTAEAIPNKKMAYSNREMTVTPDGKCLVIEGTTTLAGSCCSCLDAFRSLVKIFHTGIGKAAAMVAENPARIANLEGIGAVKVGNRADLLLFDDDLNLQKTFVCGQSVYTAKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YC54</accession>
    <name>A0A8B7YC54_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110978517</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="RefSeq" id="XP_022089266.1">
        <property type="nucleotide sequence ID" value="XM_022233574.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978517"/>
    <dbReference type="KEGG" id="aplc:110978517"/>
    <dbReference type="OMA" id="NREDYQQ"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000012">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="322"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1436"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1436"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1479"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022089266.1"/>
        </source>
    </evidence>
    <sequence length="1741" mass="196031" checksum="583CE8628BB2A5E4" modified="2022-01-19" version="1">MSAFRNKIANKRMQSVTFSSYSSAELCHLSVKEVTNPRSFDELGHATSGGLYDPVFGPSDRNELCDTCFLSSLHCPGHMGHISLPLPVFNPLFFRLVFQLLRATCLKCHTLQPPRWTMQLVKYQLRALDRGLLNLIDHMADLVKQTLAETEDKDVVLADTVETALSDCLDAALKEEQDQPCHLPKSRHIQDRRRQLIQDFLQQHLLPRGRKCYRCGAHMRDMRSEHNSRILTKTGEKKTTLLTVFISPQEARTHLRKVMKKEGSILRCLFGMLKAVEFDGDKENSEATEETTDEILCLTEDAMDEAEGGEQTDEVEERSAADLFFLDVIPVIPSKFRPITGVMEKKFDNPQTANLAKVLKDCQTLRVLLRIMGRQGEERQQGEEQQQGEEGSKTKEQEENDKSILASIPGKTNAEKLQNAWVTLQTHVNTVVDSNLDKLSRDKQPGIKQLLEKKEGLFRKHMMGKRVNYAARSVISPDPYINTDEIGIPEIIAKKLSYPQPVTDWNVRELREAVMNGPNEHPGALLIENGDGSQMRLSAWNHSQREAAAKQLLVPKNIHHGPNWQKKVHRHIRTGDIVLLNRQPTLHKPSIMAHKVRVLPGEKTLRLHYSACKTYNADFDGDEMNVHFPQNEIGRAEAFTIANTSEQYLVPKDGTPLGGLIQDHMVAGVKMTVRGRFFNRADYQQLVFSALTDHPTEIRLLPPSIMKPVQLWSGKQVISTLLLNVIPEDLPAINFKGKAKIGSKSWTQVKKGPQLTSSRGTPLTGLSMTESEIIVRGGELVCGVLDKANYGNTCYGLVHCCFELYGGQVAGKLLSCLGRLFTTFLQQFTGFTLGVQDILVTEKGNAKRRKLISKAKGIGPEVVSNALDVEDASNLTALKERYEEAHRKSDDTELREIDLKMKGQTDRFTNEISNACLSKGLEKEFPDNNLQLMVLSGAKGSQVNCMQISCLLGQIELEGRRPPLMASGRSLPSFLPYDPSPRAGGYVDGRFLTGIRPQEYFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVVNYDLTVRDSDSSVIQFRYGGDGLEIPKTPFLTESQFPFLLDNSAASLGRRYKAEDCDAAAARRLQKQVDRWVRKNGAVRRKERCSPFLNFAAKKLGILLEERKEREGGEEKKKTVREELVSWWREATDKERYGKNTSRCPEPVHCQLRPDIQFGAISEKLNAIMQDYLSNVGVQHLEKYGSSGHEEEDLTPKERFRQLLYMKYRRSLCQPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLVEILMVASANIKTPRMDAPLLATSHARKRAARLKKKLTRVVLAQVIEDIHVYESYEIVSAIEQFRLFKIQINFLPHSEYKDDLYADPTSILHYLEKRFLKRLSETIKRKTRDLMKLQLVNNHDAKAANENAAGDDSANQDEPLEPVAMEAEEDSMSDDEEGGDDQEEREYEEDGEGEQENQSSDEEEGEDTGSHGDRGSAEDEDTTERGTAQEEEEGVLRKKRKKSRGVPDSEKTVRIDDALHISPFLVSYDFDSEKQSWCEFTLKLELAYSHLDMMSLLHSETQQAVVHEARGILRCIIADGDKEGEKVLQTSGVNLQELCKHDKVIDIHRLYTNNIHAMANTYGIEAACRVIIKEIQDVFKVYGIYVDPRHLSLVADYMTLEGTYKPFNRIGLEANSSPLQKMSFESTMHFLKQATTQGVCDNLQSPSARLVVGRVVTGGTGCFDLIQPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCA2</accession>
    <name>A0A8B7YCA2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein YBL113C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110979414</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090878.1">
        <property type="nucleotide sequence ID" value="XM_022235186.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090879.1">
        <property type="nucleotide sequence ID" value="XM_022235187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCA2"/>
    <dbReference type="GeneID" id="110979414"/>
    <dbReference type="KEGG" id="aplc:110979414"/>
    <dbReference type="OMA" id="TEMQADV"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665548" evidence="3">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022090879.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="24446" checksum="2E49DEDB6AEDF473" modified="2022-01-19" version="1">MGKSALQLIAVLVLLVPEIIAQPPVAAPGSTSTEVSVVSTSAPTDTTTNSAYTATNTASSPDGIITTTDGDVTANSAKTASEPTGDVTTKDTTTTAGAPNDATTLVSDTVAGGNPPTTDSPDGTTSAEDVTTVILSTTNAAELSTATATDVSTTTATDESTANATDESTANATDLSTAFVADASTNAADPSTTVTEPEHTAIATLPSQGPIPLSAGAIAGIVIGVAASVILGGVVIGVVVVKCKAAGSAVAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCE8</accession>
    <name>A0A8B7YCE8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Etoposide-induced protein 2.4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EI24 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090929.1">
        <property type="nucleotide sequence ID" value="XM_022235237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCE8"/>
    <dbReference type="GeneID" id="110979438"/>
    <dbReference type="KEGG" id="aplc:110979438"/>
    <dbReference type="CTD" id="9538"/>
    <dbReference type="OMA" id="HMCLLYA"/>
    <dbReference type="OrthoDB" id="266518at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022090929.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="36232" checksum="C7CD7520B9E7DF62" modified="2022-01-19" version="1">MTDSVKLILGDVCCGMRDAVLGALFIFRVDAEINALAEERRRKREEKMRESQRRPIPLKEKKESEPKVMHRMLQCCLLNGGVFWLSIVTFNNLVLPALQFVTQKIIGISGQSISNSTVWAWVGPMMSYTFSALWVLPLFVLSKAVSGLWFQDIADAAYRKSRGRPQLPNLSELIADLLFSLLIQALFLMQSMVVSLIPIVGVGQFLSLLHLCLLYSLYAFEYKWFNMGWKVHRRLAIIEFNWPYFFGFGLPLALLTSLPSSYLIRGCVFSILFPLFIISGNEAATPTQPCSFPLHIFSLVVEIANKMFHRTVKRPTAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCG0</accession>
    <name>A0A8B7YCG0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cholesterol 24-hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110979450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090938.1">
        <property type="nucleotide sequence ID" value="XM_022235246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCG0"/>
    <dbReference type="GeneID" id="110979450"/>
    <dbReference type="KEGG" id="aplc:110979450"/>
    <dbReference type="OMA" id="FLMWCIP"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033781">
        <property type="term" value="F:cholesterol 24-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006707">
        <property type="term" value="P:cholesterol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10442">
        <property type="entry name" value="GIY-YIG_PLEs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039983">
        <property type="entry name" value="CYP46A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293:SF0">
        <property type="entry name" value="CYP46A1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 46 SUBFAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="4">
        <location>
            <begin position="216"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022090938.1"/>
        </source>
    </evidence>
    <sequence length="640" mass="73731" checksum="DA7C8A4A1831EE73" modified="2022-01-19" version="1">MLKYGKVYKMFIFQKPIVVVLEPSFLKEVMHSTTHSKPAVEHANFWHVFGSRCFYHGLLTETDVPKYLKRRALFNPAFHRRVCCKSVLGDGGSVGGGDIGEQGDDIKADHDVVWLEGEVLDEGSKLVRVLDVMFGVPHQGQKNFGEGFMDLQADLISCGLVKVAEDRFGVLDAVFSITSHHIQRILHKQGIRVFHTAPLQLHNLFTSHKDRQDPQRRPGVYRIPCQCGKVYIGETGRDLPTRINEHKTHGRKGELEKSSIIKHSHTEDHQINWSQAELVTSIERWYLMQSMDAFNDSVDLLIRKLSKDANGKTEVKMLDVFNKITLDVVAKVAFGLELDDVMEKDSPFTQAILMTLLGIQSQFFEPWRRFSPLSSDRKFRQDVRQAIKYVRATGRRCIEARLEAKRRGEKLPRDLLTYILEASRDFQADSDFNIEEMIDEFFTFFFAGQETTANLMAFILVELGHNPEIYQRVMTEVNAVFGDKERIEYSDLGKLEYLSMVIKETLRLWPPAFGTNREMACDMTVLGYKIPQGTVVWLNTYVMGRVEEFFKNPLVFDPERFCKTEKGEREKNLFTYFPFSMGTRACIGQSFALIEARLIIGRLLHNFKFTLAPGQRRDDILQEITIKPRQRCTNYLTPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YD24</accession>
    <name>A0A8B7YD24_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110979563 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091159.1">
        <property type="nucleotide sequence ID" value="XM_022235467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YD24"/>
    <dbReference type="GeneID" id="110979563"/>
    <dbReference type="KEGG" id="aplc:110979563"/>
    <dbReference type="OMA" id="VILLEWG"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10336">
        <property type="entry name" value="SLC6sbd_Tyt1-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047218">
        <property type="entry name" value="YocR/YhdH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42948:SF1">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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        <location>
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            <end position="550"/>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDM2</accession>
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        <submittedName>
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        <name evidence="12" type="primary">LOC110978783</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
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        <scope>IDENTIFICATION</scope>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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</entry>
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    <accession>A0A8B7YEL1</accession>
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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            <end position="79"/>
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            <end position="278"/>
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            <end position="311"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFE1</accession>
    <name>A0A8B7YFE1_ACAPL</name>
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        <recommendedName>
            <fullName evidence="6">Programmed cell death protein 5</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9" type="primary">LOC110980009</name>
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    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May function in the process of apoptosis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091948.1">
        <property type="nucleotide sequence ID" value="XM_022236256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFE1"/>
    <dbReference type="GeneID" id="110980009"/>
    <dbReference type="KEGG" id="aplc:110980009"/>
    <dbReference type="OMA" id="MQYEMQK"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.140:FF:000001">
        <property type="entry name" value="Programmed cell death protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003268">
        <property type="entry name" value="PRK04239.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00056824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00071574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091948.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14707" checksum="71624104780B6451" modified="2022-01-19" version="1">MADSDLEEIRARRLAELQQQYGEQDPNARKEQEAAQKRKEDMINSILTQVLDQNARARLNSIALVKPEKAKMVEMMLIQMAQTGQLPGRIGEDQLKGLLEKVSMQTQRKTKINFDRRRVMDSDDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YG25</accession>
    <name>A0A8B7YG25_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G1/S-specific cyclin-E-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110980132</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin E subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092193.1">
        <property type="nucleotide sequence ID" value="XM_022236501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YG25"/>
    <dbReference type="GeneID" id="110980132"/>
    <dbReference type="KEGG" id="aplc:110980132"/>
    <dbReference type="CTD" id="898"/>
    <dbReference type="OMA" id="WPPTISG"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20519">
        <property type="entry name" value="CYCLIN_CCNE_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20520">
        <property type="entry name" value="CYCLIN_CCNE_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000024">
        <property type="entry name" value="G1/S-specific cyclin-E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 8" id="KW-0195">Cyclin</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="10">
        <location>
            <begin position="160"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="11">
        <location>
            <begin position="254"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022092193.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="48830" checksum="75419A2995B10ECB" modified="2022-01-19" version="1">MSRRRSNRLQTRQESLLPAQESEGEFTICSRKRKIREDDVDDELHSAEIQRRRQQFQIQNSWVPISESGGFETSSLIPTPHQEPTTPSEQLLESGSKFRFRNLFPTPLTDRRSPLPILNWADSTEVWQVMLEKESNYIHNTRVLDRHPSLEPRMRAILLDWLIEVCEVYRLHRETFYLAADFVDRYLSKTSNIPKTKLQLIGITALFIAAKLEEIYPPKLAEFAYVTDGASTEPEILDQELVMLKTLKWGLSPVTVNTWLNIYLQLSRRSHTTRSSHNFLLPEYSGHQFVQIAQLLDLCILDIGCLQFDYSVIAASALYHMTSQELALEVTGLKWDDIATCVHWMSAFAITVREMGLAELTGFRSVYSDDAHNIQTHANQLSSLDRALDRLQQIMQPLDSSPIHMAGVLTPPHSHHKGYTQTVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH79</accession>
    <name>A0A8B7YH79_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chromodomain Y-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110980005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091937.1">
        <property type="nucleotide sequence ID" value="XM_022236245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH79"/>
    <dbReference type="GeneID" id="110980005"/>
    <dbReference type="KEGG" id="aplc:110980005"/>
    <dbReference type="OrthoDB" id="409763at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF11">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="691"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="783"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="607"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022091937.1"/>
        </source>
    </evidence>
    <sequence length="911" mass="99784" checksum="131D5AA46DA0B54B" modified="2022-01-19" version="1">MAHSNGTEDFEVTKIVKQRRNKKGKLEYLVRWKNYGCEDDTWEPVENLRNCMDLLDAFSERNLREKGPFWKGSPPHKKPNSSKQRDPSRAKRDSKSHMTCMRTDWEVCQNSRAPAKRKNPFQDACQVVLKKERMFPNGDQHYTCNGVSDPSPSSVSSTSGSSSTDIKLSSLTNNKHFHRPRSMSCMGYENPEASVDDIKGSESAKRRRVNSLLDIGNSDLLNTGKSLDTPTTTPPSTPTNSDAQLALTPLLTPIVKLHDLKAGGSFKLPSPKSLLSTEKFIRARLSRKDREDKYAENFAPRRFSQSSVSSEEEDETKRRFSTRQCDNIFKYKEIVVKKHPGYTQVWFFTNSPARNALNVKALQELTDVLEKSTKDETKALLLTGSGNIFCTGLDLEKLLVTEQRRRHAKKLAEALRVFINALINYPKVIVAAVNGKAVGLGAAILPLCDIVYSSDKAEFHLPYAAMGQPPEGCSSFTFPNAMGLPVACDLLYSGRRMTALEACASGLVSQVLWPTSFMSEVIPRVKVIANSSCKTRAGTPPGSGKDPVSLVNRWPGKPAKTPEGVPQVDIFRARLTIIARHAFQPPMAQRNPCGVPASTPLATPKNTSRSSSATKTTSPAVSARTPRYRSHWVGLPTNARTHPAWCTTEPRYPAAWQFLSSPMEPLGLLRRRGFKPLKPIQGSGFQLGITGSSDLISPGPSARNSTVPADLDRERSLGVPPPTASSTVSVVRSPATGKCKHSPSSSSSSKSKKRHCFDQGPNSEQWMSAFLSINEALTSIACRLDDRPPPAPTAPDPFLADQTLPPPSAASQYDTGQGFTPDSQQQGVSEPSERAVFNEGTRALERVTALSPTAQPAFSSDEDEVGSVDTLALFEGHLQLLQQDMIQVLGLPSAIPLEEDASHGLFKCHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJK8</accession>
    <name>A0A8B7YJK8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Rhodopsin, GQ-coupled-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110980438</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092807.1">
        <property type="nucleotide sequence ID" value="XM_022237115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJK8"/>
    <dbReference type="GeneID" id="110980438"/>
    <dbReference type="KEGG" id="aplc:110980438"/>
    <dbReference type="CTD" id="94233"/>
    <dbReference type="OrthoDB" id="9996086at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050125">
        <property type="entry name" value="GPCR_opsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002962">
        <property type="entry name" value="Peropsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027430">
        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01244">
        <property type="entry name" value="PEROPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00238">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0157">Chromophore</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="108"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="412"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022092807.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="61676" checksum="3FCBCA32683CB741" modified="2022-01-19" version="1">MITLQCVYIPPIKAAPIKLPCYSTHREQTDSATGLTHRTEKSVFVRSSSSKITDTAAEMENTSWNSVSDFPLMGTTAPMPRGPPPMPPFLDYGLAFFLFVAFVFGIAGNGVTLWIFVRTKSLRTAPNMLIVNLAFSDISMIITNFPLMFASTIYGKWLFGDLVCEIYAFFGGLFGFMSIATMTAIALDRHAILFNRHYVICHSMEAMRTVTRRKAAYKILLVWIYSSIWSLLPFFGFGAYVLEGYGVSCTFEYLDLSLKNRLYVGTIFTFGFLIPLGVIIACYVHIAYTLRQHRLQLMRVQNDLRSPGNDKAQAAAIRKVKAENVEWQIAKVGIMLTILFCASWMPYASVAFIGEFIDASKVTPMVQVIPVVLAKSSASWNPLVYAISHQRFKEALRDHFFVYCCGESQSRRQRHSTTRSMSSENRNTDSRATSVRSVISEADKRDRTGTVMSTVSTKTDEIEMESGVQKPTRSSLKGGRERANKNSNNNGNQSASEQRRRSFPDTSSTTVDSGNVNLVMKSRDGVKIQEHYAAYDNPAASVSDREELTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJS2</accession>
    <name>A0A8B7YJS2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPRY domain-containing SOCS box protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091816.1">
        <property type="nucleotide sequence ID" value="XM_022236124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJS2"/>
    <dbReference type="GeneID" id="110979931"/>
    <dbReference type="KEGG" id="aplc:110979931"/>
    <dbReference type="OMA" id="WTWNKRD"/>
    <dbReference type="OrthoDB" id="5951542at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12876">
        <property type="entry name" value="SPRY_SOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000078">
        <property type="entry name" value="GD12021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035754">
        <property type="entry name" value="SPRY_SPSB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF12">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091816.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27745" checksum="EC0F3DD1181CA274" modified="2022-01-19" version="1">MAAAPPLLHEGCEDFWSWSANDKSHEVKLQGARNETAVFHPNWSNGTAGVRGTRVLNRGRFYWELKLSHRVFGTSMMFGIGTRRTRLHVDEFVNMLGENDQSWGLSHKGLLWHGGTSRPFTDPFPEKQPTTLGLLFDGIKGTLTYYKDGVCLGEAFTGLNRYTSELYPFVCSTAAKTEMTLTNMRRGMVSLEDRCCVTIATHLRSEKEAGGLLLPAILRSNIARECSRQSQNNDPLTHLKSSCGVTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLA8</accession>
    <name>A0A8B7YLA8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 T</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">E2 ubiquitin-conjugating enzyme T</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein T</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase T</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110981114</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022094048.1">
        <property type="nucleotide sequence ID" value="XM_022238356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLA8"/>
    <dbReference type="GeneID" id="110981114"/>
    <dbReference type="KEGG" id="aplc:110981114"/>
    <dbReference type="CTD" id="29089"/>
    <dbReference type="OMA" id="GVEKKFC"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23805">
        <property type="entry name" value="UBCc_UBE2T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000041">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="13">
        <location>
            <begin position="2"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="145"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022094048.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="25209" checksum="7230736481C02AA3" modified="2022-01-19" version="1">MRRSLRIGKELSQLEREPPPGVSCWMKDENTNQLQAQIIGDEKTPYSDGVFKLEIQVPERYPMEPPKVRFLTPIYHPNIDTAGRICLDLLKMPPSGSWKPSLSISTLLTSIRLLVSQPNPDDPLMADISAEFLRNRDLFEQKARDHTRNHAMQKTTAVNPPNQAKNQSDSDESDQSDSSSDEMDQSDSSSDEGKPSRGQLAAQKRPTEEGRTAQPEAKKLKSSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLK6</accession>
    <name>A0A8B7YLK6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110980825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110980825</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093521.1">
        <property type="nucleotide sequence ID" value="XM_022237829.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093522.1">
        <property type="nucleotide sequence ID" value="XM_022237830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLK6"/>
    <dbReference type="GeneID" id="110980825"/>
    <dbReference type="KEGG" id="aplc:110980825"/>
    <dbReference type="OMA" id="AMARHYK"/>
    <dbReference type="OrthoDB" id="10103160at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093522.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23665" checksum="830E81E82209DF0A" modified="2022-01-19" version="1">MSLKDSILQSLRPTPKRLYESSVCLASCLKNHEEAKGPGTKTDHDGVSSGSASEPTEKPTLAAMARHYKLGQLLRSLAPLIVVQERLYRRLEERPDVNAAARKTFPELFQVMDIESRTILKISSDFSVEKEDRYAMEANLNLLRESVVRITEALQTVREAQYESPGRLNNKLADTVDALRVDWHAVQSIRASLPERYPLDYEQLHEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMM5</accession>
    <name>A0A8B7YMM5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Interleukin-17D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110980396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IL-17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092726.1">
        <property type="nucleotide sequence ID" value="XM_022237034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMM5"/>
    <dbReference type="GeneID" id="110980396"/>
    <dbReference type="KEGG" id="aplc:110980396"/>
    <dbReference type="OMA" id="MSSESKW"/>
    <dbReference type="OrthoDB" id="6038945at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020440">
        <property type="entry name" value="IL-17_chr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010345">
        <property type="entry name" value="IL-17_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06083">
        <property type="entry name" value="IL17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01932">
        <property type="entry name" value="INTRLEUKIN17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034885123" evidence="6">
        <location>
            <begin position="20"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022092726.1"/>
        </source>
    </evidence>
    <sequence length="196" mass="21345" checksum="E728374B4866A384" modified="2022-01-19" version="1">MAMSISTLFCLAMPSLVQALPLATPVSTPPGCSGSVVEVHVLSTIDARLFGLLSYNTSGLQPLQSVHVPVQEDHEPDSEAHCPSSLEPVQQMWGPSRASTCPWIYQHDHDPNRYPSELAWAVCQCQGCLSREGGAKNEIPDMECRQVKYRMPILRRNGCSGGLVKYNLDWLEVPVACACMRPETPTGNRPPGIMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN33</accession>
    <name>A0A8B7YN33_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="10">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110981022</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093860.1">
        <property type="nucleotide sequence ID" value="XM_022238168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN33"/>
    <dbReference type="GeneID" id="110981022"/>
    <dbReference type="KEGG" id="aplc:110981022"/>
    <dbReference type="CTD" id="83939"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000149">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 10" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="13">
        <location>
            <begin position="221"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="436"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="542"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022093860.1"/>
        </source>
    </evidence>
    <sequence length="594" mass="65923" checksum="72B00B9CC567A48E" modified="2022-01-19" version="1">MTDFKMAAPRPQVALRGKEGLWMVHGPPDFRENAQFPRDSSVACRVMAYSPDGTLFAWCNGQSTTVIRVADWVVVQQIPTNRTAQLGFSPRGTYLATWQQYHAIKDNPAASYNLHIWNLETGKSVKATIQKKRALWRPQWTSEESVCAVFASGGVHFYRDHDFENITARLTLPRMEGCVLSEGEAPPTVGAYVPVIKGTPAFVRLYRYPNLGGEGSALASRSFFKADSIHMLWNKKGTALLAMASTDEDKTGQSYYGEQSLHFLETNGEGCAVTLPKKGPIYSIDWNPNSMDFCVVYGFSPAKATLFNLKCEPIYDFGTGPRNCVYYNPQGTVLCLAGFGNLRGKMEFWGRGSLKLVSRMQADDSTQFEWSPDGEHFLTATCAPRLRVGNGYKFWHYSGRLLNEFSVPRDKELWEAVWQPFPAGTFPAKPIISPQVAATQAEPKPAPYRPPNATGASTVKFREEEAPEAVSDKALSKNALKNKKKREAKAKAKKEELVGSPLDPRSAEQRDALAMASYVLGPAQNTPVTPPSLQDATIPTEIDKKIKNLRKKLKAIEKLKEQKAEGKTLEANQLSKIEGEAVIIQELQELELNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN87</accession>
    <name>A0A8B7YN87_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Y+L amino acid transporter 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110981141</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094126.1">
        <property type="nucleotide sequence ID" value="XM_022238434.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094127.1">
        <property type="nucleotide sequence ID" value="XM_022238435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN87"/>
    <dbReference type="GeneID" id="110981141"/>
    <dbReference type="KEGG" id="aplc:110981141"/>
    <dbReference type="OMA" id="FVLVCTC"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022094126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022094127.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="53860" checksum="59B536FC15ACDBAC" modified="2022-01-19" version="1">MEEEQTSQAVEEGDKHGQEADSERQIAPSASPDIKLKKKIGPLVGVAIVVGVMMGSGIFISPSFVLASSGSVGVALLVWTLTGLLSIIGSLCYMELGTMILMSGGDYAYIHFAFGPLPAFLYVWVTTVIGAPTMLAIMTSAFSNYVLYPFFQGGQACSPPPSSLYLLGAVCLLLVMFLNIYSVKWVARAQGVCTALVILALLVIIISGMVKLAQGNTAAFVNGFETIHGLSTAPGSVAIAFYAAFFAYGGWNILNFLIEELTNPVRDLPIVLMVSLPLVTIINVLVNIAYLAVLKPQEMLESKAVAFTFGNKVLGDAAWIMPIAVAISMVGAVNAGLLKGSRTCMVGARKGQFPSILGMIQVQRKTPAPALLFVSSFGLIFLTSNDIGRLINCFSLVTWATILASISGLLYLRWRRPELKRPFKVNLVLPIIFVLVCTCLIVLGFISAPWDSLIGVGMTLTALPVYALCIYPANKPSWLRKISYAVTVFLQKALFVGQEDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNI4</accession>
    <name>A0A8B7YNI4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110980537 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093016.1">
        <property type="nucleotide sequence ID" value="XM_022237324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNI4"/>
    <dbReference type="GeneID" id="110980537"/>
    <dbReference type="KEGG" id="aplc:110980537"/>
    <dbReference type="OMA" id="CHIVKEG"/>
    <dbReference type="OrthoDB" id="10436972at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049341">
        <property type="entry name" value="TRADD-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20694">
        <property type="entry name" value="TRADD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRADD-like N-terminal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093016.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30193" checksum="5C0904D93C2A9FD1" modified="2022-01-19" version="1">MVALSCPENDLKSVTECTADMETSLSPNLSVNEKDISRMGLVSGLINNEKITPDDKKTSSDFPSSISGDLPRCISFDCGNIKCYNYGMSTKFKLIKNGMELKDVTRNAFRLMHEMVTQHGRSHLVGLLSDVFTACDALLDRVQLGCVKFVLRFNTREGLQKLWDMYSSGELAERMTRALVTDELVPGDKTDIAVLPSIDQSDFEAGMKFFDELEQAEKEVAEEERRQFKTEKVTLPEDQGSVGSDQNQPGTSEMSKEQAADTAEDPMDNSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNK8</accession>
    <name>A0A8B7YNK8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110981107 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094035.1">
        <property type="nucleotide sequence ID" value="XM_022238343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNK8"/>
    <dbReference type="GeneID" id="110981107"/>
    <dbReference type="KEGG" id="aplc:110981107"/>
    <dbReference type="OMA" id="CCWCADE"/>
    <dbReference type="OrthoDB" id="10439536at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094035.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="53737" checksum="62AE5EAB2A2EF2B0" modified="2022-01-19" version="1">MFPKRTAPEVPEKKETTVYVFGEKDAQVALSRASRTEVKRAAICACAVVVTTLILVAGTLGAIALWLSFHHTPHDGHHVAHYDGDRDEKPLSPGIEIDDGGLWPVGDIGQVDVTESITEVPGAATGAGDILIDGNDRGFGQSETTTATPKAEQTTGTTPSASPHPESSVWDSFSVPYSVLSEQDLGASSDYGTISFTWDSASDAGSGSGSDTDGEDYEEIPYRSSATSYYSSSFVGESYDPITNLGVYEGRDDWYWEDDASGSGSGDTETSGDGIVPAVVDPYSLGQETARPVPKTPQEFTVVRYPVPVSNYNTLCTSVSSWNTCAFGFFKREDRMEVIETDLRMKPLRLTVLRKNGGRIFTMTRDEDQGYRAILLDESGICLLTRLDNTENLHIRQNSAVPIVEKLRVTLPVELPVPLLSQISGPIMDTCRNVPVFWAQQVGDSDEANFITRMRRSSPPSAAGSTDGGVDLGGGIHFQCCWCAYADDPCPCECGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQ36</accession>
    <name>A0A8B7YQ36_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nose resistant to fluoxetine protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094565.1">
        <property type="nucleotide sequence ID" value="XM_022238873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQ36"/>
    <dbReference type="GeneID" id="110981359"/>
    <dbReference type="KEGG" id="aplc:110981359"/>
    <dbReference type="OMA" id="INDSPMH"/>
    <dbReference type="OrthoDB" id="118951at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006621">
        <property type="entry name" value="Nose-resist-to-fluoxetine_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052728">
        <property type="entry name" value="O2_lipid_transport_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161">
        <property type="entry name" value="O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11161:SF0">
        <property type="entry name" value="O-ACYLTRANSFERASE LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20146">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00703">
        <property type="entry name" value="NRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034448782" evidence="2">
        <location>
            <begin position="22"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="574"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="608"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="680"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Nose resistant-to-fluoxetine protein N-terminal" evidence="3">
        <location>
            <begin position="57"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022094565.1"/>
        </source>
    </evidence>
    <sequence length="771" mass="86043" checksum="AFDC9B8DE44CB430" modified="2022-01-19" version="1">MATSTARFVFISVLLLTICCAISFAHLEVDPSKLKNILYKSWSPPLHEATVDTYNVSAACEAEIKRLIGGDPRTLESDVIMALDAFGKPPAGLLQLNFGWYGHYDECMAIEGFNYCLTDLMLNVTKLSEHPKNSSLGTGFPGMETMDIKWGICVPKNCSDEDVDAVITHLLDALQVLESVNIPRDVLQETGVVCAKNPTIPYSAGVICTIILCGFIGALMILGALYDEFLKLQAKKSIHHRLREGMRQPWRLLDETDEADVADDDVPLLKDVGTGNSINRESPSPKTQSLAARLLLCFALNRNVAKLMDTKQSDASVGCLNGVRVISMSWVILGHTVAFSVLNPIDNLPTFYHWISTHPGFQAVANAFFSVDSFFFLSGFLVAYLTFARFRELRTIKTWALFYFHRYWRLTPLFAFTILIWMYIPQYFGYGPAWQSSAFREFCPQYWWSSLLYISNFWPKAFGEECIAWTWYLANDMQFFAISPLLMAPLFYFPLFGWLALIATLLASFISTGLIIGLYDLQVSLAGLESGPPDANFSSLVYGKPYCRIAPYLVGIGLGYIMHRIGKRRVKMSPVLAVLGWLVAAGMALSVLYGLYPSFHTPMTKAANIVYGSISRFVWALALAWLVFACKYGYGGWINSFLSWSVWVPLARVTFSAYMFHPIVIEVFYGNFASPFHFSVYLMAFYFAGLVSVSYFVAILVALAIEYPFANLEKVLLPTPARTKKVEGLDGRATMAGDREVVTVVTGRPVENGLTQRVSAYQKGLADSRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQR7</accession>
    <name>A0A8B7YQR7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110981618</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022095017.1">
        <property type="nucleotide sequence ID" value="XM_022239325.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981618"/>
    <dbReference type="KEGG" id="aplc:110981618"/>
    <dbReference type="OrthoDB" id="18487at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000102">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF560">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="589"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="817"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="1135"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="1307"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1038"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1080"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022095017.1"/>
        </source>
    </evidence>
    <sequence length="1408" mass="154419" checksum="AE522380D0702F94" modified="2022-01-19" version="1">MTSFLKIAPHAFRLEDAVVRAGFNSNHLLNPEIGRVSSDQANSRAVVDFTPEPYVTARYVSVSIIRSGADAIVQLTEVMVEEGTTKLKDALPTALNLAARPSSQISSFTDQSGIWDADRAVDGVLQYVSPYCSRTNVEQNPWWKIDLTSFHCISKIAIRNIDDLEQTTRLNLEHAVARAGLSATSTGNAMCGSPVTQYQALINDWIEFVCDPSRLARYVSINIPGEAALILCEVIVLQCDLQPQALNMTEKPTNQSSTINGQDAGRAFDGLPEEPFCSVTDNEENPWWRVDLESSYCLGIIQVRNTGSPTEPNLQDAVVRAGLNEVHTNNIMCGTPVTSDQSVINDWIEFACDPPVLARYVSVDIPGTTIFKLCEVTVSTCDFHQRANAVEFTVVANPAVLGDIGHNDSSITAYKGAGDTTSGVLFGRQLPTGGTSNDPPSGSVVLADPSTGCADKLVLRLPGEDGLNRTGVFFSEMISDDITTRVQVVILNKGNNIHVRPVQRTQTANIGESVMLQMHDVNSPSTDYRWRHNGGDIIEPWNNLLNVSIPNVAVESEGIYACFALGQEHKQLHGVMRLIVRGCPSGLWDPPSCLRTCPRCYNGGVCNDKSGTCVCPPGFSGNSCEQAHGRHVFGKMADQRCSPSTDAHHDACRGRLFCLPDPYGCSCAAGYKGLDCMQDCNDGTFGADCKQTCHCAAGGTCSKDTGECSMGCMASYLGSNCQCSTQNGVIGLEVTSGDPHQLFVTWQPDPCAFGYEFTTRDECEDIISQELISENGYHFVSGLASPLSHRVYIRPMYSDDERGPEVTFPRITKPTLAPVDVNLNSATPYSLSFSWSKPPCGSRGGIIIGYTYKLTEVSPESQAVIQSVTSEESVTFEDLTPLTEYSFQVAANTIAGAGPRSQAEVETTLRFPASSSLAWGAAVAVVILILLAVIVVIVVYKRRSHAQRGHSNVRGDTPSQKTKRTLELDVSYQVPKPTQQPAPYACLGDGVISIQTQIKVNGARPDTSQTSESDPSAYAIINDTLAEKSTSGVAALSLKPKHHQKPAALPQPAAEDDTYEVPESGACSCIVAGEFEMPSAPSDEPYLVPSTSQPAREGDSREQWKQQSDSQISAVDIDKLAEYIHRKERAGQNGFPADFKTLPDGQLHPATAAMKPHNKAKNFSVGLFAYDHSRVVLEPLESDPHSDYINASYVDAYSEKDKYIATQGPTESTVDDFWRMVWQLNVDKIIMLTNLKESFQQYWPHSGFTNYSDTALRIIKEEHFADYTIRVFKINKFFSAEGNRLVTQFHFNAWLGMKPPEYPSILLNFMRMVNTEPTEGRTIVHCSNGIGRTGTYIALDSMLDQMQKERRVDVLGFIYRMRQKRINMVQTLEQYRFIFDALLEVSKAGEAEYVNIKKGAKKRGNRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRA4</accession>
    <name>A0A8B7YRA4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">RING finger and transmembrane domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110982010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095814.1">
        <property type="nucleotide sequence ID" value="XM_022240122.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095815.1">
        <property type="nucleotide sequence ID" value="XM_022240123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRA4"/>
    <dbReference type="GeneID" id="110982010"/>
    <dbReference type="KEGG" id="aplc:110982010"/>
    <dbReference type="OMA" id="VELHCKH"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044235">
        <property type="entry name" value="RNFT1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860:SF0">
        <property type="entry name" value="LP20373P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860">
        <property type="entry name" value="UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="317"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022095814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022095815.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42457" checksum="499CB23B819C41B8" modified="2022-01-19" version="1">MASAGEQRPLTDRLENVLQGFIPGLATMEDPARPVAVGQGRDAIIIDMPAATSPAEENRNGAGSPSEGASAEGGDGDNGERPGGIPDGHLRALRPLMERTLPFVLILLLKILYDHRLGVLVLIGMGAAFFHFNSKIKEQIAQRDKRSLRSLLFMFLLLPVNVVLVYYVFADQQLPKCLIFLKPNFEKTDFWTLLWVIGITDYVIKYITMATKCLVTALPRVCLSFKRRGRLFLCIESISQFYRFLTPVPIWMAFLSEGTDSHWLFSYALVLLYLMVKACITYSKMFECFATVRNVLKDSQYGSRPSSEQIQVVGEACPICQDNFNNPVELHCKHIFCEECVTMWFDRERTCPMCRAKVADSPQWRDGSTTGIIQWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSN7</accession>
    <name>A0A8B7YSN7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">sphingolipid 4-desaturase</fullName>
            <ecNumber evidence="3">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110981957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022095712.1">
        <property type="nucleotide sequence ID" value="XM_022240020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSN7"/>
    <dbReference type="GeneID" id="110981957"/>
    <dbReference type="KEGG" id="aplc:110981957"/>
    <dbReference type="OMA" id="GATCNQN"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022095712.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="39010" checksum="2A4A04DA4D67EE98" modified="2022-01-19" version="1">MGLSVSKSDFAWVYTDEPHFTRRKEMLKKYPEIKRLMGHDVNIAYIMVIMVIFQVTTAYLLKDQAWTTIFVVAYCFGGVVNHAMSLALHEVGHNLAFGHSRPMWNRVIGFIGNCIIGVPVSVSFKRYHQDHHRYQGEESLDPDLPSEWEGYLFRNAPTKAIWMLLQPFFYAFRPMLRRPKAPTRLEVINYAVQIVFNAAIIYFFNLKAYLYLLIGTITVMGIHPMAGHFVSEHYLFKEGHETYSYYGPYNYIAFNVGYHMEHHDFPNIPGNKLPLLRKIAPDYYDVLPTHDSFAMVVWNFIFNPSFGPYARYKRPDSMDPKNIDAWEKYMYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTY3</accession>
    <name>A0A8B7YTY3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LYR motif-containing protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096157.1">
        <property type="nucleotide sequence ID" value="XM_022240465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTY3"/>
    <dbReference type="GeneID" id="110982205"/>
    <dbReference type="KEGG" id="aplc:110982205"/>
    <dbReference type="OMA" id="YTTDKLV"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
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    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096157.1"/>
        </source>
    </evidence>
    <sequence length="95" mass="11064" checksum="8C90F388FBD06702" modified="2022-01-19" version="1">MAATMASATRSTVLKLYRQILRESKKFTGYNYREYALRRTKDAFRENKSLTDEAGINALIREAEENLQIIKRQVVLSQLYKDPLLVIEENKPGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZU0</accession>
    <name>A0A8B7YZU0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022096711.1">
        <property type="nucleotide sequence ID" value="XM_022241019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZU0"/>
    <dbReference type="GeneID" id="110982540"/>
    <dbReference type="KEGG" id="aplc:110982540"/>
    <dbReference type="CTD" id="54363"/>
    <dbReference type="OMA" id="RIWFRPK"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF107">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="11">
        <location>
            <begin position="5"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="297"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="320"/>
            <end position="321"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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            <dbReference type="ARBA" id="ARBA00024042"/>
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            <dbReference type="ARBA" id="ARBA00029325"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00029327"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="PIRSR" id="PIRSR000138-2"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022096711.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41335" checksum="3FF41038DF451DD8" modified="2022-01-19" version="1">MSAMAGGRNPVCLKDFEEIARINLPKNAFDYYQSGADAEQTLRDNEAAFRKYRLRPKHLRDVSNRDLRTSILGQEIAFPIAVSPTAMQRMAHPEGEVATARAATSLGTGVILSSWSTSSIEEVAAGCSPIGPRWFQLYVYKDRDVIRDLVRRAEREGYKALFVTVDTPILGRRRADVRNKFALPPHLRLANFDLSRLHSSGVHSSEDSGLAAYVASLIDPSLNWEHIEWLKSITSLPIILKGILTAEDAKLAVEHNVSGILVSNHGARQLDGVLATIDALNEVVQAVRGSNVEVYLDGGVRTGTDVLKALALGARAVFIGRPSLWGLAYNGEAGVREVLELIRDEFKLAMALSGCTCIADITPDLIQKDKFLLMAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1F2</accession>
    <name>A0A8B7Z1F2_ACAPL</name>
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        <submittedName>
            <fullName evidence="5 6 7">G patch domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC110983983</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
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            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
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        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_022243736.1"/>
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        <property type="nucleotide sequence ID" value="XM_022243738.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="412"/>
            <end position="475"/>
        </location>
    </feature>
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        <location>
            <begin position="537"/>
            <end position="583"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="188"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="339"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="47"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50174"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022099428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022099429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022099430.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="64568" checksum="7FDA6A819A1C866B" modified="2022-01-19" version="1">MEKALAAAIETRLSTFRQPENGPQTSTMSSPKFVKRQARKRRGRKRRMDSNPAWEHNVRFSEGSDTSLDEAQKDYMENVAAHQSDSASEDTVMMRRLSSLNVTSSSNLYGESDSVTESHVLPKQTLRRKKRFKRMVVDPTRIPPGGCPPAKIKFSCGADFLPECSRKRHKLKRSRNNPSDNAENASHIDGGKFGFDILGFKSKKRGCAGGSKNRSVSKPSKSDSSPQSPSQVDLATNSDSSVHQRVSTESPVSLPDTSSGTGRKLSGSDAASEKTIGREMECTSNESDVTMDALPSKDRSSCDSDDSLTSSDEGALYTNDEGREGDDEQSDFFQEPDALSGIPGIIPWWEKKTALRMKEDERFSNILNGTIPLLSRSAQRNYQSRLRSLQNGEDGQLRGCRPRIHKTKRLKRTSLSSVNEKIVGFLRNPHEKELLFQPMKKKERTQLGQLASLYSLDMRTEGARCKRSPVLVKTRNSTMGDPNLEEALGLVSLSVDRISPGRKSLCPQFVDAKRRRKTPPPTITEGQVGRSAGPIPQSNLGCQMLQSMGWVPGTGLGADGGGIQEPIKAYVRPKNRGLGYWKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5Y3</accession>
    <name>A0A8B7Z5Y3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100367.1">
        <property type="nucleotide sequence ID" value="XM_022244675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5Y3"/>
    <dbReference type="GeneID" id="110984459"/>
    <dbReference type="KEGG" id="aplc:110984459"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034923865" evidence="1">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100367.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13263" checksum="604A585804A62BD7" modified="2022-01-19" version="1">MNRLLLACALLAVVIASVKADCSPGYTQRIAVDKLWSTSHESWLFADHFCTVEGARLANIRNDADSIWINDFFLKNKRYLCGSGTGLEATILSGRGVDMGGRWQPNDLFQQGKQPASKFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6U0</accession>
    <name>A0A8B7Z6U0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Tripartite motif-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101359.1">
        <property type="nucleotide sequence ID" value="XM_022245667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6U0"/>
    <dbReference type="GeneID" id="110984994"/>
    <dbReference type="KEGG" id="aplc:110984994"/>
    <dbReference type="OMA" id="GINNVCV"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="430"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="6">
        <location>
            <begin position="487"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022101359.1"/>
        </source>
    </evidence>
    <sequence length="877" mass="97508" checksum="DF8BC845B163468B" modified="2022-01-19" version="1">MAQRSLLGMTREVLGELVTCGICFEKYDERTKQAKVLPCFHGFCAECLGKLVRGNSQLQCPVCRREAPVPEGSVQGLPDNFIAKNLKELEHILGRDETTASSLRCGSCRVGGGYAVSFCSHDECVTFLCQSCDQAHHTMLKFDGHVVNSLQELQERPGILLLRPKLHCQQHKHSLSVFCAEERCQQPICLVCATTAHTGHNIISLDQKESEAKEELQNLTQMVQNQTSTVKEILTKIDSEINNTQNRKVEMSSDISRIFRNLQEQLQSRHDDVIADLEKQSEERIEQLHQQAENAELFVSQLETVSLFAERTCEIGNAVELLQTREQIIPRLHELIDHDIDASVAFQPASKTFLSLTRDHDETLKVVEGLLPELGQFHKVVAEVKPTVPDDQVSSDITWNDAFVRCEHTIVIRFEGCENCLPCLKDLQALYSVLDDTSSPETEAEIKKTDDRKTFRIVYTPPTAGQITMAVLFNSKPIPNSPFTINVNPLHPGSTTLSTPDLGRCPPNTAVLDMPYTLTILTFDGSGERVTTGGYEITAFITTASSEQPHSVTDNQDGSYKVTVIPRSTEMHFVQRIGICGYPVIQAPLKISVRDSLPFEDPPGGYKKPSGIGVDNKSESVFVVDTRQDGKIYIFDSEDGSYVSEHELEKYLHRKSSQIAVDHSGKLVLLVSDLKTVFYSYKGCITHKWKCIYDNEKPANLALSKLGHVIIGDSKSHELFIYHSRGVVLRRIQLPKGSLAMGINNVCVDCNQSILVATHSKPNQILRYTVGGRETARLVSPAQTDQLAVAATPEGALIVSVLRGILVMEFGSKEGDVAVVKEFQTDHIFTQLAVVTDGCFVAFDPGEQHLAKYNYLYIPERADAKKQHGEKTSNSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z739</accession>
    <name>A0A8B7Z739_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Phospholipase ABHD3</fullName>
            <ecNumber evidence="3">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Abhydrolase domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36 37" type="primary">LOC110985051</name>
    </gene>
    <organism evidence="35 37">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="29">Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54456"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:45240"/>
            <dbReference type="ChEBI" id="CHEBI:64489"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:54457"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2-tetradecanoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54404"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:45240"/>
            <dbReference type="ChEBI" id="CHEBI:131738"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54405"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = nonanedioate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54552"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
            <dbReference type="ChEBI" id="CHEBI:78208"/>
            <dbReference type="ChEBI" id="CHEBI:138269"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:54553"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 5-oxopentanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40483"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16120"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77890"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:40484"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 9-oxononanoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:61042"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77812"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41180"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = glutarate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41159"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:77756"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:41160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = nonanedioate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:78207"/>
            <dbReference type="ChEBI" id="CHEBI:78208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:41389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-octadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:75220"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-octadecanoyl-2-hexanoyl-sn-glycero-3-phosphocholine + H2O = hexanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54464"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138212"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>1-octadecanoyl-2-nonanoyl-sn-glycero-3-phosphocholine + H2O = nonanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54472"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32361"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138214"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:54473"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-octadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + octanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138213"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:54469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine + H2O = pentanoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:31011"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:138211"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54461"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-tetradecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54400"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76085"/>
            <dbReference type="ChEBI" id="CHEBI:86162"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:54401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>1-tetradecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76079"/>
            <dbReference type="ChEBI" id="CHEBI:86102"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 1-tetradecanoyl-sn-glycero-3-phosphocholine + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:64489"/>
            <dbReference type="ChEBI" id="CHEBI:86094"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + tetradecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:76084"/>
            <dbReference type="ChEBI" id="CHEBI:86094"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:54389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022101456.1">
        <property type="nucleotide sequence ID" value="XM_022245764.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101458.1">
        <property type="nucleotide sequence ID" value="XM_022245766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z739"/>
    <dbReference type="GeneID" id="110985051"/>
    <dbReference type="KEGG" id="aplc:110985051"/>
    <dbReference type="OMA" id="GCCRTKI"/>
    <dbReference type="OrthoDB" id="247542at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000079">
        <property type="entry name" value="Abhydrolase domain-containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 33" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 33" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 33" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="33">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="34">
        <location>
            <begin position="121"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="32">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="32">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="32">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00059841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00071303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00082158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="RefSeq" id="XP_022101456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="RefSeq" id="XP_022101458.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="44532" checksum="8F21AB7996AAF467" modified="2022-01-19" version="1">MSFITVLPTLREYSSTYVLLGALGVYVAYYYTKVVQKPQVFGKDGKFMQFIQRHIPMLREPFRPTMWCFTYHLQTIGPILMKFFNSLQYRSEKILLADGGEIVLDWMDNDEDNRYSNATRPTVLLLPGLTGSSQSHYAVNMIKAAKKHGYRCVVFNNRGFGGAEIKTPRTFCAANTEDLEFVIKRIHSSHPDAPVIAVGVSIGGIILFNYLAKVGEDTPLVAAMTISVAWNTMLSTESLEKPVNFILFNRFLAKELTNVLARNVQMFEGHVDIDHAMQSQTIKEFDERFTSKMFGYETVDHYYKDASIHTKVHHIGIPTLCLSAGDDPFAPLETIPISDAKEQSNIAVVVTSHGGHVGFTEGFFPRGNGYMIRLFEQFVDGFFQHGMTEVLSKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7V8</accession>
    <name>A0A8B7Z7V8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC110984728</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7 8 9 10 11 12 13 14 15" type="primary">LOC110984728</name>
    </gene>
    <organism evidence="3 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100870.1">
        <property type="nucleotide sequence ID" value="XM_022245178.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100871.1">
        <property type="nucleotide sequence ID" value="XM_022245179.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100872.1">
        <property type="nucleotide sequence ID" value="XM_022245180.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100873.1">
        <property type="nucleotide sequence ID" value="XM_022245181.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100874.1">
        <property type="nucleotide sequence ID" value="XM_022245182.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100875.1">
        <property type="nucleotide sequence ID" value="XM_022245183.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100876.1">
        <property type="nucleotide sequence ID" value="XM_022245184.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100878.1">
        <property type="nucleotide sequence ID" value="XM_022245186.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100879.1">
        <property type="nucleotide sequence ID" value="XM_022245187.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100880.1">
        <property type="nucleotide sequence ID" value="XM_022245188.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100881.1">
        <property type="nucleotide sequence ID" value="XM_022245189.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100882.1">
        <property type="nucleotide sequence ID" value="XM_022245190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7V8"/>
    <dbReference type="GeneID" id="110984728"/>
    <dbReference type="KEGG" id="aplc:110984728"/>
    <dbReference type="OMA" id="HCTCRVI"/>
    <dbReference type="OrthoDB" id="10108734at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022100872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022100873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022100874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022100875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022100876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022100878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022100879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022100880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022100881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022100882.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33299" checksum="FACB7C992F9D0CB0" modified="2022-01-19" version="1">MMMATEDNSTTVLPPPPNRNGATGQPTSQDQATIPVAASAASLVLVLLAIVLWYFLVRGQLRKKHYEHKRTSSHHSHQSHQGSLRDCNSRHGSLASRCHGTPRASPHNHRKSANGSPRSKRSSRCTCQYEACTCPSVRSSDSPLLMHSPKSNRSSVTECTGTSPFCPHSRKFRLHKFDIHMRDSMDSDYHPDDENMPGPSNSNQNSKACTCSSDVIVNMDALVSSSGSQVNVETSDGRQPVNCDGAAVCSRIKPISQEEFAKHCTCRVIRNPLGNGRNSKRQSLNHSAPALIGSSSDSDFHAAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7Z9</accession>
    <name>A0A8B7Z7Z9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110984840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022101077.1">
        <property type="nucleotide sequence ID" value="XM_022245385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7Z9"/>
    <dbReference type="GeneID" id="110984840"/>
    <dbReference type="KEGG" id="aplc:110984840"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="48"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022101077.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38148" checksum="D2359F69E71197E3" modified="2022-01-19" version="1">MGFTLPCISSALVYVRLGTQQDEVVRLFTNMGLTIVDIRQAEQRIKSYVSETPVMTSRRMDAQAGCNLFFKCELFQRTGSFKFRGAVNFLAKMRETMENGRVPCVVTISSGNFAQGLALASNLLNTKAYVIMPNTAPKCKQNAVKEYGADVILSSPTLQALFKARDQVVQKTGAVYVPSAQHYDVMAGQGTLCTEMIEMIDQKLDAIIVPVSGGGMLAGVLIAAKSLQPGIQVIAAEPEVADDCCKSFVAKRHIKTDSLPFTIADGLRGSIGDLAWPIARDLLDGGITVTEDEIKESTKLVWQCMKLCIEPSAGVGVAAVMSDKFKAAFPDVKNVGIILCGGNIDLDSMKTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z915</accession>
    <name>A0A8B7Z915_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110985440 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102158.1">
        <property type="nucleotide sequence ID" value="XM_022246466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z915"/>
    <dbReference type="GeneID" id="110985440"/>
    <dbReference type="KEGG" id="aplc:110985440"/>
    <dbReference type="OMA" id="YANENKF"/>
    <dbReference type="OrthoDB" id="10557459at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="3">
        <location>
            <begin position="167"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102158.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="34753" checksum="04E34B7068F7CE94" modified="2022-01-19" version="1">MNSRDGRRDGRRSVSSSGRARRGNVAKGNVGRTAPIGSLVISQDGRSKFYPDGGRERPPIRGPARAPSTVGRKTDDVTYVDSKLPFGTQAVYYNTSFGKPADIDTSNVPMRTPLDDDEDNVSDTGVEPPMNPAQAFMRSFIIFGGLAIVVIIVVALAIVLPIALTGATSRATLTGTVELNSTFIAAYDDVTSTQYANLVNSFNTIMNGIFQNNSTYSSDFRETEVTDLTSGASSVRTRVLFSLHFQSGTEFNSLFRNNVYNFLYQRVIEPATPFASLNLVPDSLVITESCGLFCFNGGTLSILNCECQCMSGFSGARCESSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9G4</accession>
    <name>A0A8B7Z9G4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Alpha-1D adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110985535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102308.1">
        <property type="nucleotide sequence ID" value="XM_022246616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9G4"/>
    <dbReference type="GeneID" id="110985535"/>
    <dbReference type="KEGG" id="aplc:110985535"/>
    <dbReference type="OMA" id="YSACGWV"/>
    <dbReference type="OrthoDB" id="10039923at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="47"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022102308.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="40768" checksum="5ACA89DB64BDD7A9" modified="2022-01-19" version="1">MENTTSTDGTGWPTLSTQETFRAYRSYGERQLFAAMYITAAIMGVLGNTFVILAVVLSKRLRTVTNVFVVNLSVSDLISSIFLPWESVAILSLDGWPLPQAYWICVTTSAILHVSYGCSINNLALIAVNRWIGITKSGSTARRIYTRRNIACMVIFSWAFPLVIISIALLTDYGEHGYEPVYSACGWVKANPYTTLLAVIFSVCFFPIQLCVIICCYFSIYRYVLKTSRRMTAYDAPTVSGSIGGSNRAKQQSQWKRKIAVTKNLAYIVLAYVICQCPYFLAVTQQGYEWGMRLTMYSIAILYCNIWINPVIYATSHPHFKEAFSAMVGCKWQNISRSRAHSQRTVSTSTSTRQNGREVTPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9K2</accession>
    <name>A0A8B7Z9K2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110985561</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022102354.1">
        <property type="nucleotide sequence ID" value="XM_022246662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985561"/>
    <dbReference type="KEGG" id="aplc:110985561"/>
    <dbReference type="CTD" id="130507"/>
    <dbReference type="OrthoDB" id="15304at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF39">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="72"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="72"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1138"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="998"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1020"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1138"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022102354.1"/>
        </source>
    </evidence>
    <sequence length="1880" mass="211653" checksum="C87AF633B1EF59F7" modified="2022-01-19" version="1">MKSDKRKVSAQLKTEIIRNTGHHQLHELLDNVLDPRTSLEKSENLEWCRSLIAGGGTFEEFAKNVRQYDNASTCGLVWTSNFVAYRCRTCGISPCMSICADCFHGGDHTDHDFNMFRSQAGGACDCGDPNVMRSTGFCSLHGPDKLKNLTVPADLLPMADAVVPRVVLRFVLYLREIFEKRSEIPMVRINLHEGEPLLGLLHELCNMGGAMRSVMTRALTDQELYKNLNEGSSGCYSQHKHLISQSLEILKSAQTILNVPESPKFLRGNPAVTYPLVSLSFVEELLFWAVIFEFPEKIVTLLLKMLPDNSYKETFTRSFVKFYGRIAMSLASSTTPERLSSRVVHISVQLFSNEDLAIQMTEELQLIHILIVSLQCLLKRTLTDNNLKGSPGNHRTCQVVSCDHQVMQQHCYWPVISDFSNILSHRSVANKFFTDPSLVKMWTNILAMFMCMNLNERELHNHVEFEPHAYSIAFSAEIEACAAPMWQLYVHCKDESTAHFTQALLNACSETITDWLEAADVSKSLDPYQVSFHIPLLRYYALFLSQAITKQGMDINPSKEFLKQLMNFPLQIQALVGEISCGLWVRNGFQIRRQAFTYVQCHFCASMVDLDLFFLQVCACHLDPDFFVQKVFSSFKVLETLTFNLYHSNSHLEPDKESAMLESALSLLVTLLSTRTHVGATDEELLRREMVALLCMHDATHSRLTDQIPEKTGLFSTNENFEPLLAEVATYHDPLSETGSGGLQQGRYSPKPSIWETEFDPVHVLLRAMQKKDFQNAMDRYNAHMKQTGRHSGNSDLWPPFQLLRDPHPALKNLHQVLHCKALHGALFIILYKAVNSQSVSEPVLYLCIALLDMMLQSPPDVIAQKVERFLAKGGRSLNQEQAFKMTPAPAVIQDGDFSAMFSDNQILSNLGHRIHTVEIPSRAMYEKPSTSRQRTVHSTDQLLQQLLEEEVGIVHQNLFGMPPVLQATGDQGGMEEGEEVYVELEGADEEDWVELQDDEEAEEMEVEEGEEFDVDTPTSAGATATESSSGRSSGELLASAGPPRKAAKVSTVLWTPSKLLTIKESMLELLVKLHAKMAGKEGFYTPPSMRTGTESKTEPGGVQVGGGMFYIKRLLDKICALHPASLKQLEEICQLKQQPTSGTQETDAQSTAADRRKKAREAQQKLFAKLAAEQKKFIEKSLETEDPLDISLDADEEGQATGADKASAREIFECVICGQAAPSTADKPIGMVALLQATSVLGHRSQVAEAQSLPTSNSGAVSIKGRCKEVHQQRKADLQSNFDKSSVQMSVNVGWHGGIHIQSCRHYIHLRCHESYIRSLRQQDYQTPQLQVRDKGEYECPLCRQLANFVLPCPPSVEGCVVAGPSPETRGHAAVVAEVTEKLRLNREGFKESLKGIITSIRDVFQHRLLREIRHRSTSLESLLPFDHSEVVDIILCSTARVNLELDLVVRETLLHPPSTCQSSTNRRTCIGTLLEVLSLLLDKSPVGLATKPWSLLTDVKQIRAPSTSRSSGSASEVPLLLRDPVAMLINLVLAMQHPVSKEHFTCMIRALYAPLYIQALSVISCRMPDTERRAWAESGQTCQDHSSQIQMQPLLSQIIKMYSQSTLYEDTESHEQLAICQSVWTLQCIETAIQEYCLPFLRIAALMQHHLFRDELPTCQKQELEFELIVNYLQLCTAPSTGEQQADLYSAQCLHFVCNPSEFLMGWCQDLLAFVRKNRKTAKSLLLYNPVFFPPRLLQLPKNYDAVFQYYREQKCRYCHQVPNRPALCLACGTFICLNGSRAGCQRASIAEHNMSCGAGTVIYLDINSSTVIIVRGERLCYWASVYLDRHGEEDRELKRGKPLYLCLQRYKVLERLWRSHTLNHSCKNWVWRGPHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZA48</accession>
    <name>A0A8B7ZA48_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102544.1">
        <property type="nucleotide sequence ID" value="XM_022246852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZA48"/>
    <dbReference type="GeneID" id="110985665"/>
    <dbReference type="KEGG" id="aplc:110985665"/>
    <dbReference type="OMA" id="MESYNGR"/>
    <dbReference type="OrthoDB" id="10035172at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102544.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39265" checksum="10587509D023EA8F" modified="2022-01-19" version="1">MSTLLALPFAGNSQPHQPALPMDIRGRTTAKEKRKERRDVGDLVAKKRLENIRLHSAHTRHRNGIINAAEKNRLLNTEKQMDLLQRRAAANISRYQHQLRQELYEMEASRRALRHHSVTEVSSEAHTDMKGLAKFAARGRYLYSVRNETRSQKEEMESYNGRLEQATKLLRPARRQSVAAMDNGKNMGSNPSDTYHEIGRRISMARLNSMTEEHFENECPINETEPTTDTPVDEQALPDHSNSLPPPFDMVKLRSELGPDLQKELDSLEIDDGRGTCLIPIHPSPNYEVCPTELNPPTNATKCSPKPPAKLKLPPVQVNRHFILRKPSTKQLLASIAKPTLSTVSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAB3</accession>
    <name>A0A8B7ZAB3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110985286</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101907.1">
        <property type="nucleotide sequence ID" value="XM_022246215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAB3"/>
    <dbReference type="GeneID" id="110985286"/>
    <dbReference type="KEGG" id="aplc:110985286"/>
    <dbReference type="OMA" id="GGNEHIQ"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000004">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="14">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="12">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="12">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="12">
        <location>
            <begin position="281"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="12">
        <location>
            <begin position="323"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022101907.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="57311" checksum="4F3FE76C156C0A20" modified="2022-01-19" version="1">MSIDFNLDGSMGHRIKSFKNKGRDTEEMRRRRNEVTVELRKNKRDETLLKRRNVPTVDGESDEEPVNQISYHELVQKAASNQPAIQLPAVQSARKLLSSDRNPPIDDLIASGILPVLVECLDSQSSALQFEAAWALTNIASGTSKQTMAVVNAHAVPKFVNLLNSDHGNVCEQAVWALGNIIGDGPKCRDICIDAGVVRPLLSFIRPNIPLSFLRNVTWVIVNLCRNKDPPPREETIRELLPALSALIHHTDTNILVDTVWALSYLTDGGNDQIQMVIISGVVPFLVPLLSHKEDKVQTAALRAVGNIVTGTDEQTQVVLSCNALSHFPKLLSHPKEKMNKEAVWFLSNITAGNQQQVQAVINAGLLPEIIRHLDRSDFQTQKEAAWAISNLTISGSKQQVMTLYENNVIPPLCNLLTVKDCQVVQVCLDAILNILKTSGENYQEIATLIEMCGGVDKIENLQNSENNEVYKLAYEIIEHYFSDIDEEDPALAPQVVQQAYEFEANTNIPSDGFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDW4</accession>
    <name>A0A8B7ZDW4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Protein SPEC3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11 12" type="primary">LOC110985018</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101394.1">
        <property type="nucleotide sequence ID" value="XM_022245702.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101396.1">
        <property type="nucleotide sequence ID" value="XM_022245704.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101397.1">
        <property type="nucleotide sequence ID" value="XM_022245705.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101398.1">
        <property type="nucleotide sequence ID" value="XM_022245706.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101399.1">
        <property type="nucleotide sequence ID" value="XM_022245707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDW4"/>
    <dbReference type="GeneID" id="110985018"/>
    <dbReference type="KEGG" id="aplc:110985018"/>
    <dbReference type="OMA" id="QLLTCWI"/>
    <dbReference type="OrthoDB" id="361532at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026673">
        <property type="entry name" value="SPEC3/Stum"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21676:SF6">
        <property type="entry name" value="PROTEIN STUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15795">
        <property type="entry name" value="Spec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022101394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022101396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022101397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022101398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022101399.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="25770" checksum="034704A4EEF2B3B5" modified="2022-01-19" version="1">MVSTRFQLTIQEFKESRRCFFPPRHPQRSGYTGMESTVVNQQQQPVPGQVVTVVVQERKPNACRAAIPSLHIVAAVICLVLNIFLPGIGTIVAGFSVFCCGNPGQSGGGKFGTFCLNFWVGVLQLLTCWIFLIGWVWSIMWGAAFIGLSADYHTPTETTTVVTSTPAAPVAGQAVVMTQQGVYPPGTVHVSPYPAGQVTTDQPQPPHYDVEKQPLEQKELIQSIDASFTAKTGPPPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEV1</accession>
    <name>A0A8B7ZEV1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Exosome complex component RRP41</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exosome component 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA-processing protein 41</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110986078</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the RNA exosome core complex (Exo-9), composed of EXOSC1, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8 and EXOSC9; within the complex interacts with EXOSC2, EXOSC7 and EXOSC9. The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with DDX60. Interacts with DIS3; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103385.1">
        <property type="nucleotide sequence ID" value="XM_022247693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEV1"/>
    <dbReference type="GeneID" id="110986078"/>
    <dbReference type="KEGG" id="aplc:110986078"/>
    <dbReference type="CTD" id="54512"/>
    <dbReference type="OMA" id="RYNMAPF"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000010">
        <property type="entry name" value="Exosome complex component RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="14">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="15">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022103385.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27045" checksum="7C93C3E3BBF10D5B" modified="2022-01-19" version="1">MAGIELLSDQGFRVDGRRPHELRKIQCRMGVFRQADGSAYIEQGNTRALATVYGPHEATGGRVKAQHDRVTVNCQYSMATFSTGERKKRPMGDRKSQEMSQNLQRTFEAAIMTQLYPRSQIDIYVQILQADGGNYCACVNAATLAIIDAGIPMRDYLCACSAGFVSDTALVDISYLEESLGGPEMVVALLPKSEQIALFQLNSRLHADHLSKVLDMATKGCKDVYTVLDGAVRDHVSEVTDSMARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEY9</accession>
    <name>A0A8B7ZEY9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DnaJ homolog subfamily C member 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110986187</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103552.1">
        <property type="nucleotide sequence ID" value="XM_022247860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEY9"/>
    <dbReference type="GeneID" id="110986187"/>
    <dbReference type="KEGG" id="aplc:110986187"/>
    <dbReference type="CTD" id="7266"/>
    <dbReference type="OrthoDB" id="765884at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000018">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily C, member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000097">
        <property type="entry name" value="DnaJ homolog subfamily C member 7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="316"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="14">
        <location>
            <begin position="369"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022103552.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="56051" checksum="DB40A77B444BA22C" modified="2022-01-19" version="1">MENSTENRMEINEDVAEAKKNEGNTSYKNGDYEAAIRLYTEAIDICPDCASYYNNRAAAFIMQDKYQQGLEDVQRALTLDNTLVKGYLREAKCHLALGSADAAIRSLNHVADFEPQNKQAQSELRAAKLVQHHDQDGHKAFEAGDFRKVVYNMDRAIDHSPACTKFKVKRAEALAKMRRITEASQAINAVLMREPRNADAIYVRGLCLYYQDNMDKAIQHFQQTLKLAPDHSPARIAFKKCKLLKSKKEEGNEMFKRGNYQEAYGLYTEALQVDPLNVNTNAKLYCNRATVCSKLNKPDQGILDCNKALELDPDYLKAFMRRAKCYMETEQYEEAVRDYEKVCQMDRSRENKALLQEANLELKKSKRKDYYKILNISKNATEVEIKKAYKKHALLHHPDRHSNKTEEVQKAEEVKFKEVGEAYNVLSDSKKKMRYDSGQDLDDLEGFGGFDPSQIFTSFFGHPGGFSFGHGGGGGGHRDSGFYGGGFPGGFQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFZ3</accession>
    <name>A0A8B7ZFZ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Coiled-coil domain-containing protein 127-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110986710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104524.1">
        <property type="nucleotide sequence ID" value="XM_022248832.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104525.1">
        <property type="nucleotide sequence ID" value="XM_022248833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFZ3"/>
    <dbReference type="GeneID" id="110986710"/>
    <dbReference type="KEGG" id="aplc:110986710"/>
    <dbReference type="OMA" id="HIQINRD"/>
    <dbReference type="OrthoDB" id="10064762at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034607">
        <property type="entry name" value="CCDC127"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31958">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31958:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022104524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022104525.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="25810" checksum="C17018A69F1812E3" modified="2022-01-19" version="1">MATNDLNIPPTEEPIGKKLSRIASQLLIPVLLPASSIFFGWLAQRRISIQLNQLQKEKERIADLKEDVDFLQDEVKNLSKRRLELEEKTSMTTIKRRCLLEEAIIKEENQATQKILTELEELRPLLKQRQDIYCNPFKYRGPRLELESQLLFSAYFKPYDKDLGLYVGMQNILKHDQSCSQEGNGCLMWVYLQLWKTRAELLKHRRVAARMKEVDESFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGA9</accession>
    <name>A0A8B7ZGA9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lactose-binding lectin l-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102276.1">
        <property type="nucleotide sequence ID" value="XM_022246584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGA9"/>
    <dbReference type="GeneID" id="110985512"/>
    <dbReference type="KEGG" id="aplc:110985512"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034657653" evidence="2">
        <location>
            <begin position="20"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="39"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102276.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26187" checksum="CCFCC99F949E01DD" modified="2022-01-19" version="1">MALACLLFLLCVGCCYTTCQEVRCMGSIGGTCPPTWSQWEGKCYNATGRGLGWPEAAQECIQMGGVMAVPRSQNESKFFASLMPANNREFWINCKCSQQGDPWVCQEGATRVPLDESVQWDSDTNGDNEDCIKVKQCDWKWKWELCTQPLPAVCKKPVDPMLHFYDSWVCSGVMTDPKSTFDWGDIRLNNRGADGEDCMGLHVENSRLMLEDSQCDYRFKAICKKATPELHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGZ7</accession>
    <name>A0A8B7ZGZ7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phenylalanine 4-monooxygenase</fullName>
            <ecNumber evidence="3">1.14.16.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110986913</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022104913.1">
        <property type="nucleotide sequence ID" value="XM_022249221.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104923.1">
        <property type="nucleotide sequence ID" value="XM_022249231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGZ7"/>
    <dbReference type="GeneID" id="110986913"/>
    <dbReference type="KEGG" id="aplc:110986913"/>
    <dbReference type="OMA" id="HEVFGHC"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004505">
        <property type="term" value="F:phenylalanine 4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.800.10">
        <property type="entry name" value="Aromatic amino acid hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001273">
        <property type="entry name" value="ArAA_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036951">
        <property type="entry name" value="ArAA_hydroxylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036329">
        <property type="entry name" value="Aro-AA_hydroxylase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019774">
        <property type="entry name" value="Aromatic-AA_hydroxylase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473">
        <property type="entry name" value="AROMATIC AMINO ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11473:SF24">
        <property type="entry name" value="PHENYLALANINE-4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00351">
        <property type="entry name" value="Biopterin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00372">
        <property type="entry name" value="FYWHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56534">
        <property type="entry name" value="Aromatic aminoacid monoxygenases, catalytic and oligomerization domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51410">
        <property type="entry name" value="BH4_AAA_HYDROXYL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biopterin-dependent aromatic amino acid hydroxylase family profile" evidence="9">
        <location>
            <begin position="9"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022104913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022104923.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37265" checksum="DB61F67A70482B8D" modified="2022-01-19" version="1">MSEFPDDSCCVTHPVADGSDEVEFPRNFAELDYSLTREVYDVIQPNVKGFDDAKYRSFRRKCQLVTKTYKLGTPIPSMIYPASQLETWARTYNRLMLLYPMHACTKFNNLLAPFLEACDISAHRIPDLEKVSNYLRRKTGFRLRPVSTFMTPRDFLAALAFRVFCSSQYVRHGDGAFFTNEPDVIHEILGHAVLLCDAEFAQFSQDIGLASLGTPDHILDKIASVYMSTVEAGLCREGSEVKAYGALLLSGSNELEHVFTDKAVKRPLEIEAAASLPDIDLDKYQDVYYVSESIEEAEQMARAYVSSLPCRMSVKYNPEKNVIEPKDKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHJ0</accession>
    <name>A0A8B7ZHJ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NF-kappa-B inhibitor-interacting Ras-like protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102726.1">
        <property type="nucleotide sequence ID" value="XM_022247034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHJ0"/>
    <dbReference type="GeneID" id="110985755"/>
    <dbReference type="KEGG" id="aplc:110985755"/>
    <dbReference type="OMA" id="IMDRANN"/>
    <dbReference type="OrthoDB" id="10002389at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032484">
        <property type="term" value="P:Ral protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042227">
        <property type="entry name" value="KBRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46152:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-INTERACTING RAS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102726.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22439" checksum="8EDD227430E42F1C" modified="2022-01-19" version="1">MGRTCKVVVCGSSCVGKTALLEQAIFGNHVIGNQNSIATIEDIYVASVESNRGVRERVRFYDTRGLDPKTNPELPKHYFAIADGFILVYSITSSESFQQVQLLKKEVDKISKEKDKREVSLIVVGNKADLYKERQVEYDMVCAWAQKEKVPLYEVTVANRKVLMEPIVALTSKLTLPIVKSSFPLRIKPKQMTSTASHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIG2</accession>
    <name>A0A8B7ZIG2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Battenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC110987171</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Lysosome membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105347.1">
        <property type="nucleotide sequence ID" value="XM_022249655.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105348.1">
        <property type="nucleotide sequence ID" value="XM_022249656.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105349.1">
        <property type="nucleotide sequence ID" value="XM_022249657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987171"/>
    <dbReference type="KEGG" id="aplc:110987171"/>
    <dbReference type="OMA" id="WLCNWQV"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022105347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022105348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022105349.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46198" checksum="0543CE17ADC0F8E7" modified="2022-01-19" version="1">MTETPRLETXVAFWLLGLCNNYAYVIMLSAAYDILEKKDTVPDSDVEPMDTMYNLTNSTSAGRFDCNPISTGAVLLADILPTLIIKLSAPWFADYIPYSARIALCVLAAASSFIIVSLVHLVALSLMGVVFASVSAGLGEFTFVSLMSFYDKNVVSTWSSGTGAAGLIGALSYAGLTEVLTPRNALLVMLVVPVAMAISYWGILVRVPTSKPLQDDQPVDEARRRLLECDSMEDANKDTQTPSQEHLTLKERLFHIKHLLKYMIPLMLVYFAEYFINQGLLELIFFQGIWLDHQGQYRWFQVLYQLGVFISRSSVNFVKFKRLWIFSILQWCVLVLMFTVAYYAYMPSIAIVFAIILFEGLLGGAAYVNTFYQIRQNESPKYKEFAMGTTTVAESCGTSLAGAAALPVHNALCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZK38</accession>
    <name>A0A8B7ZK38_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LOW QUALITY PROTEIN: fermitin family homolog 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110986246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the kindlin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103671.1">
        <property type="nucleotide sequence ID" value="XM_022247979.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986246"/>
    <dbReference type="KEGG" id="aplc:110986246"/>
    <dbReference type="OMA" id="PEHGIHY"/>
    <dbReference type="OrthoDB" id="10057618at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030055">
        <property type="term" value="C:cell-substrate junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13205">
        <property type="entry name" value="FERM_C_fermitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17095">
        <property type="entry name" value="FERM_F0_kindlins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17096">
        <property type="entry name" value="FERM_F1_kindlins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01237">
        <property type="entry name" value="PH_fermitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037843">
        <property type="entry name" value="Kindlin/fermitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040790">
        <property type="entry name" value="Kindlin_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037837">
        <property type="entry name" value="PH_Kindlin/fermitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16160:SF13">
        <property type="entry name" value="FERMITIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18124">
        <property type="entry name" value="Kindlin_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="5">
        <location>
            <begin position="208"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="400"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103671.1"/>
        </source>
    </evidence>
    <sequence length="699" mass="79636" checksum="7A071824A5DDA519" modified="2022-01-19" version="1">MDPHMYKLPDGKYADGSWELNIYVTNLELEKQIRVTGDLHIGGVMLQLVESLDLKEQRDWSDHAIWWPEKNQWLKRTGSTLDQCHVQADARLQFTPMHKTLRVQMPDMQLVDIRVDFSTDVFSSVIELSKEVGVRHPEELSFLKKPNARASTVKQRSNGRKKKDRDRDSMASSNSNEAASTGSLDGIPPHTPTRRPSPGFNRQMTPGSVNSTPGHNGNTTVLSVHSSGSNFSDSFENLNMSLLNSPRTPSREAREGLIRPNNYREKAAINAGWLDSSKSLMEQGIQENDTLMLRFKYFAFYDLDPKQDGVRINQIYEQAKWGLLNEEIDCTDEEMIMFAALQLQVNLQAQMPQPDRKLXQEGQDDIDKALTNLQVSLEGSSITTGQSDITTVPELCDNLRFFRPKKLTLKGYKRGYFIFRDTHLTQYKAQEDNHGPPVQTLNLSGCEVSHEVSIPHDKYGIKLLAKAPEGPIELWLRCESEEQYAKWLAACRLASKGKTMADSSYQSEVQGIQAFLSMQHSKKTSSPSITTENVDIQAEDYVSPRFLKKHKPKQVAARILEAHTSVRNMKLMDAKLNYIKAWQALPEYGVTYFVVKFRNCKKEELIGVAYNRLIKMDINSGDSQKTWRYSTMTAWHVNWEVKEVLVQMEDENIQFSCASADCKVVHEFIGGYIFLSMRSLDSNQTLNEEMFHKLTGGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKC9</accession>
    <name>A0A8B7ZKC9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette sub-family C member 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987169</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105345.1">
        <property type="nucleotide sequence ID" value="XM_022249653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKC9"/>
    <dbReference type="GeneID" id="110987169"/>
    <dbReference type="KEGG" id="aplc:110987169"/>
    <dbReference type="OMA" id="TNACRTP"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18602">
        <property type="entry name" value="ABC_6TM_SUR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000006">
        <property type="entry name" value="ATP-binding cassette, sub-family C (CFTR/MRP), member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002366">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF461">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C MEMBER SUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="685"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="874"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="339"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="645"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="963"/>
            <end position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105345.1"/>
        </source>
    </evidence>
    <sequence length="1200" mass="132940" checksum="44570D7A46B65AAD" modified="2022-01-19" version="1">MGITIIAATFQFIGAHKCFFYSTFYGMCLRSSIQTMVYEKSLSLSTFASTGGEMTAGQITNHMSTDAMNLLYMFQYLHFTWTVPFLVALVMYLLYEALGVAALLGAVVYLVVIPLQLVIANFMAKHQKRALNLADERLRYSNEILQGIKLLKSYGWEHLYLRVVENIRNRELMSLLKMNAAYGLIGFIVSSSPLVVTLLTFGTYTVFSGESLTPEKAFSSLALFNQLSGPLFMLPLVTAALVNGVISTTRLQRFFMAQEVEKSCTGRDWRDTVEGQGPHDDNEQETTLERIKDDITSDVDETTHMLPKIEVSKTKRFDGYRAMNSTKATRNRLPESVAIEITNGNFTWDKSSSIPIISNINVDIPAGKLTMVIGSVGSGKSSLVSAIQGEMTTLSGTVQLNEGTSSIAYAAQKAWLINSTLQGNVLFGKELDTKKYKKTIDVCALKPDIEILPGGDQTEIGEKGINMSGGQKQRISIARTVYSDKDIVILDDPLSALDVHVGSQVFHKAIVGTLLKKKRTVLLVTHQLQYLHHAHKIIVMKDGKVAHQGTLQDIIDEAPELYSEYQRAVKTATESETETEDIMSRMSDEEKREVFKRKINRELSVESSSSKTGTKLIKEEEMERGSVSYKVYAFYCRAMTWTMSIGFLAGYVGNAGFTVGTNFWLSEWSTAGITTDNSTIKPLSYYIAGYAGLSVGGVVTAFVGCMFIVFGAYVASRDLHISMLRNITKCSMRFFDTTPLGRVLNRLAADTTILDMKLFQSMDATVFFSVNYVSGLVVNSIILPIFLIFAAPMVVSYYFLAKFYVTTSRSLQRLDSVTKSPVFAHFSETLGGLPTIRAYRDQDRFYSTLMKKVNVNNTAFLYLQTSNRWAGMRLESIGVIGILIAGVGTIISSLNGTIEPSEVGLAVSYTLVVANFMNFAVRFAAETEMQMNAIERVKEYSSIANEDYTGTEPPESWPQRGEIKMNGIYVRYAKELDPVIKNATVTFKSGEKVGICGRTGSGKSSLTLALFRIIDTCKGSILIDDIDISTVPLTTLRQRLAIIPQDPVLFSGTIRYNLDPEKQRTDGELWHSLEISQLKDTVSQMPKGLDSDVSEGGENFSVGQRQLFCLARAFLRRSKILIMDEATASIDMDTDKILQEVVATVFADCTVLTIAHRVATILDSDSILTLADGEIVEYDTPEKLLANHNSIFASLVNSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMF4</accession>
    <name>A0A8B7ZMF4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110987563</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022106075.1">
        <property type="nucleotide sequence ID" value="XM_022250383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMF4"/>
    <dbReference type="GeneID" id="110987563"/>
    <dbReference type="KEGG" id="aplc:110987563"/>
    <dbReference type="OMA" id="YLVMESR"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022106075.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="37407" checksum="9054D788EC8869D0" modified="2022-01-19" version="1">MADTDKINVDNIIHRLLEVRGARPGKNVQLTEAEIRSLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCCHGGLSPDLQAMEQIRRIMRPTDVPDQGLLCDLLWSDPDKETSGWGENDRGVSFTFGPEIVSKFLSRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKKKFPYGGINSGRPVTPPRGQGKNKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP59</accession>
    <name>A0A8B7ZP59_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Development-specific protein LVN1.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107373.1">
        <property type="nucleotide sequence ID" value="XM_022251681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP59"/>
    <dbReference type="GeneID" id="110988310"/>
    <dbReference type="KEGG" id="aplc:110988310"/>
    <dbReference type="OrthoDB" id="10070532at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034572658" evidence="1">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107373.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28359" checksum="DE63000723053696" modified="2022-01-19" version="1">MNRCSVVRLVALLAATVLVADADNYCCTAPQFVIRADQLQGLQLPSGQGIAQLNVLDMALDFTNERAGEEIDSYSMGRLTKIKVIIDKKKNVMYTIIGQNCTKTEARGEFLQCIPKTAHFDGSSYLGDNELTLDAFSFPLDEPKVVRGNVTVSVTHGNCIYAGTWLVGEATQTEPPIPLVSSTSFVNFKRGIADPSRWFDVPSFCQQEKSTRARRSVRPVSDDHKDVMKLVSIFNTMMLPDVGHAKVLKPQKPSSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQJ6</accession>
    <name>A0A8B7ZQJ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 367-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110988467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107674.1">
        <property type="nucleotide sequence ID" value="XM_022251982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQJ6"/>
    <dbReference type="GeneID" id="110988467"/>
    <dbReference type="KEGG" id="aplc:110988467"/>
    <dbReference type="CTD" id="195828"/>
    <dbReference type="OMA" id="NKHPHVI"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000474">
        <property type="entry name" value="zinc finger protein 367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF26">
        <property type="entry name" value="ZINC FINGER PROTEIN 367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="225"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022107674.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32487" checksum="C61836B6C491487B" modified="2022-01-19" version="1">MASVLTNSPQKICPNAIIRSPVRPLQLPRSPVSPGLAEFYPWKWSESARNVQLSPGSSCGSPGSERGFTPRQSSGPIPSPRGRPRAEVIPELQKEGSTSGHGIRCKICQRVFPREKSLQAHIRTHTGERPFKCDYPNCSRAFVQSGQLKTHQRLHTGEKPFYCPAKGCRSRFTHANRHCPDHPYLTLQRESTETLLEEILSNDENSEDVNRWLQRYVENYRERLETKTQEQAKRKREQELLAENGSTPKRPRASARRRLQEQREKMLGAMALMELAQKLPADSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRT3</accession>
    <name>A0A8B7ZRT3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15 16" type="primary">LOC110988507</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
            <location evidence="1 10">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107777.1">
        <property type="nucleotide sequence ID" value="XM_022252085.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107786.1">
        <property type="nucleotide sequence ID" value="XM_022252094.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107794.1">
        <property type="nucleotide sequence ID" value="XM_022252102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRT3"/>
    <dbReference type="GeneID" id="110988507"/>
    <dbReference type="KEGG" id="aplc:110988507"/>
    <dbReference type="OrthoDB" id="413723at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000003">
        <property type="entry name" value="kinesin light chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002151">
        <property type="entry name" value="Kinesin_light"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015792">
        <property type="entry name" value="Kinesin_light_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF3">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01160">
        <property type="entry name" value="KINESIN_LIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="150"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="507"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="626"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="626"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022107777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022107786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022107794.1"/>
        </source>
    </evidence>
    <sequence length="678" mass="75648" checksum="DF76DA2456A58FFF" modified="2022-01-19" version="1">MSSSSSGGTQVLNQEAISSGTKEVIKGLEQLKNEHNDILNSLYQSLKVVKKDHGDSNLVEEKTGIIEKSLESLELGLGEAKVMMALGHHLNMVEAEKQKLRAQVRRLVQENAWLRDELAATQQKLQTSEQNLAELEEKYKHLEYMNSIKKYDEDRTPDTEETAEPLDLGFPEDEDDQQQPEDQYPQQQASPGAAAAAAGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAGNLLHDALAIREKTLGPDHPAVAATLNNLAVLYGKRAKYKEAEPLCKRALEIREKVLGTGHPDVAKQLNNLALLCQNQGKYEEVEWYYKRALEIYETKLGPDDPNVAKTKNNLASAYLKQGKYKAAETLYKQVLTRAHEREFGGTDDKDIKPIWMQAEERQEKGKFKDNAPYGEYGGWHKAAKVDSSSPTVTTTLKNLGALYRRQGKYEAAEILEECAMRSRKNQAADAVKESRVRELLNKDLSTDVPRHEANRKHDHRRGGSGPGSRRESTDSVSYEKHDGTEEVSIGAVWSGSENGLKRSGSLSKLRASVRRSSTRLLNKLKGRESDDEGGSDIFDDFVDMVKSGMKRASSMSVLTSRANDDASSPIQLSQRGRVGSHDNLSSRRQTDDLLSVDIKGVQEQVEEPPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU43</accession>
    <name>A0A8B7ZU43_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell adhesion molecule 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110989203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109083.1">
        <property type="nucleotide sequence ID" value="XM_022253391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZU43"/>
    <dbReference type="GeneID" id="110989203"/>
    <dbReference type="KEGG" id="aplc:110989203"/>
    <dbReference type="OMA" id="CSNSQHT"/>
    <dbReference type="OrthoDB" id="10048737at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051275">
        <property type="entry name" value="Cell_adhesion_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640:SF31">
        <property type="entry name" value="IRREGULAR CHIASM C-ROUGHEST PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11640">
        <property type="entry name" value="NEPHRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="92"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022109083.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="21920" checksum="D938672BDB8E6BE9" modified="2022-01-19" version="1">MLCSNSQHTSGFAQWSDITDPSNPVPFASRSGGVLKDPPTYSKYVNFDLDTTLSTQLDLKISSAELEDEGTYSCTLNPDTVSATLTVERAEPTITIDGDSSGNPIILRALEPSVLRCTARGFRPAVNLEWYKNSAQISTGVSPEAPTPNGDAFDTSGTLTFTPTRQDNEAILECRTTGQVVAPAKTASLTLNMYQSCQLGMPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUM1</accession>
    <name>A0A8B7ZUM1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-3 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110989289</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109263.1">
        <property type="nucleotide sequence ID" value="XM_022253571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUM1"/>
    <dbReference type="GeneID" id="110989289"/>
    <dbReference type="KEGG" id="aplc:110989289"/>
    <dbReference type="OMA" id="DFWHYPL"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF411">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01102">
        <property type="entry name" value="5HT6RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="29"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022109263.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36382" checksum="61BA3DE4F69D4000" modified="2022-01-19" version="1">MPDEGPSPPWFNVFRCILLSLTTVLIIGGNSFCLLILRRVHGIHEVTRLFMASLALSDLLTGVFVALPMVVSTAMDRWPYGDTFCGIYGVGKYVCYYTGLISLIAVTVERYIMVVCPLRYHTIVTLFRARVAVAVIWLLALAITMFFGGSVNFVGDVDEDEDNCSLDTEKGDFWHYPLKYMAVVFILVPVVTVLVLYTHILLIARRQICRIAAVAPLGPMSEEERAAVRTRQANRRAAGTFLIVTMAFAVAWMPSAVRKLNKLATGISDTMYTEFLARFCMLSNSWLNIFVYYIRNESFRQTARRYIAAIRGTRTSDAIEISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV16</accession>
    <name>A0A8B7ZV16_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110989374</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109403.1">
        <property type="nucleotide sequence ID" value="XM_022253711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV16"/>
    <dbReference type="GeneID" id="110989374"/>
    <dbReference type="KEGG" id="aplc:110989374"/>
    <dbReference type="OMA" id="VAGQCEL"/>
    <dbReference type="OrthoDB" id="10146923at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022109403.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32303" checksum="8884281EA54BD204" modified="2022-01-19" version="1">MGAMVTMMAVVAGETVITRIPNDRYDDNAGHHDKSDNEGHNEKEVIMPKSPPYDDDIGYDSCDDISKLMSRQRKQQWQWRKRDDSFESRSASQNHCCPSCTLQAITPLNVDQIQQIRSNQALIQQIKSKPMLVYDPAYQRSVVDLTLQQQFQIRRNIPHLFMSVDDFKKSNVTRGRITVPGEEMRNRRKRQAIGTRVCQPVPRVNPLILATTVDGEVVEIIQMPGQGMNQWILEETCDNAASTPPSTLTCGLAERHVPAAFISVSTEPYIFDLAYVVVQSCVSLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWM4</accession>
    <name>A0A8B7ZWM4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Kelch-like protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110989237</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109165.1">
        <property type="nucleotide sequence ID" value="XM_022253473.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109166.1">
        <property type="nucleotide sequence ID" value="XM_022253474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWM4"/>
    <dbReference type="GeneID" id="110989237"/>
    <dbReference type="KEGG" id="aplc:110989237"/>
    <dbReference type="OMA" id="KYLGPPY"/>
    <dbReference type="OrthoDB" id="6418787at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF5">
        <property type="entry name" value="KELCH-LIKE PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="89"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022109165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022109166.1"/>
        </source>
    </evidence>
    <sequence length="655" mass="72639" checksum="8E35F2B36703C07F" modified="2022-01-19" version="1">MSSLSDRSPQAPEGPDPDLDIDTSPVQLHLDGPDPTDPEPSKGPPLSPPLPAGKNSWGEGQGYFESPIPGHSEALLVELHRQRLNGRCLDFRLDCNGVTLPCHRCVLAASSSYFDKALSELEQGQDRLNLDNLKPCALEAVVDFIYTGRFKVSEAMAAGVLCTACILEYPVLIEQCCRFLNGIICFENCVGIFQLSQEYGCAKLQQTAWQFALENARDVFKETEFLKLSVDHLVEYISHDGLNIELEDAVFEAVLRWVEHDETNRVTSLPSILQHIRLPLLSNRLFSSSLESHPLIVNCSKCRQLVKEARHLRDLALKGKDIHSKSLKPRPSMMKDVLVVVGGMETSRTWVKEVIYYDPATQAWETLSTLPFSQTDYSVASLNDDIYVSGGFKMGNATSEVWGYRTAQDKWVEVASLKLARFNHASTALDGMLYVVGGETDDAGLMEIERYDPQRDVWEIIGEANPTQSNLTVAGLNHKLYIVGWLAHTRLMCVVQCFDLQTRECTIQPCSGLNRQLFPVITFQDSIYILGGSRIKEVAIYDPETYQSIKGEPMKYKRNTPSAAVVGPFLYVTGGELQHHLAKVEVFDPDSNSWSVVPPMPTALCFHGCVGVRKYLGPPYIEPTGQIAGTSAGECYGASPEVSPDIIKVTNDCHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWS7</accession>
    <name>A0A8B7ZWS7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Zinc finger Ran-binding domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17 18" type="primary">LOC110989639</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the ZRANB2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109873.1">
        <property type="nucleotide sequence ID" value="XM_022254181.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109874.1">
        <property type="nucleotide sequence ID" value="XM_022254182.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109875.1">
        <property type="nucleotide sequence ID" value="XM_022254183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWS7"/>
    <dbReference type="GeneID" id="110989639"/>
    <dbReference type="KEGG" id="aplc:110989639"/>
    <dbReference type="CTD" id="9406"/>
    <dbReference type="OMA" id="WICPDID"/>
    <dbReference type="OrthoDB" id="1878647at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000004">
        <property type="entry name" value="Zinc finger Ran-binding domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017337">
        <property type="entry name" value="ZRANB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12999:SF17">
        <property type="entry name" value="ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12999">
        <property type="entry name" value="ZINC FINGER RAN-BINDING DOMAIN-CONTAINING PROTEIN 2 ZRANB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037956">
        <property type="entry name" value="UCP037956_ZnF_Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="14">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022109873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022109874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022109875.1"/>
        </source>
    </evidence>
    <sequence length="339" mass="37846" checksum="4E62CE1D6D001F96" modified="2022-01-19" version="1">MSRRHSSNEGDWVCSDPKCGNVNFSRRQQCNRCGADKSHITIKAGGSAIGKQLAEKSKGLFSADDWQCKTCGNVNWARRTDCNLCKTPKFGKVEARTGYGGGYNEREGVEYKSGQEDSDGEFDDFGRKKKKFRGTVPPKPAAAEGKEKVEDEEESGDDADLDAYKLDSDDDDDDDDDDGDLSKYDLDGDDDDSAKDAKKLLDASWDRGRSASRSSRASSSSSRSSRSSRSRSSSRSSYSRSRSRSRSGSHDRKYGIQGGSPDPHRGHGDSSSSSSERREGGRRRSPNPHRRRRDSSSSSSERREGGRRRNPNPHRRRRDSSSSERQEGYKRQRHCSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A090</accession>
    <name>A0A8B8A090_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MIP18 family protein FAM96A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110990406</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111094.1">
        <property type="nucleotide sequence ID" value="XM_022255402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A090"/>
    <dbReference type="GeneID" id="110990406"/>
    <dbReference type="KEGG" id="aplc:110990406"/>
    <dbReference type="CTD" id="84191"/>
    <dbReference type="OMA" id="HELGYRN"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000004">
        <property type="entry name" value="cytosolic iron-sulfur assembly component 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF2">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034852554" evidence="4">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022111094.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20354" checksum="1FACB7FABA492D70" modified="2022-01-19" version="1">MILTFLGLFQLFMMSATSHGSSTVADGGQTSKSTEAEPGTSCGWDEEEEENLEDIAADIYDLIKDIRDPEKPNTLEELEVVFEQGVKVHPLQEGSDRYIIRVEFTPTVPHCSLATLIGLCIRVKLDRSLPQKHKIDIFITKGTHSTEDEINKQINDKERIAAAMENPNLKELVERCVADHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0G7</accession>
    <name>A0A8B8A0G7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ly6/PLAUR domain-containing protein 6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110989331</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109331.1">
        <property type="nucleotide sequence ID" value="XM_022253639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0G7"/>
    <dbReference type="GeneID" id="110989331"/>
    <dbReference type="KEGG" id="aplc:110989331"/>
    <dbReference type="OrthoDB" id="6149028at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030548">
        <property type="term" value="F:acetylcholine receptor regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23567">
        <property type="entry name" value="TFP_LU_ECD_LYPD6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039457">
        <property type="entry name" value="LYPD6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31171">
        <property type="entry name" value="LY6/PLAUR DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31171:SF3">
        <property type="entry name" value="LY6_PLAUR DOMAIN-CONTAINING PROTEIN 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16975">
        <property type="entry name" value="UPAR_LY6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022109331.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23058" checksum="B71C1B38DC858020" modified="2022-01-19" version="1">MSMGMYVKRSTRFLNDVFLQNAVKKHFVMLVCWPKVIQQWLSAAIFCLVFMSSCCAPTEPTLIFSYDDSTPFPNAVKCFTCIDKKSNRECNERAYDAFCPKGTKYCYSSHYVNQKTGESILVNKKCALTEDCTTNTVGCTDTSTKHVQRCVSCCEGTQCNVLSPHNSTTAVFSTLTPLNTAPLLRIPNVILILGLMTVTRILRLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A147</accession>
    <name>A0A8B8A147_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LOW QUALITY PROTEIN: uncharacterized protein LOC110990631</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990631</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111404.1">
        <property type="nucleotide sequence ID" value="XM_022255712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A147"/>
    <dbReference type="GeneID" id="110990631"/>
    <dbReference type="KEGG" id="aplc:110990631"/>
    <dbReference type="OMA" id="PDAPCHS"/>
    <dbReference type="OrthoDB" id="6131287at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111404.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34875" checksum="7A13B8CF6C548C1C" modified="2022-01-19" version="1">MNLYLSVLPLFKSFILIFEQKQPMCHRLHDEMVDLFKHFFSLKHSVRDEQKKTVREFRTLVGEAYISSAVYMQAKFPVHNLLLRYLSAIDPAVQGHSQTFPALKKIGELFTTGITDTEKDAYRHEVSAVQTNTSLPPTKVGEQSVHLHVYHWGTKVFKTQKYPTLSNVIKACLSIFTGPEYVERSFSTVNDLISSKANRLEVDTFSPMQYIKYELSSKHTTSLQLYHRKDVIKSPIDRSLIYHMQTANGRYKRRLEATRTEKEATSKRMKVDIVKHGNPSGRKTAIHKTAQDIKRRGTLGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A193</accession>
    <name>A0A8B8A193_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pumilio homolog 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110989498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109616.1">
        <property type="nucleotide sequence ID" value="XM_022253924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A193"/>
    <dbReference type="GeneID" id="110989498"/>
    <dbReference type="KEGG" id="aplc:110989498"/>
    <dbReference type="OMA" id="RGMMHAN"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035196">
        <property type="term" value="P:miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="7">
        <location>
            <begin position="845"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="865"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="901"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="937"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="973"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1009"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1045"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1081"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="1122"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="710"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="742"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022109616.1"/>
        </source>
    </evidence>
    <sequence length="1207" mass="131622" checksum="568D0035C23F1418" modified="2022-01-19" version="1">MLSEINGILSDLFWVATVHGMRDPHPETNGVDPMSSSTEMSDNAWDDSRIAQQTSGSHRPQQQGAPVAPQRARDDAAVGYFYQRPGSDMVADGGGQAGNKQRWAVGDDSVIDQVRSGDVSKVNNMFQSLQIGNDGREFDVSTKKFWDNDESKGDMFLNQWPVPGSQTWGVPTSDHAVSQPIMVQRRLSPATFQGQENTVLSPRSDSGGLGLSMAEYVLATSPQGKADMEGKLNHRLKTGFPGPGPAGDADTANKNGTKKSKTPSPFEEGEEKKAENNGIPHKEDDGPYMRNPGSRNASPTENEDPRLQHAHQNPSMAPDPSHHQQPPQQQQQQQHRTMYQQRSQQAAAHHGLTQQEVAYIEQQQQQQQQQVPGQLQIDTGQMDSGSNMSDQLQFDYSAQQMVPSMDSPSYVDYSQGQPGSVQMFQQRQATPQAITVQQLTPQQQQYAIAAAAQQQQLGLAQTAFAPNPYIITGGPNGQDPYSVAIPGGATVVQPQYAYGVAPWSVYPVGIIQQQQGQQQQGQQQQPQQQQQQVRGQNGRPMTPQQQQQQQQQQQQQQQQQPPQGDQAGNQATSNQAAAMAQAQAQALQAGYQVLAPAYYDQTGALIINPRPGTVGAPMRLVPPAQVIVSAPQQASVMNGLPANGFRLMGNQQQGQQQGPAALSMYGSNAMASNAPQNSAGSLGTYTPTSSVFSNGSIGAVGSSVGAIGTSLGSSGPDSPTARRDSLTGSDYKRQGLSMSQFYGSSPQLGPIGMPSAGGSLTPPPSQSGLGGLGLDNLLTAPSSSWDRTLQKRDWGAGRAVNPAAPFGSEVKFRSGAATTSSGWSNTLFPPRSLRSSAYMEKSAPGRSRLLEDFRNNRFPNLQLRDLSGHIVEFSQDQHGSRFIQQKLERATSSERQMVFSEILGAAYSLMTDVFGNYVIQKFFEFGTTEQKQALAQRIRGHVLPLALQMYGCRVIQKALESIPPELQLEVVQELDGHVLKCVKDQNGNHVVQKCIECVDPVGLQFIVEAFRSQVYSLSTHPYGCRVIQRILEHCTVDQTKPLLDELHEHTESLVQDQYGNYVIQHVLEHGRPEDKSKIVAELRGKVLALSQHKFASNVVEKCVTHSSRPERALLIDEVCSFNVNDGSNSALYTMMKDQYANYVVQKMIDVAEPNQRKILMHKIRPHVGTLRKFTYGKHILAKLEKFFMKSSNDLGPIGGPPNGSLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1G7</accession>
    <name>A0A8B8A1G7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Acyl-coenzyme A thioesterase THEM4</fullName>
            <ecNumber evidence="19">3.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Thioesterase superfamily member 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29 30" type="primary">LOC110990477</name>
    </gene>
    <organism evidence="28 30">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40151"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40152"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:40140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the THEM4/THEM5 thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="19"/>
    <dbReference type="RefSeq" id="XP_022111201.1">
        <property type="nucleotide sequence ID" value="XM_022255509.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111202.1">
        <property type="nucleotide sequence ID" value="XM_022255510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1G7"/>
    <dbReference type="GeneID" id="110990477"/>
    <dbReference type="KEGG" id="aplc:110990477"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052365">
        <property type="entry name" value="THEM4/THEM5_acyl-CoA_thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12418:SF19">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE THEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thioesterase" evidence="27">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022111201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_022111202.1"/>
        </source>
    </evidence>
    <sequence length="172" mass="19190" checksum="6C65DF6BE3F15140" modified="2022-01-19" version="1">MASSPKSHWEWLEETEALFTRLEAEPGWTQMRSSKTDHQTKHVFSRAVTENGPIIHFGVFLHENDGKLRGLCQFGEDANSYMKGLVHGGAIATMHDTTTGVLAMNMGAKLMYTRYLNTTFLRTTVLMEAVIDKVDGNKTFLKGYLKSPDEKTVYSECTALYVNADKAAGSNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3G3</accession>
    <name>A0A8B8A3G3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990689</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111475.1">
        <property type="nucleotide sequence ID" value="XM_022255783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3G3"/>
    <dbReference type="GeneID" id="110990689"/>
    <dbReference type="KEGG" id="aplc:110990689"/>
    <dbReference type="OrthoDB" id="547680at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051941">
        <property type="entry name" value="BG_Antigen-Binding_Lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713:SF6">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45713">
        <property type="entry name" value="FTP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111475.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="20647" checksum="4FE918FDB7F5671F" modified="2022-01-19" version="1">MDGMKGEEARKMDGIMGGCSGGDGLGGWIEGLGDGLAHRLGGNVVRAGLNSNHLLNPEIGRVAASQTLSRAVIDFTPEPYVIAQYVSVDIHGSDPQTMVQLTEVMVEEVNTATMKQATGKGLFLTGRPSSQSSTFTDSGDMRLASRAVDGHLQYVNPHCSQTNVQESPWWMINLTAVHCIRKVAIRNIDDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3J7</accession>
    <name>A0A8B8A3J7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carboxypeptidase D-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110991093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111952.1">
        <property type="nucleotide sequence ID" value="XM_022256260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3J7"/>
    <dbReference type="GeneID" id="110991093"/>
    <dbReference type="KEGG" id="aplc:110991093"/>
    <dbReference type="OMA" id="GHEPYLT"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03858">
        <property type="entry name" value="M14_CP_N-E_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000020">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057247">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF84">
        <property type="entry name" value="CARBOXYPEPTIDASE M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00133">
        <property type="entry name" value="CARBOXYPEPT_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M14" evidence="10">
        <location>
            <begin position="48"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022111952.1"/>
        </source>
    </evidence>
    <sequence length="478" mass="53476" checksum="1FE162EA569D5E97" modified="2022-01-19" version="1">MRKKSRWSSLTPLRINECNSVMTSGRAVHFLLFVISCGVCALPIVKFEYHNHAQLTSVMTSLTNMYPDTSHIYSIGKSVQGRDLWAVAVAGKKPHGRIIGRPEAKYVGNMHGNEAVGREVLLHLIEYLLKEYRGGNPQIRKLMDTTRIHIMPSMNPDGFEVSKQRCRGVDLRANSNGYDLNRNFPDYFEPTVDPIQPETKAVVDWIHGNKFVLSANFHGGALVANYPYDTGQPGTERPMDTAYHQSPDDDVFRFLAKTYSKAHPRMHLVQENICSPNTDTGFVDGITNGADWYSVAGGMQDFNYIFGGCMEITVEMSCCKYPAASELRAYWEENRSPMLEFLKQANRGVKGQVFNTDNRPIEGASVSIVELKSPHPQFTTSLGEYWKILLPGSYTLLVSKYGYATSNQKFTIHHDSPDPVVLNISLFSANVNQHVENVTDWTPSTAVVCKQARETVVVVTMFSLFIQVGLVGSVSRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A7Q4</accession>
    <name>A0A8B8A7Q4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">von Willebrand factor D and EGF domain-containing protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110991163</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112071.1">
        <property type="nucleotide sequence ID" value="XM_022256379.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110991163"/>
    <dbReference type="KEGG" id="aplc:110991163"/>
    <dbReference type="OMA" id="DGMAHND"/>
    <dbReference type="OrthoDB" id="382013at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057774">
        <property type="entry name" value="D8C_UMOD/GP2/OIT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050969">
        <property type="entry name" value="Dev_Signal_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058727">
        <property type="entry name" value="Helical_Vwde"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057885">
        <property type="entry name" value="Ig_VWDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949">
        <property type="entry name" value="EGF-LIKE-DOMAIN, MULTIPLE 7, 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14949:SF51">
        <property type="entry name" value="VON WILLEBRAND FACTOR D AND EGF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17963">
        <property type="entry name" value="Big_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23283">
        <property type="entry name" value="D8C_UMOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25776">
        <property type="entry name" value="Ig_VWDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26129">
        <property type="entry name" value="Vwde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034982611" evidence="6">
        <location>
            <begin position="24"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="8">
        <location>
            <begin position="417"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1201"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1332"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1396"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1460"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="1524"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1205"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1336"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1354"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1400"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1418"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1464"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1528"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1546"/>
            <end position="1555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022112071.1"/>
        </source>
    </evidence>
    <sequence length="1571" mass="172480" checksum="769EDB2F5C05BE7E" modified="2022-01-19" version="1">MASDGGTLLILVSLLGCLDVSVGELLTELPYQCSPSGHRVLGNPFRSVSYSATAMSGKLCDKTLDRGWYRFQIFGKYAEMPTECVQVSQCGTDAPMWLDMGGRNHPPPGESARHVACAAWGLGTQRSQQDCCLYSFPITVTNCVDFFVYNLLPARGCNMAYCAMEGREKCVPGQISPDGFAPCRESFPAILGLPIVTPVLFEDVLLKCTFQGLDSGQTSLKGYTVSWYKADSINSFQKVWSEDTFDNFVFINPRDHFHMGDKIFCSVQAFFNETRELKSPAVDSDPFEATIKVSPMSMEIMENGQPHFLMFESTMPIMCADKVAPCSIRVALTTINNEFHLGPDVVLSECFIDFRSRVCLEPRCRRASVLVTAVTDFTRDGRRTSTIVTGAITSTDPFWDGFDPADVEVTVQDVQTAQCYAFTEPHFITFDRKKYDFYKTGTYVLVKSRVREFEVHNRIWNCGGSSDQVSCNCGFVAREDNDVISVDMCDGSVFETIAEVKIRSPLPLSDGVKVKEARNGSKITIEFPSGGFVRADIADWGMSITVQAPSVDFNQTLGLCGTFDGNPDNDFHDTLGETMNMVMKHRQANEFVEQWRLRDGGMFNSVPTTVPFPLQLPSCSCSLSMLAGANSLFPSEDLECIDSINCVRLCTGNEGVSRTDIVQSLDMTSMYNNVVTFPWEPRVKRADTEIERLPKTVATDAHQDSTQEHKITKRFTDFLDLGGDPNFGDFGPESPLFIPDDGNFGSPLIDTYFFYPDHVPTDLEAVVTKWPTTTGITEQQALEICERTIRNSSLGLACGMDTLRTDMFIQDAIEVCLGDIQMTDNIFWSDHAIPLLENQCEAAVVSDRTLWKLNVLELQMDMVPPENIVRALNCPKNCSGNGVCSKLGCVCEAGYSSHDCSQSNVDIPEILRLENNGLCDWRSRSCRRVRVTAREFQEGRAMECHLTRLESSGVERAVFQSSATYINRRSALCHLPSVSGGGTVDKSVTRWEIKMSYRDSQMSSELLFTVYDSHCQQCDWTGSCELKEGACLIDSLCYQRGQVKPEDQCMQCIPDQSVDEWSPNTENQPPVPEDAPPLTFFVGDTIKYQILATDPEGGEVLYAVEAQDNTSDAVVSPDGTFTWQATSQGDYSFAVVITDDCGASALSILQVRVVLCGCLNGGQCVIPTSRDSDSDTTNEADLPRYICDCPPQYSGTLCEVSTEGCVSNPCVHGRCVEENAVYSCQCDEGYTDSICSTPADPCDSQPCYPGVACLTEDSPSGPVFTCGECPGGYTGNGIHCEEIAPSRCRWGCPRRMTCDPSRGCVCREGYAGYRCHQGPNQHVNLIITIPCLAAQCEPECQNGGRCVLPNVCTCKYGYFGPRCQILTCTVNCANGGYCITPNTCKCPLGYSGPTCKLAVCKPSCRNGGRCARPDNCVCLRGFQGAQCQTAICNPSCRNGGTCVRPNMCACPVGYTGTNCAIATCEPRCLNGGRCVKPNKCSCPSGYRGRKCHKAICVSGCRNGGECVKPNVCMCKTGYTGSNCQTPVCRSQCMYGGRCIAPDLCQCRPGHTGTYCQEKTTHSRYKRETDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJS8</accession>
    <name>A0A8B7XJS8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome non-ATPase regulatory subunit 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080392.1">
        <property type="nucleotide sequence ID" value="XM_022224700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJS8"/>
    <dbReference type="GeneID" id="110973692"/>
    <dbReference type="KEGG" id="aplc:110973692"/>
    <dbReference type="CTD" id="5718"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="242"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080392.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52975" checksum="4FBA4A344AF43EB3" modified="2022-01-19" version="1">MDGTGTGDGRLQKMEVDYSEAVDKRIPECQQLAKDGKLSEAIESLLSLEKQTRTAADMHSTARILVAIVSMCYEAKEWGLLNENILLLTKRRSQLKQAVVKMVQEACSYVEKTPDLETKLKLIDTLRTVTAGKIYVEIERARLTMTLAKIKEDQGDITEAATILQELQVETFGSMERTEKVDFILEQMRLCLTTKDVIRTQIISKKINPKFFDSSEASVQEQKLKFYRLMIEVDQHEGAYLDICRHYRALYDTPIIKEDSTKWKEILKHVILYLVLAPFDNEQSDLIHRVAEDKNLEEVTKYRDLLKCFTTQELMRWQQVCAIYEQELKQGSADSSPTNVFSETDQGKQRWNDLRNRVVEHNIRVMAKYYVRITLTRMAQLLELDESEAEEFLSNLVIKKTIYAKVDRLAGIVNFSPAKDPNEILNSWSMNLNELMQLVNKTTHLINKEEMLHQFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKJ8</accession>
    <name>A0A8B7XKJ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110974188</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081333.1">
        <property type="nucleotide sequence ID" value="XM_022225641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKJ8"/>
    <dbReference type="GeneID" id="110974188"/>
    <dbReference type="KEGG" id="aplc:110974188"/>
    <dbReference type="OMA" id="RCHERCE"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022081333.1"/>
        </source>
    </evidence>
    <sequence length="295" mass="32990" checksum="C459950DC96902AF" modified="2022-01-19" version="1">MYGCKICQSASLIEAVSLRCGHQFCKECLLSLLPDPGSHPVSILPEHIAVVICPRCHERCEYTAVHGERLKQQDGGATRAPSLWTDEAAKRRFRKRAQFIQMYRREYDYLNRTSRSRFCSVLEEDNGRASKQCSWDDNLARSSDTFRRTRFDKGDPTKHVKGGLPDLVSQGRGVDDVRAIDHVTGRFITCIIISNSDQTQVSSDAEASSHPIEQQPRSPGPCSPYIARASRREFHRPARSELAPFMDSPSNFLTGTQTTKFCCLDSDIRRGIVAGMFVSLLIAVIIMTSIISSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTH2</accession>
    <name>A0A8B7XTH2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110975375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083517.1">
        <property type="nucleotide sequence ID" value="XM_022227825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTH2"/>
    <dbReference type="GeneID" id="110975375"/>
    <dbReference type="KEGG" id="aplc:110975375"/>
    <dbReference type="OMA" id="TVCCLSI"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF80">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="292"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022083517.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="62396" checksum="A0B84DD2E5723E32" modified="2022-01-19" version="1">MDLPYVDRFLDPYDESLLWIVIVGFIIAFILAFGLGANDAANSFGTAVGAKVFTLLQAIILAAIFETLGSILLGGNVSGTIRGGLFNASVYEGHEELLMVGQLSALASACVWLLIATMMSLPVSASHSIVGASLGFHLVVFLGTGVDWFVIGKIAISWVASPVISGVVSSAIYYVLKFTMLDRHDQLKSGLRAVPFWYFLVFFVNILSILLGVKEVVEATVLGVWLVVLIALGGGLLCALITLAFLVPYTRRKAKGAELRQQHEQAEMGGDQTIKKIRQDFELEVSETQAYGNKCMTTDDENGNTNKRDSDDLDSSGNEAGGETNRRHCNSAISDDDIPHDSEIRGGRAESRMSRVSKVTSTADDEEEDKGIFSVNKNSKDWLSVKDTVAVTTICGPLQGLSACFAAFSHGGNDVSNAIGPLIGLYLIYQEGRISVDKPSPAWILVYGGVGIAVGLALLGRRVIKTIGSDLTPITPSTGFAINLGAAMTVLIASNLSIPVSTTHCLVGSVAFVGFLRARKAMDLKLFTGIVSAWIITLPATVLLSAAFMGLIQHAVPGGCDIQQMQYPPPNSTEIYSTVEMRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTI0</accession>
    <name>A0A8B7XTI0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tyrosine-protein kinase receptor Tie-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083527.1">
        <property type="nucleotide sequence ID" value="XM_022227835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTI0"/>
    <dbReference type="GeneID" id="110975382"/>
    <dbReference type="KEGG" id="aplc:110975382"/>
    <dbReference type="OMA" id="WKEDPYS"/>
    <dbReference type="OrthoDB" id="10059265at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine-threonine/tyrosine-protein kinase catalytic" evidence="1">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022083527.1"/>
        </source>
    </evidence>
    <sequence length="74" mass="8849" checksum="D461AA2B74E727EA" modified="2022-01-19" version="1">MILRGYRMHKPSNCDDETYALMCSCWKEDPYSRPTFTDLVYILSDMADKEIKHTYMDVTRSHLENLHAIQQEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTK2</accession>
    <name>A0A8B7XTK2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ceramide synthase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110975400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022083552.1">
        <property type="nucleotide sequence ID" value="XM_022227860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTK2"/>
    <dbReference type="GeneID" id="110975400"/>
    <dbReference type="KEGG" id="aplc:110975400"/>
    <dbReference type="OMA" id="FRCHNIG"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF58">
        <property type="entry name" value="CERAMIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="99"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022083552.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="40947" checksum="BEA24023543CE6A6" modified="2022-01-19" version="1">MPFSMFNLTANMDLQSIVVFPEYHRLVTVVVPDLWDYYHEEPTHPDGFLGDLRTYCMPISWQELKLPFLLAVVWTLLRMLMTTQVFKPLAVWGKLREDNINKLPESAWRCLCHCITWSFAAYVLLSNYPDIFFRPHTAFKDWKVGNSVPSDIYLVYAIQGGYYLHRIVDTLFHDIWRTDTVVMSLHHVLSLTLITFSYASRYHNIGILVSFFHDFDDIWLEVSKVCVYLKFRNGKKHQNWQTFANICFTILTISWCVMRLYWYPLKVLRNCTPSVARKHAIGFVPFGILFNIMLWLLLALDIYWFMHIVVVLKKVAMGQMKEVDDIRDYDVNKQLMEEEAKNAKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTX7</accession>
    <name>A0A8B7XTX7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110975814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084308.1">
        <property type="nucleotide sequence ID" value="XM_022228616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTX7"/>
    <dbReference type="GeneID" id="110975814"/>
    <dbReference type="KEGG" id="aplc:110975814"/>
    <dbReference type="CTD" id="8666"/>
    <dbReference type="OMA" id="ICQGDHF"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="207"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022084308.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32030" checksum="A87180DA53711471" modified="2022-01-19" version="1">MPTADTNKPISWADQVEAGEQGQQIPDGEVIHEGNVKKVIEYKRNDDGKLLKIVRTFKIEKRKTSKTIAQRKSWSKFGQAADDGEGPSITTTGIADDVFMQFVTAKDDGSNQQEDDTLKKLQSQRLVMCRVCKGDHWTTKCPYKDSLEPLQEKLLQGGGADGAEGADENADTAKKPAGTGKYVPPSARDASGQRKVTPMDSKRDPGTTIRVTNLSEDTRESDLQELFYSFGPIQRIYLAMDKNTGRSKGFAFINFHNKESAASAIRGVSGFGYDHLILKVEWAKPSGSAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUC2</accession>
    <name>A0A8B7XUC2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18">Zinc finger protein 239-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC110975562</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083836.1">
        <property type="nucleotide sequence ID" value="XM_022228144.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083837.1">
        <property type="nucleotide sequence ID" value="XM_022228145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUC2"/>
    <dbReference type="GeneID" id="110975562"/>
    <dbReference type="KEGG" id="aplc:110975562"/>
    <dbReference type="OMA" id="ICGMAYT"/>
    <dbReference type="OrthoDB" id="6591996at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000508">
        <property type="entry name" value="Myeloid zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001792">
        <property type="entry name" value="Zinc finger and BTB domain-containing 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002239">
        <property type="entry name" value="Zinc finger protein 226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000663">
        <property type="entry name" value="Zinc finger protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000771">
        <property type="entry name" value="zinc finger protein 648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF416">
        <property type="entry name" value="FI01424P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022083836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022083837.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35970" checksum="6A0A32A4F37BFC68" modified="2022-01-19" version="1">MEEVHILQVPVLSVPEKPHICDICGKGYLHASKLVIHQRVHTGERPYTCDLCGRSFAEKGSLKNHRRTHSDQKPHACDICGMAYTRRSGLLVHMRAHSGDRPFICGLCGRAFPQQSDLDKHSLSHNNSRPYKCDICEKAFDFRSKLMTHQRMHSSEKPFVCNICGKAYSQRSSLNNHRITHADDKPHSCDVCGRSFNRKTHLMAHQLTHSFVCGDCGRCFSDESDLSKHQLTHEKPYCCEFCDKAFKHSSKLQAHKRTHTGEKPFICQICGRAFSQPGSLKTHQAIHNRNHATQLQLVQQSLCQSEQSHHTPKESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVT7</accession>
    <name>A0A8B7XVT7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled folate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 46 member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 26" type="primary">LOC110975639</name>
    </gene>
    <organism evidence="24 26">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate(in) + H(+)(in) = (6S)-5-methyl-5,6,7,8-tetrahydrofolate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>folate(in) + H(+)(in) = folate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:62501"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>methotrexate(in) + H(+)(in) = methotrexate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50681"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:63724"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Basolateral cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022083960.1">
        <property type="nucleotide sequence ID" value="XM_022228268.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083961.1">
        <property type="nucleotide sequence ID" value="XM_022228269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVT7"/>
    <dbReference type="GeneID" id="110975639"/>
    <dbReference type="KEGG" id="aplc:110975639"/>
    <dbReference type="OMA" id="YTITAAC"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF2">
        <property type="entry name" value="PROTON-COUPLED FOLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="462"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022083960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022083961.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="53524" checksum="F37161F39664A458" modified="2022-01-19" version="1">MPTPSKEETPLLQDGVNGRATWVSVALFLVLQILIFIPGEAVMATLGVQFARSSFARERNFTLPVGSNACGTANTSRELTDIQKETALFSTYQSFLTDLIPVLTGLPLTAASDFTGRRPILLLRCLGPLVMAVGFLVVSFFELSAYYALIGCGVFGVSGGFVLLHSVSMLYVTDIVSPKQRGVALAAIYGIEYAVVYLAPLGLNMLLDALSSFKIVYLIITCFAVMALLWMLPPGIIRESVKKQPVDCRGLTEGIVQGVRDLFVNATGGRRWRLVVILACYAVVSFNLHGFQNTVNLYALGEPFCWTPTLVGVFAFVYGVPNALLAPITVWFMELFVSGYWVIYLSILSGIVEFLLTAVATSNVVLIYGASLGGIFFGISQPVYIALLTRLVARKCHGALFSVHTLVFSLTAASSLVVQSYAYSLAVQSGHAVVLFYVMAVLSGVVFIPTVVVHVLEPKDGFHPDAASEDGSEQSKADSTSGDTDKDTFALAPSSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXN4</accession>
    <name>A0A8B7XXN4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Zinc finger protein GLI4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC110975973</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084556.1">
        <property type="nucleotide sequence ID" value="XM_022228864.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084565.1">
        <property type="nucleotide sequence ID" value="XM_022228873.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084574.1">
        <property type="nucleotide sequence ID" value="XM_022228882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975973"/>
    <dbReference type="KEGG" id="aplc:110975973"/>
    <dbReference type="OMA" id="NMMEQEY"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000019">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000036">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000048">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048420">
        <property type="entry name" value="Zap1-like_Znf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21816">
        <property type="entry name" value="Zap1_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="588"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="618"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="649"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="428"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="662"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="792"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="912"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="967"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="967"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="984"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022084556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022084565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022084574.1"/>
        </source>
    </evidence>
    <sequence length="1335" mass="146109" checksum="BA2AF04FC7675451" modified="2022-01-19" version="1">MMATIKRHEAETSKKRKTTSSPRNTPEEQDKDQVKQDSQQGSSDTPGRGTLSTVCEEPASSTDEDHHQRDSQRAKYLASLRPFPLAPSVHPHHYHHQALHHHHHHHHSPPYLIDPTNGWAALDPRYVHAMDGRLGFHPPIPVDSRTHEGRYHFDSPIHHPLHGHTSGGSPSLSDVSLIRLTPQRGSSADSASYPLYMQHYVDQFRGSPAMSALSHARGISPSGSYGEGAIPPSHPTAMPYHTHLSQHSLIAPEFLSAPPSTAGSIEHPALDVGSIEGSRFSTPRPTDRRSRKRALSISPLSGECLDINAMIRTSPNSLVAYINSSRSSSSASGSYGHLSAGAVSPLSWHPSATPIAHLQQLQQQLMRQRTGLGNPFMPSAIPPPSGAVQHHPAMATLLARAHPSSNTNEETMVPPMTTDILAKHSSRPAVENNTDATHEGHSPQKFLEPNNNDLVTSSLDPADRNRRQDASPNVVSSTCHVDAKKMSPDGHRVGAERHGKGVGIGSEDGTKGLIEEDVPVVTDCEWNDCQARYDTLDQLVQHILNDHIHNERKEFVCRWRGCIREEKPFKAQYMLVVHMRRHTGEKPHQCTFEGCKKAYSRLENLKTHLRSHTGERPYVCEFQGCTKAFSNASDRAKHQNRTHSNAKPYVCKIPGCTKRYTDPSSLRKHVKTVHGPDAHVTKKQRGGDRHDRTPGGAGEGQTRDQQPGSVKSESAESVDGSVVSVGRRSDRPPSVPPSDLHIDVVHDSPITECLTLQHEFSCSPHNDSGVEMTVPGGSLTDLTTIEDDKIQDDHISSNMGPSSQGGRGNGGGGRTRGSALTTLSSQTVRPISPLVCKPSRQRLKVNTPAVNRLAQKVKTAQGLPQLPQINTRRGAIVNTSSEFKPKDRNIIKLQAEEMGRCDSSQSFIGSLDNLGARRGSNGSTVSSYYSSRRSSEASPFPLSQFSSRRSSGASTYLSSRRASGASSQFSSRFGATSSNFDPISPGSSRRSSGAMSGMNGPTGLPGLTLEEQRRLQAKYDQVTGQQNSWGEDKFAPSPLPGYNGNRHGSFPSRTPLPHEVPGVGIRRASDPVHQRQQEPVLHRYNSLTNINPHNPLPIPQNMSSLKQRSRPMEMPPVISNQWQDMARESAMGQHSGTMDMINEDPTGDMMSMQNAVYQPMIPSNQNRGYNNGYAEPKMMTGGYVDSNDMMHSILGNVNEQYQPNQMQLNEAHYIQLQQQQQQRAYQNSMPTSMEMSPGCNQVSSTVDHPYDQPSIPQMDCDDPVASGLAALSADGLDNVQPLIPNLVSPTDLMNGMGCESPMVPNVNPVSNMVVNDMSSMLTSLAEENRFLNMMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXN7</accession>
    <name>A0A8B7XXN7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Scavenger receptor cysteine-rich domain-containing group B protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110976227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085017.1">
        <property type="nucleotide sequence ID" value="XM_022229325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXN7"/>
    <dbReference type="GeneID" id="110976227"/>
    <dbReference type="KEGG" id="aplc:110976227"/>
    <dbReference type="OMA" id="PYWDIND"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004720">
        <property type="term" value="F:protein-lysine 6-oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000032">
        <property type="entry name" value="Si:dkey-14d8.20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050912">
        <property type="entry name" value="LOX-like_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817">
        <property type="entry name" value="LYSYL OXIDASE-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45817:SF9">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034998774" evidence="8">
        <location>
            <begin position="20"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="33"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="9">
        <location>
            <begin position="140"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="71"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022085017.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="39531" checksum="A1DBFB8C0E8ACF0C" modified="2022-01-19" version="1">MVQWLFGVTAVVLLYGVTAQSNVTQGVNTGFSVRLMAGSGPNEGIVEVTQEGKRGPICNPYWDINDATVVCRQLGYPLATLASTGQRFESRIYDTHLEAVSCQGNEYRLDDCSRGSWVSQPCSDRDTAAVICSSIGEFSVRLMGGPSRFEGRVEVYHIHAGTQPMWGTICNDYWDIYDAQVVCRQLGYGNAKAAVDDGDRLYGMGSGPVLLESVTCYGTESTLASCLTPGWHVHNCGHNEDAGVICEYADTSYVWLSPLAVTFIVIGSLLAFCVVIGCIVCCISSVTKKKQRRTASSPEPPVSFAASNQAATVETAGASPGYSLPIQQFQPPPGYVLTTTTASGGTPGFTTITPMPPPPPYAETPNAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZQ5</accession>
    <name>A0A8B7XZQ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Integrator complex subunit 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110976959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Integrator subunit 2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086389.1">
        <property type="nucleotide sequence ID" value="XM_022230697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZQ5"/>
    <dbReference type="GeneID" id="110976959"/>
    <dbReference type="KEGG" id="aplc:110976959"/>
    <dbReference type="CTD" id="57508"/>
    <dbReference type="OMA" id="IISNYPH"/>
    <dbReference type="OrthoDB" id="70899at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026236">
        <property type="entry name" value="Int2_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029321">
        <property type="entry name" value="INTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28608:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14750">
        <property type="entry name" value="INTS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02105">
        <property type="entry name" value="INTSUBUNIT2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086389.1"/>
        </source>
    </evidence>
    <sequence length="1143" mass="127598" checksum="F7D8F936B55FE531" modified="2022-01-19" version="1">MSKRFELSPAAFEAIQNVDIEQIARMDEGSIRALLPCLVRMSLCAPLDVSQAWVEGRKQILRVLSGLEVVNSIVALLSVDFNALEQDARKELQMRHKLGETENLLTSNIQHGLALEFERSDPASRLRLLISELLFVSSQIKDTTDFVRRPCELFESEVYLEEVSDVLCIAQAELPSLLSIDKMAESLLRAQYGPILLCRLVANVPDSFFQVCKNLIVNGERQDEDSYGGRRRTQTLRMLATMNPSQALSIRALAIDQCKLPGLAVALSLDHDTPDQSESRMSDVVGFISGLLLGSNSGVRNWFAQFVRNGQKHKADASTSILQALRMHLLQQLKAIIPSEEFHGNLPERQVVQASAVMRLYCALKGIAGLKFSEEESKQLLRLLSSHPLPTPSGIHFICLGLCMLFACPSLISQEDESVVIDWINWLVREGPMFERESGVSASFSEMLLLMASHFHGNQVHAIIDLVCSTLGMKIPIRPNSLARLRLMFMQEVFTEQVVTAHAVTVAVTPDLSGSISGYLPIHCVYNLLQNRAFAKHKVPIKDWIFKQICHSAPPLHPLCPPLLEAYVTSVVVPTQSGTKQYRNEPLTEREILSVYKTSNVSLLRASVLAEDPGVAGEGGSGLTVQLLMLYYLLLYEDCVLSNMKTLVMHNERPQSYSSKLTSQIPIKYLLHEAQRHQPDYAGLYPSLLRLLATHYPHLCLVEDWLGEELMEEEVGGRERKKRQGGAPASKCSPARLRNALQHAREDPSESLLLLRRLCQSEPHHLMDFAEVLVDSLPGLLGERVPRQVVTLAVKLWRMLNTVMLRKLRVMTVNALVCTKPVVPFTEEDITLDPLIVLRCDLRVFRCPPILDVVMQMLTAYLAASRAFLATHLQSSPSILRRPEQGLTPQPTDPEREELKSALIAAQESTAVQLLLEICLPLENEEEVSSKLSLLCEVQCLVCSQLHQMFIADPNLAKLIHFQGYASELLPITVAGIPSMHICLDFIPELLSQPQTDKQIFAIELVSHLCLQFALPKSLSVARLAINVMSTLLTVLPSESLCEFFLPTLPSLVRICQAFPPMYEDVTSLLTQIGRMCMSRLAAVNSPMRAGTNSSSFGLFTSKGSQQRPEDLNLRNSDRVLHMAVENTFRDIVKFAVVNKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y044</accession>
    <name>A0A8B7Y044_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein KIAA1841 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110976698</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085885.1">
        <property type="nucleotide sequence ID" value="XM_022230193.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085887.1">
        <property type="nucleotide sequence ID" value="XM_022230195.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085888.1">
        <property type="nucleotide sequence ID" value="XM_022230196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y044"/>
    <dbReference type="GeneID" id="110976698"/>
    <dbReference type="KEGG" id="aplc:110976698"/>
    <dbReference type="CTD" id="421196"/>
    <dbReference type="OMA" id="SWVVAKI"/>
    <dbReference type="OrthoDB" id="550012at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045902">
        <property type="entry name" value="SANBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021777">
        <property type="entry name" value="SANBR_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20946">
        <property type="entry name" value="SANT AND BTB DOMAIN REGULATOR OF CLASS SWITCH RECOMBINATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20946:SF0">
        <property type="entry name" value="SANT AND BTB DOMAIN REGULATOR OF CLASS SWITCH RECOMBINATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11822">
        <property type="entry name" value="BTB_SANBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT and BTB" evidence="2">
        <location>
            <begin position="153"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022085888.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="70226" checksum="7D00639CA709BA7E" modified="2022-01-19" version="1">MIRRDSPSRAVALDLMLRTFMNSSDFNNMQSKNWEAIAKLIPGTTPQECAKRFQELQSAAGDLSPVGDFTGLAARGKPAPRGRPGSATLKYQRPLATSTSEEKRGDQRQGGKEVQKELANNNSNQDAEESNDKKRQQESHKRKVGPDSYGPNMVIHVCDEAKNVKKDFTCPRDLLVTEMRYFAEYLSSDTQRWEEVDISVHCDVQIFDWLMCYVKRNCPGSQTRQTPNLEASNVISILISSDFLKMDSLVNECIDFCHKNMSAIVATPCNMNCINDKLCTRIADLFTDLEVDEVKDRKDKFKSKLFSKKIEAMFEGTKPATTLYRCLYCRRLLTEELRSKLKCISTRMSIDRQGNVVYHHQRDPAWDVNDYILALRSELKSWREVYWRLWATVTHLPCSRCKQVFPCSELGHCRFHPEPPKFDNSSSSTGTYLCCQQKTLRFDPLNQNTGCQVRDHIVMIPSKDESSKADGLSHHQGKAGRDDAQSLDILLERKEFMCIPPKSPEQERWHEVNIFRSEEALCGLAEEGIGVKGQLQHIFPDDHLPLNNQLDDRGRDLVASSSDFDSSDDEVGDEEIHRVSKHRQKHLVRKMSSKSSMGREKHNSLMSVDSAASNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y063</accession>
    <name>A0A8B7Y063_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 136-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110976712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085907.1">
        <property type="nucleotide sequence ID" value="XM_022230215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y063"/>
    <dbReference type="GeneID" id="110976712"/>
    <dbReference type="KEGG" id="aplc:110976712"/>
    <dbReference type="OMA" id="SERDCEW"/>
    <dbReference type="OrthoDB" id="506011at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042512">
        <property type="entry name" value="TLCD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898:SF1">
        <property type="entry name" value="TLC DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31898">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="32"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022085907.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="25738" checksum="55B2781894536962" modified="2022-01-19" version="1">MELSPAAILFIVVTSFTLWSALHGLQCLLLPHQTNEWNYRVVVTVHSVTMLVLGAAFELFIDPWRFPHLVSPPGQPSNSKELATLAVCLGYFIYDSIYTLYSGKTVSMNVHHAVCVAGLCVALTSAVSGAEILFCLFLGELTNPLLQVRFFLRAAGMTKHILYEVNDVLFLVTFIVIRIGLGSYLLYCVLMDPVLHLFYKTGGIALHLISVVFMGEMLTVSYKKYIQKKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y329</accession>
    <name>A0A8B7Y329_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DDB1- and CUL4-associated factor 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087584.1">
        <property type="nucleotide sequence ID" value="XM_022231892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y329"/>
    <dbReference type="GeneID" id="110977611"/>
    <dbReference type="KEGG" id="aplc:110977611"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF39">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022087584.1"/>
        </source>
    </evidence>
    <sequence length="234" mass="27172" checksum="527DCA4DD41A7B17" modified="2022-01-19" version="1">MRDASPESPSITCSESDSDDDLILRPPRLRRRHRRRESEETRRPRPPSVTESRLRELFLARREAREKGEIREKGEMQLDNIDMPEVKMVYKGHRNSRTMIKQANFWGSNFVLSGSDCGHIFIWDQHTAELVMLLEGDRHVVNCVQPHPFDHWLATSGIDYDVKLWSPTAEMASVPDDAAEVMRINELMLDETRDTITVPPSFMLRMLASLNHLREERRRSRESPSSSDSTEDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y391</accession>
    <name>A0A8B7Y391_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110977193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977193</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086785.1">
        <property type="nucleotide sequence ID" value="XM_022231093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y391"/>
    <dbReference type="GeneID" id="110977193"/>
    <dbReference type="KEGG" id="aplc:110977193"/>
    <dbReference type="OMA" id="ASIGEWH"/>
    <dbReference type="OrthoDB" id="10030431at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034998776" evidence="3">
        <location>
            <begin position="23"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="LamG-like jellyroll fold" evidence="4">
        <location>
            <begin position="133"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022086785.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="31477" checksum="2CB8A707A5DA48DC" modified="2022-01-19" version="1">MATFRMVYVALAVVALSALVSASTSSVSVNIGVSEAAQCAYVFSLDELDDCTCPSLEEAMRRWLAQRQTPVVSKDLVAHYAFEDDLSDSTANRRNGSANRRVNYAVGKCGKAAVFDGSTKVDVDAFRSYPWGSQFSVSVWFKRTGSKDTYQGIVTTGYHTTGSWEIRMKGNQNLGGGVVTANNAPTWNYADLTASIGEWHHAVMTYNGSQLLFYLDNQLQSGDDDCCRGDIISKKTPLTIGQAGVGWRGEFFVGLIDEVKIFSKALSASEVDKMFNDPCFIGDVSPCHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3V8</accession>
    <name>A0A8B7Y3V8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CAP-Gly domain-containing linker protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110977758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087873.1">
        <property type="nucleotide sequence ID" value="XM_022232181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3V8"/>
    <dbReference type="GeneID" id="110977758"/>
    <dbReference type="KEGG" id="aplc:110977758"/>
    <dbReference type="OMA" id="KAESAMI"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="192"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="314"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022087873.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="41489" checksum="77FB201571DD70A2" modified="2022-01-19" version="1">MTLLHYACKAGCDGVGERASATKLTSLLLEYGASPELRSRWTDMTALHYAVFFDIVPIIRLLLKSTEFKDLESRCGEFDNGTPLHIAAANGCLESVRCLLQLGANSHAKDTQGRMALHCVPDSSDISRPGWEATAGKLRQLLHPDSQFTRPKYSPQNYDDVPSKVLLASLGLGFGDRVYLGDSKAGTLQFYGTTQFAPGMWAGIELDEAIGKHNGTVEGVTYFECPQKHGIFAPLSKVSKFVVSPRPSTPRSGGGCTAAVYHGKIDVSHVSPKVDTGLRSRTFSAAGKFEDVCVGDRVSIAGQAPRHGIVQYSGFTQFAAGWWYGVELDGPEGKNDGSVAGVRYFTCRPQYGLFAQPSKVTRCNNSRDSSISSQAVETNAADRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3Z1</accession>
    <name>A0A8B7Y3Z1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Tctex1 domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110977430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087257.1">
        <property type="nucleotide sequence ID" value="XM_022231565.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087258.1">
        <property type="nucleotide sequence ID" value="XM_022231566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3Z1"/>
    <dbReference type="GeneID" id="110977430"/>
    <dbReference type="KEGG" id="aplc:110977430"/>
    <dbReference type="OMA" id="MEYENTY"/>
    <dbReference type="OrthoDB" id="10248487at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21451">
        <property type="entry name" value="DLC-like_TCTEX1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF65">
        <property type="entry name" value="TCTEX1 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022087258.1"/>
        </source>
    </evidence>
    <sequence length="183" mass="20799" checksum="830221C676FCA9A5" modified="2022-01-19" version="1">MTAKVESASAQMATKIAQEAQAGLARSSLFDMAPRPHNTGSKSCVSLAVAPVHDDEEEEFAPRQKVEYENSYRMEPPKRFVPERVKQILCDTLEKELANMTYEPVSCSTQCKSIAQEVKLRVRALDYQRFKLVCIVNIGEKRDQDVRLGSRCLWDANRDNFACASYENQHIYATATVYAVYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4C7</accession>
    <name>A0A8B7Y4C7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat-containing protein 73-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110977856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088039.1">
        <property type="nucleotide sequence ID" value="XM_022232347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4C7"/>
    <dbReference type="GeneID" id="110977856"/>
    <dbReference type="KEGG" id="aplc:110977856"/>
    <dbReference type="OMA" id="CKPRTLL"/>
    <dbReference type="OrthoDB" id="9822052at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042795">
        <property type="entry name" value="Wdr73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46947">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46947:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022088039.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="48877" checksum="88F37A3C45FEA3E3" modified="2022-01-19" version="1">MDTIEDGDDFFDDWIIKSMKSYRHLHMFDLPQPTCVIEWSENDGIFVAGCSSDSRNEILEMSIPAKLRWESSSKGAGLTRDRDFKMLRGGFSEKAIHCLTYLVGTRPRLIVTGSHASSHLDVWQLDTETSDVIKKLHTVPGQGTEGGGIRSVAQRPGHRGQVAFGAMMSNLQVADVETKEVIATDFGKVEGGLEMQFLNNNELVTCSTQNGLVNIHDLRTTSSQSVLTDQSMKLSSAESKHCSLDEGTTQTYNKTISQSGSGLDVAVDESTNQNISKKGKASWTFDLSCSPVPHLDPAGGEIACKRPKLDVSMAMVVSLCSSGELVIRDLRNLEMPLQHVQLGDEKRQPREMETLTVRWCPTEKNLLSVSGLNGCVDIYDISTWQQSSTSPPNVQPIFSHEGHMTGESANQGGGILCHAWHPRHPCVVMSSGSNGSLHAWDWSAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4G8</accession>
    <name>A0A8B7Y4G8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977521</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087442.1">
        <property type="nucleotide sequence ID" value="XM_022231750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4G8"/>
    <dbReference type="GeneID" id="110977521"/>
    <dbReference type="KEGG" id="aplc:110977521"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087442.1"/>
        </source>
    </evidence>
    <sequence length="317" mass="35462" checksum="4E165148DDD280BD" modified="2022-01-19" version="1">MLEINNRAPPCITMEETHPPAGSRKLSIKQGPLEDRPSLSPRPFAETRRVGYYIADPETPTEYSNMAKAYACVLLLLGLVAAVEPKCCFPLMESWMTNIVAGLVYKNGEVMTETATYGRNTIDGLQGSSKFFTNIMTGVVSTVRKVQKYQPGVNATFNTWMIYDEKECTIELKPSAIQNCVPEFAELSPIWYGNLSQPLDIMRRYSVTPVGARPGDRDLLEKTLFVAPGCSLANSLKIDINPTKKFASLVNYANFRVITDTSEFADMFDLPDFCPREVPTANKPEAAQPKPEPRAEPQPETKNERARDALRNSRFFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y543</accession>
    <name>A0A8B7Y543_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein dead ringer homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110977286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022086961.1">
        <property type="nucleotide sequence ID" value="XM_022231269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y543"/>
    <dbReference type="GeneID" id="110977286"/>
    <dbReference type="KEGG" id="aplc:110977286"/>
    <dbReference type="OMA" id="GGQSEWT"/>
    <dbReference type="OrthoDB" id="10044343at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16881">
        <property type="entry name" value="ARID_Dri-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000007">
        <property type="entry name" value="AT-rich interactive domain-containing protein 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045147">
        <property type="entry name" value="ARI3A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023334">
        <property type="entry name" value="REKLES_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348:SF0">
        <property type="entry name" value="PROTEIN DEAD RINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51486">
        <property type="entry name" value="REKLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="7">
        <location>
            <begin position="299"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="REKLES" evidence="8">
        <location>
            <begin position="473"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022086961.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="65711" checksum="3F1964EB477AB19C" modified="2022-01-19" version="1">MERTGEVLEQGRSNGVQPQHRILPPKHHHPFYSQAMTSTFSVSHARRQEILRRLEMMNGRDDYDSDEMDGELNYGDEEELEEDKLTAEDKEIDLSLRHLNTSKLSPNPHPIFPPRHYKTSPPRHPKTPPPVNGGPVHYESHRRRKSLSPTSAIREYAAQGDRACDRSSLKRSSTERSLERPSVEKSPSESPSSPETSERFSQGRGCTERTPFERCQSERCSSDDEANSLSCSNQPEDYSIKLEKPSDSSLYSEDENNISEDTKPVSPTVFKEAGKPGVGGQSEWTFEEQFKQLYELSDDRKRKEFLNELFSFMQKRGTPVNRIPIMAKQVLDLYELFNLVTSKGGLVEVINKKQWREITKGLNLPASITSAAFTLRTQYMKYLYPFECEKRKLSTPSELQAAIDGNRREGRRQVYTTNATGFGLSPHSPTLPTMIPHPSVIPHNVRDSPEFEEERDARDFPFSRSFMQPRMAKHPMKHALYEEPLTPPPKRPLLTDEQHHRYLLQQQQHQMVPPAAHIKVTSNHAQRDTGLPLFELRGDNSLIVSIELNGVLYQGVLYPRGTPLHVLTNRATGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y574</accession>
    <name>A0A8B7Y574_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110977685</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110977685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087692.1">
        <property type="nucleotide sequence ID" value="XM_022232000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y574"/>
    <dbReference type="GeneID" id="110977685"/>
    <dbReference type="KEGG" id="aplc:110977685"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022087692.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15391" checksum="B905445EAB570071" modified="2022-01-19" version="1">MQPTPTDENSQSAGDTVSTTTFIAVVVPISVVTSLLCVILLVFWRRTLLQSGQLPNNRHDSREVMIVNNTFSPDHLTSTPTPPDVPRRPAKESYFSSVESSAYYVAPAPTGKAQATGNKASSIYEYIEPKHTDYYLELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5S4</accession>
    <name>A0A8B7Y5S4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Orexin receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110977687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087700.1">
        <property type="nucleotide sequence ID" value="XM_022232008.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110977687"/>
    <dbReference type="KEGG" id="aplc:110977687"/>
    <dbReference type="OMA" id="YECADIS"/>
    <dbReference type="OrthoDB" id="6052219at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238:SF47">
        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24238">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="24"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="205"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022087700.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47820" checksum="26B4DBA172B18A4C" modified="2022-01-19" version="1">MYLDSVWWFRVILESVVVIIGIPGNLLIIQVYTAKKNKVTPHIFIIGLTWADVSVCLLRIITLVQLFPPLDTLRSSNEFFCRVQPSIDAWPKYTSILLTSAVAVDRYLAICRPHGRRLTVRRARHVVLGCFAVSVLVTLSYLFTYGVVTLEDGSQACLFILPSAVISAQFIILMISFVASVILIVVLYIKIYRTVNRMAKVRPGNKVRREARQPTCRPSQDDSTAIAEGITPKQLKTLTSGTNREIPKVKPAYDPEDRRSPPQPEQGNPRHKGVTKLAWTGDQQEMKELPILDPLPKTTAPSTSALNATRDNPSSTVPGAHSTAADETNRPTAQTFHKRTTLMLLLSTVVFVVTLLPLCIILTLYPLIVPFLQNQTVRFCVNVASYLNVINNAANPILFSYVNRKFREEMKRSLRKLCCQGCRFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8J4</accession>
    <name>A0A8B7Y8J4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">EH domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110978194</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088675.1">
        <property type="nucleotide sequence ID" value="XM_022232983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8J4"/>
    <dbReference type="GeneID" id="110978194"/>
    <dbReference type="KEGG" id="aplc:110978194"/>
    <dbReference type="OMA" id="LMIGQYS"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000147">
        <property type="entry name" value="EH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000038">
        <property type="entry name" value="EH domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040990">
        <property type="entry name" value="DUF5600"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF31">
        <property type="entry name" value="AT21416P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18150">
        <property type="entry name" value="DUF5600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="55"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="11">
        <location>
            <begin position="447"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="479"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022088675.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="61936" checksum="B53521C5116397C0" modified="2022-01-19" version="1">MFSWLNKDENRRKQPHTYKSVVEGLQELYKSTICPLEEHYKFHDFHSPPMDEADFLAKPLILLVGQYSTGKTTFIRYLLEKEFPGMRVGPEPTTDRFMAIESGDSDSVIPGNALVVDPKRQYRALGKFGNAFLNRFQCSLTPSPVLDSITIIDTPGILSGEKQRVDRGYNFVGVLEWFAERADRIILLFDAHKLDISDEFRRCIEALRGNDDKIRIVLNKSDMVDHQQLMRVYGALMWSLGKVINTPEVSRVYIGSFWDKPLHFDMNRKLFEAEELDLFRDIQSLPRNAALRKLNDLIKRARLAKVHAYIISTLRRDMPSMFGKESKKQQLINNLADVYKEIERSYNISAGDFPPMKRMKEVLADMDFTKFHQLKPKMIEKLDQMLQGDMTRLMQMVPQEEAQKPSDGMGPIRGGAFVGNETPFGAGSGEGADYGKGELNEWVVSEKKDIYDRLFDSLGPTDGKLSGTKAKEQMVKSKLPNTVLGRIWKLSDVDRDGMLDSEEFALAQHLISIKLDGHDIPEALPRHLVPPSKRRFALDMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8T8</accession>
    <name>A0A8B7Y8T8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mid1-interacting protein 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110977928</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPOT14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088156.1">
        <property type="nucleotide sequence ID" value="XM_022232464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8T8"/>
    <dbReference type="GeneID" id="110977928"/>
    <dbReference type="KEGG" id="aplc:110977928"/>
    <dbReference type="OMA" id="EEGNAWK"/>
    <dbReference type="OrthoDB" id="5951908at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046890">
        <property type="term" value="P:regulation of lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053719">
        <property type="entry name" value="Lipogen_MT_Stabilize_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009786">
        <property type="entry name" value="Spot_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315:SF17">
        <property type="entry name" value="MIP21584P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14315">
        <property type="entry name" value="SPOT14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07084">
        <property type="entry name" value="Spot_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022088156.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20161" checksum="93F3B4840CC2E4BC" modified="2022-01-19" version="1">MELNLADNERMSHSHSNHSILSVMKGFIDAVNEMDETVLIPSRLMDMQAEPKTLALQQNAASSTKSQDMAVIPASCAQDSVSLHACYAMLKAVKSELVRGPIPEEDRLAADDDDDDKENIGTDKNRSLEEATARAFREHLIGLFSILQQLTNVSKKLTTKYQEELGDYQSCFKPKSSSSLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8V8</accession>
    <name>A0A8B7Y8V8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Collagen alpha-1(XXII) chain-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110978742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089669.1">
        <property type="nucleotide sequence ID" value="XM_022233977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8V8"/>
    <dbReference type="GeneID" id="110978742"/>
    <dbReference type="KEGG" id="aplc:110978742"/>
    <dbReference type="OrthoDB" id="6161718at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048287">
        <property type="entry name" value="TSPN-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1082">
        <property type="entry name" value="COLLAGEN TRIPLE HELIX REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00210">
        <property type="entry name" value="TSPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Thrombospondin-like N-terminal" evidence="4">
        <location>
            <begin position="63"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="846"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="869"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="886"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="952"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022089669.1"/>
        </source>
    </evidence>
    <sequence length="998" mass="100853" checksum="A10209B2CEA8C85A" modified="2022-01-19" version="1">MRGKCNSRWPVRPELCVISMFLAVSFYRNGVTARVQLPLYLAETLETLECPDDIRIGENDLPGWDVIRLFTLDDQASGIKEIPGSNEYQTAYKINKKSDLVRFPTSALFPDGLPDEFSFVSTFRMSPAARREDWLLWQIRDPAKVPQLAFRLNGEQRALQIVYVDTERQLQSVSFRDVEELFDGDWHKLHIIILNDRVTVFVDCKIVSSTLISPRGVVDYSGKISIGRTLQDDQPVPFDLQWMIIHCDPSRPERDNCDELPPKTGPTPGTCEQVCPPGPAGPEGPTGALGAPGRPGRDGDPGLPGPAGPVGPRGVDGFRGSPGSSGPPGPPGPRGDPGPMGIDGVNGSPGEKGDIGEPGLIGPVGTPGQPGFPGPQGPQGPPGDLGSIQDLITELGLLKGEQGSPGLPGLNGVPGENGRMGPRGPRGPTGQAGLNGEDGTKGAQGARGPEGPQGRPGPPGPPGTPSTGSEFTQQPTAVVGPPGEPGPPGPRGIQGPQGESGERGNIGRPGPPGAKGEDGPQGPPGKIGERGSPGSQGLLGQPGPRGDKGEAGIQGLIGQQGPPGTVGPRGNDGPRGAPGPIGLPGPPGPTGSRGAPGLFGMKGEKGDTGDQGPRGTDGIDGQKGDRGEEGLPGERGVPGPMGTAGPIGDPGEKGESGFPGRKGDTGSIGERGFPGPAGPKGQTGIFGPEGPKGERGQPGIQGIKGQRGPKGRDGGPGIVGPPGLKGSMGIMGSRGPRGDPGPKGERGPPGPKGTAGRQGEEGKPGPIGPPGLDGQKGLRGDPGANGQVGPGGPQGPIGAPGVKGEAGPRGYQGDRGEPGAPGFTPSDDDIAKIVERVLQSQMQNIASRLTGPPGPPGKTLRGNPGLRGTPGPSGNPGNQGSPGEPGRPGGPGPRGDPGLSGPPGQRGARGDKGSKGYGRRGFPGHMGLQGIPGNPGIGKDGKDGPQGPRGPQGPAGRRGPSGPQGAAGYCEYCNYPGAQQLVNPYPYQPYVDLNNKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9P9</accession>
    <name>A0A8B7Y9P9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110978527</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089282.1">
        <property type="nucleotide sequence ID" value="XM_022233590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9P9"/>
    <dbReference type="GeneID" id="110978527"/>
    <dbReference type="KEGG" id="aplc:110978527"/>
    <dbReference type="OrthoDB" id="10068710at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33480:SF1">
        <property type="entry name" value="TYR RECOMBINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089282.1"/>
        </source>
    </evidence>
    <sequence length="984" mass="104897" checksum="73058C7DF0EDF41D" modified="2022-01-19" version="1">MATADPGPAATDDHASVEHVRQVDSDTNCSPGGSRPEAKSCSSLQSLMATADPGPAATDCHASVEHVRQVDSDTNCSPGGSSPEAKSCSSLQSLMATADPGPAATDDHASVEHVRQVHSDTNCSLVGSKPEAQSCSSLQSLMATADPGPAATDCHASVDHAHHVDSDTSCSPGDTSTGAQGCHGPLLTLVASTNPSLTATNCHASVEQVDRVAFDKKCRFDISSGEYQACSLLTLLATDDPSPTSTAKDRHASAEQIQQVDFDTNCSYDNTCLKAKACPPLITLTATTDPSPTVIGCHTTVQLDCEVDSDATCIPDNFNPEAQPCLSLQSLMSTAEPSPVVTDCHASDESVCQVYSDTNCGPVDSSPEDQACSLLQSLMAAADVSHPPTTFHDSVGMVVSVSQVDSCSNSVCATTCLSTVFNLSSNCQTLRQSSSSSVLMDEFNCSDISPTSTGCMKMKNVRLPECETTCTCTLPSCTSPVLKWVSCKPIPAVIPISLLHQGKSLEVARSCFTSIVLRGDLVATSSTTARFVDTVSTTAVLPVSDSPLTKDCVSLCDIVPTRNLASAPSGELNCSLPSGGSNSVSGSGEVAITSLVCSNSSSPATCSFVSHVPSSDFHCSDHDSDSDYVPESESSTGGDSNTGDIAVPASRPPTRANMDLQGCVQMTKVKPGGKRVWNKVDYCLYCGIKQAKVARHCLLRHEDKVMVKEIQALELKSLERREKITELRNKGNFHHNLLVWQSGTGEIVPRKRPIEDEAASNYLPCEFCQGCFKREGLWKHQIKCAQKNKVTKKKRIQSMAKMMIPSLTGTVSESLKKNVISRMRADDVTSVVRRDPHILNFGTKMIRDHPEAHQALPISQNMRDLAKLVVATSRVDRSVTSIRDCLNPQKFDTLVDAVKVTAGYCADTNTYKTPSFARNIGYSIDKVAASGKSSSIKSENTELFEAISNFQQLKNAECTSEVVTLARHNLDSRKLNKPHQTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAD4</accession>
    <name>A0A8B7YAD4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">39S ribosomal protein L15, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110978550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089330.1">
        <property type="nucleotide sequence ID" value="XM_022233638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAD4"/>
    <dbReference type="GeneID" id="110978550"/>
    <dbReference type="KEGG" id="aplc:110978550"/>
    <dbReference type="CTD" id="29088"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="7">
        <location>
            <begin position="115"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022089330.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="35583" checksum="52E0FB3AE9B2C68B" modified="2022-01-19" version="1">MDGTTFQMKVTPKRVLRLINMATSSSGTQRALELLRNLPRVALNNIRDNPGARTKHKVRGRGQHGGDSSGRGKSGQGMRGTKPRIGFEGGQTPFYLRIPKYPYYKGHRLKREYLPVSLNKIQHLIDLGRLDPEEPIDVNSLVNAGEVNIDIYKKQYGVHLTEEGADTFQAQLNIEVQWATELTIAAVERNGGVISLGFYDLQSLDALAHSLHFFNQGKPIPKRALPPKDIVPFYTSAENRGYLADPDNIRRERAALAEKFGYALPDLSSDPRRGMLGMRKDPRQIFFGLQPGWIVNLTDRTVLKPIDEKLVEYYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBZ4</accession>
    <name>A0A8B7YBZ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110978882</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110978882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089895.1">
        <property type="nucleotide sequence ID" value="XM_022234203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBZ4"/>
    <dbReference type="GeneID" id="110978882"/>
    <dbReference type="KEGG" id="aplc:110978882"/>
    <dbReference type="OMA" id="SYSWRIN"/>
    <dbReference type="OrthoDB" id="10028801at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034680591" evidence="3">
        <location>
            <begin position="27"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="23"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="227"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022089895.1"/>
        </source>
    </evidence>
    <sequence length="933" mass="101942" checksum="7E7B5C8548E4A1B3" modified="2022-01-19" version="1">MTSFHFVGFICVVLALFVDHPLPAEAQYAFREEPRDSAVQLGDTATLRCAVDNRKTAIVAWWSDGLGGFISQNHQLKQFSTDTDKLERYSITGELALGEFNLQIRNFSSSDAGTYRCHILASAERETVVKYSRDATLRVAPYDPRCYVESVSPVPMIGDKVALVCESRNFDYSDDLTWMYAARRILKGNITRTPTVRNVVTHVLTEADYDARFMCFEQQRRTCFLIPLRRYISVLVQTAVAQPQLGDTLTYRCVADNDLTPLSYSWRINGVDVAVADDTLTVGPLNASHNGSVIECAVKHSSGFKGNDNITLRIQPNEGGTRTTPLSTTTEDSSSQRSAENVPTDFHRSNVWPTTGPTNPILLDQRDTSKSQEDGWGGLLMPFVICASVVGVLLTTVIILLTVFLNRQRASNRRANSAAKTSDSTGGPVSDCVPLDLVANRDVNVNGSPAISVGTLKGFKNPAGCGSVDTFEIDLDPESPPEYYTLEHNYYEATVGKLDSTNCSDNHDSGFDGIEVSETITPDSELTARNRKFSFGSSPPPHIPSSSSQPSAPVAIPPEFEGSNSECLVAAYAVTDVARSSPPDTKRSNARGGSLKRPLPARPTDSGYRSPGVVLANERPFRRVGSLKSIDEPVVGALARSNSLKRPLPATPRSVSLRTPRTPDPYRNPSPLFTRIPPFLSSDSPGATPAVTSTSETKTDLPKETDKPQKSKVPQKYPKLTVPFERLSAATSVSEGDYAEIDMDQEQEATERDSLMSNSSIMGDNAGSLGDNETRSTVDVEDLAGAEVNGGEADYDTVAESDGEEIDTDHMEKNALAALISDGKQPWSDIGNSDKVEEFQEVHLPDEIPEIPDELICQKSPMYAKVKRQNSQEFPLSDTDINEENHTELDNVNSQLCSVNISPVDGHFEMDINNLGQERALLENAEQPYALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YC40</accession>
    <name>A0A8B7YC40_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18 19">Potassium channel subfamily K member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18 19 20 21 22 23" type="primary">LOC110979372</name>
    </gene>
    <organism evidence="16 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090804.1">
        <property type="nucleotide sequence ID" value="XM_022235112.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090805.1">
        <property type="nucleotide sequence ID" value="XM_022235113.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090806.1">
        <property type="nucleotide sequence ID" value="XM_022235114.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090807.1">
        <property type="nucleotide sequence ID" value="XM_022235115.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090808.1">
        <property type="nucleotide sequence ID" value="XM_022235116.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090809.1">
        <property type="nucleotide sequence ID" value="XM_022235117.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090810.1">
        <property type="nucleotide sequence ID" value="XM_022235118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YC40"/>
    <dbReference type="GeneID" id="110979372"/>
    <dbReference type="KEGG" id="aplc:110979372"/>
    <dbReference type="OMA" id="CIAYAYF"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF334">
        <property type="entry name" value="FI03418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="182"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="321"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022090804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022090805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022090806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022090807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022090808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022090809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022090810.1"/>
        </source>
    </evidence>
    <sequence length="529" mass="58953" checksum="9BDF1AD845F5921E" modified="2022-01-19" version="1">MGAGRRVLALLVATFAYLFIGASIFSAIESAHEEQIRLDLYNRLEAFAERNPCVNVSEFRDVLSEVWYAASIGMERMVGQENYTLPSSRWDLANAFFFSATVITTIGYGHLSPATSSGQNFCIAYAYFGIPLMAVLLSEISSKWKQRLINVGHNLDTRLANALKRDRVRRVAIAILLVIPAYVIVIIIPATVFSYIEGWDFLVAHYYCFISLSTIGLGDFVATQHDYENRALIWLYKICTTLYLIAGLGVMAIVFHGVRTKKRKPTQYTFRQKFVNILRKRRKPWLEIMDDQADAIAESFPVEGGVISSAVAAAAVAVTVNTPNSSEPTPPQNDLDSCGLSSDNNDSDNDFDDEDSLDDQCRSQHFPQIHKENNTDDIHHKMRQSGDFLDPASEENSPFTFRSIIANSHTSISADVDSDENEEGPQRRKAFNDIDNPKHSRKSSLPQRLDFRNFGAHRRSNDSTPELNRTQSQSQTQKNHHSDGKTEGGALASNLAKKKLWSPSSSYAGEDSGIHAASSQSTVEMESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YC88</accession>
    <name>A0A8B7YC88_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog subfamily B member 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Testis and spermatogenesis cell-related protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Testis spermatocyte apoptosis-related gene 6 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Testis spermatogenesis apoptosis-related gene 3 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Testis spermatogenesis apoptosis-related gene 6 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110978935</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB. Interacts with SUN5. Interacts with IQUB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022089980.1">
        <property type="nucleotide sequence ID" value="XM_022234288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YC88"/>
    <dbReference type="GeneID" id="110978935"/>
    <dbReference type="KEGG" id="aplc:110978935"/>
    <dbReference type="CTD" id="374407"/>
    <dbReference type="OMA" id="DIQFPEQ"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000033">
        <property type="entry name" value="dnaJ homolog subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF519">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="14">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022089980.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="39028" checksum="4B3B0D217801C133" modified="2022-01-19" version="1">MGKIERSWRKSVLEQLFAKTKSFVPTLSSKMGQDYYGILGLTRSVIDADIKKAYRKLSLKYHPDKNQETGAPEKFKQVSEAYDVLCDPRKKAVYDQFGEEGLKNGVPEGKMESGAWTHGYTFHGDAHKVFREFFGGDNPFSEFFDDIDGDLSMGFGGLRGRGRKKQDASIERDLTLSLEEIFHGCTKKMKISRRVMNEDGHTSSIRDKILTITVKRGWREGTRITFPKEGDQGPNNVPADIVFIVRDKPHPRFKRDSNDLIFTARVLLGKALTGCSVEVPTLDGRLLNVPINDIIRPGYEKVVPGEGMPLSRAPEEKGNLIIRFDIEFPKQLTSEKKRLLKEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCH1</accession>
    <name>A0A8B7YCH1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110978978 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110978978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090075.1">
        <property type="nucleotide sequence ID" value="XM_022234383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCH1"/>
    <dbReference type="GeneID" id="110978978"/>
    <dbReference type="KEGG" id="aplc:110978978"/>
    <dbReference type="OrthoDB" id="1517790at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849:SF4">
        <property type="entry name" value="GENE 29133-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18849">
        <property type="entry name" value="LEUCINE RICH REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090075.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="35319" checksum="E69B8C0817E1C0A7" modified="2022-01-19" version="1">MVTSSGGQGSRHAWVWRDFHSFPQRTWPRSLVAAMSEEMEIEGSSSLQSSSDANAYVAVTGTNIPIVTISTHTEKDQKPAKLPKLPSSRYRYTVWHELHNNEIKGDELNNPRVRRGPEVKDKIFYSIKDQQGRQLHHGKKGQEKKDYEKRIENWENSLMVNLSYQELGHRYQVENFMRILRRLIRAEKIQLVNDDLEDLSKVSFPSCTVLNLNNNYFASFTKLPKTPNLRTLLLCDNSIKSLDGLQNLRKSRLEVLDLRRNPISFQECYRQSVFKVLPDLRELDGIPRLISDIEGGFNLQNGCTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCR3</accession>
    <name>A0A8B7YCR3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Prolactin regulatory element-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110978628</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022089456.1">
        <property type="nucleotide sequence ID" value="XM_022233764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCR3"/>
    <dbReference type="GeneID" id="110978628"/>
    <dbReference type="KEGG" id="aplc:110978628"/>
    <dbReference type="CTD" id="10113"/>
    <dbReference type="OMA" id="YYVQPRI"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="221"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="106"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022089456.1"/>
        </source>
    </evidence>
    <sequence length="446" mass="49374" checksum="6F6395D348B06606" modified="2022-01-19" version="1">MATHLADLDFPPYVIKCVDETHFLVAGGGGHARTGVPNFIEIFELQRRGRRLFADSKLQYDTDVGEDRAAIMNAALRFDGKEYLLAAGKDEKCQFYKFVKTKEAMKEGEEEPKPNQTSNNGNDTGSTRKRKKAKEAKQTADSNKSKESTTKSEKTSSQEPAVVVTKFDLERLGSVQTDFTDGDKYQKAVCFSPNGMFFATGGADGHVRMWSYPSFEKQYEIKAHSKEVDDIIINPLGNRLVSVSRDSTAIVWKTVDGSKMCDLKWDGVKAEQTTSYRVRCCRFGFIDSDPSKSNMYTIHIPRIQGKTKSSYLTRWNAIKYTPEKTVCTGTDVLSALNISHSGNLVGLGTMSGSIGVYISFSLQKLRVVKDVHGIFVTGLCFVPMTRTTRDLLGDLETAVLSVSADKKVSIVALEPPMEFPAWLMFVGAFLLIILIFTGLAALGLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDF5</accession>
    <name>A0A8B7YDF5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Saccharopine dehydrogenase-like oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110979619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091289.1">
        <property type="nucleotide sequence ID" value="XM_022235597.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091290.1">
        <property type="nucleotide sequence ID" value="XM_022235598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDF5"/>
    <dbReference type="GeneID" id="110979619"/>
    <dbReference type="KEGG" id="aplc:110979619"/>
    <dbReference type="OMA" id="MQLRYHD"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022091289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022091290.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="47803" checksum="320557B7030462F4" modified="2022-01-19" version="1">MAEAGEAEDRPFSIIIFGASGFTGQYVVEELARVAEEEGMAGSLTWAVAGRSKEKLEMVLKQAAEATGKDLSDVGVILANVNDNQSMDAMCKQGKLLLNCVGPYRFYGEQVVRACIENGCHHVDISGEPQFLEGIQLNYNEKAKENNVIVIGACGFDSIPADMSVVFTKKKFPGVLNIVESFMAIQTGPKGGKGHFTTYQSAIYGFAHSDELPKLRQKFNYKPLPKYTPRLKKRGAIFYNEKTKKWCTLFPGSDVSVVRRSQRFLYENNDERPVQYGAYFEIGGFFSLMVLLFFGIIFAFLAKFSFGRKLLEKYPKLFTGGGFSHEGPTREQMDGTTFSFVLNAEGFSAGADNDQTKHDVTMVTKVTGPEPGYVATPIMMVQAGLVILSEKDNLPASGGVFSPAAAFSRTRLIERLDKRGIKFSVVETALPSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE10</accession>
    <name>A0A8B7YE10_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein eva-1 homolog C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110978868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer; disulfide-linked.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089876.1">
        <property type="nucleotide sequence ID" value="XM_022234184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE10"/>
    <dbReference type="GeneID" id="110978868"/>
    <dbReference type="KEGG" id="aplc:110978868"/>
    <dbReference type="OMA" id="SHSMNNY"/>
    <dbReference type="OrthoDB" id="5970528at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22828">
        <property type="entry name" value="Gal_Rha_Lectin_EVA1_EVA1C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22829">
        <property type="entry name" value="Gal_Rha_Lectin_EVA1_EVA1C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.740:FF:000001">
        <property type="entry name" value="Adhesion G protein-coupled receptor L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.740:FF:000003">
        <property type="entry name" value="Protein eva-1 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46780">
        <property type="entry name" value="PROTEIN EVA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="6">
        <location>
            <begin position="44"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="6">
        <location>
            <begin position="154"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022089876.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="52113" checksum="AC58BFABEA2D412A" modified="2022-01-19" version="1">MMAELLPVVFTVIVGLTFPYLPISRADENSDLLMSTLRSKFVFACDKDFLALKCPNSTVITIDNANYGRQVSSERMCPYRWSTVGSYHVTQYHENTNCKAVNSLQVIENMCESRQFCKLKVSSDLFGGDPCPGTNKYLDVTYKCKPSIFQNMVVCENSHMMLHCNAKEVLAIHSAGFGRPIAANMKCPSFSMDEIECSSSSSLEEVMKRCHGKRHCTVKASTRIFGDPCQRDTYKYLSVIYTCVSKRIFRKPRRYTGSVTVPQNFAVSLTNPTLSPEYGLDQTTFTMTESTDQSQGLLGTAPANNHSVTISSVNISLSQQPSATDDQDKATGFFTSIIAAIGSIHLNTEVFVLYMLVGCCIGTIMTLLWCVVRLKCKNCHLKKKIQESGGASSTTEGNRTLPRNGSVLESVRQENRVDINEIWNTPPPSASTMRPENGISANRRWEPANTPPRETQTLPAARNLNSYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEK0</accession>
    <name>A0A8B7YEK0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110979483</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110979483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091007.1">
        <property type="nucleotide sequence ID" value="XM_022235315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEK0"/>
    <dbReference type="GeneID" id="110979483"/>
    <dbReference type="KEGG" id="aplc:110979483"/>
    <dbReference type="OMA" id="RILIWCT"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022091007.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32989" checksum="F8A620A4FEE137D1" modified="2022-01-19" version="1">MHGTFKEKVDRQDLTMAGEHTEQVRILIWCTARSLSTVLARSLSQYPASQCLLELFGAAANFGPDRRFPETELLQPRLSFKFVKELYEQPWAGKSLVLGKELSYVMIGKQDMIPEGYQHVFLIRNPQKSVKSLEDRMSKVAYKKKKEFYLGLNQFKNLSEMHQHVTKTLGKKALVLDADDLKSNPSEMLQCLCTAVGLQFTDKLLEWDKVSGVPGNWMVNEKQWEDHERVGWFDRLLESTGFNPLETDPRVCPSEGQPSPHFKQMIAEALPYYQELYQLRIKPQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YES0</accession>
    <name>A0A8B7YES0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110979426</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090895.1">
        <property type="nucleotide sequence ID" value="XM_022235203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YES0"/>
    <dbReference type="GeneID" id="110979426"/>
    <dbReference type="KEGG" id="aplc:110979426"/>
    <dbReference type="OMA" id="DESAEMY"/>
    <dbReference type="OrthoDB" id="2156856at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000032">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34988:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34988">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="2">
        <location>
            <begin position="342"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090895.1"/>
        </source>
    </evidence>
    <sequence length="479" mass="53599" checksum="D809D77761BE98FE" modified="2022-01-19" version="1">MATQDVKANVKPHEDSGRGEIWTVEDTRHLISIWGDPSIQRKLRSIFRNNTVYDEICQRLREHGVYRTPAQCRNKTKNLRKGFRELKLGNGRCSRSVSRQSSLFFEELERVWGQDYQNNPGEFGGHEGEIFPTENKDGEDNGTLNDGCSIDGATLSDVEPREYDSGDTTQSHGPERVLAPHIYSPELHRTYTDRKRAESGATSLAALQQLNQENMERMKDTVLELNRSFLEQMSAAEERRERLSKEHEVRLFEMFLQNSSGRSSQSSKVYPVRLAHSDMQHHSNHDQPSQGSDQSVNRTMPDCHAANRPVGIEEGQYAKAERLSSQGQSTPGQPLRTPKVNSSSLRCLALRLHPGDEIKESLRRLAEEKGIQAACILSCVGSVRCAELRLADSTTVVKLNTNHEIVSLVGTVSTAGMHLHASLADEEGKVVGGHVIGNMEVFTTAEILIGQLPQVVFKREMDKETGYHELVVEGNTDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEU4</accession>
    <name>A0A8B7YEU4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110979537</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091107.1">
        <property type="nucleotide sequence ID" value="XM_022235415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEU4"/>
    <dbReference type="GeneID" id="110979537"/>
    <dbReference type="KEGG" id="aplc:110979537"/>
    <dbReference type="OMA" id="MTSIWSN"/>
    <dbReference type="OrthoDB" id="6161953at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042506">
        <property type="entry name" value="IQCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16049">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16049:SF8">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091107.1"/>
        </source>
    </evidence>
    <sequence length="567" mass="62529" checksum="185ED57253F565A0" modified="2022-01-19" version="1">MDKLTNLLSENVDDSSWDEELICRLQAYIRAFLTRKQFQEVRSLYKEIVREVEGDILLGNQTNVSWRTHLPCRPRCSPKLRKCFAVVKDGTKTTQTCLTPSGQRPVEGADQDVKSQGTDLDSRSHQEEIPFEADGKELSGLGGECQDPVHQVHAETLPSCEGEGLPELDKVLVNQGQSLTPSEEGNESVDFHDSTRRLESVSERSSKHSKQGSPSTSVDYTLDFESCSSSATSEAARLISTSTQLKLQQDSGNAASLELCVVALAGDKTAVTEGNLPNGNQVSEVTSDKMDEKQMEKRENDWNSAEDFTPVQSSGTNTISQPNLQRLDRKSPDDCIHVDGMVSSTRDEVRTFSPEGDEEAMSVSQEEASKSGGSSDAKDSLKVAPSKMQDLTEESRGDLNVHVASNTLTDCQDQVNRNSNQDQANGKSKMESVPTPPHPPNVSDEGKAAAESTMHGSRDEEEEGGGLGPATREMQEARETTRLASEKRSYEQDFSIAADMTSIWSNENSFTEMPDSDYPIDLRELQRLRNSVALELLWVQQAIASRKNYLRLKSNMEPPGQQRAENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YF23</accession>
    <name>A0A8B7YF23_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110979947</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091843.1">
        <property type="nucleotide sequence ID" value="XM_022236151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YF23"/>
    <dbReference type="GeneID" id="110979947"/>
    <dbReference type="KEGG" id="aplc:110979947"/>
    <dbReference type="OMA" id="WRLEAYI"/>
    <dbReference type="OrthoDB" id="10071553at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="976"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1195"/>
            <end position="1209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091843.1"/>
        </source>
    </evidence>
    <sequence length="1234" mass="138180" checksum="ACB51A216A728CC5" modified="2022-01-19" version="1">MSHQEEESKGVHQPHMIPVQHDEVEESLDRVEEIHDEVKQAQKDEFQNSRGGISDTNDGQACDVELSLEVESANWVPNEISAEVNHFLRHGSGEMGALEVPPEVQGEAIKDEAKEKRKIEYDQNLKDGEDEDESCSEENTDDDDDNLVTSEEDELDSMVGYVINSAGSSLTNNFDVFTFKSFHINENITSRKEGPEEDSIILDGDAAPDAEEVLLIHSGDENLRGETLNVSDVYAGDDVIEASDMFRQGTCFVAADSSSVKHEDTEGVNDKICASFKNVDNVTLRVEEANERKKTDDDSLHDKCSTEKPQDDSFSRSVENRKPLEIKVTDNAADLIGLEGTHESLEQGSPTWSKKQEDAMCVKKQENDGGPSLTHTAEVLEANLQLPPIDTVCRTSKVQSQEVTETLLQKLENDLPKCNKEEKTSSVTDMTSSVNGPKVTLTVSNIASDSDDDDDLYDTERKPSVNINTAENDWECLAIQQISKSQPHVWYPTYNTTHHIVEDASKTQHNNTGKHLDADTLKMNIPSKVPSNEKVTSTHDVSESTVTAKSLSSHNLTTGQSMPSVSSQAPASQPDLPETESGMAVINDRLRKKIVLLERRLKELALELTFLGDRNWRLEAYIDCLIKTLEVLEVTDVVDLDQKKLPLSLFKVKVKAGYKLGSYNGIPSRALQSYKKEGRQPPYVDLSGWGDTDKPTQRPDLIDPTPLPSCDDDVGLSVSQMYHYESQLEEISIQNQILEGQLQEANELVQSMMGESSADERQTGPQDLHQAKQQKEQGIQTRPHDTSTLPQNVGVLQQQVQDLRDEYHQGGQEYWQQPQQEQQQQLFLTGVMPQIQTQPECYAMHEGEQYSLPQQQLQHYQLQHCQPVVQPQQQQLQQPQQQAWNPQAVQEETVLPNCCDWESNEKLSLHDPLEWPTLTESQAQVTGRSQTGTGTEAGPRPLQLQTQPFATTGPASHVSESSPTVLSNPVKDKSTLHSSLEQPASSGSIPNHENRCKASCYHDNNPKEASSSGTVSSQSFYRGRRFESDSRGQPRYNHRSLEQSLSGIDTLPRGHRLEESMRFEHWDPHVDRLSSLIPGEFPVDLHGEAWRKERSPYHDVRNAPSRHPLPFQRNLDRSRRFFHCDSVLDSYCPDFSNFQHAPTFKEDLGETISASNSQFMLSNGYAFDKFPSPPSTRGFSSLGSSTSTGALPYPRQHKRQSTPTRRGKPWTRAGSCTSPLRSRHNPEVTLSDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFU3</accession>
    <name>A0A8B7YFU3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110980085</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092109.1">
        <property type="nucleotide sequence ID" value="XM_022236417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFU3"/>
    <dbReference type="GeneID" id="110980085"/>
    <dbReference type="KEGG" id="aplc:110980085"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092109.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32277" checksum="9B4A4B362B22E01A" modified="2022-01-19" version="1">MSLDLWASFSREAEEKAPKRLEDEAASHSVSTGNFKRGRRSRQENISSQESVSQAGVGPHGSDHDYVGSVLEFADLEINPDTFFEVVKDAACSLPIRNAHFGPREDPKITSARFDTRQSKVFLSLAAGQKKLVDKLWSRNPERFSLYHASTLAHYKITEEHYRKYMMPSQLDPLLAHELGRVVPGFDIHAPKLPDKSLNMADRRFMSIEEAHDGMACAVSQLEELLQNTLDHQSLNVLKGLVDIGSASRSLSAAQETTLDMLDLQVREATNAKLARNYLYMWLQQTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHZ4</accession>
    <name>A0A8B7YHZ4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110979593</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Forms a heterodimer with smc6. Component of the SMC5-SMC6 complex which consists at least of smc5, smc6, nsmce2, nsmce1 and nsmce4a.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091241.1">
        <property type="nucleotide sequence ID" value="XM_022235549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHZ4"/>
    <dbReference type="GeneID" id="110979593"/>
    <dbReference type="KEGG" id="aplc:110979593"/>
    <dbReference type="CTD" id="23137"/>
    <dbReference type="OMA" id="RFWTSQP"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000793">
        <property type="entry name" value="Structural maintenance of chromosomes protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="12">
        <location>
            <begin position="50"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="279"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="650"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="716"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="779"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022091241.1"/>
        </source>
    </evidence>
    <sequence length="1078" mass="125405" checksum="566F8ACC6855C1CC" modified="2022-01-19" version="1">MASKSRKREADLHQIPGRNVNRNDVVMVNGVSGKSSRKPGTSKSFVEGSVVRILMENFVTYDKCEFRPGPHLNVIMGPNGTGKSTVVCAMCLGLAGSTSLLGRAKEVGEFVKHGSNEAIIELELYKDPKNVIIRRVITKQGNRTTWFLNGSRCHMRDVQDKVKSLNIQISNLCQFLPQDKVVEFANMSNVELLENTEKAVGSPELFDQHCRLKNFRNEQKEMLLQHQEMSHHLEKLTEKNSRLEADVKRYQERQHHLEVIETLEKKKAWVEYDTKRKMYVDLKKRQEALKTELREAQAVNAPIQQKLDTLTAKLQELDTVSKEMTNEARQLANAANKKHEKIDEFSSDLTEIQDELRVKQQDEEKRQAKIRGHLSLVEGWQKELEQIPPVEDIKPQLDQNAASLRAIVREVSGIDTEYNGIKTERESLQREKRDLELRLRRLNDQKDMRLGELQKYYRDTYNAVEWLRSNQDMFKHKIHEPVALVINVPNKEHAKYIEHAIPTNDMLAFVCEDADDMELFVSLVREKQNLRINVVKSPGDPLSSFKPQKSIDDVKRWGFNHYLRDLIEAPEAVMVYLCKMHKLHNVPLGSRVTQDSIDKVVKESGVTRFYTPDHNYIVRRSRYGNHQQSTDSNFVADARLLNISVDMSAKRELEQNIQEIEHQLGVGQQRYKELQQRRQVLMTQDNELKEQKKGLIQKRDRHKTILQNIAAKREAIRKCEASAIDVEAEMAKASKKIKAINEKKLKLVKEFSQLIKDCIERTKEKVELGMKYAVIFNQKTHIEATQREASANLQRLENEKIELLTILRNTKDVARQLIRRAQELTGSEEPSTELREAFSTCPDDLDEIEQKIHYVQAQADCLFETDQRVVQEFEHRKVEIQSLTEKVERSQQQMDRKLSEIDDMKQHWKEDLNGLIADINQQFSNFFEAMGCAGEVKLQYDSEEDYDKYGISIQVKFRKSEQMRELTSHYQSGGERSVSTILYLMALQELNKCPFRVVDEINQGMDPNNERRVFELVVKTACRENTSQYFLITPKLLLNLSYGPKMTVICVYNGHWIMPYSHWNLEAFCRRRRRLLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIU1</accession>
    <name>A0A8B7YIU1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sorting nexin-14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110980283</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092527.1">
        <property type="nucleotide sequence ID" value="XM_022236835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIU1"/>
    <dbReference type="GeneID" id="110980283"/>
    <dbReference type="KEGG" id="aplc:110980283"/>
    <dbReference type="CTD" id="57231"/>
    <dbReference type="OMA" id="MYVYVIS"/>
    <dbReference type="OrthoDB" id="5957963at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06877">
        <property type="entry name" value="PX_SNX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08722">
        <property type="entry name" value="RGS_SNX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037436">
        <property type="entry name" value="SNX14_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037892">
        <property type="entry name" value="SNX14_RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF44">
        <property type="entry name" value="SORTING NEXIN-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="121"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="329"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="547"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022092527.1"/>
        </source>
    </evidence>
    <sequence length="920" mass="105611" checksum="4994E3A693721C64" modified="2022-01-19" version="1">MATWQVICDEVAGLREQMARNRHFTAAVGCLTLLTVVFYNHMSILAIPWFFLGGMASFYILFSHVSVLPNLLIMFERQQPHPTSQHPSALICTVCGDADCVRHKPDLTLTKVQPWNDIYIPERVDIALSELFELILKDYIYSWYTPLISKEEEFVNELRVTLRHIVAVVLRRVREVDLPTFILDKLVKAALSHLDVLLRAKRKAKWGEEFQDLVIKTYGNHLHCAVRNRKAELEYLRHLCELLFPVLIPANSHDNKSTQTFVREVVSGSVFLLGMDVVADPDIVNKLLMIFFDEEPFPPAIDPPSEKVILLESFCNVHPVEKSSALQYEMSEILGNHSLLFPFLQYMKRDGALNILQFCLTVEDFNRRSLVPDMTDEQKQSLHREAQDLYQLYFAPGAVDRIKFDVDIEDEMKEIVNGPYEGVTRLRTSSTLFRAYEHAYKLMENVFCPLFHHSDEYFTLMCGKRQQVLPKKPVRVVVKRSSDPIAAMHRLGSKIKGVFRSSNADSDTASMSSLDIAESESSQPTSDAELASDEEEAGMKSPIHDMSAWRVSIPRVEARLEGTKDYFVYIIAVQRIDVKEGGGEETSWEVERRYHEFHVLETKLREFHGIFDDAQLPQKRPLPFASRSLDFMEKRKDSCEKFLQTLLTKPNLRGSQLLYSFLTKSEEFVNKFLGDVNIGKLVRTMSYRVIKERGQHLDPFLQSFIASVEAPKPKAGKLEEPVDPAKHLAEKLDSPVFGDNAGLPLVRETLKEPNPDPSANYLQLNGIFDYILYLATAVFDVAPWMHQGLIVFQKLFKNSLETFLDSYLAKKLEIVQSEEQVEDIIHNLRDVLFFDDEPPRTDAQKQQRKEEAFQRMLNFFPKQLHQVIGEDKFSAGLRFVFDGLQYPKLNKQLAYTLLDIVILEAFPELSESVKEIPGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJ63</accession>
    <name>A0A8B7YJ63_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRKCA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein interacting with C kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Protein kinase C-alpha-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC110980249</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Monomer and homodimer. Interacts with CXADR. Interacts presynaptically with the glutamate receptors GRIA2, GRIA3, GRIK3, isoform 3 of GRIA4, isoform A of GRM4, GRM7 and GRM8; with NAPA and NAPB; and with BTG2. The interaction with NAPA and NAPB disrupts the interaction with GRIA2, conducting to the internalization of GRIA2. Interacts with PRKCA; with the amine transporters SLC6A2 and SLC6A3; with the channels ASIC1 and ASIC2; with the GTP-binding proteins ARF1 and ARF3; with the ephrin receptor tyrosine kinases EPHA7, EPHB1 and EPHB2; with ERBB2 and through its PDZ domain with the C-terminal tail of PRLHR. Interacts with UNC5A. Interacts (via AH domain) with NCS1/FREQ; in a calcium-dependent manner. Interacts with F-actin and associates with the ARP2/3 complex. Interacts (via PDZ domain) with ARF1 (activated); the interaction blocks Arp2/3 complex inhibition. Interacts with SORCS3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Synapse</location>
            <location evidence="21">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022092445.1">
        <property type="nucleotide sequence ID" value="XM_022236753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJ63"/>
    <dbReference type="GeneID" id="110980249"/>
    <dbReference type="KEGG" id="aplc:110980249"/>
    <dbReference type="CTD" id="9463"/>
    <dbReference type="OrthoDB" id="5917245at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098842">
        <property type="term" value="C:postsynaptic early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097062">
        <property type="term" value="P:dendritic spine maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002092">
        <property type="term" value="P:positive regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07659">
        <property type="entry name" value="BAR_PICK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06722">
        <property type="entry name" value="PDZ_PICK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000023">
        <property type="entry name" value="Interacting with PRKCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000073">
        <property type="entry name" value="Interacting with PRKCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037959">
        <property type="entry name" value="PICK1_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF1">
        <property type="entry name" value="PRKCA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="8" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ" evidence="25">
        <location>
            <begin position="34"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="AH" evidence="26">
        <location>
            <begin position="156"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00093501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022092445.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="46962" checksum="6D94C4D90F885EEB" modified="2022-01-19" version="1">MEFTGETFLFSLLYHGQLDIDPCDQRGMEAIPGNVSLIKDKQNLIGISIGGGAPLCPCLYIVQVFDNTPASRDGTLASGDEIVGVSGKSVKGRTKVEVARMIQSIKSEVIINYNKLHADPKQGKSLDIVLKKVKHRMVENMSSSTADALGLSRAILCNDVLIKKLDELQATAIMYKGLMEHAKKMLKAFYDLSLSHRAFGEAFGVIGAREPQPKASEAFTVFADAHRNMEKFGIRLLRTVKPMLTDLGTFLTKAIPDTRLTIKKYADAKFEYLSYCLKVKEMDDEEYAYATLGEPLYRVETGNYEYRLILRCRQLARAKFAKLRSDVMVKLELLDQKHVQDIVFQLQRLVSAMANYLQDCHQQMKDAEIFPIEVDLLRTTINYDTSNQFNDEDEDEEETGEGEDAVIEAEEELISPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJK0</accession>
    <name>A0A8B7YJK0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110980782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022093429.1">
        <property type="nucleotide sequence ID" value="XM_022237737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJK0"/>
    <dbReference type="GeneID" id="110980782"/>
    <dbReference type="KEGG" id="aplc:110980782"/>
    <dbReference type="OMA" id="NIYLCAY"/>
    <dbReference type="OrthoDB" id="6286464at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="24"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022093429.1"/>
        </source>
    </evidence>
    <sequence length="495" mass="53283" checksum="568AFB1B2264FBD1" modified="2022-01-19" version="1">MEITRRTSVRFGPPTQGSIWAIVIIIAAHLNLALVECSLRTTEVFYLRWREEFETSAKQTAAVQSIAWSLSCSCGLIGGLMVKRFGCRMTGIVGGLLAVLGVFGSAWVRSIYQLYITAALNGVGLGILVNVSVVAVAQNIKQRYRTANALMYSGRGTGKMAAPPLVQFLLTSYGWRGAILVIAAITANAVVFASLFRPSRTLRKTELGNTSQNELDREKRESSSVQEVHPGQENDAEADRETETHVGTRDVEMIDAEMHRSDQNIYLCAYTPIPTTNDELRLKVPLGSRIASALGLVIFRKSYRFGLLCFLGIVCIIPFSGSAPFIIPRAQSIDITPSVAALLLTLNGIGSLLGRLGNGLVISWKLSAETVCSISAAVTGTSLFLMNADSFVCMSVVSFLLGLSSGVMYSVCIVLTRQYVGDLQFSVCFGIYSTCVGIGALLGGVAAGWVFDVTASYKAVFYVLGGIAFACAFLMCLLPVLKRIEPGIDVKSTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJU8</accession>
    <name>A0A8B7YJU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Thioredoxin, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110980381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092695.1">
        <property type="nucleotide sequence ID" value="XM_022237003.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092696.1">
        <property type="nucleotide sequence ID" value="XM_022237004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJU8"/>
    <dbReference type="GeneID" id="110980381"/>
    <dbReference type="KEGG" id="aplc:110980381"/>
    <dbReference type="OMA" id="VLVIMQN"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000001">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF3">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022092695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022092696.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17751" checksum="EAE1C3F1E023E85F" modified="2022-01-19" version="1">MAFRLRVLTSALLSARQCQLRLVTPSAMTGIMNNAVAGQRRHLSSADSPPYEEFTVQSTEDFNQKVINSKMPTVVDFYATWCKPCKALTPRLHEVLSERPGRVQLAKVDVDQHTDLAMDYDVSSIPKVVMFKEGKVAGEFVGLMEKDKIESFIDRLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK49</accession>
    <name>A0A8B7YK49_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="9">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110980888</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine</text>
            <dbReference type="Rhea" id="RHEA:20517"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="5.1.3.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 9">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022093638.1">
        <property type="nucleotide sequence ID" value="XM_022237946.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093646.1">
        <property type="nucleotide sequence ID" value="XM_022237954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK49"/>
    <dbReference type="GeneID" id="110980888"/>
    <dbReference type="KEGG" id="aplc:110980888"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003974">
        <property type="term" value="F:UDP-N-acetylglucosamine 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007956">
        <property type="entry name" value="PRK10675.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="10">
        <location>
            <begin position="9"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022093646.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38754" checksum="C7B6B18E13BD372E" modified="2022-01-19" version="1">MADGTSYVLVTGGAGYIGSHTVLELLKEGYSIIVLDNLSNAAKGVNSIPESLSRVRNIVGGEIKLVFYEVDMLNVEELRNIFKKHKIQSVIHLAAKKAVGESVEKPLLYYSVNVTGTLNLLNVMKEFKVRNMAFSSSATVYGTPRKLPIDELEPTGNITNPYGRSKFIVEMILKDLYQSTEDWNIILLRYFNPIGAHESGQIGEDPSGPPNNLMPYATQVAVGKREELKVFGNDYDTPDGTGVRDYIHVVDLAIGHVAAIKKLEENCGLKVYNLGTGTGYSVFDIIKGLEKAAGRKINYSIVGRREGDVASVYADSSLAEKELGWKAVRGLDKMCEDHWRWQSQNPNGYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKJ0</accession>
    <name>A0A8B7YKJ0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110980607</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022093142.1">
        <property type="nucleotide sequence ID" value="XM_022237450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKJ0"/>
    <dbReference type="GeneID" id="110980607"/>
    <dbReference type="KEGG" id="aplc:110980607"/>
    <dbReference type="OMA" id="MIDSWNS"/>
    <dbReference type="OrthoDB" id="17569at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF78">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="14">
        <location>
            <begin position="465"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="765"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022093142.1"/>
        </source>
    </evidence>
    <sequence length="806" mass="90013" checksum="9ECFE7A10EC1C446" modified="2022-01-19" version="1">MKMDALHQQLLFTTSLIFLSLTTETLCLTNITLGGLFSFGGAGTDWDGSAILQSTLLALQHVNEDPSVLPGYYLKLDVKNSKCRPGEGMKGFVDLINEEPTKLMLLGASCSVVSQPVAETAQHWNLVQMSASSTSDVLSYKERFPYFFRTNPAQSGLNTPRIAIMKEYGWERVAIIHESNDVYTNAMNKFSEELSLNNLSLVAKESFASGETPSAQLRNLKDKDARIIVSSAYTEGYKLMFCEAFRLEMYGPRYVWMIDSWNSLYWWKNVTHLGCSEQEMYQVVQHHVGTVFLNMRTDTERTASQLTASQYQDAYASYTNGHPYPGEDLAPFGYDSVWALALALHRVASDLAAENSSIRIEDFDYDNTHSLRERLVMALSNLEFEGITGFVTFDASGDRLAPFKIEQLLDGSEETVGLYLPEEGIQWTREQQLTFIEGIAPMDGPMRETLYIGIDAVTFVAFTVLAVIGMGGTVAFLIVNLIYRAERVIKMSCPNVNNVIAVGCFMCYVDVIVAGLNQNVVSQWVSNAACLAQVWILPISFSLAFGGLFAKTWRVHVIFRNKTKRTRIVDYHLFVIIGVVVAIDVVIISVWTGHDPSRLVRTSLPEQVDTAADKITIRMVDKCDSPESPRFLWIGIIFCWKGILLMFGAFLAWETRKVTIPQLNDSKYIAVAIYNVAVPSIIVAPLVTFISTDLPGVSYILTASCILFGTTVTNSLIFIPKIVALRQGKSNSNSQDQHPFSVHNQVGPALERLATCSSSVDDSTIREKEKEIKDLKNKLKRKDEEIERIKEVLDRTDHGQGTRPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKM4</accession>
    <name>A0A8B7YKM4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Lysophosphatidic acid receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110981005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093819.1">
        <property type="nucleotide sequence ID" value="XM_022238127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKM4"/>
    <dbReference type="GeneID" id="110981005"/>
    <dbReference type="KEGG" id="aplc:110981005"/>
    <dbReference type="OMA" id="LVCWIPA"/>
    <dbReference type="OrthoDB" id="5965119at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246:SF27">
        <property type="entry name" value="ADENOSINE RECEPTOR, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24246">
        <property type="entry name" value="OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="23"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022093819.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34380" checksum="092174F52A3AD84E" modified="2022-01-19" version="1">MTVDYLRVIFTLVFTFSVLAVAANLLVILVFAGTRHLRIKYYAFVFNLALADLGFASVASVYPWYNKNSTVEDLLQICSIVNALTVLAVAINRYLALSLMPPSRYDALVKSVRLFIVCVLMWCFAIGVTVPQMLGSTINSFDVFHAVVRSIGEIIVWSITTVVYVLVFFKIKRYAPPLAESPAIDTDVEQNDTRYRQTRRMLVTFSIICAVSLVCWIPADVNILIVFYNQDILQVNWGFRVYYAVALLVYSLNALADPVIYWWRLPGFREAAYGLVCRCFRKDRSNDLNVRSGNEHTITDTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YL93</accession>
    <name>A0A8B7YL93_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022093210.1">
        <property type="nucleotide sequence ID" value="XM_022237518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YL93"/>
    <dbReference type="GeneID" id="110980642"/>
    <dbReference type="KEGG" id="aplc:110980642"/>
    <dbReference type="OMA" id="HKRYGWL"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000036">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2Q-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="177"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022093210.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37501" checksum="87570DA57FEA2230" modified="2022-01-19" version="1">MAAGLSKLLRQSNRAPPSARRKRHSFSRVRKLRIGNQESTNSPENSVTGPISSGVGGGGGMGGGGDSGEGGGGEAGVGSGARSRVVAHKEPDIRREINTVRFSDDSYSPSEHHGVTLPGMIPADTPAPPASVKAKSAPILKQQAGASTSKFKPAGQDISSSALEDIPQPTKKYVSNVRTRRVMKEFEATNRISQSEDPMFEVSLVSDNLYEWCIKLLKVDPLSQLHSDMKATNTTSIEFNMTFPDNFPFAPPFVRVTAPRIENGYVLDGGAICMELLTPQGWSSSYTTEAVILQLGATLVAGHARISQSKKKLFGEIPFNKQEALESFNNIVETHKRYGWLDPPGEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLA2</accession>
    <name>A0A8B7YLA2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cystic fibrosis transmembrane conductance regulator</fullName>
            <ecNumber evidence="7">5.6.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">ATP-binding cassette sub-family C member 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Channel conductance-controlling ATPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">cAMP-dependent chloride channel</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">LOC110980767</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>ATP + H2O + closed Cl(-) channel = ADP + phosphate + open Cl(-) channel.</text>
            <dbReference type="EC" id="5.6.1.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>hydrogencarbonate(in) = hydrogencarbonate(out)</text>
            <dbReference type="Rhea" id="RHEA:28695"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.6" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022093417.1">
        <property type="nucleotide sequence ID" value="XM_022237725.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980767"/>
    <dbReference type="KEGG" id="aplc:110980767"/>
    <dbReference type="OMA" id="RFTADFH"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005260">
        <property type="term" value="F:intracellularly ATP-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18593">
        <property type="entry name" value="ABC_6TM_MRP4_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000026">
        <property type="entry name" value="Multidrug resistance-associated protein lethal(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000014">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000482">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030240">
        <property type="entry name" value="ABCC4_TMD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009147">
        <property type="entry name" value="CFTR/ABCC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01851">
        <property type="entry name" value="CYSFIBREGLTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0868">Chloride</keyword>
    <keyword evidence="19" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="23" id="KW-0407">Ion channel</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="22" id="KW-0413">Isomerase</keyword>
    <keyword evidence="18 32" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 32" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 32" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="823"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="884"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="32">
        <location>
            <begin position="968"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="34">
        <location>
            <begin position="141"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="33">
        <location>
            <begin position="534"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="34">
        <location>
            <begin position="828"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="33">
        <location>
            <begin position="1162"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00029720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00031358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00033163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00034073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00044653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="RefSeq" id="XP_022093417.1"/>
        </source>
    </evidence>
    <sequence length="1427" mass="159119" checksum="4029328200C8E1DE" modified="2022-01-19" version="1">MRRWPNTQFLMAAQNRRPSSAGDSKGSHDDGVTEPCQAPPCQSGRQPHPLSRAGIFSKAFFIWMFGFFRRGYKRPLVEEDLYDVLPEDSADVLVTNLEREWNKELETSNVTGRPPSLCWALIRAFGVKFMLYGLPAFFKEVFLKMVQPVMLARLVLYFSTDLVSTTEAYLQAAGLSLSSLCLIVTHHCCFFGFGLTGMRLRTACSALVFRKALKLSNLALSETTIGQLVNILSNDVNRFDQAFVFAHYLWIAPFQLTVLFVLCWREIGVSCLAGLSVLILMAALQGYTGKLFSKLRSKTALLSDARLRIMNEVISGMRVIKIYAWEQSFGKLVAESRGKEIRKILYSSYLRALIFALLFDATILTAFATFVVYASLGNPVTSSKVYPVVSLFYGARLCLSLFFPFGVMNGAEGLVSIRRIQKFLLMEELARHTGEATVNINANFGLEKPVILLEEIATNGFVAPREANDDNLAEDVTAASRPLEKEVRTSSTNYLIQSKGDEEVGGYVGPSEMEEDDDLDKPKPSLETGDRKGILVENLYGSWNKDLSNTVLQDISFRVEPGELLAVVGPVGCGKSSLLMALLGELPTVSGVNALPGWVGYTAQQPWILSGSLRDNILFGSEYESAKYKRVIKQCALTRDIELLPHGDQTLVGERGVTLSGGQKARVSLARALYIDADVYLLDDPLSAVDPAVGRHLFEKCILHQMRDKARILVTHQLQFLDKADKILILKQGSASGYGTYQELQREGIDFAALLKKKSEDDDDTGDKVQVLERLRRERKISTCSSASFCPDQDEVETPVGIAPEEMAVGTVEWMVYIRFLRAAAGFLFLLVWVIIVVGAQASLTFTDLWLATWVYEEEQYLAATNQDNQNATTYDNQSYYVQIYAMLCGGSTLLLFVRSFLFFHLFVTASRALHNQMFASIIRAPMQFFDTNPVGRILNRFAKDIGFMDDVLPGTFTDFLQITVNTLAIITLISIFNPFCLAFTIPIAIVFFLTRRYYLASSRDVKRLEGVARSPVFSHLSATLTGLSTVRAFKVQRRFIADFDRYLDGHTRAWFLFLATSRWLGVQLDFFSTLFICGVSFTSVMAAGLLDLNSGIVGLSLTYAISLTGTFQWAVRQSAEVENQMTSVERVCQYIDIKPEAPLETDHKPPPDWPQEGGITLQDTSLRYTEDGPQVLRNISCSIKPKEKLGIVGRTGAGKSSLMTVLMRLAEPTGTIMIDGVNTTLIGLHDLRKKVSFIPQDPILFSGTLRKNLDPFDDHADCDIWKAIEEVELKPAVEELPDKLEAVLTEGGTNFSVGQRQLLCLARAILRQNKILIVDEATANVDVRTDRLIQATIRQRFKHCTVLTIAHRLNTIMDSDKVMVLDAGRLIEFDEPYTLLQEDSAFTRMVQETGKAEMAKLLQIAADKHAEKVAHDPEDTSDIPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN30</accession>
    <name>A0A8B7YN30_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110981418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022094673.1">
        <property type="nucleotide sequence ID" value="XM_022238981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN30"/>
    <dbReference type="GeneID" id="110981418"/>
    <dbReference type="KEGG" id="aplc:110981418"/>
    <dbReference type="OMA" id="CDVGVIP"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="9">
        <location>
            <begin position="70"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="10">
        <location>
            <begin position="302"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="600"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022094673.1"/>
        </source>
    </evidence>
    <sequence length="659" mass="72355" checksum="8FBD72F674884543" modified="2022-01-19" version="1">MEGQSSSVLQISTLAVGRGAGGRAGTAGSHGSGSDVGGPLRAPIRPKPLRVRSRKLSGKDSSFAEETESRVLVLYAGGTIGMYKENDVYVVRPGYFHKLVRAMPMLNDEEYASLLDPSPGMEERPFALPISQEGVRVIYDIHEYKVLKDSSNLNITDWVEMAEDISRYYRRYDGFVILHGTDTMAYTSSALSYMLENLGKPVILTGAQVPLPELRSDGRDNLQGAIYIAGHFVIPEVALYFNDKLYRGNRVVKVSSESFSCFDSPNFPPLVKMAVNIEVAWESLFRPNSLESFRVHSSMESHVGLLRLFPGITKEAVQAFLNPPMRGVVMQTFGAGNGPDDRKDLIEVVREATGRGMLIINCTQCARGTVSPFYRTGKSLLEAGVIPGGDITPEAALTKLCYILGKEELSQEEKLARLRCNLRGEIKLGGRHKDSMTLKDSEFIRAVVDTLNVTSSQEVKAVQDALFPPLMCAAAKNGDLASLKYYRECGGDLSLADYDGRTPLHLAAGTKNVKVVEYLLERGCSIYVKDSFGNSPFFDSIRTKNLEVIKLIKKTGGHLIHTSHQHELGTILCHAAALDDRDMLEAFFAAGEDMNAKDYCGNTPLHMAVLKNSKECIDFLLEAGADPSLKDHCNNTALRIAEEKGLEGVVHRLEKVTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPF6</accession>
    <name>A0A8B7YPF6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Charged multivesicular body protein 4b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110981348</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094552.1">
        <property type="nucleotide sequence ID" value="XM_022238860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPF6"/>
    <dbReference type="GeneID" id="110981348"/>
    <dbReference type="KEGG" id="aplc:110981348"/>
    <dbReference type="OMA" id="KIDHELM"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022094552.1"/>
        </source>
    </evidence>
    <sequence length="213" mass="23955" checksum="BF1B0A965C0AE0E4" modified="2022-01-19" version="1">MSFLFGKKKQPQKAPSTGDAIQKLRQTEELLEKKQAFLETKIKQELQVAKQNGTRNKRAAIMALKRKKRLEKQLDQIDGTLSTIEYQREALENANTSTEVINTMGFAAKALKAAQQNMGVEDVDDLMSDIQEQMEVANEITDAISNQMGFGQDVDEDELFKELEELEQEELDEQLLSVGPSVAPQLPDVPTERPAKVADQEDEDMRELAAWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQI8</accession>
    <name>A0A8B7YQI8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094725.1">
        <property type="nucleotide sequence ID" value="XM_022239033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQI8"/>
    <dbReference type="GeneID" id="110981449"/>
    <dbReference type="KEGG" id="aplc:110981449"/>
    <dbReference type="OMA" id="VHYERSH"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35760">
        <property type="entry name" value="SI:CH211-22I13.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35760:SF1">
        <property type="entry name" value="SI:CH211-22I13.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022094725.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24958" checksum="469FB0D5F4842FC8" modified="2022-01-19" version="1">MGGEKDAYNHENREQSRRRHSSSSPSSSCSQEMNSKDHRVKPRTVSPTRSRDLQRHSGKRDRGRSSSSNASSPHRGRDKHRKKLKRRYSSSSSSTSSSSSSSSSSPSRSSSESSSSISSSSSRERKRHRKKKRRKESKSKRRHKRSHKKKAKGRKKDEGKSSSGPVQLSKFIKERKKQDNKRSVISGKKIKMKVKKTSKDKERDLNRRDLLNFLNSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YR79</accession>
    <name>A0A8B7YR79_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin heavy chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110981995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095789.1">
        <property type="nucleotide sequence ID" value="XM_022240097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YR79"/>
    <dbReference type="GeneID" id="110981995"/>
    <dbReference type="KEGG" id="aplc:110981995"/>
    <dbReference type="OMA" id="KCGIKQM"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000080">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF33">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="8">
        <location>
            <begin position="89"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="608"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="549"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022095789.1"/>
        </source>
    </evidence>
    <sequence length="1002" mass="110617" checksum="375A4433A97CBAE4" modified="2022-01-19" version="1">MNVSNRHRLRPRPNYDSDSPSSLKDGTGFLADTPGGSSSATSVSSDRRDAFVKKRYNSHSGLSYDSSRLNSAPDSLADDWDLEDGGLEQVNVVARVRPLSEAEIKRGDKDCVKIQHNSSSITLGSTEKSKTFTFNSVFNSRTSQREVLEKCGIKQMIEMAVDGYSCTTFAYGQTGSGKTYTITGPISQDSLMPPQDKYGLIQRSFIHLFDVLGQRSGPNITFTLSASYLEIYNEQVKDLLNPGRESLPVRWSKDKGFYVENLFVVDCETLDDLLGVLEEGMGQRQIATNNINEYSSRSHTIVSLQIDSEMPDPEEESLYITKHGRLSFVDLAGSEKVKELGNSGELLTETTNINKSLLTLGNCISSLSDNRKRSGHIPYRDSKLTKLLADSLGGSGVTLMIACITPSSYCLSESLSTLRYANRAKRIKNKPVVRMDPRERLILSLKREVKLLRNENLYLRQRLEFPKSVKPSVRRNDTEESLSISSFSEDLSSGDRTPIPGDFDRSKGTSDTSLKTEDKRNLKRRETNSSMLSAFTPKSAADSSLYEMLQEYMVENEKLRSENSDLHNVRQRAMTEHEHLSKENDKLLTKLDQLERVFAASPISMSRTVSGISSSPFSGQQHKRSLSQHSSGSTPSSQGQHAGQLPPVDSKRGVPNGYRDSKPHPYGSPGQHQQPSPPHQYRSQPAPVHQPPPMHTSFPGSLNAADGSGFDTGGHRSHKAQHSYPPTQRGSVRQNDPGSAPDTSLSFPPHKTYHSQSSLNSMHSLPEEASPRGLPNPRVDPQATRNSRDAPATGESSQGKLQHKVDIYIPSIPSTSKEANRDRIPKKDPDSPRWDSSHNVNVHAMQERTANNRPKNHPRKPPSKPQGTATSSQAPAVGYSNRSKKNAALLQGKDGSKPSPKMQRRDNAEPASTEQNLDTLPHTPAVTPPPVKYKPKGTSDLLAATSGDLSKPPPDPESLLEINEKLRQELLDLDGEIQYMKYVNKAKGNTTQAPKATKGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTS0</accession>
    <name>A0A8B7YTS0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110982161 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096092.1">
        <property type="nucleotide sequence ID" value="XM_022240400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTS0"/>
    <dbReference type="GeneID" id="110982161"/>
    <dbReference type="KEGG" id="aplc:110982161"/>
    <dbReference type="OMA" id="MEWEEPW"/>
    <dbReference type="OrthoDB" id="10636747at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096092.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="75793" checksum="BC6143F26E96D04F" modified="2022-01-19" version="1">MFPSFCLRRTMDAANKLILTNGTPAESHLPPWSIAPRRCCSCRRKTSSFKLRVPTARPGMASLLINTTKQSFGLLLGTERGVTFSLRHFATSWIVDGEQLAFPILSHESIFTSFFGLLALLVQLFQTGHHIKSRKIPPYHHCLHKQRLHLAGFPIQLMNSPRIGLRAVILPNHAVLLRVLPIIFLPTVEVSVQAWIISFLRDTIYLKTPTIKSPDTTSSQVTRLDNSVPAPLRSCSLRGRLPWSHHIGDFHVLAGFSFLVLFRESHHVTANLAGTGCCLIIAYYIGVRMLFRTNHLRTQITCNTALDTCHAHLLQSSSPNRNHSNNVRGKRSYSQSSSGDFSYGNDGATDMETDETNVDEDMETGESAHKVMEIESDASVSMEIDKVEVNILEVDYDDCDDAGIAMETDDKDDTDMGVDLHEEEKMEWEELLTVRRGFDFTRFHYGSDHVFITQPLHKTSGCAGLKTETMEWEENVSTAGWKWLRVSFSASENSAPASTESPVRAFLAQLPPPPLLSLRRIGTVPHHPSQTATIIFESFTNAGDARQLDQLSLPRGPGPEGTSAIRDNRYASKGPRNRRTRSLKRASFNIMGATTQFKPRHTGFRHSIHNRGQVVRCGQIVRRAIRANQPGQASSGVRLATRFQIRQGHETTSLVRAFTELRLKECDMKLFNGQLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVA9</accession>
    <name>A0A8B7YVA9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110982839</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022097249.1">
        <property type="nucleotide sequence ID" value="XM_022241557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVA9"/>
    <dbReference type="GeneID" id="110982839"/>
    <dbReference type="KEGG" id="aplc:110982839"/>
    <dbReference type="OMA" id="YENAVPR"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF611">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="9"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="108"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="204"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="300"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="624"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022097249.1"/>
        </source>
    </evidence>
    <sequence length="920" mass="101247" checksum="5070BE4F2879295D" modified="2022-01-19" version="1">MAEVMVTTETSTVTLTAVGSTSVKVSWSPVTCAQNYAVEYALTNRDDCEPINSPTYIQHCICQGSETTINDLLSYSRYTVKVKVFVNGAYGPETQGQTTTGTVVPTASPTVIEALSVGQRSLTFTWRPPLCGNRGGVITGYEYMLINLNSRSSTTGTVTGEEVVFHQLLPFTSYSFQVAATNAAGTGPYSDAVNTRTEQAEPTVPLNVHFQSVDNVSVIVEWLEPDPPNGLITHYNVRYWRIEENNNSKTDVNLTELTHRVTDLQAGATYLFQVQAVTSAGAGPWSEAINAMTAIGVPGPIRNLTYTEKTETSVTLSWEPPLKPRGPITAYLVEYRILESLSPPKLTAEVTYQSSEAQQSPFLQGNLSPGTKYEFRVLARNGMFKGTSDYALEVYTKPVTDLPAPPRPTLDQGETTDTTVTISLVAPESEEYIESHVIHVKRLAVLSVNKREVLVPGRYEDPASGYITARFLKHNLPEMFVVGDSKMYGGYWNAPLQRDAVYNIRLGTVSKVNETAVSVTYSEPLTVSVQPREGNEATIAAGVLGAIVLVLGLTVTITCVGWRRQSQEKKSNSSTVQATLELADKPAANPNESAVADNGESVIYEDMGLPSGVQKMEIKRGNLVIEDVVLGKGNFGEVRKGRVQIQGKFNKAAVKTLKDGASDAAVKDFKEELQTMASIEPHPNIVCLLGACFYEGILCVALEYLPNGNLRDYLRSNRPKQKHEKERNTGATPLTSSNLLKFGADVAKGMDHLSKTGIIHRDLAARNVLLAEDLTAKVSDFGLSRGEDIYVQKSSTRIPVRWLAVESLTRRVYKSKSDVWSFGILLWEIATFGSTPYPGIESKSLAKRLLDGYRMPKPENCADEIYNLMLECWQEIPSRRPTFKEINEALKDMNANSDKNIYMSPTIYENFIIMKELDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXM3</accession>
    <name>A0A8B7YXM3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110982834</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:18865"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="2.3.1.168"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:18866"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022097240.1">
        <property type="nucleotide sequence ID" value="XM_022241548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXM3"/>
    <dbReference type="GeneID" id="110982834"/>
    <dbReference type="KEGG" id="aplc:110982834"/>
    <dbReference type="CTD" id="1629"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043754">
        <property type="term" value="F:dihydrolipoamide branched chain acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000013">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000027">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000002">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="97"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="262"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022097240.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="59166" checksum="8CA5DA2299A99E9F" modified="2022-01-19" version="1">MEFRDAMKIWRAQSLLMLEMANLIRQLWIRSSPLQRCTRNLNYATRHFSVCCSSSHYSPHARCTSRRLPSAKLYRPLADLSTSIRCLGMSSVLHGDVVQFKLSDIGEGIAEVVIKEWYVKEGDTVAQFDSICEVQSDKASVTITSRYDGVIRKIHYEVDDIARVGSPLVDIEVTSESSQDVDDSSSMSDSDSDSDGDTIQSGEEAAHEERRNVKVLATPAVKRLAMENNISLADVDGTGKDGRVLKEDMLRYLDMVKSGATTAASAAPPKPPPLIPQAPPSPPPPTPPSVTLPVPPSRPFEPVVVGQDRTEPIRGIKKAMVKTMTAANQIPHFGYCDEIDVSSLMELRGVLKEAAGLRGVKFSLMPMFIKAASMALHYFPILNASVDEQCESLTYKASHNIGFAMDTPQGLLVPNVKNVQARTIFEIAQELNRLMTLGYEGKLGSDDLEGVTFTLSNIGTIGGTYARPVLMPGTVAIGAIGKVQALPRFDEDDEVYKAYVMNVSWSADHRVIDGATMARFSNIWKSYLEEPATMTLDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXP2</accession>
    <name>A0A8B7YXP2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110983279</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022098103.1">
        <property type="nucleotide sequence ID" value="XM_022242411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXP2"/>
    <dbReference type="GeneID" id="110983279"/>
    <dbReference type="KEGG" id="aplc:110983279"/>
    <dbReference type="CTD" id="10299"/>
    <dbReference type="OMA" id="QGRIVIM"/>
    <dbReference type="OrthoDB" id="1108038at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056521">
        <property type="entry name" value="MARCHF6-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13145">
        <property type="entry name" value="SSM4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23113">
        <property type="entry name" value="MARCHF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="803"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="847"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="932"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="975"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase MARCHF6-like C-terminal" evidence="12">
        <location>
            <begin position="833"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="129"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="572"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="688"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="139"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="700"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022098103.1"/>
        </source>
    </evidence>
    <sequence length="1035" mass="114579" checksum="A51EFDDAC41E8CDF" modified="2022-01-19" version="1">MHRFSFTPIYSPDMPKRLPVMDIVRGLAKSMGTAVKCWLHYTLVTFAWLGVVPITACRIYRCLFQASLVPLLTLPFDVLSLESVVTDILQGMLVVGSTLCAFVSLVWLREQVTHGGGPEWLEDDARRAGNGVVDGAGEAAPAAQQQQQQQQQQQQQEQQRPAAAPVNNQNAAPPAQPAGNQEPPAHHQAPANQGPAAAAGDGNQAGAGQPAAAENAANNPPGAENAGQDDINWNALEWDRAAEELTWERMLGLDGSLIFLEHVLWVISLNALFIFVFAFCPYHIGHLGMLLLGWDELAKMSRFEGLLTTMCGYVTLCSSLILFHFFSGLLKLHRTKRILGLCYIVLKVFLLVVTEIGVLPLVCGWWLDICSLSMFETALQDRLQSFQSAPGTSMFLHWLVGMVYVFYFASFILLLREVLRPGVLWFLRNLNDPDFNPIQEMIHLPVYRHVRRSLLSVIVFGSVVLLVLWLPVTIIRYLFPSFLPYHIHLSSDSPVSELSLELLLLQVVLPALLEQGHTRQWLKNIIRAWTVCAAYLLDMRSYLLGDVPLEENLAPTPQHDQQLPHLDQDPEEAEAHLGEDRPHPWEEEPQPEAEEGNLNPDPATPVEGQASVEAKGVDTDTQGLDAYLEGGATGGVIDIEIDELVYREEEVMSSGQDEDSDVIMEEEEDMDAVQMADVAVGNDDHLYEDLQEQGGPLPPDELAAEGPAEAGAPPAPAAAAPAAPAGGMALHAAHHAMINQMGPTGFQPYNKPTFFAMRIILLVHLLCLTLLLASVLCLTLPVFLGRFFMSLWVGKGVVVHELYTAACGLYLCWLVCRLLTVVWSWMPAGMELILEKAKIYTILLIKSLLVAFMLLGIIPFLLGLLFEVVVVVPIRVPLDQSPVFFPWQDWALGVLHAKIMCAVTMMGPNWWLKTVLEQVYQDGFRNLNLGFITRRVVLPVVTCLLLVLAAPYAVAAGVTPLLGLGEDVNLLVVRRIYPCLVTSIITMAAMVFHLKQFKKLYEHIRNDKYLVGQQLVNYDPRDQSKKDHATQTAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXQ9</accession>
    <name>A0A8B7YXQ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aquaporin-12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110983291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022098118.1">
        <property type="nucleotide sequence ID" value="XM_022242426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXQ9"/>
    <dbReference type="GeneID" id="110983291"/>
    <dbReference type="KEGG" id="aplc:110983291"/>
    <dbReference type="OMA" id="HLLVYWV"/>
    <dbReference type="OrthoDB" id="1580043at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051883">
        <property type="entry name" value="AQP11/12_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF16">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022098118.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="29323" checksum="7F2B542DE4E4D5F8" modified="2022-01-19" version="1">MAVLPGGYGAVLFALLATLLCAVARRLIGKFLPAGGCARRYAGEVVCTFQLVTGMLEGDVVMEENGLVAYMVYLWFLFVLLGFTFDDDCSANLGLAWQAWLRGDIDATDAISTSVAQVLGGQLAFPYAKRLWRTAPTARHGIKWQVMIQEQCSSALQASLQGGIVAEALATLVYFAARRHLMPRGKMRSIAFDSTVQVVIIALGLEWTGMMFNPALAAALTFNCRNHPVGEHLMVYWVSPLATIALLHAVTTRGPAIPVTNGTKKEEAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXW6</accession>
    <name>A0A8B7YXW6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase PRP4 homolog</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">PRP4 pre-mRNA-processing factor 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC110982167</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with CLK1 C-terminus. Associates with the U5 snRNP and NCOR1 deacetylase complexes. Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022096106.1">
        <property type="nucleotide sequence ID" value="XM_022240414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXW6"/>
    <dbReference type="GeneID" id="110982167"/>
    <dbReference type="KEGG" id="aplc:110982167"/>
    <dbReference type="CTD" id="19134"/>
    <dbReference type="OMA" id="MNRGDNA"/>
    <dbReference type="OrthoDB" id="3967at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14135">
        <property type="entry name" value="STKc_PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000078">
        <property type="entry name" value="Serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000123">
        <property type="entry name" value="serine/threonine-protein kinase PRP4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044092">
        <property type="entry name" value="STKc_PRP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 28" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="736"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="179"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="441"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022096106.1"/>
        </source>
    </evidence>
    <sequence length="1052" mass="121199" checksum="A039A7215C2A2AB6" modified="2022-01-19" version="1">MEKGMILEEQFLVDNDENASSSSVSESESDGEEKSKGKESIEPSADELNAREHRHRSKKRHKHHRHHHRKKHRKHSSERDDHRHSRRHKHKHKKSSRSSSKSSSRPDGRRRAHKREGVVPYTAEEEGEEEEDGEDTAALADLEKQKELLQAELLNDLGLNNEEELKQASGMAIIAKGYVSSDEEGQVSEGDTRATENSKQQEDSDDDVVIVQEIRGSTRRHSKRGARSKSPEVDRKRNSTDRSKDSRRRRSISRDRSLKKSHSRSSPSTSPRRQRDKTDTSSDRVKRSEQSSSRRISKRSRSRSRDRKQLASPIEVDKPSSKRSQSPRRSKSPKRRRSRSPRTSPRQKSRSRSPRRKPKLVISLESLRQQSPRRSPSPRRSSRGRSKSPSRVRPFGRSSTDRNHSPPARRRSRTPQRLRSPIRIRSPTREELAERRRRRSRSPDLRRRDRDRDRESRRDRDRGRDRDRDRDRRRDRRRGRGNRTPDDKFKGSLSEGLTMKDDSSDEELQDVDLQDEEDEETIIERRRKQRQELLKKLRAPVAPTATELGVPTPDESITSSGMNTPSSQKETEESSSSSSSSSDNDSSDDDDSDSEEEEDQEAADQGGAEGKIIDGMQTLPDPEGVLRDIPVPVGGAERVSESKLSETVQRQDKASVVKVNMEEKEHSSATKTETKAQAKNGMDMFSEKDMFGDNYDSPTVEKLGHTGHENPSLTDNWDDAEGYYRVRIGEQLDKRYNVYGYTGQGVFSNVIRARDSARTQQDVAIKIIRNNELMHKTGLKELEYLKRLNDTDREDKFHCVRLFRHFFHRNHLCLVFEPLSMNLREVLRRYGKDHGLNIKAVHSYTCQLFMALKLLKRCSILHADIKPDNILVNESKAILKLCDFGSACHVGEADITPYLVSRFYRAPEIIIGMTYDYAIDLWSTACTIFELYTDKILFPGKSNNQMLKLMMDLKGRMPNKMIKKGMLKDGHFDGSFNFKYIEVDKVTEREKVTTYSAINPGRDLMGDLVGVGRPDRKLTQLKDLLEKCLTLDPSKRIQIKEALHHPFIQEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY41</accession>
    <name>A0A8B7YY41_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Neuronal acetylcholine receptor subunit alpha-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110982215</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096176.1">
        <property type="nucleotide sequence ID" value="XM_022240484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY41"/>
    <dbReference type="GeneID" id="110982215"/>
    <dbReference type="KEGG" id="aplc:110982215"/>
    <dbReference type="OMA" id="KHAIKYP"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000005">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="35"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="247"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022096176.1"/>
        </source>
    </evidence>
    <sequence length="548" mass="62433" checksum="B7A3A97BA9565C6F" modified="2022-01-19" version="1">MAGRATVRALSALVVLMTLIAVEWIIGCEGSNSAQQLFEDKMRGYDPLIRPVDNNSDVVNVSISLALSQLIDIDEKNQVMITSLWLKQQWKDSKLDWDPADYDGLEQLQVPIERLWSPDILLYNTANGDFAAGLGNWATVKYDGTVYWNPPVIFRSSCLIDISYFPFDEQRCKMKFGTWTYDGSVVDLNPLTQRVERENYRANGEWDIVESPVAKHAIKYPCCEEIFIDVTYTFVLHRNPLFYIITLVLPCILIALLTVLVFYLPSAAQEKVTLSISVLIALIVFLLLIPSIVPPTSTTVPLIARYMLFTMAIVSISIFATVWTINLHFRNSNTHTMGKWTKKVFLNVLPRLLLIERPGASHARKERARQKQMERALIRSNVTSSFVYSPVDAAAAGGRGRKEPGGYSKMVMSGSTLSPSLREEIEYRERSGTLRRYEEYEPVKREWDDLLENLQYIQENLKHADEVEDSEEDWKYVGLVVDRLLLWIFLIVVVVGTAVFFVQAPILWESPDEHKREVYDDPEVLLTAGYYDLFPTDPPIPQAVSQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYB8</accession>
    <name>A0A8B7YYB8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoredoxin</fullName>
            <ecNumber evidence="1">1.8.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110982257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>[protein]-dithiol + NAD(+) = [protein]-disulfide + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-dithiol + NADP(+) = [protein]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.8" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022096246.1">
        <property type="nucleotide sequence ID" value="XM_022240554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYB8"/>
    <dbReference type="GeneID" id="110982257"/>
    <dbReference type="KEGG" id="aplc:110982257"/>
    <dbReference type="OMA" id="NWYSPCT"/>
    <dbReference type="OrthoDB" id="189920at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03009">
        <property type="entry name" value="TryX_like_TryX_NRX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045870">
        <property type="entry name" value="TryX_NRX_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46472:SF1">
        <property type="entry name" value="NUCLEOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="166"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022096246.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="46598" checksum="EA905E15A3F4DDBE" modified="2022-01-19" version="1">MALVDLLGETVAKKDKTTVAVSSFTGEGKVVGLYFSAHWCPPCRAFTPKLAEWYSKFKESANGANLEIVFVSSDKDEDSFKEYFNDMPWLAVEYSNRDKKNDLSKKFRVAGIPTLILLDGATGQVNERDGRGTVMEDPTGANFPWTPKPFEEIFSGSLINNKGETKTTDDIKGKVLGLYFSAHWCGPCRGFTPNLTKSYNKMVEDGKNLEIVFCSSDRDEASFKEYFSEMPWLALPFGDKRKMALSKKFDVQGIPTLVFLDESWNLITTNGRGAVSKDPDGAEFPFYPKAVNTLSGDSASSINENTTLIWFAANKEGAAAYKDLLLPCAEEIINAAKAKGEISPMDFLVACEDDDDDDIMDGLMEFCKLEASQIPFLCIIDIPSQSIYKNCDKKEYTTDELKALVGNYLSGKLEKQKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYN7</accession>
    <name>A0A8B7YYN7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110983477</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098453.1">
        <property type="nucleotide sequence ID" value="XM_022242761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYN7"/>
    <dbReference type="GeneID" id="110983477"/>
    <dbReference type="KEGG" id="aplc:110983477"/>
    <dbReference type="OMA" id="GVMTRPN"/>
    <dbReference type="OrthoDB" id="10355666at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034237538" evidence="1">
        <location>
            <begin position="25"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022098453.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="20149" checksum="10D7F9B48D7C1D55" modified="2022-01-19" version="1">MDLRYTWPLFYGVVLATCILEVGSLQCYECVDMEDLPESTVDCDNPGKELLLECLEGTTQCLTFEGVMTRPNGESQRGVARLCGPPPQAFLNDTARVPDNKCYCDEDAAFWLEELVPVIAPDDLTVEGGICFCGEKGCNYHNSTEDACRRDDEVDDDGNNTGHERALLWLVVMCVSLAGYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZA9</accession>
    <name>A0A8B7YZA9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein DZIP1L-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110983614</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DZIP C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098689.1">
        <property type="nucleotide sequence ID" value="XM_022242997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZA9"/>
    <dbReference type="GeneID" id="110983614"/>
    <dbReference type="KEGG" id="aplc:110983614"/>
    <dbReference type="OrthoDB" id="515971at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058883">
        <property type="entry name" value="DZIP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032714">
        <property type="entry name" value="DZIP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF3">
        <property type="entry name" value="CILIUM ASSEMBLY PROTEIN DZIP1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13815">
        <property type="entry name" value="Dzip-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25977">
        <property type="entry name" value="DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="343"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="488"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="635"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="650"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="745"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="829"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="923"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="935"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="965"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1008"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022098689.1"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114678" checksum="F6A36BAB9163597E" modified="2022-01-19" version="1">MMHGSYYPSPRGAGGGTSYVYTNGHVPNSTPRAVPVTMNGGPGFTFQKRHERIDWRRMASVDVNRVMQELDFATLQDVIMTVTFCDITAEVDMRAIDANFIKLFQLSQLIAEYLLHSQNYLTHSISLTQEKLQQSEEAHSVTRTEVSKVRQEVKKIKEECHKRKKMLKQQQNLIQAGANNYHKCPYCVKAFVHAAYLQSHLQRKHPEYVPPLAESEAKRQQESLEREIEGLKERLRLTESQMEEERKMMQQQITTYKESLSREDSKRLEELQRQQMESWKREQLESQRSEMERMQEMFMKELKEMNEKYSSSQLALEDLQSKYGKKSMLGTLQDEDELADLREQVKKLKKENEQRDLDLQNKLVSTQSSMREQAKMFKDQTKQMKRDHKDDMQELKNQLDQAEAALRIEREGGSNIGKKYEKQIQQLLQESKEQKKVLRSKEEEIKSLKARPPPVSIIPEVKPAVVSNTPVNTGQQVLQAKRLDLIYAQKSPAKPPPSPPAKKAAPILAQSLSSEEEEESDDGIQSNEEEGDISMKSSQELASSDTEDQFSDGEITITDNDNDNDLLGDERLTLKQDLVSLLKRNLEKQGVPEGVNGITSNSLDNKMRRLKEQRQALARSHPHFREIRKSLKEDLERMLAERQRGVRKMTSSARPKSTSPKPRSSANVSKDKHSASRTQSQAKSSMPSSSGVKLSGVGHTQLSIKEPGRQVPPPVAPRNSEMPKSSSLKSGSKPPGSPARVSFDVTDDGDFESDVDEDEDDSLDDEEDESELSLDEDSPDTNINRRPAASIPASSVIPPQPAARGTAEGMDDDSDWDSEDVSELEEMSQNERGKGGHEQHRQQQQRQQQQGRSSRPMPAGRPKSPAIAQKAQKIEQLLSQRRSDHKPVGGVDLGVKSQSSNLRPDSRDEGRSPSPRIPTLPDASDEEDDDDDDSFAVSSLDGSNYSVPRTRGPPVPVPAPRQGSRPPTTGSRKSDTDMSNTYGTSMWGSSKGQGESGTAKSSLVSVTDFDDDDDLDLSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZC5</accession>
    <name>A0A8B7YZC5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 11">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110983619</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 11"/>
    <dbReference type="RefSeq" id="XP_022098703.1">
        <property type="nucleotide sequence ID" value="XM_022243011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZC5"/>
    <dbReference type="GeneID" id="110983619"/>
    <dbReference type="KEGG" id="aplc:110983619"/>
    <dbReference type="CTD" id="4351"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.441.10:FF:000001">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000044">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000030">
        <property type="entry name" value="Mannose-6-phosphate isomerase ManA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="95"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="256"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022098703.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="55095" checksum="6949702F49823C8A" modified="2022-01-19" version="1">MASRSNVRTEMGSLVSKKKQPPPAKGDSSSTPQAAGSPASPPAAESEVKDQGVSTPAALPDEKVNKAPPQEGGAEEVMVDDESPVTVTQTPVAVALKCAVQQYAWGRIGKDSEVATLTQACDPSFQLKEDEPYAELWMGTHVKGPSIVEGQEAKSLKDWIADQPDCLGEKVRSKFNDQLPFLFKVLSVNKSLSIQAHPHKALAETLHAEHPENYPDDNHKPEMAIALTPFEGLNGFRPLIEIDNFLKTVPEFRAVVGEDNADKFTAELEAGGSDSKNVLKDCFTELMTRDPEFVKEQLALLVQRLQAEDSETGKNRELLLRLNSQFPGDVGCFCSFFLNHMTLQPGEAMFLGPNEPHAYLSGNCMECMACSDNVVRAGLTPKYKDVENLCKMLTYLPSPAQDRLFPSVTDPGDACVTIYDPPVPDFAVARIKVAEGVESYEVTAYDSASIFITISGQAEASHPSFGNGKTLTLKRGSVIFMSANHSLPLKLEKADGLLAFRAYCPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1F6</accession>
    <name>A0A8B7Z1F6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110983986</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="RefSeq" id="XP_022099434.1">
        <property type="nucleotide sequence ID" value="XM_022243742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1F6"/>
    <dbReference type="GeneID" id="110983986"/>
    <dbReference type="KEGG" id="aplc:110983986"/>
    <dbReference type="OMA" id="QSEPYDS"/>
    <dbReference type="OrthoDB" id="6072411at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23437">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000053">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF68">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 17" id="KW-0430">Lectin</keyword>
    <keyword evidence="16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="18">
        <location>
            <begin position="468"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022099434.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="68217" checksum="EC6631C3E676E070" modified="2022-01-19" version="1">MRYLTPRHRQRLLLVVGAAFIVSVFVLMTLDPDTTTDIPGPRELHGHGIDVPNHQPQSRASVISLPVLNKKQLGNYESRIPPPERDGPGEFGRAVKVELGEGSKYRKSIREFGFNVELSDEISLDRVVPDIRDPECKYWHYPEKLPNASVVIAFSNEGFSTLMRTVHSVINTSPPNLLAEVVMVDDMSDKEHLGKKLEDYIKRDRFQGKVRLVRNTKREGLARSRTNGAMAARGQVVVFLDAHCECSVNWLPPLLAEIAYSRTTVVCPTVDVIKAEDLSYSPQGELARGAFDWAFWYKRIPVDYSDTMKRIGMKYGSQAYDAPAMAGGLFAMDRSYFIELGTYDPGLFIWGGENFEISFKIWMCGGQLKFVPCSRVGHIYRRGVPYKYPVVDGEVSIVDRNFMRVAEVWLDEYKEHFYTFKPRLRGKSCGDISEQVAFRRKHCPKSFKWFMENVAFDSLELFPTPPPNRAWGEFHLKGTSLCLDTMGRQTTTQLLGASNCHGYGGNQEFRLGTNGQIQFDEYCVVPSWDQTKVSMVRCRESHRKVPDRDHWSFSEEAGQIRLKRSNLCMEVVDKKEVRLRDCNSDSAEQKFEVRQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z298</accession>
    <name>A0A8B7Z298_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110984164</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">COPI-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099738.1">
        <property type="nucleotide sequence ID" value="XM_022244046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z298"/>
    <dbReference type="GeneID" id="110984164"/>
    <dbReference type="KEGG" id="aplc:110984164"/>
    <dbReference type="OMA" id="DFIEDCE"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000038">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000001">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="25"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="14">
        <location>
            <begin position="612"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022099738.1"/>
        </source>
    </evidence>
    <sequence length="752" mass="83772" checksum="332558087F0C5646" modified="2022-01-19" version="1">MHMLRRDKKDEEDGGSSNPFQNMEKSAVLQEARVFNETPIKPRKCCHILTKIMYILNQGEHIGTTEATETFFAMTKLFQSNDVMLRRMVYLVIKEMANIAEDVIIVTSSLTKDMTGKEDMYRAAAIRALCKITDTTMLQGLERYMKQAIVDKVHSVSSAALASSLHLLSQSPDVVKRWVNEAQEAATSDNVMVQYHALGLIYHIRKNDRLAITKLVGKYTRGGLKSPYATCMLIRIASKLLEDEDAGNDSPLFDFIEGCLRHKSEMVIYEAAHAIVNMKNTTARELAPAVSVLQLFLSSPKPTLRFAATKTLNRVAMTHPAAVTACNLDLENLITDVNRSIATLAITTLLKTGSEGSVERLMKQIATFMSEISDEFKVVVVQAVRSLCSKFPRKHGVMMSFLSNMLREEGGFEYKRAIVDSIIVIIEENPEAKEAGLAHLCEFIEDCEHVSLATRILHLLGREGPRTQNPSKYIRFIFNRVILESAAIRAAAVSSLAKFGAHCESLLPSVIVLLKRCLLDGDDEVRDRATYYVRVLEQQQKALNSMYILNGLSVSIVGLERALHHYTLSPSETPFDMKTVPLETQPITEQKKPDLLPSAKPADKPSAPVQEIYAEQLAAIPEFASLGPLFKSSKPVELTESETEYMVRCIKHTFANNIVFQFDCTNTLNDQLLENVTVQMDSSDGFETVCHVPAASLKYNQPGVTYTCVSMPEDATSVTGTFTNTLKFLVKDCDPNTGEPDDDGYEDEYVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2Y7</accession>
    <name>A0A8B7Z2Y7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110983843</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110983843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099135.1">
        <property type="nucleotide sequence ID" value="XM_022243443.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983843"/>
    <dbReference type="KEGG" id="aplc:110983843"/>
    <dbReference type="OMA" id="MPHNIHF"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056602">
        <property type="entry name" value="Beta-prop_LRRK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23748">
        <property type="entry name" value="Beta-prop_LRRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="529"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1144"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1225"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022099135.1"/>
        </source>
    </evidence>
    <sequence length="1446" mass="163576" checksum="A1CBA9EA2F8357F3" modified="2022-01-19" version="1">MAEEKVVHSGYLLHRPGGALGRWKKKRYWFQLDEVSCQLRQYKSQAELCHTVGTVDIRDACISILPDHQNHILVACRGKEHILIAENHRSMMQWLQNLQEVRDLFSCVKSNRNQVKLSRTLTYKPTTASPSKGLASSPASSLRRQHSARGKSKNLGDLPASFSASVETNDSYAAFKKNLVGSLSIPSNKNSFIYDSLETSPTSMRSCNSIASHSSTEELPTSSGWTSPSGGQAPTDASDQSERGATEGECPEPKLDGAALEDSGSIKTWRQLDKEALIEQLQQMKQLMEQSKKNFKSLENREQAYKQMLKKREQDIMHLDDKLGIMEQAHHLRRDLLSPEDMDAAQQRILDLQDTCKVYQEQNGFLNTEVRRQASLRRREQVKLDIQNRLIDGLEGRILQSQQDYFQLLGQVIKVTSLDPKDDIPLPLSWEDKRLKSFLELFHEARQQDPCLPDPRVVMVEGYTDIYGFQHPTKNQPLLLHYLCQILQDHLLAASRRSTELNKKWEECASNGNISTLKQEELRELVYEGIPTDYRSEIWSHLVLQRVKQLKAEKSEDYFQWLCNRTGTSSSVDKYRRQIELDLLRTMPHNIHFNNKDAEGVKQLRQILEAFCVHNPTVGYCQGMNFIAGTCLLFMDVEMAFWCMVAVVESYFPANYFDSSLIGAQADQNILKDILELRLPRLHAHLDDVGIEMCSFTLNWFLAIFFDVVPFTMLLRIWDCFLFDGLRVLFQFSIALLQYHETSLLEKKDILAILKDTKSMAKLTQDVQAIVNLVRESNDSFPSSAWIQQKQQHYMSVLRAVYEQQEKAREEFEKQEGLAPAMPVFQREGEDALVNDLKMDCAVECYSGHLLVCRGELRQGWVGRVNISKCIKQNYGIRLDNRIVCLTMAGIDMALLGTVSNFLYAFSIGTQEELWFERLRDTPLSIVHDQQTRNVYIGLADGTMAVIEGVSHASPRDIFYHGIGAGPVRSVLYLPELDQIWCACGNAVNILDNSLNVTDGFEISKCPDIHISGLYRSDHGVWVTVRGSAIVMLWDPRQLQCLLLHDTSMDQTPIHTKPHENHARSKITSLLPYENTLWVGTADGHLTIYKIDKASMPKSGMTLENGDHNSAGESEGSDKGLKEKSEKEQPEAETLETARGEVDGGGDGDEDDEEMKPQDTSSQTLKEFVIVESSEGLPESQPGSDTDTKSKNHLPHLAKLQDTVGTVTSSDDEHRSKPKPGPSKAVRKHRKGSRKGGYKGGPRDSPRALRKVWQTRQKSSASSAERPEPELLSPRTSKTMEKVQSVFGKFSLGTTPKSKQYRYSRELRDETRRGSRICVTDATEPSTSAMSLMSLVDAESTVLRPPSVLSRDSLSEVYAQYASRPRPPLFDASEIEVRPGYELNIEAKRKISDHQVRCLVLTSLEDGNPAIVSCAGFYGDDESMLRWTCHTRENVWMQVPIEDTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4X9</accession>
    <name>A0A8B7Z4X9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 12-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022100012.1">
        <property type="nucleotide sequence ID" value="XM_022244320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4X9"/>
    <dbReference type="GeneID" id="110984296"/>
    <dbReference type="KEGG" id="aplc:110984296"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="32"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100012.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="45861" checksum="95E9C5787F6B6A74" modified="2022-01-19" version="1">MPTRNAQIKEFQPGKSMMREKCSTRCLQGFYIVVCMHISMMLLSGFTKGLGVMLATLREEFIADTWMIGSLIAGMNAVAGFAGPISGPLHGSFGTRTVVVISGLLSGASVILSSFSTSVFHVALTLSLLTGPGLSIISILTRAMAGRHFTTGYAIATGIGSSGHAVGLVVVGPLTQVLLDTYGWRGALLLLGAISLHLGAFGFLLRSAPESTQKENEYLPLVSTEEEEPAADQSRIPNGEKKSRFHIKKDAIIARLNLLGWTICCCAKFWIAFPVFGCDYITCDLWLMYFVVYAETKGFSGYEAVTFTLAGGIGNIVFKIVLGLILDRGLLNLRLSLFSTIIASSLGLLTLPWINTYWMMMVNAFLFQGLSGMTATMSDIYTRDLFGAEDLVPAFSWIGVFTAALALAFGFFPGKPRLYFKNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z592</accession>
    <name>A0A8B7Z592_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984688</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100803.1">
        <property type="nucleotide sequence ID" value="XM_022245111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z592"/>
    <dbReference type="GeneID" id="110984688"/>
    <dbReference type="KEGG" id="aplc:110984688"/>
    <dbReference type="OMA" id="MFAMYLD"/>
    <dbReference type="OrthoDB" id="2139939at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044688">
        <property type="entry name" value="SCI-1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34117:SF1">
        <property type="entry name" value="STYLE CELL-CYCLE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100803.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="42233" checksum="69EAFE91CD68210B" modified="2022-01-19" version="1">MGSNSRVKDKKSSSKRRASSSERSSSSGSSDSYSSSSESESEVKFKKQKLDSSTKKQRRREKKREERKKKKKELNKISKEDFYNKSTEFRLWLVEEKGKYFDQLSGSKAKSYFKKFVKKWNSGKLGKKFYRGIDHEDARTSLTRYKWKFAEVHTPPKKLDIAKYGDRHNTTRAGEHLTPVADALLKPRTFSTFGKPSVASGSAEDDGQRVIGPTLPVIAQGNTWPVQGPMLPGSTFSQAGREERQERNAQQLRKERRDFRKHNEMVMEELVPKATGHEAKIEKRLGRAEQRRRRGESPETRESFLYGGKSDIQSQLAAQRQKKEQRRERLEDRAASKLEEYRAKEKAKMTALLEQARANKSENALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5D2</accession>
    <name>A0A8B7Z5D2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotubularin-related protein 10-A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100843.1">
        <property type="nucleotide sequence ID" value="XM_022245151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5D2"/>
    <dbReference type="GeneID" id="110984716"/>
    <dbReference type="KEGG" id="aplc:110984716"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14537">
        <property type="entry name" value="PTP-MTMR10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022587">
        <property type="entry name" value="MTMR12-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF110">
        <property type="entry name" value="FI17948P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12578">
        <property type="entry name" value="3-PAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="3">
        <location>
            <begin position="275"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100843.1"/>
        </source>
    </evidence>
    <sequence length="842" mass="95673" checksum="304DB946F88746C2" modified="2022-01-19" version="1">MSKNDKPTFKSYLNSSLFVESKKEKTSKSKKGPTFQLHIPPVDDSHDEIPEPEAFVHGGELIIGQAHNVLKFDAFSGLNRGISGSLYCTNFKISFVSANRPTHHLIELDRKNQLFKENDIPLTCVDTIFQVSSSKRKQLQPGTNASRSIKMVEIKCKNFKVHTFSFKFTNKGQVKSVMNTILHYAYITNLHRLFAFSFELPLSSSSLSSSKATNHATDSQNIKGGKEWKSLNAKKAPKVAQVTAVYRPSSQRISAISDMPERSEPMERAGRTPQFRRYEDWQDEIDRTGARNLRVTAVNQDFRISESLPEVFVVPSVVSDGELIQAAPHFEGGRVPMWCWSHSNGSMLMRAVPLRAETVHSDHEINMLGSLTLIHPSKAQPDVLDLGRLCPSYRDIQTSFQRLHELCMPAQNKKNLKEFWNSDKDWYNNLDATKWMQNISMCMSVAVTAATTICQNEQTVVLREPNGRDTSCIVSSLVQIILDPYCRTQLGFQSLIQREWVIAGHPFLERCGHLTPNDGEEAPTFLLFLDCVNQMMQQFPSAFEFTDTYLITIWDSTFAGIFGTFLFNGERQRVRTCMQDAENPIRLATVWAWSLQYSREDQALFNNPMYIAKQILAEKVPRFRPSSQKEVDHMEGCNPALYRFRARTAKRTILDAKYGSKSQDDSALSTPVHLRDKNLNINGANSTGNSRSSELDPNMIIPQTGPPFIKFWTQCYLRWLPSAHIVGGGYPQVYKQHCQVVDEILQLKEKLDQLRARKMNDVVRRPKRESRLYFTYEDNTRNQGLLTSAFPFSISDLSLIGGDRRSFLGTPLARFLRGQSLMQSDMSMLTATDAEANDEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z775</accession>
    <name>A0A8B7Z775_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EF-hand domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110985073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101498.1">
        <property type="nucleotide sequence ID" value="XM_022245806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z775"/>
    <dbReference type="GeneID" id="110985073"/>
    <dbReference type="KEGG" id="aplc:110985073"/>
    <dbReference type="CTD" id="114327"/>
    <dbReference type="OMA" id="SCGEEMM"/>
    <dbReference type="OrthoDB" id="10255210at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060285">
        <property type="term" value="P:cilium-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000002">
        <property type="entry name" value="EF-hand domain (C-terminal) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000003">
        <property type="entry name" value="EF-hand domain (C-terminal) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.170:FF:000001">
        <property type="entry name" value="EF-hand domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="EF-HAND DOMAIN C-TERMINAL CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06565">
        <property type="entry name" value="DM10_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DM10" evidence="10">
        <location>
            <begin position="87"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="10">
        <location>
            <begin position="235"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="DM10" evidence="10">
        <location>
            <begin position="412"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="575"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022101498.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="74632" checksum="7456F42AC03D0F89" modified="2022-01-19" version="1">MALPFLPGNTFTDPTKRRFHRSQSLGYKNGYALANRPEVGIGGEPLEVNQLSLAELEELNNKRPTLTYGQAKQAPPEDFIPAHVAFDKKVLKFDAYFQQTVHESRNEYYRVRPVIIYYYLEDDSISVVEPHVENSGMPQGKLIKRQRLPKNDQGDHWHWKDLNVDINVTFYGKVFHITQCDKWTQEYMASEGIELNPPGVLPSDPYIESRKESAALRTYQTKSTFDKLKQFLDLDRKVLRFYSVWDDRESMFGEMRPYIIQYYLVNDTVEVREVHEPNDGRDPFPLLLKRQKLPKDRYNVESSFPAVVMELSDHEIKQWCTPEDFMIGKSVFIYNRPFLIYDMDEFTRAWMHNRYGMRDFTPVEVTGQAKQLPSRNLPPYNGFGSLEDSLQSCLSLVPQPPKKDFIKMLENDHKQLRFEAVLDSVKPEDRGRRFIISYRLADDMVTIFEPPVRNSGIISGKFLEPTRVTKPASTPDNPEFYGPQDMYIGAIIQVFSHRFLITNADNYVLTYLEAHQSDFPGSERTIESIRLKRSLGEPAARTSVKGAPMKIKRSPGDLKNLIEEVKAQLRKDNYINFNSLTEAFLQYDRDRSGYVDIGEVKKICQKQNLPLDDDLMEALIAECGGDEQGRIKHAEFMRFLTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7U3</accession>
    <name>A0A8B7Z7U3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984726 isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110984726 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110984726</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100864.1">
        <property type="nucleotide sequence ID" value="XM_022245172.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100865.1">
        <property type="nucleotide sequence ID" value="XM_022245173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7U3"/>
    <dbReference type="GeneID" id="110984726"/>
    <dbReference type="KEGG" id="aplc:110984726"/>
    <dbReference type="OMA" id="QTSACER"/>
    <dbReference type="OrthoDB" id="6095748at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024812">
        <property type="entry name" value="TPR_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47050">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47050:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 24-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100865.1"/>
        </source>
    </evidence>
    <sequence length="830" mass="91976" checksum="86391C62C06050FB" modified="2022-01-19" version="1">MHENVPPAIPIMDSSQVYDDVEMLTKAGSVEVTKCNITKAVSKYQEAYEIAQRLGSGEVYVSCACNLGAALLSQGDPDSAIQHLDQALKRLEEEEPPKTETLRGDILFNLGLAHAMRKDLQSAIQYFCNAIHVFRECSDLKGFADSCQQCGEQHVKLSQLLKAAKYFREAAEGYHNSGRAFLAAKMVVRQGQCLHDSAKSEESLSVLHDLEKFYSQIENSTTDSGKLAKLFCDAGCLLFQLRSPKSACVWLHRALDVMRSTKHSERSNEKLEARILLALGEACSALCDFTKAVMINKEASALYGKLENKKARGKSFYQLAEAYRHLGDHHSAEKYYHIAYQTLEDAGLHGFLWQVLEGLADLNYQRRQLDTSISYYKETVTQLSHSDAHPSIQRHIVSKLATALEVQRVGVVKAEAYKKRVPVLVEPEKDLGQPVSHKNSSPDIPVIQSPIYAPLTSTRLSLYSSMDHSVDKRTRLDVPGRKKKRKSKRHGRRRSGSFDRPVTKGVGEYDTETDISLVGRSKKGKKSYYSKLSRLESEEVKSTGQNKVAPRRLLSHIKGLEIDEDGAAPTVSSVDDSTQMEVSPVTKHPIHKGLNTDSFSESDTAPNRGRSASQTVITDDDSSSSTSNEDDDIEDDSDEDDSLTQVSSDEDGSEYSSQDDSEEDTNNFEEELKHLSESPRPGLGNTYEYPSTSEPMYATIKSRKLSSGQAKDRLYESLDSTASTALLTSTIPKRSAPSLPSPPEPPRGPRPSQRGDSQSKDEKKPARASWDGATYPESSVLSILPRGQREIGLYQVARLEQERRATNSRSSISTTTSEAKVPKSRACIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z877</accession>
    <name>A0A8B7Z877_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Low-density lipoprotein receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110985266</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101868.1">
        <property type="nucleotide sequence ID" value="XM_022246176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z877"/>
    <dbReference type="GeneID" id="110985266"/>
    <dbReference type="KEGG" id="aplc:110985266"/>
    <dbReference type="OMA" id="GDCIPEY"/>
    <dbReference type="OrthoDB" id="6684038at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF8">
        <property type="entry name" value="LD11117P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034449056" evidence="8">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022101868.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16691" checksum="073A5CFD7EBD759E" modified="2022-01-19" version="1">MTYLTTFLLLAAVLMVRSTPPSLSFEYSDDTMFECTNDAIHCENKYGDCIPSYWNCDDVADCKYGEDEQDCHSSSSSQYRDDMFECTDDAIHCENKHGDCIPEYFRCDDIVDCYDGQDEVGCDENKKKRVRIHQGSQGRARGRGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBK1</accession>
    <name>A0A8B7ZBK1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110985468 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110985468</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102199.1">
        <property type="nucleotide sequence ID" value="XM_022246507.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102200.1">
        <property type="nucleotide sequence ID" value="XM_022246508.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102201.1">
        <property type="nucleotide sequence ID" value="XM_022246509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBK1"/>
    <dbReference type="GeneID" id="110985468"/>
    <dbReference type="KEGG" id="aplc:110985468"/>
    <dbReference type="OrthoDB" id="542946at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102201.1"/>
        </source>
    </evidence>
    <sequence length="1215" mass="138116" checksum="5B887569042141BF" modified="2022-01-19" version="1">MASQYNSRQSLRGRPPAAPSRRWSTVGQPTGKANYRPMTTSMSRRPSQQQQQRPLQQDSIQEAERSETTPTENKQLSNPVPPSKKRYSYRQPSDPKVAAEIEVLTKYMTETNLMNAMMAVCQSVLRQESLPYNPYPEFVRQIRHDAERFHMFAQTTKAIQATLTSQLQSTTTPHIYGVKGHSNAWGLEPVINAVNPQALKRYDSLIEDETPTKLVLSDEQQEYSGQILVAIVGPAAFTGTIYHEVPSVDLRVEYIIYGPDVQTALLIFNSCISEDIRRHLSTDCPHKILGILVPKSGPNSQVTNSSEIEFWTVEQAREKWDEFWDTVRDAVLQKRPIVIQCLFLLDHENNEYRTGNKQFILHFVETSENSEKEKFRSFAELPYMTLYEGVFLKKAHAEAYVMTLKRLQDNTNQTAANRQRPDMEDSLASLHEAERDDGNDLIYAGEVREPIREKWQRQIAKLHPVRDAFRLAHLTLLLALSDSSVEGSEVRIEVYRFLHSTAASFHTTTVLNSTLQLLAHTTNQKNSDDQRLLTKQFAEYKTRLLATVDPELHARSSEFHVAHTVLGKVMEQMLAPDSSDPSKLILKSLDLNTLQFIQNYCTSLQFLLIEDAMFFFKRLNFKTLVSGCREAFNRQAAGTTNGSKRKPHQGKSSKSNTSIAASTPDPVKINHGVEAKEIVQQRNIVIDVEEVKSFSNWPRIMVTEAVLMQFMVDVKLDQVWLEFLLELMTGDRLPPNPYPRLVTVLRQAAHRMQLCSETNSALSSKLLHPEQVRLVDHINTIHGVTSIGAYGLSHCSLAGLDAEPLGFVKIAKLTDKLANREVAARRGQFQIAVSQAIGKNCAFYGRLVPYINILHLYDHYYIRGNIGADGDAIQLYAKLVYDYITGVIAQNQYVVLGVYFDDSDRYMSDEDLETEKATFLSHVVDAARKKEDVYLKIYQPIGWRYLCMHKHFVLHYLFVDNTEDRHECFSPDNPSTIYQFVFLSLEEAAAHSRGGRPKQLGNIEATANMKRVSDYLNKEIEGALQEHQVVQAYELIICNALISKDKEFIANAWRVLHSVAYQLNYIQIINRDLQTLVQHALTFPKKLVRAVPSNQSLTKGRGNKTKGEAEPTSQGPFTDTTLSRFFNAYCDKLSSILQDPCAFVPSSLVEMIQEKLKTVTDINNKTSKHTLRIELETVVTLKEVYQLVQPVQDWTSFDIHQAISQHAHGNEAPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCJ0</accession>
    <name>A0A8B7ZCJ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short transient receptor potential channel 4-associated protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110986088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103399.1">
        <property type="nucleotide sequence ID" value="XM_022247707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCJ0"/>
    <dbReference type="GeneID" id="110986088"/>
    <dbReference type="KEGG" id="aplc:110986088"/>
    <dbReference type="CTD" id="26133"/>
    <dbReference type="OMA" id="YNSCICT"/>
    <dbReference type="OrthoDB" id="1866965at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022162">
        <property type="entry name" value="TRPC4AP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31743:SF1">
        <property type="entry name" value="SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31743">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL 4-ASSOCIATED PROTEIN TCPC4AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12463">
        <property type="entry name" value="DUF3689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022103399.1"/>
        </source>
    </evidence>
    <sequence length="777" mass="89227" checksum="D5B8B5ECAAEB904B" modified="2022-01-19" version="1">MEDQERGNIFLKIRNAQLGNAPIRCVSEIPQPILADCDDRLGLENGEQIPARISGLYQCAQNLLDRHRTTNEQYLLCISKLKFLKRLLNSESSQEYPRRSGQTRESRVIHAEVIYLFGGVEVMVQLLLLPQYYPLLKSENSKAFKAESELRTRLAYQVLDVLHFMCICMGPDIAGPLSEREGLILHLFSLMSEKACFLKAATLLEDILGVKQTMISLDKIPKLDSLVDSFDEEQVANFCRVLSIAVSDTDGRDEQLNLVAQDRANRNRTGVPISDLNQEILVGLPNFVMKLVQIACKRIDTPSTSSIPNLYSEIEGWVTWLDSSLAFDALAEVATEEEVFLNLPLNDLSAPIPQSLKTMHELVYKVEVLYVLCLLLTGKQRTKVHEMLSKYKLMAGLNVLFDKVIWRCNLRSQPMHGLNENCDCSPEVALKVQFLRLVHSFCDQNENKYLILTRSEINELNRISTSANLPPLEAVRDIDRSLLCTGPKGILTKLVDVLKKEPAESPFRFWMSRSIESFLRGKTSFADQTFLLRKGLLEAIFTNINSVGTKSKEVLQSNFDLLAELMKFNHIAFKRFNKLIDTQEKLDSFLKLVTENIVDSNMFVRCLILTLDHFQREQPDNYEYAMRSCRLLQFIRKREMRIRFLIKLINTVHVEILTQENVSCLNTTIIFLMFAERSCELPQYLSELRDEEQSQLKPGFLLQNFRELVFFWRDHYLHKDKDSSQLEKSSCIPFEKWTAIANILVSSDVTSTYTIAHYLNKDDLLTKDMDVDLPRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCP1</accession>
    <name>A0A8B7ZCP1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110986113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103449.1">
        <property type="nucleotide sequence ID" value="XM_022247757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCP1"/>
    <dbReference type="GeneID" id="110986113"/>
    <dbReference type="KEGG" id="aplc:110986113"/>
    <dbReference type="OMA" id="CQVLNIK"/>
    <dbReference type="OrthoDB" id="10524122at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022103449.1"/>
        </source>
    </evidence>
    <sequence length="819" mass="89719" checksum="69672784B47CFB7C" modified="2022-01-19" version="1">MDHWMRNKWIEKVLSKFDRNAVTPISDDQEPLACQVLNIKVLDKVVGSIGGVAEVHDCELYIKALFSVDAIRRFEEREESTSCAEFVELRNSLLDLTRYHIMVDVQQQIEKSDIAICVEDFAMTVYKALPGTWRTPLQPAIHHPTVAHDLRRMWRAKYAPDEPDTCQSQDQSQDSPDKCTLSVLLEAMENTSQQASELSEAEQDQPIEGPTGTLKSPEESEETCASRVAFELGSAGCDESGQGTVEALEKAVKEVETKLIVAKNFPELAERIPEYLRDAQGFSVEDLPQDEELDLSRSELLECWISEEALEKLCGIEEWKPDYIPPSSLPVVSSSSSEVISFLTEPSADNQAEKMPKDRLEDPSQDGVTQCGSKRKLSSWQIGESPHKAAKNSVSGQGGVVCAGDVDCEAGADLGESSEMVLDIDDPDREVVTEPSDKQTDAEAASKEGRADRRISCNCESSPEEEGLTALCQCLTPLEEALGETENQVNQQDESLVSNTDSTDTSLVVSCEMPSQSVNSDPDKDQEDLVIFHKLLNVSSEAESLLGVNDMPVTVDSSMSPAQTGRNETLQCSGERPVTTSCTSDTNSKDAAEHVEPSNTIDEPEAAGQMADTSAEVLLVDAEILNVEHVSNSSGQRDVDTSPLPAALKQRANSTPSKTVSEQVTDDPAKPQQVPDKCKEASNTGPSCLPSTTRTVQTNWSVNVIPLKKTVSSTASQKATSESRDERPGHRPITQLRSPVILPSISTPVHSLTSHQPRRTQQSETASSLNTNEGLTGTRRCTSRDGEVDPACTRQLSEQVEDYVLEWCASYFQRLNRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEF9</accession>
    <name>A0A8B7ZEF9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21 22 23" type="primary">LOC110985992</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022103240.1">
        <property type="nucleotide sequence ID" value="XM_022247548.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103241.1">
        <property type="nucleotide sequence ID" value="XM_022247549.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103242.1">
        <property type="nucleotide sequence ID" value="XM_022247550.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103243.1">
        <property type="nucleotide sequence ID" value="XM_022247551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEF9"/>
    <dbReference type="GeneID" id="110985992"/>
    <dbReference type="KEGG" id="aplc:110985992"/>
    <dbReference type="OMA" id="YMDFPPL"/>
    <dbReference type="OrthoDB" id="1022360at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034329">
        <property type="term" value="P:cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06647">
        <property type="entry name" value="STKc_PAK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="260"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022103240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022103241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022103242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022103243.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="59702" checksum="3539506729BDC8D5" modified="2022-01-19" version="1">MSDEMEESPPAPPMRYTSTGGTLKGDASSPGSKPLPSTPTDDEKKKRKIKMPWQGKNEDKSSKQRPEISYPTSFEHTVHVGFDSVTGEFTGMPEHWAKLLMSSQITKTEQKKNPQAVLDALKFYDDSNSNRNEKFMTQQKVILSSNNKGSLEDSFEQTSLNAKHPPKSHDDEDEDDDDEPAPAIAPRPEHTKSKYYSRIEPPPPEVTPAPASPPPVATTNSAEGNVQRPRERQKKKKMSDEEILEKLRQIVSVGDPKKKYTKCEKIGQGASGVVYTAIEVGTGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEFLAGGSLTDVVTETCMDEGQIASVCRECLQALEFLHRNHVIHRDIKSDNILLGMDGGVKLTDFGFCAQITPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPEIQHPERLTAVFKDFLSKCLETDVDKRVGSSELLQHPFLKMAKPLKSLVPLIMAAKEASARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEH5</accession>
    <name>A0A8B7ZEH5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110985999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103255.1">
        <property type="nucleotide sequence ID" value="XM_022247563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEH5"/>
    <dbReference type="GeneID" id="110985999"/>
    <dbReference type="KEGG" id="aplc:110985999"/>
    <dbReference type="CTD" id="10980"/>
    <dbReference type="OMA" id="LVGWWST"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000017">
        <property type="entry name" value="COP9 signalosome complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="35"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103255.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36080" checksum="E26E4435F0007650" modified="2022-01-19" version="1">MATKMEVDETPSTSGDESGSNSVMASSGTTGSVSVALHPLVIMNISEHWTRIRAQEGKPTQVLGAIIGKQQGRNIEVFNSFELLFDLVCGDIIVDREYYNTKEEQFKQVFSDLDFLGWYTTGGPCDALDIKVHKQICAINESPIFLKLNPLARHTDQLPISIYESVIDLVNGEATMLFVELPYTLATEEAERIGVDHVARVTTNETAENSSVQEQLTAQHSAIKMLHSRVKLILDYIKAVQAGEVPHNHEILRDAYSLCHMLPVLSSERFDTDFYNQCNDVSLMAYLGTITKGCNTINQFVNKFNVLYDRQGMGRRMRGLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF80</accession>
    <name>A0A8B7ZF80_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase E3D</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">HECT-type E3 ubiquitin transferase E3D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">UbcH10-binding protein with a HECT-like domain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2C-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110986167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Independently of its E3 ubiquitin-protein ligase activity, acts as an inhibitor of CPSF3 endonuclease activity by blocking CPSF3 active site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with UBE2C/UbcH10 (E2 ubiquitin-conjugating enzyme). In vitro, interacts with cyclin-B.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022103510.1">
        <property type="nucleotide sequence ID" value="XM_022247818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZF80"/>
    <dbReference type="GeneID" id="110986167"/>
    <dbReference type="KEGG" id="aplc:110986167"/>
    <dbReference type="CTD" id="90025"/>
    <dbReference type="OMA" id="KAHATYR"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103510.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="51417" checksum="A33AFB0975483AA6" modified="2022-01-19" version="1">MAAPMNLLGVFVEVRQQIRAVQAVLCINTSFTDEDSCQMDTTGSQELSRLQVEICPDSLHFITAPDGCRHVFPLAPIRILPKSCNGLHWVQDEGLHMRLQLAGSREAGDRREMDEAWEKEELGFLRSSAFVISCGTCRGKVVTDPCVFDRVLPLPSENWREMAESWCCHGNDVTRTFAGQSLAPSEKDCLVGNLYFLMHPSMLCKDALLLAPRKGKKHVFSISQDKDQTLQLQCRRCRSSLGEAVTGESVCKGKEWHSVHTLKLLKHSICMQPLEGDATLTRSNIFSSYNTESYLAKHLACMSQMNTTFKFILEEESSDQPYLLLWLLSSDTLILTSETSPPGLADIRFHGNRQREPREASRVTNCKLDECCWEAGGEVRTHAVEAHRIVKVLYQALWDEGGKRAHRNWSKDLSVQCMPLPKAMCLELMLLLEASNQHTPASMRHMNGFKVGYLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGP5</accession>
    <name>A0A8B7ZGP5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AP-5 complex subunit zeta-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102411.1">
        <property type="nucleotide sequence ID" value="XM_022246719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGP5"/>
    <dbReference type="GeneID" id="110985590"/>
    <dbReference type="KEGG" id="aplc:110985590"/>
    <dbReference type="CTD" id="9907"/>
    <dbReference type="OMA" id="LMLAYEF"/>
    <dbReference type="OrthoDB" id="744564at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044599">
        <property type="term" value="C:AP-5 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028222">
        <property type="entry name" value="AP5Z1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055450">
        <property type="entry name" value="AP5Z1_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056856">
        <property type="entry name" value="TPR_AP5Z1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056857">
        <property type="entry name" value="TPR_AP5Z1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46488">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46488:SF1">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT ZETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14764">
        <property type="entry name" value="SPG48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25153">
        <property type="entry name" value="TPR_AP5Z1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25154">
        <property type="entry name" value="TPR_AP5Z1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP-5 complex subunit zeta-1 N-terminal TPR" evidence="2">
        <location>
            <begin position="8"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit zeta-1 ARM repeats" evidence="1">
        <location>
            <begin position="326"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="AP-5 complex subunit zeta-1 C-terminal TPR" evidence="3">
        <location>
            <begin position="454"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102411.1"/>
        </source>
    </evidence>
    <sequence length="811" mass="91238" checksum="AD3B0FAE3A71A46D" modified="2022-01-19" version="1">MAAPMMVEKWLKRIRNKTQEELDSLYSSVLQLLNSAQPSERDRSDCLSEVRKLFLYLSCTKYRRRLPEELVDMLKTILTEKNYGISPGAKGHILCSAILQEYAPTEQVVIDSFNPPVDLKQVPFILPVVMSQGQMVGNMDKLVSQMVRWVSTVGFDSEVQARALGCLVTVVTLHRPLLSGEQIYVVSSQISDWLSQASLFQAPNPNTRSKPKKADQVTEIDGTTCQDFFTLLNLSQYYSQDQLLNLHSFSCLRQWLLGTHFSGTTPSSADSSSGKVTPESPVMLLSSGSFATKARQVLVEKACEYCLRVIDQCERKPLKFQDQEMMQACLIEAVSLLDVLCSLNHFLVAKIFPAIKGVYNHLSGENSQPRVLLPLLQFFIHHSEMVVYNPIPAYEHFFGEILSSHYTNPVIAFDTVMFCRDNLQKLCVDTDILEKFFPNLLKILAWNPRTFLMEFVDILPAMISPSTAVEMLHTLLDLPCEVMALEVSQHTSRPGNQTPDNYLIPEPTLRLPPTLEAYRNPEHKPWFNFILRGRSGQGDTISKLGFLHKLLSDTSSYPRVVPVSQAVPVLLRLYFQTVVANADGSLLCQLVPVMMERAGLLFNIPSFTLEVRKVLADELLAMFKQCPALIMDLRTELLDYVATIRNINGKEDFFTHVVWIIGDYSSTAYDSRCNTEVIIKFYEALETLLYEVSSLVQSSSAGSIPYSARLLTVCMTALAKLASRCQDLIPRVLLCLTKVSQQQMKSCTEDEHKKALLDRANELINVLKLPDVAAAILSPSSEITDVHWHEDVNTSIPLLLQATHQIVQHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIJ5</accession>
    <name>A0A8B7ZIJ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110985929</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103091.1">
        <property type="nucleotide sequence ID" value="XM_022247399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIJ5"/>
    <dbReference type="GeneID" id="110985929"/>
    <dbReference type="KEGG" id="aplc:110985929"/>
    <dbReference type="OMA" id="TIHECPR"/>
    <dbReference type="OrthoDB" id="6157510at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022103091.1"/>
        </source>
    </evidence>
    <sequence length="236" mass="25840" checksum="4B6FC120AE22A1C0" modified="2022-01-19" version="1">MAHTNASFNVADGEKGVKLTQDGPPPSYGGQAPNEAPPSYQSIMEKIKEAQANSETPAHFVGKSTNIVRQTACTSLCMGLSYLVPVSMVVMGSVFFDACPVEPMIPIYLIVFGAVYQAKLSIDLNVRGCRHRCQENGEEADDNKCVKFLNWLSRLFGIFLFGFFIAGNVWIFRNWTPSNDPSSASYCYGPLYYYAFWVTISSYIVVGLLMCCMCTCFICACCVCCKAAASSQSGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM71</accession>
    <name>A0A8B7ZM71_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glucose-6-phosphatase</fullName>
            <ecNumber evidence="4 11">3.1.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110987779</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glucose-6-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.9" evidence="4 11"/>
    <dbReference type="RefSeq" id="XP_022106539.1">
        <property type="nucleotide sequence ID" value="XM_022250847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM71"/>
    <dbReference type="GeneID" id="110987779"/>
    <dbReference type="KEGG" id="aplc:110987779"/>
    <dbReference type="OMA" id="ELHINEW"/>
    <dbReference type="OrthoDB" id="6416209at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004346">
        <property type="term" value="F:glucose-6-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016275">
        <property type="entry name" value="Glucose-6-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12591:SF0">
        <property type="entry name" value="FI19814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12591">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000905">
        <property type="entry name" value="Glucose-6-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="15">
        <location>
            <begin position="53"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000905-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000905-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022106539.1"/>
        </source>
    </evidence>
    <sequence length="345" mass="38582" checksum="31771BE24992A920" modified="2022-01-19" version="1">MDRLQALEITHLQKLQHIFGDYSETMLFLSHLGDPRSAFLVYVPLVYCISRGAGLKVLWAAVTSEWLNLALKWLLNGQRPYWWVHECNMYKENNRPIIKQYRLTCETGPGVPSGHAMVTTAVWFIMMSSLTTHLAIAYKPSQRSLMMRFICILPWLFLAGLASVICVSRVFIATHFSHQVLLGVAVGLLVGLVISNLQVESFSTSTHLAFAIFVVMATLIQSGIMVALNFDPTWSMTLALRWCERQEWVHLDTTPLFSIARDFGSLTLLALTEWFITTKEVISGGRKIAALLTSLILAQLIELVKLPTDSVGIFYAMGAVKFGAVMAAMAIVKQLCCYGEKNKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMG8</accession>
    <name>A0A8B7ZMG8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FERM domain-containing protein 5-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106262.1">
        <property type="nucleotide sequence ID" value="XM_022250570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMG8"/>
    <dbReference type="GeneID" id="110987652"/>
    <dbReference type="KEGG" id="aplc:110987652"/>
    <dbReference type="OMA" id="XNEVTKL"/>
    <dbReference type="OrthoDB" id="6266673at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17102">
        <property type="entry name" value="FERM_F1_FRMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000006">
        <property type="entry name" value="FERM domain-containing protein 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000039">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF32">
        <property type="entry name" value="FI22325P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="2">
        <location>
            <begin position="5"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106262.1"/>
        </source>
    </evidence>
    <sequence length="563" mass="64189" checksum="A1313B9E9790CF98" modified="2022-01-19" version="1">MARVFQCTVKVLDDQAEAVVVDFKKDAKGQYLLDEACSRQNLAEKDYFGLRFIDGEKQRHWLDLRKSIVKQLRGTGPPYTVVFRIKYYPTNPEDLKEEITKYQLFLQLKKDLLHGRLSCTSEDAALLGSYIVQSNLRDYDPEEHPPGYASGFQIVPKQTVKVEERIEELHEKHTRGLKPSDAEFAFIKKAFSLETYGIDPHPVRDIYGTSLHIGMNHTGLLVFRANAVVETFKWDDIKKFSYEGRTFFIHALISERRVNHGFRLPTSAATKHLWKSALDLQAFYNPGIQRRRSSILGFRRSSEVTTHTSGGFFRGSRFRFSGRTQREVREKSASLSREEPTFARSPPLIRPRRAQSFKDTALHPPSDITFDGFPQLSGSDHSTPIKVTEPFMTYAPAPPDSTDDSDMHADIEDAIDNVTPIIEEEPIELPIEEETEEAVLSSEQAWPDPDLPSNHVEEVQEAPMPEPKEPRQSGAWTVVKVTLMCTVLVLVITATMLVILYETDHIPTLDPLRRDQSVRDFWEAYYVPVRAWIEGGLEQIGLAYHQLPSIQELKGRVGINTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMT6</accession>
    <name>A0A8B7ZMT6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Glucosylceramidase</fullName>
            <ecNumber evidence="5 10">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987630</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="5 10"/>
    <dbReference type="RefSeq" id="XP_022106205.1">
        <property type="nucleotide sequence ID" value="XM_022250513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMT6"/>
    <dbReference type="GeneID" id="110987630"/>
    <dbReference type="KEGG" id="aplc:110987630"/>
    <dbReference type="OMA" id="NEPLNRG"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006680">
        <property type="term" value="P:glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032006">
        <property type="term" value="P:regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000030">
        <property type="entry name" value="Lysosomal acid glucosylceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033452">
        <property type="entry name" value="GH30_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001139">
        <property type="entry name" value="Glyco_hydro_30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033453">
        <property type="entry name" value="Glyco_hydro_30_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069">
        <property type="entry name" value="GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11069:SF23">
        <property type="entry name" value="LYSOSOMAL ACID GLUCOSYLCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02055">
        <property type="entry name" value="Glyco_hydro_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17189">
        <property type="entry name" value="Glyco_hydro_30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00843">
        <property type="entry name" value="GLHYDRLASE30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 10" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 30 TIM-barrel" evidence="11">
        <location>
            <begin position="112"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 30 beta sandwich" evidence="12">
        <location>
            <begin position="468"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106205.1"/>
        </source>
    </evidence>
    <sequence length="585" mass="66327" checksum="9B06E007AE3B45E5" modified="2022-01-19" version="1">MAGGRKSSFFTVRGKPENLEKNYMYQSSGKNAEDKPCRQKYFQGGSSFVCECSADYCDTVERHGNIQPNEIVEYSSSRDTHRFSKTVLAMNEHPAENVELLTVNSSEEYQRIVGFGGAFTDSATMNILNVSSKVQENLLRSYYSMEGIEYNMGRVPIHSCDFSLSEYSYDDYDGDFDLVNFTLVSEDLDFKIPVIQRAKAMSEYDIRLFASPWSAPAWMKTNGMMHNTFNQGRLIGNPGQKYYKTWANYFIKFLKAYEEHHVPMWGLTVQNEPTAGLVPFYNWQCMAMEPPTMREFIKMDLGPALHDNGYGHIQLMTHDDNLPGILEDTETILNDTQARHYTSGIALHWYQDNLPSADYHQLDEIMQHYPEQFVLATEACDGYQFNAEPVILGSWERGEGYSSDIIMDLNHFVAGWVDWNLALNMQGGPNWAKNEVDSPIIVDADNDVFYKQPMFYHMGHFSKFVPAGSVRIGLHNSNSTSSLDTIAFKRPDGALAAVLLNRGDTDAPFSMHDINKVGYFNSSIPAHTIKTYLWKFADSSLTTESSVSSEHPTVSNDCSRVQNKAAWILTTAWITCSLITMVIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPL6</accession>
    <name>A0A8B7ZPL6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-related protein Rab-7a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110987175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105356.1">
        <property type="nucleotide sequence ID" value="XM_022249664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPL6"/>
    <dbReference type="GeneID" id="110987175"/>
    <dbReference type="KEGG" id="aplc:110987175"/>
    <dbReference type="CTD" id="7879"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090385">
        <property type="term" value="P:phagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022105356.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23176" checksum="B7A5E65B45AC1C3D" modified="2022-01-19" version="1">MSSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTNQNSFKSLDSWRDEFLIQASPRDPENFPFVVLGNKIDMENRQVSTKRAQNWCSSKNSIPYFETSAKESINVEQAFQTIAKNALAQEPETDMYNDFPSQIKLTDENKQDKSCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQJ7</accession>
    <name>A0A8B7ZQJ7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110988172</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107155.1">
        <property type="nucleotide sequence ID" value="XM_022251463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQJ7"/>
    <dbReference type="GeneID" id="110988172"/>
    <dbReference type="KEGG" id="aplc:110988172"/>
    <dbReference type="OMA" id="TERMAKM"/>
    <dbReference type="OrthoDB" id="10043418at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107155.1"/>
        </source>
    </evidence>
    <sequence length="611" mass="71451" checksum="92E48A4F94819A9A" modified="2022-01-19" version="1">MTDEQRKDSNKKSTERMAKMRARKKQTQLAAKMSAASRGRHEEKLTRAQTAKKVAQRKYWKDYKKTWRAELSAERKEEIKAQRREKAREERELLLKIRSQMREDEEKKKIEEQKKKDLEKREREELERMIAEEFNSTEGSRRPAAPRRKAYSRAKASLSKNPIIYAQTVQDLYNKASSKKRQTLQSLPCDPSTAHTLSSNLAKTAVIVSESLKKQLNKLKNAHKELDRRKRRELAATLGCLKKYKLQRLGCRLFGVSPKLAKETTHVPKYTNAATLMQDTKDLVVNYYKQNSVELPDQKTISKKTLQKTRVLEMPIPNLYKQFKNDHPNEKVGKSTFYKLRPKYIKTVGSIKFRGCLCDYCENVKLKLKAVKSKMTLEELSSITLCQKGKDQKYNNKACIERKCQHCGVTKMREHFEGLDTRKEVEWSKWMKVKEEKITKKGKMLLTKKVRQLQHGTTAELLKELEKELHTIPEHLFCKSWQQNQFSKLTSQKLPKGWCVMVLDFAENYACKTQDEVQAAHWTQDQVTVHPIITYYNCNNPTCTKPIMHSIAIISDDLNHDYHAVHAFTSIAIKEVRQRQQELTKVIRFSDGCSAQYKSKGPFYEINFYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRD2</accession>
    <name>A0A8B7ZRD2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">USP6 N-terminal-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987508</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with EPS8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105991.1">
        <property type="nucleotide sequence ID" value="XM_022250299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRD2"/>
    <dbReference type="GeneID" id="110987508"/>
    <dbReference type="KEGG" id="aplc:110987508"/>
    <dbReference type="CTD" id="9712"/>
    <dbReference type="OMA" id="YNDTYEV"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000010">
        <property type="entry name" value="Putative USP6 N-terminal-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000001">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000019">
        <property type="entry name" value="USP6 N-terminal like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF19">
        <property type="entry name" value="USP6 N-TERMINAL-LIKE PROTEIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="104"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="383"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="469"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="617"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022105991.1"/>
        </source>
    </evidence>
    <sequence length="747" mass="84954" checksum="B8BCC8591EFD69A1" modified="2022-01-19" version="1">MSEMQDLAAVERSNRERADIVARYDKGREPGAKIDPWEDASFIIYKVTDKNGFLQEHELPPSPDEEERKLREQEVERTKKWLKMMKDWKRYYPSEKLTRRVYKGIPDKLRGSVWALLLDLKKVKDEQPSVYERMRIRARKLSPDIRQIDLDVNRTFRNHIMFRDRYGIKQQALFHILAAYSMYNTEVGYCQGMSQIAALLLMYLNEEDAFWALHALLTDTKHAMHGFFIPGFPKLIRYQDHHERILKKFLPKVKKNFDKLEIHTSLYSMKWFFQCFLDRVPFSLTLRLWDIYMLEGDKILVAMSFNLMKMHRRMMLKKDMETIVRYLQERLVDDFGFKDDEVIESLQESIADLRRAKMIMPPAPKTSELPQVPFGLARTPSISQATGLRSPMPQMSNGRGKQVTSSSGTPPQTPTASPSTTLSVSNSTSRQTSPEKRTARSEDNYYSSVTSFESQFSSQVAGALTMADPMHEARSPPPCSDRFAQTDEEEGHTPTQKDFLEHEARLRAREGNGRVDKRSLQPSLSSPPGERPQSLPPSSPAMSDPMERRLSLYDNIDVYYNDTYEVDMEESLERLNTPTDQEPFTLGEHETLLYTPVAGNSPARGAVTALARVGATSVQGAGSSPTHMASSSPTRSTGRAGSPYRDTNVPKLSPIKYTPYAGPSYAPPSTSIHPPPPPPRTLPMSELQHFDGEGSPYRVRRATPDREAFGGSVFTTQSTVDGPAVRPKNLHSPVNGVPYFKTQTTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU36</accession>
    <name>A0A8B7ZU36_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110988924</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110988924</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108597.1">
        <property type="nucleotide sequence ID" value="XM_022252905.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988924"/>
    <dbReference type="KEGG" id="aplc:110988924"/>
    <dbReference type="OrthoDB" id="10068766at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="2012"/>
            <end position="2035"/>
        </location>
    </feature>
    <feature type="domain" description="PKD/REJ-like" evidence="7">
        <location>
            <begin position="1218"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2043"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2112"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2074"/>
            <end position="2094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022108597.1"/>
        </source>
    </evidence>
    <sequence length="2153" mass="231166" checksum="4793DD82117146BC" modified="2022-01-19" version="1">MGSDLEEFYDFCVEFVDLPWGEPDAPVCSDGWWATFLFQTEFDFHLDTDEEAGPGIAPQPSSPEEESRTRLFDSVVEILYRQLGGDPYLVCETFGSLLLADTADVWEFGKSMARNIFNSFFSSETLSDKCLRYYRNESSSGISPSGFMVFDESERLISELSGQFRNGSDFCNFILSFEDGQERWSSVVAAAVDGAFNIMNDVSLCNSSLHILLGSDGLATFRNVTGYEQVNAFCAYLRDSFNERINVTDFELQLPANFNITTYKPADGEFLPGVTVQDIVSLAGALFTTNKFNESMILACNRLSPLLNDQVFAGLGHFASLCDAINQGNIHSAVSQCEQLLVPQVYGADYPLALRHVDFGQLLLETILPAFNYVPRFEQDVICPAIETVLNSDTSPQALATIAINGLLRSGIEYGAGICQDIEGVLNYLAPDISWLGDPSDPSYDAVLAQEQLQSRLEYQRFFYGLFDFASTLAGFESYELMCAALIDAVADPGTFDALIDLIRERAFSYLTDENECKIAVEATMSFINLASPETASSNLLYQVTGYYSPQAFCIASAAAFRGETSSEQDTCLGILDCAGVCNGEAANDCAGVCGGSAVRDCASVCNGAATINSCNLCVGGVTGRRQNFGQDRCGTCWSDTDYRITWDCHGTCNGTAFLDACKECVGGETGKPANYNHEHIDCRGVCKGNWMEDDCGFCEPFDESSFVANKYMDCNGDCFTPGATSNRAELNQCNVCYGGNTGLNETSGINECGQCLSDPSADESSCAGCDGVPNSGQVNDACGVCGGTGTTCFGVGWVIPNLVNENSQTQLEVYGAGFEESSSLVCIFEDSEGTQTSSATQYEDYVKLTCNVPSLAAGDYRVKVERDGLISDSIYGDLTVQAEINILTVSPSELTINSSVDTITITATAEEGAFTAVKAASVVPSLIIEGDYNAIVQGSFDDSSDSVMYFSIPMPSSSMRVTFWPSLNGVERLNTPDGAGFEATAYAPAPEFTEAYFASTGAAVLIRFSSGVNFDDFNGCEDVFEDTSKLGSYASCRWVGSRTMFIILGFGDNLLAVGDELVIKTDSIKAFRETYSRYVVGSRSVAGPANPVVPTVVLYGKQRITSCGRIKMSGRQTQGGAGRDMVYSWAVSSQGETSALEAVLSGETGADLVAAGSLMDAETIYTFSLTTQNFLGESDTATMNVSRSALAVPEVTITVKGVDPENVFISDSFDLTAEVTFYSDCVPPGDTVFFWAVDNEDIPLNLKTINRRTLHVDPNTLPGDTTVTFTVAIYKSSDPSNNMTQSFSVQTRYSDLIPIIFGGSELTVGRDSGMLTLDGSGSFDPDQVAVNMEYEWLCSQVTDSTACWSYKEGEAGTQFPSAEAAALSVLSIPASAMQADKTYEFTLVVSKLTRSASISVRVTALNGNPPKVDISTMFDERVLSEDSLSLKANIYHDQPLTSYVWEMVGTDEGYAFLDLSDSNNLDSPASLFPFSNSNGSISFLTIKAGKLTAGSTYQVQLTATTEDGQYGIAKVQFTVVSGVTSCIFSLNSVSSYTELETVVYTVEKCVADESAYPLSYRVFLVSGGRRQTVTSQTNDPAIEGVGKAATEEGSSSNTFAAEVCDAYNSCSFFYHTVSVSVIQECSAAFFAQLLEELVTVEKYKQNYVNAFVNFNEVQSKCANSTDSRRRRRSVSTTDTTTDEASEQLSLVLSSIESSVMDTTSAQLLIDQCNYINTADLAPADKSVFIGVLVDLVAVFQDAGETVPDDSASIVLDKATEIRRSLNATHYANVIATITTLTDSLSQAQLSQLELGAVALETTSSAMTSSVQRAIPNGIFRSKSSGGNAVDFGSALASRFSADWACSTGSCSGVTVSFEHWETGQDEFSLTAADQARVAADITDIKLLDPSSGEELTIANLTERISITLSVTLPQAGKTYECHYWDTVGQAWSNDGLETVLNASSSSEVECLTDHLTAFTLLTVDEPTSDSPTVATDQVTDATTSPPTVHYVTTVDAGPVDVPEDNNSSTTIIIVVVCVVVAVALLVVIGAIVIVKAKKKSKVAASDPNMNGTDAEAPRQPEEAVPARPEQWASQRPTTPRRSPSPQQAPVLQQQQQVQVVTVPVALETAPLHSLPPPASPHLVADMEDTAPPPVYIPPTQSLDITLPITDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUF2</accession>
    <name>A0A8B7ZUF2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Transmembrane protein 85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110988992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108717.1">
        <property type="nucleotide sequence ID" value="XM_022253025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUF2"/>
    <dbReference type="GeneID" id="110988992"/>
    <dbReference type="KEGG" id="aplc:110988992"/>
    <dbReference type="CTD" id="51234"/>
    <dbReference type="OMA" id="QQTFKVI"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022108717.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18512" checksum="043D8BEDE029DC20" modified="2022-01-19" version="1">MGSNIAFLFSRIKMDRQCQAIPDLPAPVGYSERALADVTVHDTESNLAVKKYWDVALGPLKQLPMNLFIMYMSGNSISIFPIMMVGMMVWRPVQALIGIKTTFKMLDPSPQALIQKMVYFVSNLLGIALALYKCSSMGLLPTHSSDWLSFLEPQERMEYSGGGIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUK7</accession>
    <name>A0A8B7ZUK7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110989282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109248.1">
        <property type="nucleotide sequence ID" value="XM_022253556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUK7"/>
    <dbReference type="GeneID" id="110989282"/>
    <dbReference type="KEGG" id="aplc:110989282"/>
    <dbReference type="OMA" id="DLEIMKY"/>
    <dbReference type="OrthoDB" id="10250315at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="509"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="693"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="821"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="854"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109248.1"/>
        </source>
    </evidence>
    <sequence length="1141" mass="123853" checksum="A90A888AAC22A4AC" modified="2022-01-19" version="1">MGNATEVQGLISRNPDLVKYENKQGQTPLHAAAHAGHMETVVALVTSKAQLEKQDKKGYTALASAIFGDEPEIVEYLLESGSKPNASSKMGFTPLHIAAIEGHKKCVEVLLSRLTPSDVDCRDVNGNTPLVIAIAKKYTPIIQLLVEHQGISLDLKDAHQRTPLHIAALCGNKLAGEHILKANPELINVQSQDGFTALHLAAFYGHADTVLTLVTPKNCVKDLRNNRGHTALHLAIINRHYECVKTLVGKGANLNAQDGNGNTGLHLVMMKTSISIENLLEAKLKGKAQTAGDDILQDIFQLLVEHPTVDLSLKNNKDLNCLHYAASWGHKFAVKKIVEAKPSLMNVAQNDGWTALHLAIMNDHTSIVSILVKQELCSKDLKNAKGHTVLHFAVMSDKGDCARILLENGADVNAQDDDGNTSLHLATMTTIIGFRITNEGILQTDKVKESDATRQDMIELLVKDRNANLSLKNNQDFSCLHYASGSGNIYVMNKILEVAPGLINMAKNDGFAPLHLAALNGCTDAVETLVNQGNCVTDLKNVEGQTALHLATSKKNFECVKALINGGANVNAQDKDGDTSLHLVMENLTDKDVKETSGTGTTDEQRIIETLLHHGQIDIGLQNNKGYNCLHYAALNGNRFGVEKILEANPSLIRSTGNDGQTALHIAASNGFADILTALLQKENCGKDIRNASKQTALHLAVDECHLKCIKVLLEYGADVNATDIHESTSLHLAIAKVSMKVSKLSSTKDDGEVDYQFLATIKKYQKVIKLLVERPTVDLTLTDKKGFNCLHSAAINGNSFAVKTMLEAKPSLINTTCTADRGTALHLAVLNNHTDIVAALCEQGCNLNIPNINGQTPLHLAADSCNTKSVEILLNTGANVNAQDKYGDTCLHLLLEKSFKEATGSTAKKQKGVAKSLLVIQNLIRMLLRHGNIDVTLRDNNRDNCLHFAAFSGNDDAVKEILKAKKSVINDRNGSLAPLHIASFYDHADVVQTLAKQGNCNKDLQNSNSQTALHIAIEKNHYKCIEALVNNGANVNAKDNGGNTSLHLVMMKESTQTMLRSASKEELWDVVKKIEQDGSGQDEMTNLVALITSLLKHGANIHLLNNKEQNVPHFAPNSSVQSFLEELFVRFTSTPKQAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUW2</accession>
    <name>A0A8B7ZUW2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fatty acid-binding protein, liver-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110989076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108882.1">
        <property type="nucleotide sequence ID" value="XM_022253190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUW2"/>
    <dbReference type="GeneID" id="110989076"/>
    <dbReference type="KEGG" id="aplc:110989076"/>
    <dbReference type="OMA" id="ECDMKGV"/>
    <dbReference type="OrthoDB" id="412780at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00214">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytosolic fatty-acid binding proteins" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022108882.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15477" checksum="860CDBDD4F5670E2" modified="2022-01-19" version="1">MAQFSGKYKLDNSENFEQFMQALGVNVLLRKVGSTTKPTLTIQTDDGKHFKFITESTFKNITVEFTLGEEYEATSQDGRETKNVVTLNDDKLTQIEKPRDGKGKQVTYIRELTESGDLKVTCILDDIVATRLYKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVA1</accession>
    <name>A0A8B7ZVA1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase TRIM33-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110989163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109017.1">
        <property type="nucleotide sequence ID" value="XM_022253325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVA1"/>
    <dbReference type="GeneID" id="110989163"/>
    <dbReference type="KEGG" id="aplc:110989163"/>
    <dbReference type="OMA" id="MECLCAG"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="103"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="253"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022109017.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="73797" checksum="0EF99FBF53183819" modified="2022-01-19" version="1">MASSSVTAQSVLGKISEGHLECSICCNRFIQPKLLDCLHTFCLACLQTYRDSQDPNSKTLPCPLCRQETMLGENGVTGLQNNFTLRALVEEVSMQEKLLEGQGSEIKCQACDEKDQAVSICMDCAHFLCQECQRAHQRLAVMKSHKIYTLAQLRSGEIIYKSRLRDDIPKCGVHPEQNLSIFCSTCEQLVCTTCSVLSHGNLKHCLVGLDQALDKCKQDVAKAVSEAEKNKARLAAAMVSIDKSREELDAMFNDTLRKISSKAEEKIAKIREEIDRVRQEEEKLRTEGTRIYKEKLKTCDSAKIANTRGVEQTEHKLEEANRVMAQASRYEILDLKQKLLQNLKEASRLQAETVPDKFSHMAFRAGSKSLGTLVLETKDKGASTAEGSTKSRNLGQKENWELVTEIKSYGSKQVKLGGVFDVAVFSNGELIFADNCYKQLISYMPMTKSKDKSLAVAKRWKIKDLLTPRCVAVNRNDQIVVLDGPTVKTFNRKVQLLHQFTVVGGTDSTPTCLAVDEDSLIAVGCETKKEVSLYNPNGTHIKTLKADMIEEYLTTWKKRLIYSSYKKQMLFCIDFSGVKVFAVSITSANEAWGPTGVYAVAKDGSLYIAMHGQPSGEIHRLHSNGQYIGGIIKDCGFPHNITMTPTGDLVVAAAETVKIYHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY36</accession>
    <name>A0A8B7ZY36_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein inscuteable homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110989731</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110007.1">
        <property type="nucleotide sequence ID" value="XM_022254315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY36"/>
    <dbReference type="GeneID" id="110989731"/>
    <dbReference type="KEGG" id="aplc:110989731"/>
    <dbReference type="CTD" id="387755"/>
    <dbReference type="OMA" id="SAITERC"/>
    <dbReference type="OrthoDB" id="5796379at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045179">
        <property type="term" value="C:apical cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045176">
        <property type="term" value="P:apical protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008356">
        <property type="term" value="P:asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009786">
        <property type="term" value="P:regulation of asymmetric cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21966">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.200.10">
        <property type="entry name" value="Inscuteable LGN-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045789">
        <property type="entry name" value="Insc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031938">
        <property type="entry name" value="INSC_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038205">
        <property type="entry name" value="INSC_LBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039921">
        <property type="entry name" value="Inscuteable"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386">
        <property type="entry name" value="INSCUTEABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21386:SF0">
        <property type="entry name" value="PROTEIN INSCUTEABLE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19427">
        <property type="entry name" value="Insc_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16748">
        <property type="entry name" value="INSC_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein inscuteable homologue LGN-binding" evidence="2">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Protein inscuteable homologue C-terminal" evidence="3">
        <location>
            <begin position="85"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Protein inscuteable homologue C-terminal" evidence="3">
        <location>
            <begin position="457"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022110007.1"/>
        </source>
    </evidence>
    <sequence length="557" mass="61017" checksum="8067E28E8A4C2F61" modified="2022-01-19" version="1">MSRIGVVRGMNGFNNSALASWLSDDVIEMHMTDEASVVRWLQDLRTLTECECMCILQGKPIRTSAHNMAKVTSSARDNIYILRQRASSISADFAKLYYKLDSGSWDQVHWLCLSLTIRLRTFLHECTSYVPAMPLHLFQQQQTVFEECGRLVKHAESFEELNGALPPALPTLNVLSSLGKAFNDLVHMVQGILVQTVVRSVRESASEYNIKIAINSIHCLSEDDSEMRRLLAKEGAIQALLLLCQQASLNAVKPMALKAVANLCNVAEGRQELERASGVEYLSEILSSPSATESVKAEAASVVAQITSPNIDNYHHLLGFIEYMEDLLKELTALAETASSSSVFVITVSAIANITFMDSMACDCLASFHTARALVKGCSNGMANTLYCKDQVATILANMAVTDQCRKEIIVSGGTELLVDFLHTRALVPTSSSKKMSPKGSRLSGGSSGSDQQLVMSSSCEKVHQKGAIALARLARDQDSAELILDLEAIPRLVELCCNRRERNDSEPVLVACLAALRKLHSLLGPSVFKSSDVDRLIKPRLIDSFMMCSATKESFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYZ6</accession>
    <name>A0A8B7ZYZ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110644.1">
        <property type="nucleotide sequence ID" value="XM_022254952.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990113"/>
    <dbReference type="KEGG" id="aplc:110990113"/>
    <dbReference type="OMA" id="THHAINH"/>
    <dbReference type="OrthoDB" id="10050996at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022110644.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="12585" checksum="5A39DEFFC3638FDA" modified="2022-01-19" version="1">MSYDDIPLKCQQEFLREAASMGSKFEDIFLKFADTHHAINHARALSPDELKRVDTCIKVFMTSYGESFPECSITPKMHLLENHAVEQLSRFGVGFGLLNEQGGELIHTEXQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A024</accession>
    <name>A0A8B8A024_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulation of nuclear pre-mRNA domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110989934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Associates with the RNA polymerase II complex.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110340.1">
        <property type="nucleotide sequence ID" value="XM_022254648.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989934"/>
    <dbReference type="KEGG" id="aplc:110989934"/>
    <dbReference type="CTD" id="23248"/>
    <dbReference type="OMA" id="RHTPPLH"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16981">
        <property type="entry name" value="CID_RPRD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000020">
        <property type="entry name" value="regulation of nuclear pre-mRNA domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032337">
        <property type="entry name" value="RPRD1A/B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF40">
        <property type="entry name" value="REGULATION OF NUCLEAR PRE-MRNA DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16566">
        <property type="entry name" value="CREPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="811"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="952"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="617"/>
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    </feature>
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            <begin position="732"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="816"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="955"/>
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        </location>
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        <location>
            <begin position="979"/>
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    </feature>
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        <location>
            <begin position="1003"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1073"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1096"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1125"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1168"/>
            <end position="1181"/>
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    </feature>
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        <location>
            <begin position="1192"/>
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        </location>
    </feature>
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        <location>
            <begin position="1325"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1392"/>
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        </location>
    </feature>
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        <location>
            <begin position="1413"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1427"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1493"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1521"/>
            <end position="1536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022110340.1"/>
        </source>
    </evidence>
    <sequence length="1536" mass="165012" checksum="1E485490B12698AA" modified="2022-01-19" version="1">MAGLNVESLKRKFQALNNTQDSIQTLSLWIIHHKNHYRQIIELWMEHLKEAKAPMRLVLFYLANDIIQNSKRKGATVFLDSFAEVLEEAATFSREDAIREKVLRIFKIWGERSIYSVDFCDKLQKATVSQKPAKAKPRPDTKLLVDFNHEEVPQVIEQLARFEGEVELKYRQLNMLNVDVASTETIMQLKDRAGGKRFSQQFEDSAIKLEDYVNSLTKEVELRRKLFDLLQKSEIFYEAQFGEAKIVANAYKNFGMRVASLKKRLEEHKALLPDSFSPIPSPTMDAPSPGATPPRDPNADSIEVEDMELSDEEEDRKRGTIIAAPPVATRRVSRIAALRSKLQATTSSSASISHISTITGAGSRSAFNQPLPSYSPFSSESPSADYSPTEDYPPIPTAGVAPSSTLNSTTATAKKEEGDENYGQIKDRLLQVMHETPKLPSSVNLFDSPKRSESKSSSSIPPVSIPSYTPSPKAFDQQVSPIITVPPAVPAPVPPPGPETDEYDPFASEYPAAAPKPQRQFYTPVNNLPAPPVAPSEEPLSPPDDDMYDPEMVDYLLEMPLEKKKPQASCIIPLAGGFHSPTTKPEVQKEVDSVSYGGSKTTSVPSGKNTSLPSAQSKSSTKSTNSNKPGGTPLRDECSTPPTQEDSPVLKAATSNPIEFLTKIITSSRQSPSSKAPSSSFLSSLSLLTQTVQSAAQKEKSEPFSNDAQGGESADGAASPESQKPPGAPERTNANQQSMKQHNASPSGQADVPFTISALVSSFKEAPNSVHQPTSTAAATNAVPGTVQGQLKNTLAPSTLAGSVTAVSKELHGATAPNSKQNHAGTGSRTSMPFSIGALVSSFQSESKPPPATPVSTPSPVGKSTPFGPSVYQKPSKVPLCQMMNTPGPITPAVSLAVGSTAVSSESLEMLPATSSRDVPSHVTSVDDAGAGQSNSLMARMMHHRTKGQAVFSPPITSNVVPGLQSQPQPPNFQSIILEPPPPPPLPPEEPGVSSESIPPPPPEEHFEKEPARPVPPAGPPTPSGPPPPLSSLPPPPSGPPPPPPPSGPPPAPAPVSQPPPPSTQSSSTGDPHLPPSGPPMSGPLPSGPLLSSLPPSGPALPPSGPPPNFSLEEGHLHLNLPPNSNAPPLHPQGGQPPPPPVPQLTPVRPPQFPGEVPPHQRNPAPLTGPSTPVSSPSPTTRNAVPRMSVRVPPPPPGPPPPNAKRAVSSLSQTSTGHPMPTPRELQPGDTPGEPAVDAPASVHTEQKTPPPVSPVEPVTSEQKQPAEPPQPTSPIPVLGSAEARERSIPVLGQSAKEMWEKPHYPPRSQGVAGRFTEFQACPTEKIDYGHSRPIETLERKRMTYQERFREDKGQSDAFRRSGQPYDSVRDRYSAFPHSNSSRDGGFGRGRRYSDSDRGYRHDYNYNPDRGQDYSQGPPTDFSQGLNRGGQQGPGAGHRQHFNPPGGQEGPPDTSGLYDQSHFRNTKQLIEKELSALTGDLQPRGAPISTLEGRPERERHPTDYGSQRREEAHFWRGPNKRPAPPTWGPPPSHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A189</accession>
    <name>A0A8B8A189_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">M-phase phosphoprotein 8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110990429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022111122.1">
        <property type="nucleotide sequence ID" value="XM_022255430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A189"/>
    <dbReference type="GeneID" id="110990429"/>
    <dbReference type="KEGG" id="aplc:110990429"/>
    <dbReference type="OMA" id="QCFPLRE"/>
    <dbReference type="OrthoDB" id="10071877at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24183:SF1">
        <property type="entry name" value="FIBRONECTIN TYPE 3 AND ANKYRIN REPEAT DOMAINS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="37"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="899"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="933"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="967"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="411"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022111122.1"/>
        </source>
    </evidence>
    <sequence length="1170" mass="129016" checksum="7F0CD23DC532645C" modified="2022-01-19" version="1">MVDDKMAAEERAGENSTPESDETIEEGYDFSESENIYEVEKILGVTKHEGRPLYRVRWQGYGPEEDTWEPRENLLTCEDLVEEFIEKQKLRKQKISQNLAKKYKKSPKKRTPPKESSATAQPKRRRSSEKDASDNETANGQSNRKCSSSDNEGPPPLKDPFWDNLEKGLITFDGDMYSKVKSRRATLDAKRSGQSTESAGKDPDKQQQEWAMSRERTQKVIPKKEEVKDGDAKEEATPDSVGDVKPSLVKDEPFLGEGEMLPEDMYSKVKSRRAYLDAKKLEAAKEEMKQTKKTKKEHRHHRHGHHRHKKSKKDGTRKPKTLIDLEAIGSLETATQKTLSMSPSILERETNAANLFHTPDSCLSVEEVLTVAKLEEKTRNGNYGRQLSGQSVEEDGEGDKIRRVLPLHLETMGSTPSTSQAVPLTPSADSKPIFQGVPLQSTSHLSPQGHSPTFHPTPNFPPVPLAGAGIIPDTPESPDDSQKGPGPSVWKPWEVSSQCSISSGSGSSSSNNNGSVLVSSAELAVPECCTMGAPHPKDSVRDLGQDLADKVSLQAKNVVSPTPKEIPRTTTILCSYNNTAKFSDAPAMASTETAITRDAASMTPLDTLPPANTVKAMDVAPVFGHSKPCSFKMKEPQRTAPVPDKVPAWLELQNFVEKDPIMMGHSAKRSGQEKAAKPPDMALPNVLPLSPCGQPTQGIFLGEHHQGSVTEKNADGKTYPAGQLRRDVTACKASSEKKHHKHHKKAGTKPSLNPTKKDRPSEKSRASHDMKTERPKPTKKKEKSKKTKSKINVGESKKKKTYSVRESASLAKSILQSEPSLPSEIEELLARACPKQGGIQFDFEEDTSTEEPWAKPGLSPIILSNDALKQAVKDGLTERVREALWLNGTHDLEQQDPACGTTLLMQACMYRHDEIAKLLIANGALVNIVQTKTGLTPLMYAADLGFYNTVAILLEAGAHVNLQQATTGETALMKACKKGHAQIINLLLIFGANWAVTTPSANTALEFAILYKHPDIYDIVSNHINRVVMQFESTINQYLCGTAKLTKPVFPLQCFRIRESTEHHIYLNHDFRQYSHNQGCGNVLFIGHAHLGLNGLMCRLTGHSFVYKVTLNGQDLPQLSQGSNFLLSFLPKNGRNLITVKTICDPYTKMLLLVGAYSLQITSDGPQIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A299</accession>
    <name>A0A8B8A299_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110989719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109986.1">
        <property type="nucleotide sequence ID" value="XM_022254294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A299"/>
    <dbReference type="GeneID" id="110989719"/>
    <dbReference type="KEGG" id="aplc:110989719"/>
    <dbReference type="OMA" id="KKPYTPV"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109986.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="15012" checksum="7C8A961A60B61BC1" modified="2022-01-19" version="1">MAAPLALRVVKQFLFLKPVNSFLLAKNSIERRSRDGWHCLRSLPLVTEHLAHLQHRLYSQSPPNSGKPPLKKPYTPVGKHDSPSEKHRDAEKEPLEAFPDDINPVTGERGGPRGPEPTRYGDWERKGRCIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A319</accession>
    <name>A0A8B8A319_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110991169</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110991169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022112079.1">
        <property type="nucleotide sequence ID" value="XM_022256387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A319"/>
    <dbReference type="GeneID" id="110991169"/>
    <dbReference type="KEGG" id="aplc:110991169"/>
    <dbReference type="OrthoDB" id="10409496at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049144">
        <property type="entry name" value="FAM186A_B_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20870">
        <property type="entry name" value="FAM186A-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM186A/B N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022112079.1"/>
        </source>
    </evidence>
    <sequence length="245" mass="28132" checksum="8AF39A779B169505" modified="2022-01-19" version="1">MSSSQDEMTIQDLEDIILEVPEEVISVFEGVVLAKQMRAQEGTIKQLCTIHDRVKAALAHFGVNTNIHATQSEILEEELRRRRPPGFQTKARREEMLHKQNILDTIHEFIQVSIRRETLVDEVGDWLFDVQTTLEKNLLSDEFFKERDKEEIEMERIANAALNDNKKFVRKNVEKLKNLGQEIFEAMNELAQHENLEPGTAGSELKPAFSSLATQRQVAIRAKAKETQEVLNGLFEYVTSKGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A4K6</accession>
    <name>A0A8B8A4K6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Transaldolase</fullName>
            <ecNumber evidence="4 10">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110991049</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="4 10"/>
    <dbReference type="RefSeq" id="XP_022111840.1">
        <property type="nucleotide sequence ID" value="XM_022256148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A4K6"/>
    <dbReference type="GeneID" id="110991049"/>
    <dbReference type="KEGG" id="aplc:110991049"/>
    <dbReference type="OMA" id="IVRFGCE"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000002">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0704">Schiff base</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022111840.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35774" checksum="C4DB490EB2B49F6F" modified="2022-01-19" version="1">MASLLEQLKQFSTVVADTGDFELIDQYKPVDATTNPSLILAAAQIDKYRGLVDDAVAYGKNSASSLEEKITATMEKLFVNFGVEILKIVPGRVSTEVDARLSFDTEAQIATAKRLIALYEEQGIKKERVLIKLSSTWEGIQAARHLEAEDGIHCNLTLLFSFVQAVACAEANVTLISPFVGRIRDWYKANACKADYEPKEDPGVSSVKKIYNYYKKFGYPTVVMGTSIRRIGDIQELAGLDLFTISPSLLEELKATNAPLTRKMSVQLAHASPVEKLSLSEQQFRWLFNENPMAVEKLSDGIRKFAADTIKLENLLKEKLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A5M8</accession>
    <name>A0A8B8A5M8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AP-1 complex-associated regulatory protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110991217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022112220.1">
        <property type="nucleotide sequence ID" value="XM_022256528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A5M8"/>
    <dbReference type="GeneID" id="110991217"/>
    <dbReference type="OrthoDB" id="10069720at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035650">
        <property type="term" value="F:AP-1 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000146">
        <property type="term" value="P:negative regulation of cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900025">
        <property type="term" value="P:negative regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048203">
        <property type="term" value="P:vesicle targeting, trans-Golgi to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031483">
        <property type="entry name" value="AP1AR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34529">
        <property type="entry name" value="AP-1 COMPLEX-ASSOCIATED REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34529:SF1">
        <property type="entry name" value="AP-1 COMPLEX-ASSOCIATED REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15745">
        <property type="entry name" value="AP1AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022112220.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41104" checksum="74C0927490921827" modified="2022-01-19" version="1">MGNCLGTCFGSIRRKSKVNYFGGRYKEYNVGIEFESLIEDDLVQQSERAAITDSERDHLLNKRYSDLVKDQKRRDAEIDSELKKQEENIRLEEEAYIAAKRESARAALQTRAREPRRSRPVANGTAKSSWLGDNESEWNVLWEKTSYEPSHGLRKSELKKKAGADEDDFETFLESVKARSQSVRANGLAHNPYGSIGYATTGFSHPETSDSSPKSREASNEPTESDSDFEPEFVSAETVQVQVPTKDAPNPAEAEQLPHNSRTNVAPQSNLDRVVVEMHNEEKIPGAGRIEETPMDSRNFTQSTAVQSGKESGLDRNPTNQVLDEPNESRTNSAETVQATKPTFKSSATEDDPFDFDRFLEELDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XEU1</accession>
    <name>A0A8B7XEU1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110973088</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110973088</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079260.1">
        <property type="nucleotide sequence ID" value="XM_022223568.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079261.1">
        <property type="nucleotide sequence ID" value="XM_022223569.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079263.1">
        <property type="nucleotide sequence ID" value="XM_022223571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XEU1"/>
    <dbReference type="GeneID" id="110973088"/>
    <dbReference type="KEGG" id="aplc:110973088"/>
    <dbReference type="OMA" id="PQMFPKV"/>
    <dbReference type="OrthoDB" id="10064691at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022079260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079263.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34779" checksum="5DF34472EE2BE76B" modified="2022-01-19" version="1">MLRSKPLPPIQPPTTRKPSVKCVSFPDWDPKSSRLDDEQGRGQALAVTCQSGTRHKMDNPRPPMNRPVFLKQRSPLVTTKSRPEDGVAALSAALSARYPLVRGSSTNDFKRSRTLYTTNATLVNRKKPSDSREGRPDNHKRQSYRRRKDPPVLLTRGSHHSFPPGKVIKRNDDNIVIPQMFPKVRRVDRGGPCPTQLYTQTKLSYSGKINGSVQLDHYVQRNSRPRIEPLQAPSTSAGASGGEDSLESVISSSRIMLEDRGPDRLDREWPGRGLSPLFRPYHYFDDEPSVPPNSEIGPSRMQMMTPNEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XFG7</accession>
    <name>A0A8B7XFG7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="8">MAD homolog</shortName>
            <shortName evidence="8">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110973188</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079498.1">
        <property type="nucleotide sequence ID" value="XM_022223806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XFG7"/>
    <dbReference type="GeneID" id="110973188"/>
    <dbReference type="KEGG" id="aplc:110973188"/>
    <dbReference type="OrthoDB" id="5794312at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10497">
        <property type="entry name" value="MH2_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF61">
        <property type="entry name" value="PROTEIN MOTHERS AGAINST DPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="10">
        <location>
            <begin position="52"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="11">
        <location>
            <begin position="297"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022079498.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="54922" checksum="4063D118DD696214" modified="2022-01-19" version="1">MSFTQFCQSPWSRWATFEPPLQTQRHIAQLGCHLLGQSSNMSMASLFSFTSPVVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMEDLEKALSRPGEVSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKALDICEYAFGKKQKEVCINPYHYKRVESPVLPPVLVPRHSESVPSHSLLPYRSLPDPPYPHNATYPQSFQQQANQGLSPHHPGSPGGQLSPASSSPSSPYGVPADTPPPAYMSSDDGNTNDGTPMDTSSAQPTKSNMNMQDVQPVTYTEPQCWCSVAYYELNNRVGEPFHASSTSVIVDGFTDPSNKTDRFCLGLLSNVNRNSTIENTRRHISKGVHLYYVGGEVYAECLSDSSIFVQSRNCNYRHGFHPTTVCKIPPGCSLKIFNNQEFAALLSQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLNGPLQWLDKVLTQMGSPHNAISSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGR3</accession>
    <name>A0A8B7XGR3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sex-determining protein fem-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110973434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079969.1">
        <property type="nucleotide sequence ID" value="XM_022224277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGR3"/>
    <dbReference type="GeneID" id="110973434"/>
    <dbReference type="KEGG" id="aplc:110973434"/>
    <dbReference type="OMA" id="NPHVWDI"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022079969.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="29247" checksum="86AB8A665ABE0A41" modified="2022-01-19" version="1">CFKAIEWLRTAAESFLERNQIPLESFGFLALAVFVAVTFIWCISNGCKHASGVESPRSTKVVSIFELAKTVHHPGHAGQVKALVSKLQFDVNFPIPQSGMTLFLYACISGHKDLVNFLLERGGDVSVANNDGDTCLYLATFACAGSPSQDLSILELLISAGCDVNAQNHKGNTALHWAASKGDINIIKLLLINGANPNIRNSIGMYPISMATNAGYLKAGKLLKISLPDPSTPRDMFEPHTPLSVRLGLLSPRKDHLALSPRPKKRINLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGX1</accession>
    <name>A0A8B7XGX1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Transferase CAF17, mitochondrial isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9 10 11 12" type="primary">LOC110973055</name>
    </gene>
    <organism evidence="6 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022079191.1">
        <property type="nucleotide sequence ID" value="XM_022223499.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079192.1">
        <property type="nucleotide sequence ID" value="XM_022223500.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079194.1">
        <property type="nucleotide sequence ID" value="XM_022223502.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079195.1">
        <property type="nucleotide sequence ID" value="XM_022223503.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079196.1">
        <property type="nucleotide sequence ID" value="XM_022223504.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079197.1">
        <property type="nucleotide sequence ID" value="XM_022223505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGX1"/>
    <dbReference type="GeneID" id="110973055"/>
    <dbReference type="KEGG" id="aplc:110973055"/>
    <dbReference type="OMA" id="MDRLHGV"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="4">
        <location>
            <begin position="79"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="CAF17 C-terminal" evidence="5">
        <location>
            <begin position="298"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022079191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022079192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022079194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022079195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022079196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022079197.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="42276" checksum="752D5B028DC96E0D" modified="2022-01-19" version="1">MAAPSLARNVNTFLLRASACSMQSIPFTKRLQLPLAMKQTLCKPGLGPHRGVSTGHVSHSRAATSGWGVRCVKLEGRGLVRVVGPDATELLQGLVTNDTGVMWGANRAMYAMFLNTQGRILFDVMCYRVSDDASKEPSFLLECDAEVQDKLVKHLKMYRVRKKAEVSSADEQLQTWAVFSKDDGDMSPLAIPKMQATNCGRCPTDVKDPRVEGFGRRAILPREEALTHLIPDSTEADPEEYTLHRYRWGVPEGVMDLPQGEALPLESNLAYMNGVSFSKGCYLGQELTARTHHTGVTRKRIMPIQILSHGRSPPEVGAKIISEAGKNLGKLRGYLGNSGLALLRVAQCQDKKLLVIGEDGSRTELSASIPSWWPQEQEELRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHE1</accession>
    <name>A0A8B7XHE1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Noggin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110973603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the noggin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080213.1">
        <property type="nucleotide sequence ID" value="XM_022224521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHE1"/>
    <dbReference type="GeneID" id="110973603"/>
    <dbReference type="KEGG" id="aplc:110973603"/>
    <dbReference type="OMA" id="YDPFWMS"/>
    <dbReference type="OrthoDB" id="5950649at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.520">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008717">
        <property type="entry name" value="Noggin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10494">
        <property type="entry name" value="BONE MORPHOGENETIC PROTEIN INHIBITOR, NOGGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10494:SF6">
        <property type="entry name" value="NOGGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05806">
        <property type="entry name" value="Noggin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008129">
        <property type="entry name" value="Noggin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034249059" evidence="7">
        <location>
            <begin position="16"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="166"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR008129-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022080213.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="26015" checksum="8C7635F1EDB106B9" modified="2022-01-19" version="1">MIVLLTLCSVVGVVSVTVGTSNRSPSLLLSRPLIVSDRTQPLPLPREIVDGITVNLPRPKDLNPNKLQRRLQSEFDPQWMSVDAPSPDDGSEVELNPVHSETPAWLLNELRNLNLSHVPNNVAGLSATTISALEVWLLERASCPVRYEWVDIGPLFWPPWVKHGTCVARQCSWPSGMSCVPGETNTITLLRWHCRSASLEEDDRSSKKRNKCRWLKVPYPIISECVCTCDQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XI17</accession>
    <name>A0A8B7XI17_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973721</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080439.1">
        <property type="nucleotide sequence ID" value="XM_022224747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XI17"/>
    <dbReference type="GeneID" id="110973721"/>
    <dbReference type="KEGG" id="aplc:110973721"/>
    <dbReference type="OMA" id="CCAPRYF"/>
    <dbReference type="OrthoDB" id="9942506at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034853399" evidence="1">
        <location>
            <begin position="17"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080439.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27421" checksum="9A48212EEE8373B9" modified="2022-01-19" version="1">MWSGLLVCMLVVGAMAFQPSVPFGASQPGERHEPCCAPRYFTFNQVTTTTSVQDGSLLVEYDNAEGAYDAKFERIAVKLVIDYFNGTEVYLRLIEDYIKGVSYYILEHAGEDICFVGRTEGRFNEECLNDDAQFLSEATLGDYDLVLDNWYVVSEDKTEHSVKSVQHEGCVPVGLLTRTFDPDTGKELKVDDSRVLDFKLGICDPDKYFKPPASCDEGRAVDKPTPQMLKYRRKGLFRRSISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XII0</accession>
    <name>A0A8B7XII0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110973474</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110973474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080011.1">
        <property type="nucleotide sequence ID" value="XM_022224319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XII0"/>
    <dbReference type="GeneID" id="110973474"/>
    <dbReference type="KEGG" id="aplc:110973474"/>
    <dbReference type="OMA" id="ANHREAN"/>
    <dbReference type="OrthoDB" id="9901374at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin C-terminal" evidence="4">
        <location>
            <begin position="951"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="595"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="857"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="905"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="965"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022080011.1"/>
        </source>
    </evidence>
    <sequence length="1001" mass="109322" checksum="E9F25370FCED879A" modified="2022-01-19" version="1">MATSTMRDDNYRKDKDTMSQSKGNTSFELIKEKMKEKRRKKALNDGNTSWSRSFSKKKGTSASFVLKASLRSNNQSLAKALAASRHEAQQAHHSVLELQRERQYLLQQANSTRQAEKECMQRFGNIKQVLTKVTHSLLDAVSSLGQALDLCSSLPLRDSSLGILPRASMTSDDDSFGIAQKASQGLSTYSRQTRLVSKAIESAASNIMDASKTMATATIHQSESPSRNSQSKPAPGSSRSEGPTKVSQSESTVNTVDQSEPVLEGVGQSKEMKDLADEEFELDFPSLDDADFHLMFTEETPDNQGVGSCDSRHQSHCLEAPVKRSRTATVLDPIAIKKALADDGDNATHTKDPGEDATTILSPHPEPPFQQPPGEKTQASSPLTHQKKHLIKSPDKRPAITSRRMTYNVTLDNSDSASNKTFEVQASPFIPLVPNQQAGAVKERYVFVHSPPCNASKYKSLDTEPRDATSHSVPTQDEHSISQADKTRFNHDEQVIRPWGNIQVDKPCSSSSAIKPKLKSKPSANTSRSLLPKPPKKETSKDPAKICQTKHTKTGLKKLSKKTALMSESFRNDLAIFDLSAGDSFSLAPPVLKRVKPKPTSSLAEFSKTNNDQDGAPCLKKEKPTEVHSPHDGKQGPPADLVVPGKALEPVHQEELLNPMPQREESHLAYNKHIKQAEPTKPTEAVNSERGGKIKRKSKKAKSVVSPTISKMAATSNWKTELNLAAVKSESKASDIFDGICLGEPSRQTGKAKLAPSWKPAEDVDDAILSVASAQPTKHHPTKRVKAKALHVPQTEGIIDRADTASTMLDNVGKYSTLHRGKTSTNKAKPSVTFEQTDPVQANHREANEFLFDISAPHGLQKTPPSKKSASPHLRSPSPSTVAEPIAPSKVGSDSERGPSVVAMETNSQTVTNNSHPHQAQQGRKRTADALVGVQLASERGEEESEAQETGRRSRRAVPISYKEPSLRDKLRRDHSPTKKKTKTKKVKSKPTALATVTNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIV4</accession>
    <name>A0A8B7XIV4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Testis-expressed protein 36-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080729.1">
        <property type="nucleotide sequence ID" value="XM_022225037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIV4"/>
    <dbReference type="GeneID" id="110973863"/>
    <dbReference type="KEGG" id="aplc:110973863"/>
    <dbReference type="CTD" id="387718"/>
    <dbReference type="OMA" id="SWFPHIG"/>
    <dbReference type="OrthoDB" id="10003408at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029369">
        <property type="entry name" value="HDNR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35440">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35440:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15115">
        <property type="entry name" value="HDNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function with conserved HDNR motif" evidence="2">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080729.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23261" checksum="C00A07569EEEBD41" modified="2022-01-19" version="1">MPKSRACVPSASNDGIWFRTRGWSDPPMMRDTMTSTGSMLSTSLREQQPERPKPPPEPFNTKIELSYTVNNPFSMHDNRNSFQDHGVYFGHGLGKRLFHGDERQHGSKDFYTWDLPEQDLLSTNYRDAFPGRPCRQPPTRRRFPRQHSEPKHGQQKLDTTTTDWFRSPDVPYKTETQTLVSSQEPHLKPNPWKYSYKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJJ1</accession>
    <name>A0A8B7XJJ1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocon-associated protein subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Signal sequence receptor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110973642</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAP-alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080307.1">
        <property type="nucleotide sequence ID" value="XM_022224615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJJ1"/>
    <dbReference type="GeneID" id="110973642"/>
    <dbReference type="KEGG" id="aplc:110973642"/>
    <dbReference type="CTD" id="6745"/>
    <dbReference type="OMA" id="TFPYSFT"/>
    <dbReference type="OrthoDB" id="1926781at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005595">
        <property type="entry name" value="TRAP_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924:SF0">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12924">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03896">
        <property type="entry name" value="TRAP_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034505346" description="Translocon-associated protein subunit alpha" evidence="14">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="33"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022080307.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34673" checksum="DEB8E8550CFC14C2" modified="2022-01-19" version="1">MFKIVPKFILLLMLVLPASVLLSNRASLVADAEEDTVEDVLEGEEIEDEEEDEEDDEDGQIETEEEGGGGAGEEKTAAAKTGEEEAEEEDEQEQLKAAEDVETTLLFTKNADKEIPVNKLIQILVGFTNNGKQNYMVENIHASLRYPQDFSYYIQNFTSREYNTLIEPGKEATLEYIFQASESLALRPFGFVMELHYKDAEGNPFMDAVFNDTVQFIEQDEGLDTETFFLYVFLVALVVLLVVGAQQLVVSLGKKRKVAKPVVETGTQNHTDIDYDWIPKENIAVKKSPSPRKSPRRRTAKRATGSGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLI8</accession>
    <name>A0A8B7XLI8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110974027</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081022.1">
        <property type="nucleotide sequence ID" value="XM_022225330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLI8"/>
    <dbReference type="GeneID" id="110974027"/>
    <dbReference type="KEGG" id="aplc:110974027"/>
    <dbReference type="CTD" id="6529"/>
    <dbReference type="OMA" id="FNNINHR"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:symporter activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="SLC6sbd-TauT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
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        <property type="entry name" value="SNS_sf"/>
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    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF265">
        <property type="entry name" value="TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="127"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="175"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="234"/>
            <end position="255"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="294"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="331"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="364"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="551"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="47"/>
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    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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        <location>
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        <ligand>
            <name>Na(+)</name>
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        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
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    <evidence type="ECO:0000256" key="7">
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    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="RuleBase" id="RU003732"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081022.1"/>
        </source>
    </evidence>
    <sequence length="640" mass="71866" checksum="068E4D52647EF9D9" modified="2022-01-19" version="1">MSVVADPHQNSLGRSGQDRGESVPLKDKDGNCNAVDHVLGDGKEPGTRDALEEVQEAEAPDPPGGKRETWSHNVDFVFACIGYAIGLGNVWRFPYLCYKNGGGAFLLPYAIALLIAGIPVFFFEVAIGQFLSLGGLSIWKICPLFKGVGYAGLVMSFWLNVWYVMPMAWALLYLVNSFTTSLPWEDCDNTWNSDNCVANYSVSDNVSTTPTDEFWNLYVLEKTEKIEESGSIRWQLALTLLVVWITCYFCIWKGVKWTGKVVYFTSMYPYVMLIVLFFRGVTLEGAVDGIIYYLKPNFARLGDSEVWLDAVTQIFFSYGTGLGSLIALGSYNTFKNNVYKDALIVSCINSGTSFFAGFVIFSTLGHMAHVQHVDVANVTASGPGLAFRTYPAALAQLPISPLWSCFFFSMIFMVGLDSQFCTMEGFFTAAMDEWPKYLRRYKEIFIGITCVISYFIGLSMVTQGGIFVFEIFNNYAASGISLLFLMFFQTTAVSWFYGVDRFYRNIEQMIGYKPFIWWKICWVGLVPLLCFGVFIFNLIQFKPLTLDNYEYPPWAIAFGILLALSSMLCIPGYMLYLLVVTPGSIRERFTKCITPNWSEEDYRKGIPLPRDANQKIQGPYQDYLPPSYATAVAEGGPTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM83</accession>
    <name>A0A8B7XM83_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GlcNAc 2-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">N-acetyl-D-glucosamine 2-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Renin-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110974162</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an N-acyl-D-glucosamine = an N-acyl-D-mannosamine</text>
            <dbReference type="Rhea" id="RHEA:19033"/>
            <dbReference type="ChEBI" id="CHEBI:16062"/>
            <dbReference type="ChEBI" id="CHEBI:17274"/>
            <dbReference type="EC" id="5.1.3.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19034"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:19035"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Forms a heterodimer with renin and inhibits its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the N-acylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.8" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022081272.1">
        <property type="nucleotide sequence ID" value="XM_022225580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM83"/>
    <dbReference type="GeneID" id="110974162"/>
    <dbReference type="KEGG" id="aplc:110974162"/>
    <dbReference type="CTD" id="5973"/>
    <dbReference type="OMA" id="DDLKYCW"/>
    <dbReference type="OrthoDB" id="414129at2759"/>
    <dbReference type="UniPathway" id="UPA00629"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050121">
        <property type="term" value="F:N-acylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00249">
        <property type="entry name" value="AGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000021">
        <property type="entry name" value="N-acylglucosamine 2-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010819">
        <property type="entry name" value="AGE/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034116">
        <property type="entry name" value="AGE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007588">
        <property type="entry name" value="Znf_FLYWCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15108">
        <property type="entry name" value="N-ACYLGLUCOSAMINE-2-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04500">
        <property type="entry name" value="FLYWCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07221">
        <property type="entry name" value="GlcNAc_2-epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLYWCH-type" evidence="15">
        <location>
            <begin position="200"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022081272.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="82788" checksum="A240C3B5733B7996" modified="2022-01-19" version="1">MKLDAMEITNREGRTDIFGINPPRMPLGYIVETYPAPQPVGFPTAMPGPVLENNTFIPGENLPSTVGVKRPALEGISPIDLSTPAASTAHSLDGDSPSHDRDHHSNPVDSAEAGQLQDSVIMQCEEIPDDENESVLDNTSPFQESVEVLSDSSFESEGVSASESYRDEEKTAGEGAAVAAQDETLVPYSEVFTQRSIAYVIGGYAYTKNRQQLGKTYLRCRQRGCSARAMIMNNVQQATVFNNIHNHPPPDISKKARRRVYSVPPPYDTLSDGRGRAGSVSSPQLLPVERELPSGIVWQSPLGAVVPSGLQYQRSMDDGVSTVPRIVYVHSLQSSKMASTAKARLPEFLEKMERELDRVMEFWLKHSHDNLNGGFFVCLGRDGRRYDDLKYCWLQGRQVWMYSKLYNTVAKYHTPEVLEAAKKGGLFLMNYVKNPATGKCYFAVTKDGKAVKIQRTIFSECFYMLAMSELARATKDDMYKQEAIKMLDQLQHWVCVDDTGLGRPQLLGAPRVNSLSRGMIFLNLLDELTAGDPALQEKYASLEKWSIEQSLQHMQRDGTVILETVSTDGKELPGSAGRLMNPGHAIETGWFLLQCSMKHDLPELRRLAADNFIAKPFQTGWDLEHGGLYSFLDADGLSPTQLEWNMKLWWPHCEALIASLMAYQQTKEERFLEMFEKVFDYTFSRFVDVEHGEWFGYLNQEGKVTHDFKGGPFKGCFHVPRCLFMCTQMLRKLLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ73</accession>
    <name>A0A8B7XQ73_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Ras-related protein Rab-2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110974770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endomembrane system</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082327.1">
        <property type="nucleotide sequence ID" value="XM_022226635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ73"/>
    <dbReference type="GeneID" id="110974770"/>
    <dbReference type="KEGG" id="aplc:110974770"/>
    <dbReference type="CTD" id="5862"/>
    <dbReference type="OMA" id="FNHLTCW"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01866">
        <property type="entry name" value="Rab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000275">
        <property type="entry name" value="Putative ras-related protein Rab-2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="182"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022082327.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23560" checksum="E9F6954E21DA7E8F" modified="2022-01-19" version="1">MSYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMINIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSSSNMVIMLIGNKSDLEARRDVKKEEGEAFAREHGLIFMETSAKTAANVEEAFINTAKEIYQKIQEGVFDINNEANGIKLGPQHSPTNPTLPSQGGGQQSGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRG9</accession>
    <name>A0A8B7XRG9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110975024</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082787.1">
        <property type="nucleotide sequence ID" value="XM_022227095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRG9"/>
    <dbReference type="GeneID" id="110975024"/>
    <dbReference type="KEGG" id="aplc:110975024"/>
    <dbReference type="OrthoDB" id="10053431at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13286">
        <property type="entry name" value="PH_OPR5_ORP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000002">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000030">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000020">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="207"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="364"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="810"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="840"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022082787.1"/>
        </source>
    </evidence>
    <sequence length="965" mass="108515" checksum="716CADC17C55714D" modified="2022-01-19" version="1">MAAEDPHDLPQKLQSFSPSWGRRLRSASSPASPEGATARSSFAEAVWPADVKPKSLLPINRSPVLTRKKRSISSPPVPVDPDQTSVSLNAKSMNLAPIQESTDKEATEMQYSNDSSPNYSPVPGQGTDQDHGEIFEKDSLRPSSKFQAPRSRSEGKLNTSGDGYGSSGTTPSKLSKRESLKAQKKNYRREKKRVTKELLSALKDPSIIVMADHLKVRGTLKGWTKLWCVLKPGLLIIYKSPKHGQWVGTILLNNCELIERPSRKDGFCFKIYHPLDQSIWATRGPKGETMGSITQPLPSQYLIFRAPSEAAGKCWMDALELALRCSSLLMRSMRDGTALDPATISQSFSKEKGLNESEIENTHFKHEGLDDESPDNESDKDQESKSESDMSEPEDITSIDGTIPAHNETTYVVNKVEELGQECSQTETLEEENKGLIWSLVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDFYYHADLLSQAILEDDPLSRMKQTARWYLSGFYKKPKGLKKPYNPIIGEIFRCLWTHPKTKSRTFYIAEQVSHHPPVSAFYITNRKDGFCISGSILAKSKFYGNSVTAAMDGLATLSFLTRGEDYHITMPYANCKGILYGTLTMEYGGKVVIECDKTGYKTEFEFKLKPFLGGSDSSNQVVGKIKFGKETLASLEGHWDDKVYIKDKRTGNMELFWVVSPDVRAARLHRSTVTMEEQAENESERLWSRVTEALGKSEIQEATNEKFVLEDEQRKGHKERKMKMVEWEPHLFERDEITRDWVYKHMDNRPWDPLNDIEQFEHKGIIQTRTRHKTSILRTTSIISLPHKNGPHEQRLKRNASLQHKKRQAGSRVAASAVAAGRPRGASGSADSEGSTPPEKDSEEELSEAELTAEKVEAASTSLQGTVIMEQAIQPMVEGQRRIEEQLKAINSRLAVMIRQTRREEEESAPISRELIIIAAVLLVGQLIIAFLFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XT38</accession>
    <name>A0A8B7XT38_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Prolyl endopeptidase</fullName>
            <ecNumber evidence="10">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110975303</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022083372.1">
        <property type="nucleotide sequence ID" value="XM_022227680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XT38"/>
    <dbReference type="GeneID" id="110975303"/>
    <dbReference type="KEGG" id="aplc:110975303"/>
    <dbReference type="CTD" id="5550"/>
    <dbReference type="OMA" id="LDPWFSH"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000001">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000275">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="13">
        <location>
            <begin position="31"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="12">
        <location>
            <begin position="506"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022083372.1"/>
        </source>
    </evidence>
    <sequence length="734" mass="83543" checksum="B5B5EED11B4670C8" modified="2022-01-19" version="1">MPSTSRPVFPSLVFMLSVFFHFTAFKMIKYPEVRRDETVVDDYHGTKVPDPYAWLEDPDSEATKAFVDAQNDLTMPFLEKCTTRKPFHDRLKELWDFPKYGCPFKRGSRYFYFMNTGLQNQNVMYVQDTLEAEPRVFLDPNTFSEDGTVALRGHSFSEDGAYLAYGLSTGGSDWVTIKFMDVAKAEPLPDMLERVKFSCMDWTHDGKGFFYNYYEKQEGKADGTETTSNVNQKLRYHVLGTAQSEDVLCAEFPENPKWLSGAEVSDDGRYVILSIRQGCDPVNRLYYCDLEKTKHKITGILPWVKLIDNFDAEYEYITNEGTLFTFKTNLKSPKYKLINIDFAQPAMENWTDLVPESDTDVLEWTACVCKDKLVLCYVHDVKNVLHLHSLSTGGRLTTFPLDVGTVTGYSGRKKDTQIFYQFTSFLTPGVIYRCELDKDTVQPKTFREIEVKGFDPSLYQTKQVFYDSKDSTKIPMFIVHRKGIEMTGDHPVLLYGYGGFNISIMPSFSVSRLVFIRHLGGILAIPNIRGGGEYGETWHKAGMLANKQNVFDDFQCAAEYLIKNKYTSAKRIAMNGGSNGGLLVAACANQRPDLFGCIINQVGVMDMLKFHKFTIGHAWTTDYGCADKKEEFEWLIKYSPLHNIKPPADPKIQYPSTMLLTGDHDDRVVPLHSLKYIATLQHALGNTEQQTNPLFVRVDTKSGHGFGKPTAKVIEEYSDIYAFIAETLGISWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTL1</accession>
    <name>A0A8B7XTL1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein C10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110975744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0456 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084189.1">
        <property type="nucleotide sequence ID" value="XM_022228497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTL1"/>
    <dbReference type="GeneID" id="110975744"/>
    <dbReference type="KEGG" id="aplc:110975744"/>
    <dbReference type="CTD" id="113246"/>
    <dbReference type="OMA" id="GNDMMKM"/>
    <dbReference type="OrthoDB" id="75738at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026317">
        <property type="entry name" value="P_C10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13463">
        <property type="entry name" value="PROTEIN C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13463:SF3">
        <property type="entry name" value="PROTEIN C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14974">
        <property type="entry name" value="P_C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022084189.1"/>
        </source>
    </evidence>
    <sequence length="124" mass="13562" checksum="DD43B287326BBDFA" modified="2022-01-19" version="1">MAQDTQSRLSLEDAKAVLQKVLEAFLTPENKTRMEEVKDAAGNDMMKMMQVVFPVATQIQMEVIQKYGFSADGEGAVKFAQLIRHYETMDSTVADLSAQLKAIFLPPLPPPVPTQSQASVASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTT5</accession>
    <name>A0A8B7XTT5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amine oxidase</fullName>
            <ecNumber evidence="7">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13" type="primary">LOC110975787</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022084262.1">
        <property type="nucleotide sequence ID" value="XM_022228570.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084263.1">
        <property type="nucleotide sequence ID" value="XM_022228571.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084264.1">
        <property type="nucleotide sequence ID" value="XM_022228572.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084265.1">
        <property type="nucleotide sequence ID" value="XM_022228573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTT5"/>
    <dbReference type="GeneID" id="110975787"/>
    <dbReference type="KEGG" id="aplc:110975787"/>
    <dbReference type="OMA" id="EQARGMW"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022084262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022084263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022084264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022084265.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="51762" checksum="61AE9E4269CF22E9" modified="2022-01-19" version="1">MYKSLPSVMATNGVPPSGEGHDVIVVGAGLSGLTSAYAILQKKPTARLMVIEASDHIGGDISSKTLKSSTGANDWDICGSRIGTAQKEVLKLLADLGMETHPQYNKGNKFWRLPDGKLKKFSGAIPPLPYTTLLDVVRYFKKVDSMQSQVNTERVKECKHAEEWDAMTVDDFLKKYLWTHVGKITLETMTRSFCSSSPSELTMMQYLYIIHTCGGWDLHINSGDKGRSDLIIKGGAMSLCHKLVEKVGKQNILFGDGVSGIAEQGGGIKVTTQSGKEYHSQRVIMAIPCCLTGKVTYDPPLPLDRSHTFPSSNFLMVSVITYKTPFWREAGHTGEYLNMAASNPTSTADTDNTLVISFDMTLPGGQPALKAFSSAARLKGKSREEKKDTILHLLSNIFGPQVLDCLDYTDREWAGDVVTDEDKAPATKSSELLASITKPHGRVHWAGSHTGTSWCGTLNGAVQAGQRAAEEVVATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUE6</accession>
    <name>A0A8B7XUE6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GRIP and coiled-coil domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110975585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022083862.1">
        <property type="nucleotide sequence ID" value="XM_022228170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUE6"/>
    <dbReference type="GeneID" id="110975585"/>
    <dbReference type="KEGG" id="aplc:110975585"/>
    <dbReference type="CTD" id="79571"/>
    <dbReference type="OMA" id="AEMQAIN"/>
    <dbReference type="OrthoDB" id="9898580at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.60">
        <property type="entry name" value="GRIP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="8">
        <location>
            <begin position="674"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="110"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="290"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="427"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="628"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022083862.1"/>
        </source>
    </evidence>
    <sequence length="735" mass="84603" checksum="D05E3EE22E608060" modified="2022-01-19" version="1">MDRGTRKDLLETIEKQKEQLSRYESRLRDIVHAYKNLSKEKEALEASVQALSATSPQRPLSTTQSIKPQGQRSDQEDAGKDEQNESADTATGKEDASDSESTETEGNANYHQLKEQLSTLTAALATVTAQKSKMEASFQADKKKLRQEFEETLKQHQEGKEQFEKARDLLQEQLSEARTKSRLQQQEREQEHVDHAVMIRELQGLLAQERNDKERLETKLVDLEDGLAIAKSQPDKTAAYEEHVKNLNRDLDAVRSQLRAAEQKASRPSPLLVQLQKEMAEMKAQHRIQVEVEQQKAKESKEVLKQLREAEEERVATLESKLAELSEVVGNYDRVKQQGQQAVMRLKERITQLDLENTALAKAVNKAQTSQSEEIVNPDATVSELTEKIMKLKGLLKLASQKSEKPVDIDDLCNIEDHTSLEIHPDHRSCQQELKQLKDEFERYKLRAQGVLKNKSVKDTSSNKEIEALQSQITEMRDRISVLRQQLDDEEANHKQTVTNYEDKIFTLKEQHRSALSQAESEYKQRAADMEQQIHRQRDRTMALLAEKAQEIDMLRQQVHNRYGGPATMQGDFSLRRQSSGDVFQESDEQPKSEADETVSQLQVSMVQSNNPSLLHFAEERARREVELASIKKQKQQLEGALRQLQEKHAMAAQMHEEELDQLREEAERWKRNRSREGTNLEYLKNVVLCYFQTESHSKRQQMFNAIATILQFTRKEKEGVLKKQGASWWGYGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUP9</accession>
    <name>A0A8B7XUP9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Collagen triple helix repeat-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084583.1">
        <property type="nucleotide sequence ID" value="XM_022228891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUP9"/>
    <dbReference type="GeneID" id="110975992"/>
    <dbReference type="KEGG" id="aplc:110975992"/>
    <dbReference type="OMA" id="PCQGAER"/>
    <dbReference type="OrthoDB" id="5985978at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057873">
        <property type="entry name" value="CTHRC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25815">
        <property type="entry name" value="CTHRC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034309924" evidence="2">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CTHRC1 C-terminal" evidence="3">
        <location>
            <begin position="61"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084583.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21520" checksum="B28270A7F67D22AB" modified="2022-01-19" version="1">MATAGSAALLGLLLFLAVALDLPSANSWGSTCDQGSPGPPGPPGPPGSSGESGAPEFLDYNNWRQCAWHSANGNDYDGNIYTCTIQKRYSNSALYVAYGGNLRLYGCDGCCKRWYFTFNNNECSPVPIDGVVYQHNTYHMNLHRHRNIEGYCHTLGAGQIDVRFAVGDCHGHGNADAYTGWNSASRIIVKEIPASPYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUU9</accession>
    <name>A0A8B7XUU9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyltransferase-like protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110975460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083676.1">
        <property type="nucleotide sequence ID" value="XM_022227984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUU9"/>
    <dbReference type="GeneID" id="110975460"/>
    <dbReference type="KEGG" id="aplc:110975460"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000298">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="5">
        <location>
            <begin position="292"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022083676.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="56066" checksum="3FF47EF10FD92D4A" modified="2022-01-19" version="1">MTRGRSLATDFSLMPTKSFNTMLVFSNRNAHKLGSHPVLMNRISKLRQLLNFHCSMTWIQRGSLVPFPCRRSDSVSVHHKLWDNVIWSEAQMREAQKKVEVNSSEYMSPDIGEKLEREAGSQWDGFYSQHQNRFFKDRHWLFTEFPELATSSPSSRPTQQDSSVATKERVGPGTELDLPNLPTDFQQTEHLESKENLSTLMPASEPSNVTATLDGQPDGGDVEEDLPGLPRSDRVSISTAEKSSAQDRGDQAGGSNPIKDIAEERTSSGLTKPQDQLLEEKFPGWDSETRILEVGCGVGNTIFPVLQTNVDPGLFVYGCDFSSVAIDIVKQHHEYNPQRCHAFVYDITDDSAAMPFPQRSLDIIILIFVLSAIHPEKMQESVSRLARYLKPGGLVLLRDYGRYDMAQLRFKKGRCLSDHFYARGDGTLVYFFTQDELRTLFTGAGLVEEQNIVDHRLQVNRGRQLTMYRVWMQCKYRKPTQADRQTDSRDKGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVG6</accession>
    <name>A0A8B7XVG6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Medium-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.3.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110975775</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.7" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022084242.1">
        <property type="nucleotide sequence ID" value="XM_022228550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVG6"/>
    <dbReference type="GeneID" id="110975775"/>
    <dbReference type="KEGG" id="aplc:110975775"/>
    <dbReference type="OMA" id="NYDKMGV"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070991">
        <property type="term" value="F:medium-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000010">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000011">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000007">
        <property type="entry name" value="Medium-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF2">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="18">
        <location>
            <begin position="51"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="17">
        <location>
            <begin position="166"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="16">
        <location>
            <begin position="276"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022084242.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="47549" checksum="367E0CE9D2446C15" modified="2022-01-19" version="1">MALRMTLNRAVKAVANQLPRSQAVLARSRTTASSPETASRPPSAGLAFELSDEQKEYQDLARKFTREEIIPKAPEYDKTGEYPWDIIRKAFDVGLMNAHIPASVGGLGMGILDSCIIAEEFAYGCTGIQTATEANSLGQMPVIIAGNPEQQKKYLGRMLEEPLMCAYCVTEPGAGSDVAGIRTRADKKGDEYILNGSKMWITNGGHANWYFVLARTDPDPKAPASKAFTGFIVERDWPGVSPGRKEWNMGQRASDTRGITFEDVRIPKENVLLGEGMGFKIAMGAFDKTRPPVAAGATGLAQRALDEATKYSMERKTFGKYICEHQAVSFILADMAIGVESARLMTHRAAWEIDQGRRNTYFASIAKALAADVANKCATDAVQIFGGNGFNSDYPVEKLMRDAKIYQIYEGTAQIQRVIISREMLTKAKQMAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVG9</accession>
    <name>A0A8B7XVG9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Testis-specific serine/threonine-protein kinase 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110975657</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084010.1">
        <property type="nucleotide sequence ID" value="XM_022228318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVG9"/>
    <dbReference type="GeneID" id="110975657"/>
    <dbReference type="KEGG" id="aplc:110975657"/>
    <dbReference type="CTD" id="283629"/>
    <dbReference type="OMA" id="EWIQHYG"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14162">
        <property type="entry name" value="STKc_TSSK4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000658">
        <property type="entry name" value="Protein CBG12184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047908">
        <property type="entry name" value="TSSK4_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF102">
        <property type="entry name" value="TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="13" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="45"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022084010.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="38867" checksum="88144C495202DBDB" modified="2022-01-19" version="1">MAVVSKMSAEPTDSASPDTRASAATRKNADNSAKERLSVLEQHGFTSGETVGHGSYAAVKVAYSSRHKSKVAIKIVSKRKAPEDYLRKFLPREIQVVKILKHPNLVCFLQSIETTSRVYFIMELAENGDLLDYIKAQGAVTESQAGTWFHQLVDGMEYCHDQGVVHRDLKCENILLSKNNILKITDFGFARGHMKPVDKRVILSETYCGSYAYAPPEILRGIPYDPMLGDIWSMGVVLFTMMFGRLPFDDTNHKILLQQVQKPPAFPSNRNVAEDCKDLICRILSPAKRRINISEIRENRWFRRIGGNVAKAKKASAVKIKPPSEAKLLGVGGGETDRTASKKIADKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWH7</accession>
    <name>A0A8B7XWH7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110975738 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084176.1">
        <property type="nucleotide sequence ID" value="XM_022228484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWH7"/>
    <dbReference type="GeneID" id="110975738"/>
    <dbReference type="KEGG" id="aplc:110975738"/>
    <dbReference type="OrthoDB" id="5958581at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084176.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="54819" checksum="23DB5AD94CB15CB2" modified="2022-01-19" version="1">MWTRHTRALLTNYMQNRHHCYRAELSTKVYFEDVDAQRNFQRGPKKPLKHLRGEWILRETMTEKTNNEKSGPVEATAMAKQIREQHESSGSVLFRPRKTGSGGYFTERLASIYEVDYSPKTVKPSQPRPCSVTRRNNPHPSHMFMNWKVPTRLIVDDPSYQQQQERLLLDSKQRFYEDINGERKYTSTSGNDVLKEVGKLRGMSPSLLPSRRMARTSTTHHVPPYGMLKHSREKDMEEELKQASAAGNKAPTPGGEYLEDVKVPKLPAVPRSPMKQAGNSDFNTQLSRNLKPRALPAAQNWLKTAGISDTKIISNAMTAADLDRTLGHTLQPDAKKAVENWLQTANERDREVAIEFFGSLAGSKLMGAKKVISDHQIHADDKGQGTCKICDGTRLQQVMDALKKGKPVASVTLKKDSKRPGQVDRRLQLLTPYTRSHKDEYQTWHHLPVFKHTGPVSNTIALFTRPHRPIPRHFTIHPEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XX39</accession>
    <name>A0A8B7XX39_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Biogenesis of lysosome-related organelles complex 1 subunit 6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110976007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084605.1">
        <property type="nucleotide sequence ID" value="XM_022228913.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084614.1">
        <property type="nucleotide sequence ID" value="XM_022228922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XX39"/>
    <dbReference type="GeneID" id="110976007"/>
    <dbReference type="KEGG" id="aplc:110976007"/>
    <dbReference type="OrthoDB" id="19659at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31328">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31328:SF2">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022084614.1"/>
        </source>
    </evidence>
    <sequence length="238" mass="26771" checksum="0782258DD9CE9F12" modified="2022-01-19" version="1">MDESKPSPPASTACDEACLKDTGGDTSPSGKGPNGESAKRSSTNQSNETMTTKDSGKNKPREDVVGELCKDGITEAEDKNSEETVHPLNEPEGKVTKPAAPEQDVLPVDDSIIEKLTMGFLQTFLPQAEYSNAVLDELMRNQRVLIETLEQENAKFKENKMMSELSELMTEAKKYHSKLVHLRKEMMSLHDKSTKLKKRAVKLQHHKMKLNLQKEQQREREMEQEKHLIAKPATKKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYJ4</accession>
    <name>A0A8B7XYJ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110976405 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110976405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085327.1">
        <property type="nucleotide sequence ID" value="XM_022229635.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085329.1">
        <property type="nucleotide sequence ID" value="XM_022229637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYJ4"/>
    <dbReference type="GeneID" id="110976405"/>
    <dbReference type="KEGG" id="aplc:110976405"/>
    <dbReference type="OrthoDB" id="10033658at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029134">
        <property type="entry name" value="DUF4647"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36130">
        <property type="entry name" value="RIKEN CDNA 4933430I17 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36130:SF1">
        <property type="entry name" value="RIKEN CDNA 4933430I17 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15504">
        <property type="entry name" value="DUF4647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="925"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022085327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085329.1"/>
        </source>
    </evidence>
    <sequence length="1147" mass="123140" checksum="0F83BADC57BC2A40" modified="2022-01-19" version="1">MSAVMATDDLLKKYLVEETSCGPLCQHPQCWASNRRVERGLPRLRDSLQSPWTASADEGALPTLKVQNLLAESGLGGRDDYTPAQQPSHHRSSSAPAVDLDNRPQQKFPYTPYTSPMGVRSTSAQSLPSPLQGRQPAKAKSVEVRELFDMDELSSDWQKTFVPSRVYVWCPSKKAYERQLRKEGSQTPATNDQNDSSKPVTLKDMTDLMVPEAPKDKTKRTKKMQKKKPSRITPTGGRPYTHPSRSPPATRRAQPADMDESIAQLLTLPRDILMDVLVHIRNSDSLDKQKVQLLLSRLMPLIHFDANQPQHRSLSPTPLLASGILQNKKMSLLTPQGGGGAGRHGAQPQAGTAAGCQRNPFYLDDGLVAAMTASTYSGLAQQLPMEEGEGGVASEEEVKPSGRMAHQRPLGPISVGVGRKVVGAVPESPQIRNKLTSVSTKSLPPLVPGAKPTKPFDYKGTKSLDLTLGPLPSPDHHSPEKPSTPRSAKASTLYVTLPSVLSPDRTEMTTPLQPYGRVSGPGHAERFANQYLHDTPSPIASEDFPELFWFDNEHPLHAVSPSLSTGVPKAPLGTPATNIHQPYKPLSASQHRPGRSPSPTKQAAGTPHREINPTSAPADPLNADALGTIREVHSELPTSYPGTSAMDTSLPTSPMKHGVTPVSTPWGNCTSITTGALSEGAGRSPVPPLTPQPSTATPEPWPVVDERDFMTSPEKPRDAAPCQAVNLATPTAPPPSPEPQELKNEFEFAVNDMSKSGMTSLTPLVEEGEEEDEEEEVDVGWGKMKEAASPSEDLKDSVEEGPRKTEDIKGDAESKTEKGAFMREDTKEDTESKIGEDASKSEDIIGVKSKVEESAQKSENVKENESNINQEGVSKCEDAKEAVGSEINETGTQETKPEIEGQTHQSAGGVLPCSENDHLMTTCDVTKKDGAAGPDPDTGGEIAAGLLETGGGNSLREAGLAKETPEVQMDKDSSPRTSSQTEQNSAAEVAGDSETVLPTGSPVANDTGRETDDNEGSHDAPGLPDSDPIPDGQDAGITTEHQEDADKDDDVPPNTQVVERLDTTDMSKDEGKTLLDSDRGVDWGREQVQEDNCSSPAECHNAENDQNTGINSHEIPREVKETPAGDADPVNDTEGQISDLGMGITDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0L3</accession>
    <name>A0A8B7Y0L3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Scavenger receptor cysteine-rich type 1 protein M130-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110977150</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086704.1">
        <property type="nucleotide sequence ID" value="XM_022231012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0L3"/>
    <dbReference type="GeneID" id="110977150"/>
    <dbReference type="KEGG" id="aplc:110977150"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000011">
        <property type="entry name" value="Scavenger receptor class A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034006321" evidence="10">
        <location>
            <begin position="23"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="11">
        <location>
            <begin position="39"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="192"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="299"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="324"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="337"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022086704.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="42921" checksum="13CBBF4992C36211" modified="2022-01-19" version="1">MTAPPYILTALAVIVLIGTCFSHPIDTGPGQVRRSSVPCVSGPLGMESGAIEDSRITASSFYDSRFPPRIARLNAGNEGWIPSAPADQWIQIDLSRHVAVTGVVIQGDGRGLNRYVTAFTVQYSASGDSDWHGVLDADGDIRFGVSTGQSTNVTFPVVLMARYLRLLPQAWTTSVYRVRLEVLGCRVSDGTIMLIGGDDALSDRVEIYHEATLSWGAVCSNGWDLTDAHIACRQHHPFLEAVQAGASSAETDLPIVMNQVACKGTENRLVDCPFICTEYQQCNSSHVATVVCRPKMNTVRLVGGSNNSSGRVEVYRNNTWGSICDNDWDINDAAVVCRMLGFPGAEAAKAGAYFGQGSGPVHMDGVACTGSEGNFGDCPSSCWKEPQCSHSQDACVICQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0P9</accession>
    <name>A0A8B7Y0P9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110976687</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085870.1">
        <property type="nucleotide sequence ID" value="XM_022230178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0P9"/>
    <dbReference type="GeneID" id="110976687"/>
    <dbReference type="KEGG" id="aplc:110976687"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034465426" evidence="2">
        <location>
            <begin position="24"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085870.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="39177" checksum="5D38218D15D501D5" modified="2022-01-19" version="1">MCLMNFLNGAVVLFVVTSSFVQASEQDCNEWRHYITNADRFRDELKEKLDILKDNLTALALELNDEHWHGVTSSRQDELQQQLQLPSTLPSEECNSRVNFECIQRFLLVGRRALDNISNQLKGRSHGIINFDYGTVQKTYRLIECYLAEPHWNNQDEAENPCSSTDYSRYLLPSHVSTQDLHYSSHHVLHNLSKNLRRVQHNLTTCINQLRKRDRVDWLKNELEKRTREILLDDDKQYVGLPDETPKRAWAPVGNVYVAVAEDQYKDNLAEAKRDRSALSGPARVADSDWDWGEQVFAPRERRYSKKDLRLVEQLLYSPLQERKKRIPSWMDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0R8</accession>
    <name>A0A8B7Y0R8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glutathione transferase</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110976700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Theta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022085890.1">
        <property type="nucleotide sequence ID" value="XM_022230198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0R8"/>
    <dbReference type="GeneID" id="110976700"/>
    <dbReference type="KEGG" id="aplc:110976700"/>
    <dbReference type="OMA" id="WKSRVQS"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03183">
        <property type="entry name" value="GST_C_Theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03050">
        <property type="entry name" value="GST_N_Theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000008">
        <property type="entry name" value="Glutathione S-transferase theta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000176">
        <property type="entry name" value="Glutathione S-transferase theta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040077">
        <property type="entry name" value="GST_C_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040075">
        <property type="entry name" value="GST_N_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051369">
        <property type="entry name" value="GST_Theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43917:SF8">
        <property type="entry name" value="GH16740P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01153">
        <property type="entry name" value="Main.4:_Theta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022085890.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26550" checksum="CE53A9CA1319F158" modified="2022-01-19" version="1">MSLKVYFDLMSQPSRAVMLFCKVNKIPFTPKPIALRKNEHHSEEYGRINPFRKVPAIEDGHFKLTESVAILQYLAEKYKVPDHWYPKDLQERSKVQEYLAWQHMNTRMHCATVFTHEVVIPRVTGSPPDEDALQTLVNNMHTTLTALEEVFLRDKPYLCGDKISIADLLGICEVLQVTTSGRDVTAGHPKLATWIARVKAELNPHFDEVFALFNRVRDKYMEQKAQQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1S8</accession>
    <name>A0A8B7Y1S8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110977377</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110977377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087129.1">
        <property type="nucleotide sequence ID" value="XM_022231437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1S8"/>
    <dbReference type="GeneID" id="110977377"/>
    <dbReference type="KEGG" id="aplc:110977377"/>
    <dbReference type="OMA" id="LEIGTEH"/>
    <dbReference type="OrthoDB" id="6131956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022087129.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24534" checksum="52F4817A103351D8" modified="2022-01-19" version="1">MLPTGRSMVLSDVSLPGLSTGQHPVILEIGTEHHAGPIDLPDWLLPTFPEFKLDIPYLTASPSSDGAAKLLNYKSIIYTDSAILNAASRLQYNLNASAADMKVTDNSYKVDFNGHTFTANFESSGSYQSADKFPNFSAYVDIMSQTWFGSYQRYRKTCADHHYQFDTIQIRPASMTMQAAKGVLDINFPEGQIKTPDITKALGTVEVLAHFTISHPYDCLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2W3</accession>
    <name>A0A8B7Y2W3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">A disintegrin and metalloproteinase with thrombospondin motifs 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110977579</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087513.1">
        <property type="nucleotide sequence ID" value="XM_022231821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977579"/>
    <dbReference type="KEGG" id="aplc:110977579"/>
    <dbReference type="OrthoDB" id="5855429at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000007">
        <property type="entry name" value="Thrombospondin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF304">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="9 14 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="18">
        <location>
            <begin position="296"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="859"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="948"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1488"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="948"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1492"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="active site" evidence="13 16">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="370"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="410"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="449"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="536"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="563"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="595"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="599"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022087513.1"/>
        </source>
    </evidence>
    <sequence length="1511" mass="168949" checksum="DD32D61417B89ECC" modified="2022-01-19" version="1">MASGISITRWTGPDFLRPSAAFVVLLLAGIRTTVLVSGASIPAIVPLQAKHHHLISKLSQYELVRPYRSTPDGNFLSHDLSTAKEEERNVYERAKRDTLENHRYGGRAARNARSTSHSHRITGDDLHDDLRQNHHFRVDAFGERLTLNVTRNRFLISPKMRVERYNEDGTKDVYRPNVLCYYIGGVNNDPRSTVAISNCDGLSGFIRTGSEEYVIEPLESVVGRSQVNISQGHLHIMYKPKDFKMDATELQTPLTMDLHDDTPDAEENFSARWQETQHTENPSRERRRAGDPDQKHFVETLLAADYSMDNFHRDGLPNYLLTMLNIVNVAYHHESMPFDIQFSASRIIILSRSNRLVVENQAQSSLSNVCRWAAMQTVRDDTQPNHHDLAAFVTRLDFGPAGYAPVTGMCAMTRSCALSRDEGLLSSFVVAHEAGHVFGMEHDGSGNRCSTEPYHGSIMAPVVISTYTDHFWSDCSIQELLRYIGNYECLEDDPFDNGIAEFEGYPGEWYDMDQQCKFDFGNDFELCGSPDDNQACYQLWCIDPYDPQYCRTKKGPPLDGSPCGLDKHCIQGNCIYKDIGRQNGEWSKFSPWSDCTYPCGVGVQVRTRTCDNPPPTNGGKDCKGEAYEYRLCNKKPCVGEWEDRRAKQCEDNLGSFILRGRQHRWLPHENRNQTLQCRLTCISESTQEAVIADYDVTDGTPCSYDDPHSICVQGKCLKLGCDKQVDSTKVEDRCGVCDGDNTQCTFIERHFSQAPKKKYQVIHTLPIGARYIDVRENSQTNSFLALRRPAGKVYILNSRGTQSGPHSFIGAGARFVYSPDTERLFSVGPLREELDLLVFWKRNSKPIDITYSYYLNQEEGLTPQTDPPPTSEQPEVVPTVGEEEPEYVWEDEGWTDCTRTCGGGFSFHQFRCYRTNDNVRVKKTFCGQGDYNPKDTKRLCNEQACGSTLTTTQAAPPTTAPSTQPPTTTVATTQRQTTKPPTTTHRTTTTPQTTQPPTTTQPPTTTTQASPTTWPPTTTQPHTTTTQASPSTQPPTTTQPSTTTTQVWTTTSRPTTQLPTTTTTTTPTLTTTIMTEAPEPTTKKKPKKGKKKAVFKWKAHPWRPCSHTCGTQGTQIRTVTCSKKLGKKISTALEIKCTEEKPATTQPCNREPCPAQWSVGEWSSCTVTCGDGVKNREVTCDAGEFQCPDEEPASTTTCNLGECPQEGPTFRWKAHPWRPCSHTCGTQGTQIRTVTCSKRLGQKISTALESKCTEEKPATTQPCNRESCPVQWSVGEWSSCTVTCGDGVKTREVICGAPESDPGEFQCPDEEPATTATCNLGECPRERPTFRWKAHPWRPCSHTCGTQGTQTRTVTCSKRLGRKISTALESKCTEEKPATTQPCNRESCPAHWSVGDWSSCTVTCGDGFKSREVMCGAPQSDPGQFQCPDEEPATTATCNLGECPEETGCVPMQSIICQRDQFRSYCMMPNYEDICCTTCEEQENLLDEENSKKKKKKKRKKKGRGRSGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y392</accession>
    <name>A0A8B7Y392_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CST complex subunit CTC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110977312</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTC1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086991.1">
        <property type="nucleotide sequence ID" value="XM_022231299.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086992.1">
        <property type="nucleotide sequence ID" value="XM_022231300.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977312"/>
    <dbReference type="KEGG" id="aplc:110977312"/>
    <dbReference type="OMA" id="HTWCLGH"/>
    <dbReference type="OrthoDB" id="2314520at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029156">
        <property type="entry name" value="CTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042617">
        <property type="entry name" value="CTC1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14865">
        <property type="entry name" value="CST COMPLEX SUBUNIT CTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14865:SF2">
        <property type="entry name" value="CST COMPLEX SUBUNIT CTC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15489">
        <property type="entry name" value="CTC1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1074"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1105"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1119"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022086991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022086992.1"/>
        </source>
    </evidence>
    <sequence length="1336" mass="147773" checksum="86E5CA4115C10A1B" modified="2022-01-19" version="1">MWETVTQHALSHLGVSRPGNWQGSSDASYMLHTTQIQHQLKGSWLNTLPSAQSHKCITISELHGYTQVGHSHTENAKCLPQHSALHYHTVNQGLKPIPNTNSFLLAWLTASPNVHRKQEDKEDKRHCPSTGEDELYLKDDTGKVQCQVAICHWGWLNQALLIPCWNVIPGADARVQGLVEICPRCTPVVISSIASEPGRLSDKQQTMLSASAAVQLLQHHNSSKGRVKQVTVKGTLVCKSPIISIHGKPLFFFKLSSDVSGSSSVSFLAKGSNLTFLHCALPMYSSCCVTHVTPTTILKGTRKPYHIYLCRKETTVNVQESCSEHEYKNSVTAAVTKCIDATTGIYELDGNMRLYLCYQMDDSASYQVLRSGCIVTIHNAHYHHLQIGKSTVPCVVCCMQSTLSVDTCSPLDTGPKKKLSPPLSGMVRLLLKYNLTISQLEWLVSVVTQLEKKFTPTLIRHKGLHAILLRLFNTPSTISKEPLLSKRKRNIYEEFLNQSHVCLASKGADNEQTPPWQFPSMAEFSGCIEKCREQLSWHRCMGESLSDDTLIPGEWHCRSILSTSLTPPMILIGYLHLDSATGQVQLKDQTGLVDCVITKAHPNSFESKDTVIYPTPDHNTINPAECCPSKDNSSEVALPLQRKCSFSNCHHMHTWCLGHLIRVEGFLIVQEDLPPSCTGPSGDPGTTAHSSEKEDFNSLSQLRRHREFVAFSMQSVECLNCLNVVQSHSLAKEFQNKTEGGTVTALCQDCSDCNHRGRSWNSSKVKSTNSTQSEMGSFKSTLANDVSIGHSFNTNLFLLLTKSQLLKSLRDSLSFLVHVVILHEQLPEEKGKIAVKLQQQSKLRSAVVRFVGDSVRWYHTLHSGCVYRMQGEVSVVTQQEFHSITSLPPAQLKLEDNSTFLTVSRDLALEQIPGSVLPAHILQQLRVIQSRYKDKLHVSTLQDITADRKSASGSLVSFCCVIISTSDSPGDRIHHFDKKRKTSENPSTRDGELRLLVAGTAVSSITMVVCMSGTSLHSMRGLLPGASVTFRQCVRSTSADGCVICRVTPLTSVTIDTLPSLVPRRQPVQDHTAPPTNQQDSATDTVTTPSTFPQRYQHTAPPSNQQDSPTDTVTTPSTFPQRYQHTAPPSNQQDSPTDTVTTPFISPHQYFLSHLLSCPDSVSPTEVFIINCHLLAIKSLVLKWSCQRCGHKECICSSDSEEGGMLTSSVRFVVEDGSAEALVWCTQPSVIAAVLGLTAQQWTQLELEIRRCKEVVYSYKKPNYREKVVLPSPTDTEGLVNLLCSDDSLQKPLVLHCQLRNRGTSMRSSSANAGTADKQFAPSVHLKCLAAYEGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y598</accession>
    <name>A0A8B7Y598_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110977545</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022087510.1">
        <property type="nucleotide sequence ID" value="XM_022231818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y598"/>
    <dbReference type="GeneID" id="110977545"/>
    <dbReference type="KEGG" id="aplc:110977545"/>
    <dbReference type="CTD" id="128"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="37"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="208"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022087510.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="40378" checksum="017497F68E10A1FE" modified="2022-01-19" version="1">MHAPPPEREPITCRAAVAWEAGKPLSIEQVEVGVPKQGEVRVKILATGVCHTDAYTLSGIDPEGKFPCILGHEGGGIVESVGPGVTSVAVGDHVIPMYVPQCRDCKFCLSPKTNLCQKIRVTQGKGLMPDGTSRFTCKGQEVSHFMGTSTFSEYTVLPEISLAKVNEKAPLDKVCLLGCGISTGFGAALNTAKVEAGSTCAVWGLGCVGLAVIMGCKAAGASKIIGIDINNDKESLARQFGATDFVNPKNYDKPTPQVLSEMTDGGLDYTFECIGNVKTMREALESCHKGWGVSTIIGVAGAGQEISTRPFQLVTGRVWKGTAFGGYKSRDGVPQLVEDYLGGKVKVDEFITHHVNFDQINDAFDLLHSGQSIRTIVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5C3</accession>
    <name>A0A8B7Y5C3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110977704</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat GAD-1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087742.1">
        <property type="nucleotide sequence ID" value="XM_022232050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977704"/>
    <dbReference type="KEGG" id="aplc:110977704"/>
    <dbReference type="OMA" id="KGDQYIT"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001038">
        <property type="entry name" value="WD repeat domain 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000294">
        <property type="entry name" value="WD repeat-containing protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022087742.1"/>
        </source>
    </evidence>
    <sequence length="681" mass="75593" checksum="1B2708BEB490717B" modified="2022-01-19" version="1">MADSDDDLEEMRLLRNCARGRGGGNISASMRVDHEDDSEERSAKLEDDMAKVMGFSGFGKKARTFDVSAMFEQTRRTAQQLTAKKPEGTVQPAKPSGKRAERADSHKSSDSDDSEDSSDSDTEMIGPPMPPGFQAPTTSKTSSSKANEVSQADDESDVDDDEIDDNQEEEDDSLVSKIPASHEIVLNHGPKTVSAISLDPSGSRLVTGGYDYEMKMWDFAAMDSSLHSFRSLQPCESHQIKTLQYSITGDCILVAAAKAQAKVIDRDGFEVMECAKGDQYIVDMAKTKGHVAALNGACWNPKVKEEFITCSDDGXELLVKQRTLRIWDFNQPKRQKEVIKFRSVGGRKTVPTCCTFSRDAKLIAAPCQDGSLQLWDVKKPFIRPTYHQKTAHAVGSDSTCMTFSYDNRVFATRGGDDTLKLWDLRNFKRPINVTTGLINYFSGVDCLFSPDDKMIVTCTSVKKGEGEGKLVFLDRETFDTVTEIPCGDAGVARCLWHPKLNQIIVGCGNGDAKIFYDPNKSHRGAKLCVVKKKRKAKEPDIVRNDHVITPHMLRMYRKDQPKLLMSYKQSQKDRQDPLKSHRPDLPITSGRGGRVGSGGASLSSYVAKVIAVNKKDDSNPREAILRHAKDASSNPYWIAPAYSQTQPKAIFQEESDEEEEDNTDVPHWAKKQKLDSDKTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5P2</accession>
    <name>A0A8B7Y5P2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C4orf45-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088509.1">
        <property type="nucleotide sequence ID" value="XM_022232817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5P2"/>
    <dbReference type="GeneID" id="110978106"/>
    <dbReference type="KEGG" id="aplc:110978106"/>
    <dbReference type="OMA" id="CHYVNAS"/>
    <dbReference type="OrthoDB" id="6140842at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027814">
        <property type="entry name" value="DUF4562"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34833">
        <property type="entry name" value="GENE, 17359-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34833:SF1">
        <property type="entry name" value="GENE, 17359-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15123">
        <property type="entry name" value="DUF4562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088509.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15605" checksum="51FFFB85215D0D71" modified="2022-01-19" version="1">MSSLMAQPADGKASKSRPSTCASSNSHETWMTPRGNTRMGKGVVVFTGPDGRKNQDVKVNEDNRYVGIGATSPEKSSELLYLYRPATGAPFHRAKCDIPGSIGWGLPRTEDPRTWPVHLKICTPEEFKQSRENSQGIWNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5P8</accession>
    <name>A0A8B7Y5P8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977757</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087872.1">
        <property type="nucleotide sequence ID" value="XM_022232180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5P8"/>
    <dbReference type="GeneID" id="110977757"/>
    <dbReference type="KEGG" id="aplc:110977757"/>
    <dbReference type="OMA" id="HEPQMDE"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="66"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087872.1"/>
        </source>
    </evidence>
    <sequence length="618" mass="68376" checksum="3AE4C55993C33732" modified="2022-01-19" version="1">MSVMADTIFYGGDIITMEEPNANPRSGADPPPKVEAVAISGDTILAVGTIDAVFRHAGPQTQVYFLNQQTLMPGFIEPHQHAIQCALMRSQYTNIGALSYRSYDDVHAVMVNRISELAADPNNESWAIFFGWDPELIPDLPTLSADFLDVNFSSTIPIVVIGQSGHVAWVNHPALKAPKPEIGHNYQSPPGGTVVLDAEGRPTGQLFEEPAMMLVMKEAPLPSEQAMAESFYQQWRSYASAGLTTVTDLAYMPMPELDAVLKKAADAKDFPVRLGLYKMIHAVKDADVTKSPPFPVAQGQCVSQLIRIGPKKEKTAGEGVGNYNSRLWEAGLKLVADGSPHCGTAATREPYLFTPLTETLGFPKAPGYGVLNMETDALFDTVKRHHQEGKQLAIHCHGERSSEQALKVYEQVLAQFPNQDNRHRMEHLGLMTVDQIARAGKLNLALSFFVDHLRFYAKVYKTDIFGDRVDRWTPLSEATKSGVTWTIHQDHPTFPGEANPFANIKTAVTRCTRDDPKTPYGPEYRVSIHEALKSYTVNAAWQLHLDQKVGSIKAGKKADFVVLSENPYDVDPLDLERIRVIETFVDGRRNNLANIKTIPTVNVKVLDRSFQQVQSATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5Z6</accession>
    <name>A0A8B7Y5Z6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110977816</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110977816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087962.1">
        <property type="nucleotide sequence ID" value="XM_022232270.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087963.1">
        <property type="nucleotide sequence ID" value="XM_022232271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5Z6"/>
    <dbReference type="GeneID" id="110977816"/>
    <dbReference type="KEGG" id="aplc:110977816"/>
    <dbReference type="OMA" id="QWPAISV"/>
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    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Amidase"/>
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    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
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    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
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    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
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    <dbReference type="PANTHER" id="PTHR11895:SF151">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
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    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
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    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022087962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022087963.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="49914" checksum="69F9395D645EAB6A" modified="2022-01-19" version="1">MYHLNIKDLLQRFSDGTMTCEAYTRRVIQRAQDLKVFNYFVSMDTERMLKDAQEADARYRNKTNRPLEGVPIAMKDNIDIEGEETGAGTPGLAGLKPKHTAEVARRLFDAGAIHAGRVNMHELASGASTCNAYTGASHNFHNFDYTCGGSSGGSGGVVSADIVPAALGTDTAGSIRIPSSYNGVFGLRPTSGRWPADYGVKMTHLRDSVGPLVRSAEDIAILDSIVTGEEPHGELSPEEIRIGVPRPLFWEALDPEIEDHAEHFLAKLKEKGFVIVQGPEIPGSREMVEKYLLPTIHYEVVPRLDEYLRYHGHSVTVQSVIDKIASPDVKVVFENVIDSPPTEDVFESAIAARAKVREDLKTYFEDYRLDCILMPANKILAPTLHIFEGNNVELCRLITQNDDLANICNNPSLVIPGGFAQPSGVPFGMQIESYTGSDRRLIAVAVAIEKALRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6D7</accession>
    <name>A0A8B7Y6D7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110978253</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088774.1">
        <property type="nucleotide sequence ID" value="XM_022233082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6D7"/>
    <dbReference type="GeneID" id="110978253"/>
    <dbReference type="KEGG" id="aplc:110978253"/>
    <dbReference type="OMA" id="GANKEQC"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF165">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088774.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="24289" checksum="3076E7DF592FBB1B" modified="2022-01-19" version="1">MSSRTLSQGRPPIFFMLPAGQQHGKLGGAIAVMGDAVKILGLTQFLTAIPCIALGVAALLFECQYGYIATGIWVGAIVLVSGLLGVSAGSSKEQCPLSSYHMMSLLNILSGTALLTIHVLSLLRELANCADTTKTCSALCVTFNNLLGCIGLVLFFLALAAAVVSMTLNNKVGKCKEQVVPLMPYPVRHGNRSVTKSIKGTEAEQNGEVTRGDIHLQNLNFSDENFQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8Q1</accession>
    <name>A0A8B7Y8Q1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein LOC110978224</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110978224</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088735.1">
        <property type="nucleotide sequence ID" value="XM_022233043.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978224"/>
    <dbReference type="KEGG" id="aplc:110978224"/>
    <dbReference type="OMA" id="PINCTHF"/>
    <dbReference type="OrthoDB" id="10002959at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000024">
        <property type="entry name" value="Serine protease 53"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 12" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="16">
        <location>
            <begin position="198"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="370"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="17">
        <location>
            <begin position="618"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="739"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="925"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="17">
        <location>
            <begin position="1174"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="1186"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="1295"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="17">
        <location>
            <begin position="1592"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="1665"/>
            <end position="1794"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="1865"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="17">
        <location>
            <begin position="2155"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="2228"/>
            <end position="2357"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="18">
        <location>
            <begin position="2428"/>
            <end position="2672"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="17">
        <location>
            <begin position="2718"/>
            <end position="2786"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="2783"/>
            <end position="2884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
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        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022088735.1"/>
        </source>
    </evidence>
    <sequence length="2884" mass="318982" checksum="D1061857A6F25231" modified="2022-01-19" version="1">MTEVLSERVTLNLASLSDTDIGHEKALQCPTELSMQPIAGGKDGHDSRDKNQQSTDANANLTTNSGAQDGSAQNSGVTAVDESDAIPVDGTLLDKEYESTLEEGCYHNPAFEPDGGLVKFSQPLSKEQGYLSQPSSTSCPVCSRMTVIAAIVIAFCVVIAVIFFMVGHFSALGWSSSGLPQSVSTSSSHLTTVSQPRVLVEVAASLTLQQDYLMVYGDPTSVEYNTLARKFAFYVSKIFGNSHLQESFEKVEVERFRPGSVLVDFVIRLDWKPSPGQETTNESYLQAIIKTEVEYALNQGISRDQGQEFEVEPGSITVPTVNLLKDGDTVTLMPTPVVTSFGVTTERTGVLNTEDCGLRPGYDNQPLSRVVGGQRSDWGKWPWLVSLRIRRDSTSEKKRHNCAATLISDQWATTAAHCVSMPNTFAVKLDSIVAGDLQLEVTSPHHQLIPVERILPYPGYNSLNYLHDLALLKLVRPVEVTDYVRPVCVGNEPLEDYDNCYIAGWGFTQYSGNISNTQLDAEMRLIDLANCTQDYEKYKMFGFTPTDAAVCYVSSRDFSSPCNGDSGGPLMCQKGDNRWYMVGIISVGIACNTTWQPSIATRVSAYLDFISASVNGDYRYGQCEDIQSEICSRVLPYQRIFSTDQSHFDPVIELMLAILNQSCSEHIDLLLCSLLYKGCGEGYRSLVPCRAFCRTVVEECREYQWTDDLLLSDVIKCNMFPEAWNPNQRICYEDEDARCGNQSTIMLASFGHERLQSHNFIGPYGEHLDCVYVITAPPGHQVVAKTRKMDLHRSDILAFGEGPDAYDKTTLLQRFEGEAEPPVIVSEGEVMWIRFTSGVFMAEDVEGYDLEIHAISHENASALCSTDSANELFSIPDWWKCDDIMDCPTGLDETNCSRKLPDDLNTALCGVRPAIPREDSLAFRIVNGTKVEMGGWPWMAYLRLDNVTNGHIVCGASLIADRWLTTAAHCVSSPNAFGMLISNIVIGDIHLMEESRYHQTVPVERIYTHPGYNPKILTNDIALLKLARPVEMNNYVRPVCLDLPTEDDVTEKYTKCFAAGWGFTQYKGNRSNDLLEADMSLVELEDCTDLYAGYQMWGLTITDRVTCVKPAGTNVSATACNGDSGGPVMCLSTDGRWNMVGIISLGIRCSAHPVVVTRVAAFVSYIANVMKGDPNPVKCEKVQSEMCSGQLPYDRTFPTSQESFDPVVAAILENVTCPSVNLTLFACSLLFEGCTEDGRAQVLCREYCEQVVDECTWAFLKATGRFFGIIAKCFTSPEAGRQDQMICYKDEDARCGNQTDILLPQEGSVSLQSHNYPDHYGMFLDCTVLITAPTGYRVLVKVRDFDVEKCCETLAFGAGRDAHDKRTTLAKFHSQEDVRLVLSPTTSLWVRFTSRDNPNADEKGYSLEVYAVLGTDQFVWTQLLKILTIPVCAIAGWGLTNYTAADLPNHQQESEVRLVSLQDCIQSVQGVGLYGIVTNNIICAKGLDGQSPCSGDSGGALVCRNQHGVWHEVGIISAVFGCSSKKYPGFYTRISSYVAFISSVIRGEFQPSCEPLEPSNQCTDLVPYADTYSTNQSYYDDLIDHLSSLEMCHSHANQFLCMMFMPGCSRGEVPCRAFCQEFVDNCSSVYEDATGAFLEWFILCEHYPVGRPGEMTCSIGSDARCKLSHSDFIIRVPASSHVTLYSPRYPLYEENLECFWIVVGPPDYHRLLIKFVALDYNWEGNNALIVGYGDNPGNLSTQLGRFSGADKAGPVLIQSDTAWIWYGTGSGEQRPAPGETLKLLGGFQLEIHATNITDLSLLCTVPEGGPSRALTTMPAWWHCDGFPDCPAGADEHDCSLPWYNQTYILNQAGCGLQAASNSFRIIGGSDAEPGQWPWLGSLRYHGNDGSKNHGCAVSLVAPQWVVTAAHCVDTPFYMNHRIDVVFGNPKLNETTVHQVEVAVETVFPHPGFQPHLLAEHDIAVLKLAEPVAYTNHVRPVCLDTAAEDFDNSSLCYVAGWGLTNYTAAVSTNRQQELEIRLVSRQDCIRSLQQIDFYSLVTDNMICAEGLDGQSPCRGDSGGALVCRNQYGVWFEVGIISLSFACSSERYPGVYARISSYIDFISSVISEEFPPSCEPLEPSNQCTNLVPYLDTYPTDQLLYDDFIDLLPSFEMCHSHANQFLCMLFMPGCSRWEVPCRAFCQEFVDNCSSVYLDAKGMYLKWFMSCENYPVGRPGQMTCIKGADARCELSHSGTLIDVPASSHVTLYSPRYPLYEETLQCFWIVVGPPDYHRLLIKFVAMDYDWEGNNALIVGFGDNPSKLSTQLGRFSGADKAGPVLIQSDTAWIWYGTGSGEQRPALGETLKPLGGFQLEIHATNIADLNSLCTVPDGGPNTDLRTMPAWWHCDGFPDCPGGADEHNCSLLWYNQTYVLNQAGCGLQASRQPFRIVGGSDAEPGQWPWLGSLRYHGNDGSKKHRCAASLIAPQWVVTAAHCVVTPAYMNQRLDVVFGDPRLNEMTVHQVEVAVETVFPHPGFRRHFLPEHDIAVLKLAEPVAYTNHVRPVCLDTAAEDFDNSSLCYVAGWGLTNYTAAELANHQQESEIHLLPQQDCIWLLGGFKDTDIPINNIMCAEGQDGQSPCRGDSGGALVCRNRHGIWHEVGIISIGFGCSSAIYPGFFTRISSYIDFISSTINGEFQPSCEPLEPSNQCTDLVPYADTYSTNQSFFDDLIDHLLSFEMCHSHANQFLCMMFMPGCSLREVPCRAFCQEFVDNCSSVYLDATGMFLEWFIPCEHYPVGRPGQMTCANGIDARCELSHSGTLIDVPASSHATLYSPRYPLYEETLQCFWIFVGPPDYHRLLIKFVAMDYDWKGNNALIVGYGDNPGNLSTQLGRFSGADKAGPVDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8W1</accession>
    <name>A0A8B7Y8W1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NXPE family member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088982.1">
        <property type="nucleotide sequence ID" value="XM_022233290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8W1"/>
    <dbReference type="GeneID" id="110978352"/>
    <dbReference type="KEGG" id="aplc:110978352"/>
    <dbReference type="OMA" id="AFFLPVW"/>
    <dbReference type="OrthoDB" id="5950832at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NXPE C-terminal" evidence="1">
        <location>
            <begin position="209"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088982.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44920" checksum="DC0A6659F9E01E3A" modified="2022-01-19" version="1">MWDKATFDDFEPAAFENFKAYNNTNRPLDMGLTSYNMTVVKLISPTSPRIRVGDVLKYRIESRDFKGRNRIVGGDFWYATLTSDRSPKASTTGYIADYGNGTYDAFVLAAWPGSAKFNLILVHTSETVYHMRNTVWNSEGRLFFRGYYRFNGKNADGRCSMRRQGTWEAMCDYPAYKSLGSTVLLCEHKAGFPCESLVSLGIDSNHIKYSAKQMAKDFEYLYKSAALSNHSLSLHFHGYVIASHTYTITNWKEEVDALNELNSTHCSYIVLINQWAHFAQWTRDSYIERVRLIRQAVIGLLQRCPDVPVVIKGPHARQHESVGSIIFGSDYFLKDIELINQEAFQGTGAFFLPVWDMNLAYPSSNDVHMPMEVVGEELKMFLGYACDKLMRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y952</accession>
    <name>A0A8B7Y952_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase-activating protein 24-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110978403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089077.1">
        <property type="nucleotide sequence ID" value="XM_022233385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y952"/>
    <dbReference type="GeneID" id="110978403"/>
    <dbReference type="KEGG" id="aplc:110978403"/>
    <dbReference type="OMA" id="RTYYIHA"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045188">
        <property type="entry name" value="Boi1/Boi2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="43"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022089077.1"/>
        </source>
    </evidence>
    <sequence length="151" mass="17040" checksum="768B31AFE06BD7D5" modified="2022-01-19" version="1">MATDRVEEGDDGQTKVACITTADSTLNTLERTTLNGPEAGVTENLKCGWLTKRSKLSHKWEKRWFLLKSSMLYYGNDAENLHKNIPLNGTEIAEADVDRKQFVFRLKPSESRRTYYLQAACQEELQEWMQAICFAKAASRQGGASQACSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9Y2</accession>
    <name>A0A8B7Y9Y2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110978103</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088506.1">
        <property type="nucleotide sequence ID" value="XM_022232814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9Y2"/>
    <dbReference type="GeneID" id="110978103"/>
    <dbReference type="KEGG" id="aplc:110978103"/>
    <dbReference type="OMA" id="VWQAQWF"/>
    <dbReference type="OrthoDB" id="406745at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016715">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00538">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053251">
        <property type="entry name" value="N-glycanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015197">
        <property type="entry name" value="PngaseF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015196">
        <property type="entry name" value="PngaseF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39319">
        <property type="entry name" value="SI:DKEY-256H2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39319:SF1">
        <property type="entry name" value="SI:DKEY-256H2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09113">
        <property type="entry name" value="N-glycanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09112">
        <property type="entry name" value="N-glycanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01290">
        <property type="entry name" value="N-glycanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide-N-glycosidase F N-terminal" evidence="3">
        <location>
            <begin position="420"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022088506.1"/>
        </source>
    </evidence>
    <sequence length="712" mass="80174" checksum="75CA5F5AB6CCA66E" modified="2022-01-19" version="1">MLLINQMEVQKISINVGLLLLLWLCINFRVTSGIQKHVQTLRNGNEQSKTSSWSRVRQQLQTGRENLAHRRGFSQTVFTDWEDQTPALLPDQPAQPFRLFTLNGVIEYPSALLSNTPMIFHTFNNHSGFLECLWTSESSLQTLIKGRPSNTHFVFLPTSDDPLKETLWMREQIQGAVERMGLLERDGGLQSQFHFAVTSLYQLGNWIPALLQQWACQDHGCGLAQVVFQSAPTSYDSKEISNQISAPIVLKRLDARYDWLPSVDKFGNQTIPVVPAENGCKPDSRVAKKIAVVMAGSCSFSTKVTTMEQSGAAGVIVYADQGQPVQDMNCEGAECDSPPAIPATMVPFNQDLVTRLQKEKLYVSFQTTPTDNFYFGINAEGLLQEMGWLLYPSFQFFNWQAEWFNYKSSLLRNLSSEALVIPVIKNSLMQGNTGVVKAIQLPSLLKLSQYNKFELDASLSCPGTKDESCPPWDHTVHLYLCCNETSPLCNMELGRWITPFRRRIGRWLTDVSPLFPLFTSDTCNFTMKTVPWAKAWEPSLNLRFSKDSSGGTLRPYNITPLFRGGTFDKNYNKKYKPLFFTVPSDVKKVQVFAVITGHGSDNNGCGEFCVTSHHFVINGHHHNITFSNAGTELGCAMRTPTGVEPNEHGTWLYGRDGWCDGREVDPWVFDVTAQVTSGQNNITYFGWFEGKDPNPTGTPGYIIMYSYLVFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YB96</accession>
    <name>A0A8B7YB96_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor HES-4-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979201</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090493.1">
        <property type="nucleotide sequence ID" value="XM_022234801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YB96"/>
    <dbReference type="GeneID" id="110979201"/>
    <dbReference type="KEGG" id="aplc:110979201"/>
    <dbReference type="OMA" id="GFAECMG"/>
    <dbReference type="OrthoDB" id="6085656at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11459">
        <property type="entry name" value="bHLH-O_HES1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000009">
        <property type="entry name" value="Transcription factor HES-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050370">
        <property type="entry name" value="HES_HEY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003650">
        <property type="entry name" value="Orange_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10985">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, HES-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07527">
        <property type="entry name" value="Hairy_orange"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00511">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158457">
        <property type="entry name" value="Orange domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51054">
        <property type="entry name" value="ORANGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Orange" evidence="8">
        <location>
            <begin position="87"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="332"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090493.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="47819" checksum="261FDD37DF26203E" modified="2022-01-19" version="1">MMTSADMEKQTMKASKPAMEKRRRARINESLQQLKALVLDGINKNNSRHSKLEKADILEMTVRYLRNVQREQVKASFETDPSVMTQYRTGFAECMGEVSRYLGSAMEENPEVRARLIGHLAGLCTSTNQQRQPARYAGVSNGQMQSPGTGQVQPSSPTSNRGLVVVNAASSTAPISAAVRHHQTPPLQVCFPTPPLSSGGPVSHQATFMTSPAVEGTRTGGGSQVRGPHAPQLQSQRPSPVKGAGGDSSSASKPELSGSEVKLPVMAAQNLPRESAPQAVQPAANMITLILPSQSLPGGQVPTHLIPVYAQEPGKDATPSLGFSFASSNTVAATTSPRGTDSGDTSPRASTASTPTPKASLTAPSTVATGQPAVWTAIPPPAAQLVSPHAGAVAPTALAPPFTFSLPFNAKVSPPGMATQAKHPTEQMRHPIRFPGVFAVSTEASGDTDPVWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCK6</accession>
    <name>A0A8B7YCK6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">28S ribosomal protein S22, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110978991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090110.1">
        <property type="nucleotide sequence ID" value="XM_022234418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCK6"/>
    <dbReference type="GeneID" id="110978991"/>
    <dbReference type="KEGG" id="aplc:110978991"/>
    <dbReference type="CTD" id="56945"/>
    <dbReference type="OMA" id="GYIELTL"/>
    <dbReference type="OrthoDB" id="10052321at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019374">
        <property type="entry name" value="Ribosomal_mS22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13071:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10245">
        <property type="entry name" value="MRP-S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022090110.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="41122" checksum="79790D0F4B680B2D" modified="2022-01-19" version="1">MATYIMRCQRKLSEECAQLIRQIVLQKRAGAVKNKQFSCYSNLQGSQKDASDLFRTDEVQGILTRITGMDLSKVFRHSKQKLEPPTYRLIGDTKLKELEEEAKNEAKKRLQMPPVLDEREEITDILSENPELEGLDSSKFVFTDITYGIKDRERFIVVREPSGTLRKATWEERDRITQIYFPRPYRNLVPPPLFDDENLSVMFCQDRHQDLLDAACVQFEPDAADFIRVHQQAYEDIDAKEKYDLLRSTRHFGGLVFYLTRNQRIDGMLSDMVQRNLISDGVDLVRLYHLLHPECQSSAEVRTKELEGIDIIKAFIATDAKRKGNLELVLQVYENERASWNATTDHQGIVETQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YD80</accession>
    <name>A0A8B7YD80_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110979108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090340.1">
        <property type="nucleotide sequence ID" value="XM_022234648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YD80"/>
    <dbReference type="GeneID" id="110979108"/>
    <dbReference type="KEGG" id="aplc:110979108"/>
    <dbReference type="OMA" id="WWDEQPG"/>
    <dbReference type="OrthoDB" id="10385839at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022090340.1"/>
        </source>
    </evidence>
    <sequence length="147" mass="16921" checksum="CFC98815EA41F5E1" modified="2022-01-19" version="1">MVLQTGAKISFTVIIFVFQADAFLSEWTLRAPCDDHFFHQSTNIHGAGDDDNSCTVFLEEKYYEDKSSKLPLAVFLTCLAIAALYTFRVLSARDCPRVSQSALKKDTQLGLMKRLRVHWWDEQPGLPLLNWERCPSCHRLERLQLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDK7</accession>
    <name>A0A8B7YDK7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Uncharacterized protein LOC110978774 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110978774</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089736.1">
        <property type="nucleotide sequence ID" value="XM_022234044.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089737.1">
        <property type="nucleotide sequence ID" value="XM_022234045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDK7"/>
    <dbReference type="GeneID" id="110978774"/>
    <dbReference type="KEGG" id="aplc:110978774"/>
    <dbReference type="OMA" id="IVVSQCH"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04371">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051548">
        <property type="entry name" value="Grx-like_ET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34386">
        <property type="entry name" value="GLUTAREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34386:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN NRDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="132"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022089736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022089737.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="54814" checksum="95E6E347F5CC7DD0" modified="2022-01-19" version="1">MKGQILVYSIVGCPHCMKAKSTLNELNLPYVDVSVDKYDISVRKSLVERTGKRTVPQVFFNSHYIGGNDDLQELIRDKESLQRLIQDVEDNEPPADAPEVPDPSLKIGSAAGDEFNFTCELDECALLVKDLKESGLISDNRRGLKVYKNTFVGREFVDWIVKTKDVDRERAVEIGQALIEQRFGHDVKSSHEQVFEDSDRVYRLIEDDPATALNQGMSSLCEPRPASELGEELRKLILDLYNQHLTRDGKGVDYPGIKDSPKFQQYVKHTAELVRVDIAAATREEKLAFFINVYNALVIHANVTQGPPTNIWQRYKFFNRTCYIIGGHIYSLQDIENGVLRGNRKGIGQFSRPFSKSDPRFVIALETPEPLIHFALVCGARSCPPIKTYSAKGIYDQLKLAAEAFLESSDGCLVLPGKNEVRLSKIFQWYKVDFGGTDAKVVQWVYDHIGDGEKKMALGKMLSSGNFKTSYLTYNWSLNSKHGSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YF16</accession>
    <name>A0A8B7YF16_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kanadaptin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110979471</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090980.1">
        <property type="nucleotide sequence ID" value="XM_022235288.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979471"/>
    <dbReference type="KEGG" id="aplc:110979471"/>
    <dbReference type="OrthoDB" id="433755at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd19856">
        <property type="entry name" value="DSRM_Kanadaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22677">
        <property type="entry name" value="FHA_Kanadaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000088">
        <property type="entry name" value="Uncharacterized protein ZK632.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="750"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1235"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090980.1"/>
        </source>
    </evidence>
    <sequence length="1365" mass="153486" checksum="66003578237F7C9F" modified="2022-01-19" version="1">MLHGDQRDSGPYPVLSCGWFERLVDQRQGRETLDSMGGVSTSYVHGRRRHGSWKWFSPTIALMLMCTVPCLWMIEWDVYKQRRGCGKINLNDDRNPSPCDDSYFNKTSLPPIFGHEVPFVAMILPDWALALHQMLLFSLILGRWLLPKGELSRDQLSQLLLVQVGMAADILEFVGEGLKVDEIYDNDVHVLILLSVWTWSLPQFTLSLTLTKGRKTRVAGVRPLAAEHRKKPLIRVQRDGESDHCHFFCGTETWAILVTLMMQDLPFLASRLYLIISPRVPLSIPFLFFTSKNALLTVLQLYRLAVILHEYREKRKARDRRVGAKLSRSESTDLRDATVGRTDEPILIDDLDKTPSLWVTSRFFYGSGEDRQHLRHRKHVSVQTEWPCNVVDDNSVFLNHRRISDHQDDVNNEPSPEKCINQNTSSTVGSDSSFGQSGNKNVFVFLVDFSDGEEKDRNDDVHSGGSEQGIEHGNGDFSDASPGSDDEQDAGDEGGRDRAAGVDDEEGVHNGGSNDPVTEMERESESTDPNHANISKECAAVDISSLPNMPSLDQRQRSPGSETRCPTENSGGFGGEKATIERSHEVSESNMSKQDEGGFKLPGLPLPTKTGHAGPKKFHSPASATLENRTNNVKPDESKDKTDHAFQPYSEEFNFPKPKQSNIPKHKKDPQMSGPIPGAEQSSPQEQPLLPASTVKKSREKSPAEKLAKAPPLPYIEPSWSGVPNEPYHLEVLKSGAIIAKIPLNDKAYHVFGRLEICDIPLEHPSLSRYHLVLQYRLMGDSEHDPGFYLYDLGSTHGSWFNKQKMEGRVFYRMRVGHMFKLGGSSRMYILQGPAEDQDAESELSVTELKELRQKQLAELEDRRRATQEQAANERREEKERDEGISWGMDYEDAQEEDTRGDNPFAIMTQEEKEATYIKDPKKALRGYFEREGYDLEYNVEEKESGFNKQFVCKVELPLDDASGRPIFAEAAVVGKKKEAVVACALEACRILDAHGVLRQATHESHKRKVKNWKEDDYYDSDEDTFLDRTGEIEKKRLQRMKKAGIIKEKAQTYDSLKSHLSDVETEMQKIEEEMSTQSKSSASAVLQDDSLDAFMESIQGGKTLDKTWRAKLKLRLIELKKEQARLSRLVDIAKPATMPALQKSSTQTSFAAFSKKLPMFGSMKGHAGLRPKLKTVMQSPTAVPVSSPSQRAIEEKQEVEEEEDEPIEVASPPAATSSSEHTRVELLDKPLTASRPSSVSAPTHSTSTEHKPDPAVSKSHSPLPHARKLGPSLPTKIQIQNEWEAKDSTGRSATSLAREERSPTKKPRRARDDSGSAKRTRMSEETLRQREMAEMEDKEDFTDWTPPIGQTGDGRTHLNAKFGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YF85</accession>
    <name>A0A8B7YF85_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-glucuronosyltransferase 2C1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979981</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091899.1">
        <property type="nucleotide sequence ID" value="XM_022236207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YF85"/>
    <dbReference type="GeneID" id="110979981"/>
    <dbReference type="KEGG" id="aplc:110979981"/>
    <dbReference type="OMA" id="IARSHYN"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000021">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034173317" evidence="5">
        <location>
            <begin position="20"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022091899.1"/>
        </source>
    </evidence>
    <sequence length="551" mass="62799" checksum="2296AEECA67FC16B" modified="2022-01-19" version="1">MNSALSAWTLLLMLMCFSAAPLPTGCEETKQDFKKYKFLYYSFEKLGSHGMQLSQSGKVLARQGHDVFFLVGSDGPRAPKTNDNDLFSFIFFQSNYTTEGRRDVFRELSHYSLSGELSSAAGIARLILRTLRTGKPLVIYLLIDECDALLRDEKTMARLRREQFDMMVADDFSLCNAIVAEALDIPFVQLANWCAMPDKYGPLFRVPTDPSYIPAHQLGFTDRMTLSQRVINYIFHWTSEYIFSDFPTRYQQLKVKYNIKPEVHITESLMKARLWVFNMNYPLEFPRPMQPNTLMYASLIGGKRENYTLRDDVAKFVDEALAGFVIFSLGSHVEAMEVEQAQMFADGFALLPQKVLWQSNINFTGLNLGENTKMVNWIPLLQLLSHKNAKAFVTQCGINSVQEALWAGLPIVSIPLLHDMFDNNDRAVARGFALSLGDITSVTSDRLRDAVVEVVNNPKYRKNAQHYSAILRDLVRMNPPAETIANWILHVTKFGGNHLRPAVFDLNFVQRNLIDVYLILLLVFAVICGANVLLWYTCCSRRRGGRRPKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFH4</accession>
    <name>A0A8B7YFH4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Enoyl-CoA delta isomerase 2, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110980022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091978.1">
        <property type="nucleotide sequence ID" value="XM_022236286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFH4"/>
    <dbReference type="GeneID" id="110980022"/>
    <dbReference type="KEGG" id="aplc:110980022"/>
    <dbReference type="OrthoDB" id="409763at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Enoyl-CoA delta isomerase 2, mitochondrial"/>
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        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
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        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
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        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
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        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
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        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
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    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
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    </dbReference>
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    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
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        <property type="entry name" value="Acyl-CoA binding protein"/>
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    </dbReference>
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        <property type="entry name" value="ClpP/crotonase"/>
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    </dbReference>
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        <property type="entry name" value="ACB_2"/>
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    </dbReference>
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        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004275"/>
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            <dbReference type="ARBA" id="ARBA00023140"/>
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            <dbReference type="ARBA" id="ARBA00023235"/>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51228"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
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            <dbReference type="RefSeq" id="XP_022091978.1"/>
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    <sequence length="403" mass="43864" checksum="322FCE0913981746" modified="2022-01-19" version="1">MALAATRLATKFLRLGNYQGASVLQRRCFHQTAVMGVTDAEFSAAKERVGTLTQDPGNEVKLKMYGLFKQVAVGKCNAPKPGAFDFVGKAKWGAWNDLGDMSKEEAKEKYVDLVNDLVAKDPGAKATSAPAGTQEGTSAASSSTGGYENLKVTIDKGVCTIMMNRPHKKNAITRETYEEIIKALDSSGRDDSVVLSALTGAGDFYSGGNDLNNFMSITPDTMKQAAKDGGELLERFVAAFIDFPKPLVAAVNGPAVGIPVTSLGLCDVVYASDRATFHTPFSSLGQSPEACSSYLFPKIMGQAKSNEVLLFGRKLTAQEAYDRGLVTEIFPDATFRQDVQNKLDEFATLPKQSMRLSKTLIRSAEREKLHQVNKDECELLVERWTSEECIQAIMDFFAKKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <name evidence="4" type="primary">LOC110980050</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034020449" evidence="2">
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            <begin position="38"/>
            <end position="157"/>
        </location>
    </feature>
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        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022092033.1"/>
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    </evidence>
    <sequence length="157" mass="17281" checksum="17E4748ABB2523B0" modified="2022-01-19" version="1">MIDLNPCLASSSTWRIMDVRLFLGAILLLTPLDMCHGNRDNQILKQARFEDPKSRTVFHREVAADTYADHDDRLRVRRDTADTGQPAGVGFPLNDGLPPPGGQFPPFAPNGDPSTMAPSVDVTPSQTSADNASPLFCASYVKILICFISWYFLQKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHE6</accession>
    <name>A0A8B7YHE6_ACAPL</name>
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        <submittedName>
            <fullName evidence="6 7 8">Coiled-coil domain-containing protein 166-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="6 7 8" type="primary">LOC110980367</name>
    </gene>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
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            <taxon>Valvatacea</taxon>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF4515"/>
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        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF0">
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    </dbReference>
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    </dbReference>
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            <begin position="74"/>
            <end position="263"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="214"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022092672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022092674.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="34629" checksum="5296E594EBB8E14E" modified="2022-01-19" version="1">MPPKKGKGKKGKKTKKADGEEDFEAPEPTEKENLLKAELDSLTEQLASIKKKVEELRKENEWLQQEAHQTRVESHEYMSYMSKKAHKRQTTIVTLSDQNQQEIRMINEQKEQMLEEYEEKKRVLRDSLMEKEAELAKTRKELDDLEEYKRLQEEQVRRIRDLEKEVLRMRGKHTETIQKLKSQFLKEKREYQGESEAKIQEVGKQANREAMHCLQEHTTRIKSENRELRQELLKLIQKSRALNEHKAQLEEQRKELLREQQYAADLKRLHTTRQHKVLKAFEMLDEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YI18</accession>
    <name>A0A8B7YI18_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein LOC110979606</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
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            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
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            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091266.1">
        <property type="nucleotide sequence ID" value="XM_022235574.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="aplc:110979606"/>
    <dbReference type="OMA" id="YCANIEL"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047002">
        <property type="entry name" value="Tcp10_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601:SF1">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46601">
        <property type="entry name" value="ULP_PROTEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="844"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091266.1"/>
        </source>
    </evidence>
    <sequence length="1018" mass="116636" checksum="EC90150B43C1CD4E" modified="2022-01-19" version="1">MPRKKSSPKPSTPFQLRLRSFKTYQSNADQHDGSINSKKPHWRQQRKSDPKQYKALLQCEAVEARVRRAEKMEDLNLPGNEAKKREYLARNAKRQREYRAKKKLQREAEEKKKQADKSKKPVKRTRAEMDKEAKRKEIQAAKKREQRARLSDQKKQQILDRRRQKRREEKEECIRQQQMIQEQEREILEAQAERKRLEEEEKRLAEEEKRLQAAWQQLEDMGQHEERSQDARRQSLKRARSSLSQDPKIYAETVEDLVQRASPRKKRLLHEKGITTDVATKIIYTTVSQKMSSLRKSRKKKDGELKRIFAPALQIAKRYRCQKRVCEKLKTTAKTLKLPSFKPHARLLPNKTKQTIQRCYEENSITLPDKKLXSKKTKKATGFLTMTIRALHGKFQKDNPEMKVCLSKFADLKPAHIKTRHSITYRGCLCEYCANIELKLTAINKLANHSLFENIYQFSDATMCTKKQDQKYHKXACIQRKCKNCGTSQLDVAFQELREKHEGHVNWRKWERESKEEKGKKTHRMVLNTKQGTLEDLLEELKGDAKSISQHLFTAAWQSNEFQQISKSPPDGWIILVCDFAENYSCRFQDEVQSVHWGHESATIHPVISYYRCPNCRKPVTESLIMITADNNHDHHAVHQFTALAINHLKKKLGDIKKIVRFSDGAGSQYKSRSPFLDISYGKEDYCTAFQHEYFGSRHGKGPSDGESGVVKRLATDAVMSGSEVIANARDLYKFIDRTATLPKEGMGEDGDCIHFFRKAFWLESIDRKRDRHARKTVAGTRQFHSILSIKPNVIGVRKLSCFCKACSEDTGSCTNTEYVQPYVITTMVGGAAGAHTTSRENVMPETEPTNPNATTTATNPDATTMATNPDATTEAANPDTTTEATNPDATTDATNPDATTEATNSDSMASNPVPSTDAELDYKVGDYVAVIYDDAWWAGEVTDVNGSMCHVNFLTQKGPNKFCWPTQKDDAWVAKTGIFRRLPCPPAPVTSRYLGFDTQLVKDISLALATYLEKCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIZ5</accession>
    <name>A0A8B7YIZ5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Membrane protein BRI3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Brain protein I3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110980315</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with BRI3BP. Interacts with MGAT1 and IFITM3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BRI3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092587.1">
        <property type="nucleotide sequence ID" value="XM_022236895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIZ5"/>
    <dbReference type="GeneID" id="110980315"/>
    <dbReference type="KEGG" id="aplc:110980315"/>
    <dbReference type="OMA" id="EDDFTCC"/>
    <dbReference type="OrthoDB" id="2564984at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019317">
        <property type="entry name" value="BRI3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551">
        <property type="entry name" value="BRAIN PROTEIN I3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13551:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10164">
        <property type="entry name" value="BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022092587.1"/>
        </source>
    </evidence>
    <sequence length="157" mass="16094" checksum="764D260DB44BAA66" modified="2022-01-19" version="1">MEGGKPGGDMVKPPINPQQASPGYRAEGAPEATGGPPIAGGYPPAGPGGYQSQPGSYPPQGYPAQQGYPPPGQSGYPPQHQGYPAHQQPPTVVTVQQQPATTQVVMTGGCPTCHVGVMTDSYTACGIILAICFFPLGIICCLMMKERTCSNCGATFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLY0</accession>
    <name>A0A8B7YLY0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110981216</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094274.1">
        <property type="nucleotide sequence ID" value="XM_022238582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLY0"/>
    <dbReference type="GeneID" id="110981216"/>
    <dbReference type="KEGG" id="aplc:110981216"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094274.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="27708" checksum="5DFA05DDFDBC68CE" modified="2022-01-19" version="1">MDDTDLSRQYPSTSKKKKQNEEVPEMVGLMEERTQAVRRPDNQDQTTGMFDDKSLYSIARDIHACEWKELAIRLGFTQPEVSHIEADYRHSVVEQICNMLVSWSQKRPGDDVSHLHKALEEVRQGQGGARTSLQPGQPSVDMSENQPSTSQQPTTQGAVSNPLTPECSTSDVQSQAAAAKCKDALKLHYRTTGSYLHQNPYEVDKKRIPDIYTRLQLANAKGDLEDPELTFKESDFEQSVLDIALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN27</accession>
    <name>A0A8B7YN27_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U5 small nuclear ribonucleoprotein TSSC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16" type="primary">LOC110981119</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TSSC4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094065.1">
        <property type="nucleotide sequence ID" value="XM_022238373.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094066.1">
        <property type="nucleotide sequence ID" value="XM_022238374.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094067.1">
        <property type="nucleotide sequence ID" value="XM_022238375.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094068.1">
        <property type="nucleotide sequence ID" value="XM_022238376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN27"/>
    <dbReference type="GeneID" id="110981119"/>
    <dbReference type="KEGG" id="aplc:110981119"/>
    <dbReference type="OMA" id="MCGNSAN"/>
    <dbReference type="OrthoDB" id="1906282at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029338">
        <property type="entry name" value="TSSC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13445">
        <property type="entry name" value="TUMOR SUPPRESSING SUBTRANSFERABLE CANDIDATE 4 TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13445:SF3">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15264">
        <property type="entry name" value="TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="95"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="232"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022094065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022094066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022094067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022094068.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="43065" checksum="6867DDDE50B3D8CD" modified="2022-01-19" version="1">MASESEVSAFEEEGLSSPSTFQLQTSSIRNSANFKSKSANIFGSLETIEKGYSSAVSERGWRAAGVETEEEHDAEEGLIKRGCIFKKPWDALSHKGSTVGSASQLSLRPSSGKPGFDNRAVSPSSRSLDTRPSVKVGSVAKPQAGAQQESSGSSSTTVFRKPDQHLDRRRSFGGRGEGRPIQGLAGRGRRGPPDHVLNPHKYTKYSLEETNMCGNSANRSVALGFLRELRKRKQQVDNPASEDPSASGQFVFKQPRQSTTEDQAEQPFKKTYGNVFKMPEYEVGKGPGLKSKKLKTARLREEHDSACEALVETEREKSFAVSVFCTDHFENEDSLNKGKTKDKGPVQLQGDNSLCHENTDKAEQSKPGVDEESFKSRKGKGKRHFRGRQEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQ23</accession>
    <name>A0A8B7YQ23_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093526.1">
        <property type="nucleotide sequence ID" value="XM_022237834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQ23"/>
    <dbReference type="GeneID" id="110980829"/>
    <dbReference type="KEGG" id="aplc:110980829"/>
    <dbReference type="OMA" id="PTPAICT"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093526.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38358" checksum="890DF2EB1DDC00AB" modified="2022-01-19" version="1">MGLGQSKKSSRESQSDFKPTRASRQNSEHSIKSERFVPPPTSPTPAICTVGPVNEIPNAAEAQPRLNEKPATIFSTGLNNKISYANAIELEKRLNKLQHDGSLSGTSEKNAHCLRQGQQLHQERSLEPLQQQQQEEQQGSQLQQLHQGQHLQQPQQHQSQKSPQQSTQQQQLKQLHQQSVKSQAQTKHQPAQQEAHQFPKQLQQTTLPQKDQQHSQQLVPQQCKKTLIRQQQHQPTLQKQQEKVQQLQQITPACELPQINTTPQHHTQPAQEIERQKQHRRLAQQDQEVQRPSQQQPKLRSKQQKEAARQPAPQLEQPEEQLQVKQQASAATREAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQ94</accession>
    <name>A0A8B7YQ94_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dipeptidyl peptidase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110981392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094625.1">
        <property type="nucleotide sequence ID" value="XM_022238933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQ94"/>
    <dbReference type="GeneID" id="110981392"/>
    <dbReference type="KEGG" id="aplc:110981392"/>
    <dbReference type="OMA" id="MYTTMAM"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF107">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034750159" evidence="6">
        <location>
            <begin position="26"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022094625.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="27909" checksum="B67EF36572D0D0E2" modified="2022-01-19" version="1">MMYTMARVVLVSFALLALGLLRAVADYPYKTMYFDQIIDHFNFKTYGNQTFKQRYLVTEDYWAGGSHPVFFYTGNEADITIFLKNTGFLFDIAPRFGALVIFAEHRYYGESLPFGNHSYTADNVGLLAIEQVLADYATLIQGVKKQLHADNAPVIAFGGSYGAMLSAYLRFKYPNVVRGAISSGGPIYSAAGIGSQTYYFEDVTKVFDSVEASPKCVPTIKEGFSTIASLAQQGQPGLPPSFCHYFADLLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YR67</accession>
    <name>A0A8B7YR67_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18 19">TNF receptor-associated factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18 19 20 21" type="primary">LOC110981046</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022093905.1">
        <property type="nucleotide sequence ID" value="XM_022238213.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093906.1">
        <property type="nucleotide sequence ID" value="XM_022238214.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093907.1">
        <property type="nucleotide sequence ID" value="XM_022238215.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093908.1">
        <property type="nucleotide sequence ID" value="XM_022238216.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093909.1">
        <property type="nucleotide sequence ID" value="XM_022238217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YR67"/>
    <dbReference type="GeneID" id="110981046"/>
    <dbReference type="KEGG" id="aplc:110981046"/>
    <dbReference type="OMA" id="GHRYCDS"/>
    <dbReference type="OrthoDB" id="6499288at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000001">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000189">
        <property type="entry name" value="TNF receptor-associated factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012227">
        <property type="entry name" value="TNF_rcpt-assoc_TRAF_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049342">
        <property type="entry name" value="TRAF1-6_MATH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049441">
        <property type="entry name" value="TRAF2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF138">
        <property type="entry name" value="RE66324P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21355">
        <property type="entry name" value="TRAF-mep_MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21341">
        <property type="entry name" value="TRAF2_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015614">
        <property type="entry name" value="TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="15">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="15">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="14">
        <location>
            <begin position="433"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="11">
        <location>
            <begin position="110"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="11">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="318"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022093905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022093906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022093907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022093908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022093909.1"/>
        </source>
    </evidence>
    <sequence length="586" mass="66265" checksum="CDB423A5FE6AA1F3" modified="2022-01-19" version="1">MAGFPKEIFQEPSFAERFLCYICLMVYRDAVQNPCGHRYCDSCIKEKIRRESGAEHRCPACPENSAEGILNEEEIYPDFVARKEIKNAPVKCINEGCTWTGKLQEYSQDHETSCPVERIKCLKSGCGKTLRRADLAHHLEKECPMRVIECRYCKKQLPYKEAKKHTTECPDAPVTCGCGKRVARSQMEKHLHPETGDCAKRKINCIFSPLGCNVKLVAGGLEDHMSKSLVDHGRRIVDTISSLVSVSKGKDSGAQRLDNETEGLSQVKKYSALSEAELEDLADLLKEHMVVKADDATESKMRKANAGCADAKAPQNEITRINKDVKKVKADLDRAIAKLEREVGKKIEDISAMIAVLDHRTETFQQVLAVLSNELEAVHAKTMALEKQNAYLKEFTEKQEKRLHSQDQMLTLKNIALAEQELRIQALEAVSYDGVLLWRISEYKRRRQDAVSGKTTSFYSPVFYTSRHGYKMSARIYLNGDGMGKHSHLSLFFVVMRGRHDALLPWPFQQKVTFMLLDQNNRDHIVDAFRPDPSSSSFRKPNSDMNIASGCPLFVTQELLNASDNYVKDDTMFIKVIVDTTGLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSC5</accession>
    <name>A0A8B7YSC5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Aquaporin-10-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13 14" type="primary">LOC110981886</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095583.1">
        <property type="nucleotide sequence ID" value="XM_022239891.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095592.1">
        <property type="nucleotide sequence ID" value="XM_022239900.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095600.1">
        <property type="nucleotide sequence ID" value="XM_022239908.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095607.1">
        <property type="nucleotide sequence ID" value="XM_022239915.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095617.1">
        <property type="nucleotide sequence ID" value="XM_022239925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSC5"/>
    <dbReference type="GeneID" id="110981886"/>
    <dbReference type="KEGG" id="aplc:110981886"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022095583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022095592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022095600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022095607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022095617.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="33214" checksum="18BAB4F132350B0C" modified="2022-01-19" version="1">MGLPLVPKRARNCITVKNEIVRGMLAEMAGIFVLVLFVDGGLAAGIVSGWISGTPVSTAVTSGMGVAFGIYTGVAVSGGHVNPSITVGLASVGKFPWRRVPLWILAQLVGALCGASVVFAIYYQGINALDGGNRTVFGDTGTGGIFCTYPQEYFGMGPGFVEQIINTGLLLHCTLMFFDEKNGKPTKGMEPFFVGLSVAMIILAWGHNAGSPMNPARDFAGRFLTWIAGYGSEVWVPRGVHWWWIPTFVPPLGGIVGANFYYLFVELHHPSDSEVVADHGNSELRQIQNEDVKLVGKSSYIKVATEPISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YU28</accession>
    <name>A0A8B7YU28_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 25 member 46-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982102</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095970.1">
        <property type="nucleotide sequence ID" value="XM_022240278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YU28"/>
    <dbReference type="GeneID" id="110982102"/>
    <dbReference type="KEGG" id="aplc:110982102"/>
    <dbReference type="CTD" id="91137"/>
    <dbReference type="OMA" id="RQCQVNH"/>
    <dbReference type="OrthoDB" id="2403262at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090149">
        <property type="term" value="P:mitochondrial membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039158">
        <property type="entry name" value="SLC25A46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252:SF2">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN SLC25A46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21252">
        <property type="entry name" value="TB1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="273"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022095970.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="42775" checksum="2A6C7537EF8F83D3" modified="2022-01-19" version="1">MLSDKMAHRDIFGGNEERAVRPKTQMSGAQEKLVTEMENAAPKQEQTEIIQRFAGLGLGIATLLTENVLSHPFIVFRRQCQVNHHAYRYHLQPFSVVQVIVNLQRHQGIATMWKGLGSAFVVQGIGLGSETVISEVSPLAKEIHVYSTIKQLCGHLTLKAISAAITMPFVSASLVEIVQSDIASERPGVFDCIKEGLYRLLGWGVPQTSNLLPMYTLLLPTVLHSLLKYILSSIVQFVLLQVMRRAREAGHPTDRPEGEPLPIPRSVMEEYFPELLAKFAGNLFADALLYPLETVTVRLHLQGTRTIIDNTDHGYGVIPVSTRYEGMLDCWTAIMADEGTSGLYKGFGALLLQYALHATILKVIQVIFTKLAEDFSIGVKKDAPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUS5</accession>
    <name>A0A8B7YUS5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110981654</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022095081.1">
        <property type="nucleotide sequence ID" value="XM_022239389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUS5"/>
    <dbReference type="GeneID" id="110981654"/>
    <dbReference type="KEGG" id="aplc:110981654"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022095081.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38834" checksum="2784EABED5ADDCFD" modified="2022-01-19" version="1">MATLRNKVEDEAFVTLTTNDSYGYGALVLGQSLRDVGTTRQLVVMVTKQVSQPMRRQLSFIYDVIQQVDPFDSQDAAHLAMLTRPELGITFTKIHCWTLTHFKKCVFLDADCLVLQNVDDLFDREEFSAAPDVGWPDIFNSGVFVFCPSEETYQGLLQCAVTQGSFDGGDQGLLNTYFSNWATLDIKYHLPFVYNMTSAISYTYRPALERFGKEIRIVHFIGTAKPWLYVYYPSTNWLAPPESGDSGHDIEYVRKWWDIFLTKIRPNIEEEQGIDLSGKFGKLRLEVSPLGSPTGEGSSSEASRQQDWEKGQIDYLGKDSFDNIAKHMAEVEKTGAKPKVPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVL5</accession>
    <name>A0A8B7YVL5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097359.1">
        <property type="nucleotide sequence ID" value="XM_022241667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVL5"/>
    <dbReference type="GeneID" id="110982898"/>
    <dbReference type="KEGG" id="aplc:110982898"/>
    <dbReference type="OMA" id="PTIWFLE"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022097359.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="40172" checksum="8F5B6AF07A6A0EEF" modified="2022-01-19" version="1">MKAKMNFLKALLARGLFAIHGIITIWRVTEVNSEIYYLLVIPVCLVPVEMITTLKFADDGEWKWFCPSVLLYLASVVPGLWLLQFDLYDKRIAYRESMGWTDCSGDFMYNETSLSFDVVGFNLVVPVTLSDEDWAVTLEQVLIILLILGRWLLPKGSLTRDQLSQLLLVYIAMGADILEFFGESLGEETVICNRALITVILLIWSWSLGQFTLVRTSVSAAADQPAAKRRRKSVVSGVFGGCCGSEIWTLCIAIVMQDGPFLIVRLYLIIVSGTVNQLMLFFTVKNVVIISLQLYRIAILRFPGLCPGVQTDPDVEEGVPEAEPEGRDNEGLEVDDEGQVEEKENKDEQKEHVIGTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWL3</accession>
    <name>A0A8B7YWL3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metabotropic glutamate receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110983089</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022097709.1">
        <property type="nucleotide sequence ID" value="XM_022242017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWL3"/>
    <dbReference type="GeneID" id="110983089"/>
    <dbReference type="KEGG" id="aplc:110983089"/>
    <dbReference type="OMA" id="CITSEMI"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034451342" evidence="11">
        <location>
            <begin position="20"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="667"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="506"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022097709.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="84456" checksum="3AB2E52EAEA35A90" modified="2022-01-19" version="1">MALFVGLMMLVPTSKPAFAGTIPSAAHASVTRPGDVILGASFPIHRWSSGAPCSAGLYSWGIELSAIMMFAIEQINDREDLLPNVTIGYDIRDNCYSETLSLWTAFSLASTSERPQEDVQFPNISPPDNGSLLCIIGTQTSATTIPTAQAASLYSIPVISPFATSNELSDKRRFPYFLRTVPPDSLQASAIADILLRFEWKYIGLYFQLNTYGIHGAQSLLDLAEKYGICVAFSVAVRHQAKATELLDAVGSDAWALPSHLKRQGVDVSLLQGSLFVQISYTRIPGFDYDRFIQIVESSTPWLVEWKAEHNCSDLSECPIAINTNDNVVVDAVYAFSYALHNMLHDRCSNGTNCNSIQTLSGQDLLQHLLNVRFEGLAGNYSFDSNGDPSGNYKILNFQIVDSTVRAIEVGRWSASAVDPLELNVSAVRWPETRGKPVSICREDCQSGFIEVPLEKKCCFGCQRCPDEAIVIDQECRRCPVDEWPDKKFEVCQPVIPTPPSWSEPTVIVIIILSAFGLVLSLLAAFGIYYYRRHVLIKAASRELSSINILGLTLAFLAPFPLLAQVTDASCRVSEIIITVCFTLTYAPTLLKVNRIYRIFDTGKKSNKRPRFVGPRPQLIPPTGYIEAYCAFGFGSLVSALFNLLLVLACCYYAFKARRVPSNYNESKFIAISVYSTLVFGMAAVPVYITATTVLQKVATLCVAILLNAVLTLLCVYLPKLYAIRFQVDVQLCEWRSSAVAPADTGSATSAARSGIQPTSILPTVHLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWT5</accession>
    <name>A0A8B7YWT5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110981981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110981981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095751.1">
        <property type="nucleotide sequence ID" value="XM_022240059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWT5"/>
    <dbReference type="GeneID" id="110981981"/>
    <dbReference type="KEGG" id="aplc:110981981"/>
    <dbReference type="OMA" id="DSICEYN"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF165">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095751.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="26670" checksum="56FF67F92492EB6C" modified="2022-01-19" version="1">MNTNYPPPAYVAQPSGQQQLVMTQPAPSVVVNQSREGSWKTITSTGITQVVLGSLTIIFGIVNQTALKNYYRNDIGSPIWCGLLFYVVAGILGIVSGKKRSRGVAIAYMVMSILASLSAICVIGFSAAGLTFVNGYYCRYHYFYTDVCDLKKAFIGVYATLILLAVVEFVISIIGASMTCSPLCATTPVTHTVIQYQVPQQMMVAGQPQGTVVYNTGQPIGAYQVQQGQYPQAPPTDQHQYQELAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXQ2</accession>
    <name>A0A8B7YXQ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="27">Polycystic kidney disease protein 1-like 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC110983287</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098113.1">
        <property type="nucleotide sequence ID" value="XM_022242421.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983287"/>
    <dbReference type="KEGG" id="aplc:110983287"/>
    <dbReference type="OMA" id="MIVQGKL"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01752">
        <property type="entry name" value="PLAT_polycystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000008">
        <property type="entry name" value="Polycystic kidney disease 1-like 2, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042060">
        <property type="entry name" value="PLAT_polycystin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034596762" evidence="19">
        <location>
            <begin position="25"/>
            <end position="3125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2028"/>
            <end position="2047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2235"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2276"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2506"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2541"/>
            <end position="2571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2631"/>
            <end position="2652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2874"/>
            <end position="2894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2914"/>
            <end position="2932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2963"/>
            <end position="2983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="2995"/>
            <end position="3023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="3029"/>
            <end position="3048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="3055"/>
            <end position="3083"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="24">
        <location>
            <begin position="590"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="678"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="733"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="21">
        <location>
            <begin position="948"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="REJ" evidence="25">
        <location>
            <begin position="1019"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="23">
        <location>
            <begin position="1840"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="22">
        <location>
            <begin position="2072"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2308"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2352"/>
            <end position="2397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2317"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2352"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2383"/>
            <end position="2397"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="2723"/>
            <end position="2736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022098113.1"/>
        </source>
    </evidence>
    <sequence length="3125" mass="346192" checksum="556644EBFCE3C926" modified="2022-01-19" version="1">MMFRTHLSTFLILHILSTLKQGLALDLRGTRVITSQSSDAGRYAGASSAVDRKLKTISHTGWKDPSDRVNPWWKVDLGAVYCLRKITLVNRIRDVRVIARRLKGNVIRAGMSANHLLNREIGRVREEQAISGAVLDFTPDPYVNARYVSVDIPASGSNIIVQLTEFMVEEVSMDTVDTPSTALSLTGSQSDQSSTHEENGDSWDSARAVDGLSLYEGTSCSRTEFQQNPWWRMDLTSAQCIRKIAVRNMDDIFVYTRLNLYGAVVRAGLSATPTENAMCGSPVTLYQSLINDWIEFTCEPSRLARYVSVDAPGNLTLILCEVMIWPCDLPPTAALNLTGKLANQSSTMSGRDARRAFDGLPEEPFCSITNYEENPWWRVDLESNNCLGKIRIRNTGSSAEPNLQDAMVQAGLSEVHTDNIMCGTPVTRSQAIINDWLEFTCDPPVLARYVSVAIPGGVSLKLCEVTVSTCDFQQAVNAVDITLVANPALLGETGDNSSSITAYRGAGDITNAVTFGRQLATGETSQELPSGSLVVADPSTGCAATLALRLPEEGGLNRTGVFYSEALNNNVITRIQIVILSKGNNIHLRPVQRTQTASTGDSVMLQMRNVNSPNTNYRWRHNGNDVIASWNNLLDVSVPNVIMANEGLYSCFASDHEDEQLDGIMRLIVRGCPSGLWDPPSCLKTCRQCYNGGVCHDKSGTCVCAPGFSGDSCEQVHGRHVFGKNGDQRCSDSGDRHHDACRGHLFCLPDPYGCSCAAGYTGLDCMQECDDGTFGADCKQTCHCASGGTCLKDTGECSSGCDTLYFGSNCQCSTQNSVLGLQVTSGDPHQLFVSWQPDPCASGYELVTRDECTGEILFQESLPETTYHFITGLESPFNCRLFIRPVYPDGMLGTLRVLLQESNTKQESCISWSLEDAVLQMDVAVEGSEDAGVFSAPGDLIFFTGQLIVLNTSLSGSTVSVDYRWYLASNEMVTHSPSITWSFSEAGKFTVSVIASDGISSSDAVSRVLNILDLENLPCHPSYVQIAGHRTNASFPLTYPRHVPLSFQGRTDVWCNLTTFRVGLQWTAFRVESRNETEMALSGTIATHLQEIHFPKGLLRYGLHVLQFSAVVTARGGYGYVIGQGSDRVWVRIEPSPPKAIILGGSARSVGYSSSLVLDGSGSFDPDNFQDPIRGLKYAWYCSKGSRQDLESQVVAPACFGNSYRLPFSDSSIRMPANTLAPDEVYTFALTVSLTGRGNSSTSQSITVVAQDPPVLSISCLQNCEEKLSVGERVVLQVTSPTSTVSYVWDVLTRDHVPDETFDWDRLTTTGRNSAYLVIVGGAFDDGDYRERAVRATGYHPDSPSPGFADYTFELNAPPRMGTCSLDPPSGYALQTQFIIDCVDFWDEEGHLMYTVRVPPALERKDEAALQFLDPVLYSGASSTTPSVYLPLGDASKGHLVTIAVEVADIHGASVMFTMTAEVRSPETVNLGDDENTGEILLNLTSGTDSELQGLIDQGDFQTAVQIIGAVGSILDSHDGSAGEGKGPDHIESQKSKELREEIRTSTVNTIATMPVESVVALQQSSYALVAITQDKMEVTQETQLTAATTLVKMGAFLKEHSVERTDCESCQTSIDDAALNLVSGLSNILDAAVASVDELTAVTTTPIDTVSRNDTISRNKTTPIEEDKDDVRAIQKEVKEKSKEVTKATLATISDVQDALIVDKVPGEEPTVIHSPALTLTSQRQEQGTLGRKSIGVTEAQPSGFILPDAAVIGSFMPANYTDAIDTQMVQFATDPFVWSEGSKDVTSEVVGLQLKTVDRQEIKVTDLPVDIQIFVPKRTVTLANNTEVTVNRSATVVISLQVTNPNATVSVLALPSDTSAELSCCLHYQGNESLVNLTEADCYINTTLPGEASKYWLLIHDADRVLKQRYTWMVDPEQLRGAGKYQALCSVQDSAGTSQSRAPVAEPDDTLKVLIGVYSSQCLFWNEEGEEWDGTGCRAGPLSSPEVTQCLCNHLTFFGSSFLVMPNKIDFLADTKLFLTFLDNPVVVTTVVVILALYVVVAVWARRQDKADALKACVITLEDNDPFAHYRYDVTIVTGMRRGAGTTAIVTLTLIGTRGKSRPHVLRDRQRQVLQRSGVDSFLLTTKQSLGEVKAVRIWHDNGGENPEWYVSRITVHDLETDDWWFFLCNSWLAVDIGEGHIDQTFPTATEKELSDFRHLFSTRTVRDLRDGHLWFSIFSRPARSTFTRLQRVSCCLSLLMCVMLTSIMFYGVPTDPAEQVMDFGAFRITFTEIIIGIESSVLAFPINLMIVTIFRYARPPEMRSKPYEIKNSHRPCSSETTSSLSPRTKEETSLPVSLTEKVVLNTDTTNSTDHWNSCSKDTSSDQVIFSTDRTSREPPTDTNGITGSQKWETSSGEMKFSQLTEPAQLISSANENESYSHNEYLHSCLDRLVDDLDLLPHERFLSAEQYLMARQEARDLVLTVMTIRTPSSSPTDRSETDSQSKTAFCKCSFKFLPNGLPHWFVYIGWFLVFSTTLVSSYFTMLYGLKYGKKRSIDWLVSLVVSLFQSVFFIQPLKVLLFAAFVALVMKQWDADDDGSDDIEEREIENAPEVYRKLLRKWKATHYRPPTNAEVNTGRRRKEMERKMFALLREIVGYFFFIWLVLIVAYSQRDRSSYYLTKHVRDVFFSSDEYHSISDFDGFFEWADLTLLRGLYQGDDQTLFLISGVRLRQLRVRPELCHINRSVRGIIDRCTLSYSKDTEDTGLYNNSWSAPLSHLSANGTSLRRQDIWTHQQNVAVGLWGRVASYPGGGYVANLGVNQTEARRSLKDLMAKRWLDEHSKVLVVEWTVYSANTNLFVVVTFLNEITASGGFVKTSHIQAVRLYRNTAQFQLFVLCIEILFSLYAAFYAFTEVRKIHQQRGSYWHDGWNWLEVAIVLTCMAVIAIYIYRHVSTERLLEVFRARPGEFVDFRAAAAVSEAFQYLLGLLLILCPVKFLHLLRLNPRAHLLTSVLSASAIDVGAFAGYIVLFMCAFALLFQLIFGRHLFTYSSIVLALESLFVLFLGEYRYEELFAVNGVTASILIIVFQAVATYLLLNVLIAVLNQNISYVRRHHEPSEDGKIGLLLIYKILSWFGIKHRHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYD0</accession>
    <name>A0A8B7YYD0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">72 kDa type IV collagenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110982266</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096256.1">
        <property type="nucleotide sequence ID" value="XM_022240564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYD0"/>
    <dbReference type="GeneID" id="110982266"/>
    <dbReference type="KEGG" id="aplc:110982266"/>
    <dbReference type="OMA" id="AHAFWPW"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF294">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="16">
        <location>
            <begin position="122"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="301"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="345"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="15">
        <location>
            <begin position="446"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="14">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
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    <sequence length="551" mass="62200" checksum="81E8C6569770733F" modified="2022-01-19" version="1">MMGHFDVSMKDRVHLTVLFLVFIPGSSVLAWEFNTLNDTVPYFEQFGYIAPVEDGQLQDAEVLLDALHRFQDICGVTRTDGKMDEATAACFQRKRCGNRDFEPGSRGSSGRGRKRRYYIPTEAESWQPESTHITYDIVMYSDDLPPSVIDDSIKRAFEVWSNATALSFERRRGGQVDITLSFYPTMEEHGDNMPFDGPGRILAHAFWPWSEDRLKSDVHLDEAETWTARSYSGANLWLVAAHEIGHSLGLGHSVIFGSLMFPFHFGYDPDFTLHEDDINGIQALYGDVVPTQVTDAPDICRVVMDAVMVDGFTYIFKGEYYWKIFNGRPEPGFPRRISERWPGLEGSIDAALTVKNEYVWMPHTGKTYFFKDRHVWRYTLSSLDEGFPKDAAEEFPGFPSDVQKIKGIFEISGNGETYIFIDGGFYVYSWLGFQGPYTLQVFSGVPTNIVGAIQWTDNYIYFFTDDFLYYQCGPWSFTVSRGFPQHAHVDWIGCSSDSADSLRLAGTAETLQHSEGQDLLTGTGSDRSSAQATSTWTFSMIALSSSVIALT</sequence>
</entry>
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    <accession>A0A8B7YYS2</accession>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
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        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
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    <sequence length="909" mass="102101" checksum="5C72431F1175D12A" modified="2022-01-19" version="1">MVLNFVPPANMHAHQASLSDAPANAPSNSSECPAAQSERRNLLFMTELRALFALMQGTKRKYVDPSKAVEILKGAFSTTGGANSQQDVSEFTHKLLEWLEDAFKSDCSRPPSPQAGEEEGVETPRRNPMLDLFYGQFKAEGINEGKVFTNQETFGQYPLQISGYEDLHESIEASMSHREIETVQHAKEKSAQEHWFTRLPQVLIFELSRFHFNQATGRPEKIHNHFTFPQTLYMDRYMECNQGVTRIKRTQVHQIAQQLEVLQGRLERYLNYGSGPKRFPLQDVLQYALEFAHSTSPENSPIRRSVTLSSNNSNIQDVEMSSPPRSLTGSPPASGFSPDYKSQASVPVNDVAMSSPSSLPNSPADLTRSGANPSPKHITDTELDILQGCLRRWRTEVESDVRDLQDKIATLKDLKSNVYQDDNLRNHVYQLHAVLVHEGQASAGHYWAYLLDHRRNVWLKFNDISVSEVNWVDLERESVGGSGNASAYCLMYVDAKRRDLFEGRSLQFKTITIPLIRQWDEMKEKRGTSRAANAATSTNEDKVVYLGERKSTTTGVKKTMTQPRPASPASVYPAERPLSAAVPDSVSASTHCPGSYVASSSSSLSSPSSVSLSLESIRTEQDAEAALDQVCSDELERYRTLLAQEMSPMRDVRLESPVAYYLKNSAPRVIVRRAVLEQFASAKGINIDVRSQALRKIAQRQLDSQTRSRSEEDNYRLWLEDYRVFCMANTYFIQGIQLYFQQEQDGYQEALPHFVHACNMNDKFIGEKPQKAMDFGMLAHFRRQCLLQLNAQCTNQFDSSDDCEALQGLEILNNLVVPCTGILASSSAEEDTAAAEEIRGGWCSYLNRDVSSNLHEKFQDFLSKLLDMSSEPTSIKAPPLCHTQKKENLSQMFTVAMGMIHNSDQPTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZQ7</accession>
    <name>A0A8B7YZQ7_ACAPL</name>
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        <submittedName>
            <fullName evidence="11">Gastrin/cholecystokinin type B receptor-like</fullName>
        </submittedName>
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        <name evidence="11" type="primary">LOC110983687</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
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        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="ECDYSTEROIDS_DOPAMINE RECEPTOR-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022098839.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="44205" checksum="F037AD89AB829198" modified="2022-01-19" version="1">MDNASGLELSTAATDPTAYGSVVRRPDFGVIITAILNIIFYTSVMLLGISGNSLILRVYGSKPQKTSTHVLIRGLAWFDLMACALRIHNIAYHVAALLGRQLPIFFIATTLASTITPYTSVVLTGAIAVERYDCVCRPRRRLLNPRRAKLLVLGSCLGAVAGCIPYAVAKIFPSPTTIKTALEFQLIPYVAVLLVIAVCYGRVYQTIRKHLKISALSSQGLRTNRSADANTTTRRGNNSIGTSINTLAAQISTDTERVSGRLQPSSSSNTLVVAVVAGPSTSTTPTDAAGDLQPIGRDGEHQPAILQPQPAKGISNDPTVSLQRKTTRMLFVTSVVFLITWLPYWLYVAVALHKYNGADIDDNVLVVVYHCASVLHINNVVNPLIYGVSNRRFRKDSLDMLRKLKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0L6</accession>
    <name>A0A8B7Z0L6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neurogenic locus notch homolog protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110983501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098497.1">
        <property type="nucleotide sequence ID" value="XM_022242805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0L6"/>
    <dbReference type="GeneID" id="110983501"/>
    <dbReference type="KEGG" id="aplc:110983501"/>
    <dbReference type="OMA" id="CQNEHAN"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000638">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF4">
        <property type="entry name" value="UNINFLATABLE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="215"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="253"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="291"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="328"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022098497.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="56857" checksum="A76282FA384B73B3" modified="2022-01-19" version="1">MDQCPDEIKAETELDLTDFLVDQSSAVRTGKYWDAHEKVIDGQYNNSNLLGEGGEIYGGSCTITRAQKDPYWGMISHKDYCISKVWILNRGDGYSERLTGAVVRIGTERTANLNNNTACGSPVTAEQAAVPGGTIEFKCSQPIKGNIFIIGIPADNATLQLCELRVWAVPMKQCFPDFDECSSDPCQNGATCVDGINEFSCTCAAGFTGPLCEDDIDGCSSDPCQNGATCVDGINEYKCTCPAGFTGPLCQHDIDECHSNPCLNEGVCVNKVNSFSCKCPPGYNGTLCETDINECNSNPCQNGVCVEGVGSFTCECSTGYEGATCETNIDECVSNPCQNGATCVDGINEVSCTCPEGFTGSVCETDIDECSSNPCQNDAKCVDGINKVSCICAPGFSGELCQNEHANGPPDNMPQLPQGLSPAGVGVEIQTSYMQMNLVTEYCVKKVVVHKSGDCTSNRLTGAVVRGGTSSTSLNNSVCGTPLTAQQAEIRRSTVDFVCDPPMTAKFVTVDIPLLRLTQQPLCEVTIEQATPGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0N3</accession>
    <name>A0A8B7Z0N3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Adhesion G-protein coupled receptor D1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099168.1">
        <property type="nucleotide sequence ID" value="XM_022243476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0N3"/>
    <dbReference type="GeneID" id="110983860"/>
    <dbReference type="KEGG" id="aplc:110983860"/>
    <dbReference type="OMA" id="CVIMLVN"/>
    <dbReference type="OrthoDB" id="8191206at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000058">
        <property type="entry name" value="Adhesion G protein-coupled receptor F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="10">
        <location>
            <begin position="105"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="298"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022099168.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="64132" checksum="7B1A380815A52C64" modified="2022-01-19" version="1">MYTSTANPGSLSISDGVRTSLEEMTEQFCCLEGLVKDLDKHGDDTLQVAVDIATELLLWNGNASWNDVKELSNNGPLSLMDRLDDIAQALGPRLTLGKQIQAHSPVISCSLESNSLGTFILNNWTYQPFHTEEDMISIQGMDLANLGFKGTERISVLGAAYTNLTGLINYNQKGADKFIVADVITATVFGPDGQISVPTTFRRRLSNIQASNSTHPRIPVCAFWDSYLRGRVAGGWSTKGCKTIWEDGQSSMEASNGDYITCHCNHTTNYAILMRIVPYEKPIGISGRASVGISDRILDILTMVGCIVSILALLTALAFFIFFKHSTLDTERILIHCNLMGTLLVAMVVFMISTYFSGGTIPCKIFAGLLHYLYLAVFCWMLVESVHLYRLIVTVYGSERQMAKLYCAIGWGLPILIVGVSAGIKWTHYGLPGKGCWLSTQNGFIWAFVGPACVIMLVNAVVLAMVIRTTVAASKGTSRDTLAKVKAGLRSSLVLLPMLGITWGVGLIGHVSPVFEYTFVILNSFQGFWLVIVCCLLNGEVRQAFHLTIKKMGKFSGTVDAISTTGNEASKQREKESKGNTCLTDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1W8</accession>
    <name>A0A8B7Z1W8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylglycine monooxygenase</fullName>
            <ecNumber evidence="3">1.14.17.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110982914</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O</text>
            <dbReference type="Rhea" id="RHEA:21452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13486"/>
            <dbReference type="Rhea" id="RHEA-COMP:15321"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
            <dbReference type="ChEBI" id="CHEBI:137000"/>
            <dbReference type="ChEBI" id="CHEBI:142768"/>
            <dbReference type="EC" id="1.14.17.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="14">Binds 2 Cu(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.17.3" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022097391.1">
        <property type="nucleotide sequence ID" value="XM_022241699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1W8"/>
    <dbReference type="GeneID" id="110982914"/>
    <dbReference type="KEGG" id="aplc:110982914"/>
    <dbReference type="OMA" id="HTHETEL"/>
    <dbReference type="OrthoDB" id="10044505at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004504">
        <property type="term" value="F:peptidylglycine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000002">
        <property type="entry name" value="Peptidyl-glycine alpha-amidating monooxygenase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.310:FF:000005">
        <property type="entry name" value="Peptidylglycine alpha-hydroxylating monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020611">
        <property type="entry name" value="Cu2_ascorb_mOase_CS-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000720">
        <property type="entry name" value="PHM/PAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10680:SF14">
        <property type="entry name" value="PEPTIDYL-GLYCINE ALPHA-AMIDATING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00790">
        <property type="entry name" value="PAMONOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00084">
        <property type="entry name" value="CU2_MONOOXYGENASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0186">Copper</keyword>
    <keyword evidence="11 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase N-terminal" evidence="17">
        <location>
            <begin position="146"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Copper type II ascorbate-dependent monooxygenase C-terminal" evidence="18">
        <location>
            <begin position="290"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="162"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="314"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600720-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022097391.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="50608" checksum="09F5E88849823155" modified="2022-01-19" version="1">MLRPIGARRKRTVGEQFTQRARMHITTCVPHTDTLTTKEPAQLALVVGDAPTCLTYMYLASLLYSKASHTNGILVLATMADAYFLGRVSLVFVVLVAVSARGLYPGLNYYYALYGDYPEYFDASSSSDVPEEGLPYVDDNGRFEYNLTMPGVRPPKPDTYYCYSMPLSDEVPVFIVGYQPLAQKMTAHHMILFGCAVPGGTDTVWNCGEMAGTGDNPPCLMGEKIQYAWAMDAPPLKLPNDVGFEVGGNTGINYLVLQVHYNNVDKFKDGTQDFSGIGLQMTFRPQDHLAGVYFMVTNDGEIKANTETKLEAACEYQDSSTLYPFAYRVHTHKLGKVVSGYRIRDDNWEEVGKRNPQLPQMFYPVSNPGSTIEKGDTLAMRCTFEGDKDKDTYIGSTTKDEMCNFYIMFYTKKEPMPEFDTCIDYDYHWVDHLKNIPDKQASTLPDPPESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3X9</accession>
    <name>A0A8B7Z3X9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Paired box protein Pax-3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022099667.1">
        <property type="nucleotide sequence ID" value="XM_022243975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3X9"/>
    <dbReference type="GeneID" id="110984142"/>
    <dbReference type="KEGG" id="aplc:110984142"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000057">
        <property type="entry name" value="Short stature homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF543">
        <property type="entry name" value="FI01017P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="169"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="171"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022099667.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="34049" checksum="46648A2E9C8E70B9" modified="2022-01-19" version="1">MNTTASLLPVGADKQTQRLQNCTSRTAKSEMTSPTACRRAPSDFSIAFILGMRSPTPSSRTVERCRIRAPLLTGTGPAWYLTGVPRAGEDDQSRRDSPILCRLHSLRTTFSVDLKRNLQSPPCSVGSRRSCHQNSHRDADSCRSRDISPRLGESAASSETGRDAVDAARKARRNRTTFTTYQLHQLERAFEKAQYPDVFKREDLAIRLGLSEARVQVWFQNRRAKWRKTEKIFSPVSPSSHHNQLYPGDFADYRSADLAIPTEHLPAVAAHNGNNPSWRTTANQDLQHCSLNTLPQYHPPLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4B4</accession>
    <name>A0A8B7Z4B4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tripartite motif containing 13-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110984515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100469.1">
        <property type="nucleotide sequence ID" value="XM_022244777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4B4"/>
    <dbReference type="GeneID" id="110984515"/>
    <dbReference type="KEGG" id="aplc:110984515"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="348"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022100469.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="53257" checksum="E4E59BA3936492D1" modified="2022-01-19" version="1">MAEGGIYRSNLRKFSEEHLQCSICQDLFKNPKTLNCLHSFCEDCLFRCHSSRVIVRNVICPICREETRTPSGTVNSLRSDFKLAGMIEAVGKEDVQAEPTCVKHAGKKCYIFCCTCHELICFSCLRESHCSHNAGEVGETVEELKQSVIERTIQFDKSSEAVATAQETIEKRKQDFNTTLVKIRKDITDRVKEEIARITVAKQCIMDELDHIQKDRTKLFARRSKHLSSIMEDLHQISNDSKLLAKIGNDYDFLKKYQELKAGIFADENYCCTQIIESISPLALEFRPSVKNPWKFNLGVLVGGTTLGGEDDDGDDHGSEDEQAGCEDDQYGEDDSDTDVGNHGDSLGDGEEEDDNADLDDGDFEDADGDEGEDDDGDDHGSEDEQAGCEDDQYGEDDSDTDVGNHGDSLGGGEEEDDNADLDDGDFEDADGDEGGEDGENGDYGGGGDYVDIDDGEDDETHEENYSQDMYKNIKKKPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4H9</accession>
    <name>A0A8B7Z4H9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984554</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100538.1">
        <property type="nucleotide sequence ID" value="XM_022244846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4H9"/>
    <dbReference type="GeneID" id="110984554"/>
    <dbReference type="KEGG" id="aplc:110984554"/>
    <dbReference type="OrthoDB" id="10468451at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100538.1"/>
        </source>
    </evidence>
    <sequence length="311" mass="35360" checksum="1A8CF9DCBDC7AD51" modified="2022-01-19" version="1">MQKRWHTECFERGCSLSLLLTPHTSSCGCCGELDFDLAVFPLQSYKQKMANWCRLVPVVALILLVSAVSFTSGQDMDVTFQLKKKWFGGFLGRLQVNFNKNASFWFFDVTFRRNVFDLRTLGAVAKVGKENHRSYRFADLPWSRIASDGDAMEILFYAKTWRRVRGLRPTITATKAYPQDRCLRCCSYGGLFYRGNINDWTTYQIKPSLLTTENYVFNDHTTIMSVSDVKPPSYGNVLPKLGESSADLVYDSYSELAGGYGAHIFITREPFHYPVPETSDYWIIFQSGGFSSTWTYLSGSTACECDSNNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4Y8</accession>
    <name>A0A8B7Z4Y8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic solute transporter subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110984638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022100698.1">
        <property type="nucleotide sequence ID" value="XM_022245006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4Y8"/>
    <dbReference type="GeneID" id="110984638"/>
    <dbReference type="KEGG" id="aplc:110984638"/>
    <dbReference type="OMA" id="CLPMVIP"/>
    <dbReference type="OrthoDB" id="5832279at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034570618" evidence="6">
        <location>
            <begin position="19"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022100698.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38640" checksum="8ABAA9C4CD2DD2EF" modified="2022-01-19" version="1">MAMLIVVSTLSFLTGVLYVEMACSVVRTMKYGTQRGYTLFILGLAPVFSLTSLTGIYIPKATLVGVWASSVYLSVSLYIFLMLVFTYFGGPDEMVAKLATTTISLAQPPLACCCPCCCRKIRLTSTNLHRLRGAVLQMAVVYPLTYFITAILWADGLYDPSKVDPTSAYLYLSVTMLASTLTAMYALTIINVAADASLAAMYGTFRLRFSLLQFFMIVPSIQGLVITIISQVVWFPCSGVLAPSIRASLLYNMLVVIEMFLLLVIGRCKSLLNDYHRPLLLGPNQDASLSRSQTQHRYAGIPDATSPMLDAEGNKPAFPTHLLDVEKGQGMVVLNGNQTPFSNGPRKEIQTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z658</accession>
    <name>A0A8B7Z658_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Galanin receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110984497</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
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        <property type="nucleotide sequence ID" value="XM_022244745.1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:neuropeptide Y receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
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    <dbReference type="InterPro" id="IPR017452">
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        <property type="entry name" value="NPY_rcpt"/>
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        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
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    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="85"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="123"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="144"/>
            <end position="167"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="187"/>
            <end position="207"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="243"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="279"/>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
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            <begin position="41"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022100437.1"/>
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    <sequence length="365" mass="41575" checksum="06352D7CD528666D" modified="2022-01-19" version="1">MTTESYGDMLRDRGWSAEGSFEDQVWLRAVYGVIAVLGITGNALVMFTVARVPSLRSLTNMFIVSLAMCDFITSVFLIPLHLGFSIPVPDGVAGDIICRLLLSKFPLWTSFVASVLTLTCVTLERYCSIVHPFRYEALFTHRKAIAMIICIWAMAVLMNSYFFYIFYSDGGRCIIQWQSTVWQKFVGVANFCVIYIFPLSLMGFSYWRIMHNLHKSAQTMRQSTSEGRENQLSRDLLRARKKVVKMLLTVVATFAVCWAPNQFLFFSYMCGWNLDFSSWYYHASVLIAFCNSCMNPFIYGFQSKQHRKALRRAFGCSNAVGARALEGASNLSFVHTADVKEFHVNAMRNLPTPRNTEKATQNRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6A1</accession>
    <name>A0A8B7Z6A1_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">Monocarboxylate transporter 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="Proton-linked_MCT"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
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        <property type="entry name" value="MFS_1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="28"/>
            <end position="51"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="139"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100320.1"/>
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    </evidence>
    <sequence length="292" mass="31532" checksum="F6EE3553E852DA72" modified="2022-01-19" version="1">MASGWAQTGDSFAFVVIPPLTELCLTTYGWRGNLLIIGAVCLHLAPCGVLLKRYKHTDEGEPETSPLLTLAKNPPGCKRSSELKPLCENKTTSSTMDLFTNPFYWIAVVISTGTHVTSGLWRIYFVPHAIAKGVALQDAALYVTLAGSTTLILKILHGPIVDRGLMSSRPLLGVAAFIATTGLIIDPWMNSDWQIACCGVMVLPFTGICFNLSDVITKELLGTDQLDNVFGWIGLKSGLVRIALGFVPGWIYDQTGSYDAAFVMIGCMQSLTLIGLAVLVYMSRTGNEGQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7S0</accession>
    <name>A0A8B7Z7S0_ACAPL</name>
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        <submittedName>
            <fullName evidence="15 16">FRAS1-related extracellular matrix protein 1-like</fullName>
        </submittedName>
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    <gene>
        <name evidence="15 16" type="primary">LOC110985173</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Echinodermata</taxon>
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            <taxon>Valvatacea</taxon>
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            <taxon>Acanthasteridae</taxon>
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        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the FRAS1 family.</text>
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        <property type="nucleotide sequence ID" value="XM_022246011.1"/>
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        <property type="nucleotide sequence ID" value="XM_022246012.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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    </dbReference>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038081">
        <property type="entry name" value="CalX-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003644">
        <property type="entry name" value="Calx_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039005">
        <property type="entry name" value="CSPG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045658">
        <property type="entry name" value="FRAS1-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051561">
        <property type="entry name" value="FRAS1_ECM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739:SF11">
        <property type="entry name" value="FRAS1-RELATED EXTRACELLULAR MATRIX PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45739">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16184">
        <property type="entry name" value="Cadherin_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03160">
        <property type="entry name" value="Calx-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19309">
        <property type="entry name" value="Frem_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00237">
        <property type="entry name" value="Calx_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141072">
        <property type="entry name" value="CalX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51854">
        <property type="entry name" value="CSPG"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665671" evidence="11">
        <location>
            <begin position="25"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="266"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="385"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="493"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="614"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="748"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="862"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="980"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="1103"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="13">
        <location>
            <begin position="1106"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="1219"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="1339"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="1452"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="repeat" description="CSPG" evidence="9">
        <location>
            <begin position="1574"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="2427"/>
            <end position="2532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1828"/>
            <end position="2252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2274"/>
            <end position="2378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1846"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1879"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2160"/>
            <end position="2179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2278"/>
            <end position="2292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022101703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022101704.1"/>
        </source>
    </evidence>
    <sequence length="2546" mass="281028" checksum="0D2AC27A8572A079" modified="2022-01-19" version="1">MAALPRPILPALLLTFHLAATSVGQLVLVNQPLEVPIGRTVMLDESVLAFQAPGEDEQCKVEVAVDEPFYQRVGRLEPQVFDCEFFPGTIRYIHSGSPLLDQDIIKLRAYMLTQTDTIIETFYLTVNVTREPYHVVRPMMNIEVDEFNGISDPIDMRILDFDFNRSSEAVSCFVRVDTLASGLPRYGHLIRGEGDDARDVRVLYENCDDFLYLNLHYQHVLPPSPNMDYIQITVELDDPQKYNQPFTERLYLPVDIVPAFENQHPVEAFLAQYILDVDQFILTTITTDVMSGSDDETRANDLIFYVSKPPGPGEGSIVHLDDQSRPIESFRQADLARLNIAYKAPDRSYPSVRLIEIEFVIYDDYFAKSEPITLTVAVHPTQTNAPRVSVNRGLTLLEGQSRPIRPENFEVVDNDNLGMVRIKVVGGPHHGRMLLNNRPMIMFTPRDITAGSVVYRHDDSDTLKDSVELRITDMTHTVHTSFPINILPNDDSAPTLIRNIQIEVNEGQAVRITRFTLLAADKDSNDDFIVYRITNPPIAGEILKKYSADSFGYPVTDFTQRDLFRGMIYYHHLGQEQFMDSFDIVLLDNHIPPNVSPTQVVLVSISPVHDLPPEVSPKATRSLTVLETEIAFITREHLRYTDAESDDADLRYTITTPPYVAATHSLTGAGRIFSTTGVVMPMKDPTIPAVRTFQQRDIDHHTIAYMPPFKEIGPDPREIRFLFSVSDLYGNVVLGQAFDITVLPVNNQPPVIFTNNLMVPEGGILRILPTHFMITDMDTSVNDLVITLMSLPQYGVLVVGNVNLTEGGTFTVADLSSGRVRYVHGGSEVPTDGFKVAVSDGVHTVSRNVIVSVSPVNDQLPEILPGLITSLTIAEGGEVAITSDVLAATDVDTNDLLLHFIVVQHPRRGVVLRNGIIVNRFTQQDVQRGSISYVHMGGETGKVPVQDSVSFVVSDKTIPSSPDLPVHEIQITITPVDNQAPGIVFGNPFFVSEGSKAPLTLDVLSAIDRDSDLNQLTFHIVGQPQWGLVENILPSPGYEKSNAGKPIVFFRYQDIVNGNINYVQLNHSGIEPMADSFILYVSDGEHPSPNVSFIVNIIPVNDEVPVLTVQNFTVYENSFFKLSTDYVTASDADIPMEMLMFSVVKSPKHGSLVDWALPAESRLPIFDFNLNQLLNTLRLTYLHDGSESNSDNFAIRVTDGKHTVRKSIFVTITPVNDEAPEIIKNAGITLDIRESRIISPVILLTTDRDTTADELYYSILTLPRRGVLQRKLPDNTWRDITALSSNFTQEDLDLNLIRYLHTSELGSKGLDRFRFSVTDGVHTTGKQSFRIEITNTKREPLQLINTGIEVLEGEFVIIAPESLAAFDNGNNLAEILFRVNSPPTEGQLEDISRPGVPISSFSQMALVGQRVIYVHKRTDRIRNDNFMFSVTNGYQTRNDTFHIVVIPVDNSLPVLIINEPLVVPEGGFQVIPPSNLEAIDQDTPPHIVTFIIMQPPQFGHLILAGMPITDQFTQHDLNNYDLSYQHAPNLGQTDADCFYFVVTDNTNEGFLIRDSVVTHPVKFTISIDRMDSDPPRLITNEIPIKMESRNGRYAFILSQQTLYAEDQCTADGITFTITREPQHGYLENLATRQRVKGQFTQHEVNDRSIMYIMRENIHVNNDNFTFSVYDCNGNALMGQRFEFRWPLVQFTRSDYMVCETVGTLQINVMRAGFHALSSFVDIEVSDLTAITGQDYSPPRARQLQFDPGVTMATWNVDIIADELEENRERFRLTLTSPVNAVLGEHDRLTVIIKDSKDGACKGENNGMTITDTLPSCCPGQGAIPPEGLPSCCPDQGPGLPYPGPIIPQQNPGIPGEEPLSYPPKPGDGGQPPNYQSVPGPHPLPEGYPPQGAPYGGDFVPGNPDQGFVYPGEGHDFVPGPGVECCPPDLVPGQGDTGHPYPPQPDPRHGSYQPQQPGADFNPRGPLVYPADPGTYPQGSGVYPQNPGGYPANPEVYPQNPALYPQDPSVHPQDSGSDPQYPANHQHGQWNPGFPSSRGQYPAGSHGGGVPPRTYPDGSQPPLTDAQGQPVWPWYSRDREPYYPSQGGDTTSATQGGPYPGPGGPHYQGQEAINPSAHGGPSYHQGDGDPQYPAQAGSVPHYPQGQGWNRQHPPSAGVNHQPSPGDPYYPGDPRQYPYQQAAGRNPYGHSGSQGPNPRFRPSGQTFQSASRAPVYAGQDPNPSPVSSRPQGPGGVANGQSIQSRPGEKVQGQPVEVWTNGSTTIWTLHGIASAPTVVQGHSPSSPSSSGSSSHQLQPFPAVVQGRPGAPAGPGPITRPSGGPVPSGGPAPSLGPVPDGGRSPNHRGVTEAPPAREPVQPREEAIPPDQSLQPPPGCTMTSKDDFLVEEATGALYKCNGNQWVRVEWSHIQADDAANQDAGCREGWHELDGMCYLLATEPETWDSAQRICRESYQGNLVTVSSSKIYNWIRSLVEKHEIWIGLNNKHAVGQWEWISGDPVTFTRWKVGSPAPNTHGNRNCVAQNSRARWIEKKCRNNRQLYMCEKQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9C6</accession>
    <name>A0A8B7Z9C6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110985101</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nudC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101557.1">
        <property type="nucleotide sequence ID" value="XM_022245865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9C6"/>
    <dbReference type="GeneID" id="110985101"/>
    <dbReference type="KEGG" id="aplc:110985101"/>
    <dbReference type="CTD" id="10726"/>
    <dbReference type="OMA" id="NQMEWWS"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032572">
        <property type="entry name" value="NuDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16273">
        <property type="entry name" value="NuDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="16">
        <location>
            <begin position="180"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="64"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022101557.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="39833" checksum="D57C808E368D33AC" modified="2022-01-19" version="1">MADSSEERFDGMLMAMAQQHEGGVQEMINTFFSFLRRKTDFYHGAQKGQAEKHVIDAFKKQQAIATEEKRKREEEMAAARRAKEEREAKKRAEEEAKRKVAAAKEEDEPKIREITDDEASRLQEEIKSKEAAKVNGTAAETEDRTGDTEESSLKKGDNSDEEEEDEQDKGKLKPNEGNGGDYPNYRFTQTLGELEVHVPFEVPFPIKSRDLIVEIDRKRLKVALKGKPPVLEGETFNEIKVEESNWVIEDKKRVVLFLEKINRMEWWSRVVLTDQEINTKKVNPENSKLSDLDGETRGMVEKMMYDQRQKQMGLPTSEDQKKQELLQKFMKQHPEMDFSNAKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAC9</accession>
    <name>A0A8B7ZAC9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CD209 antigen-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102629.1">
        <property type="nucleotide sequence ID" value="XM_022246937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAC9"/>
    <dbReference type="GeneID" id="110985715"/>
    <dbReference type="KEGG" id="aplc:110985715"/>
    <dbReference type="OMA" id="SECTSSW"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034165427" evidence="2">
        <location>
            <begin position="23"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="42"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102629.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18683" checksum="4A0424084556EA34" modified="2022-01-19" version="1">MVLPKRFIFGLISLHLTMRGTAQNEGCVTAIGHACPFGWTQWTGKCYKALNHQMTWFDAKVECDKMDSDLVVPQSKEETDFLLSMKYYFWINCNDLHTDGVWTCQEGSIEVEYRDWNQGEPNNLGQEEDCGSVWGNTKKWNDTPCSLDYSVICTRPAAPVLHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCQ3</accession>
    <name>A0A8B7ZCQ3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Asparagine-linked glycosylation protein 1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Beta-1,4-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">GDP-mannose-dolichol diphosphochitobiose mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110986124</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the first mannose residues to the dolichol-linked oligosaccharide chain, to produce Man1GlcNAc(2)-PP-dolichol core oligosaccharide. Man1GlcNAc(2)-PP-dolichol is a substrate for ALG2, the following enzyme in the biosynthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13865"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="EC" id="2.4.1.142"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022103459.1">
        <property type="nucleotide sequence ID" value="XM_022247767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCQ3"/>
    <dbReference type="GeneID" id="110986124"/>
    <dbReference type="KEGG" id="aplc:110986124"/>
    <dbReference type="OMA" id="CKLIIDW"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03816">
        <property type="entry name" value="GT33_ALG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000096">
        <property type="entry name" value="ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000109">
        <property type="entry name" value="Chitobiosyldiphosphodolichol beta-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="21">
        <location>
            <begin position="289"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022103459.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="54767" checksum="DA21DB960201ACB5" modified="2022-01-19" version="1">MALFSSPNTDFISQGSLILFMEVYLYLQGLYSVMAVTILFLIMGLGYRKTRCGSQACIIVLGDIGRSPRMQYHALSLATANLDVEMVGYGGSKPHEDLLTNEKIKFHLMSIPPNIPNMIPSLFRYVFKVIWQTTQLLWVMLMKLRWPSHILVQNPPAIPTLAVAWLCSRLYGSKFMIDWHNYGYTLLGLTLGEGHILVRFSRWFESVFGGWGDGHLCVTNAMKEDLMKRFGLKKPITLYDRPPKVFKETPLESQHELFSRLAEDYTVFTSSTKSETSTAFTEKTASGEILRKANRPALIISSTSWTPDEDISILLSALQKYDKACEEEANLPAIVCAITGKGQEKKRYQAIIEQMTMKNVHICTPWLIAEDYPRLLGSSDLGVCLHASSSGLDLPMKVVDMFGSGLPVCALKYDCIDELVKHRENGLVFSNADELATQLQELLRGFPEDQQQLQKFKENLQQFQTERWEENWEKTVRPTLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZD41</accession>
    <name>A0A8B7ZD41_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">(S)-2-hydroxy-acid oxidase</fullName>
            <ecNumber evidence="2">1.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110986207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:67940"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:133514"/>
            <dbReference type="ChEBI" id="CHEBI:176689"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2S)-2-hydroxycarboxylate + O2 = a 2-oxocarboxylate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:16789"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:58123"/>
            <dbReference type="EC" id="1.1.3.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:16790"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.15" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022103593.1">
        <property type="nucleotide sequence ID" value="XM_022247901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZD41"/>
    <dbReference type="GeneID" id="110986207"/>
    <dbReference type="KEGG" id="aplc:110986207"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003973">
        <property type="term" value="F:(S)-2-hydroxy-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="103"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="329"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022103593.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="42497" checksum="2BD750DE02975D1D" modified="2022-01-19" version="1">MEEGGDYARISVRKRRVEVRLLTAMVSLPLCVVAFEPYLKESLPDTVWQYFRSGADDEQTMKDNQFAFQRYRLRPRCLRDVSQRITSTSVLGHYIAFPVGVSPVAAHGFAHPDGEIATAKGVCSVGSVMIHSMWSNKRSEDVASTVQPNTPLFHQLNFLRDRSRMKEVVRKAEVAGYRALVVTVDQPIIGNTRPAKESSLVVPSHISFPNALRPDESFCPQTAHELFDDSATWDTISWLKEITSLPIILKGILTAEDAKEAVKHGVAGILVSNHGGRQLDGTLATIDALPEVVNAVRDSSVEVYLDGGVRKGTDVLKALALGARAVFIGRPVIWGLAYDGENGVKKVLEILREEFSLAMALTGCSSVDDINPDMIVRLPHVNNELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDC7</accession>
    <name>A0A8B7ZDC7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SNW domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986252</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103683.1">
        <property type="nucleotide sequence ID" value="XM_022247991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDC7"/>
    <dbReference type="GeneID" id="110986252"/>
    <dbReference type="KEGG" id="aplc:110986252"/>
    <dbReference type="CTD" id="22938"/>
    <dbReference type="OMA" id="YGQRRGW"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="3">
        <location>
            <begin position="170"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022103683.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="60814" checksum="3C29B5DD828B9330" modified="2022-01-19" version="1">MVSLADILPAPKQWGQEEFESDKPQLNIVSISRSTAPPYGRRKGWVPRTPMDFGDGGAYPEIPVAQFPMDMGRTQGKGNSIAKTVDAEGHVKYDALARVGHGKDKVIHSKPQDLVPIQITNENDPDLQKPDEEEIEDTTEKTRQALEKLVQSKISAAMPVRCAEEKAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEVQKDPMEPPKFRTNKKIPRGPPSPPAPVMHSPTRKVTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQNPQINENFPKLAEALYIADRKAREAVEMRATMERKLATKEKEKHEENLRNLAQKAREDRAGIRTQAEADDEARERDKIREDRHRERQRDRNISRAAPERRAKFDKQKERDISEKIALGLPNAGGRADDMQHDHRLYNTSKGLSSGFAGGDDESYNVYSEPWRKDQNMASSLYRPSKNADKDVYGDDLDTLIKQKRFVPDKDFSGTDHSRRRSGPVQFEREEEEDPFGLDKFLKDAKKAGKRPAEGGKSRDHDDHDRSGKRRKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE02</accession>
    <name>A0A8B7ZE02_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110986372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103884.1">
        <property type="nucleotide sequence ID" value="XM_022248192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE02"/>
    <dbReference type="GeneID" id="110986372"/>
    <dbReference type="KEGG" id="aplc:110986372"/>
    <dbReference type="CTD" id="9412"/>
    <dbReference type="OMA" id="DSFPIEA"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022103884.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="17539" checksum="EB3AD155EDB1376A" modified="2022-01-19" version="1">MADRVTQLQDAVNQLAEHFCNSIGVLQQSATPAKFPGFDKQGVIQQPEPAQPQEDYTQLFAQLIARTAKDIDVLIDSLPSEESTPELQQASLRQLETENQEAASKLAEVVERGEALLVRIQEALGDIAEAQLRTQSNRKNKQEKEGQVKREEGDPETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFS1</accession>
    <name>A0A8B7ZFS1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metabotropic glutamate receptor 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110986352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103847.1">
        <property type="nucleotide sequence ID" value="XM_022248155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986352"/>
    <dbReference type="KEGG" id="aplc:110986352"/>
    <dbReference type="OMA" id="VAWTIMH"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000145">
        <property type="entry name" value="Glutamate receptor, metabotropic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1123"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1236"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1290"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1319"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1346"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103847.1"/>
        </source>
    </evidence>
    <sequence length="1418" mass="154598" checksum="AB0B05BD4A3F726D" modified="2022-01-19" version="1">MSLQQGHDMNRKDIVSNLRMTMHISCAGSEMLSSSDVDSLGVEDFINSVYVYAVALSNLIRDTCPDGRVCDALFDVPSEDWIEHLRAVDFVSHVGLRKRVKFDENGDGPAHYSFYQLTEMNGVYQYGQVGGWTSDGGLDLNKDLLKFYGQDGSIVDMPESPCLEKFCGDPVCHYADDRIEFVIEALFDLHGGECGALQENRFTQVEAALFAVRQINRYSDLRMDARMSLTINDICGDTADAGRAALRLVQGWDFDGGFPGQDQQSYLLGMLHSGSSGKAIAESKVLQVADVPLIASSATSPALSDKSMFGNFLRTVPSDIKQAAAMVELLTRLGLTYIQTIYTMGAYGEGGIKALKEAAKEKGICIANSHFIDSDTNFANLLNNILAKPEARTLVLFLIDENAQALFGEMLTRNVDPSQFQIVASDTWGARTDYIPGLENQALGAFTVSPKTSVILEFEEYFLQQTPGTHNGINPFFIEYWTQKFKCNLPGGDTTYDKNCTGSEMLSRNDVNSLGMENIINVVYAYEFSLSNLIGELCPGGGICDALYNVTSQGWLDYLQEVAFISQFGSKKLVSFDENGDGTASYSIYQLQHMNNVYHLQEVGSWDDVIGVSNLTDVIIDPMFSSQCTGLCLECNPRSATNSTFDQDNYFRIPGDLDLPVVLQLSESGDGVTCGDPKPEESLVLESLLYALDKVNSDPSILPGINLGVTVVDSCGNPAVAIWKLVGLLGGFVNLEGTGKPFAVLGPAKSDVAEEIAEIITGLSKLPMVSHGAVSPSLSNNPRVLSTSAPYIEEVAAIIAILNAYNWAYVGVVHSASPYGKANNQEFQVAAWEAGICIGPQHFVNDTTDIQDIMNDFSSDESLNVIVAFVSERHARSLLFADKFELTRRFVWVGTHTWDSLTLVSGLENTAKGMLVVASDSQDLPEIQDYFSNSDSLRAASLRDPYLRDYLQEICPSLSDCQLENQLQESLKELSGEIVPLVNALYVAAHGVNLLHDIKCGSSSDELCKSFYDSSPDEKVDAIRRVTVESGAGGKPFLFNGGSVPAAYSIKNYQYDGQNGQFLVVGEWHNNQLSIRSAGVNLYSPDAEEPQRSPSGCSCGPLLSPEGAYSQQAHVWSWIDHGIWATVVLALSGLCGVFAVLIAILFLSNRQSYVVQSASFSLSAWLLFGIVLMYLLNLAFMFKPNTAICGIRRFGISFVYCMVYAAMFAKSIRANRFARKQPGVDMNFAGSWSQSLLFLAFLLPEIFLIVEWLVLIPPGVSLPSVNSDTCASSSVQTCAISNIDLTIFMMYAYFLVLVTFFSSFGALNSPHAQHEGKSISVSSLFSILILTAWACVLHLADPLYGIPGISIGLTADATIILVLMFLGKVGALTKKEEADGGNKKVRDADVEDRPEKVINVYENAGAVSDEAVQDQTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHV0</accession>
    <name>A0A8B7ZHV0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA ligase</fullName>
            <ecNumber evidence="15">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110986732</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="15"/>
    <dbReference type="RefSeq" id="XP_022104577.1">
        <property type="nucleotide sequence ID" value="XM_022248885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHV0"/>
    <dbReference type="GeneID" id="110986732"/>
    <dbReference type="KEGG" id="aplc:110986732"/>
    <dbReference type="CTD" id="3981"/>
    <dbReference type="OMA" id="EGIMIKH"/>
    <dbReference type="OrthoDB" id="151490at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005958">
        <property type="term" value="C:DNA-dependent protein kinase-DNA ligase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17722">
        <property type="entry name" value="BRCT_DNA_ligase_IV_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000150">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000008">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000027">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000044">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021536">
        <property type="entry name" value="DNA_ligase_IV_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11411">
        <property type="entry name" value="DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="362"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="18">
        <location>
            <begin position="663"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="18">
        <location>
            <begin position="816"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022104577.1"/>
        </source>
    </evidence>
    <sequence length="925" mass="105812" checksum="D2A8FDD5CDE0DA3A" modified="2022-01-19" version="1">MSDAGDLPSTSTADSVTVASRIPFAELAGFLEKVQKKHGTDGKRQMFREFLEKWREFHKQLHKNNLDTKDNFYPVLRLLLPQLERERVAYGIKEHTLAKLYIEILGLAKESTDAKKLLNYRAPTAKQEAGDFASVAYFVLRNRCPEKGSLSIQDVNTCLDGIAASNAAKKKDVVKKNLMHLLRNTSALEQKWLVRMIMKDMKSGLSQVSIFHAFHPDAEDFFNVTNNLSKLCADLRDPSVRMNEVGISVFSAFSPMLGMRANLNQVEKLMEHKPFYIETKLDGERMQLHKEGNDYKYFSRRSHDYSRSFGETPDDGSLTPYITNCFKRNVRNCILDGEMLAYNPDTKTFMTKGENFDIKTLKDDEDLQVCYCVFDILLYNDKKLANLPLHERVEYIKEVFTPVEGRLHIVERREASSKQEVVTALNDAIDNREEGIMIKNPNTTYLPDRRKGSGWLKIKPEYVDNLMDELDLLVVGGFFGKGIRSQMVSHFLLAVAEPPEVPGEHPVKFIAFAKVGSGYTLKELYDFNQRLLPHLKVFKKENPPSFLQFTKEKPDMYVKPQHSFILQVKATEINSSTSYPTGCTLRFPRVEKVREDREWHQCMTTDELENLRQASEGKLATKYAGLEGDEDVPSKKRKVATRTAKPVGVAARFMAADVSEVTKVSEMFAEREFCVINGPPSHSKTELEKKIVEYGGQVVQNPGYETFCVLADKVNLKVRNIISCDIYDVVRTEWLLTCLEEKKCLPWLPSHMIHVSPETKEQFSLLYDRHGDSYTEDVDAEKLKEIFDKVGQEGDYHMLDSEAIAELEQKYFPGESPLGLFRLCKVYMDSTLIISDQSTHIKDCSLDLVAMEMRFYGATVSPKMADDITHVVLDHSDKTRLPSYKKLLRQRRSKFHLVSPEWVHACIEAGKMLSERRFELGLPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIZ6</accession>
    <name>A0A8B7ZIZ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC110987250 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110987250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105514.1">
        <property type="nucleotide sequence ID" value="XM_022249822.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105515.1">
        <property type="nucleotide sequence ID" value="XM_022249823.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105516.1">
        <property type="nucleotide sequence ID" value="XM_022249824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIZ6"/>
    <dbReference type="GeneID" id="110987250"/>
    <dbReference type="KEGG" id="aplc:110987250"/>
    <dbReference type="OMA" id="SPFHRIG"/>
    <dbReference type="OrthoDB" id="195226at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="387"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="658"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
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        <location>
            <begin position="711"/>
            <end position="741"/>
        </location>
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        <location>
            <begin position="742"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
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            <dbReference type="RefSeq" id="XP_022105514.1"/>
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            <dbReference type="RefSeq" id="XP_022105515.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105516.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="90697" checksum="7E4E645EF19B4D5D" modified="2022-01-19" version="1">MSAENLLQMEEGDDDYPLLPLQRGSGTRQSFTQLRQKQRARRVNVGVTEADIMMEEEGYYDDDLEAKYMATFSRRQKRQTMLVLHDALFLVLDFLQFYALLAAISLRWPWPFNWLYPTRFLFLANLDVWEFMKMNDPEVYNSARNNFIDSTLIGFDYRWYTLGWAIFIFVAITLYIILYIAMNYQKRYNLLLQVARLQRAYIILCQVLAMPIGVMMAKLFHCNADDNMDVHNATPCAGGEHLAYVVPSLAIYVGLFIILPIWMIMKIRTQIFSNRSERHEGFLQLKETEFSHGLDFIWAIKLYHLFSSFRLVWAYYRPVMFLFKLVLLASYAALLWLPMWQMIVFLVAICPLFLVILIRRPFRITSFNVYIMINFLCMLILAIMGLMQNLFDTNSVFFQAEYLFSELLAVGAFWAVFTVVWFVYVLLRYYGLLCRGVPLWPEMTSREVNKLSGETQKYMRALLKGRIVLEHALSTCPLFSPVHELSRQIQIINAYCREAEYLHDPIHDTLWDLLDELIEAHTHLSPVSLFSESVKSSIRETAHEFMKLMPAFKKRLAQREYDFILMTPMKRRMLLKMFTLGVFANGKMNKPRPVDQTETVQRLYNPRESVVLQQRGVEGDDGFYEDMYDSLHDLDPSTLRLKQQQQYKARMMRRPILEEMSEDEDVDADADEDSEVEWMRGIPSRAESDLVSSINDRDADDLSDMMAGIPSRPGSISSTRGSSRTHTSSKSRSNSLFSRRSIPSQMSSGGKQRGTAQRSKTPPQRNIAEESMQDAEDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM90</accession>
    <name>A0A8B7ZM90_ACAPL</name>
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        <submittedName>
            <fullName evidence="9">Juxtaposed with another zinc finger protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110987790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106559.1">
        <property type="nucleotide sequence ID" value="XM_022250867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM90"/>
    <dbReference type="GeneID" id="110987790"/>
    <dbReference type="KEGG" id="aplc:110987790"/>
    <dbReference type="CTD" id="221895"/>
    <dbReference type="OMA" id="CLWHGCG"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Juxtaposed with another zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
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        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
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        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
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        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022106559.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41074" checksum="696D652FA92EB756" modified="2022-01-19" version="1">MYTIYCTMYEYSTCTYVRVQRYTTGVHHCMRRFGMRWRPRLVKCQQKSARCLSEMAVFYTNTCKFSGCSLTFSSLGQLIEHIEETHIDSDPQFIEEQEGQQPSAVALSYVIKFVTDAAKHHNETTPTAKKRPKPNASNVASIRSITPSTGSEYDEYDEFGSESDSDNSVTTQEEYTSEVILRTMNPQIGDDKPYQCPVPGCKKRYKNVNGIKYHAKNGHRKENKVKKSYKCRCGKSYKSQQGLRQHVNIQHPPATLTPSASPKSQSQTTTTSTVQTVLTAKQLGLTLQSTGLLMEPTKCTNSGTLTTVGSTAVEPSTPLTPLTPTTPSTGFTLVTLPSHLDATVLATHKLEGTVVSVQQIQPDGSAVSIMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMZ0</accession>
    <name>A0A8B7ZMZ0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC110987654</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106259.1">
        <property type="nucleotide sequence ID" value="XM_022250567.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022250568.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106261.1">
        <property type="nucleotide sequence ID" value="XM_022250569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMZ0"/>
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    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17336">
        <property type="entry name" value="MFS_SLCO_OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF142">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 5A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="619"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="498"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="703"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022106259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022106260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106261.1"/>
        </source>
    </evidence>
    <sequence length="734" mass="79604" checksum="EC553CF4B3E7B690" modified="2022-01-19" version="1">MQHTNEGRSPSESKYRELPTQEQNGNYSIVDDNPDDEAGVRAQCGLGGLRCRILQVLAHPNAYVLCAGLLFVSTVGASGIYVAGVVSTIEKRFQLRSSESGLLMSMNDISSLCGVLFVTHFGGRSHRPRIVGISGLVVALGSFLAALPQFIFDNPTLDELFVNSANQSEGTSGASLYEKDLLCNAKANASPCTVEEIEASGSQFAKTWPIILGQLLSGLGGAAILPLSVTYIDDAVEKTILPIYMALMFLPMAIAPLFGFSISGYCLSLFVDFYKADTSELGISPRDPRWQGAWWLGFIIYGVILCLVSFPFFFFPRKMDKPKSYCCCTGMPDCCKGWIVRARGGRAAMTEIATHQKKLSGKPVMVIKEFLASLRRLLFNPTYMFSLLGYCLLVISFSGFGIFSAKYIQYEFGISPSTAGLLLGFTVMPGSLIGILLGGVLTSRMAGSQRGYAQLTLGIHVLCVLSYCIMLFFGCPNIKIAGLTTQYGTNGAANGNGLDVFSTCNMDCSCERGTYAPVCGSDNVTYVTACFAGCKTVFEEQHNTTIYEGCACINQTAYSYTNESTFDVASKGACAANCDLLIPFVIFLCLATGISSLSFNPTFMMKFRSVLDKDRDLSLGLSSFLSKVLGFIPAPVLLGAIIDTQCLYWQESCDVTGECFLYDRPGLKFAFIGFTAGFRFLAWVFFCISSVFIFKQMKYEPANDKDGRATQNGEDVNGGANNGLKKMSSKEADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZND6</accession>
    <name>A0A8B7ZND6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110987794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022106567.1">
        <property type="nucleotide sequence ID" value="XM_022250875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZND6"/>
    <dbReference type="GeneID" id="110987794"/>
    <dbReference type="KEGG" id="aplc:110987794"/>
    <dbReference type="CTD" id="56965"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01341">
        <property type="entry name" value="ADP_ribosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="9">
        <location>
            <begin position="541"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022106567.1"/>
        </source>
    </evidence>
    <sequence length="777" mass="86910" checksum="22B1E0B1E4F5858A" modified="2022-01-19" version="1">MSWRRELLARDIESVIDVCIRDPACPFKNFEHSKNSFSFVLNVNGELAAYTFNVTEDYPDNSALTCLNFPDKPEIIRERIPVVFTRMASEHWKPVDVCLPDISSIQDKGGGDASALKSHNLMVIDDEQPPHSPSSVYTDGTCDTDDTDYDDMYYMDLDDEAYYCEDDEPDSSTHPLLLHDMEQVRKHFGPDAINGRVFTELRDIDVELNIDVSFLEEEISKAWCISRSEPIVVRLHCSLTKYLDANVPKVEVFQPSKSGHSGICSQLRKIAETVLLQQWKNVSNEKVQSQLKTAAPSPSKSPSRKCSVEDRSLAKLVDLGFGIDDARSALKMSQGLVEEAAYLLVNQPELGCSASADQSNQKKTSKRLFPWQRSSSVNGQTVTPTGTDDLHLIPAATQNGKNAKVIPSLEHGFLVQLYTYLRNRIPTLSEFCVVCDEQHIFQNGAMLKPAVCERELCVFSFQTLGVMQDAAENIASGAEVVDLMVAMVVSSIKSSRRQLIFEPYPMVVDPRNPKELAFTPKKKNYERIQQALDSFISIREMLAAGCSTDVKKRMDGQDMLAYPLLQWIISSNRSHIVKLPEGRQIRFMHTPHQFLLLSSPPAKEATFRKAKMISGSTFAFHGSHIENWHSILRHGLINASGTKHQMHGAVYGKGIYLSPHSSVSFGYSGMGHGIHKQAKKQGAQALPKEPPTNRQNSPSTCRFLQSRNLTCIALCEVVNSRELTKHGHVWVCTNPDLVCTRFFFVYEDGKVGDQAVDTTQEKYTREIIAAMADCSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPB7</accession>
    <name>A0A8B7ZPB7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Degenerin mec-10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110987987</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106897.1">
        <property type="nucleotide sequence ID" value="XM_022251205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPB7"/>
    <dbReference type="GeneID" id="110987987"/>
    <dbReference type="KEGG" id="aplc:110987987"/>
    <dbReference type="OMA" id="MSQAKHN"/>
    <dbReference type="OrthoDB" id="10051479at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000001">
        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 12" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="10 12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022106897.1"/>
        </source>
    </evidence>
    <sequence length="613" mass="68118" checksum="AD49B6A899CE2201" modified="2022-01-19" version="1">MGSGDQKETFLGALNTLLETSSAHGLPNIHRSKSFLSKAAWTLLFFAGVTALTIQVISLVTTYLKFEYTVSLDVRFDRSLNFPAVTVCNINPVRKSKLERASDGFRELFDVNFAPPRPEDQTGAVNPGDNTDMSPGSTAGGTMKQAGQPLTTQGLAGAGMGQGKGQGGSGMPTAGATMPIAIPTGITTEGPETTAGIEYSNSTSSVNNGTTEATILAWEERQTGDFFKKRDDDYLKEQRLISHLANLTETQRMDMGHLLEDMLLDCQWQGYPCSPANFTSFYHYKFGNCYTFNSFRFGESLKTSRPGPLYGLTLELFLEQEEFMPEITEAAGFRLVVHDRDTMPFPEDDGISISPGSKTAITARVVTIERLGNPYGNCTKKHDEPDDGNIFRDRYGVSYSLKACERSCYQKEVISQCGCFDPHYPNTLNDTVYPCDIDNDEAQSCMSDLEEKYKQGTLTCYCFQQCNETTYHTAASSSIWPSDQFQDKLFRDIKDRNNEVREKLKHLPSPKDWVIKNVAKIEVYFQEFNFEYIKQSPAHTIPSLMSDIGGQLGLWLGLSILTVFELFEHCGTFLAVIVSKLCREGGNLKSSSSKVQKIKIFPTEDPGITLQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPX3</accession>
    <name>A0A8B7ZPX3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NACHT, LRR and PYD domains-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106955.1">
        <property type="nucleotide sequence ID" value="XM_022251263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPX3"/>
    <dbReference type="GeneID" id="110988047"/>
    <dbReference type="KEGG" id="aplc:110988047"/>
    <dbReference type="OMA" id="HIDEIYS"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844:SF1">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="127"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106955.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29145" checksum="21E3739B0BC2C799" modified="2022-01-19" version="1">MADQPTQVPATAARPSDCVSKSSEESTSTAAEKTSLAKHYSSLESIEQHRRVIERCAEALRTTYKSTGSYVPMIPWVDDDSKHIDEIYSGLMLETEEGLTDSERRSRVLETYGEIFEVKTKNGDPIHIAILKGEPGRGKSTLVKKMAYDWAVYIRVLQKYKLVFVLKMHALEQGCDVIDAISDQLLPWLTSSDRRVLDLYIQDSSDKVLFLMDGFDELMTSALCESSFGSVFHVLHRKKYTGCSVVVTTRPSHYANLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWQ0</accession>
    <name>A0A8B7ZWQ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box/LRR-repeat protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109190.1">
        <property type="nucleotide sequence ID" value="XM_022253498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWQ0"/>
    <dbReference type="GeneID" id="110989255"/>
    <dbReference type="KEGG" id="aplc:110989255"/>
    <dbReference type="CTD" id="26235"/>
    <dbReference type="OMA" id="CEIHRDK"/>
    <dbReference type="OrthoDB" id="2153609at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22117">
        <property type="entry name" value="F-box_FBXL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="239"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022109190.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36735" checksum="853D24F336ECCB88" modified="2022-01-19" version="1">MGCRASCVGQPKTKMSTTVSQFAKEVIHFSSQYGTDGSVSYVVPNLAGPSTIYPSYGDMTAACVFRTYGPWWESVPSSQPPIGRNGKKPFLGQDFVDLWYAEKVYPTEVRIYETYHPGAVVQIFACEIHRDKAGQIVNDSVRWQLLWSGSPQVSLSDPRIFSPLLRKVRFASNLIRLVLHHQHLRYYTELDAVELVGTLHDDGTDVDAVYAAHMQKLSINSQDDISVSPNMSTDNGCFDMLPGELIQLIFTDLDLPDLCRAAPTCKLFKKHCYDKLQFMELDLQPQWHLVNENTLEGLAERCQHLQKLSLAWCGDWGSLSSESFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX25</accession>
    <name>A0A8B7ZX25_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">D(2) dopamine receptor-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110989699</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109959.1">
        <property type="nucleotide sequence ID" value="XM_022254267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX25"/>
    <dbReference type="GeneID" id="110989699"/>
    <dbReference type="KEGG" id="aplc:110989699"/>
    <dbReference type="OrthoDB" id="5962705at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF233">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="94"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022109959.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="48571" checksum="245D1AE25AB9799F" modified="2022-01-19" version="1">MSRLVKSSTTDTMANLTGALNLSSTGAMVTSWSPYVTDAQADLLNTTDDGITAPPSGNVIVVDETYYPMIVYSFVDKVLVIVVMPIIFTIGVLGNSAVIIAFFRYLYMRTVTNHYLINLAVADLTFLLFSVPQFWVQYLTTPIIGDYTYLPPEFCKISIFLTDSAVIASGLIVILVTFERYIATCWPFRFRRFSTKRRTIWLCALVWFFSLTYKIPSLIFAVKTKNTLIWHVPLENASEGLPQSIEYCEYCHPRNSVQCVRIRKTLTFDQLLLLSVIPITCVLYTLTMIQLQRSAKSAYVTVLEGATSNVLKKQVVRMLIVTIVVYIICITPFRILNLINIYDHVLPPNLIWIFVNIARIMIYTNSAVNPFIYNIMSERYRKAFKDIFIFCWPCCPKKRKMCNNNGSVEIEMKLCRLPSDRRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXN1</accession>
    <name>A0A8B7ZXN1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110989914 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110303.1">
        <property type="nucleotide sequence ID" value="XM_022254611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXN1"/>
    <dbReference type="GeneID" id="110989914"/>
    <dbReference type="KEGG" id="aplc:110989914"/>
    <dbReference type="OMA" id="CICEGIP"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034990815" evidence="2">
        <location>
            <begin position="29"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110303.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="56648" checksum="3E07DCF865347876" modified="2022-01-19" version="1">MAGLPKLRTRGVLLVLFLAGEFFSTSEAGHVLSPHLSENMRRFLCNRRCNGSCQPCRIPRSTRCMLCRQICCSTEPGEDAADGQCYRDTCDAHNFPCEQERARSVISKTPTSQSASPRMVTTSVCTTAPSQTESTASARVSLTLFQEKIAPNSDKNRRRQRAPQRSGNNNSGERRRKDGERIHSEQQPTGPSTASNIGRSAATDTSNPIYEVSLPMDQTQDKNSKYLETESRTSPNTSNIKQPATNDTSNPIYGVPLPMDEIQDGSSRHLEKRPKASPSESNIEQSATNDTLNPIYGVPFPMDQIQGMTFPSLSGDGGTPCRSCGDSANDVMLSPPPPEVEGKEARGGHQYFVLEQESPPSRQPRQNTEAPHGKETIALEGFAPRDGHGTKKAGEDPETTRDDMQSRGLQGNQSDAHSLPKGPYYFTLEPPFGNQDDETSETTSQGESSDTEGYNHVKRQRAHEAQSPNYSHLTPQSEYDHINRFGHMHSTYGDMSQFHGYSMYSHLKSHDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZM0</accession>
    <name>A0A8B7ZZM0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alpha-aminoadipic semialdehyde synthase, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110989169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 1/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109026.1">
        <property type="nucleotide sequence ID" value="XM_022253334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZM0"/>
    <dbReference type="GeneID" id="110989169"/>
    <dbReference type="KEGG" id="aplc:110989169"/>
    <dbReference type="CTD" id="10157"/>
    <dbReference type="OMA" id="TPHVHDI"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00835"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12189">
        <property type="entry name" value="LKR_SDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000087">
        <property type="entry name" value="alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="8">
        <location>
            <begin position="207"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022109026.1"/>
        </source>
    </evidence>
    <sequence length="951" mass="105884" checksum="E665B0029550B9A8" modified="2022-01-19" version="1">MLRANRLKLAQQLLRASASPKQWRHLSSKGDKPVMAIRREDYGSQWERRAPLNPLQVKSFVDNGVKVLVAPSNRRAYTMEDYSKAGAVIQEDLSEASLILGVKQVPIERLLADKTYCFFSHTIKAQSENMPLLDAILEKNVRLIDYEKLVDENGKRLVAFGKFAGIAGMLNILHGIGLRLLALGHHTPFIHIAAAHNYRNTGMAMQAVRDAGYRIALGELPHSIGPLSFVFMGSGNVSQGAQEVIADLPVEYVEAKDLRSAVEKGDHRKVYATVVHRKDHIVRRDGTAFDKDEYDGHPDLYRSTFSEKIAPWASCIINGIFWNIGHPRFLTNMDTKTLLSPEMSPVAPEAPGCPRLPHRLLAICDITADPGGSIEFIEECSSIESPFDLYDANHKHQHFMSQRTRFSGDGVLVCSIDNMPAQLPREATDFFGNLLQPWVPEMLKSDAKKPFEEEKLSRVITDAIIASNGKLTPKFEYIQQLREVTMPKEESPHVVVPSSFGAEKQRVLLMGSGHMAEPIVEYLTRNGGVAVTIASADKPEADALAAKYDGTNSLYLNVARHTDQTEKAVQEHDIVISMLPYKLHPQVAEKCVAYKKNMVTASYASPEMRALQQGALDAGVTLLNEIGLDPGIDHMLAMECFHNAKAEGGKVRFFDSWCGGLPAPEHSENPLRYKFNWSATASVGAIMRDAKYLQNGEEVFIPPGMLMHESNVQEINFLPGFHLEGYFNRDSTNYVFAYGIPTAHTVRRGTLRYKGFCKTVTSFPKLGLVDDKLHPALVDGAPDITWHELMCKVLGCDTQTSTSRLESIIYDRLGQDEERLNAVLQLGLLSDTVVNKQNSLLDTLSTYLSHTLAYENGERDLVIMKHRIGVEWPNKITSTEEISLTVYGDAYGYSAMAKMVGYPTAIAAKMIMDGEILQKGVVLPFSKDIYHLILNRLKAEDIRAASRTVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A085</accession>
    <name>A0A8B8A085_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1</fullName>
            <ecNumber evidence="11">3.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110990403</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol-3'-phosphate) + H2O = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:75163"/>
            <dbReference type="ChEBI" id="CHEBI:78907"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dibutyryl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42584"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82605"/>
            <dbReference type="ChEBI" id="CHEBI:82606"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65221"/>
            <dbReference type="ChEBI" id="CHEBI:78911"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:42309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + H2O = a 1-acyl-2-hexanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78930"/>
            <dbReference type="ChEBI" id="CHEBI:78931"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42321"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022111089.1">
        <property type="nucleotide sequence ID" value="XM_022255397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A085"/>
    <dbReference type="GeneID" id="110990403"/>
    <dbReference type="KEGG" id="aplc:110990403"/>
    <dbReference type="OMA" id="HESACMV"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14524">
        <property type="entry name" value="PTPMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000060">
        <property type="entry name" value="Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042165">
        <property type="entry name" value="PTPMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044596">
        <property type="entry name" value="PTPMT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46712:SF1">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROPHOSPHATASE AND PROTEIN-TYROSINE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022111089.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="22537" checksum="A1EA90DA957AB3DC" modified="2022-01-19" version="1">MGSRVLFYPTLGYNVFMKSVSSREWYDRIDNTVLLGALPLRSKNIAQELVEKENVRGVIAMNEDFELKRFVTTKEEWTKLGVETLQLPTVDFTEAPSIDKLEQGVKFIMDFAEKQESVYVHCKAGRTRSATLVGCYLMHVNKWTPQEAQIFIQTKRHHIIMKDKHFRAMYRYYDKHIKSQRAGHKLDMSPDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A214</accession>
    <name>A0A8B8A214_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990628</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111402.1">
        <property type="nucleotide sequence ID" value="XM_022255710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A214"/>
    <dbReference type="GeneID" id="110990628"/>
    <dbReference type="KEGG" id="aplc:110990628"/>
    <dbReference type="OMA" id="RDEIRYP"/>
    <dbReference type="OrthoDB" id="5985697at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008042">
        <property type="entry name" value="Retrotrans_Pao"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF5">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05380">
        <property type="entry name" value="Peptidase_A17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111402.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="30166" checksum="4565684188400F29" modified="2022-01-19" version="1">MRDEAHCSFVMGKARVTPLKHVTLMRLELAAATVSTRTSEFLRAELSYQKIQEYFWTDSKIVLGYVPNDARRFHVYVANRVQQIRDSSDPNSWQYVDTSCNPADEASRGLMVKQLVEKSCWLTGPEFLQMDGPTVTPKVAAQKLDEADPEVKQAAVLSTCTEATNENQFPDYFEKCRLDRFSTWHRAKRAIANCLRYKTRLRQGKVVNGYKVPVVAVHPPHVSVEEMEEAETEILKSLQLQHFKSEVQALQQVKQRVSSQAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2K8</accession>
    <name>A0A8B8A2K8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein LOC110991094</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110991094</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022111953.1">
        <property type="nucleotide sequence ID" value="XM_022256261.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110991094"/>
    <dbReference type="KEGG" id="aplc:110991094"/>
    <dbReference type="OMA" id="DMEANDQ"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000512">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000358">
        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF2">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="13">
        <location>
            <begin position="632"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="745"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="860"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="888"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="916"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="932"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1071"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1312"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="940"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="962"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1013"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1161"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1224"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1263"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1319"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022111953.1"/>
        </source>
    </evidence>
    <sequence length="1339" mass="145056" checksum="95087CD56327F9E4" modified="2022-01-19" version="1">MMSDSLAAINVDQLSNAVSAVVNGTPGQSHNAGSTSQVQSAMNLQMPASNPVSVPNAVMVQVDRQLLSQLALPPAVSAVEVSTVDSALLQNSGGFQSGNSQQENRMVQSASGPPTTPQSTALTTQMMGQAASTSRQPASSIQNVALMNAVQMLGAPTANVNGAPALTQNTPSNQVVGTQMMIPSILTSMVPAVTTQSISQSSLLGSPLVLARDGGAGTGLANTFMAKQGGEQMLFNIQPEMPRGSNSTNSNNNILQLVPINNGSGGLSNHQQANSNPMINMSIAIHLPSQGNQDNKDPGNGQKQARTIPLSQLMTGQPIPVSQITGPIQMALEQGQDRGSISSGNVLPAPQFNSSVQGVVSASQVTGQVTRSAVQSPMSVPLSQLAVAQAVPVSQIATRLSDCSSQGGSSLPSNSASQHIQIPHSVLQSFPPNSVNAPSFVANTTMQALTTASQITMPTPTPAQAPVVMMGQEMQGKPYWNLQSLEHGSQLTSDLTSSLTTSLTAQALDGPSIAPISKSKAPKQVEMGLGMLSISPDGLVSSMNADDMATLDLGATESIENLTLPLEEEASNIWCIECNHYNPTTCTTHGPPTFIPDAEIPCRAKLTLPNMLKLSESLTNRKNIRCGVIAVENIQQRCQFGPLVGKVINKSDDILEADSNRIWKIFRNGIVSHFIDVSDENQSNWMRYVRLASRTQEQNVVVHQSGGNIYFTTNKQITMGEELRAWYSQDYARWFGVPDKPGSSFHCTQCPMQFLQRRQLSQHLGFKHPDMASRRYKCSLCPRAFVSSTKLQLHMLTHMGLKPYKCSHCGKQFSDPSNLRIHSRIHTEEKRFICDICQKAFRQKIHLISHMTTHTGEKRLKCPYCELTFSTHSTLTQHRHSHDTGKELRCEKCDRKFKTYRILQKHIKTHSSQRNFKCASCSKAFYTRYHAKRHHQKCRGLPEERGKKRDERREEGKDGEKKARRRRGRPARHPRHTSEESTPDPVETCTVTSSTDTRPYKGRNTEHALMGPREGHPGRADREELPQDGTRGLPGESVRMQRGAFGDGPSLDYFDGGGVLSLSNIEAGVSSAELDQLPEQQKYDHRRNKSRRAASLRGCSVSDGTRHDGRPVRLRKKPKRYSPEEDNSPDKRGLSGSGQQTRGRKRGIFNFNIVGTPAPSGETNPTDQRFQRGTSNDSNPQPGNSLETSLFNSSHTLESNILEDCGDARGSPSTSFSELMEGGSLQNASWPTSAGISALDNTPRAVEPSTSDPVGMLPGRIGQSLSATAAPQTSSSVPQTAETDSALQMASSLYATTSSSLATSSVSMQIRRELTSDMEANDQCDDEERAGTVNDHVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2W0</accession>
    <name>A0A8B8A2W0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 8 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110991153</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112058.1">
        <property type="nucleotide sequence ID" value="XM_022256366.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110991153"/>
    <dbReference type="KEGG" id="aplc:110991153"/>
    <dbReference type="CTD" id="23355"/>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16687">
        <property type="entry name" value="RING-H2_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056939">
        <property type="entry name" value="Znf_RING_Vps8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23412">
        <property type="entry name" value="zf_RING_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1252"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022112058.1"/>
        </source>
    </evidence>
    <sequence length="1420" mass="158660" checksum="ABDF974FE9230AE7" modified="2022-01-19" version="1">MAETSESQKGPEMSSAPTDNFTNLDVDLSLDDVTIDDDEFDIPELETAPTLDSILNENDEPFEVDAPSLSLFSQAPDGSTSVSEPNTPSRSPQKLSRKKSVQYPVHGSIIRHVVLKNISSQVMSASDRVQAGSPTAMAISQFIAVGTSHGLILVFDPNQVLKWCLGSTALGTQYGAVSALGINNDCTRLLAGFARGQITMWDLTNGKLLRTITDAHPPGSAVLHIQFSDDPTMAICSDSGGSVFELSFRRVMGMRTCESRCLFSGSRGEMATIAPLHMNTVVQHPMKDMALLAMATLSKIFLVAVRPKLTVLFTKQLKGDPTTLPLLAWQFVVIQSSDVSRVVDPVLASARTDMVYFHQVLYNDEGLVKVLPLQSINLPYSLIALHWFNSKTLVTVDTTERLHLVDVRTEEELEVLDLVDIELVYSSSHFKSLATGGNVSKAMALAGERACYQSIASHKGQVVILGTKSLHVMTTRQWHERIEILVKDDKYKAALALAHSFYNGKAKAVVGLYGNIDTRRQTVAQKILDLLFTFVDVSMKQGPLRGAIHLLEEHFQRVVPVCVDYCQILGRKDILFGPIYDKFQQDSIAKGVFLECLEPYILNDSLTSITPVVMKDFVDHYKTRMMIHNVEACIVHMDIASLDIHQVVSLCWAHGLYDAIIYVYNKGMNDYITPLEDLLQVLGQAVRSGKQLTDQQIKLGNKLLVYISCCLAGRAYPLGDIPSHLAKSVKEGVWKCLTALHTKQANEEEHAFPYLRTLLHFDTREFLNVLALAFEEPEFASQASSYAAGLQSKQRIVDILLQVMVESIEFSPAQVGCLFTFLARQMAKNDNNIIVNRLLFEQVLEFLSNPDDETRHEEREQALLQLVNAGGMEQVDQQKLLRLAEGAKFYRVTELLYEKRRQFDRILLCYLRDPSRKLAVFSYINNVMIESCYTEPEKEAVQNQALENLQDLVAIDSKETAQLVVKMFASSLEEVIDRLADRPRLQYDFLQGVFEYRDATSTALAPKESQYDPYLHEKYIDLMCQFNPSTVHHYIRNVEGYRLEETLQIVRRHKIADATAYLLEMAGDVQGAFGIMLESLSNSIRNLSDSMEAGKGTDKAKDPSVAICSMQAGLVVIIQLCQRSSAKLDEPDREALWFPLLDLMMASQRKLKPSLSDEHFEAFKDLTRHVLNSMMGYIALPAVLQKIMQDPTYSTGKFGEIKELILGMLDTYNYEKTLLRTTNSLLAHDLYWSLHNLTQAVNRGLIPRKEVCFICNRNYVKVSEDDTVVVFSCGHTYHTSCLHTSGCSSMIEGRQHWMCFQCYSTRRTGKARMVNPRKSQHFASVGGEKGSSERGAVKKGGGIAGATSGAAEKVVQLDLEQIASLDMLRKRLEGPSKLGVLCEVIHSYRDQPRSKGAVSSDSLLLSEDFKLRLCPPPSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A5L5</accession>
    <name>A0A8B8A5L5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G1/S-specific cyclin-D2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110991230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112210.1">
        <property type="nucleotide sequence ID" value="XM_022256518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A5L5"/>
    <dbReference type="GeneID" id="110991230"/>
    <dbReference type="KEGG" id="aplc:110991230"/>
    <dbReference type="OMA" id="KEIKPYM"/>
    <dbReference type="OrthoDB" id="306099at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20516">
        <property type="entry name" value="CYCLIN_CCND_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000003">
        <property type="entry name" value="G1/S-specific cyclin-D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="64"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="157"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022112210.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="36049" checksum="CFED957F5D8021C0" modified="2022-01-19" version="1">MAQIELLCCEVEKVRRAYLDPVLLNDRVLRNLLEVEERYTPCSDYFGNQFQTDIKPIMRKMVAQWVFEVCEEQQCEEEVFPLAMNYLDRFLAVQRIKRSEFQLLGAACMFLASKLKDTIPLTAEKLIIYTDNSITLDQLLQFELIVLRKLKWDLSAITPNDFLEQILHRLPISKECAQRLRRHAQTFIALCATEYSFARQMPSIIAASSVGAVAHGSSQMPIPKLMDKLHRITKIETDYLISCQERMESLLSDSLAHPANLDIPEANKHHESEYEKEQPTTPTDVQDVSKLLDQSGRNMAKMAESRLPAPQSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A685</accession>
    <name>A0A8B8A685_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990696</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111486.1">
        <property type="nucleotide sequence ID" value="XM_022255794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A685"/>
    <dbReference type="GeneID" id="110990696"/>
    <dbReference type="KEGG" id="aplc:110990696"/>
    <dbReference type="OrthoDB" id="5952652at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111486.1"/>
        </source>
    </evidence>
    <sequence length="225" mass="26696" checksum="4D5938730800F0DC" modified="2022-01-19" version="1">MGKNLVADFMTYFPVYIWTDTIRNCRKHILRHMKVSNFEDAFRKLKLKRARVSPVNILLNYAYYYEHDRYDWHLDVNNDLEAYNSKHLQPGFEIKPNDTVPDVRVTVHAGRHFLKTPNPLLQGYCTVKRYIGTPPAFCREFENVTNFQLFEFLAERGVSFNHLATWCSPNNGGREDCSRRIEAHYKNVRKYYTLGWYDLDLHRVLAVEKEAAMENITCPKLFDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-05-27" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D6A9C4</accession>
    <name>A0A0D6A9C4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gonad-stimulating substance-like</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Relaxin-like gonad-stimulating peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RGP</name>
        <name evidence="6" type="synonym">LOC110989162</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2015" name="Invertebr. Reprod. Dev." volume="59" first="212" last="217">
            <title>A gonad-stimulating peptide of the crown-of-thorns starfish, Acanthaster planci.</title>
            <authorList>
                <person name="Mita M."/>
                <person name="Ikeda N."/>
                <person name="Haraguchi S."/>
                <person name="Tsutsui K."/>
                <person name="Nakano Y."/>
                <person name="Nakamura M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="3">Radial nerves</tissue>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2020-02" db="EMBL/GenBank/DDBJ databases">
            <title>Handbook of Hormones.</title>
            <authorList>
                <person name="Mita M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="4">Radial nerve cords</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="EMBL" id="LC033566">
        <property type="protein sequence ID" value="BAQ59100.2"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LC521959">
        <property type="protein sequence ID" value="BBZ90166.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109020.1">
        <property type="nucleotide sequence ID" value="XM_022253328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D6A9C4"/>
    <dbReference type="KEGG" id="aplc:110989162"/>
    <dbReference type="OMA" id="DEDFHMA"/>
    <dbReference type="OrthoDB" id="10375937at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044541897" evidence="2">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="BAQ59100.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="BBZ90166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022109020.1"/>
        </source>
    </evidence>
    <sequence length="117" mass="12892" checksum="B2966AFF918FA4D9" modified="2020-06-17" version="2">MANNLRRRFQATCLVLLILQATINTGAVGEKFCDNDFHLAVYQTCSTHKRGDGEPVLSLKDVLTGSRLRGNIKRSFGSTLEDEAFFASRLVKRSEYDGIASYCCIHGCTPSELAVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XEE4</accession>
    <name>A0A8B7XEE4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Per-hexamer repeat protein 5 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079119.1">
        <property type="nucleotide sequence ID" value="XM_022223427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XEE4"/>
    <dbReference type="GeneID" id="110973029"/>
    <dbReference type="KEGG" id="aplc:110973029"/>
    <dbReference type="OMA" id="ESRMTDG"/>
    <dbReference type="OrthoDB" id="10533287at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052258">
        <property type="entry name" value="Diverse_Func_Domain-Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612">
        <property type="entry name" value="FIBROIN HEAVY CHAIN FIB-H LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612:SF20">
        <property type="entry name" value="PER-HEXAMER REPEAT PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034279150" evidence="2">
        <location>
            <begin position="21"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079119.1"/>
        </source>
    </evidence>
    <sequence length="690" mass="70224" checksum="B8BDAD7185915780" modified="2022-01-19" version="1">MALRLRLLTVLSLTLAVACGRQVGLLSKLRASQQSAWSDPGNRKLKISTSNILGVSKQAFPLVKNEVVPSGLAQGPIRTSMQMIPWQMLSNEINYQQVPSQSVGVEPKNRLLVSNHIKQPSLGTLQFHMTGPDADAQPSKVTQDTLDHSLDIESGLGHALVSDLLKYDGSGSDLGKMLVSDLNKDKGSGSGRGNPPISDLHNDDGSGSGLGNPLVSNLYKDDGSGSGLGKALISDLYKNDGSGSGLGNALNSNLYKDGGFGSGLGNALISDMYKDDGSGSGLGNALISDLNKDDGSGSGLDNPVVSKLYKDDGSGSGLGNELISDMYKDDGSGSGLDSPVVSNLYKDDGSGSGLGKALISDLYKNDGSGSGLGNALNSNLYKDGGSGSGLGNALISDMSKDDGSGSGLGNELISDMYKDDGSGSGLDNPVVSKLYKDDGSGSGLGNELISDMYKDDGSGSGLGNPVVSNLYKDDGSGSGLGNALISDMYKEDGSGSGLGNPVVSKLYKDDGSGSGLGNPVVSNLYKDDGSGSGLGNALISDMYKDDGSGSGLDNPVVSDLYKDPGSGSGLGKALISDLYKDDGSGSGLGNPLVSNLYKDDGSGSGLDNPLVSNLYKDNGSASGLLKALISDLYEDNGSGSGLGNPLVSNMYKDGGSGSGFGKALISNIYKDDGSGSGFDNVMVSDLYKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XET6</accession>
    <name>A0A8B7XET6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA-splicing factor CWC22 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110973085</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079258.1">
        <property type="nucleotide sequence ID" value="XM_022223566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XET6"/>
    <dbReference type="GeneID" id="110973085"/>
    <dbReference type="KEGG" id="aplc:110973085"/>
    <dbReference type="OMA" id="HKPTEER"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="737"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="690"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="936"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="691"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="946"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1010"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1112"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1145"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1194"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1225"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022079258.1"/>
        </source>
    </evidence>
    <sequence length="1246" mass="143696" checksum="E7FE3B4CCE67CA19" modified="2022-01-19" version="1">MGVYRNTAREDQPSKKARHQSSSSSSSSSSDTGSSSDSDSSGSESSSSSSSSGGSSDSSSSGSAANQRGEQRRYSKESQRSKAAEKGDHRASVRSKDDEDQEMRNVSRKRIPSPHSPDEPPPDFEPRSPSTPPPATHRSPAKDRGSTRSSHRSPVIKAPDIETSSTGDKSEDELSIGPDDKDMYRDEDTPPQQEPTKKSSRPQAYQDSEDSSSESDDSYSWRAERVKSVLQSRVHKPTEERRRHRSASYEREDFDSRGRFRSVIGTTIKRQSRPDSPESGEITDEETDGDSDRRGERQPGKRVSPERKRGKHSEDSRRIQDRHQDRHSHRDRGRKEPDSDEDYREAERNFRKRRFEKAQEKRSKQDRNKTLQEQSARWRDRQEEPSRKEPDDEQPASKKTKKETIDTPLQSKTGGAYIPPAKLRMMQEQMTDKSSAAYQRLAWEALKKSINGLINKTNVSNISNIIQELLQLNIVRGRGLLARSVIQAQAASPTFTHVIAALVAIVNCKFPQNGELILKRLVINFKKGFRRNDKVMCLSATRFIAHLVNQQVAHEVIALEILTLLLENPTNDSVEVTIGFLKECAVKLSEVSPRGLNAIFDRLRSILHEAQIEQRVQYMVEVIFANRKDGFKDFPAIQEGLDLVEESEQYTHLLTLEENYSPEDLLNIFKEDPEFLANEEKYKAIRKEILGEDSDESGSEGDSDEESDSQDDDEEDEEHQEAEKMEILDQTETNMIALRRTIYLTIQSSLDFEECAHKMLRMDFKPGQEKEVCLMILDCCAQQRTYEKFFGLLAQRFCQLKREYMQQYEMIFPEQYETCHRLDTNKLRNVAKFFAHLLHTDAISWTVLSVIKMNEEDTTSSSRIFVKIMFQELSEYMGLPKMNERLRDPTLQAYFEGLMPRDNPANTRFSINFFTTIGLGGLTDDLREHLKNYQRTIMQQQRPVESDSSSSGSSSSDSSDSSDSSDSSDSSDSSDSSDSSSSESEDDSKHKGMLRTKKPDVRAVRRREKYRTERPTERQNDSRRAGDVRRDRQGNMEYPRNHRGYDPHDPRLEDVADRGPKNRGQRNNNSRRGYDSSDEDDHGRRSNYNNAQRSNQHDGQQERRRVKAQVEMQDRRFDRSPPKSDKKSARKPRGYDRESDEEERDEVRQEKSRKLRTDGRYKMEDKENRRDRESRDGRVQQSRKRADDTDDDMLDIRANSRRERDNDRGYSNEKSSRESSGSKARQREYSDSPDDRVRRERIRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XFQ0</accession>
    <name>A0A8B7XFQ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110973022</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110973022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079081.1">
        <property type="nucleotide sequence ID" value="XM_022223389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XFQ0"/>
    <dbReference type="GeneID" id="110973022"/>
    <dbReference type="KEGG" id="aplc:110973022"/>
    <dbReference type="OMA" id="VKCRWTS"/>
    <dbReference type="OrthoDB" id="10063988at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034885113" evidence="3">
        <location>
            <begin position="19"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="4">
        <location>
            <begin position="525"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022079081.1"/>
        </source>
    </evidence>
    <sequence length="812" mass="91435" checksum="C2BB593FACE506B7" modified="2022-01-19" version="1">MFTCVWLAILLVVGSVLNHPPWLNASAARLGYYEGGTVFWEARNPDNPREITIDFEFNFDSRKHSSTHYQCTEDDIATQKKLRTGGQFRVGDAQPLWADYYCTHLDRRRHAATGVYRMTYTLPSNEATAEISYTECCWIPGIVNNGRDIGNGKGWNLASTININHKDGVSINSPPQGKTFAKYSIMSGCTYSIHIPHDDANNDIVKCRWTSRRKGECNPNALDICGTPYFDEERIKPVASLDKGSCELSFGEVETIPAGTYAFMVMLEDFAPGRSRKPMSKTPVHFLMNVFDYEGECRQPILHVPRICFAHVLGEEFQIKMVATATAPYHRITSIDVQGYPTDTPRRVPGTSADYEITFRFTPTELKTYTICAMASEDQRFISTQSCFTVKVMRTEPAVLGVDRANSIPAKGSQEAEAVVPKWAIKFKRNIQKGVFSPAYVTLRDSNDVVVWRVDATGPNVEVVNGDTLTFPNSHHVFLEYEAEYTISLDEGVVQSNDRKCSVKSKPAEWSFVTKLPAPALNEPECSISSMRFYIPKALVDLGGHGPEIMHLRDPQCTGANYNETHYVFWTSYDLCGTTFERNGTDYTYGNTVYIPDEPYRPVGTEVTRAPHEEIRFTCSIPAKTIKTLPYNPSPGITGYQMFNGRADFLDTLEDTTLRLFNSRFDQPYVEAAPPLDVAFNNRLYFEGEAMCSSYRNCDAFFQSCWATTSENPYNWPRHELVKAGCKEDWTLQIHNSGASNKVRFSVDAFAFLGWRIHDTVFVHCNVFVCPSNDYSSICKRGCVNPSSTISKRAGSRDVMSVVSSPGLYWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGN5</accession>
    <name>A0A8B7XGN5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">EF-hand calcium-binding domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110973418</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079944.1">
        <property type="nucleotide sequence ID" value="XM_022224252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGN5"/>
    <dbReference type="GeneID" id="110973418"/>
    <dbReference type="KEGG" id="aplc:110973418"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF60">
        <property type="entry name" value="CALAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="130"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022079944.1"/>
        </source>
    </evidence>
    <sequence length="197" mass="22963" checksum="B49B658BAFB113D5" modified="2022-01-19" version="1">MAPNLHFNKEEIEALTNMFKALGKANPSRPEKLERTQVREQLHVQFGVTDDIILDRIVRVFDLDSDNYINLSEWLQGLSVFLKGTYEEKKQFCFKVYDLNDDGFITREELFNLLKSSMTKLQTEEDPDEGIKELLEIAIKRMDIDKDGKIGQDDFSQAVDTDILYLEHFGSCLPEPKDVKAFFKVAAKYPPHKERYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHI2</accession>
    <name>A0A8B7XHI2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vesicle transport through interaction with t-SNAREs homolog 1A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110973220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079567.1">
        <property type="nucleotide sequence ID" value="XM_022223875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHI2"/>
    <dbReference type="GeneID" id="110973220"/>
    <dbReference type="KEGG" id="aplc:110973220"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000001">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREs homolog 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Vesicle transport v-SNARE N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022079567.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="27996" checksum="97160A8B00228B48" modified="2022-01-19" version="1">MASAAMEEFEHQFASISAEITTKINKIPQLTGNEKKQLSSSAERQIDEARELLEQMDLEVRTIPSSDRQKYSTRLRSYEAELTRLEKDLRKAKIAFRDGDASREELLGIDDPRNSEDQRARLLDNTERLERSGKKLEAGYRMTIETGTFARFYKKDVTSASTIGEHVLAEELGQGILENLHKDREKIQRSRARLRETDAGVGQSSRVLSGMMRRIIQNRILMVFLAIVFLAIIIIIIYFMAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIC9</accession>
    <name>A0A8B7XIC9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">Matrix metalloproteinase-21-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17 18" type="primary">LOC110973773</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080549.1">
        <property type="nucleotide sequence ID" value="XM_022224857.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080551.1">
        <property type="nucleotide sequence ID" value="XM_022224859.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080552.1">
        <property type="nucleotide sequence ID" value="XM_022224860.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080553.1">
        <property type="nucleotide sequence ID" value="XM_022224861.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080554.1">
        <property type="nucleotide sequence ID" value="XM_022224862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIC9"/>
    <dbReference type="GeneID" id="110973773"/>
    <dbReference type="KEGG" id="aplc:110973773"/>
    <dbReference type="OMA" id="HVNIHIS"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="entry name" value="PGBD-like superfamily/PGBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hemopexin-like_repeat"/>
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    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF294">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665432" evidence="11">
        <location>
            <begin position="26"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="12">
        <location>
            <begin position="385"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="9">
        <location>
            <begin position="554"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="9">
        <location>
            <begin position="610"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="9">
        <location>
            <begin position="673"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="9">
        <location>
            <begin position="730"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="289"/>
            <end position="314"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="339"/>
            <end position="366"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="479"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="482"/>
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        <ligand>
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        <location>
            <position position="502"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
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        <ligand>
            <name>Zn(2+)</name>
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            <position position="512"/>
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            <name>Zn(2+)</name>
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        <location>
            <position position="520"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <note>catalytic</note>
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        <location>
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        <ligand>
            <name>Ca(2+)</name>
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            <name>Ca(2+)</name>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>5</label>
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        <location>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
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            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022080551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022080552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022080553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022080554.1"/>
        </source>
    </evidence>
    <sequence length="786" mass="86544" checksum="723A25649324C290" modified="2022-01-19" version="1">MHEHRSTKVLIACTVLLGCFGLVTSTPVPPTAATPSSAELPSIVASSPTTELLEPDEATELQSTLPPATVQDYDAKKFLQNYGYMPIYNPAKGKWEFLDRSKTSWQDSRAVTAAPSGKSAETMDSGEKSSPKTASKNDSLAQEERVKFEQAIENFQRRYKLDVTGSIDEKTLRFMQQPRCGVPDYASKFDVKTDPKATTKGGAAETTGKLDMSVGGKGTASTAVNNDSGVIDTTLLSKSTGSVTGVGSTVSSPVAKGAIRTQATLKGGASKASEPISISDLLQQTLRPNPSVGEAVSEGPQRPGAPKTKEPISEVVTDSVTAVDEELATTTRPARAVTTLTTATTPHLSKSDLPRSKRSTGDVGNPAAKVRTKRLSYYDTNSSTSSTAITSSRISWKIDSNYYSRHFSADDLRSQLNQAFRRWAEVLPVTFVEMPLGDLLHVNIHISFLNSLNSGDFTFQFASGELARTTRTATNEAIHFNDDVQWTYNSHQGKNLIKVAVHEIGHVLGLFHSDIEQSIMYPVYIPFESTDSNFRVSIDNESLTRAQAIHGVCAGSFDTILDWVRWVGNRKKYNSLFFRGDALWVYENTNNRVKTGDPRTVHDMWASNVPTHLDATLQILSRSSSSDDLYFFKGNKYYQINSATRAVMANPDGTFGRSIAQGWPAKPGFPRIPDNIDTAYYDKRDGNVYFFKGNQVYAYDMQADGCCLDNYPMPISTAYPYRYNMTSGLPGDIDAAYYSIHSRKLFFFKGDVYWENETYNPGLSTVVNKVGPGQQWNQRWNNICDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIM4</accession>
    <name>A0A8B7XIM4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Integrin alpha-9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110973432</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079967.1">
        <property type="nucleotide sequence ID" value="XM_022224275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIM4"/>
    <dbReference type="GeneID" id="110973432"/>
    <dbReference type="KEGG" id="aplc:110973432"/>
    <dbReference type="OMA" id="ICAPRWI"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF134">
        <property type="entry name" value="INTEGRIN ALPHA-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0401">Integrin</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034449578" evidence="13">
        <location>
            <begin position="24"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1051"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="290"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="352"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="12">
        <location>
            <begin position="414"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="15">
        <location>
            <begin position="459"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="16">
        <location>
            <begin position="607"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="17">
        <location>
            <begin position="852"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1096"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1107"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022079967.1"/>
        </source>
    </evidence>
    <sequence length="1121" mass="122214" checksum="114F5F60CE36ECC4" modified="2022-01-19" version="1">MKGLVLAVVALGLIGAAWIPVLAFNVNSEVRDVRTFQGPEGSMFGLTVLGHHSGKGIGDSWVLVGAPNSTSEYQPTLPGPPGALYKCQLPGDGRCTQVLLDNKGNEIYDVSHRRVEDKKDGQFLGVALTRKPGPNGKVVVCGHRWINQDHATRYPNSVDSILYYARGICYSMDSTLQSVEVVRPCILDPSSDWWRCLAGASAEYAVDGQTLMLGAPGAMYNLGSVITVKGDQMNHIGRIWNHRIPNHQYPYLGYSLTSGHFSSPTALEGATGGPRYRDLGTVYIFDLEQASVVRQFIGEPVNSYFGASVEAADLNGDGWSDLLVGAPLYSSSQDEGRVYVYINDGMGNLEMRHKLGGSNAVGARFGFAIESIPGDLNKDGYPDVAIGAPYEDETSGAVYIYHGSISGINPKYSQRIAGKSFNLVSFGAALSGALDLDGNSYPDLIVGAHLNNSVVYLRTKPVIYMQAQMDLSPPTLVLRNASDVSRQPITCTVSFCMTYSGVSVNSSQDVVYTLEADTKVSSILQSRVYFGLSVSTSTVEEMISLVTGAQKCLNHTLTVKSFVQDFLNPITVQLSYRLRDSSDPLAPVLSPSSSSGIQKEIGFARDCGLDDICEADLQFVNYSYSLLSGREDIFLGADSIVYITAKIANVGEEAHRARLVITHPENVVYEAVGTLATTELMPVKCEPVSLEDGSNPYVDCSIGNPLKSNGEVTLQVRMDIGNLAPSQTDLNVSLVLSTSSTELELGDNEALVTIPVTVLADVTVKGAFTPEQLVYRQDKYNLRQYLGDVLAIVQRLRDAQTLSTPADPPVAFNVGRDRPEGAVSITESPLVIGTPKLSDQPDQDRDLEENVETFVNDTEIGPTFVQKLEISNLGPGRVPYASVVNVSIPWRTPKGDWLIFITQVQGRDGVEACNLESLLEEQYQGILTFYNKSSNAKVDRSDRTNQEREKRGTLKTTFDCTSAECVTVQCEIEPLAVRGSSVIEVHARLWKYSFLKSRFGLVTMKTKAVLEVKNPQDLFSQPDGHLPDETTVKITISAQDIETPKLPLPPWVIPVSISVGIFLLILIVTGMAWGGFFQRKKAEKLKQMRQSLIQADQQEEELLQPEGEAKGYPDKSEARYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJD1</accession>
    <name>A0A8B7XJD1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-crystallin 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080237.1">
        <property type="nucleotide sequence ID" value="XM_022224545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJD1"/>
    <dbReference type="GeneID" id="110973615"/>
    <dbReference type="KEGG" id="aplc:110973615"/>
    <dbReference type="OMA" id="THAQEVP"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080237.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23298" checksum="32E4FD0147096E56" modified="2022-01-19" version="1">MPSYKVVYFQGRGYAEPTRMLLALAGQEFEDVRYSREEWSQHKAEAPMQQLPYLEVDGKIIPQSRAMHGFVAREFGFNGANNEETTKIDVINAILEDIRIPLSKIFYEQDEEKKKEGLAKFYAETTPKFFKALEKMLVDNNGGDGFLVGSKISRADIFFYVSMEFLDQNEVKKYPRLVALMERVAKDPKIAAYLAKRPQTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKK2</accession>
    <name>A0A8B7XKK2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110973736</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022080480.1">
        <property type="nucleotide sequence ID" value="XM_022224788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKK2"/>
    <dbReference type="GeneID" id="110973736"/>
    <dbReference type="KEGG" id="aplc:110973736"/>
    <dbReference type="OMA" id="YDFVGHY"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022080480.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="47253" checksum="953772F7EA2797F2" modified="2022-01-19" version="1">MLHSLKSVVLLLTLITISVVVSLYQALFTLNLFRDHSETFTSRQIAGALPKISGKGTHSTERRRGENGELEATTNYRDASWIDNKAEKSKSWLEDRTALELDSYRYLHHPETVNRTYDVWQTQQLRRKVLRETCDSLRDKHRLRKAEVPPSHLLVDDRHRFVFCEVRKVSSIAWRRVLDALASAYPAGHSVGGMGLRRLGTYSAHQRERRLSEYTKFLFVRDPMLRLVSGWRDKFLVGPQRHNYQSSWGAKIRGYSKHRARNNSSSDSVHGAQQLVLSSSAVEDQPVSFTEFVKYLTAGPPRSPLVRDMHWETYNSRCRPCLVRYDFVGHYETLGPDAAAILNALDGRRQGNGNLRFPAGRSDSLSVARQEFPKLASEDVVALAKLYDVDYELFGYSMSRFRNWLQNASTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKT4</accession>
    <name>A0A8B7XKT4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110974234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081419.1">
        <property type="nucleotide sequence ID" value="XM_022225727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKT4"/>
    <dbReference type="GeneID" id="110974234"/>
    <dbReference type="KEGG" id="aplc:110974234"/>
    <dbReference type="CTD" id="10001"/>
    <dbReference type="OMA" id="KKDMKPP"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016820">
        <property type="entry name" value="Mediator_Med6_met/pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023869">
        <property type="entry name" value="Mediator_MED6_meta/pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022081419.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="30231" checksum="FAFEBA60156E819F" modified="2022-01-19" version="1">MATPEKENPLFMSWHNSAWIPHLSRANIMDYFADRSNPFYDRTCNNEIIKMQRVNPEQLKTMTGLEYELLHVQEPILYVIRKQHRHSVEHTTPLANYYIIAGVVYQAPDLCSVLNSRMLTSLHHIESAFEEAQSFSRYSPSKGYWWEFKDKEQEQAEEKQKNQRKKEEAASSMFQRQRVDVLLKELSRKFPPKVIQAKPGEKPIPVEHQNGTVAIKEEIKEEQQQVNSNSVATTGTIGAPNAGAFFSGGMRPPMVKKRKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKZ5</accession>
    <name>A0A8B7XKZ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080806.1">
        <property type="nucleotide sequence ID" value="XM_022225114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKZ5"/>
    <dbReference type="GeneID" id="110973903"/>
    <dbReference type="KEGG" id="aplc:110973903"/>
    <dbReference type="OMA" id="NCKFRCI"/>
    <dbReference type="OrthoDB" id="6143546at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080806.1"/>
        </source>
    </evidence>
    <sequence length="692" mass="77273" checksum="780E01D43BBC3E59" modified="2022-01-19" version="1">MAQSLEVVMLFGPPFAGKTAYYKHHLKRSHERVSAVDLFREDSDLGLRQVILKIVSLLKQGKRVVIDDENWSKSTRLSYVKSISAKVPNCKFRCIKFNTDGPLALHWLQEWSLAKSILSCDERSLDDWARCEARISRWFGDDVTGRRPEIPTAEEGISLQDIQVKLVADDVDYKFEVPALFIEWEGICQQKEDGTNRSLEGTREVLQTWTSCNPWGRIIIISHGSCSDDAISKVPDNWTVISMKQALMDLCQSLPSPVYFYHHSDPKSSPSFATPPQPGTLAFLQRFHHIHLWHRGTLYLYHTMDHADGARAAGVNCLKAAAALQSPSLVCLSQCSAREDPDPILKDIKLIGHSELDQQRSTPRIPLYSDAVASGEKVCFVLESDCRRTLGICFRDRNTLDRYQELYAETATKIMASGTKMVTCIPDNPVINGQRQITDSVDSSQQEAVTSQQPITLTASKPETQQTTRGLPSWMLSQSLKKTKKVDRLIGGESFEDSSLEEPARKKKSDVSPLLSTVYCMSPAELCETAWMILKEDHDLDSSRQADREDSSLSRETQELRTITKDASILVNHSEDSISAESRSDMHTESGGEEARLLDDIFMVSSPGMKPPPRKAKFPKKSQKYSNSSSARPECYAPETVMSVPETAGYTAASIGPKESTIALVGESSTKQIETGTKESRGPDFSFLDDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM92</accession>
    <name>A0A8B7XM92_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Voltage-dependent L-type calcium channel subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110974142</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081221.1">
        <property type="nucleotide sequence ID" value="XM_022225529.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974142"/>
    <dbReference type="KEGG" id="aplc:110974142"/>
    <dbReference type="OMA" id="QFMASAI"/>
    <dbReference type="OrthoDB" id="431720at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000007">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000009">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000107">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000001">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000006">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000010">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000120">
        <property type="entry name" value="Voltage-dependent L-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000063">
        <property type="entry name" value="Voltage-dependent N-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031649">
        <property type="entry name" value="GPHH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005446">
        <property type="entry name" value="VDCC_L_a1su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF1">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE D SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08763">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16905">
        <property type="entry name" value="GPHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01630">
        <property type="entry name" value="LVDCCALPHA1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 17" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4 17" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10 17" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="504"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="696"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="889"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="919"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="962"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1007"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1130"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1211"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1243"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1272"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1340"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1435"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="20">
        <location>
            <begin position="1593"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="450"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="748"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1695"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2209"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="785"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="804"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="828"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1707"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1731"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1763"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1794"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1836"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1885"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1912"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1930"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1979"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1996"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="2235"/>
            <end position="2261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1104"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022081221.1"/>
        </source>
    </evidence>
    <sequence length="2277" mass="256518" checksum="E3D2C5F1DF846359" modified="2022-01-19" version="1">MDKFRTVVHNNVAAATASSGTYVSGSASTPTPTTASPTGLPATTNAPLSSAWRTTLAATTTVSTMNRRRNTYNKKKQHSGTSLRPPRALFCLTLDNPVRRMCISIVEWKPFEYLILLTIFANCFALAIYTPFPHEDTNTTNKNLENVEYIFLFIFTLEAMLKIVAMGFLFHSGAYLRNAWNFLDFIIVIIGVVSTILSHTAQQIAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIVRAMVPLLHIALLVIFVILIYAVIGLELFIGKLHRTCWIVEDGVRRHVEEEPHPCGDRGFNCSELREDAFCDEYWEGPNEGITNFDNIGQAMLTVFQCITMEGWTDVLYNVNYAIESWWPWFYFVTLILLGSFFVLNLILGVLSGEFSKEREKAKARGAFQKFREKKQIEEDLKGYLDWIMQAEDIDPENEIEQHGEPPKHVLWKRLGTLNTKVPKPMSESDSSEKSEELGSTDIPQQSWMQRKKRQMRRWNRRCRRLCRQAVKSQAFYWVVIIMVFLNTIILASEHYRQPKWLMDFQDIGNLLFVVIFTVEMLIKMYSLGLQGYFVSLFNRFDCFVVCSSMVEVVLMYAGVIQPIGISVLRCVRLLRVFKVTRYWASLRNLVASLLNSMRSIASLLLLLFLFILIFALLGMQVFGGRFNFNKTQDKPRSNFDNFWQSLFTVFQILTGEDWNEVMYDGIAAYGGVHSIGIIASSYFIILYIWGNYILLNVFLAIAVDNLADAESLTALEKEREEEKRNKSIRRANEVDLSKQLPPGVDPKGVIRGPKRLQEKRKALNKEAPSSNNHKAIEDGEKQVHIEEDEAKKALKEPGDEDEDEEEEETLTTQSARPRRLSELDLPNKKAPMPKESSLFVLGPENRFRKGCYFVCTHNYFSNVVLLLILISSIMLAAEDPIDKNKTLNFILNCFDYGFTVAFTIEILLKVISFGLVIHKGAFCRNFFNLLDLLVVTVSYISIALQGQGAISAVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIMMVMLLLVFMFACIGVQLFSGKFYSCTDLSKMTEEHCHGNFIEYKDGNYLEPVVKPRVWKLNEFSFNNVGSGMLALFTICTFEGWPQLLYVAIDAASEPDHGPIRNNQLGVAIFFFIYIIVVAFFMVNIFVGFVIVTFQNEGEQEFKNCELDKNQRQCLEFALKARPKKKYIPKNSKQLKVWKIVTSRPFEYLIFVLIMVNTIVLAMKYYDQSDEYSEVLDRVNIVFTAIFLLECILKIIAFKIKNYVRDLWNLFDFVIVVGSIIDIILSEGKASQMDSESRFSINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMLFFVYAVIGMQLFGKIALTTDGPINRNNNFQSFVAALLVLFRSATGEAWQQIMLACASSPEAKCDPFVLEHQPEVGETCGNDFAYIYFLTFYSFCSFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFVRNWAEYDPEATGKIKHLDVVALLRQISPPLGFGKLCPYRIACKRLVSMNMPLNSDGTVMFNATLFALIRTSLKIKTEGNIDKANDELRQVIRKIWKRTSTKMLDQVVPPAGADDDVTVGKFYATFLIQDYFRRFKKRKHDQLKMQGHEQGTVALQAGLRTLQEIGPQIKRAISGNLEDMDDEVSEAVELDEPSHRRSHSLFGNMLNMYHNRRQSAPMANTHPHHSIPLTNNLTVSPSSQHRKLSPANSLNSYSYTPRSRSPYSMSSGGGSFRSSRPPAGNALHVSSPNSAGFSPVGTQRYSPNNVAGRNHRHSSGQSHEATQPLLSEEDHHLDPPYRNGSVHADDQNYGTLGQGRQEMEHNAGDSREPFQDPYREPYRDYSRIPKSILRITRRLREPPPTLTTECYDDEDDDTSSENSHPATSPLLSHEHTPSPSRSCSSGSRSVSASPQTSSLTDFPTATGTSSSRYPGDESSLPGGECGGDGGNSYPAMAGRKVPPLSSARTSGSSLLSCVGKAEPRPASERKTAVPLKLAQAQVMAVAGMTPEGKPRDDGRPSLWLTPPSSPRRVRSSYHTPTPPRGRASGRGGGDSLLPTDNNNASAKEPLALRHSTGEIGTSRDPSTAFFKALTKPRVRQPLIPKGPKAAASQMPENVEGSAESLVAQVLEEEGISPIHDRDLISTVERELAEACNMSQSEMDAAAHRLIQANQQGDTSLPYFDHLGGYELQDYTQRSRSRKRGHSREGGFRTNSKGTSQEEDDLESENTDSENDGEDDHDDDDDDAKPKDSSGDMVYVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN53</accession>
    <name>A0A8B7XN53_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione S-transferase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110974264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081486.1">
        <property type="nucleotide sequence ID" value="XM_022225794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN53"/>
    <dbReference type="GeneID" id="110974264"/>
    <dbReference type="KEGG" id="aplc:110974264"/>
    <dbReference type="OMA" id="MMEVEFA"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022081486.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23292" checksum="B590B216EAEFA9FF" modified="2022-01-19" version="1">MPSYKVVYFDGRGYAEPTRMLLALAGQEFEDIRYSREEWPQHKADAPMQQLPYLEVDGKKIPQSRAMHGFVAREFGLNGANNEETTKIDVIIASLEDIRLPLSRIVFREQDEEKKKELLAKFYAETAPKFFTALEKMLVENGGDGFLVGSKISRADIFFYVVMEFLDQNEVKKYPKLVALMERVAKDPKIAAYLAKRPQTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNC3</accession>
    <name>A0A8B7XNC3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Adducin-related protein C1289.14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC110974765</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldolase class II family. Adducin subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082318.1">
        <property type="nucleotide sequence ID" value="XM_022226626.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082319.1">
        <property type="nucleotide sequence ID" value="XM_022226627.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082320.1">
        <property type="nucleotide sequence ID" value="XM_022226628.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082321.1">
        <property type="nucleotide sequence ID" value="XM_022226629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNC3"/>
    <dbReference type="GeneID" id="110974765"/>
    <dbReference type="KEGG" id="aplc:110974765"/>
    <dbReference type="OMA" id="NPWGLWW"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF21">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022082318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022082319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022082320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022082321.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27782" checksum="1E08A45867510753" modified="2022-01-19" version="1">MMTEAELANRHAREDLAACYRGMDYYGLGEGICNHLSLRAPARSGKGEVMLLVPYGIHWSQMTASSLIGIDMETQEVVEGKGNGEENAVSAHLSIYKAMKDVRCVMHIHPPYATALSCLKEPWLKMIHQTCMRFYGKVGYDLQFGGTVAMGNESTRLADKMAGRQILVMGNHGIMGIGKSAGEVFDNLYYFERAAMIQMLADATGKELAVASNEVAQGVAEYTDNYGDSFKIDHLEALKKVLERKEPNFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNS6</accession>
    <name>A0A8B7XNS6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein PLANT CADMIUM RESISTANCE 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110974861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082463.1">
        <property type="nucleotide sequence ID" value="XM_022226771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNS6"/>
    <dbReference type="GeneID" id="110974861"/>
    <dbReference type="KEGG" id="aplc:110974861"/>
    <dbReference type="OMA" id="LMICCCG"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022082463.1"/>
        </source>
    </evidence>
    <sequence length="111" mass="11830" checksum="69A9D4E161AE9F2D" modified="2022-01-19" version="1">MGEWQHGIFGCFDNIGLCIFTYIVPCYTFGKTAEALGDDCLLCGLALFVPLLNIYALVTTRGKVRENKGIEGGLIGDLLMICCCGICSLVQEAQEMSVSTPLGAGESIARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPX8</accession>
    <name>A0A8B7XPX8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Polycystic kidney disease protein 1-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110974617</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082101.1">
        <property type="nucleotide sequence ID" value="XM_022226409.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974617"/>
    <dbReference type="KEGG" id="aplc:110974617"/>
    <dbReference type="OMA" id="DIPRMNN"/>
    <dbReference type="OrthoDB" id="10044145at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01752">
        <property type="entry name" value="PLAT_polycystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042060">
        <property type="entry name" value="PLAT_polycystin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730:SF1">
        <property type="entry name" value="PLAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46730">
        <property type="entry name" value="POLYCYSTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3047"/>
            <end position="3068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3252"/>
            <end position="3270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3290"/>
            <end position="3311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3477"/>
            <end position="3498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3510"/>
            <end position="3534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3611"/>
            <end position="3632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3854"/>
            <end position="3874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3895"/>
            <end position="3917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3945"/>
            <end position="3965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="3985"/>
            <end position="4007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="4048"/>
            <end position="4069"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="19">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="16">
        <location>
            <begin position="509"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="16">
        <location>
            <begin position="595"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="16">
        <location>
            <begin position="1165"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="16">
        <location>
            <begin position="1259"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="16">
        <location>
            <begin position="1364"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="16">
        <location>
            <begin position="1455"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="16">
        <location>
            <begin position="1535"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="domain" description="REJ" evidence="18">
        <location>
            <begin position="1594"/>
            <end position="2605"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="17">
        <location>
            <begin position="3091"/>
            <end position="3208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1935"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2138"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2196"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2262"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="3417"/>
            <end position="3440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4239"/>
            <end position="4300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4338"/>
            <end position="4410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="4477"/>
            <end position="4528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1953"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2138"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2300"/>
            <end position="2311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="2317"/>
            <end position="2359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2404"/>
            <end position="2420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="3417"/>
            <end position="3438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="4239"/>
            <end position="4248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="4367"/>
            <end position="4377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="4391"/>
            <end position="4407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="4490"/>
            <end position="4508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="4509"/>
            <end position="4524"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="3719"/>
            <end position="3732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022082101.1"/>
        </source>
    </evidence>
    <sequence length="4558" mass="497976" checksum="B2C3E6E9CDDC4A4F" modified="2022-01-19" version="1">[encoded data, 4558 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ56</accession>
    <name>A0A8B7XQ56_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear envelope membrane protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nuclear rim protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110975113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nurim family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082953.1">
        <property type="nucleotide sequence ID" value="XM_022227261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ56"/>
    <dbReference type="GeneID" id="110975113"/>
    <dbReference type="KEGG" id="aplc:110975113"/>
    <dbReference type="OMA" id="WSIWFPL"/>
    <dbReference type="OrthoDB" id="10050858at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033580">
        <property type="entry name" value="Nurim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31040">
        <property type="entry name" value="NURIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31040:SF1">
        <property type="entry name" value="NURIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022082953.1"/>
        </source>
    </evidence>
    <sequence length="272" mass="30959" checksum="DA1077A66CD720EA" modified="2022-01-19" version="1">MAGATFLPKAVLFVAISAFGLCVCFLTVFQFGMFLFREGLAMGVVDGRQSAHDKDAADPYVSDLLLDLLLIAAFVLQHSLLARRPWKDFIQWLGLDVVERSLYILATCGALQTLMQYWRPLFPESVLWALDTDSRWVWTVLGILSFLGWLCVVGVVMVLDYAELVGIKQVYYFLMDLDPPLQMKSREYQRLFQNFRHPVMTGLLIILWAVPVMTMGRLVLALSLTIYTFYGHSLDMRDYDYICQQHQLKKRTLRSPQGFRATGGRASSVGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRX3</accession>
    <name>A0A8B7XRX3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spore wall protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082942.1">
        <property type="nucleotide sequence ID" value="XM_022227250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRX3"/>
    <dbReference type="GeneID" id="110975102"/>
    <dbReference type="KEGG" id="aplc:110975102"/>
    <dbReference type="OMA" id="DEQGSIC"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="10"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022082942.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="40326" checksum="A66EA33B1C34E74B" modified="2022-01-19" version="1">MAIEGNGKCQAGRSLAKDFHRLMRNIASMSGGQARLVSWDETDLKKGITVSIIPDSGLYQDGEFMFSIVCGNKYPAQSPSVSCKTMIYHPNIDTIEGDGEICLNLLDDDNWSASMTLEDVVQGILFLLYNPNLEDPLNVLIGPGMDEEEFADNVRQSLDGGDVEGYYFERNQVVRGEGGALSSDRGGAVEGEAILTDVGRAEEGEVVITDTCGTKESKDRETVGTAEGGTGEGEGVVAHEEGAKEGGVVITDIGGTKEGKDREALVVTAEGERGEGEASVANVGGAKEGEVTVADEVERDGAGNLGIVIRDEGADKGQGIVFRCQTENQLLPEGDSNSKVTPPTEGRRGIWRRAWLRWRVQSKILVAFEDIYDLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTC8</accession>
    <name>A0A8B7XTC8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Programmed cell death protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110975216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083186.1">
        <property type="nucleotide sequence ID" value="XM_022227494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTC8"/>
    <dbReference type="GeneID" id="110975216"/>
    <dbReference type="KEGG" id="aplc:110975216"/>
    <dbReference type="CTD" id="5134"/>
    <dbReference type="OMA" id="HQVIRYS"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022083186.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39196" checksum="B480453DFDC2EF4C" modified="2022-01-19" version="1">MAAPMGKNEITLGFVEKAENWRLSRRFFPSKVGGKPAWLSMKDIPNSDNLKCRNCGIVCIFLMQVYCPISELDTCFHRTVFIFCCRDPACHTHASNSAFLVFRSQLPRANEFYDYEPPDEDSSPGSSLGAADEGLLCEVCGCFGGKKCAKCHVKSYCCREHQLVDWKAGHNKECGSLATGLAATGKEKILFPEFELVTESEDYSHEDKDDTGTEECHVAEDRQGLGVEELEKMALTESKEDRQFAKFKNRTDYEPDQVIRYQRGGQPLLISTENQPQQKDIPPCTSCGSVRQFEFQVMPQLLLHLDVDSLGQSIDWGTLLIYTCAKSCKGVSAYLPEFLWKQDVAVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTL8</accession>
    <name>A0A8B7XTL8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neural proliferation differentiation and control protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084198.1">
        <property type="nucleotide sequence ID" value="XM_022228506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTL8"/>
    <dbReference type="GeneID" id="110975753"/>
    <dbReference type="KEGG" id="aplc:110975753"/>
    <dbReference type="OMA" id="CETESGT"/>
    <dbReference type="OrthoDB" id="6270617at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009635">
        <property type="entry name" value="NPDC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352:SF2">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23352">
        <property type="entry name" value="NEURAL PROLIFERATION DIFFERENTIATION AND CONTROL PROTEIN-1 NPDC-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06809">
        <property type="entry name" value="NPDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022084198.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="21613" checksum="F3A3E754F73241B5" modified="2022-01-19" version="1">MGSNAADPQPKDQIAAAVRSSDDDAVKIDSDPSDISKAQNAPVTHDGEILLEDWQFILIVCGCVAVGVLGIAVAFLCWYKIQTTAKAQSEAEYPAYGLTGPSAHMPSNMSSGDRKLAQSAQMYHYQHQKQQMIAMEKREKGETQHDASDYDSEEENEDGDLTVYECPGLAPTGEMQVKNPLFSEDRHSETAAATEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTR8</accession>
    <name>A0A8B7XTR8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein LOC110975282</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110975282</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083316.1">
        <property type="nucleotide sequence ID" value="XM_022227624.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975282"/>
    <dbReference type="KEGG" id="aplc:110975282"/>
    <dbReference type="OMA" id="CIDRGWL"/>
    <dbReference type="OrthoDB" id="8440449at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000056">
        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000068">
        <property type="entry name" value="transmembrane protease serine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000003">
        <property type="entry name" value="Transmembrane serine protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF7">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="83"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="356"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="513"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="546"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="15">
        <location>
            <begin position="734"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="16">
        <location>
            <begin position="878"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="13">
        <location>
            <begin position="1150"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1308"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="319"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="739"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="747"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1114"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1121"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1133"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1272"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="1279"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="1332"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022083316.1"/>
        </source>
    </evidence>
    <sequence length="1346" mass="147471" checksum="CE5C85C690ED6487" modified="2022-01-19" version="1">MSFFPECPQFGSARRVCASLCSRALECVGLETNSTSLQCDVYPDRGILSTSEGCLFDDEDVLQTGNCGRRPAASPSLNPFSRIIGGAQSHIANWPWIGSYQYRSGFHACAATLINPSWAVTAAHCGAQHQLVFGSSLLNIPNGYSHVHRIARVFFHPGYDNPRYHNDIALVKLASPVPYTDTIQPACLETDEDEVDKYDTCHVVGWGRTSLYGSVSPVLKEAQVPLVTWEQCKTYADVRENVFISSDQICAGTADGNNATCSGDSGGPLICRGTSGRWKLVGITSTGYRCDETSPGVYTRISHYIDFIRYTIASDADLCTGETYRCAMGACLRSELVCDTYPDCEDGSDEISCEPGGSRLVQIRGNEGTHISSPFYPRNYISNLDVIWNVVTDEGFKISIQFITFRTSSNLDTLRVGDGVYLSNSTGEFFMWNGTKFPPSLLSSGSAMWLRFTSLSVYPSGGFNISVTGVPLNESLNCEGEFDCGHSVCIDRGWLCDGQTDCIDGRDEEFMCGCVSNRCLNDGTCQPVGGSGFYCQCREGFGGLLCEATLINLGANESVLISSPSYPNDYTNNLDLMWIVETVDNRQILIDFIAFNTESCCDHLRGGNGEDFSNSSTTLFRWSGSSLPPRVSSNGNVMWLRFTSDFSVTRSGFLLSARSVSSNVIFECEAYSYTFEESDRCDGIIQCPNGDDEKDCDCVANEYRCRDSICASSADAECNGIPECLDYSDEGVTCNTAYCIEIQSEVCSAILTYNTTYFPNDFVSSHRQANDFIAQHLPQLTANCTDSERLALCMSFFPECPQFGSDRRVCSTLCSRALKCVGVDTDSNTTSLSCEVYPDRGLLSTSDGCFYHRADVLQAGDCGRRPAASPSLNPFSRIVGGAQTHIANWPWIGSYRHASGSHGCGVSLISRYWAVTAAHCTHLQYVVFGSSTLDIPFNYQHVYRVSKVFNHPLHNSPRYHNDIALLKLASPVRYTDTVQPICLQIADNETEVYDRCHAIGWGRTSYGGIVSPVLKEARVPLLGWEQCKANSEIQGRLFVSSSQICAGIGDETNKTCNGDSGSPLVCQGTDGRWKMVGIVSTGVRCGQTAPTAFTRVSQYIDFIRYTIASDSNLCSVDDFRCSSGTCITPELVCNTFPDCDDGSDELSCDPGGSLSVSLDENERIHLLSPFYPMNYINNLNVIWNIFTEDGFKISIKFVTFSTEQGDILQAGDGVYAVNGSTNFFSWSEMRRPPSLLSSNSTMWLRFTSNSFNTRRGFNITVTSVPSNESLNCTEEEFDCGHSVCIDRGWLCDRQIDCSDGRDEEFQCGCVLNTCLNNGTCHPVGGSGFNCHCHEGFGGTLCDIGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTT2</accession>
    <name>A0A8B7XTT2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein argonaute-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110975328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083415.1">
        <property type="nucleotide sequence ID" value="XM_022227723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTT2"/>
    <dbReference type="GeneID" id="110975328"/>
    <dbReference type="KEGG" id="aplc:110975328"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000001">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000005">
        <property type="entry name" value="Protein argonaute-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="10">
        <location>
            <begin position="256"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="11">
        <location>
            <begin position="547"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="856"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022083415.1"/>
        </source>
    </evidence>
    <sequence length="901" mass="101756" checksum="CF084AD444BC243F" modified="2022-01-19" version="1">MYQPHQPRDFAAMGLPPPGQQPIRPPIMHIGMPPLLPGLPGLPPAQPKPESKMPPRPGFGKDGRPIMLRANHFKITIPHDTINHYDVTIVPEKCPRRVNREVMDTLVKHTNRIFQNCKPVFDGRKNLYCRLELPIGKERVDLEVTLPGEGKERTFKVSIKWVAKVSLQALADALEGRINIIPYDSVQALDVVMRHLPSMTYTPVGRSFFSPPDDYFHPLGGGREVWFGFHQSVRPSKWKMMLNIDVSATAFYKAQPVIDFMCEVLDIGTSADQRRPLTDSQRVKFTKEIKGLKIEITHCGNMRRKYRVCNVTRRVAQAQTFPLELENGQTVECTVAKYFKDRHRRILQYPFLPCLQVGQEHRHTYLPLEVCNIVPGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVHRAQFNNDPYVQEFSLNISTEMVRIEGRVLPAPKIQYGGKQQSGRMLAIPTQGVWDMRGKQFHTGVKISTWAIACFAQQHQCKEEALKNFTSQLQKISSDAGMPIGSQPVFCKYAQGADQVEPMFRYLKRQFPDLQLIVVVLPGKTPVYAEVKRIGDTLLGIATQCVQMKNVNRTTAQTLSNLCLKINVKLGGVNNILVPSQRPALFRQPVIFLGADVTHPPAGDDKKPSIAAVVGSMDAHPSRYTASVHVQQHRQEIIADLKVMVREILIQFYQTTHFKPARIILYRDGVSEGQFPQVLAHELRAIREACMSLEAGYQPGITFIAVQKRHHTRLFCADKKEQIGKSGNIPAGTTVDTGITHPNEFDFYLCSHAGIQGTSRPSHYHVLWDDNDFTADDLQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKDHDGYISGHHSGTNSNGDGSHTTSTSGGRSIEEMMRAVKVHDDILRVMYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0J5</accession>
    <name>A0A8B7Y0J5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cholecystokinin receptor type A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110977138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086684.1">
        <property type="nucleotide sequence ID" value="XM_022230992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0J5"/>
    <dbReference type="GeneID" id="110977138"/>
    <dbReference type="KEGG" id="aplc:110977138"/>
    <dbReference type="OMA" id="YAFHYEE"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="38"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022086684.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44292" checksum="EC91B36668E1E318" modified="2022-01-19" version="1">MDSLATNGNVTVTDEPTSFGDVVLKIIYTIIGLLGIVGNSLVIYLVYRVPSLRSVTNVLICNQAIIDLTSSVFFVCLYLLPKPSLPESAVAASVLCKLWLSDWPLWGFSVSSTVNLVLLTMERYFAIKHPIKYRTRFTMRRAKALAVLPWCVGPLHELAWALVQTVDAEGNCDPSWPSVTLQQILGVIFFIDHYMLPVTIMMYVYTTIIMKLRRDWRSSSVSLPRTGHAQTTTNNSISSNNNDSKVISGAEGRSTSGRRQSTFRSAVLPPSRKHFSLLASKSVLRTLLIVSASYIVCWGPNETIYLLFNLGVSVEFNGLYHNMSVVFALCNMCLNPIVYAFHYEELKKALRKKLPCKTGWKARPRPCCCKKSKTFELGGLEQHLATVTSPHGSIQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0Q8</accession>
    <name>A0A8B7Y0Q8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box/LRR-repeat protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110977173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086749.1">
        <property type="nucleotide sequence ID" value="XM_022231057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0Q8"/>
    <dbReference type="GeneID" id="110977173"/>
    <dbReference type="KEGG" id="aplc:110977173"/>
    <dbReference type="OMA" id="SINLWYC"/>
    <dbReference type="OrthoDB" id="27842at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000647">
        <property type="entry name" value="Leucine-rich repeat-containing 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086749.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="70489" checksum="848EA57CAC0E93C7" modified="2022-01-19" version="1">MDLPTELISYIMRFLTSSERHEASLVCKKWYYASLDPALHQSSVITLRASNSTGEKFHHLGQRKSPSLVVSHVDGSRDCGQVLEEIGHHLGPHLTSLSLRGSDVTETVFVGIIGHCPGLQRLDVSCCNSLFMSGNLLQKAEDREKVAQPLENVTSLNLASNRYLSDILFNRLVGVMPSVAKLSLASCNIIHQSDAYISADRKSSSFMSLSNFLMYLQHHADKILSLDLSCTGIGSEALHLISHVKGLVLEELTLKKCSGISNEGVASLVKKQSSLRSLDLSSVASLNSPSLIAICKYLPHLEHLNASEWSQLEPQASEYLSSLRHLKSVNMSNCYHVGLHHLCKGLGSSNSSHLVSLSLGGCGSVRDEVVLSLVKSLPQLEQLDLSSCFGVGDSSVHAISRFLPNLKKLRLAWCKKITDFGLLGLDQNAPVFITDNEATKHYSDRFTKSHSNMGFFKRPSFNEKILKIPEKEIQRLMDAPDQVNLTALTRLESLDLTACNHLTDICVSHAVRFPCLHSLTLSLCSNITDQSLAALAANNPNLVELLIGHCHQVTDAGLKVLVQRRRGLRSLDVCGCEKVTDATLLALGQYTKHLQHLNISQCGGVTMATAEKLQQQVPTLRSLQMAHISSGGSAFYHYQPISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0W3</accession>
    <name>A0A8B7Y0W3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Esterase OVCA2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110977197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086799.1">
        <property type="nucleotide sequence ID" value="XM_022231107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0W3"/>
    <dbReference type="GeneID" id="110977197"/>
    <dbReference type="KEGG" id="aplc:110977197"/>
    <dbReference type="CTD" id="124641"/>
    <dbReference type="OMA" id="EEPRGWW"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000073">
        <property type="entry name" value="esterase OVCA2 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086799.1"/>
        </source>
    </evidence>
    <sequence length="228" mass="25235" checksum="460006E2D0D39554" modified="2022-01-19" version="1">MSSSASGASDKLKILCIHGYRQNAQIFRERTGALRKIIKKYTELVFISAPNKVLPAEGEEDLDQRGWWFSTIDHTFKANQVCDVNPGLQESLTTVAQTFNDLGPFDGVLAFSQGAAFAAILCALQNQGDTRFPFKFAILVASFRSLSSNHAAFYANPINCPTLHVFGDTDGVIPRESSEDLLPVFVNPQILNHPGGHFVPASAPQKKVYLEFLEHWYTKKQEENSAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1Y4</accession>
    <name>A0A8B7Y1Y4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110977056</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022086537.1">
        <property type="nucleotide sequence ID" value="XM_022230845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977056"/>
    <dbReference type="KEGG" id="aplc:110977056"/>
    <dbReference type="CTD" id="23020"/>
    <dbReference type="OMA" id="MNPKEFN"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000048">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="492"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="686"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="1339"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="201"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022086537.1"/>
        </source>
    </evidence>
    <sequence length="2149" mass="244499" checksum="E4C304C75AB5D1FF" modified="2022-01-19" version="1">MADATARSLQYEYKANSNLVLQVDRSLIERRGRDEATGEVMSLVGKLEGSKMGDRAQRTKPPMQEERKIKRQKRDDARYDMNKFKGQTLLSQGIEDMVGIYYRPKTQETRNTYEALLSFIQAAIGDQPRDILCGAADEVLATLKNEHSKSKDKKKELELLLGLLAEERFALLVNLGKKITDYGSEKEKKAIEEEIDETFGVNVQFEASDDDDDPDDCGEVKGEESEDDDDEGGMDTGYDATLSTSLGGSEAAMGMAKKDLHPRDIDAFWLQRQLSKFYDDPNVSQARSSEVLDILKTAADDGQVENQLVMLLGTNQFDFIKILRQHRKMILYCTLLNRAQDSAERQRIEDKMRFDPSLAPILHALTETDKEDIIKEERARRAAARQSKVDADLDAMETDEPENVMQATEMLEIDDLIFAQGGHLMANKRCQLPDGSFRRQRKGYEEVHVPALKPKPFDDTEALVPIDRLPKYAQPAFEGFKSLNRIQSRLYKSALESDENLLLCAPTGAGKTNVALLTILREIGKNINLDGTINTDAFKIIYIAPMRSLVQEMVGNFKKRLDSYGITVSELTGDHQLTKDQIHATQIIVCTPEKWDIITRKGGEKTYTQLVRLIIIDEIHLLHDDRGPVLEAVIARTIRNIETSQEDVRLVGLSATLPNYQDVATFLRVNTDRGLFFFDNSFRPVPLEQQYIGITEKKAIKRFQLMNEIVYEKVMEHAGKNQVLVFVHSRKETGKTARAIRDMCLEHDTLGQFLREGSASTEVLRTEAEQAENLELKDLLPYGFAIHHAGMNRVDRALVEDLFADRHIQVLCSTATLAWGVNLPAHTVIIKGTQIYNPEKGRWVELGPLDVLQMLGRAGRPQYDTKGEGILITSHSELQYYLSLQNQQLPVESQFVCKLSDNLNAEVVLGNIQTMKDAVTWLGYTYLYIRMMRNPTLYGIPADAKDTDPYLESHRINLVHAAGCLLDKNNLAKYDRKSGHFQVTELGRIASHYYCTNESIATYNSLLKPTLSEIDLFRVFSLSSEFRNMVVREEEKLELTKLLERVPIPIKESIEEPSAKVNVLLQAYISQLKLDGFALVSDMVYITQSAGRLIRAIFEIVLHRGWAQLTDKTLSLAKMIDKRMWQSMNPLRQFRKIPEEVVRKIEKKSFPWERFYDLGPNEIGELIRLPKLGKTLHKYVHQFPKLELATHIQPITRSTLRVELTVTPDFQWDEKIHGNSEAFWILVEDVDSEIILHHEYFLLKSKFAEDEHIVKFFVPVFEPLPPQYFIRLVSDRWIASETQLPVSFRHLILPEKNLPPTELLDLQALPVSALRNPSFEALYSSKFSVFNPIQTQVFNAVYNMDENVFVGAPTGSGKTIIAEFAILRMLTQAPEGRCVFVTPLEALAEQVYTEWYAKFQMQLGKKVVLLTGETSTDLKLLAKGNIVISTPEKWDVLSRRWKQRKNVQNVNLFVVDELQLIGGDNGPVLEVICSRMRYISSQIERNIRILALSSSLANAKDIAQWLGASTTNTFNFHPNVRPVPLELHIQGFNITHTASRLIAMVKPTYNAILKYSPNKPVIVFVPSRKQTKLTAIDLLTYSSAEDTEESRFLHVPKEDLAGHISKVNDETLCEMLENGIAYLHEGLSELEKKVVEQLYTSGAVQIVVAARNMCWGMTFPAHLVVVMDTQYYNGKIHAYVDYPVTDVLQMVGRANRPDIDQEVGKCVILCQGSKKDFYKKFLYEPLPVESHLDHCLHDHFNAEVVTKTIENKQDAVDYLTWTFLYRRMTQNPNYYNLQGVTHRHLSDHLSELVENTLQDLEQSKCVSIEDQMDISPLNLGMIAAYYYINYTTIELFSMSLNNRTKIKGLIEIIASAAEYEQIPIRHHEDSVMKQLSSRVPNKLANARFNDPHVKTNLLIQAHLGRMQLSAELQSDTEDILGKALRLIQACVDVLSSNGWLSPALAAMELAQMVTQAMWNKDSYLKQLPHFSSDLIKKCTEKGVESIFDIMEMDDDDRNELLVLADAQMADVARFCNRYPNIELTYEVQEKDSLESGSPVVVNVILEREDEVTGPVVAPFFPQKREEGWWVVIGDTKTNSLISIKRLTLQHKAKVKLDFVAPSPGLHNYTIYFMSDSYMGCDQEYKFGIEVREARDSSSEESDEDSSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4N5</accession>
    <name>A0A8B7Y4N5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977925</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088154.1">
        <property type="nucleotide sequence ID" value="XM_022232462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4N5"/>
    <dbReference type="GeneID" id="110977925"/>
    <dbReference type="KEGG" id="aplc:110977925"/>
    <dbReference type="OMA" id="TITLCHK"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088154.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15721" checksum="B66E4E727B361A84" modified="2022-01-19" version="1">MSAIFRKTHSPRMGNTTSEPAQGPIYLKSLQPSTVRRETTDHDPDITSRPEDVSLSVGMSHDFKVAYQAFNGPVEITVEKNNGTDLLSFETISRCAEIILQIDRAQKQHDGTYKIKIKDESRSTRRSANPAQASWKVKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y501</accession>
    <name>A0A8B7Y501_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein NDNF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110977506</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Secretory protein that plays a role in various cellular processes. Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus. Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system. May also act through the regulation of growth factors activity and downstream signaling. Also regulates extracellular matrix assembly and cell adhesiveness. Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087410.1">
        <property type="nucleotide sequence ID" value="XM_022231718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y501"/>
    <dbReference type="GeneID" id="110977506"/>
    <dbReference type="KEGG" id="aplc:110977506"/>
    <dbReference type="CTD" id="79625"/>
    <dbReference type="OMA" id="YLFRDTS"/>
    <dbReference type="OrthoDB" id="9872501at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019326">
        <property type="entry name" value="NDNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045805">
        <property type="entry name" value="NDNF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055271">
        <property type="entry name" value="NDNF_Fn(III)_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056225">
        <property type="entry name" value="NDNF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14619">
        <property type="entry name" value="NEURON-DERIVED NEUROTROPHIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14619:SF3">
        <property type="entry name" value="PROTEIN NDNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10179">
        <property type="entry name" value="NDNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19433">
        <property type="entry name" value="NDNF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24354">
        <property type="entry name" value="NDNF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="200"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="10">
        <location>
            <begin position="464"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022087410.1"/>
        </source>
    </evidence>
    <sequence length="586" mass="67130" checksum="B40C336D0B86D880" modified="2022-01-19" version="1">MVVSVVIRSRTERSQKMTSPRLTPSTVTMALLLQFLVVSFSRLSWAQQLPTRDEEIFQLQMANPESVADTKVLPDGAETKGYVFKGTRKFFYFVVEEDNAPVAITVTPCAAQLDWTLSLMDLPEDGSGSSDDQLSEQRPRRHPNTKLGTVVKTYVGYDVSTYVTYSSPAGIYTLEIKSPEKSTSVRIYATTTPDSDHLYPELPTDPRLDITSFRKNKVSLAWKPSPSDVIYREPIVYCVALNARQNYHTWCSVQSCLYGDQPPAQPEHAGFGFESERAERRQHRRDRNREREGRGRDREEEDDIIVECVGKKTLHTFTNLEPAKRYYFDLFAVDETNNRSVAYIGTSIITRPGPEIRKHITLKDGKLRTSSVRKSSPVKTFDFSVGETVQDVMVTVQPCIESVQAEVWRDGTKIRSSNIRNLKDFWIRDISGDIQIKVKSLRRGSTHFRIFATTRPNKYPFPRLPADKRIKVFENLRQCDSVTLAWLSTKEVSQYCLYKRVEKQAKKPTKRTRGRNRQCLEPDMRKRTEKVICRPVSGPDVERDVLMEEISGLTPDTTYIFDVYVNSFGKQTLAYRSARVTTKKVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8Y0</accession>
    <name>A0A8B7Y8Y0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Importin subunit alpha-8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110978753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089693.1">
        <property type="nucleotide sequence ID" value="XM_022234001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8Y0"/>
    <dbReference type="GeneID" id="110978753"/>
    <dbReference type="KEGG" id="aplc:110978753"/>
    <dbReference type="OMA" id="ICDGSIP"/>
    <dbReference type="OrthoDB" id="21522at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16356:SF1">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16356">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 6 TMCO6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022089693.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="27890" checksum="A15BA9A7E6AB8451" modified="2022-01-19" version="1">MEGGVAQPLIQLLHLDRDQGTMSEAAWTLTYLTAGGEYEQTFVSLGLIPRVVAALDKLSNQTPHDSVVVTPLVRCLGNICSGPEELIAMATADGSLLPSISRLLQSDHRHIKKETLWALSNMTEVASVCQQLVSLGMLPSIVSCLENTYDIKREAVVCLCNLAYQGAAFCQKLLHYGAFPGVISMLKNQDLDAIGLALGFSDMILKSDSNAKHLFEESGGLTLLEPLEYHNNPEIQRQVAEFLEVYFYQDEEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9G9</accession>
    <name>A0A8B7Y9G9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ornithine decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110978035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022088366.1">
        <property type="nucleotide sequence ID" value="XM_022232674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9G9"/>
    <dbReference type="GeneID" id="110978035"/>
    <dbReference type="KEGG" id="aplc:110978035"/>
    <dbReference type="OMA" id="VMQYGVQ"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="12">
        <location>
            <begin position="48"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022088366.1"/>
        </source>
    </evidence>
    <sequence length="439" mass="48568" checksum="DBF34AF934B9DAF3" modified="2022-01-19" version="1">MDDPSPHSGVKISMYEKESISMIAKWSIEANSSAERDYDDPFYICDLGDVIAKDRKWQELLPTVETFYAVKCNPDLAILRLLVGLGRGFDCSSKREIQMVLDAGASPDRIIYANTCKQESHLRYAKEKGVSLMTFDSADELQKIDRVYPEATLVLRMRYDDPNAVYKLGSKFGCSQDSIPRLMELAKTLGLNVVGISFHIGAGARDPNMFAGAISCAKTLFGVGKAVGYDMTLLDIGGGFPGKTSFRIGFQQFAEAISESLEEHFPADCGVRVIAEPGTFYVQSAVHLVANVIATRKVGASSDILQENSKLKKHYFVNTGLYNSFNALYTVPDYFAPPCPLRELEEDEPFYPSCIWGPTCDATDCIFPDCRLPELRAGDFVIFRDMGAYASSASCDFNGFGTPTSRYTATRKYLPLLREVFQGCATENVDIDPQTKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA57</accession>
    <name>A0A8B7YA57_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110979003</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="RefSeq" id="XP_022090134.1">
        <property type="nucleotide sequence ID" value="XM_022234442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YA57"/>
    <dbReference type="GeneID" id="110979003"/>
    <dbReference type="KEGG" id="aplc:110979003"/>
    <dbReference type="CTD" id="978"/>
    <dbReference type="OMA" id="MEAKTHA"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="48"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022090134.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16041" checksum="C14F3141F67A3465" modified="2022-01-19" version="1">MADTLPAEIQNLIELCQTAKKNAHCPYSKFRVGASLLTKDGKVFSGCNVENASYTLGLCAERCAIFKAVSEGYKEFRAMAVGSDVKDHFLAPCGACRQVMHEFGGKNLEVYMTKPDLSFQRIAMHELLPYGFDAEALSHKRIEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAB0</accession>
    <name>A0A8B7YAB0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Protein gustavus-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC110979035</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090185.1">
        <property type="nucleotide sequence ID" value="XM_022234493.1"/>
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    <dbReference type="RefSeq" id="XP_022090186.1">
        <property type="nucleotide sequence ID" value="XM_022234494.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022234496.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110979035"/>
    <dbReference type="KEGG" id="aplc:110979035"/>
    <dbReference type="OMA" id="PIISAVW"/>
    <dbReference type="OrthoDB" id="5547302at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03718">
        <property type="entry name" value="SOCS_SSB1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000007">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY"/>
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    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF11">
        <property type="entry name" value="PROTEIN GUSTAVUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="40"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="226"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022090185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022090186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022090188.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="31433" checksum="C46CB7AF70EF1A08" modified="2022-01-19" version="1">MSRSLVMGQKLSGGMKQIAREPSHKITQRELVYSGDLVKPNRLDTLLDMPPADKEMQYKYAWNEEDRSLNIFVKEDDPFTFHRHPVAQSTDCIRGKVGFNRGLHVFEVFWNSRQRGTHAVVGVATASAPLHCVGYQSLVGSNAESWGWDICRKKAFHDAKHKSGTPYPLLPNADNYPVPDKFLMVLDMDEGTLSFIADGQFLGVAFRGLKGKRLFPIVSAVWGHCEISVKYLGGLEPSPLPLQDLCRRGIRVSVGKEHLEDIYQLPLPTMMKRYILYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YD50</accession>
    <name>A0A8B7YD50_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteoglycan 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090310.1">
        <property type="nucleotide sequence ID" value="XM_022234618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YD50"/>
    <dbReference type="GeneID" id="110979091"/>
    <dbReference type="KEGG" id="aplc:110979091"/>
    <dbReference type="OMA" id="FDARCER"/>
    <dbReference type="OrthoDB" id="10580944at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090310.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="65691" checksum="926956B1D0B10B33" modified="2022-01-19" version="1">MEGTEIQPLFVYIPVCVVVVFVVLVFTFGFRSPTQPPSSMFEDENERRNRRGKRVKKLSGSDSKPSTNGHAKLLLDSPSEDKQVKGHRVEEGPAKETPPKVSPKKDKPVKNKASEGSIEKGGEAPKKVAAIKEDEDSRGKDEGEAWITVTGTSRKEKKQNKQASVKNGEAPAKPASKSPRESPRGARDDQKGSQKGPREGVGKEEGERKTEISQKPKGSPKKVVENQIKASSVQTTRSAPIPEPSPDQGKKRKKKGQSEQQETANQTTESTGLTNGVAADADPANQKDAGADEDGFTPSKSRRNRKKLKTTQEDTPKLVPPPADNKQESPPPSSPQQSPAKKSGKKSADKISPAKAKPDAESSKAPAAPTPEGSKKPEGKGSSPSKNKKTAKTEETSPIKTDAKPSKEKKSGQKVNNSAPSSADASPAKSKSSSEGSPAKSGKKAGAGKQSSQTKKDEKQLQDTQTQSSTAPVASTKSKSKKKPKKESTSPTPEPTSKQSASPKSEVVQSTEPKVDSETSKSSRKKNKRKEGNENKGKSSEAINGESSHSLPLLKAEGVPSAKSPDTSSDKLPSGSPTPKPTPVTPVQATVPEVPENDNWVEAKPKKVRKKVRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDM6</accession>
    <name>A0A8B7YDM6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Kelch domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110979660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091359.1">
        <property type="nucleotide sequence ID" value="XM_022235667.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091360.1">
        <property type="nucleotide sequence ID" value="XM_022235668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDM6"/>
    <dbReference type="GeneID" id="110979660"/>
    <dbReference type="KEGG" id="aplc:110979660"/>
    <dbReference type="OMA" id="MGKLLQF"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46228:SF2">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_4G14350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022091360.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46085" checksum="9A22CE14DAB8B8D1" modified="2022-01-19" version="1">MESAGRRTQARGLKPVPRSGHVAVTYGGLMLVWGGYTDLPALSSESHWGDQYLDGSELWCYDIEASLWDVWSTRKSPPGMSGSCAACIGRHMYVFGGYSADGNSNKLYRLDLKTKVWMHLKPNGKAPSPRDKVACWPYRDKLVFFGGFGPPPDNEDVTMDGVGQWRIDLSSLNVWSPTRGWNNHLVVYNITENSWTHVQIKGYQPCPRAAHAAAVIGNKGYLFGGRFEGSRMNDLHVLNLDTLQWVESLNPVSGDIPMGRSWHCMAPVSDRHLLVYGGYSTEGVPLNDVWVLDVENKTWHQQDSLPSDTRIWHTAVSGVDAGEVVVFGGCSNDLLDPYERSVHSSKIFKFFFSPKNLKRLCSEAIVTNIAMLEKELNALPSVLQRTIELLLRGCRKGDAKKHGYNLRARPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFV0</accession>
    <name>A0A8B7YFV0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fibroblast growth factor receptor 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979609</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091270.1">
        <property type="nucleotide sequence ID" value="XM_022235578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFV0"/>
    <dbReference type="GeneID" id="110979609"/>
    <dbReference type="KEGG" id="aplc:110979609"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002448">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF620">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR TORSO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034138732" evidence="6">
        <location>
            <begin position="30"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="416"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="703"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091270.1"/>
        </source>
    </evidence>
    <sequence length="790" mass="88870" checksum="9341597C48909CAB" modified="2022-01-19" version="1">MTSHVTCVVYASSWRGVLFLSIMPNLARSFIDCTGIGIGRPYHPSCCIPQIVDRNTVNPTFIVRPVTVDRWELDVNISWAKPQGEMNFDAYGVHRLDYTRLPPVIASCDDYYSNLIIVQVEWILFRNVPFGSTPFFIVFTANRTAELINREQSIKEIAMADCYDSTRSISFCRTQSIEVAGSPIDLRVDLIIAEEQAGDATPIVSVMVSWNPPVQIKSNATLVGFALVWYMNEAVQLPAVNIAVPMSMREYDDPFSLSFNHSIQGVEVTNENNFRVQVRAKINDTECSGVTCLGNEAVLSFSVGPENVTTVLPDSPTSTISGPNGDVSSSQPIQYIPYPTPSILPYVLAGVATLLLCLLLPVLFRHLRKQRRPDSMSQFIPDHEESNYASKSISISNVMDESFSHFECDRNALTEISPISQIGKGSFGVVYKAFAYGTVSGKLGYYPVAIKGLKENATRDLKESFLEEIRLMIDIGRHPNILAILGCCTVDEPYLLITEFMTYGDLLHFLWKTRESKLTEEDPVYQLTELNLFQIARQVACGMEYLSQTRYYHGDLAARNILVGKNLLVKVSDFGLSDDTYEMGYKRLDEGRKRAVKWVSLETNTTNRCSIKSDVWSFGIVLYEIFTRGNAPYQGLSNQEVIEKLKSGYRMERPKDCPSDVYAMMRKCWQENPSKRPSFTDLYQSLDKMLGQHSDYLNFEESETCPGESKDVRTEGEQSQDSSLSSGKPDELKLWLHLNGSFPGGTKTIDFVPFNQVGENFTQSNNSSSRSVELEEKIFKRDRDCDVLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJI2</accession>
    <name>A0A8B7YJI2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Stearoyl-CoA desaturase 5-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110980103</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092570.1">
        <property type="nucleotide sequence ID" value="XM_022236878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJI2"/>
    <dbReference type="GeneID" id="110980103"/>
    <dbReference type="KEGG" id="aplc:110980103"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="118"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022092570.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42960" checksum="721FAAADAF61D129" modified="2022-01-19" version="1">MCGCTPTYTAFVRTKKKQNKTRVMAPKNIVYGTVEVAQEDTPEDDTAATNPLDDDPDMPSTAEGPPRTATGTAKPGDPSENQTRIVWRNVILMAALHVVSVYSFFFLTWKCRPYTLLWAVGMYVCSGLGITAGAHRLWAHRCYKAKLPLRILLAIFNCMAFQNDIFEWARDHRVHHKYSETDADPHNATRGFFFSHVGWLLVRKHPKVIEKGSKINLRDLIDDPVVRFQRKYYQSLMFFFCFVGPTIVPIYLWGETFWNTLCVATLLRYCFLLNCTWMVNSVAHLWGSRPYDRFINPAENRLVSSLAIGEGWHNYHHTFPWDYKTGELGWRINFTTMFIDLMAALGQVSDRKVVPKATIVARKKRTGSLVAAAGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK09</accession>
    <name>A0A8B7YK09_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing CTD phosphatase 1</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110979982</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 17">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022091896.1">
        <property type="nucleotide sequence ID" value="XM_022236204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK09"/>
    <dbReference type="GeneID" id="110979982"/>
    <dbReference type="KEGG" id="aplc:110979982"/>
    <dbReference type="CTD" id="134510"/>
    <dbReference type="OMA" id="TVHTPKY"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01813">
        <property type="entry name" value="Ubl_UBLCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000060">
        <property type="entry name" value="ubiquitin-like domain-containing CTD phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000050">
        <property type="entry name" value="Ubiquitin-like domain-containing CTD phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="135"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022091896.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="36737" checksum="A5D983C4D5A235F7" modified="2022-01-19" version="1">MAAPTNVVVKWNGKEYTISDVGESETVLDLKCMISKQTGVLPERQKLIGLKLKGKVPPDDTVISALQLKASTKLMMVGTREETIAAANEKPKDMDEIIDDFDVEDEEIQTEHREEFLEKIQRRVRDYEIKVLNDPRPGKKLLVLDVDYTLFDHRSVAEHALELKRPFLHEFLTSAYKNYDIVIWSATGMKWIEVKMKELGVASHEDYKITFMVDSGACISVQTPKYGMVDTKPLGVIWGKFEQYTSSNTIMFDDLRRNFLMNPQNGLKIRPFRQAHKNRDKDKELLRLARYLEDIADLADLSHLNHKHWESYRPPKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKX0</accession>
    <name>A0A8B7YKX0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intraflagellar transport protein 172 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110980121</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IFT172 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092171.1">
        <property type="nucleotide sequence ID" value="XM_022236479.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980121"/>
    <dbReference type="KEGG" id="aplc:110980121"/>
    <dbReference type="OMA" id="LKRTIWQ"/>
    <dbReference type="OrthoDB" id="2186662at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000008">
        <property type="entry name" value="Intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000012">
        <property type="entry name" value="intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000013">
        <property type="entry name" value="intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001535">
        <property type="entry name" value="Intraflagellar transport protein 172 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002910">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056168">
        <property type="entry name" value="TPR_IF140/IFT172/WDR19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056157">
        <property type="entry name" value="TPR_IFT80_172_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722">
        <property type="entry name" value="IFT140/172-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15722:SF2">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 172 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24762">
        <property type="entry name" value="TPR_IF140-IFT172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23387">
        <property type="entry name" value="TPR_IFT80_172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT80/172/WDR35 TPR" evidence="10">
        <location>
            <begin position="627"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="IF140/IFT172/WDR19 TPR" evidence="11">
        <location>
            <begin position="963"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022092171.1"/>
        </source>
    </evidence>
    <sequence length="1751" mass="198873" checksum="64AC7CB4FBC85C18" modified="2022-01-19" version="1">MQLKHMKTLLAPQDGAAKITALAWAPNNTKMAVCTVDRVVLLYDEHGERRDKFSTKPVDAKFGKKSYTVKALAFSPDSTKIAVGQTDNIIYVYKIGDDWDSKKVICNKFIQQSAVTCMIWPPDSNIVFGLADGKVRIANTKNNKSSTVYGTDSYVVSLAPNMSGKGILSGHADGSVVRFFFEDEGTGESQGKICTHPCPPYALCWAGSSIVAAGCDKRITVYGKEGRVGQQFDYSRDADEHEFTVAVNSPSGQSVVVGSYDRLRVFNWAPRRGMWEEAKMKEIKNLYTITALAWKKDGSRLVAGTLCGGVELFDCCLRRAIYKNKFEMTYVGLSQVIVKNLSSGTRVVLKSHYGYEVDEVRILGKDRYLVAHTTDTLLLGDLSTNKLSEVPWQNTGGNEKFFFENESVCMIFNAGELSLVEYGCNEILGCVRTEFMNPHLISVRLNERKQLGVEDNKKMAYLVDLKTISIVDLIMGFNIATLTHDSKIDWLELNETGRKLLFRDKRLRLHLFDIDTQTKTTILNYSSYVQWVPQSDVVVAQNRGNLCVWYNIDHPERCTMFSIKGDIVDLERANGKTDVIVTEGVATISYTLDEGLIEFGTAIDDGDFTRAVAFLETLEMTSETEAMWKTLSRLSLEAKQLHIAERCFAALGDVAKARYLRNVNKMAAELAQEIGGDGTRHYSVRAKLAILNKDFKEAESVFLEQNNIDEAMEMYQELHKWDEAIAVAEAKGHPELESLRRNYYQWLMDTGQEEKAGEMKENEGDHHAAINLYMKAGMPARAARLATSRGDLMENRDLIQRIAAALIKGEFYERAGDLFEKTRDDQRALECYRRGKSFRRAVELARASYPTEVVRLEEEWGDYLVSQKQMDAAINHYIEAGCSQKAIEAAIHSHQWNKAIQIIEIQDPTVGEKYYPKIAKHYANIRNFEMAERYFVQAGMTKEAIDMYTAAGKWEAAHKLAVTCMKSEEVAVLYVTQAQQLESQGKFREAERLYLTVDEPDLTITMYKKQRQYDHMIRLVKQYHPDLLQDTHLHLAKELEGEQAFRQAEHHYIEARDWKAAINMYRAQDLWDEAYRVAKNHGVANTAKQVAYLWAKSLGGDSAVKLLTKFGLLESAIDYATENCAFDFAFDLARTAMKNKMPDISLKHAMFLEDEGKYQEAEAAFIKAGKPKEAVLMYVHNQDWDSAQRVAEEYDPDSVTDVLIGQARYAFDQKEYQRCEAFLLRAQRPELAIKYYKQSNMWQDALRVCKEYVPHKLKQLQDEYDREVLNKGSRGADTLVGQAKEWEASGEYNRAVDCYLKVTTQQTNDEKVLVACWTKAAELSQKFLDTPKALSVVRIVGPRLADVQKYKEAAEIYLSVDMIKEAIDTLMEGGEWNKAKKVAKELEPRYENYVDTKYKEHLKSEGQAESLIGVDVIAALDMYAGRGEWDKCIETAEKQGFKVLHKYVALYATHLIKENQIHKALDLYVQHGAPANPQNYNIYKRLVMELLSNPHMNQAEAYRNWADLRDVLLNLCDHVAKSSDANTAQHEEFEAMLTIAHYYATRSVCMGTQNLESLAARLSISLLRHTDIIPADKAFYEAGMHARSQGMLNIAFVFLNRFLDLTEAIEEGSLDMLDNTDFQDTDIPFEVPLPERQHVPEDKKEEVKEWVLAVSMDQQVEQCLDHDERDTYVASLIAANTNIQSLPCVITGYPVLRNKLEFKRPGKAANKDDWNKFLMATKMSHSPDCQDVLKFIGQWCGAAPNQSYTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMA4</accession>
    <name>A0A8B7YMA4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Somatostatin receptor type 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110980983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093792.1">
        <property type="nucleotide sequence ID" value="XM_022238100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMA4"/>
    <dbReference type="GeneID" id="110980983"/>
    <dbReference type="KEGG" id="aplc:110980983"/>
    <dbReference type="OMA" id="EEYCILW"/>
    <dbReference type="OrthoDB" id="5950040at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="63"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093792.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44273" checksum="C2F9146267A6C24C" modified="2022-01-19" version="1">MDDAESYNYHYGELLPKLTDGECAFMKFFNITPEIIGDFTYTTRQKALLLGVLPLLMVIGLLDNLAFVYVVLRIPEMKTVTNSYLLNLAIADVLYLTFSVGEKLIKYGLSPVSDDDGALGLGGCIVIYIISDLAYFAGLFFVTLVSFDRFLAVHSPMASGRKGGRNYTQIAIAGTWIVAAVLAAIMSPSYGALEEYCILWPDEAPYNEWSHVAAECMAVEPWLMPFTQGLQTLPFFISFVVNVILYIFIIKGLDQSIERLRKHGLMKEKDINVRNQIARMLVVNGLVFFCCLAPFEIRSLLKMIDTLSGGDKIVIPLETSITLDHIGRVMAYTNSAINPLIYTAMSSRYRQAFKQAFLPKNRQGFFRGVRTSFNQTLSHTTETHMDETHTESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMU4</accession>
    <name>A0A8B7YMU4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110980972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093770.1">
        <property type="nucleotide sequence ID" value="XM_022238078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMU4"/>
    <dbReference type="GeneID" id="110980972"/>
    <dbReference type="KEGG" id="aplc:110980972"/>
    <dbReference type="OMA" id="DWLVYQS"/>
    <dbReference type="OrthoDB" id="10447394at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093770.1"/>
        </source>
    </evidence>
    <sequence length="186" mass="21234" checksum="DE2EA98FDECAFE43" modified="2022-01-19" version="1">MAATSFHTVCSHFNHSNHPGDTRILKPSFRFHSTTLFIMRGDTFFPGLLLIASLVYLTVASPTSRATQEHRHADIVVLANQLPWELRVLYDIIISPSTDEIRRENYIWRAFELLKYKKYKAYVWFYDWLVYQSGYDGRGPGRHTPRGGPGGRTHRHGRGGPGGRTRGHGGPGRRTPRGGRHHHGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNV2</accession>
    <name>A0A8B7YNV2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear pore complex protein Nup160-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110981590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094944.1">
        <property type="nucleotide sequence ID" value="XM_022239252.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981590"/>
    <dbReference type="KEGG" id="aplc:110981590"/>
    <dbReference type="OMA" id="TLWKNNM"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056547">
        <property type="entry name" value="NUP160_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056535">
        <property type="entry name" value="TPR_NUP160_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23345">
        <property type="entry name" value="NUP160_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23354">
        <property type="entry name" value="TPR_NUP160_120_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="61"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 helical" evidence="5">
        <location>
            <begin position="571"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 middle TPR" evidence="7">
        <location>
            <begin position="858"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="6">
        <location>
            <begin position="1171"/>
            <end position="1428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022094944.1"/>
        </source>
    </evidence>
    <sequence length="1433" mass="160268" checksum="8590A0FD179ABCDF" modified="2022-01-19" version="1">MAEPSSFHEVTLLRSESPRCKELTISTGASQGVLQDVNLPDCAGGYAYRESGRVTSVNRNRFIYWRTSRDVLELAEVSLDHNLTGNTVSLHLQDAPILPRITLHETNSHMIILVATINSVHRLVLPHPNRLPRHDVYSRNSSLPSIFADVSIASIRDAANFHVIGQGGSAAYEFQTSSSWLTNDGEVMFALATNTGSVVLVKLPPIGIQGIVTQHELKQATVMQRLWTGLVPAAMRRGQESLDSTTSLTLHPLNHDLFAFCACKDHKVRMWSCKSQSCVLTVDLVDYIPTSSGLTDQSVTRHEIRTALGSDQRTLVLGFYLSFTTQSQFLILQPVLRDGQYKLIQVALLNDDQQNTLVDFGLTLSTLWAVWNSPSGETVVKFTTYEGISVGERSWNSVFMEPFHTPDIIVPPFLEPREAYLDNIFHPGKFSLQSVSRALNIYSRSSGGAYTPLTDPTLLTPELLHEEVTTVMEVELQQKVGGSEMSQEEYREVVEQSWSRFYTCCVQYHEVASKPHGIMLDPNTGMVCLLKKNLLSLLRPCDAVEHLYLAPPRGVSTQDFEAVPFVITEKTLCRDLITLRNCVKMISQTLSPEIKMSFEHDVYQLEKPDLIAQQIAGDLLGESMDSTQVPSISFVQQLTSQLQSLQDPVRAVLTLLNAMDLAEGNPMSLMMEEGAVGDSVEHLSSRQLFASSQGVAVLAASFVQMSFTRYQLLRDLLILECAMVKLGDQASLSSEALDDLESDIICETASCLLAYYSLFWVGNCVASTVPANSLEANLRQFAALEISDSTAGLALSLSQAQSLDKALTPTLAELFLEGIGGSQMRSKVNQDGYMKKNECEVWMEVLRPCLTALAQMVWPISGSFLFPEFLMGKCQYTQLQEYIRLLNPWCDWNISSRHFLLGHCLLNSGEPHKALACFLRASHRIANEDFLLNKLLLTEELTGKKLDILYYLKVIRLLEQFGLPDLVISLANTALSVADDDDPNVPTLWSKVFKYHLELGHNDEAYAAMATNPDPERRRDCLRQFVVVLCQRGQTKELCQFPYIDLHDEVVSIMESRARSVDLLTTHNYYDLLYAFHIFRGNYRKAASAVYEHAVRLGLEVPSLDGLRKQAKCYLAAMNALELVNQDFAWIIKPVAVDEPNAEDVVGASPKRNYDGEILQQQVRRQVKVIELCDLRKEHQLVDARLKLANHDPESIHSSMGPMLSADETVSLLVQSGLFDVACAVCKTFQLDLTPVFEGLATKCVKLSLNGLNETAWKWLSMNDLGTLHPSRELGPADLAWQLLKQYLEKHDRVGDHTHYKCVINKLLSLGYHLPTWLLLAYKKLNPASLLLLYITYDMLEEATSLALEFIDAVCGKGSEYFGLKTSLRATLPSVWLPYQSIDHLLTALKDQTDPTLKQLHSDLKDKLNLYHANVEAVSRDMIQIRSLGTNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQK7</accession>
    <name>A0A8B7YQK7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Alpha-2,8-sialyltransferase 8B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC110981874</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095552.1">
        <property type="nucleotide sequence ID" value="XM_022239860.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095553.1">
        <property type="nucleotide sequence ID" value="XM_022239861.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095554.1">
        <property type="nucleotide sequence ID" value="XM_022239862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQK7"/>
    <dbReference type="GeneID" id="110981874"/>
    <dbReference type="KEGG" id="aplc:110981874"/>
    <dbReference type="OMA" id="SIEREWG"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23963">
        <property type="entry name" value="GT29_ST8SIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF52">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-POLY-ALPHA-2, 8-SIALYLTRANSFERASE-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022095552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022095553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022095554.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43344" checksum="B60E4B01FA03C488" modified="2022-01-19" version="1">MRMSLARFCTVVALVSLVVIISLANRHFFGRRYAQDAAVHSVHRSHHPAGMRIGTPPKATPEMIEVPPRDEDNPPTERLIPVSLHCKQVCTSGLGGDCYPIDKAILVYRDDTPTSFMKFRQNAHPVLYVSKPADGQTVPEFQEVEECDMDDHFPDMFLLPRQRQCAVVGNSGILLGSGCGKAIDGHDFILRANLAPVKGYETDVGQHTDMTAINWETLGRLYSSVVQSGPTNLDNRILLERIHRLQKSILWYPKSLSKLYQREVIRKLAVTLKDHKFMNIKMAFGWKAISIEREWGLEGYATLGFDMFVVARTLCSNITLYGFYPSREGPNGEKIQHHYYEDVDFKYQTAKHDFWLEYQKLQDLQAKGEIKIQIKPCKTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YR48</accession>
    <name>A0A8B7YR48_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 2J6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110981983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095753.1">
        <property type="nucleotide sequence ID" value="XM_022240061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YR48"/>
    <dbReference type="GeneID" id="110981983"/>
    <dbReference type="KEGG" id="aplc:110981983"/>
    <dbReference type="OMA" id="EFNWADH"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095753.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59527" checksum="B60FED2B5E158C50" modified="2022-01-19" version="1">MSMISQLGWMLASVTPVHVLLCGVVCLISWWWCRQSAAGLPPGPWGVPVLGLLPRVFLEQRRGSHPHLLFTEYARHYGPIFSARIVNKTLVVLNDYDSVRQAFQNPNLSDRPPSTLIAEAMKSEGVAMASGEPWKDLRRFCLTVLRSFGVGKSSFEEQIGAEGRALVQTMTSYGGHPFDPKYLIGNAVANVICSVVLGKRYEYSDANFSYLMRVFHRIVNHVGSGGLLNAVPVMRVFTRNKADVYASFGEFRSFILSVVESHRATLDPKNPRDFIDVFLNEIETNEKAMSNGTIQENGSTSTSGFVAKKSIPPNGLPRTHHPHLSDKRIVGTIGNLFAAGMETTATTLLWALLYMAAYPKIQERVQAEIDAVVGRNRLPVMADKPELHFTQAVLLEVQRIAVVTPLGIPHAAASDTEVLGFKVPKGSLLVSNFWALFRDPNIWPEPDKFKPDRFLDKDGLAFKPEELIPFSTGRRSCIGEHLAKMELFIFFSYFMHQFTFEKPDEAPPYTFEARVGLTHYPVPYQIRALQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YST9</accession>
    <name>A0A8B7YST9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110982325</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110982325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096354.1">
        <property type="nucleotide sequence ID" value="XM_022240662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YST9"/>
    <dbReference type="GeneID" id="110982325"/>
    <dbReference type="KEGG" id="aplc:110982325"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022096354.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="12379" checksum="761494CB5C49F03A" modified="2022-01-19" version="1">MGESVKETNVTMWRKTVEEAKTLLEEICEWSQLSCKTQRFDFSLTKKKAKQVWLDGLDILNRMSESNRGACLETMWQWARNNYGCNDDGSLQKPSEYMVIYGVKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTM3</accession>
    <name>A0A8B7YTM3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-crystallin SL11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094701.1">
        <property type="nucleotide sequence ID" value="XM_022239009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTM3"/>
    <dbReference type="GeneID" id="110981211"/>
    <dbReference type="KEGG" id="aplc:110981211"/>
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    <dbReference type="OrthoDB" id="10029479at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094701.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="24165" checksum="24774082AF4EE62C" modified="2022-01-19" version="1">MPSYKLLYFDTRGRAEATRMLFALAKQEFEDVRITKEEWPKIKPTTPQGHIPVLVVDGKELPQSAAIESFVAREFGLYGSNNWEAAQIDVVLETLKDVIDPMIMPVMFERDQAKQAENAKNYYENVAPHHLTNLENLLKKNKDGNGYFMGDKASLADIIFFVTMGWFETPPFANKGLEHYPKLVALRDRLATNDLAKYLAERPQVYWIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUJ1</accession>
    <name>A0A8B7YUJ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hsp70-Hsp90 organizing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110982198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096150.1">
        <property type="nucleotide sequence ID" value="XM_022240458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUJ1"/>
    <dbReference type="GeneID" id="110982198"/>
    <dbReference type="KEGG" id="aplc:110982198"/>
    <dbReference type="OMA" id="ERGNDCM"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF532">
        <property type="entry name" value="HEAT SHOCK PROTEIN STI1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022096150.1"/>
        </source>
    </evidence>
    <sequence length="246" mass="28051" checksum="A0A256A1F4FDAAFD" modified="2022-01-19" version="1">MNKEKADEARERGNDCMKQGRATQAFFYYTEAIKLNPSDHRSYSNRSLAFLKIEQHYHALEDAKKAIQLKPNWPKGYFRKGEVEFRTGHYQDAVNSYEKAISLDESDLKLKSALEKAQEEVKKMKAAAIRIPFISIGIGFLIGILLTLADHYLTSKPSLEGYVKLAFVALFGMLGYCGSWMYFYVLTTYHDAMLQPPPEQNDADKKTDKSTDPETSKGKRTKPSQESAKKDKATGEARRRKKTEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVM0</accession>
    <name>A0A8B7YVM0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110981780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095361.1">
        <property type="nucleotide sequence ID" value="XM_022239669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVM0"/>
    <dbReference type="GeneID" id="110981780"/>
    <dbReference type="KEGG" id="aplc:110981780"/>
    <dbReference type="OMA" id="ERNTECC"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="455"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="650"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022095361.1"/>
        </source>
    </evidence>
    <sequence length="765" mass="81077" checksum="59BF6686A03A00D5" modified="2022-01-19" version="1">MSSDEDENVSLSPEEKLPFMVLLAILKNEVARGKQLLEEHDIDVNFFLPVSSRRRTMLMFAAQYSPGMCRPLLEKGADINLAQKETGFCPVHFAAERNAESCKILLEAGADVNQTDKDGATPLHLAAEVNSPSIPILLAAGADVNAYESENMGGGQPLHRAVKKSPEACKLLLDAGADVNAKRACEWAETPIQIAVITAPQCCQVLIDAGADINVKFARFHKGFTLLMYAAFDSPEVCRALLEKGADVNLAHSERGIFPLLCAAERNTECCKILLEAGADVNQADNHGSTALHAAAQRYPSAIPILLAAGAKVDAVESEDIGGRQPLHYAAQHSPEACKFLLDAGADVNAKRLSEEAETAILIAASKAPQCCQVLIDAGADVNVQFNLSGCCPLHEASHEDDDPSVCQVLLQAGADMEIKDQTGKTALHIAAELNEAVCKILLDAGAKHDCTDDEGNVPMTMAAVGDNVKAIQHLLDKGASLEITNKLEESPLNAAAKMNSTKAIALLIDKGADVLSRNWIGYTPFHMAASKHPDATKVFLAKGVDIEVRATNGITPVFSAAKENVECLKLLLEAGADINARIEDGSTPLFASAEGRNSEGTKLLIEAGCQVDAQDEDGLTALHTAARHDVDSCKLLLDAGARIDIASKEGTLPQHSAAASGNAKSLQYLLDKGAAVDAVDKLLCTPLHYAVMNNEKCVRILLLAGADATLKTVIGLSAYAMCMQLNPDKKILATLLGKGKPKSTDDSDSTEEEESGSSSSDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWZ9</accession>
    <name>A0A8B7YWZ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucose-induced degradation protein 8 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097849.1">
        <property type="nucleotide sequence ID" value="XM_022242157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWZ9"/>
    <dbReference type="GeneID" id="110983156"/>
    <dbReference type="KEGG" id="aplc:110983156"/>
    <dbReference type="CTD" id="54994"/>
    <dbReference type="OMA" id="KMILWAQ"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022097849.1"/>
        </source>
    </evidence>
    <sequence length="227" mass="25946" checksum="0D79BDBFC06A7D37" modified="2022-01-19" version="1">MASSKTLEITQEAWLDKLQSLHITRSDMNKLIMDYLVTEGFKDAAEKFQQESGTQPATSLDSMSERIQIREAIQEGRIEEAIALVNDIHPELLDNDRYLYFHLQQQYLIELIRNGQLESALEYAQTHLAERGEENAEILPELERTLALLVFENPETSPFADLLHPSQRQKVASELNSAILEAESRESVPKLANLLKLLLWSQEQLDAKKVKFPKMKDLAKGEFQGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YX19</accession>
    <name>A0A8B7YX19_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane-associated transporter protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110982019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095831.1">
        <property type="nucleotide sequence ID" value="XM_022240139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YX19"/>
    <dbReference type="GeneID" id="110982019"/>
    <dbReference type="KEGG" id="aplc:110982019"/>
    <dbReference type="OMA" id="WKEWKNG"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="685"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022095831.1"/>
        </source>
    </evidence>
    <sequence length="711" mass="77066" checksum="AC00BE4ADB8EEDE6" modified="2022-01-19" version="1">MVSGRVSSACSRFWTSTKSLIQDCMPRRVLDDVEPIIAEEERQAVAGRLKSRLRLARLSGAVCGIEFCYAAETAFVSPVLLRIGIPPRFMTLIWCLSPLLGLFLMPLLGSASDRCKSSLGRRRPFIILLSIGVVFGLLLVPYGWPTGRVCDVSAYRQMDKKNVDAIQWSNATSEAAIRTTELPIRDALIKELEEILSSQLEYKNSSQSAATEGMSVGDVFNTSPTHLSSVVTSVPALPKAIRFCGMALTILGVMMLDFNCDAAQSPARAYLIDVTDPADHAKGLATFSFMAGLGGAIGYAIGGIPWGPATDDDPVSLQVRVVFSIVLFIFVLAVLLTVTAEREQTLYELFPQEKRRKARETKRALDGGYEKVNNARPTEVAEKMEMGTMKQKVKTYGSNAPNPEIVTTFVENKDADANEELASGHSLANGSVKVGKQAVLGEAGDKNKHFNKEEGDAESDWSSTGGDWDEEPPTITIGTYLLSIVFMPWSLRILCLTHLLGWMSLLCYSLYFTDFVGQAVYGGDPTAAPASVERLRYADGVRMGSFAMAMYSITCSICSYNVDRLINKIGARPVYICNHLIYSISMVILANVRTVWAAFLFSACAGIQYSTLFTLPFVIVAHYHSSNVFETPSSCCESGTRANQASGHTVRGLGTDIALVQGMVFVAQLALSSCMGSIVQAFDSTVVVVVAAAILSFLGAIFASQVTYAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY53</accession>
    <name>A0A8B7YY53_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096186.1">
        <property type="nucleotide sequence ID" value="XM_022240494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY53"/>
    <dbReference type="GeneID" id="110982194"/>
    <dbReference type="KEGG" id="aplc:110982194"/>
    <dbReference type="CTD" id="8030"/>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096186.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="49690" checksum="7F39154DE0042E68" modified="2022-01-19" version="1">MADMADSASASEIESDTDSMKMCIPTRKEELLNRIASLEQENRVLKIELETYKMRCKSLQGENRDLKRASVNIQAQAEQEEEFISNTLLKKIQALKKEKEKLAVNYEQEEEYLTNDLSRKLVQLRQEKHQLERTLEQEQEYQVNKLMRKIERLENDTVSKQKKLEELRREKVDLENCLEQEQEALVNRLWKRMDRLEAEKRMLQEKLDEPVSAPASPREIKNGSTTDNLSVYVDQLRNEVRKLKGQLMSAQIEHQEKMAHLVQEEREFKEENLRLQRKLLLEQERREALSRHLSESESSLEMDDERQFNEMAVHGSLRPRTISSPIPYSPNPNRPISPAMHTAFSPSSPASRSTPFAVGPPSHPSPISPYGTSPPVGPSHLMHMGSTPPSQGQQMGHPSQSQLHRHRVTVATAGSNSGSHNPEKFIKPTAPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYD6</accession>
    <name>A0A8B7YYD6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ectonucleoside triphosphate diphosphohydrolase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110983083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097702.1">
        <property type="nucleotide sequence ID" value="XM_022242010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYD6"/>
    <dbReference type="GeneID" id="110983083"/>
    <dbReference type="KEGG" id="aplc:110983083"/>
    <dbReference type="OMA" id="FMLNFTN"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24044">
        <property type="entry name" value="ASKHA_NBD_NTPDase1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="308"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022097702.1"/>
        </source>
    </evidence>
    <sequence length="629" mass="68463" checksum="764565118C2A2FC0" modified="2022-01-19" version="1">MQIMVRAAIGAQVTSVPIEVDPKWVIKSVIVEFCQKIDIPVTGDIEMKDDSGLILNKSATIGEAGIHNGDTVFISHSEPEGDAEQQDVFVRRGMERSQMYSIVLVCVGFVLVTASICGIIALAMRFTEEICSDEGYGAVFDAGSSHTNLTIYSWLGDSRTEGTGVVRQEGTCRSPGGGISSYDDNPQDAGPSLISCLDYTKQVVPEQYYNFTSLHLGATAGMRLLEKTEPSTSTLIMESVRQTMATYPFNFTANQATIISGSDEGSYGWVSANFLSGTLNPGSTLSSAIVSALSADPLPTVGALDMGGASTQITFIPEDPSSLPPQYSENLRLYGVNYTLYTHSYLCYGVNEAIRRFKANLVKDSGYAKMTVNPCAPKGFRETVDGKYLWEAPCSKGPQALAGWGSEVLPSPNAVNITSFNLSGTSDLDSCRTAVAKLFNFTAPCPIEPCSFNGVYHPKPYGKFLAFSVFANLISDLDLPSDASVQHIENTTKSFCAKTYDEVKKMPGNLQLLVLYCFDLTYFSTLLLRGYKFDADIWKITFTNEVKGKELGWSLGFMINATNMIPTEASCTDFTKVGFYVGLAILIVTFVIGLIVLVIAVYRCTRPKRESGYEELNPDFARKNTYGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYP3</accession>
    <name>A0A8B7YYP3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110982338</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110982338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096361.1">
        <property type="nucleotide sequence ID" value="XM_022240669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYP3"/>
    <dbReference type="GeneID" id="110982338"/>
    <dbReference type="KEGG" id="aplc:110982338"/>
    <dbReference type="OMA" id="QCDEGVE"/>
    <dbReference type="OrthoDB" id="6083617at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF44">
        <property type="entry name" value="PROLINE-RICH TRANSMEMBRANE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022096361.1"/>
        </source>
    </evidence>
    <sequence length="152" mass="16755" checksum="7B3E7BF6D66024EC" modified="2022-01-19" version="1">MSSSYRPLTSQCDEGVESAEMFFQPRSGQSLLSMPSFPQAETTVITSRNQPKDYQMLALFVTLFCCLPLGIMGLIKSSEVRRRAVIGDSFGAHQASYRAKSLLYAGLGVGLLLWMCSLTAFVVIAVQVFSENKLPDKSFKYHFVTAIVPIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ85</accession>
    <name>A0A8B7YZ85_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Vesicular integral-membrane protein VIP36-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110982443</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096521.1">
        <property type="nucleotide sequence ID" value="XM_022240829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZ85"/>
    <dbReference type="GeneID" id="110982443"/>
    <dbReference type="KEGG" id="aplc:110982443"/>
    <dbReference type="OMA" id="GCTADIR"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000017">
        <property type="entry name" value="Vesicular integral-membrane protein VIP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="13">
        <location>
            <begin position="32"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022096521.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="37881" checksum="28ECB75A54364B21" modified="2022-01-19" version="1">MAAPRLILFCATFHIVFIHFYAFVVCQDNPADYFKREHSLMRPYTGSGASLPMWDMQGHTMITNNYIRLTPDRQSRQGAIWNKVSNRSPNWEIHVEFKVHGQGKTLFGDGFAIWYTKERMQIGPVFGNKDFHTGLGVYFDTYSNHNGPHNHPHPYISAQINNGTLHYDHDRDGTHTQLAGCHAPFRNRDHETHVAIRYLSGRLAIMTDIDGKAEWKTCIDVSGIKLPTGYFFGISSATGDLADNHDIISVKTYELEGADKSVDYASLNPSADFFAPPRDHVDDPGGAFRGGWTVSLKNMFLLIFCCVLGFFVCLIVGVLIFQKRQEYNRKRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0M1</accession>
    <name>A0A8B7Z0M1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC110983506</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 30">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022098502.1">
        <property type="nucleotide sequence ID" value="XM_022242810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0M1"/>
    <dbReference type="GeneID" id="110983506"/>
    <dbReference type="KEGG" id="aplc:110983506"/>
    <dbReference type="OMA" id="HATSWIN"/>
    <dbReference type="OrthoDB" id="3256376at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 20 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="131"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="26">
        <location>
            <begin position="222"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="317"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="550"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="694"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="557"/>
            <end position="564"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20 22">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="712"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022098502.1"/>
        </source>
    </evidence>
    <sequence length="858" mass="95210" checksum="D3A6C2BA92034765" modified="2022-01-19" version="1">MPAMGLVPNDRLDSPNRPSFRRWATILLSVHPNSTVPVGTSITLTCRVDDAVYGTVVKWYLNDVRVFGYRVGIIHPNDRYREDAPTAGTWRFIILSAHPEDSGKWRCQSVFPPTRSQRSARAQMELRIGVPRIVSLSKDIETTLGSRVLLYCNVSAEPDASITWNKAKPQQSLPTTASTNPVTSALSFRIVTVKDGGVYECVATNILGTVVGRVAVNVIHVPLIDSALSDDRVVSWINLPVNLTCAWSAYPTPRVSWDRSGVMVDQTRVKTFTMEGISVLQVTPTTTDFGVYRCLVANSRGRAEHIVSLTAAASPSAPGNVRAGAITHDTVILLIDPPRTNGGLALTNHRVSYREANMVRWKVLEFPIGQNTIIRGLKPHTEYQLKVAAGNPVGFGNYSDVVRISTMKQYTSGDRMTTLLPYPNSTYSTSGIGANNDSSSQSADTSNTTIATDMKPGSQGPSPFAIVVGTLVAVFLCCVVIFLIVSLRVYLAKKKRPTEEQRLCRNRPNSIFSDASLFQLRHDSVQYDVMPMTCGPGLLRGEFEFLRYKLVFGTVIGTGSFGKVIRGEADGILRQGVKSVVAIKTLKENATSNDHQDLLKELGVMKILKPHPNIVTLFGCCTAEGEQPPLIIMEYLPNGNLLQHLRSSRQRVEDTETHRASIRTTMSPTDLIRYAYEIANGMTYLASMMCIHRDLAARNILLSRDGVCKLSDFGLARDVVNGGIYQRKTQGRVPIRWMALESLLDNVYTIQSDVWSFAVLMWEIVTIGSYPFPGMSSKKLIKELQRGYRMARPDHCSGDVYDIMLDCWRENPASRPTFENLRNRLEAILIESRNYLVLDFDEHLYDYTYSGSSDGVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z160</accession>
    <name>A0A8B7Z160_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110983515 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110983515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098510.1">
        <property type="nucleotide sequence ID" value="XM_022242818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z160"/>
    <dbReference type="GeneID" id="110983515"/>
    <dbReference type="KEGG" id="aplc:110983515"/>
    <dbReference type="OrthoDB" id="6115758at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022098510.1"/>
        </source>
    </evidence>
    <sequence length="1189" mass="132261" checksum="9360D5CE02F8124E" modified="2022-01-19" version="1">MTTAPVATTSVLERIQATVALLMLDLRVVIDTEDATDQKCEQRGLCSDLFCLRRAVVSSCSNDTGQGTLNTYPEPEAATNYNVLRPLPTLVELCLPKIACSGEYMKLWAPFPPGLQPLMRALRNQQWLQQLRFSWLMKAIEEAERAVKDHIRPLSSSQCSEGHLLFRRHTRHRDSLMGWRQNPDLPYGPDMLALPEPVDGYDASDWCIAVVAHTIDMLLPTTMSEPVVTETVSALCDHSAAMAANVDSVRCLLSKWAPKLAQHCFDAALVYVWWSRGHIERAKQLLLQLLNHQIDDMVASSANFPETGLQIGLYLNELGRMMTHADQPELAGQFYRDAMEFAQDGSPLSINSSRLQSLALCAAAYDQGMMNQHYAVRAQSLWYSVLCEPDCPPELTQAAIVSLLHCHVSFSSQENVTKVDADKLWLKEMAAKLHDISLKDPSAYFYLSAVWAFLGKNDEAFEAYVNYSAYFSQTRGTEVPGSVVKSGPGSNQHYPWWKVSEWLASKSTATKDRNGRAFMCMPLLWRRNLGHTTCILGNQTSKRCVGDVCGVMPHFCITRDGFLTGCIMGNLPPMSNFLLNPHTGRPCASDHGRQLDLLKWDNFHSKQEGIQPGLRSVLFDASRAAFHVPCSGFLDSSYPCGFRIDTYLPTPIHLLTNRRTGDVFSLLVSNNIVDYNRHISKQDDWEFSVRFPAISHHEAVLICTSSLKNLKIDLRSVIVQAKRDAVLRDLGNNSECSSDYRRMNEAKILLQILVKHKCQIGVFLAQDIADNRQGSQVSKLKLALQRENLESLKDFLPPPQTIRVSNVLFVGENTAILSLLCAISPYNSQEDNTLVFADCDTANTFRNPVVHFTSSPDKSWKLPDQFVDWKSVGTNKKVFFVYESVISTRNDCSGEAKTLIVFDELGGILMKEVSNGRKTSGPHGCVNFFTCCGWNLLGFNYSRTGVISYNVRTRTTRTVRLPQVESLQVAGSVILVAVPAGVVALESINLLPLIVSRVNHFPVPLGTNTDEKTHSDALVVEGDSRFLQILTSSGLTDGLAQYSNRDEKRHSTRAFLGLINRVVILEISTESKALSCSNCCPLPTTLTVTADVILAGIPTELCFISQSVGFIVTTTVSKERHPLETEMMYWFDMSGNMRGVHPLLGPGPHGMTAVPLKDPDQGESLSEVQSLRWHLFFDDGLGGICCIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1Z7</accession>
    <name>A0A8B7Z1Z7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110984115</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110984115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099633.1">
        <property type="nucleotide sequence ID" value="XM_022243941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1Z7"/>
    <dbReference type="GeneID" id="110984115"/>
    <dbReference type="KEGG" id="aplc:110984115"/>
    <dbReference type="OrthoDB" id="6116165at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="76"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="156"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="235"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="5">
        <location>
            <begin position="317"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="420"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="4">
        <location>
            <begin position="768"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022099633.1"/>
        </source>
    </evidence>
    <sequence length="884" mass="96180" checksum="25501F23EC984BB8" modified="2022-01-19" version="1">MCPDDLIRYTDVGRANTTVTLPAATTSDNSVTSLTVTTNPSGSPVLGIGNHTVTYTVTDDSGNPASCNITVTIRDEERPNLICPANITRHTDEGQSFATETYSPLVLSDNDGNMPNLTSDHPGNTFSIGETIVTLTARDLSGNEINCSFSIIVEDNEDPRLMCPDDLIRNTDVGQANTTVILPAATASDNSMTSLTVTTNPSGSPVLGIGNHTVTYTVTDDSGNPASCNITVTVRDKEPPNLMCPANITRQTDTDQSFATETYSPLVLSDNDGNMPNLTSDHPGNTFAIGETIVTLTARDLSGNEINCSFSITVEDSQPPALECPSEVIVYTDQLVFPLQFSGYASWTINVTDNSQMPLLRNESTHQSGSFFNTSITNVTHTVVDAYNNVNQCSFCVIIMGFVNTICNPSGSDLDLSELAGRGVRYHLLSPNFNISETYPSNSDCTWRISAPAGTHIRVRFEAFDTEFGKDVLTLGNGLDFALINTSLARYSGKLVELVNGTHHTKDRVYGNAIWLHFVSDQTFVQKFFGFWLQFDYISDPRSLYPASHSFCSEFDGFPCLDGSCVNISKRCDGVANDCPSNEDETDCPQVCSGSLPPQSANFTADNGVYYTDIVSDNYPGEYRPCNMRWNIDSNFVQSVRIVVMDIQIGAQDRLYIVDQGTGNAVTSDIDSLVSLHITSSTSLAVIFESSGGAQHGFWIRVWRYIPGRNDFLDFPAYCEKALHGVLCGTGTSGIATCFPDTERCDGDTDCLTFNNDERDCQAASYDCGNTTISLGNQGSMYHLTSVNYPADFLYGISCRYFVTTTAARILASFRDVEIPATTSNDYLRIGNGDTVSDATEILRVTGVFLPQDVVSEGNRLWFEFISDSSVNSRGFWIVLVAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2S2</accession>
    <name>A0A8B7Z2S2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110983066</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097671.1">
        <property type="nucleotide sequence ID" value="XM_022241979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2S2"/>
    <dbReference type="GeneID" id="110983066"/>
    <dbReference type="KEGG" id="aplc:110983066"/>
    <dbReference type="CTD" id="23397"/>
    <dbReference type="OMA" id="FRKTCAD"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="569"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="586"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022097671.1"/>
        </source>
    </evidence>
    <sequence length="732" mass="80411" checksum="5EAC7F440DA16B82" modified="2022-01-19" version="1">MPAAVDVHTPAQRGAALFRNPSSVTTPTDFISPSTSSRRHPPPLPGQSALHGQHVSVPENDDAAERRQRRRSKVLEMQRQFQSPGTPSDRRRSLSLNQGLSAAQITDHYANCIKLSTENKINAKNAFGLHLIDYMAELLKEKTGEMTNFQVASCTLDASAKIYAGRVDAIHADTYKMLGGLGHGDRQSKEGEEGPTEAGEGGTNTNKKQKKRHSNTVESNLKNINLNKLDLGFEMDPLFHKTSAAFDEGGTFGLLLNHLTCRDDEGELLLDSTTMASSVGTQTDEALESARQARLDLSDLRDVYAGVNLDALQICPQFADFEFTNWNKDGKDDFAAMIEQMGKSDQAFDVNAVPEPLDEPDAGQPEFGTDHYTAGGFSDCDDDCDGGEGVGSIGEASVFMADGQEARLVGSSGCRTLSTAGQLCLQLSLQPTEYSYFNMDKLTTWAGPQHWKLKPHSKDPSSLGNGEDDKKAKTKKPVFRIDYEEDVNFDKYFSESKAATTLSKATLDKYSKSVTTLPGDLHYNPDSLFKLFLKPNFVVRRQVSNNDSMDDGIGSYDYNNANDCANFCPDTGVDDEDDDHGRSGDMSSGPSDFSQTCSQSSYINDSVFDATLLQGDRLVAQPHKVAKIDIQYARTAKKMDVKKLKSLMWQHLTADKEEDKENIPSETDANKKTSVAGEQCFSDMYQVLPAKLSRTMAKNLSIPIAFVCLLHLANEKSLQIVNNEEDLVITQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z396</accession>
    <name>A0A8B7Z396_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Spermatogenesis-associated protein 17-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983984</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099432.1">
        <property type="nucleotide sequence ID" value="XM_022243740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z396"/>
    <dbReference type="GeneID" id="110983984"/>
    <dbReference type="KEGG" id="aplc:110983984"/>
    <dbReference type="CTD" id="128153"/>
    <dbReference type="OMA" id="LHTTSKY"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099432.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="42283" checksum="A35F854E08E842C7" modified="2022-01-19" version="1">MATVVRLLERTPSIMEQVFERNRIAEEQRWLEWKASVHIQAWFRAVRVRSYLKHLHGCATVVQRHWRGYLGRAFVRVLIRNQVLIMRQNFYNAMATIIQKMWRGFYTRKYISNYYSRKRYLEGLLVKNEIVRQELEEYSEQKNRERAIEMEQTMQQMIIDDARKHHYLLSTQVVPGIYNSPFKPYPDEMEMILRGVQPRPPPGPKPKRDNRSGKVIPPSPPLPLTEPLPPIGESKLQGPFRMPEEVIKQRFKPLQPTLRVATSYTSVEEAREAMKAKEWVMRVNDNIFEPFTRRDRAYDPLLHTTSKYGHLPYGTRYFRETEEAKNITAMRFQPVVSPIPVFEKLNDTYSKGTETVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4X7</accession>
    <name>A0A8B7Z4X7_ACAPL</name>
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        <submittedName>
            <fullName evidence="10">Krueppel-like factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110983446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022098396.1">
        <property type="nucleotide sequence ID" value="XM_022242704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4X7"/>
    <dbReference type="GeneID" id="110983446"/>
    <dbReference type="KEGG" id="aplc:110983446"/>
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    <dbReference type="OMA" id="EESWSQH"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21973">
        <property type="entry name" value="KLF6_7_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF166">
        <property type="entry name" value="DENDRITIC ARBOR REDUCTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022098396.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32535" checksum="79D0F92CB4E821A6" modified="2022-01-19" version="1">MDVFPSGDIFQELKVLHETGCYSALPSLEEHWHQNCLEMERYLKAEPCQTQDKKIKEPENPWNKFILSCQQVIREKEVESLLSLSDSESNDSRFDLDTDTLSLSSSSGASWDSSGELSPSPTATVTCDPFRAEFKAKVSTVTLTPPSSPEITRVMPVSMPVNQLVAVSMVHMDRTTVRVRSVNSARSLGKRAESPDSKRRIHKCQFPGCRKVYTKSSHLKAHQRTHTGEKPYKCTWEGCEWRFARSDELTRHYRKHTGAKPFKCNSCDRCFSRSDHLALHMKRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5K8</accession>
    <name>A0A8B7Z5K8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M-phase phosphoprotein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100918.1">
        <property type="nucleotide sequence ID" value="XM_022245226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5K8"/>
    <dbReference type="GeneID" id="110984751"/>
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    <dbReference type="OMA" id="GSMKKKF"/>
    <dbReference type="OrthoDB" id="20403at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019324">
        <property type="entry name" value="MPP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13582:SF0">
        <property type="entry name" value="M-PHASE PHOSPHOPROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100918.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="19337" checksum="1845CF5FB763D6E2" modified="2022-01-19" version="1">MANDRRDCGSGKTKLSKNLMQMKFMQRTQESNAQKEAEEAEQRRHNDDTHWFLDLPEITAKESKFEVEPSFAVCENLKFGRMSFKGMNPSIEKLMRSMEAEELEAKSEQREREMTVSDEEMARRYSTLVGTIANKFTKKRHRTKAPEEPQEKRAKREFRKPPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6Z6</accession>
    <name>A0A8B7Z6Z6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DnaJ homolog subfamily C member 17-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110985030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101418.1">
        <property type="nucleotide sequence ID" value="XM_022245726.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110985030"/>
    <dbReference type="KEGG" id="aplc:110985030"/>
    <dbReference type="CTD" id="55192"/>
    <dbReference type="OMA" id="MRHVSGV"/>
    <dbReference type="OrthoDB" id="259708at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12429">
        <property type="entry name" value="RRM_DNAJC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034254">
        <property type="entry name" value="DNAJC17_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="9"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022101418.1"/>
        </source>
    </evidence>
    <sequence length="398" mass="44608" checksum="0C4A39D70EE3E3AA" modified="2022-01-19" version="1">MAPDISEKDLYEVLGVLQDATVSEIKKAYRKKALTCHPDKNPDNPRAAKEWEELSKALEILADSEARAAYDKVLKARKANELRNRALESKRRKVKEELEAREAAFREEQDRSKGRDAAQQLKAVIKRLQEEGSRILAEEQRLLKEELQREGSGLRQEEDDPPRLKLKWKSKKSDDTNGGYSYDVLYRTLLKYGPITNLLVSSKKKGSAVVEFGTSRAAELAVQNESGLSTNPLELSWLSGQPKAATVAPSSSAQPPNSNADDDFESLVLQRLKSAGRQQRCGGQHAEEDKDVRQSAPQDGSRTSDFAAKEQYLRHTEDIASVPEDLLTSGDRAETVCSQEGSILQEGRPDRDCDTFKTSNSGRTEARDYESLALRRMRQVAERQKLIEQMAREDAGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7E6</accession>
    <name>A0A8B7Z7E6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tripartite motif-containing 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110984648</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100720.1">
        <property type="nucleotide sequence ID" value="XM_022245028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7E6"/>
    <dbReference type="GeneID" id="110984648"/>
    <dbReference type="KEGG" id="aplc:110984648"/>
    <dbReference type="OMA" id="CETCCEL"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="94"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022100720.1"/>
        </source>
    </evidence>
    <sequence length="544" mass="60197" checksum="05D878FF8EDDD1D1" modified="2022-01-19" version="1">MAEGVTQRSILTKFGEEHLQCSICTDLLRIPKTLACLHSFCEDCLCQCQRSQRTIVCPLCRKETASPKGGVKKLATDFKLASMIEAVAQDEADQTIPTCSAHAGRKCVVFCETCCELICLTCLQESDLHRKHEVGEVSQETVLAKKRQFMKEHQSKCDEYFKENVTALETAGMLRKDLEETVTQAQKAVEAKADEEIAKIIAAKEFLLNQIDEIKTGRERQLSGFTEELVFRNETLQQMIHHSQKALKTYNDYVFLRGFSEVSSSFKVLADYPHPRTDRIVHGLQFSPAITTGAVHLGSLLTRDGGEWKLRAETSHSASEGGRGVTVRHDGTALVADVWTQRIFEVTSGEILATLKSMKTCPRDVSVTSHYMVVVDDTAFVKMFALDKSVQNFQFSTVPSCEVETTNVDLQSVAINGCGNVVVGDVKRNMLTEHQPSDGVIVRELPLDTPPEFLAINSESQALVSSEYSGVVKCIHQGRTAFTIMPTIRGTKVRCCTGVSWGKDQVFYVAMHNKASGTGQVHLYGASGQFLKCIIQGLHFTPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7V5</accession>
    <name>A0A8B7Z7V5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110985200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110985200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101738.1">
        <property type="nucleotide sequence ID" value="XM_022246046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7V5"/>
    <dbReference type="GeneID" id="110985200"/>
    <dbReference type="KEGG" id="aplc:110985200"/>
    <dbReference type="OMA" id="MEIHPWY"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19135">
        <property type="entry name" value="AKR_CeZK1290-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF10">
        <property type="entry name" value="ZGC:110366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022101738.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32785" checksum="C31D9A3D123C8A48" modified="2022-01-19" version="1">MDAEMEHLQLSNGIQMPVLGIGTSRWFVGGYSDEAMVYALGHCRVRHIDTARRYRCEDLVGASLRKSGVTREQVFITSKLWPSEYGYRKTRAAFQDSLQQVGVEYFDLYLLHYPSSPEGTDTKQLISESWKALEEFYSQGLCKAIGVSNFQISDLKNLEETWNVVPHVNQLEVHIFNYPEKLIEYCRRLGMQIVAFSPMAKGKALAHPRVMELATKYKKVTSQILNRWVIQHGCATIPKSTKCHHVEENCKIFDFVLTEEDMQTLDAIHETEPYTVLPVPSRAVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7Y9</accession>
    <name>A0A8B7Z7Y9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc finger protein 878-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110984833</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101067.1">
        <property type="nucleotide sequence ID" value="XM_022245375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7Y9"/>
    <dbReference type="GeneID" id="110984833"/>
    <dbReference type="KEGG" id="aplc:110984833"/>
    <dbReference type="OMA" id="DKPYMCC"/>
    <dbReference type="OrthoDB" id="7852576at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF243">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="466"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="495"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022101067.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="59477" checksum="794232377AE994E0" modified="2022-01-19" version="1">MKYIKNNTLREYVKEELRVSLFQMAHKLAIQTGCEILVKLEDCADHSGCQYYATRTLNLQYMDKGLSKQPWEVMVSGITGLPVSNHGDQSEDQNGSFAETEEYELSTDGHDAEMDTSAELSFANNLPSESPANMAVVNQDSEQGGQTVVHVIKTEPGNSQLTTSADEESWTKTTVTLPFPVSLESALSSQHGAGGLDANSQDQSMDADQIQQQIYIYANTNTEEKGGDLGGTAVEDEGADDNTDPQRRRTPPSLNYQCSLCKKRVSSVPLLVRHAKMYHPGDESMRYHCVPCDREYKHARHLEQHTELHSKASYRCSTCCKGFYRSSTLREHELRDHQGRYRYYCPKCHKGFMRPSTMQTHLSRSHPAWFSKSKVSPRIVPKTSKILDSLPRIIIPVKDGEELSSLCTVTASEAVPSTSGEQGQMTQASGQNSVGAVAHSDSETVQTTVSENVQNQTEKKMMKVMYQCKECGRMYDNANSLVRHIHDRHDSRTKLRCNQCSYRTSRTSDLARHKRAKHPFVVATQSANSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z950</accession>
    <name>A0A8B7Z950_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985464</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102194.1">
        <property type="nucleotide sequence ID" value="XM_022246502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z950"/>
    <dbReference type="GeneID" id="110985464"/>
    <dbReference type="KEGG" id="aplc:110985464"/>
    <dbReference type="OMA" id="IMSAEFD"/>
    <dbReference type="OrthoDB" id="10356532at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102194.1"/>
        </source>
    </evidence>
    <sequence length="428" mass="48190" checksum="6CAB38CAA437BC9D" modified="2022-01-19" version="1">MSRSNSKACPKFRSNQNLMDDLGVFEEICTCNWRPGLVHRAGQIATPEFCTSTHQAWSTPLAGWFNSLPLGILRPSPPVSIDRGGRSSTPRKPATNNSKLARSGQTPTKPSTKSAGNQRAERNEAPFKHRQETSEYIKEYREKNVLRLVGSDGSRINDGNLAFGKTLPDPYAFKSEEFRKMYSRLREYLMKRPKRQHAAGVPLAEQHRFASPPSENTAEKEQPTSQFSISDEVRTNFSDIFSPTFQRPKVDMFFRPYICGSGSIQTPAKLRYSHSADRTGSLPSIHREPDAVQFPMPAYVVTESGNFYQEDKIGSSSKLGVATPMDLRLLEPKSASGSRQKSNRGKTKPNIMSAEFDTAMIQFLQKAKQNLERVREERIKKESLDKCRLMSRRGKKNDFVVTSGKQRTVKSNTTVTDVRRIKLGVSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBR8</accession>
    <name>A0A8B7ZBR8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110984616</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110984616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100666.1">
        <property type="nucleotide sequence ID" value="XM_022244974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBR8"/>
    <dbReference type="GeneID" id="110984616"/>
    <dbReference type="KEGG" id="aplc:110984616"/>
    <dbReference type="OrthoDB" id="10058436at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022100666.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="25095" checksum="78E5F0CEAAADC633" modified="2022-01-19" version="1">MGIVLGVEAAVGVAEAVEAGAAAAEAGEAVAGAAEAGEAISAGAEAGAEAGGEAGAEAGEAAASGGKALSQIVERIGVAMEKLNKMITEYVAIDAVFKAARAILEAITSDPAAKARAEKLAKLIDVLTSCSSLMQDLYNWLKDHSNDTTTLQGIDVPLSGILSKFLPKIGAASGVLQSLSKQVSAKNLKKEPVTDGEVDALRHGLDTVAQSFQALVAFKDENVAKVKALAGLPINDSKVAAITDKLSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEZ6</accession>
    <name>A0A8B7ZEZ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110986560 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104209.1">
        <property type="nucleotide sequence ID" value="XM_022248517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEZ6"/>
    <dbReference type="GeneID" id="110986560"/>
    <dbReference type="KEGG" id="aplc:110986560"/>
    <dbReference type="OrthoDB" id="5971833at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022104209.1"/>
        </source>
    </evidence>
    <sequence length="768" mass="85655" checksum="1C65E57468C42C16" modified="2022-01-19" version="1">MDKGVAVEEEPLTEDGDTPRKAAPLFLFYSCKTSGSSFMKHKLLNLAIHCWPYDDHAPVFFRRINHMDRGKGLGKGRAQQPVKGQKSGSSDDDITRTPAAVHVIEELLQWIDSTVDKASAASGLALYPVLIAHWGETFQFLFLFRMLEKYGIDALETLGAHNVHFADPVPTLKQYKDARHPWLIDSRSLGLGSLLNDWFPAQFHERDLYFSRSCGALVLKLYTQSPLYWLLYRVPIFNTQEWVDFYKGEKLYQEDKWELQENLPSRVVGLQRKLTVKQLLKHGYSWSALIDLYKSCGSPHHFRQELRDIDVKTGPASQITIALAGMKLEQDGSREYKVRIKSNMQYVKYYHLTDPRGRHFILRVANVLPPIFFKLSDLCDNTWQVPDNLLRIGPPETWNAMLDLAPRDENDNYRDENVLKGLLNLPSGDSSEGEWDKADEDNGYQTFSNSELPDCYFREPAPAHVPTTLVKGVGATNPFAFPEQDWLAVDSWNQTPESDSTKGENCSSRSPASGKQLASAKNAVPASDANSVDLCNHTVADQQPQRLCKSLGTNCRNCKKSRRSTAGNHSNCKPAVQSKYSTSTNQRDSSEPYHSTSSSQTNRSEVNSSKLYLGPSNQSSCNSSQTFTKSNNSTSSSARHSVRSHQSITSTQVAPQRGTPDLSSISSSEFSHDGPHHNQGAVPKKKGCPPPRPQSKKKSRQPAQANEAAVVESPPCAAANHGPANGYRRNGHSSTSSEAPRDEVFHAHKSAPARTQSKNGRKQARHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZG45</accession>
    <name>A0A8B7ZG45_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110986760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104628.1">
        <property type="nucleotide sequence ID" value="XM_022248936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZG45"/>
    <dbReference type="GeneID" id="110986760"/>
    <dbReference type="KEGG" id="aplc:110986760"/>
    <dbReference type="CTD" id="22948"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000028">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000049">
        <property type="entry name" value="T-complex protein 1 subunitTheta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022104628.1"/>
        </source>
    </evidence>
    <sequence length="455" mass="50441" checksum="09DE85F368FA363A" modified="2022-01-19" version="1">MDIPSQLKIRSIVAFGEIGPRTEEILAGALLEQAEALLDRGIHPIRIADGYEMAARKACQRLGEIKEAFEVNQDNLEPLIETAMTTLGSKIVNKCHRQMAKIAVDAIMAVADFQRKDVDFELIKVEGKVGGKLEDTMLVKGVVIDKDFSHPQMPKEIRDVKLAILTCPFEPPKPKTTHKLDIKSVEDYKKLKEYEAKKFTDMVEQVKATGANLAICQWGFDDEANHLLLQNKLPAVRWVGGPEIELIAIATGGRIVPRFQELTAEKLGRAGIVRELTFGTTKDHMLVIEECHNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLVRDNHIVYGGGAAEIACALAVSKEADKISTIEQYAMRAFGEALESIPMALAENSGLHPIQTLADIKSRQIKEGNPRLGIDCMGRGTNDMKEQHVIETLIGKMQQINLATQLVRMILKIDDIRSQVGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIU8</accession>
    <name>A0A8B7ZIU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein BTG2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104942.1">
        <property type="nucleotide sequence ID" value="XM_022249250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIU8"/>
    <dbReference type="GeneID" id="110986923"/>
    <dbReference type="KEGG" id="aplc:110986923"/>
    <dbReference type="OMA" id="SHWFPDK"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF22">
        <property type="entry name" value="BTG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01203">
        <property type="entry name" value="BTG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022104942.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18901" checksum="5254D534C57AB0EE" modified="2022-01-19" version="1">MKAEVTCAVHFLMNFLRSSRDMEQQTLRLERFSQILINLLCDHYRSHWFPDKPFRGSGYRCLRINDMLMDPLLAKAGQLVNIALEEMQLLLPSELTVWVDPGEVSYRIGEEGSICVLYDGATETISETKLSALDLLNCKMRMHNQNTSRQRTADFNRNDVTVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJC6</accession>
    <name>A0A8B7ZJC6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Inter-alpha-trypsin inhibitor heavy chain H3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110986944</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ITIH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104985.1">
        <property type="nucleotide sequence ID" value="XM_022249293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJC6"/>
    <dbReference type="GeneID" id="110986944"/>
    <dbReference type="KEGG" id="aplc:110986944"/>
    <dbReference type="OMA" id="LLVIRHM"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030212">
        <property type="term" value="P:hyaluronan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000013">
        <property type="entry name" value="inter-alpha-trypsin inhibitor heavy chain H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010600">
        <property type="entry name" value="ITI_HC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050934">
        <property type="entry name" value="ITIH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10338:SF108">
        <property type="entry name" value="INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06668">
        <property type="entry name" value="ITI_HC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034295353" evidence="9">
        <location>
            <begin position="25"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="VIT" evidence="11">
        <location>
            <begin position="68"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="10">
        <location>
            <begin position="331"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="665"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022104985.1"/>
        </source>
    </evidence>
    <sequence length="961" mass="106451" checksum="09D97BE4BD4AEB7B" modified="2022-01-19" version="1">MDSLRLTVASLFLIAMVASPIAQAAPAFVAAPEFETTEEEQVVLHREERQAGSGGGSGYSNYYVSDDEDYPTEMRPTRVYKPDIHSFHVEASITARFANTLINSKLVNDKEFPQEATFAVTLPSEAFISKFVMVIDDVAYEAEVKEKETAQREYNAAKERGQTAGQVKQHETRPNTFRVSVNVASYSAVVFNLTYQELLQRRHSVIEYRLNIDPGQVVRSLNVDVHITEPQGLQEMDAMWLSTAVDSGSTNDVISPLQDVVYLDKMSQNRAHIKFHPSKDQQKMERANGIIGNLLVQYDVLHDLSAGNLQVMNGYFVHYFSPEGLTPARKNVVFVIDVSGSMGGTKMDQTKEAMRTILADIREGDRLNIVTFTDDIDVWQYEGMADRTDETIQQALQFVGRLRALYGTNLHGGLMTAVDLLKTSALVDRQDQREAYSMIIMLTDGLPSSGVTNQNQIRDDVKEAIAGQFSLFCLGFGHDLDHDFLDNLASENQGVARKIYADGSASLQLKGFYDEVATPLLFNVNIEYNHVNSTTQTNFLSYFEGTEIIVAGQLSNELMLHESGLTELMATVTANSMDTFIQLETMVDIQTPASAVLSRHAVDDFCQRLWAYLNIKSLLKARKISRDRQEKEDLKARALDLSLRYHFVTPLTSLLVVRPEEIDQVPSPLEGEAGDSQAPAQDTLTSSSQSVSRPQSSPSNQHAGGSASRQGHSPAGSQRSGGGGGGYADSDPHFVVHVPTSDVTVCFDILGQAGEVFNLLTDAQLGIQVTGFIVAAPEPVPGTDRTRTYFGRIGIRLGRHTVKLSTKDVTLDGNMVLSWKNSVMVERGNWSLAVHNKEAVLTRNDGAISLAIMLHRMNPDIAFKVDHLGFYIVNHEGFSGEVHGLIGQFQRRQIQVKPQSEPKDGVVAELTVMDRRVDVVQRSRLNNLVGRKQPCWYVKDNAHGLIDGPHTDYLLPPEMMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJL9</accession>
    <name>A0A8B7ZJL9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110987093</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105217.1">
        <property type="nucleotide sequence ID" value="XM_022249525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJL9"/>
    <dbReference type="GeneID" id="110987093"/>
    <dbReference type="KEGG" id="aplc:110987093"/>
    <dbReference type="CTD" id="4724"/>
    <dbReference type="OMA" id="GTIMKFD"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022105217.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18611" checksum="67BA55435DAB957E" modified="2022-01-19" version="1">MALCRCASRSSNVNIFCRFLSTSPWRTLKEGVQETRVDTLKEKSMDLTTVSGIPEEHIKTRKVRIFIPAKNAMQSGTNNTHQWKLEFETRERWENPLMGWASTADPLSNVALSFRTKEEAASFAEKNGWWYEIEELPSRAMRPKSYGANFSWDKKTRVSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJM3</accession>
    <name>A0A8B7ZJM3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987011</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105080.1">
        <property type="nucleotide sequence ID" value="XM_022249388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJM3"/>
    <dbReference type="GeneID" id="110987011"/>
    <dbReference type="KEGG" id="aplc:110987011"/>
    <dbReference type="OMA" id="ANERTTH"/>
    <dbReference type="OrthoDB" id="6044186at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695:SF12">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105080.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16206" checksum="29E3B929DA2FEDA3" modified="2022-01-19" version="1">MTPYKYTYVLSDVELGTHFRVDFTLRAPRNGNLALSSRRGDQDSGIIYEIIIGGYVNSKSAIRRCKLCDKGQIEVSTVGIVSDSEDRAFWIEYSDGDVSVGRGEAPPMINQTWSEAEQGERPSTVYLGVSTWRDASGHWIFQNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZL13</accession>
    <name>A0A8B7ZL13_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Coiled-coil domain-containing protein 18-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106313.1">
        <property type="nucleotide sequence ID" value="XM_022250621.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987679"/>
    <dbReference type="KEGG" id="aplc:110987679"/>
    <dbReference type="CTD" id="343099"/>
    <dbReference type="OMA" id="SKQPWES"/>
    <dbReference type="OrthoDB" id="2160759at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875:SF8">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18875">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-24/CYTOSKELETAL PROTEIN SOJO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="710"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1015"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1448"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1497"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="778"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1115"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1025"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1448"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1511"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022106313.1"/>
        </source>
    </evidence>
    <sequence length="1623" mass="183748" checksum="0A3DA5662C78A4BB" modified="2022-01-19" version="1">MTSESDTDGDLLLKNVSNIRKRLLHTERSLQMLQTPRDDTRYAASSDGDSLADETLQPLTLDDLSEDYLDIRSSDRGIRFPYSFHRDAVAMQGAHSTQTPGPEQQLKMNGSVQGSVPSTHDFENESLRKKLQALRDENSELVSSNHQLLNKLESTEYELRSTKTQLQAVSHELESTKGEVPSLRDRVAKLESSIRLDDEALRSADQKLVEYERELQEKDSLIRQGREETKTVRSELTFEMQQRRRAENQRDEAMKNLEDLSDQLNEYRNKTKEKFKKYQSTEDHLRDSLLHCDKEREELLEKATALEEELQDSRENFRVLREESARDLEASSQDLQSTISGLRHQLDQLRGELDTKGRENAELTELTQRQNERLADCQRDIEASHSELKRLEEMARKLQAQMRSSGDSSLTLNNGYDVPRPVRTSSPNSDPGQGTHPGQWNNSPAPSALSADQAHNTTWSDDVDSGGIVGAGSNRALIAQLKMKLAMKEAENQRLQAARQRDSAGVSLASSGTMDGLRSELTALVEKNKIGDRKAQELRGIINRLEEERTRHAGRLAQLQERLTEQEAHSTAVESQLDHYNAQLKILQDGITQKEKQVSTLEAELGKKNGLVAHLEEHLSEKTASIEECTSKLTELEQLLEEKMSELRELQTHLERKTEEAEQTGETLTKVKELHAQQCEEMLQQIESLLESKETLSTQLENTNLSIDEAQGELTTQRNHSKQLKEELDKTRRDLEDKTREHSEATHSLQLQVKDDAYRISQLEAALVVCKEELTGYIDRLDDMRDRHDKELQTKKSEIRKLEKQLEQARDQQAQSAEQVSELERALEERQQMLLQSTARLAELEDKEGQLEHQVSHLEKGLNHVTVAAEKDAALIEKKLHQACMDLEDRTSQLTEATQALSQAQADLAEADTRSADLELQLSQTKQDCDNHAAKATQLEGELREAKLQLENMTAKVSDLEGALETIRQENQAHREQSLELDGELNRAQLEVQTATKQLSELQRVLQRSRAEAKQKQQRMQELTDELRRSQNEARNREQDMAEMDEALKSSQRELQQRATQVSQLDTVVKEHRSEADQKILQLENSLSKSQYELKQCSRKIGELDDRCGEQQETLKERALQVQQLEQLVSRQKNEIGHKAAEITQLQKRIEELSQQCSSHREEELAQGQQLRLTREQMQRHHLELAEARRQLAQVQREKLAHLQESHAALLASKNQLEASHRLEISRLKDAEARGRQEAESLREKVTGLENELQARKEVIQAANEAIVIKEAEVARLNARISGYERATFGTQFTTHEPPNHSSSATPSRGIAPYLIPPLVAPSSPLFKSPRIVLRRSASDHNLPSSGIGVDAGLRNSFRDMHLQTGSPHRGNHSRHLTDTGYHSLGLYGSRDVQEPMVGYEPRDVHSRNRVMKEPASLGHFSDTDSAEDAENLETLQGMLAFVNRHIASQQQQDSAAHSHSPNPNLSSLTEHGHSLIGLTQEDSELALSLSEIQDVGGERWGSPSKGRGGSRTSAGSRGVSPSSKSPDRGRTQGHQPKIMKSTNGSPKILPLKKRLATQRAKLVSGKPSKETPLKPEDCMADLQDRLRANDERRRRIDDQLYNMRDHARKITNRILGKDPDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLA4</accession>
    <name>A0A8B7ZLA4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105832.1">
        <property type="nucleotide sequence ID" value="XM_022250140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLA4"/>
    <dbReference type="GeneID" id="110987419"/>
    <dbReference type="KEGG" id="aplc:110987419"/>
    <dbReference type="CTD" id="25873"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105832.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12809" checksum="F9FD22E3DECA238C" modified="2022-01-19" version="1">MSTHMAIRHDMCVGLNKGFKTTKNVAKPKKKGPRKHVKFVRDLVREVCGFAPYEKRCMELLKVSKDKRALKFCKKRLGTLRRGRRKREEMIAVLAAQRKAQAGTSQAQAPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMU3</accession>
    <name>A0A8B7ZMU3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Uncharacterized protein LOC110987704 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC110987704</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106381.1">
        <property type="nucleotide sequence ID" value="XM_022250689.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106382.1">
        <property type="nucleotide sequence ID" value="XM_022250690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMU3"/>
    <dbReference type="GeneID" id="110987704"/>
    <dbReference type="KEGG" id="aplc:110987704"/>
    <dbReference type="OrthoDB" id="10157181at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051713">
        <property type="entry name" value="T-cell_Activation_Regulation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25466">
        <property type="entry name" value="T-LYMPHOCYTE ACTIVATION ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665730" evidence="12">
        <location>
            <begin position="20"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
        <location>
            <begin position="195"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022106381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022106382.1"/>
        </source>
    </evidence>
    <sequence length="761" mass="85376" checksum="37FC5780623EBC98" modified="2022-01-19" version="1">MPLYEISSSAMFILMMVRALQWTTDIKISPSHGLIIDPVDANDTDRYWCKTVRASSSQFVEDYLDVTVLDETFPEERDSIVSETSESMDIQSRNTIQCPLLPQLPTQTDFTVYWTIKNSDGQSLNIIAAKFPNGEIISVQEFDETHSLTGKNAMQVGRFSKRQEKYCCHVFEQDNDLRTACVDVTWLAVATKMRPTIKGCMPTSDDCAIEVTPHQECLQLECSINAVYPKPTLNWSTSGCKEPAIYFTNSSVDRTSELFNVKSTVYIVDLNKSLELCSTFTCTAQGEAITDQTQTSFIMISRKCIYIDAINNITWLAINENTRELTIRSSQTHSFLHFTGQKETTTPSIATTCICPSCNSSGCGVELFFAITLLLIFLLLFLLLLLPRSKRFILTCAGVMPTLPRYPHKCAVRRTANEPAFEPTEANTQSQSAKDVDCQLEVTVPLMTIGAKDEKSADDKEGPVCFVNRSNQDVDITDPQFTWQYKGELTTESVLDKKYVSGFQSIKYVICMEDSGVVVIDITGLHQYTDEYRYRFVDLKRAFGNIDYACVTCFTKTKLIFGLKWGKLVIFDTSNEHLTNFASVTPVKGRGVELESIAVGSSGLVFASDKNGKAISIFDQEGVCLERCEIPSIEPRCLAAYVRNEISSFFVTAETVVRKYNITGQIQSSINPKHQFDIDKQFLGTDFKPIHISVKEETLFVVNQLDDVESLQILPLNVIDRKFQRSIIANAPGIRGVRLSSGDKVIVYSDSSVHLLEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPD3</accession>
    <name>A0A8B7ZPD3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Syndecan-3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987997</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syndecan proteoglycan family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106912.1">
        <property type="nucleotide sequence ID" value="XM_022251220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPD3"/>
    <dbReference type="GeneID" id="110987997"/>
    <dbReference type="KEGG" id="aplc:110987997"/>
    <dbReference type="OMA" id="DNTMRIM"/>
    <dbReference type="OrthoDB" id="10044468at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001050">
        <property type="entry name" value="Syndecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027789">
        <property type="entry name" value="Syndecan/Neurexin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10915:SF1">
        <property type="entry name" value="SYNDECAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01034">
        <property type="entry name" value="Syndecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00294">
        <property type="entry name" value="4.1m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033988645" evidence="11">
        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Neurexin/syndecan/glycophorin C" evidence="12">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106912.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="37634" checksum="E54230082CD6A818" modified="2022-01-19" version="1">MRLFVQIWMILALFLVEKNVVKAADEDNVMYIDGSGDGGEPGNVAEAGTPDDEDNTEVPGEIGSGTVGPGTKAAGDLQTLKGTASVKLSFDNTIRITKIGNRRANFIETYRDPNSVESLEVFNQVCSVLTSSNQLTSRAESCVGVSITEGSLVVTTKLTFPEDTEATSAAVESAILESVTDQTALTVDLRSITVEPSISEPEGTEVVEPLEPATKPKPKEPDTPSPSRPNKGNQDNDIFFTATTDKPAHSGGNATVSNEINDVNHDNSLGVKNEKEKEQDFFEMILGNPVLLAALVGAVVLTLITIILIIMFMIYRVKKKDEGSYSLDEPHKVKDPTTYWKDTKEFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPV5</accession>
    <name>A0A8B7ZPV5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Estradiol 17-beta-dehydrogenase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107618.1">
        <property type="nucleotide sequence ID" value="XM_022251926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPV5"/>
    <dbReference type="GeneID" id="110988439"/>
    <dbReference type="KEGG" id="aplc:110988439"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF50">
        <property type="entry name" value="GH26015P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107618.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38801" checksum="A262196038B66305" modified="2022-01-19" version="1">MLSTTVCLSACLVLIITCFSWELSMRNILIGLGFSAFVAYLRKYVGPNLLQVEKQSVFITGCDSGFGHATAKHLDALGIQVFAGCLFPGGEGASRLRAECSEKLRVIPLDVTKQEDVDAAIATITQSIGNEGLWGVVNNAGICLWSELEVTPMETIKHHLDVNLLGQIRVVKATLPLLRKTRGRVISINSVNSSFYMPLFGAYGISKAATEMFCNILRLEARKWGIQVITIHPGSFRTALTTNRYGMRQYQRKCLEQLTAELKQYYTPGYFEATLDVINPSFIPTDVSPVCRTVTRALLERVPSACYECGLLAGTLINVARWLPTPLFEFLIRNSRVFNIEPNLNPDLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQH3</accession>
    <name>A0A8B7ZQH3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110988457</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022107649.1">
        <property type="nucleotide sequence ID" value="XM_022251957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQH3"/>
    <dbReference type="GeneID" id="110988457"/>
    <dbReference type="KEGG" id="aplc:110988457"/>
    <dbReference type="OMA" id="ETECAAC"/>
    <dbReference type="OrthoDB" id="10045177at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679:SF2">
        <property type="entry name" value="C-TERMINAL OF ROC (COR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47679">
        <property type="entry name" value="PROTEIN TORNADO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="11">
        <location>
            <begin position="46"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="10">
        <location>
            <begin position="1013"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022107649.1"/>
        </source>
    </evidence>
    <sequence length="1084" mass="122343" checksum="DDF7B7A626B32832" modified="2022-01-19" version="1">MWSRSGKSDPETVLAPISDFNRSIHLTTLLKDKSLRESYATAQTDGQLPANRARVLILGEPRAGKTSLLNRLLDREFDVREQPTEGIDTRMCQVTNVDKQWKETGGAKSDDIQHCASLVTVLGEVSSAYGTTESKEVGGNNKDTPTKPRTQLDLLKLGLELFCLFLVVFVFEVFQYGYVAFVWCTFVALSLMNNYNFAYRFATYVSLFCVLFDAVLRRERLLEESSGEECADDLQNRTIWPALGNMMFDSVNYVILGAATGFGCRTGVAVAFSASVHPAETEATRGVEGGKWDRLVLTLISGAGALLGVGFYIFCTFSDRWHKYRAALCCGLLALILALSSEGDCRHRRFWFLFLNGIVVSAQSTWGTILGRRVSHKYGLRASYVSKKVAGLIFGLYLSYVCGWTMRIPGRSLSCVALYILSVLSLPLFDLHNTFKIWRAKSTFPVKLIREQMKSVLQGKPVLETKLSLWDFAGDTLYHCTHHIFMPDRALYVIVFNLQAAVSDEEGQLQKLLFWLHSVCAHARHPDAVVIIVGTHKESVSEASRTRITNELHRRIASPFCHRLVVNSLNDKPLFLVENSQPVDEDFKQLRGEIFRRVESAEYAQEKYPIKYLHFYREIQKHRKRAEKDCAANVVTVDQIGDLAMNTCDITKDDDLESMLKFFCEAGEIIHKNNDNVLHDYVVLDPQFLVDVMKKLVHIPRASRRSHRFAVDWINYENSGIITEGLLQHIYGDMCHLVPLLTKLLQAYDLMCPVTPDLNPDSSQKSFLVPAMLPPYRGEPTEFWKPTKKDEVFYFDFGFFDPSTVYYRLLTRCVVKASQDNTKFGSLPMSFADRSRFYFGSSCIFKLQLEKSSHQMLLSVTVLAFEPENPSTNLLKDLLEFIRSITARDYPQLSFIFGPRCPYCGPELDFGTSNEDIFGGKCGNSTLDGAKIHVLKMAGHDLPFPTVSPVPLFCGQHRYELRLPECKPSDASHGRTTRPRRVSFGPGTVITKLPPDIFERVCLLLNNAAMIRNWKTLAGELGKDVESVVALDSEKVSNPTECLLREWAAIGGEVTVGDLLEVLGRPSLERMDIIHEIRTQMTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZR39</accession>
    <name>A0A8B7ZR39_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110988390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107532.1">
        <property type="nucleotide sequence ID" value="XM_022251840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZR39"/>
    <dbReference type="GeneID" id="110988390"/>
    <dbReference type="KEGG" id="aplc:110988390"/>
    <dbReference type="OMA" id="HGVSSKW"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013288">
        <property type="entry name" value="Cyt_c_oxidase_su4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01873">
        <property type="entry name" value="CYTCOXIDASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022107532.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="18448" checksum="99ED6613B6CE8C8C" modified="2022-01-19" version="1">MAVNMLRITSRRFAASACVRSTSTLPYADRLDYPAPPCRFVPEADLSSDMQALKAKEQGDWKSLTLDEKKALYRLSFDKSYSEMRAPTSEWKYVIGGVFGLLAISIFFYGLQKKFVAPPLPRTMTKEWQQEQMKYNIAIRNNPVTGLASKWDYEKNDWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRA6</accession>
    <name>A0A8B7ZRA6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110988329</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107415.1">
        <property type="nucleotide sequence ID" value="XM_022251723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRA6"/>
    <dbReference type="GeneID" id="110988329"/>
    <dbReference type="KEGG" id="aplc:110988329"/>
    <dbReference type="OMA" id="IHACANN"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107415.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30468" checksum="00A94F0696E75565" modified="2022-01-19" version="1">MTQLHVPPFFFQQDLEAGKQYTICISTVLYNVSLNKEAVLRDQCREINTKSLSISEKGISVPVMVTIIACVILLLFIIMTVALFVQRKCLKQKVIPVRGLRNGATGNSVNWERDIPSPRTNDSTLGDEYDTAKVRLPITHNIEAFRPIKPNTNPFLSPSPMHSFTNDGNINESHYGNLFQSNNSQVIMLTQQTCVSHGSSVPPDVADTSPSCSAAHIPQCTPSRRLQRIGSVPPANIRALPVTISNHVMRSANARDMDASGEFDLHRTYFFPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRZ9</accession>
    <name>A0A8B7ZRZ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol phosphatase PTPRQ-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110988458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107650.1">
        <property type="nucleotide sequence ID" value="XM_022251958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRZ9"/>
    <dbReference type="GeneID" id="110988458"/>
    <dbReference type="KEGG" id="aplc:110988458"/>
    <dbReference type="OMA" id="WDDIECS"/>
    <dbReference type="OrthoDB" id="5969272at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034752549" evidence="3">
        <location>
            <begin position="23"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="135"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="237"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022107650.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="55451" checksum="3F456FFF9FF7AFA3" modified="2022-01-19" version="1">MASEKPAIAMSLMLVFVLPVLPEVNATGQVQNLTVVNVEGTPGAVLVTWVPPESPDSPVEFYRVSYMLRIEAQCNTLNNPSPVVAAELATGTSYTITGLLPYSNYEAIVEASTGTGLQGEARAWVQTPEVAPTDPPRGVRLLKHASGGTYLAFTWDDIECSIGTMSSAFRSYYFELNSVDQPNTAPITGQAIRGPKLIFDLLPFHRYAFKVAIRSQVGDGPFSDPLVVRTEESSPSIPADFHANETSETSVTCTWEEPRNPNGVITNYTITLRPSNRPFDLSFVPPLSATEIRHLGPNVFSSRFTDLEPGSYYELSAAAWTSYGAGTIDIVETFTWPKMDILGPSLPVVDPYASNDTSVTISLEDPDDYYVTSYLVAVESDAPRSKRSPVEIDGRAFGTFSNNPHAYIAAEIPKGENTGSVVVGDGKMYGGYLNVALVKGTLYRIRIGSKSAIDWRSSVFWSPTLKETAGAYDFLPTAPMSSTPSKGHSISQQWMLGAVPWAVFLSMWLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZS82</accession>
    <name>A0A8B7ZS82_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein YER152C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106311.1">
        <property type="nucleotide sequence ID" value="XM_022250619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZS82"/>
    <dbReference type="GeneID" id="110987676"/>
    <dbReference type="KEGG" id="aplc:110987676"/>
    <dbReference type="OMA" id="MIALDSM"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42858:SF1">
        <property type="entry name" value="LD15494P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="1">
        <location>
            <begin position="116"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106311.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="54200" checksum="BA508B4AE1943081" modified="2022-01-19" version="1">MARYIQGGLCLSQRAQTTFTRPGRHCFASLPSILPVPSFATNLPVLFCARSLRSTSSSAMADYIAIKKRRTEIQESGPFAENDFKCRGLFSGLNQQLTIGGPGPDRLRRVAELLSKAAHKRMAEEALGDGDLLQYGNTGGDPLCRLELAKFLSKGYGSPVDVQDLMLSGGATQAMAFLLTFFFNAGDTVFVEDPTYFINLNAFKDYGIKSVAVPLEKDGINTEALEAKFKEFAANDQQEITATRPFRAMFYAITVFHNPTTICYSPEKCRRVVELARKYDILVVCDDVYNVLSWMHSGNNEIGLAPPRLVSYDRKEDSDYKGNVISCGSFSKFTGPGLRLGWFETAPHLLDMMRKCAYMVSGGNFNTFTSGLMGSALEMGLIENHVANLRKTYSASARALWKTLQAELPEGSRVAEPMGGYFIWVELPEGAKAAEILKIAKEDYKVAFLPGNLASPCGNFSNCLRISFSYYGDDDLQTAAKGIAAATRKHLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSY4</accession>
    <name>A0A8B7ZSY4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110988973 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110988973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108693.1">
        <property type="nucleotide sequence ID" value="XM_022253001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSY4"/>
    <dbReference type="GeneID" id="110988973"/>
    <dbReference type="KEGG" id="aplc:110988973"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00276">
        <property type="entry name" value="C2B_Synaptotagmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF374">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="467"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022108693.1"/>
        </source>
    </evidence>
    <sequence length="608" mass="67583" checksum="6F2CB2C6E8870D71" modified="2022-01-19" version="1">MSMSTGGIVAVVLVIILILIVTVVLVVIKCRNQSPKYQPWKPTEETGGTSKKPDPSPTGPRSRTSSSRSPLFDRRQTPAPHLVIPLASSTPNVTTIHIPVSGTRHHSDTDSDSSSSTSERDEERLQDDVDQATDGLLHSAERTSDDALAEDGDINSKTPQGVGLDRGGTSSSSDDQAERDADEEGSASCTLSPAHSAPEISVVQVMSAPEMGGSSRNKSTLESDYEETAYSVYRQKKEVLQTPSTAMPHEQEHTTVVDNHLPPAEKKKKRKRRGISVPHMPYRHHTKGEGRGGALLLHEQAHTLHKGHSGSVGSLTNLGEPMGKLFIRVQHKASEEKLLLFIDKVADLDLPERLKYRQSFNPALYIKGGFLPSMGQRFITKYAALAEVKDGPWSVTNVSWRNEFAIMGISKSAAWQLTLRLCLCFRESSINRIQIIGVCDIALGQINLENSQDVVLNFFPSERIYFDLGDLHLSVCYQPSLQRMVFLVLEARDLPRSTVFGSIHSIAKIEMMCDRKRVEKQKSKVVRETHNPIWNDQIVFTIPPNNIKLQDIQFDVTVLHVDMVKGAHVIGKCELGWSATCEELQHWNDVMQNPNRPIPMWLSLQYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZT23</accession>
    <name>A0A8B7ZT23_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside diphosphate-linked moiety X motif 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110987821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106616.1">
        <property type="nucleotide sequence ID" value="XM_022250924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZT23"/>
    <dbReference type="GeneID" id="110987821"/>
    <dbReference type="KEGG" id="aplc:110987821"/>
    <dbReference type="OMA" id="FRHTHNM"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04670">
        <property type="entry name" value="NUDIX_ASFGF2_Nudt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000015">
        <property type="entry name" value="Nudix hydrolase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003293">
        <property type="entry name" value="Nudix_hydrolase6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040618">
        <property type="entry name" value="Pre-Nudix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994:SF13">
        <property type="entry name" value="FI03680P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994">
        <property type="entry name" value="NUDIX HYDROLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18290">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01356">
        <property type="entry name" value="GFGPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="112"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022106616.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="32021" checksum="9127E9D72570410E" modified="2022-01-19" version="1">MDSNSVQTSGLIENANNLLQGVADSFGGVKVTLAAEQWSSVEDFGKRLEDSVEYWKSLCKRGIWLKISLQETELIPEAVKHKFVFHHAQPSYVMMIRWLPSDEPNQLPGYSHTYIGVGGFVTNDNNQLLVIKEKYNHGKKPMWKLPGGHSDLGEELAETAKREVLEETGIKAEFVSILSFRHQHKYRFGLSDIYFVCHMKALTTEITACPQEIEECKWMDLDEYLVNPEVSDFNQKIARCFVQYRDGDPKPSIQPDPVWSSFQNVYQLLYSIHTEGSKPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU15</accession>
    <name>A0A8B7ZU15_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110988783</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108295.1">
        <property type="nucleotide sequence ID" value="XM_022252603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZU15"/>
    <dbReference type="GeneID" id="110988783"/>
    <dbReference type="KEGG" id="aplc:110988783"/>
    <dbReference type="OMA" id="GPYLIVH"/>
    <dbReference type="OrthoDB" id="425619at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054465">
        <property type="entry name" value="Integrase_p58-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22938">
        <property type="entry name" value="Integrase_p58_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108295.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="37191" checksum="A0D294DD0D532F99" modified="2022-01-19" version="1">MCRLLGIEKTRTTPYNPKNDGMIERFNRTLVAMVSMMLEPHRRQRDWDEKIPLAMFAYRASPQESTGESPNMLMLGREVLLPVDLTIEQHSDGQPDEDGIGTDYAQQLREQLSLAHDRARKCLKQSARRQKNYYDRRSATDKLVVGEFAWLHNPAKKKGVSPKLQCRWEGPYLIVHQLSEVIFRIQRKKRGKMKVVHRDRLKPYTGEPLVAWIEDGSEETSTSTLSQRQPENRSPARTQVSGSYSNGQSETPIRRGRPLNPNASPFTIAASPQPAHAADTPNQHNPFPGIPTRRDDTEGPEVPSAPTALRRNPPGIDECHRDTFKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUD4</accession>
    <name>A0A8B7ZUD4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">28S ribosomal protein S34, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110988830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108405.1">
        <property type="nucleotide sequence ID" value="XM_022252713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUD4"/>
    <dbReference type="GeneID" id="110988830"/>
    <dbReference type="KEGG" id="aplc:110988830"/>
    <dbReference type="OMA" id="HMEQQFK"/>
    <dbReference type="OrthoDB" id="16434at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032053">
        <property type="entry name" value="Ribosomal_mS34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S34, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28589:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16053">
        <property type="entry name" value="MRP-S34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022108405.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="20843" checksum="F9325E1DD6B1D9BD" modified="2022-01-19" version="1">MERVHRHVWFTGKNLINILTELPNYGIGRLVTRRRWTMLFPENEPCYLKVTRVKIDCTRPELDQGQVWGELTYRGYKREDLEIQVGAWWKKEWELIRKADEEEFCKFTPKPEHFHVAPSHARMPPLLEAMVLKQRADKGIRVDPDDLPLLDLEIRKTYRHRAYQLASQELIGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUJ9</accession>
    <name>A0A8B7ZUJ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 345-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110988186</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107181.1">
        <property type="nucleotide sequence ID" value="XM_022251489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUJ9"/>
    <dbReference type="GeneID" id="110988186"/>
    <dbReference type="KEGG" id="aplc:110988186"/>
    <dbReference type="OMA" id="HNQDNPN"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000621">
        <property type="entry name" value="FLT3-interacting zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000325">
        <property type="entry name" value="ZFP90 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000005">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001009">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000003">
        <property type="entry name" value="Zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000202">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000290">
        <property type="entry name" value="Zinc finger protein 697 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000110">
        <property type="entry name" value="Zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001182">
        <property type="entry name" value="Zinc finger, C2H2 type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF247">
        <property type="entry name" value="ZINC FINGER PROTEIN 977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="511"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="623"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="679"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022107181.1"/>
        </source>
    </evidence>
    <sequence length="722" mass="80503" checksum="24415E9B4232218E" modified="2022-01-19" version="1">MTTAKRQGEQLSDFGVCEKDRSPEVKAHSDLLSKSGLTMSGDEQASSSIPTAGGDPHRHRRKRNRPVQYRPTDSFDVQPSIATGGFTHGLSTPPSNFQHHCITLPSEITSTIRQAKKPGSGVNDQGCEGTVPSVDDPDPAKPVNLMGIMDIHKTIARQLEQASSFANSEHQPCPFCSYVFSSVAFLARHLKYRHGINLEMQVDLPPDTTEPSGQTPYQPTPNADQDPSLNLVSASASLNCSNRGQRNTEELLQPSLMNGDGNIESWSNLSIHTPEVSKSEVKGQRSEISNKLLDRLGPPMFRQVAVDSQPGQPIIVCDKCTRAFTTKEDLEQHQQVHNVAKAYQCQHCHKLFQNPSSLKKHTRLHTDGKIYACEYCDKSFAAAAYLKTHLRLHTKQKPFVCRHCGKAFAASGTLISHERIHINDKPYGCEFCGKRFRQGSHLNRHKIIHTNLKPHVCSKCSRAFADVANLRRHERIHNQDNPNVCAECGKSFINLSSLKKHERLHTNEKPYVCRHCSKPFASSGNLISHERTHTNERPYVCKECGKAFTQSSHLKAHMGTHSMDTLYVCKHCGRGFTQRSTLCVHERIHLNKKPYTCKICDRAFTQSSTLKAHIRTHTKEKAHICKVCGKAFSARGNLRTHELIHTDEKPFKCEMCTKAFKQGSTLRAHERTHTNERPYVCRACGKTFADGSNLKAHILRIHSGGNSPGLGLVPGGLLGTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVQ5</accession>
    <name>A0A8B7ZVQ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Cardioacceleratory peptide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14" type="primary">LOC110989505</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109631.1">
        <property type="nucleotide sequence ID" value="XM_022253939.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109632.1">
        <property type="nucleotide sequence ID" value="XM_022253940.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109633.1">
        <property type="nucleotide sequence ID" value="XM_022253941.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109634.1">
        <property type="nucleotide sequence ID" value="XM_022253942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVQ5"/>
    <dbReference type="GeneID" id="110989505"/>
    <dbReference type="KEGG" id="aplc:110989505"/>
    <dbReference type="OMA" id="PEMCESC"/>
    <dbReference type="OrthoDB" id="5987909at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241:SF83">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 150-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24241">
        <property type="entry name" value="NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="63"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022109631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022109632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022109633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022109634.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="43257" checksum="87307FFAEEA25F43" modified="2022-01-19" version="1">MTTESTDSRTQMLTSIYTVEVTDMFAFYDNDTVGEPDPNKNSWLPMEFQITALWFVFAVSVVGNLLVFQWMRFNWHRKSRVNTIVLGIASADLSVSLFAIMPTAVIESSGPWTAGNATCKIVMYIQGAALISSGNMIAIMAIDRHQAVRSPLSAFIPAWKLVLGAWAAACVLAVPQFFIWLVKERSGRLVCGTILSKDQPGLRMAYLTYVAFITFLVPFGIISVAYVRLCKTIWEKSRECSGKQRHGQIELRRVPTGTLTKAKKKTLKMTIVIIAVFVLCGSPYFIVEMLRTYRAELLSPGVYNLFSIFAVTNSALNPFVFLFFNVTTRFWKDMFPCVSKSSPEATYNRYSVKFSSSNSRQHSKSYGDPHTRATDLESGVTINCTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXF2</accession>
    <name>A0A8B7ZXF2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transaldolase</fullName>
            <ecNumber evidence="3 8">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110989775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 8"/>
    <dbReference type="RefSeq" id="XP_022110089.1">
        <property type="nucleotide sequence ID" value="XM_022254397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXF2"/>
    <dbReference type="GeneID" id="110989775"/>
    <dbReference type="KEGG" id="aplc:110989775"/>
    <dbReference type="OMA" id="FATIKKY"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110089.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="36691" checksum="14E748EDA11FF80A" modified="2022-01-19" version="1">MSSPKRQKMASLLEQLKNFSTVVADTGDFELINQYRPTDATTNPSLLLAAAKIDKYNHLIEDAINYGKKNGSVLKEQVTSTMDKLFVNFGVEILKIVPGRVSTEVDARLSYDVERQVSKAKKLIALYEDQGISKERVLIKLSSTWEGIQAARILETECGIHCNLTLLFSFAQAVACAEAGVTLISPFVGRILDWYKASTGKASYEPAEDPGVLSVKKIYNYYKKFGYKTVVMGASFRNIGEITELAGVDYITISPKLLEELKSTNAPLTRKLSVESAQDSAIEKLTLSEQQFRWLHNEDRMAVEKLSDGIRNFAADAIKLENMLKEKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYR0</accession>
    <name>A0A8B7ZYR0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein FAM81A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110988982</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM81 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108711.1">
        <property type="nucleotide sequence ID" value="XM_022253019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYR0"/>
    <dbReference type="GeneID" id="110988982"/>
    <dbReference type="KEGG" id="aplc:110988982"/>
    <dbReference type="OMA" id="MQKITME"/>
    <dbReference type="OrthoDB" id="10014002at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029619">
        <property type="entry name" value="FAM81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22420">
        <property type="entry name" value="PROTEIN FAM81A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22420:SF4">
        <property type="entry name" value="PROTEIN FAM81A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="181"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="279"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022108711.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43140" checksum="885786E9EEE0B9E5" modified="2022-01-19" version="1">MARYPGGGQLPPIHWDDRDSPSHPRPLAGNKQVYFGSHGSPLFDDSPHSAIVSRAVLLEQDFANNLSQGQGGSVLWQERNAQAVLQDYIHTVTMAIKKISKEMEAIEEQLRNKERATELTTNSLKNLELQHVGSISDLRQRVGRCDVSIAKLSGDSRRTSESLAAINKQVQDQSIQHGKTVSDLEIKISRLETQLAKSTSDQHSQVGSIETESKHQVTLLETKTMNRLEELQRTLDTLQMKRDSDWQLMERSLTTTVESTISKRDRKQELFEQKILNRLEDMEKKLMLQEGTIRTMSDELHALLGDKIKKLEARLQQRQEALQGEVKRDLEEMGEQNESGFKRVKDSMATMRIVLEGKQQLLAENLQKQVANVKKLVVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A095</accession>
    <name>A0A8B8A095_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Synaptotagmin-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110990411</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022111099.1">
        <property type="nucleotide sequence ID" value="XM_022255407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A095"/>
    <dbReference type="GeneID" id="110990411"/>
    <dbReference type="KEGG" id="aplc:110990411"/>
    <dbReference type="OMA" id="SIEYNFE"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903531">
        <property type="term" value="P:negative regulation of secretion by cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08388">
        <property type="entry name" value="C2A_Synaptotagmin-4-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000039">
        <property type="entry name" value="Synaptotagmin 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000051">
        <property type="entry name" value="Synaptotagmin 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF369">
        <property type="entry name" value="FI18813P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="168"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="304"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022111099.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49097" checksum="59A0237AF8609D21" modified="2022-01-19" version="1">MGLGDKTGDDSGQKYQLSTAALVGVCLAVITSVLLLVLSVYHCYRRRYKASFFHGGTVEKGNRTFYARPTSKPISSPELSSPESLHGKVMPTLGPSKSFPPGTLSPVSPLSHEKKALMKTYSTTGGGSGGMDPGTFNKDCYSEGGELKSESGWQGDNKLQSSTEDLTQLGQITFTVEYRTDKGVFTVTIHQAQGLPVKDPQSGTSDPYIKLCLLPEKKHKVKTRVMRKTLEPVYEETFTFYGLAYNQLQGVTLHFVIMSFDRFSRDDVIGEVVVPLANIDLSEKPVTLTREVKPRHPKISKSQGRGELLTSLCYQPAANKLTVVVLKAKNLPKMDVTGLSDPYVKIYLMYNNSRLAKKKTRLKKRTLNPVFNESFLFDVPLEGLENVSLEFQVLDHDRVMKNEIIGRLVIGSKAGESEAQHWTDIIRNPRKQMAEWHKLTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0P6</accession>
    <name>A0A8B8A0P6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plexin-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111254.1">
        <property type="nucleotide sequence ID" value="XM_022255562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0P6"/>
    <dbReference type="GeneID" id="110990517"/>
    <dbReference type="KEGG" id="aplc:110990517"/>
    <dbReference type="OMA" id="CANPAIE"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000868">
        <property type="entry name" value="Plexin D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSI" evidence="2">
        <location>
            <begin position="90"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PSI" evidence="2">
        <location>
            <begin position="251"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111254.1"/>
        </source>
    </evidence>
    <sequence length="403" mass="44982" checksum="A514C84515BE0143" modified="2022-01-19" version="1">MPITLAGQQMIVTLQKLPQLHDGHHYVCRFGDIFDYQATNYNKDSLACRTPPQDNLPPLPTGEDHVIVSLSVMSMETGVNFVSIDLSFYECGTHTSCVSCVGSDWACNWCVYENRCTHNDSICSKPNEIIVTGQYNRGTTMDGPDACPQLQPQNGEVLIPNNVNTEITVNVSNFPLSTMLSRYQCSLNIEGVDQFVEATRDDSTVACTRRSFTYTSIEQELNATLSIWWTDDNNNIHRVDDRHGFTVTLYKCEVLRPDCSRCVSEETTRAELGCVWCGNTCGVLASAVCETAAEIVNLHNEINCPDPVIMMIYPLFGPDEGNTIITVMASDLGRRFSDLREVTIGGQICDFHDLEMYYRTGASVHCRTRSSYDLRPQLIQASITGANGIEQRSHGEATFRYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0S3</accession>
    <name>A0A8B8A0S3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110990083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110585.1">
        <property type="nucleotide sequence ID" value="XM_022254893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0S3"/>
    <dbReference type="GeneID" id="110990083"/>
    <dbReference type="KEGG" id="aplc:110990083"/>
    <dbReference type="OMA" id="GPHNTAK"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022110585.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="16180" checksum="D69CFCF8202B77E1" modified="2022-01-19" version="1">MAPSVRPLVKRKIVKKRLKKFKRHQSDRYHRVKTNWRRPKGIDNRVRRRFKGQMKMPNIGYGSNKKTKHTLPNGFRKFLVHNVKELEILMMTNRRYAAEIAHGVSSRKRKSIVERAQQLAVKVTNAHARLRSEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1G4</accession>
    <name>A0A8B8A1G4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemocyanin AA6 chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110990726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022111514.1">
        <property type="nucleotide sequence ID" value="XM_022255822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1G4"/>
    <dbReference type="GeneID" id="110990726"/>
    <dbReference type="KEGG" id="aplc:110990726"/>
    <dbReference type="OMA" id="NINGLPY"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1520">
        <property type="entry name" value="Hemocyanin, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.10">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013788">
        <property type="entry name" value="Hemocyanin/hexamerin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000896">
        <property type="entry name" value="Hemocyanin/hexamerin_mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005203">
        <property type="entry name" value="Hemocyanin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037020">
        <property type="entry name" value="Hemocyanin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005204">
        <property type="entry name" value="Hemocyanin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036697">
        <property type="entry name" value="Hemocyanin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511">
        <property type="entry name" value="LARVAL STORAGE PROTEIN/PHENOLOXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11511:SF4">
        <property type="entry name" value="PHENOLOXIDASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03723">
        <property type="entry name" value="Hemocyanin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00372">
        <property type="entry name" value="Hemocyanin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03722">
        <property type="entry name" value="Hemocyanin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00187">
        <property type="entry name" value="HAEMOCYANIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48050">
        <property type="entry name" value="Hemocyanin, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022111514.1"/>
        </source>
    </evidence>
    <sequence length="692" mass="78540" checksum="12C1022DA03628AA" modified="2022-01-19" version="1">MASKQDSVLTLFCADEHSPAIPTGSDASVPLAGYAFLPSSATVPEVDIFPSGIGHLQKGHQFSIFKKSHAEEAATVVNYLLSLDSFQKFKEDSARLRPILNEGIYLYAVSTAVLHRKDTDGALLPPIWEVNPRSYFPGTIIKRALDLARNRRDKDDSSPPPAFITGNYRDPEFKLAWWREDCSFNSHHFHWHQSYPWTGIEGKTKDRQGELFYYMHQQMLARYDAERIAVGLTRVEPFCNWHLPIAEGYNPQLTDYYGTYQFAARPAGMILADNWRDPSDPTLIIQQEYHRNRLLDAINTGKFEKPDGSKVAVDIDGLGAAIEANVSTPNPHLYGSVGIHNRGHDILAGITDPDLRYNQAGGVMGDTAAAIRDPMFFRWHKFVDDLFFLHKIKLTPYTEAELSFEKVKVDSVKLQIGGKNMVRDRSKSVKLYFDFCVTELNCTFLKMTGPADILTTRMENVEVDIANDMFLRQGDKPNTEAKVTVKQVNHDNFNYKIGVENKRGRNMRVAVRIFMAPSSDAEGAQFLLDTQRRLFIEMDKFVTTLEKNGMNTITRSSADSSVIKPRELTIAELRKRVLQKSEVQDKDCCRPDRYCECGWPEHMLVPRGTAEGMKFDLFVMVTDWASDSSTDDLDRGTSYCGVKDKKYPDKRAMGFPFDRKIDKSLYKSVFDFARGFPNMKCVPINIKWVSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1Q5</accession>
    <name>A0A8B8A1Q5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transient receptor potential cation channel subfamily M member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111614.1">
        <property type="nucleotide sequence ID" value="XM_022255922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1Q5"/>
    <dbReference type="GeneID" id="110990827"/>
    <dbReference type="KEGG" id="aplc:110990827"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099604">
        <property type="term" value="F:ligand-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050927">
        <property type="entry name" value="TRPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041491">
        <property type="entry name" value="TRPM_SLOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800:SF12">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13800">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18139">
        <property type="entry name" value="LSDAT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRPM SLOG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111614.1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10360" checksum="B7C24592079D5377" modified="2022-01-19" version="1">MDTKNPKEVLLDPNHTHFILVDDGTVGSFGVEIKFRAKMEKEISEQKVYGNTNVSVPVVCVVVEGGPNTIFTVFEASIFLAKVIASAHELNRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1T5</accession>
    <name>A0A8B8A1T5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="20">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27 28" type="primary">LOC110990313</name>
    </gene>
    <organism evidence="26 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 20">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="20"/>
    <dbReference type="RefSeq" id="XP_022110929.1">
        <property type="nucleotide sequence ID" value="XM_022255237.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110930.1">
        <property type="nucleotide sequence ID" value="XM_022255238.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990313"/>
    <dbReference type="KEGG" id="aplc:110990313"/>
    <dbReference type="OrthoDB" id="5809444at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005899">
        <property type="term" value="C:insulin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005009">
        <property type="term" value="F:insulin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05032">
        <property type="entry name" value="PTKc_InsR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001227">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000026">
        <property type="entry name" value="Tyrosine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006211">
        <property type="entry name" value="Furin-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000494">
        <property type="entry name" value="Rcpt_L-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002011">
        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF525">
        <property type="entry name" value="INSULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00757">
        <property type="entry name" value="Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01030">
        <property type="entry name" value="Recep_L_domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00239">
        <property type="entry name" value="RECEPTOR_TYR_KIN_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 20" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 20 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665783" description="Tyrosine-protein kinase receptor" evidence="23">
        <location>
            <begin position="31"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="973"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="475"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="25">
        <location>
            <begin position="591"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="1039"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="716"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="826"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="873"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1364"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1387"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1073"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022110929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022110930.1"/>
        </source>
    </evidence>
    <sequence length="1400" mass="156317" checksum="66D4C4D0C86C7484" modified="2022-01-19" version="1">MLGVVSRAVPACCTLAAMLLVLSTVNCSKGAEEICGSMDIRNKVDNFKELENCSVIEGDLHILLIEEASPGDYDHLSFPKLREITGFFVLYRVSHLLTLRHLFPNLAVIRGDTLFYNYALVVYEMLEMQEIGLTGLVTILRGAIRLEKNPNLCYMDTIDWSLILREGTDNNFIVDNKDQGGCLNFCPKSGGRNTCRMPTALGTVRELCWSSEHCQKVCPPTCLSACNGMRCCHDSCVGGCSGPTNRDCIACRKLAYNGECINTCPAYTYEYKTHRCIHAAQCPQHWKLHNGQCIEECPTSFITNITNARYCQPCDGPCPKVCEGRMVVNSVGDAANLAGCTIINGSLEIGIRSGTNIMKELEKNLGMIEEVTEKIVIRMAHSLVSLNFLKHLKRIGGTVLENGLYSFYLLDNRNLQQLFDVQNYPNITISNGSLFFHNNPKLCVSNITTFESRANFLTQPKNNNFGTNGDQVACSMHKIRISVKPMASTLMIRWGFDVSKISDKRNLLGFIVSYRKAPFKNVTIFDGEDACGTSQWETIYENPGEPFTLLVGLEPWTQYAIFVRSYMIANTGEGAQSDIKYVSTKEKEPGPPSDLVVLANSSNQLVVSWGPPKKPNSLVVEYRVRWQKQELAVSQFSSRDFCREKPPTLVSEVIVKPEEQDTEGNQTCQEGCCPCPKDKETLKLEEEEALFQKQFENFLHNHVFIQRDYVGLNRTISRPDAKRRRKREAPEDSPAGTPPSAFTTLSPGSFRVGNSTSPSPVPGLGTSPAPTPLVFMEQFVTNTTFVLEGLDHFTEYMVEVQACNKVTCGLKMATFGRTLPKRDADAVPPSLTANVTSKDPQNRRVKLSWEEPPSPNGIIILHEIVYNKIEAQDREAPPSGSGDQTGSEKNREDVVGKEATPTPENKPKGVEICVSAARFRQQGGYEFAGLEPGNYSARVRVFSLAGEGVWTDPLMFTVPEPVRVPTAVPNSGLGAMGITIGSCVTVVIILVVAIWCLIRWRYKKNQMPDGVLYASVNPEYMSTSDMYVADEWEFPRNQLDIICELGKGSFGMVYEGRAKKILPDEDVTTVAVKSVQANASIRDRIEFLNEASVMKAIHTHHVVKLLGVVSKGQPTFVIMEYMAQGDLKNWLRARRPENQTDVPLQNRKYPPSLPEILNMGVEVADGMAYLTAHKYVHRDLSARNCLVSADNTCKVADFGLARDIYQSDYYRKEKGGMLPIRWMAPESIRDGVFTSSSDVWSFGVLMWEIATLSELPYQGMSNEEAGEYVKNGSVLNKPECCPDKLDEIMVMCWQYNEKLRPTFLEIIQLFENTGTVLPRFAQNSFYHSEERQHQQQDSHDKLDEEELERVSILGDSEKDIYENMAPKERKRIPKNGLVPANGRAVHNGSNDSSIGKVTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2A2</accession>
    <name>A0A8B8A2A2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990704</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111492.1">
        <property type="nucleotide sequence ID" value="XM_022255800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2A2"/>
    <dbReference type="GeneID" id="110990704"/>
    <dbReference type="KEGG" id="aplc:110990704"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111492.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="16196" checksum="8E7DC630C2A0F5A9" modified="2022-01-19" version="1">MYMYKEGKNYSSSSVGVDWKGNRESAPGVLHLIRWTILLRLLSLDGASGWDGKMGTNAHEILLDCEPVIGEDQVSSLQMVVETTLPSYMYISSAFSRRGEFNLSQSKRTFEKNGCKRSSFFDLKVYSLRMPGYVSLRYRWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2G7</accession>
    <name>A0A8B8A2G7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Syntaxin-17-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8 9 10 11 12" type="primary">LOC110991069</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111877.1">
        <property type="nucleotide sequence ID" value="XM_022256185.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111878.1">
        <property type="nucleotide sequence ID" value="XM_022256186.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111879.1">
        <property type="nucleotide sequence ID" value="XM_022256187.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111880.1">
        <property type="nucleotide sequence ID" value="XM_022256188.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111881.1">
        <property type="nucleotide sequence ID" value="XM_022256189.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111882.1">
        <property type="nucleotide sequence ID" value="XM_022256190.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111883.1">
        <property type="nucleotide sequence ID" value="XM_022256191.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111884.1">
        <property type="nucleotide sequence ID" value="XM_022256192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2G7"/>
    <dbReference type="GeneID" id="110991069"/>
    <dbReference type="KEGG" id="aplc:110991069"/>
    <dbReference type="CTD" id="55014"/>
    <dbReference type="OMA" id="YPVMGAL"/>
    <dbReference type="OrthoDB" id="10035606at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059001">
        <property type="entry name" value="STX17_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF139">
        <property type="entry name" value="SYNTAXIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26585">
        <property type="entry name" value="STX17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022111877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022111878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022111879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022111880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022111881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022111882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022111883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022111884.1"/>
        </source>
    </evidence>
    <sequence length="342" mass="38053" checksum="52307800B6A8E01D" modified="2022-01-19" version="1">MAAFGDDETMTSSMYSAMQGTQPLKRFEPSVQKFTKTVVPTDLERLRQHRVNIEKFQKQKNWAKLTTEQVNARQTVQQLKANIREMEKTRSLVIESDLPSFDSRVSPIKEEAILAVMQFIEMNNLDHSPLGEVRPKDSDESDTDSGLRKRHVDSTEDFEVIAAEDEVSEDASVQADDTRERELEHLMQQQTLLQSKESMESLENLQKDLVSLNSLLHQFATHVRVQGEAVDNIADNIDKSEENVTTGRRHLIKASTIKAAVLPVGGAIIGGCLGGPVGLYAGLKVGTVAAIGGSALGFVSGRLLKKRRDKQASVELEEMDRAQQPRRRASDPGPSSMEKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A690</accession>
    <name>A0A8B8A690_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990703</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111491.1">
        <property type="nucleotide sequence ID" value="XM_022255799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A690"/>
    <dbReference type="GeneID" id="110990703"/>
    <dbReference type="KEGG" id="aplc:110990703"/>
    <dbReference type="OMA" id="HERLIWH"/>
    <dbReference type="OrthoDB" id="10062908at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009689">
        <property type="entry name" value="DUF1280"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424">
        <property type="entry name" value="PROTEIN CBG23806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31424:SF3">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06918">
        <property type="entry name" value="DUF1280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111491.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="20896" checksum="5FBE131B1F87E93D" modified="2022-01-19" version="1">MQKRQNVLLNDNLTGSLIPLVFHSDKAYGCNGVESRDVPFVHIKNLVSLVMDYLETHDRCGSLTWHNGVIPKNEVWTIIGGDKGGKSFKMSFQIVNTYHPNSLQNTVVFACFEGDDSIINLQTTLPPVLEQVSQLIGQKWRDKTLHLFIFGDYELLTKMYGICSCNARYCCLLHNIQGQHATPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGR2</accession>
    <name>A0A8B7XGR2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Twist-related protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110973443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079978.1">
        <property type="nucleotide sequence ID" value="XM_022224286.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079979.1">
        <property type="nucleotide sequence ID" value="XM_022224287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGR2"/>
    <dbReference type="GeneID" id="110973443"/>
    <dbReference type="KEGG" id="aplc:110973443"/>
    <dbReference type="OMA" id="DETDQKM"/>
    <dbReference type="OrthoDB" id="8583783at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11412">
        <property type="entry name" value="bHLH_TS_TWIST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000030">
        <property type="entry name" value="Twist transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050283">
        <property type="entry name" value="E-box_TF_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047093">
        <property type="entry name" value="TWIST1_bHLH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23349:SF50">
        <property type="entry name" value="PROTEIN TWIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="217"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="166"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022079978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022079979.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35119" checksum="C7505DA7D093C50C" modified="2022-01-19" version="1">MMEGCHQQNSRVKGHLPYWQRPMRALPLLADATQYEELHKRQFAACQLGQGYIAPSFGSLSSPGPKTTEWAGSPPPPSPVTPPRTTAAFNRAAAAPTPVPVKLTMVPGAIKMEPDDSRCSSNLNHHHHTDNQYSVVSMMNKHSTSSTDHHHECLMNGNDVLKQRYMQGRKRRHSRGTASNDDEHSDGSEEGSVNGNCSNSKVRRKGSPPQSYDDLQNQRIMANVRERQRTQSLNDAFTNLRKIIPTLPSDKLSKIQTLKLASRYIDFLYQVLRSDETDQKMIGSCSYMAHERLSYAFSVWRMEGAWNSMAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGS6</accession>
    <name>A0A8B7XGS6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ficolin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110973449</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022079984.1">
        <property type="nucleotide sequence ID" value="XM_022224292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGS6"/>
    <dbReference type="GeneID" id="110973449"/>
    <dbReference type="KEGG" id="aplc:110973449"/>
    <dbReference type="OMA" id="IRPKCRT"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF6">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034742640" evidence="7">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="8">
        <location>
            <begin position="48"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022079984.1"/>
        </source>
    </evidence>
    <sequence length="271" mass="29981" checksum="A6CA8EAEA6FA7128" modified="2022-01-19" version="1">MMKLVCLVVAILCVLETVGQQIAQKPPPAIPPPDKTCCGGIYNGAAGGAPVHMPTNCQDIRELGGGRDGVYTIFPAFSDLCRPVRVFCDQSIQGGGWTVIQRRMDGRLNFNRDWASYRDGFGYNSGELWLGNEVIHAISAQARYELLVVLEDWQFTTVESHYRNFYVGSEATNYTLRVAGFTGGPAGDALSAHNGNQFSTYDRDNDRWAGNCAVEYTGAWWYSTCHNSNLNGQYLRGIVGAGQNAKGVVWFTFHGYGYSLKTSIMMIRPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIL9</accession>
    <name>A0A8B7XIL9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110973824</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080647.1">
        <property type="nucleotide sequence ID" value="XM_022224955.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080648.1">
        <property type="nucleotide sequence ID" value="XM_022224956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIL9"/>
    <dbReference type="GeneID" id="110973824"/>
    <dbReference type="KEGG" id="aplc:110973824"/>
    <dbReference type="OMA" id="GRVRHCA"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140300">
        <property type="term" value="P:serine import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF8">
        <property type="entry name" value="SIDEROFLEXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022080647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022080648.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="35828" checksum="593D0BC8ABCD75F5" modified="2022-01-19" version="1">MTSSLTAPRLNLNEPKWDQSTYLGRAKHFFTVTNPLNVFLTNHQLDEAKKIVEAYKRGQLPNATEAQLWQAKYRYDSAFHPDTKEKMFLIGRMSAQVPMNMTITGCMLTFYRTTPAVFFWQWFNQSFNAIVNYTNRSGDSPVSNSQLGLSYALATTGAVTTAVGLNSVVKKAPVIVGRFVPFIAVAAANCINIPMMRKQELQQGIPVFDEEGNRIGESKVAARKAILQVVFSRICMAVPGMSIPPVIIHRLEQGGFLKRYPFMNAPIQVTLVGVMLVFATPMCCALFPQKSSIGSNRLEPELRATIKQSGGSIDRVYFNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIR4</accession>
    <name>A0A8B7XIR4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">TWiK family of potassium channels protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110973846</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080689.1">
        <property type="nucleotide sequence ID" value="XM_022224997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIR4"/>
    <dbReference type="GeneID" id="110973846"/>
    <dbReference type="KEGG" id="aplc:110973846"/>
    <dbReference type="OMA" id="YKEDAFF"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF330">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="16">
        <location>
            <begin position="127"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="16">
        <location>
            <begin position="279"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022080689.1"/>
        </source>
    </evidence>
    <sequence length="368" mass="40361" checksum="FFD7D0C498995F05" modified="2022-01-19" version="1">MGVVSAVKRFTRAVIPHIIVLSLLFGYLIFGAAVFSYLESGNSDVEMYNLERDELKEKLMSIKAENDYSIPSRNESSLAPGIQEASTVAVGTSIPDEDVGEVVNELIDRSLRPEWKVGRMQAVQSNRAWSFASSMLFCLTTITTIGYGDVVPVTVEGKVFCVIYSIFGIPLTMLYMGGIGSFLARLILTLCKILHLGQPIKRAMCPCGTRRKSESYEAAKSSSKRKTSQAKEVQEEKAEKDGSMAELSVVTTQHGVEAGHGVTSSVEDELEAPVLLVVAIITGYMCAGAFLMAGIEDWSYGEALYFTFITLTTIGFGDYVPMMLYKEDAFFVCMVYALFGLAVISMCIALVQAKVRRLGNRFWDCIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIW5</accession>
    <name>A0A8B7XIW5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079880.1">
        <property type="nucleotide sequence ID" value="XM_022224188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIW5"/>
    <dbReference type="GeneID" id="110973387"/>
    <dbReference type="KEGG" id="aplc:110973387"/>
    <dbReference type="OMA" id="RYKFEAW"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079880.1"/>
        </source>
    </evidence>
    <sequence length="94" mass="10855" checksum="B91FDCB498645F9E" modified="2022-01-19" version="1">MADRRIGSDAFEVAAEEIKRLNKVPDNQELLDTYKYYKQVIIGDCNTARPGILDQKGRAKWDAWNGIKGMAKEEADKLYVEYVNKLKEKYGLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJ61</accession>
    <name>A0A8B7XJ61_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histamine N-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110973439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079975.1">
        <property type="nucleotide sequence ID" value="XM_022224283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJ61"/>
    <dbReference type="GeneID" id="110973439"/>
    <dbReference type="KEGG" id="aplc:110973439"/>
    <dbReference type="OrthoDB" id="5984880at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022079975.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13769" checksum="18ACB6BC4BF89CCD" modified="2022-01-19" version="1">MTTLTDSCGVLRLWNHFPRFQDNLLKLISTTHLLEYLDGRGIAYTEHCQPSRVDVTECFDETSEKGGRVLDALLHILRFRETASFELQAEVMNCLASCSEKSGSRVFLTNDWDAVVASKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJ81</accession>
    <name>A0A8B7XJ81_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110973933</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022080858.1">
        <property type="nucleotide sequence ID" value="XM_022225166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJ81"/>
    <dbReference type="GeneID" id="110973933"/>
    <dbReference type="KEGG" id="aplc:110973933"/>
    <dbReference type="OMA" id="ANSPWFA"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034263915" description="Multiple inositol polyphosphate phosphatase 1" evidence="14">
        <location>
            <begin position="23"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022080858.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="58011" checksum="5DB8BF8215FF90E9" modified="2022-01-19" version="1">MDVLQVELSIFRLIFFPLLTLCGPVGNTVPLYATKTGYDLSLETTDSIRNSQLHWLQLAESTGASVPEGLDNCTPYGVYTVYRHGTRYPSDGDLEDVHNIIERLRSTDVNPEFQYLRNVTEVPISNASMLADSGWSEMRELAGRLKNRFPELFPDSDVDLGRYSFQSTGKTRTIDSARGYIEGVVGDDQTCQTNYSERAFTVRCTENAGSPTPTSTTVPHNPIDNDPLLRFYDIWEECTEAVNGGRTKREQNEFRDGPEIGEVWLRVAQELAGPGEGTWDISREEVILLSEMCGYDRALYNDTETWCKLFELEDLYAPEYHSELKNYWNKAYGFSINYRISCTLAQDALNYLQDRVNSPLQSPLGNFKFAHSETIVPLVALLGLFDDPLPLVASNFRENINRTFRAAHMSPFAGNVAFALYGCTSDSAVTFRVQTLLNESPVQLDFCNGQFCSLEEFRTGLERAIGTCNFTEECAEVLLEVTTQQPDSGADITYSVCLNFLLAYVALIALSFTRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJG7</accession>
    <name>A0A8B7XJG7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080090.1">
        <property type="nucleotide sequence ID" value="XM_022224398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJG7"/>
    <dbReference type="GeneID" id="110973519"/>
    <dbReference type="KEGG" id="aplc:110973519"/>
    <dbReference type="OrthoDB" id="5970923at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011049">
        <property type="entry name" value="Serralysin-like_metalloprot_C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101967">
        <property type="entry name" value="Adhesin YadA, collagen-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080090.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="63712" checksum="F57FB64DA97A0EF4" modified="2022-01-19" version="1">MSNERPHSSSRPAEAVNPLPMGAHSPIPNDPEPYAGDRLQYCYVNIEAVLKADSNIFSSSMVTTNTDACYPVICQPYTHGFILQQFQACPGLMRKINGSSKVAMPFQAILSKPVNVPPSRERCQLRVEKSFLKTQGTEGQTVTSNTSDIHQKISNVAAQGGRLICIEITGFEKSPGILQQALTGFQASKGVDLFFHMPLDPNPTRYVYQAVSIPIKFKMKYPSFSTEVEYEMETDFMGHFAGFLQRGWKLVEINYDNSIKERSSFLSSTIHANHNSIWFLEKEASKVSSDVPEWEGTIIEYEHKVKFGVFDYSVKQKTDWIPLLNEMGHRGWELACMVESPETYEVSYTVSAIKVVMFFQRRIIRPVGAWSSDVPPQSGENPPEENEPPHKAKHPSPMGSGLPFQGSNRIPQKTNPMPHGRSPMPQGSDSVLQGSNPITQGSNPVPQGRNPVPQGTNPVPQGSNPVTQGSNSPLQRSNPVPHGSNPVPQWSNPVLQGSNPVPLGSNPMPQGRNPVSQGRNLISHGPNPLPQRSNPMPQWINPLLQRSNPIPKWSNPLPQRNNPMPQWSNPVALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKF9</accession>
    <name>A0A8B7XKF9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl-CoA synthetase family member 3, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080440.1">
        <property type="nucleotide sequence ID" value="XM_022224748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKF9"/>
    <dbReference type="GeneID" id="110973722"/>
    <dbReference type="KEGG" id="aplc:110973722"/>
    <dbReference type="CTD" id="197322"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="132"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="609"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080440.1"/>
        </source>
    </evidence>
    <sequence length="699" mass="77387" checksum="57158F59B814E373" modified="2022-01-19" version="1">MQQQTTHDTFKPCLDSPAVEYPVFAVMLWYRHHHETTGHDNRYRDWIPALHVHVHVHVSMMTHLVPIVLRLISTSPSSRCYSGHAKRLVRFNSVPRLLQRAACGIPRLGKRGSSSNTVSVKPVFLNAMRQGYADRTAIVDSLGQHTYEELIGFSTALAQRILAVTPRDAPIGRRGSEVILNGERVALLCPNNVSFVISQFAAWMSGCTVVPLCKVHPLSELDYVISDSQSSVIIATREFSDKANSLAQKNDLKVLILNEDAFVTRRSKTSSQLHEHGIPQCENNVSGAVQDIVTVSNHDLIDSKLIEKQVLTQKWSQIRWKNRKAMILYTSGTTGPPKGVVTTFAALQAQISMMVEAWCWSASDVILHVLPLHHFHGLVNVLVCPLWCGATCVMMPEFDVDKVWDRLLDDCEPRVNLFMGVPTIYAKLIERFESKFIGQKARAFIKAKLKDRIRLMVAGSAALPQPVLDQWESITGHRLLERYGMTEIGMALTNPVHGVRVPGAVGNPFSTVEARIVDGEGNVCVHGTSKGSKVTPGSEAAEGELQVRGPAIFKEYWNRPDATAEAFTNDGWFRTGDTATFQAGVYRILGRTSVDIIKSGGYKISALDVERHLLAHSAIRECAVVGLPDVTWGQRVAAIVALQGGPETGLTLQELRAWAKDHMAPYTIPTELRVVDAIPRNAMGKVNKKQLLADVFELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKL8</accession>
    <name>A0A8B7XKL8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Muscarinic acetylcholine receptor DM1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110974204</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081354.1">
        <property type="nucleotide sequence ID" value="XM_022225662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKL8"/>
    <dbReference type="GeneID" id="110974204"/>
    <dbReference type="KEGG" id="aplc:110974204"/>
    <dbReference type="OMA" id="LTICAFV"/>
    <dbReference type="OrthoDB" id="10428862at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF199">
        <property type="entry name" value="IP13425P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="49"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022081354.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="45845" checksum="F6EC6C51FC92636C" modified="2022-01-19" version="1">MDNTTSVLTDDAFLNLTTIGTPIPTEPSGAGPIVVGVLLLLVVIITLAGNILTICAFVSNILLRQKPSNLLLLSLSCSDLVVGATGLPMAAIHTGLGYWPLGKAGCITLAFCSVVGVSAGMYTVTAVSLDRYFLVSREYPAYLKLQSARNVKVTIAAAWTVAVLISSCEAIVWVTGDYTSVDYTKVCLSPVRSDPRFTHVIFVLLFVIPFLVILISTLRFSFLLRKRLRKQKQARRPSFDAVNNRLAPAKGAHKVSNSATSTFLTSEFPSEMETTEFSSGLGSQQQPPLSPNQNAEPRRPLKRKPLDASWRKKSFFGMGDGSLGGSFSRAKARRRYVKPAVRLAILLGVFALCTLPYPIFIVLSKGSDCDDCILRQVRNHLSNLLLSNSGLNPFLYAVMHRRIREFYKTKLTCKRRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLS2</accession>
    <name>A0A8B7XLS2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110974050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110974050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022081061.1">
        <property type="nucleotide sequence ID" value="XM_022225369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLS2"/>
    <dbReference type="GeneID" id="110974050"/>
    <dbReference type="KEGG" id="aplc:110974050"/>
    <dbReference type="OMA" id="HTNDQLF"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051008">
        <property type="entry name" value="Telomere_Capping_Maintenance"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518:SF2">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518">
        <property type="entry name" value="MAINTENANCE OF TELOMOERE CAPPING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034528076" evidence="5">
        <location>
            <begin position="29"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022081061.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="53350" checksum="54592E2A85B199D2" modified="2022-01-19" version="1">MKLRQSLLDKAAVLVLLLTSAAEVSVQGDASCTGISKDVACKKCSESTHKCMPGEVPIDPWLVAAAKQQRELQIDEPWDRLQMLDAHNGYNARAWGFGVTDTCPWPPPYPMDCNNYANQEFSFMDLLNMGIRALEIDNWFCYNEMRMAHLGDTIDLECSETDPLFSDGIKEIADWINLPGNGEEMVRIYMNEKYNQGNDDSVNDPLEQYLGDRILTPAELADTYGGKWPTPRQMRQAGKNVVVATGSTAGSGEVYPHGGKYIHKIYWEDKQMRLFTNYPECGTKNLTNKIRYYSDATHYGNSTHLKHDGPSNGAGVIYDFTEFVKCRVQYPATDMITPDLIKTALFTWAEGQPDPELTSESCVWVSRTDWRWYVSEDCSIELYCACQSTTDPDDWKISSSPASYSSSSDACPTGYKFSVPQDGFRHQKLKDESGGNSVWINITPWLPEKESAAPSVGQLSSTALLMSLLLGSFLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM54</accession>
    <name>A0A8B7XM54_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Muscarinic acetylcholine receptor M1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110974042</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022081050.1">
        <property type="nucleotide sequence ID" value="XM_022225358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM54"/>
    <dbReference type="GeneID" id="110974042"/>
    <dbReference type="KEGG" id="aplc:110974042"/>
    <dbReference type="OMA" id="IVLYYHV"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="99"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022081050.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46123" checksum="5351F16DA45DCF59" modified="2022-01-19" version="1">MVNTTDAIYLNDHDSVGTFTDAQSVVATTRPLPHLPCTVQVVLATVVSSVVFLTITGNILVIVSFCRNKDLQGFNQCFILSLAVSDLLVGCIDMPLHFSVVSAVVISLDRFVALRKPFFHRRRWRTKRNAALLITLSYLVPIVIWLPITVLWPVFAGGRNVPTRTCKPQYVESRAVSIAAPVLFFWLPVSVVIVLYYHVYKRIRKTVAETKQRKARQKVVLSRYVKPSNGENSSATSNTKAPGNEPSNQKQPNFMLSFRESSMEGLDNVGFSDLSSSDVTERTDHQSHSSSSGCGDKNIDNLKPTNPPDNSAPTFPKTDPTKAVPDQGTSLEIKPEEVDKPNKTLSRRPQFLSRGVRSRDVERKARVENNRANRILGSIIAAMVITWLPWAIIVVVVSLCPDCLPESLYAVSFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XML5</accession>
    <name>A0A8B7XML5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110974227</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="RefSeq" id="XP_022081407.1">
        <property type="nucleotide sequence ID" value="XM_022225715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XML5"/>
    <dbReference type="GeneID" id="110974227"/>
    <dbReference type="KEGG" id="aplc:110974227"/>
    <dbReference type="CTD" id="9039"/>
    <dbReference type="OMA" id="PYLENYM"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="359"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022081407.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50037" checksum="EBEB771CE67C9755" modified="2022-01-19" version="1">MADQEESVAMETGRAEPDLFGRWNHVRKLLERSGPFAHPDFEPSPEILDFMLNSCRILVVGAGGLGCEILKDLALMGFRQIDVIDMDTVDLSNLNRQFLFRLKDVGKPKANVAADFVNQRIPGCNVTPHFKKIQDYDETFYRQFHIVINGLDSIVARRWMNSMMLSLLNYEDGVVDPSSIVPMIDGGTEAFKGNARVILPGMTACIECTLELYPPQINFPMCTIAHTPRLPEHCIEYVKILLWPQEEPFGKDVAIDGDDPTHIQWIFEKAQERADQFNIMGVTYRLTQGVVKHIIPAVASTNATIAAQCVTEAFKIASSCCGPLNNYMVFNDTDGLYTYTFEAEKKEDCVACSQVPQVLTLPEDATLQNLIDHLTESASLQMKAPGITTVVNGKNKTLYMQNPEAIRVRTKENLPKKLKELGLEEKQELIVADITAPNALIFSLSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMW9</accession>
    <name>A0A8B7XMW9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110974284</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110974284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081512.1">
        <property type="nucleotide sequence ID" value="XM_022225820.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974284"/>
    <dbReference type="KEGG" id="aplc:110974284"/>
    <dbReference type="OMA" id="ANILDCF"/>
    <dbReference type="OrthoDB" id="188352at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027876">
        <property type="entry name" value="DUF4550"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667:SF7">
        <property type="entry name" value="RIKEN CDNA 1810020O05 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33667">
        <property type="entry name" value="SI:DKEY-57N24.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15084">
        <property type="entry name" value="DUF4550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4550" evidence="2">
        <location>
            <begin position="165"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022081512.1"/>
        </source>
    </evidence>
    <sequence length="1463" mass="166336" checksum="816EAB1AD8A567F2" modified="2022-01-19" version="1">MTSVTTDEALRDTLESNVSQRAAESQEQRSRAAGQREGCQESQDNGDKNSPSLGDEESNIEKLQDDETKTSENKAAEADLEDDQINEENGENVEPSVTVEDENYAERKGSGKSKRSRKKKAKDVHKVTMTVTIAKAIPTAEEDVPKLDELMRKKKRIVEAPKAQNYYHCQYYLLPDDSEPIKTDVVTFGMAAKIYTEHDSKVLKTWQEKNQTWIAWSHSHTLKVTKELLLKLFNHTLELRIWDSKDKVSSRARFDRPKAFRLPQAKPGEDVEDVGGVRSLVMKQSESYMSLQPRKSFIDRPVPQHGPAELKGMKNFGKKDAKGRPVPPSPENTKTPGQSPPSEVIKVEKRHSEEEEEQVRESKIDMYSALPPAAEVQSDEMKSYAHLGKLAGLPPPEELKEIKKKLKKEKIVALSQQKDSDGAKRQADTAGKGRDSSQGRGGDSRTGSNSAPTPGRRGFKESPQQREARRKSHKAEHAAAALAMYIKQYGNACIPIRMKLLFAGLRSVTNRLTTPVRGLEDVFLTLSLDGPLMSEGLRRELNPLILKVNSGTSLPASPLPYRELARRCQPVYCAYQLFREPAYESCRKPHAKNIYWEDINVQLLGTIPKGELVEYLQGPPLEIEVHDRDRRPEEIKQKPTLFGEDIEDDKISNVGMVTAKRTLHNPFVNHLKPWDPYGLAKFDLSSLLLGERVLNLTAPIHSCPIPDVIGRNKADNRLIGYSSSADGPKDEPLPMGHYLENHSQLKIRVEVAYPLTTSQEVKLKAEIETPPECPFARIVYIFEYKDAAFLHRLLKLVTKINATALNLDKMPEHIIEAALSTYKLSEAQQESRLLDIVTGFQVMDGEKHIFVLEGLREKAINLIWETLPRPKAKENVTFQALYNSNMMFSERRYASLDVDLCRIRLHEPLSSIVQQPLLYVRDMVPRLCLDAITKLDMLVRQDILRNAARNDLFPSAEMIVSLSKEFGVPLTTVDFEELLESQRQDKEVDIWRAQTAPIQHRHREWTPLDLYNDRYLDLLEEKKLHREPSDHIKNNIDAVRKVSERNKSKKAKPATIRAEPVNGVAHNYSTQTLNSTEQAKELLRQELAKEPNHRFTYCPEYNSATVVPVNIEAIQKQEQQDSVDAWQTKDGFIYPGMQAALEDNAHPKQPDMARRDQLTQPWTENTLHANILKPTLDEREGYSWSDRKKDMDLWKCPQKSFQPVPPITIHLAGDTLDAEQRAAWDWDQDNWRSKIAVEDTTMKFHRCATDTELYYRGPRSSNQVARLKGLLKDEPKKLALRQAGISEIPALAVVNDPSLDTAAREAGVPIVPAVDPREVERHCGFMPGPQDGKGWHMESNRIPIRDMEHAKFSELKKYDFKLYHKDRGGLHKRFIQPLTQEDRNNHLFHTVAAATTADAAHEATAAAGQKLHPGNECFRQPSPSIKAKPLRTEFYYPDREQFWSTPCPRDVTNRRMMMQTDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN63</accession>
    <name>A0A8B7XN63_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alpha-soluble NSF attachment protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110974238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081425.1">
        <property type="nucleotide sequence ID" value="XM_022225733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN63"/>
    <dbReference type="GeneID" id="110974238"/>
    <dbReference type="KEGG" id="aplc:110974238"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000028">
        <property type="entry name" value="beta-soluble NSF attachment protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022081425.1"/>
        </source>
    </evidence>
    <sequence length="292" mass="33028" checksum="29B0CE3887D429CE" modified="2022-01-19" version="1">MADNEAKGKALIDEANRKLKSASGFFGGFFGGTQKQEDACELYSRAANMFKMAKKWNEAGNSFCKCAEIRLRLESRHEAATSYVDAGNCYKKNNPQEAVKVLQRAIEIYIDMGRFTIAAKHHISIAEIYENELIDLEKAVENYERAAEYYKGEDSNSSANKCLLKVAMYAAQLEQYAKATEIYEEVAKTAMESSLLKYSAKEYFFKAALCHMCVDALNAQHAVTKYNEMFPAFADSREHKLLSKLLDAVEEQNVDNYTEAVKGYDSISRLDQWLTTILLRIKKTISGDPDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XP87</accession>
    <name>A0A8B7XP87_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Rho-related protein racA-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC110974548</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081974.1">
        <property type="nucleotide sequence ID" value="XM_022226282.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081976.1">
        <property type="nucleotide sequence ID" value="XM_022226284.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081977.1">
        <property type="nucleotide sequence ID" value="XM_022226285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XP87"/>
    <dbReference type="GeneID" id="110974548"/>
    <dbReference type="KEGG" id="aplc:110974548"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18499">
        <property type="entry name" value="BACK_RHOBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18299">
        <property type="entry name" value="BTB1_POZ_RhoBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18300">
        <property type="entry name" value="BTB2_POZ_RhoBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000202">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="333"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="503"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022081974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022081976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022081977.1"/>
        </source>
    </evidence>
    <sequence length="684" mass="77687" checksum="5BCB8C65BF65530D" modified="2022-01-19" version="1">MVDEEKVKIVLVGNDHVGKTCLCLAYCKDYFPYVYIPIVFEDYVQDVVVAGKAFAARPVDTSTLGEDYDHLRPLKYPGTDVFLMCFSVERRSSFEHIESRWLPEIRQYMPTTPIILVATKIDLRGSPQHSCVTFDEGFELAQKHNWTYIETSAVLHTSRKECHEKYVARWGEPPTLTYEKVDVFHLYFSVQSRTSLANVETRWVPEIRHAMPDIPILLVATNIDPPWSPHRTRVVTYEEGLKMAQKLNLEYTEMTGQLNLNLNECFEKAVYIADEGRTPKKKKGFFGFRRRKPKPSPPSEPEVPPVDEAPRIEIQTSTIADNFGKALEQPAFSDVVFIVGGKSILAHKVVLCSASNFFCHVFGLDLPQHKASNSPVLNFTWENINKGKITGLAGILDEVTPDGSLLEKAKTQVTISADISYKTFYHVLEFLYTGLPSLTDETSTEDLVALQKASNTFSLPMLDSIAKNLQNDGKFLNPSIGTYLNDQTGQRAKWLFLNKQTLSDIRFKVEDTLVYAHKVMLTCRCGFMNGMFTGDFTESSQDEIRIEDVSLECFLALLEYLYTDHAPIEEGDAVGILVAADRYGQDRLRNLCELYITKGVDVTEEHVDVIGLLHTAQMCNASQLAQWCLDLISRNFVAFQQRAEFKKLEGENLKYVTENRWPPVSYLEELEKYKAQCGEKGDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSK7</accession>
    <name>A0A8B7XSK7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Cholesterol 24-hydroxylase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC110975135</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082968.1">
        <property type="nucleotide sequence ID" value="XM_022227276.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082969.1">
        <property type="nucleotide sequence ID" value="XM_022227277.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082970.1">
        <property type="nucleotide sequence ID" value="XM_022227278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSK7"/>
    <dbReference type="GeneID" id="110975135"/>
    <dbReference type="KEGG" id="aplc:110975135"/>
    <dbReference type="OMA" id="NMILLET"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033781">
        <property type="term" value="F:cholesterol 24-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006707">
        <property type="term" value="P:cholesterol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20613">
        <property type="entry name" value="CYP46A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039983">
        <property type="entry name" value="CYP46A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293:SF0">
        <property type="entry name" value="CYP46A1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24293">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 46 SUBFAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022082968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022082969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022082970.1"/>
        </source>
    </evidence>
    <sequence length="517" mass="58608" checksum="601FE21AB788DE0D" modified="2022-01-19" version="1">MAFLQILGTLLISVVLFLLTAFGSLFLTYTLYLHYVHVKHSHIPGPKRTSFYWGNLAELSVAIKRNQLIDDLLFEWSKQYGRVFVFYITHKVFVQVNIPEAIKDILLVDNFPKPRRGYRFLEQLFGQPFMGKSLVTETDHETWKPMSAMFSPTFHRNFLKTCIVQFNTSCDLLLESLSKKADGKTEVNMLEMFNRVSLDCISKVAFGLHLNMFEEEKPQLLEDIRCAAESALISFLNPLLWCSPFRSASDFRKKARQAGKHLREVARECIMGSLEDLRSGKTLDNNILSHILQTSAPGNGGSATEADLEKMVDHFVTFIAAGQETTACLMASALLELGRHPEVTYKMKIEADAVIGDSGYVAFEDLSNLKYTTAVLKETLRVHPPVSSFPRQLTKDVIWDGIKVPASTNVGVNIMNLARLEEHFENPKEFIPSRFLTNESYKYVHIPFSLGPRKCIGQQFAMIEARVIMAKLMKYFHFDLVPGQSFHYVKMVTCKPKDGCLMYIRPVTGVNPVSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTZ7</accession>
    <name>A0A8B7XTZ7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110975480</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083707.1">
        <property type="nucleotide sequence ID" value="XM_022228015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTZ7"/>
    <dbReference type="GeneID" id="110975480"/>
    <dbReference type="KEGG" id="aplc:110975480"/>
    <dbReference type="OMA" id="HEEAYIE"/>
    <dbReference type="OrthoDB" id="8182187at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034375077" evidence="1">
        <location>
            <begin position="31"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083707.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="29067" checksum="CC03482738B5D1CE" modified="2022-01-19" version="1">MTSLFTCWPRHGHVTWLILSIICVIRRSDTIDDTSVMRSDFKSELHSDGTIKFRVILSNGQGSHVRCAAACLKEEYCRYFSYTRDTGQCELSDASVVSSKENRLKYFSRSVCITAYRTSGFLNYIFPLPAFDGEIVLDFALQTSADAIVSLSTDGTFGGVKYELVIGHGGGVNTVMRRCWSCTNLKVVPSEDVVNESQMRRFWLQFDNNRVALGKYHEEAYIEWTDTGNIPTPTASPVWFLGLGGWASPVDWLIYQNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXC2</accession>
    <name>A0A8B7XXC2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110976514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022085529.1">
        <property type="nucleotide sequence ID" value="XM_022229837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXC2"/>
    <dbReference type="GeneID" id="110976514"/>
    <dbReference type="KEGG" id="aplc:110976514"/>
    <dbReference type="OMA" id="ENCIAPT"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000128">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034907022" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="24"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022085529.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="65089" checksum="9DAF0496738A9568" modified="2022-01-19" version="1">MEYLKFVCVLCLVFPVVLADGEDPPVVTTSQGRIVGTRFEFSPIDPALRRSVDAYLGIPYAEAPIGPLRFKPPVAKSWSGELQATKLGNRCPQPIVPLGNYTMTGPFGEDCLCVDVFVPQPLPPDAAVLVFIHGGGYIIGAGITEDMYPTPVAAVGDVIVVALNYRLGSFGFLSTNDDVIPGNMGLLDQRLALEWVRDNIKAFGGDPTRVAIFGESAGAGSIGLHMVSPGSGGLYQGAILESGDASAPWATLPGDTARRHAFALGKLVGCERQTSEELLECLQQVEGFDKIIENQYEKLLQEFGQKSLMPFAPVIDGEVIPADPNDLYEQGAINDAVSIIGALADEGMLMVGPAFPNNTEEAPFVDSDTYDAYAKFHLSWMVTPESVVADTVKMMYADPSCAGTPDCNYLQSLSQAIGDAMFVCSGVKTAKAFTKAGRKVYHYHMSHIATTTFLGNKWTKATHGDDLLFVFGLPLVPSANWSFTEDEARMSIQTIKYWANLAKTGNPNLSSLNAEQGKEENLPEWPLFTLEELVYKDLSPSMGNGRGIKAKECLMWNEFIPKLVQTAEEAKKCRETEEAKENKDGVDEEGTCTKETCPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYI6</accession>
    <name>A0A8B7XYI6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamine-dependent asparagine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110976124</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022084841.1">
        <property type="nucleotide sequence ID" value="XM_022229149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYI6"/>
    <dbReference type="GeneID" id="110976124"/>
    <dbReference type="KEGG" id="aplc:110976124"/>
    <dbReference type="OMA" id="QFASKHT"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="UniPathway" id="UPA00134">
        <property type="reaction ID" value="UER00195"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070981">
        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000090">
        <property type="entry name" value="asparagine synthetase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000039">
        <property type="entry name" value="Asparagine synthetase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF23">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="7 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="17">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="546"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="15">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022084841.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="66051" checksum="A81F8A9BCD66B661" modified="2022-01-19" version="1">MCGIWAVFGSDGNVSELYHNAWKIAHRGPDSSRMENIIHFKSCCLAFHRLAIMDDVFGEQPMRVRAYPHIWLLYNGEIYNFRLLQKQFDFQYLTECDGEAIIHLYAQGGAEYAASMLDGVFAFCLLDTAAKKVFLGRDTHGVRPMFKLCREDSFLAICSEAKGILELEQADNNHKEETVPFLPGYVESYDLAPSGKVTLRQFTQFHSIERKPKWSDIPLAIQPHGEDMYANIRILFTDAVKKRLVSHRPLGCLLSGGLDSSLVAALVVKLAREADIQYPLQTYTIGVDGSSDTRAARQVAKHIGSEHHEVPFCPDEGTAILEDVIYSLESYDVNTVRPAVCMYLISRYIREQTDRVVIFSGEGSDELTQGYLYFHQQPSAKEGDEEGRRLLKDLYLYDVLRADRMTAAHGLELRVPFLDHHFTSYYLSLPAEARCPKLGIEKYLLRKAFDGTGLLPPKILWRQKEGFGEGVSSRKKSWLDSLTEFANEKVNPSSVDDTEFRCAEELFPFNPPKTKEAFYYRQIFEKRFPGHARWIPYAWLPKWDEDTSAPSGRVQTIRQGTGFTKAGRKSLEEGSSPGVAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2H6</accession>
    <name>A0A8B7Y2H6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM160B1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110977044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086505.1">
        <property type="nucleotide sequence ID" value="XM_022230813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2H6"/>
    <dbReference type="GeneID" id="110977044"/>
    <dbReference type="KEGG" id="aplc:110977044"/>
    <dbReference type="OMA" id="VQTEFFF"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045668">
        <property type="entry name" value="FHIP_KELAA_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF12">
        <property type="entry name" value="FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19311">
        <property type="entry name" value="KELAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="642"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="459"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086505.1"/>
        </source>
    </evidence>
    <sequence length="786" mass="87116" checksum="96D8C5D98AC56F7A" modified="2022-01-19" version="1">MFNRFTAALHHAVEVLGESDLLAPTQTLLEDFTFHWKAVTHYFINTKDDKQPVQESNIPSHLNNMLALLTQEERQMEEDQTGPCMEYLLQHKILETLHTLGKADCPPGMKQVVLTFFLNLLGKVKQPLLPHVNVYKPVHNLIKVCGEVRAGPTEKEEIQFLCTVCSKLKEHPYSVNFFLELPRQKSKKPRHNSSPSVASSSGSSSSRTSLDVTQPEFSLVNSLIALAQSPDSRIAVKACEGLMLCASLPEKHAAQCIVDHTQFCALLAERLCTLYNALPLSMDPVDVDSVEAKWGLYMQSDAEDTNMFPGKRQLISLLSWYDYCDQVIKEAHPTVGRSLANQIRERFLVPIMEQLLLQSSEVGILTSTAHLVKFVKMTTSPALLDALVKFILGEETEPEKPGEGGYKLRQRLIDRCDNISDEICIMALKLFETLFCKANGHIVTNLVLRNLQSRAYNSRTDSTENCEQGSGDTSDQGSSTTNPSDQGSSDSCDQGCGDAAGPGSSGHPSDQGSINGAVSDSGVETLSNGPESPTLIPSSPMRDGVVNSLSDAGSEATQPSPSMSTTSSETDDKTSIHKIVNSFLGLMPEEARSSYLTGDIGYDTYLREAHRLFRECSVNCLPYDWPNYPTPLERCPDEAFYEGAFLKILFDKLSRMLDQTYEVNLQVTSLLSKICLFPHPHIQEFFLDPYLPVAAGCRTMHSVLLRVVSDLSVRLRSIPDFQRQAFVVRKQLMGMVEEDDRGKKSIAPIMNLPYIDLLEGVIVLEEFCKELAAIAFVKFHAASGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3A3</accession>
    <name>A0A8B7Y3A3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cyclic nucleotide-gated channel rod photoreceptor subunit alpha-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110977671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087664.1">
        <property type="nucleotide sequence ID" value="XM_022231972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3A3"/>
    <dbReference type="GeneID" id="110977671"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000002">
        <property type="entry name" value="Cyclic nucleotide gated channel alpha 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.630:FF:000001">
        <property type="entry name" value="Cyclic nucleotide-gated channel alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF13">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="434"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="553"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="844"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022087664.1"/>
        </source>
    </evidence>
    <sequence length="871" mass="98600" checksum="8ADB429FE4E8BB85" modified="2022-01-19" version="1">MAKSALVTTVWAYTRRRHRSSIHHPSDLNIGGNMASREPDRRVNFAAERVGSIDQGPGDSNEEDIRPTDETRYQSWKRRIREYFERRFADADFVIDPEGDKIYVWMGLVTFAVLYNVWMIILRIAFKEMREDIVNRRVFGTVDFASDIIFSLDILVNFRIAFLDQGLLVKDPRRLSSHYRKSIRFKLDILAMIPLGTMALLLGELADKDVFNVQFDVDSDNILIPVLRLPRLLKWHTMESFTAMSDTRTSNPNRVRAFKLIMYLGVIIHWIGCFYYMLSEVEGFGSNEWVYPADEATQGLLSKYIRTIYWSTVTLTTIGGTASPVSNVEYVFTGITFLVGVFLFAAVVGNVGDVISNMNAARQEFTTKMDAIKFYMNHRKVPDVLQTRVKKWSDYAWSRTQALDDQTFLEILPPRLRAEIAIHVHLETLKKVKIFEDCEQGLLCELVLKLRSQIFSPGDYICRRGEIGREMYIINHGKVQVVVQDAETQQSMVVATLSEGNYFGEISLLKLDEGQNRRTADVVSLGYSELLCLSKKDLMQALVEYPDAKKVLEKHGRDRMEKNREAARMQRRKSEATLQVPGQDQLQKSPDDKAGGNNSEPAEGNGRPETGGPAGEIGLRAQIELISKLAMKGKEMSELRHIINELRNFDSMSTKAKIHELSHKCDELWKKLRQKDLDLKRALRRISELESRVTTGINGVGRAPRRFGQALVKRSKSLHLSTYDYSSVDDHESSLWASSLDSADGSANGYTPTNGMSNGHGPRGNLADKHRTPSTTDRSPEHSPRRDKYMKEMIVPGIQVNGMVKQEPLTMKWEVFADEEQSDQANDSEIEKTMSQLQPAIASLTLPSSGRGSGAISDVSCYSDASLDSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3I7</accession>
    <name>A0A8B7Y3I7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase TRIM33-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110977358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087097.1">
        <property type="nucleotide sequence ID" value="XM_022231405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3I7"/>
    <dbReference type="GeneID" id="110977358"/>
    <dbReference type="KEGG" id="aplc:110977358"/>
    <dbReference type="OMA" id="SICHARY"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022087097.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="69473" checksum="A15D82FC37C7BEBF" modified="2022-01-19" version="1">MAAGMTVESVLGSIIQGHLECSICHTRYQEPKMLLCSHSFCLRCLQELKQTQSPNTNKLICPLCQRDTTLPKGGMMKLSTNYALVALMADVTKQEQLLQNEEAQVMCQACEEDKEAISRCMDCENYLCQECEKAHQRWAALRTHKLTSLADLNKDSSIQPVSTKSYISKCDSHPSQELCFYCNTCEQLICKVCSTSSHKEPVHSFVNFKTAIDICLYGARELVSNVVKYNSTNAAIQIPTNWESSRNRLSIMLARTKQQISQKAEMEVAQIRQKETQLLQQAHVAFRRKDKKLAEMIFAEHTMGRVQSDMTETNRLDILKLRQKLLHDYKDVIKELSDDLSPELSFISFAENQTEIELGNLLLKEKWTVMSNTNITGELIASLSTNDTVVVNEGQQKLTKLSPDCKILHICPISQLQGEDPSAVKLSVNFEVNKDNQFIILFESDVKIFNKEYQLLHQFSPGKEADIEGTPTCLAVDDNNLIAVGYKDKEFISLHNSDGSFIRTLPAPAIESYMTISNRCIIYTNASTKQLTSVDYEGNKRFVVQTYQGQVPHGVCCDRAGDIYIITSSNQVKHFSAEGKYIEILVSDLDSHLDVKFTPGGQLAMTGQSTRIYRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3Z7</accession>
    <name>A0A8B7Y3Z7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110977091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
            <location evidence="5">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086596.1">
        <property type="nucleotide sequence ID" value="XM_022230904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3Z7"/>
    <dbReference type="GeneID" id="110977091"/>
    <dbReference type="KEGG" id="aplc:110977091"/>
    <dbReference type="CTD" id="738"/>
    <dbReference type="OMA" id="DIICERG"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007041">
        <property type="term" value="P:lysosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022086596.1"/>
        </source>
    </evidence>
    <sequence length="802" mass="91741" checksum="09AADA53F15D7D13" modified="2022-01-19" version="1">MATTKEDMDGEQRRRRKHGMLKMYYGLDDETGKEATTDPIDIDGAHFDPDVYLARLMREKRLTELVDREVDMVKQIRSLDSDMQTLVYENYNKFISATDTIRKMKTDFRKMEEEMDRLATNMDAITDFSAKISGTLQDRREQITKLSSVHMLLKKLQFLFELPARLKKCIEMKAYSQAVRYYVKARAVLLQYQHMTSFHGIQQDCNEIVNELRAILREQFTNKESSAKQLAESVDLLLQLKEPPDELCDEFLSHAKEKLDEDLAEIASQVDPAQVGAQQPESSAEVEGTEETRPAEKLLRSIPMDVLEFIDSSCNSFLSNISLLIASYKELFVDRQASDSQEQEKLVEVAHAKLAEFVNSHMQQYFAHVDERIKTEKSTVENSLLVRALDRFYRRLLATDRLVPQLKIIERASAIIAQCGHERALFYFDGLKRHFSECMTDIRQTLCAPRIAGKKDKPDMVDLLNTTSTSVVEQLKAILTNLKAFIASDITFSQTPYFRSLFCQDDIREGLLVAFFRHMCAASRDLCDGVGEKGSSTAPALVLVLSRLLLDFESTTISQLLVLCDELFPVDNRRGLTQTSVLCAEAQSAAQTLLNHYVKVQGLQISQMLRKSVETRDWLNTIEPRTVRAVMKRVVEDVTTIDSQVGALYEEGVRKAHSSDSSRRALSYSVSRQQQQQQRMQRSYASSSNFDTSLMSNIQKLFSERIEIFSSVEFSKVSILTGIVKISLKTFLECVRLRTFGRYGLQQIQVDTHYLNLYLWRFVSDEKLVHFLLDEVVGSALHRCLDPILMEPSIVEVICDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4V4</accession>
    <name>A0A8B7Y4V4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ER membrane protein complex subunit 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110977243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086881.1">
        <property type="nucleotide sequence ID" value="XM_022231189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4V4"/>
    <dbReference type="GeneID" id="110977243"/>
    <dbReference type="KEGG" id="aplc:110977243"/>
    <dbReference type="CTD" id="56851"/>
    <dbReference type="OMA" id="EMENMQM"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034751445" evidence="9">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="10">
        <location>
            <begin position="43"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022086881.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25228" checksum="419279C6E3669256" modified="2022-01-19" version="1">MLRTLILVLTMWACPCFMEETEDNKVNDTFTIEGKVLVTGVKAAEWLPHTRILVDGGQYVGFLRADGAFKVTGVPSGSYVVEVANPTYVFEPARVDITAKGKMRARKVNHIQSNAVVTLPYPLRFKSKQHAMYFQKREEFRITDMLKNPMVLMMILPLIFIVVLPKLINTQDPEIQKEMQNMNLMNPKTEMPDLSEMMAKMFGGGSSQPKKKEKTAKIKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5K4</accession>
    <name>A0A8B7Y5K4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Arachidonate 5-lipoxygenase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110977737</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087827.1">
        <property type="nucleotide sequence ID" value="XM_022232135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5K4"/>
    <dbReference type="GeneID" id="110977737"/>
    <dbReference type="KEGG" id="aplc:110977737"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020834">
        <property type="entry name" value="LipOase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11771">
        <property type="entry name" value="LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00305">
        <property type="entry name" value="Lipoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00087">
        <property type="entry name" value="LIPOXYGENASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48484">
        <property type="entry name" value="Lipoxigenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00081">
        <property type="entry name" value="LIPOXYGENASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51393">
        <property type="entry name" value="LIPOXYGENASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="6">
        <location>
            <begin position="38"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoxygenase" evidence="7">
        <location>
            <begin position="158"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022087827.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="80138" checksum="D4267EBF4E0600B4" modified="2022-01-19" version="1">MSRLLCCCGNGSSNDVSDGQATAMKEASSDDNLAGAHTHYKILVKTGDRKGAGTDANIYIILHNENGVTSKKIKLDRLFHDDFERGKTDEFKAKLPADFGAVHEIELWRDEHGAFDPWYLEKIDIFETPKDAPEKGPYEFPVHRWIPAKKSVIFRQYDSLLPQHDPRKDSQRKEEMEEIREIYQFRSQAPEAGLPSQVAELPSDEKFSFDYLFDLVKRKANLLLQSKLSKTFTGKWRNLDDLKNVYHGVFPKPDGMRMWRSDIEFGLQRLIRCNPTQIRLFTEVPEKFGVTDEMVGPFLEGMTIQEAIAKKKLYYIDYEILKNLPVKQGTPVVSPIGLFFVDKNKHLMPVALQLEQQKGPDNPVFLPSDPEYTWLLAKMWFNFADASYHQSCTHLGLTHLVMESVAATMHCALSPSHPLFRLLAPHFLFLMAINSRGLALLISVDGWVDKTMNIGRDGMFELIGRAFKRWRLNVEGTIINDLKAREVDDTNALPDYHYRDDGVLIYEAMEKYVRVVVESHYETPDMITGDYELQEWGRLMATPQDNGGAGVQGIPADGKFANVEDVISTVTPIMFTCSVSHCVANFSQYDDYAFPPHYPAGMRMPPPTDKSPRSEKDILDNLPEKNVTVDVMTVTRLLSEKATNSLGDFEMQYGFCPVAVKALEQFRKDLKQIEVIIDERNRHREFPYDYCHPKEVPNAISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6F7</accession>
    <name>A0A8B7Y6F7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110978261 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110978261</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088794.1">
        <property type="nucleotide sequence ID" value="XM_022233102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6F7"/>
    <dbReference type="GeneID" id="110978261"/>
    <dbReference type="KEGG" id="aplc:110978261"/>
    <dbReference type="OMA" id="DHESKEW"/>
    <dbReference type="OrthoDB" id="6044770at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="9">
        <location>
            <begin position="379"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="8">
        <location>
            <begin position="549"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022088794.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="71788" checksum="DB9636C1C54496E6" modified="2022-01-19" version="1">MIDPPCTKLMNSVSYTLYMWIIMAGLLLGPVLGLRGKSHTIENLVTEYLRDEGQLQIEGRTIVYKATVREFAFPVVYDATATDTATGITAITSESESFDDPQDAYHKAVANLLAILRQRGLMKNMNSKNKQESVETSEPKTEQPGQRQKDQEKPANDKTPGGGSNGERETKSPVPDPGITGSRKDEANSEMNLTSEEGSVSQPEEKSDEVQSGKSDEHSERETETGTVDEEGHLNGTGSARDLLQTIITVIIMVAALEWLEFPPWIVVSIGSIGVLLVGSTCYGLLGLNVFKDGFVSLLAFVAVEMIQAGLKRLVNMWNRVAPFALNQTKSPGIPNQFLRTAGLLFEVKPDNLGLYTDHKMKAAAVFDTRKTYKLWSKCKGLAFILNNRNFPQSHLQRKGSEIDVENVKHLFTELGYEIISYDDLTGQEITRRFKDYASSFNKKGAEYDSAVVVLMSHGDEGLIYGIDLAVVRLKALQRELEADNCPGLKDKPKLYFVQACNGKLTTALPVVKDGPNASSVDQGPIQHYHEIPQVQPDNIDDRYLRDLADVHIAYCTTEGYYSLRSETIGSFFIQALCEVFFANAHRDNLDTLMNMVTDRVNDMRGKLFDPATKRWILVNQTPQCKKTLRKALYFFPKYFKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7W3</accession>
    <name>A0A8B7Y7W3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Target of EGR1 protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110977747</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with U1, U2, U4, U5 and U6 snRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087851.1">
        <property type="nucleotide sequence ID" value="XM_022232159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7W3"/>
    <dbReference type="GeneID" id="110977747"/>
    <dbReference type="KEGG" id="aplc:110977747"/>
    <dbReference type="OMA" id="RCCMPPT"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000039">
        <property type="entry name" value="Target of EGR1 protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF37">
        <property type="entry name" value="TARGET OF EGR1 PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="299"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022087851.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="59330" checksum="A4EEB55099C05E8C" modified="2022-01-19" version="1">MAFFSSVPVVDVHRENFKSLWPGLMLAIRSCSYIALDAELSGLGNRKNLLTRSMEERYHSLAEVAKTRSILSLGISCFKVRPQPMESKDLGLRFLAQTFNITTLCSEDYVVEPGSLKFLVDHGFDFNKQYASGVPYCRGVDKEGETEAEDSQTLRALFSELVKSSKPVVFHNGLVDLVFLYQNLYSQLPTALPQFISDLCEIFPAGIFDTKFLAEFEARMPASYLEYAFRKSQRANAHLATRGQQHVAMEFCQFENSSSVGFHRCGLPPSFTIRGGARGEERKTVELCETYAAHGHCKNGIRCPKSHDPDAIQDADDQREERQKRKRKRKRQKRQYDLKDGSPNAKKDKDEDDSCHGDREMDDDDEADTGKDQDEADTGKDQDEIDEKKESNSHGEDSEPKSAYGRGQGADILKIDQGGNEDSSTSLGQRDAASPQKLPKQTGGHRAGYDAFMTGFVLATVASNVAGRSGPSQPTDRETGQEFVQAFGLTEFRNRLFLSAKTVPLIIAKSKYAKTSQHHRQKMKQLGINPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9B9</accession>
    <name>A0A8B7Y9B9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110978003</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110978003</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088316.1">
        <property type="nucleotide sequence ID" value="XM_022232624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9B9"/>
    <dbReference type="GeneID" id="110978003"/>
    <dbReference type="KEGG" id="aplc:110978003"/>
    <dbReference type="OMA" id="RKGHCWR"/>
    <dbReference type="OrthoDB" id="10041188at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF15">
        <property type="entry name" value="LD37257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022088316.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="73233" checksum="5027A3C8309F578F" modified="2022-01-19" version="1">MDVRKGHCWRCEKPLPQKPLKCHGCPLAEYCSTPCKQQDKVRHGSVECEVFGPKRCTHCRKMGQTKECAGCNNAWYCNTKCQRDDWATHTMCRKTKKSLKEMAQFSRKCYAEIWKPEWRNGEPPVYIGNTIANDFLRLEGNEWSGLAEVGEEELYRDYHVLSVGCGDLRNTVLTVASLPARYQGKLHITLDDLDPFVMARNVMFLFMMVRYADRDGIASSLATIWYSVHISSDHYELIRKALQDLLQIRADNMPDRTAGLVRVWDADWSHLREVWEGWLALPCQRKASNSINLHQQRWDTFGANFFEIGFPQYLIRMPDKDLRFMREWIKHGLFLSKDMHQSRLTFDNPTLTGRPPVKNVFAETRQKLKTPKEYSFVYSVRNDQTPFNVWDCLRVDEQTGQQGLSVMVRYHAYVTQLLQKTIQFINQQRLIIHVFVANCLDFPNYHLTLRMPKYDRIFTSNLADYLGHCRLLKTFVPLLNSNNKHSTIVTQTMNWIARLMRKADILNQSPKDSAKYQQMCQQDTGFSPELSMSENNHVEYYNNMPWFLAYLRTDIMAGGVGIPVMDHAPKLSEVMQFEGLRMRDFRKELNRLVPFLYRINARKVTLLNGHERNVEWCLPDPTQEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAX7</accession>
    <name>A0A8B7YAX7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110979133 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090378.1">
        <property type="nucleotide sequence ID" value="XM_022234686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAX7"/>
    <dbReference type="GeneID" id="110979133"/>
    <dbReference type="KEGG" id="aplc:110979133"/>
    <dbReference type="OrthoDB" id="10383036at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="79"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090378.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27883" checksum="830BA30CBE2C1582" modified="2022-01-19" version="1">MVCRHRRSLAVYSLQTFAAVVKRTGPTAVRKCTVIMCSTLASVCGLLSQVTRQFSNTLMLVFTLVLCLASVIEGGMPAAPRNLTLVGQVLSKQVKISWVPGNPRDNLTDYVIVNRAQGSDTMTVSRIDPEYTFYTLKDLKEETSYIVYVKAAVGNVRSLSSVMLEFRTPRTEGLHRTFTTSAADLVIVVMVLALWLAALSLFVRTWRKKMSGAATSTGGTGTPLAMRLRSRYRKPWMWSQKYRPGRAYPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YD64</accession>
    <name>A0A8B7YD64_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cationic trypsin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110979204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090497.1">
        <property type="nucleotide sequence ID" value="XM_022234805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YD64"/>
    <dbReference type="GeneID" id="110979204"/>
    <dbReference type="KEGG" id="aplc:110979204"/>
    <dbReference type="OrthoDB" id="10012881at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034418532" evidence="8">
        <location>
            <begin position="32"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="34"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022090497.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="29438" checksum="2C1312B7E7BF11CC" modified="2022-01-19" version="1">MKQLAESTATFTMKFFISLACLLAVLTPTLGRLIVGGHESKPHSRPYQVAIYNRKDIKDHYCGGTLVHKRWVVSAAHCGKGHHGFAGLGLHDKTNHSEAGQQIIRGTWHLHPDYNGGTLDNDISLFHLGRDAHIGNGKIEAIRIAKTRPHKAMKLLVSGWGATASDGSARSDVLMEVVVRAQSMHHCRKVYGSSSITDNMFCAAASGKDFCQGDDGGPIVGHYGHGIHKNSTTLEGIASWGSGCADPAHPGVYVTVGNYCDWIKTTTKDAVQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YD66</accession>
    <name>A0A8B7YD66_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110978705</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089601.1">
        <property type="nucleotide sequence ID" value="XM_022233909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YD66"/>
    <dbReference type="GeneID" id="110978705"/>
    <dbReference type="KEGG" id="aplc:110978705"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089601.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16624" checksum="A649076EDA17F741" modified="2022-01-19" version="1">MCIVDLVSRFIFAFTGDVLPFQRIFLLAAGSALGAAGSFLLTRGTSLWIFVLYVVVAGVVRSIAYGLVWACVVDLFGADRTVEALTSIQISCGIGCLFASSVAGLSYDLTGTYQTTHFICIGLWALSSLCYAVVHQWSRITSCKINRSSHPAALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFD5</accession>
    <name>A0A8B7YFD5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Caspase-8</fullName>
            <ecNumber evidence="14">3.4.22.61</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 24" type="primary">LOC110979123</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala).</text>
            <dbReference type="EC" id="3.4.22.61"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.61" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022090365.1">
        <property type="nucleotide sequence ID" value="XM_022234673.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090366.1">
        <property type="nucleotide sequence ID" value="XM_022234674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFD5"/>
    <dbReference type="GeneID" id="110979123"/>
    <dbReference type="KEGG" id="aplc:110979123"/>
    <dbReference type="OMA" id="HFRTMNT"/>
    <dbReference type="OrthoDB" id="6116485at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01671">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00032">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000008">
        <property type="entry name" value="caspase-8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033139">
        <property type="entry name" value="Caspase_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016129">
        <property type="entry name" value="Caspase_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002398">
        <property type="entry name" value="Pept_C14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901">
        <property type="entry name" value="CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47901:SF8">
        <property type="entry name" value="CASPASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038001">
        <property type="entry name" value="Caspase_ICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00114">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01122">
        <property type="entry name" value="CASPASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01121">
        <property type="entry name" value="CASPASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="CARD" evidence="21">
        <location>
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            <begin position="360"/>
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            <begin position="97"/>
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        <source>
            <dbReference type="RefSeq" id="XP_022090366.1"/>
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    <sequence length="451" mass="50367" checksum="CF2054027E84DA6D" modified="2022-01-19" version="1">MEKHHKEALRKNRVALVQDMNLTYVFDALVERNIFEPADYEDFKEEGKTSRKINQVFLNALERRGPRAFDAFVDSLREHKQGILADILDPASAPKYPAQIKSRPGRVVDNPTDSLTGPQGDSKFEPMDTQPAKSVITSPTDDQPKVIWPGNSPALVTGMEMPASPIPPANQDASDIDNVYQMKSKPRGIAIIINNKHFRTMNTRKGTDIDGKNLNYVFEKLGFTTLVKNDQTGEQMQQIFRDTASHNHSTFDCFILAILTHGVEGAIYGTDERIVKIEHITSYFEGGRCPTLAGKPKLFFLQACRGERFDSGHEATDSKAVAPSDADATQDSIAPLSDEELAQRMLQRELEDDTDASNAIRSKLPSQSDMLLAYATVPGFVSWRNSERGSWFVQAMSEVFMEHAPKEDLLSMMTIVNNKVALAFESSSGRNKQIPAPVTMLRKKLYFNPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFU0</accession>
    <name>A0A8B7YFU0_ACAPL</name>
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        <submittedName>
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        <name evidence="4" type="primary">LOC110979602</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
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            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <location>
            <begin position="91"/>
            <end position="120"/>
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            <begin position="90"/>
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    <sequence length="169" mass="19572" checksum="B7860D93510156AB" modified="2022-01-19" version="1">MESQLREYRARKAREKMEEERSKQMGTWTHIWGTRATAESQDTRDMPLEATAQKLTTPTLNSPQEYVPRNYFLRFLAQDDSILTNLTFLKVLLWIVLFVLFLHLEFAAVFVVASFLYIIYSTLGTSRRRAPGELSAYSVFNPNFEQIEGTLTAAQFERELKYGIGSTNK</sequence>
</entry>
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    <accession>A0A8B7YG24</accession>
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        <recommendedName>
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    </dbReference>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
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    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF20">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 156-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034310229" description="Gamma-aminobutyric acid type B receptor subunit 2" evidence="14">
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            <begin position="31"/>
            <end position="1032"/>
        </location>
    </feature>
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            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
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            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="768"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="15">
        <location>
            <begin position="724"/>
            <end position="923"/>
        </location>
    </feature>
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        <location>
            <begin position="927"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1010"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="932"/>
            <end position="952"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022091350.1"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115322" checksum="47B03D7288A30D64" modified="2022-01-19" version="1">MLAMMWRLVSSVGILFILAGLTSLAHITTGETTPSTTSTQNAVTASWFDSGPVSPIIVIDPDNQTVTYASMAEDGTGPSSTAGYGVPRRNNKTAIYLSAYFTFGGGWDGSGILPACQMALEHINSRPDILAGYDLRMIWNDTQCEAGLGTRVFFDQLYREPQKIMILGPACSTATQAVAETAYYWNLVTMSYAAASSALSNRKKFPFFYRTYMPDAMYNPARIRLMREYGWKRVATIHENHELFSLAIDNLLTLLKEANITIISSESFSEDPQNQIENLKNQDAKIIIGNMYEDKARRVFCEAYRHGMTGADHVWMIIGWYRENWWMDKDPNIKCSALEMKLAVEGVQYFSTESLQLSTSTEPTIAGITPAEYQSLLRNRMEWPENRGYTWNSLSPYGYDAVWAIALALNKSVEVLKSERYGRRLEDFTYDDREMAELFFKLLNETEFTGVSGPVGFKEGDRVGITQIEQLQASCPDGWHLYLSSCFRFVSQPVLPYERAGNFCAAFRPDAALAHFDSQLDHEFLISEWTSKPEAAPDKWLVSVLPKGASEVNASWIPAGSSPHVTEDGACVYMDFEKGGILEIADCDALFPFICRVAADFAERQVALYSAMNDDIEWRRDIVWQGDGPPLDRPPQIVVEIVRRYQGISSVLYLCLCGVTAVCIILSLFFLVFNVKYRQQRHVKMSSPNLNNLIILGAVLVYLFVVISGLDTNIISEDLFEIMCYVKTWILSIGFVLAFGAMFSKTWRVHRVAAFKTPKRRIVTDRQLFVMVFVLLLVDVIILIMWQVIDPVKLQSEDLYQQDDPEIPNRIIQPFIRYCSCDTLTYWLGALYGYKGLLLIFGTFLAWETRKVSIPGLNDSKLIGVSVYNVVILCVIGAAVSTVINSNPEALFVFVSCIILFCTSITLIVVFVPKIIAVVKYPDGDPTQPAARTRTNNASETSSTNTSVTTENKQLKARIQELENRIKEAQGHSQSSMHPGAAEGCGCWSCGLVCGFSASREKDYGADEAVPAEIHSQPVDMEEPAGVSTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHJ3</accession>
    <name>A0A8B7YHJ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">RING finger protein 145-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110979960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091865.1">
        <property type="nucleotide sequence ID" value="XM_022236173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHJ3"/>
    <dbReference type="GeneID" id="110979960"/>
    <dbReference type="KEGG" id="aplc:110979960"/>
    <dbReference type="CTD" id="153830"/>
    <dbReference type="OMA" id="SPWKHFR"/>
    <dbReference type="OrthoDB" id="4752984at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16476">
        <property type="entry name" value="RING-H2_RNF139-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025754">
        <property type="entry name" value="TRC8_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF191">
        <property type="entry name" value="RING FINGER PROTEIN 145 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13705">
        <property type="entry name" value="TRC8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="532"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="577"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022091865.1"/>
        </source>
    </evidence>
    <sequence length="608" mass="68751" checksum="909577113568A67B" modified="2022-01-19" version="1">MEISQLNLRIWRFSNVVLRLPSVFILEAIHQSRRSKSRLSGSTESLASHWGLEPETVTIGSQYLGYFVVFLLHALPLRMLIKLYKFIVVGLMLLAAHLLSAYSLSVRATDSHSSFPSAVTFALAQGVISLMCAQLMGTKHVWAFAAYVLPQIANLSGLPLDAQKLAHGVAQAVTLAEVSVFTLRHVLVPYRLALIGYKTLQEYVELYGIISVIFALYNRFFVPMLYLIFWLVLFAHRLYVYYSTKDHKIFGERWALVIFAAIADCCESPWSLLGLCYTVSYTAFLVLLLCKMYLKGFNSLGGETFLHRGWTEGITVMLLAMETGLLELKKLERILLLSVLMYIALSSTIQSVYEILDPVLLALAASNDRSPWKHFKALSMCLALMATPLYLSYMLFAMFEAELWLMIIVSSCLLTTVQTFGSLTIYLLFMADHRRSTSWESLDDVVYGIHAMCHVLEFGIALSVLFYGGMESFHRDYNLLGAAVILVHCYFNVLQRAQAGWQSFLHRRDAVRKIKSLPTATQEELSSLRDVCAICFEEMAFAKVTPCRHYFHSVCLRRWLYVQDKCPLCHKTIIPEMPKPSNGGGDPEEELPRQPHQDLGQGDAMMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJR8</accession>
    <name>A0A8B7YJR8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110980809</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093498.1">
        <property type="nucleotide sequence ID" value="XM_022237806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJR8"/>
    <dbReference type="GeneID" id="110980809"/>
    <dbReference type="KEGG" id="aplc:110980809"/>
    <dbReference type="OMA" id="NENCCNA"/>
    <dbReference type="OrthoDB" id="6051518at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19359">
        <property type="entry name" value="TenA_C_Bt3146-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050967">
        <property type="entry name" value="Thiamine_Salvage_TenA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198">
        <property type="entry name" value="BIFUNCTIONAL TH2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43198:SF2">
        <property type="entry name" value="SI:CH1073-67J19.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="74"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093498.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="28703" checksum="A34235070578E63F" modified="2022-01-19" version="1">MSVWQKGLKNIRSPRSTAAMLEHLPQTVIDRLAAKHPAKLTKVPVADGRYEEKELSEWLWESSQVQAQLALHTKFIQGIKSGLLDPTDYGGYTVQDAVYCSNATTYYGIAEDKSQDEIMKAFIQSRVKSYTSYTKVMFKQWHIRDPSGVAMGAAAASYSAFEKGVAENCEPIYLLIAMLPCEKLWEWLAEQIQSGISETNVYSFWITDNLGGSSKLAHFIDAYADEYGVDLQKAKDIYHGAMQGEVNFFASATAEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLU0</accession>
    <name>A0A8B7YLU0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110980883 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093617.1">
        <property type="nucleotide sequence ID" value="XM_022237925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLU0"/>
    <dbReference type="GeneID" id="110980883"/>
    <dbReference type="KEGG" id="aplc:110980883"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093617.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="37435" checksum="C4B72B6601A814E8" modified="2022-01-19" version="1">MWDSIDSHSNIWTPNHKQLFIKRRFVESYLLEPLVLHVCLDCCLPTFFLLQNGSLQRHWNSFKVGGEPVTRPFGVNHTFVGFDRMPSDRYSTQHVLSFCLICLLLSCAVEQAGSTDNVTEGVRARYPNPWQDPEQCRRTDTEKSWICDVDGVLPKEQADSIDSLLVSINANASCVCNCSGNTTFLFADEGYVMGVAVVTSLEEDLSVANRTYHLERFGESIRQDWFANRTCDDSILILVHYMYNCSKIHISIGVAFDNLLSSQSLSSIYEAAQPSLGTGNIGQALPITVQKLDAVIDKAMTTPTEPPPPNNLVWGILGVIAVTSILLFHYWIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMI8</accession>
    <name>A0A8B7YMI8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="8">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110980912</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-hexadecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-hexadecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70563"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:14175"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138936"/>
            <dbReference type="ChEBI" id="CHEBI:189673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:70564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-tetradecanoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-tetradecanoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:70567"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:15437"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:141129"/>
            <dbReference type="ChEBI" id="CHEBI:189674"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:70568"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022093670.1">
        <property type="nucleotide sequence ID" value="XM_022237978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMI8"/>
    <dbReference type="GeneID" id="110980912"/>
    <dbReference type="KEGG" id="aplc:110980912"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="14">
        <location>
            <begin position="29"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9 12">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="139"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="258"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022093670.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37583" checksum="6E382F49B53075D9" modified="2022-01-19" version="1">MSELEEVTQRFLHHQSAAEKFETSETPQRVLDEVSLEGVARYIKSGNCKNIIFMTGAGISTSAGLPDFRTETTGLYDQLQEYELPNPQRMFEIRYFKERPEPFFKLVKSLYPGAFKPTPSHYFIRLMCEKNIVRRNYTQNIDTLDKIAGIEEELIVEAHGGFSTAHCIGESCLTEYPALWVKDEIFADRIPKCNQCGAVVKPDCAFFGEDMPRRFEHLVVEDFSKCDLLIVAGTTLVVQPFASMIHKVPASTPRLLVNYELSGKADPLMKFMGRGVGFNFGYTDNYRDVFYWGSCDEGFYRLAELLGLKEELERLIKTEHQKLDAAASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMP7</accession>
    <name>A0A8B7YMP7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NXPE family member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110980948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093725.1">
        <property type="nucleotide sequence ID" value="XM_022238033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMP7"/>
    <dbReference type="GeneID" id="110980948"/>
    <dbReference type="KEGG" id="aplc:110980948"/>
    <dbReference type="OMA" id="MYIDVER"/>
    <dbReference type="OrthoDB" id="5950832at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026845">
        <property type="entry name" value="NXPH/NXPE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165">
        <property type="entry name" value="NXPE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16165:SF5">
        <property type="entry name" value="NXPE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06312">
        <property type="entry name" value="Neurexophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022093725.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="40033" checksum="FC02625655168DD1" modified="2022-01-19" version="1">MRRIRIRFRLFVLFAMPVLGVILMLGYSALSLADRDLPWNDPAVHMKYRVHHAVTPAAWPSFNLIPNARNTRNIARRVPGPVAKGLPGRWLHQRGNMGLTSFRTSTLSLVPATVKEGQMFRVMIEARDQNNRPRNMGGDFWCATLTTKGGGYTAGRVLDHSNGSYSVYFFAGWSGTANIDVTLVHPSETVDYLVHTVWHAYDRIVWLGRFEEGDKKSTTTCVLRRGGPWTGKCELSHPYALGKTVLLCDQPAHGLKCDSIVAVYNNNTRIRERASELTAGKEHLFQGDYYSRKLKDTPKTINIANTTTSNRDHLMRQIPVCEPDQPRPLSSGYWRDSETWVSLACRSRQKMNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YP74</accession>
    <name>A0A8B7YP74_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Serine/threonine/tyrosine-interacting-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110980667</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093250.1">
        <property type="nucleotide sequence ID" value="XM_022237558.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093251.1">
        <property type="nucleotide sequence ID" value="XM_022237559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YP74"/>
    <dbReference type="GeneID" id="110980667"/>
    <dbReference type="KEGG" id="aplc:110980667"/>
    <dbReference type="OMA" id="RFCVVYD"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001691">
        <property type="term" value="F:pseudophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062030">
        <property type="term" value="P:negative regulation of stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001244">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053272">
        <property type="entry name" value="STY_interacting-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
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        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING-LIKE PROTEIN 1"/>
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        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
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            <begin position="143"/>
            <end position="287"/>
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            <dbReference type="PROSITE" id="PS50054"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQ43</accession>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
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            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
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            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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        <property type="nucleotide sequence ID" value="XM_022238883.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="83"/>
            <end position="138"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    <sequence length="138" mass="15299" checksum="5A0DE2E860C82B64" modified="2022-01-19" version="1">MAYLQGDDDEDLPPIERPVMDQQEIAETGEGLVSNRFTVSESFKKLESGEAPSIFSGEKTGRETVFKKKAPEAPKPLQSYDARMCAICGEKLKGKFAKVQGRGVHFDCFKCSVCGDNLRGQGYFGGDGVYYCRKDRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQJ2</accession>
    <name>A0A8B7YQJ2_ACAPL</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="13" type="primary">LOC110981859</name>
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        <name type="scientific">Acanthaster planci</name>
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        <lineage>
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            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="nucleotide sequence ID" value="XM_022239846.1"/>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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        <property type="entry name" value="LDL_receptor-like_sf"/>
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        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
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        <property type="entry name" value="ShKT_dom"/>
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        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21724:SF109">
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="1731"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1795"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1880"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="1961"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="2046"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="2218"/>
            <end position="2252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022095538.1"/>
        </source>
    </evidence>
    <sequence length="2291" mass="255833" checksum="7D5E15FFBB350C25" modified="2022-01-19" version="1">MKLRSLLILLLCVLVLVQTADGKKRKRKKPKVKPTTRAPTTTTTRAPTLQTDPSTSYTPQVAGACRRTCERNSYLMPDRCVCVCNQGYEYSSRTGYCEDIDECADESNCVGGACTNSRGSYYCICPVGYNLHANGKLCLLEPRVMSCRGLVCFDGAELDELRCRCWCSDPGLTYDYFEEKCQDINECVAGSHNCEHGCINTEGSFMCYCVSGFQLDADGTTCLPSPPPDPSTIPCFGKCPGATALNLLNCNCMCETGFVYGEDELECVDRDECRDYQGWCQGVCENTPGSYTCTCPTGTVLDADGWTCNEPVSSSGEFECFDYEILCDHGNQCVQEGVICDGYSDCSDGSDERQCKPVCRPDQFSCANGRACLEATQRCNGENDCLDFSDELDCPCKDEKDECHAWRNRGECESNPGWMNWNCRESCKTCMKDDGTESGVVEESELPMLFFLRNSEDFASTLQYTLRNTGNREGASGSEWLCHTVTEVPIAVRAQFRLSYAYRKYAQAYNIPILGTARANEDAMTRACYVVRFLLADRRDLREALYRAWGRIAVMDDDEVTVNIPEHSHLPELYNSLRGLGGTLHIPVASGATENLICLENDPNSGQDMFVHTMAHTIRRVSITTMTSTYNSRLLGAYVNARKTDLWANTRAQYTADEYFAQGVMSFFNVITDSEIDSREKLQRYDPALYNLVKEVFPCMNTIVDRCDADQSKIYTEQIRMNCNERGEPDRQLDPDTMAEDVCRNLHHECPQWKNDGGCQNNAVWMSTHCPKSCGTCPEPEEEPVDGPSIELGRDDEGNIKFKEPSDCQDADDQCLQWVQEGRCETHAGWMEIFCEKSCSMCEDQEEIVLRDNDSDNEEQTPLPPDEAQCVDSHFLCEINAKAGECTTNEFWMRKHCPLSCHFCIDISVSHFTCQDSDPVCHELAKEGNCEVEWIKANCKKSCGTCPATEEKTTTSAPTPVPVDEYTCVDIDPICTEWADEGECMNNPRYMEENCPVSCSYCSNSETKEEQSQYEFIPTPANEPESVCADLEPHCIGWAESGECVYSPEYMQVNCPASCGFCKGPGVKPVKPNCVDHDRYCPDWASEGDCATNPEWMLVNCKLSCGICDDPLIPADSDCFDTDQYCVDWAESGNCETDRHWMFVNCPQSCGLCDGSQIPPKPTISTQTSSYHYEPNCKDSDALCPGWAFYGGCYQNPEWMLPNCAYSCNSCHYIVTNDTQVDPEPSEQPLSCSDKYARCQDLATTGGCLTIPEWMTEHCPVSCNMCGDREIVTHLPPPAKTNYPTDDENMAVTSTASLGEVEESENSDASEWTGDWIHTSDSWRESQITQVWEDSQSDDSSDDNSDLTAEASMIDIPEEGFSINTGVFTNEDVTQSPVSVSKSQDSITVPGSVLSTKITEKMSTSRDESAQPPNSVTPSFHSFTSLSSSLTDSLGEVPPTVFHEVSKVQTTDPVTRDKQLPKTDGKFTESLTQVLSSSPPPYVTKPQKELTWKSTSGTTYRTGRTTEPEWNPHQRTPKYITSSPRMSTISFQKGGSMPTSTNDKHLFTEATDKLWSNPTPTQRTIPVTVPAIGSSSVSTIDYRETSTDDLADKNVRVPTATTQQNDSHSFTSEYKTQTFISEVVTINSNRVTQVPEEEYTLSTLADTDLRNDVSDSKNTQSSNILTTSKHLQYHTTLEQLLHKLTPIPPENGTPVTLPEDTTEQTTVEMSTFLSEVLKISTTEQPVVKSDCNDKHKNCPVWAFHGSCISSSSYMHHNCKASCNLCEATEDESILPQRTTSPIITNSLDEGSWLDCKDSSKYCSVWASYGGCTSNPRYMLPNCRRSCNSCDFISSLAEEVDDNISGSDNDNLASFNDDESFIPTAPPSGDMTTSWAINKDCKDTIAFCTTWAKHGGCTENPEWMLPKCRKSCNSCDFVEEPKDTLSESMDESYSEPTSLYETTTKRVPVTQSNNMKPTDPSCADSNANCEYWGSIGECAKNPVWMERNCQKTCHTCQNFWSDCYDDYGPACEGWANIGECEANPYWMKKNCRKSCHTCNDTFNEDLCADNYEKCPKWKEEGECDYDVDWMRSNCKRSCGLCALAKDEKQCLDSFDNCTQWAEDGECDGNPVWMRINCCLTCLEREPTYCVDKDERCVQLRKDGACNFDREWMLEHCRMSCEACNISNVNIPHPRKDCVDDGDYCAELALEGECETDREWMKDHCCHSCSLMPEDFIPGCADTKRDCSKWAEAGECDTNKNYMTIHCAKSCNKCSECIDTDDSLCLELASKGQCVADPGTMLAYCPKTCNMCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRL3</accession>
    <name>A0A8B7YRL3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pancreatic triacylglycerol lipase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110982079</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095919.1">
        <property type="nucleotide sequence ID" value="XM_022240227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRL3"/>
    <dbReference type="GeneID" id="110982079"/>
    <dbReference type="KEGG" id="aplc:110982079"/>
    <dbReference type="OMA" id="MWYGKFW"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034909392" evidence="5">
        <location>
            <begin position="20"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="70"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095919.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="39847" checksum="1CC9815397560E3A" modified="2022-01-19" version="1">MGIVANILVLALGFLVSSANEADERLFDNCGCNISELDPDHECTGSFSPVTYPEVGTFTADLWCHRRGFPPKHPDEIGTTFRLYTSKNPSSPTVISTSSLGYPFSASSPTKFVIHGFTDNGEKDWVLNLKDELLKKGDFNVIGVDWEKGATAGFIVSGYCQARQNIRVVARQIANLIKKMQSSFSEFDLDDVHIIGHSLGGQMAGYVGEEFGGKIGRISGMDPAEPEFEGDETGCRLDPTDAKFVDASHCSMYGIYQPVGHVDIYPNYGTHMPGCVIWPNLMEAECGHLKAIDYFTDSINNDCSALAYPCTWQNGQEQGCKYSGQSGVSGVKFGYQADQTPSSLYGLYTMMTNENAPFCDPNTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YU90</accession>
    <name>A0A8B7YU90_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110982138</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096040.1">
        <property type="nucleotide sequence ID" value="XM_022240348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YU90"/>
    <dbReference type="GeneID" id="110982138"/>
    <dbReference type="KEGG" id="aplc:110982138"/>
    <dbReference type="CTD" id="3421"/>
    <dbReference type="OMA" id="DGVHTYD"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF60">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="66"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022096040.1"/>
        </source>
    </evidence>
    <sequence length="401" mass="43469" checksum="E733B3219C057735" modified="2022-01-19" version="1">MAAPTVFRGVGLGLSKISKTPLSLCRESRLFNAVKQPLCIAGQQLSSTRQHLTSEHLAARYGGWHTVTLIPGDGIGPELMAHVREVFRHADAPIDFEELMLSGERASVEGEGVEDALVAIKRNGTALKGNIHTEVNRLAVCKSDNVRLRVGLDLFANVIHCKSLPGLQTRHSNIDIIIIRENTEGEYSSLEHESSNGVVESLKIITEERSKRIAKYAFDYATKHNRKKVTAIHKANIMKLGDGLFLESCRSVSKLYPKIEFGDMIVDNCCMQLVSNPNQFDVMVMPNLYGNIISNIGAGLVGGPGLVPGQNIGEEFAVFETATRNTGKTIAGQNVANPTAMLLAGCLLLRHLGLNQHADLINAAVMKTVTENMVHTADLGGVATTSDVVEGVIKEIQAMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUF7</accession>
    <name>A0A8B7YUF7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sphingosine-1-phosphate phosphatase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110982172</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096115.1">
        <property type="nucleotide sequence ID" value="XM_022240423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUF7"/>
    <dbReference type="GeneID" id="110982172"/>
    <dbReference type="KEGG" id="aplc:110982172"/>
    <dbReference type="OMA" id="MALIWPW"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:sphingosine metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="10">
        <location>
            <begin position="160"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022096115.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50048" checksum="DB0EC8FF97B690CE" modified="2022-01-19" version="1">MKSKTLPKMKAIPEASLPLYNEEYVAQLQRFFGLELASKTADNGSLPTENREERDSSAAAAIADDLTSNSNQACRVHDKDRETTYFSLKQRKAPEVEKCDGERDREEGPTDGVGPDPPDRYRVHSRFWYAIFSFGALLGDDTFYYFIFCFSVANLSWWVTRRLLMVWGFCMFIGQACKEILRWPRPREPPVVQLESRYNKEYGMPSTHAVVGTLMPFTLLISTWNHYEYPHLLGFVLACNWTLLVCCSRLYRGMHFILDLIAGVTLTALLMALIWPWLDSLDHFLLTHPYAPVIIVVVTILLIVFYPALDGVGASRNDTVSILATMGGGLCAFWCNHRSGLVPDAHAPLGGTIDWPDLPTAGIMLVRYAIYTVIASIIFFGLKFLIKRMMQVFFGIQVNRETKRWLRVQLSYGYVPHGFTMLVMYSMGPRLCTWLGLDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW77</accession>
    <name>A0A8B7YW77_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Stimulated by retinoic acid gene 6 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110981873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095556.1">
        <property type="nucleotide sequence ID" value="XM_022239864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW77"/>
    <dbReference type="GeneID" id="110981873"/>
    <dbReference type="KEGG" id="aplc:110981873"/>
    <dbReference type="OMA" id="FWITITV"/>
    <dbReference type="OrthoDB" id="2376984at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034632">
        <property type="term" value="F:retinol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071939">
        <property type="term" value="P:vitamin A import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026612">
        <property type="entry name" value="STRA6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF15">
        <property type="entry name" value="RECEPTOR FOR RETINOL UPTAKE STRA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14752">
        <property type="entry name" value="RBP_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="174"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="506"/>
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    </feature>
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        <location>
            <begin position="710"/>
            <end position="752"/>
        </location>
    </feature>
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        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
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            <begin position="737"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022095556.1"/>
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    </evidence>
    <sequence length="752" mass="84685" checksum="7BD5F3AFA0440BB6" modified="2022-01-19" version="1">MSSAANKTCIIAEYRGSLVHGSFPFAVCIILVLSYIQRTKKERRPGDSRNPLRDVFSLLYPIDLFDNHDRLPHCLAFGAASSLCLDLLFGDYQSYFFAWVMPAWAKILIGTIVTIEIAVDCFPFFACITCKSRLLANGIGFLYLSGWFVLLILISIGCENREAKGQVPVLVPQIPVLICLFLLVFYFLGMFIFILIQRRRGITPTSQERLYKTHQAIYVRNLLNKPREVVYTGWRAKLAKYYKPHPGFIYPTRVLMPCFVSIIALYQIAFWLIPLGLNLIDAAYGLAVKLAQQNFPNPNATIYNETLEDIMNKLDQAHTGLTVCWWIAGVMSVCVVPLLYIPHILKNYRKHLLSMWSGQYNLPTSVTLTSTDSIVGSMKYIGFQVAVFIAGCMFVQGFLTFLLIALTFFGLFSSWFFEEFFVNSVVEIIIPSIIVGTLVMSSQGIVVKKFFTQDKLKPDDADKPLSLQHRAWFLLYSYVTLFLNLLYGLIFAVLRIVIGVIISVILLPRIDRPIWAPGVGDKDLVYVLYAGNLYTENAHSNPILVMFCHLMVFDILNPKRKQLRMSQLHRQMSDKGLINSQAPSYTDLESTSTETERPHLLRFFRWHLAYTLINNPSVIRLRKSTAVLPDQEVMISEGEARFVNAGKGNRGHQMLPHMMEVMKRQNSGLRDMSEVAPTVTRPSVNAVDPELIVIEDLPAIPQSPGNSSLLVSPLLPIEDSQLQSGPTSEPGNPAKPARGEKGLHTADSESTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWA6</accession>
    <name>A0A8B7YWA6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Echinoidin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096967.1">
        <property type="nucleotide sequence ID" value="XM_022241275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWA6"/>
    <dbReference type="GeneID" id="110982680"/>
    <dbReference type="KEGG" id="aplc:110982680"/>
    <dbReference type="OMA" id="FPERIWI"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034129408" evidence="2">
        <location>
            <begin position="21"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="30"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022096967.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27713" checksum="3E4A7CED136C231F" modified="2022-01-19" version="1">MDMSAFEAIVFLVGLYASQAAVCPADWRQYGDICYFPITTSMSWEEANQACFAKEAQLALPRSQMEQDAIWGMLQETVNGQFPERIWIACSDFEEEGNWRPCPLRDDGSNAYENWRGNQPDNNNGADCAAMIRSNGGRWGDRPCRELNFAVCQLPAILMSVPTVCLLINTDGRPASACLVGHNLKEIPVTGVVECGMACRLEPRCRSFNLVKQGRAGMLCQLKNVTWSEADEKSFMKTQENCYFFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWK8</accession>
    <name>A0A8B7YWK8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Octopamine receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110983085</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097704.1">
        <property type="nucleotide sequence ID" value="XM_022242012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWK8"/>
    <dbReference type="GeneID" id="110983085"/>
    <dbReference type="KEGG" id="aplc:110983085"/>
    <dbReference type="OMA" id="WVGWCNS"/>
    <dbReference type="OrthoDB" id="5955450at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14967">
        <property type="entry name" value="7tmA_amine_R-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000929">
        <property type="entry name" value="Dopamine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00242">
        <property type="entry name" value="DOPAMINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="34"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022097704.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="40934" checksum="750CF8DCA0A2FA45" modified="2022-01-19" version="1">MEDAPATENPDSVGASSVFGAPALLLVILAGILGNVLVCVAVIQFRNLRTVANSYVVSLAVADVLVCTAVMPLALYLELTGGMWFLPGPLCKVWGAMDIMLSTSSILHLCTISIDRFNAITKPIEYVTRRTAKMAFGRMAIVWVLSALVSVPAFALFQKENDACILVDSTNAYAWCSSSISFYIPCVVILIVYFKIYSAAKRRARRVINPTPLSTVSANPRLQQSASQSSFQDGGQSDRLSSSAIEGAPDSAMPGQPVSRGIPLQGVVPVAAMLSIRAKAHCRISLAQERKAARTIAIVVGAFIVCWLPFFILHSIFNPVCTSWPEGLSCEAVPTLYRIFTWVGWCNSSLNPIIYTIFNREFRQAFKKLLSCRKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXE7</accession>
    <name>A0A8B7YXE7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">hypoxia-inducible factor-proline dioxygenase</fullName>
            <ecNumber evidence="9">1.14.11.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110982901</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:48400"/>
            <dbReference type="Rhea" id="RHEA-COMP:12093"/>
            <dbReference type="Rhea" id="RHEA-COMP:12094"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.14.11.29" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022097362.1">
        <property type="nucleotide sequence ID" value="XM_022241670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXE7"/>
    <dbReference type="GeneID" id="110982901"/>
    <dbReference type="KEGG" id="aplc:110982901"/>
    <dbReference type="OMA" id="TWLEGNE"/>
    <dbReference type="OrthoDB" id="5952526at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160082">
        <property type="term" value="F:hypoxia-inducible factor-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051559">
        <property type="entry name" value="HIF_prolyl_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907">
        <property type="entry name" value="EGL NINE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12907:SF26">
        <property type="entry name" value="HIF PROLYL HYDROXYLASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="14">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="15">
        <location>
            <begin position="295"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022097362.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55295" checksum="981811EDF324A54D" modified="2022-01-19" version="1">MAESVKSSVGSCACCKSTENLKRCSKCKSVFYCSREHQLQDWKKHKRYCKKISSQESTCMVDDGAHAQLGNVSAAAEQEHDKHWVIKGANVPNHSGSVNTNSKCYSSRDVVKSADSKTSTANPVKFSKNNTNEKKKLSSQREQVGLKVKHDKDGTQQNGSKSSTHFDSRPFIQMDFPLPESRDRDAMARHTTVHLQRNGYCVLDSFLASESSRSILREVKSIQDSGVLIDGPLSGGRTSSEKSQKFIEKAIRGDKITWLQGNEACYPSISALASRMDELIQRLNYYLQDQYVISGRTKAMVACYPGNGAGYACHVDNPNRDGRCITCLYYLNDNWDVEKQGGLLRLFPVSGGYVDVEPLLNRLLLFWSDRRNPHEVQPAFDKRYAITIWYFDKKEREEAKMAQLNEDMSKLRGEVCLPDVKSQKERQDRIEQEIQETSSKAVAGLSHLELQGLSAMLEGQPDPRAVLTQLGVAPTIQDALLRQLKEMKSSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXW0</accession>
    <name>A0A8B7YXW0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110982885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097330.1">
        <property type="nucleotide sequence ID" value="XM_022241638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXW0"/>
    <dbReference type="GeneID" id="110982885"/>
    <dbReference type="KEGG" id="aplc:110982885"/>
    <dbReference type="OMA" id="FNFLNWY"/>
    <dbReference type="OrthoDB" id="10056177at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="12"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022097330.1"/>
        </source>
    </evidence>
    <sequence length="575" mass="63991" checksum="ABE2E3031D7DE9C9" modified="2022-01-19" version="1">MAGLFHIHPPLLVYKVFNFTFWGSLACFLPYISLYFKQLGFSPGSIGTISALRPIFGFLLLPFTAAAADRFRCRKAVLVASVVLSGAVLLSFAVLPRGSQVPCDVMEEQIWEMLHLNISLPYQEDQTRYNFSLDGDIFSFSSTSVLKRGIDRQVTRRALPKVALGTWRNQTTEGSLGQFPKPIQEALLANQGWLYEKADLRTLFVVILLISSFIEVVVFSSTCQADIATLDALRREYGHVDHYGWNRGFGTLGWGVCSTAAGFILNATRTVEVSCGIEHTIAGYWTSFLLAVGVSSIALVCVAYFKFSYDSKTGDTESSYGPITAVLLSWHYGSVLVMLAFLGLCNGCVWGFLFWHLENLGATQDLLGIFTAINSFSEFSCGFLSSWAIAKFGHVTLLILGLSLYILRFVSYFLITMPWTAVFIEPLHGLCFIMTWTTAVSYMTETVPTLYGGTMQGVLISVHHGLGAGLGFFLTGLLVTEYGARMTFLLYAVSCGMFLFLFLLVQWLSRVPTLEWKSEEPVKSPPDKHEETDEEQMQQTQSLLDSPGDRQNSKLSLKLPKFVLTTKAINQQELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZM0</accession>
    <name>A0A8B7YZM0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983672</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098798.1">
        <property type="nucleotide sequence ID" value="XM_022243106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZM0"/>
    <dbReference type="GeneID" id="110983672"/>
    <dbReference type="KEGG" id="aplc:110983672"/>
    <dbReference type="CTD" id="4698"/>
    <dbReference type="OMA" id="ENQWKWP"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098798.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="13020" checksum="8C33C6504775B024" modified="2022-01-19" version="1">MSGALKKSTGLVGLAVEAHPRDKLRVLYTKILGILQTVPKEAAYRQSTEQIVNDKLNVVKSEPNTEKLEMKINCGQIEEAIRQAEAELSLARKMVEWKPWEPLKEDAPPGQWKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2F0</accession>
    <name>A0A8B7Z2F0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110983850</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099147.1">
        <property type="nucleotide sequence ID" value="XM_022243455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2F0"/>
    <dbReference type="GeneID" id="110983850"/>
    <dbReference type="KEGG" id="aplc:110983850"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="2">
        <location>
            <begin position="72"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099147.1"/>
        </source>
    </evidence>
    <sequence length="182" mass="19952" checksum="F1D4216664A8CE14" modified="2022-01-19" version="1">MWGVKTLATFGSATARLFAGCNEFKVGSSVVEVAAKPSTMALRGKLVGLVLVFGGMLSVSANDVEEMGQEIYEETLESGLYPGNEFRTKLYLHPGITWFRITLQNKPGNPLINASVVALSIRVDIDVSAGFKGHIERNWLDATGASQLNPSESSIIGEFPFYLDYVFEVVLYSGLQDFERFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3E2</accession>
    <name>A0A8B7Z3E2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ homolog subfamily B member 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099295.1">
        <property type="nucleotide sequence ID" value="XM_022243603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3E2"/>
    <dbReference type="GeneID" id="110983926"/>
    <dbReference type="KEGG" id="aplc:110983926"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF14">
        <property type="entry name" value="PROTEIN DNAJ, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="9"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099295.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41976" checksum="57E3B61EAD695956" modified="2022-01-19" version="1">MSSLMSRRECFKILGLPPDASPEAIRQAYRTKAKDCHPDKNPDDPEATARFQKISQAYQVLQKDFRDPTFEDDSAYSGGGFSFLDLLLIFQREMLLEEIRRREAMRRQAVFRNLFGGPFFSPRMRIFDDDDDDYDVYYDSSDSDDFSFCSDYIPRRERTPSPPWTSYTSRRPQQQSERAEARWSASEAKKTTDWSEACRGSSKADCGTSGQYQSFSYRSFKSQQEKHDERPENKEAVRDPPTDAGTKHPRPNEPGENTTSLTEEVIKDTEEAFSRAAAGEWDQCFKVPVKSHQDKSRRKPRKTKTASTYAVNVPMKMTKKQLLAQQNRRQKEANEIGKELRAKAEVNMKLKEQLKNSGKGKGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z447</accession>
    <name>A0A8B7Z447_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TIMELESS-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110984168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CSM3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099737.1">
        <property type="nucleotide sequence ID" value="XM_022244045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z447"/>
    <dbReference type="GeneID" id="110984168"/>
    <dbReference type="KEGG" id="aplc:110984168"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="8">
        <location>
            <begin position="106"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="49"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="242"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="409"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="565"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022099737.1"/>
        </source>
    </evidence>
    <sequence length="583" mass="64878" checksum="2EA261B4CF0EA44D" modified="2022-01-19" version="1">MPTEGAIRHQFPRNPKAQFKEHRVSFIRKISRMQSMDVLGARDGYISDEEFPPLAELPPLSPTRNDLDLFAENTNNASDNRGDEDKENEGDKQRPHRLVNRKPQPKLDAVRLCSDRGLPMLSKHFEQVKFKGKGHEVGDLNRLMSTMEHWAHRLFPKMPFDEVIDRIEKLGKKRAVQTCIKKIRLDMPLMDEDFVEPEGGTDAAGTDVANDRVGDEDEMDTFSQFAGQLSQPVGTPTNANVLLSEEQRERMEQNKRRAMERRKSKGQATPASDDLGITTDELQDLERYHANDEDMEKELWNDIAMFEASQRNIWKVLPRKTNGHPQKETDSTQMPARKQMGTGGREDIKGISKDIIVIDDEVSEDEADQMQGVKETRALETTDINEAGGPGDGMMTDSRQNVIDLDADASDKEGRTSAGEKRDEVAETIDGDWEDEGKGSQDEMKDDGEGNRSSDLVLKWDSESADESTTVLEPSDEAGAKVTETTNDTEFGETHVHRAPAEDGQDIAELPSSKGQEAGASRDSPEDKISQDSAGETVSESRSDGEVGKPVGANVVTLENGTDREGEEVGSTEQDTVEDMETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5J9</accession>
    <name>A0A8B7Z5J9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G-protein coupled receptor moody-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110984745</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022100908.1">
        <property type="nucleotide sequence ID" value="XM_022245216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5J9"/>
    <dbReference type="GeneID" id="110984745"/>
    <dbReference type="KEGG" id="aplc:110984745"/>
    <dbReference type="OMA" id="RFASNIM"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="51"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="235"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022100908.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41235" checksum="2D3F0548D8DACEBD" modified="2022-01-19" version="1">MAVAITNETLPIVEVNTTEDPTTTNPPLYSYQARIGFGSCWLIIAILGLVGNSLVILSVILSKKLRTVTNAFVVNLSVADFWTSLSYPWEVVAVLSQGSWSFTEVPCVIAAVQLYTGLGASLYSLAAIALNRLMLITQSPETYGRWYSPGKVSIMIALTWAIPSVVFFLPPIVGIGAFGYDPTDNTCSDKDAHPRGPEYNLAQSLGLYPIPMLIIISAYTALYIHLRRHFKKQKQRRAEYSGPSQSSGTAAAESPPSFSVVTESSAMPSSDRARRNRRKISRQQLAITKNLFMVFCVFFLLVSPYFISLAIPTSRPFALYGLTISMLNSCVNPIIYTANHPHFKGVLRSILCCRYSQIPEPSDWLKSVLSRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z671</accession>
    <name>A0A8B7Z671_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110984861</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022101134.1">
        <property type="nucleotide sequence ID" value="XM_022245442.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101135.1">
        <property type="nucleotide sequence ID" value="XM_022245443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z671"/>
    <dbReference type="GeneID" id="110984861"/>
    <dbReference type="KEGG" id="aplc:110984861"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022101134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022101135.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="35804" checksum="CB0F1E62381ECDF7" modified="2022-01-19" version="1">MGLTDHELTIDDVRRAEQRIKSYISRTPVMTSRRMDAKAGCKLFFKCELFQRTGSFKFRGALNFLSKLAEKSKDGSLPCVTTHSSGNFAQALALASSLLNFKAYVVMPSIAPLCKQDAVKEYGAELILCTPTEQGRIAAKDEVVKSTGAIYAPSSQHHDIMAGQGTMFLEMFEQVDKKLDAVIVPVAGGGMISGILIAAKTLQPEIKVIAAEPELADDLYQSMKAKRHIRLDHYPDTIADGLRVSVGDVAWPIVRDLVDDVITVTEDEIKESTKLVWQCMKLCIEPSAGVGVAAVMSDKFKAAFPDIKNVGIILCGGNIDLDSMKSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6B1</accession>
    <name>A0A8B7Z6B1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SEC13 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110984885</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101178.1">
        <property type="nucleotide sequence ID" value="XM_022245486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6B1"/>
    <dbReference type="GeneID" id="110984885"/>
    <dbReference type="KEGG" id="aplc:110984885"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="15">
        <location>
            <begin position="143"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022101178.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41169" checksum="EA7E8BD2108B40A6" modified="2022-01-19" version="1">MHPKEIERVFCTHFLKVNCTHTWHKTTDSRTCISGMSGKEFHILADNAVQKRDQVSVISTVDTAHEDMIHDAQMDYYGIRLATCSSDRSVKIFDVKGGQQTLVADLRGHEGPVWQVAWAHPMFGNILASCSYDRKVLIWKESNGVWDKLFEHSNHDSSVNSVQWAPQEFGLVLACASSDGSVSILSYTDGKWESQKIKDAHAIGCNAVSWAPAVEPGSLIEPPSTQKLVPVKRFVTGGCDNLVKIWKEENGEWREEHKLEAHSDWVRDVAWAPSIGLPHSTIASCSQDGRVIIWTSDESTGTAWTPKILNKFSDVVWHVSWSVTGNILAVSGGDNKVSLWKESLEGQWVCVSDVNKGEGQSSTPTDAQPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6L7</accession>
    <name>A0A8B7Z6L7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger MYND domain-containing protein 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110984580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100602.1">
        <property type="nucleotide sequence ID" value="XM_022244910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6L7"/>
    <dbReference type="GeneID" id="110984580"/>
    <dbReference type="KEGG" id="aplc:110984580"/>
    <dbReference type="OMA" id="VCSKPAY"/>
    <dbReference type="OrthoDB" id="3174329at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053248">
        <property type="entry name" value="Zinc_finger_MYND_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46533:SF1">
        <property type="entry name" value="ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022100602.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="44238" checksum="7E5091E09EE07462" modified="2022-01-19" version="1">MLIYGYKSLACFQLSSNMTLNPLANPKGVKLLCELCQKPAFVQCTKCRVTFYCGVEHQQADWVGIHEKICQLLIPLRTPQLSFLSSEEQRRKKEQDLLLRQRNMIDLTRTTGQKLLFEGKHEQAVPAAMQSLRFSIDVHGLDSIELVPSYLILAEASIGLHKLSQAEEYLAQAQWTVLKTPNCSSAIKSKLARNLGLLYAAQGNYDESLRHLADDIFHASEEFGTDDIRTSGGYFHMANVFFRQNRMDVADSLYTRVTSIWHSHLLRIVTDRTKKSDTQSGMSSAVVELEERKVESLDEAQEAEAKQVLHSIHDIREQVTNQDPAAMATIGHALAMLYFLLDDIPKATELGLKAQTSCNATHSEDGELAAAINEFNSTLNHLPLKPNLLQTDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z723</accession>
    <name>A0A8B7Z723_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Uncharacterized protein LOC110984673 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9" type="primary">LOC110984673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100762.1">
        <property type="nucleotide sequence ID" value="XM_022245070.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100763.1">
        <property type="nucleotide sequence ID" value="XM_022245071.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100764.1">
        <property type="nucleotide sequence ID" value="XM_022245072.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100765.1">
        <property type="nucleotide sequence ID" value="XM_022245073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z723"/>
    <dbReference type="GeneID" id="110984673"/>
    <dbReference type="KEGG" id="aplc:110984673"/>
    <dbReference type="OMA" id="QFINITH"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="178"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022100762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022100763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022100764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022100765.1"/>
        </source>
    </evidence>
    <sequence length="1099" mass="122963" checksum="9C00B895AF7012F2" modified="2022-01-19" version="1">MQSAMSEVNLRYLASNLGKEWRKLASYLQVRKDEIDRIQADHQATEEQIFQMLILWWQRQDHSRRGTDDGALNALCTALRESGRPDLISNFRAGSTSHDEDWNVDLCRAELIRFYGETMGKVPLLPWVSSDVSRIVDIFGEIQLMESRNKTSRVVQRKLSSYAEMLMLTEFGEDQPVTHILLYGVAGCGKTTLVSMIAYDWALQKPGSPLAKFRLLFTINLRDLIKGTPTLMDAVYDQLLPEDTMVCQHSLRGYLHARSKEVLVIMDGFDETGFGGSQISGDLVKIIGGKILQGCTVIVTTRPYMVEPLNRLNPNFTRIESKGFSDDAVQLYIQRFFQDEDDSQVSVGLCRVINEYDNLLDIVRLPIMLLITCLIWSEDRSLPRNITEAFREAAFFILRRHFKKSRKLDSLDDEFIDSELKELIKDLGKAALDGLMLPGEKLVFEPTDFGNTKAVDKACQIGILSQERTRSKLRAVQNVTFIHKTFQEAIAGFYLAQLAETDHAFFSRHYLKRICKDNVHSLKDVLRFSSGASVNAAKILLAHVVSNDVVQRNEETFALFLLMLLESRCSELHSTAAPLLAKDGLYFTFTCSVYQKSAFEFFVECASQSPIGDQCGKQSVFMDLKRLVLLDVTREDAALVNSIFKCALSVSEVVLGLAAVGKLAESESVLRPEDYLCETLCHMPLLENLCLFPSEGQGVCLSRQLDLSVIVGRLATADISSLRVFVLQSVSAGPRQIQEVSRRRANPSKSLTLLGGVSHKARPLSCRDATHGQDTERKPPRLLLELEAGFHRVESISGRDHSVPGLRSIQLLHNDRQADLQPVSSLLSRATNLEVVDLSRLEIGTFFSVVSEPLSKLGKLKELLLSETGLSSDDVMLLTQKVLPFMANLEILSLSHNNVARQEALLAVVRWACSSTCLTELFLGGCVGMLSASDELSTACVRDTVDAKDDPELQPFERTEVLQQRSVEVVDVQTNYLHRYTPDLIGLLKHFIALRTINMSSMGLTDSDIVELAGVVTACTQLEMLHLEGNEDVGNTGVEALLRLLPQLPNIRHLCLPFDDTSERYSDIVSRCLKRRSMILGCYTLSQEEIQTAIQIVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z745</accession>
    <name>A0A8B7Z745_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">33 kDa inner dynein arm light chain, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110985055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the inner dynein arm light chain family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101463.1">
        <property type="nucleotide sequence ID" value="XM_022245771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z745"/>
    <dbReference type="GeneID" id="110985055"/>
    <dbReference type="KEGG" id="aplc:110985055"/>
    <dbReference type="CTD" id="7802"/>
    <dbReference type="OMA" id="QVTIICA"/>
    <dbReference type="OrthoDB" id="273640at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183:SF0">
        <property type="entry name" value="AXONEMAL DYNEIN LIGHT INTERMEDIATE POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="AXONEMAL INNER ARM DYNEIN LIGHT CHAIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="180"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022101463.1"/>
        </source>
    </evidence>
    <sequence length="259" mass="29669" checksum="822379ABBF736EB2" modified="2022-01-19" version="1">MIPPNASLVRYDTPVLVSRNTDKKTPRARALRTSPQPPTNAGPVPNPPPKGGSKLPPVEAQKAQQTDEILNSILPPREWTDNGQLWVQQVSSTPATRLDVVNLQEQLDTRLQQRQARETGICPVRRELYSQCFDELIRQVTIECAERGLLLLRVRDEIRMTIAAYQTLYESSVAFGMRKALQAEQGKSDMEKKIVELEQDKRELERQVNELKAKCDAIEKREAERRQVEEKKHTEEIQFLKRTNQQLKTQLEGIIAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7G0</accession>
    <name>A0A8B7Z7G0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110983897</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022099241.1">
        <property type="nucleotide sequence ID" value="XM_022243549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7G0"/>
    <dbReference type="GeneID" id="110983897"/>
    <dbReference type="KEGG" id="aplc:110983897"/>
    <dbReference type="OMA" id="PYSMQLM"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12336">
        <property type="entry name" value="RRM_RBM7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052285">
        <property type="entry name" value="NEXT_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798">
        <property type="entry name" value="RNA BINDING MOTIF RBM PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13798:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022099241.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33304" checksum="10CC55B5C3C3BCB1" modified="2022-01-19" version="1">MGDGSSRDDRTVYVKNLDIRVTEEILFELFLQAGPLIGVKRPKEPDGTVKSFAFVEFEHDVSPPYARSLMDGIRLFGRSIGVQFRNGSKHSENSRGNSPAGTPPYMNSSGHQSPALNGLPSFPLPPMIQRSVSAPQGFPGLGSGLPAMGMPPPLMGNFPVHGFFPAGVEPRPVHMPLMQLQQQQLDGPSDRQPPQHHFQDRQDGVRHHQNHRHHPSSSPNPHHRSSHQSPTEEQRSRSHRREGHHHGHSSGSDQDNRYHSNRGQHSEERRHGSEQRHRSHQHHRQERRDHPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z830</accession>
    <name>A0A8B7Z830_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein unc-104</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110985244</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101819.1">
        <property type="nucleotide sequence ID" value="XM_022246127.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985244"/>
    <dbReference type="KEGG" id="aplc:110985244"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000023">
        <property type="entry name" value="Kinesin family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000001">
        <property type="entry name" value="Kinesin family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000247">
        <property type="entry name" value="Kinesin family member 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000253">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF10">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="3"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="14">
        <location>
            <begin position="501"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1584"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1423"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1462"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1434"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1492"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="96"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022101819.1"/>
        </source>
    </evidence>
    <sequence length="1699" mass="191648" checksum="83DF9393DE3C37CE" modified="2022-01-19" version="1">MSSVKVAVRVRPFNSREISRSAECVISMSGKTTTISNPKAQNKEQPKSFTFDHSYWSHTTPDDPNYASQRQVYDDLGQEMLTHAFEGYNVCIFAYGQTGSGKSYTMMGKQEASQEGIIPLLCKELFDRVSSHPEANTQYSVEVSYMEIYCERVRDLLNPKNNKNLRVREHPLLGPYVEDLSKLAVMSFNDISDLMDEGNKARTVASTNMNETSSRSHAVFTIVFTQKRHDLETDLFTEKVSKLSLVDLAGSERADSTGAKGVRLKEGANINKSLTTLGKVISALAEVSQMQASQASKKKKKADFIPYRDSVLTWLLRENLGGNSKTAMIAALSPADINYDETLSTLRYADRAKNIVCKAVVNEDPNAKLIRELKEEVQRLRELLIAEGIHIDSLHSGSTEGSGQQQRIIPVQPMKEDALDRLKESEKLIAELNETWEEKLKKTEAIRLQREEMLAEMGVAIREDGNTVGVFSPKKTPHLVNLNEDPFMSECLIYYIKEGITRVGRSDANITQDIQLKGSHIQEEHCLFTNEDSQVKIVPFEGSMCYVNGKKVSNPLLLRSGCRVILGKYHVFRYNHPELARQEREKTPQVEATSAGEKEPVDWAFAQNELLQKQGIDIKDEMERRLLAMELQYKKEKEEADQLLEQQRLDYESKLQALQRQVEEQSLLSGNTTPGDLSGEDDDNLESHQWTPREYALASWVVRKWRYYRFTSIRDDLWGNAIFLKEANAISVELKKKVEFQFVLLTDTIYSPLSPDLLSSADNADILERPFPRTVVAVEVTDKKNGAVHYWSLEKLRKRLELMREMYDNAADATPTTPESLGFENSAVTCRDPFYDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVNEKGDVQGYLRIAVQHVAPDEEAPDYGSGVRQSGTAKIAFDDDEYFQRKFKRSPTNLSQSVISEDEVRIVEGQRENSDLDIIEKQDIEAMSTTESMTSISTSLDVPENDSLKLGLTFTFRVTVLQASGISSEYSDIFCQFNLLHGREAFVTQPVQNKVQGGGAPLGFYFVQNISVTVTKAFLDYVRTSPIVFEVFGHYQAHPLHHQSQETTRLRPLKRNFPASLPLARPVPSPKLGLVSTPSTSHLHSRHDLLVFFEICELAPSGEYLPAVVDHSDELPCSGVYLLHQGIQRRMAITVIHESTNELLWRDVRELVVGRIRTTLEVTEPDHELSVLSLNLLPAMYIQQPGDDRTCFRFEAAWDSSLHNSVLLNRVTPYGERVYLTLSAYLEVSRHMLDNCTQSACITKDICLQMYERDARISPARSLRTLFGSSYYKASDSRVTGVYELSLRRSAEALSPAGLSFSQYDLRDLLESTSPGANTPQTSGTQRRLRRVIDTSGTYVRGEENLQGWRPRADSLLLDHQWELEKLSRLEEVEKARHNLLLRDKIQQELVNTRGDGLPKSETDTSLDSTLSNDSTDRDYELLDRCVKLMMRNQPPVLSPPPFKTSEPPTVTLQTPDDRNEANASTAAATGTAGVTSSQGQEVTTPDEPMPSSSSMQDLQLLGPGTRKLQVPTDLPGIQGQEAAAATAGDAGKLKKGSKGMFVPEVEEIRVSPVVSRRGYLNFLEEKTAGWVMRYVVVRRPYVFIYDSDKDPIERSLINLATAQIEYSEDQQAMLRTPNTFSVITKYRGFLLQTIGDKDVFDWLYAFNPLLAGSIRSKLSRRLATQLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z867</accession>
    <name>A0A8B7Z867_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cilia- and flagella-associated protein 74-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110985259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101858.1">
        <property type="nucleotide sequence ID" value="XM_022246166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985259"/>
    <dbReference type="KEGG" id="aplc:110985259"/>
    <dbReference type="OMA" id="ENTMWHI"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056306">
        <property type="entry name" value="Ig-CFAP74_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056307">
        <property type="entry name" value="Ig-CFAP74_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056310">
        <property type="entry name" value="Ig-CFAP74_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF012200">
        <property type="entry name" value="choice_anch_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22538:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24770">
        <property type="entry name" value="Ig-CFAP74_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24778">
        <property type="entry name" value="Ig-CFAP74_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24798">
        <property type="entry name" value="Ig-CFAP74_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24771">
        <property type="entry name" value="Ig_CFAP74_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP74 second Ig-like" evidence="3">
        <location>
            <begin position="664"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP74 third Ig-like" evidence="4">
        <location>
            <begin position="869"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP74 fourth Ig-like" evidence="5">
        <location>
            <begin position="987"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1216"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1223"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022101858.1"/>
        </source>
    </evidence>
    <sequence length="1713" mass="190064" checksum="3109E4C9CF400A01" modified="2022-01-19" version="1">MSGGLTVPHQDGDTYLLDDSPSPDGDDLQSSFGGGASGGGPETRQWMESSEGPLEYESDPEMWSQSDDTSLTGPEESLSEQGSDRPSFAKQKFSRHEKLRMLALRRHLDNLAGQVLESEHIVQTTREELKKCRTKLEALELEKEHTTEQLQQSEEQGNMANVHRLKSKLAKLEKELEAEGDLEKQIQERLDQAELDLSKAELEQGKFILAEEDLEVQEERLEQERMENTMQRARKENIKVVQADRRRKNRERDHMAALRERDRKHRQAMSAARRSREAAAKYLKETVAKVRQKEADEEERHRTHMDQRVRTLLNLRSDVSSNRENLRALQARSHYVAQQEREALDREREDLEVAGENAEEVMLRKQRLQQFEQEKQQHEANQKERQAELLSHLLREERQMKKRQAMYPQLWPDAKRDRAKRVTRPKRKARIIREYSGSSSMEYSADVEEAAVPKPSSAKLAGADISSDDDGFSPYGATSRDERGGSDSEDRKDELAKPEFEGLWNQQHKTYKVPKEEDAGYSLKYTSKMERDMMAAALDKHRAGIVRKQVAAGKEFKGCPFYSKPDVIHFKDFDVGKSYKKKVILTNVSYSVNFIKLVDLSDHLKDFIDLQFDPPGQMSAGMSCEMLVTFKPMINEDLEGEVQFLTQTGPFCVPVNCSTKKCDLSVDTDGIDFGTQVIGETLKKTITLTNKGAKGTQFEFIKITGMKQNTVTSAGTSLGRLTTADITTRPNTSKDQDNIPTDEKEKADEPEAKNEGDTAPDTELAAGEETREPLSARSKKSGVVTITVDDTEGFTLAPDDLEDPSVWDGMRVGQVTGNEIGPFSSVKLEIIFNPTIPGAVDVDFEIRFTDPLSETISVKSVAVAIDVPVWVERQNVDLKICMFDRLYQDAIVVNNRATTALRIKFEVCKELRNHMELLPKTAYIQAQSQFSAQLKFLPRHSLIEEAGPCFDKETGVLEAPMTIRVADQTAPVLYTVHAVVTTSDMTFNTDFIDFGYATIHESVIATVKLTNKSILSQKFGFVNLPDYVDVQPNDGFGTLLPLEAIDLDIIFSAKKAKNYSFELTCKSGINRDFKISCKAVGVHPPLELSHSTIHFAATAMEDSSVTSLWVVNSHTSANEFTHPVPRIGKGEIAPVGPTAFEFVVPRGVPLAVSPAVGVVKPGKKTKISVKFCPQLGTADIKEEAVRLVTKAMETKAKYEFEQAQLAAKKSALEGLAEEEDAKKGKKGPKRNVKSPSGKSKASPTLQPVIPPKVEDIELGSDEYAAGRTSLLRQFAGRFSSYSIPCYVASGQPGDPGTLPYNVHNTLYLEVHCPAVKPPLVVISDRGRTTKDFGDISVGQRIIMSVTIQNISDQPLELKSSILDTSGPFSLLNALRSLPVDGTHTLLIAFAPLKAKVYQEVLDICCAAATLSICLKGQGISPVVNISLKEPKLDLGYVLAGEETSETFKLENVSPLAVDYVIKLASLSFRKHADQQGLPLFIRRDAAADAGVVGKANLSGSSVFDCVPCEGTLQPGSKTEISVFFRPDHPSECFSDVAQVVLYGKQEAHTIHLTGAAKSKIMYLLGGDQMQPPVESLAVVPVTDEEEDPKALPPAIPTLLSFRALSKEDETVPASRQLQVGCIRTMAISQKKNGEFFFDNLNMVTPKGFAVDTQRGMVEAGMTRAVNITWTPPKGHDPNMVIEASIIFNLKGDVLERYNLILRAQVVTEEMPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9K6</accession>
    <name>A0A8B7Z9K6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin AQPAe.a-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110985065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101485.1">
        <property type="nucleotide sequence ID" value="XM_022245793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9K6"/>
    <dbReference type="GeneID" id="110985065"/>
    <dbReference type="KEGG" id="aplc:110985065"/>
    <dbReference type="OMA" id="WIRTKAW"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022101485.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="33133" checksum="FBE7A5E257F6078B" modified="2022-01-19" version="1">MAQNSHDLRNHKSSRNSGTSSSRKKSKRERGWGIGLHCSAEFCRGVVAECLGTFFFMIVACTADLQWDSSVRVDVLRLSFTLGLAVMTMVHCFEHISGAHLNPAVTASLMIIRQTGIVKGLFFIAAQFLGASTAVLLLKGFLPISILGNMGYTVVSPQITTHQAMGLEFLMTFLFVFTVVSSTEATRFASKLVALPIGVAFLVNTLWGYEFTGASMNPARTISAAVVQGITDNWPVILEVYLAGPVAGGVVAALIYKFIFDPSFVPGSMRSLRSNSNFDSEEDSMIAMQSMSPHRKEERGTRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAR1</accession>
    <name>A0A8B7ZAR1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutaminase</fullName>
            <ecNumber evidence="3">3.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">L-glutamine amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110985761</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022102743.1">
        <property type="nucleotide sequence ID" value="XM_022247051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAR1"/>
    <dbReference type="GeneID" id="110985761"/>
    <dbReference type="KEGG" id="aplc:110985761"/>
    <dbReference type="OMA" id="FACPLSG"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:L-glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000069">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.710.10:FF:000008">
        <property type="entry name" value="Glutaminase, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00313">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015868">
        <property type="entry name" value="Glutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041541">
        <property type="entry name" value="Glutaminase_EF-hand"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03814">
        <property type="entry name" value="Gln_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12544:SF29">
        <property type="entry name" value="GLUTAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17959">
        <property type="entry name" value="EF-hand_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04960">
        <property type="entry name" value="Glutaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Glutaminase EF-hand" evidence="11">
        <location>
            <begin position="108"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="9">
        <location>
            <begin position="557"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00077251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022102743.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="69673" checksum="FAF5F2C62189F0BE" modified="2022-01-19" version="1">MARFTSRWAAVFNCCLPVNCRNFHGIPSRHVLSGSHSVLQRAALSPYPRLETRCLLVEPWLSCLQSTRWTHTTHFSRQHCKDDDEGKKTEDTVPESNGDGHDGLISLEDLVFHILSNEEKKVALRDFFAVLASKGLRQTDPRLQESLQKIQDKFTQQYPDNLSDTILERKDFQECISSNIVLIGRALRNMFILPDFPHFTAQVDRLYEEIKMNTSGELATYIPQLARQNPNHWGVALCTIDGQRHSVGNTTVPFSLQSCSKAPIYAEVLTRHGANYVHHFVGHEPSGRPFNDLCLNDLNKPHNPMNNSGAVLVLSLLSQSRNMADRFDDIMQRFKEMAGGEFVGFSNATFLSEKESGNRNYALCYLLQEYGCFPEGVNPMETLDLYFQVCSLEVTCESGSVIAATLANGGICPMTGETVFDPAAVRDTLTVMSSCGMYDYSGQFAFKVGMPAKSGVAGGIMVVVPNVMGFMLFSPLLDRFGNSVRGADFCEKLVSMYNFHNYDNLLHATKKQDPRKQRIESKASRVVKLLFAAYNGDVSVLRQYLLQGADMEQRDYDDRSALHVGAAQGHVEVVRFLLEKCKVDPNMKDRWDRTPVDDAEKFGHTEIAALLRAAASSRQLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFH5</accession>
    <name>A0A8B7ZFH5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450 4F22-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986663</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104408.1">
        <property type="nucleotide sequence ID" value="XM_022248716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFH5"/>
    <dbReference type="GeneID" id="110986663"/>
    <dbReference type="KEGG" id="aplc:110986663"/>
    <dbReference type="OMA" id="AWARIRC"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022104408.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43562" checksum="C9FA2AF4092E98AF" modified="2022-01-19" version="1">MAFSESEVNLCATVATLCITSSIVALVVLFIQKWKLERQFAAFPTDPERHWFLGSLSKFTADEKELEWKREVVKRCVTASVLWVGPIRPIISVYHPDTVKAVLSTGEPKAEFTYSYIRPWIGDGLLLSAGKKWARNRRLLTPGFHFDILKPYVDIFQQSGSILVEKWKAACGGKKTSMEMFSNMSLLTLDSLLRCIFSVETNCQTVENHPYIKGIYDISILAMERFRFLPFHFDTIFQWSPSGRRFHKACNTVHNYSRDIIQKRKNALKEEAAKGQTRHRKYIDFLDILLCAKAVKKRRFDWDPSPMMTTLQSVSEAFTFLARKIDNATKAPNPNPLPAVSPTSQGTFSDAKVVSVVLPDPFPQRDPAPDHVSDHGGSVPCHCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFL0</accession>
    <name>A0A8B7ZFL0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450 4F4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104404.1">
        <property type="nucleotide sequence ID" value="XM_022248712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFL0"/>
    <dbReference type="GeneID" id="110986660"/>
    <dbReference type="KEGG" id="aplc:110986660"/>
    <dbReference type="OMA" id="VPYLTKC"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022104404.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="43259" checksum="ADC055137BDFCC4D" modified="2022-01-19" version="1">MFEGHDTTASGLSWFLYDMAQLPEFQQKCQEEIDDLLAHREDDRLKWDDLGNVPYLTKCLKESLRVHSPVPNIMRTLTQPLTFPDGRTLPKGSSVAVVIGELHNNPHVWDDPETFDPERFSPERAKNIPHFAYVPFSAGPRVENHPYIEGIYDISILAMQHIRYLPFHIDTIFQWSPSGRRFRKACDTVHNYSRDIIQKRKNALKEEAAKGQTRHRKYIDFLDILLCAKDSEGQGLTDQEIYDEVDTFMFEGHDTTTSGLSWFLYDMARLPEFQQKCQEEIDDLLADKEDDRVEWDDLSNVPYLTKCLKETLRVHSPVPNIVRTLTRPLTFPNGRTLPKGECEQYPQFVPFLQACPCCAGVAYIVWTSVQKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGB7</accession>
    <name>A0A8B7ZGB7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD repeat-containing protein 82-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110986467</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104037.1">
        <property type="nucleotide sequence ID" value="XM_022248345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGB7"/>
    <dbReference type="GeneID" id="110986467"/>
    <dbReference type="KEGG" id="aplc:110986467"/>
    <dbReference type="CTD" id="80335"/>
    <dbReference type="OMA" id="KICVLNG"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032785">
        <property type="term" value="P:negative regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071027">
        <property type="term" value="P:nuclear RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000065">
        <property type="entry name" value="WD repeat-containing protein 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="247"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022104037.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="35659" checksum="E9AE04FE4E3AB2D5" modified="2022-01-19" version="1">MKLSDSVMRSFRVAKLYKDQNTERINSIDFSHNGETMISSSEDDSIVIYDCLEGKPKKTLYSKKYGVDMIRFTHAVNTVIYTSNKMDDNIRYLSLHDNKYIRYFSGHTKKVVSLSMSPIDDSFLSGSLDKTVRLWDLRSPNCQGLMHLQGRPVASFDPEGLIFACGVNSELIKLYDLRSFDKGPFTTFRLQQDRDCDWTQLKFSADGKLILISTNGAVIRLVDAFSGQPKQTFMGHLNQKGLLLESSFSPDAKYVLSGSQDGKVHVWNAENGTKTAVLESKHCESPMHCVQFNPKFMMLATAAQHMAFWLPSIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZH24</accession>
    <name>A0A8B7ZH24_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110986542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104175.1">
        <property type="nucleotide sequence ID" value="XM_022248483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZH24"/>
    <dbReference type="GeneID" id="110986542"/>
    <dbReference type="KEGG" id="aplc:110986542"/>
    <dbReference type="OMA" id="CLESEIW"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022104175.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38113" checksum="7187CCA16133BF0D" modified="2022-01-19" version="1">MFCPGVVVFLIGSVPAIWLLELEIYELRSTSKRTTEEGVMVDDVNKVYGVIIEWILITEQMLPLLLIVGRWLLPKGAITRDELSQLLLVYFATASDIIEFFDGFKEPAIRYNRQLVVTLLTLWSWSLLQFSLVTTATRSSVTKPTGQSESTSTTTTQARRKGLLQRAVFKRFPRLAASRAVAPVCPANPLLRDPVEGLIIPVKPEHEVREDATPACTCLESDVWSVVASIILQDGPFLVFRLTLITHFRAYSHTNIFFTCKNLIVVALQAYRVLVLYAERREKQRRDRKRKEKLAKRLAELKKQGYSFPPELEADIVVADDTSDLDPYVAAMLRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHC1</accession>
    <name>A0A8B7ZHC1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985729</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102651.1">
        <property type="nucleotide sequence ID" value="XM_022246959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHC1"/>
    <dbReference type="GeneID" id="110985729"/>
    <dbReference type="KEGG" id="aplc:110985729"/>
    <dbReference type="OMA" id="HIAIPTC"/>
    <dbReference type="OrthoDB" id="6103344at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002072">
        <property type="entry name" value="Nerve_growth_factor-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00243">
        <property type="entry name" value="NGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00140">
        <property type="entry name" value="NGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50270">
        <property type="entry name" value="NGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nerve growth factor-related" evidence="1">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102651.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="26052" checksum="139473C17DA871E2" modified="2022-01-19" version="1">MCMRAVSPLIPLSLMGDFKTGAQTKGVSAVVFLLIAVILGKTGVEARVAQQKSEPFFDILDVPPELRSIPEKPTLYDILSIPSMEEAAVMRISFAPDRPSHIPDVPNGGTAWSGDSTEFVPEPPLSMFKRDRGPPFRACPVKNEWVHIQTATDIYNEEVEVSQLQWFWHTTCRHENQSCYGFSPSEEGATTECRETNSWVMAWARELEETDYSWRHIAIPTCCTCAVIQPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIL5</accession>
    <name>A0A8B7ZIL5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein fem-1 homolog B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110986811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104720.1">
        <property type="nucleotide sequence ID" value="XM_022249028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIL5"/>
    <dbReference type="GeneID" id="110986811"/>
    <dbReference type="KEGG" id="aplc:110986811"/>
    <dbReference type="OMA" id="ISTKTTC"/>
    <dbReference type="OrthoDB" id="4429489at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="504"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022104720.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="72043" checksum="7C30CD0E22F18061" modified="2022-01-19" version="1">MTIYSPIPPPLQEPQLQNLSTLSWRVFQAAKNGKPITLGALLYDKSPAIINLVLSESVECDDYRCTALVAAARNGHNTVVKLLLDQYGVNTEQTGTVKFNGYVIEGATALWSAAGAGYFEVVKTLVDHSADVNHATVSDSTPLRAACYDGRLDVVKCLVQNKADIHKPNKYGNTCVMIAGYKGHGAVVEYLLVNGGDVNAQANCGATAMHFTAECGRLAIVKLLVRHHAKMLKNEHGLTPLMVACDNGMAEVAEFLMSLPKVTTMEKIQALELLGASFANDKEHYDIAKTYHYFYLAMLHRCMESEKVNIKEVCELSPAYADRRECVTLQELKEIKGDHFALQMEALIIRERILGQQNPDLLHPIIFRGAVCADSMQFSSCISLWMHAMNIRHRLNRSIQKDILRFAQVFSQMLHIGEEVPFQNLYHVLALAVVEIESWQAKLKSAQDQVDRKSLQSVLDADILTTLYILMVMINKHVNKTKTQEHQSKKLVYRLISLNPRTANGSTPLHMAVNQLTPVDDFHTNNVCYFPSYRLVELLLECGADPNATDHFGETPLHVVVQYNKPISDFTTLHSIIVLLASRGCHLDQTNDEGKTASDVSTTGVAEIILIALIKPSLKCIAARTVKRHGIKYKGLVPKTLEGFIEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJ18</accession>
    <name>A0A8B7ZJ18_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Growth/differentiation factor 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110987262</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105534.1">
        <property type="nucleotide sequence ID" value="XM_022249842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJ18"/>
    <dbReference type="GeneID" id="110987262"/>
    <dbReference type="KEGG" id="aplc:110987262"/>
    <dbReference type="OMA" id="RMDGDFL"/>
    <dbReference type="OrthoDB" id="6516235at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13752">
        <property type="entry name" value="TGF_beta_INHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF298">
        <property type="entry name" value="DAWDLE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0339">Growth factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="TGF-beta family profile" evidence="8">
        <location>
            <begin position="437"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022105534.1"/>
        </source>
    </evidence>
    <sequence length="553" mass="62137" checksum="AFC7623CA9757045" modified="2022-01-19" version="1">MAGFSRASLYSRLVVAASVACLASFYCSLVGSAMVPANAQTLMGGQRGDGDPSPPLAHVDSHTPHRKGLKHPQWESDSKFSSSKIAIDNNHPTMQHFTKTKDAEVSDYNQRINMDGSSTRENRILLDDSLMVREEEQPIRSRVARAAAESVPVASSKFLEKTVESFNNFEGSGSDQPSQDDVQKGMVEEPSAETRLGVDNADCPECLRRKQEMKKLPPEKLRQMRLEQIKKRILSKLKMDQAPNISASSVDIPEPLARGRMVENNNDVSGMVDQEDSYLEDDRWEEEELNEIEENYQDTSQVIVTAQEGLGACPHKTSSSGCFSFEITSNVEENIVSAKLWFLLNDSPMEVDQNRTLVVSHIGTGRHSRRTSLHTVTVVYRADWVTVDVTRAVRHLVVHAKKNYLFEVRCTTCLNTGNPTNMKSGRRPFLVLGKTERRPRLPRSIICPPNHTTCCKEIFYVSFAELKWDWIIEPKGYSANYCRGSCEDNVAQGYGHTYIMTTVKNMNVDRGLSIIPCCAPIKTKPLVLLYYDNEGFIYKKQLQNMITESCACM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJD8</accession>
    <name>A0A8B7ZJD8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Poly(A)-specific ribonuclease PNLDC1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105132.1">
        <property type="nucleotide sequence ID" value="XM_022249440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJD8"/>
    <dbReference type="GeneID" id="110987039"/>
    <dbReference type="KEGG" id="aplc:110987039"/>
    <dbReference type="CTD" id="154197"/>
    <dbReference type="OMA" id="SCDRASC"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990431">
        <property type="term" value="P:priRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990432">
        <property type="term" value="P:siRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051181">
        <property type="entry name" value="CAF1_poly(A)_ribonucleases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092">
        <property type="entry name" value="POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15092:SF22">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE PNLDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022105132.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="65578" checksum="4C25F0A204F9722C" modified="2022-01-19" version="1">MHSHVPAQRGLFEVNIFELALYLSCSCRLRPCTVYSSRDMANITRHNFEELLPGILSTIEKCDFIALDTEFTGLHFHSDSHNSLFDTPQERYSKLRQTASHFTLCQLGLSAFIKAPSENRYCAHTYNFYLFPRSCSTVDARFYCQASSIQFLCQYGFDFNKLFYEGVSYLSMEAEKELRQQCQGQESILTSDVDDYLVTNFTSAISDWLPTAKEGDQLSMTKISDDIVSVQVQALLRDCFPTIWTSQVGTGEILITKVTPEKRAALLADETPWIERLFVKLAGFNKVFRHISELKKPVIGHNFLTDLLFLHSKFYKPLPAKFKDFKRNIHKLFPHLYDTKFLIMEIRKNLEEEGLPLASTSLSRVYRALHTDPRKLGVPHMPDIELAENCARYDQEELFHEAGFDAYLAGYVFLKMAHYIKAKDTSIMHPKLLTFRKYIPALAPYENKTNVIRGSIPYVNIAGEDPASRRPKLLYVTSRGPSPLQAKELATLFNTYTSVDVKMIDKRHALLATSNYGGSKDIMRAFKNDKTIHLAYYNVFQHSKPVRYGLWGAVAVMGAISLWVLLGDQSKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJI7</accession>
    <name>A0A8B7ZJI7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrosomal protein of 112 kDa-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103456.1">
        <property type="nucleotide sequence ID" value="XM_022247764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJI7"/>
    <dbReference type="GeneID" id="110986121"/>
    <dbReference type="KEGG" id="aplc:110986121"/>
    <dbReference type="CTD" id="201134"/>
    <dbReference type="OMA" id="RMHEKEX"/>
    <dbReference type="OrthoDB" id="78101at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055310">
        <property type="entry name" value="CEP112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027831">
        <property type="entry name" value="DUF4485"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18871">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 112 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18871:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 112 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14846">
        <property type="entry name" value="DUF4485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4485" evidence="2">
        <location>
            <begin position="57"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="420"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="622"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="691"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="895"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022103456.1"/>
        </source>
    </evidence>
    <sequence length="937" mass="109812" checksum="9C0D212558AADD51" modified="2022-01-19" version="1">MHVQLSSGGYQSNYNIHHISTQGTNEPRPAALKSLLREDINVSAGKMETSLSTSEELDDEFDRSLVKMKPHVLRLSPKSERQRCANWIKKLCEPPGSGPTARKNRNLYANLLLHMLQKGLIEGPFAHRPQPGPLPTLPAHMSIYFDEPRHASFPAHSESGAVSLHVPDWVYSELSQNGSSSSTQPTATSTLREKYHSTTGSWLHQRARSENEVVSANAGGDEDYHKTQSNVHQEMFSYDASGTMGPGSPSKTSFQANSTLREGTIPRRQHEKELEMRTKMMEAKHHEEKLQLQQRHDGAIQKILDRKNSEMEDMKSHYRSKSKEMETTVRKLERKVQSLVKESVIIRDSKDQQIAELKKMVEHSDQSTQNEFETKLHEKTTEFEQEKFEMQKHHTRAIQEILDDTNARLHKMETEYSEQVDHHATVIRDLEERITQLTQESENQNAAQAELDREKADLERTNRLVNAELENIRTSQSAETIRELEQHVQDLKQQLQESEHRRQRELRDLESMLKQDKLHQENLHEKQILSLRSELEGERQDNHNKILKVQQAIRDKDDQLEKSAELRKMQTQQAEKALEEFKLQVEQNSSRMFEDMKAQMQKVEADLLQSKDLRQTQAKEYARQLDQERKRFEKQFSEQEALHNEKLSQLVQQHQMEQESMQQEHERILAGSTGRLQSRIDEERNQSVQRQDQDATVIRELEQQVRELRQANMQNDSLRKQQLVELGLLREEEKQKAHRESETAVSKLKSEMEQQRLRLQRDHSAEMEQMLQETNARLKNIETDYTERLAKTAENNKQLTERIETLQQEFLSSRNELERQMSDAITKLEDEKELLKKQHSAYLKTLHQDLDKQRTRARQVERELQQKDFQHQDRMTHLKQEYEHRMRGLMPLNVRQELEDTIESLKAQVSALQQRSMLLQEDIDKSRKATVRSPSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJM1</accession>
    <name>A0A8B7ZJM1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110986150 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110986150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022103491.1">
        <property type="nucleotide sequence ID" value="XM_022247799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJM1"/>
    <dbReference type="GeneID" id="110986150"/>
    <dbReference type="KEGG" id="aplc:110986150"/>
    <dbReference type="OrthoDB" id="5975103at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027805">
        <property type="entry name" value="Transposase_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080:SF133">
        <property type="entry name" value="SI:CH211-262I1.5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23080">
        <property type="entry name" value="THAP DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13613">
        <property type="entry name" value="HTH_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase Helix-turn-helix" evidence="5">
        <location>
            <begin position="605"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="DDE Tnp4" evidence="4">
        <location>
            <begin position="689"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103491.1"/>
        </source>
    </evidence>
    <sequence length="848" mass="94946" checksum="264DFBD7848BB4C7" modified="2022-01-19" version="1">MSVGTRKEDSPSVSRFLSRSKKEIRGLGLKPVNSGTQRSTRHAACIMREFCKETGRGQVPFETLPLAELDSLLEDFFGNIIKRDGTPYNRNGLIGIRYGLARFLKEKRHFDITAHPGFSKSIHAYKARQAELKRKGLDVVNHYPPFTVPDLIKLYSSFDLANPTSLRQKVQFDVMFFLCRRGRDKLREMTKDQFVLDTTPAGQRYVRPSGNQPFNQESVEYAGCTNVMLERRESPLCPVLSFEVYMSKLNPLSNWLWQRERAANEMTGPVWYTHAPVGKNSLATLIPVLSQELGLSMSYTNHSIRVTPLTTYDSALPKVSFVKASQQAVKIPVTPVNICLRNVPSVEPSLDTPARSKQHQECYGTAEQGANPPIGTQEHHQTLSVKTPDEAPGPYRQIASQTATASTDAVCESTPNHLINDNQTTYPCLPATFHVSHSTDTDSSKIYSGHFRPGEVKGSFGGRWRLVRDTIPSVFFFSKADRPSTSSSKDRCKDMTGSEKECAGSGDSQSQTAHHPAHGCVPTSTNDHLQAAVLHIQQLEVQNRQLQNLRFEVGRFCDDPDLIQFYTGFDTYNQFCDAFQALQPTDELMRDGSWSAIRDTTRNENLTPTDQFFLFLCRCRAGLLEQDLAVRFGISIAAVVGILTIWTNYLHFRLAPLLVWPSRECVNVHMPQCIKDICPRLRVILVSTEMKYRASSLYINNRECSQQKTASTFKGLVGMTPTGAVSYLSPLYMSNASEEEIVIQSGLLDKLDADDDIILNGRVLSVECPHFTDSKTSDSPPVLVNQEPSLFDTAGLDVAKLQSHLERVVSKVTAYRIFESPIPTSLVESLSKIWTICCLLTNFKEPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKM1</accession>
    <name>A0A8B7ZKM1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Inhibin beta C chain-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12 13 14" type="primary">LOC110987212</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105433.1">
        <property type="nucleotide sequence ID" value="XM_022249741.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105434.1">
        <property type="nucleotide sequence ID" value="XM_022249742.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105435.1">
        <property type="nucleotide sequence ID" value="XM_022249743.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105437.1">
        <property type="nucleotide sequence ID" value="XM_022249745.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105438.1">
        <property type="nucleotide sequence ID" value="XM_022249746.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105439.1">
        <property type="nucleotide sequence ID" value="XM_022249747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKM1"/>
    <dbReference type="GeneID" id="110987212"/>
    <dbReference type="KEGG" id="aplc:110987212"/>
    <dbReference type="OMA" id="PRERNDW"/>
    <dbReference type="OrthoDB" id="8863549at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08698">
        <property type="entry name" value="TGF_beta_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF309">
        <property type="entry name" value="INHIBIN BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665725" evidence="6">
        <location>
            <begin position="25"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="7">
        <location>
            <begin position="304"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022105433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022105434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022105435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022105438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022105439.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47491" checksum="B661CB68BE8D8818" modified="2022-01-19" version="1">MTVTMVVAPFTMLLLLITYNTSMGRCTAPSALPGDKNASAENNLSGSQPTLVEDEHSIIFTQGTFSPSNSPSPSSTDSPNPRPTENVIDGLSARERAFRIAMLRMQLQEKLGLTELSPASDKPYRTLPLAIKKRLMDHQPPQRDLPRYERPASQITEVLSYAENYTNDCPEPGFCFRFHLVRDIIGKTVKSVHLWLFLTSSEDFNRSPARRLTIWLLNAKDTGIKREELATKVMSKREGWFHLKLPREKNDWSSTEHRLQLTNAATDFFTDSSQEPLQFPPVSLARDELPVLAVAVDPDKHHQRLRRQSQCQGDSDTCCLQYFEVDLKQVMEATIYRPSTIFANFCRGSCLQVSNFATSHAYVMRNQALAETDDDLRRYLSPCCVPATYEPPVSILYRLTDGTFIQRLVSEISAQTCVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKT5</accession>
    <name>A0A8B7ZKT5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Adhesion G protein-coupled receptor A2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106238.1">
        <property type="nucleotide sequence ID" value="XM_022250546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKT5"/>
    <dbReference type="GeneID" id="110987643"/>
    <dbReference type="KEGG" id="aplc:110987643"/>
    <dbReference type="OMA" id="ISKHSEW"/>
    <dbReference type="OrthoDB" id="10037534at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053066">
        <property type="entry name" value="ADGR_G7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767:SF1">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="964"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="998"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1067"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1108"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1152"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1177"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="54"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="184"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="12">
        <location>
            <begin position="394"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="10">
        <location>
            <begin position="777"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="11">
        <location>
            <begin position="962"/>
            <end position="1201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106238.1"/>
        </source>
    </evidence>
    <sequence length="1274" mass="140138" checksum="AE66D2D810420F0A" modified="2022-01-19" version="1">MDTNVKPGRRLAIIVILTSSVAFCVFPVNASREAFPGMCSDGWLALGVNGSYNCYKFFNFSRWNDRLNWTNAEEACQLEGGHLVSVHSRQEQDFLNETISKHSEWYQWWLGLSDTDQEGTFVWSDGTETDVLFWHTRQPDGGRHENCVQMLTVYHQDEWNDRPCSQRMNYICKRAVCPNGWRNNGAMCYNFVAFGPLNWTLSEAACKREGAHLVSIHSQQEQNFIYLNLGQYSSGYEWWLGLNDIDEEGTYVWSDGTLTNVLFWDQHEPSGGIEDCVHMSRLLHQNTWNDRPCHQGMRYICKKAIDNEAPVIICPASLILETDPGQSFASVPLLDVISATDNFGIFSVTIEVDSVPLRNADAILSLKTSSYSIRYTVSDATYNSAMCETNIIVVDKTAPTFLVGCPSNINHFINTSLVSTPVSWPTLNASDPSQPLLWNSSHQPNDLFPVGNATLVTYTVTDQYGNYVSCNFTVTVTGVGLDCPENVTTVAQPGSTSTNVSLETPTIFFRGSRKDVLYSFADDNPLGNETGEGIVHVHSEYLARDVFHVGETSVSYCIQETGVQCQFYVSVIGRCASTTTADGLSWPETLEGFIAESIERCPVTTTNVGLPLAVRNCSVIEPPVYLQWGEPEPRDCGDAVSVHDIAKVNISGSNVAEVAKYLSNQSSATPFSAEGLYVISQVLMKIAETGSGDVEVTEAVLETVNNIILKADTSTVSNASSSTSSIVQSVQTQVSLTLQQEGHVSIRQDTVNVEAVSLDPEKASGGFSFVSVRRPGQVETPQDESLVGAEVETFFNTNEIPTDIDVVASVFLPGNIANSTKPTVGNTSQLQASFLIYADDTLFQSASIRKYREQNNSTRKVAGSVVSLTVENVELDNLIEPLVIKFRTPISSASAELDIKSTRCVSWDFGLEDGVGDWSTAGCTLAVSTSERISCHCSHATNFAILVNVKGQLWDASIRRTLDIISQVGCVLSIIALVITLTTYLSIRKLRNGKSRQIFIHFCFSLLMLYIVFLAGVDNAKGSGGGCVFVAALLHYLTLSTMMWMAVEARNMYISTVKVFPEDRPWYILKACVIAWGSPLIVLTITLATATNHYGAMHYCFLRPGLVLYIGLLTPIGLILIHNIVTFVLVMRSLLTVKEASGSQQISKRLQNAAGISVLLGLTWCFGFLAINEAVFAFQLIFCLANSFQGVAVFIMFCVRREEVRTGIAPYMKRLCCGRDCSMPELHPSRSYDVALVLSSASESSTSNTPGTKIDTSVSETQEGVAFFRYIQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMW6</accession>
    <name>A0A8B7ZMW6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Meiosis 1 arrest protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106402.1">
        <property type="nucleotide sequence ID" value="XM_022250710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMW6"/>
    <dbReference type="GeneID" id="110987716"/>
    <dbReference type="KEGG" id="aplc:110987716"/>
    <dbReference type="CTD" id="130951"/>
    <dbReference type="OMA" id="LRKHPCK"/>
    <dbReference type="OrthoDB" id="6433824at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051308">
        <property type="term" value="P:male meiosis chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007127">
        <property type="term" value="P:meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033587">
        <property type="entry name" value="M1AP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28642">
        <property type="entry name" value="MEIOSIS 1 ARREST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28642:SF1">
        <property type="entry name" value="MEIOSIS 1 ARREST PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106402.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="61684" checksum="A74C0D4061872495" modified="2022-01-19" version="1">MEKQHTRAVFARQPARILLVDFSLPFNAGICHLVHKSLEELFAVVCSMPGIPRIPYFGLFALGTHAENLFPLQHIKGNFQRLYNALQELKSFTSDSFMTMESSVNLGQAMREATVQFRRQAQTLRQMTGFSAQLEVTLLTCHQGPSISKQINEILPEMDLTSLRRIQVVTVLAGPSGLIFMDPSTMSIDIDSSPTIKIEMTGSPTSSQSSDPLALGAVETVTLEQDEISFQEFFRSWLHDCGTDREHLHLQLPPTTVEDDWLTLKCDLQESLLSSSQFPFQAQFDIHASMVPSKPIANQMSGKINTITAPIITLHTIQMVKVSGLHVCDSTVFGMPLLVKPTSCWQLDWEELESNQQHFHALCHLLQEKSLALVTRLDDNTPSPSYQTPKPSGHFILLPSSGLSLLLKPIAVKELILPTDCSQQEEQPVSDFLQNVTARLNRLEVADLYNPLMNTSQLHKSLMGTLVRDKGTRPVQSTGRQLKRKTTDTNTPSRMYPTQRCSSYLYPSTHAMPHGNTWGSTKGTSRGVKPPSAQRYHQPLAMESTTCYPHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZN78</accession>
    <name>A0A8B7ZN78_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="9">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC110987692</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022106349.1">
        <property type="nucleotide sequence ID" value="XM_022250657.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106350.1">
        <property type="nucleotide sequence ID" value="XM_022250658.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106351.1">
        <property type="nucleotide sequence ID" value="XM_022250659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZN78"/>
    <dbReference type="GeneID" id="110987692"/>
    <dbReference type="KEGG" id="aplc:110987692"/>
    <dbReference type="CTD" id="196294"/>
    <dbReference type="OMA" id="STHWFWE"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="24"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022106349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022106350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106351.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="18920" checksum="23C1456E1D3BF4B8" modified="2022-01-19" version="1">MASTARKCLQLSGKLVGRIGAYSAILYCTAHCITEYALDFTKCTGPSMQPTIENNDIVLTEHISTKFFNKVDKGDVVVLRSPVDPKQFLCKRVVGMEFDEVPVNRWKFLRTKNVPKGHIWIEGDNRTNSTDSREFGPVPLAMVRGRAVLRVWPWERRGYLAPHPASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNB3</accession>
    <name>A0A8B7ZNB3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110988136</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107088.1">
        <property type="nucleotide sequence ID" value="XM_022251396.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988136"/>
    <dbReference type="KEGG" id="aplc:110988136"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107088.1"/>
        </source>
    </evidence>
    <sequence length="308" mass="32208" checksum="8321E6A938032459" modified="2022-01-19" version="1">MGPKGGIPAARRCAQAKGNWPAQSPRRGPSCPRGSPPWCGRSALSIRPTHGRRSSPEPNKKDTGGLEGARPKEARQAGQAKREKGKARPSQRGPSAAGPVADLRVDRRRGSGRPAPIERERREPARTGCGGGDPFLAASEAPGGPREAREIETRPIANPSTSAGPRELWREEIRYGXPCGRAELQPRRRQAGSPTGDLPDGGNSAQPASRLVRPPPPGSRREEAGTMGPEGGIPAAARAPGEEVERKCRPGRAGEGEGPAAGGIPAEARRRARAERRRTPAPRPGSRGAAEQSEGHELAGPGPKGLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNC2</accession>
    <name>A0A8B7ZNC2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CDK5 regulatory subunit-associated protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDK5RAP3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106552.1">
        <property type="nucleotide sequence ID" value="XM_022250860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNC2"/>
    <dbReference type="GeneID" id="110987788"/>
    <dbReference type="KEGG" id="aplc:110987788"/>
    <dbReference type="CTD" id="80279"/>
    <dbReference type="OMA" id="CRLYEKN"/>
    <dbReference type="OrthoDB" id="340432at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14894:SF0">
        <property type="entry name" value="CDK5 REGULATORY SUBUNIT-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106552.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58108" checksum="83C8B59E942F4F2C" modified="2022-01-19" version="1">MQKTEELTAQQIENLPIDISSNKLLDWLIDRRHVNLKWQTAALTIREKINLAIQDMPEVDEIKQLLAGTYINYFHCLRIVELLKVSESGSKNIFGYYSSQRMKDWQEVVRLYEKENVYLAEVAQMLIRNVNYEIPSLKKQVAKLKQIQAECQRKEKDYQDNATAAKSEYNAECRKLGIKGEKIKSELLAKVKSLPEMLAVITEKSQGLSAVVEFYHAFVQFTIGGCSDNTRQSEIEVVPILRFFLQHGNATVYQWRTGKVPVSVETVTLSFLEDEEEQKEDEIDWGDIDAEAEGIDFGITLEDGGAETIDFDIQVTDSTSGGDVSDAEKGSTAKDDGIARGPDSFTILDHPPTRNNITNELLELEAFLIQRLNEMKGEIDILSANQFQSAPSILQMKTCDDVSAMLDKVREILNLLMDSTTQHLMLIKSSPKYVDRLTESLKQKCGQEEKMLASKEAVHVKCLEAIDEERQLMPKIDKLVANTRALQRQIEQDISSRYKNRPVNLMGSINSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPD0</accession>
    <name>A0A8B7ZPD0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110988246</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022107274.1">
        <property type="nucleotide sequence ID" value="XM_022251582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPD0"/>
    <dbReference type="GeneID" id="110988246"/>
    <dbReference type="KEGG" id="aplc:110988246"/>
    <dbReference type="OMA" id="KICHNCG"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000001">
        <property type="entry name" value="Dynamin 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000172">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="17">
        <location>
            <begin position="22"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="16">
        <location>
            <begin position="647"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="588"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022107274.1"/>
        </source>
    </evidence>
    <sequence length="739" mass="81813" checksum="38E40C9AE9E3ED85" modified="2022-01-19" version="1">MEALIPVINKLQDVFNTVGSDVIQLPQIVVVGTQSSGKSSVLENLVGRDFLPRGSGIVTRRPLVLQMIHIDANDTKTVGADGEGNQYGIGPGDEIQAEEWGKFLHTKNKIYTDFDEIRQEIQNETDRMAGANKGICPDPINLKIFSPKVLNLTLVDLPGLTKVAVGDQPEDIEVQIRDIILQYISNPNSIILAVTAANTDMATSEALKLAKEVDPDGRRTLAVITKLDLMDAGTDAVDILCGRVIPVKLGIIGVVNRSQMDINQKKEISDAIRDEAAFLQRKYPALANRNGTQYLAKTLNRLLMHHIRDCLPELKTRVNVMSSQFQQLLASFGEPVDDKSQTLLQIITKFAASYCATIEGTARNIETSELCGGARICYIFHETFGRTLDGIDPLGGLRTIDILTAIRNATGPRPALFVPEVSFELLVKRQIRRLEEPSLRCVELVHEEMQRIIQHCGTQEMLRFPKLHDHVVDVVTALLRRRLPTTNAMVENLVGIELAYINTKHPDFADASLVNALVDYQERELRKKKNELVPASASAIDQHTGKVDKVTKAVSQLATADGVTAPKDLRETSGSASTVGSWVPSWVRGSSGAPKGVTAEGAGEAPATPPQMQSPKVDKKTHGLNLLPDVPDVPLNRKLSSREQRDVDVIKRLIQNYFLIVRKNIQDSVPKAIMHFLVNHVQDNLQSELVGKLYKQEAIETLLKESEHMSQRRKDAQEMLQALQKASHIISEIRETHVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPN4</accession>
    <name>A0A8B7ZPN4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Development-specific protein LVN1.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107374.1">
        <property type="nucleotide sequence ID" value="XM_022251682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPN4"/>
    <dbReference type="GeneID" id="110988311"/>
    <dbReference type="KEGG" id="aplc:110988311"/>
    <dbReference type="OMA" id="NCIFAGT"/>
    <dbReference type="OrthoDB" id="10070532at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034875400" evidence="1">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107374.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27824" checksum="CEBC9F2CD9F6C482" modified="2022-01-19" version="1">MNPCSVVRLVALLAATVLVADADNYCCTAPQFVIRADQLQGIKLPSGQGLAQLNLVDIAFDFTNERLGEEIDSYSLGRLTKIKVIIDKKKNVMYTIIGQNCTKTEARGEFMQCIPKTAHFDGSSYLGDNELTLDTFSFPVDEPKVVSGNVSMSVTHGNCIFAGTLLVGEATQTEPPIPLVSSTSFVNFKRGIADPSRWFDVPSFCQQKKSTRARRSVRSVSDDHKDVMKLVSIFNTMMLPDVEPAKVLKPQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRH5</accession>
    <name>A0A8B7ZRH5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melatonin receptor type 1B-A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110988712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108183.1">
        <property type="nucleotide sequence ID" value="XM_022252491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRH5"/>
    <dbReference type="GeneID" id="110988712"/>
    <dbReference type="KEGG" id="aplc:110988712"/>
    <dbReference type="OMA" id="CLSYPWM"/>
    <dbReference type="OrthoDB" id="2105199at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="33"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022108183.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="39725" checksum="3E849E8415155347" modified="2022-01-19" version="1">MSKQNETLALMPSHAVTAIACVWAFMTALAFVGNLLVILSVLLAKKLRTVTNAFVVNLSVADLWSCLSYPWMIVAQVSPGGWPLASEVPCTVAALQFDTSLCVRVFTLAAVAVNRLVLTTVCRATYRRLYSPRKVIGMIATTWVVSCTIVFLPYVLEISEPGYYPEDKICSTKDGFHGRKFTYEIIESSCLVLSLTIAVISYAVLYARSVLQKRDQALRVDNQPHDEVVVTERRMFFLEISIRDATRQKITNPDQEQATTKILLIAFCIMLLLVLPFLIALVASADHKFVVYSMTIAILTSCVNPIIYAFGHPHFKAVLPKVARCRYSEILKPSYFLQAMLQPSSIALNKESSEPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRK8</accession>
    <name>A0A8B7ZRK8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">sn-1-specific diacylglycerol lipase ABHD11</fullName>
            <ecNumber evidence="3">3.1.1.116</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha/beta hydrolase domain-containing protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48596"/>
            <dbReference type="ChEBI" id="CHEBI:11152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:90605"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77107"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:77129"/>
            <dbReference type="ChEBI" id="CHEBI:186738"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + octadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77103"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,3-diacyl-sn-glycerol + H2O = a 1-acyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38503"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64683"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022106071.1">
        <property type="nucleotide sequence ID" value="XM_022250379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRK8"/>
    <dbReference type="GeneID" id="110987560"/>
    <dbReference type="KEGG" id="aplc:110987560"/>
    <dbReference type="CTD" id="83451"/>
    <dbReference type="OMA" id="FLGMSDN"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="12">
        <location>
            <begin position="47"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106071.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="32955" checksum="A2BC3CFAEF33098C" modified="2022-01-19" version="1">MMFVRNVVTSATYTRRLISKTIATSGKRSVKLAYDVIGPESSTSITPIVILHGLFGSKNNWATLAKKINRETQQTIFTVDVRNHGDSERGEGMGLTAMRDDLLILLKNDLQVERCILIGHSLGGRIAMVTALSEPQLIDKLVVVDVSPVRTEGVYQFPEFISAMKAVQFDQSVSLSQNRKHAGQQLQSVITDMGLLQFILTNVVERDGRCQWRFHLDGLEAGIQDILAELPTCHTRYDGPVIFIRGGRSSYVRVENLPAIKMLFPTATITTVEGAGHFVHSEKPAEFMQAVVPFLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRQ3</accession>
    <name>A0A8B7ZRQ3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987583</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106121.1">
        <property type="nucleotide sequence ID" value="XM_022250429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987583"/>
    <dbReference type="KEGG" id="aplc:110987583"/>
    <dbReference type="OMA" id="QHHMYSE"/>
    <dbReference type="OrthoDB" id="7881762at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033772">
        <property type="entry name" value="UPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF41">
        <property type="entry name" value="UNC5C-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17217">
        <property type="entry name" value="UPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="RHD" evidence="9">
        <location>
            <begin position="44"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="8">
        <location>
            <begin position="1392"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="478"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="874"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1465"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="830"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="950"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1465"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1513"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1540"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1557"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1568"/>
            <end position="1586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022106121.1"/>
        </source>
    </evidence>
    <sequence length="1626" mass="181725" checksum="15F973823285D563" modified="2022-01-19" version="1">MAAVEVSRFSPMQHHMYSELRPSTPVKRMSQTSNISQQVWKKRRVMSHLEVVEQPKSLGLHFIERGEKPPLNAYILGEKSTCEKTTYPRLMLMDYTGLAQIVWYLVADDSRHPHPYILEGEGCKDGVCTKTILAEGQIISFPGLYVRSVSRTDIKKTLEMRINTLREYLPGIEFRSKDTTEYNLNCVRICFQVLCQGQEEHHGNMSLLTRSLHSKEPSLQREPRILSISQCKGSVQGQEELTLQVTNLKTDDVFVFFHCESLEPRSSWQAFANVISISRQKSKPVDIVVETPPYPDKKITEPKTVAVQIRLMDSSVSNTIKFTYTPKPKGVTKIDQKYKLKEPIYVRYFTCPDVSTDVKPILKMAVDGKDTENSVCDPVYVYKREPRTLKKAKPEKGDAACQTEERYLRTDLGLEGYDSEEEIGIADDRVDYNRLERYRSLMMESESPANTSLTNGTERLVQTGAGLSQHDFTPKGVLGSLLSSKSNHSASSVRNQVGVHTSSRGNSSAFEKLTRVLSEVNLDSQSRCEGESCSHSESLEKSVGNCSFSSDKDIKDNQEESPPTDNQVVDAFINSTTNCLFGRFQCVFLIETTPKVQEIVLRPPGAANVPDLTGSSLYIALADKTKFPINMNPEGLVAVKDIEESQFQEEAYFDWHRLKQKNLINIIGLVKLKAVHSVILELPEEGCLVGYISRTDPAILKGSALKWIEQISKALQQLHDSGLAHQEIRLENCLISGGNDLILNIPSNLMMDGTQMEVGSAKMQDVHSFGVLGLNLLKYCGVMEDISSCLEFFQDDKMTKALTIQAVVKKLQCFSQQPSKMVPSFEVDPSSPTHELSNQNANFDFDPESYSLSLTPDSGLVCPHEIKHPAVSSLTRAERTYSSSSRESAFSDASLKSDDSLNSVRANSVVTSQGETAAATPTSSQEGDTPDGHGSSPPQEPEESEMGDEGDGRSGEDGKEESNGQDWDHYQNDKQDDSFRSHLRPPRVMKCVDHTGGILELFDGEVCLEIPPGALRDGQVEEITLSVVWNDKHIPPLKLTDMNAAPIVQCGPNGLRFEKPVLLKLPHCAVVPDPKQCKMTVHYSETGEDQGELPHWERISKPEDSNMAVEYHDRYFTLSVSHFCEFTVTIDGSGEESLAKNIMIVGYGPKLKSFDEDQQIRVYLYEDNEIIRERIHQEEQNLGGNQLDGPVKYQFHKLHRGSMIIEVKFHTASWLLTSARQRVEFSFSYMWNTKPWNRCKFTFSNSTNKATQFRCDIEAKQKDNDDIAQIEISNHVKISSEASCPEARGSARCDDKASFDAPTWPCGTTHISYRESQMYRRDLSYEGSGFGVPLCGSSLQTQSSGLGLKSAEEFGAFSLTSICSETLSKPLIPFEVERDLCVLLDPEGPAGIGNNWKLLASLFGINNNYIKLWESKRSPTSQVLSVIQHERKIQSLADLKEKLTEMRRLDAAKVIEDYEVQMCNRSTRSMQPTSEEPMALSNTPSPDETKPALTGNREFFTQPPSTFPDQKSIESSSSSSSAMVSGSSNQNMIQLAGSDTDMTGQGLSSSYAQHHSTRQELTPHPETVHSSPQNDFLSSPRNSMGTPDSCLERSDNTPWKAPTQRLADENSNMEFLKDAVKRNLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZS51</accession>
    <name>A0A8B7ZS51_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110988740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108234.1">
        <property type="nucleotide sequence ID" value="XM_022252542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZS51"/>
    <dbReference type="GeneID" id="110988740"/>
    <dbReference type="KEGG" id="aplc:110988740"/>
    <dbReference type="CTD" id="6194"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022108234.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28662" checksum="C9C55893EBF11EF1" modified="2022-01-19" version="1">MKINVSYPATGCQKLIEVDDEFKMRAFYEKRMAQECSAESLGDEWKGYIVRISGGNDKQGFPMKQGVLTNGRARLLLSKGHSCYRPRRKGERRRKSVRGCIVDSNLSVLNLVIVKKGDNDIPGLTDKTIPRRLGPKRAGKIRKLFNLSKEDDVRQYVVKRLLPEKADKKDQKPRYKAPKIQRLITPQRLQRKRHNLALKRRRAAKNKEQAAEYAKLLAQRQKEKREAHLKRKRSASMRESHRESTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSD8</accession>
    <name>A0A8B7ZSD8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore complex protein Nup98-Nup96</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110988877</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108488.1">
        <property type="nucleotide sequence ID" value="XM_022252796.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988877"/>
    <dbReference type="KEGG" id="aplc:110988877"/>
    <dbReference type="CTD" id="4928"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:telomere tethering at nuclear periphery"/>
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        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
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        <property type="entry name" value="Nuclear pore complex protein Nup98-Nup96"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase S59, nucleoporin"/>
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    </dbReference>
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        <property type="entry name" value="Nucleoporin_S59-like"/>
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    </dbReference>
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        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nup98_GLEBS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="16" id="KW-0472">Membrane</keyword>
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    <keyword evidence="15" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="14" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="19">
        <location>
            <begin position="766"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="636"/>
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    </feature>
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        <location>
            <begin position="917"/>
            <end position="986"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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            <begin position="1084"/>
            <end position="1104"/>
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        <location>
            <begin position="7"/>
            <end position="23"/>
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    </feature>
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        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
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        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
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            <begin position="288"/>
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            <end position="943"/>
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    <sequence length="1924" mass="207375" checksum="F6CD6ACC8DBEE71F" modified="2022-01-19" version="1">MFGANKTPFGTSTFGTGSFASPTATPFGQRTNAFGSKAQGTTGFGTPATFGAQTPAGSLFGTGTSGGLFGNTGSTFGQTSSSGMGFGSNTSSAAGTLFSSTSNAGTTGLFSTPTTSSSFGNFGSKPFGATASTGLFGQTTTSTTPFGQTAAAGTSSGLFGAGSGGLFGSTAQNGTTVKFNPVTSTDTMVKSGVSTNVNTRHQVITAMKEYENKSFEELRAEDYVANRKGPTGSALLGQGLTQVDNKAGGLFGQSTTSSGGGFTFGQNKPPFGAGTQSGFGTSSGGLFSGQQTQQSGGLFGQKTGFGATASTGFGFGEKSTSAFGQTASKGLFGQTSTTQSMGLFGSTPASSGTGFGTSSTFGGTSGFGQTQPTGLFGKPFQTTTTSSGLSFGTNSGTGLFGQPSKPGLSLGTGSTSGFGGFGSGTSQSTSLFGNKGTTTGFGGLGTGLGGGLGTGFGTANAGTSLFGGATSKPSTLGGLGGFGTTTGLGGGLGAGTGLGIGSNTTGIGGATVGLGVQDVQAQQQLLTIFNSPYGDNPLFRNRLTESDKKEDILKPTSKAAQKALTTPLQHKVSARPSAKLRPKPLQGVSHKSKLFEGLDDEDPTLNSEMFIPRRSVKKLVIKKKEDKMEADHLLNSSRSLAQEDDLLSPVPTYPNDTTTKQPIATQELSPSSNDVLETPGGTRLFSKPQSSQHNLSSSSSKKQEDPDCTITDLNVKAKTPSKLNTSDMSSTASDLDQSASLADGIAVDENQENTPPPHPGGVVLQRAGYYTIPSMDELEDMVEIAEDGEVRLYVEDLTIGRVGYGSVFFPGVTNLANMNLDEIVHFRRKEITVYPDDTHKPSVGERLNKKAEVTLDRTWPTDKTTRKPITDVERLITLNYEDKLEKATAKLGAKFIEYRPETGSWVFQVQHFSKYGLSDSDEEDEVPDKDAKKQLPQQKPSQKATAADKLPTKQPASKQPSLKAPSGGRQQAKEAFPSQQEEEPMRDDIDMEMMRDSPIRGLGGYSPKPYLNGHLGDEVEGQEAQLLNVQGDEEGEEEAVASSHRLANVLGMNTHRMQVMKGSFFADEEPVEYDYRLRSAPVPQTRPSFFDSPSRGSPAPKMEDSFQERGLNKSMGGGVWRPRPLGSPAKYLAGMTDPSDVKGSPVPITIKEEMVNRRDYFMSSHFAAPKTLPPPFAGPQPLHISSGMTQDRPPRLVGSRPQQTILPLNQSVVAGKVPCLADAGLVMSRSFRVGWGPNWTLVHSGKAVGQRMTVPDIKKEAITFPLLTTKQPTKSTLDASPFTLTLEKVNLAPHLLAADNKVLDLHERSLDVQLRHSRSSSQQSCPVFAPQRGVDCLHHYAKTALRDVQDELTADLDTLNHSLLVWKLLVALWGRLPHQDAQELDPDGYPFRKARREAFSEWLASASRQHVNREVEDAKFKDMGHIEAVFSLLTGWQISEACAEAQRSGDHRLALLLAQAGSNEEGKQLVAKQLSDWKEMGVDKFIAPEYLRVYALLAGMLVWPSAYGVINTCQGLDWKRALAVHLCSTFRHSCSPVASISDALKEFETGFLGQSTLQHYCPVPRPPYMENNPDMYPEKRCDEIGAELVEEVAEDGDERFVVLDMCFHLVKLYTDRSHRLERVLAPTTHTGYHLDYRLSWHVLQAVQALGFSHLSDQDLAHLHTSYASQLEALGLWHWAAFVLLHIQDDFRREDVVRQLLQRQCLLKRSEENAAKERFLVNQLHIPPKWIFEAKALRAQYEDRAPEQAWHLLQAGHWNDCHSVIVKHLAADAIISENYNYLLGLLKELVPSERSITIQDWTTNGQVFLDFINIVQRLDHLQHTEPTVYELEKLYPDVASLCSRVGSVTCRTAKDRLCQSEMAKRTANVMKAVLTLQQQSLHPDKSVRLPSRLLAPHVGKLPMPEDYGLQELRELTRSYMVELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUF1</accession>
    <name>A0A8B7ZUF1_ACAPL</name>
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        </submittedName>
    </protein>
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        <name evidence="3" type="primary">LOC110988839</name>
    </gene>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108420.1">
        <property type="nucleotide sequence ID" value="XM_022252728.1"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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            <begin position="65"/>
            <end position="178"/>
        </location>
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            <begin position="72"/>
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            <begin position="103"/>
            <end position="119"/>
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            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108420.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="48896" checksum="CC94CC76298032E8" modified="2022-01-19" version="1">MASTATDVVVKAVEGIKQDAGSNVSLLQRPPLGKQVGQQEKCPCKHQASSAPLTHAAGLGTAQLLFEPTPPSHKKPPRAVSPHVRKIQSAKARLVPSSSSSNVKDDAILPKGGVLDRQRPNSAHVPQRERGNRHRPGSAIGNRPVPKQFLTLETNQQRSIPDSSGKQGAENTKKAVCESEDVEIKRWKERRKDKPEKTERTIPEGIAQLRPWLTEDVPVDWCGVDASSCLIFLPSLCQQLDDLPIVPPIQHSEDVLPHTVIPPPPKPFDPKKLFHYNVEKHIPPEPTYESRSQTRTRRGIYAADGSLLYDEEKYSVNRTEEIIRKEIEDLENLLHGIGNADSSNVMVQYQADISKLQWTVKDTLVKCYQIESHFQKDKPEEQPDLFGLRAYIKEKEAILNQIRARREACMMELERLESEVGMTMQSQVLQAFRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVX8</accession>
    <name>A0A8B7ZVX8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bombesin receptor subtype-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110989542</name>
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    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109703.1">
        <property type="nucleotide sequence ID" value="XM_022254011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVX8"/>
    <dbReference type="GeneID" id="110989542"/>
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    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022109703.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33913" checksum="5C8ED5224070FB07" modified="2022-01-19" version="1">MRTRTNAFIFNQAVIDLLGSVVILMQTDVPLPDPLPDNAAGWIWCHIWISNFMIIIFYVPSTFNLLALTLERYFAIVYPYKYQITFATNPRLKVGVTMACCWILGVAIKSYTILIVEKTADGKCVSRPISGSTVIGILTVFLQYIIPAAVMLFAYIHTSVELKRQAARVGPVMTMGCSVSSADRPVSNAAPQENLTASLLRARRNVFKTLLVVFATFLVCWSPNQILFLMFNLGWKVKFSDWHFLLTLALVATNSCVNPFIYALKYQQFRNGVRQAFCQGRPSVNSIPYGNDNPTTRTELNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWB5</accession>
    <name>A0A8B7ZWB5_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">COMM domain-containing protein 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988528</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107826.1">
        <property type="nucleotide sequence ID" value="XM_022252134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWB5"/>
    <dbReference type="GeneID" id="110988528"/>
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    <dbReference type="OMA" id="SQQWGEH"/>
    <dbReference type="OrthoDB" id="76101at2759"/>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="F:NF-kappaB binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04755">
        <property type="entry name" value="Commd7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047155">
        <property type="entry name" value="COMMD4/6/7/8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037358">
        <property type="entry name" value="COMMD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 4-8 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16231:SF2">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21672">
        <property type="entry name" value="COMM_HN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="1">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107826.1"/>
        </source>
    </evidence>
    <sequence length="201" mass="22697" checksum="7A65A552B11B2E53" modified="2022-01-19" version="1">MAATFHFAAETPPDSMFSEIQTLNKFNEEQFSEIVSIVIAFLLEPDKSNQLISQLDDFARDQGVSVAPLRNIVRSLITILNNAVRRNMTPTQLEEDLVSLGLSEERATHLANQWKSNLIGLSRTAVGQTLMINQLVDMEWKFGVTAASSELQQVGSTFLQMKLVVNKGNKTENVYMELSLPQFYSFLHEMEKAKLSLEYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWM6</accession>
    <name>A0A8B7ZWM6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Metal-response element-binding transcription factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110988578</name>
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    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
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        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Polycomblike family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107936.1">
        <property type="nucleotide sequence ID" value="XM_022252244.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="110988578"/>
    <dbReference type="KEGG" id="aplc:110988578"/>
    <dbReference type="OMA" id="CPDESWH"/>
    <dbReference type="OrthoDB" id="10033786at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="metal-response element-binding transcription factor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KDM4-like_Tudor"/>
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        <property type="entry name" value="MTF2_PHD1"/>
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        <property type="entry name" value="MTF2_PHD2"/>
    </dbReference>
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        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF21">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14061">
        <property type="entry name" value="Mtf2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18104">
        <property type="entry name" value="Tudor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="164"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="573"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008084"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022107936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022107937.1"/>
        </source>
    </evidence>
    <sequence length="710" mass="78709" checksum="06F8A244EFC7B227" modified="2022-01-19" version="1">MEKSSPRKAQPRPEAAPDPSLPGTATIIQTDCKPIFDNNNTVLETEIGSTASSIASDKKMLPPNPVNFTLLGEEVGPAEDAVKQSDSEAEGAGCSSGKKDSLKKDCEFVVGLDVLARWNDGLLYLGIVSKVIPHQKKCLVIFEDKSEHWVLFKHLQKGRTPNSEITCCVCEGDQSEPPNEIVICDRCGLGYHQLCHQPAIDSHKLLCPDESWHCRQCVFVNSAKVGGALKKGPGAKVFQEMKQSLPYKLDSLHWDSAHKTNTEQCYCYCGGPGEWYLKMLRCCRCMQWFHEACVQCLEMPMLYGDGFYIFVCSVCNAGPEYLKRLPLKWQDLAQLVLYNLTLMHRKKYYDFEEEIIPYLTEQWYNLQVSHLGATTRSEKQERFLDALHSSKARFACGKEVKKKQNIWGLRIRKPPIPPTIILPAIGQITDEVMNDLKMTGRKVMTFIPVESNSPVPLKPAKRKRKSVAETPEELERRSINARKMFEQAIKDGVPRPAFSLNQSYTGYSGGGMALANLTPVSEGQSVLDTIRPFETVYSGSTGVPLPVSFSQHSSVASGDTGSDYSATTVLAGQSSASADGESGDSNNNDNNEEGSGVDSLKRHRKHGSWKRKRKHLHPSTPSKERTPTSPNPQPAAKTISHPPSRGESPEKLATTRLNGAVTMAELKRSMSNHYGAEGRLACGEKHQLLGRRVTPDGKIQYLIQWEGISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWP7</accession>
    <name>A0A8B7ZWP7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110989628</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022109849.1">
        <property type="nucleotide sequence ID" value="XM_022254157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWP7"/>
    <dbReference type="GeneID" id="110989628"/>
    <dbReference type="KEGG" id="aplc:110989628"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF163">
        <property type="entry name" value="AT16346P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022109849.1"/>
        </source>
    </evidence>
    <sequence length="198" mass="22080" checksum="E7D8A06D9BB4EA3A" modified="2022-01-19" version="1">MSAGKCQITKPAPDFSGPAVMPSGEFKDIKLSDYKGKYLVFFFYPLDFTFVCPTELIAFSDRAKEFRDIGCELLACSCDSQYSHLAWTNTPRKKGGIGNMSIPLLADKSCRIAKDYGVLIEEDGVSFRGLFIIDNKGILRQITINDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWRPGAETIKPDVKKSQDYFSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX38</accession>
    <name>A0A8B7ZX38_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C7orf72 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108106.1">
        <property type="nucleotide sequence ID" value="XM_022252414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX38"/>
    <dbReference type="GeneID" id="110988667"/>
    <dbReference type="KEGG" id="aplc:110988667"/>
    <dbReference type="OMA" id="CRSYHWK"/>
    <dbReference type="OrthoDB" id="10035002at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027867">
        <property type="entry name" value="SPATA48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34759">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34759:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15073">
        <property type="entry name" value="SPATA48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108106.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="40302" checksum="F2A20F00EDB65D47" modified="2022-01-19" version="1">MEDAFNTHASTTYRISYPPHTCILPPIKFHQLPAIQLRDKPKLAPREFPISPAGPSRGWEKGTGQVLLPDIKSFIDKPIVRDPPPQKKVINPPPEKPKPRQKADRQPKADNHEPDDPLQRLAEPLPPVVLRCTDGYPEKIEEGWVEELCRSYHWKTSSKEAAKEGCLRVPELKPPLTTMEPRSDFLSYRSMRYDSRQLPWQRVAPVWDRVQERPHVGCNVTSRLIGGGAVKATTENAKQSASKKKEDIALDDKILQLVREEKVPSMFVRKCPGYAGYVPRSPLRVSMETASIFPDQRTMSTMKSSYRTFPTREYAVKEFAHKGPLSRTVTLTYPYNPYNKVESRAEEIEHKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY05</accession>
    <name>A0A8B7ZY05_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110989903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110294.1">
        <property type="nucleotide sequence ID" value="XM_022254602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY05"/>
    <dbReference type="GeneID" id="110989903"/>
    <dbReference type="KEGG" id="aplc:110989903"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="2">
        <location>
            <begin position="9"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110294.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="23021" checksum="E4BC085BFCBD2D3B" modified="2022-01-19" version="1">MSNEDETKKEQLVQRAKLAEQAERYDDMAAAMKSVTELLDVESPSASGLTNEERNLLSVAYKNVVGARRSSWRVISSIEQKSEGNEKKQQMAKDYRSKIERELNEICHDVLVSGFGVNLLWHAVTCVRSLHVHVQCTTRVMYTPTSCTCQLHMADKVASGQLILGKIYLGPMPTRLRKHLMLGPGHCRCQACQLEHVVLDFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYT0</accession>
    <name>A0A8B7ZYT0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Krueppel-like factor 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110989875</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022110252.1">
        <property type="nucleotide sequence ID" value="XM_022254560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYT0"/>
    <dbReference type="GeneID" id="110989875"/>
    <dbReference type="KEGG" id="aplc:110989875"/>
    <dbReference type="OMA" id="ETYKNRE"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000232">
        <property type="entry name" value="Krueppel-like factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000926">
        <property type="entry name" value="Kruppel like factor 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF174">
        <property type="entry name" value="CABUT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="100"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022110252.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="32575" checksum="B22DFCAD9EAD8650" modified="2022-01-19" version="1">MDPGACTSFLPNHQTNLDYSPVDMDVTSAAECLLAIAKSRPPWKPPVIASTPRPAEMGYATPPYDRAMTNEDSELAALPNPLFMVARILADLETYKNRELAPSPTSDCSSSLEFSQDPFTDIPPTGARLKGNKTTKRRARKTSTCDENAKVGQRNKRAAKKRSSDHLGPDGQPIKKHKCHYMGCDKMYGKSSHLKAHLRTHTGERPFPCTWQECSKRFARSDELARHYRTHTGEKRFCCPLCEKRFMRSDHLMKHARRHANFHPSLLKRPRSVADSLSDRSANSSPVNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZ85</accession>
    <name>A0A8B7ZZ85_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein rolling stone-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108896.1">
        <property type="nucleotide sequence ID" value="XM_022253204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZ85"/>
    <dbReference type="GeneID" id="110989083"/>
    <dbReference type="KEGG" id="aplc:110989083"/>
    <dbReference type="OMA" id="SYFAPGH"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049352">
        <property type="entry name" value="Rost"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF49">
        <property type="entry name" value="HEADBUTT, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21534">
        <property type="entry name" value="Rost"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108896.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30638" checksum="F04FF0858E8D3C85" modified="2022-01-19" version="1">MAIGYRCYRPKLADFGLTTKDSSVFYSAQWTKWPRFHYVFVLYRILVALYVLGIFIMVLVHDVRLRGGQSFVYLTMLAFIVVFIYLMVAGFVAWLDGIILRARNHEVMAIRHKIQWFFFNVTIDTNLIVTILYWSFLYSPEQNPPSFRNFNVHATPAIITTLDLFLTAIPVRFLHFIYPLGFAISYIVMTLIFWAAGGRTPSGPIYPFLDYDDDPGLAAGGICGAIALGFVVHCAFWCIYKFRVWVWTKCRGDQISDELSIIDTPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3V7</accession>
    <name>A0A8B8A3V7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110990081</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110990081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110581.1">
        <property type="nucleotide sequence ID" value="XM_022254889.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110582.1">
        <property type="nucleotide sequence ID" value="XM_022254890.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110583.1">
        <property type="nucleotide sequence ID" value="XM_022254891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3V7"/>
    <dbReference type="GeneID" id="110990081"/>
    <dbReference type="KEGG" id="aplc:110990081"/>
    <dbReference type="OMA" id="KQRPEWN"/>
    <dbReference type="OrthoDB" id="10575194at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022110581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022110583.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19390" checksum="82612A6AFA1CDF7D" modified="2022-01-19" version="1">MEADQPPLEERDGAQEQMTVASPLDDIESICSELENVQLTDDETTTLLHEALELNKRLKEELRRREVDDGRARDATVGGAGVGRRGDAVSASLPPIHPKKGLSVTQRRIYNSVEMGERSHKTKNRRVAVGAGQRKAHSADGGHQQTASPLTRPRARGTQSAESKQRPEWNDRFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A6Z0</accession>
    <name>A0A8B8A6Z0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110991022</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022111781.1">
        <property type="nucleotide sequence ID" value="XM_022256089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A6Z0"/>
    <dbReference type="GeneID" id="110991022"/>
    <dbReference type="KEGG" id="aplc:110991022"/>
    <dbReference type="OMA" id="GQLIMQY"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07141">
        <property type="entry name" value="ALDH_F1AB_F2_RALDH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000029">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="49"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022111781.1"/>
        </source>
    </evidence>
    <sequence length="521" mass="56889" checksum="A78D72D6B6823DB9" modified="2022-01-19" version="1">MLRVAANRLLSTVGRSGHLARCSSSSAALPQPQTSPDIHFNKLFINNEWCDAVSGKTFPTINPATEEKICDVAEADKADVDKAVEAASAAFALGSPWRTCNASHRGFLLNKLADLIERDRVYLASLETFDNGKPYSASFTADLDFTIKCYRYYAGWADKIEGKTIPIEGDFLCYTRREPVGVCGQIIPWNFPLLMQAWKLATALAAGNTLVMKVAEQTPLTALYIAELTKEAGFPPGVINILTGYGPSAGAAIAGHMDVNKVAFTGSTEIGHLIQQAAGKSNLKRVTLELGGKSPNIIMSDCDLEDAVEQSHFGLFFNMGQCCTAGSRTFVEDSIYDKFVECSVERTKKRTVGDPWNPSNEQGPQVDAEQFSKILGLIDSGKQEGAKLLTGGQRQGDRGYFIQPTIFGEVKDDMRIAREEIFGPVQQLLRFKKLDEVIERANRTNYGLAAAVFTKNIDKALQVAHGVRAGTFWVNCYDIFDIAAPFGGFKMSGVGREKGEEALNAYTETKSVIVKIPQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XH76</accession>
    <name>A0A8B7XH76_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DnaJ homolog subfamily C member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110973558</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080149.1">
        <property type="nucleotide sequence ID" value="XM_022224457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XH76"/>
    <dbReference type="GeneID" id="110973558"/>
    <dbReference type="KEGG" id="aplc:110973558"/>
    <dbReference type="CTD" id="64215"/>
    <dbReference type="OMA" id="AAYWERK"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000180">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily C, member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0732">Signal</keyword>
    <keyword evidence="1 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034868107" evidence="11">
        <location>
            <begin position="35"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="13">
        <location>
            <begin position="313"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="472"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="13">
        <location>
            <begin position="475"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022080149.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="61429" checksum="E7A860BEDEC2E867" modified="2022-01-19" version="1">MSQSRRRVRLFPNFQVLFVTLSFVLLCFVSNGNAWDSADFELFDLVEEVQLNFYDVLGIEKTASAAEIRKAYRKQSLLLHPDKNKDDGAEEKFRQLVSVAEVLRDPDMRERYDQILEHGLPNWREPVFYYRRVRKMGLLELAVLLFIIMTVGHYIVLWSIYWERLLELESIIPKKKKDKKAKKAARQAANPSETDDDVLQDLAPDDPLRPAKPQLADALPCKLCRLLLTVAVSAPSALKQAKLELEIWRERRRLEAELATQEKEEGVEEDGGGVKEKVKKRWKVEPTMYEYAPSTAEPVTYTPQGMAQDNERTSNTKSGDWTQDEVTRLIRAMTRYPGGTSARWDKIAEEISRPVDEVTKKAKQIKSGGYIVNVETSAQGITGAVEHAVTSKTGKTFPNDEITIASSDCTTADPDDSQKENQRKRKTAKPLKTAERTLLISQASDRNLDCHQSDEMERESKEKEQDAILSGGGAGSWSQRQQKILEKALTVYGKGVAERWEKIAEAVPGKTKEECILRYKELVETIRRRKQGNTGPPQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJJ5</accession>
    <name>A0A8B7XJJ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 148-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080125.1">
        <property type="nucleotide sequence ID" value="XM_022224433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJJ5"/>
    <dbReference type="GeneID" id="110973542"/>
    <dbReference type="KEGG" id="aplc:110973542"/>
    <dbReference type="CTD" id="130940"/>
    <dbReference type="OMA" id="KLKKYWA"/>
    <dbReference type="OrthoDB" id="448087at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039902">
        <property type="entry name" value="CCDC148/CCDC112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21549">
        <property type="entry name" value="MUTATED IN BLADDER CANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080125.1"/>
        </source>
    </evidence>
    <sequence length="623" mass="73138" checksum="E99917A4B901D685" modified="2022-01-19" version="1">MTGRDYRGFLSQHRAGPREIGRAYESDKLLIRMTEGLGSSRYTAPDYEKLKALALEKKISGNRSLIKVNRLAAISRASQEKSLLKQHGMVWQREVGRLDAARKRAESEQDSFFLSSTSEQSEISMFMLEAEDYQMELEVDRKAFKGATVDPLWTLREDLQAWLTENSPQFHPGSPRHEELAEQHTRITETIDSVKEQQQGILNKLWHEERALEQDLHSNYLRGLFAGAEKWVVEGIPTEAQVLICPDMELRSSVLLEFGLLDQKYLVRLRDLDKMHSDVLRSDTGGWDAADHFAYQVIVDQYPHDLSNRRALYIDRLRRQLPHKTRNDIVAHEDWSLHHRFYVERRRTLINCWARDKQELYDKAVTVFADACLAEELRQATAINRQRQDEICQQLGQKVQRWKEQKAEAMRLEDEIASQQRRQLEEQRAREEEADQKRRAVDKQKVEAYHLKQRKEQEAREKENKKRLADIQEAMELQAQKDRERVAYREMLLEERKQRQQDERRKEAENEMERERRLDALRQMVEVHVENDPQRVFQNTKAFKAHLGIGVDEDINIQKPLFDAKGFTAEQVTSDPRFKLEQALRKAGLHGNPYARAMMGHTKPLKPPRRDQESTVFKDLAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKK1</accession>
    <name>A0A8B7XKK1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="22 23">Adhesion G protein-coupled receptor A3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22 23" type="primary">LOC110973839</name>
    </gene>
    <organism evidence="21 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080676.1">
        <property type="nucleotide sequence ID" value="XM_022224984.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080677.1">
        <property type="nucleotide sequence ID" value="XM_022224985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973839"/>
    <dbReference type="KEGG" id="aplc:110973839"/>
    <dbReference type="OMA" id="DETEEMH"/>
    <dbReference type="OrthoDB" id="10031018at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058808">
        <property type="entry name" value="GAIN_ADGRA2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF4">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26588">
        <property type="entry name" value="GAIN_ADGRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665441" evidence="16">
        <location>
            <begin position="34"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="789"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="821"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="869"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="902"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="987"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1016"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="250"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="18">
        <location>
            <begin position="334"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="17">
        <location>
            <begin position="586"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="19">
        <location>
            <begin position="752"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1086"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1155"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1237"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1274"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1086"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1159"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1338"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1407"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022080676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022080677.1"/>
        </source>
    </evidence>
    <sequence length="1421" mass="156253" checksum="7A204DE668202A3C" modified="2022-01-19" version="1">MTTTPCRFHQPFQLAHALGLLLIFALLVISTLGSLGVDACPSSCTCNLVSRRGDREGRGREGRRPSRREVVCSGRGLKAPIDPTTVPKDTVQLDLSNNQITSLRQNTFAGLSSLLQLNLSGNCISYIEPKSFDGLDQLQKLDLSRNRLGGVNNSMFVGLGNLVDLSISYNQISTIAAASFDRLQEIVYLDFASDYLVCDCQLKWIVRWMKDNKVRIADTTVCAFPQSMRGEKVRQLKRKELHCDWPLELPMFELEPDNSQVVFKGDTIPIECRATYLEGAEERIQWFKSGRLLKTNLTAGVNITTTVLRDQARIRSTLLLYKIQMDGTSIWDIECRVTTSRGIKRKRVTVIILDNNDTKYCPPKETLDNRGTFNWPETIAGITESIVCPHGVGTSHMGSFSQAVATRKCNLRGVWEDPDTSQCEYANELTWRLESASLMTYNNLTMAVPIAKEIESSTADPAVIQDKMDITFIARTLDKFSRLRNVELGEVMINIASNVMEVRPEILKQSQAYNQACSKIVQSLEKFAQEVPRSSGQVFNHKAANIAMEVFNLDTDTFTGMACASFRTSPLPANAPLDQETGLQDFRCFMGDTDATSTQMTRSKGVVEASIQLPSSVVAKVTEDNFQLQFFIYKNSQLFPSVTNSSNTAEDRGRRQVAGQVISSKIAGSSVRNITSPVILNFRTPAGGRDQVPGYWDYTTYPEGAWMSRGCTIIRQTGNLTTVHCNHLTNFALLMDTTSSGGVSKVRSIDLLHPAIYVGSLIFVVFVFWTMVSYICFNSNIRLKRKCRHSLMNMCFGFLNLVMFFAGGVNRTEPLLLCRVVGLGIHYFSLCCLLWIGIGARNLLKGLTRKERVLPPGEAPPPPRPILRFYFMGWGIPMIVVGITAAANIGNYGGEQICWMDFSISLAACFGVAGFFVLITFIMFVAVAVRLGWKPPEESKASQPSTDLDPHTNIDSESVVTHRTALSTVSSILDGEYTYARQLKASVILLLGFLITWTLAAMAVTQTPFLAMLFSYLYGAAIALLGLFIFMYNCILRGDVMYNWRRTCGCTKSRNAYAVALSGSHPGSQVGSQVIPPGNGHVVQRCQSASSVDSNVTNRSANTNQSNHSLKSGSRKASKCNYVPSHTNTGTDASIDSSTQDTVARPHMYEKARGNGYAHRYHHKGRNRPKGYKHSRYSQITRDTSDAGATPEVCSVVQPTCYADSVSSGSVMARVPPVVMGNVTGEHEGSCGLQPSTLSGTSMQSAPAGPVTTQPMRPQWPMVRAVELPNLPPQGMPVLAAHSSNNSIGKNVPSAADTQPHPAVPHITPLDRQEGAALRRRASREDSRRSSGKNKIAKGADDKSLPREEVPLLENHPSTSEPPTYDEATRATPMDDQVAKQPLEAKDVEESAMDGAAVEMDSLSQADHSDQDGSDKRETSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKT8</accession>
    <name>A0A8B7XKT8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PC-esterase domain-containing protein 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PC-esterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080751.1">
        <property type="nucleotide sequence ID" value="XM_022225059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKT8"/>
    <dbReference type="GeneID" id="110973870"/>
    <dbReference type="KEGG" id="aplc:110973870"/>
    <dbReference type="OMA" id="VMEGNFY"/>
    <dbReference type="OrthoDB" id="9975373at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469:SF0">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14469">
        <property type="entry name" value="SARCOMA ANTIGEN NY-SAR-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080751.1"/>
        </source>
    </evidence>
    <sequence length="444" mass="51088" checksum="1A355E08A21EB851" modified="2022-01-19" version="1">MAIFLHEDVVNLLWNKFVVIIGDSIQRSIYKDLVSLLQTNTYLSENSLKKKGELSFMDDVLIEGGKKEEMSNGINYREVRQYKTDYHLVRFYFVTRAYNKYVETIFIDLAKEPKPDVVLMNSCLWDISRYGPNSMKAYKTNLEKTFYRMQKTLEPDCLFLWNTALPVANKIRGGFLLPELEFLSETLRLDVMEGNFYAKELASAFDFDVLDLHFYFRFQLHRRVADGVHWNHQAHRRMSNLILSHISEAWGLSVPRRLEAWHQPPSVPPQSPVVFDITETNFHTDIALSAPPQAPRARRNSLGDDWGNVNQFIDFDKVASPKEDPTCKNPASNTTTRPPTPSSNNKVEKHPAPTPPMPINSICCNANASNGPMRPAAQHRQATRYNPYGGGHTGGLNMGHGGRYNSGPGGPWRAAPFWKELEDRRRQRMEWERQQQVNWNGFCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XME7</accession>
    <name>A0A8B7XME7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair protein RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081337.1">
        <property type="nucleotide sequence ID" value="XM_022225645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XME7"/>
    <dbReference type="GeneID" id="110974190"/>
    <dbReference type="KEGG" id="aplc:110974190"/>
    <dbReference type="CTD" id="5893"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="560"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022081337.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="73602" checksum="DF2A45C6606A482D" modified="2022-01-19" version="1">MTATHNQSDRSTSFGQAEFSQEEHAAIQAALRQKLGPEFISQRSGAGGQKLAYIEGWRLISLANEMFGFNGWSHSVTHQNIDFVDQAGSKYFVGVSAFVKVQLKDGVFHEDIGYGVSEGMRSKALSIEKARKEAVTDGLKRALKSFGNGLGNCLNDKNYLRCIGRAPKPPEETLNVTDMKRGMVDSKILEARYQPQTKHQGCPEGRWGPQEKQCRQTAAKPILGETEPIQARLLPGGTNAAGSGPTAFFAVPQERPCPPHTPPPKCVAPAAMPSKPHGQNHPFPPGSLHQDAKPKQEVPSSASHHSIPARMPSPKNKFATPSKPQVEIPTTPVNEAPLTLRQVTVKTEPFPAPAPPGTLSEQRVESVAQKQINLVCQTDKKVCVEAMDTNAVTADVHCVSPEAVMSAAVDVPTPPDGLSSTEPTPEQQLRQRKLRQQQKQREFREQLLRKQQQQQAEQPHQVAQPQEQVEGHNTARQHPGMADHQEENLAVPSAEDPLFPMATSTPLDTVLLTTAGSAMSCPNGAQSPATAQTHFTEIEQILLADDDPEFWIASQVAVPETDKPPMHPPPNTSPAPSKQQHHGAAKHRTPRCSPHSHQPRRSPRGTANQTPRGTSAHDHTRKLANQPGRVAVPANRRPGGTDGPAGGASWGHRDGGRESGRQGNEHNSVKRRRMESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XP35</accession>
    <name>A0A8B7XP35_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chloride intracellular channel protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel CLIC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081826.1">
        <property type="nucleotide sequence ID" value="XM_022226134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XP35"/>
    <dbReference type="GeneID" id="110974472"/>
    <dbReference type="KEGG" id="aplc:110974472"/>
    <dbReference type="OMA" id="DEYLMRP"/>
    <dbReference type="OrthoDB" id="1935530at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053823">
        <property type="entry name" value="CLIC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920:SF5">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL CLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43920">
        <property type="entry name" value="CHLORIDE INTRACELLULAR CHANNEL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22441">
        <property type="entry name" value="CLIC-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="148"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022081826.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35780" checksum="9B7BE8722A118753" modified="2022-01-19" version="1">MAEDSNYDEQGINEVAEEDMEAPTSPDMNDENATSGLSETDQADAGAGGDDSAEPAEPEEAPPTEEVKVVKVLKPEDQIRLYVWAGSDLKCLGDDVHCQQIYMTLSLKSEVNEMARFQVITENINIKKSQEFDKLAVNKLPCLVDPVGDRVISDVQTIVDYLEQVFKEPCLIPKKTSLTQVGIDLYRKFTGYLKNTNPNREAEMKNALDRELEKLNKALKESGHRFLDGDKLTQPDLRILPKLHHVVVAGKMFKGYEIPDEDKYGRLKEYLENWKQEPVYQETKYSDADLEYGWFKTRGLDRMYLKIKGGYRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XP61</accession>
    <name>A0A8B7XP61_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Aminopeptidase-2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110974485</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081851.1">
        <property type="nucleotide sequence ID" value="XM_022226159.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974485"/>
    <dbReference type="KEGG" id="aplc:110974485"/>
    <dbReference type="OMA" id="IALKYDC"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF294">
        <property type="entry name" value="THYROTROPIN-RELEASING HORMONE-DEGRADING ECTOENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="24" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="22">
        <location>
            <begin position="58"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="20">
        <location>
            <begin position="283"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="21">
        <location>
            <begin position="601"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="22">
        <location>
            <begin position="956"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="20">
        <location>
            <begin position="1182"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="21">
        <location>
            <begin position="1503"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="18">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022081851.1"/>
        </source>
    </evidence>
    <sequence length="1840" mass="211227" checksum="E3555A4E3118425F" modified="2022-01-19" version="1">MADVSVKKQSVIFLYWTILLIYVSFGLSCGMLLNYEKRDADFVKQQWEYIRLPETIRPISYDLMVRTDLTYSHFTGSVGVLVECLEATDLILIHSKDLVITEGKTTLTRQGNGADAPKLAKDTWLYAINQFAVIELNGKLEKGARYRLYLEFEGPLKNDLLGYYKMSYKTASREEKYLASTFFDPVDARKAFPCFDEPNLKATFSITLEHQPQYHALSNMPKSRPDEILEDGWIRATFEETVVMPTYIVCYAISEFRAKFKYTSNGVRFGVWAREDVIDQVDYALDKGVAILEHFDLLYGQENKYSLPKLDMIALPDFMISAMENWGLNTYKEKTVLYKEGETSEKQKQRILTLISHELAHQWFGNLVTTKWWNSIWLNEGFASYIEYIGANAVEPDWQMWDKFILYDLHPAMATDELVTSRPIITDALTPSENIMMFDKITYLKGSCILRLMNHFLGEPTFTKGLQYYLSALQYSNAGNSDLWFYLDKAVKEDNIDLGEELNVATIMDTWTLQMGFPFIKVERTYNGARQITARVEQQRFLSDPDSDPSTDHPDLGYKWYVPVTYTTASSPDFDSPRSMWLKPQDEFGTLQLSGGSDDDWLLVNINQRGMYRVNYDDKNWQLIKMQLKTHHLMIPSASRAALISDVFSLARAGEVSHPTALDMTSYLKGERDYVPWYAVDHAVAFIKRNIRRRGAYNNFKKYMLNHITPMYEYTGWNDEGDHLKRLSRGLAISMACGYGNLDCQQTSVNLYAEWMANKDHSFIHPDVQATVFCTAIAQGGKDEWFFAFEHYQNPNTSTSMKSTLQTALACSDKPWILRTYLDSILNSSIIRIQDGAAVLQAVAGNPVGLPLAWDFFQANWDFLRASYGDTVFVLDSLISKLTFGFNTEFELQMVKQFIADHLDLGSGARVFTEAVAVIESNIRWIDQYYKEVAGWLKEAVMDPWERIRLPDAVLPISYDLKVRTDLTNFVFNGSVNILMECSEMTDVILIHSRDLTILTDTTTLKREDGETAPGFKIPPWLYQYQDFLVIELDSLLEVGIKYRLHVEFNGTLADDWSGYYWDSYTLKSNETRYKYLASTFLTHTSARKAFPCFDEPDMKATFNITLEYEPQYHALANMPMKGSPETLDGGWMRATFEESVIMSTYLVCYIVSDFKAKFMTTQNGVELGVWAPEDSINETDYALQKGVEILDYFDNLFGLDNKYPLPKLDMIALPELNVGAMENWGLITYHEEYLLYEEGVSSAKQKERVCTFVSHEIAHQWFGNLVTVKWWDDIWLSEGFTSWLEFVGAAYVEPDWKLWDKFVAYDSGRAMEIDAKTTSRPVISKVHQEDDLINVFHFIAYMKGSSLVRMANHFVGQDTFLKGLKAYLRELQYRNAENSDMWYHMNEAIMEDRVDLGDGITDIATVMDTWTNQMGFPVVTITRTYSGEANKITASATQKRFLTDPSSDTTSLYPDLGYTWHVPLTYTSGGNPNFVNPEIQWMRPEDQITELVLDSVGGNETWLLVNINQTGFYIVNYDERNWALLSAQLQTDHTAISVPTRSALIYDAFNLARVGELSQTIALDLTSYLDKEQDFAPWFLVKQSLDYVSENLALENANENFMEYVRNKVTPAYEYIGWDDKGGYDAKLARVEIIGVACKFGNQDCVSRASRLYADWMMTNKTNTMIDSRLQEIIFCTAIAAGGQREWDAAYTAYTDPDVESSLWNVLENALGCSQSETVLETYLHKVLNTSLMSPYDGQYVISAVSGNPLGRTMAWELVAAKWDFFKTVYGLQVVRMVTSDLNTRAELEKVKKFQMEHYAEGRDVFDAFNKAISVIKNNIRWMDQNYNKVAKWLEKTLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPT1</accession>
    <name>A0A8B7XPT1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-fucose protein O-fucosyltransferase 1</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peptide-O-fucosyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110975041</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 65 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022082828.1">
        <property type="nucleotide sequence ID" value="XM_022227136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XPT1"/>
    <dbReference type="GeneID" id="110975041"/>
    <dbReference type="KEGG" id="aplc:110975041"/>
    <dbReference type="OMA" id="SPQCHEK"/>
    <dbReference type="OrthoDB" id="10050276at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11302">
        <property type="entry name" value="O-FucT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039922">
        <property type="entry name" value="POFUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21420:SF9">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034427114" description="GDP-fucose protein O-fucosyltransferase 1" evidence="17">
        <location>
            <begin position="26"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022082828.1"/>
        </source>
    </evidence>
    <sequence length="442" mass="49494" checksum="E1F7D7EF1F3EBFEC" modified="2022-01-19" version="1">MGVFWGNWGVVSIVVLVANTDAAEGSINSPQDNLNLAGDGQFCDAAAQPCPGQRLHRSKGAGVRGAGEGEFDWAGQDEELAHDHVTKDGWDGNGYITFCPCMGNFGNQIEQYLGAIALAKVVNRTLILPPFYHVYHRARQLQNVPFTDLFQLGALRQFHRVIPVHDFLTILAPEHWPAGQRRGYAYPFGGECSLTQSKYFYKDLNPPVVFDDCVPCKLRFDVNFSADERAKGAIKNLWSNSFSPQSHPVLAFNGPIGIFPMIAGNRYLQKYLRWADTAYFAVAQVYISETFGKDIWVAIHLRNGEDWVKACKTDLSTLAYMMASPQCHEKKIGAVTKDLCLPSIPHMLELTLQVFQDVKAKHLFIATDKHPHLQEFRMLLHPLGVSVHHLNPDIPQVDLMILGQADFFIGTCTSSFTSFVKRERDANGKPSIFWGQEYKGFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ63</accession>
    <name>A0A8B7XQ63_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Coiled-coil domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110974763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082317.1">
        <property type="nucleotide sequence ID" value="XM_022226625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ63"/>
    <dbReference type="GeneID" id="110974763"/>
    <dbReference type="KEGG" id="aplc:110974763"/>
    <dbReference type="OMA" id="FYDDIQC"/>
    <dbReference type="OrthoDB" id="6282214at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11551">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11551:SF13">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034908876" evidence="4">
        <location>
            <begin position="22"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="5">
        <location>
            <begin position="416"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022082317.1"/>
        </source>
    </evidence>
    <sequence length="564" mass="62850" checksum="7DFB49F50FAAC09A" modified="2022-01-19" version="1">MECLRGFHVLLFCTAFFIVSSAPVGEPEAKLSKRHDLTSDKEELLEKIKDLENELQGRRSSQVPGDDSPVWAAEHRKKEVGGMSTREWNLEESLLKRGSKSEVDKDDEDSSKEALKRFLDREFESGKFVDHPFSNGKQGQTPGDAANKFDKDDLMAMLDDVSIDDLKKLLSTFEQHKRDYDSGDQDDDGEDDNSGDKKEGQVGDGETEDGDDDGNESGEVEGFLQGISVEELKELIEIIQQKKQDGELTAEDMGKVVYYLMTHLTTEDLQVMLDALRAKNQEEDEGDEMTDEELGQAIKDLVSHISTDQLKRILLAIRARKQELDASSEEPTESVSSEDGLSDRELKPHLSEEEVMQALMNFLAGLSDEDLQNTILAVKRKKTAMKHAVGDVAGEYLQGDKDEDDDDDDDDTSDDLGPCAEEKQDILDKIEDARLANKHSVVGEVPNCDGNGFYAPKQCSGSICYCVDKHGTVTKGEATLWEAASLVCSQENDNPADTSSDESDDSEKESSSLDSTDEEDDDDNGDEEADDEEEAKLEQVERDLLDMLKEQKRHQMTKNEGLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ95</accession>
    <name>A0A8B7XQ95_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Prospero homeobox protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14 15 16 17 18 19 20 21 22" type="primary">LOC110975141</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022082991.1">
        <property type="nucleotide sequence ID" value="XM_022227299.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082992.1">
        <property type="nucleotide sequence ID" value="XM_022227300.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082993.1">
        <property type="nucleotide sequence ID" value="XM_022227301.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082994.1">
        <property type="nucleotide sequence ID" value="XM_022227302.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082995.1">
        <property type="nucleotide sequence ID" value="XM_022227303.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082996.1">
        <property type="nucleotide sequence ID" value="XM_022227304.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082998.1">
        <property type="nucleotide sequence ID" value="XM_022227306.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082999.1">
        <property type="nucleotide sequence ID" value="XM_022227307.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083000.1">
        <property type="nucleotide sequence ID" value="XM_022227308.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083001.1">
        <property type="nucleotide sequence ID" value="XM_022227309.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083002.1">
        <property type="nucleotide sequence ID" value="XM_022227310.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083003.1">
        <property type="nucleotide sequence ID" value="XM_022227311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ95"/>
    <dbReference type="GeneID" id="110975141"/>
    <dbReference type="KEGG" id="aplc:110975141"/>
    <dbReference type="OMA" id="IHEREMT"/>
    <dbReference type="OrthoDB" id="10038576at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.500:FF:000001">
        <property type="entry name" value="Prospero homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.500">
        <property type="entry name" value="Homeo-prospero domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023082">
        <property type="entry name" value="Homeo_prospero_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037131">
        <property type="entry name" value="Homeo_prospero_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039350">
        <property type="entry name" value="Prospero_homeodomain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198:SF0">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12198">
        <property type="entry name" value="HOMEOBOX PROTEIN PROSPERO/PROX-1/CEH-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05044">
        <property type="entry name" value="HPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51818">
        <property type="entry name" value="HOMEO_PROSPERO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Prospero" evidence="9">
        <location>
            <begin position="571"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022082991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022082992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022082993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022082994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022082995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022082996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022082998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022082999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022083000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022083001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022083002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022083003.1"/>
        </source>
    </evidence>
    <sequence length="729" mass="81692" checksum="0B3B77B18680CE54" modified="2022-01-19" version="1">MSTEVDDYNSRMSKRRRVDVGVPRGTHAHHSNKNSASVTNGGGFEVDNSDVLRTLLKNSKKVQNGSTTPPSENSSNSPLIMSQLLQAKAKEIEDLDTSVGRNDENSENEGTDLSSDELETMDGSANDASAIPDNNSAKRVKCNGNSSISTGSMSPGNMSPGNLSPDGEVSPNPLKEDSVKAKRARVENIITSMRQSPSCPQSSQGSSFALEVSRPKRKQAQPQQQKMSEEDSSAVKQVRRQERRRLKYLLSHLQQQLDVLQEKYFDLYEEDNSSLSDASDDLDDLNEPIDTMTAIRKCEMTQAKRASQPVHRRGLNGTIPRESHQKLRNSLKQQLTNAMSTTVDSVIDRFTEVEERRVVNNNNNNTKPRSSHPKSTLSETSNSVLQQAARTASLIVPMPNKRSNPSQSQHSQAPVHQSNSHEQTEAMSLVVPKRGHGKEEALPRTSQADEMKQDHMMPTMLPTSVAIPNPSLHPSFTSIMMTPPSFTSMSESKDVLLEDLRYAHSPQLGHHHHHSQQSSMMNHGSDAGDHPINDSLSYPFIKSDDNDSLIRGSPGLSDLSGYSAANGTSLTSTLTPTHLRKAKLMFFYVRYPSSALLRQYFPDVKFNRHNTSQMIKWFSNFREFYYIQMEKFARQAISDGVEKSEDLLVIRDMELFRSLNMHYNKSNEFKVPESFMEVATTTLREFFEAIRLGKDTEPSWKKTIYKVIGKLDEPLPDFFKSANCLEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR26</accession>
    <name>A0A8B7XR26_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="3">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110974851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022082451.1">
        <property type="nucleotide sequence ID" value="XM_022226759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR26"/>
    <dbReference type="GeneID" id="110974851"/>
    <dbReference type="KEGG" id="aplc:110974851"/>
    <dbReference type="OMA" id="CTFALMT"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00202"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000046">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF80">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022082451.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="39131" checksum="6987C6CE60B60D98" modified="2022-01-19" version="1">MKKRPCATILIRLIEGYIYSRLANHSCESAAHAINSLEGGVGTLVFSSGMGAITTTLLALLKTGDHVIAPYPLYSTTYTMMKRTLSNYGIDVTFIEAGNIEDYKKAIKPNTKIFYGETPNNPCLGILDLKAFADVARLVPTAVSVVDSTFASPYLQRPLELGVDIVIHSCTKYLGGHSDIVAGCMSTKDEEILSGICEFQRETGSCLSPFDAFLLLRGVRTLPLRMEKHSQNGMKIAQYLEQHPKIGKVYYPGLPSHPQHEVAKKQMSAFGGMIAFEVADGLEAAKTLVESVKLINLAVSLGSTESLIEHPATMTHGPFQMRPEDRRKGGISDGLIRLSVGIENVDDLIRDLEQALAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR95</accession>
    <name>A0A8B7XR95_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP-2 complex subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110974887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082511.1">
        <property type="nucleotide sequence ID" value="XM_022226819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR95"/>
    <dbReference type="GeneID" id="110974887"/>
    <dbReference type="KEGG" id="aplc:110974887"/>
    <dbReference type="OMA" id="PVLMHRY"/>
    <dbReference type="OrthoDB" id="413467at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000020">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000004">
        <property type="entry name" value="AP-2 complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017104">
        <property type="entry name" value="AP2_complex_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003164">
        <property type="entry name" value="Clathrin_a-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02296">
        <property type="entry name" value="Alpha_adaptin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037091">
        <property type="entry name" value="AP2_complex_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="3 7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="10">
        <location>
            <begin position="699"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022082511.1"/>
        </source>
    </evidence>
    <sequence length="947" mass="104667" checksum="C967541E0550A571" modified="2022-01-19" version="1">MPTVKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNENSDLMQLVIQNIKNDMSSRTPIHINLALHCIANIGSKAMAETLGPEVPKLLVSGDTIDEVKQSAALCLLRLYRTDSHCIPSGEYHSRIIHLLNDQHMGVVTAATSLIHDLVLDNPEDYKGCVSLAVSRLSRIVTSSYTDLQDYTYYFVPAPWLSVKLLRLLQCYGPPDDPANRGRLNECLETILNKAQEPPKSKKVQHSNSKNAVLFEAINLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCLLASSEFSREAVKKHQETVVTALKTERDVSVRQRAVDLLYAMCDRTNTEEIVGEMLDYLEKADYSIREEMVLKVAILAEKFAVDYTWYVDTILNLIRIAGDFVSEEVWYRVIQIVINREDVQGYAAKMVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPQVQFHLLHSKFHLCSAPTRGLLLSTYVKFINLFPEIKQTIQDVLKNDNQLRNADAELQQRAVEYLSLSVRTSSDVLAPSTASPVQLPQAQPPPAAVPPSTDLLGLDAAPVAQPASAFGMGMAMAMPVAPAAAINSLAAQPAAAQNTLLDIFDAPPQMPAAVPSTAAADTGALSPGAEENFLKFICKNNGVLFENDLLQIGVKSESKSMYCRLVLFFGNKTSMQFSDFSSTVTSPDDLASRLVVKAPPVNSIIDGGAQVQQIITAECVQEFTVAPLLNIRFVLQQTGSQSPASNPDSSSGGSMQYINLKVPIMMSKFFQPTTMSSADFFTRWNQLNAPAHEYQNIFKANFPMDRDGNKTKLMGFGIGLLEGVDPNPDNFVCAGIIHSRSAQIGVLLRLEPNKAALMYRLTLRSSKDDVSKELGRLLSSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XS73</accession>
    <name>A0A8B7XS73_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110975152</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022083042.1">
        <property type="nucleotide sequence ID" value="XM_022227350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XS73"/>
    <dbReference type="GeneID" id="110975152"/>
    <dbReference type="KEGG" id="aplc:110975152"/>
    <dbReference type="OMA" id="YLTPQNQ"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12059">
        <property type="entry name" value="SH3_MLK1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14061">
        <property type="entry name" value="STKc_MLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000076">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000085">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035779">
        <property type="entry name" value="MLK1-3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF293">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 13" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="34"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="116"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="466"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="601"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="679"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="766"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="912"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="684"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="793"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="879"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="988"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022083042.1"/>
        </source>
    </evidence>
    <sequence length="1048" mass="117487" checksum="09809B40A1A4C08B" modified="2022-01-19" version="1">MSPVGDETFLDTMDPLQSVPESPGASKQRESKENGTSLCTAIYDYEATADDELTLRRGDLVEVISKEISVSGDDGWWTGKVRDKEGIFPSNYVSQPHVLLQKEKNFGITEINFDEIVLSEVIGVGGFGKVYRGICGAEEVAVKAARTDTDQDISEIMDNVRQEAKLFSLLSHPNIITLKGACLVEPNICLVMEYARGGALNRVLSNNCKKLGLPPDVLVDWAYQIAEGMHYLHSDAPIPLIHRDLKSSNILINEKIVDNDFYGKTLKITDFGLAREMYRTTRMSAAGTYAWMAPEVIKSSLFSKGSDVWSYGVLLWELLTGEVPYKGIDGLAVAYGVAVQKLTLPIPSTCPEPFVRILDECWNPEPHQRPSFSEILNHLREIADSPFIDTPHESFRSMQQDWKQEIQEMFDEIRLKEKELRTREEELMRQTIEQQCHARVLRQREQELAEREIDLLGRELNIMILQQQQDDKPMPKKRRNKFRRGKVRRSNKRISGPSDFQHKLTVRTDPSYDRRDPRSPLSPEDSPPKSPLPRLRVIALPKGIKGKTWGPSSVQQKMKDRPFKAYSMSEATGKKFTNTSTPSLGYPQWYNTIGNASHDEAEWPTDLGLPKAHWPSVGPSTDDGESTDDSRTSPRNSLKRERKRTTASLYTMTAMLASVAVGFDIRTLNQFRQDELDFRHRKNSSASESYSRQGSLSFQHDLDDSPSMSQASTVRLISVTSTNDDHKHYLRQGSWQGFVDSTSNLTIKQNPAYNEETKAMAPVEPVQAATKTHRRTASADNNLSYLSHKRTPSDSSSPSYSSFTSTVKYDGTDPWSSPESDVSRLPNPPQAPPRRISLVLPSDTHPERPRTLDISPRPRPYSRAYLTPQPGTQDSPLGASPAAAATATPKHSTYTSDVSLSSVTLSPAHHYQAAGGAEMPRPTATPSPAHYYSPHHQGASELSRSPAHHYLPPHANPSHTPQHHQSPHPHVGGQTPSHAAQHYTSPQHQHHTPLHTPHHQPRSLEQRTSLLDEDVVGQKADDTMPLVREGQENKPRKLSVLELEEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSG6</accession>
    <name>A0A8B7XSG6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Ropporin-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC110975541</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ropporin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083802.1">
        <property type="nucleotide sequence ID" value="XM_022228110.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083803.1">
        <property type="nucleotide sequence ID" value="XM_022228111.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083804.1">
        <property type="nucleotide sequence ID" value="XM_022228112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSG6"/>
    <dbReference type="GeneID" id="110975541"/>
    <dbReference type="KEGG" id="aplc:110975541"/>
    <dbReference type="OMA" id="QWSSAYF"/>
    <dbReference type="OrthoDB" id="10067602at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd23019">
        <property type="entry name" value="DD_ROP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.890.10:FF:000004">
        <property type="entry name" value="ropporin-1-like protein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047844">
        <property type="entry name" value="ROP_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952:SF9">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14952">
        <property type="entry name" value="ROPPORIN-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022083802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022083803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022083804.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24958" checksum="A4615ACF7CDE747A" modified="2022-01-19" version="1">MPAVGDDVPMYCSQQINIPPDLPDILKQFTKAAIRTQPNDVLQWSSAYFHALAKGETPPVKERLEMPIATQKTDTGLTPGILSVLNRQLGPKKVLKLSDLEQKWKDNCLPNERLYSLLQLGSFGDDIEWLKFFALACSALAGNITSAMKVICEILTRDPEGGAARIPFDLFKELYTYLAQIDGEISEEQTESVFTYLQYHVDKQNGLVQPRNFLNPDCPKLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XT22</accession>
    <name>A0A8B7XT22_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14" type="primary">LOC110975203</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022083149.1">
        <property type="nucleotide sequence ID" value="XM_022227457.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083150.1">
        <property type="nucleotide sequence ID" value="XM_022227458.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083151.1">
        <property type="nucleotide sequence ID" value="XM_022227459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XT22"/>
    <dbReference type="GeneID" id="110975203"/>
    <dbReference type="KEGG" id="aplc:110975203"/>
    <dbReference type="OMA" id="SAVPKWC"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000009">
        <property type="entry name" value="Rieske Fe-S domain containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054716">
        <property type="entry name" value="Sol_Rieske_ferrdox_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22543">
        <property type="entry name" value="Rieske_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022083149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022083150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022083151.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="18583" checksum="E570B3C13B28726C" modified="2022-01-19" version="1">MEASAQDPTSASSASSEWVAIATEVELQEIGRKTALVSNRKITVFYRDRRFYAMDFHCYHAGGPLDVGNIEDINGISCIVCPWHKYKISLETGEGFYQSIDLKNPRRAPCWKSKGIKQRTHSVEVREGMVYVRLSTSDTKYESDYYYSKDYQQRMNFVKGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW63</accession>
    <name>A0A8B7XW63_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mucin-5AC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084086.1">
        <property type="nucleotide sequence ID" value="XM_022228394.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975694"/>
    <dbReference type="KEGG" id="aplc:110975694"/>
    <dbReference type="OMA" id="RRDEQPM"/>
    <dbReference type="OrthoDB" id="10072609at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1606"/>
            <end position="1622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084086.1"/>
        </source>
    </evidence>
    <sequence length="1752" mass="186068" checksum="15A17245053BD662" modified="2022-01-19" version="1">MAASVAESPGQPPGNRASECQSSSKLTSLEASENSITENGRASIQEKQTKEKQPSPTLCSPSKSKRKLDSSDGHDDSTCDPQLETLCRKKFKPIAPKPTVKKDHHQSVVTATVPIKDAPQPDFGPSFCVTKGDSKSGPVMFVSPKVQLIPSVPIIAHTPMFNTEALASSGSPFSVTVPLMSRGKYLNVMNPPARIAMTDIAGHYKTVVQLLPSSSSHSCLQPTSCVPTKSNLNKTSADISSANAAPVRSEQSQGRNGMSANRTAKTKTVSKPKASRYKYSLLMNGGCYDGNLNTAANTKPQTCITPAVSLNGGVRFNLPAILTSSGILQITVPSVGIANGQVQYCDVPSAADVVQTQSSNLQTPSTQSVNASDIVATSTGQPVSTANACITTTSSGLTQSSVSESSARLGSVAQISCKKTNATSTRGVSLDETLRIMLRSPRTNISHDNQRETSQKKKSKPHRMSASSAKSRCKGQKTRVDVSVASSVSENSSIQDKSSGRSGIVEALPGQCTDEVSSHPVDSIHRTVPSEYLSEQRNNEVTTTGQSVQYRQGDAGENGLTEQISLGQDVIPNQRSQGIRASSYLVNEETMTIVHPATTTVVANSASHDSSKRLPDTLVSSSGASDSCSSITNGLGGMTNVQDLDYLRHSTLPVNVTTSNNLHGSVRPVNEQWTRTITTAPRASSLPNFATGPRGFYTSTTIAPLVTFNISQTANHQVPQGPKDSAPVPTTVSFQPGLALLTSSTAPSMQSKQTNNITVVTTACVSLSKSLTSIPRLNSRTVFSTTMCSSVVSRNLHSHVQMNSASQGSHDGIHPGTSVQSLQNPSETIRPQGNVPSSSHPVARQQRPHADSHTAVTYSHNTVTSVGNANHSFPSTLISSSNSCISTTTLSTPPAPHGTYLLDVNTPRIPPASLSSISDERNAVPVRRQPQLPGDNLGTMHPEINGAIGNRGHNPPQNDLPLVIARQANQEHLVPRQNVDASGARPSSLQCTTLTNRPEHSLCTPSLPVVPHHAGILATAILRSRALERNPWGVPSLNMSTPPVVSSVALTPPVTVTPNTTAGFFRATETVSVTNSTISHTHSADHGLHSQSATGMPSSVVRCTDKGIQNWPTTSEGILSRQEGSSLPGTHAARLSTERQGRMAAPPPSFTGSEGADQGVNNSVTTAPGDQVLSMQSHIQSVPLHSNIPPNARNAMNEALQRRNRNLRMHPTRSETPSSVVSTQTHASRVAVSAIQESSSFTGTQPTHAVAERGEMTSTDLLHASREHPRQESVPHQHPAHHVHGMPGARVPSNSMSHLPMPLMPPPSVLYGSSTPVPNLSMTPLHGVPLPGSLSAHSVQGHGMTHQVHATPPPAPHHGQSAGSNPQGPVNHMFVPTPYGPIHRSLYMPPPSPHPPDLSLMSPRSYGQVHMHDSVLYSPRFSSPIRNLPGSSLAEGMFGTAMPRSFSDDRLDTCCSGPYTHSPPIHDNSSHMYPPGFMSPPVSRNQPPSQTSLCDSHQRQFNHRSHQGVSERHPFCHDSIRQAAPQVPVPVTQASSFNGTPSSAIVTTVCISLDSNVLVCTASSCVPTQQSSLGNSLPANSLSPTTSSTAGVTPGTMVSSSASENTSAVPSAPTSSSSTTPVRVVNLGNTSDKYLPLELVVSSPSTPVTSSASVATLPMQLSSEQIVKFGDVILECSRQILRESGRTVLCCWSCDYHTAEPKKMYRHQRRDEQPMKCQLCSHMGISRCQLNQHFKEMHMDKDEDPFRTPAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWN3</accession>
    <name>A0A8B7XWN3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110976384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085284.1">
        <property type="nucleotide sequence ID" value="XM_022229592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWN3"/>
    <dbReference type="GeneID" id="110976384"/>
    <dbReference type="KEGG" id="aplc:110976384"/>
    <dbReference type="OMA" id="EPDVECR"/>
    <dbReference type="OrthoDB" id="5948003at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085284.1"/>
        </source>
    </evidence>
    <sequence length="243" mass="27244" checksum="4D7F91E197E8FFE3" modified="2022-01-19" version="1">MKHSEHGWSKCDVSCGIGYQSRRVLCLEPDVECRGEESVEVRRCLGIDCENPEQLESKIACSGASFLIIGIIVGIFLVLVTIGGAYIFKNFLLPKIKEVNKKSSLKQKNKKRPPEPLPRSKGKVDDEEHLYEDVDGIQGKKATAKNSYVIMTSKSDKEKKRFGSSKKKQENHKMAESEGSDQGYVDPADINQPRSEELEIGRLRDPPPPPGTKDKKPSKSKTENGVSSQEYEKVDENEYLEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYM1</accession>
    <name>A0A8B7XYM1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110976412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. MFSD6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085352.1">
        <property type="nucleotide sequence ID" value="XM_022229660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYM1"/>
    <dbReference type="GeneID" id="110976412"/>
    <dbReference type="KEGG" id="aplc:110976412"/>
    <dbReference type="OMA" id="WVVVIEI"/>
    <dbReference type="OrthoDB" id="515887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051717">
        <property type="entry name" value="MFS_MFSD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily associated" evidence="8">
        <location>
            <begin position="80"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022085352.1"/>
        </source>
    </evidence>
    <sequence length="628" mass="68659" checksum="AD774B7F8388203F" modified="2022-01-19" version="1">MADLEPSSEKRERILQALDQASQQGASSQEEQDGKATKPAARTEGRKKDSNWGSGTGESTPFWELVWDCFHVNAMVLENKLIYFMLSAGTAGVLPFLSTHGLTWGLPPWHFGLAVGAGLLVAFVFVPVWGFAADKLRWHRGMLWAVVLLWMAFTILAVYLPYQPKPAPCEVAQGLLLETLDVSCEGDDFNSPESSERRHSSFGYLGHYPVVLETWPEPCTVDIGQVCSSFNDSEVMPRLTSLTNSSVPDWEVGTKDSSPPPNFTKVEAPSLSERTPVTPEVQEAPGGVLRQTHLGWLYDQAMLHRASLVVFILAAAGCAAQISSFSLADAAALMSLGEAQRDRYGWQRCFGTLGFALSFVVVSVFLNESRQTKLSCGVTWEQTDYFLGVVVFAGFMTIGTLLASCLRFKHNDMSSQHTLGHVTGVIFSRKFSTVFVTAFFLSFCSSAVRTFLSWHLHELGGTSILLGAAILVFTLADILTSFCTVWIVKKAGYHIPLVVGIVGYCLVYLSYALLSRPGWVVVIEIIHGASYAVTLNTMTSFLASSVALVSQASVQGLLNGIYWGLGPAAGTALFGFLVDVIGPTLSFYILTLVCVVYGLVFLVWNRNELPLIDRYLPGEYQPVNQDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYU9</accession>
    <name>A0A8B7XYU9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110976332</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085210.1">
        <property type="nucleotide sequence ID" value="XM_022229518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYU9"/>
    <dbReference type="GeneID" id="110976332"/>
    <dbReference type="KEGG" id="aplc:110976332"/>
    <dbReference type="OMA" id="RYYLMRG"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45153">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45153:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="521"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="562"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085210.1"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118343" checksum="FCF03F4C8C288439" modified="2022-01-19" version="1">MEGSEKMSGGSQEEATTETSHSNPVPSKVENLPEETVDQVNTSPGLEDQVQTLTDPDDKVSSKTGEKPSDKDTVTPENNGSSQSSEQEQRSSPPNQMDSSKLDSPTVRTDCPTEGDQDGTTVEEGEVEHEGSASPERTEKSLDNSSPVVEDVGNNGRIRWTVRLNVEADVANNASIQRNDASQTQLNSSNQAALEEGVIEHSNSTSLPVAVPASDPTEAEQENGTAQGVDEKCPPVSIPTPELDRRISVSEVVKETSNSVTPSKPGTPETGISVNTKGDLGLQSRLTTPHPPSRTHPDRPQTEASGSTEFTYDEKKDFRTPDYEYAQTPLFSVRGDSALRQERRTVSRGDSTKSVTFADDLMGRKSAKDYEVEEGDEEAGDSTRDAGDDETRMPEAGKGETASTVEGETAADGAGEELPEEKESAETAAADLFPTAVSEEKIEEAKQRRKERAASDAALKEQRLVGLFGAPRLEEKHSMEDVVGSRAREHFDKGCVCLSELQYGQAVVCFDKAINLCSKEVRYYLMRGEAYLQLCDFQSAILNFKKACVLAPDNDAYYSRLAFVYYFQGQTLFDQCLFAEALESFSRASEMRPEIVGYHTRSVACLAALQRHGECLALVNKRLEVEQNNPDLYIMRARLHELFRNTSLCYYDLKDAIALDPGQAEASALMRQLEARAEENRNHAVRLQLQGKLKEAVHKITEAVETNPAVADYHLLRGALHRRLHDYNAAIDDFLLALDKTDHNEQSRVYLEAQRQLLLTYNDFAVECFLGGHFEEAIILLNKAIKGEKREKGLYINRLDCFFRLNELHFALADYHQALELDNGDWTIRSRIASIHSEFGLLDYEEHSYKEAEARFTVAIQHNPRVGSFYIYRAKVRYMLENHPGARHDLLVTLHLEPNNEEILSLLPRLFPGKTIAEIMRSKAGRQAKAEVENAVVTASPVRLPALTGDAASRGEQLSSPPQAKAPAGAAAKQVAFAPAAATPRDSVMPDLKACMDEIGFNTVLAKKKKKISSHVKSLLHDRQSLWTDAPKLCPQPPARPYEVRGGNPNKNQSNIDPAMGWRSFSVGVGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0H9</accession>
    <name>A0A8B7Y0H9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110976765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZFPL1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086022.1">
        <property type="nucleotide sequence ID" value="XM_022230330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0H9"/>
    <dbReference type="GeneID" id="110976765"/>
    <dbReference type="KEGG" id="aplc:110976765"/>
    <dbReference type="CTD" id="7542"/>
    <dbReference type="OMA" id="CEHCMVA"/>
    <dbReference type="OrthoDB" id="1916590at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16487">
        <property type="entry name" value="mRING-H2-C3DHC3_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058730">
        <property type="entry name" value="U-box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039043">
        <property type="entry name" value="ZFPL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058731">
        <property type="entry name" value="Znf-B_box_ZFPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12981:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25998">
        <property type="entry name" value="U-box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25993">
        <property type="entry name" value="zf-B_box_ZFPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022086022.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37099" checksum="6F4B7AE970EBF7E4" modified="2022-01-19" version="1">MGLCKCPKRKVTNLFCFEHRVNVCEHCLVANHPKCIVKSYLQWLQDSDYDVRCSLCEKELAEGDVVRLICYDVFHWACLDEYARQLPSHTAPAGYTCPSCNNGIFPPSNMVSPVAENLRENLSRVNWARAGLGLSLIDEPQRPAQRLEEPTEELYKSTESSVSDPTPSSSITEIDSAVYRPTTTTGVQARTTSTSVINIDSTTPLLKPEALPSTGQLQTAHKRQGGNRDDEIVDIIQDHDVDKYKRRSALHWFSMWFKTRTGKRSADASTPMRRYAILLILGVIAFFTIVVIMTQAGRASANADPFLDPMANPNIRVGRKILELSHFRLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y218</accession>
    <name>A0A8B7Y218_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="8">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110977417</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GcvP family.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022087218.1">
        <property type="nucleotide sequence ID" value="XM_022231526.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087219.1">
        <property type="nucleotide sequence ID" value="XM_022231527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y218"/>
    <dbReference type="GeneID" id="110977417"/>
    <dbReference type="KEGG" id="aplc:110977417"/>
    <dbReference type="CTD" id="2731"/>
    <dbReference type="OMA" id="RNLICTC"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000025">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000007">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001696">
        <property type="entry name" value="PRK00451.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="9">
        <location>
            <begin position="93"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="862"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022087218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022087219.1"/>
        </source>
    </evidence>
    <sequence length="1042" mass="115543" checksum="1BE1E866357F43C2" modified="2022-01-19" version="1">MFRLGRLGHARALTLAERPKRTAFSNITKQKYSSLVSKTSVPSTCVLGCTNTRHPRWAQQMEVYRCQQNCSQSTDSESRKLDRVYKRHDYFPDRHIGPNDADISEMLSFIGAESLDGLIEQTVPSSIRIQRPLDLDKAMTEPEIIGRLQQIADQNQLWRSYIGMGYYNCWVPTTIQRNILENPGWTTQYTPYQPEISQGRLQNLLNYQTMVADMTGLDIANSSLLDEGTAAAEAMTLCGRHTKRMKFFVDQKCHPQTIAIVKTRARPLGIEVQVVDRGEADFTGGDIAGILFQYPDTDGNIDDHHDLVEAAHSHGALAACATDLLALTLIKSPGEIGVDIAVGNSQRFGVPLGYGGPHAAFFAVRDKLKRQIPGRLVGVTRDVQNKPAYRLALQTREQHIRRDKATSNICTAQALLANMSAMYAIYHGPKELRHIATRVHNATHILAEGIKRTDHTIETGEFFFDTLKIRCAGDKNDMVQRAADKKINFRLYEDGAVGVSMDETVEEKDLNDLLEIFGCEATAADIADSFPGDQPPGSITETRHSRTTPYLEHPIFNTYHSETSLVRFMKILENKDLSLAHSMIPLGSCTMKLNSTTQMMPVSWPKFCNLHPFVPLSQAEGYKVLLEELEHDLCEITGYDNICFQPNSGAQGEYTGLMVIMAYLASKGEGHRKVCLIPMSAHGTNPASASLAGMTVKPIKVLANGSIDFEDLKKQVNTHKDDLAATMITYPSTNGIFEEGILDMCQLIHESGGQVYVDGANMNAQVGICRPGDYGGDVSHLNLHKTFCIPHGGGGPGMGPIGVKKHLAPFFPTNPITPPSSTTQPGAVPLGAISAAPWGSTSILPISWAYLKMMGLQGLQKASEVAILNANYMMKRLEGPYKILYKGHKGFIAHEFIVDTREFKQTCGVEAADIAKRLQDFGFHAPTMSWPVANTLMVEPTESEDKDELDRFCDAMLYIREEIDEIIDGRISLEQSPLKNAPHSQSIVMANHWPWPYTREQAAFPMPFVKPETKFWPSVGRIDDVYGDQNLVTSAPPMESYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6A6</accession>
    <name>A0A8B7Y6A6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospholipase A2</fullName>
            <ecNumber evidence="8">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110977466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="5">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022087336.1">
        <property type="nucleotide sequence ID" value="XM_022231644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6A6"/>
    <dbReference type="GeneID" id="110977466"/>
    <dbReference type="KEGG" id="aplc:110977466"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF51">
        <property type="entry name" value="PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034379443" description="Phospholipase A2" evidence="8">
        <location>
            <begin position="25"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="9">
        <location>
            <begin position="40"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="85"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="92"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022087336.1"/>
        </source>
    </evidence>
    <sequence length="175" mass="19219" checksum="D055B9D4B8941EA5" modified="2022-01-19" version="1">MDKLFVVVLFVCFSSTRLISVADGVPVNERAEQGTITANAFYQLGELAVCTTGLNLIEGGLAYNHYGCYCGLGGAGTPLDATDTCCYVHDNCYTHSPCSINVFQYSIPYKKSVSSCGTADATITCKKASDYPWYYGSEKDCAEAICNCDKDLAYCFRETRSTYNEAYRNWSNSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6C2</accession>
    <name>A0A8B7Y6C2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Muscarinic acetylcholine receptor gar-3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110978238</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088752.1">
        <property type="nucleotide sequence ID" value="XM_022233060.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088759.1">
        <property type="nucleotide sequence ID" value="XM_022233067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6C2"/>
    <dbReference type="GeneID" id="110978238"/>
    <dbReference type="KEGG" id="aplc:110978238"/>
    <dbReference type="OMA" id="RETLHCG"/>
    <dbReference type="OrthoDB" id="5964776at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF9">
        <property type="entry name" value="LEUCOKININ RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="71"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022088752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022088759.1"/>
        </source>
    </evidence>
    <sequence length="641" mass="70962" checksum="4A483715A096C136" modified="2022-01-19" version="1">MPLPRMNRDLTSKIPHGLRNSLNRSAPVKELTSANMDSNSSASHVDYYSKHPVKDILIATFVPVFIVSLIGNLLVVYVIVRNRSMHTVTNFFLLNLAVSDLLVTLFCIIPTLLYFIQVNWSLGVFICKAHKATLTVTTTASIFMLTVISMERYIVILHPFHTKRILTVQRLIGVVVAVWLLSIVLSIPMCISYDVLPGYVEGMYCGATAEYIENGARIQFIAMLFVCYLVPLVIMLVLYTRIGWGLWTPSRTGDNSLSALPGPSGKKSKTYMKVTYKGNKAVSSVEEKSPVPPGEGLRIHIGRQISPPPGESTSAHSDSDDTPRKTLLRNCSSEPSRPINRGDVQEKIGPFFIDYPEETDIEQTETVESNNTAVLWRSCNDILLCSGGDKSASTRYEARGIETEKTGIDSNGIGSHQAMSKSENELNSHQITDEGNQSAPSGDGRGIADTDKENSQYLNPGRTYGGFKSRLGSKSEGDKRPANRKYEPAAASGQASPAYGRANPHALSRQCMKKTPSKRKRNAEAVMHARRKVIRLLVVMVVCFAVCLFPLQLISVWSLFAIFSDQSEGGALVTAFTYLAYFSNSAINPFLYAFLSDNFRSKMRETLLCISSRTRRQVSLRQMRLKSVTSDAFTESELMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7T7</accession>
    <name>A0A8B7Y7T7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short-chain dehydrogenase/reductase family 42E member 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110978532</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089288.1">
        <property type="nucleotide sequence ID" value="XM_022233596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7T7"/>
    <dbReference type="GeneID" id="110978532"/>
    <dbReference type="KEGG" id="aplc:110978532"/>
    <dbReference type="OMA" id="MKIGGSH"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022089288.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="46936" checksum="5C21EFD94C22A4FB" modified="2022-01-19" version="1">MLIPHSEIMTTETTWIGPERHKERVMDLLRTLDVPSLREKKVLVTGGGGFFGIHLARALHMLGCTVVITDKATPIEKYNEEIKFVQGDIRDRKLMEELCKGINCVFHIASFGMSGAEMMKKRDFIESINVGGTENVIEACVKLNVTRLIYTSTINVVLGTREFDMATEGELQRIPPEKHTDDYSRTKTIAEMLVLDSNGRKTQSGEVLHTSAIRPPGIYGAGEQRHFSRLMGFIKFYKANAGSPYSKTNWVHVDNLVNGHLLAAEGLSAGKKHVAAGQAYFITDETPINNCVFFKPVFTGLGYTFPDFWIPLNVIWWLAFISEIMHFLLKPFYDFVGFTRTEVYQLALHHTVSYQKAQQQLGYQPVPRGLEDSVAHLRQLGYGRALQETSQTSWTSSLLFKVVLSISIIVVFIAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7Y9</accession>
    <name>A0A8B7Y7Y9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-phase kinase-associated protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110977762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087876.1">
        <property type="nucleotide sequence ID" value="XM_022232184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7Y9"/>
    <dbReference type="GeneID" id="110977762"/>
    <dbReference type="KEGG" id="aplc:110977762"/>
    <dbReference type="CTD" id="6502"/>
    <dbReference type="OMA" id="CDFTADH"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22149">
        <property type="entry name" value="F-box_DmSKP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="144"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022087876.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="55948" checksum="8F382214F3ECEA1F" modified="2022-01-19" version="1">MLKCRTRSRTAPGLVSASSRPRAKPNRKNEVQAVKKRSKSGSKQLQEFITPTFTWDIPKVDKQAIYNDLGVKEMDTGGAVDGKQLLLGKRANNKRIKKPATVPSRADKVKGHLVSPNQFKSQQAHIHNGRYCSCKKQLDLEDLSDPFCRLSDEIMLGIFWWLPMTTLARCARVCRRWYHLVFDDSLWRRIDISNKTFASGILGQILQRGTVAAKISRCSIHGPVFDAVLTESPAKITRSASKASKLSKCHVESALRQSLHLKYIDLTATDARPEQLVEILDRCPGNQIKKLSLESCRVSDEVMKSIAKHGRSLKELNLCMCSGLKEAGLRAVLRNCTKLQSLNLGWANLSRKEIDVFMEYVPKSLEKLNLSGYRQTLRTVDVVLLTCRCPDMKELDLSDAAVIDFAAIESITESMTQLQHIALSRCYSLPRLSFVQLGMLKHLRALDVFGLVQESGMLESMQELLPGVKINSYPFSAIARPTTTNKHNIIWEIMCYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8I1</accession>
    <name>A0A8B7Y8I1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sodium-coupled monocarboxylate transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110977859</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088056.1">
        <property type="nucleotide sequence ID" value="XM_022232364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8I1"/>
    <dbReference type="GeneID" id="110977859"/>
    <dbReference type="KEGG" id="aplc:110977859"/>
    <dbReference type="OMA" id="MTIYMAC"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="528"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="628"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022088056.1"/>
        </source>
    </evidence>
    <sequence length="653" mass="71675" checksum="07F6F497F8DFAD1B" modified="2022-01-19" version="1">MAVDDTQRLFQVWDYVVFGLMLAVSVFIGIYYGCTGGKQKTTKEFLLADRNMNPIPVAMSLVASFISAITVLGTPAETYIYGTMFWLFGFAYILTGIAVTRLFLPVFYRLGVTSANEYLEKRFNKVVRVAGTLTYFLQMVLYMGIVIYAPALAFNAVTNLSLWGSVVAIGVACTFYTTVGGMKAVLWTDAFQMCVMMAGFLAVIIEGSLRLGGFIQVWKIAEEGGRIDFWNFSPDPSIRHTFWSVVVGGCFTWTATYGVNQSQVQRYLTVGNLRRSRISLYLATVGMVIVVSCACSAGLVMYSYYANQRCDPYTSNQIDQTDQLIPIFVMELFGGLPGLPGLFTSSVFSAALSTVSSGLNSLAAVTAEDLVRPCFKKMQEERYTLVTKGIAMGFGLLSLLVAYIVSLLNKGVLQLALSLFGMTGGPLMGVFSLGMFFPWSNSKGALTGLICGLAMAFWVGIGAQIYPPEVYKPPLVIDGCYSTNATNSTFGGMGSTAMSGFTTMPPTEEPRPAIAALYTLSYSWYSCTYWLITVVVGLLVSFLTGANKSSDNDPMLYQHIADACYCCLPEVIKKPMRCGQDKLEYEDDDDTKDTAYCVKEVDGVKTSQDFQMNDYNGVGTITNMKYIPKPDNPEENTYDNPVEVYSEQPATEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y965</accession>
    <name>A0A8B7Y965_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110978804</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110978804</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022089779.1">
        <property type="nucleotide sequence ID" value="XM_022234087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y965"/>
    <dbReference type="GeneID" id="110978804"/>
    <dbReference type="KEGG" id="aplc:110978804"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025155">
        <property type="entry name" value="WxxW_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13330">
        <property type="entry name" value="Mucin2_WxxW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="WxxW" evidence="6">
        <location>
            <begin position="286"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022089779.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40178" checksum="E4D9BB3CE43B3E22" modified="2022-01-19" version="1">MTSCTSDPGQCPGGQSTWSIWMKLNHADNPGPVTFLSSGTGSNTGVSFSRLLDGNFEVAVNIRSAQWLRSLDDNLIPDGVWFHLVIVIDTTASTQLDVYIDGTQQGVFSSTDGISTTATPTLATPFLTLGGTSGSDGQRDATSAFSDFMIFETKLTTTKIKNLHECGVVVNPRETQIKEVWNILQLEVSNPNELGYRCVLQSMERPGGGDVAWHLYLHGNNKIPLGDRTMSNYGACFYKSDLLINKYNDLVQRGCTSNCQIMCEFKSSAQLYQTRNIAEADLIYEWTPWLSSSSPQDNPVGDNETITHLLQVYPVDGCAYPVRIECRERYTMKTPEYLRDREVDGMVDNGSGLEETRREFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9H8</accession>
    <name>A0A8B7Y9H8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Ankyrin repeat and SOCS box protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9 10 11 12" type="primary">LOC110978373</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089011.1">
        <property type="nucleotide sequence ID" value="XM_022233319.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089012.1">
        <property type="nucleotide sequence ID" value="XM_022233320.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089013.1">
        <property type="nucleotide sequence ID" value="XM_022233321.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089014.1">
        <property type="nucleotide sequence ID" value="XM_022233322.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089015.1">
        <property type="nucleotide sequence ID" value="XM_022233323.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089016.1">
        <property type="nucleotide sequence ID" value="XM_022233324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9H8"/>
    <dbReference type="GeneID" id="110978373"/>
    <dbReference type="KEGG" id="aplc:110978373"/>
    <dbReference type="OMA" id="CPRINAN"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03716">
        <property type="entry name" value="SOCS_ASB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF15">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00253">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="5">
        <location>
            <begin position="484"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022089011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022089012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022089013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022089014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022089015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022089016.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="58820" checksum="E58608C81BB4E6A0" modified="2022-01-19" version="1">MDFTEAYPDRCSTVGAAVRMGNAEVLQELIARGASINVHDNRGWSPLHEAASTRKYDCVRILLTKLSKEDVNARTWEGETATFFAAKTGHLKILRLLVKHGGDPNISNNEDGSPILQAVSGNHKDCVAFLLRQGANVNSHLFGGWSLLHEAACCGFPDILSLLLRAGAKIDVRDDFGIMPVFTAAQYGKLDCLKLLIEHGADPNARAEDNATPLYLAAQEGYSQCVEYLLIHGAVVDIPTNTAQGFRPIHVAAFRGHLKSLKLLIPPSLSVLEQVKIPGEWEELLTPLQLAARGGHDEAIKMLLDAGCDPDCGVRNPTENTKGMLLQMAQTLDIDPPPFYCATQMGHYTTAALLLESGASVCRPSDQYCLLTMFRDDTRATELLLDHCGKIDCKHILSDLFHMLFPLDALRLLMDRGLRIRFNCQAAHGLCPRINANILTLHASEVTCVMKLIYGYVDRLCLCEHNIKRLQELGCYDKVVSLTSKPHSLLHLCRVAITEHLGTTRAPKIIPTIDFLPVLIKDFLLYKDMRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9X1</accession>
    <name>A0A8B7Y9X1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sugar phosphate exchanger 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Solute carrier family 37 member 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14 15 16" type="primary">LOC110978099</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088495.1">
        <property type="nucleotide sequence ID" value="XM_022232803.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088496.1">
        <property type="nucleotide sequence ID" value="XM_022232804.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088497.1">
        <property type="nucleotide sequence ID" value="XM_022232805.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088498.1">
        <property type="nucleotide sequence ID" value="XM_022232806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9X1"/>
    <dbReference type="GeneID" id="110978099"/>
    <dbReference type="KEGG" id="aplc:110978099"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061513">
        <property type="term" value="F:glucose 6-phosphate:phosphate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000028">
        <property type="entry name" value="Sugar phosphate exchanger 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000849">
        <property type="entry name" value="Sugar_P_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF12">
        <property type="entry name" value="SUGAR PHOSPHATE EXCHANGER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002808">
        <property type="entry name" value="Hexose_phosphate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="28"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022088495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022088496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022088497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022088498.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="56846" checksum="895F48851B6C0293" modified="2022-01-19" version="1">MAGTPLMTPLLNACFRGRYRTLLHKILVLIITFFTYMTYHLSRRPISIAKGVWHRNCSIPINDLQFPVFNISDAGNPNWCDWKPFDTSDAEVLLGWLDTGYLFAYAVGMFFSGHIAERMSLRYFLFGGMFLSGFFTAVVGLAQFFQIHNYAFFITMMIVGGFFQATGWPAVVAVVANWYGKGKRGLIMGVWNTHTSLGNILGAVIAGAFVDYYWAWSFIVPGGIIASMGVIVFLFLIEYPTDVGCDPPKNQEEETKSVGVNFSDDENGHFGERKVLSEQPAITTWRALMIPGVIEFSLSLFFCKLVSYTFLFWLPYYISRTTKLSDEQSAYFSTLFDVGGVLGGIVIGLLSDLSGASATVSFVALVVSAPLVYIYNAYGYLSLAKSIGLMMLTAFFTNAPYALITTAVSADLGTHPTLHGNAKALATVSAIIDGTGTIGAAIGPLLTGIISPTNSHGWSDVFLMLAGAEVASALCLLRLVFKEMKKACCQSDYQLISGTGPRAEGEVGVHTYPTEVPFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YB48</accession>
    <name>A0A8B7YB48_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Condensin complex subunit 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979177</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090448.1">
        <property type="nucleotide sequence ID" value="XM_022234756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YB48"/>
    <dbReference type="GeneID" id="110979177"/>
    <dbReference type="KEGG" id="aplc:110979177"/>
    <dbReference type="OMA" id="WIGRNCM"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="7">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022090448.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="33142" checksum="F2D4B86E09B165B1" modified="2022-01-19" version="1">MSARIWIGRNCMVKCRVIQIALSRYVFAFIQKDRQAEALVEKLCHRFRATRTDRQPQDLAFCLSLLNMSEKCVRRLQENLACYADKLHDAEVYACFASILSKAKKFSKPETKVMVEDFEQKLAECHDKGVDDAAAADKASKASAAAKARDNGSRSAKKRNTKRRGRGKSSLDSEDEEEEDNQATTTPAPSSRKPSHRGRQTTEQKTQGTAGKGRRVRAVTFSSDEEDSDELFGAGERENKAKDSAFDPAEEKGSSDTENRDPTPTPRGKGKTRKLHNPRGTPKGSPTPLSHQKQVHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBN3</accession>
    <name>A0A8B7YBN3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centrosomal protein kizuna</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Polo-like kinase 1 substrate 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110978421</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kizuna family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089106.1">
        <property type="nucleotide sequence ID" value="XM_022233414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBN3"/>
    <dbReference type="GeneID" id="110978421"/>
    <dbReference type="KEGG" id="aplc:110978421"/>
    <dbReference type="OMA" id="WGEESDM"/>
    <dbReference type="OrthoDB" id="8015657at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026742">
        <property type="entry name" value="Centrosomal_kizuma"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16299">
        <property type="entry name" value="CENTROSOMAL PROTEIN KIZUNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16299:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN KIZUNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="372"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="804"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="890"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="968"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022089106.1"/>
        </source>
    </evidence>
    <sequence length="1060" mass="115940" checksum="4B158E6474B6F9DC" modified="2022-01-19" version="1">MATDNVEFYERMQKLQAVQQQREKQRLSLEQEFNSYLKSDRRLNNVRASKLQSYWAKVCEDERRSRARNEQLLREYERVEAHVAALSARTDRLRLIKDQYEKQIEMMYPRWQEQVELKRRQQLLQQQHDQQQLAQRLQELHQRQSQQGQPQQHQAQAQRQSAQHYPAQQQLSAQQQQLHVQSEPQQQVPLAEQQQLWHSQSQHPSSQLIQRVDLNDYHHLRRTSPLLANLHTQVNMPPGRTPEDPCYASIQFGTQPLGLADKVPSLGHVQPASPQIVGSSDSYEVPSAFSDSHLKMQNGLPGYGQEQASGVTAGQVGIVGMGSGLQAPPVSSDGGYMKLHGQTGGLEASPSAVQPRSSSVYAEVQDGRISGSTLQVRATPKLQPHSVTDAAEAQGTKAASAVVPRGKMRLEPTAAVQGGADPRGRPTPQESPEDDNDSIVTPLDDDDSYLEPSAARQTGGKTQPTSREGLKLAERASSAVSAKAASTARTDPFTSEEDGEDDEDSTEKEALRDVLQRQLNLQEDAEGDKRSTQVATAAGVAQSRRKLQQEGIEQQGELTGKPNGAEQPKQLQETGVQDEQDDKEYSGTDSEIGSDVSLPLSDTAEGPGPGRSEKPSGKAPTASMAAQDSRLQPKVTTVTMTQHGFWRLVSAVEHEIEDSDNIEKIYNYPECTKAIKMEIVKTADGNGNLDRLDPNAISMVVLDQVEQIVLSMAGGCLLSDKLLDTKRTITEATIRSFLYSSALSFWDKLLQHLVLLIRKGVMDAEEVASLVAPRLIAKGSTLANKAFDVLATILQNLEEEESQLDDTYSTLPSASATPSHLDTPHHNEIGDRPRAPPEVPPLDLGESSHLETPDLETNRVSHDSFFDEPAVPLTETKAYQQLTQSSQCLTTAGQDSGKGDGEIEEGDKELSGGDGDDEDDEIERATRLTPETPPSSRNKKRRNVLSSFGGSGSLGLSYGDDGDDKDTGGGAGNEGGETGRSEQVSDLISSPSPSPSPKGSGYVPSGMEQSLKSTGRSDPMQRSAAFWGEESDMEESEMSVPMGTGTLKSDDLKDDFDFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCA9</accession>
    <name>A0A8B7YCA9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110978947 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110978947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090000.1">
        <property type="nucleotide sequence ID" value="XM_022234308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCA9"/>
    <dbReference type="GeneID" id="110978947"/>
    <dbReference type="KEGG" id="aplc:110978947"/>
    <dbReference type="OrthoDB" id="10013007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13157">
        <property type="entry name" value="PTB_tensin-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00173">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832:SF2">
        <property type="entry name" value="SH2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15832">
        <property type="entry name" value="SHC (SRC HOMOLOGY DOMAIN C-TERMINAL) ADAPTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="94"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="5">
        <location>
            <begin position="821"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="640"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="924"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="925"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022090000.1"/>
        </source>
    </evidence>
    <sequence length="955" mass="104496" checksum="4797885BEB35FA7D" modified="2022-01-19" version="1">MYNGRGNRVAAEDQEERRPVLSGKKRSSYLDKRTRLLSDASSSSSHSSEPDPDSIAGMRLRGSLVPSPGGPRSGAPGAGGQDCGDFADEWSTKGVTKACEYVGSFSVAHLQPNNRAEFVRLQLQSLQNPKKSRPVSLFISLSGIKVYDPENHQVTLMAHALKRISYATCDPDFCQFAFLSRNPKGPVGIQYCHVFITREPSEAEEINAIVGKAFKVAYASLRSKKQFFELIEELNREQEEYFAQITHQQNVVTRVGSWIDGRERELVVGQGRVWAKQVAGRKQHKQPHIIAGIDPALQVTIPPPNHCRSPVNFSASSQSQRPSSSQAQMGASASRNARINSAESGDSAEEFEWVTEEDIEEGEVQPSAPTMEAEDLNNRKRMSHVAFKQTQRTVALPPAPYYEVEPCNEWTARSIALPTTGFSIIHEQKTKHLVLQKDQAAASSSGSSMALIETHRAHTPGQILLQDSTVPPPFTYKPNKEEDDCYGYGNGYSENRLSEYSDRDSFDYDRSYAILEQFINATCDISGDWLDPDLRPSPVSKEPSERPFDDVQSEGNSEQQDSVSINNNIKKLSDESSVSAPDSVNIPQPIPHRSMQQGDLSTDDVQGQRSSPPINNQSQRLSKLSCQEDQVAHLNGQAMNINQNANEEPGRDKPKPTPRKAKAPAPPIPVDAGKVGHGKGPAPPIPSADVNRLVNVDESSEKNNLKRSASSVSSSGGEAVSRALAAPKSLDIAGAAAVSQRLLKGQASTASQRSGGRSPGHVGHKVEVEIGKFRCKKVSNNGIAPPLPPRSTSLVENGMSQDGSSAHGNPIQYKDVTEAPWFKAGVPREIAVEILQQEERGAFIVRESKSHPGCFALSIKVDGDFNETGIANYLVVRTKNGGYTIKGFGRDFADLPRLVHHYALHQEQLPCKLNLSRCNPLFRQDEDEGEEEGDGDGDLDYTSRTDYKPVMAGMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE84</accession>
    <name>A0A8B7YE84_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Homeobox protein engrailed-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090705.1">
        <property type="nucleotide sequence ID" value="XM_022235013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE84"/>
    <dbReference type="GeneID" id="110979320"/>
    <dbReference type="KEGG" id="aplc:110979320"/>
    <dbReference type="OMA" id="MMARLKI"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090705.1"/>
        </source>
    </evidence>
    <sequence length="327" mass="35231" checksum="A5A08F87F4427D51" modified="2022-01-19" version="1">MEVGLMNGEDSFCSTDANLELLVPTPSPDTSGRESNGSGDLPPPPPAVKTSFSIAEILGSSAQATPPHHSRNHHKLEDRPAEGTADLVTGRSKSPVDTGAHLVRPTAVRETAVPVVTGAAGGGGLPPPGHWCSGPTAAALQYAYGASPGGMPVWSSWCQAAGFGRPNIPGPKPLGRRPRKPGVDRKPRQAYSSKQLERLEDEFKADKYLSVSKRLELSMALNLTETQIKTWFQNRRTKWKKQMMARLKIAQRQGLWTAPFLTPWYSPLGPYSAATAAAYAPYPPPGLAGGLPRRASAKTRRQRRPRPQRRSGSPPWQAGPLAFTAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGS2</accession>
    <name>A0A8B7YGS2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110979393</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090846.1">
        <property type="nucleotide sequence ID" value="XM_022235154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGS2"/>
    <dbReference type="GeneID" id="110979393"/>
    <dbReference type="KEGG" id="aplc:110979393"/>
    <dbReference type="OMA" id="MIAFTIF"/>
    <dbReference type="OrthoDB" id="10463188at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090846.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="16015" checksum="EA4999B75A3194A0" modified="2022-01-19" version="1">MQRHDRVVVGVIIFTFTTVAPIVLGLPVYSEDDVTDLGSKDVPVRLRHKGATFLLNGGPNSRGQKPNGTNAPAMPRYGSLRIRRSPDDDYAYKDDKHEDYYEGGGAQEVGGGRKRMIAFTIFFIWVCWVIIACSILRIVAKNMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH26</accession>
    <name>A0A8B7YH26_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110979972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110979972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091887.1">
        <property type="nucleotide sequence ID" value="XM_022236195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH26"/>
    <dbReference type="GeneID" id="110979972"/>
    <dbReference type="KEGG" id="aplc:110979972"/>
    <dbReference type="OMA" id="EQAAYWK"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022091887.1"/>
        </source>
    </evidence>
    <sequence length="160" mass="17511" checksum="F5F8BE75CD6B18EC" modified="2022-01-19" version="1">MAGKIKVAESSGSDVVLACIQSFGGIFPSDHGFLRRVAWVESKDGTDPNTYRAGYHGGIWQVDKIGFESTKDTASHPGLRNKFASIKSSLSIDWTTVQWDDLRKPLYSALAARLFLANIPSPIPSGLQEQAAYWKNHYNTSSGAGSESKFVNDVKTLENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHC6</accession>
    <name>A0A8B7YHC6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription elongation factor, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092649.1">
        <property type="nucleotide sequence ID" value="XM_022236957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHC6"/>
    <dbReference type="GeneID" id="110980352"/>
    <dbReference type="KEGG" id="aplc:110980352"/>
    <dbReference type="OrthoDB" id="5949570at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006392">
        <property type="term" value="P:transcription elongation by mitochondrial RNA polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.280">
        <property type="entry name" value="AF1531-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039150">
        <property type="entry name" value="TEFM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21053">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21053:SF2">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12836">
        <property type="entry name" value="HHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092649.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40506" checksum="B75E5A320A4EE4DD" modified="2022-01-19" version="1">MSVVKFWCRFSFSAQASWPRLVRSLCQEASKEGESLTDNSPRIQREETLSQKKDTSDLVSRSASDEDPTKIIQLINTVSERDLAAIKHVSSNVAASIVSHRESSGPFAEVRDLLKVPGIGRQTLQRICREILKPSLHVNIGNNQGPTTEGDQFGVAASRIESLKDIVAVDIGLKHLSWVYMTRDRQVWQWRVKDIVGIKAGKWDPPTYHKMITNAIAEMPKPDLYVLEHQSYTNANKGTFQMLLYQRTLQSMLYTALNHNRDDIGTPRAISVPQTQVGRHFGLQVRGTRMSGRDIVATLLRDGMERGESDDDLPARMSWEDAETFQAATKHEKEHLANCLLLAIAFYDQTVDKIESRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YI59</accession>
    <name>A0A8B7YI59_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Uncharacterized protein LOC110979630</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17 18 19 20" type="primary">LOC110979630</name>
    </gene>
    <organism evidence="14 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091308.1">
        <property type="nucleotide sequence ID" value="XM_022235616.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091309.1">
        <property type="nucleotide sequence ID" value="XM_022235617.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091310.1">
        <property type="nucleotide sequence ID" value="XM_022235618.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091311.1">
        <property type="nucleotide sequence ID" value="XM_022235619.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091312.1">
        <property type="nucleotide sequence ID" value="XM_022235620.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091313.1">
        <property type="nucleotide sequence ID" value="XM_022235621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YI59"/>
    <dbReference type="GeneID" id="110979630"/>
    <dbReference type="KEGG" id="aplc:110979630"/>
    <dbReference type="OMA" id="HHAKESA"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06916">
        <property type="entry name" value="NR_DBD_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000030">
        <property type="entry name" value="Nuclear Hormone Receptor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45805:SF2">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR HR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="122"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="624"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="516"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022091308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022091309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022091310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022091311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022091312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022091313.1"/>
        </source>
    </evidence>
    <sequence length="851" mass="93102" checksum="6A27D60F15207D35" modified="2022-01-19" version="1">MEDELVTTTTSESLVSMPSSSVRDTCTKSPKVSSSCRQVMCAVCGDQATGRYFGAQICEACKSFFIRSTKKGMPNFKCQSSGTCDVTPTSRLLCQYCRFQKCLVAGMCRKVKQPSKDPPPDNTPCKVCGDTSSGIHFGVFTCEGCKGFFRRSLKDGASYVCGDNKKCIITPTSRNVCRYCRYQKCLQVGMSRQSIKLGRHHKLDMDISESCSEMSEVSQQLNAVSAGGCCPNNAFDSEETVMEVKSTSPPPEVSGVSEPMAVPGEFDKGFGDGSSHLMDFKSGQPVSQSPPMPMVTSQMSTAFVGGGLGCENKQKLGNAGFPKNVPILGRHPHPRVCPQLPVGSLEPLGSLPTSNVPSSTVICSIQHPSVSLVQSTPDGNAFSPMPSGGSGFPFGHNFFDGQLHPAAATSLPGHGASGSQSMPTAAAFRFGISQSHSPSLSLQARGDHEMSNKECTESLLATSPGRPIMNVDACQPLNPHQDNMGKPFAMMDTDSGAAPSLRIKEEPSSCYAEEAFKRQRDPETMSKVSTPNPSRVAGKHALSDDSEDESDEQLPSAKIAPAAQMLQQEQEEGTSSSLAYAKKIARRLELGCLQGEILSEENELKLNRTSQPVQKFERVLITVEMTQAFEELALLFQTMFNSKPQIEATEELRTKMDKASPESMRLFQESISLKIIGSVTFAKNIPGFRHISVNDQMNLIKAGTFPCILCQLCWQGCMFSWFDDTFFTVPSLIKLVCGMKTSCYSFREDFTKLTFDQEEIALFTALIFINPDNPGLDDVEFILGLHGKLRQVFKHYCLEKYGELKQYLKFISFLPRLYQIELLHKKSIKEGYSQQPSPDVTLPALFAEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKS0</accession>
    <name>A0A8B7YKS0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Alpha-2,8-sialyltransferase 8E-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110980538</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093020.1">
        <property type="nucleotide sequence ID" value="XM_022237328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKS0"/>
    <dbReference type="GeneID" id="110980538"/>
    <dbReference type="KEGG" id="aplc:110980538"/>
    <dbReference type="OMA" id="MRFYMAG"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23963">
        <property type="entry name" value="GT29_ST8SIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF36">
        <property type="entry name" value="SIA-ALPHA-2,3-GAL-BETA-1,4-GLCNAC-R:ALPHA 2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="78"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022093020.1"/>
        </source>
    </evidence>
    <sequence length="289" mass="32613" checksum="A51EB48AD1B87849" modified="2022-01-19" version="1">MKQDWKPDVAKTREFRADIRTELGKAGSPGNFLLTKNNTSPRAKMRFYMAGKARNMTPSLWSYLPQNAIFKQGQFASCSVVGSSGILRGSRCGKKIDQSQFVSRFNLAAVWGYETDVGSQTNFTTLNPSFVANKLNGLKTQTNCSHFGNILKQFKDSKLWLPMFGASVYFSTLKRTMVTATEFQSVQPVLGHPDHFLSVSKLWRKTIGNNRLWPTTGLYLVLSLVDVCDRINVFGFWPYSTTINGSDVPYHYHNDVTGKKNLHSFDTEFKTLVNLYEKGIINMHFGACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMA1</accession>
    <name>A0A8B7YMA1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidative stress-responsive serine-rich protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Oxidative stress-responsive protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Peroxide-inducible transcript 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110980320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092596.1">
        <property type="nucleotide sequence ID" value="XM_022236904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMA1"/>
    <dbReference type="GeneID" id="110980320"/>
    <dbReference type="KEGG" id="aplc:110980320"/>
    <dbReference type="OMA" id="RFTHDIS"/>
    <dbReference type="OrthoDB" id="10045817at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008494">
        <property type="entry name" value="DUF776"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31383">
        <property type="entry name" value="OXIDATIVE STRESS-RESPONSE SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31383:SF2">
        <property type="entry name" value="OXIDATIVE STRESS-RESPONSIVE SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092596.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="39814" checksum="587103E90E550ADD" modified="2022-01-19" version="1">MADENVEDDQLQVMFKKLRVDPAWSSVGSVSLLVPHTEYPVDKPTKARKTGLRRTSLRSVKHKFEPYSTSCCSLGNNFGDSLGATDKGKCKTAICLCSNKTDQKKAEKESEAQTTQDNLKEQETSSFPEELTSACCTRPLICFEAFPLPALPKKSSNWKDKEVFGASSSKLKPLSSFKTLATIEEETVEATAAASSHEWLSETCESVLLPCRCSTASQQCKPSTKPLRRLTRHRKAKLEGRLQSYGSRTFATYRDSARQLIKLGPPSSVQKHAPSAKSPGKPSALKPDLPHQAWTQNLLAINNNNATSSPPRSEFSCSQQARFTPDISFDDTTADDLAGYFENLVHIPKKMSEMAEMMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN73</accession>
    <name>A0A8B7YN73_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase-like protein 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093900.1">
        <property type="nucleotide sequence ID" value="XM_022238208.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7YN73"/>
    <dbReference type="GeneID" id="110981042"/>
    <dbReference type="KEGG" id="aplc:110981042"/>
    <dbReference type="OMA" id="ICVGTMT"/>
    <dbReference type="OrthoDB" id="2019266at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093900.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24962" checksum="B406CB9C4F93A372" modified="2022-01-19" version="1">MAANCDKRSPAEILESYRAEAQIFASNESVADFYNSWARRYDQDTLGGGYKAPVEFAAIAAELIDDKSSRILDAASGTGLIGQELKRVGFTCIDALDPSQASLDQSKEHQSYSEYICDRLDGHKTKIPDNHYNAVLIAAAFGVPGHVDESSFPELIRITNPGGYIMFTVSEKVLEQIEERMEVAIGAHSQQGRWEIVGYRWIQYILNEKLDEKSKVPILRVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YV50</accession>
    <name>A0A8B7YV50_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MOB kinase activator 3B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096360.1">
        <property type="nucleotide sequence ID" value="XM_022240668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YV50"/>
    <dbReference type="GeneID" id="110982337"/>
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    <dbReference type="OrthoDB" id="8170117at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096360.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="25024" checksum="A1286F31FD50E0AD" modified="2022-01-19" version="1">MDLKGLFGGKERTFRPKKKFEPGTLRYQLHKKAMASLNSGLDLKAVVSLPAEEDLNDWLAVHVVDFFNRINLIYGTICEYCTNESCPIMSGGPKYEYMWCDGEKFKKPTALPANQYITHLMEWVETLINKESVFPVNVDVPFPKNFVATCKNILKRLHRVFVHVYIHHFENLVAIGAEAHINTCYKHFFYFVKEFNLIDPKELEPLKEMTEKICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVK4</accession>
    <name>A0A8B7YVK4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein 6-interacting protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096722.1">
        <property type="nucleotide sequence ID" value="XM_022241030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVK4"/>
    <dbReference type="GeneID" id="110982550"/>
    <dbReference type="KEGG" id="aplc:110982550"/>
    <dbReference type="OMA" id="ILVVQWI"/>
    <dbReference type="OrthoDB" id="10070125at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029383">
        <property type="entry name" value="ARL6IP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28640">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28640:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15062">
        <property type="entry name" value="ARL6IP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096722.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28494" checksum="0B99B9BB4D55FDCC" modified="2022-01-19" version="1">MNGTKSIEASAEEGSPTKKKMPRKRRNKKDPVVQKLNFDKECEETTTIGGSFESDRISEGGASVEHEIWGCVPSPEAGGPPTASEQSGYAELIPTDFAHRDRFRFSWPYGLTEDDDSPNRFLVMCACLIVLILVVQWIKTEGYTLCLRWYMELLDNEELGNSEEMGTLSFFSLFSGISGFLWSLLVSFLLGLSCLLFSWSLTYQDSLRPGEFPPSPLSPKKFRKRSGHSFHSSYVMAIINGIAVFALSAWWLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVR0</accession>
    <name>A0A8B7YVR0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13" type="primary">LOC110982918</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022097397.1">
        <property type="nucleotide sequence ID" value="XM_022241705.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097398.1">
        <property type="nucleotide sequence ID" value="XM_022241706.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097399.1">
        <property type="nucleotide sequence ID" value="XM_022241707.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097400.1">
        <property type="nucleotide sequence ID" value="XM_022241708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVR0"/>
    <dbReference type="GeneID" id="110982918"/>
    <dbReference type="KEGG" id="aplc:110982918"/>
    <dbReference type="OMA" id="GNGTKHD"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000128">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044519725" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="27"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022097397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022097399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022097400.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="66321" checksum="45FE208D6BCC0D2F" modified="2022-01-19" version="1">MEGSCATRRMTFACAILICLAHGRASNPVVQAIQGRIVGTRLEFSPIDPKLRRSVDAYLGIPYAEPPVGLLRFKPPVAKSLRGELQATKLGNRCPQPPFNFGLMTVKGTFNEDCLFLDVFVPHRAPPKAAVLVFLHGGGFFLGAGTIERTPPTPIAAVGDVIVVTLNYRLGALGFLSTDDDIIPGNMGLLDQRLALEWVRDNIQAFGGDPERVTIVGESAGAASVSFHLLSPGSAGLFHAAIMESGDATVSWATVRADEARKRAFALGKIVGCHRDTSWQLLECLQKVTDFNIFVEKQHERLHQELNRSDILTSFVPVVDGKFLLSDPDDVYAEGPINDAAIIIGGNADERMLKVASFFPDHTDEPPFVDSASYDALAQVTLRQISAEPIVAEAIKLLYRNASCAADAPKCDYLQTLSQVLGDITYSCPIDKAARAFARAGRKVYRYYMTHAPTTPLVGNKWTGATHLDDLLFVFGLPLISSEEYAFTSEEARMSLWVIKYWTNLAKTGNPNLSSLDAELTFEETETEWLPFTLQELAYKDLSPAMLNGRGVKAKECLILNEFIPKLAHIAEEAKMCREKMSEHAEMSTKDGGAGSGTCTKETCPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY52</accession>
    <name>A0A8B7YY52_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110983045</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097617.1">
        <property type="nucleotide sequence ID" value="XM_022241925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY52"/>
    <dbReference type="GeneID" id="110983045"/>
    <dbReference type="KEGG" id="aplc:110983045"/>
    <dbReference type="OMA" id="KILWIDM"/>
    <dbReference type="OrthoDB" id="10254111at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37916">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37916:SF2">
        <property type="entry name" value="CHITIN-BINDING TYPE-4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034334892" evidence="1">
        <location>
            <begin position="29"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022097617.1"/>
        </source>
    </evidence>
    <sequence length="543" mass="60631" checksum="90C2CB4D1EA4E7D0" modified="2022-01-19" version="1">MEMASAASRTILLLVGVIFGLMPHPTVGHLCIISPHQRGPLDVSHSGSHTCFRHGAPCGGISPQQPLTTYIGGSTIFVTFQQNYNHYEVGYPGYMDIALATSSSPDAHFEIVGVFGDVNEHAQDHQQNYSLPVDLPDIDCSNCVLRGRYVAHKPGERTFYQCSDIIIKSSRAVKATELQRNQVYRPQGHTEPIRPPSVPAAKIPRFLRAGPYAPLLYGFAWDPEKSGSVFVTVNTVTGEKQKISPMYFGLGSGIQYGTPSPMAQSNKYVMDQIACFDREMPYLNLLEHRNGGLDAVPNKLLWIDMVTREIAGEYELDTPNHLPIISLVPYLRQLYLAVQIKEMYPQSENFTFLYGTLSYMGHFEQILNTSQTPEHDYVNYLWATLNYKTKVHYMLIGNENSPDALKAKIYTLNVASKDLTVRQLDVSEYTISAIQVYEKTGELFAMSPGLFGKPYPAWTLVTVDPSTGAIKKKYPVAPAGVFQQYYGGTVFNIDQDSGVLYYVLRIANSRSDVIASVCLDTGKVTFSRLTDLRNIYNLAFYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYB2</accession>
    <name>A0A8B7YYB2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lactosylceramide alpha-2,3-sialyltransferase</fullName>
            <ecNumber evidence="13">2.4.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Ganglioside GM3 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">ST3Gal V</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sialyltransferase 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27 28 29 30 31" type="primary">LOC110982962</name>
    </gene>
    <organism evidence="26 31">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28 29" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1)-Cer (LacCer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM3 (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17950"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60065"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.4.3.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:18418"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a beta-D-Gal-(1&lt;-&gt;1')-ceramide + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1&lt;-&gt;1')-ceramide + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41780"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:82643"/>
            <dbReference type="ChEBI" id="CHEBI:143593"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:41781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ganglioside GA1 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GM1 (d18:1(4E)/18:0) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:73110"/>
            <dbReference type="ChEBI" id="CHEBI:78484"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41785"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ganglioside GA2 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GM2 (d18:1(4E)/18:0) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41776"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78485"/>
            <dbReference type="ChEBI" id="CHEBI:78486"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:41777"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.9" evidence="13"/>
    <dbReference type="RefSeq" id="XP_022097471.1">
        <property type="nucleotide sequence ID" value="XM_022241779.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097472.1">
        <property type="nucleotide sequence ID" value="XM_022241780.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097473.1">
        <property type="nucleotide sequence ID" value="XM_022241781.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097474.1">
        <property type="nucleotide sequence ID" value="XM_022241782.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097475.1">
        <property type="nucleotide sequence ID" value="XM_022241783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYB2"/>
    <dbReference type="GeneID" id="110982962"/>
    <dbReference type="KEGG" id="aplc:110982962"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047291">
        <property type="term" value="F:lactosylceramide alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23967">
        <property type="entry name" value="GT29_ST3GAL3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000006">
        <property type="entry name" value="ST3 beta-galactoside alpha-2,3-sialyltransferase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051142">
        <property type="entry name" value="Glycosyltransferase_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713:SF92">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-BETA-1,4-GALACTOSIDE ALPHA-2,3-SIALYLTRANSFERASE-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13713">
        <property type="entry name" value="SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022097471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022097472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022097473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_022097474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_022097475.1"/>
        </source>
    </evidence>
    <sequence length="461" mass="50931" checksum="B39A85235237A09F" modified="2022-01-19" version="1">MGMTIRLNIRALVYILVIAMVLLMLDLLFMMSLGRHKATIVKSSIDMDEAWLRFDQQNLGLTNSAQGVLQCQRILLTGNHDQLCAGTKPEVDSGPGHTRGNIGGGVKIGGTVAVPINRPLDHSGSGATKPAAKQHQTWAQAARKPKLSPIVQKAVDMSTALASPNVTCIPERSRNRMLNVYGEKFNLSIPPFLNMDFEREPHILDLPFPFGVQDSTKLVKETLGIAWNTSLPFISKSKSCLRCVIVGNGGLIKDTSLGKVIDNFDVVLRINDAPTKGYEKDVGSKTTMRMCYPESAFTKPEQFHGNWLLLLMVFKPMDLTWLQTVAQGKKMTNQKGFWKKIASSVPKKPEDFRILNPSILRETGFDIIGFPVSADGKVGKNVPTSGCLGIMLALRFCDEVAIAGFGYDTSIPNAPLHYYDKLKMKEIKRSWTHSVDKEQKMLFDLVDQGVIQDLTGGLIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYE8</accession>
    <name>A0A8B7YYE8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-ribosomal protein eL40 fusion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097510.1">
        <property type="nucleotide sequence ID" value="XM_022241818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYE8"/>
    <dbReference type="GeneID" id="110982986"/>
    <dbReference type="KEGG" id="aplc:110982986"/>
    <dbReference type="CTD" id="7311"/>
    <dbReference type="OMA" id="CGRCSQL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 13" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022097510.1"/>
        </source>
    </evidence>
    <sequence length="128" mass="14646" checksum="F32C247B88CC86EE" modified="2022-01-19" version="1">MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKILASKYNCDKMICRKCYARLHPRATNCRKKKCGHSNNLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ15</accession>
    <name>A0A8B7YZ15_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flocculation protein FLO11-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096456.1">
        <property type="nucleotide sequence ID" value="XM_022240764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZ15"/>
    <dbReference type="GeneID" id="110982397"/>
    <dbReference type="KEGG" id="aplc:110982397"/>
    <dbReference type="OMA" id="ADYNEND"/>
    <dbReference type="OrthoDB" id="2020426at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096456.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="57426" checksum="AA244B65F5F7D9CD" modified="2022-01-19" version="1">MAYAAHPGGGPWWAKMPLPPGWDAKYDHNTKKYFYIHHTTRSTQWHDPRKAYYEQQQQQQRIGGLAPGPAASPYQRSPQMPQRSAWTPSPGGPAIPLQPIAKPKCKICRTNEVPSANQECQSCQLKARQREAELVRAREEKEAERRKQEAQQRIEKEQERRRVQSAARSRTPVTSDYHETSFGTEPERVELTVGQKRAMIENLDEAFPGIERSVVEMVLETSSWDSGKATTVLMSMTPQKDKKKSTTAPMAKAAAKPQASMAKPSAAASTSPPKQPTAAVKSKMIDNLKKMFPSASETLVELALETTHYNQAKATQVLRMTISSDGKKDAKKSDTKAKTTASTTSTSFSVGTSSVGSSGASTSTTVVAPQPKTSAPASSVSATPVSKPTPSTSLPTPASASRQSTSLPSTPTAPATSRQAKAAARAKGAARRTRSAERAPKQEFHSLYSFKAQGPDAALVHGPDKKNLLDTYVDYMGRDGSIVQGPRKENVAGPGRREGHNASLAVGPQGSHYTGPQANLAKGSMHGANRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0W8</accession>
    <name>A0A8B7Z0W8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TPR and ankyrin repeat-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110983459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098420.1">
        <property type="nucleotide sequence ID" value="XM_022242728.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983459"/>
    <dbReference type="KEGG" id="aplc:110983459"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="1168"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="796"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1232"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1395"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="844"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="896"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="923"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1395"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022098420.1"/>
        </source>
    </evidence>
    <sequence length="1821" mass="208548" checksum="92CD4831B4257D56" modified="2022-01-19" version="1">MIASRREADVHYLRMKHEFQKWARLPGGIWWQVEEFKRQGNAIIHQDPRRAIHIYSMALGIDDDPTHPFNFLTPRERAILYSNRCVAFVKISDLGQAFADAMACIRVDCTFPKGYWRAASVLKQMGREEKALETLITHYPTICGSDGKAFYNRVDFVYEITILTDQLWDKWRESQPLFRHLDVHTSIWTEVVQRLAKNKKYHGLHLVFLQGCTQPGKPYDIGKGGVATGCNTSDLDLQTTVCDLSSANNSWSMPLVLELLKHGSKVEGLSQKEGDTPLHCAVENALKTGWVDLLEYLLSKVFTMSEQRNLPDHFGDSLFHLVAKTTGPYCHAKTVVDVLWKYRVDPSRKDQQGCMPLDVVPMSSPHFTKIHKLLTETAEQFMGQNQQLFQQQKPNCKQEEMMEQMQKEEQLMQERLRKEQERRQQEELEARRQQLLEEQQRQEKEEQEQQKRIQEEKRQKEEERLEKLRRQQEEKKKEIQKKKEEKEMQKKRETEVNLRIYHKGLTFQKQGKHYQAVPLFLEFISKEHKNVVIYQDLNRCKDALVESLEHCQKIPNSIKFKPPRTYWNMMVQELANKSKWWSMFLLLVGQSYRTNQNSKGIAHGCDASGVSIVAFLSQWKGLDMDPDQLTMVKALLKNKAKPDGLLNDAITPLAHCLKTENYELVNLLLTHGASPKLLVMDHGDTPLHSALKIGFKQKDRKFTILELLLTKYSRKPKSTTYLDKNAKDGAGNTLFHLALTCKPQNLSFSAVQILTQHKVNPCIQNNEGMVPLKMVTDKDRRHKYLAEAEKYYNMGSKSVPSVSRGVDQHSSSDGTPAPGVPDNWSKADGESRQQAHHNQSKKARPTEKKSQREKLQEEVEQLISAMPKFIPNEAKKEIRPAAETSVGPDTTLQRTEPQQAEEVPQEVNSKGGKPDERDKDMGSEEEEEDEEMEAIDATIFDNLAWEVECTAKVWKFLHDRQVPNKLKETAIRKIQMLGSGDWRGRLCKPLEGPPKQHNMKLYEARLTKGGRILWEVAIAFSPRCSEESEKRLASVAGGTVYSEIIRIWDIVTDHKKLIHAINVIVKSVERGEECIIRKNLVGFSKKSTTEATMGNRLPTYFHEITNNSSKHSSKPPDNAKKITKPYFPPASSRENEYHIMKFYSVNSTLVNAMLNDNDVKVDFPFCVTELEHAIINLQPRPASSILLLGRSGTGKTTCCLYRMWTKFFKYWQQVSMTGEPLIPRDIAFIHQDKPDEDPDKSAPEPESSSASNITSRAESCSAWCNYSCDSKSGEGPRSSTGDADGKTVMDHLHQIFITKNKVLCREVQRNFCEMSHACEFAAEPLAQQDTPIPDRFQDAHQARFPLFLTPHQFLLILDASLPNPYFPREANGTLKRKIQGWDNEDGLLTSTLLMEEEDEEDEDDASVPPDDEIKAQGLGAGVAYPHRPRKEQQGARCGASGAQYDPRREVTYEVFAFELWPRINKKKLLYHPTLVWMEITSFIKGSVEALHTDSGHLSLESYLALGQKRASNFTANREEIYNLFKTYEHLKSQKGLFDEGDLVFHIYRRLQHVQMLNWVLHEIYVDETQDFTQAELALLIRCAHDPNSLFLTGDTAQSIMRGVAFRFDDLKSLFHYASKSVKALGKHSAVTVPKKVYQLTHNYRSHAGILKLASTIVDLMTHFFPNSFDHLERDQGLFHGPSPVLLESCSFSDLALLLRGSKRKTSKIEFGAHQVILVTNEEAIKRLPAELRLGLVMTICEAKGLEFDDVLLYNFFKDSPAEWRVITGYTNELIDQQRCQSAKQQKGLKEIEVESLTSTSRPRPLKFDPDEHKVRIITGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1U4</accession>
    <name>A0A8B7Z1U4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Parkin coregulated gene protein homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110983638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098750.1">
        <property type="nucleotide sequence ID" value="XM_022243058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1U4"/>
    <dbReference type="GeneID" id="110983638"/>
    <dbReference type="KEGG" id="aplc:110983638"/>
    <dbReference type="OMA" id="INGPIHE"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF2">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022098750.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="27350" checksum="EDCDB3194B0F5D7E" modified="2022-01-19" version="1">MEVARRKTKLTSKRSDDKEIVAEAFTIQSQMKNAKVVCPPKAGAFVEQEGRPTAFRKFYERGDFPIALEHDTKGNKIAWKIEIDKLDYHHYLPLFFDGLKETTHPYEFFARQGVHDLLEHGGSRIVPVIPQLIMPIKEALSLRSRKVLCTTFKVLQQLVISADLAGEALVPYYRQILPILNIFKNMNLNIGDGIDYGQQKRENIGDLIEETLAALEKHGGEDAFINIKYMVPTYESSILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1X2</accession>
    <name>A0A8B7Z1X2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arginine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110984097</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022099608.1">
        <property type="nucleotide sequence ID" value="XM_022243916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1X2"/>
    <dbReference type="GeneID" id="110984097"/>
    <dbReference type="KEGG" id="aplc:110984097"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000016">
        <property type="entry name" value="Arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.70:FF:000002">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000084">
        <property type="entry name" value="arginine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="16">
        <location>
            <begin position="88"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="15">
        <location>
            <begin position="545"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022099608.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="76088" checksum="495891F7F732773F" modified="2022-01-19" version="1">MSEIVTKYTERAAKQEAEIAQLKQEICQLQNGEVMDENDDSSSELNQLRIENQKLKYRLAHLLRSIEEEQKQSATTAGNDTAMTSITQQLEGVFAYAIMAAFPDLVDPTVAVEASKSDRFGDYQCNSAMAIAQQLRALGRKISPNEIAQAIVQNVQLNDVIEKVEIAGPGFINVHIRRPFVSTVISDILTKGVRPPKTDRKKRVIIDMSSPNIAKEMHVGHLRSTIIGESIARLLQFAGHDVQKVSHFGDWGTQFGMLIAHLQDRFPNYLTESPPISDLQAFYKESKVRFDEEPEFKKRAYSLVVRLQAKEPDIYKAWQLICDISYRAFDEIYDRLGIKDLVPYGESFYQDMMVETVQDLESKGFLELDEGRKIMFTDTGTVPLTIVKSDGGFTYDTSDMACLKFRTLTEKADWVLYVVEAGQSVHLENIYAGGRMVGWYDPARVRVEHIKFGVVLGEDKKKFKTRSGDTVRLADLLNEGMKRSLDKLQEKERDKVLTTEELEAAQRSVAYGCVKYADLCHNRINDYVFSFDKMLDDKGNTAVYLLYAYTRIKSIARLAKVDDAAVLQAAATTPIDLTHPKEWKLAKCLSRFPEIVARILNDMLMHTLCEYLYELTTTFTEFYDACYCVEKDRKTGEIVKVNMSRILLCEAAAAVMAKGFYILGIDPVSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z322</accession>
    <name>A0A8B7Z322_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter G family member 20-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984302</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022100023.1">
        <property type="nucleotide sequence ID" value="XM_022244331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z322"/>
    <dbReference type="GeneID" id="110984302"/>
    <dbReference type="KEGG" id="aplc:110984302"/>
    <dbReference type="OMA" id="SRYFIER"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03230">
        <property type="entry name" value="ABC_DR_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047817">
        <property type="entry name" value="ABC2_TM_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038:SF3">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43038">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY H, MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="13"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-2" evidence="9">
        <location>
            <begin position="472"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022100023.1"/>
        </source>
    </evidence>
    <sequence length="702" mass="77718" checksum="A1FEB33190D2DD6B" modified="2022-01-19" version="1">MKMAGDNDSVAAVQCINIKKHYGRGAHRLDVLQNLNMFVPQGSIYGLLGPSGCGKTTLLRCILGRLSMDHGTIWTLGKLPGTIGHGVPGSMVGYMPQETALYEDFTISETLNYFGTIHGMPRDVLQGRKEFLINLLDLPSMDSMIRNLSGGQKRRVSFAAALVQSPPLLILDEPTVGVDPLLRIRIWEHLLAFAKEWNTTIILTTHYIEEARQANIVGLMRNGKLLSESPPQDLIDCYQMPTLEDVFLKLCVQDSERRGDDEEQAQSTAVVVHSINGAVERNVSSSQEDVVFSSDSAMLIDESRHVCKPGPSKLRCSDIFLSPAHLWALMVKNIIRIMRNPGILFFTVVIPILQTSLFCLAVGNDPRDLSVAVANLDHPPILSKLYLQQIDNYTVHQIPVDTLSLGKAGVRSGEYWGVIEMGANFSVDLLKRFQNYSSADNATIQGGSVHVYLDMTNSQIAISLQQKLLEAFQNFTQKLLPNPQIAEIPVVFEPPIYGSTRTKFVDFAAPGIILTIIFFLAMGVTALSLVTERKEGLLDRSWVAGVSSTEVMLAHILVTGLLTIIQIILVLVFILAVFKIPNEGSLALITLLCILQGFCGQAFGLFSSSVCSTEITVMQFTQGFFYPIILMSGIIWPIQSMPDVLYYISLCLPQTYANEGLRNILSKGWGMEHFEVWLGYVITLAWSLVFLTLSAVFLRIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3L5</accession>
    <name>A0A8B7Z3L5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">8-oxo-dGDP phosphatase NUDT18-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8 9 10" type="primary">LOC110983953</name>
    </gene>
    <organism evidence="4 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099365.1">
        <property type="nucleotide sequence ID" value="XM_022243673.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099366.1">
        <property type="nucleotide sequence ID" value="XM_022243674.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099367.1">
        <property type="nucleotide sequence ID" value="XM_022243675.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099368.1">
        <property type="nucleotide sequence ID" value="XM_022243676.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099369.1">
        <property type="nucleotide sequence ID" value="XM_022243677.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099370.1">
        <property type="nucleotide sequence ID" value="XM_022243678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3L5"/>
    <dbReference type="GeneID" id="110983953"/>
    <dbReference type="KEGG" id="aplc:110983953"/>
    <dbReference type="CTD" id="79873"/>
    <dbReference type="OMA" id="FPTCEIN"/>
    <dbReference type="OrthoDB" id="10005910at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044716">
        <property type="term" value="F:8-oxo-GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769:SF56">
        <property type="entry name" value="8-OXO-DGDP PHOSPHATASE NUDT18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22769">
        <property type="entry name" value="MUTT/NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022099365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022099366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022099367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022099368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022099369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022099370.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36674" checksum="FDC7F2A970A0C5F7" modified="2022-01-19" version="1">MSEIERCLANLLAGCPPPVPVPKYDFFFKAPAKTHQRPLVLRDNLSIIVAAVIFDDKCRVVLIQEAKESCRGRWYLPAGHSEPNETLQEAIQREVLEETGLEFQPSTVVRVESNHLFGYWMRFTFIGYITGGRLKTLEEADKESLQAKWTTIEDIQGQVDIKLRAHDAVYLIQTALAYLQRDPIKRHANVLPVLNPHKHMCIRVILIKRLQDEVHVLLSMEDKPHFPIIKGTSIAEEALRTLDKETFSASNGYFLRGLLCIEHLGRPHGSADGVCLNLLAVTDFQRDLKNPNFMWHHITNPEIQTTLYNRIQEYRCLNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4F5</accession>
    <name>A0A8B7Z4F5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110983349 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110983349</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098231.1">
        <property type="nucleotide sequence ID" value="XM_022242539.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983349"/>
    <dbReference type="KEGG" id="aplc:110983349"/>
    <dbReference type="OrthoDB" id="10603232at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="1095"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="491"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="703"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="776"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="865"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
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        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
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        <location>
            <begin position="719"/>
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        </location>
    </feature>
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            <begin position="790"/>
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        </location>
    </feature>
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            <begin position="803"/>
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    </feature>
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            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="989"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="1179"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022098231.1"/>
        </source>
    </evidence>
    <sequence length="1371" mass="148153" checksum="59F391E71BD844C1" modified="2022-01-19" version="1">MAEVAQVLYKAVAGDKIKPQKNPSAWAAQERQGTKRNVPELPDLAGDNVQKSRAKRTALKKKSYSPVRGPKTRQRRKQDECEVLVDHRPKSASSSFKKQKQILQIKITSPKQKQNVLAHKLPYSFSKTASTEMVDATPGSDQNIVQDAAVNQEGHQVNADQPIPETIRVPYLGTFPISGLNVNVEDAREDQNPQRANSDLPHPETGRAPGPNAAPKADRNIFQDVMNSQETKGVDAGLPVTKTGKSPYLDITPESDENARDIRVSHQEVKGAGSHEALSKTSRACYLDTTQQSDQNLVQDVGINLEPEETAGDQLLSKTKGVQTLDATPESAQNFTHVKSISQGLEGTNDHQLVPEATRVPFAKILANQPQVLLPKLSFNISIPLDCISLKKACERRGARERPSKTTTKVKEAQLTTSGQKKVAGTQSLQGFKRPSQLVPPVSDTLADELPSAAAHPQSSSSGGLQVSGQDSRSTLPLVNSERQAEPVRNDSVAEYLDCSGEIIEAPEVAHTVEVTSTEFPPPTTNCTCSEVGSGTQEGVVPCNDLYSQELERVPSESESVTCDRKSSQLYVGEDTLFDYELDNQVQIISSEYESMGPGSTDTTSEDCSELCLSSPPMKVVVTALTRPHSTDDVPLVSLTSAYRQSEARPEVALAYSHTLPPMQIFLSRMSESQQLAVPLQELASQLSADLLSPELVRLSDTTDGCSASEEVRSPCCPEEAASSDSSGEAVTPTQQETSETEVHGEADGEAVVNQQHQENAQQQAVESCRELALTGDRTTEHSDVGGTAEESSPGETDSKQITDTTVPTVTSPVSHSVPCSVAGPTQPPPVLSSSPVLSALLATMAETSLCVTAPRDVPPVALVRGRNSPENRCENPNVPEGQKTVDSSEMSQNGVSNVCPSPAVLLTAPHLSSDEVSHTTPSHFSDDLSLSLPLPPLGADFGDFPEEDCISLVCDTESFLSDFGDELMESDRKMGETDKRRKPGSPFQRGNQPQGTSGTNNQLGKDGQPQSVLGTPRKHPPLQTVDWSEVAQYQPVSRSLAGGDCPTNDLRTRLIRRDNQSAPVPTAPGRSWTAPAHLQGSADSRPHPPLRNQAIPKGYCYDFVRNGRCLRRACPYIHDRPRPQSGTPQPQCPPSVRKVIIDPQRTPATEQHEDTQNILALVNECSMALNAHQRGGRHSHDQGSEERAEASSLESAGSLESDGSASPAAIFEAAYSFQQCTSWREARDTLLDLCRRRPEVAGCQPVVAELMAKLQGPGAGASPNDGPEVLGEKFGNFVAVFRRYLAENVSDPATNTLKQTLSCLGVSCALLCCNGQRWGQARRILDCLYHHRFPCQGELTQNVLLIQQLLAKHQQPNLQDGYAAPCVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4X5</accession>
    <name>A0A8B7Z4X5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transient receptor potential cation channel subfamily A member 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100689.1">
        <property type="nucleotide sequence ID" value="XM_022244997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4X5"/>
    <dbReference type="GeneID" id="110984630"/>
    <dbReference type="KEGG" id="aplc:110984630"/>
    <dbReference type="OMA" id="PLFIRVE"/>
    <dbReference type="OrthoDB" id="1661883at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052076">
        <property type="entry name" value="TRP_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143:SF3">
        <property type="entry name" value="PWWP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47143">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL PROTEIN PAINLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1010"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1042"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="338"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="372"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="405"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="445"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="478"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="511"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="544"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="615"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="682"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="748"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022100689.1"/>
        </source>
    </evidence>
    <sequence length="1134" mass="126176" checksum="F407ECB19B331311" modified="2022-01-19" version="1">MSSSPAIGSGSHRPNTVSLSHSDSEALLEAEAAKGLPPVVHPYAYHSPLEVSDHLPAGVGEQDVIGDPSETLTTPNTQKVQTTRPESAPSEHSEASVSCINVLPPPWSARVAPSEDKKLINSSDNQENREPIDSPEGTASVLSSSAGTMPRSDGGLDREDTVEMREYRRRQENGDPPDKPRYAPSWPTPEELDEAEGLGRGLKTSDSTEDLSNLISIHQAARDGATELMSRYLEQIGSNKRRRVNKLDENNLSALHYAARYNHEEIVKLLIKHHADPQCKGEDNTTPMHHAARCKRSSTKASPTGSGDDDDDDNDDMSGGVISYLEAEGADVNAQDIYGQTPLHFAAMRGNDIATKELLSSEKIKFEATDKQLMTPLHMACTHGHLVITKMLIQQGAMLRCLDEEGNTPLLKACMEGHVDIVQLLFEAGEEKNILEQMLTDADYDQNTPLHVAVESGKQQIVQMCLEKGANMNIFDKQRNTPLHIAAAAGHLDIVKMLLSKTANVDSLNADRATPLHRACAFNREEVVEYLLKSGARIERRDKDNFTPLLIAASNGHSATISVLLKYGANIRAVDKHEKSSIYWAAQENEVQALKVLLDHRKHKAKKLLMASDRYNNTPLHVAAENGFINVIKILLDHGANLEAKNEEEQTALHLAAQHGRVHTLKELVRQDLTGINDEDENSNTPLHLAASEGHAKCVLALIDAGADIEARNQSLWTPLDCSAASGWVKCATALLENDSPIDPTDKAKTTPLHLASKNGHVDMVKLLCERGADLSLKDESDYNCLDHAIDKGHEDVARAIIAHKHWQHAMYSVSRDKFTKMRSTPMRKLIKKMPDVAIAVFNRCVSENDYPPEHKRYCITFDYELLDDMFSKWDDNSPDNVSEVSGNSDDNSPFLENGNLSPTAVPYSSSSKMLRVNHPLTIMVKSKRDDLLGHPLVTSLMQHKWDSYGRFFYYSSLLFYALFLVFLTGYVVTNPPSFYYKVNSTDGTFEWMADGQQRWERDFSSATHFLFGNVGHWVIIVLSAVNILKELGQLFHQKLNYIGWVNLLEWAIYVLSILFVLPLSGVYYPYGTSTTDCSTSSDTNCIMLRLDWQWQIGAVAVFLAWINLILFLRKFPQFGIYIVMFTGKPDPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z548</accession>
    <name>A0A8B7Z548_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Nuclear factor related to kappa-B-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC110983483</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022098459.1">
        <property type="nucleotide sequence ID" value="XM_022242767.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098461.1">
        <property type="nucleotide sequence ID" value="XM_022242769.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098462.1">
        <property type="nucleotide sequence ID" value="XM_022242770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983483"/>
    <dbReference type="KEGG" id="aplc:110983483"/>
    <dbReference type="CTD" id="4798"/>
    <dbReference type="OMA" id="WLPIELI"/>
    <dbReference type="OrthoDB" id="70874at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21865">
        <property type="entry name" value="DEUBAD_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2430">
        <property type="entry name" value="NFRKB winged helix-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024867">
        <property type="entry name" value="NFRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025220">
        <property type="entry name" value="NFRKB_WH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057748">
        <property type="entry name" value="NFRKB_WH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038106">
        <property type="entry name" value="NFRKB_winged_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052">
        <property type="entry name" value="NFRKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052:SF3">
        <property type="entry name" value="NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14465">
        <property type="entry name" value="WHD_1st_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25793">
        <property type="entry name" value="WHD_2nd_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEUBAD" evidence="4">
        <location>
            <begin position="157"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="885"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1059"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1136"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1173"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1429"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="893"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1072"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1185"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1431"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1442"/>
            <end position="1453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022098459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022098461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022098462.1"/>
        </source>
    </evidence>
    <sequence length="1467" mass="158832" checksum="4EB87DB09B51EFDF" modified="2022-01-19" version="1">MATQDDLASSNPDANVRQDKDLVESAMTRQLSVSLGRRISLDDLNENSHNETVAVDSPQNGEVDVVTVDNSPGEGAPLTGRKILPVSPEMARPAPKHKRASSPARQHSPASASRSPRANWPSPRSSQSSPGRADAPTGNKNRRFEACILNKAKVWLPIELIEQPKIFHEVVSLETWNNVLTDEDRERLSKMLPDFPESDSQEKMETLRRLFAGENFKFGSPVKKLQKDLRAGYLYLEVFKHKRALRQAKYREYKHQQELRCHRMLKEVLISRQELLEAAQFTAPDEPFKVKRPRPMTVQKDLDEIVTKKYRKILKECRIECGELYTSDEDDDVFIAKDKTPTKKRPSAWYEAPSDIVLPRFTPRVQSTFDPKPISLQSGAGPDGSPNGDDVVIPPAAPDSPLQLTEASYMDMIDKHQRTRNAGMDHFELDTSNITLEEVMTRTFSTQNSPIVPSRDFRDKSMQLSQKRKAKIKDKLAKKRKKGRPPKATTPISVMSMESRTSVATTESSGSVSTNQEGPTVSMDVGKDEDVSSVQSSQKSVLYPNFFSFLRDTLKESPDSHMTLAELQARTEAWQGAPVSALNVWFTLMASWSQAVGSMLKFLIGELPSMPIKSPVVEYSDTTHTWGWIGDGRDSDEQLTILFKQWLTAVLEDKPTPPEVERQASPTVPSPIKVRTDYVVRPSTLEEKALFRAQEHERYEQPHKAYTYRMHGYKSVVGPVKGVYGKETSLNKAREHSLLVSDRPPYVTILSLVRDAVARLPNGEGTRAEVCELLKDSKFLADATDNQINTVVSGALDRLHYEKDPCVKYDGNRKLWIYLHRNRTEEEFERLHLEQAVSVKAKRSIQKQPKLMHKAKTVIKDMQLFHQAVRPPSVLSDTSNDSIISVGMGLETPSPSRSPGSSSISPHSFAKSPASSTTQSPIAGILAGKTGKRGSKVGATAQPQVLQRHLSSPAAISGSQALSPQVQALLTHAAMPSVLVPTSAASSEAGPYQSGNSLIKAQLLAPRGFVAQLTSQQLSTSVPKSSQAVRTITTATQMSAVPVPPLMVGQLLSHPDQAQHQSTEIPGRTGDMVSSTKPGLVPSTNQPITLTLTGANTVSDKSKTQPSSTIPAALAFHSKPGTLPVNVTLTLKGATEEKKAATGGGTSRGHGGKTKLPTVGGLLAGLGMPLEGVSTSRVGRKSSSKAKSPPRASVSKAAASQSSIQSPVSRKKSQPKAEAPAIDKVLTLQAVTSATLVPPQKPPLLASPMIVGSVAAGVHQPSASGLIFQPQVAATAKPSSTNSSKTATLTVTQASAIRTLTSLASQQTLQDKPHLDRSNIATSQQTHSEIPSIPMSLFMASSGPQGATMGQGVKSVSVVGSLHQGAIPLITNPLLSTGIPASLTPGKGVILQVPIGSKRVSAIPAAISKQKCTAPVILTSSTLTSSLMTPVVTQESTNASRDQTEPSTKKSEEVSTNQVAKDFSKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5C7</accession>
    <name>A0A8B7Z5C7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Ankyrin repeat family A protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110984712</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100837.1">
        <property type="nucleotide sequence ID" value="XM_022245145.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100838.1">
        <property type="nucleotide sequence ID" value="XM_022245146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5C7"/>
    <dbReference type="GeneID" id="110984712"/>
    <dbReference type="KEGG" id="aplc:110984712"/>
    <dbReference type="OMA" id="PYTCNEL"/>
    <dbReference type="OrthoDB" id="10251692at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF15">
        <property type="entry name" value="LP07441P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022100837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022100838.1"/>
        </source>
    </evidence>
    <sequence length="328" mass="35221" checksum="DA7640A2EA65B00E" modified="2022-01-19" version="1">MDPSKVPYPVSISVCTRTGDVPSNVITTPTTMVGFQLQANPNPIQVAAPSESKIPISAAIPAMLTTPLDYNGSQPTVVHVAPSMMAVDRVLNALSDQDQASSDLEVQSVMCPETRNLLPTLKPVCTSRSSSSSKSSKSSYSPMRLQISMTNTKRGNVQSVTPTCLYNYSIHQLAAQGEIAVLEEKFQEELDIDELDADGCTPLMWACAHQQTDIVQHLLAHGADVTKESVDGETALAFASSVGCIDIIRLLLTEGADVNKSDWNEGTPLLYAVYKNHPVCVRLLLEAGADLTVQTEGGHTPLSLAVALGHREVQLTIEKHMISLLQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z644</accession>
    <name>A0A8B7Z644_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984395</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100265.1">
        <property type="nucleotide sequence ID" value="XM_022244573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z644"/>
    <dbReference type="GeneID" id="110984395"/>
    <dbReference type="KEGG" id="aplc:110984395"/>
    <dbReference type="OMA" id="QLTHQVI"/>
    <dbReference type="OrthoDB" id="7701031at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34718">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34718:SF2">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100265.1"/>
        </source>
    </evidence>
    <sequence length="325" mass="36375" checksum="36AB7B97187BDF77" modified="2022-01-19" version="1">MAPVGLSETCVATRDERDTVEPSTPARQSVDVCFDEQSKRIKLIIRGLSLNRERVSPWNQFQSAGLKRKATSSEDSHSVSPKKARPSLDSNIPDATTTQSKAESDFWVPELGLRCRDRTILTDGDWLTDSHIVAAQQLLHRQFPGLEGLQEPVLGNVLQFKPIVSDGIQVIQNGSNHWVTLRKLGKKVKVMDSKNMGLTRQLTHQVINLCGVDGDGDGEAAGGSSTLEVRLPRMHRQRGSSDCGVFALAYATEVAFQGNPELVVYEQRRLRQHLQECLEFREMRPFPKKACKERTAREIGDRMQIVQKISPRLPYAEPIGHQRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7L6</accession>
    <name>A0A8B7Z7L6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase TRIM56-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110983928</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099296.1">
        <property type="nucleotide sequence ID" value="XM_022243604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7L6"/>
    <dbReference type="GeneID" id="110983928"/>
    <dbReference type="KEGG" id="aplc:110983928"/>
    <dbReference type="OMA" id="NNEASHH"/>
    <dbReference type="OrthoDB" id="10066958at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021978">
        <property type="entry name" value="PML-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
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    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12126">
        <property type="entry name" value="PML_CC"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
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    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="61"/>
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    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="98"/>
            <end position="145"/>
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    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="164"/>
            <end position="202"/>
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    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50119"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022099296.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="70800" checksum="92A61F686E4DA572" modified="2022-01-19" version="1">MATRASIPSGVEKHLECPICGDRYRRPKVLNCLHSFCEECLVKYRNGRYKYHPKIPCPVCRQETTLPRTGITGLKTNFHLVGLIEEFTPQEKAAYSLGSRLLCQTCKENNEASHHCIDCGKNICLKCYEDHFRFPALSSHAVVTLDEICGGKVKVIKQLDGYKCHQHNDRVKRFYCKTCDELICQGCTVVEHAKPNHDITDSKTAAKILRESLTDKFPAFNKDVQDLEYRLWDAAKAKTALNSNKAKAQKEVQERAAAVIAKVRAEEKRILGEITTRVQEQNERLDEYEKTLSDLLRRRKHSLKSALDIVQNTSDYDFLSLHSVISNDLDELRGQQTPKITGLQSYPVFVQSNMLDVDLGNVVMRDTWELCLTFGQQGSGDGEFQSARSIAAAAAEPDEMAVADWKNKRVIICNNQGPTGKFLAINANDVVAMTNHWLCANISKVLMYRRDATLACEFYTVPETEVHGEIDVQLVSVAVMKNGNILVGDRKRKVLTEHKPDDGKLIQTTPVRIVPYWLAVMSNGWIVISDRDQGLVEIMDVSDGNAIPIATIQPTIDGQQVKHCSGVVSTSSGIFVAACTSYTKTGHIHHYNSVGQFVGCVAKGLYNPCGITLTADGQQLAVADWHSVKIYHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8S3</accession>
    <name>A0A8B7Z8S3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cadherin EGF LAG seven-pass G-type receptor 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110984899</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101210.1">
        <property type="nucleotide sequence ID" value="XM_022245518.1"/>
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    <dbReference type="GeneID" id="110984899"/>
    <dbReference type="KEGG" id="aplc:110984899"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001736">
        <property type="term" value="P:establishment of planar polarity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120036">
        <property type="term" value="P:plasma membrane bounded cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007423">
        <property type="term" value="P:sensory organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000029">
        <property type="entry name" value="Cadherin EGF LAG seven-pass G-type receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000020">
        <property type="entry name" value="Dachsous cadherin-related 1b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000080">
        <property type="entry name" value="FAT atypical cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000024">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056286">
        <property type="entry name" value="Cadherin_CELSR1-3_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026">
        <property type="entry name" value="FAT ATYPICAL CADHERIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24026:SF51">
        <property type="entry name" value="PROTOCADHERIN-LIKE WING POLARITY PROTEIN STAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23592">
        <property type="entry name" value="Cadherin_CELSR2_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="45"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="153"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="261"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="364"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="469"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="571"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="673"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="779"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1139"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="1179"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="14">
        <location>
            <begin position="1218"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="1165"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022101210.1"/>
        </source>
    </evidence>
    <sequence length="1348" mass="150950" checksum="1D99CA1946923CA4" modified="2022-01-19" version="1">MYNLIFELLEQACFPELRLQKSLSLTLVPQKLNNRXRRNRSPNFPQGMYIANIPEEQPVGYIVMTITASDTDSGEAGRLTYSMLAERDARSQNMFSIDPDSGIITTTQRLDRESIEEHLFEVTATDHGSPQRSTSAFLQIMVEDLNDHRPEFELTEYHIEIGENEPAGTTLYELHASDGDSNFNAVVRYSIINPEPPNDAFHINSRSGIITTRARLDREVVSSYELIVLAQDLGTNPGPLNTTARVLITVLDENDNYPQFSKRTFEVTIPEDSPRNVIIETITATDRDAGSNADIRYSMVGGQGHFVIDPYNGEILLTSALDYENTPSYQLVVHAQDSGRSARSNSTCVIVNILDVNDNSPRFPTTLYQTSIREDARIDSSVITLNAFDGDSGEFARITYSIQDPDTALPFTINTDTGQITTSSLLDRETSPLYEFTVVASDQGDPPKTATTEVSVRITDVNDNPPVFTQSEYYGRVDEDASPGLTVVTVSAYDPDVGNSVSYQITAGNTRNRFNIISQNNRGMITVALPLDYKQEPHFVLTVTASNNEQSSMCLVYINVTDANTYRLVFDQSPYRAEVAENVAVGYVVVQVHATDGDVGENARITYSMDSIPSFEIDPDSGEIKTRTELDRETTSSYTIHVTASDHGLEPQIDTTEVEIFLTDINDNPPVFTESAYSTEISESVSPQSLVIQIEAEDADEGTNSQISYTFNNGNDGNGAFVIDETSGIIRTAVCLDREAKAEYNLVAFAVDGGRPTHRETVQITVRLRDENDNPPEFLQEEMDVYIAENRNPGELVSTIIANDPDEGYNAIIHYSLIAGDLDFFEIDSRSGELTTLIELDYEARNEYQVTVKATSTPFFRLATVNIHVEDQNDNSPILEDFEIFFNYYEGFFPEGDIGQVPAHDQDVSDTLQYLIMRGNANNHLILNGTTGGIRLNPSLRNIDIPQRMEMWIQVSDGLNVVSAQCTFRLTMVTDNMLMSSITVQLEDTNSQEFLSAKINRFIDALSNIIPTQRNLVYVFSIKNHDIVSDPPILDVSFAAQHQDGTFFTSQYLQERVYLMRSILSEVSLVKVLPFGDNLCLYEVCSSENMHYRCLSPLSFWSSSGFIATQTVIFRSIHPETLYRCECPPGFTGNYCTTEINYCYSNPCGSNGQCIQKEAGYTCVCNDNFAGPNCEIDFKNGRCTDNLCKNGGLCRNFLRGGFECVCPGEDYDGDLCEIRTRNFPENSFLMFRSLNRRVRFQMSLSFATKVDNGLLFYNGRYNQKHDFIALEIVNRQVRFLFSAGEVTSVVTTSILGGVSNGEWHKVVVDYHERLAFGTVIIVKDHQLQHQRKIVKDHQHLLQGEVKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z949</accession>
    <name>A0A8B7Z949_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110985463</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102193.1">
        <property type="nucleotide sequence ID" value="XM_022246501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985463"/>
    <dbReference type="KEGG" id="aplc:110985463"/>
    <dbReference type="OMA" id="PLMVSTC"/>
    <dbReference type="OrthoDB" id="6086604at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055445">
        <property type="entry name" value="ARM_ARMC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23312:SF8">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23312">
        <property type="entry name" value="ARMC5 ARMADILLO REPEAT-CONTAINING -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24768">
        <property type="entry name" value="ARM_ARMC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ARM" evidence="1">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="1184"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="586"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="945"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1005"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102193.1"/>
        </source>
    </evidence>
    <sequence length="1360" mass="150942" checksum="17F0D44CC166B722" modified="2022-01-19" version="1">MAASSDTSHVSGRGSRRAPPSLRDIVQKLRTGSSSNLEDGLQMIQGLVRKNRGLEVVDEFRRLGGLEEIVQVVKSDRCDIDRNEKLTDLALSVLATCCREQESKIRVHELEGIPAIVEVLKAHTSVSIINRASRALANLAEVPKLCADIHHKDIIPQLIRLLKETPDSSCRQSILRLIRILADTNQHAWKILQSEGLSAVLNCLDSDDIKLIGCAAQTAAELTNHLGSGQSTEALRSYQEAGRQAVEDNRVEVLVRLLSHSKPSIQDHALVALLNLMVSEGVRVAAGKAGGVEVFIERGKATTFPGWATYIHCLCFCCREAVNRVRLRNLEGLQVLLNILKSSSEDCVRLHETILVALMDFYYDEQSLNYLAACGFIQVLVSQLRQEVMTSARSGRDDLTESEFDSSMSSSRCTDDVTVTGAFPSTSRKRARSFSEGPDKKQVCNVKSFIGMQACSSKDTPLPGPKAKKTCLLAPAKPQDDAQSRMGLSSTAMSVTIQATEMMEDEDTSSSLPSSSASGMSPESSATNYQSYINPEATPYSPPSVDWEWFLQHREQMGQGLSPRSFSSFSSPRSLSPLRYDFSPMSSPQWSPQWSPQHSPEYSHHQAPQWSPQHSPQWEPQPSPDQSDHLFPQPLQENESPVSESLSQTLSSKPSTLEIVAPDEPPTAFGHLESVGASSKDVQGSTASIASMSEEAPVHKSLIKSHQQTLTDSLSQGSTLQAVCNLTLDEKAKISKVGCATDSLLTEKDILMTGFAKRLDEHVTSINTAEYGQEAGTFREPHSKSLRMRTGRNKTTSVHRQTADAPSMDDPESDTNMLSFMGSKEPKEKILVDKFEIDMEIRRAKEEGKLRRREYAAVTLLSRYSHMDDPSTHMARESVVSVLLDYQPSSAYLQSKSQRTLHRILRNRLCFEQLIMEHIPMLIARKMIERESKKLATAMETNNVNSTVKRSQSTNDLRSMQSRAAHGEIKTSGGSSQEMRDPRKIKLETSHSSVSEPKTTSTEVASSRKIWPRRKESFDSDVVSDFLDDSASDTTSVCSLDTVESEQSQLWGDTASPLYPLMVSTCQFRQGTMLRLLMSNSFKGKMACVLAIPYICQTNSLKRRLLIKHKGLQILLDFLRKDTIMPDTFNKAVQCLFDLSTALFLNPDETETILKTDDRSNIRTVKEVQSQEQGCCYDAVEQQADTKLLVDQEEAVQAHRSILTKSSEYFTCLLEGPYLESGQSEVPLKEISKEALTLILHSLYGCLHLQCCHMNEVTASGDKVVLEAIACSGRFLLWPVQNRLCDIIVDSHISAASVVSHFQFGLKHNCSKLTNACLMFMLTSGKVTHEHFQELVERGCANDAFKTIERMITDALFSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9G2</accession>
    <name>A0A8B7Z9G2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nucleoporin Nup37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Nup107-160 subcomplex subunit Nup37</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110985041</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101445.1">
        <property type="nucleotide sequence ID" value="XM_022245753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9G2"/>
    <dbReference type="GeneID" id="110985041"/>
    <dbReference type="KEGG" id="aplc:110985041"/>
    <dbReference type="CTD" id="79023"/>
    <dbReference type="OMA" id="FWKVQIK"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000168">
        <property type="entry name" value="Nucleoporin Nup37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="17" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="14" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 22" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="22">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022101445.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35855" checksum="651B025BCEB5EE00" modified="2022-01-19" version="1">MVENVKGNSFDLPCKDVVTCIEFCPFESASQLIAFGSQLRISIGSVRFQEEDKTVAGFDYQHLRDFHHDTQVVAISWSPETSLEVLPRCVRFCTAGADNKIRLYTSDMKEQDKMELMDGHLDFVNALAFEPTEGQLIASVSDDHTCRVWGIDGVQRACFSLKAAGMSACWNSQDPMKLMVAEKRGTIRFYDLLNQQPIMSLDAGHVMLRSADWCVCDPTRVGAAVEGEWMVWDITRSSRPEDNQQAHTEGTQQFRWSRVSENIFATTGRPGNQVKVFHMGHHQVPVSSEVPVLGGLSWHAFLPVCAVGGDRKIHVWITEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB49</accession>
    <name>A0A8B7ZB49_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein wntless homolog A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110985814</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wntless family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102878.1">
        <property type="nucleotide sequence ID" value="XM_022247186.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985814"/>
    <dbReference type="KEGG" id="aplc:110985814"/>
    <dbReference type="CTD" id="79971"/>
    <dbReference type="OMA" id="ACESNAM"/>
    <dbReference type="OrthoDB" id="5804250at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061355">
        <property type="term" value="P:Wnt protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053936">
        <property type="entry name" value="WLS_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009551">
        <property type="entry name" value="Wntless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN GPR177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13449:SF2">
        <property type="entry name" value="PROTEIN WNTLESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21883">
        <property type="entry name" value="WLS_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless GOLD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="10">
        <location>
            <begin position="50"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022102878.1"/>
        </source>
    </evidence>
    <sequence length="372" mass="42791" checksum="C7192A3591228BA4" modified="2022-01-19" version="1">MPLFELGSVHHKHYLINIRLPVTKDKETGALTNINIGSPQDVHVVIIHQNGGFTIVWMSLKTFMFPFVLLVTVWFWRRVKTQGKPSVLLERTIFALAIIMSILNFPLEWLTFWVDIPFMTLLSDIKQGAFYAMLFSFWIIFIGEHLMDQTQRNRLKVYRQQVCSIIFTFFCLFVFDMCERXXXXXXPFFSMWNTDKGVKLAMAFIILAGICLSCYCLFLIFMVYQVFKNISMRRATLPHMAKARRLHYEGLIYRFRFFMIFTVITAILTVIFFIMSQVLEGHQKAGERKPSVQYTSGFYTGVYGMWNIYVVAVLVLYAPSHKKTAATSNGEGSEGSHVEFEIDVPSGERSTNPTAAGALTEAYQLLSKTATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBC8</accession>
    <name>A0A8B7ZBC8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NADPH oxidase 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110984552</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022100536.1">
        <property type="nucleotide sequence ID" value="XM_022244844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBC8"/>
    <dbReference type="GeneID" id="110984552"/>
    <dbReference type="KEGG" id="aplc:110984552"/>
    <dbReference type="OMA" id="WFVVPGC"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000056">
        <property type="entry name" value="NADPH oxidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000012">
        <property type="entry name" value="NADPH oxidase, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF58">
        <property type="entry name" value="NADPH OXIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="47"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="403"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="498"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
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            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022100536.1"/>
        </source>
    </evidence>
    <sequence length="800" mass="91455" checksum="B8B3DFBD67B6E4D7" modified="2022-01-19" version="1">MEKGEEFRLTVEDDAKWLEWAQRQFAAIAGNDRLIDWQEFKSALKVKKEFFAKRFFALFDADNSGTISLDELMDGLRMLTHGEPAEKLRFLFNVYDVDGSGQIDHEELRTVLESCMEESALQLSSSVLDELTDALFEAADEDGSGAISFDELRRELEKYPDVMENMTIGAAGWLKPPEDQPKTRMRMPRYLTLRYINNNLRKVIFVIAYCLLNAALFTEAAHRFASNGANWCIVIARGCGQCLNLNGSLILVLMLRQTLTYVRSTRLARFLPIDQHIIFHKTVGLIIAALSLVHSLAHVGNAVIITSPSGPLPNNTAWEVLFTQPHLTPLGLVKHSAFLTGWLLDIILVVMVICSLPFVRRSGNFQVFYWTHLMYIFFWVLLLMHGPRFWYWFIIPGIIFILERISQLRLVRQAQFGKMYVEKAELMPSGVTHLMITRPPHFDYSPGDYLFLNIPEIAKHEWHPFTISSAPEQPDTLSLHIRSAGNWTNKLYSFFEERHKRNRQQSIRNRSRRANGSTSTEKAGEDDSVCLDVPPSPPSDSYRYRPGGEKVMSRQPVTKSMSWSDKNGKTATYVEVSTGKKHSNGKHRKLKRHPAEERIEVFINGPYGTATRAIFRAEHAVLIGAGIGVTPFASILQSIMLRCRTNQQTCPNCHHEWIGSVPEHVMRIKKVDFIWINRNQKAFEWFVRLLTQLELQQAGMSERFLDMHMFMTAALGKTDMKGVGLQMALDIMHSKGNKDMITGLKTRTQPGRPDWDKLFADIAGQRKGKVQVFFCGSPILGKTIKAMCEKFKFHFHKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC99</accession>
    <name>A0A8B7ZC99_ACAPL</name>
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        <submittedName>
            <fullName evidence="12">Protein trapped in endoderm-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110985622</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102455.1">
        <property type="nucleotide sequence ID" value="XM_022246763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZC99"/>
    <dbReference type="GeneID" id="110985622"/>
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    <dbReference type="OMA" id="HINICRA"/>
    <dbReference type="OrthoDB" id="6117944at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF74">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="75"/>
            <end position="96"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="116"/>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="180"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="200"/>
            <end position="225"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <end position="292"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="304"/>
            <end position="325"/>
        </location>
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            <begin position="55"/>
            <end position="323"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022102455.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="39626" checksum="8FD12101D3F609F7" modified="2022-01-19" version="1">MENSSLVTDINATLNRTANPVDVTGDFDSPRKYSLLVQYWALVVGIPVDALGFWGNLMTIIAVAKTSALRTPTNLFIISLSVSDLLYCIIVLPVLLTVYNHNAWVFGPVFCRIHPLLMITFVGATIMSLAGTAFGRCLKITQSPLYGKLFTIKWRATVMILVCWLLPLIFLLPPITGVWGDLGYEPKTLTCTFLRGGSNSGYSMFFMISALIIPTFSITFCYLRILQTVCANHKRVQKMRKAVVNEVSGATRARDSMKRQRTTAYREDIQYTKMMLCIFLVFIVCYVPYMMATLVDPQVKNMTFHFFCGSCVWFSSCLNPIVYVIMNKHFRKAFAGLLPATTRGRAATEVVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCN5</accession>
    <name>A0A8B7ZCN5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC110986109</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110986109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103444.1">
        <property type="nucleotide sequence ID" value="XM_022247752.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986109"/>
    <dbReference type="KEGG" id="aplc:110986109"/>
    <dbReference type="OMA" id="LHEADCA"/>
    <dbReference type="OrthoDB" id="6275838at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
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    </dbReference>
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    <dbReference type="InterPro" id="IPR032471">
        <property type="entry name" value="AGRL2-4_GAIN_subdom_A"/>
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    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12011:SF471">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1119"/>
            <end position="1139"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1145"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1199"/>
            <end position="1219"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="1239"/>
            <end position="1261"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="1282"/>
            <end position="1303"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1309"/>
            <end position="1328"/>
        </location>
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        <location>
            <begin position="912"/>
            <end position="1075"/>
        </location>
    </feature>
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        <location>
            <begin position="1084"/>
            <end position="1333"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1361"/>
            <end position="1392"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022103444.1"/>
        </source>
    </evidence>
    <sequence length="1392" mass="155902" checksum="05DD6399EE90BDBF" modified="2022-01-19" version="1">MAAYINSHRSGTLDVIRTQLPVDNVTSSLPPWVVTIGGTADELQVLRSADYLWTTDGYFRRDHVSLWTQPGIAATGPITHSSHWIQAPGRDGKGWAVDVDGASNQWLVLGDDFAGTCVSDPSLCPEGITVALWVKLRNSAGADNTSFAFIFSTGGQSSRGCALYQQGGDRLRATVADGRRQWIVEIIFVPDEENWVHLAISWRQSSGLVLYIDGESHGRDHVGRIRIRHNDLDSLLLVGRRNDYLAGYANLTLEQLAIWEHYTEPWQARRKMGLIENSYYARATYYWNQRRFISSTFDILSNSAGIVGPSSNVAVPYSDMVDLSSPGSYIDLGDFHGRCVSDPTKCSAGLSVSLWLKYQQGVTSATPSFIIRTREYGLQHPGFVMYINDARLYAVVQNSVGRWFAALKMENFPSDEWVNLAFTWSETQSLTLYINGIEPPKVQYHFEPKPYTPNPMSRLVLGATSTPTPSHPVTFQVHSLAVWETHISQGKIHQLLGMSKESEYYCFHYGDFCWSFEPTLHLRYPFKLSPAGASFTNDRYDQAMAVCTDGRSGWISLRDFTNQCPADPSTCEHGFIIAMWVRLQEITSHRRSSYLLSVGAEEHGENGVSLFQSVTGIRVKVVDNHLSWETNIESSWLSFGQWIYLSISWAGQYLKVNVGGKELPIITHIHRSSLPDAGTRYVNDRLVMTLGKSIHGSRGFVSACYDDVLLRVPEADQELPSPKNLNGSVSEDENQSLGLDEPGPETAKKECAIIHEADCALTIEELFYTIKEETVLSDDAVYSSVIKLNHLTENREKLSSSELDAASKVISRLASRELPLSINITEAEIYLEDFLTIVNNLLHPVHAQEWISLQRSHAGITSLMDSVETFTGKIAWHWNTTIGNSVTDVLVNKGNILTTMEIIPEDDLKSKKELVIPRRSRLEQLAKDWQNVDETISIPGDIFVNTPSSAAVRFLFTLYDTLQDMVPCTATNQFQKVDGKSLWINSPILSVNAEPPVEGIFKEPILITLSHQTPVADPTTAKVVCAFWNFSVPHTINGAWDCEGCELQSTNQMQTVCRCYHMTHFAIIMEPQPDKELSTDAVVLRWLLRCLVCLSVLLLLTLMIAYIASKRLHTLRHSIHLNQCLACLLASLVFGLSEITSEDEVFCLVSGATMHYLYLAVVFWSTMEICQLYRDTTVGGMDTSDAMKGFTVWRNRMKYYMIGGWGFPAVVVGSLMAVSKQAYRPQAHDLCWLIEVDGVPWAYSAPCCLALCVNIFVLILVMRETDDTLRKLDRTTGFRSSVRGAVFLTILYAVTWMVGWKAIYGGPVWTSYLFVILNSLQGFFFFVLQGFGNVEVRALLCRDDPDLELALANNTSLVLEQPREKPSYAESAVYGPEDPSQPSRRSSHQVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEC1</accession>
    <name>A0A8B7ZEC1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ homolog subfamily C member 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101556.1">
        <property type="nucleotide sequence ID" value="XM_022245864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEC1"/>
    <dbReference type="GeneID" id="110985100"/>
    <dbReference type="KEGG" id="aplc:110985100"/>
    <dbReference type="CTD" id="54943"/>
    <dbReference type="OMA" id="EWISLGK"/>
    <dbReference type="OrthoDB" id="1922282at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052573">
        <property type="entry name" value="DnaJ_C_subfamily_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158">
        <property type="entry name" value="OS08G0560600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="71"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022101556.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="48059" checksum="7A3AA18AF8E43503" modified="2022-01-19" version="1">MKSLLATRVNIAVQGRSAGSPAVAGKMFTMFTVMVNSHKKPIPALGYAGNWAQLHTASILSAYKLRRNVKDCYQVLNVDPESSSLSDVKEAFLRLAKEYHPDSKSPTADVRKFNQVREAYQAVRADLEARHPHLTGDSSMRDSQLDFDIEHTAPQHRQYLEFEGIGVGTPSQRHKHYQKVRVQRAMNSVSERRMERLLVNEETSALVSLDKKAAKQIKTSNIMDRLVEDLIKDAMNKGEFENLPNKGKPLPDKTRWCPYWDVGDHNLNQVLVNNGYTPEWIQAEREIRSELRDLKDDLLKARLKLGPEPLNEFNQNKWRGLLEDFMESIKSLNKKVERRNLLVPALQLQIVHFRPEREIEKVLKEYDKLEETKIKIKEEKSREMQQTEKALILDGQLFAKIGDKIFQRFFFNHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEE2</accession>
    <name>A0A8B7ZEE2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="12">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC110986448</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of 2 subunits, IMMPL1 and IMMPL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022104009.1">
        <property type="nucleotide sequence ID" value="XM_022248317.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104010.1">
        <property type="nucleotide sequence ID" value="XM_022248318.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104011.1">
        <property type="nucleotide sequence ID" value="XM_022248319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEE2"/>
    <dbReference type="GeneID" id="110986448"/>
    <dbReference type="KEGG" id="aplc:110986448"/>
    <dbReference type="CTD" id="83943"/>
    <dbReference type="OMA" id="WIPVIAW"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000005">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="103"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022104009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022104010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022104011.1"/>
        </source>
    </evidence>
    <sequence length="193" mass="21976" checksum="C375B96BB7D49B08" modified="2022-01-19" version="1">MSTARKAFKIFIGGFVFGVGGSLTFFDKVGYFATVDGKSMQPVLNPIHETQRDIIFLNHFAVREYQLKRGDIVSLASPSRPDEVLIKRVIALEGDTIRTLSYKNRYVTIPEGHCWIEGDHHSVSLDSNYFGPVALGLVHARASRIIWPLHRQQRLEPRLPKDRQPISLSPSLVEELMEEYQEVESLELEDVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFR1</accession>
    <name>A0A8B7ZFR1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Neuronal acetylcholine receptor subunit alpha-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110986347</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Synaptic cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103837.1">
        <property type="nucleotide sequence ID" value="XM_022248145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFR1"/>
    <dbReference type="GeneID" id="110986347"/>
    <dbReference type="KEGG" id="aplc:110986347"/>
    <dbReference type="OMA" id="KKDYWEN"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000078">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000005">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034159489" evidence="16">
        <location>
            <begin position="34"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="17">
        <location>
            <begin position="37"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="18">
        <location>
            <begin position="250"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="415"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022103837.1"/>
        </source>
    </evidence>
    <sequence length="576" mass="65660" checksum="6D6DAA0A9036AA2C" modified="2022-01-19" version="1">MRGPAMWTDMTAIQKWISFVLFVTMQQGQGVRASEGEERLQEFLFNDYSKLALPVKGALDTLYINFSLAISQIVDVDERNQVLTSKVWVQQVWNDYNLKWEPSHFEGIERIKVPSDAIWIPDILIYNNANGSFDMQTGAWASVDCNGTVNWSPPAVYKSSCKIDARYFPFDEQNCTMKFGSWTYDLGKIDLIPSSPSAEKKDYWENGEWTIVQSPCERHVISYLCCQEVYVDVTCTFILRRMPLYYFAYLLLPCGLISFNTVLVFYLPPDISEKMSLCTSVLLSMAWFLLLVTQRIPPTGNNFPLIVKYLLFTMVVVSSSIILTVFVLNIRYRSPHTHKMPNWVRTLFINVLPKYIALKRPERYNLRYRHVGVALTRDAVATKYVDSKKLVMESKGNNYTVRLRNEVDRDVNGLETDSEGEAIPEVNANGDAGGSRHPSLSLTPTYWAATGSAANKTDTPSSSNGLRRTSPVGQESRRTSRYLPSTNHDPDPSEAMNVHRAVEEIMYMASRYHNEDDMVRAKEDWKYVAMVVDRIFLIVFLCGVFVGTITIMLEAPLAKEFFARVFTGDDVAHTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZI24</accession>
    <name>A0A8B7ZI24_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">sphingomyelin phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110986777</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.12" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022104657.1">
        <property type="nucleotide sequence ID" value="XM_022248965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZI24"/>
    <dbReference type="GeneID" id="110986777"/>
    <dbReference type="KEGG" id="aplc:110986777"/>
    <dbReference type="CTD" id="6610"/>
    <dbReference type="OMA" id="AHRATEC"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="58"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022104657.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="52019" checksum="D197EDE56594AA8D" modified="2022-01-19" version="1">MLYVDSASAVQIALCFVEIEVGSSVWGNHRFFSGWKDIRIAKMARPWKEEKRQIRVVTLNCWGLMYVSSHREKRIGCLGDELAKGCYDVVTLQEIWMEKDYKQICDKAKDVLPYHHYFHSGFLGSGMCILSKWPIVDTLFHGYSLNSYAYRILEGDWFGGKGVGLCVIQVDDFTVNVYTTHNTAMYAPSNVFSADEHFTHRLLQGYELSKFVRFTGTNSDLNVVTGDFNTEDNSLGLKVARVNADLQDAWLDRPNQCKDEPCCTVEAPDNCYTSTKTRFYPQHPGMRIDYILYNAKPRSCCVTCRDCRLTFKKIPGTDINYSDHDGVEALFELEKGRDDQVLEPSDEEGRLGVLLEMLPYLSDSIQKITRQRFCYLLVSLLFFLLLASLWLSGAFHWQTSVYARCGALVALLALVVLGLAALCIGVSVKTTELNQLIGRKREITLNVRRLESQLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJ72</accession>
    <name>A0A8B7ZJ72_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Fumarylacetoacetase</fullName>
            <ecNumber evidence="4 15">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110987293</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="4 15"/>
    <dbReference type="RefSeq" id="XP_022105584.1">
        <property type="nucleotide sequence ID" value="XM_022249892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJ72"/>
    <dbReference type="GeneID" id="110987293"/>
    <dbReference type="KEGG" id="aplc:110987293"/>
    <dbReference type="CTD" id="2184"/>
    <dbReference type="OMA" id="YWTAAQQ"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000004">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
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        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
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        <property type="entry name" value="Fumarylacetoacetase_N"/>
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        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="16">
        <location>
            <begin position="63"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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        <location>
            <position position="72"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="163"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="163"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="170"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="174"/>
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00014741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
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            <dbReference type="PIRSR" id="PIRSR605959-1"/>
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            <dbReference type="PIRSR" id="PIRSR605959-3"/>
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        <source>
            <dbReference type="RuleBase" id="RU366008"/>
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        <source>
            <dbReference type="Pfam" id="PF01557"/>
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        <source>
            <dbReference type="Pfam" id="PF09298"/>
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    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022105584.1"/>
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    <sequence length="350" mass="38475" checksum="2B4654FE894603E3" modified="2022-01-19" version="1">MALGPPAWKEARQTLQRILSADEAVLRDNADLRAKAFVAQSSAIMHLPVKIGDYTDFYSSVFHATNVGIMFRGKENALMPNWKHLPVGYHGRASSVVVSGTPIRRPCGQTRTDDSQSPVFGPCKLMDFELEMAFFTGPGNKLGEPIPISKAQDHIFGMVVVNDWSARDIQKWEYVPLGPFLGKNLGTTISPWVVTMEALAPFIVTNHTQDPKPLPYLQHEDNFNFDINLTAAISAEGTNGPAVVSRTNFKYMYWTMKQQLAHHSVTGCNMQPGDLLASGTISGPTDDSLGCMLELCWKGTREVDLGNGIKRKFLKDGDEVILTGYCQGDGYRVGFGSCTGKLLPAVNPYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJU2</accession>
    <name>A0A8B7ZJU2_ACAPL</name>
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        <submittedName>
            <fullName evidence="24">Glutamate receptor 1-like</fullName>
        </submittedName>
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        <name evidence="24" type="primary">LOC110987464</name>
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    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Postsynaptic cell membrane</location>
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        <property type="nucleotide sequence ID" value="XM_022250206.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
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        <property type="entry name" value="Glu/Gly-bd"/>
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        <property type="entry name" value="Iono_Glu_rcpt_met"/>
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    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
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        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
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        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
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        <property type="entry name" value="Lig_chan-Glu_bd"/>
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        <property type="entry name" value="NMDARECEPTOR"/>
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        <property type="entry name" value="Lig_chan-Glu_bd"/>
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    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034972571" evidence="20">
        <location>
            <begin position="22"/>
            <end position="909"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="565"/>
            <end position="584"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="633"/>
            <end position="655"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="833"/>
            <end position="858"/>
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    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="21">
        <location>
            <begin position="418"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="22">
        <location>
            <begin position="428"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="867"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="886"/>
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        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="692"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="742"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="16">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="16">
        <location>
            <position position="670"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="16">
        <location>
            <position position="790"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="756"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034100"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00079"/>
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    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00918"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022105898.1"/>
        </source>
    </evidence>
    <sequence length="909" mass="105165" checksum="2FB32BA94EE19AE7" modified="2022-01-19" version="1">MAVTLGLVALVVGSLVGNTVSQSYKIGAMYGMHTRVDNLYKRLFTDAVTYINRDENLMNIDGTESLAVFNEPLITWTYSNPPQALRGACTFAGSVDINGLIVPSDVCPDCGGHTGRIIGNAFAPVIALDQAEGSKAYKMLPTDTELVELWISVINHYKWQDFIFIYDGDSSYSLAWVLLEMERENSWHVIPYEIYDEEDYGKMAKDLKQRRTQNYLLYMHEEERLPGLRDSMLDNGLFGDKYHWIFGNLEPPITRRYLDDKLRIHTSFLTRFKMRVQDGFDQNVLTKNPIPPRNWPFRERTAYDAMLFFAQAMTVFRRENGRYPNVVPKCGEDVRSELEPVMQKISIEGLSGEVAFNSHGDRVNYTIDVYMGKDKHNILKAGVWTQNIAHYERKYGEVWPKDKGRLNMFPFRQSDQSYIKVLSIEEPPFLMLRDHNYDRERRQVQTGDELGLDRYYGIIPELLENIRKIFEEELRMEFKYKIELVAEGYYGKRNPNTGEWDGMVKELQDSDADLAAGAFTVTRQREDVIDFTKHFHTGPIKVLIKHPNWVRDYPFAFVFSLHWDAWLVNLFAFGITILVFWMLMRYHPMEYRKQQEVGQATREQSIEFTLRNTAWMLTGIMFLRGHKLSPVSLAGRILLSAWFYFTLVMVFLYMLNLTEYVTIDKDILSINSPTDLLNEPLLKIGMVRNGPTHDYYSMSSNSEDQQLMSIMGVLDRQPFVERLRDGALRVRNDNGHYALVSEEILLTYYTQRGPWCDLYVVGDPVKRLKYAFATPSGSPLRDQITYAINKLQTSGVVQELLEKNWFGYQKCEEETLWESESVLSINGNDLEGVYYVLAMGVVLSAIIFFIDVICYWLFGSCSSVGTHPPSNPRGPGETITMTVNPREQHTRNDFDYSKPAEEKSPNMWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZK28</accession>
    <name>A0A8B7ZK28_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110987443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110987443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105869.1">
        <property type="nucleotide sequence ID" value="XM_022250177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZK28"/>
    <dbReference type="GeneID" id="110987443"/>
    <dbReference type="KEGG" id="aplc:110987443"/>
    <dbReference type="OMA" id="MATVECT"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022105869.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="38149" checksum="925F5127DB3E97E0" modified="2022-01-19" version="1">MLESQFTEKWILKCGCAHPSSEKRLPCPKLTTPSAPSVQEMSPLCGTCQGASSIDDIGHTLAKLTVTPGTVAPRSMTPHTVLPPEKSPGTVVPPVKTDATAPTVNPTAGLLCGDYETADYDLRQLTGEQYWNLNVPGGCFDYYDQPNVMCQFHFAFCKQIPPGIVGAKTGIGAAQVTNIAGSGPIILGGLSQIEQNEDDKGTQLLIRFRHGENKKCGGEDKNLQVEMHLHCDPNTHWLSAHNGSAPNMPSTTIVSLDKQLCKYTVTTMYDGACFTYQGLSAGTIVIIIFFSLVCVYLIGGAIFNKMGGAKGLEIIPNYDMWRMFPSDVMGGVVFVWGIITCRGMGSKAKAYDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZK36</accession>
    <name>A0A8B7ZK36_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase CCNB1IP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105245.1">
        <property type="nucleotide sequence ID" value="XM_022249553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZK36"/>
    <dbReference type="GeneID" id="110987107"/>
    <dbReference type="KEGG" id="aplc:110987107"/>
    <dbReference type="CTD" id="57820"/>
    <dbReference type="OMA" id="HFRPFFV"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022105245.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="32006" checksum="B46F73332F3FCF7C" modified="2022-01-19" version="1">MDEMVCNFKKCRKRLSSFAWVTSCSHIFCDEDGTKEFNKCFACPACETNLSGKFDIVRIDLSPSEQYKSMVLAGQKPDTILEVCTRAMAFWTYQIQQERIYQDYVANKSKERSAQLEQYYEHTVTKLQSEIASLKHQMSAVKKELESSKKQYHDLSDKMAERTRQHQKLQIMYDAQKRRSINVGMLDPGGSHESHRRTQAAPSISYDIPISSGDESTSRSGRHRGGGDHMRMMSPAEKEFVLRPTNTPIQSMPLAVQNRFSMEIGTPNELARRLGQRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKE7</accession>
    <name>A0A8B7ZKE7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110987180</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Sec) + L-serine + ATP = L-seryl-tRNA(Sec) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Ser) + L-serine + ATP = L-seryl-tRNA(Ser) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022105365.1">
        <property type="nucleotide sequence ID" value="XM_022249673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKE7"/>
    <dbReference type="GeneID" id="110987180"/>
    <dbReference type="KEGG" id="aplc:110987180"/>
    <dbReference type="CTD" id="6301"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.40:FF:000002">
        <property type="entry name" value="Serine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000027">
        <property type="entry name" value="Serine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="206"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="472"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="319"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="13">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022105365.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="58322" checksum="D9FA1A39454FC0DD" modified="2022-01-19" version="1">MVLDIELFRADKGGIPDKIKENQAKRYKDVTLVDKVVEADTKWRKLRYEADNLNKMKNLCSRTIGEKMKKKEPVGSEDEQLPAKIAETLNDCIAEDLKELSVSQLKKARQLIDEQIARCNEERVVCETTRKENMMEIGNFLHESVIISNDEDDNGIVKMVGDCQVKKRYSHVDLIHMIDGLDGDRGAVVSGSRGYFLKGPAVFLSQAVQQYALRLLHEKGYTPLYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKAEEATIEEKYLIATSEQPIAAYHRNEWMAVDELPKRYAGISSCFRQEVGSHGRDTRGIFRVHQFEKIEQFCITSPQDNKSWEVFDELLQNAEEFCQKLGVSYRVVNIVSGALNNAAAKKHDVEAWFPGSGAFRELVSCSNCTDYQSRRLLIRHGQTKKMNEQAEYVHMLNATMCANTRMVCVILETNQTDEGIAVPDALKPYMPDSYKDLIKFVKPAPADEPQAKKDKKQKDSGKKKAKKESVEEDVKKMTLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKH0</accession>
    <name>A0A8B7ZKH0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Melatonin receptor type 1B-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110986333</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103811.1">
        <property type="nucleotide sequence ID" value="XM_022248119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKH0"/>
    <dbReference type="GeneID" id="110986333"/>
    <dbReference type="KEGG" id="aplc:110986333"/>
    <dbReference type="OMA" id="NIFIYAW"/>
    <dbReference type="OrthoDB" id="6117944at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF75">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="41"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022103811.1"/>
        </source>
    </evidence>
    <sequence length="348" mass="38731" checksum="D11139D4F0F5AF11" modified="2022-01-19" version="1">MGTHSYLDIATTVGYESEPAKAPGIALAVFLGLASLFGAAGNGLTILAVVIDRKLRSQSSSFLIANLAVADMVVFVVIEPFLAFSTATTTWPFSRPLCAALGALVIQHMAVAVCGMTAVAVNRYYSVVKRTSYQRVFTRRKTLVVCLATWLPGLLLILPLVTNPFFADYSTYFGICIITSQNIAIGRAISVLTGLLILIGIVISLLCYLRIYKEVKDSRRRVKSLEPLPDDTRLPGGQHQPPGSHENNISRKPNPKQQINQTEIAISLNLFMVFTVFCVCWTPITVLIFVLDANDRHFHDQSDLIPDWAWQTAYKMVLFNSSFNIFIYAWRNRNFRSAYAKLLRCPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLR5</accession>
    <name>A0A8B7ZLR5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987514</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105997.1">
        <property type="nucleotide sequence ID" value="XM_022250305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLR5"/>
    <dbReference type="GeneID" id="110987514"/>
    <dbReference type="KEGG" id="aplc:110987514"/>
    <dbReference type="OMA" id="YWISVDR"/>
    <dbReference type="OrthoDB" id="5946895at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10548">
        <property type="entry name" value="cupin_CDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105997.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="51757" checksum="5504DAF06CC8318F" modified="2022-01-19" version="1">MNQVRAKRPALRETSAPRGKRSKAAFASTSRAMAPAEDTRQMPPRWHKPFPVNGQGVMIFNTDRHLLPFYASVEDKGTATGNWIALHVGVEYASFVMHGESNDSLKELRRIDQAGCGVEEGKVSYWYSYDRDNLVLKYGKGYRMEETTLMTHDFLEGVEDEEEIRRIREDLYPFFNAEGKKVIRQYDEKANVALCAARGIEVTEPMVEFDKQPLICNLPPVVLDSSKVNLFTLDKGDYTFSASLPSACKELYSNVVGCDLNYTEVEGEKVLLSDAIRYSLANGVLKEKIESKVGELGDDPNETYLRVTLGHSLGKSPGIPYVLEIWPAGHYSPIHNHGNANAVIKVLFGSITIDIFNKQSPTSSRDPLLTFEACAGNATWLNRNWYQTHKLRNPSKEYCATIQCYNYDAGDTTYWPYFDYVSENETIDEFYPGSDFGFSEMREQVMAEYTAYVYGNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMX6</accession>
    <name>A0A8B7ZMX6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloprotease TIKI homolog</fullName>
            <ecNumber evidence="13">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110988049</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Metalloprotease that acts as a negative regulator of the Wnt signaling pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="13">Divalent metal cations. Mn(2+) or Co(2+).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the TIKI family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_022106958.1">
        <property type="nucleotide sequence ID" value="XM_022251266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMX6"/>
    <dbReference type="GeneID" id="110988049"/>
    <dbReference type="KEGG" id="aplc:110988049"/>
    <dbReference type="OrthoDB" id="10040378at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14789">
        <property type="entry name" value="Tiki"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040230">
        <property type="entry name" value="TIKI1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120">
        <property type="entry name" value="METALLOPROTEASE TIKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120:SF6">
        <property type="entry name" value="METALLOPROTEASE TIKI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022106958.1"/>
        </source>
    </evidence>
    <sequence length="535" mass="61681" checksum="746FF278A1E188E1" modified="2022-01-19" version="1">MIFREVVRVNHGKMPVFGHAWMMSLIPVFYLFLLALPISGSVQRLREKLHCENRNSTAEGVKSFLWRVKRDTPAYFFGTIHVPYTRVWDYIPGNIKQAFGESENIFFELDLTDTYTISTLTNCQLLPHGENLSDVLPRSLFERLREHLEYVKIMMPSWMTADQRGRGLYADYLFNAIAGNWERKRPIWVMLMVNALTETDIKSRGIPVLDLFLAQEAMRMNKRTGAVERVEEQCVPLNGLNFTQVLFALNQTLWQQEIMRAAAGTARRHYTTEDLIWHYNCGNLNSVIFNHDTAQVPNLLNSTLGPYEISLAQEIDEYFREELIYKRNRRMAARVKEILDLYPEKSFFFAFGAGHFLGNSTVLDQLINEGFEIENVPAYEDVRLQHSSVDSDDLAWHVASTETTSKGKKPRPRKTRRRKKKKNPQVDPSGVKTQQDKSGGVGNLHLQVGEVEKKVEKYRQFNDLWVPLKDFSTPTPSEHLKEGSEVTDSTYQDSWHNYKSCGRSALRTASNLYVTLTLVGNIVMTRICILLLPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNA9</accession>
    <name>A0A8B7ZNA9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110988002</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110988002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106919.1">
        <property type="nucleotide sequence ID" value="XM_022251227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNA9"/>
    <dbReference type="GeneID" id="110988002"/>
    <dbReference type="KEGG" id="aplc:110988002"/>
    <dbReference type="OrthoDB" id="10069970at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="5">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022106919.1"/>
        </source>
    </evidence>
    <sequence length="136" mass="15555" checksum="65D455847E09EB21" modified="2022-01-19" version="1">MPKESAITKSLSILNSEQQQAVLANPENNLLIIAGPGTGKTTVLTEHDFVDNHQRVNLMTLHGAKGLEFKHVFLFQVTEEIFPSRLNLDIEEERRLFFVGLTRAQQHLYITADFFRPSIFVQEIMQSPLVTKKDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNG4</accession>
    <name>A0A8B7ZNG4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein transport protein Sec61 subunit alpha-like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110987733</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106440.1">
        <property type="nucleotide sequence ID" value="XM_022250748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNG4"/>
    <dbReference type="GeneID" id="110987733"/>
    <dbReference type="KEGG" id="aplc:110987733"/>
    <dbReference type="OMA" id="WARVIMA"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022106440.1"/>
        </source>
    </evidence>
    <sequence length="475" mass="52327" checksum="FD2414DF17D2B31B" modified="2022-01-19" version="1">MVKFLEVLKPFCAVLPEISKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVIMASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITVGQAIVYVMTGMYGDPTDIGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNVCETIVWRAFSPATVNTGRGTEFEGAVIALFHLLATRSDKVRALREAFYRQNLPNLMNLMATLLVFAIVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSTLVSNLYVISQMMAVKFSGNFFVNLLGVWAEAGDSGPHRSYPVGGLCYYMSPPENFSHMAADPIHAVFYIVFMLSSCAFFSKTWIDVSGSSAKDVAKQLKDQQMVMRGHREKSMIHELNRYIPTAAAFGGLCIGALSVTADLLGAIGSGTGILLAVTIIYQYFEIFVKEQSEMGGMGSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSB3</accession>
    <name>A0A8B7ZSB3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RING finger protein 207-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110988860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108463.1">
        <property type="nucleotide sequence ID" value="XM_022252771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSB3"/>
    <dbReference type="GeneID" id="110988860"/>
    <dbReference type="KEGG" id="aplc:110988860"/>
    <dbReference type="OMA" id="QASCHEV"/>
    <dbReference type="OrthoDB" id="6118444at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16579">
        <property type="entry name" value="RING-HC_PML_C-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="111"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022108463.1"/>
        </source>
    </evidence>
    <sequence length="454" mass="51081" checksum="D4D9C4281689A34A" modified="2022-01-19" version="1">MHRISTKLNMASNVTVQSVLTKISKDHLECSICSCRFKEPKVLSCLHSFCLKCLQKLRQYQTTGSTKLTCPICRCDTKLKGNDVATLPNNFTLGALVEEFTMQEQLLEGQGSEIKCQNCEEGKDAISRCSDCESFLCLECNKAHGRTAKTKHHKVNTLEQLRSGEISHRCKLREQFHSVKPSNKVPSHLPKRCQKKAQIHKFGKHPTKFEWASHVAVFSNNEVVIVNLSCDNLISFLPKSPQSPAVSEEIEIDGLHNPRRVAVTKDDELIVMAGPIIKTFERDYTPLNRFKPGRNSKRYPSCLAVDDNNLIAVGYEKNEQIFLHNWDGTFIKKLSAPGIGDYLATYKQHLIYTDRDMHKLKSIDYYGRVVFSTDIHVTDSEDSSAAGVCCDKDGNIYVAIQMFSESDEIHQFSPDGQYIGRVIKGFDHVRGITLAPNGDLVVAEETSVVVCRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTI9</accession>
    <name>A0A8B7ZTI9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gamma-glutamyltranspeptidase 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110989082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108893.1">
        <property type="nucleotide sequence ID" value="XM_022253201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTI9"/>
    <dbReference type="GeneID" id="110989082"/>
    <dbReference type="KEGG" id="aplc:110989082"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000002">
        <property type="entry name" value="glutathione hydrolase 1 proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055262">
        <property type="entry name" value="GGT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="441"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="493"/>
            <end position="494"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022108893.1"/>
        </source>
    </evidence>
    <sequence length="611" mass="66291" checksum="3AA560AED393C81B" modified="2022-01-19" version="1">MPDGTSSTQQLATLDMEQVHIKEKSKVWIWQVAFALLLIVAVGVGVTMGLLYYYKDDNAVAVTPQPSQPPPQPTGEYQYAKAAVAADAGECSEIGRDIMTRGGSAVDAAIAALLCVSLHNCQSMGVGGGFFMVHYNARTGNADVLDARERAPLAAFETLYENETDDASTLGGLAIAVPGEIAGYWTAHQRYGVLPWSDLFQPSIKLAEEGLVVGAALARAISARESVIKADPSLSEILLKSNGEILREGDRMTNLKLAETFKKLAEGGEDVFYRGDLGDDIVADIADRGGIITKEDLKEYKVRRKEPLMVEIGDLKVYTPPPPSSGAVYSLIMNILEGYGIGPDSIATTEAEILTTHRMVEAFKFAYAGRSFLGDEDYVDVREIVANMTLQSYADSLRAAISDNESHDPSYYTAYYNQPDSGTSHLSVVDTHGNAVAVTSTINLFFGSKIRGNRTGIIFNNEMDDFSRPGQPNFFGFPPSVSNFIRPGKRPMSSMTPTIAVDRDGGVRLVVGASGGSRIPSGIVQISADALWYGRNIKESIQRRRIHHQFIPNNVTYEPGYDQAIIDGLRAKGNYPYESTRGCVVQGILRDNQGFLNAYSDDRKGGYPAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTZ8</accession>
    <name>A0A8B7ZTZ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 187-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109043.1">
        <property type="nucleotide sequence ID" value="XM_022253351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTZ8"/>
    <dbReference type="GeneID" id="110989174"/>
    <dbReference type="KEGG" id="aplc:110989174"/>
    <dbReference type="CTD" id="8269"/>
    <dbReference type="OMA" id="PFYLAMP"/>
    <dbReference type="OrthoDB" id="5973769at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028066">
        <property type="entry name" value="TMEM187"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15066">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15066:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15100">
        <property type="entry name" value="TMEM187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022109043.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30869" checksum="CD95A0250C650397" modified="2022-01-19" version="1">MLVISTLLTVVGCTALMVIIVFQGIFSPAKVDLGHEHYGEKADFAIGPFKLPAWMGFAMPLNALVNAGYSLVGLAWVLRTYLARRRGEVGELQAYFAYTFAWMCILYGPVQFWRIISQTHESAVLDQWVTLPFFAWAILWCKALTVGWNREVTAMLMLSSILSYNLVFFTEFGFEIALVIHSVHTASTGFATNRQYPCKGNNFALFMCGLTYVNFVVFKVMDLHLPHYSEFFTEVSGHFISKLFGDVALGHFAFLFFENLAKKQQVESSKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUP9</accession>
    <name>A0A8B7ZUP9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110989302</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110989302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109288.1">
        <property type="nucleotide sequence ID" value="XM_022253596.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109297.1">
        <property type="nucleotide sequence ID" value="XM_022253605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUP9"/>
    <dbReference type="GeneID" id="110989302"/>
    <dbReference type="KEGG" id="aplc:110989302"/>
    <dbReference type="OMA" id="DAKNTHK"/>
    <dbReference type="OrthoDB" id="10094499at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022109288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109297.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="51295" checksum="E765A8BC83E41E04" modified="2022-01-19" version="1">MHMKSRQPAGSKTPTDSKPKWFEDAKNTHKHQAKYLGKILSMKESLAREEQQRQQQAGGLVSRLKNSGSSGMADPGTATSYNQVSSTNPGFPNRGAKTKFREMGKGRSPPDLYPIDIVQGKAMFDKGSNPLQRDKQNKWWRSGSLEERHLIKRSSKDMPKILPPMATIPSVDRRSGYCEKLKSYSATCTGSKVTREEPERDKMIDLKMPVKKSAKAFSHMKGANKTPGKLCKTRPSDRPLRRTQSLDFRCELAPVHPTANMDTDISAQSCQQGRHRSNTGDYARKGSTYVLTKQSSLSELMDKMEVLEGAVGGAADAMEYSDGGCVATATNDEPMIPDDMLNCVPLSTVDRDEHRVSTQSRGGNVRSLLEVSNQSLLELPSSEQHSLLQRRHTLPIINLRPPTPRLTDRDEKTADDQMGRILRKVVCQSVLRKRELSKLCEDIEEFNEINTVLSGHLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUU1</accession>
    <name>A0A8B7ZUU1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Gamma-glutamyltranspeptidase 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108862.1">
        <property type="nucleotide sequence ID" value="XM_022253170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUU1"/>
    <dbReference type="GeneID" id="110989061"/>
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    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="512"/>
            <end position="513"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="534"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108862.1"/>
        </source>
    </evidence>
    <sequence length="632" mass="68992" checksum="F86D4A14C15416F7" modified="2022-01-19" version="1">MFKTTNRKDQQLDRKSEWGKHRALALLLTVAVVVLALIVNKSHLIRDAVWLTHIGQRPSPIGWYRRGAVATDIGLCSEMGRNILITGGSAVDASITACLCLGVASPQSSGLGGGLFMVVHSKNGSTETIIATEAAPAASHFDMFVNDTDQAKFGARAVSVPGELAGLWTAHQKYGVLPWRDLFAPVIDMAQNGYPIAWHTARCLKNLRKNFDRWPILRELYTKPDGSLMKTGDIFTPPASLVQTLRAIADEGMSVLYGGEVGRKLVHDIQEQGGIMTLEDLTSYNVTLQAPVVLNMREGHQRVMSTPITSCGNHLLLVISILDECDLATLDFSSYEGKLKLYHYFIEACTFVTGLRLHNGDFSKAENDKIIAAISSKEYARSICSMINDTYVTYPSGQDYDTFNDLPGTASPNGRVNKATPGPNVNQAADGEAWDKMFSGDVMDGDSSHLSVYTEQGDAVSLTTSVGKYFGGRMLSYQTGLFLNNHMSNFYYNGRSPRWEANRLVPGARAMSTVSPAIVADENGVLGILGSSGGSRIMSTNAWLILRSLWGNKSSLSEIIDSPRVYAFRSPWKSTIYYEKDFPQNLVEGLKAMGHNMELTSSFSAAQGILVGPGQVIQAHSDRRKRGFAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV77</accession>
    <name>A0A8B7ZV77_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110989143 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108992.1">
        <property type="nucleotide sequence ID" value="XM_022253300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV77"/>
    <dbReference type="GeneID" id="110989143"/>
    <dbReference type="KEGG" id="aplc:110989143"/>
    <dbReference type="OMA" id="NCESAEV"/>
    <dbReference type="OrthoDB" id="10540008at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108992.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="42332" checksum="CF4C40833112FF29" modified="2022-01-19" version="1">MSVNFWNCESAEVSSNLISLVWSYSWVCATMNPVVVAVTVGLSLVCLTGQFGTEASAAAIIVTPPGVCVSPGEYFQLKWTAKRAHPTDSLQVHCERQNGERITIDGPSSNFTTASTRCCDAETACVLETTLTGVASGDSGFYWCVASTDGEATLHSASNVPKAYIWVSNVTVFSLSEHNKLITPGLSESITFELKCDFSGFFEVWADLENGESRQLEHIWEWEDRSSDGAPFIQGKAGQRPVLVFPSPRCRDQGLYRITYRASRFYKPVKTVRYLRITVNDTCSELDKKIKTSPTTSSKITTNDAVSKNERYSPANDSATRCDASQRDNSETKGYIFGLGIAALLLVLLLLACGYLFYQNRRLKAVGMGQSDTNDETVMEPLNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVK4</accession>
    <name>A0A8B7ZVK4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">G-protein coupled receptor GRL101-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110989394</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109449.1">
        <property type="nucleotide sequence ID" value="XM_022253757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVK4"/>
    <dbReference type="GeneID" id="110989394"/>
    <dbReference type="KEGG" id="aplc:110989394"/>
    <dbReference type="OMA" id="DSGCWTI"/>
    <dbReference type="OrthoDB" id="1416801at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000343">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="249"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022109449.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="66339" checksum="6FD0D92156264D7A" modified="2022-01-19" version="1">MLCDGKADCIQFGDDEDNCDIHGRPDGCESFMVKEILGVKCKQGWNTTTIHQLVKRTYSLELSGANVGTLGEGLFRRLILLRSLSLRNNNISQIKLGAFSGLGNLTALDLSENNIEEMHGGIFSELKTLLALAIRSVPVQYVRANAFAGLTHLQKLVLMRGNGTVSALSSSQYDWPIEFEDQALEDLTSLHTVYVDDHRLCCDFRSVLPSDDQCISIRFQSPLFNCGRLMPKTVLQVFMWILGCSALLGNMLVIVWRMREDSGKGSKYVHSFLVLNLAMSDFLMGVYMVIIATVDAIEKEKYYLTATQWRNSALCKAAGVISVLSSEASVFFITLISVDRYLCIVHPFSRVRLQETSVWVSVASIWLASLVVSLVPTILATSDSDIYGLSDVCIGLPLLTRPVDYTFTKDDVGGSLGNDTYLIPQPVGSRPTWSYSIVLFLGVNFMCFLVITVSYIAIFAKVKRSVRRVKLRSHKAEEIKMASKMAVIVGSDCLCWMPVIVLGILSQTSVIQIKPEAYAWLVVFVLPINSSLNPYLYTIVTAISQRRQAHQSTKKRSKGPEKTCSPDLPMEMRGDSGCWTITTPNATPTNSIYHGHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX19</accession>
    <name>A0A8B7ZX19_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3 4">Branched-chain-amino-acid aminotransferase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3 4" type="primary">LOC110988656</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108084.1">
        <property type="nucleotide sequence ID" value="XM_022252392.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108085.1">
        <property type="nucleotide sequence ID" value="XM_022252393.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108086.1">
        <property type="nucleotide sequence ID" value="XM_022252394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX19"/>
    <dbReference type="GeneID" id="110988656"/>
    <dbReference type="KEGG" id="aplc:110988656"/>
    <dbReference type="OMA" id="EMPRRDQ"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022108084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108086.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34522" checksum="71218D813FC52434" modified="2022-01-19" version="1">MSGNHHKHAGASQVRLLVWAVPRSLSTVLTKCLSFVEDSLVIFEPYFCAYLLGPQRFVPEVLDAVEEVGLANYEKEAAELTSVKGGFEASECTYEWAREQLEADHVGKRFVFCKDIASAVIIGDKLEFLPRDYRHVFLIRHPLRVFPSMKEMIRLTERASHDFSLDEVKRFPTYSMFRDASDLSDHIRKEQKQEAIIIDADDLQQDPRGVLSALFTAIGMPFQERLLNWEAGDAVSRSWFISTTQLRGNQIGQYYKNAFASTCFLRPSALPDRESLSADILRCVDASMPYYKKMYAQRLKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXZ9</accession>
    <name>A0A8B7ZXZ9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110989503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022109630.1">
        <property type="nucleotide sequence ID" value="XM_022253938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXZ9"/>
    <dbReference type="GeneID" id="110989503"/>
    <dbReference type="KEGG" id="aplc:110989503"/>
    <dbReference type="CTD" id="4338"/>
    <dbReference type="OMA" id="WKHQFFA"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000002">
        <property type="entry name" value="Molybdopterin synthase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="103"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022109630.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16714" checksum="5A1533F037D1BBDD" modified="2022-01-19" version="1">MEGKDFVQITSDPLSVEKATAMVSSPTSGAISIFIGTTRNNFEGKEVVRLEYEAYVPMAEKKIGCICRDVREKWEVEHVAVFHRIGVVPVQEASVIIAVSSPHRQASLEAVQYSIDTLKATVPIWKKEMFAEGRGRWKENKECNWRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYI8</accession>
    <name>A0A8B7ZYI8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid-binding protein 2, liver-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110479.1">
        <property type="nucleotide sequence ID" value="XM_022254787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYI8"/>
    <dbReference type="GeneID" id="110990019"/>
    <dbReference type="KEGG" id="aplc:110990019"/>
    <dbReference type="OMA" id="KATPCWE"/>
    <dbReference type="OrthoDB" id="9991853at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00742">
        <property type="entry name" value="FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14651">
        <property type="entry name" value="Lipocalin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022110479.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14263" checksum="7D03DFFDC864B8A3" modified="2022-01-19" version="1">MPCDLSGKWVYTSGEGMVALMDKLNIPADKRPSDPSSTVEITQNGDNFCIKTTTPDGRSREAKFTIGVEFVDEEIKALRGMDIKATPCWEGDKLVLKGSGGNGSVSRQIVGGQMVLTYDVMGVKATRVFNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYK4</accession>
    <name>A0A8B7ZYK4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">RING finger protein 212B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110990029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110494.1">
        <property type="nucleotide sequence ID" value="XM_022254802.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110495.1">
        <property type="nucleotide sequence ID" value="XM_022254803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYK4"/>
    <dbReference type="GeneID" id="110990029"/>
    <dbReference type="KEGG" id="aplc:110990029"/>
    <dbReference type="OrthoDB" id="2535391at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16560">
        <property type="entry name" value="RING-HC_RNF212-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="343"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022110494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110495.1"/>
        </source>
    </evidence>
    <sequence length="393" mass="43545" checksum="8DD7AE2253358EC8" modified="2022-01-19" version="1">MMADWVHCNQCFLQPGGGKKFFLTNCAHIFCDGCIQEGSKNQCHTCGSHCTTIELSSKMKPDVEIFFQSPHEIARKQHKQLMQVMDFQRNHSQRLAAYKRDQEAKMQSRMQMTVRQLDQARDLEREVLRLQEENCKLRRLVSGSPGPGGAAKVYRSSTPGQVLANSSIPPKVRNMVHQNSSQSISRSSSPYGRSQHIQQMETSKTPQSQPMTPTRTPPGPARLSIRTPPVNGRIGESTSLGPEQTRTHPIWTRFQQPQRLTTYQGLISQNLSFIFSTVHLFSGTVGTPTQGNMTLTPSGTLIRSANTPGAVVGMATPGRSSPMNVSPASNSFSSFSNFRSSQLHNDCSQGSTRFSLSQSSQSDQARRPIQLNYTPKTPTRSAAPVSQYRQGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZD9</accession>
    <name>A0A8B7ZZD9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein LOC110989114</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110989114</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108951.1">
        <property type="nucleotide sequence ID" value="XM_022253259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZD9"/>
    <dbReference type="GeneID" id="110989114"/>
    <dbReference type="KEGG" id="aplc:110989114"/>
    <dbReference type="OMA" id="PECWYWE"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056047">
        <property type="entry name" value="CRMPA-like_DUF7630"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051432">
        <property type="entry name" value="KCNMA1_auxiliary"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473">
        <property type="entry name" value="GH08155P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46473:SF10">
        <property type="entry name" value="LD45603P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24633">
        <property type="entry name" value="DUF7630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034675116" evidence="15">
        <location>
            <begin position="20"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="909"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1053"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1084"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1117"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="16">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="978"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="986"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022108951.1"/>
        </source>
    </evidence>
    <sequence length="1199" mass="135519" checksum="FC7065E2C3E367B5" modified="2022-01-19" version="1">MRFQYTGINMLVTFRAAVSTVLCVALVNSVRDACKVCKCSSHGPLIVNCTRKGLTELPSRIPNETRVLILDGNFIRFIPYRGLLGLKSLVVLQLTNNSIKAPFEIPKSVVKLSANWNGLQDIRPIMRNGVNLDFADFSNNALKVIQTDTFKNCTKMLTLSLGLNNISTVQHAGLSGPKYLNNVRLQGNNLEDIGPSATAGLHCRSLWMYKTKLRHIQPHTLAGVKRPNLSYNMLKDIPSAVFADPAAPTPRNLLEVNFRKNLINHISERAFQGVRTITVLTLQGNKLSSLPEHLFANTTISLTLNLASNQLTTMPDGLLRSQSMLKHLYLQQNRLTVLNEHMFKGLRSLTDLMLFDNPLIEVADWAFYETQLTRVYIFQTNLTVLGRRPFATVNDTIKLMSLYGNYFETLPDALWQDLATNCYVSVDNTLKFAPSTNRTDIEIELVRDGFAQPINLTKDDGKMLTKTGFECYPLHNTDIWQCKPCPQGFFGASWSGVCIACPPGGFFQNQTGQLVKGGQVMNCHKCNNGTFVAPSAQPGKRPADCKVCPTGTIKSLHAGFRACPCVDNYYRTDRFGECYPCPTEGLNCTEEYQHLLPGFWWTWNWGSDGNRRSYEQFVQNLRTENASYDSFSQVFLGTLPRVHACPRPESCAVEGYGIRVTCQTGYEGWLCSRCSKGYYARLDNCLECPKWQWFLLEAMAVLLVVAVLIVVIVWDLRRNRRSGRSVVDKLLARAKILLGFYQVIGEIFSALEEIQWPDLLKSFGSVLHFLEVDVMRIVISPRCYFPDFTYPDVYIEFIFGFAFVAVVFCAALCFYGVTKCYHVAKETPVLDMTLALTKARQRCYLFVVMLLFVSYPSLSSVILTLLPSSCDLFYLDEHHMFNATRLRFDYSIDCKTSRHVHFTHAAEVSLSYVIGFPLLLFVLLWWSSGPWRILRRFAFMLCGCENGNASSDCNMACEEQSLPFLQGWEGVRNRRGINASNGQSDLDGRTTRRQSDQTVEHTTTGQHNTEGVTWKTFLCENYKPQFWYWEIIELVRKIVQTVFVLLFGYEDPFTMLATIVTSVVFLLIHSSVRPMKDDSEHRLQLFSLGTIFLNLLVASLLLLPANEDPSSEKRKEVLAVTLVLLNLSLIAFVLFSFMWSCAKAVWRQGCCGGVGARITELCRQRSRPAASRCDHEGDEDDDELQSYAEIQYSDIANAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A074</accession>
    <name>A0A8B8A074_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dual-specificity kinase</fullName>
            <ecNumber evidence="3">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110990198</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022110757.1">
        <property type="nucleotide sequence ID" value="XM_022255065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A074"/>
    <dbReference type="GeneID" id="110990198"/>
    <dbReference type="KEGG" id="aplc:110990198"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14226">
        <property type="entry name" value="PKc_DYRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000117">
        <property type="entry name" value="dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044131">
        <property type="entry name" value="PKc_DYR1A/1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="204"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="525"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="673"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022110757.1"/>
        </source>
    </evidence>
    <sequence length="818" mass="89168" checksum="C4AC5DD67DE197AA" modified="2022-01-19" version="1">MVQQGLGGTGSGMLSRDSSASWRKSEGSPYLPVNPLAVASRRRVNGRRPTAKRYTLTTANGYHDDDLGGEVPHRRHHLEPPDMAAAGPGSLTNHVTRSSRPQPGSFEEQSYVASQKEEMAAMQSRIPQTFRDASTAPLRKLSVDLIKTYKHINEVYYAKKKRRALPTQGDDTSHKKEKRLYNDGYDDDNYDYIIRNGEKWEDRYEIDSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQIEVRLLELMNKHDTDCKYYIVKLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIPYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIIEVLGMPLPHIIDQAPKAHKYFIKSDKVWVLKKTRDGKKYKSPGSRKLHDILGVESGGPGGRRAGELGHSVSDYLKFKDLILRMLEYDPAARIKPYNALQHSFFKRTADESTNTSNTPSTSPAMDQSATPPTGDASSGSSSGGVTGGSRGSGSGSGGRARSDPSQTNTAGSHQGGSHHALQHAAAGSGSMDYEPSATHGTAAASSQTWAAGDGNAFGARPNNSAHGHFHGGYHSHGHSRKHHPHHASPSGPSGAVTQPNAISVPQASQNPVTNLSSGAPQHAHYNAVDATPGPGYVYHGQLDCTQSGSLNMQLAGYGGNTHSLLGSHAHPTSGSNPHIHGQSATNANINYAAAVGTAPYGYSITGQAPVNPVLVTTQQTSLQGDESPMMGVVQQSPVVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0C5</accession>
    <name>A0A8B8A0C5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110990228</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022110807.1">
        <property type="nucleotide sequence ID" value="XM_022255115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0C5"/>
    <dbReference type="GeneID" id="110990228"/>
    <dbReference type="KEGG" id="aplc:110990228"/>
    <dbReference type="OMA" id="YAWLRIN"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF22">
        <property type="entry name" value="VERY LONG-CHAIN ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="68"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="516"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022110807.1"/>
        </source>
    </evidence>
    <sequence length="636" mass="71237" checksum="31238095AD577AFC" modified="2022-01-19" version="1">MSGIPINRRMLGVAAATAAGIPFAVAGFLRLKYGATIFADLLELCKRLRTIREIETLLSKNVRVIDVFEAHARRIPDKEFILYKDEILTYAELDRQANQLAHFVQRSEVAACMNTVAIFMQNEPTFIVSWLAFNKVGLRIALLNYNLKGDVLLHCIKACSMKMIACGNDDRLVKALADLMPELKALGAKVWVVGNDLDQDLPLGMIPVDVKTLNESSDPIPRSVRDQQRAQDDALYIFTSGTSGLPKPAKCPHTQQLIGSYMQASLGLNSVDVLYLSLPLYHSAALIVGFFNVVRVGGTVALSDFSARRFWDDVSRYRATVIQYIGEICRYLAAQPTRTDDGKYPHKIRYAIGNGLRPDIWVEFQRRFNIGHIAEFYGATEATYATINLDGKVGSAGRYHGLFRALTDIIVLVQCDIETARPLRGPDGKCILTPPGETGLMLFRLTDETAFHGYLAKETETAKKLVRNVKKNGDLFFNSGDLMVHDKDGYLYFKDRLGDTFRWRGENVATTEVALVLNQYPGIDESNVYGVKVPGRDGRAGMAAVVLKIEHRLDPKAFYDHVVRSLPSYACPKFLRIMEKMDITGTFKHKKTDLAREGFDPNVMSDPLFFLDEEKKTYAPLDKDAMRRIVIGQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A145</accession>
    <name>A0A8B8A145_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990394</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
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            <taxon>Valvatacea</taxon>
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            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="F:glucuronokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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            <begin position="32"/>
            <end position="214"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
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    <sequence length="382" mass="43440" checksum="FAA7FB83FE94B11D" modified="2022-01-19" version="1">MICVILVAGHGRVLEDEIKNDVSGRYSSLEGVPKSLLPGVGGKRILDFWWEAINTRQVFSDVYLVTNADKYKYYERWATANDFPVDNIVNDGSTTYENRLGSVGDFDLVLRNKRIDDSVMVVAGDMLFQDHNFDITQVVDYFKRKRGELAIYYEMEPTELSRSRGIVDVCPTTNRIMHFTEKPSQDETASRMASVVFYCFRRQTLSTITAYLDNHPDVVERNFGMYMEWLVNRSGIEVYGMKLPTGFQLIGQVGLDEYKKWLGYFSDKQLQQGIKEPFTATGHARVGLMGNPSDGFYGKTISLSIANFWAEVTIKESERLILVPHPLNDPTEFGSLGDLHGISRKEGYLGGLRLLQATCKKFYQYCSEQGVLLEAVPLSRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A392</accession>
    <name>A0A8B8A392_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990645</fullName>
        </submittedName>
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        <name evidence="3" type="primary">LOC110990645</name>
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    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
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            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_022255723.1"/>
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        <location>
            <begin position="170"/>
            <end position="256"/>
        </location>
    </feature>
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        <location>
            <begin position="170"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111415.1"/>
        </source>
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    <sequence length="256" mass="27243" checksum="B3F49CF1BAFC8E00" modified="2022-01-19" version="1">MPKIRVPVIEDRCIDEAEGPVNVTWDEVTAIDTAPENITCTESVGGTNVSLTGGVFGVGCYVVTCRIVLPDGKIVSANFSFYIIAIPIISVPEVEVQWIVCGKASILVTWDKVNATNADGNPINCTSDTGTNVTVTGGYFPVGSHTVTCSVTNGWGCFSSANFTFDVIESTTTPEPTTTPEKTTLEPTTTMDSTITSEPTSTLELTTKDSSTTREPTTTQEKTTLEPTTTMDSTRTPEPTSTLDLTTKDSSTTRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3W5</accession>
    <name>A0A8B8A3W5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110991164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110991164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112072.1">
        <property type="nucleotide sequence ID" value="XM_022256380.1"/>
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    <dbReference type="KEGG" id="aplc:110991164"/>
    <dbReference type="OMA" id="MQYICEI"/>
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        <property type="component" value="Unplaced"/>
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        <property type="match status" value="7"/>
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        <property type="entry name" value="C-type LECtin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
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    </dbReference>
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        <property type="entry name" value="C-type_lectin-like"/>
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        <property type="entry name" value="CTDL_fold"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="7"/>
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        <property type="entry name" value="Lectin_C"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034907206" evidence="4">
        <location>
            <begin position="25"/>
            <end position="3472"/>
        </location>
    </feature>
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        <location>
            <begin position="3320"/>
            <end position="3340"/>
        </location>
    </feature>
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            <begin position="25"/>
            <end position="134"/>
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            <begin position="629"/>
            <end position="748"/>
        </location>
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        <location>
            <begin position="760"/>
            <end position="856"/>
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        <location>
            <begin position="868"/>
            <end position="980"/>
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    </feature>
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        <location>
            <begin position="992"/>
            <end position="1083"/>
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    </feature>
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        <location>
            <begin position="1096"/>
            <end position="1212"/>
        </location>
    </feature>
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            <begin position="1224"/>
            <end position="1314"/>
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            <begin position="1317"/>
            <end position="1432"/>
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            <begin position="1442"/>
            <end position="1555"/>
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            <end position="1692"/>
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            <begin position="1809"/>
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        <location>
            <begin position="1930"/>
            <end position="2048"/>
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        <location>
            <begin position="2058"/>
            <end position="2150"/>
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        <location>
            <begin position="2163"/>
            <end position="2271"/>
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    </feature>
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            <begin position="2293"/>
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        </location>
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            <begin position="2396"/>
            <end position="2514"/>
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            <begin position="2526"/>
            <end position="2617"/>
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            <end position="2844"/>
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            <begin position="2856"/>
            <end position="2972"/>
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            <begin position="2984"/>
            <end position="3075"/>
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            <begin position="392"/>
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            <begin position="3078"/>
            <end position="3105"/>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_022112072.1"/>
        </source>
    </evidence>
    <sequence length="3472" mass="386669" checksum="08C6171DC99E01C8" modified="2022-01-19" version="1">MGQLLLPCFCFLLVLCIGTPSITACFAPLDLSGPLGNVSTPDYPDPYPQEYDCQLINITVSQGQIISLKFDGFDLGDDDVLMITEPSKPDPLILRGGRLPKNYYSHENTLQLNFTSESYNVDNRTGFLVYYTESDRVLPTPKTRVVPYTLSPGRPTVIRSLDYPQSYGDFAFYFYTFTSAPNTRIWAEIMDLDTEEGFDFLEMGNGVDPEQRFATRMRRVSGRGSRFQSMLSENNEMWMLFESDYSVVGRGFSVMLYETSLDFPDVKNLTAVPDNVTCGDSVNIPESGSISVQLTNYANNSLCTWRVSGVAGLRIRMSPNLFSLENGFDVLEVGNGLDPMDQSSRFVSLTGNGPSGPVMLESDAVWLRFRSDASVSDQGFQINFDQPITTECGGEFYINETHPSFIVAVDGMVLPMMQCRWIIRGRPGHFISGNVTRFKMEDIYDMVEIGTGDNPADPKTRVKMMSGNVDGGKFYTIADTVWVVFTLNGTQAGEGFSITFADDACGISTLLDRQGTIQSPGYPLGYPNNADCQWIIQVRGGYRINLTVNDLRTEYGFDKLLIGGVEPQDSGWSPCYELTGDMMKGVSVLSDYNGLSLRFVSDGSKQDMGFSVSYEETFFCPEGYELGNNDSACYKFVLAPASWEEARDECLGVDDGDLLVINDEAEFEYIKEMSFNISGDWWVGWYDRAIEGQWSWVDCQASTDWANSKWSNRSFEDAGMEEDCGMLLGDSGLLDDKNCSLPVKFVCETTKKDYAYTDAFPSLIRGQSTSEFSILLSWRVSSLVCDLRGYQIRYNTTASMDQFTYIDVDDPMANSVEVTGLMPDTKYLFEFVIDTFSYGLSSYRTAKSVFASTAKCPNEFEPGPADICYKFVKKLVTYEEARDDCQRTPGGDLVIIDNPTEQQYIQNRSVDGDWWIGLNDRAVEGRFRWTDCSPLTIWQSTQWAPDQPNNLTDSQDCGQFLETGQWNDWPCDRPMQYICEIITKNFDPENVSPGQFSATEVDPFSIQLSWVPPLYNCDIKGYAVMWGRVGDPLMMLQIEGVETSEYLVGNLLPEETYSFQIAAETFRQVLRFSSPQNVTLSDSTGYCPGGYEVGPMNNTCYKFVKKLVTWDEARMDCGSVRDGDLVIIDDVMEHDYIMERVVDGDWWIGFSDRGVEGRWQSVNCLDLSPWQTSKWAPDQPNDLSGTQDCGQLLETGQWNDWQCDRPMQYICEITPKAFNPEEQVATNLTVVDFTSTTVTLGWLPPPYTCDVLGYRITYSTSLSIYTLDVEGGDTSKVVVGSLRPLSLYSFNIQTKMAMGSSEPSDPITTNTAAYEGCQDVISSTDAVGNITSPLFPDDYPRLVNCLYRVDLSSSVGADSRIRLQFVYFSLGADDYVEIRELDSSARNYGTPVVIKGRGPIKDYFSSGSSLDIQFVSDASAEARGFRILYSQSEAAQPAEKDCGMTYTVKTNSLLSFQSVGYPNRHDNYQSCTWVFTCQPDKVLFAYLLQAGLEDGYDWVAVGNGNDPTNETALLERFTGQATGLILFSEDNMMWITLYSDYSISGMGFSFLLEEIDPSEVPVPPPKTQRSHDFGIQATCGGDVLVPTDGKAIITSPNYPGEYDINTTCTWLITGIPGRRFQMIFDFFETEKNYDLLSVGAGLDPLDPTSLRTAVSGSSLPSNIVLASDTAWVEFTSDSSTIGNGFSISLQNGNDCELILTVPSGGNMTVESPNYPNVYPNNSYCFWTIVSQSGRPLRGDVIRFSTEDGYDFVDVGVGNQPADLSTRFIHTSGSGLQPFSANSSTLWMTFTSDGTNNAEGFQVVFLDDGCDDSIIENTTSGRIESLNFPNTYPNNLDCTWTIRVGEIFRVKLVFEAFNVESGYDKLIIDGVDGDGSLTLTGSNLPDDVLSATNVITIQFQTDSDGGASGFALTFEEIYYCPGGYVAFQVGEGYTCYKFSADEKNWIEARKDCQSTDNGDLIIIENALENRGIAEITGGLDWWLGFYDRANEGVWRWVDCQAPTSWGNLNWEDPSGPDSTNGDEDCAIILDSSGRYQAIPCETPRRYICEIGEPKIFDGNPVSVSGFSFTSSSIHLEWTLSPQRCDVLSYFVQYSTLSGSPVETIVTGSNTNELDVFDLVRGTSYFFSIAAVTFTSGKLAYTDPVEIQTLQFDSEFCPPGYQGGWNYQCYKFVLSPVTWDEARADCRSVENGDLIDINFYAELLYINETAPGETLWIGYYDKGIEGDWRWSDCELPNAWQAINWAPDAPNDPLGNQDCAELTPDLLWDDQPCNGNVINGYVCEIYTKGYNDTDQNPTEITGEALTATRVSLTWTISIRFVCDVLGYKIEYSFDDQEPKIQRVDGASTGRAVVEGLVPNKNYTFLISAYSSLGDVTPTASVSVVTPDGDLCPQGYQEGYDYGCYKFVTSVKPWNESRRDCQSTEDGDLLIIDSQAELDFITQAKENISGTWWIGFSDSAEEGQWRWVDCSAPSGLNGTYWADGQPSDTTGTENCAELTQDSKFNDLACTSQLMYVCEITRKEFFPSEVDPTNFLGVSTTSESVLLRWTVSDYNCDIQGYKIQYRMNQGPEQQEIVPGSNTNNVNITGLMATTEYAFKLLAYTEFGDRGVAGITNVTTQEDPNACPEDGWEVGHGGKCYKFVRQLETWYDARAVCKQDADGDLVIIETQEENLYIQDRVQDGDWWIVSVEGDWRWVDCSTPSPWTLSNWGEGQPNNLNGNQHCGQILNDGKYNDWQCDRTMQFICEISPKPFDPSDGNPSRLRVFEDTPNSVLVQWRPSLVSCDVIGYRIAYNDPIVTNFKEVQGGNISSVVVTGLQDGSTYFFSIAGFTQEQLLPYSDRVSIVTPPLDDLCEDGWEPGLDYKCYKFGLLQKTWEEARADCQKVTDGDLVIVETQEEHSYLVNRTLGGDWWIGFYDQGTEGDWRWVDCQVQGTWPSTNWGNNQPNDLDGSQDCGQMLQTGLWNDWNCERPMQYICEINPKGFSSEDQGPTLFRGVAIDPTTIQLAWRPSQYNCEVLGYRIVYEEENVGKTLIVEGGATSSVLLKSLSPGAVYVFFIGAFTKDEELDLEGRSVRIQLPQGGVCGKRDLTASSGTIASPNYPSAYPANQDCIFTVSLPDSGASILIEFTAFDLEKGHDFLMMGPGLSPDMDTQYSLTGSELPQMAMIESSRAWIRFFSDESNQRLGFSLMYSTAKADSSGENIGSITLVLISQSFESFNEAIQTEFATAVVNQLNIYCKLDETNCLVDSTAEFTYREIRFTSLQDVDEGLQVTFWVTDPNDPMRRQAGLTSYQLQVVLDEYKANVENGGQFQFVVRTESNPLSEPWVIALLCVLGLLVLLLLVVIARDLTSRRKKKPRSLSSSDVEMKSREDFMTTDDAELIANADEVSLSSEQRRIPSAVNDNVYYVNPNAASHETEVGLGSLGASSNKGILKEEVSDPKTEVTGADDQKEGINGNIEVQVEPEPLYAATTKQSLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A429</accession>
    <name>A0A8B8A429_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tripartite motif-containing protein 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111680.1">
        <property type="nucleotide sequence ID" value="XM_022255988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A429"/>
    <dbReference type="GeneID" id="110990904"/>
    <dbReference type="KEGG" id="aplc:110990904"/>
    <dbReference type="OMA" id="FNWACGI"/>
    <dbReference type="OrthoDB" id="6267506at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05819">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111680.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="37245" checksum="40B700E6CD73EA56" modified="2022-01-19" version="1">MSLASERIQHSLETAREVTRTAADSEFLSLYATINKDLKLLAGQTIPRVDKKLGFLKFMPSKGVGDICLGKVVTEGKWEQRCVFGRKGSGPGKFNWACGIAARQPDEVAVADCLNKRVVTCSIDGNQKSTIPMERRPRGIAATRTGNRLVVVEENASHVKVFDKDNTLAFQFPTVPPSEVGKTAVNLRSVAVKTDGTIVVGDIKRMVLTEHSPTDGELRSTIPVKIKPRYVAVDSNDRVVISDWEQLVSVVDGNGDTLFTIKPIINGEVVRRCTGVCADSTGIYVAMNNVDDTGHIHHYDPQGGFLHCIAEGLHWPMGITFTADGQLAVTDVYSVKIYDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A5V1</accession>
    <name>A0A8B8A5V1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Galectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110990585</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111341.1">
        <property type="nucleotide sequence ID" value="XM_022255649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A5V1"/>
    <dbReference type="GeneID" id="110990585"/>
    <dbReference type="KEGG" id="aplc:110990585"/>
    <dbReference type="OrthoDB" id="6251307at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000124">
        <property type="entry name" value="Galectin-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044156">
        <property type="entry name" value="Galectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF176">
        <property type="entry name" value="32 KDA BETA-GALACTOSIDE-BINDING LECTIN LEC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034827315" description="Galectin" evidence="5">
        <location>
            <begin position="17"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="6">
        <location>
            <begin position="38"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="6">
        <location>
            <begin position="270"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022111341.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="44928" checksum="E4514DC951BE765F" modified="2022-01-19" version="1">MSSWLVLLNIFWTAQVIRNTLYANMASTVITTNPGIPFSGIIPGNMSPGKMLFIQGYVNPNALRFAVNLACGLRQVPLDDIALTFSPSFGQGVAVVNHFKKMTWGQEIQVQNVLQRGQNFEMIINAEASQFKIALNGEHYISYPHYIKKLQRISHITINGDVRIYTIRMEGGYTPAPVLAAPAHTAMPSAPAYPTGPAPPPQYAPSQPAYPAQPSYPAAPAYPAPPVAQPSFPAQPAYPSQPAYPSQPGYPSQPSYPQGPQVINNPPLPYLQMIPGGMKKGKIITVKLTAKPRPTRFHINFQCGMSTNPRSDIAFHFNPRFNEQAIVMNALRCTRWDGTEQRHRTYFPFHPNGTYEIMFLCEQHEFKVALNGSHLLEFKHRLPFQNISALAIDGDCIITQINYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A6B4</accession>
    <name>A0A8B8A6B4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111521.1">
        <property type="nucleotide sequence ID" value="XM_022255829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A6B4"/>
    <dbReference type="GeneID" id="110990731"/>
    <dbReference type="KEGG" id="aplc:110990731"/>
    <dbReference type="OMA" id="RTTCHRY"/>
    <dbReference type="OrthoDB" id="6145901at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040676">
        <property type="entry name" value="DUF5641"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331:SF1">
        <property type="entry name" value="GAG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47331">
        <property type="entry name" value="PHD-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18701">
        <property type="entry name" value="DUF5641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5641" evidence="1">
        <location>
            <begin position="36"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111521.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13455" checksum="5625E61CF232BEB6" modified="2022-01-19" version="1">MRRVLTEQKCLAFHFKHGSVEEVVIEDCTSNMYTAQWKMVQILADRFWKLWRLRSLQSLQQRRKWISPERNMAVGDVVMLRDKDVSRNRWPLGTVDSVSPGDEGLVQEVHIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A6U8</accession>
    <name>A0A8B8A6U8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Insulin-like growth factor-binding protein complex acid labile subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110990974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111731.1">
        <property type="nucleotide sequence ID" value="XM_022256039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A6U8"/>
    <dbReference type="GeneID" id="110990974"/>
    <dbReference type="KEGG" id="aplc:110990974"/>
    <dbReference type="OMA" id="FFAVINN"/>
    <dbReference type="OrthoDB" id="1111193at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000770">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF210">
        <property type="entry name" value="CHAOPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034176526" evidence="5">
        <location>
            <begin position="28"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022111731.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="42208" checksum="CB07F5D740EB2092" modified="2022-01-19" version="1">MASGSIHRCDLHLIMVVTVTVLRTCAPCPSVCNCTGTFYGNAYCNHKNLDRVPAGISTNTRFLRLEYNRLTRLPAGAFSGLSQLLRLTLYNNLITEIEDGTFSGLVALKKLHLGSNNINLLTNNTFQGVPNLEELSLSNNRLLSLGNGVFNQIPNLLELDVSHNGIREFPTEVSKYLSNVQVLDLSSNPAQLLLIQNTVGIFKQIVALQYLKLNKLSEVSNTAGEIRIPESTFDGLPNLTNLELNGNRLSKIPSAIKSLKNLKYISLHMNSIQSVGADDFHQPSLLEILLLDKNKLVEIPASALAQLPHLTKLYLDFNPISTIPARAFWHNPRLTNLSLAYTNLTTIQEDAFSGLDQLGSLNLQGNNLTTIKGGVMTHVNPKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XH45</accession>
    <name>A0A8B7XH45_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110973161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110973161</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079435.1">
        <property type="nucleotide sequence ID" value="XM_022223743.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079436.1">
        <property type="nucleotide sequence ID" value="XM_022223744.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079437.1">
        <property type="nucleotide sequence ID" value="XM_022223745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XH45"/>
    <dbReference type="GeneID" id="110973161"/>
    <dbReference type="KEGG" id="aplc:110973161"/>
    <dbReference type="OMA" id="TSPEFMM"/>
    <dbReference type="OrthoDB" id="10545157at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="880"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022079435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079437.1"/>
        </source>
    </evidence>
    <sequence length="901" mass="99604" checksum="0200A84F56AD4CB9" modified="2022-01-19" version="1">MVTMSTDEGSLNLYDDEYFMDSLQSATGWTNNPPLITKSQVPSLSTIMELEDKDVLRETEPINTEVWETNDHEPELVLDIELEEGWEKGPRPTAAELASDFEGGAGDGLDENTPSYQSPGFSLRRSWGLASPWHESRSFGRSPRASIMLVSQSVGPGKLIVKRNEKETLRSEDQLAVTSPEFMMYTPAATTPTKRSVLLQTSANSILAARGRKLFARAREINSEQAEDSERIASDASITMIPRPESFFLPTWRERRVVSCRARNINHSSSRSKVFPWQSFSILDETLCFDDEDDVIKYPRDINFRKARSHPSLTFAGHQSAVTTRNVSSSTCLGHDRNGLADHAKCFRTELTPTHFEDDTKTTDAHSTETSCLGATKLPPHQELSNMSKTDVDELSNNVPDSQSSSNAKTETASRGNISQAELTTSKPLPLETIRQPTAPTKTTRKPRLSHVPGSKRTSAHFNNSSESAASKSPVNDTKDVADQQQVDQTRILITGPFHIPHPPPLPRPPRSMPVVPCSKNPKRCPDHSMRQSSEHKGVESSEEWQIARTSFVTLVDQPSKEIKKQHSIRQASIPLSSNEARRELVVSAIHPIPYQPAARSNNQRVVPPISTVASASIPRLQSGTKRGVLPSNVCNWELPCSGKPDAELDNPPGKSAISRPKEQSEKRNILGQKRDSKSNAGARFIKTSLGLSGPIQQRYSFGGTISCQYGSSLGHTSRGSVLQDNACRHQVVLTPPSFRSVFSERPVATGQSVPFDFQASLRKPTVGPMQLARHVPRRLNIHLVPAVELGACWKANLADPPLETRCVPNSFSSVSNQGPISLKPRAQVSKQVQSHVKPLGKSFQVQRNTDTTCTKDAARLYRKTAGKLSFHSAVWETQGVSRRQQSKKTSLTSLREHRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XK86</accession>
    <name>A0A8B7XK86_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110974140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110974140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081218.1">
        <property type="nucleotide sequence ID" value="XM_022225526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XK86"/>
    <dbReference type="GeneID" id="110974140"/>
    <dbReference type="KEGG" id="aplc:110974140"/>
    <dbReference type="OMA" id="RTKQYEA"/>
    <dbReference type="OrthoDB" id="10385251at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022081218.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="38900" checksum="EC648E35F16084B1" modified="2022-01-19" version="1">MSADPDQVTPNEGGFADVPPGQASEEGSGASSPAEPIESYGEEGPEEMKAEIRYLQQKLEDVQGESSLLKEWGARIAMYVDCLVDALETNQITHVYDVDGSLVSLDECRQKAKTLPHTRKPHCDDDLRTKQYEAEIDNLRQEIADLNTSIEETLQRSVEQDYLIEQLQTAEYQANCRWEAYYENAMRQWSKCYENLQGQYNDAVIRLQNLNTAYNSLKKTAAGRNQLGPFNRPDPFRRHRPAAVRRDVGSAGPGQHQQRRPPAASGERMTRSAYQGRDYWGRNDFGPVLPRAERAAILKQFFANLNMIRRRQEEMAGVRWLNRRHEPRRRQRPGPYGEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLP6</accession>
    <name>A0A8B7XLP6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110974035</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081036.1">
        <property type="nucleotide sequence ID" value="XM_022225344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLP6"/>
    <dbReference type="GeneID" id="110974035"/>
    <dbReference type="KEGG" id="aplc:110974035"/>
    <dbReference type="OMA" id="KEACHFW"/>
    <dbReference type="OrthoDB" id="10664001at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.225.10">
        <property type="entry name" value="Saposin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011001">
        <property type="entry name" value="Saposin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47862">
        <property type="entry name" value="Saposin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034594976" evidence="1">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081036.1"/>
        </source>
    </evidence>
    <sequence length="137" mass="15856" checksum="975E5DAEFF3E7554" modified="2022-01-19" version="1">MTNFLGLLILFAVVMSANGRQLQEVFSTPQNGPFLCMWCDMVVTFVRNVSTDRDFLDLLVKNRKEACHFWSPAGFEKYCEDYVNEIPHSIALFADEYLDPAKDCATVCRGQEPDQQHPTALNNFVQKMKSDYEKFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLR2</accession>
    <name>A0A8B7XLR2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12">Tubulin monoglycylase TTLL3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110974043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022081051.1">
        <property type="nucleotide sequence ID" value="XM_022225359.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081052.1">
        <property type="nucleotide sequence ID" value="XM_022225360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLR2"/>
    <dbReference type="GeneID" id="110974043"/>
    <dbReference type="KEGG" id="aplc:110974043"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0070736">
        <property type="term" value="F:protein-glycine ligase activity, initiating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="FunFam" id="3.30.470.20:FF:000032">
        <property type="entry name" value="tubulin monoglycylase TTLL3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051437">
        <property type="entry name" value="TTLL_monoglycylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45870:SF2">
        <property type="entry name" value="TUBULIN MONOGLYCYLASE TTLL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="859"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="382"/>
            <end position="433"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="547"/>
            <end position="591"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="949"/>
            <end position="1006"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1094"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="285"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="296"/>
            <end position="335"/>
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            <begin position="396"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="1032"/>
            <end position="1044"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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    <evidence type="ECO:0000256" key="7">
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    <evidence type="ECO:0000256" key="8">
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    <evidence type="ECO:0000313" key="10">
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            <dbReference type="Proteomes" id="UP000694845"/>
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    <evidence type="ECO:0000313" key="11">
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            <dbReference type="RefSeq" id="XP_022081051.1"/>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081052.1"/>
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    </evidence>
    <sequence length="1193" mass="133280" checksum="2D9F90B2F98D0A95" modified="2022-01-19" version="1">MLQVESPAGISHSLVKLVPMPGEIDNLNPPSATDTTVSTTTTAPKDEGHDISNGVSSSVNDLAIPNHRFSIESDLTYAPKLNTTSLRLAQSRQSRSGLLQRARATRLAAVQQHCQDEFTFKPQMSSASLKIAEALGTTFMIRQEQHLEKQRKKLEQRHQIPYKGRLSPVSTLKTKKSTATLKDKENAESSQTAWGTPTSTPNLNENRPAADIANSNNRLGVGGSISLHLTTPLSPVRAGRGLPQASVQLQRLQEGPYTQSGANLVLKRQKALPKPKSFGMHKRSATHPVDGASSEPLESTSPQATNHQRSKTVTSPEPGSSPRNKTKSLVSRTVAQSGERLRLAKLTAERAMKWKKIFMIQGPYPVVRECLRSRDWVEKQYRAMPPHKVKRKQGSDDNDTDDSDNDDDDDDNNDTPDAGATPDSDDEDSPLGDSDDIYGMMSRMVRNNDPFFIWTCRRDTINFRFLRKETIVNHFAKNGAFTTKSGLCTHLRNLKWYEDLDADTFYPRSYKICIEEEKKTFLHDYRLTAACSILKWVVQRHSGELDVPMDDNEDIPDEEAAKSDLEDSSTNSPRSQSKVGNKPAQSKAKRKTNPILSVSLIRTASDIVENYLRDVNHEFLDSDVDLNDVMTDKQWDDFIRQYCQLIFDGGLIAESSNHSAMCESLLNRVRAVLPQLDMDGLRNIWIIKPGAKSRGRGIICMNRLEEILKLVGNPAIVKEGKWVVQKYIERPLLIYNTKFDIRQWFLVTDWNPLTIWWYQSSYLRFCTQPFSLDNLESAIHLSNFSVQKNFENAATRSAMLPDENMWTSEEFQQYLRGRGCGNVWQDCIYPGMKRAVIAALQCTQDVVEMRKNSFELYGADFMLTEDFQPWLLEINSSPAMGATTEITEQLCHDVIEDTMKVVLDRRHDKNCDTGRFELAFRQPQVTVPPYVGAQLSIEGTSLRNPSLRIHRQRSQPNIISPRQPDGPVVLRKTNASGNPSQTSPRRPSQPGKAETSQTEPDAEADPELLRATNLEEMTRKLAASSALTQAKSSHDDITQRDSQHDSSSVGIVDGAWGRSCSRCNSGIPGVKLEADKTAADCACRRDSVKTPVGDDCISRPNSSRQSPVAGGWSPELIPRSGTFVSNRQGNLVTLSGPDPIQGVHKVGRAAFIAGKTRPNVNRQRRETKIQIRGGEVRVPCGTYPFSVSNAYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN78</accession>
    <name>A0A8B7XN78_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110974747</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082274.1">
        <property type="nucleotide sequence ID" value="XM_022226582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN78"/>
    <dbReference type="GeneID" id="110974747"/>
    <dbReference type="KEGG" id="aplc:110974747"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022082274.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="50161" checksum="5DFE12C604AC34CB" modified="2022-01-19" version="1">MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMTTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETFCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAMFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFDEEEEEGEIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNP1</accession>
    <name>A0A8B7XNP1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110974379</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081671.1">
        <property type="nucleotide sequence ID" value="XM_022225979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNP1"/>
    <dbReference type="GeneID" id="110974379"/>
    <dbReference type="KEGG" id="aplc:110974379"/>
    <dbReference type="OMA" id="YKAKPTN"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22709">
        <property type="entry name" value="FHA_KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000063">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000034">
        <property type="entry name" value="kinesin-like protein KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="367"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022081671.1"/>
        </source>
    </evidence>
    <sequence length="979" mass="109851" checksum="929E45C82B2E1048" modified="2022-01-19" version="1">MPEESVKVAVRVRPFNSREKARGAQLIIGMNAGTTTILNPEAPNEEPKKFNFDYSYWSHDGFEERDEVLVPVSPKYDSQKKVFDDLGVGVLQNAWDGYNSCLFAYGQTGSGKSFSIFGYGPNKGVIPIFCDQLFVEVANRRESGTKTEFEVMFSMLEIYNEQVRDLLNPASHKKGGLRVREHPKKGFYVEQLRNVPVQSYQQIEDRMDEGTRNRSVAATQMNATSSRAHTIVGITFTQKTVNDAGQEMSKVAVVNLVDLAGSERAESTGATGDRLKEGAAINQSLSSLGNVISALADRAKGKKVKVPFRDSVLTKLLKNALGGNSKTIMIAALSPADINYEETLSTLRYADRAKQIKTSAVVNEDPTEKLIRELKEENARLMEAIKKGGLVMVADDEDRKEGMTEEERAAIRKELEEEMQARLEATERELGYMKQSWEDKLKQAEGGDDGERAKKEAKKTTPHLYNLNQDSQLSGMIVFLLGPGSYKVGNNKAETLPEIVLNGLSIQKEHGVIANDNGKVFLEKGSSEAKILVNGDPLVGRVELDHNDRIMFGSNHLYVFQHPQLYKAKPTNYVGVVTYESAQEEIAEKNGFDMTSNNSKEDMLLHEDLVEMIPAVEEANAISEELDQKVKFEIVVMSPKARGLAHGRTEVCVKMRNLEKDLEYIWPRDKFVRRKYLMQEMYQNFTEGEDWSLPDEKNPFTEPADQEVLIGTVNVYMQSLAYLIESKEQLDITDYRGKELGLLNMELVPCHKNGKEIKEDDDLFIDHPNELVGRDLNFVVKINSAMGIPSKFTGIHCKYNVFLETEMIDTNHVNGTSSPEFKHKKVFNFPVVTSNLVQYLINDHLVIQVWGTQKDAQSKNKAKKNTKEIMLAEALTKGRDVNAMANQVSDPAMKAKYMFQFAVMKKRQERMETKIAQFRKLVTTAEMSNKARVETMVLKAVLNAQNDKVADKAIARVPKDEGAGNLGEETQKSGVCAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNT1</accession>
    <name>A0A8B7XNT1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110974474</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110974474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081832.1">
        <property type="nucleotide sequence ID" value="XM_022226140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNT1"/>
    <dbReference type="GeneID" id="110974474"/>
    <dbReference type="KEGG" id="aplc:110974474"/>
    <dbReference type="OMA" id="ELTCAYL"/>
    <dbReference type="OrthoDB" id="6413693at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034049923" evidence="3">
        <location>
            <begin position="32"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="34"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="149"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="247"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022081832.1"/>
        </source>
    </evidence>
    <sequence length="655" mass="72044" checksum="02E2E207C6296D22" modified="2022-01-19" version="1">MGTAQFNAMRRKCFRLVIFLMVKVLVRNVAGQEQHFVNEPRNTYILPGESATLYCRVANKTGILFWEKDSTILFKENGPEAGLSGPSTSWAVFGDASQGEYNLQLLGVSKSDQGSYVCMVTSSSGPKAANLTSSEALLTVLDLPTDGAPLCVLSIRDALTEDDVVDLTCAYHSNPSTETTLTWERLNTPADLSNSRQVLRDDGYLIKRHTVTLSAQDDADSYQCIASSPGKESSSCTTGFLSIRHRPIITISPLFLPAKAGDDVRFTCSLTTANPPTVTFQWYYSGAAVTTSSTGIDLIQTPGGDSQILVNNLVDQLGGIPVVCEATNEVGSTTVEAMISFEETQIATISREELILWLVPMSVMVAIVVLLIFLAIAVLDCRPFCHTFCNKSRRPLSPDRSMNSTWSAAENFGMSPSPMVRRLSDADSTDFYVTRAIRTSRPDDDTRDNNTSHESRARFDRNANHRPQRTPSPNYRNCSPDDGTSPRNTHIPSQNYYHSTPIGRPLIISDESRRSGTRHHYEQRRPRNERTRDHYRRSGQPSNSGSQPADSEIRSATRNSALSDSGLDFNASCSIDSRSPTPRDDLVVYAQIMQNRTGHIESGRNQSSASRTENTSLELPPGTPLPSSSTSHQRSTLDVPTEGMHRAHSVELPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNT8</accession>
    <name>A0A8B7XNT8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110974413</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081721.1">
        <property type="nucleotide sequence ID" value="XM_022226029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNT8"/>
    <dbReference type="GeneID" id="110974413"/>
    <dbReference type="KEGG" id="aplc:110974413"/>
    <dbReference type="CTD" id="51046"/>
    <dbReference type="OMA" id="PIHNKHY"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23970">
        <property type="entry name" value="GT29_ST8SIA3_oligo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF36">
        <property type="entry name" value="SIA-ALPHA-2,3-GAL-BETA-1,4-GLCNAC-R:ALPHA 2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="161"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022081721.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44543" checksum="160C967E76055364" modified="2022-01-19" version="1">MLLRRSTCRRCKKLLLLVMIGMTVCLGFVLHVSPESIHLDQLQQAYEEFSLTGGAWRGQDQSERSDNQDDEPENDSAKARLDAILSHKWSFNKEAAEEARKDMKQYFNPFDVITMTSDDVATGRLRRFYLSKKLNVNVVPPGLHRLLPKRLLFRNQHYRKCSLVGNSGVLRNSSCGRQIDSSNFVVRCNFATLKGYEKDVGTRTDVVTFNPSIIEKYHKLSTKADMARFESDLRKYHEKYVLWVPVFNRPYVTVALRTLLDFFDKHLGSSKNIQLAFPGNVLPDISDYWASKGIDEERISTGLLMYNMASALCDEIHMYGFYPFPDFKGRPIPYHYDHPLDRVGRKFDYGYRRFHALPDEFVYLKKLHRAGVVQLHLGECPNAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ71</accession>
    <name>A0A8B7XQ71_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane protein 135-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM135 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082155.1">
        <property type="nucleotide sequence ID" value="XM_022226463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ71"/>
    <dbReference type="GeneID" id="110974657"/>
    <dbReference type="KEGG" id="aplc:110974657"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031926">
        <property type="entry name" value="TMEM135_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15982">
        <property type="entry name" value="TMEM135_C_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein 135 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082155.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="53279" checksum="E29D5299A4FF8BFE" modified="2022-01-19" version="1">MVAPSKLWQVCSCYEMCHCWNPSCIGASWDIAKASWRYSFRTYLIFYTVSSLIFHKGIPSLRHLLVDVLRSSNFLACNAIVFISSICAFRQVLGRFFRWFVWGPACVASAVAISMEKKSRRAPLALYMVTLAIELLINIFLSRGWVKPIKYGEVILFSVSSAVALFLFRYGNMLKRDSLSALKLLVGVQEMPAELQPDEVRLQVTGNEKGSPREVSPTLQRQTFLSALRETLNSKCLQLVNWLKSLHKHRLCQHQSSCMYYVLQASIRKFAVGYAVQAALNLLRALPRVTTRPGLLVQALVRQDNFGLALFLSLFVGIFRSLSCLLRWLRNKDSPLHALIAGGAAGVSSIFYRSTTISLYFASKIIESLLIKGQQQGVIPVIPHAQSIVYALSTATVLHAGAYEPHNIRPAYWKFLLDLTGDNFGKMNRMLIAHLGTDSTRIYPDWPTYPDVSKLRLVDKDGMCVESLQPKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ79</accession>
    <name>A0A8B7XQ79_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Purple acid phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110975137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022082973.1">
        <property type="nucleotide sequence ID" value="XM_022227281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ79"/>
    <dbReference type="GeneID" id="110975137"/>
    <dbReference type="KEGG" id="aplc:110975137"/>
    <dbReference type="OMA" id="CKDVFEP"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867:SF3">
        <property type="entry name" value="ACID PHOSPHATASE TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45867">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034922614" description="Purple acid phosphatase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="4">
        <location>
            <begin position="144"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="5">
        <location>
            <begin position="352"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022082973.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="48418" checksum="F05642C99B4651CD" modified="2022-01-19" version="1">MTGIFGFQILVASVFLIVGIDGQLMSQPEQVHLSATGDVTEMIVTWSTFNDTPSVVQYGKVQPSNNAIGSSTKFVDGGSLHRAQFIHRVTLTGLEPGTKYVYRCGSDEGWSPLFFFPALRDGSNWSPHLALYGDMGNVNPQSLGRLQVGAQGGQYDAILHVGDFAYNFNYNEGKVGDEFMRQIESVAAYVPYMTAVGNHEVAYNFSHYKNRFTMPSYEANQNLWYSWNIGPVHFVVFSTEVYFFLEDSKQTKVNQLKWLEEDLKEASDPKNRTQHPWIITLGHRPMYCSDLDGDDCNKNGSLVRAALEDLFYKHGVDMEIWAHEHNYERLWPVYREKVYNGSTEAPYTNPKAPVHITTGSAGCQSRHDLFSHPRPWDAFRALDYGFTLMHVINGTHLTWQQISDDQHGKVIDEVLLIKDKHGPEAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR44</accession>
    <name>A0A8B7XR44_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110974972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974972</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082657.1">
        <property type="nucleotide sequence ID" value="XM_022226965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR44"/>
    <dbReference type="GeneID" id="110974972"/>
    <dbReference type="KEGG" id="aplc:110974972"/>
    <dbReference type="OMA" id="FYIRYKQ"/>
    <dbReference type="OrthoDB" id="191706at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="11"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="338"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082657.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="65610" checksum="0F75679ACA7C36A4" modified="2022-01-19" version="1">MFLPRLGSASYRWLPLAAGGCLLVGFVVPYIIAVRLGHVYPVLPYISDTGALHPENCVFGQMLNMAGVLLGVMIYIRYKQVAGNGPTELLELNKMSAFVGYLSAFFLSLVANVQINEESRQAVETEVHLCSAFTCFGSGYLYCWTQTWITYKLANNFWSWAMTLLRLALSLAGAFFMVTFLEFRELANAEFNGTYADTMHWNPYDGGYMYHVYSAASEYSLGIVLLIFTLSLYKEFSSIQSPDRKVDLTEERPHVEGHVVSAGDPLVSLICFSRINSVVERFVVNTHTISFAGAVRLLGQGLGSSHPIKGYSFLQMLTSRSLTGSRSNADRMLSGHGFGWVPLGAGALLLVGIVVPYIIAVRLHHVYPFLPYISDTGALQPESCVFGQMLNAASVLIGALIYLRYWQVANRRKDVPADVLRWNSASRTPGYLAVFGLSVVANFQVGLEPNLQVQTSIHVVGSVLCFGLGVIYGYLQSRISYALSTDFWSWAMAVLRFFLTALCAIFFITFSVYITLAFQQFNGTFADHMHWGPDDGGYVDHIISAVAEYLMALTFTLFLITYYDELKTIKRVRELWCPRRLIPSAAPTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRA8</accession>
    <name>A0A8B7XRA8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 18-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083378.1">
        <property type="nucleotide sequence ID" value="XM_022227686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRA8"/>
    <dbReference type="GeneID" id="110975306"/>
    <dbReference type="KEGG" id="aplc:110975306"/>
    <dbReference type="OMA" id="TFSKQQY"/>
    <dbReference type="OrthoDB" id="411535at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026721">
        <property type="entry name" value="TMEM18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14770">
        <property type="entry name" value="TMEM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022083378.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="16579" checksum="59BB684AE30458B9" modified="2022-01-19" version="1">MAPEQAIGVNDIDGMLAYLEHIDWTESWLITLLLFHATCAVFTVLTRKYFNVQLVYFFLLLILIYFSETINEHAALNYKKFSKHQYFDSNGLFIAVVFSLPLLCNCLLIVMIWVYQTAHLLVKVKRAEVRQRAQEEERKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRM6</accession>
    <name>A0A8B7XRM6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975054</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022082847.1">
        <property type="nucleotide sequence ID" value="XM_022227155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRM6"/>
    <dbReference type="GeneID" id="110975054"/>
    <dbReference type="KEGG" id="aplc:110975054"/>
    <dbReference type="OMA" id="VENADFM"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016206">
        <property type="term" value="F:catechol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082847.1"/>
        </source>
    </evidence>
    <sequence length="171" mass="19277" checksum="E89EF1CECAB592F9" modified="2022-01-19" version="1">MEQVVRKAAPKVCFELGCYVGVSAMAVARHIPPGGRLITAEIDAKYAEVAREMVRFAGLDKVITVVNGRADDVIKVLRSEYSVDKLDLVVLDHSKWLYKTDIKELEKERLLRKGTVIIADDCLWPCAPDYLNYVENDPRYQTERFYSIALPGLFDAPDAIAISTYKGDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XS91</accession>
    <name>A0A8B7XS91_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="9">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110975040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022082826.1">
        <property type="nucleotide sequence ID" value="XM_022227134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XS91"/>
    <dbReference type="GeneID" id="110975040"/>
    <dbReference type="KEGG" id="aplc:110975040"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05236">
        <property type="entry name" value="FAR-N_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000143">
        <property type="entry name" value="Fatty acyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="11">
        <location>
            <begin position="48"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acyl-CoA reductase C-terminal" evidence="10">
        <location>
            <begin position="390"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022082826.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="62440" checksum="9713BE3840010A86" modified="2022-01-19" version="1">MPAFAEGETAVDIQEKPLEEETDLWTMATNNNALVSIPEYFTDKSIFITGATGFIGKVLVEKLLRSCPTLKQIFLLVRPKAGQTARERLSVITKSKLFDKIREESPELLDKLVTIEGDIMEPNLGISEEDVARLQEEVHIVYHSAATVRFDEKLGLSLKLNVGSVQKMIKLCQDMKNLEVFLHVSTAYANCDRKQIEEVVYPPPMDPYKLMNATEWMSEDMLATITPKILGNRPNTYTFTKALGEYVLLQEGGGLPICIVRPSIVGAAWKEPMPGWIDNFNGPSGLFIATGMGLLRSMLADSEAVADISPVDYVVNTLIAASWHTGLHRPATTPIYNCVTSSTNPSKWQVIGNITHYFTKTPLEMVFRRPNAAFTSNPIMHTYWNMIGSMVPAFFMDLALQVRGQKPRMVKMCDRIYKSTKTLKYFTTHHWEWSNHNLEAMQALMSEDDKKSFYIDVRPLDWEAYIETYCIGTKRYVLNEDLNSLHIARRNIRTLRNIRWMFNTVLLVLLWRVLIARSQIARNLWYFVTNLFFKFLRYCRATSSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTH4</accession>
    <name>A0A8B7XTH4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterogeneous nuclear ribonucleoprotein A3 homolog 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110975276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022083310.1">
        <property type="nucleotide sequence ID" value="XM_022227618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTH4"/>
    <dbReference type="GeneID" id="110975276"/>
    <dbReference type="KEGG" id="aplc:110975276"/>
    <dbReference type="OMA" id="FHHINGH"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN SQUID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="106"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083310.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27643" checksum="5AB4FAE87865FB76" modified="2022-01-19" version="1">MASQVTNTSEEPENLRKIFLGGLNRSTTKDDLKTHFEQFGEVTDSIVILNTEKQSKGFGFVTMATIEETDKSLRENNCGSHDICKKKVEVKRAIPRDSNISAEATNQIFVGNLGTNITEEHLREYFSQFSPVKSTKVIKEKGGDKSRGFGFVEFEEPFGHHAVDKLAIMEKHTIEGRQVYCNKAEDRSNKEDNYYGRHQAMRGNPFGRNPGRSGMPGYYDGYGGGNYGCYGGARGGYGGGGYGGDPYGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUH6</accession>
    <name>A0A8B7XUH6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arfaptin-2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110975929</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084499.1">
        <property type="nucleotide sequence ID" value="XM_022228807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUH6"/>
    <dbReference type="GeneID" id="110975929"/>
    <dbReference type="KEGG" id="aplc:110975929"/>
    <dbReference type="OrthoDB" id="9994780at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07660">
        <property type="entry name" value="BAR_Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000003">
        <property type="entry name" value="arfaptin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010504">
        <property type="entry name" value="AH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030798">
        <property type="entry name" value="Arfaptin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141:SF5">
        <property type="entry name" value="ARFAPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12141">
        <property type="entry name" value="ARFAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06456">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01015">
        <property type="entry name" value="Arfaptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50870">
        <property type="entry name" value="AH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AH" evidence="8">
        <location>
            <begin position="216"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="323"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022084499.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="47356" checksum="0A073146870411E2" modified="2022-01-19" version="1">MTTENGTYQPEDDLDDTFEQDLRDMLRDGPSLSDAAATIQSGTSAHRSSSGGSGGGSNSGGNSNNGSGGQFTGVDLSSPQKSPMSSPPQPRLIQNPTVGSRLAQPSRGAEENQNDQPPSTEKPTVRTAAPAAAVQPAVQPVATMPTAQTTPVGKPMTGIGNTTFTSTPPAPGQTTDQVSTSVMAKAKLDSLKSWSISTYKCTRQLVQEKLGKASRTVDLQLEAQIEVLRDTQRKYGNIMKLARVLTNHFYQVVQTQRSLGDAFAELAQKSTELAEEFNYNAETQKSLCTNGETLLGALTFFTSSVSTLCNKTMEDTLLTVKQYESARVEYDAYRADLESLQLAPKDASTQARLHDARVKYEGQKERFDKLRQDVAVKLKFLEENKVKVMHKQLLLFHNAISAYFSGNQQALEATLKQFSIRPKSANELKPSFLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVI6</accession>
    <name>A0A8B7XVI6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110975603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083886.1">
        <property type="nucleotide sequence ID" value="XM_022228194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVI6"/>
    <dbReference type="GeneID" id="110975603"/>
    <dbReference type="KEGG" id="aplc:110975603"/>
    <dbReference type="CTD" id="51659"/>
    <dbReference type="OMA" id="DSLNCMY"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21694">
        <property type="entry name" value="GINS_B_Psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.50:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="6">
        <location>
            <begin position="65"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022083886.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21281" checksum="15CDCD085C4A1EF2" modified="2022-01-19" version="1">MDPSEVEFLAEKQIVTIVPNFSHDEVFLIGGNIGPFNAGLPVQVPMWMAINLKQRQKCRIQPPDWMDVDKLQAKKQEEKDSPIFQPMLNENYMEVTKLLLSHATDDIPHADEVHTLIKDIWDLRMSKLRQSIDKFVKDQETYARLDNLSLMEINTVRPFLTQALDHMHTLRMNMLTGGPPNTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVR7</accession>
    <name>A0A8B7XVR7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 2U1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110975828</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084337.1">
        <property type="nucleotide sequence ID" value="XM_022228645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVR7"/>
    <dbReference type="GeneID" id="110975828"/>
    <dbReference type="KEGG" id="aplc:110975828"/>
    <dbReference type="OMA" id="EMFGASN"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF397">
        <property type="entry name" value="CYTOCHROME P450 2U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022084337.1"/>
        </source>
    </evidence>
    <sequence length="498" mass="57029" checksum="8F867FC78E8E3DA3" modified="2022-01-19" version="1">MVFNVIGDAASSLNVQTVLLFVGILLLTLSLTWMRHPRNLPPGPPAWPLIGNTRGLKKGPIHLVLADWARQYGSIMSIWIGSCLVIVLNDIGAVKEALVKQADCFSDRIKTDDPQHKGSIIMSNGNVWRERRRFGLSALRTLGMGKRSVEHKINEEARYLLESFDARRDKPFDPEHDILNAVSNIICMITFGYRFEYSDPKFAQLIKLIKTNLSSSSFLSVSFLHYLFNRSEHVERLKRFEKTAAFIQGIVEEHRHSFDPNDIRDIIDMYILEIRQHEQMEKVIEGEVAFHEKTMWRGIRDFFVAGTDTTTNTLMWLILYMAIYEDVQKKVQKEIDAVVGCDRQPVGEDSNEMPYTNAVLMEMQRHKPVTPNAVPHQTSYQTEIFGYTVPANTIVFVNLWAILRDPKHWNDPEKFDPTRFLSGDGKTVKKPEAFIPFSFGRRICIGETLAKMEMFLFFVNLLQRFTFSLPAGKPPPSLEGIVGITLGPHPYEIVAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYE6</accession>
    <name>A0A8B7XYE6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Leucine-rich repeat flightless-interacting protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110976719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LRRFIP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085923.1">
        <property type="nucleotide sequence ID" value="XM_022230231.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085933.1">
        <property type="nucleotide sequence ID" value="XM_022230241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYE6"/>
    <dbReference type="GeneID" id="110976719"/>
    <dbReference type="KEGG" id="aplc:110976719"/>
    <dbReference type="CTD" id="9209"/>
    <dbReference type="OMA" id="GNVIRME"/>
    <dbReference type="OrthoDB" id="10028421at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019139">
        <property type="entry name" value="LRRFIP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212:SF0">
        <property type="entry name" value="LD07988P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19212">
        <property type="entry name" value="LEUCINE RICH REPEAT IN FLII INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09738">
        <property type="entry name" value="LRRFIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="155"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="298"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022085923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085933.1"/>
        </source>
    </evidence>
    <sequence length="447" mass="51037" checksum="CF1AEE3AD339109E" modified="2022-01-19" version="1">MCAATTNGGSSPGQLSPGVSPLGSGRKRTTNRAYKAEDQALSDITQEAEARLAKKRQARAEARSIRMRELEKMQKEAEEQMDKEYEQQKEEKKSHRLRFMKSSSVIPPVVPNSSGGSSSRRGSTDSIEFESVALKSEAAAPPAEEEPSPKELEAIADLEEKYKKAMMNNAQLDNEKATLIFEVDMLKDRQEELEEAMLEVQREARDKHRELESKKRENLLLQKEVDSLKEMVTQRDTLIAEHGLLLVGDEERLSDKDLPEGQASHKPKLPKVGTIVVVSPEAAELLEVVGDGPLDVRLKRFVEERKELLEKIRRLEIDLEDEKDKVATAERRRPAQTSSVNGPEIDVLDIQREASRQVNEYRFKYQKAEQELATLEGHVMRLEGQVKRYKTAADTAERVEEELKQERRKLQREIRTLKDKNEEFETENSHLTKRLEKMKNAKLSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYV3</accession>
    <name>A0A8B7XYV3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coiled-coil domain-containing protein 151-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110976339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085215.1">
        <property type="nucleotide sequence ID" value="XM_022229523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYV3"/>
    <dbReference type="GeneID" id="110976339"/>
    <dbReference type="KEGG" id="aplc:110976339"/>
    <dbReference type="OMA" id="MEREMYQ"/>
    <dbReference type="OrthoDB" id="10255247at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035253">
        <property type="term" value="C:ciliary rootlet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097542">
        <property type="term" value="C:ciliary tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049258">
        <property type="entry name" value="ODAD1_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033192">
        <property type="entry name" value="ODAD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46518:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21773">
        <property type="entry name" value="ODAD1_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ODAD1 central coiled coil region" evidence="4">
        <location>
            <begin position="155"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="340"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022085215.1"/>
        </source>
    </evidence>
    <sequence length="541" mass="63807" checksum="D1AE0A3156D67888" modified="2022-01-19" version="1">MTSSNQDSTMNAWTVYDHMDECRGKIALKERDHRAYYESSQVDKQCNEDEIAALRRNNKEKRVVLAQQTRHGDERVIHEALMSRRDENLALRRKTAEDAIAEMDQKMCEKEKQLNSLREEKEKRQSRIKELETALARLELLAKNSDNNYAQYDLKTIRMVENNLDKARIKHETARKLQQTYLEIVRCLEEERLSLPKRLKALEGALEEQRQELRELTGISQDARIKRDQAKAELSVLEQTMIEAKRSRDRTLTRMKKQADKQKEMADKIEKRARATLQADDPSQESKRQSQMDEDNWVKVTTYEEAFRRIQEATGVSNIEEIEARFMNQGGTYEHLLAQKQTVEKQRKWLTEQKRQLTQQYEAMKYSGESKMSQGQQLLERMQEHLNKTEQRRDLLRNSVHKNNMVLTDVKNGIHHVYETLKDIKLKPPMRNNANLGDYLDQLQICENKLQKLMTQANVRDSASFKKVMNSTEFQEFMENTQKAENLRVRLDEPDSNDSDDFGYDSQDNEDMMTNADIKHQGQVLMDQKKTKKRARARRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZ37</accession>
    <name>A0A8B7XZ37_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dopamine beta-hydroxylase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110976390</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copper type II ascorbate-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085295.1">
        <property type="nucleotide sequence ID" value="XM_022229603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZ37"/>
    <dbReference type="GeneID" id="110976390"/>
    <dbReference type="KEGG" id="aplc:110976390"/>
    <dbReference type="OrthoDB" id="129121at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042421">
        <property type="term" value="P:norepinephrine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006589">
        <property type="term" value="P:octopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.310:FF:000004">
        <property type="entry name" value="DBH-like monooxygenase protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.230:FF:000001">
        <property type="entry name" value="Monooxygenase, DBH-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.310">
        <property type="entry name" value="Copper type II, ascorbate-dependent monooxygenase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014784">
        <property type="entry name" value="Cu2_ascorb_mOase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020611">
        <property type="entry name" value="Cu2_ascorb_mOase_CS-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000323">
        <property type="entry name" value="Cu2_ascorb_mOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036939">
        <property type="entry name" value="Cu2_ascorb_mOase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024548">
        <property type="entry name" value="Cu2_monoox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008977">
        <property type="entry name" value="PHM/PNGase_F_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028460">
        <property type="entry name" value="Tbh/DBH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="DOPAMINE BETA HYDROXYLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157:SF29">
        <property type="entry name" value="DOPAMINE BETA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03712">
        <property type="entry name" value="Cu2_monoox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01082">
        <property type="entry name" value="Cu2_monooxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00767">
        <property type="entry name" value="DBMONOXGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49742">
        <property type="entry name" value="PHM/PNGase F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00084">
        <property type="entry name" value="CU2_MONOOXYGENASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034578503" evidence="14">
        <location>
            <begin position="23"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="15">
        <location>
            <begin position="43"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="582"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022085295.1"/>
        </source>
    </evidence>
    <sequence length="622" mass="69326" checksum="5224997A3866B445" modified="2022-01-19" version="1">MLAASLFLLYAVTGGFYYPVCSEPHSAFPYSILLVAEGQDSDQAATLFWAVDFEKETVDFRLSVPLIYGGTLRENGEWFAFGMSPDGTLSNADLVVFEFPQGELKLTEAYTDDTGEVHEDGNDHDYVLLGWRVSPGVGGNDESPAHLEVEFRRKFDTCDRHDYLIDSGTVNLFYLRGSHSSISSGYIDPREAEIAFQRAQLLKSTRRTPPLPPNVKTADIVMHNTAIPNQATTYWCRVQKFPDIEEDHHIIQYEAVVTPGNEGIVHHMEVFHCILPAGVKVPDYNGECEGEDLPAELASCRRVIGAWAMGAKAFFYPEEVGVPIGGSSVSSYVVLQVHYNNPRLREGVLDSSGIRFHYTSSLRPYDAGILEIGATYSPNLSIPPESNAFYVTGYCSPDCTDKGIPDRGIRVFASQLHTHLSGTAIWTKHIRNGVEMKELNRDDHYNAMFQEIRFLQKDVTVLPGDALITTCRYDTSARQNVTLGGFGIQDEMCVNYMHYYPSINLEVCKSTIASTALAAFFKTVDSRTGDSPHDVNLTSPSAVANCFLHMTWTPSVKLLWQYVINEAPLDIECLKSSGQPFTGKWKDQPPPSVKIPLPRKKRKCPHKKIHPFQRKLGSSPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y022</accession>
    <name>A0A8B7Y022_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ETFB lysine methyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein N-lysine methyltransferase METTL20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. ETFBKMT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085640.1">
        <property type="nucleotide sequence ID" value="XM_022229948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y022"/>
    <dbReference type="GeneID" id="110976570"/>
    <dbReference type="KEGG" id="aplc:110976570"/>
    <dbReference type="OMA" id="WAYPWAG"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050078">
        <property type="entry name" value="Ribosomal_L11_MeTrfase_PrmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43648">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43648:SF1">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT LYSINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085640.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34310" checksum="4006E3827010A5BD" modified="2022-01-19" version="1">MFIRVIGSSLFKCLHEFSRARQGAHLQFPCRARSCHGNSNFLHPVMLGSDPRMSGHKHRRRKSCYHSNPTSLTRLQCTQNGAIRGEEISTIKQFILDNTVVTRNHLTPEVALRLMTSSCRLWSAPSEQSSSILAHCGIDEPFWAFYWPGGQALTRYLLDNPGVVSGKSVLDVGSGCGASAIAAALVGAKSVLANDIDKVAIQAVKLNAEMNSVAMTTTSRNLIGRLADHWDVVLLGDMFYDKDFTDTVTDWLRCLADRGTEVLIGDPGRIFLRDHPVRDCLVNIFTVDLSESCRLENNGMTQGFVWKLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y353</accession>
    <name>A0A8B7Y353_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-4C adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110977168</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086745.1">
        <property type="nucleotide sequence ID" value="XM_022231053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y353"/>
    <dbReference type="GeneID" id="110977168"/>
    <dbReference type="KEGG" id="aplc:110977168"/>
    <dbReference type="OMA" id="YLICTIG"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF411">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="39"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022086745.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36233" checksum="D29CB410E9BF1892" modified="2022-01-19" version="1">MCISGPNTTNFTVEASDDIFMDILSVCIWTLTTLLILFLNSMCLILLHKVKGFSEATIVFLKSMTIGDLILGLCFYLPTVGVFLNDRRWPYGNICCYIQAWVIRTVLPLSGASVLLVTIDRYIAIVYPMQYETWLSLRRARIITCSVWTIANFYGLLTSILANWMQCFSQHYLICTIGEFNHSKAVITLIVIGVGTFLVITVMYIRILLIAQKHASQIAKHRPSVTSMASATDVPSPSPNRKSFTTVFIITMTLLIGWLPSVILGLINVETPSIPLVIATQIPLASVSWLNVIVYYTRNQAFQEAAQELHLQLIQYCKGCCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6M6</accession>
    <name>A0A8B7Y6M6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fibronectin type-III domain-containing protein 3A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110977831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087990.1">
        <property type="nucleotide sequence ID" value="XM_022232298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6M6"/>
    <dbReference type="GeneID" id="110977831"/>
    <dbReference type="KEGG" id="aplc:110977831"/>
    <dbReference type="OMA" id="GETEAMC"/>
    <dbReference type="OrthoDB" id="443915at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000373">
        <property type="entry name" value="fibronectin type-III domain-containing protein 3A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF11">
        <property type="entry name" value="FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="43"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="152"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="248"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="338"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="438"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="537"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="631"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="719"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="817"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022087990.1"/>
        </source>
    </evidence>
    <sequence length="973" mass="107158" checksum="6F2508F127782C25" modified="2022-01-19" version="1">MENGANSRQGNGRKKRHSGGGSQRIDENEEDPHVKKLRDILSNIQPPDVYNRMPRSVSVRWSLPQVHSGNVDCCSEDDVDLSSTRFELVLSERNRSGSSKTFYCHGTENKYQIPDLKPATEYQLSVCAILDNVKGALSQPAVFETQGCPPDVPLIPRLTGRTKNSLGLRWTPPLANGSKIHSYLLQCDKGSGSGSFVDVYEGPDRMFKVTKLQPSTLYRFRLQAINDFGASDFSPEVSYYSSGSAPNQPEPPTLREASAHSLHLEWEKSAGEINGYILEMDDETKRYGFQVVYRGEETNHQCKNLARNSEFKFRLCAFNEEGNSRSSGVVAFQTLPDVPRAPCKLSLKGKVHSTGFKVSWDPPKDAGGSDVTSYCLQMNNGTNEPFRSVYEGLERECNLDNLEPGHTYRLRVQCSSRGGESAFSDVCSVTTFPVCPGQCLPPRLHGKPRATSVNLRWSPPEYHGGTSLQEYTMEMTTAADDTPKEVYRGGTSIMECTVGTLLPGRPYAFRLRAFNRIGPGPLSDPLHVTTAAGPPDSPTELVVSSRGTSVAYVSWEKPCCNGAEVHEYRLERASQNGSFSTVYNGFAPYCELKFLQPATFYYLRVQAINSAGPGPFSDVATYESPPSSPEAVASLRLLSSTSESLLIRWTEPNCCGAEILSYNIDIGEKPVISVPGHAKEHCLEMLQPNTKYRIRIQAVNSIGVGPYSASLKVTTKALPPDPPRLECALYSHQSLKLKWGDSVKSPVDVRIQNYTLEMEDRKGRYCMVYSGANVSHKVSKLSEQTSYRFRIFASNDAGDGPYSESYTFTTTKAPPPCLKTPKVSHVTEDCCVVVWQALGNIQNDVVIYQCQCQRVRDSEIKLVYRGSGSSIIVPDLSPGTEYRVRACAVRLPEDGGPELVGAYSPWESFQTASPLATTVASAASSVAASEDAQRDEDAPAEPKGLEDQKIVAIFLAGFFFVAVIFAWIVAFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y768</accession>
    <name>A0A8B7Y768_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FAM221A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM221 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089058.1">
        <property type="nucleotide sequence ID" value="XM_022233366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y768"/>
    <dbReference type="GeneID" id="110978396"/>
    <dbReference type="KEGG" id="aplc:110978396"/>
    <dbReference type="CTD" id="340277"/>
    <dbReference type="OrthoDB" id="310364at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026755">
        <property type="entry name" value="Fam221a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214:SF2">
        <property type="entry name" value="PROTEIN FAM221A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214">
        <property type="entry name" value="PROTEIN FAM221A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14753">
        <property type="entry name" value="FAM221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022089058.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="37531" checksum="B50C20812BC81F1A" modified="2022-01-19" version="1">MAAQGYHLKLGPGAAESIDQYLEYRRIVGEDDGGELFTPEQYEAYKRDVVPTRMKNRLFVSWTSPNGWDCKLVGPETPCFCQHRYKQHKTDFKEIPTERPLLLPCRVKGCRCQSYNYVPLNGSRPLRCRCKHFTDEHSEDPSHACMKSSCNCVSFKSSFTCSCEQPTYLHEMIIETKEERLARGHPVGHDTPYAAMGGLTGFSSLAEAYMRLDDSGIGPADEEFLNQPITSSDHPFLRMHASTFQQLEPPDKKVDALTKKMANFKMTGTDADMEYYEMRYQQRLKEERMKKRGVQPGPRRPQEGAAVSGHRVQPGSAKSGTRGPSRSATKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9F5</accession>
    <name>A0A8B7Y9F5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089187.1">
        <property type="nucleotide sequence ID" value="XM_022233495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9F5"/>
    <dbReference type="GeneID" id="110978470"/>
    <dbReference type="KEGG" id="aplc:110978470"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089187.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27299" checksum="B5F698B026196933" modified="2022-01-19" version="1">MFVLGRFSGKIINRWPASLLGKKGVLSSNTQWQQCDMFATFSPSLLPARDGGLPGSCPQITRKHHWDYGLCGDNEAQVRDQLWSTAAEIVDSAVFSSSSARSLYGWTRSMILAGENNSSNSNINISIGTSNNVNGSNNSNSSNIDSSTNISNNCSNINSSNNRNSSISTSNNSRNNSNISSSTSTSNNSRNNSNINSSTSNNCSNINSRNNSKKRQHQQQHKHQQQHSHYQQQQYSQLQQQRPQHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9Z3</accession>
    <name>A0A8B7Y9Z3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110978974</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090064.1">
        <property type="nucleotide sequence ID" value="XM_022234372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9Z3"/>
    <dbReference type="GeneID" id="110978974"/>
    <dbReference type="KEGG" id="aplc:110978974"/>
    <dbReference type="OMA" id="WIAGFNI"/>
    <dbReference type="OrthoDB" id="200726at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35169">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35169:SF3">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT FE(2+) 2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034478728" evidence="2">
        <location>
            <begin position="26"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="191"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="414"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090064.1"/>
        </source>
    </evidence>
    <sequence length="679" mass="79419" checksum="D4B01D31170DB807" modified="2022-01-19" version="1">MKVWGVTCKVWIITLWALLLSLVKNFDQNFGSKADSPSVVTFHEASSRFWPAPDPNRFGIASNLNRGAGESQGKLSKTQPSSFKTKDGRPAAVFDDVLEYKTQMVLHDYLHLAGDWRFHNYNGPDENRNGRSSSGIPWMASFDTDTFGKSQTGRHILSLVRSLAQPRKGMDDDGDYEPYKVVCNILRRGDIIFPHRDAHRNETEFTVLLYLNQLWRKNDYGELLLLDEGDVFATVGPKFNRVVVWDSSIDYLTRPPGMAFKQSQFFLMVHYTRNHTKALHYKGARLQSIAERKQATAELFSSMNQPVSETMDVGSHVTMKYQAKNGKKIFVFDDLFSTEDLDKLRSFTVRHGHYFFDDSIDTDSDNVQWIAAFNIDDYVRSRMWNITRRVARYVSGTDKWFPYDIACNVIRSYDHTRIHEDCEKQEDEWTFLLYLTPNWTANYYGETVFRENNRDDSEYVASVVPQYGRVVIFQGIIPHSARPPSTLFKGARLSFAVKLSATPWLARVKMLKQEFAHEESMHQSVLSIMKYYNDASFEARYKKQLIGTAQEIMELEQEQRQRYLKDLRQMHLSRRDDEDMQRDEDGDEDDDDEDDDNDREEGEEFEYEGEEDGVFDFEESYHREDENEFPEINLRKEYIYNLIKTLNHDAEALTIHYAQFLKDREVMTKRYSEEIAKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAT0</accession>
    <name>A0A8B7YAT0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphotriesterase-related protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110979116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090354.1">
        <property type="nucleotide sequence ID" value="XM_022234662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAT0"/>
    <dbReference type="GeneID" id="110979116"/>
    <dbReference type="KEGG" id="aplc:110979116"/>
    <dbReference type="OMA" id="VAVHEHI"/>
    <dbReference type="OrthoDB" id="9998343at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819:SF3">
        <property type="entry name" value="PHOSPHOTRIESTERASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022090354.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="30605" checksum="4E0EF7D4CDD57C57" modified="2022-01-19" version="1">MNEDSALIDELLYLKENGCQSLVEQTIYGLGRNVGKLVDFSVASGVHIIAGTGYYYSSTHPPEVDGMTQEEIERLLTSEILVGADGSMGRCGLIGEIGCTWPMTANERKILRATAAVQSTLGCPVSIHPGLDPKSPEEAVRILQEAGAQVDKIVMDHLDTCFFTREGLLEFSELGTLLEFDFFGTEVAHCQYHPEIDSMNDGQRIQMIKSLVEEGMEDRVVISHDFHGRHQMMKYGGHGLSHISLHVLPKMRARGLSQAVIDKITKTNPQRWLTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YB64</accession>
    <name>A0A8B7YB64_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Alpha-2C adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110979192</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090479.1">
        <property type="nucleotide sequence ID" value="XM_022234787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YB64"/>
    <dbReference type="GeneID" id="110979192"/>
    <dbReference type="KEGG" id="aplc:110979192"/>
    <dbReference type="OMA" id="ANMTFFI"/>
    <dbReference type="OrthoDB" id="6376512at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="64"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="321"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022090479.1"/>
        </source>
    </evidence>
    <sequence length="589" mass="65271" checksum="FE764B4F7501B4C5" modified="2022-01-19" version="1">MTNTTDSNFYPSATATLQDNSTRLATSPWAETVTDSPTHSDISTAEKVIEALLLSVICLVAFSGNVLLWCVIVRNKALRTTSNALVLCLSSADVLVSVCNMPITIFTIVKGNQFFSNELCVVLGFANMTFFIASVMSLAAISLNRYVLIVHPKRFKAIYTIRNTGFVILAVWLLSLALASPPLIGWARYDYLPGQSFCFCYWEDSISYTFFMVIVCFGGPCSVMSFCYYNILREVRRSRKRLSTGPGSADVSSMNSVQSALSTVSNNNSSVRENGQPRGDEAPLQNSALNKGFVEGDSDNQGPIQKSRLTSLHQALTRQLSRKRFRVEPSSPETQLPASVPGGNRPRSLPTRMTSIKIKDDQNNRNQNTSLERTGSKYQQQNQPSSSSKLPKIRLQAFSRSVSLDSRRGSGSSLVRELQQDGVSKSGKISPKIQAKIARQLSGSTLAVPGLKAAVVMRRKRAKTASEMRRKQEELRLTKSFLVVILAFIVCWFPFCITMFWSVFSPYPVFRPVDMASLLLGFFNSCCNPVIYGLMNNRFRAGFKHILCCHWTPWYRRRNAGKKVLDRGFGSITGTAAGGGYQDDISCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCG6</accession>
    <name>A0A8B7YCG6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 15 member 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110978976</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090070.1">
        <property type="nucleotide sequence ID" value="XM_022234378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCG6"/>
    <dbReference type="GeneID" id="110978976"/>
    <dbReference type="KEGG" id="aplc:110978976"/>
    <dbReference type="OMA" id="YVLYAQM"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090070.1"/>
        </source>
    </evidence>
    <sequence length="590" mass="64955" checksum="7E0F8C3A8116DA64" modified="2022-01-19" version="1">MANKSPEGINKPMKVSAKDGSAEKSETAFVDLPAPTESFGFQRDRLGVVLCILVCELCERLTYYSIAGNLVLYCTNSLKFSSADATTISLIFTGTSYFLPVLGGWIADTVSGKFNAILGAALIYCIGTTLLPLISIDYTKYGPHLGLSTGQQRGFFLFGIAIIAVGTGGIKSNVGPFGAQQLDDKGEGAVKTFFNWFYWFINVGSAVAFSAVVYVQQEIGFDVGFAIPACALVVAIIMLLIGRKWYRMRPPEGSVFTTVAKIIWEAIIRGRKPGARKDKRTSWLDSAKQSFGGHFPDVKVNEVKSLGRILPVFAVIIFYWTVYNQMSTTYLLQGERMRIVYNNFTIPVAAINLFDIVIILVLIPFVDRVFYPFMAKLGYPLSSLRRIGIGMVLAVLSMVIAAGIEFARKANIEEYGYFKQELANKAFNASELSIFAQIPQYTLIGASEVFTSITGLEFAYSQSPKAMQGVVMGLFLLTSGLGSYIGSLLVVVVNAITSEDEWIPDEINYGHLEYFFFLLAVIMTINFVCFLLIARGYVYVKDAELILLPETDDESSRRSSLAGGNRRNNQKDTTPLLMNDDVAPTSFTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDD7</accession>
    <name>A0A8B7YDD7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022091269.1">
        <property type="nucleotide sequence ID" value="XM_022235577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDD7"/>
    <dbReference type="GeneID" id="110979608"/>
    <dbReference type="KEGG" id="aplc:110979608"/>
    <dbReference type="OMA" id="AMHITNL"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000001">
        <property type="entry name" value="DNA polymerase gamma, catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.390:FF:000002">
        <property type="entry name" value="DNA polymerase gamma, catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="8">
        <location>
            <begin position="883"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022091269.1"/>
        </source>
    </evidence>
    <sequence length="1237" mass="141799" checksum="330AC342BBF38030" modified="2022-01-19" version="1">MYIVHVAYIYMYDHNVSIITRGCHIVQIPCWKSPCGKKYIFEVRMTHLLRIPLCSHCFSIKCQRWIIQQHVHVLANPFPLISCRSCSDSSYKPRLNPINIQMLSQHLHEQIFKSDKRRRQMEPSSEDIQKSIQHLKDHGLWGKHVDFLPEVDFKLPKLYGRNIDEHFRVLANKQSDKYIKISEALSFGSLPTMPQEWAFMKGWTMYDGSGNQTAVDYPLEEAVVFDVECLMAEGNFPTLAVAASTEAWYSWCSERLVEEHLSLSPRITPADLIPMETTNSFRLSESVRWKERLVVGHNVSFDRSFIKEQYFLKGTKTRFLDTLSLHMAVSGLTTYQRALWLADRTGKGAKTQYLAKKASKKPAGPPSTKWLDASSPNNLADVYALYSRDNERLDKSKRDTFVTGTMEDVRSDFQELMSYCAKDVEATHVVFTHLFPKFCERFPHPVTFAATLEMGQAYLPVNQNWERYLRESQETYDDLQQEMKMALMHLANDACQLMQNDGYVEDPWLWELDWSTEDYRLKKEVIHKKRRATWTSKSVEEEATTVCEMSKDDADKDVMPVMKTSQGVEMVVGDGLTEEERLENEARQERLREVMETAKRIPKIKQHMVGYPMWYRELCPRKVDNDWAPGPCLISSQVRIAPKLLRLTWEGYPLHYDSRHGWGYLVPERKEEERKEELENDDGGSKQNRETVQFPVNSLKSFIQDKIPDNSAPSLNIKTSPIDLDSQASVIQSNVEDYWTYSEDESMSDDNDRIPSLKPPGNPKDTSDDHSQQPYHDVKIPGCWFYRLPHKDGGSNKVGNPLAKDFLNKLEDGTLASAGGAQATRILEINKLISFWRNASKRINSQMVVGLEKNHLPRAVTRNHDYDEDSFYGAIIPRVITAGTVTRRAVEPTWLTASCTALGWMTLQGKKSDGTDMHSMTASTIGISREHAKIINYGRIYGAGRPFAVRLLMQFNHRLSPEEAREKANKMYAATKGIKMYHIEEKSAEFLLKHGLIDKRDDHYLSVAKFRQISKHIKPDKRNLLTDGKKWTKGSESAMFNQLESIAQSEHPKTPVLRSSISTALEPKRVNSEFMTSRVNWVVQSSAVDYLHLMLVCMRWLFEQYNIDGRFCISIHDEVRYLVTSEDRYRAALALQITNLLTRCMFAYKVGMNDLPQSVAFFSAVDVDTVLRKEVTMDCQTPSNPYGLKRGYGIPTGEALDMYGILKKTNHGSLAKKYSNNNSGNCSGLTSATVSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDS4</accession>
    <name>A0A8B7YDS4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-microseminoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-microseminoprotein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091409.1">
        <property type="nucleotide sequence ID" value="XM_022235717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDS4"/>
    <dbReference type="GeneID" id="110979693"/>
    <dbReference type="KEGG" id="aplc:110979693"/>
    <dbReference type="OrthoDB" id="9969981at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1900">
        <property type="entry name" value="Beta-microseminoprotein (PSP94) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008735">
        <property type="entry name" value="PSP94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05825">
        <property type="entry name" value="PSP94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034049925" evidence="5">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022091409.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12791" checksum="81749DAEAB16F4D1" modified="2022-01-19" version="1">MVAFTQIVAVALFFLVGADALCDIVSEDVECMVGEMIEKDLRIPAHVSTTCMKCMCIQYKRSTAVQCCSIALKPTGYDELRCEMVLDTEKCIYTVRKIDRPNERCRFSGFIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE85</accession>
    <name>A0A8B7YE85_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box only protein 28-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979422</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090887.1">
        <property type="nucleotide sequence ID" value="XM_022235195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE85"/>
    <dbReference type="GeneID" id="110979422"/>
    <dbReference type="KEGG" id="aplc:110979422"/>
    <dbReference type="CTD" id="23219"/>
    <dbReference type="OMA" id="RVCQDML"/>
    <dbReference type="OrthoDB" id="5860767at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22100">
        <property type="entry name" value="F-box_FBXO28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="36"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090887.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="38484" checksum="A5DA61EA7A11E94C" modified="2022-01-19" version="1">MSDQIQHIHVQKASTSRCGLEPNVALSHSQEKEQIGIGLIELPDVILWQILRHTSYEHMSELRLVCRRFNRVCQDMLSQGSRLLSRYHAKCFKSLKAQLPKRESERREHPLAKRCDILSAVETRLSLLSMTYSKYMDLQLCCFIPGKVIDEAFAVLHHVQHAQDLQPMSELLKELRDISSMAIEHFDEEIVPTLKKKRAYQGPPSLPGEVLPNNNIFKQIIELKMSLKKRDNFTAALSRKVNTCVAHRKLIAEQGQKILQQEQVIAELRTKVAEQCQSLISQERRLALLEERVNRYTMNFDLSPELGVGAGSVKRKETGEDEGKDAGFMSKKSRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEK3</accession>
    <name>A0A8B7YEK3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110979863</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091679.1">
        <property type="nucleotide sequence ID" value="XM_022235987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEK3"/>
    <dbReference type="GeneID" id="110979863"/>
    <dbReference type="KEGG" id="aplc:110979863"/>
    <dbReference type="OMA" id="WIEISMI"/>
    <dbReference type="OrthoDB" id="10195358at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00531">
        <property type="entry name" value="NTF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034334888" evidence="1">
        <location>
            <begin position="24"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4440" evidence="2">
        <location>
            <begin position="46"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091679.1"/>
        </source>
    </evidence>
    <sequence length="162" mass="17991" checksum="96162CD478ACA576" modified="2022-01-19" version="1">MSPSSCLIAFLLVELLVTHPAWAIKKLGQPIFGRAGGDDQTVQQTIEDLDDEWVARVEQNSVDSVMELYDDQCVYMPPGGPSATGHTAVEQLMSWINGVGTVTKTIEEVTRMDGSASYVYHRGNFQATNKNGDTVIDGKELIIWKKDGDSYKIHVHMYNKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEQ6</accession>
    <name>A0A8B7YEQ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-N-acetylgalactosamine-specific lectin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091729.1">
        <property type="nucleotide sequence ID" value="XM_022236037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEQ6"/>
    <dbReference type="GeneID" id="110979889"/>
    <dbReference type="KEGG" id="aplc:110979889"/>
    <dbReference type="OMA" id="CHPPWVA"/>
    <dbReference type="OrthoDB" id="418245at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034981816" evidence="1">
        <location>
            <begin position="25"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="35"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091729.1"/>
        </source>
    </evidence>
    <sequence length="208" mass="23253" checksum="568651EF91E9ECC2" modified="2022-01-19" version="1">MKTSVFTAIAIFLILGRSVKISDGYCPCHPPWVAYYQHCYLVVLEPKAYQSAEDHCLTYSRGVRQCHLASVVNAEEYDFIVNLAREASVKESGIWLGLNDRLETSNFVWTDGSNSSFNRWYHIDEPDASNNCVRTDANHEYRMNDKSCSTKLASVCKALQTLDSPVLLAMLVTNTFSSTDLGAATILPPMCTQAVRLSSNEHSSTVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGE6</accession>
    <name>A0A8B7YGE6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110980198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092313.1">
        <property type="nucleotide sequence ID" value="XM_022236621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGE6"/>
    <dbReference type="GeneID" id="110980198"/>
    <dbReference type="KEGG" id="aplc:110980198"/>
    <dbReference type="CTD" id="29960"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902775">
        <property type="term" value="P:mitochondrial large ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000129">
        <property type="entry name" value="Mitochondrial rRNA methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF18">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="88"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022092313.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32151" checksum="887AD4DFD4F943E9" modified="2022-01-19" version="1">MICLCRVITNVKGASLVNKRTWTEGIPSPGSTEMIPLLVWGRKYFHTPGVLWRSKKPIKLKGRSPSSQQWLSRQVNDPYVKQAQIENYRARSAFKLLEIDARFRLLRPGHVVVDCGAAPGSWSQVAVEKVNALGTDPNKPKGKVVSVDLQYFEAVEGAILLTESDFTHPATQSKILSILNGQLINAVLSDMAPNATGVRVMDHENIVRLCRSTLNFAQDVLREDGHFLGKLWDGHEMARLKEEIARVFRSVKVVRPDASRKESSEIFLLGKGFKRYLIHNVGGIPKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGK8</accession>
    <name>A0A8B7YGK8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110979884 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091722.1">
        <property type="nucleotide sequence ID" value="XM_022236030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGK8"/>
    <dbReference type="GeneID" id="110979884"/>
    <dbReference type="KEGG" id="aplc:110979884"/>
    <dbReference type="OrthoDB" id="6144889at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091722.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="68916" checksum="613C1270C6E4CA5F" modified="2022-01-19" version="1">MLIGHFGSGVNLGTGTDNNVSTLRDTTGTFTCSLPSLSGGGQIKYQSKPRQQQKSTGTQEPLVSLPSHHGNHKKANNNDSRYVTRSVPVHSARHKKDEDRGSSSAPNEVNRHHTNHDRQQRVPMPRLPKINNLLSEPLKQQVHGTSTATEAGRKEIQGGKRWASSWADARANSSSIKETRQVLVLYANQGRNAADNSHQPSSDTIRIAKDSNKIHSPNKSSSPRIPNGSPIKFPKDHEDKFTIKENGEKKAGAQKMKHKNIPLASSKDEPVNLKESKLKSERRTQSSSQIETKTPKYLPNRSKSSAVLTNNREVTRQNSHIPSAYSSSKASSERRDIPQVRVWTTSRGSQSTSTTLTSKPPATQKKRFRKPVIITRKSLVKQKTLQSVYGNKTYKLQRQVRVLQKMEQVQKKEVEDYNRELKEKEKQKMDSVVRQRMALKRVRDKFDEDQVRRFRRQYVSWKSVEEDRLHRSSEVYGLPDFIYEDRYEKTLKETSTVTKKAPKKFQKYATWVRNIKVFEKLLNPTVGGNLEEVFKTNTKTIVEGIDTVKLDNDDSSRPKKVNVKRLIGSAKKLLTVTETMDDISEVSSHQEDDLSDDSLDLSEDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHB4</accession>
    <name>A0A8B7YHB4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110979920 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091790.1">
        <property type="nucleotide sequence ID" value="XM_022236098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHB4"/>
    <dbReference type="GeneID" id="110979920"/>
    <dbReference type="KEGG" id="aplc:110979920"/>
    <dbReference type="OrthoDB" id="10393460at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091790.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="46002" checksum="C749DC7B9C4613F9" modified="2022-01-19" version="1">MEGQTTPIRQSQATPSTLFPSQSSDTILSSGVNKPMSALLADITSLMLLSASADQNNEYDVSGSPPSFLVDLEKTVVDRLKHADEYADIGQDLGTNAAHNMPIYRPMEGKPTMASDTKRSMEHLMLAMAAKPRPDLVSLQSAADCSITDRPLCMTFDSGISSPASALLPGNVETERSLKVDDSTVSKQLHQRLQRLKTFVEQRLQDSSHPRESKCATLSKEIRDRLCTLAKSSLTSSRSESPSAPELFMEKALSSSLLIFENTKLSAEVAYLQKKVEILEDIAATRGFNPEACKPTMETISIGSQTDEQIKQHSTFDETDFGISDFSLTSPETNCLMSTAFCKDGEFPQPSGMSTPGAASNKRQRRKIEVPTQLKVTPSTSYLSIDPWADVDDKQQNGSYTGCWRGLCACFYNSPQARHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHZ8</accession>
    <name>A0A8B7YHZ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-related protein Rab-22A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110980037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092010.1">
        <property type="nucleotide sequence ID" value="XM_022236318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHZ8"/>
    <dbReference type="GeneID" id="110980037"/>
    <dbReference type="KEGG" id="aplc:110980037"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022092010.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26899" checksum="50DCE69A21A3F54D" modified="2022-01-19" version="1">MSFSEELGERKNIISRRASGVSTSECNRSFQCRVSHSVHFDSQNSGVGKSSIAHRFVSETFDDNITNTIAAAYFDKKLCVNGDAVKVCIWDTAGGEKVGIFRALAPLYYRGASGIVLVYDITKVQSFQSLTEVWVPALRANTDSDVSLVVVGNKLDLDETRVVPAEVGRNYAEFLNATFIETSAKTGQNVESVLVQLAMKILEKKQPSTANARQRNLIRLSTTSTDEANSSQKTRRRKCRCTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YI27</accession>
    <name>A0A8B7YI27_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.179</ecNumber>
            <ecNumber evidence="3">1.3.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-xylose 1-dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Dimeric dihydrodiol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110979612</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1R,2R)-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16729"/>
            <dbReference type="ChEBI" id="CHEBI:10702"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18135"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="4"/>
    <dbReference type="EC" id="1.3.1.20" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022091276.1">
        <property type="nucleotide sequence ID" value="XM_022235584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YI27"/>
    <dbReference type="GeneID" id="110979612"/>
    <dbReference type="KEGG" id="aplc:110979612"/>
    <dbReference type="OMA" id="KMIQAPF"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047115">
        <property type="term" value="F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="12">
        <location>
            <begin position="134"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022091276.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="39877" checksum="5DBB92CCA1B00E55" modified="2022-01-19" version="1">MKIRWGICTTGKISNDFVLALSLLPTENHEVVAVAARSEGDAKRFADKHKIPTAYGGYEALAKDANVDTVYIGSWIHTHLPLCKLFLGHGKNVLCEKPLALNKREVQEIIDFAKEKNLFFMEGWWNRFFPLNVKLRELLAAGHIGEVKCVLGSFGIPKLKDERIEHKEFGGGAMLDMGIYLIQTTLMVFDRAPTSWSTKGFLAPTGVDETTVTTILFPDNAIASLTCSVAVFLPNEIEIRGTKGYIKVLSPFWCPLKMEVTTVVQKSDDVLDIEEKQEVMEFPLPSNREGFVYPNSAGFQYEAEAVRQCIIKGLKECPTVTHKESLLAHEILQSTRYDVGYVLDVDKQKITTMPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJ71</accession>
    <name>A0A8B7YJ71_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Vacuolar protein sorting-associated protein 37B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13" type="primary">LOC110980702</name>
    </gene>
    <organism evidence="10 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093297.1">
        <property type="nucleotide sequence ID" value="XM_022237605.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093298.1">
        <property type="nucleotide sequence ID" value="XM_022237606.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093299.1">
        <property type="nucleotide sequence ID" value="XM_022237607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJ71"/>
    <dbReference type="GeneID" id="110980702"/>
    <dbReference type="KEGG" id="aplc:110980702"/>
    <dbReference type="OMA" id="AMYSSHS"/>
    <dbReference type="OrthoDB" id="10004364at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF27">
        <property type="entry name" value="LD45836P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="174"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="255"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022093297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022093299.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37855" checksum="6F5518F777BE44C5" modified="2022-01-19" version="1">MSSYSSHNYPYQIGSHQPPAQPPQYSSYTPQPTAHFPQPQLQYPQPPSFPTPSPSQPEPPRYPQHTPVDNVPVSMPLLQRSEPDRSPGSQEIGDPRFVLLYSMDSEELSALLEDEEKFSEVVTNMEEVKQKKLEKEMAMAENRSLAEFNLSREPRLNEGRAQLIERLHEAQKIRDSYIMGKAKLESVREQTSLDAALALMQADTAKAEDDSEEIADDFLKGDLSVEDFIEKFMPMRQTAHLRHIKAEKMQEILNKQGRGQTATSSAPQGATSQHSSMPPYGQPHHAPPSMSHYPHNTHGAPPYSYQPQRPAPRLPYQGPNYGPGAPPRMPTLGSYPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJC2</accession>
    <name>A0A8B7YJC2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110980272</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092505.1">
        <property type="nucleotide sequence ID" value="XM_022236813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJC2"/>
    <dbReference type="GeneID" id="110980272"/>
    <dbReference type="KEGG" id="aplc:110980272"/>
    <dbReference type="OMA" id="FANDYYF"/>
    <dbReference type="OrthoDB" id="10042460at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092505.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="45666" checksum="8D4F9899B06BAEFC" modified="2022-01-19" version="1">MQTTDGCIVCRNMWWDSEGICRPYTEKDIGAREWIHRGSTVLSIIWVLILFGFTLYEMTLRIKYLGGQKKELVPFINFATHNIFNMSIPAFVLLANVRHLRMDRRRLRRVEGFRWWKALSIRFIVRRLQHLEMRNRRMPHKAFLIICLVWPLFNGMYSLILFVTRLKSSEETVVSLVFSVLCMIVWGVFCYLVLLLRLSFLQQQRLELGFLWRHAGKLDVCRRQLSMYVEDLGCLRQLVSGWIIVVVAVSSWAFSSMLYWEYVVISSRLKVKRDYFFEFNFNLWSTNIMFLSLPLLAVGGMELKGMWSRFKYSISQMRSESHDAFWDKILAYCEERSPTTRVKMLALMVSALGLFVGLHLSVEDQDVNMPIQNELFTLFYHINSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN89</accession>
    <name>A0A8B7YN89_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein salvador homolog 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110981454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094734.1">
        <property type="nucleotide sequence ID" value="XM_022239042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN89"/>
    <dbReference type="GeneID" id="110981454"/>
    <dbReference type="KEGG" id="aplc:110981454"/>
    <dbReference type="CTD" id="60485"/>
    <dbReference type="OMA" id="AARYYYP"/>
    <dbReference type="OrthoDB" id="5339429at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21433">
        <property type="entry name" value="SARAH_Sav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000035">
        <property type="entry name" value="Salvador homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011524">
        <property type="entry name" value="SARAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50951">
        <property type="entry name" value="SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="SARAH" evidence="5">
        <location>
            <begin position="279"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022094734.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="38941" checksum="B1FF1BF7960B0A1E" modified="2022-01-19" version="1">MILSRKKDSSKPLTSEGIAGKYTKRESSPILQSYMSPVVRHGPSTSRRQTPPSSMQHSGASSHDAPVPGAGRYSRSPHSSAQSLTSSAEDTGVSSYSSRYTSSVASLPSRGQYVQDVAPVSSSVGNLRHPPLPSVNLAHPLPPGWTVDRTMRGRIYFIDHNTQTTHWSHPMEKEGLPAGWEKVESPEHGVYYINHISKMAQYHHPCARNIPRYEPPPPAPKQLPITHPHRGGGGHPHAPGADEHPGGQHVWVPANPYLYAQIPDWLEVYYKASPKHDHKLKWELFRLHELDAFQGMLSRLCKRDLEEVVMDYEAYRFALLREMDQRLVRSKKMQQQALQQPSPETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YP45</accession>
    <name>A0A8B7YP45_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110981631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095038.1">
        <property type="nucleotide sequence ID" value="XM_022239346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YP45"/>
    <dbReference type="GeneID" id="110981631"/>
    <dbReference type="KEGG" id="aplc:110981631"/>
    <dbReference type="OrthoDB" id="9972587at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF41">
        <property type="entry name" value="UNC5C-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="4">
        <location>
            <begin position="187"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="478"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022095038.1"/>
        </source>
    </evidence>
    <sequence length="797" mass="89297" checksum="230E508916753743" modified="2022-01-19" version="1">MQLYQQRILRVQPCCLHTGIPSSMLDDKYFRQLASSLGHEWLKLASYLDFSRDVIDRLQEDYRRAEECIFQMLVSWRQNSDWRLNNSLKLQGALVKCGRRDLADQLQDICLSDGFQQVVTLSDFSEESDGRPFEENRIQHIESNQHCKCIKRMNSIEHLQMLRAEFHQRFAHLHGMDRLGSLCHLVDFVAGYFDFYGGTLGLPEYDVHLYIPQGAIPSGKIEEVYLYVNPMVQSVSGLHSRALLSPLVECGPSGLKFLKSVVLHLPHFATNGGTGWDITAGVSYSESEDTHSDDWNNLSPDENSNLIINQQQIILALDHFSTYAAIGTPFNEDCGKTMKIYISPINSPTDSLNVHVLIWNNINITRQCVIRSHERLAFGVLDEACYLNVTWHGGDLMLQLNNTCPGYKVETTKKRIAKEVLWENQVHSVTFDLSVDTANHSGAAKKEWDGQQLCNVDIYQRSWGPSRSPVHLSVHHPHANKADVSAKGKQKTVDHSKTRTGSKSERKRNFPESLTTGERNSSQTDDVLPWKFKISVDLGQTDCTDGTSHLLRGIAAYRSGEIVVSDFVNNQLVICNIKNVVQAKIPLERVWDVAVLPNNNLVAVDETSEVKVFTENHTLAFTFTTKPAAVDKAQVGLVSAAVGEGGNIFIGDAFSNVVSEHLPADGTLVGTRKLHVCPHFLAVNRKGQLLVSGWNACKVDIMDDRNVHIVIQTIHPTIRGKPAWCLGVCCSTKDDIFIVVTSSNDRLGHVHRYNTQGDFEECIVKGLHKPRGIVCIDDTKLAVANDNTVMLFEKQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPH7</accession>
    <name>A0A8B7YPH7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110981688</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110981688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095179.1">
        <property type="nucleotide sequence ID" value="XM_022239487.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095180.1">
        <property type="nucleotide sequence ID" value="XM_022239488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPH7"/>
    <dbReference type="GeneID" id="110981688"/>
    <dbReference type="KEGG" id="aplc:110981688"/>
    <dbReference type="OMA" id="LECRFMI"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270:SF5">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46270">
        <property type="entry name" value="ARMADILLO-TYPE FOLD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="562"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022095179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022095180.1"/>
        </source>
    </evidence>
    <sequence length="819" mass="90738" checksum="21D40BD706F85C17" modified="2022-01-19" version="1">MGSAASSARNRPPTPQSARIPTVPPATDQHADAAGQNTSDDSAKYPSQTHEDGRGPEPMANNGSLSSDPSAKQSPSGISQSQSAAASKQEASASPTAISDPPSVTLTAVKSKPSQEENKSKNKNSLKDENIVLKCVEFLKQATNTGGTVAPCSPADPSAFEKNSGRREALRSNFLNSLEQLREVEIYTDDSAMADLLNVCQMSNLTDPETADELVEEGYPDLFLKIWNGVYHDDIYTSKEQYRQYIVYNLLKQASINFTHVSRKLCGAMGSSERGIVPLVAKEFEHPLMKLEALKDGVKKALWDSPRETLKKTINILANIIRGDIDNKLVFRQANIVPHLKALLECRFMIMRAKALLCLVYLINEDENEALNTTDDNIDFVIKVLGKCLNEKGHYSEHYTFSAEVVVDGIVYLAGNDSNKLKLVKKGVIDKLITMLRTERVGEKHAAAKAVWKLAFHEDNKKQFKTNDTLITNLKELLSHESDPGLLKACKTVLWMLDYTFDNSESCGRGSRPLTGKHRARPIATADNEKSEDKPDDAEKGGDGEGLDLDDDDDFGDEVPHVMISYQWGVQKQMIKIKELLKESGYSVWMDVDNMGGSTLESMAAAVERSAVVLICFTEKYKQSASCRTEAEYTYKLQKPIIPLRLQEDYDPDGWLGIMIGAKLYVDMSRANSLGEDFTKLKQQLGGRGRMLKEGLHNTFNSTLQDSHNASGTQKDVSMMQRRPPTQRSTNVKTPGSQEHTDAKTVSTWTNDQVNTWLAKHGLGGLKNRFDGYNGQRLLGLKTISTEAPNFFYSEIKNDLGFKNLLEIVTFKQALDGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSN3</accession>
    <name>A0A8B7YSN3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein outspread-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095475.1">
        <property type="nucleotide sequence ID" value="XM_022239783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981830"/>
    <dbReference type="KEGG" id="aplc:110981830"/>
    <dbReference type="OrthoDB" id="9942268at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052223">
        <property type="entry name" value="Actin_Cytoskeleton_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17271:SF1">
        <property type="entry name" value="PROTEIN OUTSPREAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="82"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1375"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1505"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1610"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="623"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1540"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1387"/>
            <end position="1396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022095475.1"/>
        </source>
    </evidence>
    <sequence length="1685" mass="189063" checksum="C49E378CF79AE0BD" modified="2022-01-19" version="1">MLDGDSPSPSKRTIDRRKQANSRRSRHTVTIDSSMHVMPSSDESETNKETPTLKRSSSDPNLADSDDMLKRKQIAMTFPGLFHLKKGWLVKQGDGEQDWSKHWFVLCDNKLSYFKDSSDEDPDNLEGVIELAKCIEASETPVSRNYGFQIELDTGVIILAAMTSGIRNNWVGAINKAIKTAREDSAKKSGESTTPLKENQALPARITKPNSLPISKSTSDIRPKEQRSSPLQPARKSLNGADLLPTTSRSLTQTDGKVGTPSPGEPKPLLERKSSTQSQSTKAPSLETLPPHSGKPEGRRSSVSKPSSSESRPRRGSVTKEGSSTEARRNSVTKEPGIVTDGKQKHSSPTKENSGSDSSKSKEKSKERRQRRGSRSERRSREESTAAVTAALSKRTANTDSKQSTTARKSRSSSQTEEPVTSSPNSEQDISPRSRADSESKKRPATVDTTVMSLLEQEVDTLKAQLEQKQQDCVRLQHENVNLKAKLNSEQRDHKESFQDLENERSGYMTQIEQMEGINQKLQTELRQSKNATQQLEQQNQQLDGQVSTLKTEALGRDQDLASLKARFEDIVRDLTASKEENALTRAELKAERERSETLETDLTDTWVKLRESGSEGVDVDVVEELSLKLDEARMRLERSESDAVENEKKFEERLSRMENQHQTESTALQERLRAALDETSELRKRVAEKTEQIQKTEAAIEKAGQTDKLSLETNARVAELEGAIRELKSCLKREVAAKSEVQKKYDDLLAQSAHQFLEGQGDLASTGSDDNAVRLETELDLAERELEKLKKQNVVDKEQRASLEKALEREQGLRKQMEEKMSLSTQESGSSKVDIEQKSSEIASLREELKKAKKEREAVNLVRKQLATAVDRLNNQLAEKESKLETLSAEVETRGSQNSQLEQQLQVSLSKGLNLQSKVETLEADLQQASEKRDADASAQLEALQAEHRQLKRQIGILEEQHALEMHNRQSELVTAGDRINRLEEKVVVQETKLKAATERADRIEDDAAANILDMQKEEELLRSKCERSEKEVKRLRGELHAAQDNYDELELQFITQREDLKRMEKEHEKEIGQIGYRIQDLTSKLAASERKVRDLKGVDHRNRAKGGVGAAGGMGMQLTQTRQMENKLKELESKLGDVESTLQDQDQDTTSLLGKIVSVEQQVQARAQLPSTSSCADTEHPLQSQVVQPLSRGSSAASAPCDSVSTSGADLSEDSESTEGAASPGRAKQTFRARYLETKLSGTEEKLKEVTRKLVDVTTRELEIRKTYQEKSVSESRLKERLKVMEREVEAVTKELQQARNNGDLVLQEKSHREILEEMRRSHNQEIKALEEEKEKELDEERKATKITIAMMKKTHKDELEKEKQMLRQMLSKEGGAPLPPLAKKDKKHVKPSKRATGITALHKAHKQELEQQRADMLQNVSNDVEVVMKRHREVITKMDQEWQIISDKFTHVCAENNSLKKQVETLQKSLSESLQELKSWRAQVRQLIGQKAEDMAALKEQIGEGSRGGSDGDEGGNQEDWGVDSNDNERNPLQVLLRFREAELKCTNDEINQLTEAVEKAERQQTKVLEQNVFLEGQHQSQEEHIKQLMVALEELQHQVEVVRTSGEGQAAQDQVAETEAASAARSGHGSGEAKQDVRLRSWIPFLKRERSDSTGKGSRRRAGSDGTQSAAKLKKGAATTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSZ1</accession>
    <name>A0A8B7YSZ1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cystine/glutamate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Amino acid transport system xc-</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Solute carrier family 7 member 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">xCT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110981301</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cystine(out) + L-glutamate(in) = L-cystine(in) + L-glutamate(out)</text>
            <dbReference type="Rhea" id="RHEA:70995"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-acetyl-L-cysteine(out) + L-glutamate(in) = N-acetyl-L-cysteine(in) + L-glutamate(out)</text>
            <dbReference type="Rhea" id="RHEA:74567"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:78236"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)</text>
            <dbReference type="Rhea" id="RHEA:71191"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc; this interaction mediates cell membrane localization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094471.1">
        <property type="nucleotide sequence ID" value="XM_022238779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSZ1"/>
    <dbReference type="GeneID" id="110981301"/>
    <dbReference type="KEGG" id="aplc:110981301"/>
    <dbReference type="OMA" id="WLENFMI"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015813">
        <property type="term" value="P:L-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043067">
        <property type="term" value="P:regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000027">
        <property type="entry name" value="cystine/glutamate transporter isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF375">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00078584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022094471.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="54022" checksum="48E9118354633037" modified="2022-01-19" version="1">MEKRKSEKNGTKPGEGKDDAVSSAGSSDVVVLRREIGLWGCVSVCVGIMIGSGIFISPKGILQNTGTVGMALIVWVLTGLMSGLGALCFAELGTTFTKSGGEYAFLLEAFGPLAAFLRLWANIIAIGTGTIAVLAITFANYALAAFFGDCQDVPMTAVRLVAALILFVIFYLNSVSVTWTTRVQVFLTIAKVIGLTIIIITGIVLLFQGKTEHLENAFAGSENTDATKIPLAFYSGLFAYAGWQMLAQVTEEIQHPARNLPLGVMLSVAIVMVVYLLTNVAYFTVVSPQELLISKAVAVTFGERMYGSMLFIIPLSVVLSCAGSINGSLLSDSRTTFVAAREGHLPLILSMISINKRTPLPAVLLMLPICLIMLTSNNVYSLINYLSFAKWLFLGLSAAVLPYMRWKRPDLPRPFKVSLIIPILFILSCLYVVIVSLYSAPMDCGIGLAILLTGVPVYYLCIWWEKKPVWLENFMITSTIRLQKLMLVVVQEKETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YT28</accession>
    <name>A0A8B7YT28_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein Hikeshi-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPI10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096444.1">
        <property type="nucleotide sequence ID" value="XM_022240752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YT28"/>
    <dbReference type="GeneID" id="110982386"/>
    <dbReference type="KEGG" id="aplc:110982386"/>
    <dbReference type="CTD" id="51501"/>
    <dbReference type="OMA" id="WWAKFER"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048364">
        <property type="entry name" value="Hikeshi-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008493">
        <property type="entry name" value="Hikeshi-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031318">
        <property type="entry name" value="OPI10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925">
        <property type="entry name" value="HIKESHI FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12925:SF0">
        <property type="entry name" value="PROTEIN HIKESHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21057">
        <property type="entry name" value="Hikeshi-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05603">
        <property type="entry name" value="Hikeshi-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hikeshi-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Hikeshi-like C-terminal" evidence="3">
        <location>
            <begin position="139"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022096444.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22437" checksum="7BDCC9A60387C1A8" modified="2022-01-19" version="1">MFGCLVAGRLVQTDMQQVDPTHFVFNIENADTVNHIVVFLTGTMPFPDGMGGAIHFSWPSSEGVAWRFLGYITNEKPSAIFKISGLKKGSISNDNPFMQVIQQGQQMNTMSQIGIAVEPITQIAQQIPAENTQTSNMSNFAEFTTKMLENFYNYASSFGITQAHMTSQPDVTWVPLTVLNQWYENFKRKMTQNTNFWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTG4</accession>
    <name>A0A8B7YTG4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alpha-2,8-sialyltransferase 8F-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110982477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096588.1">
        <property type="nucleotide sequence ID" value="XM_022240896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTG4"/>
    <dbReference type="GeneID" id="110982477"/>
    <dbReference type="KEGG" id="aplc:110982477"/>
    <dbReference type="OMA" id="CHREVIN"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23963">
        <property type="entry name" value="GT29_ST8SIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF54">
        <property type="entry name" value="ST8 ALPHA-N-ACETYL-NEURAMINIDE ALPHA-2,8-SIALYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022096588.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25688" checksum="A1F5B92974EF8C93" modified="2022-01-19" version="1">MLPKESPFAKVKLERCSVIGNGGILANSYCGKKIDSSDFVFRCNTPPLKGYQKHAGTKSSLTSINPGGVIDVKYRRLKDIGYRTKFLRDMKAYGDLLIPAYGVNMPAYRTSMLALRLLRQNRSTTRGLIINPDHFRGLQDLWRRMGLKSRMTTGFYLASVALSVCNSIELYGFWPFAKGPKHRPVPYHYYDRLKISKGVHNFNWEFDVLYQLHMGGVLQMHAGPCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTI7</accession>
    <name>A0A8B7YTI7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110981413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAPIN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094666.1">
        <property type="nucleotide sequence ID" value="XM_022238974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTI7"/>
    <dbReference type="GeneID" id="110981413"/>
    <dbReference type="KEGG" id="aplc:110981413"/>
    <dbReference type="OrthoDB" id="5399166at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017246">
        <property type="entry name" value="Snapin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31305">
        <property type="entry name" value="SNARE-ASSOCIATED PROTEIN SNAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31305:SF2">
        <property type="entry name" value="SNARE-ASSOCIATED PROTEIN SNAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="48"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022094666.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="17139" checksum="DCA11EDEF4AA7E97" modified="2022-01-19" version="1">MAATMTAETTSTKQPAISPTENRDAMAAGILELLRPAVQEVDERVRLVRESQLDLRQQIEELDEVLKQLGQSREPPIELDPYVKKLMNSKRKIAVISNIVQNAQERVRKLQQRIGKESGKKLSHLYPTSTEAVTLPAGMVGATLPPSEGEPAKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTU4</accession>
    <name>A0A8B7YTU4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LOC110982174</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Receptor for basic fibroblast growth factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022096117.1">
        <property type="nucleotide sequence ID" value="XM_022240425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTU4"/>
    <dbReference type="GeneID" id="110982174"/>
    <dbReference type="KEGG" id="aplc:110982174"/>
    <dbReference type="OMA" id="VSCEVAI"/>
    <dbReference type="OrthoDB" id="10045779at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000593">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.100">
        <property type="entry name" value="Glycine betaine-binding periplasmic protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="18" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="810"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="872"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="904"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00056965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022096117.1"/>
        </source>
    </evidence>
    <sequence length="1015" mass="112609" checksum="73F3366E842CA555" modified="2022-01-19" version="1">MPPKHTSRPGVNPSVDFTNHVIKTLAMEILGYQDVRILNAEVDFHNSTVALQRISGCYDYSCRAIWIPNDASNATINMEVWQDNLLEMALWSETGTIKVNGFLGYTARYGWFVSQTLVAEMWEQHQIIADHWKSLHSQTVIRKLLIPLSELQGLVTIKSEKPWGKETRYYCERAECIQGMYIPPVCQGTDSTTPTAECPTLVAGYPDTSFDMLIGQIVSLRLPVVVAWIGPQLESYISTRSQTHRHTLFLSWSPHALTSSGLFNRVSFPTCVEGVSIDANSGCDFRTLPVSKVTWLPLAHGAPDLDEMISAMSFSDFEMQVILRKFYHSSGNMEAFACDWLKSNTDIWNGWLPNQLNPRKKIYLGGLFPDHIPAFSGIGIGAKLAVEAVNTDSSILTTHELELVVDGSDGSDAVASYLRLQKDNTKPLTGVIGPMHSEDCKIIAPIAALFRTVVISYGVESPALSNRDFYPNFVCMLPSAAENAYALARLFETYSWKRYAAISDSEVSSLEVMTTTEGILGEQGITLVASQSFTDPLLLNPALFFDDIKNQRAHLVVGLFSDVAARVLLCEAYKQDVTGYEGYQWFLPALYPDHWWDTDFYNSDRQESPESVPCTTQEMARAVAGYMSLSQLHVARGEECIVSGETAAQWEEKYQAVVDQEGKQASDFAAYAYDAVWAFALAYESLLQKSPGALGMSRHYRDISSFMSHLSKTRFLGMTGEVTFAGSDRQGPVLISQHLPQRSTVSMPVGLYIPFVANSSEWTGTLQLNTSDIVWLNDGKIPDDGGIDEGDCAVESFRVFLGVDCQSATAILNAFLIIVVFIILVVCVVLVKKAYNRKVKKAGQKVKDLGITALGQSTLLSLNKWEVAQDNVILNRKLGEGAFGTVYGGEAMLDGNHWVGVAVKTLKVESTIEEKLDFLSEAEMMKRFDHKNIVKLLGVCTRREPLYTIMDFMLHGDLKTFLLARRHLVSQGQVDDSSMSPERLTSMVLDVATGVSYLAANKYVHRSVQGTSEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTX8</accession>
    <name>A0A8B7YTX8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Scavenger receptor cysteine-rich domain superfamily protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110982203</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096152.1">
        <property type="nucleotide sequence ID" value="XM_022240460.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982203"/>
    <dbReference type="KEGG" id="aplc:110982203"/>
    <dbReference type="OMA" id="DCNGNMP"/>
    <dbReference type="OrthoDB" id="532981at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034955975" evidence="13">
        <location>
            <begin position="30"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1356"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="49"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="161"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="274"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="386"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="504"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="614"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="730"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="859"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="990"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="1107"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="14">
        <location>
            <begin position="1223"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1330"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1435"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1438"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="299"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="312"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="529"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="542"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="949"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1178"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="1297"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022096152.1"/>
        </source>
    </evidence>
    <sequence length="1480" mass="162183" checksum="5C7781B68CB16480" modified="2022-01-19" version="1">MEPTVYRFFEPHLVLFVCVVAGCAVPSHSLESDVSSGQETTTATGKLQVRLSGGFTPNEGRVMIFAEEQWILLCDADWGLSEADVVCRQLGYGYATMAWRGAHFGEPKGIGDESMITLSCMGTESELSACSHRRISSEICGKFKTAGVRCVNVSVFKENQVRLIGGITPNVGRIEIFQNGTWNLICRESWGVTEASVACRELGYPGALADWGKTWIHLDRAAILQKSVAFVSCSGVEDKLSKCKVGTTRNFHCQESATVSCSAGDRNGPLPYEIRLTGTDQPNKGRVEVHLGDSWGTICDQSWGLKDATVVCRQLGYPYAAAAPRGAHFGQGTGQVLLGHVGCSGHERHLLECPRSGIGATGCLHDRDAGVVCSLDHTVNLPGTIVRLSGGSSGFVEFFHDGQWWRVCGHGWDQNDASVVCRQLGYHSPTNISPLTFKSTTWSGDSEEENVAALIDRMRCHGNESSLALCQNDVLGPKTCQTSMAAVDCNGNTPPRSIEPANSVRLADGVYPMEGRVEVYLDGAWATVCGDRWDMTDAEVVCRQLGFNHATAALIRAHFGPGSGPIVLDEVDCVGDEEELMDCQAKKWYQHDCQHRQDAGVRCDSRQVSQDYSIRLSGGATPNSGRLEVFLNGLWHTVCDVAGTWDIREAQVVCQELGFPGALAPWAKIIGVLNGARSRRSFESVECLGNESKIAQCRLGLVGGLDCGGVEHEARVLCASRPLENLPYSVRLEGGNNDREGKVQILQNDHWLPVCGDDWGIADARVVCKQLGYQFAKSATIVPEDFSKEQRQLRTENNRAKFKRSFPHVRGLSGFRCTGHEDHLLQCHYRDGQMVGCARGVVAHVVCSDKPSIPAGERLRLSGGTGESEGRVEVYFEGMWWKICGDDWDIRDANVVCHQLGYSSDLAVYKLSDSLSNDVICENPADESFGDLVKNVDCDLEYLMSDLQCTGNETSVVDCRHAGFGRQYCSGDQDAAAWCDGKRTKQIFEARLGASDPRRPYEGRVELNHGGRWWFVCKDGWDQHDATVLCHQLGFPGVDSADLQPSYRVRGSSEGVGFLLDDLQCDGTEDNIAECLHSGVGRERCTRRVAAGVRCATDLLMIQGEDIRLIGGNTVLEGRVEVYHDQRWWTICDDKWDIKAAGVACRQLGLPAAESAVFGAYFGKGREGTGILLDEIDCKGSEGNLLECAHHVLGEHDCNHAQDAGVKCSPPTVHHQLKLPKPVRLAGGSNISEGRVEIYHEFRWWTVCKSGNESDDMNAALVVCRQLDFTSPRAVLPVDQFQAAPSYTRALFTLLLCKGWERNLSLCRHEELSLTDQGCEHSQELAVRCTDGNGSGSSPPWTSPTRRKRSGPTTPVLAVIIATVFVTGFLIGSLILYHVYKACNRFLSRHPAIISGDAVRSPRTAANLDRPELAREAKESSRNKDMFIELYPLAPVPDCEDTDTDGDEENEYSDWGSTPIRRETNLPPHTPDVTYDGTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUK2</accession>
    <name>A0A8B7YUK2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096968.1">
        <property type="nucleotide sequence ID" value="XM_022241276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUK2"/>
    <dbReference type="GeneID" id="110982681"/>
    <dbReference type="KEGG" id="aplc:110982681"/>
    <dbReference type="OMA" id="TYYWPEF"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="47"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096968.1"/>
        </source>
    </evidence>
    <sequence length="431" mass="46964" checksum="A500B7D2DA0381FF" modified="2022-01-19" version="1">MAFIKTAFLVCATAVLTVYLPQLWTTTRPIITAGTVQPGFEPVAKLFRENFENGVEYSTGGSAYSVYYKGSKVVDIWGGYADSEADRPWKEDSVAVFYSTTKGIAGICMAMLVDKGLLDYDKTVASYWPEFAQNGKDNITVRTLLNHQAGLSYTPEKMSLALLKDQDALGNVLARAPPQWKPGTAHGYHAMTFGLYASQLLRRVDSKHRTLGQFFKEEIAQPFDVDFHIGLPVESFHRVARLVGHSGNFILSLLKGLSSPLNRQMMWAMATGKSDLPKILESSGDTLEPEAFLRPETLALEQPSAYGVGTARAVAKVYGILANGGKTKEGKTLLSSKAIKKIISEAKDDGSLDKTVGFPAVINLGFFISEYEGSPQFGHPGAGGMQGRADPQRKLGMSYLSSYGSQFGLGDDPRFMSLQAATYKCIDKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUW4</accession>
    <name>A0A8B7YUW4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110982278</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096275.1">
        <property type="nucleotide sequence ID" value="XM_022240583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUW4"/>
    <dbReference type="GeneID" id="110982278"/>
    <dbReference type="KEGG" id="aplc:110982278"/>
    <dbReference type="OMA" id="QQVMYCA"/>
    <dbReference type="OrthoDB" id="10384927at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034733235" evidence="1">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096275.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18286" checksum="0C2DCB0A8A435EBF" modified="2022-01-19" version="1">MARLKLAAIILCLIIAKSEGLWKDGGDDRTYGNMGYYTKNMTCDDDGSTCEQCFVARARGKIFLHTVEYTANPYTLQLTQLEGDDEWRLNFAQEDASESFRLCTATDYRGRELGTEQHLSVCLENFSTGYVAPAGCTKPVALVTLADRFSNLRMSGQQVMYCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVX4</accession>
    <name>A0A8B7YVX4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Rhodopsin, GQ-coupled-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110982608</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096847.1">
        <property type="nucleotide sequence ID" value="XM_022241155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVX4"/>
    <dbReference type="GeneID" id="110982608"/>
    <dbReference type="KEGG" id="aplc:110982608"/>
    <dbReference type="OMA" id="RIFIFIR"/>
    <dbReference type="OrthoDB" id="6435638at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="49"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022096847.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="40050" checksum="0F11877F98096DE7" modified="2022-01-19" version="1">MDFSAVLNETYGVTSANSSDGVKSIYSAYLERQILSGFGFVVGAVGFFGNLAVITAILSFKRLQTRTNVFVLNLAVADVLTCTVSPLQALTVLHDELVIPPWSCKLVAFCLVTCIGCSINTLACIAVNRLVRITTMAMYHKLYTPFKLFLMISVSWCVPIAVATIPLFTDHAEYGFNNVYKSCTWESKTSYDLTYAKLIAIMFFPLQFTILFASYLKIYVYVRKKTQSMLRLSSSGDTIGSGSQAIQRQLWRRQVAVTKNLFLVVCVFLLCMIPYFATIGLPIPVIRSLLSYAAAILMTNSSLNPIIYGTKHPDFRMAFAYILCYRRKRHHLGPKVTALSGQNRSDTRTIAANMPQQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWF5</accession>
    <name>A0A8B7YWF5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110983052</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097649.1">
        <property type="nucleotide sequence ID" value="XM_022241957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWF5"/>
    <dbReference type="GeneID" id="110983052"/>
    <dbReference type="KEGG" id="aplc:110983052"/>
    <dbReference type="CTD" id="1528"/>
    <dbReference type="OMA" id="FMFEHKS"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0349">Heme</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="7"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022097649.1"/>
        </source>
    </evidence>
    <sequence length="132" mass="14502" checksum="739D5DAB40E4C264" modified="2022-01-19" version="1">MSEKSETKVYTLEEVNKNKTSQSIWVVIHNKVYDVTKFLDDHPGGEEVLLEQGGANATESFEDVGHSSDARELMKDYLIGDLAEADWETSIKTNTGPNAPEAPSGSNLAQWIIPTIVALGVALLYRFYIAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWS2</accession>
    <name>A0A8B7YWS2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tenascin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110982782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097142.1">
        <property type="nucleotide sequence ID" value="XM_022241450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWS2"/>
    <dbReference type="GeneID" id="110982782"/>
    <dbReference type="KEGG" id="aplc:110982782"/>
    <dbReference type="OMA" id="SYFGVNC"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.300.10:FF:000003">
        <property type="entry name" value="tyrosine-protein kinase receptor Tie-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006585">
        <property type="entry name" value="FTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391">
        <property type="entry name" value="INACTIVE TYROSINE-PROTEIN KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26391:SF18">
        <property type="entry name" value="PROTEIN KINASE RECEPTOR TIE-1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22633">
        <property type="entry name" value="F5_F8_type_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00607">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1117"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="387"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="676"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="774"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="871"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="972"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022097142.1"/>
        </source>
    </evidence>
    <sequence length="1176" mass="127162" checksum="4970E6C0662A1134" modified="2022-01-19" version="1">MTSKHGTRRQWLVQCLAVFWTVVVYRPTLAVYLVGRPSSQTSTFKESTPAYKGVDGVPTSCAITRAAEHPWWRVDMLQEYCVGAITVVNRADCCAERLVGATVRAGLSPTISENTLCGSPVSAEQATPGAWLRFTCDPPVQARYVSVDIDLEGTGRTQFLTVCEVKVEESTAWDCHDWTANSTGFLDATCVTPTPLLDPSGDTGAFIGTYLGVQDATASVSFGRISQTGHTGNPALPTSALQVSHPLDATDAELLYLPRSGGLLRIGAFYCLARKDETTTKIAIIILHKNENIVHIRPVVLTKTINVMESATLEMRTVNPPTSDIRWRHNGGPFIDRSQGKLNHYIPSACLGDSGIYECHVNTFRPLQLHGIMKLIVRECPSGRWGPDVSCSKLCPPCYNGGICDAISGRCVCAPGFMGRYCEEVLGRDVFGQDGSHYCHGSDDSQSNGCRGKLFCLPDPYGCSCAAGFKGFDCMQECEEGTYGADCKQTCHCAPSVVCRKDTGECQGACAPSYFGVNCQQTACPVGFFGTECNQVCHCQSATCHRDSGECDGPCAESYFGVNCQETAYDGVPDLVAYPSGANPGHLILSWGKDSAAFYTIAYELVNRGHCQPITDPDRKFHPDRLDRNTSHFILTNLEPSSVYKVYVQSHYGIHSMLPAESFVVVSTFQANDSQVVKDFRVVDVTSSSFLLSWRPVQCATGYHVTSDLIQRGNCSRSEFPQERSAVMTPDTSVTIACTEPFATYNISILATVGDVNGSTSTLQVMSSPAAPGTPESLSLVSSTPSALHFAWNDLPCEEQHGHFHGYCFALRDTSTGDTVASDTTLVAEVGFSGLTPCRQYDFRVASTASGLQSPYSPWLNVQTAVQEPGPVNNATVGDSSSTEITVSWQPPLVNSCGVSGYKLRYVLTIHDMCSKTTLPTVSMDTVSTNVRLTGLIPASQYQVFVKATNSAGEGRETSVLWTTDDSVPTDPPQDIMVFLISGNNSIGFSWSQPSCGGRGGAIMQYSYRLTHMIDGLPLTDSTGDTAREWVVISGLVPFRQYSFQVAARTTVGIGPYSQIVQATIKRGQDANLLPTVTGFSSSAAENRMVTPSSKLSDEVHVTPKLSAKSVGSGSGITATVTAVVLTGLVLIVVFVVVFIKLRRSRGRLQLWRHGRLTNCENDNAEIETEMKSRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWX8</accession>
    <name>A0A8B7YWX8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dual oxidase maturation factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110982691</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DUOXA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096990.1">
        <property type="nucleotide sequence ID" value="XM_022241298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWX8"/>
    <dbReference type="GeneID" id="110982691"/>
    <dbReference type="KEGG" id="aplc:110982691"/>
    <dbReference type="OMA" id="FMVIRYC"/>
    <dbReference type="OrthoDB" id="10042652at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018469">
        <property type="entry name" value="Dual_oxidase_maturation_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158:SF1">
        <property type="entry name" value="DOXA1 FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31158">
        <property type="entry name" value="DUAL OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10204">
        <property type="entry name" value="DuoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022096990.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="52965" checksum="427C6CD242A6C0E9" modified="2022-01-19" version="1">MGTPYSAFRNPGVPAIYGPNKTAVTADVTFAGFLFAFIIVAISFLIILPGIRRRNRIYAAVRFFVGMFIGLAIILSTYGQEWEVSSQRNVTTAYKAFTKDEIVADIGVNIGLTNVNVTVKGVPEYPEEGGLKGERINYNERFTFCCVQGRRGFGPFAGPINREFREAQWKGLPYPILWIAEYFTLDGEGIRWGRSYRTAGFYTFMVMGTSFCVWVLALVLSFMVIRYCGVFLLLTGCCLLSSNVIYATVRYGSDLVIPFGKDHVLEFSKGSSFYLCLTGGIVSTLVGIAIVVLDDLFPFKTAAFFNVDPLQDFQDTFALSPSSGTNDRHGEGDRPVSVLNEDLRVEALAVEARDKRESEAYRGNLYISVAEMKSSFKSGRKTLFQKNKPRRKKKESEDLCNVNLGFGPDEGSSGNTSSLHRLHPEPRSFKVKNMGETTVGDTVATDPVYLNISSIRMSEIAQRNEVELDEEWSAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY95</accession>
    <name>A0A8B7YY95_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox protein Nkx-3.2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bagpipe homeobox protein homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NK-3 homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098314.1">
        <property type="nucleotide sequence ID" value="XM_022242622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY95"/>
    <dbReference type="GeneID" id="110983390"/>
    <dbReference type="KEGG" id="aplc:110983390"/>
    <dbReference type="OMA" id="RFGHQRY"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000225">
        <property type="entry name" value="NK3 homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF73">
        <property type="entry name" value="HOMEOBOX PROTEIN BAGPIPE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="194"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="196"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="141"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098314.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37525" checksum="464F4B4F77B54D2F" modified="2022-01-19" version="1">MVGSTASRVNGSLTPFTILDILGRRSSDNSQTSAVDSPEDKLPVPKLRERRATSAERSEGLRMRTVPVPERLDALYPASTVRQAEQMSREHLAHQRRPHHQQQLQIPREELARCRYTDRVFIEREEGLEHDPVLFSRHHRHLAEKSSRGEENQRPESRLVETDDRVIAEKLEEEDEKSHQSPAPASSAGSQKEGRKKRSRAAFSHAQVFELERRFGHQRYLSGPERADLAAALKLTEQQVKIWFQNRRYKTKRKQMAADMMSSLPAKKVAVKVLFRDPHGQPPLYPESSLPLPTSPVTYHGLLGQFGCHAYPPMCSHSHYPLNGLLFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYF5</accession>
    <name>A0A8B7YYF5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110982994 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982994</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097520.1">
        <property type="nucleotide sequence ID" value="XM_022241828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYF5"/>
    <dbReference type="GeneID" id="110982994"/>
    <dbReference type="KEGG" id="aplc:110982994"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="7">
        <location>
            <begin position="318"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097520.1"/>
        </source>
    </evidence>
    <sequence length="577" mass="64731" checksum="F5D6E40CFF6E5AA8" modified="2022-01-19" version="1">MVTMATRKQLSSVTQRLFTNHLECDICHCPYQDPKTLCCLHSFCMDCLMRYRDARKTRKLHCPVCQQLTQLPSVGVRGLPDSITLMHLAEDMEWIGEQNKDSMNKPTCPKHKAKVMRFYCDTCRMLICRDCIVLDHPRENHQILDTKADRTGYKQALVHHFPDYEKTLASITNDHDRIVEAKRELRDRVDAAIKDVTTRTAEVMCTPEVRAEEEKIIGEICTLEECQKSKLSRLARVGERRKLSRQVLETGRDDATAYDYDFLALYDVIIMGMEMLSGCSPPRAEGVRSYPAFAHSWKVEAPLGKVVMEDTWELCCAFGKRGSGPGEFESVRGIAAAEPNEIAVADWRNAQVLIFNNKGHIKDSILILANDIVSTKDQWVILSTSFVKVYNRGNKQLADEFQTRQQGDEVGKVYEAPLSLAIRTDGNIIVGYRGRGTLTEHSPTSGDLVRTIPVQISPSFLAVMSNNWLVISDHVKGLVEVVEVADDKAVTLFTIRPTISGERVKSCRGVCSNDSGIYLGVSTGFHNGGHVHHYDNEGDFISCIAQGLYGPYGITFTADGQELAVADHHSVKIYHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYQ4</accession>
    <name>A0A8B7YYQ4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110983487</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022098468.1">
        <property type="nucleotide sequence ID" value="XM_022242776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYQ4"/>
    <dbReference type="GeneID" id="110983487"/>
    <dbReference type="KEGG" id="aplc:110983487"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14276">
        <property type="entry name" value="UBA_UBP25_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054108">
        <property type="entry name" value="USP25/28_UIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21909">
        <property type="entry name" value="USP_UIM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022098468.1"/>
        </source>
    </evidence>
    <sequence length="165" mass="18108" checksum="416DCD938EFBA61F" modified="2022-01-19" version="1">MSLLVDKTASSGEPEVYYSRYMRRRQLNQEIALNQLKEITGVQDVLTLKHAYEASGGDIGQAVTFLTDHNAEHPTRQPALPTPASKSVPKNQQVTTADSETSTDAVPVQSPKNRGQDVIDLTHDRDEKDDLQRAIALSLRETTGPSATIGVSTEEQDISRLKPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0H7</accession>
    <name>A0A8B7Z0H7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">2'-5'-oligoadenylate synthase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110982655</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-5A synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096925.1">
        <property type="nucleotide sequence ID" value="XM_022241233.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096926.1">
        <property type="nucleotide sequence ID" value="XM_022241234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0H7"/>
    <dbReference type="GeneID" id="110982655"/>
    <dbReference type="KEGG" id="aplc:110982655"/>
    <dbReference type="OMA" id="TFNVCEN"/>
    <dbReference type="OrthoDB" id="9978031at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001730">
        <property type="term" value="F:2'-5'-oligoadenylate synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.20">
        <property type="entry name" value="2'-5'-oligoadenylate synthetase 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018952">
        <property type="entry name" value="2-5-oligoAdlate_synth_1_dom2/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258">
        <property type="entry name" value="2-5 OLIGOADENYLATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258:SF11">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10421">
        <property type="entry name" value="OAS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2'-5'-oligoadenylate synthetase 1" evidence="2">
        <location>
            <begin position="191"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022096926.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39146" checksum="12305F9499834799" modified="2022-01-19" version="1">MMATASAKTKVGLPWCTAMSPRELETWYNENIQHGTDDFDRDCRRAVDEVVRSVHRICSSNGVLFDVDRVIKGGSLGKGTMVKDLSDVDLIAFINPPHLKPIVTLGPTHYRKQLEGVIRDLEGALRQLSFVKNISRNDFLVNFTIGNLGPTKRSLGVDLLPTADNCLGHGRAHSDMFRAMLQLPNGYDREFYSASLAEHQLKFVAEKPGYVKALIRLVKYWAYECLPEKLQTSYPLELITIYRWENAGKPVHFSKAQGLKDVLQVLTNLRGLRHFWTYLYDASLANQAIKQLDYVNPIVLDPANPNNNACWVYQKRGNNVREVEDSARATLKCALLKDVVVTPNWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z307</accession>
    <name>A0A8B7Z307_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110984292</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022100009.1">
        <property type="nucleotide sequence ID" value="XM_022244317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z307"/>
    <dbReference type="GeneID" id="110984292"/>
    <dbReference type="KEGG" id="aplc:110984292"/>
    <dbReference type="OMA" id="WGNDEDC"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000128">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034820852" description="Carboxylic ester hydrolase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="8">
        <location>
            <begin position="25"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022100009.1"/>
        </source>
    </evidence>
    <sequence length="601" mass="65321" checksum="ADCFBCB784980D44" modified="2022-01-19" version="1">MMHVNSLCVLYLFVFLTGASSNETPPVVTTSQGRIIGKTVEFSPIDPALRRSVDAYLGIPYAEAPVGPLRFKPPVAKLWSGELQATKLGNSCPQPLLLFGNVTMSGNLDENCLFLDVFVPKPVPPEAAVLVHIHGGGYMAGAGTMEELLWPTPTAAIGDVIVVGLNYRLGALGFLSTGDDIISGNMGLLDQRLALQWVRDNIRAFGGNPERVAIFGASAGGSSVGLHMVSPGSAGLFRGTILQSGDAAAPWATMSPSTARRQAFVLGKLVGCDSQSSEELLECLLKVDGFDSFLENQGHQDLQEETGMMTFTPVIDGEVIPASPDDLYAKGAINDAVSIIGALADEGTIMVALSFPNHTHEAPFVDGDTFERLVKYSLDLMNGYKPIVLEAVKMMYTNASCRDASNCDYLQSLSQVIGDVMFVCSGRKTAKAFTKAGRTVYHYQMTHTATTTLMGRKWTKAAHGDDYMFVFGMPLIPSSNWSFSEDEARMSEQIIKYWANLAKTGNPNLSSLDGEQREEEKLPEWPLFTLEELTYKDLSLSMGNGRGIKAKECLMWNEFIPKLVKIADEAKNCQGANDVRETENDRDEEQGVCTKETCPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3I5</accession>
    <name>A0A8B7Z3I5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">ADP-ribosylation factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110983187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097926.1">
        <property type="nucleotide sequence ID" value="XM_022242234.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097927.1">
        <property type="nucleotide sequence ID" value="XM_022242235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3I5"/>
    <dbReference type="GeneID" id="110983187"/>
    <dbReference type="KEGG" id="aplc:110983187"/>
    <dbReference type="OMA" id="HYFCETH"/>
    <dbReference type="OrthoDB" id="9986014at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000412">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022097926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022097927.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24112" checksum="02B883DB480E9F18" modified="2022-01-19" version="1">MGAKSTKMGHVMGKLSDFLHVDCRFSMSGDKESRILILGLDAAGKTTILYRVKLGEAVTTIPTIGFNVETVTPVPNVTLCVWDVGGQQKVRALWQHYFCETHGLIFVVDSADRGRLWEARDELFRVVNNPHMTKRIPVLVLANKQDLPGAYNAARVSEVMDLQALSENHPWQVIETQASTGEGLHEAFKTMARMVKQFHKDSSKADIASSKSGDATEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3P7</accession>
    <name>A0A8B7Z3P7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110983966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099405.1">
        <property type="nucleotide sequence ID" value="XM_022243713.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983966"/>
    <dbReference type="KEGG" id="aplc:110983966"/>
    <dbReference type="OrthoDB" id="18982at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026849">
        <property type="entry name" value="ATG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13190:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13329">
        <property type="entry name" value="ATG2_CAD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="575"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1652"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1840"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1883"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2184"/>
            <end position="2207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="581"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1676"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1842"/>
            <end position="1853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2189"/>
            <end position="2207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022099405.1"/>
        </source>
    </evidence>
    <sequence length="2207" mass="244559" checksum="B6D2EB95DD542EEB" modified="2022-01-19" version="1">MPWYFPWPDYIKKKACRYLLQHYVGSFQEEKLTLDQLSVDLYSGTGTVKDVKLDVWALNELLESVAAPVEMRDGTVGSISVEIPWSALLTANSKVEIKGLKLTFQPKYRLNTEASGSATSSMMDSMWTSMSMTSSMQLAQECLKRDSSETDPDLASPSSSSSSSSSQPFEGPELLAQMIESVLTRVEMTLIDTIIRLEHVPQGCQSGIALELHIERLRFFDEGAHSGPQDQGSSVDASRVPHFQPAAVAHKNFQMMGVTVHCEEFPEDQRHTVVRAPSVDVHRRDPPDAFPSLAHSPEMPPQHTQIDQGGDGAGEDLRVGGGSGRGGGLELLGSCIVGECAGKQEVKVRVKQHEHIAGPKAEVETYLGSINLFLSPRQVHLLLELFSGFLSPATSDVTSTRGSQPNKPMQPEDFQRIESELQEQLSRDRLQRQEERLRRESWGLKEDEEEQGCGDMFTMQSLMDDDDLFFSMTGSLMSMSHTGTLDDMETSFTSTVSSSSTDTSRTGSSLPRVVYGNTIYRGPSLTSFGTPVPKTTQPKRSRSKKGLREQLDDPTAELTRYKLRFSSLSLTVLHNDPARTPLNNTSPAGGSRTAQGADRGRASGQDALQERSEDFFRVLGKQGYGKKDQGEWKERFARACPYDHLRLTAAPVTLDCDRKSAPNVTAVTADLSFGLLELYECLFDRPRNSSSGSFGHGRFADDLPSCQHIEVLSFKEEDSVANEYVAVKPSLGIRLKSIQRSSSQGSQRRIIHKPKSEVSVDLGHLSCEFDVTIVDRLYTLLHPQSVGLAKASVGNGAYRSLYGGVVNLNKQAVFNQALEDTPSGLDQFLDIRVSCPVAHVAFRFPIPDLRELSDCVWWKRSLREEILHLELQEMEFRTMLGDGKPYQTLLLQCRELQSSLQIGPLESPISFLRVKDGNGDINSTDRDFDWPKLVVKLYPESEKSVFEDVGDRSASPPVNSWEGACHFEKPEVSPFSSKWVMYDSEKMVMPGDQEEMREFSEKAIGSARIVVDLVAPSVNILLPSKDFVELLYNRFGYDVLLWQPAAPTPRDCNDGYPSVGLPRLDLAGHLAGMSMQERFTMCQSGLYVDSDSDPEEDSSGFYTTLRQKSAHQVQSGNSQSFLALNLTINHGKLTMCTPLKESPFHGDTMLEIEDGSLFTVTDYKGCANLSYLCLQANRIALYHNGRVDSPLQTGPLPHATWAPPDHLQCCIYLSDGGVPSKLGGSVGNGAGSSNMVALAMKMFFNTETNIKNIECAVGVRGATLRHYMSKPEHSWLVQLSDFFDVVDEEVLGYDMPSVVTEFHAHFWGCGIDYRPLNLPLRTYVMAETLSISSNLVYEAKESLLRFLVDDAAVFLSDRCNERSVDIRNNYVCVLDLGMLEVALRMSTVKDKNPKIDLKVSNNIVHLRTCADSCTALARLILYLASDGDHSPPQHSPAQQQWGDHQKLPTEQTDVDDEEPFVINGQPVSDSPIGRGNHLDQMQQLMDEAMRDVRSGMSPPPGEGSPINIACTLKRDGDLFLFPNEDQANEEDAVLEASPHHHRSLNGLPQPVSGHFEMTAEDEAEDGFFNDEEFCVLDDPGMGVLRTQGEPEVQCLEDTPIAIQEDHFARPLGRGDQLNAPAHFPTAVMKYTLQEMTVVWHIYGGNDFGPASPRKLSVPDVPSSSPARPSTPDRSRTMPSNTSSPASRKTKERQQQLSWYERGGPGRDHSTLMELQMNKVRFQHSQYPDEAQQRSRQILLISDIEVRDRLANSQINKFMYLYSSEARPRRTHANMVLVKALHIRPDPNLAAEECCLRISLQPLRLNVDQDSLFFLHDFFNKVSADAGRVPIPETKEHLHHYATSPTKAHTTSVATPVDTPISRPQSLSPASIEHWLADGMEEEDEDLYDGRGFEGNSLGGSDQTDPEHEPLSEAHNAPSLVATETNAQGAGAPIFFRSFVFSPDVPIKLDYEGKRVDMEQGTLMGLLMGLGQLNHSELTLKRLHNRHGLLGIDKLILYAINEWANDIKKTQLPSLLGGVGPMHSLVQLVQGMVDLVRLPVEQYRKDGRLMRGFQRGASSFGTSTAMAAVELTNRMVRLLQAAAETAYDMVSPGPSVSSRAITYGPFGQSRLARQPADFREGMANAFNVVREGLEDAALAMVQAAREEHQHKGVSGAVGGILRQIPPTVIKPLILASEATSSVLGGVRNQMRPDARKEDSEKWRSERNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4H6</accession>
    <name>A0A8B7Z4H6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17 18 19">High-affinity choline transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">LOC110983358</name>
    </gene>
    <organism evidence="16 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098249.1">
        <property type="nucleotide sequence ID" value="XM_022242557.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098250.1">
        <property type="nucleotide sequence ID" value="XM_022242558.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098251.1">
        <property type="nucleotide sequence ID" value="XM_022242559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4H6"/>
    <dbReference type="GeneID" id="110983358"/>
    <dbReference type="KEGG" id="aplc:110983358"/>
    <dbReference type="OMA" id="KGDTWVW"/>
    <dbReference type="OrthoDB" id="546820at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005307">
        <property type="term" value="F:choline:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11474">
        <property type="entry name" value="SLC5sbd_CHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000008">
        <property type="entry name" value="High affinity choline transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052244">
        <property type="entry name" value="Choline_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45897:SF4">
        <property type="entry name" value="HIGH-AFFINITY CHOLINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022098249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022098250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022098251.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="64119" checksum="7D264EACABBDAD14" modified="2022-01-19" version="1">MAVHWGGVIAIIVFYLLILGVGLWAARKSKGKNDSEDVMLAGRNIGLFVGIFTMTATWVGGGYINGTAEYVFRPDYGLLWTQAPWGYAASLILGGLLFAKAMRSQGYITMLDPFQLKYGSRMGGLLFIPALTGELFWTAAILNALGATISVVLELPMSISVIVSACIAVFYTFFGGLYSVAYTDVVQLICIFIGLWICIPFALTNEAVEPIGLTSTRWLGTWDPSFAGVWVDSALLLIFGGIPWQVYFQRVLSSKTAERAQALSFVAAIGCILMAIPSILIGAIGASTSWNATTLNLEVTDPYNQTSLLLPLVIQYLTPQVVSFIGLGAVSAAVMSSADSSILSASSMFTRNIYKLVFRQKAGEIELLWVMRIGIIAVGIVATILGLIITSVYDLWFLCSDFVYVVLFPQLFCVVYFSKCNTYGSFLGYIIALILRLGGGDGVLGIPPFIKYPYYSAESGQLFPFKTLAMLVSLLTVVLVSYLLDWLFRSETVPKRFDVFRCVVNLPAGEDQEKYDNVDGEKLQLRKLDPMGLPAAEGTTSVTPLQREKLLDITRGIMPESASMEPLKEDEASSPSDEDRPLADQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5P0</accession>
    <name>A0A8B7Z5P0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein trapped in endoderm-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110984776</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100954.1">
        <property type="nucleotide sequence ID" value="XM_022245262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5P0"/>
    <dbReference type="GeneID" id="110984776"/>
    <dbReference type="KEGG" id="aplc:110984776"/>
    <dbReference type="OMA" id="RCIHITK"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="51"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022100954.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="41128" checksum="33FE4C29BE383343" modified="2022-01-19" version="1">MAVASVNETSSIVDIVSTEEPATASPSLYPYQARIGFSCCWIIVAILGVVGNSLVILSVILSKKLRTVTNAFVVNLSVADFWTSLSCPWQAVALLSRGAWPLASEVPCKIAAMQLSTGYGTSLYSLAAIAFNRFILITQTTATYSRWYSPGKVSSIIAMTWVIPAVVSFLPPILGIGDLGYDAQDYSCLDKDGHPRAAEYNLAQSLGMYPIPLLIIVGSYLALYIHLKRHFRKRKRRLNQYASPAQGDAAAVAESTVSFAIETESSRCPTTDIAKSNRRAISRQQLAITRNLFMVFCVFVLLVSPFFLAIAVPSSRKFTLYGAAIAIFNSCVNPIIYTVNHPQFKGVLRSILRCRYSQIPEPSDWLKSVLSWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z821</accession>
    <name>A0A8B7Z821_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Alpha-1B adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110984769</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100945.1">
        <property type="nucleotide sequence ID" value="XM_022245253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z821"/>
    <dbReference type="GeneID" id="110984769"/>
    <dbReference type="KEGG" id="aplc:110984769"/>
    <dbReference type="OMA" id="MASMHET"/>
    <dbReference type="OrthoDB" id="10039923at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="50"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022100945.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="41169" checksum="C9345245C0563470" modified="2022-01-19" version="1">MASMHETSTSLLESNTTAEPSTSSPPLYSHQARIGFGCCWIIVAILGLVGNSLVILSVILSKKLRTVTNAFVVNLSVADFWTSLSYPWQAVAILSPGEWPLATEVPCYIAAVQFYTGLGASLYSLAAIAFNRFMLVTKTTETYSRQYSPGKVSVIIATTWVIPTVVFFLPPILGIGAFGYDPQDNTCSDKDGHPRGSEYNLAQSLGLYPIPMLIIVSSYLALYIHLKRHFRKQKRRHMLQESPPLQSDDSVVAESTVSAIVVTASHKNEMVRNQRQAINRQQLAVTKNLFMVFCIFFLLMSPYFISLAVPSSGGFALYGATFSILNSCVNPIIYTANHPHFKGVLRIILRCRFSRIPEPSDWLKSVLSRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB24</accession>
    <name>A0A8B7ZB24_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Urocanate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110984496</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-imidazolone-5-propanoate = trans-urocanate + H2O</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the urocanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022100441.1">
        <property type="nucleotide sequence ID" value="XM_022244749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZB24"/>
    <dbReference type="GeneID" id="110984496"/>
    <dbReference type="KEGG" id="aplc:110984496"/>
    <dbReference type="CTD" id="131669"/>
    <dbReference type="OMA" id="VHFQGLP"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:L-histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1770.10:FF:000002">
        <property type="entry name" value="Urocanate hydratase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1770.10:FF:000003">
        <property type="entry name" value="Urocanate hydratase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10730:FF:000002">
        <property type="entry name" value="Urocanate hydratase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="entry name" value="Urocanase like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1770.10">
        <property type="entry name" value="Urocanase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055351">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003820">
        <property type="entry name" value="PRK05414.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216:SF3">
        <property type="entry name" value="UROCANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase N-terminal" evidence="12">
        <location>
            <begin position="85"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase Rossmann-like" evidence="11">
        <location>
            <begin position="214"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase C-terminal" evidence="13">
        <location>
            <begin position="441"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022100441.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="75067" checksum="C0696C1CFC1E35E1" modified="2022-01-19" version="1">MASLKEMCEGLPLDPLPSARTRDNNIAHAPVRVPNLTPDEERLALQNALRYFPPELHDVLAPEFAEELREFGHIYMYRFRPNIEMRAYPINDYPCNTRQAAGIMHMIMNNLDPRVAQFPHELVTYGGNGQVFSNWAQFRLAMHYLSEMTEDQTLALYSGHPMGLFPSHIDAPRVVVTNGMMVPNYSSRENYDRLFGLGVTMYGQMTAGSFCYIGPQGIVHGTTITVMNAGRQQLGTSDLRGRVFVSSGLGGMSGAQAKAAVICGCIGVIAEVSKEALLKRHKQGWVMEVVDSLDVCIERIKRAKKEKTPLSIGYHGNIVDIWERMVTEYDSTGELLVDLGSDQTSCHNPFNGGYYPTQVSFDEANDIMTTDPVRFKNLVQESLRRQIAAINKLADRGMYFFDYGNAFLLEASRAGADVKKEGDQTGNRFRYPSYVQDIMGDIFSLGFGPFRWVCTSSDPNDLATTDEIATTVLEDFIRQGVPETTKQQYEDNIRWIKEAAKHKLVVGSQARILYSNQRGRMAIASAFNQAVSEGKLRGPVIISRDHHDVSGTDSPFRETSNIYDGSAFCADMAVQNVIGDSFRGATWVALHNGGGVGWGEVINGGFGLMLDGTERAGERAKAMLAWDVTNGVARRSWSGNTKAQETICHAMQSNSKLKVTLPHNVQSDVLDRAFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB26</accession>
    <name>A0A8B7ZB26_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/arginine repetitive matrix protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102182.1">
        <property type="nucleotide sequence ID" value="XM_022246490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZB26"/>
    <dbReference type="GeneID" id="110985454"/>
    <dbReference type="KEGG" id="aplc:110985454"/>
    <dbReference type="OrthoDB" id="5985669at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF9">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="682"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="724"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102182.1"/>
        </source>
    </evidence>
    <sequence length="853" mass="92771" checksum="B8D6035566CB2275" modified="2022-01-19" version="1">MRLYYPEGNDLKVKIERSLSVPRARDDSDIKSDDDAEAPHPGHRFFTPQPDRKKPLLLPKPRASIPAVSPKIREGDEKHNDKESSPKAKTHDDTKEVEDRENDSVPNGHLPANEGTGARKTARLTALRAASTMEPLIPKRKAPSQPPLSKRRTSDTQLQVIEQLMKRNEALKHSGSSTLKPGFGKKVARSASSAGLLSPSSSHERHRGSRHQFLTPQPTRRKFNLVDRTPSFNDGSPVGPVARLALKNKRLTSHNSSDSAHSPDLSPSPSPHTPVSPLAAPAYKTKKMASQHSSDSGLTTESSPSPTPHTPVSPLAAPAFKIKKLNSQQSSDSGLSSDLSSSPSPLTPVSPLAAPAFSGRMRQTVRPAPAIPEGQQNKIDFHQWKGPDKEKQWTKPEKSNTGSKDGISRNRPISMPNNIRRVSRGSVNKSKQRQSAVRQVAARQLASTVRPPVSSPAIGRSNSSRQRHQSAPAGRVALALKHDPTTPVTSLTGGESQLNTAISKGIRRRHASDSLRKEVLRSVSIEKSRKMSLMSDDGRSKEEVTPLGKADFDFRQEMVRMKSGHDQPDASTQALNGSAKSSMKRFVSADNRSVYSDYPSTFSDSPGGSPTRQRPKLRRGRSSRTSLGSLKSMLASNEFLNDIFLSDRKSHRKLKGIVGALAGLVLGGFLFLGLYYGLEYSLVASIVMTSIATIIMSMTLAFTVRARCVAALMIPTLCTSRGRAAFLALIVTLLLTGPIDNIYTNAKVASDSMSCSAELAQNQTVLIRDAAREIFDVYIRTLEDSVRKLQDAAAAVQDAFEPVENALNDFVEALGEAKEAVRVAASHCKQIINGAYKIALKELTLQIEIVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC82</accession>
    <name>A0A8B7ZC82_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110986022</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110986022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103294.1">
        <property type="nucleotide sequence ID" value="XM_022247602.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986022"/>
    <dbReference type="KEGG" id="aplc:110986022"/>
    <dbReference type="OMA" id="LFTYPWG"/>
    <dbReference type="OrthoDB" id="6107827at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="entry name" value="Glucose Permease (Domain IIA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.230.10">
        <property type="entry name" value="Lipovitellin, beta-sheet shell regions, chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.20">
        <property type="entry name" value="Vitellinogen, superhelical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015819">
        <property type="entry name" value="Lipid_transp_b-sht_shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011030">
        <property type="entry name" value="Lipovitellin_superhlx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015816">
        <property type="entry name" value="Vitellinogen_b-sht_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001747">
        <property type="entry name" value="Vitellogenin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01347">
        <property type="entry name" value="Vitellogenin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00638">
        <property type="entry name" value="LPD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56968">
        <property type="entry name" value="Lipovitellin-phosvitin complex, beta-sheet shell regions"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48431">
        <property type="entry name" value="Lipovitellin-phosvitin complex, superhelical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51211">
        <property type="entry name" value="VITELLOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Vitellogenin" evidence="6">
        <location>
            <begin position="40"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="4">
        <location>
            <begin position="1335"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="5247"/>
            <end position="5350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1216"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3591"/>
            <end position="3624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1220"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022103294.1"/>
        </source>
    </evidence>
    <sequence length="5944" mass="655340" checksum="F38F52DB16597730" modified="2022-01-19" version="1">[encoded data, 5944 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCG4</accession>
    <name>A0A8B7ZCG4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cytochrome P450 2J2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110985741</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102672.1">
        <property type="nucleotide sequence ID" value="XM_022246980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCG4"/>
    <dbReference type="GeneID" id="110985741"/>
    <dbReference type="KEGG" id="aplc:110985741"/>
    <dbReference type="OMA" id="GVPGRIW"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF417">
        <property type="entry name" value="CYTOCHROME P450 508B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022102672.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="60052" checksum="99889CCBF56519EB" modified="2022-01-19" version="1">MKIYTSNKMDSVDHLIFVIFDSCSLGSGFLYAITFFSVLWLFLRWRTAKPNFARGPSFLMSHLLLLKAALTRRSAPQLLFTDIAKTYGPIYSLWIGFNFVTVVTDLELSREALIRNPDSFAHRRNAAVLERIFQKGGGIISESGNPWKERRRFGMNAMRIFGAGKRRLEPRINEEANFLAQSFADHCGQPFDPIPLVINAVSNIVAQISLGQRFEYTDTSFQAVVRIMRDLTEVGILEVGNVFPALADTFLYQRKRSDFRQLKGFIEEQVRIHRATLKANDPRDLIDLYLQEADKESTDFSEKDLDSEPVFTESNVWRFIQDIFFAGTETTALSLLWILHLVTMHPEIQEKVQVEIDDVIGRARQPTTSDMVSMPYTQATILEVIRHRPVIPVYHRESPPDGNGKFAQYTVPRNSYFLINVYGMNHDPKVFPDPDMIRPERFLTVDKNGKRIFSGKGQLLMNFGSGKRACVGESMARTELFLFVVNLFQRFTFTFSAEDGPPNLEGVPGRIWSPLPFRLCAETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCV3</accession>
    <name>A0A8B7ZCV3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MMS22-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methyl methanesulfonate-sensitivity protein 22-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110986161</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MMS22 family. MMS22L subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103503.1">
        <property type="nucleotide sequence ID" value="XM_022247811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCV3"/>
    <dbReference type="GeneID" id="110986161"/>
    <dbReference type="KEGG" id="aplc:110986161"/>
    <dbReference type="CTD" id="253714"/>
    <dbReference type="OMA" id="RVYLCLL"/>
    <dbReference type="OrthoDB" id="8193282at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042320">
        <property type="entry name" value="MMS22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029424">
        <property type="entry name" value="MMS22L_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029425">
        <property type="entry name" value="MMS22L_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28547">
        <property type="entry name" value="PROTEIN MMS22-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28547:SF1">
        <property type="entry name" value="PROTEIN MMS22-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14911">
        <property type="entry name" value="MMS22L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14910">
        <property type="entry name" value="MMS22L_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein MMS22-like N-terminal" evidence="12">
        <location>
            <begin position="57"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="MMS22-like C-terminal" evidence="13">
        <location>
            <begin position="831"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022103503.1"/>
        </source>
    </evidence>
    <sequence length="1237" mass="139086" checksum="3F2D05F83C1C6524" modified="2022-01-19" version="1">MDLDLEYSITPPLSPCDVASGEDSPPSLGQSLKQDSVQCLACVECFNIREHHTSLTSTLKRILLGKDPNPECFQDNTCELFGHTYVTGVALLDATSHLFCLSRQCVTKIQSLLGQGSSWGLIDPLVSEAKRLHGHVMTFMKYVQAFIYRYFNLPDATLPPSVYTQRLAVFPSLLVTELQTLSMFNGRISELPVGVLQQCAASSTRQDSTGSLLLHMNLSTQWSIVQVLHLLQAKLKGEQDVLSSFNEKAVEFFQDLLNIATLKYNKIGYSDHHQHGSFPDGCLQDLWSSLIHLLDSRHNQYSTDSFWCSFHSCLLPLLDEPYNPSREATISSDPPPYPKPRDPVGLCWWLLQYVAPLCQYDPNGQLVMSKQGRPVRSYWLLVEDLLKIMFTSNEAVPDEARMQTYLRSCLVLCHLWEPKGSVLTLLWGHFHKRLNKKLIVPGEGVKNLASICQTPHSWYDHCKERIADHTASRHHENSFDLFLHILATQLKGMKELGGSQGWKQLQGRFYSKFHSRSMKELDETGLSRFLSLFLTFALVTDLSDVTSRMLDFLDLLPTDTLTHGKLLLIWRGLFTFCLVHEDQSCDLAVVADRLVQGFNTVSVEMCSKSVDSGRKSQLWALVLSYMEATQEVFDASNKLHLSEEKLIGSGLSNLLEVSSEHEMRALLTFLQTIMARHRSLYQQVLMQRPYLAVTSVASPAPEMLMHKYKALAKILWDLVYPFIKRHASTQTPPSELADVATSFTLLAADLKLHDEASGLSQPTSQELFHFYGLDDHKVHYSITVRYLCHLLPNHSFTEQLQAAMGHTRWASSLIHTWLRCGLQSPQAGTSMQELTRLVFKLEEASTIMDSQSSNSLIDGTGNPHKHVMLQFIQALGHQFNSARGLQERVQKRQTILSYFGDLVELIQPMLRNLRSASDLSWIYKVVGHIIKCCSSILYVKGKSQAQLPGILTELILPPALFNPKKGLPSHMLSAIRETLHLFLEGLASLDLQRNEFIQRKIQEIVQQYFHRFQVKNSSLAAGSLGSSSANHPLMVALHKSCARLPNPQISALRELVLKVICQQYLIYHGQQPPSHLPYTLAFLQELLHRTSSPQQIVRDTVVLLGVVLDYLLLCDVNTVKKSMMVLLTAMMDACRRDMPPNLQADLLSVLRGYLSKHLRVHQAAVLLTLETVAVQHPALVTALIGDCSRLVSECEHKRGVGADSTLRQAYCSVLSHLGEAGEAVISKIKGGEELVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZD81</accession>
    <name>A0A8B7ZD81_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Zinc finger protein ZXDC-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110985844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102927.1">
        <property type="nucleotide sequence ID" value="XM_022247235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZD81"/>
    <dbReference type="GeneID" id="110985844"/>
    <dbReference type="KEGG" id="aplc:110985844"/>
    <dbReference type="OMA" id="PERRIKC"/>
    <dbReference type="OrthoDB" id="6277246at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000007">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEA6</accession>
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        <name evidence="2" type="primary">LOC110986434</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
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            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_022248282.1"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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            <dbReference type="Proteomes" id="UP000694845"/>
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        <source>
            <dbReference type="RefSeq" id="XP_022103974.1"/>
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    <sequence length="293" mass="33966" checksum="46322561A73E2ECD" modified="2022-01-19" version="1">MEHYLPSLFHGDAKYYLQSLHAFRAACIKYPEYDQWEETIFQQTVVSKLKSALDEQGELRVMGVGSGSGERECKMLIKLLQHFPRINIRAVEPLQEQLVKYQALTKSKTSDLRGVNFEWRQQTIEEYEKVEEPTKFHFIVAVHSVYYFDNLEDSLMYLHSILEPGGVIFIDMKSDDSGLVRYWNHFAPYFHSKYNFITSADVRSILDRHGIPYSQHHEWSRVNITSCFDDASEEGSMVLDFLNHVTRFKESAAKDLKQQVLEYLASSACSEKSGDEILLINDCDTIIISKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEI1</accession>
    <name>A0A8B7ZEI1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="10">HMG-CoA synthase</shortName>
            <ecNumber evidence="3 10">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
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        <name evidence="15" type="primary">LOC110985133</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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    </organism>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10189"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="3 10"/>
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        <property type="nucleotide sequence ID" value="XM_022245929.1"/>
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    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00102"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="12">
        <location>
            <begin position="15"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="13">
        <location>
            <begin position="189"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="472"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022101621.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="56536" checksum="8304173CA0A7AA5C" modified="2022-01-19" version="1">MPSPSDMSKNADGRWPDNVGIIAAEIYFPSQYVDQTQLEVFDGIPAGKYTVGLGQAKMGFCTDREDINSLCLTVVQNLMERNQVSYEEVGRMEVGTETIIDKSKSVKTVLMQLFRDSGNTSVEGIDTTNACYGGTAALFNALAWVESSAWDGRYALVVAGDIAVYATGNARPTGGAGAIAMLVGPNAPLVVERGLRHTHMEHVYDFYKPDMASEYPRVDGKLSIQCYLGALDKCYKGYCAKAEALMQKEGDASRCSLDKFDAVCFHSPFCKLVQKSLARLVLNDFLRDPNPSTEEGGRYAGLNGYKDLKLEETFMDRDVEKAFMTCSKDIFAAKTKPSLLIANQVGNMYTPSLYGGLISCLASLPLEELPGKRIGLFSYGSGLAASLFSVRICGDTAPGSPLWKLRASLDDLRFRLDSRKCVEPAVFADAMQLRENTHHLAKYAPVGSVDDLFPGTWYLTYVDEMHRRKYSRKPLSDLPSPRVDSAPVSSPIDTLKSAVTPQKRMEEANSSTAVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIE7</accession>
    <name>A0A8B7ZIE7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neuronal membrane glycoprotein M6-b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103041.1">
        <property type="nucleotide sequence ID" value="XM_022247349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIE7"/>
    <dbReference type="GeneID" id="110985901"/>
    <dbReference type="KEGG" id="aplc:110985901"/>
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    <dbReference type="OrthoDB" id="9993736at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF12">
        <property type="entry name" value="M6, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022103041.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44495" checksum="597F099ACA8F3205" modified="2022-01-19" version="1">MDHESDVTKNEVTVDYYSRLPGPCGDCCLKFPCPSVIACAMMIVGDILLLAGFHLGAEEAKYLFAGTPITEAFNVWFTDVQIIIYCVSVFMFIIAIVLLAISCLGTGSTRSVYLCRFKTRRSGRCQTAVFILIAYFLVFCWVTAICFAVVPVFFMFVMNRGVCLGVEMEQQTCLNLVQWALLSPDTPVGLGKELVCDDKMRNICQSNMMLLFSLAFLGCLLILLASVQFVVSMSANFAQLLDRYKRAYMSDTAGSYNMRSGVRNIMRGSKRNDTGHTRAGARTNVALTRYGAGNGAYTGNGKSEESEADQRYSSLEMTSFRRQEEPPPPNPPPYIPSTREPLSNLQHRARSYDPLDYNDYNTGQLNTSRVKNMSRSAEPIDFGGQYDRYDRYNEYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZL00</accession>
    <name>A0A8B7ZL00_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic cation transporter protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110987605</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
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            <taxon>Valvatacea</taxon>
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            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106159.1">
        <property type="nucleotide sequence ID" value="XM_022250467.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110987605"/>
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    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="88"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022106159.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42219" checksum="2B78EC118AED53E6" modified="2022-01-19" version="1">MQFDNILTHIGAFGRYQKIICPLLGLVGITFAFHAIAQVFLAAETDHWCAVTADQSLNCTGLDLETAVECLNQQKELTIPFTVDKEGQVVYSKCERYVEAWDGELERNGTNGTLQRDEASNETIPCDRGWEYDRSQYHSTIIQDFDLVCSRGDLPGLAQSVYFGGFLTGSFVWGAVADWVGRRFTIFTSLSVACLTSTLLILVPTLAAYSALRFFIAAAVFGVYLVTFVLVSELVGPAYRSLAGTLFSIYFSIGYTLLAICAYFLRDWRHLQLAISLPSFLFFSFLSFLPESPRWLISKRKFKQAEKVIRKIAKVNGSSVPANLFSETDELQEKTVLTRQATQIDLFRTPNMRKKTLNIFYQCLIWYAPEGIYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM12</accession>
    <name>A0A8B7ZM12_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cationic amino acid transporter 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110987575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106102.1">
        <property type="nucleotide sequence ID" value="XM_022250410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM12"/>
    <dbReference type="GeneID" id="110987575"/>
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    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097638">
        <property type="term" value="P:L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF105">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="503"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022106102.1"/>
        </source>
    </evidence>
    <sequence length="611" mass="66470" checksum="D7215DC46F1230CB" modified="2022-01-19" version="1">MTVTHVSTTANTPTRHTRVEPARKHSPQCQIHWSRRPYYQTGGSQFGSVPNSMVLCTIMRALTRRKNINEEALRESHFQKYLSTLDLILLGVGNTLGAGVYVVTGVLGKFTAGPAMIFSFLIAAVVATLSVALGFGAKMSSSVNNIFAALNLFVIIYVIVCGMFRLDTSYWHIPAVELPKGPCKAQPDNQTSPPQCENYGSGGFMPYGFSGVMVGAAMGFYGFIGFDVISTAAEEAHNPQKSIPLSTMATVFFVFLSFFGVSIVLTMICPYYLLDEKAPLPEAFERIGWTVAKYVVTVGGIVGLFTSLVGCIFTLPRYIYSMASDGLLFGCLATVNKRFNMPVNACIFCGAVAGIMGMLLDIGSLVSIVAVGTLVPYALVAACVLTLRYEPDFSSIAAATHLYPTVGEGERATFVDSLLAILKQAMWPRYAEATLLSSRVVTIAVFLLTLSFIGISSVIEFASDCLMRREPWVLTVTSLISVLIVLLLITIARQHQSNTEISFKVPMVPVVPAASLFINIYLLVQIDSLTWARYLTCMFVGVVIYFGYGVWNSKECSVDPATRRHKKIVASAKKIAKETEMEQSGKSCRMAENDASGTHTLLSAFDMSPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM98</accession>
    <name>A0A8B7ZM98_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Juvenile hormone acid O-methyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106743.1">
        <property type="nucleotide sequence ID" value="XM_022251051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM98"/>
    <dbReference type="GeneID" id="110987896"/>
    <dbReference type="KEGG" id="aplc:110987896"/>
    <dbReference type="OMA" id="WERANCE"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106743.1"/>
        </source>
    </evidence>
    <sequence length="276" mass="31623" checksum="B5D22CAAE5E3886F" modified="2022-01-19" version="1">MNFTASEDYCGDARVIQHSFIKHHINKLGLRREDTVLDVGCGTGEETAWIAKGVKFITAIDNSEEMLAVAAESNSVCNVAYFKCDAQTVGDNPDWREKFDKVVCFYVLHWVPDELEAIRSISKCLKSAGEALFIIDGQDDNFVLLQATSFLKGHKKWGPYVKDYQSQLRQWTRSASDTEEVFKACGWERANCEVRQHEVYLSETQFKLFMKTCLGETPLIPAADQEDYLQDLWQWGMECSKDKSRAESYRFTTFLWSSTLLNKLSQVRFSKQGKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNX6</accession>
    <name>A0A8B7ZNX6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Axoneme-associated protein mst101(2)-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107129.1">
        <property type="nucleotide sequence ID" value="XM_022251437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNX6"/>
    <dbReference type="GeneID" id="110988161"/>
    <dbReference type="KEGG" id="aplc:110988161"/>
    <dbReference type="OMA" id="IMITMYL"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107129.1"/>
        </source>
    </evidence>
    <sequence length="573" mass="66724" checksum="0F5869F7E0CA8FD1" modified="2022-01-19" version="1">MTNHSLKKRTKCVIGRVQAAMSYCCLTDDTCEPSELFALLQELDRRYFLLQDFRWEFALLDRHQNDLITEDQARFMFEAIHGKLFSKLQWERFLKNRPVPGSGISFAEIEVDLCNIPSRADMAYEEMEEHRQKEEKAKQIEQRKQAEEQARLERLAKMKADQLNKEDEIRKKKSAEKKKEEEMKKEREDEQRRKLEEARGKKEAEEREREEEERRKKLKLEEEKERERQRELEIIEVQQALEAQKEVERKARELQEQEKKEQELAKNAEEEAELAVAREKEALEEANRAKEAIKNAQDAAAKKAAEEAERAAREKVKRERNERIRKDLKVAIKQKDRILLTKSVDEFKKAKLADTDGDLHKAEKILTQFKAKDDLLKAMEHRNLEELEKAIDFVKKYSLEGHMPQEMVRANKMLLGLKRLKRLKDEILNLKQSTVAEIRSYNKPPRAVHMVMIGTYLLLGNKESTLKDWKGMQALVGKTGKDGLKRRVLQCDPTKISVAAAERAKNLLEEFDLEQVRDVSAGAAVFYAWASATIEEVKDIARQKEEGLKPAAHQGGAKTLKHELQSGTLTITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP61</accession>
    <name>A0A8B7ZP61_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Thromboxane-A synthase</fullName>
            <ecNumber evidence="7">4.2.1.152</ecNumber>
            <ecNumber evidence="29">5.3.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Cytochrome P450 5A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">LOC110987874</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="32">Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48856"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:48857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:55556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59720"/>
            <dbReference type="ChEBI" id="CHEBI:131859"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>prostaglandin H2 = thromboxane A2</text>
            <dbReference type="Rhea" id="RHEA:17137"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57445"/>
            <dbReference type="EC" id="5.3.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:17138"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 33">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 34">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="7"/>
    <dbReference type="EC" id="5.3.99.5" evidence="29"/>
    <dbReference type="RefSeq" id="XP_022106690.1">
        <property type="nucleotide sequence ID" value="XM_022250998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP61"/>
    <dbReference type="GeneID" id="110987874"/>
    <dbReference type="KEGG" id="aplc:110987874"/>
    <dbReference type="OMA" id="GYETINT"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="22" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 33 34" id="KW-0349">Heme</keyword>
    <keyword evidence="18 33 34" id="KW-0408">Iron</keyword>
    <keyword evidence="23" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="24" id="KW-0456">Lyase</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 33 34" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="17 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="33">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00036380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00036475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00038872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00040834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00042726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00054825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="RefSeq" id="XP_022106690.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42227" checksum="E696F93D249D679E" modified="2022-01-19" version="1">MSSMINECCDTLVANIKRAEQDGQPIECKRLYGGFTMDSIAWCGFGLKVDSQKNKNDEFVVNARRVFSFERRPLMLLVNFLPFLNPIFEYFDVALMPAKVAQFFSSVTDQTRKLRKEEALSNDRKKQIDMLQLLLNAHNETVEGDDEEAGPQLQTLKGSKRPLTNDEVTAQTILFFLAGYETTNTLLGFASYLLAINQDCQEKLYSEILDAASSRDLVSYDTVGKMTYLDMVINESLRFYPPIAGFFRTCNKTFSHKGITFEKGTQVLINIYAIHHDEKYWPDPDKFDPERFSPERKASIPPMAFIPFGYGPRNCIGMRLALLETKMALVRTLQQYRLDVCPETQIPLKLNAGLFTSPREGIKLRPVARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQE2</accession>
    <name>A0A8B7ZQE2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermatogenesis-associated serine-rich protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107619.1">
        <property type="nucleotide sequence ID" value="XM_022251927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQE2"/>
    <dbReference type="GeneID" id="110988440"/>
    <dbReference type="KEGG" id="aplc:110988440"/>
    <dbReference type="OMA" id="MRPYPFT"/>
    <dbReference type="OrthoDB" id="186791at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029165">
        <property type="entry name" value="SASRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35845">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35845:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15160">
        <property type="entry name" value="SASRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107619.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="30534" checksum="474800B2B956C1D1" modified="2022-01-19" version="1">MALHVTTEIGIPGRKERERRHFPERRGYEKSTVRGRRYIPHGQGSEPDWQPHPHCLQVKYSEQGPDWSSRLRYIPAPTEPEPREDYRLPSLRCFPGRHARSYEEWTFYPEGFHVGRRCQFPADALPEDKNHLASITSTNEVTHSEMLGMNRKLPTMFERRGFYPQASPGDKSYQASEYSPKFHMFGSTRPVVNFGGPPKRKPDTFVPLQELPPYPCEPYKSRERRRNHKEELESVRLLDIWEPAMPLGLPFGCEDRKFIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZT67</accession>
    <name>A0A8B7ZT67_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15">ATPase WRNIP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110987857</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106665.1">
        <property type="nucleotide sequence ID" value="XM_022250973.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106666.1">
        <property type="nucleotide sequence ID" value="XM_022250974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZT67"/>
    <dbReference type="GeneID" id="110987857"/>
    <dbReference type="KEGG" id="aplc:110987857"/>
    <dbReference type="CTD" id="56897"/>
    <dbReference type="OMA" id="IAYTPCK"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="26"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022106666.1"/>
        </source>
    </evidence>
    <sequence length="639" mass="69333" checksum="19D2A549A7F8B393" modified="2022-01-19" version="1">MSSQRAQCPICNREFPMQSMNKHIDSCLLEEHDTDDGAKSSDGPPGKTLLSQRKRARLSSEGAQPAASPGFVERMGSGEDASLDKPKEVESDSESGKRKRLNQWGSLLRPVSKPSKAVVEERTANKMKSKLPVSKSGHNLPQKMPLSDLEATPPSLSQSSLSSQELSVQMPARPAKMEFRPLAERVRPRSFAEFVGQEVAIGHRSLLRQLLESDAVPSLIFWGPPGCGKTTLANIIAQRAKASGRARFVSMSATLANVSTVKDAVTAAANEQRMTKRKTILFIDEIHRFNKLQQDTFLPHVENGTITLIGATTENPSFKVNSALLSRCRVIVLNKLTTDELVLILRRAAAELGVAVLEQGKEVKGNGQEGSSDDKQAESGPADSRSSICIEKTALTYLANLCDGDARSALNTLQMVTESQLAVPQQSANGDSQHYVNGPGVGCGTGPKCPISVSHIKDALQRTHVMYDREGDEHYNCISALHKSMRGSDANAALYWLARMLIGGEDPLYIARRLIAFASEDVGLADPQALTQAVSTHQACHFLGVPACEVVLAQCVIYLAKAPKSSMVECALMSVKKHIQEYEGPLPGVPLHLRPASTQLMRDLGHGKGYVHSAAAGDQRFLPECIKHVDFFDNADLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUL3</accession>
    <name>A0A8B7ZUL3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide-binding domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108782.1">
        <property type="nucleotide sequence ID" value="XM_022253090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUL3"/>
    <dbReference type="GeneID" id="110989024"/>
    <dbReference type="KEGG" id="aplc:110989024"/>
    <dbReference type="OMA" id="KREWNEY"/>
    <dbReference type="OrthoDB" id="5966510at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011:SF32">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="331"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108782.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="58330" checksum="EB770FDEA51B0730" modified="2022-01-19" version="1">MALATNGHGDGKKQVEKWSERDLHKTRHRVPTCSRDLSPVIDYTNLELINSYDGLKGRARNESTEEGHRFFMDNYHRMFANNKPLPCIPSGKRNQPTKNISNVSTGSATSLSCGKQHLEDLQMPETWSHEIADHMAKLHKERKIVDPVIIASNRIKDLRTILKKLPYERTAEDNDIVFTHLKEFPLLADQLSSQELKELCTVAQLDVWKDEDYTVFGNGGFYIILRGVVVPQTEPWIRTKGNPGRFRSPTPILTTTVHTDKKLKELTVGDCFGTLERLEGKEPNSKVLTVLTKTVPCEFLKISSNDYKRITEQIRERHISEKIDLIQACKPYQLWPRQSLHKLAELIKWTKFPENTVLVSEGYLCPFIGFIKSGDCHVLRQVEVIHTLHNGKQEKHQKQVVMGKLKDAESFGEISVLDEEAITCSIVTASDIKLGIITPDRLKELDETTRVLLRQSNERLYGNLTQDDIHEEYIDQEMKREWNQFKHGVVVDVINTKGIRPGYGKWASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV80</accession>
    <name>A0A8B7ZV80_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="14">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110988966</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with EME1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the heterodimeric DNA structure-specific endonuclease complex MUS81-EME1. Part of the heterodimeric DNA structure-specific endonuclease complex MUS81-EME2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022108685.1">
        <property type="nucleotide sequence ID" value="XM_022252993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV80"/>
    <dbReference type="GeneID" id="110988966"/>
    <dbReference type="KEGG" id="aplc:110988966"/>
    <dbReference type="CTD" id="80198"/>
    <dbReference type="OMA" id="PGMLQMP"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000001">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000003">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000001">
        <property type="entry name" value="Putative Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21292">
        <property type="entry name" value="EME1-MUS81_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="16">
        <location>
            <begin position="547"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="90"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="402"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022108685.1"/>
        </source>
    </evidence>
    <sequence length="835" mass="92368" checksum="751D5F4C8BAB1B7A" modified="2022-01-19" version="1">MASSEPAPKKRKKKVDPCPNPLFVKWLSEWRDEAASQGKKTQYAFGKALQALKKYPMELKTGKEAKILDHFGDKICNMLDHKLAKHVEENGELSSSSSDIPCNGARNSVSSPPPPASWRSDDLLVVPPLPDDSAQGDKTRKRRLSNRGPREYVPIYRSGPYALILTLYREYKKPTSRGFMLKNELQREAQPLSEKSFTLPDPGSHYTAWSSMSTMITKGYVSKEGSPARYSITDGGCQLARKLELVEAQFRQHTSGRSSTVQPTASAGQSKKRKEAPRSNTNLPTTAPPPNATSLATYHDAPLPTQGDKLEYWYVDDHGNQVVAKDDAAVSVDDEISIGFLIKANEAALKRSGVRYKRDYTMQVEGGMIFAYLHNDDAAEYCSVPASSTSWAVSSLRHDDPLPSLPSSLSNPTGPPKKKTQRPARKDKQADSLLSTASSVSMSSSYPTTKSDSQCYRASPDLIPTSSSDKLNLATDIVNSALRNSESSELNSQTSCTSTLSSISSLLDRAGSLQGSNSQDSDGRNLASSKEPPVPLYVLQPGTFDIVLCVDNCETAGGSAKSRKQLLLPELQKNGVTLDVRKLQVGDFLWIAREKRVPVPGMLQMPAAREVALDYVVERKRMDDLCCSITDGRFKEQKFRLKQSGLRQPIYLIEDFGSIDHLSIPASTLRQATINTQVVDGFFVKHTRDIKESAAYLTIMTRYLQGHYSNKTLEAYCRDDLEKLPSNPSVTDRVQKLMTFSEVYESSVKNKNTTVTETFAKQLLQFSGLTAEKALAITRRYPTPSDLVGAYESCAMEKDREKLLSHIKYGKLQRNVGPVLSKLIHMFYCTNGPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVR4</accession>
    <name>A0A8B7ZVR4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110988442</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022107621.1">
        <property type="nucleotide sequence ID" value="XM_022251929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988442"/>
    <dbReference type="KEGG" id="aplc:110988442"/>
    <dbReference type="OrthoDB" id="10252328at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001242">
        <property type="entry name" value="Leucine-rich repeat serine/threonine-protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000803">
        <property type="entry name" value="Probable serine/threonine-protein kinase roco4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1390">
        <property type="entry name" value="ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032171">
        <property type="entry name" value="COR-A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF169">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16095">
        <property type="entry name" value="COR-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08477">
        <property type="entry name" value="Roc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Roc" evidence="18">
        <location>
            <begin position="1262"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="2244"/>
            <end position="2551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="900"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1070"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1665"/>
            <end position="1735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1767"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2113"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1078"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1668"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1695"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1777"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="2124"/>
            <end position="2135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="2138"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="2277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022107621.1"/>
        </source>
    </evidence>
    <sequence length="3034" mass="338305" checksum="97C08A0F37FC051B" modified="2022-01-19" version="1">MMELEPMWQMLRLYLAVAEDQSSFHDKSSSEPLDIDANNGLTTMVGVAKNLLPGSDGGSTTAAALGNSGDVDLSLTEHRDFQGKLLHQAAIYSNFALLEDLLKWEQRRYINERDSFGRTALHAVCAAEVSEREESIECVRLLLEAGADPNIAAAERYNYYTPLHVAAKDGKVKIASLLVQYGADLENRDIKRLTPLELARNNYQTDCVSFLQTTQVERERLRSSLEPSLLEACSSVKELRQILRRIGYSAINREYKETPLYRAALGGHLSVVKFLLDHHANGKPNRDTKQTPLYAACLNGHFDVAKLLLQHFPAMASDQTNEMEIPLHAAAKQGNAAVIKLLLEFDYKSALDEKGFCQLDQSAATSTFKSYKGDLPFYLNLRNINGQTALYLACTAGHVEAARALLEYRPGGTVVPNFGQGKKQAYIDVDCYTVIGRTPLHSAVTAGNIEIVALLLKHGADVNLPVKSIKCLFGSRGSNASLVEGRVTEKMHIPKEDNSILCEACSISEYNLDIIAMLLKHGARDPSGKALLSATLSVRSDVVTTILAHTGVHPDPDYVIGEEYQTKIKLFVTELTQTTEGGDCHSKPKTVREAALIARTKVIAQESKKDHSRKGSTYDRRRTFGGLKRAASTLGMFDTPVAIDWHDQNLNDINPEWLVEASLRFNTVLRTYPQDSSIHISVATITRIDISDNSLSHLPLFIFKLPSLQHLNASKNKMCYLPGMPRSTSPMTRTFPGIEDSAWNAPMLRRINLSSNRLVTLPPEIFMLPVLENLNMENNHLRELPFEMWMAPKLKTLNLSRNILEELPCGLYGPSNNNQIAFREVQCRSPSPLPEDLTSDQKRDTFPLLSNQSEKPASGKLARLSEAALKFGKAALRMKDLPRDSANMVISMSGLEASLARRDTIDNSPSESPETSDSEVFEDEEHSEKGYSIVTVRRFRLCSTGSIHGDSAEEENANIDEMNALETLDLSHNKLTHVPVGLPCLAPRLTKLVLCHNKITDFGPMNKYPVGLMDLELSFNCIKDMSNPASHLPVRNKSNVFRLLRSSSAYDPSLGLPDMCYSPTSQYSLAQRGTLQTPSRQSRDSSFVSSPPGSGTPQGPLVQFCKHRRHRVLATLRTLDLSSNQITQMDVIARTVLGASASVEEETPGAPGDSSEDDSKLQLVQSRGSDLEVTLLFPSLNALSVANNMIGEVPSDIQYLTKLSSLKLNGNEKISTLPPELGRLNMYDLKVDGCRLTEPLASMFKTELVKDILGYLRSILDDAKPYTRMKLMFVGKACIGKTTLLNELRKDGVGSTSSVPETFAERQGNTSIGGKTLRGKYLSTVGVDVSEWTYNKKRSKYGKVTFSTWDFGGQEEFYATHQYFLTKRSLYLVLFKITDGMKSINQIQQWLVNIQARAPNSPVLLIGTHYDLVNRPKSKYSREYWPDLKRKIMERFIHIAQPQDVGLPNVIDCIEISCLPMPRNNNLGFLRDRIYDVAFSLTEGRDKEPMLMQRVPTCYLALEKAVMLISSDMRRAGTEPVLHALEYRTEVTRVMLEQYQVSFHSKEDLMHATRFLHNNGILLHYEDSMLSDYFFLDPQWLCDTLAKIVTIPEINPDVKKGVMLIKDLHRKFQDSSVKDFILNLLNKCEVAVTYDNEHILVPSRLPVEGLDMTMIPLIREKDVIQKESPQTTSPSSSASPSPNRCWNRRAVRGVSPNNTSHVRNYSPSPSSMRRNPLGALQIPGGTLSKAESSSMPTLSQQIPTQLRTNNCSSSPPSSMIIPGMPMDQGSMLPEPGSKSSTLNSHSLSSGDLPVSLNGIQNITPVPFQMHEEPLTELDNTEVIPIVNQKAAIRRLYILQYIPSGFWSHMISRFLSDQTFCKVVPLLYPLPERLKVMMSQSALDALEKKYQWTVWQTGVELRFFGATIFHVKEIVKEAILTSVFEQERRPDHIKVVNPDGQEPGGDRAVSLTRSGQLEILIPNQTLNIIQKADSAPIMTETAVESGIEALEGEHIEIASSLQVASRLLSSIMDLIDTLMENFYPSICEPLGITFQGELFITRLVPCNRCWRDYNRLNVDELDEQEWEFVDKFDFDQRQSLLSETPVPRKRSQRGSNLCCGLSCTDHHGPYSDFSEYTERNNSMRPRARPVGRKHRAAISQSKSSDQSESCSQPDTPLVNDFQSQDLLFSDQMKLDLRFTNSVEMNSEMMGDVQVYGFLFEMLVMQAMKTEIVTCPIHGRVKLSTIAPDVVFHDLGPALLVDRATLEVRRLLGSGTFGLVFQGQTSRSSLDTKVQVAIKMLQPFPPGQGAGQTDRRRYEAENAKWHRDPLRFSCEAFRTARKELSIMLNLEHPQIVPLIGFCRQPMSLILELAPEGALDSKLEDYKRVGARLTPCTFQKILVQVSSAVAYLHQKGIIYRDLKAENVLVWCLPAPHSSDSCVKVKLADYGISVTAMPSGTKGYGGTPGYMAPEIVQYDGKEKYTEKVDCFSFAMFMYELMAIQRPFENLVGKDFGRLSEIIKQLIKDGQRPVLTKKEKLYPTYMVDLMAWCWAQDSRDRPSMEQINAISRMPEFPNLREIMSPQDNEKVTCACAPPLFLNGSITDSDSDDLAAVQPCVWMAQCIDKNGLGNPDEASVLVLNVDRSPGESSTCVKFNVSSGCVECMCAVVDTMWLGLTSGAIAVYGAVHNAYQELCPMFTLPLCLGKVQVPKAMVHVSALGEVMVATDHRIIVVSEDRGLPDQTVMLKYVEFRREVFTLAVVPAFGNLGDKSFEIWCGQSEGHINIVNASDLSIAKTDLNHQQALDCVGKVSRLVTYDLDLMEEMGLHHVWSWVQPGPFIYKWNVKSKKIEGTLDVITALATCRSNSKPRSRRNVRPMSGRGRIFGVPWPEMGGWAMRNQVSSLAVFRQYLYVGVSSGNLLVADPHSLKPLCVINCHEGPVRTIVPVATEPWTPSEMQADEAAAEAEVEGQEGGAAVVVTVGRGFNDLIGGYVNSPSRVKGHERLEWYFLLWETANWEQGCPQPSLKGLGLENIVGKNNGSLYGTKMTWDEKKMPQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWE5</accession>
    <name>A0A8B7ZWE5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Transcription factor RFX3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110989563</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109744.1">
        <property type="nucleotide sequence ID" value="XM_022254052.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109745.1">
        <property type="nucleotide sequence ID" value="XM_022254053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWE5"/>
    <dbReference type="GeneID" id="110989563"/>
    <dbReference type="KEGG" id="aplc:110989563"/>
    <dbReference type="OMA" id="CQCDYAM"/>
    <dbReference type="OrthoDB" id="10056949at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000017">
        <property type="entry name" value="transcription factor RFX3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF33">
        <property type="entry name" value="RFX, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="7">
        <location>
            <begin position="193"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022109744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022109745.1"/>
        </source>
    </evidence>
    <sequence length="710" mass="77682" checksum="0EF99D5C9E760CA9" modified="2022-01-19" version="1">MQAISATTQQQQISTPTIITTHQAQHQPSTQTIQAQQFVQVAAPVTEPVKDVPSAGTTVTLQTIPVSQTSQQGIYQGHVQYVDGGDHSSSIYANGAMANYPYSEATTMYTQATPAGGATYYSSGQALTSSALGSIQTLGGSNMSVGGTTIIGGNLLGGPQLITQQGGTYLLQGHTMDGNGHPLTHTTRASPATVQWLLDNYECAEGVSLPRSTLFNHYMRHCQEHKIDPVNAASFGKLIRSVFLGLRTRRLGTRGNSKYHYYGIRIKSSSPLNQYQEESGHTAMRQQPINSAKRFKPSPIGSKQDGTEGGGAVSGSGGGAQDPVQTQTQQHQQFLGDASMALPDFGELKFGTTPLPEGVTQDDVKAFQALYREHCEAILDVVVNLQFALIEALWQTFWRNPPADAQQNEGDVEKRLPKAKLISLCQSSPVQEYVKHYDHVLYQGLVEVLIPDVLRPIPSALTQAIRNFAKSLETWLKNSMTGIPQDMISLKVGAVTAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDDQMVQRLEQDFKSTLQEQNSLEQWAAWLEGVVTEVLEPHENSPNFAKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEFMFYLIEHRVAAATGETPIAVMDKVDSSTELSMNNSLPTSNSVNNTTSNTNTIIVNIPTTSAVNSVVKVNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX06</accession>
    <name>A0A8B7ZX06_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="16">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">LOC110989688</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="16"/>
    <dbReference type="RefSeq" id="XP_022109943.1">
        <property type="nucleotide sequence ID" value="XM_022254251.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109944.1">
        <property type="nucleotide sequence ID" value="XM_022254252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX06"/>
    <dbReference type="GeneID" id="110989688"/>
    <dbReference type="KEGG" id="aplc:110989688"/>
    <dbReference type="OrthoDB" id="547665at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048179">
        <property type="term" value="C:activin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048185">
        <property type="term" value="F:activin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017002">
        <property type="term" value="F:activin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14053">
        <property type="entry name" value="STKc_ACVR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23618">
        <property type="entry name" value="TFP_LU_ECD_Wit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000099">
        <property type="entry name" value="Serine/threonine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000094">
        <property type="entry name" value="Serine/threonine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017194">
        <property type="entry name" value="Transform_growth_fac-b_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037393">
        <property type="entry name" value="TGFRII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665764" description="Serine/threonine-protein kinase receptor" evidence="17">
        <location>
            <begin position="34"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="232"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="60"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="135"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037393-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037393-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037393-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022109943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022109944.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="61814" checksum="FEB3415FFB75EAE4" modified="2022-01-19" version="1">MAPLITRSCDFVFKVCLLLWLSYSAVLLRSVTGASVNFPLSRVSCFEYDSQKCSGNDSRCSTVQDCDIEFGYADLDLELMETNKCFILWQNTSAGLEVIMKGCWQSSFSNDCVEEDRCVSHETYADGENRYFCCCSGDLCNHQFYHDPQPKPTSSEHPFQNPGHTPEKKRNRSNIILTTVLYTLVPITAFTIIIISVYWICRRYRYSLLTSVPNSEPSPLSPPSPVLGHRPIQLLEIKARGRFGAVWRAQMGHQQVAVKIFPLQDRQSWVTEQEIYSVPQLRHENLLSFIGTERRGEGMDQELWLITEYHPRGSLCDYLKGNLLSWSDLCKISLSMAYGLAYLHEDLPATTLCSAKPAVAHRDFKSKNVLLKNDLSACIADFGLACKFEAGKSPGDTHGQVGTRRYMAPEVLEGAIQFQRDAFLRIDMYACGLVLWEIASRCTAQEGPVDEYMLPFEEEVGQAPTLEDMQDVVVVKRLRPVIRESWLKHSGMRLLFETIEECWDHDSEARLSAGCVEERLSQLLRYNVCTAPLISLTPSPPKESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZ53</accession>
    <name>A0A8B7ZZ53_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Synaptotagmin-1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110990155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110704.1">
        <property type="nucleotide sequence ID" value="XM_022255012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZ53"/>
    <dbReference type="GeneID" id="110990155"/>
    <dbReference type="KEGG" id="aplc:110990155"/>
    <dbReference type="OrthoDB" id="10259057at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00276">
        <property type="entry name" value="C2B_Synaptotagmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF227">
        <property type="entry name" value="SYNAPTOTAGMIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="257"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="394"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022110704.1"/>
        </source>
    </evidence>
    <sequence length="538" mass="60726" checksum="EB7CAA340A8B463E" modified="2022-01-19" version="1">MHNFSVVPLLREPQPVSPPTPEEGYAPLPYPIPVIIAILVGAQIVIIVSILLYVLSYGRNMEKSAYREIGRSPLSGSRFWKKVRKKLGLREGDRCAKASAKYSIQDATFLEKWREKKREMVVPHHVQTMSRPIEFSIPTKTETLVRPKASEKLRQFPLPPMRKPSKDPWMSPSFKRPRNPNLSSAMRTRSLQTEERKASNNRMARSHSVPINLGEAASALADQVDQTSAYQTAIGEIEPDLYRIDEQHELYTPSKFGLGKLSFSLFYDEREGQLTVYLIQAVQLPARTERATADTYVMVSLLPDEEKKSATSKVHRRTLNPIYRQNFIFRVPEEDVIDTVIKLTVVGLDGYSHPVPIGQVVYPLRTHDFGSSSSDVSQPIWRDIEKSDSPEEPRQGDILVSLTYLPTAERVTVAILKARNLRLPESEEPEARKLVMDTFVKVTVVKGDKVVKNKQTSVVRRNANPTFNEAFTIDMSSEDEQVCIVFAVCLRVNPFAGHKTLGRCLVGPDEKATGDGAAHWRDMMATPRSAVAEWHPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZG4</accession>
    <name>A0A8B7ZZG4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110824.1">
        <property type="nucleotide sequence ID" value="XM_022255132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZG4"/>
    <dbReference type="GeneID" id="110990241"/>
    <dbReference type="KEGG" id="aplc:110990241"/>
    <dbReference type="OrthoDB" id="6158042at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22343">
        <property type="entry name" value="PDDEXK_lambda_exonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051703">
        <property type="entry name" value="NF-kappa-B_Signaling_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019080">
        <property type="entry name" value="YqaJ_viral_recombinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46609">
        <property type="entry name" value="EXONUCLEASE, PHAGE-TYPE/RECB, C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09588">
        <property type="entry name" value="YqaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YqaJ viral recombinase" evidence="1">
        <location>
            <begin position="125"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022110824.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="30994" checksum="AF839560EB1D6C18" modified="2022-01-19" version="1">MECAQASGKVLVGARVGEVMVVETDDNERNSVSLAEFPKMQEDKKSTNSTVTGADKWAFSPEQKPRTSRLSQWVVPRCKGTVDEQPVMDVTVKQLKVDEMTTGCGIESTLSDTRVPYCRVNDNEKLTEFQHFEPFAAKKYSHMNGSGHAVRLEKCGLVIDPKAWSLGASPDRKVVDFLAESPFGILDMKCPEKQKDEDPLTACHDPHFCCKLEGGKPVLKKDHPYYTQVQGQLALTGAEWCNFVVCTHKGLIIQQITFDSAFWNTLYKKLADVYFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A007</accession>
    <name>A0A8B8A007_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC110990148 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7 8" type="primary">LOC110990148</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110690.1">
        <property type="nucleotide sequence ID" value="XM_022254998.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110691.1">
        <property type="nucleotide sequence ID" value="XM_022254999.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110692.1">
        <property type="nucleotide sequence ID" value="XM_022255000.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110693.1">
        <property type="nucleotide sequence ID" value="XM_022255001.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110694.1">
        <property type="nucleotide sequence ID" value="XM_022255002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A007"/>
    <dbReference type="GeneID" id="110990148"/>
    <dbReference type="KEGG" id="aplc:110990148"/>
    <dbReference type="OMA" id="FNTSSWE"/>
    <dbReference type="OrthoDB" id="9979440at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022110691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022110692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022110693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022110694.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28368" checksum="388A508DBE13EA75" modified="2022-01-19" version="1">MTSNFLMRLLKRGSGPPRPQVDMHALFTSSQMSTMILQGQLSVHEPWRRNKKKPKIIYACLYTNDSSPFIVWYTDKAHKKPRGFFNIRGGKIAPVGEFSFQIAFKDQTSQIYKFNTSTWERREEWLHLLRKESRKEVQMPLIETICKQDYHVSQDDLAITQTADQKARQQQLRPSGRGIAGQSAPVHRRRSAAPSSCSEAEASRTSRRAGLSRGDPLSWKSTRRPSARQYRVRGGLYGHQRFVVADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0A5</accession>
    <name>A0A8B8A0A5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beclin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110990415</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endosome membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111109.1">
        <property type="nucleotide sequence ID" value="XM_022255417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0A5"/>
    <dbReference type="GeneID" id="110990415"/>
    <dbReference type="KEGG" id="aplc:110990415"/>
    <dbReference type="CTD" id="8678"/>
    <dbReference type="OMA" id="EWDVYKA"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000001">
        <property type="entry name" value="beclin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029318">
        <property type="entry name" value="BH3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15285">
        <property type="entry name" value="BH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="13 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beclin-1 BH3" evidence="21">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="22">
        <location>
            <begin position="137"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="20">
        <location>
            <begin position="267"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="147"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF15285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022111109.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="51592" checksum="B9401B42A0F5555D" modified="2022-01-19" version="1">MSNSSHSSDSQRSGVATTHVSFVCQRCSQPLKLDPSFSSLDSQTYIDLTAPLLTAGSGKATPLLQSTDSTEPFELEKNDGVSRKRIQPVRYPSQDSGQEFTLLGEAASSRMENVSHRIKVASQLFDIMSGHSDIDHPLCEECTDSLLDQLDQQLKITEDECKHYRESLEKLTDGEDNEDEATLEAEIEMLKANETELIKQLEETESERHKIAQEMQQQKKELEQLEAEEERYWKEYNQYKQQLVSMKDEQRSIDNQLRYTQTQLDQLSKTNVFNATFHIWHNGHFGTINNFRLGRLPSVPVDWSEINAAWGQTVLLLHSLAQKMNFKFKRYRLVPCGNHSYLESLQDKSKQLPLHGSGGFRFFWDTKFDQAMVAFLDCLQQLEEEVERGDTSFCLPYKMSGGKIEDKSNGATYSIKIQFNSEEQWTKALKFMLTNLKWALAWVSSQFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0R8</accession>
    <name>A0A8B8A0R8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110990080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110580.1">
        <property type="nucleotide sequence ID" value="XM_022254888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0R8"/>
    <dbReference type="GeneID" id="110990080"/>
    <dbReference type="KEGG" id="aplc:110990080"/>
    <dbReference type="CTD" id="58509"/>
    <dbReference type="OMA" id="HIDFWND"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="6">
        <location>
            <begin position="237"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="5">
        <location>
            <begin position="603"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="437"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022110580.1"/>
        </source>
    </evidence>
    <sequence length="727" mass="85327" checksum="365BCBA78A7AF8D7" modified="2022-01-19" version="1">MGRSGKRKEISRSRSRERKRHRDKKHERRRSSSEYSSSENSSDDGRRRHQHRRRSRDGSRSESRSRSRSPRPKKRHKHRKRARSRSRSGSPAPHRKDSRRTEQQFEPRQAPLTKEEKRQKKELLKLTETVEQKRARRLAKKLAKDRKRKEEMGWDEEMMGYTNADNPFGDPNLLDTFVWHKKNETAGLGGLAHEHLKGMMKGKQVENRLELQKVKQRRIEREKEREQREKELEELQRMREAESFKEWEKQEDSFHLNQAKLRSKIRIQDGRAKPIDLLAQYVSADLDDDLSVEMQEPYNVLRGLTIIDLEDLLEDIIVYKELEKDSNLEFWKDMTVIAEDELAKLKKISPEGQDGADRREGINASVSTEVAGVFRGKKHSQLLALKEQIMRRIKSGNAGVDIGYWESLLQQLNAHMARARLKEQHQERLKRKLNSLRQQQGVVSDPRGASPQATAGFDPSEIPLPSDSDGEDHEIRRRIKKEPESSEEAGPTQAEGGAPSKSAEEPESVLTQADLEEECITEFEKGGYSPKLVDPKALPPETLIFDPDEDRAKLLRIRQQLITTGSAENTVELEFIKKARAGMDSDEATFAVEVDVQSKPYLWSDKYRPRKPRFFNRVHTGFEWNKYNQTHYDMDNPPPKVVQGYKFNIFYPDLIDKRKTPEYTLTPCPENEDFAVLQFHTGPPYEDIAFKIVNREWEYSHRHGFRCQFNNSIFQLWFRFKRYRYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A181</accession>
    <name>A0A8B8A181_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC110990186</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110745.1">
        <property type="nucleotide sequence ID" value="XM_022255053.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990186"/>
    <dbReference type="KEGG" id="aplc:110990186"/>
    <dbReference type="OMA" id="CAIDNCE"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120025">
        <property type="term" value="C:plasma membrane bounded cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048592">
        <property type="term" value="P:eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="25"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000247">
        <property type="entry name" value="Delta/notch like EGF repeat containing"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000279">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000050">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000537">
        <property type="entry name" value="Notch 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000434">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000565">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000006">
        <property type="entry name" value="Versican core protein-like isoform 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF35">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01983">
        <property type="entry name" value="NOTCH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="28"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="27"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="33"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 20" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16 18 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 18 20" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 20 22" id="KW-0732">Signal</keyword>
    <keyword evidence="8 20 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034647561" description="Delta-like protein" evidence="22">
        <location>
            <begin position="17"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1589"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="24">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="219"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="294"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="332"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="408"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="446"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="484"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="522"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="560"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="597"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="634"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="671"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="708"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="745"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="782"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="819"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="856"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="893"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="930"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="967"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1004"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1041"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1078"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1115"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1153"/>
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        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1190"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1227"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1264"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1301"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1338"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1393"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="1431"/>
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    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
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        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
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            <dbReference type="RuleBase" id="RU280815"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1N1</accession>
    <name>A0A8B8A1N1_ACAPL</name>
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            <fullName evidence="3">Uncharacterized protein LOC110990795</fullName>
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    </protein>
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        <name evidence="3" type="primary">LOC110990795</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111589.1">
        <property type="nucleotide sequence ID" value="XM_022255897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1N1"/>
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    <dbReference type="KEGG" id="aplc:110990795"/>
    <dbReference type="OrthoDB" id="5798273at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34717">
        <property type="entry name" value="EG:BACR7A4.20 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34717:SF1">
        <property type="entry name" value="EG:BACR7A4.20 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034448790" evidence="1">
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            <begin position="18"/>
            <end position="179"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="SignalP"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    <sequence length="179" mass="20189" checksum="D532098588616947" modified="2022-01-19" version="1">MDIFAVILAVVVVLASAYVAANLASPDRVPLHDVYAVPGRWYLLKYVTAKWLLWWSRERKCTIKKRTMNYHMMQDKTKDNGEMEFYNGTEKGQNCLYISGASNGGTARLTVRVSVQPDDRRDVWFLLRLPDVGDLVLPGHPDCVAENVRPGEGFSGAGLCCTPIEPLQIWRILFNGLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1Y7</accession>
    <name>A0A8B8A1Y7_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990931</fullName>
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        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
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            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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            <authorList>
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111699.1">
        <property type="nucleotide sequence ID" value="XM_022256007.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="aplc:110990931"/>
    <dbReference type="OMA" id="CITIPMV"/>
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    </dbReference>
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        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111699.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="24257" checksum="F6CB54DA1F096893" modified="2022-01-19" version="1">MSVGRNAGLHLAAPRLASPIDSLIRVSRRVGRARDIRPRTQGTSARPTPARTGTAGPAPPGTVEAGGALRRAGRPGGRCGEAARRRAQPVVPSSTGRPAQPRPVSRLSDRPPPGRGSRGGRRSPNRPAYAGPDAQPVAGALPGRSACCWARRRPETPARRPXATFARGPRAPQRGRHRPGRGPPARRHLGRSRRAGPSGGLGGPARLPLRGGGARAGAARRPFLGRAAGATTAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2E0</accession>
    <name>A0A8B8A2E0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Amiloride-sensitive sodium channel subunit alpha-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110990442</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111140.1">
        <property type="nucleotide sequence ID" value="XM_022255448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2E0"/>
    <dbReference type="GeneID" id="110990442"/>
    <dbReference type="KEGG" id="aplc:110990442"/>
    <dbReference type="OrthoDB" id="10051479at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF248">
        <property type="entry name" value="PICKPOCKET 17, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022111140.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="61298" checksum="16E27AA32455FA3C" modified="2022-01-19" version="1">MYHQESGSQEGLHLAKRKVSPMTVEDISAEDGAAPAAPPDPAASAKQTSLLYVVSHRLAESGAHGIPNIQRANSNFRRVAWTLLFLAGFGMFIYQGCDLIIKFYKWPYNVNIEVRTPKRVEFPAVTWCNLNPIRKDALADFTDLRSLLEGGSSSCGTAVNATFGGYPGDWESADIDYELEDCTSQTVDAAIDIVGAMPYQERAVTGHRLNDMLLMCTFQQKPCSPKNFTSFYNSRYGNCFTFNSASRGVAPLKVTRTGPSYGLSMELYIQQDRYITGVETGAGIRIMVHNQTEMAFPEDIGANIAPGTESFLGLYRAMVNRLSDPYGDCATDFTQDNIFKEQFKRLEYTKEACEKDCFFRAVLLDCNCAYINYRYNDSQAPCNSSVKAVKTCIEKVENNFTSGELRCGHCHKSCNETRYQISFSNSKWPNREYMETVRKNIQESNKETISLIKNNSYFIEDNVLRVNVYFDSLNYDDIFQTAAYTLGSLVSDLGGQVGLWIGVSVLTLFEFLELMIDIFVLISTRCRAGGENRRIGKTGQENSRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A4U3</accession>
    <name>A0A8B8A4U3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Piwi-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15" type="primary">LOC110991080</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111916.1">
        <property type="nucleotide sequence ID" value="XM_022256224.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111925.1">
        <property type="nucleotide sequence ID" value="XM_022256233.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111935.1">
        <property type="nucleotide sequence ID" value="XM_022256243.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111945.1">
        <property type="nucleotide sequence ID" value="XM_022256253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A4U3"/>
    <dbReference type="GeneID" id="110991080"/>
    <dbReference type="KEGG" id="aplc:110991080"/>
    <dbReference type="OMA" id="CILNTAN"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000014">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="PAZ" evidence="9">
        <location>
            <begin position="399"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="10">
        <location>
            <begin position="676"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022111916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022111925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022111935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022111945.1"/>
        </source>
    </evidence>
    <sequence length="983" mass="109563" checksum="3554E25FDE1BC8B6" modified="2022-01-19" version="1">MSGSGPPGLGRGGRGAALMAVLQNPIRRPGQEPSASSTSGHSPPERASPSPPSSESAGPGVAARVQQQNGHSGARPSQSGEGAATKPQPSVGRGLASLYQQMQLSRGNSPVSSGSSSPSSGAVTPSGTPTPPSTGTGTPPAKPFGRGIAGLSARGSPTAVPAFGRGIAGLKQKSPPLAQTPAESSPHSPLASPTSPQGTGTTTPQLQPQAAASAVRDKPEVQVNIPPPGTSGAPIKVATNYLPIKFETEAIWQYAVSFSPHIESKKMRMGLLYTYLDNISKVRAFDGTILFLPVQLKEKVTIFKTKGLRDNTEFEVKIQLAKALQPKDCIQLYNVIFRRIMRILSMSQVGRHYYSPDLATMIPQHKLEIWPGYVTAIHEYSSGLMLQLDVSHKVLCYQTVLDTMTEIYRRNEDTFKDECTRQIVGTIVLTRYNNQTYRVDDIAWNKNPLSTFMYHDKEEMTFVEYYKKHYDKEITDMGQPLLINRPKKEQLKKPGSKASVICLVPELACRTGLTDEMRSDFRVMKDLAFHTRITPAQRHVSLRKFIDNIYQNRDALKELTNWGMSVDRDILTMGARQLRPEQIRMQNNTIVANPEADWGREMTRDRATLPVDLNHWLLVFCKRDASRSSDFLKMMERCCPQLGIRIQPPVRFQLQDDKTQTYLNCIRDAINPQLQLVVIIFPTSRDDRYSAVKKLCCVEKAIPSQVIISRTISQQQKLRSVTQKIALQINCKLGGELWSLDIPVSKMMVVGIDVYHDPARGGKSIGAFVASTNKLLTRWYSRVCFQTPQQELIDGLKLCLVASIKKYHEINHDLPQKIVIFRDGVGDGQLNIVATYEQQQLSACFEMFGETYKPSLTIVIVQKRINTRIFAASNGRQLENPAPGCVVDHTITRLNWYDFFLVSQHVRQGTVTPTHYVVVYDTSKFNADQMQRLAYKLTHLYYNWPGTVRVPAPCQYAHKLAYLVGESLKREPALELSDRLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A6U1</accession>
    <name>A0A8B8A6U1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hyalin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111721.1">
        <property type="nucleotide sequence ID" value="XM_022256029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A6U1"/>
    <dbReference type="GeneID" id="110990964"/>
    <dbReference type="KEGG" id="aplc:110990964"/>
    <dbReference type="OMA" id="IICPENI"/>
    <dbReference type="OrthoDB" id="5948052at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HYR" evidence="2">
        <location>
            <begin position="74"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111721.1"/>
        </source>
    </evidence>
    <sequence length="192" mass="20990" checksum="8F3F8E982B576DE8" modified="2022-01-19" version="1">VNIICPENITVSANLNNFAYVFWSPPVLSFSGVDQSVTVISDHDQGQRFDIGTTLVTNRILETESQCQFSVTVKDDEPPKVSGCPDDVIIPVTSSSQLVTHSWIPPILTDNSGQDVSVTFNCSPTTFSECNRAGNGSFAVGDTTVRYTARDMSENRNVCAFTVTGLCICLSVQFLVFVECSIEYKDEIEKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGA0</accession>
    <name>A0A8B7XGA0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Transmembrane protein 177-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6" type="primary">LOC110973363</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079813.1">
        <property type="nucleotide sequence ID" value="XM_022224121.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079814.1">
        <property type="nucleotide sequence ID" value="XM_022224122.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079815.1">
        <property type="nucleotide sequence ID" value="XM_022224123.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079816.1">
        <property type="nucleotide sequence ID" value="XM_022224124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGA0"/>
    <dbReference type="GeneID" id="110973363"/>
    <dbReference type="KEGG" id="aplc:110973363"/>
    <dbReference type="CTD" id="80775"/>
    <dbReference type="OMA" id="VTSRWEI"/>
    <dbReference type="OrthoDB" id="110174at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026620">
        <property type="entry name" value="TMEM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022079813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022079816.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="33756" checksum="8099BBD0A7DFFC12" modified="2022-01-19" version="1">MVFQGFLQFIRRPRNVVIFSGAVATGVFCIKLAPHAFPSKVYRPLVEAYKGGHKIAPTESQLSEFHKVCQDIGVNPGSYSVFVTSRWEIRSRGLAWLPNGVQFGIPAILKDNPDLSAKRFSDPIKTTADSEEGRAFRNSLNLSESARKFSLAREVIKIKRNATASSVVLAPVVTLANFAGVFAAQVLFPLPLYANVALVGTCFVMIYQFLMGVVNEREDLITDDKVAELGEEYVRGGVEFYEKKIQKNIALRKIMGRRGEQMYTYYGNEVPGWIYSAGASNTQERDRLKKRLEEMERKGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGW5</accession>
    <name>A0A8B7XGW5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">carbonyl reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.1.1.184</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110973486</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.184" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022080038.1">
        <property type="nucleotide sequence ID" value="XM_022224346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGW5"/>
    <dbReference type="GeneID" id="110973486"/>
    <dbReference type="KEGG" id="aplc:110973486"/>
    <dbReference type="OMA" id="FYFYMST"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF4">
        <property type="entry name" value="CARBONYL REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022080038.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30654" checksum="49F4A7FD2B8346C6" modified="2022-01-19" version="1">MSQTPRRIALVTGANKGIGFAIVRALCKQLDNGIVYLTARSEERGREAVAKLSQEGLQPKFHQLDITDPASVTKLRDFLKETHGGLDILVNNAGMAFKVNATESFGVQASVSMATNFTALLEMNRVLVPLIRPHGRIVNVGSFTGRLYAFEKMSKELQGRFQGVKTEQDVEQLMQEFVTCANAGDHMSKGWANSAYATSKMGVIALTRVQAADIAKDKTKEDILMTCCCPGYVSTDMSSFKGTKTIDEGAITPVYCALLPPGSAEFNGKMFSDKELYEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XI83</accession>
    <name>A0A8B7XI83_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-crystallin 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079645.1">
        <property type="nucleotide sequence ID" value="XM_022223953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XI83"/>
    <dbReference type="GeneID" id="110973259"/>
    <dbReference type="KEGG" id="aplc:110973259"/>
    <dbReference type="OMA" id="AKEPNIA"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000258">
        <property type="entry name" value="Glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000030">
        <property type="entry name" value="Glutathione S-transferase S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01205">
        <property type="entry name" value="AMPS.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00363">
        <property type="entry name" value="AMPS_(cytGST):_Alpha-__Mu-__Pi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079645.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23969" checksum="7395F2E9057D3269" modified="2022-01-19" version="1">MPSYKVVYGNNRGLAEPTRMLLACAGQEFEDVRYTSEEWQNHKAEAPMQQRPYMEVDGKKIPQSRAMHGFVAREFGLNGSNNEETTKIDVIIATLEDVRLSVGRVVFYEKDEDKKKEKVLELYAQTVPKSFAALEKMLVANNGGDGFFVGSKISRADIFFYVSMEFMAAVQQDFPVQDEVRKSPKLAALMERVAKEPNIAAYLAKRPQTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIB1</accession>
    <name>A0A8B7XIB1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Band 4.1-like protein 5 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110973381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022079862.1">
        <property type="nucleotide sequence ID" value="XM_022224170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIB1"/>
    <dbReference type="GeneID" id="110973381"/>
    <dbReference type="KEGG" id="aplc:110973381"/>
    <dbReference type="OrthoDB" id="6235974at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
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    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
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    </dbReference>
    <dbReference type="CDD" id="cd13186">
        <property type="entry name" value="FERM_C_NBL4_NBL5"/>
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    </dbReference>
    <dbReference type="CDD" id="cd17108">
        <property type="entry name" value="FERM_F1_EPB41L5_like"/>
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        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.10.20.90:FF:000024">
        <property type="entry name" value="Erythrocyte membrane protein band 4.1-like 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000003">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
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    </dbReference>
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        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
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        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF25">
        <property type="entry name" value="MOESIN_EZRIN_RADIXIN HOMOLOG 1"/>
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    </dbReference>
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        <property type="entry name" value="Second domain of FERM"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
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        <location>
            <begin position="39"/>
            <end position="323"/>
        </location>
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        <location>
            <begin position="514"/>
            <end position="536"/>
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            <begin position="620"/>
            <end position="645"/>
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            <begin position="826"/>
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            <begin position="854"/>
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            <begin position="523"/>
            <end position="536"/>
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            <begin position="826"/>
            <end position="836"/>
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            <begin position="862"/>
            <end position="887"/>
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    <evidence type="ECO:0000256" key="3">
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            <dbReference type="PROSITE" id="PS50057"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    <sequence length="938" mass="102418" checksum="56C962BD82E01871" modified="2022-01-19" version="1">MMRFFSGRFSRRFRRQDRAGARGRGTEVHVPAAKHKHVFVCKVLFLDGTDKVYEVKKNAKAEELYNQVFYTLDVVEKDYFGLSFPDSQNILNWLDPTKTLKKQFKHGLPSLLKFQVKFYSSEPNNLHEELTRYLFFLQLKQDIHTGKLEPPVTTAVELAALSLQSELGDYDPTEHTPELVSEFRFVPFQSEDMEVEIVDKFKEMKGQTPAQAELNYLNKAKWLEMYGVDMHHVMGKDGNSYSLGLTPTGILVFEGNQKIGLFFWPKVTKLDFKGKKLHLAVNEDDDRGNEQQHNFVFRLSSNRSCKHLWKCAVEHHAFFRLRGPVKHRDEKQGFIRMGSRFRYSGRTEFQSAKTNRSRRSMMIERRPSQRFSRRPSYAQKRAAHLQESAAHAAAHAAANQMAGLDISNARTLPSHASTAMPQSMTVSADVTPIIPPTTPNSTANASSPGLLSDSMNLVETNIDTGATAEIVPLSARQDVTGGTVVTDDDDMVDPMSPGLSESELVQAKLKGLEKEPCSIQPNPRTRPQTQPTPAAATAAASLNSNFLKQNNQQTSKMLVGGQLTADQIKINPLKAALDERNQTPVGTTDKISDLKYKLLQPESAKNLLKVEMDDGAFRRHNSLPPHNRVDPPPRPASKSFSSMQNVKKQPVFSGVHSEKEGLVVNLSRSPELGHLDDPMDDPMTDPLTPPPVKSAEPAARTNQLLVNGDGRLRSISNPDMQQNGVSPNMLQPLQEDEATTTLTAAKNKTDEQKINNIVAAAALESSQAGSKPQTEGAAVFSLVGQQSPGGATFSVVGSTASEGALQAAKSTPPPTMSKNVEISMATTTQTASTPPSLANSGRVSSVASSTSATSKLEALESSPKQSTSASNLRKISSLRQKQQPVVNGVTSNTTTAAPAASLGLGSQATAGLTADPFQDLNMSASGGSGKRCTLTTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIS1</accession>
    <name>A0A8B7XIS1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110973369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110973369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079835.1">
        <property type="nucleotide sequence ID" value="XM_022224143.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079837.1">
        <property type="nucleotide sequence ID" value="XM_022224145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIS1"/>
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    <dbReference type="KEGG" id="aplc:110973369"/>
    <dbReference type="OMA" id="TLWYFWA"/>
    <dbReference type="OrthoDB" id="10480653at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665438" evidence="2">
        <location>
            <begin position="39"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079837.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26472" checksum="4F1714EBA53B65D5" modified="2022-01-19" version="1">MKLTNERTSDWKSGVDFGLRWALLAACLCQLAYKGCHAAVDCPDQNGVIRYRCEDSAYCCGNGECCLLDNGFNIFTLWYFWASIGLGLVICIAASRVFCKSKRHSQVQVQDISKAANHLQVGDVPRPRPHLQPQPQPLQQTQPQQVVVVPVVYNQPAIRVPQEGAFNVSGSVLPSGAMTTAMHPGINQPQGRRRVMMMNGRPPPGLVQPAPALPGEFVRPFGPGYHQPSLYGPLPPGYVPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJ87</accession>
    <name>A0A8B7XJ87_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110973912 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110973912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080864.1">
        <property type="nucleotide sequence ID" value="XM_022225172.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973912"/>
    <dbReference type="KEGG" id="aplc:110973912"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11781">
        <property type="entry name" value="SH3_Sorbs_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11782">
        <property type="entry name" value="SH3_Sorbs_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11780">
        <property type="entry name" value="SH3_Sorbs_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000055">
        <property type="entry name" value="PDZ and LIM domain protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000001">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003127">
        <property type="entry name" value="SoHo_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02208">
        <property type="entry name" value="Sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00459">
        <property type="entry name" value="Sorb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50831">
        <property type="entry name" value="SOHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0965">Cell junction</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="11"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="SoHo" evidence="9">
        <location>
            <begin position="512"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="2466"/>
            <end position="2525"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="2538"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="2682"/>
            <end position="2743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKS8</accession>
    <name>A0A8B7XKS8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19 20" type="primary">LOC110973867</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080740.1">
        <property type="nucleotide sequence ID" value="XM_022225048.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080741.1">
        <property type="nucleotide sequence ID" value="XM_022225049.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080742.1">
        <property type="nucleotide sequence ID" value="XM_022225050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973867"/>
    <dbReference type="KEGG" id="aplc:110973867"/>
    <dbReference type="CTD" id="1639"/>
    <dbReference type="OMA" id="LFEMEPV"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="16">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
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            <begin position="75"/>
            <end position="189"/>
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    </feature>
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            <begin position="828"/>
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    </feature>
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            <begin position="1146"/>
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    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="982"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
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            <begin position="1222"/>
            <end position="1249"/>
        </location>
    </feature>
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            <end position="89"/>
        </location>
    </feature>
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    </feature>
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            <end position="150"/>
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    </feature>
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            <begin position="833"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1152"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00016574"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022080740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022080741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022080742.1"/>
        </source>
    </evidence>
    <sequence length="1315" mass="144766" checksum="DF3C1A7625EA4F4F" modified="2022-01-19" version="1">MAEKPVKTGSKVEIIGKGLHGKVAFVGVTAFASGKWIGVVLDEPKGKNNGIVQGKKYFSCPDNHGIFVRQSQITVEESPPGSGTASPGTASPAPTGIPKADKLSPSGKKQPASTSIKSSESPAEKSLSVRRIAKYSPARRSTEGLSRSRVESPITDAPSTPSSRLPQPPTAGRPAISGGDAQSSEQVGSLKLEVQDLKEKLETLRIKRAEDKMKLKEAEKMKIQLAQLAEFKAKMIEAKNDLERQLQEAKKEAREATEARERYQEEMSEVAETIEMATLDKEMAEEKCDSLQAEVDTLKEKVEELTLDLELLRGEIEQGGTDGASANYQLKQMEQQNARLKEALVKLRDLSNAEKHEHQKALKDKDKIVAELKETKAQKESANKALKDAENQIIELKEQVDAALGAEGMVETLTDRNLELEEQLQDLQTTVADLESLNEMNEELQENARETELELREEADMQRSKVAEYQRRIEAMKEAASDSQETIAKFRQLTASLQEKNRDLISQQQSAAVSQDAAADMPTFDFKAKFLETKVQAKAVEVDLYKLRIDQANQHIDYLCSFMPDQFLRRGGDHDCVQVLLLISRMLAKSDLLVNQLKERAEIPETMNREEVLRNNKGEQLAFTNFLIFTMSQLQAILTKYQIALTNCNVALLCKIGTLYPEMSPHETALDYLIDLFRKDQLDETTSLESLMKAIGFFTHLYNVHLSQENVDQTLLMADSVRLVSSATDIVGLEIKKLRVLMQAMQETSDFSILLKDLEGTNADLKTFARMIRRRLPQVEGSDGPTPGPQALVYGGDVQSSLTECCEHLITLVAGLRDLGQGAMKVAGSLADASDKEKRKKQGGKEDAEGIPVARLEEIAERASDLAYGKQDKGPYQSFRESLVRAMVIMSKISQAVQEGEYDSNVPMDKIQPPIARRAIKVKSEICDSEGLGHKLELKDSEIKDLKRQLKLKQEEVSANAVRLGLVEKKLENASRDGEDKVGKVERELAQQHDLLKKKEREFEDTLDHMQSDIDALEREKLELKQRLTQVSKKALFESLTSKTAPSGIAAVVAGAAGGNQGGTSPTSPTGGGVPLGSQVVIKDSPMLVQQIESLKHALCKVKGENVRLKSAEMKRIMDTLPPLHVPKKPTGLASPTGFVALVPSTEEPSEAAPADGGTAAAPKPPVASVDAQMDVTLLARRTRKLLQELHHLSASPKVVDITQRKPGMVPAIDKAMPIHQLVDRMANMQQLKTSIAQLQNEMQALLSSQRPGAQAKTDFSVFPSADFSKVQTEKTGAPRVGKLSIPVSGDQQPCSYSVSLQQSQLRRVHAQLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XL62</accession>
    <name>A0A8B7XL62_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110974305 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110974305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081544.1">
        <property type="nucleotide sequence ID" value="XM_022225852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XL62"/>
    <dbReference type="GeneID" id="110974305"/>
    <dbReference type="KEGG" id="aplc:110974305"/>
    <dbReference type="OMA" id="WTHKENI"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042359">
        <property type="entry name" value="TERB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14014">
        <property type="entry name" value="TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14014:SF0">
        <property type="entry name" value="TELOMERE REPEATS-BINDING BOUQUET FORMATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="980"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1077"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022081544.1"/>
        </source>
    </evidence>
    <sequence length="1093" mass="121828" checksum="F92044E206B420D1" modified="2022-01-19" version="1">MSTVIFRGEMDGWHRDVGSGQNHAAEVKTDLKLLLECLKCHMGDVAVQQDTLLTAAAVCSSSDEAKEFFRECGGINFVLNLLTSTEEDKVKIAALYMLGCACEKNVFSQKRLCTLAIFKFLYCQLIGGKETSDSLKRTSAFLLLCLVTNNGEGQNLARTSHCLEALLKLFRTSYPLAPHTSGLPGQMWMDSSDTDCKKQLDLWTVVTSTLSGCVNNPQNEANQLMCSSVAFATAIDIIGKTRNPTIIRLVSSFLSLTISNNVSNQDKFGLLGGLEAMVNLLHAVVGDLLQQPDQDAAQAAVQLANVFVPCITDCEQNRCRLMDLNLVPLLVQLMSMDFIESDVRLKIIITLGHLTEKCGRSQRQLLESDGLSLLVHLMADNQDEEFNKAAMYLLSSCIDLVTLTLLTAVSCMEDVGLNASDSKNVPKRPRSAEKRNKARAERESAFIPIGKQRAETEGVPDGNKVPSRHKNAEQEQHITTGVVHGDNANSNDRASSCSHRMTESTENKVINELLQQLHEEKSIRQRLEDEKKVLEEREEARARSRGAAKEAALVITKELERQYTEQKLDKTPEDEGEQPEGTKSATPEKQFLSPSMKNVEQRLEALEKSLNDISSVNNQLAEPIIYSRQRDQQVNDQDLGQKCAADGNKMSNLAPVTNIDQDGNVQLPKVKSKQLCDRVNKYIRNLGDGTDSVGKSQKTAGDALKTLCQFSEFRAPTSPVRRRQVPRKIATGTNQHILPSPNVIKLQRCVADLSRRQPRLQCSQYESDVESCLSESTDLSTSADTDMSMTASDMYLMKQAQPPHQMPHATWEHGPAPSLHPMSSARGRANRSYRVNYSWQRGPTVSVPVSRKLSELTNLSVSHHGIGRDSITKASKDVFTFTESENDLSGISSSECSNKSGFHPVPKCPGCAPPINRPLLNSRNFLYTLERSQHTCSEHRKLQRCIKQDLYHRRMAQTSNKGASPEFAKSSRSHLVRNLRSATRNGRSPHSITSAPRNKWASCASRRRRKRQEFSRTEICNLINGVAKKGKHWNCILWAYKFAPGRTAVDLKDKYRRMQAQNYVDVSPRSSSSSHLSSKQRQTQKAIDHTWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XL98</accession>
    <name>A0A8B7XL98_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosylphosphatidylinositol anchor attachment 1 protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080896.1">
        <property type="nucleotide sequence ID" value="XM_022225204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XL98"/>
    <dbReference type="GeneID" id="110973945"/>
    <dbReference type="KEGG" id="aplc:110973945"/>
    <dbReference type="CTD" id="8733"/>
    <dbReference type="OMA" id="MAIALWM"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="525"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080896.1"/>
        </source>
    </evidence>
    <sequence length="651" mass="72447" checksum="35B2A34BEDDAE382" modified="2022-01-19" version="1">MGLMTDPKTQAFLSNFISRFHKAGSLLCYLAGMAYMLALAYPPLNAGTYFSENALLPGLVDREYGDNSYNVEQLAEEYKRAVESIEGLPVRYMETKFTELGLDTFTQNFSIRHPFLQTEVIGNRRVPQVIQGTNVYAILRAPRIAGTEAIVMLVPYRSSKAAQERGDTHYGIGLMLSLAKFFRTKTYWSKDVIFLVVDQEDMGIQAWLEAYQGIPSNYISSSIMQGRSGAIMGAVNLEVGVARVRRLDLVTEGINGHLPNLDLFNLVVRLCSKEGVQASFQGQVDSGNNQRLTREGYEKSVKTMLLNMAHQATGQPRSIHGLFLHYHIEAITIKAAAGQKSGSKSMQMVGRVLEGVIRSINNLLERLHQSFFFYVLPNCDRYVSIGLYMPPFALLMMVPLLNGLALWITSGNISKSAQDQDVGKDKPKTDSESMEDFVPRPFSTIMPLLIGASVTGALLYISPEFFMSRLATAFKLTPEEIVSLGVMGLFVGSIMLPHIIRRKMSSPSDPGQATAEWQLLKSVALIWQAVILSAISMINFSLAFFLSVAMVPISAVIRPSSRTLFRLLNAILLLLISPPILLFLFLAIYNAATSPIVDITELLSVTLQMSKHAMYRSVVDGYLYGNWSYGLATMVVFPNWLMLWLVVWKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XP52</accession>
    <name>A0A8B7XP52_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">1-acyl-sn-glycerol-3-phosphate acyltransferase gamma-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11 12 13" type="primary">LOC110974535</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081945.1">
        <property type="nucleotide sequence ID" value="XM_022226253.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081946.1">
        <property type="nucleotide sequence ID" value="XM_022226254.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081947.1">
        <property type="nucleotide sequence ID" value="XM_022226255.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081948.1">
        <property type="nucleotide sequence ID" value="XM_022226256.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081950.1">
        <property type="nucleotide sequence ID" value="XM_022226258.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081951.1">
        <property type="nucleotide sequence ID" value="XM_022226259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XP52"/>
    <dbReference type="GeneID" id="110974535"/>
    <dbReference type="KEGG" id="aplc:110974535"/>
    <dbReference type="OMA" id="LAGWMIC"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF24">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 3, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="91"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022081945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022081946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022081947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022081948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022081951.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="45153" checksum="BC65CB8303076241" modified="2022-01-19" version="1">MGLASSFKGSPLVQMVLCVTFIISGVLVILMQLAALVVIRPFNKRLYRVIVCNVVYLHWGQLIWLCDHWSGTEVRIFADEEFRKICGKEHCVMIANHRNDVDWLAIWVIADRFGILQQAKCLMKNELKYVPLVGWSFAMLEMIFVKRDFARDKETMINGFRNYITYPLKCMILLFCEGTRFTQEKHTKGLAFAKEKGLKQLKHHLMPRTKGFVVAMEAFDGQVPAVYDLTFGVSQTDSKPTLVNLLRGKKFVFNFHAVRIPIADVPKTEEEQVKFIYNLYEKKDELYEHFLEHDTFTGYDHRSGFVMPKRWGPLIVEVFWLLVLGLPTLYQLLKILTTGSAVATATALGIVVVLYFLIKYMIGATVTAKGSEYGGNKHRNKIQNGNNSTSDGKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQG7</accession>
    <name>A0A8B7XQG7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110974745</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110974745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082271.1">
        <property type="nucleotide sequence ID" value="XM_022226579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQG7"/>
    <dbReference type="GeneID" id="110974745"/>
    <dbReference type="KEGG" id="aplc:110974745"/>
    <dbReference type="OMA" id="WYIQGRD"/>
    <dbReference type="OrthoDB" id="6285995at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031643">
        <property type="entry name" value="DUF4708"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28495:SF1">
        <property type="entry name" value="GENE, 17266-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28495">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC100359752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15813">
        <property type="entry name" value="DUF4708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4708" evidence="2">
        <location>
            <begin position="9"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022082271.1"/>
        </source>
    </evidence>
    <sequence length="750" mass="81751" checksum="5219EA16295BFFCE" modified="2022-01-19" version="1">MASKPTTSSIFFATVPDYKDLCSVTIQVQDSASSFAKRGGTASKYVGSQPQIVKCRELIFTEPGLLASPSLQQEGHIYVVLQQSVWRSGRLQSRCQKMGLVVSKPMQVISPIFQACLAYTIRARLAPLWNKAGNWYIQGRDFLLSSGRVPAVDLQVNVTEVEICLALRPLTVKLPQCSLIDFDVCQPVLDQFFLSTNNVIFEYSIDSKWCFVLPSLKKGKVVSISHNIPSTSPFKTYKEIRRYWKNAYGYRLPESDVGVLYYNIYFPAIGPTLFTYPEFCIRKDEPILQARVDPAPIISAFLTDLRHKLPSVCGSSFQITPKALYTSTGFYPTGKEEDKLPHLNLSSTPPPTSICRIPTRPISLQGFAGDHVLSVPSLTQPASVFGSPTANLLTGTVGEINAAFSIAGRVSFPGAHPVSPTDQHVDSQFATHGHRTLNGPANTTLGAQIAVSPPVRHTAFRPVLPKPIVGDQAGFGLVNTWNGKAYANSAFSEMTSCGFQSTSQCLPVVTALSANQSGNHTVAPAPQRIIPSFKTQRPQTSNYFPASTACVRGEDPSPRIVPSFQSTKKVHLHPKSQLGTSALDTTNKAFPQPRALDAVGLSSPMQAAFDQPKAADPVFVPSFPHRDSSQATREPTAAKKQVQQTLDAVVIKIPSGANHQKYDSGKSTKRKSKDDTTEGPTATKKARVKPKVQEGVNVQLLAINDQLSKVNTITLATWLQDKGIPVKAKEKKSDLMQKVADFIHANSIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRQ0</accession>
    <name>A0A8B7XRQ0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022082651.1">
        <property type="nucleotide sequence ID" value="XM_022226959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRQ0"/>
    <dbReference type="GeneID" id="110974967"/>
    <dbReference type="KEGG" id="aplc:110974967"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016206">
        <property type="term" value="F:catechol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042424">
        <property type="term" value="P:catecholamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000054">
        <property type="entry name" value="Catechol O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082651.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26200" checksum="841E7C198723624C" modified="2022-01-19" version="1">MSVIFLRFLRDLWYWNTVEERVLDFVKKTAAEGDPASVLDALDVYYTDHDVILSVAPEKRLKIEEVVRKAAPKVCLEMGCYVGVSAMAVARHIPLEGRLITTELYTKTAKVAREMIRFAGLEQVITVVNKRADDVIKVLRSEYSVDKLDLVVLDHSKWSYLPDLKALEKGGFLHKGTIIIADDCFWPGVPGYLEYVENDPRYQTERFYSIALPGIMDTVDAMAISTYKGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTR5</accession>
    <name>A0A8B7XTR5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">sulfiredoxin</fullName>
            <ecNumber evidence="2">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110975776</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfiredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022084243.1">
        <property type="nucleotide sequence ID" value="XM_022228551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTR5"/>
    <dbReference type="GeneID" id="110975776"/>
    <dbReference type="KEGG" id="aplc:110975776"/>
    <dbReference type="CTD" id="140809"/>
    <dbReference type="OMA" id="TWIERFI"/>
    <dbReference type="OrthoDB" id="10023328at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1530.10:FF:000001">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="10">
        <location>
            <begin position="84"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022084243.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20330" checksum="F382DDFD23D51287" modified="2022-01-19" version="1">MSVFSYARRTLSISVGVHELLRLALFYGQCGMLMSTEEIKQRHILLKAPQCSAGMATYSSGKTGTIEDPKTVTSIHAGHIEEVHEVPIQHLIRPFPSVLDEDKVQSLMDTIKDPAQRQKVPPVDILWIKGRKGGDYYYSFGGCHRYAAYTRLRMETIPCKIVRSTVSDLRNYLGSSTPDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVK3</accession>
    <name>A0A8B7XVK3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084282.1">
        <property type="nucleotide sequence ID" value="XM_022228590.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975797"/>
    <dbReference type="KEGG" id="aplc:110975797"/>
    <dbReference type="OMA" id="ERYAIAY"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01518">
        <property type="entry name" value="RHOD_YceA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000022">
        <property type="entry name" value="Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022111">
        <property type="entry name" value="Rhodanese_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020936">
        <property type="entry name" value="TrhO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040503">
        <property type="entry name" value="TRHO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057944">
        <property type="entry name" value="TSTD2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE/RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43268:SF6">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12368">
        <property type="entry name" value="Rhodanese_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23949">
        <property type="entry name" value="TSTD2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17773">
        <property type="entry name" value="UPF0176_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="324"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00069711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084282.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58493" checksum="4E1B66E86C127A28" modified="2022-01-19" version="1">MMSGDIPNNQSKHPSKIKKITRKRVFAGFVKSKLIEDECSNDRSVSGQTHRWQCCSKTFTVAAEIHKHVALCHRETVDEAMTSELKGVHHNCRRHNVSNFKRKDIGPCRLPGKLQPGSEGNCSEDGNREDSNCISSEGDEVNGGRPSALVQFQATSSKTKENPKLTGSDRAFPWLPSLEKCHHLDKSEEGQILLYYKYVDIENPSNVADWQRELCQRLQLTGKIRLATEGIXGTVGGSLEATELYIQSVLAHPVFKDMTSLDFKKSSGGAGHFPKGLKVGVHKEIVPMGIDPETLSYRQAGAHLTPSEFHKEIDLHINSETAPCSRDTLFLDCRNFYESKIGQFKSAVTPNIRKFSYWPEYVDRNLDLFREKRVIMYCTGGIRCERGSAYLKTKGVCQQILQLRGGVHKYLEEYPDGHFKGKLFVFDDRYAIHTNNEVVASCFHCDQPWDQYRPCSSAHCHQLVLACPGCSEAGRTACCKLCRDIAARALTQGGKAREECLCTRKRERIPVENGKVCDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW62</accession>
    <name>A0A8B7XW62_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">15-hydroxyprostaglandin dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="3">1.1.1.141</ecNumber>
            <ecNumber evidence="4">1.1.1.232</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eicosanoid/docosanoid dehydrogenase [NAD(+)]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prostaglandin dehydrogenase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110975795</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites. Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78836"/>
            <dbReference type="ChEBI" id="CHEBI:90697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48641"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.232"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>14-hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NAD(+) = 14-oxo-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90866"/>
            <dbReference type="ChEBI" id="CHEBI:90867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z)-eicosatrienoate + NADH + H(+) = (5S,6R,15S)-trihydroxy-(7E,9E,11Z)-eicosatrienoate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:41596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78325"/>
            <dbReference type="ChEBI" id="CHEBI:78329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:41597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>lipoxin A4 + NAD(+) = 15-oxo-(5S,6R)-dihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41572"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67026"/>
            <dbReference type="ChEBI" id="CHEBI:78311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:41573"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostaglandin A1 + NAD(+) = 15-oxo-prostaglandin A1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41263"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57398"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:85072"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41264"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16477"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57397"/>
            <dbReference type="ChEBI" id="CHEBI:57401"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16478"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>prostaglandin E2 + NAD(+) = 15-oxoprostaglandin E2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57400"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
            <dbReference type="EC" id="1.1.1.141"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:11877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>resolvin D1 + NAD(+) = 17-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>resolvin D1 + NAD(+) = 8-oxoresolvin D1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50124"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132079"/>
            <dbReference type="ChEBI" id="CHEBI:132080"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>resolvin D2 + NAD(+) = 16-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:53589"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>resolvin D2 + NAD(+) = 7-oxoresolvin D2 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:133367"/>
            <dbReference type="ChEBI" id="CHEBI:137497"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>resolvin E1 + NAD(+) = 18-oxo-resolvin E1 + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49244"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:91000"/>
            <dbReference type="ChEBI" id="CHEBI:91001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:49245"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.141" evidence="3"/>
    <dbReference type="EC" id="1.1.1.232" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022084275.1">
        <property type="nucleotide sequence ID" value="XM_022228583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XW62"/>
    <dbReference type="GeneID" id="110975795"/>
    <dbReference type="KEGG" id="aplc:110975795"/>
    <dbReference type="OMA" id="QDRHDET"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047034">
        <property type="term" value="F:15-hydroxyicosatetraenoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016404">
        <property type="term" value="F:15-hydroxyprostaglandin dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022084275.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="28975" checksum="7B49E3D35EA184F2" modified="2022-01-19" version="1">MAINIKDKVALLTGSEGLLGPAFGTLLLEKGAKGVVFLGSEKANDINKELVEKFGGERVMLYTCDITDQASMKAGFEEAKARFERVDVVCNCGSSWDEIKWENTVQVSLHGVIHGTRLALEYLEPNGLLVNVTSVAAMTLAPYLPIISACKAAVLAYTKTVAKYDPVAKAQKIRVNVFLPCPMEGDEMSSAVLAEEKVQQHATITLTKLKTKPPNIVASALMMLIDQDRHDETLYVHGELGPIFAADDTDEFRRKYRASTVVKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXK7</accession>
    <name>A0A8B7XXK7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cationic amino acid transporter 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110976211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084987.1">
        <property type="nucleotide sequence ID" value="XM_022229295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXK7"/>
    <dbReference type="GeneID" id="110976211"/>
    <dbReference type="KEGG" id="aplc:110976211"/>
    <dbReference type="OMA" id="SEYMEVE"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF20">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="6">
        <location>
            <begin position="522"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022084987.1"/>
        </source>
    </evidence>
    <sequence length="581" mass="62726" checksum="DA741DA567BFB43B" modified="2022-01-19" version="1">MIGVGSMIGSGVFLLPGQLVGVVAGPISLLAFFISGLIALLAGLCCTECALQIPETGAAYAFAYATLGEMVAFLIGWGGVATRILGVALIAQVWSGYLDEATGGYIQNATVKFVLGGEEWDAPLLSSYPDFVAGLVILASNALVSFGTNVFSKVNNVFVLSTLLTLTFVFIVAMIHANFFYLVEHGFAPRGVGLDEVVASVFTAYLGYAGFETIALCAEEAKDQTKDLLMGLLAAVAISMLVYLAGSLSITVLAEYSNIDLKSPFEAVFDELDGLHWMKYIVAISALCSVTGGALNFAYSSTRFIYPMSRDGLLPAMLSKTSETTKTPLLANFLGACLSLVLGVLIDIKFLIQVPSMLFTLETVGVIFAAVILRYNPTLQSEYMEVESKDESCGTGGSSVPHVNRHHSNLEMKGLLDQMQETFTGDNNAGSDPPSPPSLIKKASTVLFQWIRNHPTRSVILSLCLHITFEFLFVGLLTFTLEDFSQASDSSLVLWIVICGVLCLIACFPLLLLPQYRDELPFKVPLMPFLPLIGLLSTTILLLHFDFLAFIQVLVWTCLGILVYFTYGMKHSVEGARQDGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXL1</accession>
    <name>A0A8B7XXL1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110975952</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084531.1">
        <property type="nucleotide sequence ID" value="XM_022228839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXL1"/>
    <dbReference type="GeneID" id="110975952"/>
    <dbReference type="KEGG" id="aplc:110975952"/>
    <dbReference type="OMA" id="RTERQEM"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022084531.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22420" checksum="C2107414DE683C6F" modified="2022-01-19" version="1">MPKGLSPRGGIDAKNDSCDQAILDFSFKDILLTDDILDVEPRVAKNSKLEKTAEGLVRTQTVKLNNNGMTEMAGLDVTLEKVVESPEELTWLDLSFNDIAKIDPLLLKYTKLKVLYLHGNNITSINEVDKLAGLPSLISLTLHGNPVEDQKGYRQSLVAKLPRLKKVDFSCITKSDRENAATWERDYGKRRPPKKPKEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXY5</accession>
    <name>A0A8B7XXY5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Growth hormone secretagogue receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110976619</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085753.1">
        <property type="nucleotide sequence ID" value="XM_022230061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXY5"/>
    <dbReference type="GeneID" id="110976619"/>
    <dbReference type="KEGG" id="aplc:110976619"/>
    <dbReference type="OrthoDB" id="10017003at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022085753.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42185" checksum="CB4C72216BBD80F6" modified="2022-01-19" version="1">MGSDISSVECSAHKNISEAEASRWLYTPTDVTFITIGVPIVLCIGVGINLTFLFVLIRVPTMRTNTNVFLTNLALADLLFLTLFATIVLWRYAFSPVVFSFQFVNSAGCTLFHLLLETGYYSSVASVTMVTHERYLALCNPLKHLQMRGSQRISKIVLTCWLVGLMLACITIPIEALFHKWCVQWPNGNEYQDLPSTVVHCVPVKPNVIFYSPLLQSGPWFLVMVCNLYMCVKLVQTLVKQVATESTCRFGRSRRTQQRKRQVAVMIIVNGAVFFLCQIPFHAFNIIKWICLIAEIPSPVDIAPRSDQYWLVNFFYLFNIIINPFIYGALNAQYRAAFLEAFGCRCRPMNRRNMPHPPAKEDLDQREDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZ78</accession>
    <name>A0A8B7XZ78_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110976263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085071.1">
        <property type="nucleotide sequence ID" value="XM_022229379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZ78"/>
    <dbReference type="GeneID" id="110976263"/>
    <dbReference type="KEGG" id="aplc:110976263"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF44">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="10">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="87"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="181"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="576"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="678"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="509"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="619"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022085071.1"/>
        </source>
    </evidence>
    <sequence length="715" mass="79328" checksum="DF80C5BBDE0D3503" modified="2022-01-19" version="1">MFAGTTGKDMPGFRGMRYSKFRHVYGNPYRREKCYNNIPITKNSHDAFFCAVNPKFVAVVLESQGGGAFLVIPIDKYGRQDALNNRLTGHKGPVLDIKWNPFNDNEIASCSDDGTAKVWYIPDDSVPTENNATLLADLVKHTRRVIQIEWHPTASGILLSASQDNKIIIWDVQQEKVFKIIDCHRDRINCVAWSWVGDLLATTSKDKKIRIIDARSGEVLKIGEGHTGTKSSKVAFAGNTDYLVTTGTARSSTRQIAVWKQDDLSKPMEMMDIDSGTGVQLLFYDPDSRVAFVGGKGDGSIRYFEISPGEEPCIFRLNEFITSMPQCGMGIMPKRGLDRKQCELVRFYKLHVSKGVCEPVSMIVPRKSEAFQEDIYPPTPSNEPALTAQSWIAGMDSPPKMVRLEEHGTSSVASTPVRPSLRESVIQTKAKAPSKSEDAGRGLSSRPTKEEGMDSSYTPSWSSSGTRVSSTRRIELSSPSMRREEVEKENVVPAESSSLHSAPPPAPEPEVSTLSEVSSISSSHSGGSEGHPSIASRMAMFEDGSKRGWRRTGSVDSGIPSSSTKIILRDTIREDDSSVFVLKDSGDRSPQRKSPRRTFSTESKEVIRIEREPERERGTSMSLEDQMIRSNGDGSETAGKASQSASDVNTRRDFMTSKDLGMDQLSPGEEGTMLRKAYLRQQEEIKQLKSQLMLKDQRIRQLEREIEDLTLSSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZY0</accession>
    <name>A0A8B7XZY0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division control protein 45 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110976657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085822.1">
        <property type="nucleotide sequence ID" value="XM_022230130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZY0"/>
    <dbReference type="GeneID" id="110976657"/>
    <dbReference type="KEGG" id="aplc:110976657"/>
    <dbReference type="CTD" id="8318"/>
    <dbReference type="OMA" id="EDCFMEA"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022085822.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="65474" checksum="514D1DB87B0365DB" modified="2022-01-19" version="1">MFITDIRKDFYEKVLHKRVLVLVSFDVDAICACKILQALFHCDSVQYTLVPVAGKMDWERAFSEHAEQLEFVVMINCGATLDILETLQPEENVTFFVCDSHRPMDLVNVYNDTQVKLLMSPEESIPKYEDIFRDEESDNEDDSGHDSDGSEPNGKRRRFDEDALERRMERRRQRREWDERRHQLLFDYEEFSGYGQSAAMIMYDLAWKMSKDTNDLLWWAIVGLTDQLLSKKVDRETYVLEATELNRHVARHNHRGEEDDDSVSINSMRISFNSELQLALYRHWSLFESLRHSSYTACNLKLWTLKGFKRLHEFLADMGVPLSECKQKFSAMDMGLKDNVTDWLVTSARKFGLEQISLSSFHAQYGFKNKFCAFDVAYAVNALLESVETENTPEGCFLEALDCLSRSNIDKLLHGLELSKRQFRATVNQVQSLLDMSQVISAGSFLYAFIQEGTPDTKYFSRPNCLGMLARFTLEAYVKMSKNRKARTLPLVMTAPLNLETGTLLVVGIPPLPELEQSSKNFFGRAFEQAGKKTGSRILHDNFDSSVIEMKNEDRSKFFDALISLLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y036</accession>
    <name>A0A8B7Y036_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tudor domain-containing protein 5-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110976416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085356.1">
        <property type="nucleotide sequence ID" value="XM_022229664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976416"/>
    <dbReference type="KEGG" id="aplc:110976416"/>
    <dbReference type="OrthoDB" id="10052065at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08824">
        <property type="entry name" value="LOTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09972">
        <property type="entry name" value="LOTUS_TDRD_OSKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF76">
        <property type="entry name" value="FI20010P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12872">
        <property type="entry name" value="OST-HTH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="HTH OST-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="7">
        <location>
            <begin position="147"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="7">
        <location>
            <begin position="354"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="7">
        <location>
            <begin position="462"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="6">
        <location>
            <begin position="628"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="811"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1076"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1277"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1096"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1296"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022085356.1"/>
        </source>
    </evidence>
    <sequence length="1308" mass="145968" checksum="1C1C09EF2B257B1E" modified="2022-01-19" version="1">MSDQAKLKESVKKSIRGLVGSAPLGLTPEEVALDYESFEGRPLPFRQLGYNTCQDFLQDIPDTVRPCWERGQLIVRVVEGESTRHIHSLVSRQKVDVLKCLKKRRGAARAGARTLLTDANAPGRPAGGIALNTRPNTRGPPALSPSVSAYLRNQIKSLLIAHPNGVLNVHFDRLFAEKYGHTISFKKLGFESLAHMCQSMPDFVTLERLRGDEFRIYEKSNHPAVNEPTSDTVSSSTQRTRANKTEHVQRDNVDSSLPDSRKAPLASCSFEDDENFKQKSASNVPRPSNATSHSSTMSKNAGYANSTEQPGRLTEPQSAQRTRPQVTKSSNASQDVSKDVNASSEDGSLTSELFDTKFLQQIRQILERHPEGLWAAYLPDEYKKKYKKALPMMSLGYFSVTELMAAMPEVVAVEREQKQGDWKLYDVRTYKPKTVESAKSKASSSDQNVKANKKLNPNPTQGFQDLKDKVRQLLEKNPEGILLKNLAFYYQRMFGLSFPVDELGFRDVESLIMMMPDTATLVYKGYGRLLVMLVEEMPVDSLNIGDEKLSRLSIPADSVGWGFSYSYCEYPPIQDYIEVYVATVFTPHRLSIQLKDKLRNDALDDLMDELESIYSYPEGNKYEFPECMIAVGQVCCALYLSDNNWHRAVITGIPKVDFLEVLYVDYGTVATVSRSSLRLLKSCFLKLPIQAYNARLAFIAPSEDKWTMKARDRLLAMTAGKPLIALITEIQNDELYLLLSDTTTEEDIHINDALVEEGLAVFARTQDDLDQLLPPPLEGDVPQPDLAMLTLEDVTEFDENASDDQRELLDMTQEQEESPLAPEDGAEVDVPLPDGGSNPPSEDKSRDLPPLEAIADEAPWIVKRIDFHDGYQVHLINHDSDACLTVVEVADLMCGEDESEPEDILYQQVDNLGVEIPLLTAVEKESPRLFEELRSFDLLDDSEDFILMMPFTSAMLLLSSCSSVRMDTVQQLQEIAENFGVFGDLVGSDIDESAKDELDLSLDVEELNMTLSALQFRRKRILGDMMVSHDSNGVDHLSYIERKIEEISQKLEATKSHMQQQEVADKMVSLTNSALPHREPEQSNSPVTPNRPLSVVSYSDGSTESQGRLVQPVQPLPREEEKSSLASQPPPVNVQQSDQRDTLCLTQAAVGQSQSLHQPLFNQMAPSTQPGYQFAACQNTPNPGFPNPQATRLLAPSPSEPFFAPHQLTHSQYPLMGGANQGYQQHLRSGDFVPLPQPVNPNPWLGPPPQTHVMSQYPLPQQIAIAQFVPIPVSDPPRPFIVNPQRYGPGPPGPGMPRQMQEGQGSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2V4</accession>
    <name>A0A8B7Y2V4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-seryl-tRNA(Sec) kinase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110977115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086645.1">
        <property type="nucleotide sequence ID" value="XM_022230953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2V4"/>
    <dbReference type="GeneID" id="110977115"/>
    <dbReference type="KEGG" id="aplc:110977115"/>
    <dbReference type="CTD" id="118672"/>
    <dbReference type="OMA" id="FHYEREN"/>
    <dbReference type="OrthoDB" id="9972657at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013641">
        <property type="entry name" value="KTI12/PSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052648">
        <property type="entry name" value="Ser-tRNA(Sec)_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20873:SF0">
        <property type="entry name" value="L-SERYL-TRNA(SEC) KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08433">
        <property type="entry name" value="KTI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086645.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44480" checksum="FA2CC4A46AD14C6C" modified="2022-01-19" version="1">MEQRLRTDLKVCLALLCGLPGAGKTSLAVALRLKKMGRHLVLNSSPAVDVGHDAVHQCPTEAVLHLCYDDVIPRQLDLESEGGQSSCLDETANQSLSSVSLWKAHRQEIIRCVDCILARLKTGKVLDITAALDEQELSHFRREVWSKVLTSMQDQIVSLKQPQPTSWAEGKQVQPASSVVLLIDDNMFYRSMRYEYYQLARKYNTSFCQVYLQCNTEVALARNSQRRNVVPEETVRKMANRMEVPDRQVASWEKHTLCIEAKGLENEATLSTVWALIAEALLDPVLPMEVENAEEREASRVVCAASAIHQADQSLRRCVAEAVTAAKEGGSLSKAELRNLGSKLNDVRQTVLQKIRTREIWPPPLVAAAVDHPDNAERCSDFYAFIRNLFLKEQQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3P5</accession>
    <name>A0A8B7Y3P5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Large neutral amino acids transporter small subunit 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110977040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086501.1">
        <property type="nucleotide sequence ID" value="XM_022230809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3P5"/>
    <dbReference type="GeneID" id="110977040"/>
    <dbReference type="KEGG" id="aplc:110977040"/>
    <dbReference type="OMA" id="FNFVTWT"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022086501.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="52375" checksum="EA10535C47B16D23" modified="2022-01-19" version="1">MGKIQADQSSMGSQETAGSSRVELKRTISLFSGVCINLGIIIGSGIFVSPKGVLSGAGSVGLTLVLWVVCGVFSLLGALCYAEVGTTWPSSGGAYAYLKAIYGDLVAFLLIWIAVLMAQPSAFAVVALTFGNYCLQPLYPDPSCPPPQIMPQLLGTLVILLLGMTNVLSTRLSTFVQNFFTVCKVVALLIIIVAGIVQLIQGETRNFENAFEGSTFSGLGNALYSGLFSYAGWYSLNIVAEELKDPNKNLPRAIYITVFSVTIIYTFANVAYFTAMTPQELLTSNAVAVTFGSKVLGQFAVIMPIAVALSTFGSVNGNMITCSRIFYVGAREGHLPSLLSMIHIKFLTPLPSVVVTVILSIIYTFSNDIYTLINYFNFVTWTSSGAVVAGMIWVRYKEPDKPRPFKVNIIIAVLFVLASIFLVVIGTIDSPIDTAIGVGITLTGIPVYFLLVYPKRLPRWLTGIQDSVTAWFQRLLLVVKEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4D0</accession>
    <name>A0A8B7Y4D0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21 22" type="primary">LOC110977857</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Endomembrane system</location>
            <topology evidence="13">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022088041.1">
        <property type="nucleotide sequence ID" value="XM_022232349.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088043.1">
        <property type="nucleotide sequence ID" value="XM_022232351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088044.1">
        <property type="nucleotide sequence ID" value="XM_022232352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4D0"/>
    <dbReference type="GeneID" id="110977857"/>
    <dbReference type="KEGG" id="aplc:110977857"/>
    <dbReference type="OMA" id="ECYLIAF"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02123">
        <property type="entry name" value="PA_C_RZF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16796">
        <property type="entry name" value="RING-H2_RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000824">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044744">
        <property type="entry name" value="ZNRF4/RNF13/RNF167_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665504" description="RING-type E3 ubiquitin transferase" evidence="17">
        <location>
            <begin position="31"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="237"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="282"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022088041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022088043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022088044.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="48426" checksum="1F0CF5906D4E2761" modified="2022-01-19" version="1">MECGPHVKSALWCLWSLAAITVMLPCAVMGDVIVTTLKNVSYTFSSMPANFGERLPMMGLQGKLVVAVPLNGCSRLQPPPMVNASGVITYNYFALIKRGECNFDLKVYNAQEVGYAGAIVFNIDHDNGVLAMNGDEYGQDVDIPSVFVGASSGASLKKYNYTTGSKLVLNSDFTFSYNMYLIPFISIVGICFTLMLCFMVAKYVRDRRRLKRSRLSRTNLKKIPVKKFVKGDEYEVCAICLDDYEDGDKLRILPCNHAFHCKCVDPWLTNNRRTCPVCKRKVVPSGEQDSDDSDSDEDSTASPTEHTPLLASSGSGHPVGARGRAAGGGSESSSVASSPELNGAWGGEERSAPAPAGVTLVDASTAMTENDSDSNDDTIDGNLLGRSPINDLPHSVDIVTPTLHAVSSDLLETDVNQDVVDNGDNIPTVLVVSEHADPLAEKDSANFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4Q4</accession>
    <name>A0A8B7Y4Q4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ankyrin repeat domain-containing protein 13C-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110977457</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087310.1">
        <property type="nucleotide sequence ID" value="XM_022231618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4Q4"/>
    <dbReference type="GeneID" id="110977457"/>
    <dbReference type="KEGG" id="aplc:110977457"/>
    <dbReference type="CTD" id="81573"/>
    <dbReference type="OMA" id="YPMHQSV"/>
    <dbReference type="OrthoDB" id="1585644at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000302">
        <property type="entry name" value="Ankyrin repeat containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021832">
        <property type="entry name" value="ANKRD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055285">
        <property type="entry name" value="ANKRD13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12447:SF25">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 13C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11904">
        <property type="entry name" value="ANKRD13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Ankyrin repeat" evidence="9">
        <location>
            <begin position="158"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022087310.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="51461" checksum="6379378AE414A6B9" modified="2022-01-19" version="1">MASLSLREMLADYPLHESVFNNDLKRLSALLRTRDVSEKDVHGNTALHLAAMLGHKECIHLLLTHDAPVRLKNALGWNSLAEAVSYGDRPTITTLLRKLKQQSRESLEAKRPQLIQALEDLGDFYMEVRWDFQSWVPLVSRMLPSDTCRILKRGTRVRMDTTLVDFNDMQWQRGNNTFLFNGDAKPDNSLVILDNDNKLFQRVRYQHYKIRKETEKELEEEVDILMSSDVVTMTLSTKPITFTRAQSGWLFREKKCEMIGNYYAHVYTINNVIVETRKRRGHLSEEDVQKNKAALESLSKGRALPANLQPQYRKSLPAPPATDIRWSEYIKGRPSRAHLGRPEVCKESKKVFKATVAMSEDFPMDLPDLLNILEVLTPMRHFQKLRDFVSMKMPPGFPIKIDVPVLPTITARVTFQDFQYRDNILPSLFKIPRDYTLDSSRCPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y565</accession>
    <name>A0A8B7Y565_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110977552</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022087475.1">
        <property type="nucleotide sequence ID" value="XM_022231783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y565"/>
    <dbReference type="GeneID" id="110977552"/>
    <dbReference type="KEGG" id="aplc:110977552"/>
    <dbReference type="CTD" id="5979"/>
    <dbReference type="OMA" id="QICKGMQ"/>
    <dbReference type="OrthoDB" id="5984265at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000190">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000234">
        <property type="entry name" value="Proto-oncogene tyrosine-protein kinase receptor Ret"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055162">
        <property type="entry name" value="RET_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF617">
        <property type="entry name" value="RET ONCOGENE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22540">
        <property type="entry name" value="RET_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="768"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="802"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022087475.1"/>
        </source>
    </evidence>
    <sequence length="1180" mass="131182" checksum="71AC32397E01B950" modified="2022-01-19" version="1">MVRLKHAICSIARSAFYTLRNTRTIMGFYPAAGPTLEYILLILMTRGITVSAEAVYFTMDTYTTTIAQDFPDHKAIARVYTRVISANASVVYALEVVQTSHTHQARTFQSPADDGEARHLFTIDQKTGIISLQQSTVTRGNLTGWNFTLQISAWTQRERLAISDLGSEPLARALVMVNMVASPLRCACFGEADYSFRLRVNAANGAFGALSFPPRCSHANGASFEYAFLPERSSDGLYIDNRTSELVLIRRSGAQLQSRNLTVKCTVEDAASDGDQKSDTRQIMIHVPDYNVSVRQNRSKGDRVERIWTHDPRVKNLHTIAVSLAGEHKDAYGFIGATNAPPSVDLAQSGARFIGEIIFNQTFSRCYEARHILTLVLLDGATRQAAAAQGVTITVEINLLAERNVLNLTLHRNASLYTRVAVLEFPSCPSMILEPPTSFLQDGGLLRLNRSSLFVFVGDTTPLTNENLTTYAAVAQRQVAWGGDRLATEMVLHIDIIGERKPDFRPECDLPQFTATCSRHNSPGKCVNSCGIGAPDGRCKWRQQKGRAHTTNFSTCSPDLNTCPDAVCDSLELFYPRLCPQDCIVTTEPNYAHMMTLNDNRRGIRSAIGPCSCELDGQRCICDNFLDHPVQRQTTQDLPPVDHTTVGLVSYPLLTTVSPSRLFSKPDDGSAGDDKCTFCDTLIAVMVASLVLGVLALLVYTRVSRGSPLRRLFSGRNYKPPAVIDGSDSRLNSVLSECSDDGLHLSKGSMTRLKTEFDPKWEFPRQNLVLDKVLGEGEFGCVVRAQALSIRGHTGYTTVAVKMLKGSYSADDLQDLITEMNLLKDLNHPNVVKLLGASTQRGPLYVIVEYCQHGCLRDFLRQNRQAAAYQQDDSSLHDYDKIQDEGNRSHIEWNNRNLLSFAWQICKGMQYLAMLKLVHRDLAARNILVAEGMVVKVSDFGLARDLYESGTYVKRSKSRIPMKWMAPESLFDNIYTTKTDVWSFGVLFWEILTMGAMPYPGIMSHKLCQMVRQGHRLERPDGCAEELYSVMQQCWHSDPNDRPDFDMLGTMLERIMEKDADYLDLSCSPYGDCSDEEASASGSGDVKSSSSVPLLQIPTSDSPGILPLSVSLKKDHQLMTDDRHLKEIIVEEETNVDSGPLYGDMDPCRLYSNINNNFIADHLCKTVSEPNLSSTDVFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y686</accession>
    <name>A0A8B7Y686_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat and SOCS box protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977861</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088057.1">
        <property type="nucleotide sequence ID" value="XM_022232365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y686"/>
    <dbReference type="GeneID" id="110977861"/>
    <dbReference type="KEGG" id="aplc:110977861"/>
    <dbReference type="OMA" id="KKGTWMK"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF61">
        <property type="entry name" value="ANKYRIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="227"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="4">
        <location>
            <begin position="375"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022088057.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="49430" checksum="F5E04F08F9610A11" modified="2022-01-19" version="1">MGGLSTRIRRPVPTAVSPISDPIGYICSCILKRDYRRCKRFLKKGTWMKVVQQQAERTRNGEPMDLRIMDLPLHLMFAISQNGMYDRTFLRFLRLLLNYGYDPDIPDEKGVVALHAALMRVNFFSALASVRLLRRREVYTTKFVLALCQAGAHVNVHEDRGERTPLHVAAKCNLVHCVKILLDYGAEIEALDAEDKTALCLAAESAALESLECLLDHGACVNTCSLRRQTPLHRAVDALPTYNAERCVHLLLDEGADPNAQDINGNTPLHLATRSRAEGSIIHQLLLYEADASIQNALHHSALYEYLIAYSLPEPHQLASQLTLEHLESYPGFLALLESTPRSPRMIRNKEGRILPMLTEARLKPLFEQFDVLDEPQSLQSLCRQTIRLAVGIAPLVYLKNMVKCLGLPPRLEEYVSSARYRQAMRAPGLMFRLRLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y766</accession>
    <name>A0A8B7Y766_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cholecystokinin receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110977945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088185.1">
        <property type="nucleotide sequence ID" value="XM_022232493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y766"/>
    <dbReference type="GeneID" id="110977945"/>
    <dbReference type="KEGG" id="aplc:110977945"/>
    <dbReference type="OMA" id="FCYSHIT"/>
    <dbReference type="OrthoDB" id="6269383at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="22"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022088185.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="38971" checksum="213D50A68906534D" modified="2022-01-19" version="1">MAETVLALRIIKTIIGLLGIFDNGLVILVIARVKFMHSMTNAFICHQAVIDLVGSLLLLLGSNISDPDPFPESTAGEVLCRLWSGDALLWLFFVVSTFNLLGLTLERYFAIVYPLRYLAVFGRRTAAGIMVATWGIGIVLKSYSFLIYTVVDGVCKFQRISVSHFMGPLLICLQYFLPAGVMFFCYIHITVSLKRSAMRVIPAPAPITKPQSDTDDRAPSKPSQCQAAAGLVANDPQNALYRARRNTFKTLVIVFVVFLVCWSPSQITFFMFNLGWFKLEFTSPLNVFSTTMVAANCCINPIIYSFQYNQFQRGVKQLFLGEAVVQNSSRTSESKRQAPRNHATNSTANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y783</accession>
    <name>A0A8B7Y783_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="10">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110977958</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022088200.1">
        <property type="nucleotide sequence ID" value="XM_022232508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y783"/>
    <dbReference type="GeneID" id="110977958"/>
    <dbReference type="KEGG" id="aplc:110977958"/>
    <dbReference type="CTD" id="29922"/>
    <dbReference type="OMA" id="VCMCLEI"/>
    <dbReference type="OrthoDB" id="270127at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04412">
        <property type="entry name" value="NDPk7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000004">
        <property type="entry name" value="Nucleoside diphosphate kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000010">
        <property type="entry name" value="Nucleoside diphosphate kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006602">
        <property type="entry name" value="DM10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057579">
        <property type="entry name" value="DM10_NDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011410">
        <property type="entry name" value="NDPK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037993">
        <property type="entry name" value="NDPk7B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43109:SF2">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25364">
        <property type="entry name" value="PH_NDK7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036503">
        <property type="entry name" value="NDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00676">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51336">
        <property type="entry name" value="DM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DM10" evidence="11">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="6 8">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" description="ATP" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand/>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" description="ATP" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand/>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" description="ATP" evidence="7">
        <location>
            <position position="193"/>
        </location>
        <ligand/>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" description="ATP" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand/>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036503-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036503-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022088200.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="42483" checksum="310D2ABF17B71D70" modified="2022-01-19" version="1">MSQPERFAFIAEWYDENAAIIRSYQLLFYTSDNTVEMYDIKNRRIFLKRSKVDNVRFEDLYIGGTINVHSRQLNLVEYADEFTKKQLSSKKEKTLAMIKPDAVSKFGAIIDMIYAGGFLIANAKMTQMTRQDAEEFYQEHVQRPFFDKLVRFMASGPIVVMELMGNNAVTEWRRLLGPTDSSMARSEAPNSVRAKFGTDQTMNACHGSDAVQTGQRETNFFFGADRKWKNTAKLSGTTCCVIKPSAILEGKAGKIMMAIVEAGFEVSALQIFHMEKANAEEFFEVYKGVVNEYGDMVQELCSGPCFALEITGKGEQTAEAFREFVGPADPEIARNLRPKTLRAIFGHNKIKNAVHCTDLPEDCPLEVAYFFQILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8L8</accession>
    <name>A0A8B7Y8L8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110978671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022089573.1">
        <property type="nucleotide sequence ID" value="XM_022233881.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089652.1">
        <property type="nucleotide sequence ID" value="XM_022233960.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978671"/>
    <dbReference type="KEGG" id="aplc:110978671"/>
    <dbReference type="OMA" id="CRDIRHH"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010256">
        <property type="term" value="P:endomembrane system organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000007">
        <property type="entry name" value="Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="6">
        <location>
            <begin position="761"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1370"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1504"/>
            <end position="1544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1797"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1822"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="277"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1370"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1513"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1524"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1851"/>
            <end position="1872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022089573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022089652.1"/>
        </source>
    </evidence>
    <sequence length="1933" mass="213656" checksum="6AAF461553D3FB7B" modified="2022-01-19" version="1">MATMVVAPKIQPPTNGVYIVQGEMLLVSTAMRRSSRWTSHLPQEEEQDPLLGSFSRLKEILNSISDIADIEPNVFLCPFLDVIRSEDTTGPITGFALSSINKFLSYGMLDTSVEGATSGIENIADAVTHARFVGTDPGSDEVVLMKILQVLRTLLLTPVGAHLSNESVCEIMQSCFRICFEMRLSELLRRSAEHTLVDMVQLLFSRLPQFKEEKLSGMRKLKMRPGGITDGSRRRKSRPSPKVRAKKDRLATTPTDEPSMQSGGAASPPTSNTNALGPTVTAPVTATSPGAASATMSAVTTVTPGTATTASSEASQSQVNLPSTLDVPSEADEQALPPSPSLDSGVDMKDSLSAVTPSESDVTPTQGQVISMQGEQQEEPTENKKGDETDQILDVERSDSLVDGTEDTESITEHSDSASMQDSEYVNPQGVRFTPHHRHKDGSGPIIPYGLPCVRELMRFLISLINPYDRHNTDLMMHMGLNLLTIALETGCDHISHFSALLSLIKDDMCKNLLALLQADRLSLFAASLRVCFMLFESMRTHLKFQLEMFLHKLMEIIISESVRIPYEQREMALDSIVQLWRLPCMVTELYLNYDCDIYCSNLFEDLTKLLSKNAFPVSGSLFTTHLLSLEALLAVVDSIETNCHHRILSSMVAAQGHASPPDRDKAGESAVTIRVQDISGKEDGDKGKERGGKDEDGARQVGMGVTPPTTGYAMAQVMSANRDKEIDASKLKASEDFIEGSPNRRVSRFPPSANLPSLEQLMQIKKKKKMIQAGTEQFNLKPSKGIAFLIEQGILHTPLDPHEVAIFFKENPRLDKKMIGEYLSRKKNEKVLEAFLKLFVFEGTRIDEALRMYLEAFRLPGEAPVIQHLMEHFSAYWHNTNHQPYANSDAAFTLAYAVIMLNVDQHNHNAKKQNIPMNVEQFKKNLSKVNGGSDFDQSMLEEVFNAIKSEEIVMPAEQTGLVRDNYLWRVLLKRGASQEGTFLHAQCGELDREMFLLAWGPTVAALSFVFDKGMDDTITQKAIAGFRKCAMISAHYGLTDVFDNLVISLCKFTTLLSSMETPENLPIAFGSNAKAHLAAKTVFGLAHRHGDILAEGWKNLLDCMLQLYRAKLLPIEMVEVQDFVDPSGRVSLIREEMQPVKSDSSLLGSFYSYFTTAETSTQKGPTNEDKEAIEQARSCIEDCHPEHLITESKFLRQESLQELMKALTFASQGPQAADSLGMQYEEEAAVFNFELLIRVVLENRDRVGTLWQGICDHLYSLIVSQSEYSQLVERAVVGILRLAIRLLRKEDIAAQVLTSLRMLLLMKKSVLQRVCRQVAYGLHELLRTNAANIHSSQDWYTLFALLECVGAGAVPPSVHMVDGKRNLEISDTGTQSDSEMSTGSISGASDQGYTSDSELFKHRQPHRSSSEPDVSTMTDDRVIVVNNDSTVRHTHNHSKGVSKPQNQFEIALDQTLSHHDTKALMKCCESLAFLVRDAAHVTPANFESCVHAIRSFVEATVNGGKLRHDRQKKPEPTKDKKNSRMSRNQRNKKGMPKISSVPEKISQMADGADDGEDDGPPGGYHSLSIQLLDLMHTLHTRAASIFSSWAEEEKKGGSQMTIDAGASALWVKCWCPLLQGIARLCCDIRRQVRMQALTYLQRALLVHDLQTLSAVEWESCFNKVLFPLLAKLLDQIHPQDPVGLEETRMRAATLLCKVFLQHLTPLLSLSTFTALWLTILDFMDKYMHADKSDLLYEAIPESLKNMLLVMDTAGVFQDAAGSERGQNCQLWVFTWERIDCFLPGLKNEVFKPHEPVVSKEPAPSMAPTPDDIVRDGSPIEEEQVTVSAKPEEASPKPSTQDATPTKDALPTVGTAATPTTTPSTIETNPVTSQPNIILQPPLPYLAPLPGAQEAKPGSSVPFLLNPAILKGSPIPIVAPILPQPESSTTGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y993</accession>
    <name>A0A8B7Y993_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Xaa-Pro aminopeptidase 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110978832</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089809.1">
        <property type="nucleotide sequence ID" value="XM_022234117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y993"/>
    <dbReference type="GeneID" id="110978832"/>
    <dbReference type="KEGG" id="aplc:110978832"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000009">
        <property type="entry name" value="xaa-Pro aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000003">
        <property type="entry name" value="Xaa-pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF18">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034510126" evidence="5">
        <location>
            <begin position="22"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="404"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="640"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022089809.1"/>
        </source>
    </evidence>
    <sequence length="737" mass="81479" checksum="C9421B85A0DC0E8E" modified="2022-01-19" version="1">MRERYLLVCWIGLSIGLLCESASPIAGGSGGGAERERGGRVRRQSGEDVRDCTANPPYLPDTVTDTTQRVSDLRAQMASNGIAAYIIPSEDAHGSEYVASRDTRRAFISGLLGSAGLAVVTASEAKLWTDGRYFLQAEKEMDCQWDLMKIGATFDDPSPEEWLAQTLSDGDQIGFDPALMSVSDYEYYTAELKKQQPAKTITMKSIPNNLIDAIWSDQPPYNPDTVITILDAAKYTGETWQQKVIDGAPGQNSTRQQLQMVKGETIDALVITKLDEIAWLFNLRGDDVPYNPMFVSYAIVTKTDTRLYLYNSTSTDRVPAAVKTHLNVNANGLSCISDPCVLVKDYNDFFADLQSLNRTLAGKIWISDRASYAVYESISAENRYVAASPLLLMKAVKSDKEAQGMEDAHAMDSIALCNLGAWMQKTVDSLEDPMTGDIKVISEQIVMQKCVDERAKFASNRGLSFGTIAGMGPHGAIIHYTSTPETDVPVTKAGTFLLDSGGQYLEGTCDITRTFHFGTPTPFMKEAYTRVLLGSIDLAMAVFRTGIYGRDIDSIARNQLWSGGLEYNHGTGHGIGHFLNVHEGPARIRVGVREGEKPLDLNMFQSDEPGYYEDGSFGIRIENIVRTVPADVEHDFGGHQYMTFKMISLVPLEPNLIDFSMFNNKQLEYYNNYNKRVRDEIGPRSELTEAGKAWMMSKTEPVEYTFKLGTGNSGQRTTPSLVAILMTLLLGTLYSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9R3</accession>
    <name>A0A8B7Y9R3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter 12-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110978934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022089978.1">
        <property type="nucleotide sequence ID" value="XM_022234286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9R3"/>
    <dbReference type="GeneID" id="110978934"/>
    <dbReference type="KEGG" id="aplc:110978934"/>
    <dbReference type="OMA" id="MCANCSL"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="24"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022089978.1"/>
        </source>
    </evidence>
    <sequence length="609" mass="65106" checksum="90114EFA5FD96573" modified="2022-01-19" version="1">MDGRGARKTMKRADPPEPPDGGWAWVVLAGAFLSQALTYGYYGAVAVYVPVWIDFFDSSATESSLIVSLSSFFMGFLSVIAGVLITRFSVRSVWVIGGVLASLGLLISALATGTIYLTLSMSLITALGFSMCANCSLVALTIYFKKRRTVAVGLASSGFAAGQVALTPLLDYLIDQYGWRGSMVITAGILLHATACGALVRPLSSKAGKRTLKLQVDSETKSANEETTNIGGMSQQVNEEGDGFVEAQLRTTEDFAETDSRDLSNDDVGRVSFDDKEILWQKNDNSNKKITPKPKPSVGVADVSAKADDATHDPYFLEDSRGTVSPKTNGEISTTLQTDSSPLSVSRWRLGLSKFRTFMLERYGLSGLFRNRNFVLTIPVVIAHGCGWASVVFHLDARAESVDLQSSEGATLLTLMGVGAFIGSVSHGWFIDKGYISPVIAYILAILGNTVTSFILPPLVTFGPLAATCVFFGFSTGVAEPLIFAILRVLVQPSEVAGATSILLVCWGTGEIIGATIAGWIYDNLASYNNAYFVSGSVYTLAATLAAVIYCLEKRKSKGQKGEADKATIEAQRAPQNPGKKSGDRLDENLEDGVVNPVYSGDGNNETEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA35</accession>
    <name>A0A8B7YA35_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tumor protein p63-regulated gene 1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPRG1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090109.1">
        <property type="nucleotide sequence ID" value="XM_022234417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YA35"/>
    <dbReference type="GeneID" id="110978990"/>
    <dbReference type="KEGG" id="aplc:110978990"/>
    <dbReference type="OMA" id="WNPWSSN"/>
    <dbReference type="OrthoDB" id="10012704at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034753">
        <property type="entry name" value="hSac2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022158">
        <property type="entry name" value="Inositol_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040242">
        <property type="entry name" value="TPRG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108:SF1">
        <property type="entry name" value="HSAC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31108">
        <property type="entry name" value="TUMOR PROTEIN P63-REGULATED GENE 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12456">
        <property type="entry name" value="hSac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51791">
        <property type="entry name" value="HSAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSac2" evidence="3">
        <location>
            <begin position="84"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090109.1"/>
        </source>
    </evidence>
    <sequence length="296" mass="33074" checksum="AF02718B8C5A0410" modified="2022-01-19" version="1">MTDKQEPNGNTNIEDNLDDGSVPDVSFQGGTLSLSNVETNLLHDERKPTAPTSLPLNNVNNANFVRGRPKSAPLSPVVQDGFYASKMGRLESAVLECKKATIKDDMDGEVHGVWLLTEIDHWDNEKERLIIVTSNSLLLVKYDFVAGAVRQFQRINHIAVDALQIGVFSYPQKSLVSPRDGTGLRIIWSHGRQPTFMERWNPFCSTIPWLTLTSHPLEHSGTREAETYQIDPFKNAYIQAINNWRIKQNQALNNVSSSPVTIVDAPIECDVMLGLASTVHNQSRLGFYRERGGVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAJ3</accession>
    <name>A0A8B7YAJ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Kelch-like protein 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10" type="primary">LOC110979060</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090242.1">
        <property type="nucleotide sequence ID" value="XM_022234550.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090243.1">
        <property type="nucleotide sequence ID" value="XM_022234551.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090244.1">
        <property type="nucleotide sequence ID" value="XM_022234552.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090246.1">
        <property type="nucleotide sequence ID" value="XM_022234554.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090247.1">
        <property type="nucleotide sequence ID" value="XM_022234555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAJ3"/>
    <dbReference type="GeneID" id="110979060"/>
    <dbReference type="KEGG" id="aplc:110979060"/>
    <dbReference type="CTD" id="339451"/>
    <dbReference type="OMA" id="RRNCWEP"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF475">
        <property type="entry name" value="KELCH-LIKE PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00501">
        <property type="entry name" value="KELCHREPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="67"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022090242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022090243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022090244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022090246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090247.1"/>
        </source>
    </evidence>
    <sequence length="610" mass="67642" checksum="8211EFFABCB9C19A" modified="2022-01-19" version="1">MEVKSELSVQVSHHRSLSRHPASPVISPVGCISQNAKLGEFFTHRASRHANDAFVAMNRMRQQATLCDIVLKVGDKTIMAHKLVLASCSAYFHAMFTSDMSESRQSEVHLRDIEAQAVEQLVQFAYTAEINIGEKNVQSLLPAASLLQLHSVRDACCKFLLGQLDPSNCLGIRRFADMHGCYDLEQSSHLYSLQNFNHVVNTEEYLHLPADEVMQLISSEQLNITSEEDVFNAVVLWVRADMPTRQRYVAKLMERVRLPLLTRDFLVNTVETEPIIRSSPECKDLLIEALKYHLLPEQRAVMQSPRTQERHNSACVPMLFCVGGGSLFAIHSECECYDPRSDTWHPLAPMSSRRARLGVATVGRLVYAVGGYDGSNDLALVESYNPQTNTWKEITPMGTKRSCLAVASLNGLLYAIGGYDGASCLNSVERYDPLTNTWTSVAAMATRRRYVKVAVMDGCLYALGGYDGSCHLSSVERYDPQTNSWAQMPHMISRRSSTAAAVVEGVLYVVGGNDGAACLSSAERFNPDINLWEPVPSMSIRRSTHDAVAMDGQLYVVGGNDGSSSLNSVERYDPKSHHWNTINTMVTRRSSVGVTVTKVVSHLGLNQVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAM6</accession>
    <name>A0A8B7YAM6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 17-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090278.1">
        <property type="nucleotide sequence ID" value="XM_022234586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAM6"/>
    <dbReference type="GeneID" id="110979078"/>
    <dbReference type="KEGG" id="aplc:110979078"/>
    <dbReference type="OMA" id="CQECKGF"/>
    <dbReference type="OrthoDB" id="79426at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052630">
        <property type="entry name" value="TTC17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16091:SF3">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16091">
        <property type="entry name" value="TTC17 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090278.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="40753" checksum="09BF639219DDA5BB" modified="2022-01-19" version="1">MTFDTPNLTYMALYLVGASMVASTPRSATHWKLQKGEDGVVLVQPSLAEDAAKVASEDPVLTILTQQNNYDVVDQEGNRGDRIPHEGECVSCEKLEGNERPKFQPVKHKNLDALECTKHVNKTAYDSLSGIIDRAKHPSIPEPEVALIFKRSDSDQVDMSALEKSLRERIIETPNSLAVLNQVGNYWRIKGNTFLAIECFRKALSISPTNPDILLNLARVLFNAQRLPDALLLTQKSLQHKAPDQNAWLQHFTLGEVHKALGHYPEAGTHFRHSLDLNPTFQPAEAHLRDMEQPLGATNATLYTILIIGVLISAVCVVLYYVTEAYLKESNQHPRRSPKLAVPWDRVRFPIPPRLMKNKRGGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YB23</accession>
    <name>A0A8B7YB23_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Squalene monooxygenase</fullName>
            <ecNumber evidence="4 9">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110978788</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="4 9"/>
    <dbReference type="RefSeq" id="XP_022089762.1">
        <property type="nucleotide sequence ID" value="XM_022234070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YB23"/>
    <dbReference type="GeneID" id="110978788"/>
    <dbReference type="KEGG" id="aplc:110978788"/>
    <dbReference type="CTD" id="6713"/>
    <dbReference type="OMA" id="AKRTFYW"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000662">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="11">
        <location>
            <begin position="120"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022089762.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="46714" checksum="36FC7E23167A304F" modified="2022-01-19" version="1">PDRIVGELLQPGGYQCLKALGLGDCAENIDARSVEGYVIHDLDSKSKVDISYPKDEGDHVKSGRAFHHGRFVMGLRRAAMKQESVTYIEGTVTKILEQDNCVIGVIYKKKGQEQEQEIYAPLTVVADGCFSKFRKSLITTNVKTTSHFVGTIMKNCPQIKDNHAELVLANPSPVLIYRIAEKDTRVLVDVRGTMPKDMKGYMSQKIHPQLPEHIKEPFLDSLQNDRIRSMPSSFLPPAPIEKPGVLLLGDAMNMRHPLTGGGMSVALNDVRIWRELLKGIPDLDDHDKIIQSMRTFHWLRKNSHSFVVNVLAQALYELFAATDRHLMQLRRACFHYFKLGGQAVSGPVGLLSVLQPRPFVLIGHFFAVALYAIYFAFKSQSWLTKPFALVESVWIFAKACMVLFPLIRSEMHSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YC38</accession>
    <name>A0A8B7YC38_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110978505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022089251.1">
        <property type="nucleotide sequence ID" value="XM_022233559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YC38"/>
    <dbReference type="GeneID" id="110978505"/>
    <dbReference type="KEGG" id="aplc:110978505"/>
    <dbReference type="OMA" id="EQTIHIC"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016206">
        <property type="term" value="F:catechol O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042424">
        <property type="term" value="P:catecholamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000054">
        <property type="entry name" value="Catechol O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022089251.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="37428" checksum="402805359771606F" modified="2022-01-19" version="1">MQFPHYLECKAIAAPVHSIEQTIHICVRSRGHIHGPTFYGSCSSITNRDSLHTADAQQLTTNAKNCLLQVSCVFEISVPGRNTTKFRKSKTMALNTWSYATRYIMKVIVPGYLRRVRHGNTTEERLLEYVKSTAVQGDAASVLSAVDKFKAEKEWMMHFQYEKRQKIDGVLKKTKPQNGLELGTYVGYSAIATSRHLSEGGHLISVEIDKKNASLAKQFIEFAGVSNQISIAVGKSSDIIPELRSKYSVDKLDYVFLDHWNSLFLPDLKLLKKHGLLRKGSVIVADNVLYPGSPDYLQYVENSGEFTTERFDCYVQFMRLQDAIAISVYNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCJ2</accession>
    <name>A0A8B7YCJ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110978594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089401.1">
        <property type="nucleotide sequence ID" value="XM_022233709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCJ2"/>
    <dbReference type="GeneID" id="110978594"/>
    <dbReference type="KEGG" id="aplc:110978594"/>
    <dbReference type="OMA" id="HLTRECH"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003828">
        <property type="term" value="F:alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23963">
        <property type="entry name" value="GT29_ST8SIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050943">
        <property type="entry name" value="Glycosyltr_29_Sialyltrsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987">
        <property type="entry name" value="ALPHA-2,8-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11987:SF52">
        <property type="entry name" value="CMP-N-ACETYLNEURAMINATE-POLY-ALPHA-2, 8-SIALYLTRANSFERASE-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022089401.1"/>
        </source>
    </evidence>
    <sequence length="357" mass="41852" checksum="F413619825535BE7" modified="2022-01-19" version="1">MNGEPRMRQLKRIRQLFVLCVIMIAVYVVTFGIDTAIDCYQFCQGKTCFSSRLTILVYRDNVSPKEMDFLQNFRLNVGYYKYATDHLSGRYDPESCSMEEYFSQFTTIPAYNNCAIVGNSGILLHSNCGNEINSYDYVIRVNLPAIQGYEEDVGFKTNLTLLNFETLVYLHSNLTQKELGDEFHDMYVKRVLFLNDSVLWYGKSMGPRETRKRLQQSVEILKGTYKLPVRIGFNWRPLHPEKFVGMKRLATSGFMAYYAAKSFCSHVTLYGFYPSSKDARGFHLPHHYYEDVPYEYSNPIHDLLWEFQKYREYASEGKLHLVTEKCADSTDRDETRWANQDREKPIGDLIWFKQRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCP5</accession>
    <name>A0A8B7YCP5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin conjugation factor E4 B</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase E4 B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin fusion degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110979100</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022090327.1">
        <property type="nucleotide sequence ID" value="XM_022234635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCP5"/>
    <dbReference type="GeneID" id="110979100"/>
    <dbReference type="KEGG" id="aplc:110979100"/>
    <dbReference type="CTD" id="10277"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16658">
        <property type="entry name" value="RING-Ubox_UBE4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000060">
        <property type="entry name" value="ubiquitin conjugation factor E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="18">
        <location>
            <begin position="1077"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022090327.1"/>
        </source>
    </evidence>
    <sequence length="1151" mass="129460" checksum="E68471A268CEF030" modified="2022-01-19" version="1">MSELTPDEIRRRRLARLDKSPLAGAAKATPATEETPNKLGASSVTSEDEGEGQGAPEATPASPSEAPSEGLQAASGALEASSQPGMETDESASSLSQPTETMESAPDVHDSLDSGFPASMEMDSETCDQGSLSQMDVDSGIENPELEETVKKGKKPSAEKKCPSEAELLQVVSRVFHVSWKEQGKDVVYLAGLATEFAEEPEQVFPNTEDLISQVLMEVLTQHACTGNPFANLSATTSPAVATAGAGGHSPQSSSQQTSVAPSSAGDQCSSKPENPEPEMLSYLLQCYQRIRNEERTAPKRYSQPPFSNLASAARLQCVHHAGLVLQGAFTQPGSSTLLLAPLLLSHSLPRGFLQELVSATRADNASFQMIFTPVIIALVQAIQRCSLDSDSYKAPLSAMNELCKIKLGNSRPICRLVSSLPQWLPDPITGALGREVEKVSLLGAFLSLSVFAEDNTKVVEKYFSGPMLTQDSIRILNDSLQHHLHFIRNELHEIIHSILVNSESREAMVKYFAAVIKRNHKRAQMQIDESLVAGDGFMLNLLVVLQRLSVKIKLDMVDVMYPHHPKSLIDISQDTRLKASSQEAADWVEECNKRPAAWLEPKFPTQCYFLTLHCQHLALMPACRHYTRRIRGLRELARMVEELQGQEEQWKGTPNERRNRQLLEKWKLQIKKLDKAKLCGDAGLLDENLLRNCFQFYGTVMFLLLKLLTPKDQDRICLPLPKEVPMEFAALPEHYIEDIAEFILFIVQHCPQALEDTAQQDMVLFIVVIVCSAHCIRNPYLVAKLVEVIFVLSPAVQTRTAKIYEAIQIHPLAINHLVPALMTFYTDVEQTGASSEFYDKFSIRYHISIIFKSLWRLPMHRNAMIKFSGSQSEFVRFINMLMNDTTFLLDESLACLKRIHEVQEAMKNKEAWSALDQEERQGKIRQLSTDEKQCRSYLTLANETLEMFNYLTKEIKQPFLRPELCDRLAAMLNFNLQQLCGPKCNDLKVENRDKYGFQPRRMLDQLATIYLHLDSEELATALANDERSFRPELVSDALHFLARLKTQSEINQFSRLMSRAQEITSHNQQLEVDYDDAPDEFKDPLMNTLMHDPVILPSGHVMERKIIERHLLNSQTDPFNRQELTSDMLQPATDLKKRITEWIQSKKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGB0</accession>
    <name>A0A8B7YGB0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 179B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110979703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TMEM179 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091435.1">
        <property type="nucleotide sequence ID" value="XM_022235743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGB0"/>
    <dbReference type="GeneID" id="110979703"/>
    <dbReference type="KEGG" id="aplc:110979703"/>
    <dbReference type="OMA" id="NGAHFYD"/>
    <dbReference type="OrthoDB" id="6423876at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029673">
        <property type="entry name" value="TMEM179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059010">
        <property type="entry name" value="TMEM179-179B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31872:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26158">
        <property type="entry name" value="Claudin_TMEM179-179B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022091435.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23120" checksum="E3E03405A15C9C03" modified="2022-01-19" version="1">MPAKTTIVNIVEVGVLLVALGCGMAASIMIGVTSTQMGGCVLKASVARLDSKRFTVTHSSQSRCQFCLVTQVVGILLALVFIAYRIQVICRGKLEIQACGRFVVTIVFGVMAFFVLVEACLVTVGLKTFCNNLLDLEGAARPNTCAGFQRGVDWKAIDGSAFYYNLTTAEAASWISLLCWLCLTGISLVTSFCLNRRIRALARAQHTAQAKPVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGD5</accession>
    <name>A0A8B7YGD5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADAM10 endopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.81</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endopeptidase of broad specificity.</text>
            <dbReference type="EC" id="3.4.24.81"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.81" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022090711.1">
        <property type="nucleotide sequence ID" value="XM_022235019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGD5"/>
    <dbReference type="GeneID" id="110979325"/>
    <dbReference type="KEGG" id="aplc:110979325"/>
    <dbReference type="OMA" id="VDPCCTP"/>
    <dbReference type="OrthoDB" id="2149267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049038">
        <property type="entry name" value="ADAM10_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21299">
        <property type="entry name" value="ADAM10_Cys-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034312321" description="ADAM10 endopeptidase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="8">
        <location>
            <begin position="304"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="7">
        <location>
            <begin position="541"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090711.1"/>
        </source>
    </evidence>
    <sequence length="850" mass="92401" checksum="85649E9961325B14" modified="2022-01-19" version="1">MALNRHLLLALLIMLLSPRQTVCKLENKDGMPLSRYIHHFEPLNYDVGPLDAQHNSQPRNHMGQLYNDSSITWKLTAFGRSFHLQLSPYSNVVSPGAQLNVVSALGVNTTDMVSQLYRGVVIGDERSSVYGHIINGTFDGIIKTDYETFHIEPSFRYFSSPRPGFRSVIYRARDIHLEDQPITNRSATCQLCSLSWDGAKLISPKMYTLRGNKDPDKRKDIFPHISLSEGVGKRKLPTAPSNSQSHENILLAKQSFSDSDWLQMSPDEALRQSEGRTPRDAVHLEGNHTSGWHEWLTTYDRPSKTCMLHVVVDHTFFEHVAGGDVSLAAAEVAFHITEADSVYRATDFDGDGRADNVGLAIGGMTIFESVDAQNYLVSGDYPDAEEFLTDVSLYNFSAYCMGLAFTYRDFAGGILGLAWMGYPGFSEPPGGICQSQITYRNDGHPSSLNTAMVTLVNYDTYVPRSVSVTSVMHELGHGFGSPHDPRTRSCSPAGPQGNYIMSSQATDGNQPNNIRFSTCSRGPMAAVIATKGALCLQADSGPHCGNGLVEQGEECDCGTALLCHLADRCCTPKGGAGSDAECTFRRQLGRVCSPVTSPCCDDDCRLIPASWHKHCFEDDECLAVSFCNGSSADCPPPVPSPNGTPCQDGAKRCLDGQCSLTACSAVGLPECFCSDVNSTGQSCQLCCQHEGDCIPAVEFGLTTLTGDVILKQPGSSCDNYTGYCDLQGLCVTTDSDSALNKLKNFFKEGRGPIHWTNTHWYYIACAVLSFCFSCLMAKLSYDNRRYLQNALLRMRHPRSTLEPAGAHQGTGGAEGGHGVSLVAPASHATTAGLQFLLESAKPASPTSTQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGM8</accession>
    <name>A0A8B7YGM8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110979895</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091742.1">
        <property type="nucleotide sequence ID" value="XM_022236050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGM8"/>
    <dbReference type="GeneID" id="110979895"/>
    <dbReference type="KEGG" id="aplc:110979895"/>
    <dbReference type="OMA" id="IHWLLFT"/>
    <dbReference type="OrthoDB" id="10461897at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091742.1"/>
        </source>
    </evidence>
    <sequence length="207" mass="23329" checksum="0260FA3214F9667C" modified="2022-01-19" version="1">MAHRKVHSREKMTRVFLLVIAIYLDCVWSMEGNVTTEEAETTPSLSGTASEADARTENPTSSRHASTNTEDTLPSTERTSPSGEHDVKSSPFGNTSISTSILTTEHPTDASPQYGEIHWLLFTGWQMPLFMVCVEIFAYCVTIFIVFGFSQKRSRVKRFGHFSWKGPNPFQVQDAKNVKAAREHYIGTDFKEGRFKAKKPSIRGHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH08</accession>
    <name>A0A8B7YH08_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">mRNA export factor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110980281</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092528.1">
        <property type="nucleotide sequence ID" value="XM_022236836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH08"/>
    <dbReference type="GeneID" id="110980281"/>
    <dbReference type="KEGG" id="aplc:110980281"/>
    <dbReference type="OMA" id="YSHNTRD"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000084">
        <property type="entry name" value="mRNA export factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="38"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="85"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="126"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022092528.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41299" checksum="5DA9AB910A24C457" modified="2022-01-19" version="1">MFGTSAGLGGATGGSGLFGQTTGAPGGSHNPMKDFEVTSPPDDSISSLAFSPDTLPTTFLIAGSWDNNVRCWEVQSTGATVPKAQQTHQGPVLDVCWNDDGTKVFSASCDKTAKMWDLNSNQAIQVAQHDAPIKTIHYIKSPNYSCIMTGSWDRTLKFWDTRSSTPMANIQLSERCYCADVVYPLAVVGLAGKKINLYRLESGPQEVKINQDSPLKFQHRCVAIFQDTKKTGPAGYALGSIEGRCAIQFEPAATPKDNFTFKCHRSNGTSSYSSYQDIYAVNSIAFHPEHGTLATAGSNGKFSFWDKDARTKLKTSEEMENPITACTFDAKGNIFAYAVSYDWSKGHEFYNPQKKNYIFLRGHAMEELRPRNRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH25</accession>
    <name>A0A8B7YH25_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Serine/arginine-rich splicing factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110980290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092544.1">
        <property type="nucleotide sequence ID" value="XM_022236852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH25"/>
    <dbReference type="GeneID" id="110980290"/>
    <dbReference type="KEGG" id="aplc:110980290"/>
    <dbReference type="OMA" id="PLIRCDV"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061574">
        <property type="term" value="C:ASAP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12311">
        <property type="entry name" value="RRM_SRSF2_SRSF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481:SF0">
        <property type="entry name" value="LD23870P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15481">
        <property type="entry name" value="RIBONUCLEIC ACID BINDING PROTEIN S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="14"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022092544.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="26594" checksum="69B73BE9F77F88D1" modified="2022-01-19" version="1">MSHGGGPPDIEGMTSLKVDNLTYRTKPEDLYKVFSKYGDVGDVYIPRDRYSKESRGFAFVRFFDKHDAEDAMDYMDGAAMDGRDLRVQMARYGRPSSDYNRRPRSRYDRGGGGRYGGYGRRGRDSRSRSRSRSRGRWRGRSRSRSPRRSPRRSPRRSPPYRRRRSPSRSRSHSHSPPPRRSRSPAKRSRRSNSRSRSRSGSKSPRQRMQSPSRSRSRSRSRSGSYSKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH35</accession>
    <name>A0A8B7YH35_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyltransferase-like protein 17, mitochondrial isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091897.1">
        <property type="nucleotide sequence ID" value="XM_022236205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH35"/>
    <dbReference type="GeneID" id="110979984"/>
    <dbReference type="KEGG" id="aplc:110979984"/>
    <dbReference type="CTD" id="64745"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091897.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="59247" checksum="43B6A234E90BAE6B" modified="2022-01-19" version="1">MAASMDSMFRLLAGKRKMHRIVLRSGVIMNVKRWLATVANYQTTVDNSLTELKTFRKHPGIMRTKNVKLPDALLQTLNRYLADKPMKQLAPRAKALSNYLWSRQLPLEEAQLRAKAQEYAQLQGVEDIDEDMLHSQDLPKDHKKKVASIMNKLRRHIYHWQPIRFDETTVCAYTMSRIAPNYATIYRVLHEIKKRVPDFSPEALLDFGSGIGTVSWAAHALWGNTIKEFYCVDTSREMHDVAEALMKERQTEDGESRNIIKGVYFRHFLPMSLQKKYDLTISAYSLLELPSRTDRLNTLRTLWRKTDQFLILIECGTNEGYKTIMEARDFILNDIQKEEERNLLKRRVAEGVTREVAREEVGLVEHSTTLAGHVFAPCQHDQDCPRITDSSKTPCNFEQDFHHFSKREEIIKERFSYLVLRKGPRISGDDTGHWPRIVRPVLPRSRHVICRLCCSNGQLEEAVITRAKHGRELYRCARYSAWGDLLPICRPQENVLPEQQTDTEGLHSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YI19</accession>
    <name>A0A8B7YI19_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ethylmalonyl-CoA decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Enoyl-CoA hydratase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Methylmalonyl-CoA decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16 17 18 19 20" type="primary">LOC110980172</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but also has some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2</text>
            <dbReference type="Rhea" id="RHEA:59540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:85316"/>
            <dbReference type="EC" id="4.1.1.94"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:59541"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(2S)-ethylmalonyl-CoA + H(+) = butanoyl-CoA + CO2</text>
            <dbReference type="Rhea" id="RHEA:32131"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:60909"/>
            <dbReference type="EC" id="4.1.1.94"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:32132"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2</text>
            <dbReference type="Rhea" id="RHEA:61340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57327"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="EC" id="4.1.1.94"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:61341"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.94" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022092257.1">
        <property type="nucleotide sequence ID" value="XM_022236565.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092266.1">
        <property type="nucleotide sequence ID" value="XM_022236574.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092276.1">
        <property type="nucleotide sequence ID" value="XM_022236584.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092285.1">
        <property type="nucleotide sequence ID" value="XM_022236593.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092294.1">
        <property type="nucleotide sequence ID" value="XM_022236602.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092301.1">
        <property type="nucleotide sequence ID" value="XM_022236609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YI19"/>
    <dbReference type="GeneID" id="110980172"/>
    <dbReference type="KEGG" id="aplc:110980172"/>
    <dbReference type="OMA" id="FTICRPE"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004492">
        <property type="term" value="F:methyl/ethyl malonyl-CoA decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000109">
        <property type="entry name" value="Enoyl-CoA hydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF27">
        <property type="entry name" value="ETHYLMALONYL-COA DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022092257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022092266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022092276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022092285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022092294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022092301.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="35928" checksum="1EEC78E70926DAA2" modified="2022-01-19" version="1">MRSRLLQLRSQVTPILSGLRHRPIHYQTDSSGIKLSETANSHYMDQRRNTALANEFVPSEVFNERVERLNLKELNGGSLRLSKNDVTGLATITISNVTNANAMSGSMMVDLSDIVADLEKWQRGKAVILHGDPEGKNFCSGADLKTTEALSSPQAGVVMCLFMQNILTRLQQLPLISVAAVSGSAVGGGAEIITACDFRLVSPSSVIQFIHCKMGLSPGWGGGTRLVRLVGPQKALKLLAGGESIRATESLGLGLADDLIQGDDIIKQASDWLDKYTSQPVEVVRAMKNVVTAASQLPPDKALSKEKDIFGGLWKGPANKEALARALSKKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIB2</accession>
    <name>A0A8B7YIB2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Protein Smaug homolog 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC110980526</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMAUG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092983.1">
        <property type="nucleotide sequence ID" value="XM_022237291.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092984.1">
        <property type="nucleotide sequence ID" value="XM_022237292.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092985.1">
        <property type="nucleotide sequence ID" value="XM_022237293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIB2"/>
    <dbReference type="GeneID" id="110980526"/>
    <dbReference type="KEGG" id="aplc:110980526"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030371">
        <property type="term" value="F:translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09557">
        <property type="entry name" value="SAM_Smaug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000013">
        <property type="entry name" value="Protein Smaug homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.170">
        <property type="entry name" value="Smaug, PHAT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037093">
        <property type="entry name" value="PHAT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058599">
        <property type="entry name" value="PHAT_Smg/ZCCHC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037634">
        <property type="entry name" value="Smaug_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26034">
        <property type="entry name" value="PHAT_SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="368"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="271"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="469"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="651"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022092983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022092984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022092985.1"/>
        </source>
    </evidence>
    <sequence length="725" mass="80308" checksum="1EBF3A6E134727C3" modified="2022-01-19" version="1">MKPAYLFRDQVNALAIWFKEWNDCEQTVALYSLLRRVSPTQARFLTQVLEQTLADSDECQRLEQEANDISFVCSLCNESKEIAVAQLLSHLPLLRPGNNDVKKEYLSLIPKILLHSVENSQHLEESRQVLSYLLIHPALSNEDRSSLAWWLGRLEEHTNSQAGFPSRLQVSPDLSPSQSPSPSPSPFPGGILNSSETGRNGLQGGLNGWRAQPTFRDSGAVDFPPTASHFLGSSVPHQPLTNTLSAPPAVNVTGPSNDVASKYFSSSLAGPSLPVHQRKSRSHSLTPPNSCSNTPSPQPLTDWPSEEELEPRTSRSLSLPIDHAPLSPQSSTASSGSSTEAHGEDGGLWSHGGGSGQPGPPKRNSFLEENSGMRDVPSWLKSLRLHKYSGLFQQMTYDEMMLLNEGKLESMNVTKGARHKIVLSIQKLKERQLTLYNLEKDILNDNSPGNLRNALNEVKSMLNTPIKVYEPLESSSEDSTSSQPSEDGEKETKEGDFPGQLTRFMGKMCTQLLVAKRPDEDNVSLYLQLLDKCLNHEAFTAAQKKRFLSWRQSCQKFSRNPYPRKLSLQETKQPRTWGHYSSNYPGDYGVFAAQGPGGNRRPTRPPFAQPQPQGQAQPHPQRINSLLTGGGSPALFRPTQTSNMYMKPRQLPGNPHIGVQRTKSAPIRRSSQPAQPYLYQAPPPQDVSNQPMGDPEITNRLENLCLSMTEHALSDGGEQHKSNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIW3</accession>
    <name>A0A8B7YIW3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription elongation factor SPT6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110980633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SPT6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093194.1">
        <property type="nucleotide sequence ID" value="XM_022237502.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980633"/>
    <dbReference type="KEGG" id="aplc:110980633"/>
    <dbReference type="CTD" id="6830"/>
    <dbReference type="OMA" id="GYFYLCF"/>
    <dbReference type="OrthoDB" id="343921at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060429">
        <property type="term" value="P:epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00164">
        <property type="entry name" value="S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000494">
        <property type="entry name" value="Suppressor of Ty 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000002">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000004">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3500.10:FF:000006">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000030">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000089">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="10">
        <location>
            <begin position="1283"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="9">
        <location>
            <begin position="1379"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1695"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="512"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1695"/>
            <end position="1755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1756"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1777"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1804"/>
            <end position="1817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022093194.1"/>
        </source>
    </evidence>
    <sequence length="1866" mass="214296" checksum="087783D82598C09E" modified="2022-01-19" version="1">MADFFDSEAEVSEEEDTKLSSDEEDEEEGDEGENENLDDLINDEDEEEDQGGSDSDGDIGKRKKRKRREIDDRLEDDDYELIEENTGVKVERKKFRRVRQISDEEDSEDEEGNSGPQTETTQRDAIAKEIFQDDIEEGEDEEPPEEGEIREISAEDNQYAEIESDEEESDPDDFIVDDEGQPIARRKKKGHKSHRYTDSALQEAQDIFGLDFDFEEFDQYREDYEEALEEDSEYEDEEEELGEEVPRRVRKAGKKRASKKSIYDVFEPSDLERGHFTDIDNEIRAADIPERLQLRRVPITKADDAELDEEADWIYRQAFLTPPVSNQEFSEDSGYGSGYERKPPRTKNRIREALHFMRNQHFEVPFIAFYRKEYVEPELNFNDLYRVYHWDEKWCQLKNRKSNLKKLFEKMQAYQFDQMSKEELLPDSVRPLTETDLDRLNDVDSMDKLKDVYMHFLLYYGRDIPKMHNALNRPKKNVRTKLVRRPAKKTVKVMVRRPKQKKKLNEDDSDSENDKDWTEEDAKREEDSDSEEEVETEEEVETEEEVEVEVDEDGNEETEDGTSHQIKQATRKSMYAICQEAGLDALAKKFGLTPEQFGENLRDNYQRYDPEQHPVEPSETSREFTGSKFQSEEAVMKAARYMVALQLAHDPLVRQCVRQTYYERAKISVRPTKKGVKEIDEFHPCYGCKYLKNKPVKDLFGDKYLKLLQAEEEKLIKMTMDIDLDKSSSDSSYQSQSYFDEIKQLYYRDEFSHTVQEWNKERSSAIETALYKILYPEMAKELKSRLVQEAKDGIIKMCCRKMFDWLKVMPFQADQQLEEDEDDYLDGQGHVGLRVMGLAFTSEMDNAAFCVMIDGDGEVSDFLRLPHFLRRADSYFQRDRDLKLADLEALKEFLSSKKPHVVAVASESRVTLGVIKDVQQCVSDLEAEQQIAPISVQLLDSNVAQVYAATNMAETEFRKYPQLLRQAISVARRLQDPMVELARLCNSDEDLMCLKFHPMQDSVNREELQEALHQEFIYRVNEVGVDINRAIAHPHTQSLVQFICGLGPRKGNAIIRTLKQQNQRLENRNQLVTVCKLGPKVFINCAGFIKIDTASLGDSSDSYIEVLDSTRIHNETYEWARKMAVDALEYDESAEDANPAEALEEILDNPDKLKDLDLDAFAEELERQGYGNKSITLYDIRAELNNRYKDLRSPYHPPSAEETFSMLTKETPETFYRGKMVLCTVTGIARRRPQKDQLDQANPVRNDETGLWQCPFCQQDNFPELSEVWSHFDGGDCPGRSVGARTRLDNGIAGFIPTKMISDKQVNSPEERVKVGMTLHCRITKIEIEHFRVDLTCRSSDLQDKNGEFAPPRDTFFDHTLFEKDQRKDEESKKKTAQAYVKRVIVHPSFHNITFKDAEKLLVNMDLGEVVIRPSSKGSDHLTVTWKVDEGIYAHIDVREEGKENAFSLGTSLWIGNEEFEDLDEIIARHIQPMASYVRDVMQHKYYRDTEGGKRDAMEKLLAAEKRKTPSRIPYFMSFSKEYPGKFLLSYQPRSKVRHEYVTITPEGYRYRGQAHPSLNALHRWFKEHFRDPIPGLTPASIHRTPMVAAPERTPAVYSYMGTPMIQKSGAGYSQLYATPSMSIATPRQTPGATPQINAARYGTYSGAYSNIPAYATPQNNPLATPMMTPSYQAMQTPSQGPMRTPQINAIRTPQINPLRTPQTNNPMRTPQQNPLRTPQQTQAAAGSTTPQINNPLRTPQYQPTPKQSWSSSATAQQVVNALQQQLQRAGGSRSNAASVDWASQAAQWASRRQGHPKDKNPQASPANPSSRASAASYQPSPRGYPQPSPKTYTGRSPYPEPSPMSISTTPAPSMGGDATPLIDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJI4</accession>
    <name>A0A8B7YJI4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/potassium-transporting ATPase subunit beta-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110980765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093414.1">
        <property type="nucleotide sequence ID" value="XM_022237722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJI4"/>
    <dbReference type="GeneID" id="110980765"/>
    <dbReference type="KEGG" id="aplc:110980765"/>
    <dbReference type="OMA" id="WEGFRVF"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF28">
        <property type="entry name" value="NA_K-ATPASE BETA SUBUNIT ISOFORM 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022093414.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34998" checksum="1C68D4A286FBC2E8" modified="2022-01-19" version="1">MGGEDKPTFRQKVRTNWAAFRIFLWNSEKREFLGRNAKSWGQIGIFYLILYICLAGFWALMLFIFMQTVSPDHPTYNSYVNVPGVTLRPKFYKGDVVFNPEVPESYKDEIEDLKKIWNSLAPENQTDEVYVDCLNDTAPDGKFCRFDREVLGPCRPPMFGWDEGSPCLFISLNRVSEWIPEDYDEDSVPDVIKDVYEPGNIAFHCMDYKNKYDYSNNTIYPSAGIPFNYYPFVGTTDEDKRAHYIQPYVAVQFDLNVMDKKIKVQCRAYAGNLSPLGGLFDIDYVPDVVYEFVLSTKSKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJZ1</accession>
    <name>A0A8B7YJZ1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase III subunit RPC8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">DNA-directed RNA polymerase III subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">DNA-directed RNA polymerase III subunit rpc8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 19 20" type="primary">LOC110980858</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the RNA polymerase III complex consisting of 17 subunits: a ten-subunit horseshoe-shaped catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination. Interacts with CRCP/RPC9. POLR3H/RPC8 and CRCP/RPC9 probably form a Pol III subcomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093571.1">
        <property type="nucleotide sequence ID" value="XM_022237879.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093573.1">
        <property type="nucleotide sequence ID" value="XM_022237881.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093574.1">
        <property type="nucleotide sequence ID" value="XM_022237882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJZ1"/>
    <dbReference type="GeneID" id="110980858"/>
    <dbReference type="KEGG" id="aplc:110980858"/>
    <dbReference type="CTD" id="171568"/>
    <dbReference type="OMA" id="LGPTLWW"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000130">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="15">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="16">
        <location>
            <begin position="83"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022093571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022093573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022093574.1"/>
        </source>
    </evidence>
    <sequence length="206" mass="23257" checksum="0348397BDFAE923A" modified="2022-01-19" version="1">MFVLAEMTDTVRIEPWLFNVKLNSAISEELNKKLANKVVHSVGLCIALHDIVKLEDSHIFPGDGASHTKVHFRYVVFRPFMDEVLVGRIRSCSREGVHVTLGFFDDILIPPEALQQPSKFDETEQVWVWQYETEEGTHDLFMDTSEEIRFRVVDETFVDTTPVGPSDISEPGSEIVVDDSKSKQSPYSLTGSISEPGLGLLTWWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK80</accession>
    <name>A0A8B7YK80_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110980453</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110980453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022092835.1">
        <property type="nucleotide sequence ID" value="XM_022237143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK80"/>
    <dbReference type="GeneID" id="110980453"/>
    <dbReference type="KEGG" id="aplc:110980453"/>
    <dbReference type="OMA" id="RHLCEAP"/>
    <dbReference type="OrthoDB" id="5990066at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034084314" evidence="6">
        <location>
            <begin position="25"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="658"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="785"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="833"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="861"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="623"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022092835.1"/>
        </source>
    </evidence>
    <sequence length="955" mass="105966" checksum="0FF94A42F564EA33" modified="2022-01-19" version="1">MYLCTLGMLIMLLGAAVMIGVATAQEGVEDRLGDFANVSATLTVSCEEYEKRIGCNVERLCSCDELCETLNDCCQASYRDHVTKHGVVGSTSATGESNQSLIARDTPRTGAYHVCVELPSTLTGFKKNGLLFHNEYMLPQGYWMVGRCPPSWKDLDIRHLCEAPDDESDLMLLLPVVASNDPSTSFRNIYCAVCHGVPVSQMRTWRIQSNVSLASLKGANDSEEILQAVDSLKVFNTRNIQFKHDFEKLRSCVAHEIDNCPLDFGDDGIKRACRSHTMAVVHPVTHVRYRNWYCALCNNALHVTMCHLFKLGPHKVWSPTLTALVDFQGNRVSIRDIAGADSRPTHVENTCGRNEFLDPFTLRCRALMSSGGWEREIPSEPTIIQSECVQPGHVDVEIDMYFGQNSTSTPCELWGECLGVHDSSVWSTEWCKSQELHEERSGLFPVRVHLTVNSTIQALDKILNENPQVTQKRQCPSTASVMKVVLRKGCISPTGSRCMDYDTTNESSVYLAAWNNSESLYLRDFNGLLSLQDSLYQVTYTWSNGNTPDRAHSVSACGDFVHFNCSLIQINSSTFSQLLTDNQKPLADDGNHISLESGGDLVCYYLLSPPYFPQPGVFGGHAIFIVTVIGFLISMVALVASFVTYLVFPSLRNLPGRCVMSLIAAVFSAQLLLLITGDDVARSVSKASCTLLAVLLHYTCLSTFSWTNALAFYLARTLGPGAKPAAASQLRNSFMYFSFFGWGAPFIIVLTCIILHFVSLYGTYGVSEEYGGIRSCSFTDRIMEIAAFVAPVGISLLTNFGFFLAILVGFTFRRAPSTNLCSKEARTSRMRRDAFISIKIGFLLAFTWIFGFLASAFKSDVIVYIFCIMTSLQGVYIFLAFTFTKQVKALWREKLGLVTARSTTQKKTQRKYFKKPKTVVSSTAEKKAVCRKHSPSEQQTADTAHTCTAKNTDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN12</accession>
    <name>A0A8B7YN12_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110980471</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092861.1">
        <property type="nucleotide sequence ID" value="XM_022237169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN12"/>
    <dbReference type="GeneID" id="110980471"/>
    <dbReference type="KEGG" id="aplc:110980471"/>
    <dbReference type="OMA" id="YVYEERA"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034732469" evidence="7">
        <location>
            <begin position="16"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="134"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022092861.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="40451" checksum="5CB4E29306EBC628" modified="2022-01-19" version="1">MKFLLLLLCVALAQADLALIYRSNQRSVPDSWIIKIKDSDQLDQVAEDIISRFSRMRLPTPAMTKIRNLVPVLTMKIPAFLLEEIRSIDGIEYIEQNKIATLAATQSNPPWGLDRIDSRSGRDYYYTYNPSVQGKGVNVYIVDTGVQTDHTAFGGRASVIYGKEDDHGHGTHCAGTAAGNYFGLAREANIFSVKVCSPLCPLGTIIDGFNAVLSHDGGKGGVVSVSIGGFSNAPSITTAVNNLWNNGYLVSYAAGNDNDDTCNVHPQNGNNLIVTAASDDIDERAYFSNWGSCVDIFAPGVGILSAGYSKTINYDVAIKTGTSMACPHVTGAAALYFGKQGSSATPSSVKNAILNDATKDVITDTKGTPNRLLYVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNH3</accession>
    <name>A0A8B7YNH3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110981179</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094217.1">
        <property type="nucleotide sequence ID" value="XM_022238525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNH3"/>
    <dbReference type="GeneID" id="110981179"/>
    <dbReference type="KEGG" id="aplc:110981179"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022094217.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31187" checksum="1E94B96092E14C76" modified="2022-01-19" version="1">MHKFPHAKVAFLSSLKVKHSKHGARSVIDKLIMGNIDRLTFHPESDDVLDIGCGTGYGSVLIGSRVRSVVGIETDASKLEVAKRDYPADNVTYVKVDSIEDLGENFNKWRNGFDKVVCLCALYFVPDVEAVLRNAFDCLKPGGESLVIMPHDDHNLFQGALDFMLKHEEWKAFLKGFNNPLCLWKRNEQETQEFFTAGGWSDVSCEVQRVNLIHNAERAKLILWDMMGHVDQVDAAKREKCLEDLWQWARGEYQHTEDGSIIKPADWMVIHARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUF3</accession>
    <name>A0A8B7YUF3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">2'-5'-oligoadenylate synthase 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110982654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-5A synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096923.1">
        <property type="nucleotide sequence ID" value="XM_022241231.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096924.1">
        <property type="nucleotide sequence ID" value="XM_022241232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUF3"/>
    <dbReference type="GeneID" id="110982654"/>
    <dbReference type="KEGG" id="aplc:110982654"/>
    <dbReference type="OMA" id="RWYKQKL"/>
    <dbReference type="OrthoDB" id="1885901at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001730">
        <property type="term" value="F:2'-5'-oligoadenylate synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.20">
        <property type="entry name" value="2'-5'-oligoadenylate synthetase 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018952">
        <property type="entry name" value="2-5-oligoAdlate_synth_1_dom2/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258:SF7">
        <property type="entry name" value="2'-5'-OLIGOADENYLATE SYNTHASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258">
        <property type="entry name" value="2-5 OLIGOADENYLATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10421">
        <property type="entry name" value="OAS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polymerase nucleotidyl transferase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="2'-5'-oligoadenylate synthetase 1" evidence="3">
        <location>
            <begin position="171"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022096923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022096924.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39887" checksum="6696BA4B5440FB18" modified="2022-01-19" version="1">MGSWFSVGSDPWDLDPSYFEKWYNLNIREGLGKFETDALEAIDTALIALARRMACSKRNLFDVREVIKGGSLITGTATKDLTDIDVVVFVNSPHLVPIGCSSVQDYKAKLKSLIDELAKALGAVPSVIIRQSDACQVNFDFVVGGRSLRVNFFPTADNFSGYALGPSDIFKEMMQLGGYDRGLYSASLVKYQRDFVKNQPCTVKELIRLVKFWAHTCLPQALQKSYPLELITIYRWENTGKPALFKNVQGLKDVLRFLSALQVLRHYWTEMYDEELAEQSITKLGHRNPILLDPANPTNNVCWVYQKGDNIELLKSAAESTLRSKLLTDVIVYPNWWGRRDPYDFLCNDAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW25</accession>
    <name>A0A8B7YW25_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097514.1">
        <property type="nucleotide sequence ID" value="XM_022241822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW25"/>
    <dbReference type="GeneID" id="110982990"/>
    <dbReference type="KEGG" id="aplc:110982990"/>
    <dbReference type="OMA" id="WTTAGHA"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF10">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022097514.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="14853" checksum="D5D8F40157381C1B" modified="2022-01-19" version="1">MSWDSYLDNLIAQSKDSGGNAHVDKCAIIGIDGGAKWTTDGHANALKLTPDEAANIARAFKAKDFTTFMAGGVRAEGVKFQFLREEDKKCVYAKKKGDGALSIQSSKTALVLAHCPEGGQQGNTNKAVGVIAEYLESLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW58</accession>
    <name>A0A8B7YW58_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110982549</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022096720.1">
        <property type="nucleotide sequence ID" value="XM_022241028.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982549"/>
    <dbReference type="KEGG" id="aplc:110982549"/>
    <dbReference type="OrthoDB" id="5979328at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF600">
        <property type="entry name" value="PDGF- AND VEGF-RECEPTOR RELATED, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1310"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="130"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="244"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="650"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="768"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="999"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="1108"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="1214"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="1395"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1748"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1756"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1769"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1842"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1854"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1878"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1904"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2001"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="1429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022096720.1"/>
        </source>
    </evidence>
    <sequence length="2022" mass="224285" checksum="37318E2F510BDD7E" modified="2022-01-19" version="1">MAMHERYGTDQLLWVSERAMSCGPGTGSSGTECVGPGRGACGATVGRACRCGHGGHSLTGGTPSSSASGLRTAEENHFCYLRTRGSNYPFTDMRTRSPEFRTALSGIDSRWFKVKRLAWIVILVFALTSPLAADGLSVNVPESVNATAGKSTTIPCSYKDDKEGDMFEMSHGVYWTRTFANGSTEVLLNMTRSYLIFGKWYDRATIVNQASLEIYVVTSQDAGKYTCVVEGKRGTAELIVDRTPHIQTESQELTLNEGQTLELTCIGVGTLGWRWPRHDEQYAKVSHYDNLSPSLRRSVLQIQRASPLDTGEYLCTSSSDGDDEEKWTSVPVYIYIVQPDGPLFLDVDQTNLVHFWDETSLIPCRLATPDATITLHPQEKFITGDGTTPAQAAAYDPRRGFVIQPELPDYGGNVSCRAILGNRTEWQNFRVNDVVQPKLSVESSEKVISQDSDLELTCSGLQPIRWFTPSGLGDRLQINHTQAYLPSQPALYKSTLRLSGALSRDTGEFACKYQRYAELDRPELKSSVYVFVNSTDLEDFFLPSDVDVIYLENHTSPFTVPCRVSNPRPGDPVRLYAFYTETFTPVRDFVSQRTVTFDPKVGFWVDTKKKLTPKVKIWCVLGEISQNHYVSFKVLVEGETQDNFQTEIRPSASRLVQGEGPFSLTCLVNIPILASPFTLDIQPQAEFTFPGQEQDWQKDNARVESKHPKVDFEASTVISEHILTLQNVSLENSGIFKCRLFNVEQSKTLNASLRVLEEGIVDLTPYPPGQSMVEEVEGQDEVCLRAQIKSYPVAQYWWSKNGVNQSQEAAPRFTVLEDPQPADDSLIISGCISNVTAEDGGLYEVVAVNQYHTRKLTLQLSVLEIPEVNLTVTPAPTYQDPPLYFTEQNYSLVCQGRGHPAPLLSWEWRSCTSELCNHLGELTDDNQWIPVGAGAQSWAQAGDLSALASERSTTSVLSLGRVPQSGIFRCVGRSPSDQIQDVVYDTLEYRLTDLKFSLPAVQEVKTVYNFDQASLACKTNIYAFAEDAAWDWIPADNATSSEPIPISSDDERVTALGQTGFHYTSELTISRALANNTGVYRCWAQKRRTNESVVVYEVQLNVKEIVLPRFITELQRTYTLDRKKTIPFDFVLECRARGDPLPELAWSKDGRPITADNSTVTNIETGLVTNNTVASKLYLSPEVTPAHGGMYVCRVENKGGSALSAGELLIQESPTATISEEVYTHNIGDNLTIPCIITGEPAPEISWKWQPHEGNQLEDVPAKRYDNDARALVFKRLAEADNGEYTCVARNDHGEARDTVTLVIHRDNALLVPLLAGGIIAGIIFLILVLGIIAMAKRNFRLARKAKRNSANMELGLVNPRSPRGPASPFRMSFKEEFGDQLPFDPRWEFPRDRLKLGSVIGQGAFGMVLKGVAAGINKNERYVPVAVKTVKSDCSYVDRKALFGELKMLIQVGHHLNVVNFLGACTQDSPPLVIVEYCPYGNLSDYLRSKRDTFQAVKPAKSEAEENQENELNYADLLLREACVSEPPAAEYELVDKEAKRMAEKPLSVEDLVCYCFQVARGMEFLASRKCIHRDLAARNVLLGGNNVVKICDFGLSRSFYHDTDYIGSGKGLLPIKWMAPEAIFDKIFTTYSDIWSFGVFTWEVFSLGGSPYPGVQVDEKFYDKMKAGYRMSCPEHAPREVYNLMLECWSDEPKDRPMFSELAGQFGELLESNTRQEYIDLNIPYQEGQYCELDFGKLSINRKPDTIKEETETPQKPSDGKTTQDAADDHFGDPTYHRVPRDGEKDHTEGAAPQTEEGGNEPPSTEILGEASLMHRYSAGPGSQGPSKPQVQLPDSLPEDPYKGGTDEPLHTYTSVKGTRPGLSSDNVAGSGFARDAGKGRVDDLPSPDDNKLHTYASIKGSRPDKSAPSDPDKGLEGNHLYSSIKGGRPNVTLDATPKVKDQDGCTDPPEEETSLLGRPKLPARDCQSMSLGRLSDGKLGLQKPPLPKRDFSTLSWSPEKETLLSGPKSKDTDPRSVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW83</accession>
    <name>A0A8B7YW83_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Alpha-1D adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110982562</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096745.1">
        <property type="nucleotide sequence ID" value="XM_022241053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW83"/>
    <dbReference type="GeneID" id="110982562"/>
    <dbReference type="KEGG" id="aplc:110982562"/>
    <dbReference type="OMA" id="ICCALIP"/>
    <dbReference type="OrthoDB" id="2105199at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="25"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022096745.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37857" checksum="C6F508C999C0B980" modified="2022-01-19" version="1">MCQFFCERQALAALLISGAILGSVGNCFVVTAVALSRKLRTTTNVFVVNLAAADILTSLFVPWQAVAMLGGDDEWPIPGAKWLCVAAGFVIVVTFGCSINNLALIAINRWVGITKSRYTTRRIYTSCKLALMVIFAWAMPICCALIPVLTDFGELGYEKLYASCTWVIAKSVYYSIFLSAMYYPLQLILITLCYSSIFCYVRKTSQKMARADAPSISDKVSGGVSSRAIRKKLWKRQLDVTKNLLYIVLAFVLCLTPYFTTIIFTTDWSQRLVPWVGGILFFNSCVNPFIYATSHPDFKEAFGYMIRCRKIPTGSISQRKRSTATTSSQEHHTGTEQIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWH7</accession>
    <name>A0A8B7YWH7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982716</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022097042.1">
        <property type="nucleotide sequence ID" value="XM_022241350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWH7"/>
    <dbReference type="GeneID" id="110982716"/>
    <dbReference type="KEGG" id="aplc:110982716"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000029">
        <property type="entry name" value="Protein phosphatase, Mg2+/Mn2+-dependent, 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="212"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022097042.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="60313" checksum="AE47E5350A64B2EB" modified="2022-01-19" version="1">MGAYLSEPKTECVSDDGGTEKLRFGSSAMQGWRLGMEDGHNCIPHLDDETAMFAVYDGHGGAEVAIYCSKYLPDCIVDQEAYKNGDLAKALEDAFMKIDVVLKEPAVVEELRHLAGMEHNNDEADSEEANALQEEANLPLGELLARYSYHPSKTRTLRKKLDKNDLLSPMVRKKPPTFGEGEADVAVANGQENDGRVESDKGSIPLRLEVEEGTAESGSEVEGDGNGANAEGGVGDDQVREGEGEESGQDSLDTKCNGADAAESEKVNGRFEGGVENEGEDEESKDEEGQDEEQDEDEDDDSNSEEDYEGVEDQDEEEDEDEEEEEEDEQQDVFGQKEEPGSDSGCTAVVALMRDNQIVVANAGDSRCVLSKAGEAVDLSIDHKPEDKIEITRIEKAGGKVTPDGRVNGGLNLSRALGDHCYKCNTNLPPEEQMISAFPDIQTAELTKENDFMVIACDGIWNVMTSQEVINFVRERIAKQSSEGKPKLSDICQELFHFCLAPDTSGDGTGCDNMTCIIVQFDHDAPDQPVSVGSKRKASEGATTEENDSKRHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY30</accession>
    <name>A0A8B7YY30_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110982917</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022097395.1">
        <property type="nucleotide sequence ID" value="XM_022241703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY30"/>
    <dbReference type="GeneID" id="110982917"/>
    <dbReference type="KEGG" id="aplc:110982917"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030832">
        <property type="term" value="P:regulation of actin filament length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052409">
        <property type="entry name" value="Myosin-III_kinase_activity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256">
        <property type="entry name" value="AGAP011099-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46256:SF5">
        <property type="entry name" value="MYOSIN-IIIB-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="11 18" id="KW-0518">Myosin</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Myosin motor" evidence="21">
        <location>
            <begin position="9"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="20">
        <location>
            <begin position="861"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="18">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="785"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="975"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1035"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022097395.1"/>
        </source>
    </evidence>
    <sequence length="1091" mass="123931" checksum="DAE30DBCD9E2C72A" modified="2022-01-19" version="1">MASTDAPIGQTDDLATLGNLDEKILLGELKHRYNHDKIYTYVGDILVAVNPFRDLGIYGQKHAEMYKNKVRVDNPPHIFAVSDSAYQSMLTGSAVSGKKNQCIVISGESGAGKTESTKFIIKQIIELCKGKSQLEQQILQVNPLLEAFGNAQTTMNDNSSRFGKYIQLKFKEGKVMGAKISEYLLEKSRVVFQNKGEENFHIFYYMLAGLSPEQQKKYKMQVANKYSYLTNGPSSASTKQARMKEMLAELNNAMDLVGFLDEEQDEMYSILAATLMMGQIELDANEDDAAFVKGSDQAVATVAELIGINDEELRQVLTFNLSSARGDVFQRNYTKHQAQDARDAMTKTLYGRLFSWIVNKVNQLLAPEISLHVSETTEIGILDIFGFEQFQSNSFEQLCINLANEQLQYFFNQHIFLLEQEEYKSEGIDWTYVPFVNNQSLLDLFLAKPIGILALLDEECLFPKATDHTFVEKLNQNFARNHHFIKAKVASSNNFSIDHYAGRVEYTADLFLEKNRDTLPSKVMQMLRTSTNDLVSQIFRGTVTRTGTLALQSRRRRTRRSAKPKLGTRETVKKMTVGAQFKNSLSVLLELLNLSNPHFVRCIKPNTSKSAKLFEDKFVTAQLRYTGMLETTRIRRLGYALRPHFADFVKRYKVLARSPRLSEDKHGCVKILKTVGLTDWHVGKTKLFLKYYHQDQLEEHMQKLGKSAVHIQKVARGFLARCRYKSRVKKAQQQKEEMNSFLLQLAKLSLDQQHKLSKVLQGDKKIPKSFFESIRKGDKVIKIEAPSIQVQQGTNKKEDKVSSEEEEDGDDDEDEEIIEDEFVRIRNNLFGKEGTRQASIHWFKATQSMAVRDQTGTFAKWFHGIITRRRAEELLEHQPVGAFLIRVSESRFGYSLSLKAESRCKHFMIDLTPTGKYLVVGEMPVFKNLQELVKFYKVKPISPFGDVLKQACGQAENELDYSELLADKKNKRASGVPSSLVRKMKEKGMDQEEEAVYSPDGYSLAPSTGSSRRLERPVSEASYLYLDATNGKELSRTNSLDEVPPPLPERLYSGAYRLSRPPPPAPPEEDTSDSFPAVRAPPAKPYTPKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYC2</accession>
    <name>A0A8B7YYC2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21 22" type="primary">LOC110982964</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022097484.1">
        <property type="nucleotide sequence ID" value="XM_022241792.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097485.1">
        <property type="nucleotide sequence ID" value="XM_022241793.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097486.1">
        <property type="nucleotide sequence ID" value="XM_022241794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYC2"/>
    <dbReference type="GeneID" id="110982964"/>
    <dbReference type="KEGG" id="aplc:110982964"/>
    <dbReference type="OMA" id="ECMDTSE"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14338">
        <property type="entry name" value="UBA_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000154">
        <property type="entry name" value="Serine/threonine-protein kinase SIK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF74">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="22"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="296"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="381"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="794"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="819"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022097484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022097485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022097486.1"/>
        </source>
    </evidence>
    <sequence length="889" mass="100417" checksum="0B3E368E8AB2C5DB" modified="2022-01-19" version="1">MVVMATETQGKPRRGHIRVGFYDIDKTIGKGNFAVVKLAKHRITKSQVAIKIIDKSRLDEANLQKVYREVAIMKMLNNPHIIKLYQVMETKSMLYLVSEYASNGEMFDYLANHGRMTEKEARKKFWQIVNAVQYCHERRVVHRDLKAENLLLDANMNIKIADFGFSNFFTPGDQLATWCGSPPYAAPEVFEGQRYSGPQLDIWSLGVVLYVLVCGALPFDANTLPQLKERVLAGRFRIPFFMSTECEQLIRKMLVIDPAKRYTIEQIKNHKWMQMEGGEPSPVTSPVSDIPKPVGEFNEQALRLMQSLGIDQQRTIESLRRDAYDHYTAIYYLLVERLKLHRCSFPVEGRVDSRSRRPSSISDHAILRTQVIGTGTHIPHVVPGSQQSRSPIKQHSLGSHPTQQQQPIMGFRPVQPASQPAGVKPEAAHAALQRKRKEPILQQPTCIFSEGDVVSVPQVVSGTLLEPLPRMNFRKVRSMSPNHMVVTSIDEGVEVDMPESEGEMDKTPTEQLMAQRRHTLGETFEVTPSMEPTLSDFGIEPQDLSASFDSQEEMEIAQISQGFVQGLGQGMFQLGSGSQRNSPDLSPTVQEQHMIGGPPVGQGITETLLRTGSQSPTSFREGRRASDGLLLQDSFNPQHKNLPRTQGISELHARLDQQQGGEFTDCKIIAEHAKQQQMQQHHGRLLQHMDSVQSTDSGSYSQCQVGQQPVTWRRFPAQVQQNQRQNHFQAMKHTMHTEPAQGTGCSFDELSRGVTPARSLQHHLMQQRLMQKRQQLHKQSQLSQQFQQLHLERQPSFDGRPPPPNRADSYKQAQQHPVLPQFSMKEEPIRSVTPPGTFSQESSHHSNRDASKLHFGLPVTHHSFDNSQFECMDTSEGPTSQSGFSYTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3H4</accession>
    <name>A0A8B7Z3H4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC110984024</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099501.1">
        <property type="nucleotide sequence ID" value="XM_022243809.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099502.1">
        <property type="nucleotide sequence ID" value="XM_022243810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3H4"/>
    <dbReference type="GeneID" id="110984024"/>
    <dbReference type="KEGG" id="aplc:110984024"/>
    <dbReference type="CTD" id="6829"/>
    <dbReference type="OMA" id="YPVGYMN"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06086">
        <property type="entry name" value="KOW_Spt5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000013">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000016">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000017">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000003">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041980">
        <property type="entry name" value="KOW_Spt5_6_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057934">
        <property type="entry name" value="KOW_Spt5_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23288">
        <property type="entry name" value="KOW6_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23287">
        <property type="entry name" value="KOW7_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="13">
        <location>
            <begin position="193"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="610"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="15">
        <location>
            <begin position="780"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="14">
        <location>
            <begin position="1043"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="769"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="779"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="810"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="872"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="915"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022099501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022099502.1"/>
        </source>
    </evidence>
    <sequence length="1096" mass="121055" checksum="2833E14F81AC8D57" modified="2022-01-19" version="1">MSDSDASAFSDVESEGSYQAKSDVEDESPVASEAEEAPSDEGSEVGSMAAGGNEEEEEEEEEGLDLTLPDDEEEDEMYDSEEDDTMTKRKKARFREFILDEADVDNDYEDDEEGDWEEGAKDLIDKTSRVEQDESERHGARRLQQLLSHQKEDEIEEYYKRKYAETSSRSRYADEDELPDQITQQGLLPGVKDPNLWMVRCKIGEEKATAMQLMRKFIAYQYQDEPLQIKSVVAVEGLKGYIYVESFKQTHVKHAIQGVGNLRMGQWNQLMVPIKEMTDVLKVVKEIVALKPKSWVRLKRGVFKDDLAQVDYVEPSQNQVTLKLLPRIDYTRMRGVMRTANPDKRKKKRRPMQKLFDEEAIRAISGEVSKDGDFLIFEGNRYSRKGFLYKTFAMSAIVAEGIKPTLTELERFEDRPEGIDVQLVAETKSSQEQAHSFAPGDNVEVIEGELIHLQGKVITVEGNTISVLPTHEDLKDILEFPASELRKHFKIGDHVKVIAGRYEGDTGLVVRVEENMAVLFSDLTMHEMKVLPKDMQLCQEMSSGVDSLGQFQLGDLVQLDLQTVGVIVRLEKETFQVLNMNNKLVHVKAAAITRKKDSRNAIALDAEQNNIQVKDIVKVIDGPHSGRQGEIKHIYRSFAFLHSRLMTENGGIFVCRTRHIVLAGGSRQMDSGFGIGYTPMSPRISSPAHPSSGGMGNAPMGRGRGRIGRDMEMIGQTVRISQGPYKGHIGIVKDATESTARVELHAMFRTISVDKNRLNRVGGQIRTGATTAYGRTPMYGSQTPMYGSGSKTPVYGSQTPLHDGSRTPHYGSQTPLHDGSQTPGRSGAWDPNITNTPSRSSDYDFSYDEASPSPQPYGATPNPATPGYGSETPPSNGPYTPATPGSSSGMYGSESTYSPYQPTPSPGNYQPTPSPSSASFQQAPSPGSYQPTPSPSSYQPTPSPGGSYQATPSPVGFPMTPGAPSPLGFNPQTPGGGMMGLEGGTAYEWQTTDIEVTIVSHEDQALVKKTGVIRSISGRMCSVYLPDEERVVNVESVHLEPVTPAKMDRVKVIDGDDRDQTGVLISIDNDDGIVKMDGPSDFKILNLRVLAKLHKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z458</accession>
    <name>A0A8B7Z458_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110984172</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110984172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099747.1">
        <property type="nucleotide sequence ID" value="XM_022244055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z458"/>
    <dbReference type="GeneID" id="110984172"/>
    <dbReference type="KEGG" id="aplc:110984172"/>
    <dbReference type="OMA" id="LECEANS"/>
    <dbReference type="OrthoDB" id="6131538at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022099747.1"/>
        </source>
    </evidence>
    <sequence length="148" mass="16861" checksum="A73DC09A7FCBE974" modified="2022-01-19" version="1">MLLWQTMVESSIKQFCEGLGPMYDQVKRSPGATAQLFVYTNNNLRKADLKKTYTITYSLEGSNNRTQEEDTMYSFETFLLECEANSTGVSLSEVLEFWIGAEDIPPYGFQMPLLIDFYSTTPGIRHLPSAHTFMPVLWLPGVLEILMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z686</accession>
    <name>A0A8B7Z686_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Glycerophosphodiester phosphodiesterase domain-containing protein 1-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110984874</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phosphate + N-hexadecanoylethanolamine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:137009"/>
            <dbReference type="ChEBI" id="CHEBI:137017"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:53185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41143"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
            <dbReference type="ChEBI" id="CHEBI:77580"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl) ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71466"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85222"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:56461"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45544"/>
            <dbReference type="ChEBI" id="CHEBI:2700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85223"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:45545"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoylethanolamine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53168"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:71464"/>
            <dbReference type="ChEBI" id="CHEBI:74544"/>
            <dbReference type="ChEBI" id="CHEBI:85217"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:53169"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101153.1">
        <property type="nucleotide sequence ID" value="XM_022245461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z686"/>
    <dbReference type="GeneID" id="110984874"/>
    <dbReference type="CTD" id="284161"/>
    <dbReference type="OMA" id="VHVWTID"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08612">
        <property type="entry name" value="GDPD_GDE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052271">
        <property type="entry name" value="GDPD-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="14">
        <location>
            <begin position="39"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022101153.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38714" checksum="306BD413AEE4793D" modified="2022-01-19" version="1">MSAALIVPLSLIGGYAALSVLLLRFPLLIHRKKQTKINARLIAHRGGAGENLENTLTAYRHALNSGMDMLEIDCQITRDKKIVVSHDNHLERVTGVDRFISDLDYEDLPLICQSIPVHFCKGQTVCGSETDRRIPLLREVFETFPNIPINLDIKRDDDELIHKVLDMIIEYKREDITVVGNFAESVVQKCHQRAPQIPTIMSTRTSVKMLVAFYLGILPFLDFEEEFLEIPMGRELIKNFDVQKRWQKALLWVLDFLLINRVLFGHLQRRGIKVYVWVLNNEAQWDRAMSKRVDGIMTDYPAKLAEYMRRRGYWQDGRAGLRNENYNTFDNGVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6H3</accession>
    <name>A0A8B7Z6H3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Uncharacterized protein LOC110984913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC110984913</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101237.1">
        <property type="nucleotide sequence ID" value="XM_022245545.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101238.1">
        <property type="nucleotide sequence ID" value="XM_022245546.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101239.1">
        <property type="nucleotide sequence ID" value="XM_022245547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6H3"/>
    <dbReference type="GeneID" id="110984913"/>
    <dbReference type="KEGG" id="aplc:110984913"/>
    <dbReference type="CTD" id="138639"/>
    <dbReference type="OMA" id="WSESEMA"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14506">
        <property type="entry name" value="PTP_PTPDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000238">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049573">
        <property type="entry name" value="PTPDC1_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="94"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="165"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="179"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="719"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="758"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="785"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022101237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022101238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022101239.1"/>
        </source>
    </evidence>
    <sequence length="824" mass="91897" checksum="5F5F60AD1C999870" modified="2022-01-19" version="1">MIDHQTTPDNLACHPTDSPDQPSMKSSQNDHQNPSGTHISSIQRPTAKYNRFSNKVRQITPGPLQCAMFCGGKNCKYDNPAKWSESEMALKGLYSSWVGENILAIARPSSEAIEKYRIVEQFKQHGIYSIVNLQRPGEHSSCGNPLQSSGFSYLPEQFMDNNIFFYNFGWDDYGIRSLPSILDMVKVMSFALKEGKVAVHCHAGLGRTGVLIACYLIYEQRMEGDNAIQFVREKRKGAIQTPGQIECCQQFAKFLIPFRVIFSSCDPCAYPFTLDQFLIRQKLMLHGYEARELKYLPKIVRVVCSQLAQLASCTSTSQPQQRRENIDILRKTAPGAFPNQRELANPVQYSPEKRRSDFGYNSLAQPSKLPPLKKRSSSAEDLRQDSARFGSQATLRVPTWPDQTPHRSPMLGLRRHVTDGSVASSSDDDHNAHTETSELAPSQNARFVKSQSKAQAVLEMAPRKSSKGKLASIVNRSVSMLAALRIDDPQDMDDVQLVGTALSFDAASYSVDRDDFNRVLAGLHLRVESLQHNLNRSTSAWEIVSTEEDPFVLSMLMWSWLEHLEKPILSKADIQRLSAEFNEEDPAVAFKNLSRGVKHTMDCILKTVTRLPLQQPHLENLEDSILVRFIKGVTHISAVHLLSEDQPTEELGDDSDDEDNMPLAHLLVMLRAYVQFLRLSGADDTLSLSSQDSSRLSLNDFRSTSFVLRETMTGARAPPYRIQTAPPAEATGGTSPRDTKGREVGETSACSEGIAKAQELGITPRTSPRNQAESHTVPSTSAKLPGERLPRRKLKTVDKPLSKKAENSEALATLPRKNALPPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6P8</accession>
    <name>A0A8B7Z6P8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984958</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022101318.1">
        <property type="nucleotide sequence ID" value="XM_022245626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6P8"/>
    <dbReference type="GeneID" id="110984958"/>
    <dbReference type="KEGG" id="aplc:110984958"/>
    <dbReference type="OMA" id="CKPAKHG"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF48">
        <property type="entry name" value="ECTOINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022101318.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36938" checksum="33E5CF136DC0AABE" modified="2022-01-19" version="1">MTDAMDVQEASGGGVSAGVRCRDLSTVHEPLGGLFKPVKEPADWRHFKLSQEQVDQFWRDGYLTNIPVLSEEQCDKILLDYQRLIEDNDRFPGIDMMYEFHCNQTNDPHNVLLHCLGHWRLTPSFHDVCFIPSIAVPASQLLDPHQERRVRLWHDQLFGKPPHYGGNVAWHQDYSYWTRTTPMAHLTIHIALDAQTLDNGGLQYIPGSHRWTRDGAPLPVTDFNFKDMESIQTILTEDEKVAFKPVHALLKKGEASLHHPLTVHGSKPNRSEYSRRACVVNYIADGVCSNTDEPLLEGTNLIKKGDKMEGQFYPLIYDPAWSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9K3</accession>
    <name>A0A8B7Z9K3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell wall protein DAN4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110985558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102348.1">
        <property type="nucleotide sequence ID" value="XM_022246656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9K3"/>
    <dbReference type="GeneID" id="110985558"/>
    <dbReference type="KEGG" id="aplc:110985558"/>
    <dbReference type="OMA" id="NESCHFR"/>
    <dbReference type="OrthoDB" id="10613836at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050906">
        <property type="entry name" value="Notch_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044:SF420">
        <property type="entry name" value="DELTA AND NOTCH-LIKE EPIDERMAL GROWTH FACTOR-RELATED RECEPTOR ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044">
        <property type="entry name" value="NOTCH LIGAND FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="SEA" evidence="4">
        <location>
            <begin position="519"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="5">
        <location>
            <begin position="635"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022102348.1"/>
        </source>
    </evidence>
    <sequence length="839" mass="91571" checksum="1D6B869A31CE9240" modified="2022-01-19" version="1">MDQLASVRRKEQLLSVLQEEQFLSIPLKELLASVPQKQRVLSLPQTQQPLSVLQKKQRLLVPLKRERLLVLQMVQFLLVQKKEQLLSVTLRDQLALVRRKEQLLSVLQKEQFLSAPLKKQQPSVPQKQQVLPVLQEQQLMLVHQKEQHPLVSLKGQLLNYSRQFRRSNESCHFRRCNNPCQYYRRNNACWYYRWYNSCQYCRSNNSESTTPVSTTEERTPVGTTDGTIPVSTKEGTTPTGTTDRTTTPVRTTDGTTPVGSTEGTGPISTSESPVSSAEATALVSTAEGTTPVGTTNWTSTPVSTTEGTASVGTTDRATNASSTEGAGPVSSAKATTPVSTAEAITSVSTKEGTTPVNTTEGRTPLHTKDVTSQASTKEGTITVSRPTTVARSTDKTIPVSTEGTNPVSSTEGKNPAATTQGSTRARTTAITTILVTTPGCKLSCDNKGVLDAKFCECVCLPGYSGERCEVPPEKNPCSAEPPPCDKEGEYCTVNSTPSGYECLCREADGYVLDKNNCIRKKSFTAKLRVTDINGVGADYEPAYRDIHSQASQELFNQVTPVILETLRNNPATSAVEEVNGVGLAQGSVIVQTAATFSVNSTVTGSLIEKVLKTDALNDGNSTLTLDPEALTVSESTTECPSDFCVNEGKCVKTGYYPQFDYTCSCPGGVSGPNCEIVEGLSPFVIVAIIFGGLAVLVATAVAVFCLCVKTRQEKGVKDLDNADWDFTGLENPELRTTSFSKGEVNGARREEDPWAPRGVLDVLSPEEEQRMSQIAEVMARPPQEIQRSGYNDQRTSLYQWQSIPLPRARIYRQQEVLPVRIEMNDNDGGRRARYHFSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9T4</accession>
    <name>A0A8B7Z9T4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110985190</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101727.1">
        <property type="nucleotide sequence ID" value="XM_022246035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9T4"/>
    <dbReference type="GeneID" id="110985190"/>
    <dbReference type="KEGG" id="aplc:110985190"/>
    <dbReference type="OMA" id="TSARWIQ"/>
    <dbReference type="OrthoDB" id="6128227at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052751">
        <property type="entry name" value="Plant_MAPKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011:SF4">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="863"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="745"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="893"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101727.1"/>
        </source>
    </evidence>
    <sequence length="1125" mass="123180" checksum="98BDF3E73CA9F4CD" modified="2022-01-19" version="1">MFNFAAAFSERIRYSRSTKVVRFVPDDDGGSSPEPAHGGGGEIPRCRDGNSPASLDDDYGLTSARWIQSRGDTGVRSTITGQTSGQAPLQVSQGRVSGDSAQDQQNPNKPQEGLPLKSLLPHKKFWRYRRTKVRPMVASVSRSAQRPHLAAEDSGDGMLLTSLAAPSSSERSQQIIALKSCQATTDIDLRSSGSPLAAKDNLSPTIKRRPDLPSNSKSQLSWTTRLRNLFTSRKHRSATAVVPFQAAGASAEWRPDELMNKPSAPEPKSDKSVALKTKIDERRFEADGVSRVPHHWQTSANVTTRATLLDTAPMPLPGVPQFDGECQHSSPPAPRICSTSPRESPSSSEHSVSSKPSILRPASRLSCQQGAVMTSGDRASKGGDSIFSPPSPPTRDDPLSSPSLPSLRQSREAASEEGDGALGDRRSISKQPHPPSPKSKVTPSSQGSLSSIQKKQEAVEQGGNGTPTTRGGLISKPALVKSKRTPGFQEQKGVHVRKLEKHYYQTMWANTEQSLSQPPPVQNMTPNVTNGVKMRERALKRVEQVALKIDVSFIYANLEAAKVTSPQCRWVDVLQRIIQRSQELRQMRLEKKQVPYTSEEIRGIELNAYRAREKLYLLKQMITAASFVQAQPGEERRRFFHHICNTPPDLKRSQATLSEKTTTQTSNEPSRAPRKCAPGQNQAILAIISKETASKNPKSRILERKGPATEIAPSREQGTESLQISPLQIFKRMTHKKLRRCIKEKTIKAQTSDSNSRPASPLTTPKSCSSEQKKSLPPTMLRKSSPGASSQIPRKTSSPNNTPSGLSTRKSPSKTMSVASISPSKTTHPKIAPSCLKKILPGHLQGPYPTVDSGDLEYVMTSSGSKVVLGRGDNGEVLLMRRHGDGTLLAVKKLSNNRFRITVDKHMLREVAAMQAVSSCPFFPKLFGVVDNSSFAQEFLGDESTNLAMDFAAARFSHGLLTAREWLNVCRDVTEGLKVLHRTGWVHNDLHVGNAMLCKSPPGSKIGWTAKIIDLGLAHPLQNLPPAYNLTHEEKQCYYQMCKQVAPEIVEGKTQFSTKSDIYSLGKLFKDIAYNSSSLHGLRHLGLACMIRNPAHRPTLNTVLKKLDGLCSKVAKSKLPPLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAW7</accession>
    <name>A0A8B7ZAW7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102117.1">
        <property type="nucleotide sequence ID" value="XM_022246425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAW7"/>
    <dbReference type="GeneID" id="110985416"/>
    <dbReference type="KEGG" id="aplc:110985416"/>
    <dbReference type="OMA" id="ATIAHCI"/>
    <dbReference type="OrthoDB" id="10070532at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF13">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034735948" evidence="1">
        <location>
            <begin position="19"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102117.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19316" checksum="C5EC013AEA7DE4E2" modified="2022-01-19" version="1">MDKSLLLLLLVAVATSYAQKKCCFPNQFEGSVGTLTGTVMGGQGSVTNAVHQYAFDYTNKRLATIAYKENMGQQTKYQNIFDYNKEIEYEIQILPQISVCLVHHLPPGTNMTHSIPDSAAYLGSSYYGNHQLNVDIFQYYQPKGDFVGNVTITVSQEECVPISLVQQGQNNNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBJ1</accession>
    <name>A0A8B7ZBJ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein N-terminal asparagine amidohydrolase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110985459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102190.1">
        <property type="nucleotide sequence ID" value="XM_022246498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBJ1"/>
    <dbReference type="GeneID" id="110985459"/>
    <dbReference type="KEGG" id="aplc:110985459"/>
    <dbReference type="CTD" id="123803"/>
    <dbReference type="OMA" id="WRETFPM"/>
    <dbReference type="OrthoDB" id="539995at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026750">
        <property type="entry name" value="NTAN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498">
        <property type="entry name" value="N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14736">
        <property type="entry name" value="N_Asn_amidohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022102190.1"/>
        </source>
    </evidence>
    <sequence length="310" mass="34617" checksum="68842486288A99D4" modified="2022-01-19" version="1">MPLNYCDGSRLCAQCRVEDLEEVIYLKYGDSSKLLRSQPVRSCLPPSLLYVDQRELAVTTVHDDVINTLGSDDATTCHIAVLRHSGSGATGLCHFDSCGTTQGVQDLVDKVRELSQDIDGRLELHIVGGFKDDDGSSEKLSRKLLSEFHKLSVDVFLLTACISDLNNVTKSGENYPAICGLGVSVKTGEIFPASFAYKGPDKPVRSLRHFIGDKDIKNIYDHTDHRLRISPYSYTPNDFPHAALFLRQSDQTIRQYMSTSPAVEPEHFAQQVRAAITFFLSNPSSEMVFPGGRSHFFKMRQDGHWQLDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC45</accession>
    <name>A0A8B7ZC45_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110985669</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102547.1">
        <property type="nucleotide sequence ID" value="XM_022246855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZC45"/>
    <dbReference type="GeneID" id="110985669"/>
    <dbReference type="KEGG" id="aplc:110985669"/>
    <dbReference type="OMA" id="NEWANSN"/>
    <dbReference type="OrthoDB" id="6142777at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034144003" evidence="1">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102547.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="16370" checksum="A7F51053C6CDD689" modified="2022-01-19" version="1">MKYIAVLLVLLGAFAYLHKAEAVTGQSIANVALGYVGSTRWALTSSTWPGTNTNKCNIFVATVLEEAGASVPQRHWWTWSPIGANEWANSNSNYLTSSSCWTSGSGGIGNVAALGGHVGIVTSSSQTTSATATAVVTNDWGFRSGQSPVFWEYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCU7</accession>
    <name>A0A8B7ZCU7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102670.1">
        <property type="nucleotide sequence ID" value="XM_022246978.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985739"/>
    <dbReference type="KEGG" id="aplc:110985739"/>
    <dbReference type="OMA" id="ACYFANS"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102670.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="35877" checksum="9DC73DF63F376494" modified="2022-01-19" version="1">MWVRGAVQVAILKGLGMMLPTLRDQFKTTASVVGWMTSMIVAVGGVVAVTAAPLGRRFGAGNVIMVCGIMIGVSFIVGSYATTPIQLLLALTVLAGSALRVPLVLSKEALGRGYHKKHALATGIAKTGSSVGLAVVAPLIQLCLSTYGWRGTMLMISGISLHLVPCGALMRSVRKAPSTRYQELPQDEVSLVNSVPRTDCTSCWTSVFNNFDLSLLCNIRYWLLAFVVFSFTFTYEMWVIYFVSHAVSKGYSLDDAAVFVTVAGFGNLIAKVLQGFIVEAGIISTWGLMVICILVSSSGFLATPLLSWYWAMMLTSSMVVVCSGVLYCLQDVLX</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDQ7</accession>
    <name>A0A8B7ZDQ7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium channel subfamily K member 16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110986330</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103808.1">
        <property type="nucleotide sequence ID" value="XM_022248116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDQ7"/>
    <dbReference type="GeneID" id="110986330"/>
    <dbReference type="KEGG" id="aplc:110986330"/>
    <dbReference type="OMA" id="WIFLVMI"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF330">
        <property type="entry name" value="POTASSIUM CHANNEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="88"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="181"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022103808.1"/>
        </source>
    </evidence>
    <sequence length="381" mass="43062" checksum="4FB26DD745EBD9B0" modified="2022-01-19" version="1">MKAWLKSLILIPIFIVYIFLGAYVFHKLEEGNAAAEREEFFKFLIPFAINHSDCLSSDALLSVLDRASEARAKGVMYPSQVLAGQLVGFWSWSNAVVFAATIVTTVGYGRLVPITAVGQIVCIFYAIFGIPLCYKMLSVVGDTFHSLWHHSFRLFDRAAACVKSQRTRKVLGVLVTCLVLWIFLVMIPAVIFANTESWSLVDAQYFSFVSLSTIGFGDIIYGMEDRLATVKQDWLYKIGMLVYFLIGLSVISIVFKGVWRVQKARIKRAQKTTRQFWQNRGGRHRNYSLGTPEAIDEALLANGLFTRKRSGDVVEPVFEKHSAGDDEEIDKTMAMDAMEVRDRKISIISLSYRTVSLRQNLADRDLRHGLCNTSFLEEVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE46</accession>
    <name>A0A8B7ZE46_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110986399</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110986399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103938.1">
        <property type="nucleotide sequence ID" value="XM_022248246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE46"/>
    <dbReference type="GeneID" id="110986399"/>
    <dbReference type="KEGG" id="aplc:110986399"/>
    <dbReference type="OMA" id="MECNANN"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="569"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="606"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="639"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="729"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="89"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022103938.1"/>
        </source>
    </evidence>
    <sequence length="779" mass="81900" checksum="BF683E34BB3FCAA1" modified="2022-01-19" version="1">MSVPCQAGMPVAPPELPTVQPDLVSNAAGDAQGCCRQPAGPAGPDKLDGLDLAEVITSIPLAGSNVPASSPATSVHPKNLDRGWAWLIMIAALFTHILTFGMSYATLGAFHVELLREFGGTNAETSWTGSIMLGMMLCSGPMISVFIDKFGACAVAVVGGALASAGFILSATATSLIHLYFSFGVLAGLGFGMSYLPCIVMLGNFFERRRAFAAGISASGSGLGTFIFAPVNQSLLANLGWRNSFIVLGVLELMLCLCGATYLARKIPVRVSGAEGDRDINVDNSATDGDGMAQEHTEQTVAILSRPETGASAQSLNSPVGSWKQSIGVKVGRSVLLQSPRNSPVPASPYLLDSFFGLPSPSAANNVRGRSLANNSSSVGESGSRISPAGPLPAIEIVHASSPPSPVHSPTAYSPNPGGFTIGSWQQSVNVRAGVSSFLQSPITSPTAGSPLATDNSFRDNNSRLSVPSALEASQDPSAPGSLNQLPTTTLLECLPEEERLYPVLGDLTDNASGVSVTSIEAGLRDDLEEGSSQKDTDNEDASNVTPTRNCQECLSTLTTIGGLFRNRFFVFFWFSGFILCIGYQLPYMYFKAFALSRGLEQDAWAVILAVMGITDTVGRLVVGFIFDRVMCVSHRLMGYVASLFISCFLLALMSTASTYSTLALTAATYTLVAGSTDPLVPALLVEYVGLESLGYSFGLVIEMQGLGFLVGPPLAGFVYAHIQDYSAVYVVGAIAFLGSGVVLLLEPILGRVQTWRERSRHNNSVESPVSVEMAQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF93</accession>
    <name>A0A8B7ZF93_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110986606 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110986606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TM2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104294.1">
        <property type="nucleotide sequence ID" value="XM_022248602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZF93"/>
    <dbReference type="GeneID" id="110986606"/>
    <dbReference type="KEGG" id="aplc:110986606"/>
    <dbReference type="OMA" id="IWEHEIA"/>
    <dbReference type="OrthoDB" id="10262359at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007829">
        <property type="entry name" value="TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050932">
        <property type="entry name" value="TM2D1-3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016">
        <property type="entry name" value="BETA-AMYLOID BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21016:SF25">
        <property type="entry name" value="TM2 DOMAIN-CONTAINING PROTEIN DDB_G0277895-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05154">
        <property type="entry name" value="TM2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="8">
        <location>
            <begin position="73"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="8">
        <location>
            <begin position="167"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="TM2" evidence="8">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022104294.1"/>
        </source>
    </evidence>
    <sequence length="422" mass="47890" checksum="98D3673AA91D5F64" modified="2022-01-19" version="1">MASERSHLLACTTGSSDDGAGPSRMATPQASQHSLLPTNTTQSAGESRVPPPRGPEEAQPPRSVPPVPKTMLKTVVNAYIMWFPFGLLGFHHFYLKNASFGFKYLITFGLFGFGWLVDFWRMPMLVNAANMEIEAKWIWEHEICETMTGDEIPRFKYEKPKRLSDCYLLGFTTGFLGFHHHYLGRHVLGLVYLCTLGLLTVGFVSDWIRMPIHLKRYNERRAKEIQGIKEPQMYYLDDAYILAVPGGILGFHNFYLGRYFWGFVYLLTLGLLGMGWVMDLIRMPLLVQEANLRAKSGRSMFDGIEQGTKYRSTEDEVPRIDPYYSDYNSTHSHPSLSHSDTPARTVTAPHRNRILRPASQRPVPKPRHFKEFRSSDEFEPATSSQPEDFDLPPHSQGLSEPPPPYVSVADPGSALQNDETNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFI5</accession>
    <name>A0A8B7ZFI5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110985337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosyl cyclase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101991.1">
        <property type="nucleotide sequence ID" value="XM_022246299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFI5"/>
    <dbReference type="GeneID" id="110985337"/>
    <dbReference type="KEGG" id="aplc:110985337"/>
    <dbReference type="OMA" id="SCQTCAN"/>
    <dbReference type="OrthoDB" id="10028716at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016849">
        <property type="term" value="F:phosphorus-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04759">
        <property type="entry name" value="Rib_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.82.10">
        <property type="entry name" value="ADP Ribosyl Cyclase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003193">
        <property type="entry name" value="ADP-ribosyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912:SF7">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02267">
        <property type="entry name" value="Rib_hydrolayse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034335727" evidence="6">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022101991.1"/>
        </source>
    </evidence>
    <sequence length="284" mass="31168" checksum="8257C7F1C4DDE66C" modified="2022-01-19" version="1">MLSQSALSMLLDLLVSISLGQHTGKGSTLNLKEIVVGRCWDYQRVIGMEPGRPHNPVDCAKAWAVFTDAFAHKDPCETPPDAFSQFAHMMTVSLPKDGTMFWSGTKDVALTISSLSHGSNFSLENTLLGYTVNGLTWCGKETVNGDGINYDNCPSFDDPNCRSSVSSVFWTEASKTFAMQATGSVDVFLNGSDPRGAFRENSFFATVELPNLNTALVNRVNIIVIHNLYGPVIDTCGTGTILTLQSRIEDRGMDWSCDDDPEETKIIQCLQYPHSYECELGNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFS2</accession>
    <name>A0A8B7ZFS2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Fatty acid desaturase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110985398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102086.1">
        <property type="nucleotide sequence ID" value="XM_022246394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFS2"/>
    <dbReference type="GeneID" id="110985398"/>
    <dbReference type="KEGG" id="aplc:110985398"/>
    <dbReference type="OMA" id="IQEFSWC"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000007">
        <property type="entry name" value="Sulfite oxidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF88">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE FAT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="12">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022102086.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="51949" checksum="E9891257F133C92F" modified="2022-01-19" version="1">MGKGQERQTSMRVSKQSTYTWDEVRQHSTQTDKWVVIEGGVYDVSQWVKRHPGGFKVLSHYAGEDATEAFVAFHPDKNLVRKYLKPLYIGSLEQDNQPKKSFVTDMQALRLKVEQRGLLETNPWFFAAVMAHILAFEVLGWFVLWYYGTGWVPYLTASVLLLLAQGQAGWFQHDLGHLTVFKKSRWNHLLHGFILGGLKGSSAHWWNYRHFQHHAKPNIVFKDPDIRMEYLFMLGDKMPVRWANRKKGFMPYNYQQSYFFFILPPLLLPVYFHYEYFAHVIKKKIWIDLAWMVFFFGKLFLTYGPLLGLSGTFWLYMFIRFMESHWFVWVTQMNHIPMEIDSDKHKEWLPMQLQATCNVEPSWFNSWFTGHLNYQIEHHLFPTMPRHNFYKVAPDVQALCRKHGIPYQTKPLFTAMADIVRSLKRSGKIWHDAYYHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGN8</accession>
    <name>A0A8B7ZGN8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Paired box protein Pax-5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110986462</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022104030.1">
        <property type="nucleotide sequence ID" value="XM_022248338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGN8"/>
    <dbReference type="GeneID" id="110986462"/>
    <dbReference type="KEGG" id="aplc:110986462"/>
    <dbReference type="OMA" id="DCVRARI"/>
    <dbReference type="OrthoDB" id="3225452at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00131">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000013">
        <property type="entry name" value="Paired box 8 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000003">
        <property type="entry name" value="Paired box protein Pax-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043182">
        <property type="entry name" value="PAIRED_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001523">
        <property type="entry name" value="Paired_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043565">
        <property type="entry name" value="PAX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636:SF43">
        <property type="entry name" value="PAIRED BOX POX-NEURO PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45636">
        <property type="entry name" value="PAIRED BOX PROTEIN PAX-6-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00292">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00027">
        <property type="entry name" value="PAIREDBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00351">
        <property type="entry name" value="PAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00034">
        <property type="entry name" value="PAIRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51057">
        <property type="entry name" value="PAIRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0563">Paired box</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Paired" evidence="9">
        <location>
            <begin position="5"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022104030.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="37728" checksum="5C3BD0E3CDA99F0B" modified="2022-01-19" version="1">MPHTGQAGVNQLGGVFVNGRPLPDCVRARIIQLAQLGVRPCDISRQLLVSHGCVSKILTRFFETGSIRPGNIGGSKPKVATPLVVKKIMGYKHDNPSIFAWEIRDRLLQERVCDENTIPSVSSINRILRNSAPNGVGGEMTTNLPAPVARLPAPVPQRPSPQIAGQLAFKAPSAAKPSHSIDQILQGNEGRKRKLSCDSEEDDENQTSEKISKTEASAPTSPARIVSPPVSSTLKTPPPTPGGCPTSSDIVLLPTAPLQQNAPAEVGGAICPFPSAKVCLTGLPKLPVVTSSTLPAASSIIPGGAAVAQALAAIGGFSFAGLSGGMLPLRASGPVSTAPVSYPALAMALQSGWAYRSMKAQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZK84</accession>
    <name>A0A8B7ZK84_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centromere protein C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Centromere autoantigen C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Centromere protein C 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987216</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX. Interacts with DNMT3B. Interacts directly with CENPA. Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Interacts with MEIKIN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105447.1">
        <property type="nucleotide sequence ID" value="XM_022249755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZK84"/>
    <dbReference type="GeneID" id="110987216"/>
    <dbReference type="KEGG" id="aplc:110987216"/>
    <dbReference type="OMA" id="NDTMEIH"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="10">
        <location>
            <begin position="41"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105447.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="14160" checksum="7BD6EC02F7002B33" modified="2022-01-19" version="1">MVVMNPDTQQEVEVDTLRTAKMNVFVGPSGKEATADDPITLCKSISQKAFASGILTIRPLQEKGLQFVRNDTMVFYITRGKVSVTIHHTTSILQTGDMFFVPQGNMYNIKNLRHDEAKLVFFQHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM66</accession>
    <name>A0A8B7ZM66_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">Small conductance calcium-activated potassium channel protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17" type="primary">LOC110987762</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106508.1">
        <property type="nucleotide sequence ID" value="XM_022250816.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106519.1">
        <property type="nucleotide sequence ID" value="XM_022250827.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106527.1">
        <property type="nucleotide sequence ID" value="XM_022250835.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106534.1">
        <property type="nucleotide sequence ID" value="XM_022250842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM66"/>
    <dbReference type="GeneID" id="110987762"/>
    <dbReference type="KEGG" id="aplc:110987762"/>
    <dbReference type="OrthoDB" id="73653at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016286">
        <property type="term" value="F:small conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000022">
        <property type="entry name" value="Small conductance calcium-activated potassium channel, isoform O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000027">
        <property type="entry name" value="Small conductance calcium-activated potassium channel, isoform O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004178">
        <property type="entry name" value="CaM-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036122">
        <property type="entry name" value="CaM-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015449">
        <property type="entry name" value="K_chnl_Ca-activ_SK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10153">
        <property type="entry name" value="SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02888">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03530">
        <property type="entry name" value="SK_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01451">
        <property type="entry name" value="SKCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM01053">
        <property type="entry name" value="CaMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81327">
        <property type="entry name" value="Small-conductance potassium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin-binding" evidence="12">
        <location>
            <begin position="529"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="693"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="641"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="776"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="791"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022106519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022106527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022106534.1"/>
        </source>
    </evidence>
    <sequence length="807" mass="90699" checksum="0C8EAB110A836679" modified="2022-01-19" version="1">MAVVMVSPANEQSCIDSTEQLLCQTEETTAACAGVLAPSSGNRTDPTATADKDNQQQLHEAAGSTMDYHGRGGGWEPLCSHHAAEEYELQARDGSGSTPDSPQTTAHTGLLEKADKDDTHDSASKEELFFIGGSTGGKQPHRGQSSASSSGRRPAQKRRHLAEPSSDNRFVNLAHRSALVNGTIPRFTPLQLHRSERSWARSSVADMKGNGSAEGSSRKSSGGGGKKKTHYSHANTGYRLGLRRSLFERRKQLSDYALVIAMFGIVVMIVETELSWFFYSKESVYSYILKAFISFSTIVLLVLIVLYHAREIQLFLVDNCADEWRIAMTWSRISLITCELFVCVIHPVPGRYFFEWVAEFAYTHEPRTAIADVDILLSIPMFLRLYLICRVMLLHSKLFTDASSRSIGALNRINFNTRFVLKTLMTIFPGTVLLVFTVTLWIIASWILHVCERYHDEDNGEILNAMWIVSITFLSIGYGDMVPNTYCGRGVSVITGIMGAGCTALVVAVLATKLELSRAEKHVHNFMMDTQLTKRLKNAAANVLRETWLIYKYTKLVKNVSSRRIRKHQRKFLSAIHKLRKTKLDQRKLADEASTVVDMAKPLLVRASRAEMAMYTSKPPVLYVHTQNVMFEMVSDMHASRSGIDERVSRLEQKLERLQTTLEDLPQILNSFLENAQQQMLQSQQQYLLLQQQHMQQQQQQPQQPQQPTPKEEPPQRRQTLQVQKHVEESPPLVHSSGNPFVLEVTPDSTAPSEPAKSLRLRSFPAQGASASFEESTLRRDLEREVERSRAYSSPDVSNSRIPNAHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZN65</accession>
    <name>A0A8B7ZN65_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110986861</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104816.1">
        <property type="nucleotide sequence ID" value="XM_022249124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZN65"/>
    <dbReference type="GeneID" id="110986861"/>
    <dbReference type="KEGG" id="aplc:110986861"/>
    <dbReference type="OMA" id="APRCTCM"/>
    <dbReference type="OrthoDB" id="10386155at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022104816.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="41523" checksum="F777307F90AB54B6" modified="2022-01-19" version="1">MNRAVQHPPQSGRNTPNDGFFDSRHFMELDYIQHRAERRRKEAAREEFLSAQRQRTEEKPLRASTEGESQDEGPEVKQSCQFCRRAAAQPVFRDDTSTFKALRRPLAPRCTCMDPTDGGLPILPIEYPVDIDDWADKPFSTIASGGALGYRDLFPLLMQRCTEAEEKDTTQVQTETRRHSIVTTDYLTGMIKLEGTGGEHVHMNVFPVLHVVVSSDEDDDEGSPLDSTDRSELATTPDDALCSPRTDHGLVSPRRPSVQFPATQRRSSLTPSGYSGRASISPGAARSRVIRRRSVDHGSLALSFARALEAASDAMTPISEGREGQNETAGEDFDVKHAEETMIQMAQNLQTLEEFLEGSSSNSSVSDTSSDNDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP07</accession>
    <name>A0A8B7ZP07_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP-glucuronosyltransferase 2B1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110988275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107323.1">
        <property type="nucleotide sequence ID" value="XM_022251631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP07"/>
    <dbReference type="GeneID" id="110988275"/>
    <dbReference type="KEGG" id="aplc:110988275"/>
    <dbReference type="OMA" id="RFLFCKR"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF145">
        <property type="entry name" value="FI06409P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022107323.1"/>
        </source>
    </evidence>
    <sequence length="180" mass="20540" checksum="0151C3B5B548C256" modified="2022-01-19" version="1">MQTQPKKGINARRHNKTKLFMYHGGINGAYEAIYHGVPVVGIPLFADQIDNLLRLWSLGMAEYVKGGIREVNSDTLYQLIMKVVSNPSYKRHAVAASERYRAQPQKPLEKATFWINHVLNHGAEHLRTKSRELSWIQYHMLDVAGVLAIPFVLFIWGVRFCLSALCCRAKSAGQQYNTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPQ3</accession>
    <name>A0A8B7ZPQ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nociceptin receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110988321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107389.1">
        <property type="nucleotide sequence ID" value="XM_022251697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPQ3"/>
    <dbReference type="GeneID" id="110988321"/>
    <dbReference type="KEGG" id="aplc:110988321"/>
    <dbReference type="OMA" id="FICHAPF"/>
    <dbReference type="OrthoDB" id="5987936at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="52"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022107389.1"/>
        </source>
    </evidence>
    <sequence length="412" mass="44970" checksum="3F92C2446DD74B4D" modified="2022-01-19" version="1">MGANVQTISPCDAHVNLTDADEETLSQWMYSDTRIQISIASRSIILVVGVVGNGAFLIVIARVRSMHTLVNFYLVNLALADGLVLLQHAAVPIINYSLLGIPSDGNLLGSPGCMVTQFFNYLGYFTSIFLVCLMSTERYLAVCHPLRHLSINTKSRASKLVACAWALGILLSACAIPVNAVYTKYCIQWPEGGRYDSLPTSAGRCAPTVDWASYAFDTIHAVPFFSALVCNALFFIKIVRNLRRRQAIDRGRGSLQGRRMVHITHQVTKMLAANAVVFFICHAPFQFLSLCILVSTLASLPLFADPVVQGIVVTTSRILVYVNSAINPIIYNATNSRYRRAFIRVFACSSPARREAAHSTIMAPGDATIVATDRSVEDRLDDDKGGQTSNGSLLLNGTPSDGVSQRSHHTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPS7</accession>
    <name>A0A8B7ZPS7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Ascorbate transporter, chloroplastic-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11" type="primary">LOC110987203</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105419.1">
        <property type="nucleotide sequence ID" value="XM_022249727.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105420.1">
        <property type="nucleotide sequence ID" value="XM_022249728.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105421.1">
        <property type="nucleotide sequence ID" value="XM_022249729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPS7"/>
    <dbReference type="GeneID" id="110987203"/>
    <dbReference type="KEGG" id="aplc:110987203"/>
    <dbReference type="OMA" id="FYKHPKD"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015291">
        <property type="term" value="F:secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000452">
        <property type="entry name" value="sialin-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022105419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022105420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022105421.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="47468" checksum="5BDB18F75936E205" modified="2022-01-19" version="1">MKLPLRPQQQEPLTETGDGPRSQTLPHRCCSMASTPKISSSKIVALCSMANFINAADRVIMPIAVVPMTDQYHWNMGVQGWILSAFAYGYISSQVIGGKAALKFGGRMTLGLAVTVWSLATFMTPALAKTVNLLIMSRILLGFAEGFCLPTIFHIFAQHVPVEERSRAFGYLVALGSVGQTVASVICPHLSWPMMFYTFGCIGLVWAAIWILLFRDESPDVDPQLLYNPTLDTTNSVRWTSYISHRPLWAIYAAHFAMNWSNYIVLSWLPTYLQRHLGANAKDISFTALPYIMNSLVGVVAGHYADSLISKKYWTVLSVRRLMTSIGLIGPSLFLLCFSYVDSLALAVCFVSISLGLCGCNSSGHMSNHPDVAPNHAGITFAVSNTLATLPGLACGPVTALVVGSTGYWYPVFVMASAVNIGGALIYISQSSASQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPY6</accession>
    <name>A0A8B7ZPY6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110988054</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106965.1">
        <property type="nucleotide sequence ID" value="XM_022251273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPY6"/>
    <dbReference type="GeneID" id="110988054"/>
    <dbReference type="KEGG" id="aplc:110988054"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022106965.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16857" checksum="F9037D73A3673D5F" modified="2022-01-19" version="1">MIPESSSVESTHATSAPATISRPGGSSAQTLEPELAPAKPTVWVIGDGSVCWCAQVAGSSPRGERLNRLAYIHWKGPRRLQMFQFSDFLLEAWSAVPILPDVIILQFGANDLGLVHKHLLSILARQCINLTREVLPHTVIFYSELLPAKLTFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZR65</accession>
    <name>A0A8B7ZR65_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vitamin-K-epoxide reductase (warfarin-sensitive)</fullName>
            <ecNumber evidence="3">1.17.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110988312</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.4" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022107375.1">
        <property type="nucleotide sequence ID" value="XM_022251683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZR65"/>
    <dbReference type="GeneID" id="110988312"/>
    <dbReference type="KEGG" id="aplc:110988312"/>
    <dbReference type="OMA" id="YVINFAL"/>
    <dbReference type="OrthoDB" id="17010at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047057">
        <property type="term" value="F:vitamin-K-epoxide reductase (warfarin-sensitive) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12917">
        <property type="entry name" value="VKOR_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.130:FF:000001">
        <property type="entry name" value="Vitamin K epoxide reductase complex subunit 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042406">
        <property type="entry name" value="VKORC1/VKORC1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519:SF8">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="13">
        <location>
            <begin position="17"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022107375.1"/>
        </source>
    </evidence>
    <sequence length="177" mass="19592" checksum="852F0479ED1EB9E6" modified="2022-01-19" version="1">MGNPNSAAATTGKIQMPISHRLARWGLCFIGTVLSVYALYVETSKEANPQYKAMCDIGESMSCSKVFTSKYGRGFGILGSILGDHHILNQPNCFLGVIFYILQVAIAKIHTLAATNFLLMTSILSNVGSVYLAYILYFVLEDFCLVCVSTYIVNALLLGVNVLKWKYLSRMLSKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRV9</accession>
    <name>A0A8B7ZRV9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Microtubule-associated protein 1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110988682</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108134.1">
        <property type="nucleotide sequence ID" value="XM_022252442.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988682"/>
    <dbReference type="KEGG" id="aplc:110988682"/>
    <dbReference type="OMA" id="DEMMTPR"/>
    <dbReference type="OrthoDB" id="5371837at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031114">
        <property type="term" value="P:regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026074">
        <property type="entry name" value="MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057480">
        <property type="entry name" value="MAP1A/B/S-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056617">
        <property type="entry name" value="MAP1B/S_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843:SF12">
        <property type="entry name" value="ATPASE F1_V1_A1 COMPLEX ALPHA_BETA SUBUNIT NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13843">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23415">
        <property type="entry name" value="MAPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25281">
        <property type="entry name" value="MBL_MAP1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microtubule-associated protein 1B/S N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Microtubule-associated protein 1A/B/S-like MBL-like" evidence="3">
        <location>
            <begin position="223"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1446"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1016"/>
        </location>
    </feature>
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        <location>
            <begin position="1074"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1097"/>
            <end position="1113"/>
        </location>
    </feature>
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        <location>
            <begin position="1172"/>
            <end position="1185"/>
        </location>
    </feature>
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            <begin position="1186"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1255"/>
        </location>
    </feature>
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            <begin position="1342"/>
            <end position="1355"/>
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    </feature>
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            <begin position="1386"/>
            <end position="1395"/>
        </location>
    </feature>
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            <begin position="1449"/>
            <end position="1458"/>
        </location>
    </feature>
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            <begin position="1459"/>
            <end position="1474"/>
        </location>
    </feature>
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            <begin position="1475"/>
            <end position="1501"/>
        </location>
    </feature>
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        <location>
            <begin position="1605"/>
            <end position="1638"/>
        </location>
    </feature>
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        <location>
            <begin position="1701"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1760"/>
            <end position="1773"/>
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            <begin position="1774"/>
            <end position="1785"/>
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            <begin position="1807"/>
            <end position="1832"/>
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    </feature>
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            <begin position="1833"/>
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    </feature>
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            <begin position="1854"/>
            <end position="1863"/>
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    </feature>
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        <location>
            <begin position="1864"/>
            <end position="1876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022108134.1"/>
        </source>
    </evidence>
    <sequence length="2002" mass="217137" checksum="FEC4CC98E6C915F8" modified="2022-01-19" version="1">MANELPDGLGSESTCISGSFSSEITHYLLVVVGEPLSQEYVDPALADVEKALQCWDVDDSAIGYDSVLQATAAADVHKVGLVHRSLAHCGTSVGVVILVNPTSGEVTAELRNLLIHPASNKHLIFGGHWLEGSGDWVLHNDTFTLHDIAAIFSEPEVDAAVLKASQDDRQTLVVSGCRWQTAAVTKQTFTKSLNLTINPQEVKNAMAGISLVLQTIRNNIQIPSPFELLEPPTMGVGVKCKITKPTVLIFPAGKGDCAFFAVTDFSIFLGGGYCTKSCFWKFAKHLHRIDAIMAQHMQPDSLVGFNSLLKRKIAEQQLTEPEKGSEEHEDWLIKCNSPEVGVVYLNAPENKKSATSLQLKTVSQGNLTQQLLQELEIKPFSCTANIGKIIEPVTLYQKVGIGRLDMFILTPVHDSKELKDFMQQWSGNKAFSKVKIGMKVNGKESEYPISSAVSICALIVWQPANPHEDIVKVLFPGNAPQTKILEGLDRLKHLDYLKYPHVTAAKLTKGGAPLKKKSPTAGGKTPPKANGPTASVTVTSSNEATCTDGIHCGTPPPEVQGECTDGKNCNTPPPCPDGLCCGTPPPDGKCKDGLGCNTPPPDTEEGSGVCSDGKNCNTPPPEESDGQCCDGKHCGTPPPENEYDEDACNKFVPIEPYKCTDGANCNTPPPEGDVMFTDGNHCSTPPPEDDGVMDTQESPVDNEPQATVQGDICGNLMDSNLPESQQDMGAFVYVGTPDAFDNKQSDAPERLASGEITPSDQVEYGDESPNDGSFVFEAEAGSKVPAPVPSGFGDYAEEDHVEAAAPGEFGGGFEKKRDLSDDESPTNGNQGSGAFDDESGSPNGGPHPWEPRIEFSSPDQEPDDSYLVEEPRPEADFHEEQIKQASFPEIPPPVVPSNGGSAVEEMEAQASSQEYAQGIQYEQQEDIAEDEEEDSSEASQASEIEVKPDQQLAEAENQMMYEEPAPVSQMMPEDSQVAEDGRSEEQGQIPDVEGNVVEMEAKDQEISGQFDVTSEEPQPVQGLGDEENQYVMQPDVQQVTEQEVAAGESEQLQAEIRGEPVVEIQSSEGQEEVLAGREEEEHEEMETGHAESVESPAPEEDQDQVVPEGEYEEYVPPPDVPVTEAWSQEGQQEINQNFMIPDEFSGGRVQESLQPEEMGSQLAEISPEAEEISPKAEEISPKAEEISPEAEEISPDAEEISPEAEEISPDTEEISPEAEEISPEAEEISPDSGEISPDAEAISPEAEDISPDAEDISPQPEDFSPQPDDISPQPEKISPLPEEVSPQPEEISQEPGENSQHPEEISLQPEADINENRQIAVEEVMLLEETSLQPEAEAVLESSERDSEDLVHFGDEVPPSEPASHPYQSEDMEQAAQEHPQVIEREPEEGPETVEEYSPFEAQDVPSTLISEPVSDTFTQLPVPAQEAQQEIIGEPVSDYDVEAAYNQEVIQEESSIPDQQSSSEPLLDSLSEPQSEKEPDSLSEPHIDVEFEEEATKGEVEPVEMSAPAQEPSLSEPHIDVEFEEEATKEEVEPVEMSAPVQEPSPSEPEPEPIKEPSPQPSPELQHEPVVEPSPQPTPESQLEPQPLMGATEQSAEPEPEPKPAAVPEIAAKAASSVSTTTKVTTKTSTTTSSATKKPADKGAKTKGTTKTTTRDIKTTTKTKTSVVTEKKSTTKTPGTKKLEVTGAAKRRTTGTEPKAAAEKKTPTEKKTPTEKRTPTEKKTFERKSLAERKTVAAEKKPSRLSATKTPAARPQTSNRDKSPGKVLEKHAAASVSTSSSSHTSRTKTNGIGDTKPTPTKRLAPSQVTTRTTPKASTQRPTGSKAPSSARKSTEPAKRESDRFTRSAPSKAGDSRRSDSSKRPLSSKTSTSTSKAQAIPISGPSVYVDLTYIPHHASEDSVNMEFFRRIRSKNYVLSANDKGRNQPSVTVMDSLLEAKSKWEDPEAEVTVIPTYDTDALQEWEQKNVQQLSDSKITISQPASRSIVQMKDENFFMYKVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU87</accession>
    <name>A0A8B7ZU87_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 191-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108360.1">
        <property type="nucleotide sequence ID" value="XM_022252668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZU87"/>
    <dbReference type="GeneID" id="110988805"/>
    <dbReference type="KEGG" id="aplc:110988805"/>
    <dbReference type="OMA" id="ARREWDS"/>
    <dbReference type="OrthoDB" id="6256972at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052270">
        <property type="entry name" value="CACF_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028:SF5">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22028">
        <property type="entry name" value="SFI1 SPINDLE BODY DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
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        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108360.1"/>
        </source>
    </evidence>
    <sequence length="419" mass="48811" checksum="57280E9E6E60586E" modified="2022-01-19" version="1">MASRNADLYRWKRWSTKDTPGGSTNSNAKKKTQAPAADDIQEWIKKVEKASDRAAAMTFGPSNSSHGDSHFAPNRYGTAAATLEALHDHDEAYSEAQDLLSQWMAQKCGLDGEDDDLKYFVDDEDVSDYTASKQAAKSDLKDQWNNLLAENDPVAADPYNKMSSEELFHQIETRDDDQYVQSILGELMKKDVVESSFKRDLGIGAESKKKHDPRTTMAARQQKVKENREKRQQVREAQLRQQQQHKAAQSQARQMVMKEERSKALQRQREEALLQQEMARLRKEMQDQRRLEEDARQRKKDEEASKMKELRQEEARRRQEELQTRLNAESLIEEEKRKMEQKLENARAMKAAQDLKSLQQHFHAWYELVLTKQLALGKARALSDWRTLLRAWNAWRAYARASRAERETREIEESFKDLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUD6</accession>
    <name>A0A8B7ZUD6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein arginine N-methyltransferase 6</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Histone-arginine N-methyltransferase PRMT6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12 13 14" type="primary">LOC110989172</name>
    </gene>
    <organism evidence="10 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022109030.1">
        <property type="nucleotide sequence ID" value="XM_022253338.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109031.1">
        <property type="nucleotide sequence ID" value="XM_022253339.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109032.1">
        <property type="nucleotide sequence ID" value="XM_022253340.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109034.1">
        <property type="nucleotide sequence ID" value="XM_022253342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUD6"/>
    <dbReference type="GeneID" id="110989172"/>
    <dbReference type="KEGG" id="aplc:110989172"/>
    <dbReference type="OMA" id="HENMVRD"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF73">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="9">
        <location>
            <begin position="171"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022109030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022109031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022109032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022109034.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40320" checksum="02CFBFEC93399799" modified="2022-01-19" version="1">MESSSNAVELHQDVAGSGKTNEIKGSDKVFFSSYAHVNIHENMVRDEARTQGYRQAIMQCSDLIKGKVVVDIGCGTGILSCFCAKAGARKVYGIDASSIIEQAKQVVRENNLESVVELINGKAEVVDLPEKADILVSEWMGNFLFFEGMLNSVVVARDRFLKKGGLILPGKCTLFVSPVDCRKLYERRIDFWSSTKKTYDLSMECMIPFAKKCLLGSVRREDIPSESVIGPAQPLYDLDVNTVTLKGLDLVKGDFQVTCDRSTSLTGFATWFDAYFEAPGKDTKVLSTSPFSTRTHWNQAVLYRDEGIPVKKGDVIQGSMTLTPADLNERHLDIKLSYQIGDGQREEKMYNTWQTPGPVEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV92</accession>
    <name>A0A8B7ZV92_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Acid-sensing ion channel 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110989155</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109007.1">
        <property type="nucleotide sequence ID" value="XM_022253315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV92"/>
    <dbReference type="GeneID" id="110989155"/>
    <dbReference type="KEGG" id="aplc:110989155"/>
    <dbReference type="OMA" id="LERCHCV"/>
    <dbReference type="OrthoDB" id="8065060at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.820">
        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022109007.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="23447" checksum="4D568D33D9725DA1" modified="2022-01-19" version="1">MVRSLRAPYKSNCTESTLREFPFKYSVAACHFECLVHFVVEHCGCRDYRWPVKAPICSVEKQVTCVYHYEDEFVWDSGNCSCPMSCETTTYESKISQAQWPAKYFDRDLQEKYNLSHQYLRDNYVDVYIFMEEIMFMEIEQQEAYTLEHFEGDIGGYMGLLCGMSLITVVEWVDFIIITIYKRFIGSKWMCSRKVGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVC3</accession>
    <name>A0A8B7ZVC3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Netrin receptor UNC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC110989350</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the unc-5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109367.1">
        <property type="nucleotide sequence ID" value="XM_022253675.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109368.1">
        <property type="nucleotide sequence ID" value="XM_022253676.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109369.1">
        <property type="nucleotide sequence ID" value="XM_022253677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVC3"/>
    <dbReference type="GeneID" id="110989350"/>
    <dbReference type="KEGG" id="aplc:110989350"/>
    <dbReference type="OMA" id="ERYVIRE"/>
    <dbReference type="OrthoDB" id="5973910at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005042">
        <property type="term" value="F:netrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037936">
        <property type="entry name" value="UNC5A-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582:SF47">
        <property type="entry name" value="NETRIN RECEPTOR UNC-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12582">
        <property type="entry name" value="NETRIN RECEPTOR UNC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00218">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51145">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="1" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="3">
        <location>
            <begin position="88"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="ZU5" evidence="4">
        <location>
            <begin position="232"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022109367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022109368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022109369.1"/>
        </source>
    </evidence>
    <sequence length="662" mass="74951" checksum="3B048ABA6959C005" modified="2022-01-19" version="1">MADAREFEEVRGTHVPSNNTLRRSQSSVEQYSKAETERKRTSFSISDSALQANYGSVDQIFFPFSSHPGEENGPVIGEKTVYVRQQIPEVTLSEVARGVGPQWEELAKALEFNQDEITKIREDFSSSESPALELLMTWKQRCPRDQLTRLFDALLVIDKTDIARKALKRNSDLRRSSKFSKKTSKDVCGVDLNFNGNVPERSMLEKVVDEFKKRTRNMSDKERLEARCQLSDISIGYFGIQGGSLCLERYGVRLIIPPGAVVTDHPKMVYVSIRSTLAAVDKLRPGEIPLSPVIQCAPEGLKFAESVVLSFPHHAVSKRHSTMGIRMRNGDSSSGKWEDFDGNIAMTSDKHVVLLVSHFTEFTVVETLSPGSTKRLKVGAFGTKALPDDDRYTLLVYAWDNNPIANQEVMTEQKGSYQLDVFRPFEITYSKGDLNIRMSKIAKSWKMINEQVQSVNKETMWTFPFHSRTFHLKRRSGCLHVSSSKDLFCDVDIYQGRKQAGSLKVQLSLFPAGVLEQKKIQELVCPHCQSVRDSTPCSNFTAEFEAAFSRKVHGEDDIVGYIGCYGLPETRVMTLCEHLDAEKKWLQVAEHLTPKGYQFIKKAEDMTHPTKEMLKAFFEAKKLLGRGREDAIDDLRKIFEEIGFDRAVEIITEKSEQTSSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWH5</accession>
    <name>A0A8B7ZWH5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110989584 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109774.1">
        <property type="nucleotide sequence ID" value="XM_022254082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWH5"/>
    <dbReference type="GeneID" id="110989584"/>
    <dbReference type="KEGG" id="aplc:110989584"/>
    <dbReference type="OrthoDB" id="9904351at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039284">
        <property type="entry name" value="CCDC159/163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34533:SF3">
        <property type="entry name" value="BICD FAMILY-LIKE CARGO ADAPTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34533">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN CCDC163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109774.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="52226" checksum="7DC9A5A1EA81B637" modified="2022-01-19" version="1">MSRDWEHNLTSIVQETESNLARVRRSLNDSRYSHKSLPNSHPISSFSVKSSTLPRRYMTSSSYLTDYTGRSEWQPHSGYQSPFAHGSSFEGESAPSSLAESPALVAMLTEKIDNQAKTIQTLSRQVDALEKERDRSQTHLQRLDQELTLLNRRLQEGGVQLETERKVEGWKREVTLQLGDLQSQVVAQHRNASGGGYRGDEVLDSLTREVHDFKRHMQEDLALCRRDIESLNTRLMRQEIDIGNNQADGKDFSRRMDHMDRTLTSIADSQRSHSRELSHTLLGKQTSEQELLQLQSEMSRMMSTVERLENDMLTSSQRIAKEQSSTLKLNSPHRNNLSAVNSHGLSTSKAEVGQKKKKAASGRISKPSRKIPSQPFPRLPSDSEDLDASVSLSLASSESDDSSLDLLPHGANNIQRSAHTPFSRDDESSDAFSEMTSALVGHDPTLDLVDLASTSSISSIELDADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWI0</accession>
    <name>A0A8B7ZWI0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110989587</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110989587</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109779.1">
        <property type="nucleotide sequence ID" value="XM_022254087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWI0"/>
    <dbReference type="GeneID" id="110989587"/>
    <dbReference type="KEGG" id="aplc:110989587"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034579893" evidence="3">
        <location>
            <begin position="23"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109779.1"/>
        </source>
    </evidence>
    <sequence length="278" mass="30637" checksum="24FB3A51A25D1495" modified="2022-01-19" version="1">MRRVVHGLLLFSAALLLQNACGQGTTPAPKRPIPPPPPPPPPNMPPMFRNRTDPLTTAAPTRDPMDLINRGAIELKLDIEYSLFMTDNERDKFKGTMAATCNHYCATKGKCLIIPGTADADDVSVYKTRALSEMKRTAASFYIINPYDSTSLTMTSEQLMNMITTERKAIEADLGYRLDLDDLGVPTKPADPGPVLEWWAITLISVSGVLILAVVVATVYVLIKGKKSNKSDLMEMYDENRKESFKQMTDYANPQEGDVEANVDIDVTDGDMSDSDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWJ7</accession>
    <name>A0A8B7ZWJ7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hippocampus abundant transcript 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110989677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109928.1">
        <property type="nucleotide sequence ID" value="XM_022254236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWJ7"/>
    <dbReference type="GeneID" id="110989677"/>
    <dbReference type="KEGG" id="aplc:110989677"/>
    <dbReference type="OMA" id="LELMWYG"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17387">
        <property type="entry name" value="MFS_MFSD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF1">
        <property type="entry name" value="GH21943P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="29"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022109928.1"/>
        </source>
    </evidence>
    <sequence length="483" mass="52253" checksum="A4A89D4694D29CFC" modified="2022-01-19" version="1">MTKKRKKIRISKGKLVMKDNGATGIGEPSIYHALIVIFLEFFAWGLLTNPMLTVLDETFKEHTFLMNGLVQGVKGLLSFLSAPLLGALSDVWGRKSFLLLTVFFTCMPIPLMRVSAWWFFAMLSVSGMFAVTFSIIFAYVADITDESERSSAYGLVSATFAASLITSPALGTYLGSVYGDNFVVFLATAVALCDVLFILVAVPESLPEKVRPASWGAAISWEQADPFSSLRKVGQDFTVLMLCIAVFLSYLPEAGQYSCIFLYLRIVGHFSEQQVPAYIAVVGVLSVLDQTILLGFLIRTMGHKHTIMLALVCEMLELMWYGFASHQWMMWVAGIIASVCSINYPAISALVSRSSSADKQGVVQGMVTGIRGLCNGLGPCLFGVIFYFFGVNLDVKNNENPTPQTSPHSVIPGPPFVFGAFLVIVALLFAYFIQSSDSVGAGAAGPAHSSQLSPRSTEGSQPLLSDVETGHSGSVTLVDEANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWK6</accession>
    <name>A0A8B7ZWK6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc transporter 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110989225</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109145.1">
        <property type="nucleotide sequence ID" value="XM_022253453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWK6"/>
    <dbReference type="GeneID" id="110989225"/>
    <dbReference type="KEGG" id="aplc:110989225"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="177"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="12">
        <location>
            <begin position="461"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022109145.1"/>
        </source>
    </evidence>
    <sequence length="552" mass="60596" checksum="CF4C7C5088E5E280" modified="2022-01-19" version="1">MDESPDQLSLLAMDLPRHIEHSASKDDSAVVNGRTKSIYCKPALDQTNLLSHQRSFATSRSLQESTTMKRFWRKKRNPNYGTEQPASAIVTTGLATGRVSGDMDPFPPYLPSSNDVPTDVPAYYSQDSPARASNYSDRDDESLLNLSCRTDVDHCHAASSSSGPDTTSNRRAQRQLMFATVVCFLFMVGELVGGWISGSLAIMTDAAHLLSDFTSFLISLFALWIARRPPTAKMSFGYFRAEILGAVVSVLMIWVATGILVYLAVQRCITQKYDIQGTVMLITAGCGLGVNILLAVVLHFSGHSHSHGGLGHGHSHGGDSSDHDHDHDDNDTPSNNHVAMGMAEEPKDEDQLLNIESDPICVESEPLLAVDTNGTLPAVQTRHPKKHKRSQGNMNVRAAFIHVLGDLIQSVGVCIAAIIIIVKPDWKIADPICTFVFSVLVLVTTIFILRDAVQVLMEGVPRHINLHDLHADLKSLPHVRMAHSLHVWSLTTSQAAMAVHLCIDAGEDAEMVLQEASQLVRTKYHIGFSTIQVEHYQPEVMNNCGRCQEPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXM4</accession>
    <name>A0A8B7ZXM4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Macrophage mannose receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110988789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108306.1">
        <property type="nucleotide sequence ID" value="XM_022252614.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988789"/>
    <dbReference type="KEGG" id="aplc:110988789"/>
    <dbReference type="OMA" id="REFHWVD"/>
    <dbReference type="OrthoDB" id="6356110at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="CDD" id="cd21699">
        <property type="entry name" value="JMTM_APP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034258888" evidence="4">
        <location>
            <begin position="19"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1498"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="29"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="181"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="317"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="454"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="608"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="753"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="897"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="1200"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="1339"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1463"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1563"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1480"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1563"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1574"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1585"/>
            <end position="1596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022108306.1"/>
        </source>
    </evidence>
    <sequence length="1596" mass="177216" checksum="CD2E8518E10DF412" modified="2022-01-19" version="1">MLRLAVILLLFTVVQVQGTCDEGYFQFTGSSDCFSLKPNQGGQIRVTWMDARSECNNDGATLASIKSLNDQVYLNVFLNTASASEGVWIGLRASNDSGDYEWIDGNALGGFENWGTDQPNSSVSPGNRCVQILPDDKTPGLWKTVNCNEANTIYYFCQKDPVDNNSPVQPGCEANSDYFFYDGTCFMNISGSMSYDEARTACQQTSPNADLAAVNNVYHKNVVQLLMLSSNITSAWIGLRSDRGRFIWEDRTQNVKYTNWAAMQPQPSDTNACVSTDGDAWTCEDCNEMKPAICSIPIDTNTDTKFQGECPDGWGIVGYECFTYVSVNMAWENAQQHCEGLYPGASLYTAHSAQPINWQEYGVFPGSEFWLGMTRNDDNKFEIIDGSIVDYVNWKPGEPSSDPNKDCVIGAVPQTDAFTWSSADCSIGRRFFCSFLSISSPPDTGECQAGWLKVDNKCYRYFEDEMTFIEAQISCESKAIGGNLAAITYGGLQEILTYAMRGFARDVWIGLQDTFNSRDFKWTTGDALVYTNWAPGQPDGYLDFFDDSLDRNDCAKMIADSVSPGLWDDVSCSSTKLPYFCECYLDRLLLPSTPNPNLSCPPGYVEGFPGSCYRLIVKSQTYEESLIECQNDKASLASVADGYEQGVLQYFLSSSDNAGTTMWIGMDDMDKNGEYTWTDGSPVRYVNWLSANSPQPRMCVAAQKSAKWLESDCNETRPAMCRTTSDIPVTPPPGETHCDDGWVHYSNSNPRLCYLINTYRLPSGAVSSTQYVTYAEAKQLCETQGAILATVHSPDQNDWLYRNIRVTLGKRKIWLGMHRSIDGPLQWDNGDAVNYVFWANGEPSNGQEGTDCVTFFAGNDGVGPWSDSSCFERNAFVCQKVANDGPKPQCESGWEELAGSCFYFRIPQDGVLDWHNAEAFCNQQGSNLASLSSPTERESVSQILRNRYATNPESWPWIGFRRLPYDQDFIWSDGTPLNVGSTSWRNGQPDNIDDDCVVIESEGTATLWNDINCGLSRPFICKKPIDSGGLPTPGTTQDPRGACKGDESRIGSHCYKLVLEPQNWESARDECSKLGRNGDLASVPIYAVQALIASLVKYAPVDNIWLGMTSKMPASNFVREFHWVDGSSLTFTNWGSGQPSLSISQDSCVKMLTDPDEPGEWYDDKCDKVYSYICKYDLDPNAGPQPPVSFAPCPSSFVGTPPSCFRIEETERPFSTALDGCEAVGGILAPVMDGYENAFIELLMYNSGIKSLWVGLRADDSTSSKYEWTAEQWPIQYINWAYGEPSLVQGCVASVYSEGWKSVDCSSARPSLCRSKTDTPPTFPPVDPGLDCPEKWYAFNKKCYLVSTGFTGDNLVNAFFKCSTIKALPVSIHSWDENNFIRMNALNELTGRFVWLGLVLEQGRYSWMDGSLVDFTNWEDGEDPTLNDGKKCVVMVPESNGRWRRQDCSELAEVVCMLNEYEPSTPSAPTDGPKPPTKPNPTKVPVTKAPSGGLSTGAIVGISIGGAAVLVIFVIWLCYFCEKQKNNRKEWERRQRNDDIDEDYGVENVKYSHDIELRKKKVEKDVEKVETKSDGSSNKSDSISVASSNPSEDMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY26</accession>
    <name>A0A8B7ZY26_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription intermediary factor 1-alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110988859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108461.1">
        <property type="nucleotide sequence ID" value="XM_022252769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY26"/>
    <dbReference type="GeneID" id="110988859"/>
    <dbReference type="KEGG" id="aplc:110988859"/>
    <dbReference type="OMA" id="ASMITHE"/>
    <dbReference type="OrthoDB" id="10250935at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="7">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022108461.1"/>
        </source>
    </evidence>
    <sequence length="664" mass="74437" checksum="725A0F23F18F4EBE" modified="2022-01-19" version="1">MASNVTVQSVLGKISQVHLECSICSCRFKEPKLLDCLHSFCLKCLQELRHHHDPDSTKLTCPLCRRDTQLKGNGVAALPNHFTLGALVEEFTMQEQLLEGQGLEIKCQNCEEGNKAISRCSDCDSFFCLECNKAHRRMAMLRAHEVNTLAQLQSGEISFKSKLRKQVPKCGKHPDQNVNIYCNTCEKLECTTCSLLDHAKHSLTGQMEAFDECKREIHALMAKAEQKTAEFKVATQATGKMQKTLYGMLASVNKKIDQKVDEGRDRLEQEGKTLKQEAERFYKGRVKKLEAAHSSNRTEVSHTEQKLDEMKQLMDQASCHEILDLKHKLLHNLKELTEKTPHEVPRGLTFINFESKDLLFTIGRLVQVPADENDPKPELKVQTVDPSSQVPSCLPNKCQKKAEIHKFGKYGTKFESASHVAVFSNNEGVIVDRSCNRLISFIPKSPQSPAVSKEIEIYGLYNPRCVVVTKDDKLIVVAGQIIKTFDRAYCPLIHFKSGKKAKNYPTCLAVNDNNQIAVGFSKEEEIFLHNLDGTLITRFSAPGIGDYLTSYKQRLIYTDSDMHKLTSVNYNGREVFSIGVNATGHERGKSTLEGVCCDEDGNIYVAMELVDESDEIHQFSPDGQYIGCVIKGFDHVRGIAHAPNGDLVVAEETSVVVCRHVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0A4</accession>
    <name>A0A8B8A0A4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">40S ribosomal protein S9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110990213</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110787.1">
        <property type="nucleotide sequence ID" value="XM_022255095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0A4"/>
    <dbReference type="GeneID" id="110990213"/>
    <dbReference type="KEGG" id="aplc:110990213"/>
    <dbReference type="CTD" id="6203"/>
    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10 15" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="12">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022110787.1"/>
        </source>
    </evidence>
    <sequence length="191" mass="22360" checksum="BF62D449B4CAB313" modified="2022-01-19" version="1">MPRQVCSKTSVTPRRPFEKERLDQELKLIGEYGLRNKREVWRVKYTLAKIRKAARDLLTREDKDPKRLFEGNALLRRLVRIGVLDESKMKLDYVLGLRVEDFLERRLQTQVFKSGLAKSIHHARVLIRQRHIRVRKQVVNIPSFIVRLDSQKHIDFSLRSPLGGGRPGRVKRRNMRRAQGGADADGEEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0M5</accession>
    <name>A0A8B8A0M5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110990562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022111308.1">
        <property type="nucleotide sequence ID" value="XM_022255616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0M5"/>
    <dbReference type="GeneID" id="110990562"/>
    <dbReference type="KEGG" id="aplc:110990562"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000013">
        <property type="entry name" value="Carboxy-terminal domain RNA polymerase II polypeptide A small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040078">
        <property type="entry name" value="RNA_Pol_CTD_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01124">
        <property type="entry name" value="C0.1:_RNA_Pol_CTD_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="7">
        <location>
            <begin position="92"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="4">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR640078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022111308.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="30540" checksum="1295CDF0B954CDB5" modified="2022-01-19" version="1">MDSTSIITQVNRDEEPLNTFPTADSAPTTARKPRSRSLLSSFFCCFGSTGRTPPTTVPPPEENGQKLHEPASSYAPSCPTTHKYLLPPLRPSDAHKNCIVIDLDETLVHSSFKPISNADFIVPVEIDGTVHQVYVLKRPHVDEFLKRMGELYECVLFTASLAKYADPVADLLDKSSVFRSRLFRESCVFHRGNYIKDLSRLGRKLERIIIIDNSPASYIFHQDNAIPVSSWFDDMSDKELLDVLPLLDRLAKEDDVYKILRKENHNHIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1S4</accession>
    <name>A0A8B8A1S4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 31-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111634.1">
        <property type="nucleotide sequence ID" value="XM_022255942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1S4"/>
    <dbReference type="GeneID" id="110990856"/>
    <dbReference type="KEGG" id="aplc:110990856"/>
    <dbReference type="OMA" id="CVTEEDM"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042419">
        <property type="entry name" value="LRC31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24109">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24109:SF3">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111634.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="46853" checksum="76FB248BCB68576B" modified="2022-01-19" version="1">MYLKELKPLQRLNLMDCLLNGKDMVHVAESLKNLLNLVSLDVSCNNLGGTAASLVMRLKELKPLQRLNLRNCSLNGQDMVHVAESLRDLPNLASLDVSCNNFGGTAASLGIHLKELKPVQRLNLMGCSLNGKDMVHVAESLKDLPNLVSLDVPGNNLGGTAASWGMHLKDLKPLQELDLGDCSLNGKDMVHVAESLKDLPNLVSLHVSCNNLGGTAASWGMRLKELKPLQELNLFNCSLNGQDMAHVAESVKNLFNLVSLIVSYNYLGGTAASWGMYLKELKPLQRLKLVRCSLNGQDMVHVAEALRDLPNLARLDVSGNNLGGTAASWGMFLKELKPLQELDLSSCSLNGQDMVHVAKSLKELPNLVSQIVSGNTDLAGTATSWCLYLKHAKALRKLDLRYCWPTEEDKKHIHDVLSNLDELLLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A555</accession>
    <name>A0A8B8A555_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Clathrin heavy chain linker domain-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110990392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111071.1">
        <property type="nucleotide sequence ID" value="XM_022255379.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111072.1">
        <property type="nucleotide sequence ID" value="XM_022255380.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111073.1">
        <property type="nucleotide sequence ID" value="XM_022255381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A555"/>
    <dbReference type="GeneID" id="110990392"/>
    <dbReference type="KEGG" id="aplc:110990392"/>
    <dbReference type="CTD" id="130162"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012331">
        <property type="entry name" value="Clathrin_H-chain_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032755">
        <property type="entry name" value="TSNAXIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF11">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN LINKER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15739">
        <property type="entry name" value="TSNAXIP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translin-associated factor X-interacting protein 1 N-terminal" evidence="2">
        <location>
            <begin position="51"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022111072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022111073.1"/>
        </source>
    </evidence>
    <sequence length="599" mass="67259" checksum="B2C09C50BD576540" modified="2022-01-19" version="1">MQHSTEEKILTARPVLPPIKPEILDQHTQQRLKNGLECNAVEEMVNPDYFSEKCLEESRYSLIKETLNQLAEYLPGYCPLLMAVKAEFENCIQTIQRGNQEALYLSGKIRSMVAEQTTLSYYTRRIDQLKQIIPVIQSNNKKLHPEQMTIQMESGDHLQEIQEQVISVEVPVDNGHVNAPKRLFHGLILGESIDVEHLRKQSSSLDQQVNNLRQARKSHYTPREQKDRLKVQLATKTKAKDLVTEKNFQLKARCRKLRVALDALRVYEKDALVQPTQAEVIIHALTRSNSKMSSRSTDVLSSTFDDDDPSKEREAEMLLDYIEYFNELFGEGNYKDAAMHAASSPKGILRNSETLSRFKGISARSGKTSPLLIYCEALVSSVPAVGLLPNAETSLECVKSALVEDRLDLVMYWLAQKRLTCSEPLGHLLYNYTQGKSEDILSKGLPLAEAVYTEVDAQIQAAVCMCKQGKVQAMADYAISAGFGKDMYVGVLVACPSLALAEVLIQLRDTKGKPALSVGAVVFALLQTDSYTVGLQLLDEIHQRIKSVHFYHSQYRYGFGAMPANKRRHQESHLLVPGTSPYTAGIDMDFTTLPAQTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XFA7</accession>
    <name>A0A8B7XFA7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079433.1">
        <property type="nucleotide sequence ID" value="XM_022223741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XFA7"/>
    <dbReference type="GeneID" id="110973159"/>
    <dbReference type="KEGG" id="aplc:110973159"/>
    <dbReference type="OMA" id="AWICRHV"/>
    <dbReference type="OrthoDB" id="10159327at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022079433.1"/>
        </source>
    </evidence>
    <sequence length="848" mass="96317" checksum="87BF7E57BDDD7BEA" modified="2022-01-19" version="1">MDNTPSTFSYCQRLTFQAWICRHVPLARSRVSHTRVQVLSSTNFVPPRPEFNCSSPQKLLETWTKRLRSNQNPERPRENEKRSKDTTAVFSAKAKDQQANTHNTGGLAAITDASQSDHSGRVVHPNTATDKVDVSAGHSRSSYRVQDKNSSAEKEDLPVGCLCIPILPLHRLRRKRRAKVAPFNLPSPFVKTTSKSATSGEDRLVQPQMAEVSVFGVEDRDDQDSPCLGLPSHRMMKEDLDEWCQRSRSEAHFEREGDEVKGISRESISLPPRPKTSRGIRQDNGRNDQPFKGSEKSREEISRLDELEQDEEAVLMGGEPEIMVSRTIMENGNSDISDSEEVLYCWKNVEAKNSEDGRGMKGEEVVVCVLGEGATSNNTRREYLPTLSPEDLPPRPKTARGFRRECGRGDLRSVSGGVGVRTVSEVIRTLTREEDREEEDEYVISGADLKSKKSSSSLNSGEALSIWRNPDVFYNEDEVEDQAGLSSKGYEYDTRPKIDKAIPSGQKGVSPSANDRNKGTITPKYSKESVDSDGVIMTPEDELEYDRQQREQWQLAGIGEWSVLCQDYDEDDYESECYLRMDELQKEQAIMEDWRAITERYQSIGVIQDLQNMQTLCKCTINQSERALRQFARICRGPVPLSKSGQTKAEAIASLSKKAQKQTRRISERISDTFMEFYQIFEELDILRERQDRVEESLQGDLEKRDASSADLSWSSSQSSVVTPRLISSRIQQRELDMDLVDKYMEDYRVKSTSLFNVMPTIYEDEIFEVEECREEESEGDFPEYSGMDNVCFDGDDVRVNDTAKNNREDSSMMNRVADEQNNEDVVEKQEEGEGGVVGLNEEMRKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XG79</accession>
    <name>A0A8B7XG79_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110973357 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079789.1">
        <property type="nucleotide sequence ID" value="XM_022224097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XG79"/>
    <dbReference type="GeneID" id="110973357"/>
    <dbReference type="KEGG" id="aplc:110973357"/>
    <dbReference type="OMA" id="IVKSHYM"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="36"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079789.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29711" checksum="8CB8BAACDF3968B9" modified="2022-01-19" version="1">MNFSASDDYHGESRIVQHSVFMQHIDKVTFQPGDEVLDVGCGSGEETKTIATKVRSVTGVDSSEAMIATAQNSNSASNIRYVVWDARTVGDNPEWRDRFDKVVSFFVIHWIPSAEQPKALEGIVACLKTGGEGLILIDTDVDNHHLLRQSYAHVKNHPKWGVFVKDYVSPVNLWSRPIPDTVELLKTYGCTSVHCEIARQDISMSELQFKLAAKTLLGYLSLIPSEDQETFLEDLYRWALSDFADEARPGHVLHADQSVVIHVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XG95</accession>
    <name>A0A8B7XG95_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9">Neurobeachin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110973084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079256.1">
        <property type="nucleotide sequence ID" value="XM_022223564.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079257.1">
        <property type="nucleotide sequence ID" value="XM_022223565.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973084"/>
    <dbReference type="KEGG" id="aplc:110973084"/>
    <dbReference type="OMA" id="IVFKVME"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF112">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1953"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2064"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2509"/>
            <end position="2542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1372"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1419"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1431"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1449"/>
            <end position="1471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022079256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022079257.1"/>
        </source>
    </evidence>
    <sequence length="2741" mass="306656" checksum="99716158782C4C0E" modified="2022-01-19" version="1">MSSTEPSPDPDHAQDQGQDPGPESGNEQLYQLWMLYTSNSDVQFFQKYLERFIENYNREIDLEFRHLEEGQPLEGPGMSKLPGTILQVITKQLAGCAQHCTESGSALQDSVQLALQMLQALTIICRHHDNLALVASCEYLKYIVPMTTSIINKMSSVDDGDRSLLVSYISQVLHLFECMYDPYHIWRKQQRNLQVNLSLLKYKPSILSVELVPFFYDCLQENTWRLLQSIDVHVRVIHMFGAVLAGSQENAQVAISPATVDVLFALLDTPVPSSDFSVAPAGNLQLVQELALRCIVLMVLATHGCPPEQRQVELSEIIQQVLQKLSSDNVPQQLQLAIFRSIPQVLHGRRKLALQEAFVSVDVFGILISIIEKAILSGSRRQLTGFFCLHIMAVVMADCPLAKTSFRETIGYHRLGQLIISLGQPSQQLIGALLDMMVDTTFKAEVKHVLHNTGATHILMRLLPLIKSEELQISLSHSLASCCSQSDYNRMQCCNDGILSTVLDALEARESLHRKTQERLIVLTEALGSYSISSTQLKRLIGLMRGTDDQSLSPQCLRLMHALSVMARKEGKKGAHHYFDLQENLSGISIPVIRKWPGHGFTFHTWLCLNNTPVTTAAIERGGFYRRQLYSFFTGNGAGFEAFFTHDGVLVVAVCTKKEYYTVSLTDYPISDSQWHCVDVTHMSSRRPFSQSQLCIYVDGHQRLVSQLKFPIISEPFISCRIGYPIALSSLQQQLAEDSSSSSASGHSASFSFHPSRLHLPFKLLSGSRGSGASGGGGGEAESPVGMVPVGMQDMEWGEPRSLQGQLGSVCVFHDVLQAQQIKKLYALGANNMTLFQSDDSDISDLSSKLLLYYHGKACRDPVCLDLAPAHLYNGRLKGHSCDTWDVKDVLNCIGGVQVLFPLLELVTQENETGKPAFLTHANDDAVDSREPVNKQMSSDDEWEVIPHDQIDLRNEQNHVAGFVALLKNMCVGHPINQDMLHKSQGIATIGALLQKVDSLLIDVNVLMAIKHLVEAVCFGHQSLLKHAYRYILFDFRIWSKSVFEIRIGHLQYISTMIKDDKKRFRRNFGVQFLLDTIRTYYSPSTTDLSAEDSRIIRNSLLGLIRFYVSKQINHKELSAIINFVTAVEDEILIGEVIDMLITFLESSSKDQLYLLLFEEGKGDLLYALLTKKDYTDTLRVRVFKMFSLMLRSNKVYEKSKHRMRLMDVGFSGLTLLMGEMPVTMPIAKNMVEMITEGHINYAGLLAVLQLLHRASSLIKLEACTQLLHILYTEKESKVKLAKVPGWQDTLARLFVRDAAAGPDIGLDLNGLALTPSSIPTTPTTPQRVLPTDNADNGKLPGCVVMAATSFVLPDAGDSQATDASDLLADDSSVADSEDITSSQSVPRLVVETDTPDSLSYSESLSVVSSDANFGQFVDTMATGDGGQEQGADSDSSFTIGSWPGGDYDSQTSPLHASRSSLNSATPTATLRPSHLILPTAGGAPGGEEEEGPEGSGACERTQETLADTLTEVVVQLMWRGVPGSDEEAWAARGQIFVSLSKLAEKYELLRPANQIKRHLLEKLLEVSANDIKNAGSSDHLTHAENALWLMKLVQDFLFGEDQEDSHAWSDKLAEAVIDVIDALCVWEDTTAADEWAEMSQLGLRIMLGFAAHDDIEVCATAAARLHHLLQTRPIPSPSEACFLLGSLDSALMRSLDARERETYAYLIPLTRAMIELYHKQLGMPNFLPHLPTTDTSPTFFEDFQSYCRSEEWRSYIEKQVKPFMQEYLTLNFSSISAKMGKLWRKCFDLMNTDIHRRERERGESKLRFQAKISEPFSTLCKTETTRHASILNKLQNQHQSTLRQWRASKRFLTGERGAWAERTDEHIYWKLSAQENFSRMHLKLTQNFMFDQHIDASQMRDNTGPVAEATDTLSLEIVKEARVSDMELQDDRLGDEEWNIISESTETEQGGAVKEKTVVSEECNLITLVDVIPGKLEVTTTHVYFYDNSPDKEENAGQDFKWSLSHLREVHLRRYNLRRSAIEIFFISQTNYFINFKDKKTRNKAYSRILSLKPPNLYYTGAKSPADLLKSSTLTTKWVNREISNFDYLMQLNTIAGRTYNDLSQYPVFPWILCDYTCETLDLQDPKVYRDLTKPIGVVNPKNIEEVQSKFENFEDPTGTIDKFHYGTHYSNAAGVMHYLVRVEPFTSLHIQLQSGKFDCADRQFHSIPSLWDTLMENPNDVKELIPEFFYMPEFLENRNNFDLGYLQTGERVNDVILPNWASSPEDFINKHRQALESEHVSANLHHWIDLIFGYKQKGPAAIEALNVFYYCTYEGAVDLDAIKDPLEREAVEGMINNFGQTPCQLLKEPHPKRMSVEELSRKASKNQTQLLNVFDHLSELKAFFVEVSTSDSDPLVYVHVPRSQPKSFIYQGMPDAMVTVTEKGTLGSHGWLPYDKSISNYFTFDRDSSLINAKIRKTVSGPFAPGLKVTPSLFVTTHDAKLLLTGGHWDNSLRVFSVAKGKPLAHVVHHTDIITCLALDNCGMQLMTGSRDTTCMIWEIAYQGGVACGVGSQPVQTLCGHDDEVCCVAISTELDMAVSASKDSTVIIHTIMKGHYVRTLRPPALDPQAPLTIPLLALSDEGQVAAVCMPQYGKKASQELCSLHIYSINGKHLCDTTLSSKITHINITGEFLLTADEKGTVTIRRLFGLDICTTMPLFVPIHCVSVVPTKSQILVGLRDGKLIIVAVDRPAEARKLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHX0</accession>
    <name>A0A8B7XHX0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973696</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080394.1">
        <property type="nucleotide sequence ID" value="XM_022224702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHX0"/>
    <dbReference type="GeneID" id="110973696"/>
    <dbReference type="KEGG" id="aplc:110973696"/>
    <dbReference type="OMA" id="FFNGTEE"/>
    <dbReference type="OrthoDB" id="10070532at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034493967" evidence="1">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080394.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28024" checksum="91F10DEEBD0489BB" modified="2022-01-19" version="1">MHTFVAVGFILVTLAAAKVQVPPDVAGFYGDLREQEPKPCCAPSYFTFKSTHFLTYSLGEAGLIVEMQQATGAYDRIAEKIASRIHLGFFNGTEESYHTIDDYHSGVSYSITRIGGELICRSNELEGEFPEDCIPDDATYVGSSSLGDRAVEVDSWYMSKTHPGQDVHRVRTVQKEECVPIYSTGRYVSPDTGATFQTESSHVTDFHLGICDEDKLFHVPAICFERATDNSKTPKRLRKIVRLSPTMSYIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJ24</accession>
    <name>A0A8B7XJ24_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Erythroid differentiation-related factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080799.1">
        <property type="nucleotide sequence ID" value="XM_022225107.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973897"/>
    <dbReference type="KEGG" id="aplc:110973897"/>
    <dbReference type="OMA" id="AMHCYEA"/>
    <dbReference type="OrthoDB" id="419432at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056582">
        <property type="entry name" value="EDRF1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056583">
        <property type="entry name" value="EDRF1_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15000:SF1">
        <property type="entry name" value="ERYTHROID DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23788">
        <property type="entry name" value="EDRF1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23723">
        <property type="entry name" value="TPR_EDRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EDRF1 N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="EDRF1 N-terminal" evidence="3">
        <location>
            <begin position="229"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="EDRF1 TPR repeats region" evidence="2">
        <location>
            <begin position="951"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080799.1"/>
        </source>
    </evidence>
    <sequence length="1449" mass="161793" checksum="912F55AFB2AF2C29" modified="2022-01-19" version="1">MMASSERNLEEDRDEAWEQPQSQVVDVKSTAMVKLARRLPVYQFSRLDQNTDLHLPPDNWLRSEAQLSKTWVTGECTQFSSFAMAETLPDTVGEVDVISAAENIKKLLKIPFNKMQVSMAVHRVGKTLLLDELDLLKHLRSASQGEREWMKTFLLQAVLSEGKNLTMTRKTNELLQSWNLLSKFLCYSIGNSPDESVPQQSYDFEEQHLPQSQSALVQIPDLLPKTKPSEFARQVLWQFEDIRMLIGTDLPIFGEGTHPAVSLRLKDMSSPINVLTGLDYWLDNLMSNVPELAMCYHLNGIVQKYELLKTEEIPNLEEAKFAPQVVKDIAQNILSFLKSHCTKEGHTYWLFKGQDEDVVKLYDLTSLCNEYPNRPWENPFISPVAMLLYRVARNLSMSGPNKKDKSTMYKLLKNCLQLLEGNEGQHPEVAASASHLLSHIFINEDDLNDPQPPAASAPASQKASNKAQRQPADSSSASDEDELVIEEEDERGSSLSVPSMNTQSLKQPSSKHSSSSGMGGFKECGRHRRRSAKTVYASREEKARMALAFIVKGLKSIMKCPQSTDTRGGQKQAAKLPSPLPSPTRVRPLCYSRPSVTRDTGGKAELADTELRQLPGGTVSALDDFGGVDSGAETEQLSKEQEDLFLPEKMMSDTNRDTLGGVVVEAHSTEARNSSEARSTTKLLEQEVTTSSTHVVPVFTSPGMTDKSGQVVEIEGNAKPEEPVISSRSKGSILPGQLPGAVLQEQPNGKDGSSGSSDRSAHFLEDSKPLGAEEPLRLTDLSIAGGKWHPGSWQHELSFLLLKKAGETYLVLAKANRDAERYGLALHFAHMSLFCQSACQSMDDRSSVNLPDPSSALNLLSDQLAVCGDCLTLLTHNLVSYVRQREDFRYSTAEDRLILSEAQQHHLTNDHEWAVDFRNDTEHNLKTSIQCYTLALSEGTGRGDDYLTALRRKQGNAHNELGVCYMNQALAMRNEEGTFQEEQDLWYKSLRCFESGIKIFESVKDTANISLLLCNVGKLMRLCAFSCGESELYKRSEMRQQERYYYNKAVDYYQRALTRLGQRKKNPSLWESVTWELSSTYFAMATILQDHPPLSSMAQEQIEKEILELMNKALQLCEVDDITPAKQPVYQYRTATIHHRLASLHHNAYRNQSSQQKQKHTRSLAELHYQKAIRLFSDLDRPSELLRVLLERVALLEHQFEGQSGVSARIKTLQSALEALLQCRDALNALQKAWGKEARELGMPTSTVQDAGRVDSDVVERGRMSPKAQVDVGEWSRSSDDETADPKGTLSETDVPNSGTRNLGVDPLERQRRTSEEEAVEDPGMHQPAPGSSETGASSAGGQGSQPEGQGSKVKDRLSKEEEEERQRLESIWESRLQYMLRNLVKLHSTNKKGMQQATAYKKMYAASLGRTLPASLSSVPPSPASSTESPVTLLSILDEVQQLFQAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKE8</accession>
    <name>A0A8B7XKE8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gamma-soluble NSF attachment protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-ethylmaleimide-sensitive factor attachment protein gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110973716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080430.1">
        <property type="nucleotide sequence ID" value="XM_022224738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKE8"/>
    <dbReference type="GeneID" id="110973716"/>
    <dbReference type="KEGG" id="aplc:110973716"/>
    <dbReference type="CTD" id="8774"/>
    <dbReference type="OMA" id="RSWFHAA"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF2">
        <property type="entry name" value="GAMMA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022080430.1"/>
        </source>
    </evidence>
    <sequence length="321" mass="35405" checksum="23D4121B63B02E05" modified="2022-01-19" version="1">MAAAVSAKKTVDAEGHAREAEKCLKTSWTKWKPDFDGAAHAYEKAGLCYRHAKSLEKSKAMYMKAAECHTQCKALFHAAKAYEQAALLLKDMKEYDEAVHLITRAASMFREHGTGDTAAISLEKAAKMMETINAKSAVDLYLSAAEIAENEDRIRQSVDSVSKAARLSVRTRDFDKALQLLEKARNMYDVVENLGYVYKMVVVTVLVHLHRGDFVAASKVCNAAMRYDGYAMDESSSLLEQLLEAYDQQDQESASKILFLPYFTYLDNDYVKLARTLRVPGGEVGGGGGRQELTTEGATAMGGQDEAVEDDEEDEYAGGLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKU2</accession>
    <name>A0A8B7XKU2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC110974236</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110974236</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081422.1">
        <property type="nucleotide sequence ID" value="XM_022225730.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081423.1">
        <property type="nucleotide sequence ID" value="XM_022225731.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974236"/>
    <dbReference type="KEGG" id="aplc:110974236"/>
    <dbReference type="OMA" id="EGHEWYL"/>
    <dbReference type="OrthoDB" id="10066200at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="890"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1247"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="845"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1080"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1247"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1271"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022081422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022081423.1"/>
        </source>
    </evidence>
    <sequence length="1288" mass="142537" checksum="F1DBC8439014A7C0" modified="2022-01-19" version="1">MSNALRLTRALPLNDAGGTQLFTFLLSMNDLESFFDKPTKSSPIYYEGHEWYLTCGGYQSKESDDIYLGMYLYWDNKAAGEGVSCRADYRLIVRNVRDASESVVSEGSQVEFSAPDTLGWGKRELAPLHEVLAPGNGFLVDPGRTVIVELAVRYCRTIYQQLVDFSQLPEHMNQPFSSYFTPNFSLCGFDFYMSFYPLGDREEAERHVSMYLHRFNNPHIPECLCCRIRYRFFLGDLVSPTGDSKTFEFSFRSDRGYGRFKAFEPLANMDMFRKGLVPLGVEILSIIPFAFVEVPLATRGYYHTDNFVFDDVIFPDHRMNVWKLSANNSSKYLSLRLDTEDRNKIFPVGSRGTGRDALCTKYLQWKAYLLSRTDRSYNVSISEVPISAYFSPAFPEKLFSMATKVPIQRAKALDGDYCTTEEPSLLFRIEFFNVQDIPGVLQDYPVLEFERFRLYQTREGLRRCLDVNSSLRNQLDELRKRLNEVMNISESNIGGSSKQQLIREFRSLLQASDETDSSSQAAYKSMISTPGSDTFATAFSFSGTPSLETPAAGRVSPYVTSGTRREPLNKVSQLFGSHPGNDLPDFGSAPPATTAVAMPSATKGKVASLGAALRTSKGGSSSFFRGTQARASTASTSSVRFSKSNSKPTLGSSASQSALKEGQHKQSSGVAPAQKSMSSLDRQQVVSKHFFISGGNAPATQPTGPGAVKTMPEQTIYASLSVPSKTVPTITSPASNTFAIVSKPAAKYDSEPGEEYETSTEGRKQKFNPNIFKAVLPKWGSSGASDQSSGKATTLPRSVHPGERVTDFYGNKSLERPAPGIFNQPSRSTSNLSATRHPTPAVQKVNPTPSPNSTLTRSGGVTSLNNPGNYSNPPTTISTAIVMPVQDVTYTEPNRIRKPPVPAPRKGLLKNPSDDGKGDDNYFDGSQATDVYTKETSQYPEKSKLDYALSANQTPSEEKAGFSRASVASIEDPMLQTEVYSIFAQAARDGVKLVEEPPEMHEPLVTAAPEPSAKPQGGPELTTKSTSRTVPAITVTDPACASSVVPRHGAVGGQPLSPSILKKGDSFSSSQGPTVRKSRSANNVRFSEDNVSVTSQSSSVEMPGQAQPGTNQGDLQLPTPNKPTPSFDQYDGHNGQYPNGGQSARQMGQQQQKYSQQQNYEQKFQEQQYRTQLQKQQVQLQQQQRQRQKQQLPEQQYQRQGQEYNQPHRLTESKRTQQVPVAAEEKQQYRLEQLRREHQEYVNQLLQQQQQPSISQQQHLLQHRSGPRSEANLSRTKSASSEVVQTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLC2</accession>
    <name>A0A8B7XLC2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Delta(14)-sterol reductase</fullName>
            <ecNumber evidence="5">1.3.1.70</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">3-beta-hydroxysterol Delta (14)-reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC110974347</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>4,4-dimethyl-8,14-cholestadien-3beta-ol + NADPH + H(+) = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46812"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78904"/>
            <dbReference type="ChEBI" id="CHEBI:87044"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5alpha-cholest-8,14-dien-3beta-ol + NADPH + H(+) = 5alpha-cholest-8-en-3beta-ol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46456"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:86131"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Steroid biosynthesis; cholesterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.70" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022081613.1">
        <property type="nucleotide sequence ID" value="XM_022225921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLC2"/>
    <dbReference type="GeneID" id="110974347"/>
    <dbReference type="KEGG" id="aplc:110974347"/>
    <dbReference type="OMA" id="PNYMGDL"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="UniPathway" id="UPA00063"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000001">
        <property type="entry name" value="delta(14)-sterol reductase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="7" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="8 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022081613.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51006" checksum="B75343ACBC3E0151" modified="2022-01-19" version="1">MQTNGTSLLNSTDKRRRPTAENHGSMAQTNAKVPRTAHYEFGGPIGALFIMISLPLFIYYLYFACDKNSCAVTFQPPLPSSWDDVFDLDVFLIFLGWIAFQAVLYMLPIGKKVKGLPLRTGRRLQYRMNGLLAFVISMVLFAALVYFRYPVTILYDKFLPFITSSLIFSAILSVFVYIKSLAAPNHALAEGGNSGNVIYDFFIGHELNPRLGNFDIKIFCELRPGLIGWVLIDLAFVVKAWTDFPDNPPWCLLAVTFSQVLYVADSLWFEECILSTMDIIHDGFGFMLAFGDLAWVPFTYTLQARYLVDHPEKTMPSYCVLTVVALGFLGYYIFRASNSQKNAFRQNPNGDSVKHLQTIPTATGKRLLVSGWWGFVQHPNYLGDLILALSWSLYCGFDSIIPYFYPIYFTVLLVHRSLRDSAMCKEKYGTAWDRYCQKVPSRIFPYIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLF1</accession>
    <name>A0A8B7XLF1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110974368 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110974368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081643.1">
        <property type="nucleotide sequence ID" value="XM_022225951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLF1"/>
    <dbReference type="GeneID" id="110974368"/>
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    <dbReference type="OrthoDB" id="10476334at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022081643.1"/>
        </source>
    </evidence>
    <sequence length="302" mass="34355" checksum="5C57B3C1210075CA" modified="2022-01-19" version="1">MSMFASGSLNNTPFECKTLQHYLINSTFKRVPSNSTSMEGDIPAMMDSIHQRDDEGLQQAGISSKLVPSVKSDIRSNLEIYNKDRYQTSLDSCSRDICGHTTCKDTCLYQTYRSSERLEVDRDSTSCQERELHQGHSPLTGIQEECQWNDLLMNSPADTQRDLNPQHTEEEDALLGIDYSLRQSVEAEIEAFRINLHNFISDHHQQYRQVLLHGIDPITTQNSVCDHTVIGRTNYEWSQTNSSAQCHIEESSGSSFRIQDDGTCQLYQPNSSQEDDINYALLQLLTSANAVSHTLRRQEYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN91</accession>
    <name>A0A8B7XN91_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Potassium voltage-gated channel protein Shal-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110974295</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022081526.1">
        <property type="nucleotide sequence ID" value="XM_022225834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN91"/>
    <dbReference type="GeneID" id="110974295"/>
    <dbReference type="KEGG" id="aplc:110974295"/>
    <dbReference type="OrthoDB" id="433309at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005250">
        <property type="term" value="F:A-type (transient outward) potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000028">
        <property type="entry name" value="potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000016">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000004">
        <property type="entry name" value="Potassium voltage-gated channel subfamily D member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003975">
        <property type="entry name" value="K_chnl_volt-dep_Kv4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024587">
        <property type="entry name" value="K_chnl_volt-dep_Kv4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021645">
        <property type="entry name" value="Shal-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF105">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11879">
        <property type="entry name" value="DUF3399"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11601">
        <property type="entry name" value="Shal-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01497">
        <property type="entry name" value="SHALCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="14">
        <location>
            <begin position="38"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022081526.1"/>
        </source>
    </evidence>
    <sequence length="647" mass="72409" checksum="F5038324D2BF0904" modified="2022-01-19" version="1">MAAAWLPFARAAAIGWVPIAPNAMPVAPERHTTANEGGRIVLNISGRRFETWRHMLEKYPDTLLGSNEKEFFYDEDSGEYFFDRDPDLFRHILAFYRTGRMHLPREECINSFDEELAFFGVMPEIIGDCCYEDYRDRKRENAERLMDERSSEMGDAPDLHTLREKMWRAFENPHTGTGALVFYYVTGFFIAVSVLANVVETIPCSPFPGTVEDVPCGERYHDAFFCLDTACVLIFTVEYILRAYAAPDRCKFMRSVMCVIDVVAIMPYYVGLMFNSDSLSGMFTTLRVFRVVRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATIMYYAERSVENTDFFSIPAAFWYTIVTMTTLGYGDIVPHTEIGKIVGGLCALSGVLVIALPVPVIVSNFSRIYHQSQRADKRKAQRKARLARIRLAKNASGNAFVSRKKEADRLAESGCSLEDLTSKYSAYESQHHHLLSCLEKTTTWYDGLSEAEPMVRTDQSADFTQRQYMETEYTYNGVPFTRSLGTGSPPMTPSHSHESANPGRNHAGSSSCCTRWARGNRYQATPTSPDDSDLNDIHVHDPNANPGIVIPTAKEDLSLDAYPKMNCATTTVTEAIVTVTPPSMAGDGDSLNTTVSTRSSPAVVRVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNS2</accession>
    <name>A0A8B7XNS2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ileal sodium/bile acid cotransporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110974862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082464.1">
        <property type="nucleotide sequence ID" value="XM_022226772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNS2"/>
    <dbReference type="GeneID" id="110974862"/>
    <dbReference type="KEGG" id="aplc:110974862"/>
    <dbReference type="OMA" id="AHYVIMP"/>
    <dbReference type="OrthoDB" id="203097at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008508">
        <property type="term" value="F:bile acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000035">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF28">
        <property type="entry name" value="P3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022082464.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="36640" checksum="9E36993A49BDF10C" modified="2022-01-19" version="1">MTDASPEEGLPKYAQALREANKVIVIFLVVVIMLAVGCVVTVDDFKSTLRRPVGVIIGFLSQFVVLPLTAFGLAHALKLNAAYALGLLVSATCPGGVTSNLFAYWMDGDVCLSITMTTLSTVAAMGMMPLNLFLYGRSWTSESVVIPYSNIAIALALTLVPVAAGMLIKYRKPSWCKIITLLGSIFGFLAIFFTISSGGIIDPSMFASPWQVWFAGAIQPLLGYALGYFFALALRRPHAECRTISIETGTQNIGLALVLLLVTFQGSDQLNNLLVIPNVYRGVLALHSLWLTGLYLAWKRWCRGVSGAQDHHGSPLAQQSEEPGKDRCEMENYNHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQM0</accession>
    <name>A0A8B7XQM0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Group XV phospholipase A2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082467.1">
        <property type="nucleotide sequence ID" value="XM_022226775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQM0"/>
    <dbReference type="GeneID" id="110974865"/>
    <dbReference type="KEGG" id="aplc:110974865"/>
    <dbReference type="OMA" id="QMTPPGV"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034909384" evidence="1">
        <location>
            <begin position="29"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022082467.1"/>
        </source>
    </evidence>
    <sequence length="418" mass="47534" checksum="CD782AC4F4AC5FC1" modified="2022-01-19" version="1">MEARTTTAIWPKLLSALTFIWWFSVVLSTQTGKVPPTKGYPVILIPGDGGTQLWASIDKPSTVHYVCRQKESLFNLWLNVEELIPLLIDCFVDNARLVYNNVTRTTSDSPGVNVTVIDFGNTSSVEYLDPSKISLSKYFVGIVDALVAVGYERGVSVRGAPYDFRKAPNEAQDFFRNLTSLIEDTYRLNGNRKIVLLTHSLGCVYALYFLNRQSDPWKAKYIQAFAPIAGPWAGATKSLRVTMSGDNLGDFVVSAVDVRKAQRSWPSLSFLLPSDRFWGPDEVIIQTQKRNYTVKDYQALMNDLNYEVGWEIYKDVRDLIYDLKPPGVPVYGIHGRDVKTEQFYLYNKEKPFPDYQPYITYGQGDGTVNMRSLKAYMRWQHEQQQPVSEFEISGGEHVAILQNTTLFKYIIDTVLHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRZ6</accession>
    <name>A0A8B7XRZ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Fibrillin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110975130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082962.1">
        <property type="nucleotide sequence ID" value="XM_022227270.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975130"/>
    <dbReference type="KEGG" id="aplc:110975130"/>
    <dbReference type="OMA" id="GTGYHYK"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000003">
        <property type="entry name" value="fibrillin-1 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000002">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000115">
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        <property type="entry name" value="TGF-beta binding (TB) domain"/>
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    <keyword evidence="4 9" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSQ3</accession>
    <name>A0A8B7XSQ3_ACAPL</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <begin position="1885"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083899.1"/>
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    <sequence length="3218" mass="351794" checksum="9A32EB08D3B2F9F6" modified="2022-01-19" version="1">MDGQGDDWSVDGTLPQFLATVPNRLSPAHNFELQGSSSHLSHSLRNAQDALEFFKQPQQSSLSPFTNQSLDTELPDFCKLPWDSTEQSSSDLGDSVRVPSLDVENLCYGDSGEAKAAQLENNEQLKSVGLCLSAENESSWSCDMSSSELHSAPRSRSYDNPSHTVAGQEAHLADELLLPTPTVVESENECIGQNCDLIPPVNPFSQLAMQTKKSSDQYYQSLPLANEYVGLVTEPCIQARDDSCHAASNFGSTPQKNEENIPMQSSLLTTVHQTSSDVLHPNARHCQSRDYLTNAGQTTQDFISIESNLSDGGINETDEGIKISDDFSLNYDPPSFSDGDSDIKSPELSADLTRISNNAEQWCFDPSSLQDEEHSSGITNVQDGSSLSPVSPERSFQDIVGSGGQQKQEIETQNKDEISPCSTYLGCSTVSESNCSLLQLDTNNKDIQESRQNGSPVDEKDPQLSQNTSSSALTRFVNVPSTKEASEISSHELELASELIAKTSTGSVTDTRSFQLNSNKLSPGQHDGKIGSDLNKLQHDISPVPNSGSSDSLSPRQSEDDASSLRERDNSLSSEESVLLISDFECDAEIADNKTQDTPINVKIKNLPSPDEACQNKTIERTEPDSTTRILDHQGDTKPEARSSHVQVCKGQMEGNLTNDDSLLCNSPSDASFDTGATLSSDRYTTESPGHMSGNGAYETVSYEEKNGSPDKDTSVVGEETERTLSEDKNGEHKLMATATDSDVEEAEAELGGDCCHVDNFHFNEEVEGDKQDPCIVKDDSKFGRKEDFANGSNEDKLGKEHKLIATATDSDIEEAEAELGGDCCHVDNFHFNEEVEGDEQDQCIVKDDSKLRRKEDFVNGSNEDKLGKEGCYIEMLKEGDAKSDVYCLQDTNASKQREAGAEKEVSEVAAIHKHPKGDLGDVSLRTEDPDFPGNSECLQDPDASKQRDEGTEKEVLGIGPRSQDLCQEKNTSSEGVGEWESPVAGIHEHLKGDQGDVSERTEDPDSPSNSECLQDTDASKQQDKDTEKEVLGVGRRSQYLCQERNTSSESVGGMEFSLASIHEHPKGDLHVGDVSLRTEDPDSPSNSECLQDTDASKQQDEGTEKEVLGVWWRSQDLCQERNTSSESVGGMEFSLASIHEHPKGDQGYVSHRTEEPESPSNSEKKSPNQNAVRKTTDTDPVTFEGSFSKLGKISASLQEKENTNVNPQMPEGESHKKSDDDIIILDDDPEVISIGSSDEDEGTESSASKQKQLTTATTRSPSKTTVKTPPQQNTQWACHICGDHNKTLNSLKLHVRRVHNLIMVHRKEDMKCKLCSFVGTWQKIKEHIINDHDTPLKWYIKNHETREITKLPLSASVPSETPQSQGNNTAGAQASHPAKVIAQKTAAPASKQHYLIKRVSNISMDGQDERLLSVKTKDKQMLPSSKVLTLSHNTPSLSAQPVGLSITPKVSSVMNVHTPTVSQVQVCPATTVPKLNTQNKVIIIRHATPAAATKTVSIVTTGKNAVVTQGGVHNNSRNLYPVVPSVVHDQQGTKTTPTLLRSKVGNSVIAPPVTKTGVEQTIQVSAVVTHYSTRQITYRANTGKQYKIMTSPVSPKQQIITASGLPSSLVVPRKTAPQGLGVSTASSQVMEKVRNVSGTSQPASQQNPKTFFRIFSNQTAQGSPNNTRALTDAAKAPINFIKSSNASAPAKTMPLSKQSFTYSVSALPNTVSNSSTLSKLGLNSLPSSGIRASAVHVPSTMTIIKTVPHLASQHVSGASVNQSSASVANQKVQTVTTPSSGLVTSSKEMPNITVQRHLLDGDSMASYVIRVPKSQSESMMHSLSNSGKKHDDSLYLVKVPVNHTDSPKKFMVHLPVEKGSTMKHAVCIVQPPAGESDREVSPVFSKSSTSNSHQGKPVSLLDGLSTSLGQIKSISPMSVGLIAKTSDVSSVVPLCVTKAKKDPTKKAECLAHLQEPAVNIQLLEDQFKNTEMFKAADLIKLDSRVQFECARCKEAFPQLMLLQLHHIDCTAHPPSQKILPIVHIPTAVLAAFFTLSASGYSSACVICKVLLLGNARHMEDQQDFCSHLSKHTEPRVAITSLDDTRKLGILQTRMTSQQAKEWVDYLVPPFKMCNKPTSAYDGSLDEYICTGGILHRESVKRSQHKRSLSPETRRREKHKKHKKHKRHRTPHIEISGRSNEGTRNLYQSSLKTAEGCEGEWIEPSPKDSGKLWVRRKPRAGGLKESIMTSPSHPKLLQHGMRVNLSKSAKTSPSKTSQRFLNVKIPGRRSQRGMGLDFGQGLVMLPMTTRKRKKKTDEVAKEQMSGILTRKVNMTPAAPSCSSVLGDKEDLVGPGESSMSNKSTGRHASKIPTVSSVQGQEDNTEVGTDIQTKDPTDDIVVITSSDDDGDDAEAKEDDTQDGDKSMHTNMIEGNSEEPNIGKVDADEESDSKDAASDNPYDDSDSSLNENANGQQSDSDEDIDDDKDGMNQRDIPLTMMALHYRRLNEEMAKTSQEKQDSEEVTCESPSLTLSVDKLEEDTETQTAGDQDAEKTTESHPTWEIVGAVTSDKLQDSCSSHRLKVISPVPTSDCSNLSGEFSSQSSGSLHSNINVESSTVESESLESEEFHPNKQVKQSTSQHSNSSSTCTQFGESSGSKPEETLPSEPCKDTGSELLREEKDMISPQRGIVDNDLKDNTSGASDQENCISDIEDHDPSSEIESLEDAISNVMATDNLQDLKSDTLDKVSVEGSFGSENRDQDNVIFVAADISDTKNSDNSHSMETLSEMGNVKEQSVEDLEGNSRDDDIKDHTTEDSKSGSNISEIKIPSCTYSNIQDSWINNATDGVTQINNDFRATLLENDSSGESKSADETWKRKSQKDTVSEDHNLKDSIQKDKSLKENDWKTDIWKEDIPMTSNLKEHSQADVIQNVGTKGDATLNDMSGKGSVYADGISWDSCVSNAESSVQRDRFFREKNLTKNNVSDGSQTDEAVEQVTCTTEEEESDITNETKERDRFFSERSLDIEDSFGSQCNDRLFVGGVCDDISCMSYPKEDIRQDQQSDGLCGQDSGAGETQEEGQETRLYQDDDQDSDDDVICLIDDSDEEFQSLLSTDQFPGLEWAPSTVHTVKEQTVWSTSADHPSQTLGKPVVKQVRGHSLKRKSSHDYEDDELDSDSDSPWKHARGREACDEATPSDSWRLLEVSEESEEHSAAEMVWKQDRGTSVFTHEDVGQLRAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUL6</accession>
    <name>A0A8B7XUL6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Glutathione synthetase</fullName>
            <shortName evidence="15">GSH-S</shortName>
            <ecNumber evidence="4 15">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21 22" type="primary">LOC110975626</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes. Participates in ophthalmate biosynthesis in hepatocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:72075"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:189406"/>
            <dbReference type="ChEBI" id="CHEBI:189750"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:72076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13558"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="4 15"/>
    <dbReference type="RefSeq" id="XP_022083931.1">
        <property type="nucleotide sequence ID" value="XM_022228239.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083932.1">
        <property type="nucleotide sequence ID" value="XM_022228240.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083933.1">
        <property type="nucleotide sequence ID" value="XM_022228241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUL6"/>
    <dbReference type="GeneID" id="110975626"/>
    <dbReference type="KEGG" id="aplc:110975626"/>
    <dbReference type="OMA" id="NGLVMYP"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="11 15 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="18">
        <location>
            <begin position="213"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022083931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022083932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022083933.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="54365" checksum="562FB80A818ECC05" modified="2022-01-19" version="1">MATSSSLEPSVPLPLSPDILNDLQESSKDWALTHGLVVMYMSPDQICCPDRITYVPHTLLPSPIPRQLFERMVSLQPHINLLMHRVAEDREFMTSALKSTIKVDDFTAKLFEIYEEMHQAGFTKPVKLTLLRSDYMIDTSGPQQVMKQVEINTMASSFGGLAANLTHLHKYNLGLHSGAQSNFEDNLPKNESLEALAEGMVKAWQLYGRTEAVVCYVVCCPEQNIFDQRLLEFMMKKKVPCIRVIRRGLSEMGKKGHLSEDRRLFVDGLEVAVVYYRVGYVPSHFCCGEKAWDAKLLAEKSLAVTCPSIDWHLAGTKKIQQELSRPGVLEKFLDDPAIIADIRATFAGQYHLELDEEGDAAAIMGIRDPERYVLKPQREGGGNNFFGDELMQTLTELQGKEERAAYILMERIHPQVISNYEVRGNQPVQLKDMVSELGIFGIFVSKSSDVVMNTCAGHLLRTKNVKINEGGLAMGASCMDSPYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUY9</accession>
    <name>A0A8B7XUY9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IQ calmodulin-binding motif-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084664.1">
        <property type="nucleotide sequence ID" value="XM_022228972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUY9"/>
    <dbReference type="GeneID" id="110976034"/>
    <dbReference type="KEGG" id="aplc:110976034"/>
    <dbReference type="CTD" id="9657"/>
    <dbReference type="OMA" id="DDYIRLH"/>
    <dbReference type="OrthoDB" id="8178106at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028765">
        <property type="entry name" value="IQCB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15673">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15673:SF2">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084664.1"/>
        </source>
    </evidence>
    <sequence length="587" mass="67819" checksum="69CEA9A3D3E92C33" modified="2022-01-19" version="1">MSGADTLEDRRVEDLAHQVTETSDKNVPILLLAIQDILDSVIPGSQRAAKVKKDIWQFDLLQSVLLALRQDFSLIQGKWNTAASLAKILAHCAVGLEPTDTYEYNAIFLPEASERLLILARNVQFRYMKIPEKTLTLKDDLIKDFQEVIEALQWLISGHVFLTMHVLRSNYLLQMLITDDKETAIVILGLFQNAVRVNPVVLQTLDEKVVHSLLDEVIYKLSAFTEAEVGAAATRTLVNIADVHQPLIRLLYTRYKGLRPLLSRWTGKGFGRDLKKLLALLDAGSTQQAELQRLHRAARTVQAVWRGFQTRKQLKKANKAFTRLQKSFREKQAQRDQQVEKERERRELQHQLLVSRRQAIRQTRQKQLDMIAAMAPGKVDRYLQMSQIAAAVKLQARWRGILERRKLGLRKATAQQVRAAITIQRVVRRFLKKLEEKKREPLLFRPPPGLTEERRVDLQRTIDQHREAHPPKQLSYQLQQELHNEAQEMLGRYLSVRMAHRKSYQRREALLASLETDADLLSDAPKLCDLTDRDIHKFTSHSAPIATKALANHKEQMVMLRQPWWKKLNADERTDEEAEQDYDSNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV42</accession>
    <name>A0A8B7XV42_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110976070 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084728.1">
        <property type="nucleotide sequence ID" value="XM_022229036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XV42"/>
    <dbReference type="GeneID" id="110976070"/>
    <dbReference type="KEGG" id="aplc:110976070"/>
    <dbReference type="OrthoDB" id="10459368at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034215127" evidence="1">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084728.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12577" checksum="72B769F262115292" modified="2022-01-19" version="1">MGFMPVRLPSLKLVVLIVLATVLILNTSTANGTLCSSLHCVDVSSPACKFCNRRVGKRTENYAWRDDRDTNKPNDVKRGIATPECYLDTVVGSLPHELQEQVFEVLEVVLNMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVA3</accession>
    <name>A0A8B7XVA3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein NDRG3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083945.1">
        <property type="nucleotide sequence ID" value="XM_022228253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVA3"/>
    <dbReference type="GeneID" id="110975634"/>
    <dbReference type="KEGG" id="aplc:110975634"/>
    <dbReference type="OrthoDB" id="741027at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000047">
        <property type="entry name" value="protein NDRG3 isoform X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083945.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="48528" checksum="B2592FDE64F3298A" modified="2022-01-19" version="1">MQTGEKPGMYCSTMTSPRHKVGATSSIQYKMSYHKLAGSEPEEGEVNLTHVQAEVPQDTYQRLDSDQPAVPAAMELFKVEVTDAKARNFDGFEDTNKSPLLKEDGEKTVPYELVYVPDDNGIMLVAVQGDKTKPAIITYHDIGLNHVTCFQGFFNFPDMTPILKQCCVYHVNAPGQEQGAHQLPEGKPYPDMDTLGEMLMSVVKHFGLKKFIGFGVGAGANILARFELAHPQLVEGLVLVNCTSKPATWGEWGQQKLSSFYLRGKGMTSYSQEYLLWHYFGKKTMESNHDLVTVFRENLAKSVNPYNLSLFIDSYIRRTDLKIKRELDPVKKKATRTLKGAIMLIGGSNSPHLNDTVEMNARLDPENSTWIKMSDCGGMILEEQPAKLCESFRLFLQGLGYADVLKIRATRPAQSAESSDLHVTSKSKGAPSPVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVB8</accession>
    <name>A0A8B7XVB8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein Hsp-16.1/Hsp-16.11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084808.1">
        <property type="nucleotide sequence ID" value="XM_022229116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVB8"/>
    <dbReference type="GeneID" id="110976108"/>
    <dbReference type="KEGG" id="aplc:110976108"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06526">
        <property type="entry name" value="metazoan_ACD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001436">
        <property type="entry name" value="Alpha-crystallin/sHSP_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640:SF13">
        <property type="entry name" value="HEAT SHOCK PROTEIN 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45640">
        <property type="entry name" value="HEAT SHOCK PROTEIN HSP-12.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00299">
        <property type="entry name" value="ACRYSTALLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="5">
        <location>
            <begin position="98"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022084808.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="24800" checksum="6604CDACFD82F635" modified="2022-01-19" version="1">MSSHWKIVPTFGLADQLSRDMYEDMGIHRFFNDQYMDGTFHAWPWTAHSGLRRSLGGNFDEVYRRHWDGFTRDLLDNYGVRILCDRHGTPTETERTAEATGVGDKALAISRPEHGFKVALDLSGFTPEEISVKIVDNNTLRVAAKHEEQTQGRSVQRSYTREFTLPTDVNLEALKSSLDAGGVLSLKAPGRGEAERAVPIEHVAAGEKSSEALKDAPKDDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY07</accession>
    <name>A0A8B7XY07_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-binding protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084920.1">
        <property type="nucleotide sequence ID" value="XM_022229228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XY07"/>
    <dbReference type="GeneID" id="110976168"/>
    <dbReference type="KEGG" id="aplc:110976168"/>
    <dbReference type="OMA" id="ITYDSHA"/>
    <dbReference type="OrthoDB" id="443401at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12257">
        <property type="entry name" value="RRM1_RBM26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000208">
        <property type="entry name" value="RNA-binding protein 27 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045137">
        <property type="entry name" value="RBM26/27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398">
        <property type="entry name" value="RNA RECOGNITION RRM/RNP DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14398:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN SWM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14605">
        <property type="entry name" value="Nup35_RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="2">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="81"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="773"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="987"/>
            <end position="1028"/>
        </location>
    </feature>
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        <location>
            <begin position="1124"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="851"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
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        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="243"/>
        </location>
    </feature>
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        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
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            <begin position="328"/>
            <end position="367"/>
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            <end position="405"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="4">
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            <begin position="412"/>
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        <location>
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            <end position="485"/>
        </location>
    </feature>
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        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
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        <location>
            <begin position="605"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="994"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1124"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022084920.1"/>
        </source>
    </evidence>
    <sequence length="1144" mass="126038" checksum="66DC3BBAF51C67AA" modified="2022-01-19" version="1">MPVIIPNVEKLKAWLKRKLEPICEADPVPLSKYVVALVKKEKSEEELKEICKAQLEVFLVNETDGFVNELFEAIMTKSYLTQDGSVPGGDTQQEGNKDRPADQSASDVTGEGQPPQPPLSDADVSLLQSEAVSTMRSNEAARRSLEAAGEGGEKDHRRPRRSRSRSRSHSPGRRRRPRDDDRYRRRGDRFDRHGSRYHSDRDRDRERERNRDRGFRGYRSNRDRPYSDRRDDRREDRRDDAGGHRTRSRSRSRSRSRSPVPVTGAGSVNSIITVVGGGEGNQSGLRPRDRCRDYDEKGFCMRGELCPFDHGNDPVIVEDVNILKQRTPPLPAQPPPSQPPPPQINSQMPPPQPGMLPRPPLGPPPPGGQYGDPFPVGQRLGPPPQQPPPARMPAPPRGPMLPPPHSQGGPFPGGPPPMAGGPPPMLRGPPPMGRGMPPIHPSQPPPLAGGPGQLPPPHMGMRGQMPPRGPMPPRGPMPPQGPPGPDHNELRPMPRQGVHPIRPVGPPLHQGHPPTRPNLPPATFQERAPRMDAPKGRFAPSSDGQPQPDAYNPEDPSIDAKPYYVPRSGRNQSANLRSLIGVQTVPLAEPKDIEELEAETKKLDTGSTRTVVMETPESTGSQQASDSRTVVAASSSTANATGRKRPHEPDTSQEGGSGASSSPSKTMTPDSTRKVVSGVGSSSGWRPKAKVTHSSRTLEIRKIPRELNSIAKLNEHFQKFGVITNLQVAYGGQPDAALITYDTHLQARAAHNSIEAVLNNRFIKVFWHNENAGQDGSDASSQSPGQGSSSKGSVKDRLGIPTKDQLTFVKNPPETSERVVVKSTGTGLSKTVFNPAALKAPQASLLAARKVAAAQEAVRKKQEEQRKLAQKKQVEIRRQKQELLVKLIQQQKSFLTKLEDKSLSADKRAEILSFVKKLAEQVDEIKKALEAKPLTKSKTDVQKELLDTELELYNQQSDGGDATELYRRVAQLKREISTRTASLNYMNAASRGGARGRGRGRGRARRLSHSSTTIDKRPRTLGISGFDPEDKDEVLTHFSDLGEIENVVYDEALHTYVIGFKTRKEAEFAVKKGGLFKDRQLQMVWHTPQQTPLAGEAEPDVEEDIIEVGGELEDDEDLDDINEDLLLEDDEEDDEDAESRGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZ61</accession>
    <name>A0A8B7XZ61_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Protein crumbs-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110976401</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="15">Interacts (via Sushi domain 21) with ITGA9:ITGB1; thereby inhibits Ca(2+) intracellular signaling and as a result represses vasocontraction. Interacts (via Sushi domain 21) with ITGA4:ITGB1; thereby inhibits Ca(2+) intracellular signaling and as a result represses vasocontraction. Interacts with ANGPT1 and ANGPT2. Interacts with PEAR1 (via extracellular domain). Interacts with HSPG2, TLN1, FN1, COPA, CCT2, IQGAP1, LAMC1 and NID1. Interacts (via C-terminus) with TIE1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085320.1">
        <property type="nucleotide sequence ID" value="XM_022229628.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976401"/>
    <dbReference type="KEGG" id="aplc:110976401"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003013">
        <property type="term" value="P:circulatory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009792">
        <property type="term" value="P:embryo development ending in birth or egg hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002064">
        <property type="term" value="P:epithelial cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060562">
        <property type="term" value="P:epithelial tube morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048592">
        <property type="term" value="P:eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048871">
        <property type="term" value="P:multicellular organismal-level homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="2100"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="2141"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="2178"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="2214"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="2258"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="2297"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="2335"/>
            <end position="2344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="2413"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="2456"/>
            <end position="2465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022085320.1"/>
        </source>
    </evidence>
    <sequence length="2539" mass="272871" checksum="548B7D611FE96BE2" modified="2022-01-19" version="1">MDSTEQKKGLVVVLLAIICVCFGSFHPTLAQNAPASKVYFNVSSYVNISTVLNLQSSLGTWLNFRTCDEGEILTQTGSNGDTFTLSVIPSGFVRATWTVGAVSKSADLGPNYATNTKWLLLRLQFALGSIILTVDDNSTTLASASMNSELLAIDLSGGSDVILGVDFVGCMEQVTGLLLDSATSWSNVEWGVCPLEMQQGCQPPVRNPCYTHPCKNDGVCYTNTQAPSGYTCDCTARYEGENCEIDKGPLCNNPAYSLDCQNGGICLEDDIGNSTYCQCTGQFEGLLCERNKTFVCSSDTCLNNATCRATDTGVQCECALGFSGDDCGINIDECAVHQCLNGGRCIDGIDGYTCNCTGTGYTGDRCSQHVNECDVQPCQNNSTCVDTSGGFVCVCSVGWTGKTCDTDVNECESFPCLNGATCVNLINAVYECQCVQGFNGTNCELNIDDCTSEACPPTFVCVDGVDAFTCECPPGKVVNESGSCEDFDECSLNPCLNGECENLDNNYQCTCSPGFNGTNCEMNIDECDPDPCLMNSTCVDGINGFNCTCLPGYNGELCNVDIDECLLLPCLNSATCVDGVNSFTCECVPGFEGERCENNTNDCLPNPCLNGATCVDEVNDYTCNCIPGFTDKNCSTDIDECQSNQCQNSGTCVDLVNGYQCNCTIDYVGEMCEMLYDACDIRKPCQNGATCTTPPLPSQEYTCTCVPGFNGTNCEINIDDCLGHDCNATLGLVCFDEVNGYRCACPVGFEGPVCADDINECAENPCGNNGTCNDYIGFYNCTCASGFAGVNCEEDIDECNSNPCLNGVCFDDINSYQCYCRPGYSGDNCEVTLNECDSDPCFNGATCIDKLNDVECNCVPGYTGSRCEINIDECDPMPCKNNSTCEDGINEFTCNCAPGYNGTLCEIDIDECAVNPCNLGSCIDGINNYTCNCSFTGFFGPQCENNIDDCAPNPCLNNATCQDLIKDYNCSCWQGYEGKDCSEDINECLDPPPCLNGGMCYQRSNQSLYNGNHPLFPGEFSYANASGFVCQCAPGYEGETCSIDIDECAVDPCANNGTCVDGVNSYTCTCAGGWEGLNCTIEIDECLPEPCKNGATCIDLIDDYECTCTEEYAGRNCTELLTGCVNNTCLNGATCIPSYDETTDTHSFTCQCAAGYTGNSCQTDTSVSFENESYLEDRSTFDHTTLDYSLALQTTLPNGILLYSGQSPSDRFFLLEMFNGDLFLKYTSGGVTVEINDFGQEINDGVYRTVRVVVTAETISLSVTVPQSRRARRTATCAGGVCEQTINIPTSTQVRFGYMYIGGVPDSISGAFFYSQSEEFFTGCMRDIQNEGAYVMPPNTRAAVAPSGCTRVVQCPADRCNYRGVCTDLWTTFRCDCDIGYAGTTCNESFIPATFRFEDAPESYAEFTVDDTLSSSSSAIRLAFRTREPDGLIFFTRDVFSNSHITIEVVDETLTVTASRNSSPTSVILGQGLSNGQYHFVSVTADQTELRVILNPGESELTDTKALMSGDPDFVDFSVGGVADFTALDPDAIVSDTYFKGCLWDVKVNNYSLQFEPLSLPDFPIPSFPMTTNASVLINDCQSDDTCADLPCENGGTCEVTWNDFKCHCPSGFGGKNCSELTICAKENVCPPEAECKDLPDGHECVVDATFNGVSSLVTYTSNISQSTVLNSITLRARTRSDAGIIYHSSNNLTNYFVTLYLDQGKPALRFNLGQTGDIVELVSRVSIKDGSWHDIKVEFSTARVEISVAQISETIASDIQSDFLASVITSEGSSPVHVAGTTMVNNDYFINYNHFKGCLDEVRVGGILLPFYSRDTINSTSEEQFEATIVNVATPCMSEPGVCDSHFCSNSGTCLDVWNDAECQCAPGFTGDRCQIDINECMANPCVMGSTCRDEINNYTCLCLPGYEGRNCDTETNECDPNPCLQGSVCYDGVDFFNCTCLDGYTGTLCDVLINETCAGNPCKNDATCRDTPGSEVKFECLCPNGFDGDDCGQEIDYCVAHRCANGATCNSLRDEGTYSCSCTDGFSGDLCEINEDDCGGVTCQNGGSCVDEIKDYYCNCTAGYEGKFCQNDINECNPNPCQFGATCDDLLNDFNCVCTPGFEGQFCSVDINECLVAPNPLCQNGGICMNTVGSYECICPMDTYGPQCQISPCDPSPCENNATCTTQPRGVYDCLCPLGYEGVNCSVANCSIAGCQNGGTCLLGDGSWECKCAELDAGPLCQYKGPCSLDIDPCLNGGSCNQTFQDDGSFSYMCRCPVGFNGTNCELKINWCDSNPCLHEGSNCTSTTDTFLCSCGPGYTGTFCEIKLPDCASNLCQNGATCQDLDYGYKCHCADGYSGDDCETDIDECAVEPCENGGNCTDAVNDFICNCTGTGYQGNTCSEDVDECTTLSPCLNNGTCANSPGSFKCTCQSGWLPPVCFLADPCVGKPCKNGGRCDYAVSPDGQSVEWKCVCSADYDGDKCDTFIGNETNWALIGGVTGGAVVLLIIVIVLGIFLINVKNKRATRGTYSPSRQEISSSRVEMDNILKLPPEERLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y066</accession>
    <name>A0A8B7Y066_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110976430</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110976430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085381.1">
        <property type="nucleotide sequence ID" value="XM_022229689.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085382.1">
        <property type="nucleotide sequence ID" value="XM_022229690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y066"/>
    <dbReference type="GeneID" id="110976430"/>
    <dbReference type="KEGG" id="aplc:110976430"/>
    <dbReference type="OMA" id="HENCNEQ"/>
    <dbReference type="OrthoDB" id="10467504at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022085381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085382.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="42035" checksum="951F83F2E2AE2D2D" modified="2022-01-19" version="1">MLRHLRSSCSETDISMEHRPSVDSNGYVDPFYITRHFNRLNLKRLSLSHPNLNIGLKGSITPPSGLKGKVSAAVERLERVLTGRTSFGRTFSQESQQSTSNGWNSDLPGSPSDSDAAVYTYKKQQRCDLNRENGYMTFDPELNPPLPRPRRVLSSSCSSAPSSPGFQERCNTGFEDVTCNTGCEEESIYESLDNYSPRHRASTLKSLPSSEGETPPEVPPRPPSHRLRQRQRVLRRQMPLPPIPTAHSTSILKDRSPVPIMTTSSAGNINTVQHSLNKTSGCRNNFVTGQSSSCSTLPFLRMDSSEEDSVFEVHMENTAGSKIRKGKTTEDTQVCVGVKDEKNINEKCQKGSVTNTNKSEKQVEGHAAIVYENEATVNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1D5</accession>
    <name>A0A8B7Y1D5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Allatostatin-A receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110976931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086337.1">
        <property type="nucleotide sequence ID" value="XM_022230645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1D5"/>
    <dbReference type="GeneID" id="110976931"/>
    <dbReference type="KEGG" id="aplc:110976931"/>
    <dbReference type="OMA" id="CVTMERF"/>
    <dbReference type="OrthoDB" id="5950491at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="73"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022086337.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="42098" checksum="B4A106BBAC7AFFAB" modified="2022-01-19" version="1">MTTETYRPMTDSWLTETLVTALDGHRHSEKDGSGGGAGVSGGDETQGWGVGGIENSIPVRITYTIIACLGIAGNFIVIFALIKVPSLRNCTSYFIIHLAATDLITSIWVIPFHMLSVVPHIPEGLGGELVCRLFLSKYPLWVTIFASVYSMVCVTMERFFAVVYPLKYKALYTTSRIVPMIVSCWLVGAVSNWFFFYNYDYVSGKGCIFVSWPSSAVSAVIGVYIFAVVYFIPITTMLVAHWKMIKSLKKQASSLEGKACRGGACKKQAWQLQVAQDLSRMLLVVVVTYAACWLPNQVLFLAYNLGVPVSFASLPFHLSVILALCNSCINPFIYTLKNEQFRNGVRKALCLRATGVVEPAANSLEGAEQRTANTRSTNVESIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2E5</accession>
    <name>A0A8B7Y2E5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 13 member 5-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110977022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086470.1">
        <property type="nucleotide sequence ID" value="XM_022230778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2E5"/>
    <dbReference type="GeneID" id="110977022"/>
    <dbReference type="KEGG" id="aplc:110977022"/>
    <dbReference type="OMA" id="MTSHEIG"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015556">
        <property type="term" value="F:C4-dicarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF82">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="529"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086470.1"/>
        </source>
    </evidence>
    <sequence length="652" mass="72020" checksum="0ACF5F61D35AC668" modified="2022-01-19" version="1">MHIEPKLSTVARLIPVYIHERETAWLVLLILEMTSHVDPPPSWEEVIGPAEEQEVDGPGELPLPAPSRRALIWRNRRYFIVFLVPLILCPIPIVFNEPIGYTAYSILIMAIFWCTEAISLAVTALLPLVLFPLFGVMPAKDVAVQYFKDTNLLFFGGLMVAVAIEDCNLHRRIALAVLILVGSKPRWMMFGFMIITAFLSMWISNTATTAMMLPIAQAVLQQLKRDNLKQDTDNIESVEDVTANERSHSKSEEDVVIEMEQIQPNGTSRTRLHSLKMSSQNLQEDNEQEARYNLMCKGIVLCVPYAANIGGTATLTGTGPNLVMAGQVSSLFGSEAEVNFGEWMMYATPGMLLCLLLTWIWLQIVYVDRWCCRKLGGELDHKGAAKVIRQAYKDLGPMSFAEVGVLCHFVLLIVLWITREPGFVTGWSVLFLEDYVTDSTTVLFVAILLFVFPSRMPKFLCGRSSKEDLLEEKSPCPALLEWPVIHKKMAWLVVILLGGGFALAEGCKVSGLSAWIGDKFAVLDSLPPFAIALVVSVIIAGFTEVTSNVATATIFLPILASLGTSIGVNPLFLMLPATVACSFAFMLPVATPPNAIAFAYEQVTVMDMVKTGFMLNVICVFVANASINTLGMWIFDVGTFPDWAKVNVTAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3T2</accession>
    <name>A0A8B7Y3T2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110977055</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022086536.1">
        <property type="nucleotide sequence ID" value="XM_022230844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3T2"/>
    <dbReference type="GeneID" id="110977055"/>
    <dbReference type="KEGG" id="aplc:110977055"/>
    <dbReference type="CTD" id="2805"/>
    <dbReference type="OMA" id="GTWTHIT"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="44"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022086536.1"/>
        </source>
    </evidence>
    <sequence length="424" mass="47648" checksum="082D3E4C3998EC51" modified="2022-01-19" version="1">MADLTNDEKKPRLAGSRFAGVQQAAPIPVFALTAAYKEDTSATKYNLGVGAYRTDEGEPWVLPVVREIEKQLAADESLNHEYLPILGLAEFTSAATKMLLGENSPAILENRAFGIQSLSGTGAIRLGCEFLIDHLNYKVPYVSDPTWQNHVNIFNKLKYENVRKYRYWNAGTRSLDIEGMLEDLENAPEDSVIMLHACAHNPTGVDPTKEQWKRIAEVIQRRKLFPFFDCAYIGFATGDIERDSWAVNHFVSLGMEMMASMSFSKNFGLYNERVGNLICIVNNVDTKSAILSRLTRIIRTTYSNPPSHGARIVSTALNNPVYFAKWKEHIKTMSGRIFEMRQALYQRLQSLGTPGKWSHIVDQIGMFSYTGLGPNQVDFLLKKYHIYAMKSGRINMCALTTKNADYVAKAIHEAVTTVAEDPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y458</accession>
    <name>A0A8B7Y458_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 9-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110977821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087968.1">
        <property type="nucleotide sequence ID" value="XM_022232276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y458"/>
    <dbReference type="GeneID" id="110977821"/>
    <dbReference type="KEGG" id="aplc:110977821"/>
    <dbReference type="OMA" id="YCITSNT"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000018">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022087968.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="27281" checksum="08BF4832C8E05DF8" modified="2022-01-19" version="1">MAAPQVKAVPKDAEVMVAILKDMGITEYEPRLVNQMLEFTYRYVTDVLEDAQAYSSHAGRTEIDSDDVKLAIQSRLDHSFTTPPPREFLMEIARQKNNNPLPAIKPHNGLRLPPDRYCLSGSNYRLKPLHKRATLTMPSRLSLGSGMSMASSAGSKLSPSFTFGGKSPYSVTVRAPVSSKAGGAPISIIKSVSRSSATPTITMQPGSTAQRAPSGSTSGAPLTVIKTQVVSPPPSQSSIVNPAKRKREEEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y463</accession>
    <name>A0A8B7Y463_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine-rich repeat and calponin homology domain-containing protein 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087973.1">
        <property type="nucleotide sequence ID" value="XM_022232281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y463"/>
    <dbReference type="GeneID" id="110977824"/>
    <dbReference type="KEGG" id="aplc:110977824"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21205">
        <property type="entry name" value="CH_LRCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000067">
        <property type="entry name" value="Leucine-rich repeat and calponin homology domain-containing protein 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF21">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="768"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="486"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022087973.1"/>
        </source>
    </evidence>
    <sequence length="891" mass="99573" checksum="C48F931F74698060" modified="2022-01-19" version="1">MAVPVSHHLGGAQLRSLEKVLDDAHMTGILNLSGRNMRDFPKSADNFDLMDTVDVDISKNRFMEVPYELCEYVSLERLNCYNNAIRTVPDAFARLTMLTYLNLSRNSLSALPIEICEIYLEVLIVSNNKLVALPPAVGKMKTLMHLDASCNELDTLPIQIGEMESLKELNLRRNHLMQLPEEISRLPLVMLDVSCNKITFIPPSYRHIKTLDILKLEHNPLEMPPAQVCTRGKVHIFKYLNNVATKDERRSRLEQNERLSRRSYNNAKYTWLATHEAATRFGSAHNNNLDTNQAGNQSVILSPSTLTAQYVKGSEGTNGSPRSSALTPQSSIDSDSSHSTLCNGDLSVAEELAFWNAKIGELRRGTLTADSGYIDGDKRWSATEPSNDDEEARILADRANQQKELRQQRGELLNQSLSSGNSSFGADNEADIDYIDTGEDGMEDGEITPTQTEPDEFTKALTRQKAIYEDQKLKAREELVRQEEAERQWQQEEERWKTERRREAEQERYRRSSPSGSLLSVNANGNVVNRGGERSQKPRPLSSSSFSECLQRPTTLEINRQKRQQRRATVNVADNIRSSSVDRNSYNRMSSGHSSNLPNGRLPSATSDSHRQLKRADKMTTSSSSSLAPSRDSGISQSRHEAQLARRRQEEEKARNKQIQKEAVRNFVQSRNSTSSLGSPGHEEQDLVRERSPASAKSPPPPPPTTYSGSAFGSIKPRSAFNIGSGKPQGDVQPNFTVKREMNKYREEMDRIEQLRKLKPNWMSSYQSVSDINTIDQMRKCIEARLKVTLPDDIPGALEDGVVLCHFMNNVFPHAVPTIHVPSPAVPKLSSAKCRRNVENFLKACSNAGVPGEKLCTSADILEGKGLVKVAATVQSLLANTPSHHKLSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5W5</accession>
    <name>A0A8B7Y5W5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2 3">Branched-chain-amino-acid aminotransferase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">LOC110977701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087740.1">
        <property type="nucleotide sequence ID" value="XM_022232048.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087748.1">
        <property type="nucleotide sequence ID" value="XM_022232056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y5W5"/>
    <dbReference type="GeneID" id="110977701"/>
    <dbReference type="KEGG" id="aplc:110977701"/>
    <dbReference type="OMA" id="QCIHEPF"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022087740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087748.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33812" checksum="A472E90549067E1A" modified="2022-01-19" version="1">MEEQGFFTSQSPVILDRVTADDSPPPQPPVRVMLWCVPRSVSTAFLKCIDGMDRPAEIFHEPYSVAYYFGPERRAPPGPPIPEERQYTYSWVRKQLEADYIGREVIFCKDMAFAVDGRYDAIPDGFKHTFLIRKPVKAFKSFHKVVNGYPGQTGEVSVKNGLPRSYAFKESYDLYNHICANYREKPIIVDADDLCRSPGSILKKYCAAVGLPFSESMLSWQPSDGISSRWHCAPSFRALNSTMGTYERALKSESFVSKDHNHNVEVISKDGLPKGVVECSEFSEPYYKKMYELRLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8H1</accession>
    <name>A0A8B7Y8H1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110978277</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110978277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088847.1">
        <property type="nucleotide sequence ID" value="XM_022233155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8H1"/>
    <dbReference type="GeneID" id="110978277"/>
    <dbReference type="KEGG" id="aplc:110978277"/>
    <dbReference type="OMA" id="MAIMKER"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034836890" evidence="3">
        <location>
            <begin position="23"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="4">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022088847.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="54099" checksum="4E1955E7AD73CE4B" modified="2022-01-19" version="1">MDSKRLWYILWTVLWIIEHRECHSIPTKTVPCKFEDNFCGYKQDPTDDFDWSMASQGVWETLQYKPNNYICAFRNATSLRPGSLARLVSPVYEVTTPSLLSLQFKHFKTEGDGSRLRISVHATTKIFGGRRDDQPFFRILGELKTELPWTTLEGRIDVFAPFQLVIEAEVGYFTRSIIAVDDIILTLNAYPVQPQTSVNDSAQQNALGGRQEGGANDALTLWPSLTSQDVGGRPSHTEGASQEGMAGSDDEGVSLCFVLALTSSSLLVIVLVIFMIVFLSLTRNKRRFRRFNFSHDYEEIKGKEAYNQTTSVSAMAIMKERPHPRLIYHNRHTSFSRIQSLSSCLSRLSMRDSLHSSIYAEITDADLDLDGDMSDPGIGNCTTMTTTCTGTWDICSSSESSSGSDNTLAGGSHITASSINKLYPSLSDEGSVSQNDSGWVENIIYERTSDISSFDSTGGRFGLSNAFKGFGCSKAAAGFKSRQRVHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9X0</accession>
    <name>A0A8B7Y9X0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA-processing protein UTP23 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110978559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089352.1">
        <property type="nucleotide sequence ID" value="XM_022233660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9X0"/>
    <dbReference type="GeneID" id="110978559"/>
    <dbReference type="KEGG" id="aplc:110978559"/>
    <dbReference type="OMA" id="CCMQALY"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09866">
        <property type="entry name" value="PIN_Fcf1-Utp23-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022089352.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="28855" checksum="7CA3979C7913DB5A" modified="2022-01-19" version="1">MKIKRYKHARRHLGFYKNVFNFREPHLVLVDGTFTCVALRHQTNIKDQLPKYLDGEVQLLTTKCAILETESLGKELYGAASILRRYRVLSCPHQEEPVAAADCIKGMIGDNNSHHYYIATQDPELSECTRGVPGTPLLYMNMNAIVLEKPSQTSQDHAVKLTQQRVATVDYQWDALKRLTGPQDGTRDERRPRRRRAKEPNPLSVKKKKKKATQKVLGEAGEGPQKASRRRRRRRSKLTAHVQEQSRSSEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBI1</accession>
    <name>A0A8B7YBI1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110978395</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110978395</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089055.1">
        <property type="nucleotide sequence ID" value="XM_022233363.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022089056.1">
        <property type="nucleotide sequence ID" value="XM_022233364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBI1"/>
    <dbReference type="GeneID" id="110978395"/>
    <dbReference type="KEGG" id="aplc:110978395"/>
    <dbReference type="OMA" id="KCAREER"/>
    <dbReference type="OrthoDB" id="10348807at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022089056.1"/>
        </source>
    </evidence>
    <sequence length="380" mass="43246" checksum="FCCF240CED238C18" modified="2022-01-19" version="1">MSAVAKSESLVHRDARLYCRRRHQKTMGKCAREERQSDALLARKLRHIQKSKAYREKELDREQEKCLTDLVAIFDRQCQIATTRLARRLKDALGETDIVELEDLWGKKTNDRQVAKGMRDDQAGTHRSLFCGKDRHSFARHSHVFTSADASPHKQFRNGYRLSNTGMSRMNDLSKDNRIRPDSPIPWQQKKDPMGREPIPNLNQHHLFKTHLGIHDSVQIPKANGGVAKRPTSSQPSAARPKTVPQIGENSLSANSRWDELASQVRCPQHGNNAPAYISRARSLRCLLRDCTDKTATPVFDAPEDVCFRRQYMACVMSRKLPVSGLRSGSFAQQDDVRKKMEARRKCMEELHMTSGQRAKSAPAGLVRICNNDLSAQWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDQ6</accession>
    <name>A0A8B7YDQ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c oxidase subunit 6C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110978810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6c family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089786.1">
        <property type="nucleotide sequence ID" value="XM_022234094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDQ6"/>
    <dbReference type="GeneID" id="110978810"/>
    <dbReference type="KEGG" id="aplc:110978810"/>
    <dbReference type="OMA" id="KNYDAMK"/>
    <dbReference type="OrthoDB" id="10051322at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22901">
        <property type="entry name" value="CcO_VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.93.10">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc/VIIs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051389">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034884">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc/VIIs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037169">
        <property type="entry name" value="Cytochrome_c_oxidase_VIc_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48416:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02937">
        <property type="entry name" value="COX6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81415">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022089786.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9397" checksum="8FD96DD4C9CA1F1B" modified="2022-01-19" version="1">MSALPRPQMRGLLNSHLKKHFAIGVVLAIAGAAGVKFFIYDWRKAKYAEFYRTYDVQKDFERMRELGVFQSVRPLSESGGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFH7</accession>
    <name>A0A8B7YFH7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Bifunctional arginine demethylase and lysyl-hydroxylase psr-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110980027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091989.1">
        <property type="nucleotide sequence ID" value="XM_022236297.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091990.1">
        <property type="nucleotide sequence ID" value="XM_022236298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFH7"/>
    <dbReference type="GeneID" id="110980027"/>
    <dbReference type="KEGG" id="aplc:110980027"/>
    <dbReference type="OMA" id="EPPRECH"/>
    <dbReference type="OrthoDB" id="10063099at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF19">
        <property type="entry name" value="CUPIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin-like" evidence="2">
        <location>
            <begin position="144"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022091990.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39888" checksum="9F1F26F208E3B70D" modified="2022-01-19" version="1">MDVRKRFTEIHQRLQELGTAGDQLTQLPSFKKLQTLSQSKSTSRIVRIVTLGFFWAVVLALVLAYIAIMLLVVGSNFLEDPRLEQVHRSLSQVWMERVMDANMDTETCLMAVPETLQDLFRPPVNCSICRDVEEIKKLSGLTQEEFERLYAYTARPVVVTDGMEQWTALQVLSFDFFKEIYSDKSPVLESNSPDCQFFPYRTNFDSLKEVLEMAPERANLSDGSAPWYIGWSNCDSTAANTLRQHYHRPYFLPPESESSKTDWIFMGSPGYGAHMHIDDVELPSWQAQVKGHKRWTLEPPPECYLECQTLEVEVHPGEIIVLDTNKWFHQTLIIGDEMSITIGSEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGK2</accession>
    <name>A0A8B7YGK2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">von Hippel-Lindau disease tumor suppressor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110980219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VHL family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092368.1">
        <property type="nucleotide sequence ID" value="XM_022236676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGK2"/>
    <dbReference type="GeneID" id="110980219"/>
    <dbReference type="KEGG" id="aplc:110980219"/>
    <dbReference type="OMA" id="WFFRDYY"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd05468">
        <property type="entry name" value="pVHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.780:FF:000001">
        <property type="entry name" value="von Hippel-Lindau disease tumor suppressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.10">
        <property type="entry name" value="von Hippel-Lindau disease tumour suppressor, alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.780">
        <property type="entry name" value="von Hippel-Lindau disease tumour suppressor, beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024048">
        <property type="entry name" value="VHL_alpha_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037139">
        <property type="entry name" value="VHL_alpha_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024053">
        <property type="entry name" value="VHL_beta_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037140">
        <property type="entry name" value="VHL_beta_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036208">
        <property type="entry name" value="VHL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022772">
        <property type="entry name" value="VHL_tumour_suppress_b/a_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01847">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17211">
        <property type="entry name" value="VHL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49468">
        <property type="entry name" value="VHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="von Hippel-Lindau disease tumour suppressor beta" evidence="2">
        <location>
            <begin position="61"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="von Hippel-Lindau disease tumour suppressor alpha" evidence="3">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022092368.1"/>
        </source>
    </evidence>
    <sequence length="200" mass="22671" checksum="332F84696E6FC8E5" modified="2022-01-19" version="1">MCGFKPQTSLSSKTSASVFIPRSAKRVVICFSMVLARLTNSETPFNFAMCGQQLKSAPGHRAKAYASFRNRSPRVVDILWLNWEGERVNYTKNGLKQGYKMDMNTYEGHPWIFRDHCSGDKLVFVAGTDGQSKEVFFPTPAGEERPHATQVNIQLPVYTLLERSLQVLRNLIRDKSDFDKLEIPAELKSQLANPVDTVIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGK6</accession>
    <name>A0A8B7YGK6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor Sox-10-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022092373.1">
        <property type="nucleotide sequence ID" value="XM_022236681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGK6"/>
    <dbReference type="GeneID" id="110980220"/>
    <dbReference type="KEGG" id="aplc:110980220"/>
    <dbReference type="OMA" id="FYNANAG"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002009">
        <property type="term" value="P:morphogenesis of an epithelium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22031">
        <property type="entry name" value="HMG-box_SoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000004">
        <property type="entry name" value="Transcription factor SOX-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022151">
        <property type="entry name" value="Sox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050917">
        <property type="entry name" value="SOX_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803:SF10">
        <property type="entry name" value="HMG BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45803">
        <property type="entry name" value="SOX100B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12444">
        <property type="entry name" value="Sox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="116"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022092373.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55230" checksum="C3978F28FB774F58" modified="2022-01-19" version="1">MSHNHSPQDTNYIGLAQYYYKPVSPTTTGSMLKMNVQITELERPLSRGSDGPVSPGCSESGSESDTATSGETPSSLDPRFPPSIRDAVSRVLQGYDWSLVPMPTRVAGNPNAKPHIKRPMNAFMVWAQAARKKLADQHPHLHNAELSKTLGRLWKLLSEPEKQPFIEEAERLRQQHKKDYPDYKYQPRRRNKNKPSKVPLTSEATVCKGSRSPGDAAREDGGERYAMHAQPQQTGPPTPPTTPKEEAERLSGQPPQKRMKYIQLKGERPHQQLPVDLVGVDIRDLSSDMMANMDGLINEDLDRYLVTSSAHGQHQQVPPPNSPKCSTYSMMNVCQNIGRSEQWLNRHGASQISVSSELKLEEAMLSPDHHYTASPTSTQVQPYDYSMQHQYAAEYPSMTGQSFDYPHQPSQAQLGYYTNNPNSPSAVSTLPATYQYPQQQTSPNHTSYGLLEGAQPVLSEARTWDTYQQNHNRSWEDQTVHSADKPCKSSPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIZ4</accession>
    <name>A0A8B7YIZ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase/reductase SDR family member 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110980647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093224.1">
        <property type="nucleotide sequence ID" value="XM_022237532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIZ4"/>
    <dbReference type="GeneID" id="110980647"/>
    <dbReference type="KEGG" id="aplc:110980647"/>
    <dbReference type="OMA" id="GHVFMVT"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052992">
        <property type="entry name" value="SDR_member_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44656">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44656:SF7">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022093224.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36263" checksum="2BA4DDDE7D0C9B12" modified="2022-01-19" version="1">MEDFNNPEFGYPGDECFRDGFMEASKEFDPAALDVDLTGKSFMVTGSNTGIGKNVTVELAKRGGRVHMLCLNADQATRTEIIKDSANENVHLHVLDLSQLRRVYKFAKKFAENWKTLDVLVNCAACVLPTRELTEDGFETNFAMNTMGVYILTKTLLPLLGQTPGSRVIMVSTQGVFTEKLSLDRLADLKKEKLDPFDGHKVYAQSKRQQLIMLTTWARTHSAIHFAGMHPGIVDTPLLRCYLPPAVYETAKRNGRFKTPAEGADTVVWLAASEGAVQQTSGQFYFDRKATSSHKWDFTRSTEAEEQQMMEKLEELAMGITSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJJ1</accession>
    <name>A0A8B7YJJ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Multidrug resistance-associated protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110980770</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093419.1">
        <property type="nucleotide sequence ID" value="XM_022237727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJJ1"/>
    <dbReference type="GeneID" id="110980770"/>
    <dbReference type="KEGG" id="aplc:110980770"/>
    <dbReference type="OMA" id="HECCINL"/>
    <dbReference type="OrthoDB" id="10056452at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="249"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="181"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022093419.1"/>
        </source>
    </evidence>
    <sequence length="369" mass="41386" checksum="066C1844C5481B54" modified="2022-01-19" version="1">MALLGELPTVSGVNTLIGRIGYTAQQPWIVSGSLRQNILFGSEYESAKYKRVIKQCALTRDIELLSHGDKTLVGERGVTLSGGQRARVSLARALYSDADVYLLDDPLSAVDPAVGRHLFERCILHQMRDKVRILVTHQLQFLDKADKILILKQGSVAGYGTYQELQEEGVDFAALLKKKSEDSDDTGDKEQVLEGRKRERNTSMRSSALFRPNQEQAETPVDITPEEMAVGTIEWMVYIRFFRAAAGFLFLLVWAIIVVGAEAALTFTDLWLATWAYEEEKDLAARNQNFQNASKYDNQSHYVRIYAMLCGGSTLLLLVRSFLFFHLFVTASRALHNQMFASIIRAPMQFFDTNPVGKTSRLCATALVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJT3</accession>
    <name>A0A8B7YJT3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">PACRG-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6" type="primary">LOC110979941</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091825.1">
        <property type="nucleotide sequence ID" value="XM_022236133.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091826.1">
        <property type="nucleotide sequence ID" value="XM_022236134.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091827.1">
        <property type="nucleotide sequence ID" value="XM_022236135.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091828.1">
        <property type="nucleotide sequence ID" value="XM_022236136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJT3"/>
    <dbReference type="GeneID" id="110979941"/>
    <dbReference type="KEGG" id="aplc:110979941"/>
    <dbReference type="CTD" id="133015"/>
    <dbReference type="OMA" id="HKLQWEC"/>
    <dbReference type="OrthoDB" id="10258089at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207:SF1">
        <property type="entry name" value="PACRG-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PARKIN COREGULATED GENE PROTEIN PARK2 COREGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022091827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022091828.1"/>
        </source>
    </evidence>
    <sequence length="233" mass="25024" checksum="12C62045D55F56AE" modified="2022-01-19" version="1">MASRAQPRTPGKSSSSQLRGGAPTPGGIGHGGGESPASRPMKKPSDRLNPKTIDPFKESKNPKSAFASVYARGGIPCRLVHGSVKHKLQWDCNPCDLPFDPLLITLAEGLQEFKHPYQFVAQQGFKELLQVSDASTKATAVLSRIILPLRNALGSSNDSVFEGAVDALVHLSIAVGPQLNPYLKSVLSYLSKKLMDKNCKDSITTALQQIEQACGKESQAIIKSKIPTYSSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YL18</accession>
    <name>A0A8B7YL18_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="18">1.3.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110980598</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = testosterone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50820"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:17347"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.22"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:50822"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5alpha-pregnane-3,20-dione + NADP(+) = progesterone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17026"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.22"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:21954"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 3-oxo-5alpha-steroid + NADP(+) = a 3-oxo-Delta(4)-steroid + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54384"/>
            <dbReference type="ChEBI" id="CHEBI:13601"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:47909"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>androst-4-ene-3,17-dione + NADPH + H(+) = 5alpha-androstan-3,17-dione + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:50816"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16422"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:50817"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.22" evidence="18"/>
    <dbReference type="RefSeq" id="XP_022093130.1">
        <property type="nucleotide sequence ID" value="XM_022237438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YL18"/>
    <dbReference type="GeneID" id="110980598"/>
    <dbReference type="KEGG" id="aplc:110980598"/>
    <dbReference type="CTD" id="6715"/>
    <dbReference type="OMA" id="PHYALEW"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047751">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006702">
        <property type="term" value="P:androgen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000002">
        <property type="entry name" value="Steroid 5 alpha-reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016636">
        <property type="entry name" value="3-oxo-5-alpha-steroid_4-DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF57">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015596">
        <property type="entry name" value="5_alpha-SR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="19">
        <location>
            <begin position="126"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR015596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022093130.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30947" checksum="2C442D02A6C11021" modified="2022-01-19" version="1">MSTPAGDPVSLPLTQTLTDMLGMKEEEFLDKVAYCFIFLGAFVSVILQFVGAPYGRYVDSRFGCFIPGKVAWFVQEIPSFLLPTILLIASGGEQGFVNNVLISLMIFHYFQRTFVFTFLIRGGKPTTLLAFLLAFFFCVTNGYLQGQYLTHYAVYPQSWSRDPRFIIGVFLFFSGMAINIHSDSILRNLRKPGETGYKIPHGGMFEYVSGANFFGEAVEWSGFAIACWSLPGLAFAIFTACNIGPRAYRHHWYYKQKFEDYPKSRKAFIPFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLI9</accession>
    <name>A0A8B7YLI9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AH receptor-interacting protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110980708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022093310.1">
        <property type="nucleotide sequence ID" value="XM_022237618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLI9"/>
    <dbReference type="GeneID" id="110980708"/>
    <dbReference type="KEGG" id="aplc:110980708"/>
    <dbReference type="OMA" id="QQHERNV"/>
    <dbReference type="OrthoDB" id="5829758at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000052">
        <property type="entry name" value="Aryl-hydrocarbon-interacting protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056277">
        <property type="entry name" value="PPIase_AIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF0">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23322">
        <property type="entry name" value="PPIase_AIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="AIP/AIPL N-terminal FKBP-type PPIase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="264"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022093310.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="38271" checksum="4A6ABBBFEDDC7A7E" modified="2022-01-19" version="1">MERALGVELGSDINKQLIHPGKGELSDYRDGTKIYFYYKVTKCNDERTVLDDNRLQKKPFELITGKQFKLDVWEKCLKTMRDGEVAEFTVAPSELTTFAPVMKKLRDIAKGTVATPEGGHCCGMAQMNQSGLGYPDLDEFLKQPEPLRFTFEVVRIEEEGQYRKESWAMSHAEKRAALPLLREEGNRLYNAKQYAAAAQKYAEALGCLENLLLHEQPNSPEWLATDDMRIPFLLNFAQCKLMLQDYYQVIEHTTTVLTKEETNVKALYRRAKAYAACWDFSQSRKDFKMALELDPSLGAAIRKEFRLLEEAEKKKDEEDKVKMKAVFERFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLP9</accession>
    <name>A0A8B7YLP9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110980737</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the apolipoprotein L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093370.1">
        <property type="nucleotide sequence ID" value="XM_022237678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLP9"/>
    <dbReference type="GeneID" id="110980737"/>
    <dbReference type="KEGG" id="aplc:110980737"/>
    <dbReference type="OMA" id="NELTTHH"/>
    <dbReference type="OrthoDB" id="5976087at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008405">
        <property type="entry name" value="ApoL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096">
        <property type="entry name" value="APOLIPOPROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096:SF28">
        <property type="entry name" value="APOLIPOPROTEIN L, 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05461">
        <property type="entry name" value="ApoL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093370.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="29118" checksum="BDD3EC7140ECF272" modified="2022-01-19" version="1">MNYHGQRDMDLAVQLARDIGALEDASMNYVRSRRATIQLLRDLADYLQKHHHRAKIAKVVGGSVGVVASGLVIGGFVASFFTFGASLLVAGVGAGVGAAGGLTTVGGFLTEIITQKLTTTSAKKILEHDKIACDNLKAALERVESTWRSLRDAGRVVVGLASGGRQIFNVVDSIYDLVRVGAVAFQAGEVASQTAFKAASTVGRGMAVVGVAFSVIAIPLDLHTVITSSIAIHNRTVPEVARVILEKAKELAENCPSEEEMHAHVTRIRGALQHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLS7</accession>
    <name>A0A8B7YLS7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calmodulin-lysine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.60" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022093602.1">
        <property type="nucleotide sequence ID" value="XM_022237910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLS7"/>
    <dbReference type="GeneID" id="110980872"/>
    <dbReference type="KEGG" id="aplc:110980872"/>
    <dbReference type="CTD" id="79823"/>
    <dbReference type="OMA" id="CFLGIWP"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018025">
        <property type="term" value="F:calmodulin-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025800">
        <property type="entry name" value="CaM-Lys-N-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539:SF3">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022093602.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32338" checksum="A9C443315DCE782F" modified="2022-01-19" version="1">MTMFPSPGIDPVSLFTLEECTESNQVNSASVRRFSTFGLLSTNHLPHKLSQGAHRWAEYTCPHYREFSVSIRHLSNNFSASELVGFNNTGNVCVWPAEEVLTFHCLKNAESFKNQRICELGGGMTCLAGIAVAVCTDAAEVLLTDGNENSVQNVQEILAENRSKICQTSIAVRELKWNKRQTFEDLNGHFDHVISADCLFFDRFRQDLVDTIDVLLKPKGVATIFAPHRGKTLEDFCQLARPRFTVEVDCKYDQLVWQKHQEMLTQGKEVYDEDIHYPVMITLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNT5</accession>
    <name>A0A8B7YNT5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110980592</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110980592</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093115.1">
        <property type="nucleotide sequence ID" value="XM_022237423.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093116.1">
        <property type="nucleotide sequence ID" value="XM_022237424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNT5"/>
    <dbReference type="GeneID" id="110980592"/>
    <dbReference type="KEGG" id="aplc:110980592"/>
    <dbReference type="OMA" id="TASVIHY"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000025">
        <property type="entry name" value="Lysine-specific demethylase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF53">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665608" evidence="1">
        <location>
            <begin position="25"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="145"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093116.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="50339" checksum="6D1A878B182CE382" modified="2022-01-19" version="1">MDLRSPDALVLLLLLLVSLQDAISDVTFPKDQRAIEFPPQIPKPRPGSAVPTGHLRPFGYQRKSDGPVPEYNVFLHPVEFYQNHVSTRKPVVFRQSMTDAPALQKWTDQYLQEKYGELDVLVEVKRENREIRPRRMKLAEFLKRYLTDDVYIVSLIPLEMAHEVKVPDSLLCGTFKRRLLETNLWMSSGGTASVIHYDADHNIHCLLAGRKDFIMIDPKYSKELEITEEHHMTGSGYSKLDVDMINLFEHQDVGKVPWRWSTLKPGDCIYIPAGYLHQVRSYSRSISATILFASEPTFDQSDCENATFEYTDLSQVRVMWTYKKGDKVIEIGYMDTENIRNDMISLLKETDKLSAHRFGHYFMGMSGMEEEEVATEDEDIPIEAYEIFATFDTERRGYLTRKQIEEIDVERLKNFARVLDQPSGPVVIEMEHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YP91</accession>
    <name>A0A8B7YP91_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box only protein 21-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093266.1">
        <property type="nucleotide sequence ID" value="XM_022237574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YP91"/>
    <dbReference type="GeneID" id="110980679"/>
    <dbReference type="KEGG" id="aplc:110980679"/>
    <dbReference type="OMA" id="KQPFYNV"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02097">
        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF21">
        <property type="entry name" value="F-BOX ONLY PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemimethylated DNA-binding" evidence="1">
        <location>
            <begin position="475"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093266.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="69365" checksum="C6AFB2230F89D784" modified="2022-01-19" version="1">MSAESADINFFDFLPTEIVTLVLTQPSLYFRDVVNFGTTCKRYLGIISDNELWKVKLLYRFPCLQQVADSMKPTSAWLDHCRQLHKLPETVKSLVAGLSAKCFLRDEVTYSHFRPLKELYYRSDLCQALMDEVLMTLVNDEDKYKDLTLRYYAEKTLRYLCRTKLRQEWQALLALPIEQQSLLEGAILFERWHNFFSPSPKDSIRQEVSQIAERARRKLKMDHPSYHSNIGGAVEMTPEQCYEVFDAVNEVMFKEMNFQGNSEDFYNESNSYMSLVLTTKLAIPITLCILYEAVVRKLGITLRPVNFPGHFVLCWNYSSDGFKESDTNLFIDAFKKGRMMTSAEVLMSSLHIGMHGYRPDYLQACQPRAVFQRMAANVMHLRQDIGSNFDGIELQALLNPEDCETVMDCIKYYVGRNINYAESLAMLQEIRPQNNQEQRNVTVFTEMIQRTMEKYGKDDAEPTMPSAKQREDNKEVIYAVGMVMKHRRYNYSCVIYGWDPVCKLSRDWQRHMGVHHLPKQEKQPFYNVLVEDCSNRYAAQENLDFIDVPVTISHPEVGKYFQNFTGKCYLPNDELACQYPNDMAVTTQKTTEIYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQV0</accession>
    <name>A0A8B7YQV0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="12">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC110981916</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5,6-dihydrouridine(20a) in tRNA + NAD(+) = uridine(20a) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53348"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:53350"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(20a) in tRNA + NADP(+) = uridine(20a) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53344"/>
            <dbReference type="Rhea" id="RHEA-COMP:13535"/>
            <dbReference type="Rhea" id="RHEA-COMP:13536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53346"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5,6-dihydrouridine(20b) in tRNA + NAD(+) = uridine(20b) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53352"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:53354"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5,6-dihydrouridine(20b) in tRNA + NADP(+) = uridine(20b) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53356"/>
            <dbReference type="Rhea" id="RHEA-COMP:13537"/>
            <dbReference type="Rhea" id="RHEA-COMP:13538"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.90"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:53358"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 14">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Dus family. Dus4 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022095653.1">
        <property type="nucleotide sequence ID" value="XM_022239961.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095654.1">
        <property type="nucleotide sequence ID" value="XM_022239962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQV0"/>
    <dbReference type="GeneID" id="110981916"/>
    <dbReference type="KEGG" id="aplc:110981916"/>
    <dbReference type="CTD" id="11062"/>
    <dbReference type="OMA" id="QRPHHDI"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102266">
        <property type="term" value="F:tRNA-dihydrouridine20a synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000100">
        <property type="entry name" value="tRNA-dihydrouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF31">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20A_20B) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 12 14" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="15">
        <location>
            <begin position="31"/>
            <end position="301"/>
        </location>
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    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="116"/>
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        <location>
            <begin position="33"/>
            <end position="35"/>
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        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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        <location>
            <position position="87"/>
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        <ligand>
            <name>FMN</name>
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        </ligand>
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        <location>
            <position position="186"/>
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        <ligand>
            <name>FMN</name>
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        </ligand>
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    <feature type="binding site" evidence="14">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>FMN</name>
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        </ligand>
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            <dbReference type="ARBA" id="ARBA00001917"/>
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            <dbReference type="ARBA" id="ARBA00002468"/>
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            <dbReference type="ARBA" id="ARBA00022630"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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            <dbReference type="ARBA" id="ARBA00050434"/>
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            <dbReference type="ARBA" id="ARBA00051779"/>
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            <dbReference type="ARBA" id="ARBA00052996"/>
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            <dbReference type="ARBA" id="ARBA00060741"/>
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            <dbReference type="PIRSR" id="PIRSR006621-2"/>
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            <dbReference type="Pfam" id="PF01207"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022095653.1"/>
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    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022095654.1"/>
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    </evidence>
    <sequence length="340" mass="38119" checksum="F3EC12F9F762EE92" modified="2022-01-19" version="1">MMAHEEQSSDKAIQHQSLMDLLDKKKPLKICAPMVRYSKLAFRTLVRRYGCDLTFTPMIMSNSFVRSMKARDNEFTTNKGDRPLIVQFAANNGKDLADAAELIAPYADGVDLNCGCPQRWAMCDGYGAHLIKNPELIRDMVRQTKARVGRADFTTSIKIRIHPDLRDTVDLCQKAETAGVSWIAVHGRTPRERAEPANHDAIKLIKESVGVPVIANGDIRSLEDMQRVCDHTNVDGVMAARGILENPAMFAGYNLTPTHCVQQWLDISLSLGTPFQCFHHHLIYMMEKMVMRADKRVFNVLTSTAAVVDYLEENYGIHPSTEVSIEDTRGSSAPPLDRIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRY0</accession>
    <name>A0A8B7YRY0_ACAPL</name>
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        <submittedName>
            <fullName evidence="6">Methyltransferase DDB_G0268948</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110982136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096038.1">
        <property type="nucleotide sequence ID" value="XM_022240346.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7YRY0"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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    </dbReference>
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        <property type="entry name" value="Diverse_substrate_MTase"/>
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        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="48"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022096038.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="31990" checksum="FB89ADF65FED8A48" modified="2022-01-19" version="1">MTTETSRFRKEDHAAIYLRSHPDWPPEIIQRSLSFLREKTAEPFKLAVDVGCGSGQNTRPLAPYFEKVIGVDVSEAQIKVAQSLKNPPNVEFRTGSAEDIAVPDRSVDLITCAESVHWFDVDAFFREMDRVLKPNGCIAIYSYNNILPWVEGVAVKNEQLKDVVMQFNCVTLRPYASQCSQHLRNMLADIHIPYDETIRDESFYLQYDTSMESYMSYIRSWSTYQAYLEKNPSGPDILKEVQERLMQILGLDYSTGNAKVPTKTPIVLLLGRKPHKETSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTD3</accession>
    <name>A0A8B7YTD3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110981975</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095740.1">
        <property type="nucleotide sequence ID" value="XM_022240048.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981975"/>
    <dbReference type="KEGG" id="aplc:110981975"/>
    <dbReference type="OMA" id="WWGEDPS"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="12">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="13">
        <location>
            <begin position="1458"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="11">
        <location>
            <begin position="1826"/>
            <end position="2247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="411"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="548"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="779"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="900"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1563"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2085"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="548"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="633"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="834"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="870"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1572"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1603"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1623"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1644"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022095740.1"/>
        </source>
    </evidence>
    <sequence length="2258" mass="245133" checksum="DB3D3416BADD42FD" modified="2022-01-19" version="1">MTAANSAANGASLEDCHTNLFALTDLSGIKWRKFSYDCPQEPLGPLEDPVLVSYSRCIAANILSVWRRVPFMNTDLLLSLDVPMKPDPIWTKELWIYWYGDDPNLEEKISPDLKEVDEGTWDNGLSYECRTLLFKSLHNLIERCLLSHNYVHLGKWFVRPYDSLPASPDSFNDHLSFAFSFFLHGESTVCANVEVALHQPVCRLSLDHLALAQGSATGFQVILSPYGLSGVLTGHSYKASHSASRRILNEWHHFYPIKFQGDEESRDTPLDEDSLEDGLPAVVDVLVAGVRMLYPTAYVLVPQSEEMAHVPIAPMPGTTYLPPPPVQNAGARIHGITAAAMSSISLTPPTSPPDQPLPGEAKITMVSSGVYASAPDPALFPAESDLLSPQMLAGRMAGRLWRELTVPAPEVPSSQTVAAPSVDSSVLPSEDGSTAAATVPAAETRSTATNTTVTWDFNDPSTRANCSCSRQKSLKQKGGLAFSKSHPSSHMSSKHSKSDSKQERQQRNQRPVTPFHHRTITCEDILALEQEAVNQRLAAQQSALPSLPAGAATGQAQPQPLQQQQQDSKLTQGKFTQPSPAAFRPMGPVDSVLTESPPSVVPSPLLPPPTGATTSANERTMPALSPYPPPRSGSDSGTPTATSAPAIFARSDAIPVNQDHPDGLPVPPMMGTAQMMDSIPRGMDAHLMAEHQKEEREEDPLWQCFKLPSGLDCKRPLLPAQCYELDDADGGGWDALYEMDNNIEVFSQPLKKLKPERPLLTNQDLLSGNFSVDQLEYKPAQRAASPEPVDPYEFMEHDPSPTSRVISYRSRGKDVKGKPKGLAPRRNSNRKERKKLEEEAVRRAEEEKMKQEQMAQEQMQSNSVDDKGPMSNQSVGRLDSSSLMQVNDLKVTYEDLEQLFQPSDDDDDGGPFEDKSLGPPSEEAKPLPGNTGPVGGAYNSATELAVMFPTPPSLEQQNSAFSPLNQPCQEYLNHGSVAGLTQIEQSSLGDISEVEVDDTMGSPKPDSIEDWSYVYKTPMIERFVGASMYAPLKSLPSSKLPPLRIPENCIYKPSWQIPLSPKPEFIPTTKESATSGGGQLMNSPASAAVPVGVYPPGSQGPRSVANTDIAPSPASEASSYIKNLNSLESASLGSNIPEAHSLTVNLVLSDSQLNLFKDRNFDSCVICACNMTIRGSEAAAAPGYDTLGPCSCGFSAVMNRRYGTGSGLFAEDESEITGQYGDVALWAYHRDNPMLAADFARKDPLAQEGGLTRLYTRDGVPVGTDILRTSNALLRLIQDQCNTPYSTLCRLNCIAKRKNINSSGQLARSQLEIEDGCEVCFAALEQGRQVAENSSNAKLDDTLLKNSCLHSWPYTPGLYRSQLSSQDIVRTLSSLQPLLQDAIQKKRTTRLWERPYTVQGPLTWQVFFNLAAKGSSESPEPLPIPPLLVGYDKDWLSSSPYALHNWEKLLLEPYSTARDIAYVALVPDNDFILQCAKSFFREVTAVYESCRLGRHAPIAKTQRDGIFRIGSKYASKVAEEPVDDWFSEIAHLPDSCKLKLYAQVCKAYVGPFLSGDPPDHTLFTTSRHDRSSSSSSSSALSNLSNVPGSTSVVPGGTHHLAGAGQGGGSGVAGMGSSQGSGGVSSSMSQGMSSGDGLGSVAGAGSQQGNMNMPAPSTTGPAGTGSQQDASSCSDKSDSKENETGISIPEDSDCEKPPAPAVVVYIVNPFGLEEEDYGGGGGVEQSVSSLALLKSFAEVQNHVQGELRRNLILQIIPLRQILQVANSDMSSRLLSQIKCHAFSVFSQSRRHLQPSVAGQSLTGFGPAAELDRILKSNKGPKPQYRLYSPPYILTPLKDKQTELGESFGELRQACCELFCGYCLSHDQRLLLVACTDSKGEMMETQVINIDVPNRKRRKKVCVRNIALIKLWDFLMGVMSKTAVPWRLVVGRFGRLGQGELRDWSALLSRRSLTTQSRTLKDMCNMCNVTGNNDYPCILSACLVSMEPEPGLRIMADSVAADKCSKNAQRDQPSCQLHTPDDATCTHIHVFPTSATKQVASGPYQAEPMMDLSFTNPTDNVLPADDDLLFITEGLGNQDLAQILGLGSPTNMGSPVPSPGGGGHSPGPSSPSGQQMNMAVNSENMNKNTNQQLLPTEPEESLLQQPLAMGFFVSTAKTGPLPDWFWSSCPEAENNCPVFLKAALHLHNASVQQMSDDILQTKHNHPLDSNLTTDVLRYVLESYNSLSWLTVDPASGDRRSCLPIHLVVLMQLYNTIAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTG8</accession>
    <name>A0A8B7YTG8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Histamine H2 receptor-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17" type="primary">LOC110981989</name>
    </gene>
    <organism evidence="12 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095770.1">
        <property type="nucleotide sequence ID" value="XM_022240078.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095772.1">
        <property type="nucleotide sequence ID" value="XM_022240080.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095773.1">
        <property type="nucleotide sequence ID" value="XM_022240081.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095774.1">
        <property type="nucleotide sequence ID" value="XM_022240082.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095775.1">
        <property type="nucleotide sequence ID" value="XM_022240083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTG8"/>
    <dbReference type="GeneID" id="110981989"/>
    <dbReference type="KEGG" id="aplc:110981989"/>
    <dbReference type="OrthoDB" id="10034726at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="76"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="434"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022095770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022095772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022095773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022095774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022095775.1"/>
        </source>
    </evidence>
    <sequence length="597" mass="65782" checksum="0DB5DF6C85193975" modified="2022-01-19" version="1">MSQADTETVFIMAVTESAATDATVIPNISDSLTWDSASTNNLTTPAPGLQPPYWDLPVVITLASVLSIVMVISIIGNSLIILTIIFFKGMRSKTNMFITNLACADLGVSVLCMPFSLATVIQGDWTFGPVLCNANAFFEALFLVASTHGLMAIALHKFSSLVLPLKRIINLRRAIAMVTFAWFIGLTCAIGPLVGLTKNVYKPGTSQCGPKYPEKLSEKIIGLYVPLVGIIIPLTCLILVYGVIFNTIRKYSRRLRSHTSMTEDKIFHQQKRITITLFIVFVAFFICWTPYFVYSTLGFSLGFQKVPTILNVAAYWSGYTNSALNPIIYAWRAKSYRKAFRKIFCCNVKGSLLSDTGTANNGDSSSVALRLSRARPSILTPELVCRKSSCYQQVWGQQGVMSAQSKKGEKGSPSPCVEVHEFASPALLRRSRILQGGYPGSQPGSKSSSLNSILKPSPVPRRDHGSSTNRPTAILVKDVKTNHGDIWLRGLVGVNGHTGLQGTSSDDDEDDVFLPDRALRRSQSETDKEWLERKHFEVTPRAKNHFPYRSDPGKRGLKKSLSIGLKQQEPPTQQIPNINWEPDAKARRALLGRSTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTQ3</accession>
    <name>A0A8B7YTQ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Roundabout homolog 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110982036</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095860.1">
        <property type="nucleotide sequence ID" value="XM_022240168.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982036"/>
    <dbReference type="KEGG" id="aplc:110982036"/>
    <dbReference type="OrthoDB" id="428111at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000600">
        <property type="entry name" value="Contactin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000026">
        <property type="entry name" value="roundabout homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000008">
        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF60">
        <property type="entry name" value="ROUNDABOUT HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="985"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="51"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="151"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="243"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="333"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="433"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="544"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="660"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="774"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="869"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1054"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1222"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1542"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1230"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1349"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1388"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1543"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1560"/>
            <end position="1570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022095860.1"/>
        </source>
    </evidence>
    <sequence length="1648" mass="178375" checksum="39C7BC659A3D819A" modified="2022-01-19" version="1">MKACLQSGLDTNTAKTNRLSLFGLVFLLWNCSMIASVIGAPGGNRREDYPPRITEHPQSVIVPRGEPTTLRCRADGRPDPTITWLKDGERLDLLSGDGHRSMLNPGELFFLRVIHSKGNNADVGTYQCVATNYLGEAVSNNATLEVTYIKDDFRREPVPTEVEGGEPVVLECQPPRGYPEPTVTWSKDDEDVIVDGDRVKVLQDGNLMISQSRASDAGSYVCTASNQMGSRSTDPVYLTVKAPPLLVHPVQDIMVGPGTTVLIGCDVIGDPIPVVTWSKQSGELPPGRYSILEDNSLRIRQVTQEDEGVYVCEAVNSNGRVQDDMMLTVSVIPTFTQAPMDRTVEIHHTASFQCQATGSPTPAIVWKKEGSQEELLFVDMQSGRLQVTSDGELHVTDVREEDEGYYVCTAHSGSSVIEARAFLRVIASVSQPPPIINYGPSNQTLIVGTVALLTCETAGNPAPSVRWTKNGAPLHASDTRFTVLDTGRLQISGLFLEDSGMYSCIATNSSGQTSWRAYLRVIERSEASDIPVLQAPNIHELPASPGQPTASNITRTSLTLSWLPPSRTSPPLSPITHYRLEYFSHEVASEWQIVPAPCMGQTCLVQQLRPGTTYLFLVRAVNDRGIGPPGPISQPITTRDVLSAIPSEQSTLIEEWLQKARVDITNAMVLSPTAVKVLWEVRQHHEFIEGYHLKYFAASDTNGFTMQTVLGSTNKIITGLTPNTGYTITVQPFNSGLNGPESDPVDVDTHSQGDELPESLIDNPVLQGKLNTCGTTIVSIEPIGSTSLKITWRVSKNEPYIDGYHIKYSVQDSHDMIIQTVTGSNIKLLTDLTPWTWYRVTIQPFNGLYLGPESPHQDARTQSGVPTSAPRNVQVVNNGTAAILVTWNPPLASTVQGVIAGYNVYCLAYTAALHKNVTTEAGQLSVRVTRLLVGEVYKLSVAAFTTAGEGPSSSVIRVQITQGGGDGLDWEDDGDDSGSIVTQPWFIASLAVFFLLILLCIIVFVWRRRKQYKLAGTISKGPISRDNAAAAHNMGIGSSGQFVSSNHSSVQSSLQRSQGWVNPSQRPLPSTVGLLSDTSDHHGNRPCVPIGSASSSLNRAEYLQPNNTAYWLLEAYDPESGTLRQYDTQQPGSNGRRCHQCPPSHSCYGSGGPVYAVVDNADDDDEDAVYAGDVVHGPHSALTLPMPRCPEHTKEKLTVSNSLPPHVTEPYASTTLIMPTNVSEMRPPCSHSGSSEQSAGSSQSAARKDHRGRHNPADSSSGGSTQQGDRVSRKKRHRGGSNQPARNWTELLPPPPEQPPTDIDSPTEITCPAPTCSHAPTNLHMEQAKYCQDMERSKKKAPPPPLRQCCSSPPVSASDRQQTVPSHRQPPTNSLPKTLNSNRSSTPVDRRQQPHSEVSDRPSDPDHSQRGVPYLASKRLFEDPRHEQLGKELLEFNDDMSQSEILSDNEDLTGMLPTSTSHVDQGLHHNPVGYMPSGSQIPHLSQTEDDTDCAGSCTDAMLGSWSSMNGSSSSGRHSSVSESSEGSFFTDADFASAVAAAAQNSGMQVVGSTVTDPRTGKKHSRHGGRHGHTDQARQAAHAGSKLPSHINLSTFKPMTAGGIEMNGTSQSSPAKTSQSHPLVLQDTNGAGLTVTANPLAFAMEDSQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTR8</accession>
    <name>A0A8B7YTR8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="3 13">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 24" type="primary">LOC110982046</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="3 13"/>
    <dbReference type="RefSeq" id="XP_022095874.1">
        <property type="nucleotide sequence ID" value="XM_022240182.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095875.1">
        <property type="nucleotide sequence ID" value="XM_022240183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTR8"/>
    <dbReference type="GeneID" id="110982046"/>
    <dbReference type="KEGG" id="aplc:110982046"/>
    <dbReference type="OMA" id="CDLNEPP"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000096">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000072">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000064">
        <property type="entry name" value="cGMP-dependent protein kinase, isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002374">
        <property type="entry name" value="cGMP_dep_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF147">
        <property type="entry name" value="CGMP-DEPENDENT SERINE_THREONIN PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000559">
        <property type="entry name" value="cGMP-dep_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00104">
        <property type="entry name" value="CGMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0140">cGMP</keyword>
    <keyword evidence="10 13" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="196"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="314"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="465"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="724"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="739"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="471"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000559-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022095874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022095875.1"/>
        </source>
    </evidence>
    <sequence length="774" mass="86471" checksum="D7DE7006D57BB32A" modified="2022-01-19" version="1">MPPPSEKSPLVGKNPLGSGNGAQSNRAVGAGRRTMGNGAGTQSRSPGTANRSENGKGKEDSELLQLKAKVAQLALDIMDRDAELGMVRKEIKSCNELLSEREEEIGKLREEVHKLRSVLQQRTLQDVVQPDVLSTIHEERGMAGANKDRNKKQGVSGESGIQDNVTSADDNYTLQRYEKTSSSKELIKSAILDNDFTKNFDATQVKEIVECMYPMEFGAGQLVIREGDAGAHFYVAADGNLEVSKSGKKLGKMGRGKVFGELAILYNCTRTASVIAVTDAKIWAIDRTAFQVIMMKTAMQRHDEHLQFLKSVVILQSLSASNLFKLAESLEVDFFVEGEYIVREGTRGDTFYIISKGSVTITQSLTGLDEPQEVRQLGRGDYFGEKALLSEDVRTANVIAGKGGCQVLVIDRIVFNELIGNLQELQNKDYGDQERGATRSSNSSEPDTQRQSLRDKFSNIELDDLDIIATLGIGGFGRVELVGLAGDKKTFALKCLKKYHIVETRQQEHIYSEKKIMMNANCLFIAKLYKTFKDSKYVYMLMEVCLGGELWTILRDRGSFDDHTARFFIACVVEAFSYLHSKGIVYRDLKPENLLLDSNGIVKLVDFGFAKYIGFGRKTWTFCGTPEYVAPEIILNKGHDYAADYWSLGILIFELLTGNPPFTSADPMKTYNIILKGIDIVEFPRKIPRHAATLIKKLCRDNPAERIGYQKNGILDIKKHKWFQGFDWEGLKRQKVDPPIIPQVRGPEDASNFDSYSKDLEIPPDELSGWDENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YU37</accession>
    <name>A0A8B7YU37_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110982592 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096814.1">
        <property type="nucleotide sequence ID" value="XM_022241122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YU37"/>
    <dbReference type="GeneID" id="110982592"/>
    <dbReference type="KEGG" id="aplc:110982592"/>
    <dbReference type="OMA" id="THERWAK"/>
    <dbReference type="OrthoDB" id="9982425at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042342">
        <property type="entry name" value="TTC22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253:SF1">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="526"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096814.1"/>
        </source>
    </evidence>
    <sequence length="677" mass="77922" checksum="6CDCD9CD6F229FF9" modified="2022-01-19" version="1">MHVQLCVVLLSCQRLLFDPFPAQHSGLLSRKMFSSDGRGWGYDEDEEVIGAMGCHLTWMDLHGIDKRTLTLEKKFLEGRDADFETRPSLWLSLTNLLGFVYYSLGLTEDAEAKFDEVVAKDASNITALGNLTVIYRRQSRMKQYRAGLETLRGLLTKRDPVHVARSYADRAFALRHFQEHRRCFTYLSHISKAVQCAEGALTVPERAEWMYDYGLALHRRYMQMLHSGAVQDEQDTEQGMREVVECFHHVTRVEGVGLDLQALSWVFIGALLSVCPGKTLADALDDDTCNFTATDCFEKALELQPDNAEVLARTGAQFTDLKMYDRAKELLDRSLHKKESWSALRSRASLSMKMYEDQDQRETFSDKDVDELLQVALSDFTRAAELKETHADFSDLGYVYFLLKQPYKALRYFSNAVKSEQDDEFDLSVTHERWATCLASLGEEEGAAMQSTQKEKARRKMRQQATVLEDAWRHRHGVNCQGFECDLARFDYSSQDRPGYVNVLGDDHPQPSADAAHYVSRNQGAFKYDFFISFSHIDNKWSVALVRRLETEFNLKGNIRYRDYQLGAAIAENIAESVSNSFRTLIIMTPDSHRDQWCRYEVQRAHMTNLQRPCVVPIMLRPCLVPRELEHLTFIRCYKGQFRVEDWHRLGQSLCQFIPEAQPNWPARSRDDNIGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YU42</accession>
    <name>A0A8B7YU42_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110982593</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096819.1">
        <property type="nucleotide sequence ID" value="XM_022241127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YU42"/>
    <dbReference type="GeneID" id="110982593"/>
    <dbReference type="KEGG" id="aplc:110982593"/>
    <dbReference type="OMA" id="QRAEWFF"/>
    <dbReference type="OrthoDB" id="9976543at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042342">
        <property type="entry name" value="TTC22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16253:SF1">
        <property type="entry name" value="TIR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="388"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="524"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096819.1"/>
        </source>
    </evidence>
    <sequence length="660" mass="77832" checksum="DEDD92784166435D" modified="2022-01-19" version="1">MGSLNYCDGYQLIGWRDYYYIMASATRASDMIESFGCHLSWTELRPVVADRQALSREEGILVKEQWDFDDRPTYYTAIRNLQGFIAYHLNKHDQALAFFQDVLDKDENNINGLGNMAVLHEKLYEIDEVKRYREKLQSVLERPSYEERARAYADKAHAIRYFEQFKRCFRYMRFIERAATIGRKCDGPQRAEWFFDYALALYRRDVQMLYLRKLAREADCAPEHSECYSDERIWEGFLKACKFFLEVARTSTSRDYQALSWVFLGILVNHDPENRSIAMAFPDEPEIQHLTAADCFERGVGMHPEHDIVTRRVGSEYVKLGRFAEAKFWLDKSLNILPSQFAYRHRGSMFLRMYEAADEEEKRTEDAKQWLREAVKDFNKALEMKEIHADYSDLGYAYFLLGETNKALVKFERATSSEQDDYFDPVLTHQRWAQCLEEKRQREGSELQLEEARRVREKILETPLEEDQLDYFSDDFDHYSTKEKPGFVRILQDYHFWAAHSKRRTSELNPPESQDPAYPRNTRYRYDFFVWHAERDSRWTVAFVHKLESEHGLVGSIQRRDFEVGRDVSSDVIRCLRQSYRFVIVLTPRPSSAASSGWESFAINQAVMEGGRRGGEYIVPIKLRESAVPDVLQTLTVRECEEGQILKQHWDELVRKLTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUW7</accession>
    <name>A0A8B7YUW7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450 4F4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097104.1">
        <property type="nucleotide sequence ID" value="XM_022241412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUW7"/>
    <dbReference type="GeneID" id="110982767"/>
    <dbReference type="KEGG" id="aplc:110982767"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20659">
        <property type="entry name" value="CYP4B_4F-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022097104.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="60823" checksum="50631508ACDD6F02" modified="2022-01-19" version="1">MALGIAVSVALVAALAYVAYFLVGTVRSIRKRREVLLQWPGLPVHWLYGNLHQHPLTNPKIRTESPEEGFAFHCAMTEKFPQGYRLFYGPTRGEILANHPDIFRPIMKGRDPKPLMQGQPSYNFMRPWLGDGLLLAKGDTWVRNRRLLTPAFHFDVLKPYIQVYNEAVDVFMAKLDKCVRGGASFVVTKNVSLLTLDILLRCAFSYESDCQVQGDEHPYVKATMELSRIVIDRMFSMLLYFDLPFKLSSMGRRFKKSCDFVHQVADEVIKRRRAHLEAKKHNPDAGSDRKYLDFLDILLSARDEDDKGMTDMEIRNEVDTFLFEGHDTTASGLTWMLYAMATHPEHQRKVQEEIDEVMSGRESEDVGWDDLGKLKYMVQCLKESMRMYPPVPFIMRVLERDVEIDGKILPAGTNLDMAIYCLHHNPQVWTDHMTFDPDRFSPDNIQKIDPFSYLPFAAGPRNCIGQNFALNEEKVILVRLLRRYTIQLDPSHPVKFSEFAMVPDNVCCWTTGLLDCVTWTSCCVSRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YV62</accession>
    <name>A0A8B7YV62_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Indole-3-acetic acid-amido synthetase GH3.3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095216.1">
        <property type="nucleotide sequence ID" value="XM_022239524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YV62"/>
    <dbReference type="GeneID" id="110981712"/>
    <dbReference type="KEGG" id="aplc:110981712"/>
    <dbReference type="OMA" id="PRWTAGH"/>
    <dbReference type="OrthoDB" id="10004661at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055378">
        <property type="entry name" value="GH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055377">
        <property type="entry name" value="GH3_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901:SF9">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23572">
        <property type="entry name" value="GH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23571">
        <property type="entry name" value="GH3_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 middle" evidence="2">
        <location>
            <begin position="408"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 C-terminal" evidence="3">
        <location>
            <begin position="502"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022095216.1"/>
        </source>
    </evidence>
    <sequence length="635" mass="73052" checksum="70915BD9D564D8A3" modified="2022-01-19" version="1">MTWAFRFLLLGLGSAGFTLQIYKYCLTTDTNGIWKVAAVFLTFLGAVFSLVNFHISSLRCSESHTLRSLLVSYVCQNLTRLAYPFVLYKVSKQWKKPREAQKHRLRLLTTRDAETEYGRRYQLGQIKTLKDLQSKHPITTYDHYRPYVQRLADGEEGVFIGEKIHRFGITSGTTGAGKLIPLTNEIYDDNDVTVLNTKATDSAFGRPSPLQRGCILYCKPASFVAKSGLDVAPLIYFMEKDKDILTILQNAPFAAFQITTDFEANYVHLLFGIADRYLHFVYGGFTSITYRAFRLLEDNWEQMLQDLATGTLNPKLNIEDEIRHQLEEALVPAPARADQLRVEFSRGFHGIVSRIWPFLHYIFCVDVAGYGNKLREGYAKGTPIFTGAYGCTEALLGINLWADEDPKYVLVPAKVVYEFIPEEICQEKHPSQIYLIDEVEVGKRYELMVTVPCGFFRYRFGDVVEVVDLYYNCPVIQMRYRTGELLNLRGEKIDISLLSTVIWQTVASWQQCTLVDWTCAESPLIHADKVPYDMHYLIFVEVEAKKGQCLTEEEKSQFDQLLRKCHGLYDHYRTAGNIAAPRVFNVCPGSFKKFQDYVIAKTTASYNQFKMPRKLHRKELLDYMMSMTTEYREPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVM9</accession>
    <name>A0A8B7YVM9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC110982564</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110982564</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096747.1">
        <property type="nucleotide sequence ID" value="XM_022241055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVM9"/>
    <dbReference type="GeneID" id="110982564"/>
    <dbReference type="KEGG" id="aplc:110982564"/>
    <dbReference type="OMA" id="HEMSTPQ"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000324">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008103">
        <property type="entry name" value="KiSS_1_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF23">
        <property type="entry name" value="GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01728">
        <property type="entry name" value="KISS1RECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="843"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="179"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="601"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="893"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="916"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022096747.1"/>
        </source>
    </evidence>
    <sequence length="932" mass="104197" checksum="621F5AC3093E72A1" modified="2022-01-19" version="1">MDKEGGASTVKGGNMTYRQERATPHTSVRTDTLGLKVHGRDDPGKSTSRFHLIIFARDFRAWCIGHILPDSEPISSSPHGRIHSLIRSSPPPQPLHVVCFCNWRVSAFGRCGHLIGHFGGKKMTTALLFLSTALDDNTVVPNSTEAPWTGDGGSSYLFPFPPWLIPVILGILICVGMVGNSLVIFVIVRASQRTVTNYYIVNLAVADILFLAFCAPKTANDYLNQGFTLGRFMCKVVLYLQYVTSHSTCFLLAAMSVDRFQAIVRPLKSLKTRTLQTAITISVLVWLSAFLLYIPFPLYFDLQELVYQGTLTTYCLISWPSGTLEFAYTIMTFLFPYALPLVVIAVCYTVMLRHLWQRVAPSDAVSGPANTANTERNLRQKRKITLMVLTVVIVFTVCWFPLHFYSLWSSFGASFVYTNHALNLKTAGHVLSYVNSCANPFIYAFLGENFRKSFRKAFPCCFKRARADRDEARRGVTGANQGSTLVAGPSTRTGSNTQMSSLPSRVDIEKLYRETALIELKITEICLKLVCRRNWRKADNLEGKMTTAMMPYRFISTAEGNGTLTSFATSPPESDTTSNLAYLTWLMPVIFSILITVGVVGNTLVIYVIIKASKRTVTNYYIVNLAASDILFLAFCAPPTAAHYTAPAFYFGRFMCKTVYYLQLVTAQATCFLLTAMSVDRFHAIVRPLKSLRTRTLQMAVLISVSIWLFALIIYIPVLIFFDIEYIDFHGVEPYCTEHWPSKTWNRCFVVVSFVLVFSLPLAAIAVCYGAMIRHLWKRVVPNDALSGQADAVNTARSLMQKRRITWMVLAVVVVFAVCWFPIHVVNMWHRLDPNFPFTDGTFYFKTVGHVMSYCSSCANPFIYAFLGANFRRSFRKAIPCCFRQAGLQTDGRGGTTGSPHGSMRVGASSRGARASYNNTEMSDLNSKTTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW07</accession>
    <name>A0A8B7YW07_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Very low-density lipoprotein receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110982976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097498.1">
        <property type="nucleotide sequence ID" value="XM_022241806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW07"/>
    <dbReference type="GeneID" id="110982976"/>
    <dbReference type="KEGG" id="aplc:110982976"/>
    <dbReference type="OrthoDB" id="10069070at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043555">
        <property type="entry name" value="SRPX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343">
        <property type="entry name" value="HYR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46343:SF2">
        <property type="entry name" value="SUSHI_VON WILLEBRAND FACTOR TYPE A_EGF_PENTRAXIN DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CUB" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="6">
        <location>
            <begin position="125"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022097498.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="23641" checksum="F9A322F69F57CE69" modified="2022-01-19" version="1">MTWIIQCVDGQIVRLTFSSFETERDQDYLLAGDGNDITTGQFFVWHGSKSPPNLISSGSEMWIRFTSDFEETSSGFLLLAICLPSTEILTCGENEFNCGHSVCLVDMWQCDGLTDCLDGSDEENCDSEAPTVTCPNTVMIGTDTGRSFATVTWTPIPTATDNTDILTSSDISCLDSRGNVVVSGGTNELGTTTVTCHATDAATNTGSCEFSITVVGKFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW54</accession>
    <name>A0A8B7YW54_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">G-protein coupled receptor 54-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC110982543</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096714.1">
        <property type="nucleotide sequence ID" value="XM_022241022.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096715.1">
        <property type="nucleotide sequence ID" value="XM_022241023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW54"/>
    <dbReference type="GeneID" id="110982543"/>
    <dbReference type="KEGG" id="aplc:110982543"/>
    <dbReference type="OMA" id="MGNNFRT"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008103">
        <property type="entry name" value="KiSS_1_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF23">
        <property type="entry name" value="GALANIN-LIKE G-PROTEIN COUPLED RECEPTOR NPR-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01728">
        <property type="entry name" value="KISS1RECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="49"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022096714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022096715.1"/>
        </source>
    </evidence>
    <sequence length="376" mass="43514" checksum="D6DF98F5A53390FC" modified="2022-01-19" version="1">MPCLEPEFGDAGWANFSYYDDYQSDGRPHPETILVPLSWSLIVAVGVITNALVVFVVVLQMKMSTVTNYYIVNLALTDLTFLLFCIPFTTMTFIPHSFLNDGICTVVMYVQQASVHATCMTLTVMSADRYFAIVFPIKSLKYRTRRLAFLLNLGVWILSYIMAVPSAVFVEVFHQDDYWTCCETFHTHRDRGVYYTYVFLTTYIIPLAIISVCYSLLLFEMWTKHNLTASTTLRARKNLQQKRRTTRMLLMVVFLFFVFWLPTHIFNCWDRYTNGGPDFSKHEALYNFRIFSYTLAYSNSCVNPFVYAFMGNNFRTSFKKAFPCCFRRQIGARGSTRRMQRRGTVDGATRVTVLAPREDIEMNMNNNMAPMVQAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXD4</accession>
    <name>A0A8B7YXD4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Pre-mRNA-splicing factor ISY1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110982093</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095940.1">
        <property type="nucleotide sequence ID" value="XM_022240248.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095941.1">
        <property type="nucleotide sequence ID" value="XM_022240249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXD4"/>
    <dbReference type="GeneID" id="110982093"/>
    <dbReference type="KEGG" id="aplc:110982093"/>
    <dbReference type="CTD" id="100534599"/>
    <dbReference type="OMA" id="YHWERRI"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022095940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022095941.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32940" checksum="1DC74AE7E0D5C992" modified="2022-01-19" version="1">MARNSEKAMTKLARWRQAQMEEGKVREKRPYLATECEDLHKAEKWRRQIISEVSKKVAQIQNAGLGEFRLRDLNDEINKLLREKTHWEARIVELGGPDYRKIGPKMLDKEGKEVPGNRGYKYFGAAKDLPGVRELFEQEPPPPPKKTRAELMKFIDADYYGYRDEDDGVLVPLEVEHEKQIIAAAVSEWKSKKEAGLLSDEVTKEQEVEEDIYAITHDPESEDEEESTEMETEEGQPRYVAHVPVPTQKEVEEALLRRKKMELLEKYASETLIQQGNEAKTLMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YY12</accession>
    <name>A0A8B7YY12_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein-lysine N-trimethyltransferase SMYD5</fullName>
            <ecNumber evidence="2">2.1.1.359</ecNumber>
            <ecNumber evidence="10">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SET and MYND domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">[histone H3]-lysine20 N-trimethyltransferase SMYD5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">[histone H4]-lysine36 N-trimethyltransferase SMYD5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110983347</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:54193"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="2"/>
    <dbReference type="EC" id="2.1.1.372" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022098229.1">
        <property type="nucleotide sequence ID" value="XM_022242537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YY12"/>
    <dbReference type="GeneID" id="110983347"/>
    <dbReference type="KEGG" id="aplc:110983347"/>
    <dbReference type="OMA" id="LMAMYQQ"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10521">
        <property type="entry name" value="SET_SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044422">
        <property type="entry name" value="SMYD5_SET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="19">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022098229.1"/>
        </source>
    </evidence>
    <sequence length="417" mass="46589" checksum="DFE7DC553099F22D" modified="2022-01-19" version="1">MAASTGMCFTTTTIADGAYGNKGVCVKVIDELRGRGVFANGDFKSDDTIFRESPLVCAQFLWNGFYRYTACEFCMRSMETAQEMARRLSGNPSLVLPHPECCTVHKERHTACPQCQVPYCSAECQDHASAQYHQVLCLGQSPPDPDHPLVFLQETWKNMHYPPETASITLINKMIATVKQAKNKEHVLHTFGHFCQKAKSEEQQLAHKLLGSQFQGQIDALQGLLAEALYEDCISRWFTAEGLRSLFALVGMNGQGVGTSSLSVYVHNCDALDLPDDERQALDSFIDQLYVDIEQESGTFLNCEGSALYQLQSCCNHSCQPNAEIQFNDNNSTLTAVALRDITEGEEICICYLDECSRVRSRHSRQKILRENYLFHCGCIKCLEQCDDADQTSSDEEEEGEEPQDLEGGDKEAEMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZZ1</accession>
    <name>A0A8B7YZZ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Actin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10" type="primary">LOC110982570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096761.1">
        <property type="nucleotide sequence ID" value="XM_022241069.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096762.1">
        <property type="nucleotide sequence ID" value="XM_022241070.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096763.1">
        <property type="nucleotide sequence ID" value="XM_022241071.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096764.1">
        <property type="nucleotide sequence ID" value="XM_022241072.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096765.1">
        <property type="nucleotide sequence ID" value="XM_022241073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZZ1"/>
    <dbReference type="GeneID" id="110982570"/>
    <dbReference type="KEGG" id="aplc:110982570"/>
    <dbReference type="OMA" id="RAWSAWL"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000188">
        <property type="entry name" value="Actin like 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022096761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022096762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022096763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022096764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022096765.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="41575" checksum="5D1B7789E07B4BC0" modified="2022-01-19" version="1">MSSVRTIVIDCGAYQTRVGISGRDVPEESFRTLVGRKKEGSISTSEASDVLIGEDAYEIRDTLNLSYPVDKYRFAFDNTEDLCNIWKFSYLDVLGCDSLEECPVLLTDGPLEATEKAKSRAKLAEIMFEKYKVPSFYMALQQFLALISLDRTTGLVVDVGDSMASTVPVVDGAVVHEAIVTSDVVAGRQMTDLLMKFLNEREDISIADREIAMAIKEKLSYVACDYEGEFKFAGSATKDYTLPDGQVISVGTERFRCTEPLFQPSLLGAVDSPGLHEMAHRSLELCAESARVPLRGAIVTAGGSTLTTNLSDRLKLEAKALLAGHGAEVRVLTPPMRAWSAWLGGALLAEWEGYPELPVSRQEYQEHGAEFVIKKFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0D4</accession>
    <name>A0A8B7Z0D4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110982637</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110982637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096891.1">
        <property type="nucleotide sequence ID" value="XM_022241199.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096892.1">
        <property type="nucleotide sequence ID" value="XM_022241200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0D4"/>
    <dbReference type="GeneID" id="110982637"/>
    <dbReference type="KEGG" id="aplc:110982637"/>
    <dbReference type="OMA" id="AGAYWYY"/>
    <dbReference type="OrthoDB" id="10330056at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694:SF11">
        <property type="entry name" value="LP21121P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36694">
        <property type="entry name" value="PASIFLORA 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096892.1"/>
        </source>
    </evidence>
    <sequence length="169" mass="18581" checksum="3A898B1A31023C61" modified="2022-01-19" version="1">MAILDQHCFCCVSLRKGALVSTIFFLLVAAATALLYVWGLLELLQRESSFDSSAQQTSILVLTYILIGLHGVVMILAAIIMFIGAFCYSPGSAAFFSVVIAIGTVIELGCIVYLGVITENQLQGLASQPYFLFLVIWFAIRAIWNMHLVITSWSLYQQLTSKGYLAGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0G9</accession>
    <name>A0A8B7Z0G9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptides B/W receptor type 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110983826</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022099098.1">
        <property type="nucleotide sequence ID" value="XM_022243406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0G9"/>
    <dbReference type="GeneID" id="110983826"/>
    <dbReference type="KEGG" id="aplc:110983826"/>
    <dbReference type="OMA" id="EWMRTIT"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="68"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022099098.1"/>
        </source>
    </evidence>
    <sequence length="410" mass="45804" checksum="258B2BB715122743" modified="2022-01-19" version="1">MSELNDTLDAIHFIDARTQSICLTMEVTYNLTNEVNAQWFLGTYAYSWSDTLVHTIILPFILSVGLLGNVAFLIVVLRIEWMRTITNCYLVNLAVADMTFLVVSIGEKLHQYTRTPFVYDDLPKGPTGCILVPFTKDLCFFSSLFLVTCISAERFNAACRPLKQRQSKGAKLRARTARLATGAWVLSLAMASLRVSASCCRYRVYCLLWPDNDAYLDYPGVVGECRPAAEWIAIVAKSIQLVLFVLAMAVNTAFYVKITRAVQCTSARPHARRVPSTGSSSIEAKITRMVVATGVVFFLCLAPYELLSALVMILPTFDGNIVSAMQVCRMLVHLNSAINPFIYNVANPRYRRAFRVVFTCSRAGRTREFSQNTKDVPTRPPNANTSDRSTFLKQKSHRGQSTQGFCSTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0Y6</accession>
    <name>A0A8B7Z0Y6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sulfotransferase family cytosolic 1B member 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110983910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099268.1">
        <property type="nucleotide sequence ID" value="XM_022243576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0Y6"/>
    <dbReference type="GeneID" id="110983910"/>
    <dbReference type="KEGG" id="aplc:110983910"/>
    <dbReference type="OMA" id="YCLFCRG"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022099268.1"/>
        </source>
    </evidence>
    <sequence length="158" mass="18627" checksum="D6ADA763936F6A65" modified="2022-01-19" version="1">MIVSFYHFEQMLNLKGSGQSFAEYLEYRNSTKASYGSWWDHYLFFWKRREEPNILLLRFEDLKKDLRAKVEQISRFLGKDLPAETLDAVTEHCTFANMKENPMTNPDTLYAPRDKLESTFMRKGKSGNWKTHFTVAQNEAMDVLIEEKLRGTGLTFDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1Q5</accession>
    <name>A0A8B7Z1Q5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homeobox protein MOX-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097331.1">
        <property type="nucleotide sequence ID" value="XM_022241639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1Q5"/>
    <dbReference type="GeneID" id="110982886"/>
    <dbReference type="KEGG" id="aplc:110982886"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022097331.1"/>
        </source>
    </evidence>
    <sequence length="181" mass="20200" checksum="224A7F602E78C5A8" modified="2022-01-19" version="1">MPASRPTLNKHVGKAGYLKNPDIHQSASDSPQQGHYPYPNSHHQPPHHHPHHHYHHHYPSQSQGDALPMQAPISVGDHLRKDSRSEQSSDSPNDFPTNPKLLKKMSNEMTRRLDSRSDRSYSPASTIQLLEERGTLPTAGSDVSGGLESKPEDTKSWLNTRASRASLPKLEGGVTSRQFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1S8</accession>
    <name>A0A8B7Z1S8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 10-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110983733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098927.1">
        <property type="nucleotide sequence ID" value="XM_022243235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1S8"/>
    <dbReference type="GeneID" id="110983733"/>
    <dbReference type="KEGG" id="aplc:110983733"/>
    <dbReference type="OrthoDB" id="5402602at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF17">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 10-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022098927.1"/>
        </source>
    </evidence>
    <sequence length="377" mass="41049" checksum="1983C9035EF7FEDC" modified="2022-01-19" version="1">MMEKSPALGFWDKSSEDQLRGRFPVHRACRDGDTAALSVLLAHGEYDLYTEDHFYGWTPAHWSAYYGKLDCLQLLVTAGVNFDVATQRFHQTPAHVAAFGNQPHCLMWLIQSGASVNAQDYLGETPVHKSARSGGIECLGILKANGAIFRIANNNGHMPKDLALSCSNEPCALYMQQVEDSHHVPNGFSSRDLGRKRGTDDIVNGDLKKARTEDGVESLPAFNGKPSNGTENALTSNGLSMPSIHVGDPTSPPKCSIGIQAMPSPCMHLPHPQDTGPERLQSSELVSLYTEVDLGIDESQCDLQHNSHMAMQTEHHLGNGVTETMDINNHQSGFQNGAVPVSVSASAMEHEAAVAMTLGYDSMYDSIYNSVGYCHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z244</accession>
    <name>A0A8B7Z244_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110983685</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110983685</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098841.1">
        <property type="nucleotide sequence ID" value="XM_022243149.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098850.1">
        <property type="nucleotide sequence ID" value="XM_022243158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z244"/>
    <dbReference type="GeneID" id="110983685"/>
    <dbReference type="KEGG" id="aplc:110983685"/>
    <dbReference type="OMA" id="RNMDISH"/>
    <dbReference type="OrthoDB" id="10563264at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665646" evidence="1">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022098841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022098850.1"/>
        </source>
    </evidence>
    <sequence length="229" mass="25615" checksum="9BC94E871FCB68B7" modified="2022-01-19" version="1">MAASVSFAFLMCIMLVTCALARPIGCQDSDRSSSPLARLMRRSAAIASRLRLLRSLRERRWARSYPIWKTLHRVQERNMDISHLPPLPLPDTEQHARDFDQIRAAVEKDSEGNKNSWVVGDVFEGGSWGSKPVFFSEVPNPEEEKGAEVESDLNEGWDNGNPPIENEDNSDADWGEYKNPYLDCIDDNIVGIPCTRDSDCRGCTAYHCSASTNHCVAGPRPHLSFSGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3F3</accession>
    <name>A0A8B7Z3F3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E3 ubiquitin-protein ligase BRE1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100164.1">
        <property type="nucleotide sequence ID" value="XM_022244472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3F3"/>
    <dbReference type="GeneID" id="110984347"/>
    <dbReference type="KEGG" id="aplc:110984347"/>
    <dbReference type="OMA" id="YLFQAPM"/>
    <dbReference type="OrthoDB" id="10036725at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100164.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46626" checksum="ECE1EDA1E0C601D0" modified="2022-01-19" version="1">MASTEVEDLYRRLQTFQLQLKVILDRNNEVLSHLEQVEASITGLDSSVVNKDAIRGSIKVCRVSSKQVQEIAESQCGSLEGQIRELARYSDDDLHGDINRVPDTTFSSVKQQLMSQLDYNVALQKDKAALETRLAEKLEKLAQVNKMNETLQGDVEESQEKMRSVLERLDKTAKDAEDRLDCLEKETKKAQKASEEYQRLYEAEKQRVEHYEKERGENRNPAKRRQASTSSHRDLTAMARQTRTSSTTPYLFQAPMTRVKSADRVRPKDMDTKYLCLVDKNRSLHMEVRRLRDENAHLMRSSKDSKRDVEIIQRYIATCQTQRNELQVRLRREQEEHRRLATSMNKQASNWISEKKMVRGMETTSKTAKIQSESVLGASRRLKLHSVKLNEDKPRDIPVQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3X8</accession>
    <name>A0A8B7Z3X8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Deubiquitinating protein VCPIP1</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Valosin-containing protein p97/p47 complex-interacting protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Valosin-containing protein p97/p47 complex-interacting protein p135</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27 28 29" type="primary">LOC110984010</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28 29" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Binds VCP and the ternary complex containing STX5A, NSFL1C and VCP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">Golgi stack</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022099475.1">
        <property type="nucleotide sequence ID" value="XM_022243783.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099476.1">
        <property type="nucleotide sequence ID" value="XM_022243784.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099477.1">
        <property type="nucleotide sequence ID" value="XM_022243785.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110984010"/>
    <dbReference type="KEGG" id="aplc:110984010"/>
    <dbReference type="CTD" id="80124"/>
    <dbReference type="OMA" id="KHSTETD"/>
    <dbReference type="OrthoDB" id="10012024at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090168">
        <property type="term" value="P:Golgi reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22769">
        <property type="entry name" value="OTU_VCIP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000146">
        <property type="entry name" value="deubiquitinating protein VCIP135 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000004">
        <property type="entry name" value="deubiquitinating protein VCIP135 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039087">
        <property type="entry name" value="VCPIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045827">
        <property type="entry name" value="VCPIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14843">
        <property type="entry name" value="DEUBIQUITINATING PROTEIN VCIP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14843:SF2">
        <property type="entry name" value="DEUBIQUITINATING PROTEIN VCPIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19437">
        <property type="entry name" value="VCIP135_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="25">
        <location>
            <begin position="177"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="632"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="758"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="910"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1039"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1101"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="693"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="711"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1139"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1150"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1186"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1240"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1286"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1357"/>
            <end position="1366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00071253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022099475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022099476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022099477.1"/>
        </source>
    </evidence>
    <sequence length="1372" mass="150445" checksum="E697578C5029C100" modified="2022-01-19" version="1">MLSRSSSQIEDRYRMLSGYCPDSQCQTKLYFPSFDSSIECTGCGQRHERGTLHNVQEVTDPEVALHNIVRNLLVGNAAPKQTADSVKVLGLSNYHCKLLSPLLTRYGMDKQGRAQPLSALSQGAEVFDCSLLGGRAFLLQPEHVGIMGYGRDQTGSAKYLRDTLEFITQLNGNQEVLIPIHADGDGHCLVHGISRALVGRELFWHALRTNLKSHFLSHIAQYKNHFKDFLTESSEWAQIITESDPDYMPTETEAFGLQNIHIFGLANVLHRPIILLDSLQGLQSSGDYSGVFLPVFVPREECCGKDGMLNKPLCIAWSSSGRNHFIALVGVKGRPLPRLPRGMLTKAWGAPHELIDTYIEFDKDDMCTVGGDRSLPDKYVQRLAAAMEEVFVEKYSLHPSVVADVHHYIYKRTGVVGVPQNIIIENTRHALEHQQLFRCLLCSAVSQIEKTSVPSGWLGRGGELYGLATKLHGRLIEGKVYTFPLHELNCTYDAVKDELVPDQSTMRPSQCAWCQGKQLRQIRTDGSVVYFNGDRTTTPAPKTKCNCGFKHYWNGIEYDNNPSIFTVPLKWKGLSYLEEVLWFQDESDPALNSNAYDIASALVQKHFPGEFGSEKLVQQVVETILQNTAGQEEEFQPISLKDMPTTSTADQSAAGFAPAQGGDTPELKRGLKGDAGGHTPKHSRPKDKDGHAGRSASPASGRSSPRVGSPAEKKGGKLDESPSKIILTGHAAKTLHKEELTMSEAERNLRKRIQDKAPVVQHHHPSLEESGKQPSPSTPPSGRAPTQREDVVQGSPQGGPKEEMAKATDIAMETVVQATKEPPKQKRIRLTSSDGKQATLVLDPSTTFAQLQAKIEAEFHIEAADQKIRYGFPPKELTVPAEGDQEDQPVPLQNGDRVTVEVISKVQPMEVGPSEHGQHSLSTLPGSSTLMEGGGRSLNREEIMRGMENLQQDTGDTLDLQLYSLNLMATLMNLDMWAYVQQNATLFERGGLFYAIVERDLGLADGKHFLLPSIPNKKFTYNAMEDRIEICLEPIGHFPIRPGVDDSDSPSTSRPSPSSTDPEDKDRSEYITSVRSKLKAGGSGVVTTGGKQVGGYRAFSGHAHTLSSGGQRLDGGTSSSSSSQQQEGWEMPRWTQYQREFKKLLDRQEQQAPEAQLSGSGQSSEAVEMPQGSSVEQLGVLAQEPMLSNQRATEGQRLRPTTQEGLREEIMDSSISDSGEGRAGATDISHGTVDIASGNRETEQSKSKSEEGSTERDIPMEVSREASVQQRAPLSTLPMEVDSKNDNLQNTITVQSSLPDGRESISDDAAPAPTQEQRLPEGEPVQATSEPKDEGMPVYVPKRLGPGYTVLVEQTPPGASTPSPSDEQSHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6U4</accession>
    <name>A0A8B7Z6U4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110983790</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022099046.1">
        <property type="nucleotide sequence ID" value="XM_022243354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6U4"/>
    <dbReference type="GeneID" id="110983790"/>
    <dbReference type="KEGG" id="aplc:110983790"/>
    <dbReference type="OMA" id="EGCENEA"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20341">
        <property type="entry name" value="BRcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16628">
        <property type="entry name" value="RING-HC_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000186">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031128">
        <property type="entry name" value="RNF14_RING-HC_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="11"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="210"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022099046.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="56898" checksum="715D92F054653866" modified="2022-01-19" version="1">METDDQVAQTDEVTALASIYEERIFLADGNNGGHFSAYLDLPEEFFIELHEASLVHRTRKLGCRLEEGHEGSSLLRINHLPPIVLNFKYPEDYPSRSAPTFTLSCKWLNVDKLSELRSHLDRIWDEHRGEVIIFQWTQFLIDDSLWVLRIQSSLSLGSAAVQLAQGDSTELADTSGPHSVKNKSVRGAGQLLQTLIDYDISERRRVFDESIHSCSVCFSEKAGVDCVMFQSCNHVYCKDCVRDYFMVQIKAGNVKALNCPDTECDSVAMPPQVYALVGEELFATYDRLLLQRTLEGMDDIVYCPRLSCQCPVMKDGESSLAVCSACGYSFCVLCNRVYHGVSPCVASEEEILKVLVEFEDGDEDCKVRLEKRYGKDLFKDLREEAEERRRQEELAELGRLKEAEERRKERELAEKEPLKQRMQNQRWKNNNTKQCPTCGTHIEKNQGCNMMKCTHCNKSFCWRCLQVLPHTYSCDSVFDYLQQAKTANEESTTGILASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7Q9</accession>
    <name>A0A8B7Z7Q9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110985167</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101694.1">
        <property type="nucleotide sequence ID" value="XM_022246002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7Q9"/>
    <dbReference type="GeneID" id="110985167"/>
    <dbReference type="KEGG" id="aplc:110985167"/>
    <dbReference type="OMA" id="NTCNDRV"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000005">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000019">
        <property type="entry name" value="Bc1_11K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022101694.1"/>
        </source>
    </evidence>
    <sequence length="93" mass="10931" checksum="1DCF5F24F8EBA093" modified="2022-01-19" version="1">MAIDDERLFENDPPEEEEEEEEEEEEDLVDPREEVMENCRQDGHCAGFKQELEACTERVTGRSHTEETCTQELFDFLHCVDHCAAEKVFKHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z976</accession>
    <name>A0A8B7Z976_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">A disintegrin and metalloproteinase with thrombospondin motifs 10-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110984996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101360.1">
        <property type="nucleotide sequence ID" value="XM_022245668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z976"/>
    <dbReference type="GeneID" id="110984996"/>
    <dbReference type="KEGG" id="aplc:110984996"/>
    <dbReference type="OMA" id="HEYLISP"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034450171" evidence="3">
        <location>
            <begin position="18"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="4">
        <location>
            <begin position="222"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022101360.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="46420" checksum="05D56AF6D418224D" modified="2022-01-19" version="1">MMLKIVVLAVLVSTACSKPGVLNKDDEFSTEELIRYFGVENHAEAPEYEVVYPLVVDADSKRSVGNGAIAASFLELEVEAFGETLILNVDHDDSNYAPGLEVEIYTDEGIQRVPLRTDCVYTGKVAGEQNSIASVTTCDGLMAVIFRNDGRGELYIEPLEDKHAAKRDVGRGHPHVAYKNRPQKGGAFCSAIDPPVLPISSLADPPIMPISAEEPVDTESTKYLELAFIADPSYTSSRGSTSSATTCVNTLFNAVKNVLQLSSLRGTALVPKLVYVKIFGATETGLTSNTDSNTYLATCRAWQHTNNKPSSSSEHWDNAAFFTGVDISSPDAGNAVLGVGYVSGCDYWGASLSEFRSLDATAVTAHEIGHNLGMYHDSSGPEGGPYNSCSSKGYLMAAYNDNHQKDLGWSTCSRSYYDTRITQTTCYNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB55</accession>
    <name>A0A8B7ZB55_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Neutral cholesterol ester hydrolase 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9 10 11 12" type="primary">LOC110985378</name>
    </gene>
    <organism evidence="6 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102046.1">
        <property type="nucleotide sequence ID" value="XM_022246354.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102047.1">
        <property type="nucleotide sequence ID" value="XM_022246355.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102048.1">
        <property type="nucleotide sequence ID" value="XM_022246356.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102049.1">
        <property type="nucleotide sequence ID" value="XM_022246357.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102050.1">
        <property type="nucleotide sequence ID" value="XM_022246358.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102051.1">
        <property type="nucleotide sequence ID" value="XM_022246359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZB55"/>
    <dbReference type="GeneID" id="110985378"/>
    <dbReference type="KEGG" id="aplc:110985378"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF32">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665688" evidence="4">
        <location>
            <begin position="22"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="104"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="315"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022102046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022102047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022102048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022102049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022102050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022102051.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="44880" checksum="2C4E39CA98F8E960" modified="2022-01-19" version="1">MGVIPTAVLLCLVGLAIYVYLEPIPDGIEIPWKMKFVTRCIRISTRLASLMPKRLSAWFAAKVEEARVSGGPNITFTDTTYGGVLVRVFADKPDGENAAKRPAIVYYHGGGWTRGNIKFYHRLTAEIAEETGSVVISVEYRLTPDHIFPAAIDDCTAATVGFLQHLEDFNVDPTRVAIMGDSAGGNLAAAVAQRLTFMPQYKDLPKLRMQVLIYPCLQAFDFQTPSYQQNGDYVTLMLDRAMMAGFWAVYLDNRPSLTTSMSVNQHTSVKAKGSSLVKKCLSHDLIPEEFKQTGYKEPSTNFGNEGIYEEIKRVLLDPDYAPLMREDLRGLPEAYILTAEYDVLRDDGIMYAKRLEKAGVLVTWKHYKKGFHAMFGSKNGPFASPSGNLASADLFEFFKEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCC9</accession>
    <name>A0A8B7ZCC9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATPase family AAA domain-containing protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110985722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102637.1">
        <property type="nucleotide sequence ID" value="XM_022246945.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985722"/>
    <dbReference type="KEGG" id="aplc:110985722"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05528">
        <property type="entry name" value="Bromo_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000016">
        <property type="entry name" value="ATPase family AAA domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000734">
        <property type="entry name" value="ATPase family, AAA domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="979"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="269"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1099"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="938"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1145"/>
            <end position="1158"/>
        </location>
    </feature>
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        <location>
            <begin position="1185"/>
            <end position="1198"/>
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        <location>
            <begin position="1219"/>
            <end position="1228"/>
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            <begin position="1303"/>
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            <begin position="1335"/>
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            <begin position="1376"/>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00023117"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022102637.1"/>
        </source>
    </evidence>
    <sequence length="1500" mass="170547" checksum="A6557A4A59F72F2F" modified="2022-01-19" version="1">MVKTRRSSPLEDHDYGEEFLSLSSRRSRRQPRANEEVDVSSSSDVTQKCKQDGTNLRARSVNSNNSIAQSRMRRNRSLRMDDTKITSYSPVRTRRSAKMETEQEPLTEPVTIDNIHLAEFEEEDHEFIPRRSMRARKPLYTTMNTNMIVNHVLSALQEDKAAKSIQKKRNNIDEEEEEEDEHQGSDDEEVDSTSLDMYSRIKRRHIKRRSLAEEEEEDTEDEGSDQDSDEESSEEEEEEDPPTRNYGLRQHRRIVQRYEAPLQETIPRKRPIRLFDKSRSPLRRHYRSHSKPLTPIRGQHFKRKHHAAHNRSSTSTDSSDDEMHFERRKKKSMARSRMRCLPMNMVPEDVTGIMKDRQKIGSSLADVDPMNIDTTVTFDCVGGLNQHIRNLKEMVVFPLLYPEVFDHFKMSPPRGVLFHGPPGTGKTLVARALANECRQEDKRVSFFMRKGADCLSKWVGESERQLRLLFDQAYIMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRIDAIDPALRRPGRFDREFSFPLPSQEARRSILSIHTTNWSPKLSDAFISEVAEKCVGYCGADLKALCTEAALFALRRQYPQIYASKEKLQLDVTQIQMSAKDFHKAMKKVVPAAQRSVVSPGRALSVIIQPLLQNQLNAVLEQLHRVMPAAVTSSDKATTSGDISSSSAASKMVLDVTDEYDDYSEEEGPCIFDKSSTQSDGKRKKSVCDREQSSYSFMDFSSAAYERPSTHRPRLLLSGAEGQGQSSYLGPAVLHHLEKMPVYRLDLPALYSVSVNTPEECCAQIFREAGRSSPSVIYMPNISRWWETITDTTRATFLSLLLDLPPNAPVLILATSEKALHEVPLEVRELFSDYRGEVYRVRLPSPEERHAFFEDLILHQTCKPPPRKRRAVAGSLEVLPVVAPPEPRRLQEEELKKLEEREESTLRELRLFLRDVLTRLANEKKFRHFLRPVDLEEVPDYLTVIKNPMDLSTMMNKINMHHYNSGRDMMDDIDLICQNALEYNPDRDPGDRAIRNYACELKDTAYAIIEAEMDKDFEKECLDIKESRMNRGQSPAKTAPLYYRVLPPSMLPASQEPPKLKPVREQPANLKRKNDTPPKINPVSGLTDPFSQSKSVKRKKQTRLRSRWNRGFITSARKKKKVTSTTEGSTKLDPDGTEEVENKEEDSVTENASSIEVEADSNLEPVSPSHDERDDRSNFHQTDAPPSCLQENGPVENGIESNGMPDELEASRHSQMTNDRPCSENDSIKSGEVHRDARPIRSRLRSSASSHSDNNPTSPKSTSLIHSTNGTEHSTHAASKAPDVSNGTDQFEQSRGTSRSEMASVDQNTSGAIQRQTRNHPPSAEMEGKNVTRSHPDDTRMGSFDREETVAVEAGGSPSPRRMTRRMWADMTAPKIVGKPEETTPVLVADHKRLKALLSTVVQRTSGSNVETLERLHCSLSQFIYTHRMEYDKTQLITDMESEVLCFVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCE3</accession>
    <name>A0A8B7ZCE3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110985730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110985730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102652.1">
        <property type="nucleotide sequence ID" value="XM_022246960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCE3"/>
    <dbReference type="GeneID" id="110985730"/>
    <dbReference type="KEGG" id="aplc:110985730"/>
    <dbReference type="OMA" id="IALKTCC"/>
    <dbReference type="OrthoDB" id="10308298at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50270">
        <property type="entry name" value="NGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022102652.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26311" checksum="2A1F54C5912D2445" modified="2022-01-19" version="1">MVSLRVRERLQVSALLALTFVAFAGARYTPSKYYDENEEHSRLPNDSVQQFIDTLRIPPQLSPVTNDFPTREDFLRMPSMEGADAQRIAFGESKPTHSPAVEIPLTPRNRRSLSYPFYKRSMVSSEETVRACEAQSDWVQITRATALENEEVILGTRQWFWQTTCLDEGGKCYGFMETPRMTSSCRPVFSWVVAWARPESVMNYTWRFIALKTCCSCAVIKASSNLPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCP0</accession>
    <name>A0A8B7ZCP0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Prostamide/prostaglandin F synthase</fullName>
            <ecNumber evidence="13">1.11.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxiredoxin-like 2B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110985701</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>prostaglandin H2 + [thioredoxin]-dithiol = prostaglandin F2alpha + [thioredoxin]-disulfide</text>
            <dbReference type="Rhea" id="RHEA:28214"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57404"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="EC" id="1.11.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>prostamide F2alpha + [thioredoxin]-disulfide = prostamide H2 + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:26373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:53081"/>
            <dbReference type="ChEBI" id="CHEBI:53082"/>
            <dbReference type="EC" id="1.11.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peroxiredoxin-like PRXL2 family. Prostamide/prostaglandin F synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.20" evidence="13"/>
    <dbReference type="RefSeq" id="XP_022102605.1">
        <property type="nucleotide sequence ID" value="XM_022246913.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985701"/>
    <dbReference type="KEGG" id="aplc:110985701"/>
    <dbReference type="OMA" id="QRPVCND"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047017">
        <property type="term" value="F:prostaglandin F synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000243">
        <property type="entry name" value="Prostamide/prostaglandin F synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF29">
        <property type="entry name" value="PROSTAMIDE_PROSTAGLANDIN F SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022102605.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="22610" checksum="040D8D6490D46D87" modified="2022-01-19" version="1">MENAGFLSKIAGNLVKSAASGEMVTVGSFWKTQTCVIHFMRRFGXPLCRLGAKELSLLKPQLDAHNIRLVGVGLEEFGLEEFVEGKYWDGELYVDLKKQTYADIGYKRFSYWNILAAVFSKKAREALAKSKAAGITGNMKGDGLGTGGTLIVSKEGKEVLLNFKQSSPGDHVPLADVLKALGIDEPVPIMETSKSAEENKGDAAEGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCQ2</accession>
    <name>A0A8B7ZCQ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Polycystin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110986117</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polycystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103453.1">
        <property type="nucleotide sequence ID" value="XM_022247761.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986117"/>
    <dbReference type="KEGG" id="aplc:110986117"/>
    <dbReference type="OMA" id="NCATQNA"/>
    <dbReference type="OrthoDB" id="444119at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00146">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000086">
        <property type="entry name" value="Polycystic kidney disease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000022">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002859">
        <property type="entry name" value="PKD/REJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013122">
        <property type="entry name" value="PKD1_2_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003915">
        <property type="entry name" value="PKD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046791">
        <property type="entry name" value="Polycystin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014010">
        <property type="entry name" value="REJ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00801">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18911">
        <property type="entry name" value="PKD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08016">
        <property type="entry name" value="PKD_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20519">
        <property type="entry name" value="Polycystin_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02010">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01433">
        <property type="entry name" value="POLYCYSTIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="PKD domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51111">
        <property type="entry name" value="REJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2005"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2212"/>
            <end position="2233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2257"/>
            <end position="2278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2354"/>
            <end position="2377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2397"/>
            <end position="2420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2493"/>
            <end position="2511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2760"/>
            <end position="2784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2796"/>
            <end position="2817"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2849"/>
            <end position="2868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2889"/>
            <end position="2911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="2948"/>
            <end position="2973"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="17">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="17">
        <location>
            <begin position="247"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="17">
        <location>
            <begin position="344"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="17">
        <location>
            <begin position="431"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="17">
        <location>
            <begin position="717"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="17">
        <location>
            <begin position="818"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="17">
        <location>
            <begin position="917"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="REJ" evidence="20">
        <location>
            <begin position="994"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="19">
        <location>
            <begin position="1821"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="18">
        <location>
            <begin position="2050"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2452"/>
            <end position="2472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="3062"/>
            <end position="3087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="3067"/>
            <end position="3084"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="2606"/>
            <end position="2619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR603915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022103453.1"/>
        </source>
    </evidence>
    <sequence length="3097" mass="343256" checksum="C5ECAAF79600B68C" modified="2022-01-19" version="1">MTFFLSIPVYGIFVVEVNVSNAMNSVTLNVPVQIGQEIQGFYAKVPFPVHATGDNISVEFGFTAGSEVVFEVDFGETHQFNFETNSVANKTIYHQYNSPGDFTITVRAHGALGDKVRQFPVRILNAINGLRMETSSTSLETGKPVLFTFYLVKETAIPQIVHCDINYGDSSKTDSWDGVLSDDNITLEHIYVTPGSRQIQANCSNEVSQVMLSVNVTLYIPQTGCFISVDPMMTTTNTTVHYVASVSNGSDVNVLIHFGDGTNMSAYSDSTGYVVFEHIYHLAGSYAVQMKASNPVSDCLAYNTIVIQIPIHTDSYNLSITPSLVDISNQTTVFTISLMDDEIPTNVTAYWTFGDGNSSTQFLYSGVKWSISHIFEETGEYEVLVHLSNMISELNFNSTVVVMEHIDALEFNISNAAAVGDNLTLSLLATSGSSIFYYIDFGDGTADMLFQDKPEILHLGHSYDQVGWYILTITAENGLGGVIHNRTKIRVVYPVQGLNFEASSAVIYSPGNITFSLTIDEVVPPPTVMDCEWRRQPAGQASLGDDILLRERNVSIGTGESLNVTHHFPGGQFTVILHCRNILGGVTLKEEVTIYEGISELKMSSDSLIAEVGSQVQITVTTSQGSLLNYAVKYGDGTTDNRLVVMSRSTKIQEFLHVYARPGLYIPSVHVVNFLGESSANLNASVDVLPSTRGFQLLANSPTFPNTLVVFTLVAIQGTTPPSMIQLIWNFGDGSIDFESVEFNTTQGINRTHLYNSSGMYHAEVTVTNKLDSHIFGTAVTIIPKVEPIKVRFDYKNKDGIWTVGLGHNFNWFPTDTDVRMIANTTSNDASIIWEFDNGETALLQIVYKRYKNPGVYTATLRVTDSMGKLEEFHFIFYIAKPFILLSIQAVDATGLPSLKSGNQVDFTLIGDDLQGPVCISWNVGDQTQQYVYGPSSCRMPVHDDVIFDQANRRVGLHISHTFTSPGNYHVYVSASNFFTTASISTIITVTGCKSPPQVSIRGPGETVDAPRSYRTSEAIFLDLVTTFDCIGAISITFNWEVNKLIADDVQNITQKVGYTVPFLNRPQLELPAGSLEVGLYEVSINVTVERFDNATGSDKVFIRIEHSPLVLSLEGGSSRSVGNIAPLVLDAMTSSYDPDNTAGNSSDWSFKWSCRKISDDHKNNSITTNLDDYLCDNSSWEQMNFTKAIIQLNPLQLRVDAVYVFKVETTIGSRFASYQQTIQVMQGEPPKVSISCVSNCRDKVNPTSSFTLQGSCSNCDANSQSLFTWTLYSKQQDSEDLQHVSNLGNMTSTGVSKQGIAFNPSELDAGREYYLRLDVKDVLLGNGFTQYSFLTNLPPYNGACQINPSVGFAVTTEFSINCSGWLDEGHAINRDSISQHLASGQVLQYRVMSRAKGQTDFSLLTSSADSSTSGILFGVGPEEFSFQHDVQVAVVDVYGAAASVNLTVSVRKPDLTADAITSLVGSNNSRLSLLASSGDVEGATQLISAVLTVLSEPQDENSTFTPEELRELRSNLILELSKVSLWAKTANSLFQASVVMAMSLTGGVNDNALVEAAAAMAGMALSLKGIDEDNPEVVIDTAKGLTDGLGSLIAQSDKIVQTVMGASEASVSTTTSPSGTGELVVFDVYGDDLSPEELAEEAMRKKKERERNEQNAREVASTISMLAQGTLDLVSDVVIGQRVTGQPPVTLVTDQLTLEVFKDEPISVANRQINTDAGSFSLPNASSLFGSSGAKQVEQFIFSYNANPYSFSKSSDSIGSKGVLALDFKTGQGELLSVQNLTDMISIALDVDQSKLTSAETVRMTFMNASTMQYHKVEVQEENIQLRVIFREMTDNVTKFLVYLRKGSRPDTRSYDALIEIPRNLGEDEMWSDVGLVTEARHTAVFSEELLTGVGDYYLGVGLADTSDLHQDSSNGTTLIVNQTDEMFEVNTTMVIYAAGCRFWDTNITAWSSRGCQVGSQTSTSSIHCLCNHLSSFASSFFVPPNTIDFSTVFSKFQDLGSNVAVFATVLGFFGLYLLLLIWLRRKDKQDIVKWGVSPLGDNHPNDTYFYQVTVQTGMGPGCGTRSKVSIILTGEDGDSGVRLLDDDKRKVFESGSICHFLMGVARPLGPLSYIKLWHDNSGHGQLAGWYLSQVSILDLQNGQQYFFVCDRWLAVEKDDGAVERVLPVATRSDLTQFSKLFFSSSRRNLFDDHIWFSLFSRPTRSPFTRVQRLSCCLCLLYLSMITSAMFYRTEETVENPTALRLGPFIFTLQELYIGFISALIVLPVNILIVQIFRKSKPSKSQMTNSLPKHLQEKLNHLRDSASESSTPQSSLVDVKSSDKIELVPADAPAKSKTKIGKAKTKPFLLPHWCVYIAWLLMILSSFTAAFFTILYSLEWGQQKSSEWLTSMLISLVNSVLVIQPFKVLIVAMLLSLIFKKPAKMDVEMDADLSCDQNQLRDDEEILHQSLSPGKLNSPEHRQRLPPSKEALEEARQKRIKEIKLNRTLKETGIYTLFVVVVLFLCYSSRDGMSFYMSQSLRDIFVDNTGTKNTSAKVSFKSLEKSTPDLFWQWVEEALIPGLYGNTYYNGVPMHWRHTRFIADWQGYRVGPVRLRQLRVKDEPCALHPDISMLHATCHLDYSSGNQEESNFTVAWQLKDTPNLRLYSEEERAPWIYQDFLELNGVPHPGRLAVYSGGGYIAEFGTTTAEALATAHFLRETGWYDKLTRAIFVEFSVYNANINLFSVATLLAETSSTGGALVTSHIHTLRLYHYEGAIAIFNIIFQVIFVAYLLFFIIKLILLIKKAGLKELKNFWTALELILLLVAIVAVIMFAFREVFIKLALQEVKNKKQGRFVNFGHIAKWDELFGYLLACLSFLSLIRYMHLLRLNARMSLLGMTLRHASRDILHFLIMWSLVFCAFAQLSYLLFHGVVEMFSSFVATLETLFSMLLGKFDFNALVEANRWLGGAVFLIYIVTMYLILTNMFITIIVEAFNHMRHQEGLNEVIDPEIVEYIVERFKAFFLRPVQGTKATSQVTAKLMYEDTMDLLEKSVDKIINFVETNYGKVDVTANQSETLGSPARSLSRISLHSATRSSDNGSKPNNKKACNRVIFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDU1</accession>
    <name>A0A8B7ZDU1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitogen-activated protein kinase kinase kinase 20-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110985878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103005.1">
        <property type="nucleotide sequence ID" value="XM_022247313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDU1"/>
    <dbReference type="GeneID" id="110985878"/>
    <dbReference type="KEGG" id="aplc:110985878"/>
    <dbReference type="OMA" id="CPEHQQM"/>
    <dbReference type="OrthoDB" id="10013149at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="27"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103005.1"/>
        </source>
    </evidence>
    <sequence length="313" mass="36068" checksum="41E59A1984122C32" modified="2022-01-19" version="1">MELANDQNQKMETSVSNYNIIDLKDISFDAEISTTGSRNKVYRATWQKSSRKQKVAAKCCQRFHEEEVLILARMNHDNIIKFLGVVKPTSVLENYFIVTEYAEGGSLYDVISQHREDWPEFRQSRWMRWAQDGAKALQYIHEKKYQHGDVKSPNFLVTSDETLKICDFGISRQCDYTISTVTNRGSSPWMAPEAFGDVMYDSSSTKKPCKVTTKSDVYSFGVVMWELISGEAPYSNKMPMQILTAVVINKKRLEIPHDCPEHQQMSDLLNKCWQADYTQRPSIQEVLQSLIDIDNGCKKILGKRRQDTEEDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEY2</accession>
    <name>A0A8B7ZEY2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104194.1">
        <property type="nucleotide sequence ID" value="XM_022248502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEY2"/>
    <dbReference type="GeneID" id="110986553"/>
    <dbReference type="KEGG" id="aplc:110986553"/>
    <dbReference type="OMA" id="KQFCCNG"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022104194.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12949" checksum="7ADA7448D4FFC517" modified="2022-01-19" version="1">MDAEISIENLRMTSACDDFQDSNEDGTMNLVHVRCQQRNGRKMITTVEGIPHIYSQTRLVKKMKKFFNCNGNVNNEKDFGEVIQLQGDQRKNVKDFLVKIGLAKDSQVKLHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFF9</accession>
    <name>A0A8B7ZFF9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC110985320</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110985320</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101960.1">
        <property type="nucleotide sequence ID" value="XM_022246268.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101961.1">
        <property type="nucleotide sequence ID" value="XM_022246269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFF9"/>
    <dbReference type="GeneID" id="110985320"/>
    <dbReference type="KEGG" id="aplc:110985320"/>
    <dbReference type="OMA" id="CTICCTR"/>
    <dbReference type="OrthoDB" id="9987040at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022101961.1"/>
        </source>
    </evidence>
    <sequence length="658" mass="74299" checksum="46070EECA5C314C5" modified="2022-01-19" version="1">MSTELLHGPLIMANLLTRGHVPAIKCEACSEGNRAIARCLTCDDFICGHCKQMHERWAILKWHQIRTLAQLRSGEVSDAGKLQGNALKCGEHPEESIHFYCVICEQLLCTICCTRHQKFSKQSIVSLLDPEVRCKQGIVGLVSKLQVAVAELDKARTEQDKWYGRLQAKFDEIKRKVSQRADKEVERVPDKVEQIRKEKDNLIQDLNNIYQDKVEELKAAKITIKKEADQLQSMSDEINCLDSKADSHMLLVLKHKLDGKLVELMAKQHMRVPEKESFVTFEESERCGSVGRLILDDEVKLQPFTSVKSSRTARHRKHTHKEFWDFTTFQKPKEREKTQSSILSSLPSAVAKEIESHNSKVADLRLQEEPQHQSPVELLRQRPEESWKLTTDLKTFGPNQTEFAFVNYVAAFAKDKIVAVDFGQRELISFSPNCNSPTPNIPQKLSLPDSIKASNVAGNKNDFLVILDGLSVKVFDKHCQLLHQFTPSVGKDSTRSCLIVDDDNVIAVGYRYKEQLSFHTLDGSHIKTIQTPMIWNYLTVCQQRLIYTNYKRKKLLVVSYNGVLVISLDIIGDFQGQWGPTGVCCDSEGSIYVAVETGGTFAEIRKYSADAAYLGCVTIDCRLPRGITFTTGGELVIAAKHSVKIFRCSGRSKPLTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIC6</accession>
    <name>A0A8B7ZIC6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105314.1">
        <property type="nucleotide sequence ID" value="XM_022249622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIC6"/>
    <dbReference type="GeneID" id="110987148"/>
    <dbReference type="KEGG" id="aplc:110987148"/>
    <dbReference type="OMA" id="WLTIRRS"/>
    <dbReference type="OrthoDB" id="10031171at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105314.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="44474" checksum="AD4B8F662FEB5DBC" modified="2022-01-19" version="1">MYLCTMAEGLGPVPLPKNKSKNRSLGWLTIRRSRSKNKYNLQNAVPHACQHPDDRSGQDSLGYVDEDDIPKLVERLRMLESEQTPCDPEIVITTQKHLIDALRRENGALRLLRHQVELLRRENTKLKKEAEKARPKKLANGAKVKNGVPNGDISETDMLEDKDEDSGDIATLKLENERLRKSNDQLQNCLDEHKRQTNELTNGEADGHEASNGIAKEGGTNGQSGRQSPRNAGENGKKSRPVLMKGNDNGAGTSGTSLVSVNCLRKSDGNFHDCDEILEERLKSHMAAKGVDLVFKEWSPGRDHHMVTLVFCLASNDVAQNIAKALDGVSSDAEVILVVFHTASQESTRKDPETESLNLSSLSNACLVVDVFFSKRDSLYRCNQNNRAMSRLLHLFEVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZII6</accession>
    <name>A0A8B7ZII6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM161B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM161 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104827.1">
        <property type="nucleotide sequence ID" value="XM_022249135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZII6"/>
    <dbReference type="GeneID" id="110986868"/>
    <dbReference type="KEGG" id="aplc:110986868"/>
    <dbReference type="OMA" id="RENRWPY"/>
    <dbReference type="OrthoDB" id="2150121at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051655">
        <property type="entry name" value="FAM161"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019579">
        <property type="entry name" value="FAM161A/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21501:SF1">
        <property type="entry name" value="PROTEIN FAM-161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10595">
        <property type="entry name" value="FAM161A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="199"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="387"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="472"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="571"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="736"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022104827.1"/>
        </source>
    </evidence>
    <sequence length="814" mass="94165" checksum="05C4283796274F01" modified="2022-01-19" version="1">MATALGGHSLSALTNSCVKLPINPRSRLAATFTERGGSFKPYSEKRTEDEERELVNDTAPNGIRYGYGDVRNLDNGHDYSDGHDGGQREPVNQDEHSRLQPDQLFESLKDNIDSYTDEEFYRKLTEMKDEHRKTLHRLEVLYDQKLTLNGHDVPGSNIEVEEPPFTKSGPVYIGDHKLCHIDDEIEQFTKSHDWSAKKDHVKDMSAKPPIGRPKTAWAGKSRRSLRRSMPTENWSDITWNSDSGQDTSGSELDVSNMSTQSRRTQNLSKPYSTSQDMVDRMWDDFSVEEYAPRVRSSSRASSVRSTGSVKSKEWSPKITIPKPFQMTQREATKEKTKSRACLELEQELAEKEKAEEAECQRKFKATPAPVHTFMPLYDEIQERDIERSRNNRENSKTRLLSQQRPFSFVKREEEKKKHRRSQSLPLTEAKGKKPKQFKAKEIPKSVFDPTVSDRILEEEEYRKIRIKMRSEEMLRQSSLPPNMQHRGKEYTDGKMRQKLFKSREKMAFLTTEHKFRPQVNGEVPDYDELYRQFQQEVQRKKREKEPTVVQPFNLRTARIPSKMNKILDEMKQEEEKRKEKLRGSSSKSLSLRSSLNISEDVIPAKTTAASKMRKSVTERALREKAEKEREEAERERQKRIKDRKLKQFITRKALANDNSESLSVSSKTKLQNYIQAGKSRQAEYEQQLKEMMSRVESRPLLFERQSQVNAKKAAEKKYQQALQDAGLDEEFLVRKGRGSITQASMRSYDYPDDSDEDLTFGRQDDVDVSLGSAKGGMGSHQEGGSHSYDNDFDDEEDDDENRSISSIHSEEAEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJQ8</accession>
    <name>A0A8B7ZJQ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987028</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105115.1">
        <property type="nucleotide sequence ID" value="XM_022249423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJQ8"/>
    <dbReference type="GeneID" id="110987028"/>
    <dbReference type="KEGG" id="aplc:110987028"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105115.1"/>
        </source>
    </evidence>
    <sequence length="209" mass="23205" checksum="36605761D9F39182" modified="2022-01-19" version="1">MIGSEICERSTMKNDLVPAQPQPPPAGEDGYWGAIWGSIARILTYLTGNNPFVEVLILISQVCANLVQRFRRAPAAPDVIDGPEQQEDGPTRRENRGTRNRRRKNRRRNAPDGTDEPDTTYPASHVADGKGVVRIKRLVNDGDCNPVVMDAQACRVNYVTNQGQVQEQRAMDPGKLTGANRLEIDEVKLSGKNSPFMLSASHCDFNYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLB1</accession>
    <name>A0A8B7ZLB1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110987717</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110987717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the apolipoprotein L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106403.1">
        <property type="nucleotide sequence ID" value="XM_022250711.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106404.1">
        <property type="nucleotide sequence ID" value="XM_022250712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLB1"/>
    <dbReference type="GeneID" id="110987717"/>
    <dbReference type="KEGG" id="aplc:110987717"/>
    <dbReference type="OMA" id="EMKECVF"/>
    <dbReference type="OrthoDB" id="10429286at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042157">
        <property type="term" value="P:lipoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008405">
        <property type="entry name" value="ApoL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096">
        <property type="entry name" value="APOLIPOPROTEIN L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14096:SF28">
        <property type="entry name" value="APOLIPOPROTEIN L, 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05461">
        <property type="entry name" value="ApoL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022106404.1"/>
        </source>
    </evidence>
    <sequence length="279" mass="29246" checksum="02536FF7F768FB90" modified="2022-01-19" version="1">MSALMEPYMEEYSYDMDIELQLSFQLQSLDDAAMEFVRCRQNTVKVLRDLVAYLTEHHTNAQVAKIVGSTVGLIGSALTIGGFIAAFFTFGASLAVSAVGAGIGAAGGLTTVGGVATEAITSRITEQGVKKALEDDNAAYQKFLEAMGRLKSTWEGMRATVMGVRSATVVGHGLGVVGGIAEAGAQAASVGRAAGQAAFKTASAAGRGLAITGIVFSVVAIPIDLYTLITSAEKIGKKTAPELAKEISKIVEELPCPSEDEMKECVFKLRTEYCADTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLD7</accession>
    <name>A0A8B7ZLD7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DNA repair protein complementing XP-A cells-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987439</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105867.1">
        <property type="nucleotide sequence ID" value="XM_022250175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLD7"/>
    <dbReference type="GeneID" id="110987439"/>
    <dbReference type="KEGG" id="aplc:110987439"/>
    <dbReference type="CTD" id="7507"/>
    <dbReference type="OMA" id="TCGHELS"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21076">
        <property type="entry name" value="DBD_XPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000001">
        <property type="entry name" value="DNA repair protein complementing XP-A cells"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022652">
        <property type="entry name" value="Znf_XPA_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01286">
        <property type="entry name" value="XPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022105867.1"/>
        </source>
    </evidence>
    <sequence length="263" mass="30293" checksum="FFCEEFAE3A9D6394" modified="2022-01-19" version="1">MSGIEAKPTLTDAQRAKIEKNRQRALLLRQARLSSRPYPQTKPSDRTEKAASSGRVIDTGAGFLLEEEPEEDESSQVKIVHEPGPLLGGAPSVCVECNKGFQDSYIYSHFEYEVCDECRDSEGKHSLMTKTDAKQSYLLKDADLERREPVLKFIVRKNPHNPRWGDMKLYLALQVEKRALEVWGSMEKIEQEKEQREANKEKAKQKQFDKKVKNLRRAVRSSLWTKDTQSHTHTYGPEVYDEDSDMYSKTCTSCQHTLSYEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLU6</accession>
    <name>A0A8B7ZLU6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">La-related protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110987441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105865.1">
        <property type="nucleotide sequence ID" value="XM_022250173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLU6"/>
    <dbReference type="GeneID" id="110987441"/>
    <dbReference type="KEGG" id="aplc:110987441"/>
    <dbReference type="CTD" id="55323"/>
    <dbReference type="OMA" id="WIGGLWR"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08033">
        <property type="entry name" value="LARP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12289">
        <property type="entry name" value="RRM_LARP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000158">
        <property type="entry name" value="La ribonucleoprotein domain family member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034880">
        <property type="entry name" value="LARP6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="7">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="209"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="8">
        <location>
            <begin position="458"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022105865.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="56804" checksum="BC6FA3CD7975FAAD" modified="2022-01-19" version="1">MSESAALETTENGTDGLASQQLATGDGQTTTPSAEPNSPSAPGLSTSPVTIHIPPLVQISSPPEPEPSGDDAGGDTSSGSLSDGRNTPGKERSNTMNESRSDGRGGENAEWTPPDEELKNRIIKQVEFYFSDANITKDAFLLKHVRRNKEGFVSLKLITSFKKVKSLSKDWRTVRYSLKSSTTLEVNEEGTKVKRKAPLPDYDETSPSRTVVAVNLPTENPSIESIAELFSKCGEISLIRILRPGKPFPPDVRKHIERHSEVRNKVCALIEFESGQSALKAAKVMSDKDNWRTGMSVTVLAKEKKEKKQSQEKTSNRKSAEGLSPSQAGDLTASDGGEGGDSAKKKKRQRKKKNARVEELSAERVEQSGTPSSSDTENSPLPSRRHASKAGPVPQSKSPAHLSPSNTPKSSPNPSPHGSPRQQRKVVGRSPLANSRSSPRASPEMGRKVYDSFSDHSNTSSPWVQRRKLLAASAPEGSPAGSPLLGRKNLMHNNEHESILRSPFGPDGTRGFSIGRGRGRPKSVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLZ2</accession>
    <name>A0A8B7ZLZ2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TBC1 domain family member 8B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987474</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105915.1">
        <property type="nucleotide sequence ID" value="XM_022250223.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987474"/>
    <dbReference type="OMA" id="HMCFYAY"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003094">
        <property type="term" value="P:glomerular filtration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13351">
        <property type="entry name" value="PH-GRAM1_TCB1D9_TCB1D9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13354">
        <property type="entry name" value="PH-GRAM2_TCB1D9_TCB1D9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000013">
        <property type="entry name" value="Putative TBC1 domain family member 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000023">
        <property type="entry name" value="TBC1 domain family member 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000041">
        <property type="entry name" value="TBC1 domain family member 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036014">
        <property type="entry name" value="TCB1D9/TCB1D9B_PH-GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036017">
        <property type="entry name" value="TCB1D9/TCB1D9B_PH-GRAM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666:SF1">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="9">
        <location>
            <begin position="564"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="931"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1199"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1321"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="994"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1112"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1202"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00067411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105915.1"/>
        </source>
    </evidence>
    <sequence length="1411" mass="159221" checksum="39082E19D0D8D614" modified="2022-01-19" version="1">MWVRPEEVLLANALWITERANPYFVLQRRKGHGGGGLTSLFIGTLDSVLDSKALPYRILHQTPSSEVSYTVATAVHKREIFVHWEWLEQNLMETLGTFEAEEDITEFVKCKIESLVAVIETADEGPKEVDEESKAFKSACEKWHRLFKVPEDEKLVNYYSCSYWKGKVPRQGWMYLSVNHLYFYSFLMGTEARLSIRWTDVTHLEKSNAVIFPESIKLSTRDQDYYFSMFVRPIETFSLMEQLANLAMRQLLSEEGFEQDKDLPPITKISKKKKKVSSLKRDLDARLRSEAYRQVFRLPTSEKLDGHVPCTLWTPYNKTHVNGILYLSRNYMCFASRLKNLVYVVIPMREVTVIEKVENSSVIQNGLHVSTRSKMTILFASLKDRDFLVSHIADFLSKTTENTRHRSDSLSVSSSSSTSLIEMPANHRPLAQISSSLGSLGSTGSNASIKSDHMSYYNTVLSDDLVNTNITDSPLSLSPCLPTNKYLCLNPAIEMFPDEGNDPSGSIAVQLQPALLTLFNRRHSDQVSIKESVKMHLWDIHFKEFGRGVCMYRTVETQELIIKGIPESLRGEIWLLFSGAINEMATQAGYYQSLVEQSLGKESIATDEIERDLHRSLPEHPAFQSELGIAALRRVLTAYAYRNPSIGYCQAMNIVTSVLLLYANEEEAFWLLTAICERLLPDYYNMRVVGALIDQGVFEDLTKEYLPELYIKMDKLGILSMISLSWFLTIFISVMPFESAVNIMDCFFYDGARFIFQIALAVLDANQDALMKCEDDGTAMTVLTTYLESVQNKDATAPSMPHTSTLTAMTIERKPDIDVSDLIHTAYAKYGYIRTDQIKKMRLNQRLRVVQGLEDTARRTVVRSLVGEVPFNMEELEDLYTIFKEEYLTSNMLSGAPVLDQTQHFLATFKIDLEKFRTLFLTFSPWACGTQADLLALRAFRLLDEDRDNLINFREFSWGLGVMCRSELPERLRLLYRLHLPPALLPEDMESIAGDSQTDEASTVGQPSPDEDQDEVEPAVDAEEYFESSMKTPTVEQAPGGHPLSQSTSESQEKSEQTPKHTPGQSPSDSPKKAPPEENKSEDEESQVHGRGDVFDPTGDELQTVLLEGEQPQEKDSIDAEREGYRYYLRKWEREQEEKERQKSFKHLPRINQDQFIQLLKTLYDMFVDHPREQELYRAIATVGSLLFELGEVGKKFKRITPTGSKPTESSDGGESSEVTGRSEVSEMLVAAGPVPGLTELRGDKSSDIRVGDAMIDDVSKVEDGTSASSAETDLRVEGDSLEMELADAMRDIHVTPEGDTMDATQPKDLLLISKDGGIPHRGNAGAGDSPGQVKASPCRPKTLPCPVSGASKSEPAWEVTFEQLLASMLTESAIVEFFEERPDILRLAEGFRQGRSLQRQTSDISMSGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM10</accession>
    <name>A0A8B7ZM10_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450 3A24-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987849</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106653.1">
        <property type="nucleotide sequence ID" value="XM_022250961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM10"/>
    <dbReference type="GeneID" id="110987849"/>
    <dbReference type="KEGG" id="aplc:110987849"/>
    <dbReference type="OMA" id="EIFSMCM"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF15">
        <property type="entry name" value="FATTY-ACID PEROXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022106653.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="57605" checksum="A3557D34C9FC3672" modified="2022-01-19" version="1">MIGTIIIVLLSTLLVYLSWRTYDQLTFFSKLGLKGPTPVPIFGNLFGFKDGVHIAIGKWIKEYGKTFGISRGAQKVIVTSDVEFVKEVMVKQFSHFVDRQGFPLRPNEMCYDLLDLKGERWRTMRETCSLAFSKHKTERMLSMVNECADTTIKDIQEHGKNTNGVLDIHKYMAEFGIDVGAYCFFASKVTAEQEKFVLMQHAYALWIRFKTVYVPWLLTVLFPKLEPLLKLLGCSIHPQTSVDYFTSLMKAIMDTRKSDPNAQEYVDFLQLMLNSEKGLEIKASNGQSIQKRALTDNEIFSMCMTVFTGNMETSPGTLAYAFFALALHPEVQERVIEEIDRVTADGITPENVRKLAYTDMVLREVLRLYPTVASLNRVCLEDCVVKGIKIPKDTLVEIAVYAIHCDPENWPDPYRFDPERFSAENKAKMDPMTWLAFGQGPRMCLGYRFAMMEMMVIMVRMLKKYRLETCAETEIPPSRGVRGLMSPEHGIKIRLVPRQKQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP58</accession>
    <name>A0A8B7ZP58_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Uncharacterized aarF domain-containing protein kinase 5-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC110987968</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106840.1">
        <property type="nucleotide sequence ID" value="XM_022251148.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106842.1">
        <property type="nucleotide sequence ID" value="XM_022251150.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106843.1">
        <property type="nucleotide sequence ID" value="XM_022251151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP58"/>
    <dbReference type="GeneID" id="110987968"/>
    <dbReference type="KEGG" id="aplc:110987968"/>
    <dbReference type="CTD" id="203054"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF28">
        <property type="entry name" value="AARF DOMAIN CONTAINING KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="184"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022106840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022106842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022106843.1"/>
        </source>
    </evidence>
    <sequence length="607" mass="69432" checksum="D2CE190FCA107F87" modified="2022-01-19" version="1">MARLVHLDILERCRPAFSQIVGCKLRMKAHDGARINLVKVHNVLVKHQSTAPAIGKAVRSRWRIVRRTLAGILLLAPMAGLGAYAALDSTSRRKVYVTAQGFVRFFRTFYIGSCISLDYKWSLWNLEEGSEEYKKAFRACNERTGDMIVRGCLKNGGMYIKLGQVLVTANYVLPKEILLKLSVLHDKALSREYKELDQLFQEDFNCKPDEMFKEFDPKPIAAASLAQVHRAVTHDDQEVAVKVQYINLRDQYSGDFKTLQIMLDLVHWMHPNTINYNEILSDMEAPLAKELDFENEGRNSERCASNLQHLKYIYVPKVHWNLTSKRVLTMEYIDGCKVTDIDQIEEMGITPADVDAKLIEAFGEQIFRTGFVHADPHPGNIFVRRASNGKAELVLLDHGLYEELPAKVRLALGRFWRSVILKDEPIMKQSAADMGVKEYLLFGMMITQRPINMKARRGLHMTFIVPPEELRKMAEQFHKMSQSQAEMMMARLNDFVLSLPKSLYLILRNMNTVRSIDRTFGQPVNYLVTMGRCAAGSMFFESQDRTLAGRVRASWYQFIYDFTLRSDQVLNSLTSFIMRVMLRLGWKVPTKPAGSAHGIMDSLQPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPT9</accession>
    <name>A0A8B7ZPT9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110988003</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110988003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106920.1">
        <property type="nucleotide sequence ID" value="XM_022251228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPT9"/>
    <dbReference type="GeneID" id="110988003"/>
    <dbReference type="KEGG" id="aplc:110988003"/>
    <dbReference type="OrthoDB" id="6819125at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF15">
        <property type="entry name" value="LYSINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="4">
        <location>
            <begin position="61"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022106920.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28686" checksum="FC2C5759012E3838" modified="2022-01-19" version="1">MAIKLILSKTRELSLHLNQAVLLAKSLLPLPNKFQGVKDIELRYRKRYLDLIINPEVKKTFALRTQIISTIRHFLDQHNYLEVTTPILHSVLSGAAAKPFKTQHLALKIPLYLRVAPELYLKRLIVGGIAQVYELGRVFRNEGISYQHNPEFTILEVYQAYGNMETMMNLTESLILHIAKKQEKRLLQQLKEHKLGNEEANEMDPDFIEALSYGMPPTGGLGIGIDRLIMFFTNSSSIKDVIFFPTLKPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZS23</accession>
    <name>A0A8B7ZS23_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Hormone-sensitive lipase</fullName>
            <ecNumber evidence="11">3.1.1.23</ecNumber>
            <ecNumber evidence="10">3.1.1.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Monoacylglycerol lipase LIPE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Retinyl ester hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="45" type="primary">LOC110988815</name>
    </gene>
    <organism evidence="44 45">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="45" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O</text>
            <dbReference type="Rhea" id="RHEA:38379"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="33">
            <dbReference type="Rhea" id="RHEA:38381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1,2-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38455"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:75937"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:38456"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,2-di-(9Z-octadecenoyl)-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38659"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:38660"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39935"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:75937"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:39936"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 1-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39939"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:39940"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38487"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:38488"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1-O-hexadecyl-2-acetyl-sn-glycerol + H2O = 1-O-hexadecyl-sn-glycerol + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38563"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:34115"/>
            <dbReference type="ChEBI" id="CHEBI:75936"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:38564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38383"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:38384"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:52392"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:26133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>2-(9Z-octadecenoyl)-glycerol + H2O = glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38491"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:38492"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolyzes glycerol monoesters of long-chain fatty acids.</text>
            <dbReference type="EC" id="3.1.1.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.79"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.79"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.79"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13933"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17616"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:13934"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33875"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:46898"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:33876"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Glycerolipid metabolism; triacylglycerol degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="26">Monomer and homodimer. Interacts with CAVIN1 in the adipocyte cytoplasm. Interacts with PLIN5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <location evidence="4">Caveola</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.23" evidence="11"/>
    <dbReference type="EC" id="3.1.1.79" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022108373.1">
        <property type="nucleotide sequence ID" value="XM_022252681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZS23"/>
    <dbReference type="GeneID" id="110988815"/>
    <dbReference type="KEGG" id="aplc:110988815"/>
    <dbReference type="OMA" id="FAACQDH"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="UniPathway" id="UPA00256"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010468">
        <property type="entry name" value="HSL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06350">
        <property type="entry name" value="HSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="16" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="44" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="21" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Hormone-sensitive lipase N-terminal" evidence="42">
        <location>
            <begin position="30"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="43">
        <location>
            <begin position="368"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="43">
        <location>
            <begin position="736"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="41">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="41">
        <location>
            <begin position="534"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="41">
        <location>
            <begin position="624"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="41">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="41">
        <location>
            <begin position="536"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="41">
        <location>
            <begin position="677"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00013088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00013254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00015845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00030031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00031112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00046695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00047458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00047476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00047653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00047674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00048386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00049053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00049143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00049208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00049372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00049461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00049519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="42">
        <source>
            <dbReference type="Pfam" id="PF06350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="43">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="RefSeq" id="XP_022108373.1"/>
        </source>
    </evidence>
    <sequence length="841" mass="92393" checksum="2542285A25F3B655" modified="2022-01-19" version="1">MEARSGSETSSGTADQKDTENLPCPVLMSIKTLRQLVINNIEHYQKSKSSSGEKFFTVFCLIEQESDAVRPAVETLAAIAPRFDYDELTPGNGYRSLIGVVDCCVEKLIQISRYIAVNRDSLLFRAGHYLRELEAYSKVLSQLRVLLSYGEKLLAYSEVDKCQLFPEKDQLEQMPQDIMLEVQALDRECFYGRCLGFQFCDSIWQSLQTVAVALASYSEGYHKHEGTFSRAASSIFHGSRYLTNPEARAKQIVNVTNKSDIKFCKAFWSITEGDVIAEMCNLMAGSVAINKLIQIQPHTFELDGEDGEPVTIVPPCAHTGPGNVQIRLLSFVERDGQGWLHDVSPQGKSKGKEEIPPKSVAPISKGMLIHIHGGGFVAHTSKSHEIYLRSWARDLGVPIVSIDYSLAPEQPFPRAFEECFFAYAWALKNAQFLGSTGEHICLAGDSAGGNLSVAVAMRAASYGIRAPDGVVALYTPFNVHYQPSPSRMLSLLDPLLPIGILIRCLAAYAGLEEEFISQEVANAIVQKANDKFQVATSGKSSRGSSVRSTDSCSSQDAHQSQNVDEKPKASDADADSNTQSRSEEDEDAFLRTLEMTDAWSPDVDEGELKLPDSGIGVAISKMEKHESVTPNGNVPHGEPLDEPEPIAVVDPSVPLGSPSQRSKVIHQPKDSDGMTGDQKSTTNAVLPDNNNMTPTLKRESLTLDLGEEPVVKRGPETPSAYVTSPIRRLREVPIMKNSYMSPLFATDELLKGLPQVHIIGCTFDPLLDDSIMFARRLRSLGCPVQLEIIDKLPHGFLLFSPVGKESKAASMVCVKHIMKVLYGFDAKEEDEEFSELGSEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZVJ9</accession>
    <name>A0A8B7ZVJ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Gamma-interferon-inducible lysosomal thiol reductase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110989391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109444.1">
        <property type="nucleotide sequence ID" value="XM_022253752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZVJ9"/>
    <dbReference type="GeneID" id="110989391"/>
    <dbReference type="KEGG" id="aplc:110989391"/>
    <dbReference type="OMA" id="NSAKACT"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003119">
        <property type="entry name" value="SAP_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02199">
        <property type="entry name" value="SapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51110">
        <property type="entry name" value="SAP_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034614673" evidence="8">
        <location>
            <begin position="23"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Saposin A-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022109444.1"/>
        </source>
    </evidence>
    <sequence length="253" mass="28668" checksum="A278114EDA5C2CA3" modified="2022-01-19" version="1">MMGYRSTVAVLLVVFATQSARGMSCTFPPELWCSSSEIAESCHVVKQCSEWQSPVKDAPKVNFTLYYESYCPDCQLFISGQLHDAYMAVSEIMNLTMVPYGNAEEKREGSKYVFQCQHGQEECRGNVLETCILHFAPFQTAFQTIYCMEVSRDPVTYARECMEKMKVNPEQVFACANGSLGNALEHQMALKTDALKPPHQYVPWVTLNGVHTEKIQNEAEMNLKKLICDTYQGAKKPPACSQDKPKLRSRMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX88</accession>
    <name>A0A8B7ZX88_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110989820</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110163.1">
        <property type="nucleotide sequence ID" value="XM_022254471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX88"/>
    <dbReference type="GeneID" id="110989820"/>
    <dbReference type="KEGG" id="aplc:110989820"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110163.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37656" checksum="4080C1AF24813FD1" modified="2022-01-19" version="1">MRHQKSWTDVVAWMGKLFPDYPSSKCRHLVETTVNRVLRHESASRQDFYKEPVDLNFIGPMCAAADITRKTFNQPPVLRSSPLTRGILLELGSCYGGDCFSAICHIYGGKYNRRTVSTELKRTKTVYTKLNKSKSRSNSAHTFLSEAVSPDIDEQAGTSRSSSGTKSSSNSSVHVSSTENVVKESVKPTATTCKLEKLTRKTDSKLKDQSAEIKTLQEKEAVLTDLCREKSEHIRHLENLQGALKKTVDHKSAKVAKLENQMEVLKTQLHEKSEMITRLKSTTLYQKLRRRNHYISQKEKRIKLEAKKEEDMRKKVKRLQQKCRVQKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXM2</accession>
    <name>A0A8B7ZXM2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110989902</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110989902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110293.1">
        <property type="nucleotide sequence ID" value="XM_022254601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXM2"/>
    <dbReference type="GeneID" id="110989902"/>
    <dbReference type="KEGG" id="aplc:110989902"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022110293.1"/>
        </source>
    </evidence>
    <sequence length="114" mass="13172" checksum="FB3B032B12186193" modified="2022-01-19" version="1">MEAKVQGRKEEKTQVRKGCVEKNDECLLLGWMEDKVQGRKEEVTQVRKGCVEKNDECLLPGWMEDKVQGRKEEVTQVRKGCVEKNDECLLLGWMEDKVQGSEVQDEGNVRWVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZB9</accession>
    <name>A0A8B7ZZB9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospholipid-metabolizing enzyme A-C1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110989105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108931.1">
        <property type="nucleotide sequence ID" value="XM_022253239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZB9"/>
    <dbReference type="GeneID" id="110989105"/>
    <dbReference type="KEGG" id="aplc:110989105"/>
    <dbReference type="OMA" id="KHDNKYK"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="6">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022108931.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21263" checksum="6C48BDDC963698C3" modified="2022-01-19" version="1">MASNNHFGMVGRWYEPNSQDLNALEKTVLQGDRLEFSRDDLYSHWGIYVGRYRGIEHAVIHFGMFEGGAAFSKKKTSGSAVSARTKPKVRADSIREVLGTSGKVRINNSKDKEKDPLSVAVIVDSATEMHREQVEIDYDLFESNCEHFVNFCRYDHAVSDQADAAKDVVAIGVAGLAVGAIAGVAVALTKALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZW0</accession>
    <name>A0A8B7ZZW0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Dihydroxyacetone phosphate acyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110990116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110647.1">
        <property type="nucleotide sequence ID" value="XM_022254955.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110648.1">
        <property type="nucleotide sequence ID" value="XM_022254956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZW0"/>
    <dbReference type="GeneID" id="110990116"/>
    <dbReference type="KEGG" id="aplc:110990116"/>
    <dbReference type="CTD" id="8443"/>
    <dbReference type="OMA" id="RFNLEWY"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000437">
        <property type="entry name" value="GPAT_DHAPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="131"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022110647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110648.1"/>
        </source>
    </evidence>
    <sequence length="665" mass="75062" checksum="84026442BD13C670" modified="2022-01-19" version="1">MAHPSDEYLDLLEPRRRQYDISFALKHTASLLPEYQYVTHMSKAEIRTMVLKSRRLKHTVEELVASQNCEEKEVFAEAETILDEMAHNFTLNNIRFLAYLFSKAFKRLYGHIYVNKSGLEKLRKSYRDSPVVLLPTHRSYVDFLLISYMMFEYNLPLPYIAAGADFNNMKFVNTILRFAGAFYIRRSFGSDKLYWAIFTEYVQILVINGEAPLEFFIEGTRSRTGKFLPPKRGLLQVVVEPFMKGRVPDISLIPISISYDRILEETLHSREMLGIPKPKESTSGLFKASSIFQENFGNIMVHLGDPVSLKQMSLISGVDRSVHSLAPRFIFSMNAQEQQFVQELCLSVQLMQQRHMAVSPWVLSATLLAMSPGYQTSLHNMYRDMEWLKGAAVGLGTKLNWPVGKMVQSVFEEQLAVHRAMVVVDGDNIRLNAPRKVATAEEVMTAATVYIMLGAYRNHLLPSLAQPALVSLAFCGLSAATKDELLAQYQFLVTLFNRELTFHPKTTIDDFQSTVRRLQSSSVISVTGLQYSITSSGERLISFLCSLLHPFLLGYWVVCRYLLSCPCSLDSVTEQSLAKTIQKEIASLIAAGDLKIYDILSLNLLCNAILSLVQLGGIKRSKSGWMLIEVEISKTADKISEYIELPASLLTKLFAKKLAGPAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A020</accession>
    <name>A0A8B8A020_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small integral membrane protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110990417</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111107.1">
        <property type="nucleotide sequence ID" value="XM_022255415.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111108.1">
        <property type="nucleotide sequence ID" value="XM_022255416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A020"/>
    <dbReference type="GeneID" id="110990417"/>
    <dbReference type="KEGG" id="aplc:110990417"/>
    <dbReference type="OMA" id="ACTDTEC"/>
    <dbReference type="OrthoDB" id="10054061at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020309">
        <property type="entry name" value="Smim-14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31019:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11027">
        <property type="entry name" value="DUF2615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022111108.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="15906" checksum="3B62328C5D21275D" modified="2022-01-19" version="1">MAEGGYDPCECVCSHEGAMRRLISMLRDSQQSCSDSQCDLELPHPTSDNDGYITFSLLMITVGWIVLAIILYLTRPSMMQGREDKKQRPSNQPALGWADTAEGPWTLECRGSMWKLNLGDRHWNWAVLARSAEVLGPTTALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2A5</accession>
    <name>A0A8B8A2A5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate sulfotransferase</fullName>
            <ecNumber evidence="9">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110990714</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Golgi apparatus membrane</location>
            <topology evidence="1 9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sulfotransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022111497.1">
        <property type="nucleotide sequence ID" value="XM_022255805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2A5"/>
    <dbReference type="GeneID" id="110990714"/>
    <dbReference type="KEGG" id="aplc:110990714"/>
    <dbReference type="OMA" id="KFIICRV"/>
    <dbReference type="OrthoDB" id="2019940at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018011">
        <property type="entry name" value="Carb_sulfotrans_8-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005331">
        <property type="entry name" value="Sulfotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12137:SF54">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03567">
        <property type="entry name" value="Sulfotransfer_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022111497.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="46507" checksum="66C8B6B3AC020C92" modified="2022-01-19" version="1">MSARRIVRATKKRIILAFLILIAVLYTGFVVFGQGFVVSKTDTLLKKVFSKDAVSSGHEVVGPLDTRQPVLGSNTSSDNNASQSFNATLSDDRATIQGMPEMKQEDEAEFLQRMANVQNVRHDLIRRRCADTYNITEQVDFRRDREKILSWKKFYEHAYANDDFKFIICRVLKVGSFSWRKVIRSLYDKGSPAFKKKQKMGDYPIREYDNETFLVELENYTKILFVREPFARLLSAYRDKYVELRHFPYYKPIGSKIIQAFRQGATRRQINSGKPTFEEFVKWLVRDPDNREGDYHWRPLFDWYHPCEMHYDYIGKLETATEDARYIFKMLGIDKLETYPSTETHHKFSSTKDVLKQYYSQISPELVPKIVYRYREEFVLFNYSVPQTLSDIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2B8</accession>
    <name>A0A8B8A2B8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110991065</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110991065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111868.1">
        <property type="nucleotide sequence ID" value="XM_022256176.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111869.1">
        <property type="nucleotide sequence ID" value="XM_022256177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2B8"/>
    <dbReference type="GeneID" id="110991065"/>
    <dbReference type="KEGG" id="aplc:110991065"/>
    <dbReference type="OMA" id="DWSAHSQ"/>
    <dbReference type="OrthoDB" id="10021476at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039142">
        <property type="entry name" value="NRF1/Ewg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20338">
        <property type="entry name" value="NUCLEAR RESPIRATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111869.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="27502" checksum="6869B71F192B980F" modified="2022-01-19" version="1">MNVVGVANPAAMAATTGTCTDQDIRQIERFFTSLKSRVYVCPALANLYFTTLQEMANLGGWELATTGFPTLIFENRQNERRLVLCIAEKGTGFVQWKDGLNQDSKYRSPERNFHTLCVSGDAQKLAGLSFDNDLAAAELLDTVHAWLEELASEEGSQNAKKKKRKHREPKVTLPKKETISQPCMFEHVTNLDHEKFVQRMMGTVPTIVAPTPQQYGGGSPPENGDTSKMLAYAESTSTEDSGLDELHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3G0</accession>
    <name>A0A8B8A3G0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: uncharacterized protein LOC110989987</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110421.1">
        <property type="nucleotide sequence ID" value="XM_022254729.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989987"/>
    <dbReference type="KEGG" id="aplc:110989987"/>
    <dbReference type="OrthoDB" id="10062821at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034680596" evidence="1">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="117"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110421.1"/>
        </source>
    </evidence>
    <sequence length="402" mass="46001" checksum="F4D7ABAE11ABCF7C" modified="2022-01-19" version="1">MQRLTCLFLVTALKAALPDPAIRQGTFPVGRKKNRRVSKADATVQRSQRLGIMLAMIMYSHRPLVFNFIRGCLSIQLWKHGCSQKLLSYLQNLGLTKGPKGTIGTIDRVRKGFKEKLHTWEKTKTCITQMLASTWSKLRERMTLVVQVILKSASWRTCINLCQCRKESFDDDDHDKDGVLEYSXSLLYQGLYHRALRQAIREGDARVIMDHWRLDIPASWNKKHHKYFILAHKTLVGMSGFYLWRDGNIGIDLVNEFFNKDYKQMLARSRGVCTKEQVQRCSEISGAFGRDLDDIFMSAITGRTGKSSKGQPAEFQADVKQFGAEYKDDDLFEFEPGRRHSAFLKYCHSLHFKDPAKLGVDNVVGERLWGGDEQLTAVGYVMAVARMFMALITKARSRKICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A5P0</accession>
    <name>A0A8B8A5P0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110991241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110991241</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022112230.1">
        <property type="nucleotide sequence ID" value="XM_022256538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A5P0"/>
    <dbReference type="GeneID" id="110991241"/>
    <dbReference type="KEGG" id="aplc:110991241"/>
    <dbReference type="OrthoDB" id="6330326at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034128469" evidence="2">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="3">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022112230.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="13691" checksum="EACFCC891A8CC497" modified="2022-01-19" version="1">MATRTQMLNMEGIFQQFARATIIMNRFIVLLLLCAIAVQQINGHPDADAKHGGNLAYRANYCGATLYEKVRETCHAVRGVSNQEFLDSKDASTFLFGRGIGKRGLHHECCTEGCSIEEIYESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XEF3</accession>
    <name>A0A8B7XEF3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tubulin polyglutamylase complex subunit 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079129.1">
        <property type="nucleotide sequence ID" value="XM_022223437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XEF3"/>
    <dbReference type="GeneID" id="110973032"/>
    <dbReference type="KEGG" id="aplc:110973032"/>
    <dbReference type="CTD" id="91978"/>
    <dbReference type="OMA" id="HFQMECE"/>
    <dbReference type="OrthoDB" id="64214at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22960">
        <property type="entry name" value="DD_TPGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047502">
        <property type="entry name" value="DD_TPGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039235">
        <property type="entry name" value="TPGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057632">
        <property type="entry name" value="TPGS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31932">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31932:SF2">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24480">
        <property type="entry name" value="TPGS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47391">
        <property type="entry name" value="Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin polyglutamylase complex subunit 1-like C-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022079129.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28632" checksum="08ED1FB466789979" modified="2022-01-19" version="1">MSDKRADDKIDSGNNESKREFLERSGVGSWIRDALSKVLSNRPEDAVAFLAQYFSSIGEKSNRLNRAYQYLTLTDHYQPSFANNVATAYEILCSSSGSRTLAGLTGSTYREVLSLICSTIPAPFCEQLLKKIGPRDEEVIYPSVFHSGVMAAFVMIEYLKQTEELFQLLTTHQGRGLVDHELATAMLQELQDALAVRSTDPVSILTAGSKLTNEVITDSLLELLFASQSEHRQMMTREEFVVTAFNIYLKEVKPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGI7</accession>
    <name>A0A8B7XGI7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Receptor-type tyrosine-protein phosphatase N2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110973394</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022079899.1">
        <property type="nucleotide sequence ID" value="XM_022224207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGI7"/>
    <dbReference type="GeneID" id="110973394"/>
    <dbReference type="KEGG" id="aplc:110973394"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000017">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase-like N isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2470">
        <property type="entry name" value="Protein-tyrosine phosphatase receptor IA-2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033522">
        <property type="entry name" value="IA-2/IA-2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021613">
        <property type="entry name" value="Receptor_IA-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038112">
        <property type="entry name" value="Receptor_IA-2_ectodomain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46106:SF4">
        <property type="entry name" value="IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11548">
        <property type="entry name" value="Receptor_IA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034129400" evidence="15">
        <location>
            <begin position="21"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="701"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="879"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="361"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="634"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="138"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022079899.1"/>
        </source>
    </evidence>
    <sequence length="970" mass="108409" checksum="128A2C7198C15215" modified="2022-01-19" version="1">MDMSLFLLAILLASPFPSLTQPSGKLGCRFSPICREDEVCAEDKLFGTCVQRLTSYLPRYELDPPGLKRLKDVVQYLLDEGFAWEDQYAQDSLQEVLQPFKQSIISIIPDLGPPGYQQNPPVPDDNEAEAWANVDHLAKAYQAVLDEYQDRYRAYEELVQKYGFGDDAELNAYAAQMQQKYKSIIRRLQAEERENLRKLYNLYYQKYLSLLEAETGGSQGQTDSQDEWVGNGGYGNNEDWKGLYKLRLLKEYLQLLYNENRDRWVTSSEASEDSYVSSSDETYPLETFLEEWNGDFDNELPIEDAVAVETGVAEPPYQTQEGEGNPYDVFDNLDGGYWKTLTAEEKNEFINEILQLEGDDVGVTKETVDGDREDGGDKEDEKDEGAETAVEGTGEDKTEAPLSKGQGVGEPGKEYVEPLKQPKDSGNNLDANLAKKDEDAFSVVTPEPAKKGPTVPPTKPTTSQQTTFAPSGYVFIALQSGISLEEAQMLVEELRITLDAPKGSFSEIETDERQVTFKVHPDVIHMTPAEVAGAAADHQRNLEDMMGVTITETGVGKQTDITVLDYPRDDNSTLIVVTVVLVACIVGILIAVVTVYCYRQKARVRAKLKGLASNGAAVEGEATADYQDLCRQRMASKSSEKPEPLSRISSVAMSEGANPSPSSRSSTSSWSEEPVQSNMDISTGHIVLSYMEDHLRNKDRITKEWEALCRYEPDISSTEVGALAINVPKNRYQDVLPYDHTRVLLNDSTNAQSSDYINASTIADADPRNPAYIATQAPLTSTIADFWQMVWEQGVVVIVNLTPMTDADTVRTLYWPSEGGTRYHFYEVHLVSEHVWCDDYLVRSFYLKNTETQETRTVTQFHFLTWPENGIPPSPKALLEFRRKVNKSYRGKACPIVVHCSDGVGRTGTYCLVDMVLTRMTKGAKEIDIAATLEHIRDQRPGAVKLKEQFEFALTALAEEVNAILKALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XH35</accession>
    <name>A0A8B7XH35_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973080 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079250.1">
        <property type="nucleotide sequence ID" value="XM_022223558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XH35"/>
    <dbReference type="GeneID" id="110973080"/>
    <dbReference type="KEGG" id="aplc:110973080"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000025">
        <property type="entry name" value="Lysine-specific demethylase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF37">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="149"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022079250.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="61402" checksum="98263098860E0A82" modified="2022-01-19" version="1">MCASLSKLDSPTMWGPATSHVLLITLAVLCERTGQHSSLDASNLDIFYDPAAKAPLGSHREPTDFLDELYEVPGPEEFNRRYVSQYRPVVFRQAARQSKAYHLWTEEYLTQKYGNLTVRLEARHEENSRIPAGVGGLGRDTIAHFLQHYQSLDGYIISTVPSPMEPDIAIPPCLTCGSFSRSIQEVHLFLSSKGGKTLLHRDPYSSVHCVFNGTKQWLVIDPKQKASLYISEESTYEFGGYSTIDVDNADLTRYPKLRNVEYARVILNKGDCIYMPSGYMHQVRSNGYLNAAVSIWFSHYYEFDNKGCLDNHGPADFRPMNEVDVLWRYSGHGNLSQGMMDIHVLRTVLQTVADKDGKIWIDSFVTNFIYGEKNDPGYYKMRQDSFRSAIDPSNRGYITVEELNSFSISQLKDLVLSLKVLDPSDTDRFEYAHIQAYDVRILYEDLLSESPDETFKRSEFVEAYVEDLGGTSVVANEILDHFGKDADTITAEMVDKMADASLSQFQEVPEFDPFLEHLWYKHLVKEGIIQKFKVVHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHQ3</accession>
    <name>A0A8B7XHQ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Thyrotropin-releasing hormone receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110973257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079642.1">
        <property type="nucleotide sequence ID" value="XM_022223950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHQ3"/>
    <dbReference type="GeneID" id="110973257"/>
    <dbReference type="KEGG" id="aplc:110973257"/>
    <dbReference type="OMA" id="ESFALCH"/>
    <dbReference type="OrthoDB" id="10011262at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="83"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022079642.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="46649" checksum="D1911B415F80D291" modified="2022-01-19" version="1">MILLPLDIPDSTMGTLVWEDNSNVTFHDTAAPAGSLEETDGNVCQFFENYTSEEELERNTYSQGQVLFVSVCLPLIMALGVINNFAFIYVVIRVPRMRTVTNCYLVGLAVSDVLFLVFAIGSKIVCYVSSPIYGDDTPLGLSGCLLTQFIINTSYFATLCFITLVSWERYNGVCRPHRKRDTKLRIFKLLAASCLASSLMSATLSLSLAVEIVECITWPDGPPYDTWPTQRYLYYPVFDWVDKYSYGAQTIPFFISLTINVFFYQRIIKGLDKSMNRRHLHSNHRCSGGDSSTRNQIARMLVVNGITLFALLAPFEIMSLFQLIGMLRDHNFILTVEVRGPLVAVARVLSYINAVVNPVIYTALSSRYRESFKITFMPTQCRPRQRQRIENSVHGSTVTVQCGVTSKIHESRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIM6</accession>
    <name>A0A8B7XIM6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type E3 ubiquitin transferase BRCA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110973502</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080061.1">
        <property type="nucleotide sequence ID" value="XM_022224369.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973502"/>
    <dbReference type="KEGG" id="aplc:110973502"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031436">
        <property type="term" value="C:BRCA1-BARD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17721">
        <property type="entry name" value="BRCT_BRCA1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16498">
        <property type="entry name" value="RING-HC_BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000006">
        <property type="entry name" value="Breast cancer type 1 susceptibility protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031099">
        <property type="entry name" value="BRCA1-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13763">
        <property type="entry name" value="BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
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    </evidence>
    <sequence length="3410" mass="373049" checksum="6163764912BC4EDA" modified="2022-01-19" version="1">MSMNTAVRKVNHTLGEIQKNLECSICLDLLKDPVSTKCDHQFCSFCILALLDNSRRSSASCPLCKEPVTKRSLTSNERLNEIVRAVRSVVEAVEEDTGLRCTPPRGPRVLSQQSKPSPQAAKKSRQNKPVRRPTASSSNKTSRSSKRGNLRQAKPRSTGSFAVYIDSDDTDSSEGSTQEVLITDFDSTVVGKNAIQKSHKKPVTRTPLQPTNQDSTCTMKGTGSHRGSSSNASVLPSSKHSSENGQIEDGRNLLEVLDEGSQGILGNGTPQEERQTGKAKDKFPGETSHELDGRLVRAFDRESLRMRVDRAGEGTSQEKSRNGKASKKEVLKVNNSETSGSCVISDADTTCPENVSKSPTSKGSLSSSADDDLEDDPYEFIASQRTPRKLKLKRSRRQKNPSGNAAKGFDYMKWKRSGSAERKHPKGSQVVVSQPEPQNEVCNITNESLQVFKDHGFIKPCDAARITDVDLPISGKQQAAVAEHVKPASCDSIPNGCERTAAFRRRTWSGEQKQNSSGKMVHHSGEAVPNEANTPHPTDKELHMSKVCQDEATKVEMRKKPTSRGRQRKNKNVKQPQDDFHEDQGRLPQQTSTRRLRSKTKVQEDGKENGEAHTCDSKKVLKVQSKQGGASQRGRQTDEPNEINQSGAEESHVPGKDTKAREALEESHIAGMSSDEDGDYRFEEASCHGDNDGESTQVSLTDPSYEPSTVAAEPSTSVIIHDATPQKRLSRRKESSELINAPHYLSALEGASFEDREEASEVMGCSQPVVKKHSPLATSGAFGQVYKRGSLQIKQSPKGGNLTEIEESKKHLDDKVQMMFPCDEDSLGEESETATESDKDGITEKSKTEHHTKSEGIPHGSTPETLVSQPNLFDKDNQPKDDKVVDLTEESDVEDPNEDQIYSHPDEVKQSISNAGLEKEIIQKDGTTLQLKLSDAAAIKSDWELALELAREFDTEPRHFRLRSSRRGKTETELKEEPVQAGRAKPELDVFVHRVRGHVKSRLAQEAGSKICQSQTGANADETGKKESRSQPNKTPEAELNEDHIIIAGKKTLRQPQRSGRTDVGKNKLPTTRSKGKRRSRHSSGLPPAHLEGLDGEDGGKIESYDSNHEQVQLRSKRKKPTAEQVATPEVQKPMKQDFFPSTSKKEANEAVIHVPQDVALTSDKNWDEISVQNVPGNFSSRMELLMSPLPSSPVASNNGTGGTSFPERRTRQNSGNCHKVSSESPEKMANEVANSKGRNSRLRKTRSSCNKVTRASPTQVTMSCEGHDGIPPASFVSPNKVPDETSQLTSAESNSSVNKKPDLTPEVTQQHSAGSASLFTEDLGGEQAEAQKQKQTPEHTESKTAVCTQGTVVDTEDDGCREVESDGDTTESIDLGSGEDDQDEVKYDQDNIELAHSPFAAAAHLSGSDTDSIELDQDSDNVIFISGPKKSQTAKASINRKTHQSPEEGPEEGKVRSAVIHSPGSPSQEMVSFKKTPAGKASKKTKKMDIPVPAETSPISRKFIKCGEPTSSKRRGGLESSRSQRNTVPETIPSQPSEDFTLRARLPDSNPKCETAVMSGNVQLCKNTQSPQTSLKQRSKASPEPSSLNTLRASSSNQESERMLISPPAHYQETFMATSSNAKSSISQDQSQEKHLSSTRSKLSLKRKSCPEEVSSPGTRLANKRHRSAGATVTEIKHWDMGSRRRSERLSRSATILHENSSSCEMTKDSEDIPTSLKKAEHVSEGCITMKTNNDVTADVRRRRTSASLSRPESQPRSQKSSSGGKASVLVEACSQKQQAVSTASPQLKLSQAVHQEDVNIELSGHQAKDSPQTISGSCPLFEEDCCSLCSSQKLTGSQDASLPDISLFSSEGSASSSLSHSRSSPSSSGKSSNTHRNQKSILKQEKAESGGKKESHNSDTDPLQKNLIDSTKSLFTENSSVHSKKHSALSGKLSSSLKSSDTSRASLSIPFQGKPDNGRPKRGSGSHGRKSQVNTSKPPSEEFVAASEGASVSSECLSDPIILSRRHRYGPADVSTNVQDTPESAKDKASSQHHSAVRGTELVPGSRSRKGFSFRMKSSRNQETDVSSSSQSQSNTGVSKDKSQEVRLVDFSSSNRSVKQQSSNNQQKQQMHKNGDSLCPENAVNTEPPSSLSPKSKTRARKSSTLTVGRVKQARQGEIYLDKTESQTSRNIRKSSQVYEGLLQRESYVDCSDLNEVNLQKDRIREPSRSHETFPDDRVRGDTSGLNIQANLSDRQHGQAGGRLDSSGDVEMVSAEDDEPHCVEGEGIEGADDDTDVKEHDVGEDEIDESEEDSDDENDNSDQDEDIIIPPTPPGQSTANFHTRKRPAYLVHSISLSSNTSRLSTRSTASSRFKAHHAGTSSNKKDPSRLSQNSGSGKKDPSRLSQNSGSGKKARPNLTKNGFSGESNFSSRRANSKSAAQDSGSKGGSHAEDKDMADNSFQKRIFPLSYSPMEDDASEDVAENTPSLSIFQECVKDESPKDKLKKSPKSKSSSRSKKSLPMDQAQVQDKPRDARAQGHEDQRDSFLESPCERSSAGRITRKQQSEQLPDIHQEARCVQGLAREKEVSRCETPEVVILEKLTDEAAVIKDKGKVGAGICQEEERGQEEEVMLIGADQHYDTEGSTCSESSGSHHLNLTSASSVLSSQSELMSTQQRLKAKESLKKMALEIAQMEAALAEAEFAEHLDKHSDTTPVEHPDEIVERIQPSAYHQNRDKIELSKKSQDEMNSQSDGDDFDLHDDPVSEADPVSEADPCQTSDDPCTPGDLFNPEAPSLYNAQDDMTKDARSMKPISHSRRAAPENNCPSQSLSNNRKSSHSTSKRSRSVISDEELESEEDACDGFSDATMPGQNIRRHGTSIAFDREVACVSDSENTKQTKLLTPGGNPSIPSPLSLPHSTSKRMSPHAVLPQEDASVIGAFPKSQLEIPGVTTYGSDSDLSEQEDPHISSESPRSPSPPRSPSPPPELSQRTVRRASLVNLPESVRAVSLLVEKIKSRQGSDEGSSVKEARRSGKRRTADESSDHPGMRIISNSDSDDEEYGALSPKSRSRFGKRLVPRQATTPGQSTSGWKSKVLEMLSDSRAKSKTRNAPKTSGGKKHTTPARKSRQHTQAEPESEKWSHHSRGLAKKNNPGEVRKDKKDGPSGSNHLTRRDNQHQDEIPEDGPPSPVIGRSLLTTPAAKKKAKPMSFVTTGLNRTDMRDVEQLTKRFGCRFASTFNACTTHVIVNTDDDFVCERTLKYFQGIAARVWVVSFKWVTACLKTEQLLLEEPFEVQGDVVNGPSHNGPRRARLCRGPYPLCKHDVCCVGPFTGLTKEQLVSLLELMGASTVQHPSLFPYKAGRKVVIIAQAEATDSEHDYDALYKKYRVPVVSREWVLDTIATYKIQPMTDYLLSESGSSQPVIDLDSDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJJ7</accession>
    <name>A0A8B7XJJ7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tetraspan membrane protein of hair cell stereocilia homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110973996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080968.1">
        <property type="nucleotide sequence ID" value="XM_022225276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJJ7"/>
    <dbReference type="GeneID" id="110973996"/>
    <dbReference type="KEGG" id="aplc:110973996"/>
    <dbReference type="OMA" id="LIYPASW"/>
    <dbReference type="OrthoDB" id="5873721at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019372">
        <property type="entry name" value="LHFPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489">
        <property type="entry name" value="LIPOMA HMGIC FUSION PARTNER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12489:SF1">
        <property type="entry name" value="LP10272P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10242">
        <property type="entry name" value="L_HMGIC_fpl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022080968.1"/>
        </source>
    </evidence>
    <sequence length="355" mass="37914" checksum="C9C90D8E889BBC09" modified="2022-01-19" version="1">MGNSSKEDTYAYYYHTNYIRNARAIAIAWALFTFCFAIIMCVVLVQPYWLGDGPDATGIGYFGLYRYCVSFNLAGQLVCQNALLDVSQATQVIPVTMFVATIFVAVAVAFLLLSILCMLLFLCKKPSTATVFKICGALQLATGLFLLIGILIYPASWSQLAAFVTICGPDVSYGNAGKCQLRWVFYLAIVAIFDAIVLGVLAFILASKQEKLATDMQFSDYYPASKGNFSNGKKKSSVSGYPTASGETGYPSTNRQNGTAGSLDRRSNHSGTTASDRDASRSNGGSSVNRRGTDGSDPLYSSVVPRRERSRASSSATGGAEGDDEAGSTRSGISSKSGKSSKSSKSGKHVHDVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMV3</accession>
    <name>A0A8B7XMV3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Frizzled-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110974656</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082154.1">
        <property type="nucleotide sequence ID" value="XM_022226462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMV3"/>
    <dbReference type="GeneID" id="110974656"/>
    <dbReference type="KEGG" id="aplc:110974656"/>
    <dbReference type="CTD" id="8322"/>
    <dbReference type="OMA" id="HWGEFRA"/>
    <dbReference type="OrthoDB" id="5959102at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15038">
        <property type="entry name" value="7tmF_FZD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07448">
        <property type="entry name" value="CRD_FZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000020">
        <property type="entry name" value="Frizzled class receptor 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000008">
        <property type="entry name" value="Frizzled receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000539">
        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041765">
        <property type="entry name" value="FZ4_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026551">
        <property type="entry name" value="FZD4_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF23">
        <property type="entry name" value="FRIZZLED-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01534">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00489">
        <property type="entry name" value="FRIZZLED"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0807">Transducer</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="19">
        <location>
            <begin position="75"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="20">
        <location>
            <begin position="268"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022082154.1"/>
        </source>
    </evidence>
    <sequence length="582" mass="64920" checksum="7D658ECA8AE576FB" modified="2022-01-19" version="1">MACQREEGRHRGGRVDSGRGDPGAEGRLTGGRGGAIPARLPLPWTVFTLLAVLVVLLATGPPCARGQDHFDEFNPKPQQCIPITIKLCKDVGYNVTRMPNLVGHELQQDAELQLQTFTPLIQYGCSANLRFFLCSVYVPLCTEKVDIPIGACRGMCERVKNKCEPVLKEFGFMWPASLNCSKFPPQNDARTMCMEAPEPDSDPGDRPDRGHGGGGMRPIPTLPTPGPSERDCQHKRSPYKWHYVKRNEECALRCDQNLLFNSNEKHFAQIWMAIWASMCFLSTTLTVLTFAIDPSRFRYPERPIIFLAICYSVYSIAYVVRLVAGYAKIACDEDGETSFLISEGLENTGCAVTFLLLYFFGMASSIWWVFLTFTWFLAAGLKWGHEAIQMHSTYFHLAAWGIPFVKTVIVLIMRVVDADELTGMCYVGNQNLDALTGFVLAPLFTYLVLGTLFLLAGFVSLFKIRSVMKNDGTKTDKLERLMVKIGLFSVLYTVPATIVVACHFYERSNRTVWILLGLTPNVEVYMLKIFMSLVVGVTSGMWIWSAKTLLSWRRFTNSLFPTICGGKAGNVYVGPGGNETAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN43</accession>
    <name>A0A8B7XN43_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ras-responsive element-binding protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974734</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082244.1">
        <property type="nucleotide sequence ID" value="XM_022226552.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974734"/>
    <dbReference type="KEGG" id="aplc:110974734"/>
    <dbReference type="CTD" id="6239"/>
    <dbReference type="OrthoDB" id="3069995at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001788">
        <property type="entry name" value="ras-responsive element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000682">
        <property type="entry name" value="ras-responsive element-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000448">
        <property type="entry name" value="RE1-silencing transcription factor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052795">
        <property type="entry name" value="RREB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46451:SF1">
        <property type="entry name" value="RAS-RESPONSIVE ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13909">
        <property type="entry name" value="zf-H2C2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="448"/>
            <end position="475"/>
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    <feature type="domain" description="C2H2-type" evidence="7">
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            <begin position="476"/>
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    <feature type="domain" description="C2H2-type" evidence="7">
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    <feature type="domain" description="C2H2-type" evidence="7">
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            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
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            <dbReference type="RefSeq" id="XP_022082244.1"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN74</accession>
    <name>A0A8B7XN74_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ficolin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110974243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081435.1">
        <property type="nucleotide sequence ID" value="XM_022225743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN74"/>
    <dbReference type="GeneID" id="110974243"/>
    <dbReference type="KEGG" id="aplc:110974243"/>
    <dbReference type="OMA" id="NECYTAN"/>
    <dbReference type="OrthoDB" id="9945370at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022081435.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="22044" checksum="E34BDBE030647D53" modified="2022-01-19" version="1">MYTCTCVSSQSKVFQFRHDGNDSFLRDWDDYRLGFTSPHGSILWLGNENLHRLTSSGSWVLGVLLVDWADEARSSFYWNFRVSDESQGYRLNIDSYLSIDGDAGDSLSMHNGAKFSTWDKDNDVSDVNCASLYSGGWWFTDCLDSNLNGEYFGTGNHTSALTNQGIIWSSWKGRHYSVRQTMMFLINNGSEVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPW3</accession>
    <name>A0A8B7XPW3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Lebercilin-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110974592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCA5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082035.1">
        <property type="nucleotide sequence ID" value="XM_022226343.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082036.1">
        <property type="nucleotide sequence ID" value="XM_022226344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XPW3"/>
    <dbReference type="GeneID" id="110974592"/>
    <dbReference type="KEGG" id="aplc:110974592"/>
    <dbReference type="CTD" id="167691"/>
    <dbReference type="OrthoDB" id="2123794at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026188">
        <property type="entry name" value="Lebercilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028933">
        <property type="entry name" value="Lebercilin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16650">
        <property type="entry name" value="C21ORF13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16650:SF6">
        <property type="entry name" value="GH21622P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15619">
        <property type="entry name" value="Lebercilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lebercilin" evidence="5">
        <location>
            <begin position="211"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="977"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="223"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="606"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="638"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="726"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="807"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="863"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="940"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022082035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022082036.1"/>
        </source>
    </evidence>
    <sequence length="1020" mass="116180" checksum="1A951586127D4392" modified="2022-01-19" version="1">MTAVYDNDSFFDSDGEHDSRKADSPYLKGAYDRGSSPPTEVGTQRGAKNKSLTPSTSGNFSAKSSDSIMSEKSGAKSHRYGHSPSPPRSPSPYRSPYTQSPAYSDSFNSEDSEQDSRNASPERARQVSSKKPQHTGRARGGYSSTSSNRFNSGTSQDSRATYKSSNYGKTINRTKKAFQKTPLKKSVAAANTKRSNSIASSQASPRNTNEVTRRMLSAKGHTISRLRNEFNQLQKEHDETVRENKLLKELQRRQERALAKFDSEESELPQLLKKHSAELDSMRRRIRKYQERDRDRERRLKDKDEQYLRAEDELKHIRALAEDKGLLERHELQRKLDRLRGKLEARDKKLGEMERYVEHLKKNQRHELHERQGREEELKGQVASLEMENERLQNQLREKEKELEVRNIYSNRLIKPPGKLRHNLSPTGLKPVMLSKATSTDDQSKHPRPPPTERQQREWSAEEVRRREELTTRVKSPKDATPKTEHKVEPEKPKQKEPKSEEPSEEPNKELSEHEKILRDLDMGWGRRDGGEERQRQEEGRRRQLEEEERRKKEEVRQKELEERLRREEDERRRRRAEEEAAARKKLEEEEKPSVYKRPSFFGSKQDASSSQYKPSFLDSSPSTNSKLSFKRDDDSSSYKPSFFNTLTKPEHPQSNQNVTSATQNPQEMTPSSVSANPKAKSHILDDDDDFFETQPPSTNLPAWLRDSSNTTEVEREKKKKEVLEEASYSPDFDNSPNDNDSEENIPFFGSKPTGVQKPPVAKTPPYAVNSVRDLHRYSRGDNNSNIPKQGIDEGGQIDLNQANTADQEKEAERVAEERRKKDLLLAKMREIDDGRKPDSGRSHKSYNFTKPVENLHNGVPSHPEETGPAKGKKDDALLFGSYAPTFTSGKVAQKPKKKSFFDDDDDSDSDLFSKRKPATSPQGDKKSNLMADLFGNSASEEKVTKSSFGEDKNVFTSSTKAKPLSYPWEKKVDVVGGTNAASPGAANSSKDKGPSASKAVMNMSHDSLDDIDDIEEVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPY7</accession>
    <name>A0A8B7XPY7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110974622 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110974622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082106.1">
        <property type="nucleotide sequence ID" value="XM_022226414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XPY7"/>
    <dbReference type="GeneID" id="110974622"/>
    <dbReference type="KEGG" id="aplc:110974622"/>
    <dbReference type="OrthoDB" id="438268at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034030393" evidence="2">
        <location>
            <begin position="21"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="35"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="258"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022082106.1"/>
        </source>
    </evidence>
    <sequence length="450" mass="51131" checksum="B5E28EFA057E3DB7" modified="2022-01-19" version="1">MYISLYIIASACWLLMAAQGGNPEPHLKVRLPSSPTKISFLEEPSNVHVDQNGRVRLRCHLSGLQPYHIVTWSKNNQTISKGKQLTGDRFMIDRHRYTIAGGYRRGYYDLRIWDVVRLDTGNYSCSVYQAPTSNSSRSDHGPLLLKSRMSHVTVYYLPPLSYPECPTEMRYREIQVGETVPVCHSQKGFPPINLKLENPLDASRVKVDSTSVSDFIFVTLNITELENGMTYWCKASSKDFPYYQSRCQVGPLNVVYKPRAVIRPLRYAIHKTEDAVFVCEIESSPMSSQVSWNVHPPIESNRIELYDNNRTLQITGIRSDDDGRLLSCTATNSQGNDTAHRVLVVRQPDFIPHLEMTPAAANTSMPAKLDTSIPHCWNFAYRILVPTLIGIIVILILVIVVLLVRSKLWIFSKRLDEHSAQTEIMRPLTDYEIPPAIVPIDNKQLMLNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ13</accession>
    <name>A0A8B7XQ13_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16">Bombesin receptor subtype-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC110974637</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082131.1">
        <property type="nucleotide sequence ID" value="XM_022226439.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082132.1">
        <property type="nucleotide sequence ID" value="XM_022226440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ13"/>
    <dbReference type="GeneID" id="110974637"/>
    <dbReference type="KEGG" id="aplc:110974637"/>
    <dbReference type="OMA" id="HAFTTSH"/>
    <dbReference type="OrthoDB" id="10049706at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008188">
        <property type="term" value="F:neuropeptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001556">
        <property type="entry name" value="Bombsn_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF26">
        <property type="entry name" value="NEUROPEPTIDE CCHAMIDE-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00358">
        <property type="entry name" value="BOMBESINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="45"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022082131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022082132.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="42891" checksum="7E897FAFE212496B" modified="2022-01-19" version="1">MASLTTALPNVTGNYTDDYHSQTVDVYEIVSMVFLISFGMLGVIGNGILVCIVLLNPDMRSVPNILIASLGLGDFFVVITSVPFNLVSYLYNSYPFNSAVCKFSSAVPIVSHGVSVFTLSALSYDRYMAIVRPMQRRQSNAVRRTYAVAISIWVTSILLGIPTTILAKRDLIYPSGVEVAICKTLPVNITEEYGAIPTVTAKVHEAVRCLIMFVIPLAIISMYYILIAKQLAQSSRTIPCENHGDSRQLRARRRLARTVLVLVVIFAICWIPHFMYRLWFNFSFSLEVFSSTGMFILQIVSVLMVYANSCINPIALCFLSKTYRRYFARYLCCQRNRKLSHVRATRMNMYPMSPGTPTSTIYNKRSVDGSLRGSSVETRACTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ27</accession>
    <name>A0A8B7XQ27_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110975093</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082929.1">
        <property type="nucleotide sequence ID" value="XM_022227237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ27"/>
    <dbReference type="GeneID" id="110975093"/>
    <dbReference type="KEGG" id="aplc:110975093"/>
    <dbReference type="OMA" id="RTMHESA"/>
    <dbReference type="OrthoDB" id="4369127at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="33"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022082929.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="62449" checksum="15C723C0CF17CEA0" modified="2022-01-19" version="1">MKRDVEHYCTRVCRCLKDKPPARYNKESLGTITTTAPFEVVSVDFLRLERSKGGFEYILVLIDNFTQFAVAYATRDKSAKTVADKIFNDFIPRFGYPSKIHHDQGGEFENKLFRRLQELAGIRISRTTPYHPEGNGQCERLNRTLLGMLRTLTEEQKSNWKDSLQKVVHAYNCTSNTATGFSPFFLLYGRSPRLPIDIAFGLDRQEGPAAEDHNLFVSRWKTQMKEAYALAARNSAKSSDRNKRYHELKVHSSVLQPGDRVLVRNLRRHPGPGKLRSYWEDEVYVVKRRRGEDSPVYEVMAEQGSTKSRVIHRNLLLPCDSLQQEDAPQQTPQPARTKRARKRPPDPHQRFDDADESSDDEPNLVMVTPTGQLDQADVNQELNPEAAPFVRAPTELDVATPHDPAGLDSATHDAAPDSDHAVPDIQPTTTLQPENPDTTADDATPSTEGLADPEDYTHPEVQERPTRNRHPPRIFEYVQLGIRATHSMHPRVDAVSLIPPQMYPMQAPNPPVPVMSMWVNPYSHQAPPLMPTTWMRNYPYAPPWTIPGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR58</accession>
    <name>A0A8B7XR58_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110974871</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022082476.1">
        <property type="nucleotide sequence ID" value="XM_022226784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XR58"/>
    <dbReference type="GeneID" id="110974871"/>
    <dbReference type="KEGG" id="aplc:110974871"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047170">
        <property type="entry name" value="PTN12/18/22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983:SF2">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45983">
        <property type="entry name" value="TYROSINE PHOSPHATSE N18, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="10">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="318"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="457"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="588"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="680"/>
            <end position="721"/>
        </location>
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    <sequence length="1043" mass="115814" checksum="F1635A65CC9F2DB7" modified="2022-01-19" version="1">MSQREHLEAFLQHEEHLRMLATNGEDGFLKEFMALKQQSMRYKTEKTFSTNEGERDSNIRKNRYKDILPFDYTRIVLPEIEDVEGSDYINANYIMGVNGKNVYVAAQGPLPHTVNDFWRLLWETGVEVVIMACNEYESGKHKCEKYWADENETKQFGNVTVSLITQLRVTPDFMIRTLKASNQEEERVLNQFHYTAWPDHGVPKSVKPIMDMIQLFREYLPSEESVVVMHCSAGCGRTGTMICIDYVRALLKAGKVGADFCLYDIIMEMRKQRPAFVQTRDQYELVHRAVAWLFRKELGLAPNPHDFDHLYENVKLHNEGPRMPPGAGNLSPDIKPTQQLKLSPKQRRQKDKEQDHGHNYVNHVIQGKGSSSDGGSTSAPANMKILKPPSLPTKQQRDTDTSETVYANFQEKTDTEEKLDDACSSPAVTPKHSPLAQERFESGYKSTLAAFKEFEAPPLQVKPQSPKSIEQGKPTPRSKPVLSVSSTKSLDLDLGKPILPAKPPLSDKPAIGEKPVKVLPSTRPNLATKPAFVRKKDTASGGSPHGTSPSSGLKRRPTSEPVPPQDHEKVHHLGAAQFLLAKNVVKATLSNKSEGDDRKEHEVKKGKERRDSQGRPTSAPPKPPTAVTKPMTKTAATKHQPYEAVDIALPLGRDAASSDKEDSAKGFQYEIKPVVTVKLQSHQDKVDTKSPKNLESSLTQMQHRKTIDAARPQQPVPESGSSEYAYAVQPVNVIEKLKDAQSRPQLKTGQGFSYAYARDSVDDGTGTPKESSKSPKILDDYSYASDVIIPVTSVNRESSDGKNTGQSMAYEVIQISRPPSQKTSEEAGTDDIPVFDKGPGEYNEPNFISYRQVSEQSSSGQTRESVLSSTSWASFTDDDYDYNTDEQPPTIPVKTSAAYEYVDGEEVDEAGSGSSAKPKIAQFLANQRDKLATHKDKLTSNTKGFLTKIGDAVTRNAPASTGNRSSPPSTLSSSPQAGIVSDLNEIIKKTLREFEPTYKEEPNMFQGRDISFPKRVPSPKSPPPLPNEWIQSDTQNSTASVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XT45</accession>
    <name>A0A8B7XT45_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Neogenin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110975666</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. DCC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084033.1">
        <property type="nucleotide sequence ID" value="XM_022228341.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975666"/>
    <dbReference type="KEGG" id="aplc:110975666"/>
    <dbReference type="OMA" id="GCASACC"/>
    <dbReference type="OrthoDB" id="114660at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="DCC isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010560">
        <property type="entry name" value="Neogenin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF29">
        <property type="entry name" value="NEOGENIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="6"/>
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    <dbReference type="Pfam" id="PF07679">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06583">
        <property type="entry name" value="Neogenin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034219511" evidence="12">
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            <begin position="41"/>
            <end position="2198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="1129"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
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            <begin position="44"/>
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    </feature>
    <feature type="domain" description="Ig-like" evidence="13">
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            <begin position="344"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="473"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="570"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="666"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="769"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="881"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="14">
        <location>
            <begin position="977"/>
            <end position="1074"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="439"/>
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    </feature>
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            <begin position="1278"/>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_022084033.1"/>
        </source>
    </evidence>
    <sequence length="2198" mass="237708" checksum="46DB52EBDECD5270" modified="2022-01-19" version="1">MAHSRTKLNWKSGYCMGISRVPLFCLVVCVLSLLSPSTLGQDVPDFNPVYFTSEPSNIIAVPGSAVTLNCSVYSLLVPTISWTKDGSAVPADDPTKRVQPSGALRIAPVSLDDEGSYQCSAELEEGDFFASLSSRRGAVTVAKLVLLDGPARTAAFNGDTVYFECNFNSVPAAEISWLKNGQVLDLTEERISARYTLLPSGGLEIREVRSADVGTYLCRGTNQLITTPVQSFGADLTINPGTNPSSQFNFIRTPQDTEAPVGQTIVLEAATNLPAIFTWFKDGSEIIIVGSGTEDHYTLLGQGSLEIRQIGEIDTGLYRVLATSIADGTALPVDHTVKVTALVPLKFNIQPVNTYTNVGSSVTLNCNAYGIPGPTTTWYKEGEELEPGDIYLVSAGSLTIEQVIQEDSGIYQCVADNRLENIQAAAELIVLREGVPIPTRPPTTTVTTLPAPPQPITTKSPPGPADTGPVPTKPLELEATDIQAQSFRLTWREPSQLNGDLQSYRIYVKWNDAQKVEIVRDLSQLAKVISDLIPETTYRVTILAINENGAGASSDILVVETLPHGEYLGPPTSVRARPEEGSCTALLVTWQAPQGDVLNYKVYYADLSAGVSQELELYTEQNFYLITGLKPYTNYGLRVVGYNINGPGTSSENLEASTSQCKPSGIPDNISAEADSTTSITVTWEPPPVNQRNGLVNGYKMKYRTKENGKRTHSLIIDGNERSYTISGLVRNTAYEVRMAAYNNNGTGPYSDWIEITTLDIDKNENRVPPQPLSIRTTTTHNRIDVFWEPPSDDSIMVRGYILGYGASVPDSLLERLPSSETQVSLTNLLPSTLYVLKLRAFNKVGEGPSLYIDVQTKQPTIGPSPTRIIHVTTRTAKPSVPMELKATVTSPNSILLTWRDQDYSPDDKPPDRYYIVQYETSSKVMFENSSDTSIAINNLSPYTKYFFTVVAVSGNRESGVSMQAFNTTFETAPTSPPRSLTIDDVKNSTTTLELRWQLPKTPNGQITGYTIYYSAIDSREDSDWTDVTLDGEEVTTLISGLTSGTIYYFKIQAHTSKGAGPISEVVSHTTPVGRPVEPGPLNPALDLPTIPLLPDRPLIPARLPKPTAEEEPTSPPPLANAEAMGFPWWLWLVIILAILFIIIIAVLLLLCFLCGCCACCADCCPCCAALCEDACGCCAPFCGPLAACIAACCPCCCEDEDDCAKCWLKCCCGAAACVCCGHSYRERRKAKGSANLVGYQSVSQNGKVSGTVPPDLWINHEGVEMKKVDGKKGGIAVNSKAEERERLEQGGGVDQQRDQVQETSFTQSSVQNQQESRMQECMEEQTGSSNRQSQYETPTLISATSHRSSLESDLHVGGTGSGAVHYATVDEMRRKKSSLKETRQEAANWGSIGKANPRPLTPNPEASLFGPQVPPPYQRIGCIKRGQRPNFTEQDANTDTIPLGSSAEDFARQRAPSITISPPQTQTQTLNRSEVQNRAAGGTTPRYATWGAKTIQNDRQQSNVNYNTTNIHVEDVRNNYTANDGFSTLRDGGYQGSMGANGQTYSTLDRQTSYNNAHSGQNQIITFPEQNAGPQPFTITFEETTTSHSVEKSVPLPDGTSFKTSSSHQTFSKSYSTSDAAQDQNLQAMLQGGIENGPLAIEIPSTTNTALPAIAAAPVYRSASFNPIPQDSPSTGTQSSSISNTLGRSPPPPNYNFITSENASAQTQSSGYASGSISANNRGRTSSIGASSVDSMGYRSRGADSYLSTQDQRSNFGTTSPVSIPAASTSPYSSNFQTYESYRSEERDNSYGRSASDLYDGSPEIGVTRPKAGFHTIDRSTGFNADSAYGSPTSFGNGFGSYGGASTLGKQPSGSLSVPSARPGHSYQASAFQNTSESFRSYNSGNVGTRGTSQFSFNNNNASTEELPSRLVEVEHAEVQTPSRFNSKSDLLQSTSSSLGGGFDLSTPTRPLRRSMSVDNEFGLNNDGYWSGSSKTNLLSGYQTQRETKESKEYSLSSGTETQRGRSRHIGDRTYGGISSRSRSLDRFGDREDHHVSPVGGYDYHSSTPRQHQMDRPAYMYPTNTTSSGYHSDTNTTSSHDDGSSTQGSTSRGGNPLTSFSVPGPPPNYQAAKVKIQAPAYSPLKRNQQAGVARVRHQPLPVVTPRAPDVTYRGVGDGTSPGTANRSFSSEDLNTEMLNLEGLMKDLNAITASELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTR6</accession>
    <name>A0A8B7XTR6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">28S ribosomal protein S28, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083400.1">
        <property type="nucleotide sequence ID" value="XM_022227708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTR6"/>
    <dbReference type="GeneID" id="110975318"/>
    <dbReference type="KEGG" id="aplc:110975318"/>
    <dbReference type="OMA" id="VYGKIFH"/>
    <dbReference type="OrthoDB" id="6020229at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019375">
        <property type="entry name" value="Ribosomal_bS1m"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13447">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13447:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10246">
        <property type="entry name" value="MRP-S35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022083400.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21981" checksum="EF8972FF3989EC3D" modified="2022-01-19" version="1">MAAPMRLGVSAIRLARKLSQIRSLRGLNAPRATFCDTSDNRDSSEISRLDQSGESTEWKAEEVQPKLTGFARAFAKHSAVQQTGLPETDASPETPQSFAKLLRHSSHVHIGNAKGQIVIGKIFHVVDDDLYIDFGGKFHCVCKRPEQDAEKFHRGTKVRLRLQDVELTDHFIGAARDLSLLEADADLLGLAKPHTQTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUR6</accession>
    <name>A0A8B7XUR6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aminopeptidase</fullName>
            <ecNumber evidence="17">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110975999</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="17"/>
    <dbReference type="RefSeq" id="XP_022084589.1">
        <property type="nucleotide sequence ID" value="XM_022228897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUR6"/>
    <dbReference type="GeneID" id="110975999"/>
    <dbReference type="KEGG" id="aplc:110975999"/>
    <dbReference type="OMA" id="FSERYYI"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000013">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF301">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 17" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 17" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 15 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="20">
        <location>
            <begin position="121"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="18">
        <location>
            <begin position="355"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="19">
        <location>
            <begin position="645"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022084589.1"/>
        </source>
    </evidence>
    <sequence length="977" mass="111441" checksum="EB8F7DD51127CA50" modified="2022-01-19" version="1">MATLEFEVKENELDDVSSKSPNGKRNVVVCRPAHIAFVILGFCTITTAVALMVYYIPDRTQLEGTKIPGDGSKPTTSFYTTAPYAQTTDQTTTVINERQTTEPKPTEDPLMVGRLPGTVSPQRYLLNVRPFLYEDDAPYSTLNRSYTFDGWVNIKVECVVPTEEIILHSHTLTVHGTPSVTGLDTADSRQLLDHFTFDRGNMFLVLKLKESLQLHKNYEIQIVYTGLLDSEIRGFYVSKYITSDNRERLTATTQMEGPHARRVLPCFDEPSFKASFDIQIEHRYDMTALSNGLETKTIKLDDHWHRTYFKRVSAMPTYLLAMVVHDFQNINGTTDDGCLVRVWIRPDYISKISTALDFAMRLQTYFNSFLGMKYPLDKLDHIGITIMGGAMENWGLITYEEKLLIDHADDLTITHEISHQWFGNLVTPEWWDDLWLNEGFATYYQHIGIDFLNSGQEEYQKFYLDTMERAFTFDTNYMIIRPLKDPVSSDIDDIDNQIVLFTYVKGGSIVFMMKHFLADGVFEKGIRNYLKERAYKNANIDHLWEELSYADQDVGKHNMKRIMDSWTLQPGAPLVTLNRTGDTVLATQRRLYTGFPPHPGPFSERYYIPLTWVHKSNSSSPTTVLMEPDNEETIVHLEGASADDWYLANFLQTGYYFVDYDEENWLRIVEQAERDPNVFTFQNQLGLIRQVRKLEIAGIVPTDIAYSLIDALRNTSLGTREAALEGDLLRLSLLRGQKSQKAIERRILDDINFLYSEEGWHAATTIDPLSSSWLARKHRLDITSLACFYGNDDCVSKATALFKEIMENPFKNSVKPVFRHLVFCNGIRYGGQVEWEFGMRQMRGATMERERTRWGTALTCSANATALTHYISSLDGSSDDVNVFKVITALADNPIGGDMAWDYIKKNWGSLLSKSTDAHSASDLLLSVTAFFNTADELQELLDFGKGRDFGRLQQAFDLAVMSVNNNIGWVAKLNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW65</accession>
    <name>A0A8B7XW65_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110976287</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085109.1">
        <property type="nucleotide sequence ID" value="XM_022229417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XW65"/>
    <dbReference type="GeneID" id="110976287"/>
    <dbReference type="KEGG" id="aplc:110976287"/>
    <dbReference type="OMA" id="TIEAPTC"/>
    <dbReference type="OrthoDB" id="10072175at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022085109.1"/>
        </source>
    </evidence>
    <sequence length="620" mass="67456" checksum="FD5EAEFCC2166CCE" modified="2022-01-19" version="1">MMATVTEEVGSPSRSDDNAEDGTKNKGVSSNDEAGGTDSETTKEEEGEDEAEIMVCSSLKLDHRLQRMLFQLEDEENADQAAAADAQSLSQNLVKFKDDLCGWVPDPSVQYRRPAAEKPAPRAGGRTGTKPDAASAPSRRLLNCRNQYGHSSQQTASNPDYEFKHYSNYRKYCEQYRRYNTCGGPLQKLTQSALGGRPRTIYYAGEATAEAGVEVVHSNAGRSSEEPFSRSGPGVGGQVLRRARVSEKPSTTSQPIISYSEISVNSPRYNLMSEQSQRKARALQYYPNGLEWAQHPDPSPGYSPQRSGASLGKHPAAGAQPPGQWNVEMNEQTLTVYTSKPPGSLPAPARPATPPKPHLPFFPSQQPLRQLHKARASLTPPGLNPANDPLSSGYALDRSLGHPAGYSTGISRNPVPHRDFYSQLMHAAHCLSLAAKSPKDFDFELPRWPTCTSHNENSKCTLNPPQYTSHLEKPPTGSPSTSSPYTRTMQVQMTGRAVTASPTSTHHSSGSTSRPCQQQHPLHQSAWKSSTHPLGNPTSATTETHYITIEAPTCSPFDVTRSAAKQARRAADEDAGASKAASYRVTLKEKAVVPDIKEKTSVDMVADANRPLAVCEVTWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XX19</accession>
    <name>A0A8B7XX19_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Atrial natriuretic peptide receptor 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110975994</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084585.1">
        <property type="nucleotide sequence ID" value="XM_022228893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XX19"/>
    <dbReference type="GeneID" id="110975994"/>
    <dbReference type="KEGG" id="aplc:110975994"/>
    <dbReference type="OMA" id="RCTPSSM"/>
    <dbReference type="OrthoDB" id="1890790at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF8">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Receptor ligand binding region" evidence="8">
        <location>
            <begin position="55"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022084585.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="39978" checksum="F5716469E81FACA5" modified="2022-01-19" version="1">MIPGQSRMIVMFVGILQYARLQISSLELQSDAREIRLGLLLEIGGREIFDRVRIQPAVDIALETVRRRVDTGAYLNFSFTYEFQSTGTRCTPSSMVAPGIASDMFYRRGVRVFLGPGCSFQCKAVADLAAYWNVPVLSGASTSGDLDNKGQYTTLTRTAFLMGVMGHFSVALFRKWSWTRCSIIWDDVSVWKLITVSIRSRLEEANIYVHPVVLGLQESTQDALDAAARRGRVILVIAPVDVVRDIMIKAYQAGYTSGEYVFFSVHLINNRWRFGDSSWQRGDEFDIEAKRAFEALMTFRLHEPTSDEFQDFQKELELRRISGNVTVNENGDRDADYSLWDMTDTVNGDMSACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XX29</accession>
    <name>A0A8B7XX29_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Charged multivesicular body protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084595.1">
        <property type="nucleotide sequence ID" value="XM_022228903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XX29"/>
    <dbReference type="GeneID" id="110976002"/>
    <dbReference type="KEGG" id="aplc:110976002"/>
    <dbReference type="CTD" id="51510"/>
    <dbReference type="OMA" id="GVKQMQK"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022084595.1"/>
        </source>
    </evidence>
    <sequence length="219" mass="24712" checksum="F20DEDA6F8C93773" modified="2022-01-19" version="1">MNRLFGSSKPKAPPPNLTDCIQNVDSRSDSIEKKISKLDAELKKYKDQMKKMRDGPAKNMVKQKAMRILKQKKMYENQCDNLRQQSFNMEQANFATQTLKDTKTTVDAMKVGIKEMKKEYKKVDLNKIEDLQDDMADMLEQADEVQEIMGRSYGMPELDEADLEAELDALGDDFLMDEDTSYLDEAISAPSAPETNPGAESVQDGVPVDEFGLPQLPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXQ2</accession>
    <name>A0A8B7XXQ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GTP-binding protein Rhes-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110976239</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the small GTPase superfamily. RasD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085032.1">
        <property type="nucleotide sequence ID" value="XM_022229340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXQ2"/>
    <dbReference type="GeneID" id="110976239"/>
    <dbReference type="KEGG" id="aplc:110976239"/>
    <dbReference type="OMA" id="CKASRGV"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000475">
        <property type="entry name" value="GTP-binding protein Rhes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052236">
        <property type="entry name" value="Small_GTPase_RasD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46149:SF3">
        <property type="entry name" value="MIP08469P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022085032.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="32069" checksum="36F34020BCCC8314" modified="2022-01-19" version="1">MCDDSVLVLESELNTPAKNCYRLVVLGSSKVGKTAIVKRFLNGQFEEQYTPTIEDFHRKIYKIKGEVYRLDILDTSGNNPFPAMSRLSILTGDFFLLVYSIDSMESFQEVRRLRQQIIDTKRSRKGTKAVPMVIAGNKTDRNEHREVTLEEAKRAFSSGRRVTCHELSALDDSNIDGVFRALFENARLPSEMAPSMHKKVAAATSTNLNSGTSPRGLSLRRRISDACGVISPNARRPSLRSDLMQVRTNVLREEHHHNDDEYEDETEGDETASGGSTKKRACLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYF7</accession>
    <name>A0A8B7XYF7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SH3 domain-binding protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110976386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BP5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085292.1">
        <property type="nucleotide sequence ID" value="XM_022229600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYF7"/>
    <dbReference type="GeneID" id="110976386"/>
    <dbReference type="KEGG" id="aplc:110976386"/>
    <dbReference type="OMA" id="YHEARIK"/>
    <dbReference type="OrthoDB" id="446789at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007940">
        <property type="entry name" value="SH3BP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19423:SF1">
        <property type="entry name" value="SH3 DOMAIN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05276">
        <property type="entry name" value="SH3BP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="429"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="456"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022085292.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="68578" checksum="AE38F8BC4D8995BB" modified="2022-01-19" version="1">MEEPDQGGTRLDPRIKGELDKLNSTSEEINRLEKELDDARQQFRITLTESSHKLNDAAKRCGKSVKKAKPYHEARLKAKRAHEKVQEAAYAYQRAVGMVRAAKETITIAEETSMQGNKKREFDSALQEMLNHATVKLNMAEQEKVGGQKEHQQLSKAYVKSLAKVEQLAKKLRKSIAKSAAYYDLRDAFYSRLENLKESVENRQKLLAKCKKRYREALRNLERISEDIHHSRQLQIEASPSLQERSAGVGAESETEPGRNSDEEDDLFTSTEGGQDEHGDQEQNVPVRGAEGGAGTSRHSSSHSSSPEDGDPQSPLLTEHGLPTLSRKIQREGSDPDFYKPKSAIAKLPGILPEEQEVIEATYRGYRSFDSELTQEEVTALQQTLPSQARGSGTPVIMIDSPEGVTGELEDEGSDEDELEIYEPEEIEMSEFANEGSIGSDVGEGENSVEMKAFEQETQLNGEVDQTSLSESSEGDRDMEEILSKANLLQDAAGNSELSKPEVSLSDDSQLEGVEDGREGSVEARPRSMSFGFEKTLLDEDHFEKPDLLPSPIQKFQMSDLDRPSSPALFQYRALEHKQDVRQADDNSAFTYTPVVSNDDAATTNNNQDAKNDETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYX8</accession>
    <name>A0A8B7XYX8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 91-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110976202</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084976.1">
        <property type="nucleotide sequence ID" value="XM_022229284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYX8"/>
    <dbReference type="GeneID" id="110976202"/>
    <dbReference type="KEGG" id="aplc:110976202"/>
    <dbReference type="OMA" id="HIKKFHV"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001397">
        <property type="entry name" value="Datilografo, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000322">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001155">
        <property type="entry name" value="Zinc finger 30C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000671">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000912">
        <property type="entry name" value="Zinc finger protein 660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000710">
        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000099">
        <property type="entry name" value="Zinc finger protein 79"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF390">
        <property type="entry name" value="ZINC FINGER PROTEIN 37 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
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            <begin position="68"/>
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    <feature type="domain" description="C2H2-type" evidence="13">
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            <begin position="96"/>
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            <begin position="127"/>
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    <feature type="domain" description="C2H2-type" evidence="13">
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            <begin position="155"/>
            <end position="182"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
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            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
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            <begin position="239"/>
            <end position="261"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
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            <begin position="265"/>
            <end position="292"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
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            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="612"/>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="784"/>
            <end position="811"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="812"/>
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    <feature type="domain" description="C2H2-type" evidence="13">
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            <begin position="840"/>
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        <location>
            <begin position="868"/>
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    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="896"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="434"/>
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        <location>
            <begin position="715"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="12">
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            <begin position="482"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="766"/>
            <end position="778"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022084976.1"/>
        </source>
    </evidence>
    <sequence length="962" mass="108779" checksum="20611B6CE07EECDF" modified="2022-01-19" version="1">MASTAQTVDSTSVYICGMICGRTFLNSKEFEEHQASHTGQHTLLATVYPDRFNPDGTMRMTGPPADAPYCRVCGKVFAGQNHLERHLRVHTGEKPFTCATCGRAFTQEASMKRHQQIHTGEVREKKHRCNICDKAFLYNSQLKEHQRTHTGEKPYKCEYCGKAFTKQTLVNHHRKIHTGDKPFVCDICNKAFTQLSRLRVHKVTHTTERPFVCDICSKTFNIQSNLYAHRKLHSLEKTFTCNVCQRQFATKRGMRDHRNTHNKPFLCEDCGKAFALSQALRKHRKKHAKVQEEVQASDQKESSEDYCDLPEMLLVCAVPRNMRKSFTCGSCGVTFSRRTSLRGHIKKFHVGGKLFHCFICGSAISHVSVLETLLQANTEIEEFICESCEDCVQKQKRLIKELDVHSQEEIVVVVYNKGISESANIVSHCRDSAGVETTSPETDHVTDGQACNKHNTTPPEYKPELDASEKSPGANNSSKASPGRRGRFCHGGKAHSKGSFICKVCNKSFSLRGNLNMHQLVHTGEKSFLCDICGHVYARNQALKDHQMSHTGERPYLCSVCGKSYRHRKMYHDHQRTHTGDRPYTCGTCGKAFSTNTTLRQHHRIHSKEKPYMCGTCGVVFSRRTSLRKHIRKFHVARKLFHCFSCGTTISQAIVVEALLRAPSKIEEFICESCADRDQKRHIKELEVHSKEEIVVVVYNKGISESTNIVSHCRDSAGVETTSPETDHVTDGQACNKHNTTPPEYKPEIDASEKSPGANNSSKASPGRRGRFCHGGKAHSKGSFICKVCNKSFSLRGNLNMHQLVHTGEKSFSCDVCSNVYARKQALKEHQMSHTGERPYLCSVCGKSYRHRQMLRDHQRTHTGDRPYTCGTCGKAFSTNTTLRQHHRIHSKEKPYMCGTCGVVFSRRTSLRRHIKKFHVREETFNCESCGDAISQEKAVETLLVACSEVKIFYCQTCKKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y169</accession>
    <name>A0A8B7Y169_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Double C2-like domain-containing protein beta isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110976599</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Synapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085711.1">
        <property type="nucleotide sequence ID" value="XM_022230019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y169"/>
    <dbReference type="GeneID" id="110976599"/>
    <dbReference type="KEGG" id="aplc:110976599"/>
    <dbReference type="OMA" id="FFFAMDA"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017158">
        <property type="term" value="P:regulation of calcium ion-dependent exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061669">
        <property type="term" value="P:spontaneous neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04035">
        <property type="entry name" value="C2A_Rabphilin_Doc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08384">
        <property type="entry name" value="C2B_Rabphilin_Doc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000032">
        <property type="entry name" value="Double c2-like domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041282">
        <property type="entry name" value="FYVE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043566">
        <property type="entry name" value="Rabphilin/DOC2/Noc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047022">
        <property type="entry name" value="Rabphilin_Doc2_C2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45729:SF6">
        <property type="entry name" value="RABPHILIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02318">
        <property type="entry name" value="FYVE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RabBD" evidence="12">
        <location>
            <begin position="49"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="11">
        <location>
            <begin position="97"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="393"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="532"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022085711.1"/>
        </source>
    </evidence>
    <sequence length="676" mass="75052" checksum="DFDF8903D87BC0A1" modified="2022-01-19" version="1">MPINGAATNMGEFVGGSAVDRWTCPNDRQLALRAKLGSGWSFHTSASKYKKSDTLSREEQETILGVIERADKLEVAEQERIGRLVDKLENMKKNALGNGSGKCVLCGDEFGLLGASPLTCHDCYKAVCTKCGVDTTNSFKHPILLCKICSETRELWKRSGAWFFKSLPKYIIPEKKVDQSRLQGWRFETRKSGRKSTTGRVNNTWSKADVSESESEYSSSEDEVSIGRKRKPKRETNTDDNISIGSKNGMASSIYGNNYMAGSRTSIGSAGWYGGASTTESSHDAARDESDSERSTLGDNEHSRTSSVRSLTSTNISVSDLSRTSSVRSGGSSGPVIALKPDHEEEDMDRAFTQFSSALQTSAAPPTSVGSSFDSQDYGLPDALGSSPDEGSSLGTLEFSVLYDGVNNALHCTIHKASGLKAMDSNGMSDPYVKLHLLPGATKSTKLRTKTVHKTLDPKFNETLTYYGITDDDLMRKTLRLSVLDEDKFGHNDFIGEYRLPLRKLTPHTTKNMSVYLEKQMPLEKDDELMGERGKILVSLKYLKERQQLLVGILRCAGLAAMDANGYSDPYVKVYLKPDSGKKTKHKTATKKRTLNPEFNEEFFYDVAHNDLAKKTLEITVWDKDIGKHNDYIGGIQLGINAKGERLRHWFETLKHTDRRFERWHTLSDEIFAGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1Q4</accession>
    <name>A0A8B7Y1Q4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 11">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110977362</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 11"/>
    <dbReference type="RefSeq" id="XP_022087098.1">
        <property type="nucleotide sequence ID" value="XM_022231406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1Q4"/>
    <dbReference type="GeneID" id="110977362"/>
    <dbReference type="KEGG" id="aplc:110977362"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048776">
        <property type="entry name" value="HAT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21183">
        <property type="entry name" value="HAT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="16">
        <location>
            <begin position="14"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="178"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Histone acetyltransferase type B catalytic subunit C-terminal" evidence="17">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="13">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="14">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022087098.1"/>
        </source>
    </evidence>
    <sequence length="407" mass="47944" checksum="090387121CC7451F" modified="2022-01-19" version="1">MADFTLMKNVLEEYVCDANQVIELKLVRSEADVFDDGKIFHPEFTHQLFGQNENIFGYKGLRVQLFFTAGRLVPYLHMTCTEKVNAKLFDGVQADSVLKTVIDKLEIKPMDNLDKFISVISDDASFQPVGELLHAYSVEGEGPTRNFEIYTNDITAPGFREYHERLQTFLWWYIDAASYIDMDDEKWVYYTVFEKYIINGNKRYAVAGYATAYRYYAYPDMTRPRISQVLVLPPFQRQGHGVQLLQTMYSHFRNDTKILDITVEDPSEDFVRLRDFVDCRDCMKLPAFDPANLTKGFSAEMEKQALEKLKLCKKQVRRVYEILRLRATNTRDRAEMKAYRLDIKRRLNIPFQKQKSDQEKMRRTLKPEELAATMQGTTLQERHETLENWYQELMTDYRRVLDRLALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1S5</accession>
    <name>A0A8B7Y1S5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Symplekin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110976711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085906.1">
        <property type="nucleotide sequence ID" value="XM_022230214.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976711"/>
    <dbReference type="KEGG" id="aplc:110976711"/>
    <dbReference type="CTD" id="8189"/>
    <dbReference type="OMA" id="NVRYGIM"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="125"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Symplekin C-terminal" evidence="6">
        <location>
            <begin position="919"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1180"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1378"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1412"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1412"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1432"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1493"/>
            <end position="1508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022085906.1"/>
        </source>
    </evidence>
    <sequence length="1526" mass="173508" checksum="F91827A3D6338689" modified="2022-01-19" version="1">MDSERSRRSIASQYFMDEDSTTADMAEGINTSDRVIDLINQTHLLTKDSQKIANLKHVQELIVHKDPTLLDNFLDEVLQFQHDKSADVRKFVVGFIEEACKKDNDMLCSVIPHLNMMLSDSAQHVAVIKKVILCSMQLYKIALKWLVNARTFGEEMEAVWDQIQEIKRKVFIMLDSENDGIRTHSTKYMESLILVESARVAGSEIPKKPEADISLDQIPEEHGLLKREELEKDGLHAFELLLDLLASPSITSVNLMACMGSLTTIAKQRPQFMARVIQAFETLHVNLPPTLAKSQVSSVRKHLKMQLLNLLKHPSSVSLHSNITTLLTDLGASEAEISKHMPKVRESFKRPRPADDEGSSNSKKPKTTTVKTIQQVMDEDEMGRETPLHPTLLPSMPSTSKATIQAPAKISVVDLLAEELTPLLQNVENVANLVLISMVTLPETMPPQFQASYTPIAAAGTDSQISHLARMMSSQFATAGIKPQNMEMLEQEEEAADKENKSAVTQKPTGIPVLGEAEEDTGRKKSGLSFQAPVGVPKPRARMKQFKLSDVTVPLEQMVANKLVSGAVSRIITSEKMSQQGGASQARIKILVGLVSQFSEMSQQGGASQARIKILVGLVSQFSGDLFPMLKDHVLEDLRSRSELAFAWLYQEYSSYQGYMPRYLDQEVSMNRYDKLLCAMLMALLDRPDQRDGLFTRLVMEAPVITERAVKVIRKFCEDETHFFTGMHALRELILKRPADIQRYLQELLELTFHERTEVRSQATQYVKRLYERQDLKETIEEFASKCLHYLLSDVPNPSLVSRTSEGGEGGSDWTEASIKLCLHLYLALLPSNHKLIHELATVYVATSALIKRTVLRVLEAPVRGMGMSSPELLLLVENCPKGAETLVTRMLHILTDKAPPSQDLVKRVRDLYLKRVSDVRFLIPVLIGLEKKEVIAALPKLIKLNPIVVKEVFHRLLMSHQGDNSAGQSPLTPAELLIALHNIDTSKCDIKSIIKATSLCFNEKAIYTQEVLAVVMQQLMEQGTVPTLLMRTVIQSLGMYPRLSGFVMNILQRLIVKQVWNLPKVWEGFVKCCERTKPQSFQVLLQLPAEQLKNVFEMSPDMRAPMLAHVQTFTPHQQAHIPPPIMTVLETDPLAEKKKMEEEERKKREEELRIKMEAEEKQKEEERLLQEKLAEERRKQEQLKKEAAEKAAKEKAEKLKAQREAEEKKRKEAEEKLARERQEKMRAEQEASLKAAREAGERVAREARERREKREAAREAGIKAAMEAKEKKEKMEAEERARRQEEQQKAALARQEEMEKKKQEEEQKKQEEIKRKEEEALKREEEERRQQEEQKSRQEEENKKREEETLKQEEEKIRQEVEAEKKRQEELEAERRIKEQIQEDQEMQEMVTVKQEPDELKEFEAAAHQEMPLKIKQEKPDQEAQEATVDTEFKIKKEVEDYPEQEAVENPFQETVEDESQSSNPVASAELESEDTGDGSVQSEMPSPAGRGRGRGRGGRGRGRGAKKTATPSPSGTRKSTRKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3I8</accession>
    <name>A0A8B7Y3I8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Doublesex- and mab-3-related transcription factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110977710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087749.1">
        <property type="nucleotide sequence ID" value="XM_022232057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3I8"/>
    <dbReference type="GeneID" id="110977710"/>
    <dbReference type="KEGG" id="aplc:110977710"/>
    <dbReference type="OMA" id="QRECQWS"/>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF53">
        <property type="entry name" value="DOUBLESEX-MAB RELATED 11E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="7">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="5">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022087749.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="51103" checksum="EEE6B0ADE0DBF731" modified="2022-01-19" version="1">MDNYMVPNLTLHVHQDESHLGISSPSPTSAEADSRSGPRLKAGKMDPPSRPPTTRKVLRTPKCARCRNHGVVSCLKGHKRYCRWRDCQCTNCQLVVERQRVMAAQVALRRHQATAEDAPVAPGKEAAGNGVVAPTRKSVCGAGKGVNTSGGSRKIHSSRGQGHRATSVSKDILEGCRSKGSRTTAPSTSVSARPVIFLPPSVSERMRKRRAFADKDLETTMLQRECQWSLMYAAQASLSRLPSSVNRQYHPHHRTPGGIDAVREPPDHTAGFLRRLFPSYSTTALDAALRGSAGNLRLAIEKLVTAYAATPTCGPTAHPLLSTGVNLETTPSLPWNLSPPGSKIYEEDDGRTNSAHFEWGSILPVNKPIQKFSINRIRGEGSVSAFSSVRRAENWASDSRSRLGSVESENDYSQDLSADLAPAGDRKRDRLDDSNAQEICRNASLTKRFAKTVSTKRLSFSVDSIMGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9Z2</accession>
    <name>A0A8B7Y9Z2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein SSUH2 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088516.1">
        <property type="nucleotide sequence ID" value="XM_022232824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9Z2"/>
    <dbReference type="GeneID" id="110978110"/>
    <dbReference type="KEGG" id="aplc:110978110"/>
    <dbReference type="OrthoDB" id="3355217at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052789">
        <property type="entry name" value="SSUH2_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088516.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="55686" checksum="52840BB397565ADD" modified="2022-01-19" version="1">MAQQGYPPPGAPPPQGYGAPPPQQGYGAPPPQQGYGAPPPQQGYGAPPPQQGYGAPPPQQGYGAPPPQQGYGAPPPQQGYGAPPPQQGYGAPPPQQGYGASPPQPPQPPGAVQQGSQQQAWTPNAVPEGAAPYKFDNAAESDPEDDENATEGDEKNPDVTSLEPVPGYETVAFFDGPPVPPPAYEPPSEENRPQEVFDSKEGIGEEAVRAAILAFVDKHCCYGSRPAKNMTISKIIPTHALHYQLETFNEARSTSRKFKPYSGGFVDGPENGPAPPPWSIACKPDQLFFTHKKNLEVPHTSIIKICHRCCGCGFVMCGRCRGRGRVRCSSCHGSGRRTVHRDGKSQRVSCTWCHGSGRRRCTRCGGDGRVTCPTCTGYRQLRHFILLTVSYVNNLEDYILERSDMPDELIRNVSGQTVFQQTLPFVWPISQYPVQEVNQNSIRLVDKHRSAWPNALTLQQRQTLRSVPVTEAHYDWKDISTRFWVYGFEHEVHAPDYPHQCCWGCSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA74</accession>
    <name>A0A8B7YA74_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium-coupled monocarboxylate transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110979011</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090148.1">
        <property type="nucleotide sequence ID" value="XM_022234456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YA74"/>
    <dbReference type="GeneID" id="110979011"/>
    <dbReference type="KEGG" id="aplc:110979011"/>
    <dbReference type="OMA" id="AWYACAF"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022090148.1"/>
        </source>
    </evidence>
    <sequence length="632" mass="68164" checksum="77284A1ABB6241CA" modified="2022-01-19" version="1">MAGPEDAANFGVWDYVVFGCMLLISLGIGFFYGCTGGKQQTAAEFLLADRNMNPIPVAMSLVASFISAITVLGTPAEVYIFGSMFWLFCFSYPVVGLAVSRLFIPVFFRLNVTSANEYLELRFNKAVRVSATITFFLNMVFYMGLVIYAPALAFNAVTDVSLWGSVLATGLVCTLYTTVGGMKAVLWTDVFQTCVMFGGFIAVIIEGTMRLGGLGNVWRIAEEGGRIDFWNFSFDPTIRHTFWSIVIGGSFTWSTSYGVNQAQVQRYITTGSVKRAWVALGLAGAGMVIVGSVSCLSGLVMYSFYADRQCDPLTSGKISQTDQLIPYFMMDLFGRIPGLPGFFTSAVFSAALSTVSSGLNALAAVTAEDLVKPCFPHISEERYALATKGIAFGFGLLCVLLAYITSLLSQGILQLALSLFGMTGGPLLGLFSLGMFFPWTNSKGAIVGLLAGLTFAFWVGIGAIIYPPSIYRPPLTIEGCNLTTSITTPSPLLMTTTTIAPETSPIGELYSLSYAWYACAFWLVTVVVGLLVSFLTGATKRQDIDPVLRSHCVDGVYCCLPEVIKKPLRCGDEKPDYTEKDQGAEIVEVKPGLTTYAADIDNDDVGKATFATEHQSGTGTENGLDNEVFTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAY0</accession>
    <name>A0A8B7YAY0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ciliary microtubule inner protein 2C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110978763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CIMIP2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089717.1">
        <property type="nucleotide sequence ID" value="XM_022234025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAY0"/>
    <dbReference type="GeneID" id="110978763"/>
    <dbReference type="KEGG" id="aplc:110978763"/>
    <dbReference type="OrthoDB" id="8181742at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052329">
        <property type="entry name" value="CIMIP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018902">
        <property type="entry name" value="CMI2A-C-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34924:SF1">
        <property type="entry name" value="PROTEIN FAM166C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34924">
        <property type="entry name" value="UPF0573 PROTEIN C2ORF70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10629">
        <property type="entry name" value="CMI2B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ciliary microtubule inner protein 2A-C-like" evidence="8">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022089717.1"/>
        </source>
    </evidence>
    <sequence length="203" mass="23756" checksum="3750A20BF6F94C4E" modified="2022-01-19" version="1">MSRSAGTLQTTHQATYIPPRMMPGYKGHCPTTKFDYGETYGNATAKYFQDYRSETLNQSKSNYARGGQFPTVYTHNPDLVIHARDRTREQWRTAPKYELTNVNYDRKEEIDKFDKLAQDHRQYYKDRTGTVQRVNEFLIPKSAEDMYRQDLKSAEEEVDVEAEAKLKKMLNQPVMRTPKTTSTNSRTSTVRDRAMRDVVFESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCY5</accession>
    <name>A0A8B7YCY5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-1 adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110979059</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090245.1">
        <property type="nucleotide sequence ID" value="XM_022234553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCY5"/>
    <dbReference type="GeneID" id="110979059"/>
    <dbReference type="KEGG" id="aplc:110979059"/>
    <dbReference type="OMA" id="RFSMARC"/>
    <dbReference type="OrthoDB" id="6155320at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249:SF372">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="32"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022090245.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37464" checksum="C879FDB61184D0CD" modified="2022-01-19" version="1">MGNNTDEEPLSPFLIALRTCFVAIVVIMIIAGNALSIAVTRSMPTLADSTKLLMVSLAAYDMLTGVISIPNVIASAFNTWPFGKLYCSINGTVDATCCCMSITLIVLMNAERYIAVTMPFRFSTLCSKQRVITVVLTASIVSLALQICLTYFKEIKIQFEAVLVCDVGFNGTIYEISVLFFLVIIPLVVLTYIYLKLIKLSQNHVVMLNKSKNVENENSFLENKALRAFLVVTILFAICWTPLRVVRIIAAITGETQPTWLTFTAKGFAVCNSFFNVFIYCFFNRSFRQATTRLMARYFLCPKASVAPVTPLTIRDETMKPIVRRKGKPTLISVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YD20</accession>
    <name>A0A8B7YD20_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Paramyosin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091153.1">
        <property type="nucleotide sequence ID" value="XM_022235461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YD20"/>
    <dbReference type="GeneID" id="110979557"/>
    <dbReference type="KEGG" id="aplc:110979557"/>
    <dbReference type="OMA" id="RKATEMH"/>
    <dbReference type="OrthoDB" id="2130396at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091153.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="57165" checksum="3C214548A709E6CB" modified="2022-01-19" version="1">MSSISSMARFRNPTKSARDPGFSSTLKRTSSLGSLNKRSSANLAPSFNASKTSPGLSEEYSNLEAEYIKNLQQQIYFLELEANFLRDQARKATHLQPKMTEEAGRMLDTLKDLQSTVDGLHLDIKRKESNLDMVNSEKERLDGRLKLLQDTHNREKKLLVEEIVQLKKQNEMTLREIAQKEEQIFDARKELDKGSTSLTSAEQKIRILTAQVDQKSDELRHTQLALEDKRAELLKVQTQLQELEDRYYSSTASIQDKAVEEFRNEIRVMQHKMKETELNAQQDRYLKNKMSDDIANLVKENALLGTQVVELQKQLDRERSLRESRDTRHASNITELVTVRDKEKQLKYELDKAREELKYERDRVQHLMNQLAKQEQEHVTSNLSQNTLRSRLAELEGRLSGVEVENTQLRRDKMLLVDHVSELQKQVAERDQEATRMQNHMHTMEGTLAGLERRNKQESSLQSQRWGEFEKMAESMKNLSKSMTARSLTPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEF3</accession>
    <name>A0A8B7YEF3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-beta-hydroxybutyrate dehydrogenase, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110979458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090957.1">
        <property type="nucleotide sequence ID" value="XM_022235265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEF3"/>
    <dbReference type="GeneID" id="110979458"/>
    <dbReference type="KEGG" id="aplc:110979458"/>
    <dbReference type="OMA" id="PHERYFP"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF36">
        <property type="entry name" value="D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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            <dbReference type="RuleBase" id="RU000363"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022090957.1"/>
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    <sequence length="390" mass="42896" checksum="8A819A82FFDA80A3" modified="2022-01-19" version="1">MQRIKIGRPQYLLYLLHLHLRKMAAASLRKVAVFALCLGSSLILIVPHLGHELLTKSVGCFLAVGLSYLISSWYTGGKISSVRGKAVLVTGCDTGIGNALARHLDSLGFRVFAGCLFAEDSAALRLTAECSKRLEVVQLDVTSDLQVSRAVSYVRDSLSATGDVLWGVVNNAGMACWGEVDWVSLDRYKRLAEVNVWGMIRVTKAFLPFIRNCGGRVVNISSMLGHFSAPGCSAYCITKYGVQAFTDSLRNEVNKFGVSAVIVEPGNFSGGQSAMFTRENMFKDLDRAWSEAPEEVRGVYGTDYFEAFKNALVNASHYTATTSLSLVTEACASALIDANPHERYFPGNWTSKLTVLIFCFLPASFTDVLFRVYQSLFLVKVKWAKSKNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFU1</accession>
    <name>A0A8B7YFU1_ACAPL</name>
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        <submittedName>
            <fullName evidence="4">PiRNA biogenesis protein EXD1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090521.1">
        <property type="nucleotide sequence ID" value="XM_022234829.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110979224"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:PET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:3'-5' exonuclease activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
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        <property type="entry name" value="piRNA_biogenesis_EXD1"/>
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        <property type="entry name" value="RNaseH-like_sf"/>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46628:SF1">
        <property type="entry name" value="PIRNA BIOGENESIS PROTEIN EXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="2">
        <location>
            <begin position="10"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090521.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36923" checksum="E724AF34A3E44A55" modified="2022-01-19" version="1">MASSYQGPSYDLIDKASDIRPALAKLREGVTSSPFLAVDCEGESLSRKGQLSLVSVALPTHTYLFDIKTLGAKVFDEGLRDLLQDPDREKLMFDCRSDSDCLWHQYHVKLTNVLDLQLLQIIYRETNPEPVQDDKPRQVSWPGSRRQPMATASRPPINVQPVLRSFLRCLELYVDDKDLTTAKAAGKEKMEREGTAVWMKRPLEASLLAYAAADVQGFLPLYRALRGAIANPDKKERLRKGSQNFLDYLRSRSFRTYDDYERNGFLPWRILPASGHERPYTPEVYCKGCKRAFPRQDFFALHIRRGIQHCPVCRKIYGLQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGF6</accession>
    <name>A0A8B7YGF6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="6">PARP</shortName>
            <ecNumber evidence="6">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110979859</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="6"/>
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        <property type="nucleotide sequence ID" value="XM_022235980.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="aplc:110979859"/>
    <dbReference type="OMA" id="GQLCCKK"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02907">
        <property type="entry name" value="Macro_Af1521_BAL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12547">
        <property type="entry name" value="RRM1_2_PAR10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd01439">
        <property type="entry name" value="TCCD_inducible_PARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000008">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052056">
        <property type="entry name" value="Mono-ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034464">
        <property type="entry name" value="PAR10_RRM1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057051">
        <property type="entry name" value="PARP14_RPM_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453">
        <property type="entry name" value="PARP/ZINC FINGER CCCH TYPE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14453:SF67">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23222">
        <property type="entry name" value="RRM_PARP14_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1136"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1376"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="1604"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="8">
        <location>
            <begin position="2005"/>
            <end position="2200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="171"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1355"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1569"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1587"/>
            <end position="1596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022091672.1"/>
        </source>
    </evidence>
    <sequence length="2200" mass="242650" checksum="C989A64D2C6178DF" modified="2022-01-19" version="1">MDTSRSLVYAGLPRNEFTECKLGELADKLWIYFQRKNVSQGCDVDSVSSIESDTSGKLWMKVIFSEPSGAQHVVSKSQHELKVDGWEIIPLEVRKSFPSDESSQSDDNESFDYVDAVDMDDPKGALASDSHGKTASATHVQNQSASQKGFPSSQQSGLSRNAATLNLTAHAASPKTEETPSGPVSTQRASNSGGDSSTQSFKDNTAGGEGSYQDTDDADLYGPDPKEPCIKNEAPTMRTSSSEEAVSNYTRGKGSETQEQGSFQAEAVLSAGTSRNHQPVDGKQCQFTGSGKKQNGSSKRSEPKIATRQNDTGKQDGHVPQEMTKSSDGPAVPSGHTSKRKRNRGKAKKQSPKESPEEKRTAPERQENNEVSSHRDDQVQEGDSPNGQQVEEEQEEKFVEVTGFSPSSEEMLKMHFENSRRSGGGEIETWEHDVKTGAIRLTYQDPSLVSKVIAKQHKVGGATLSVRLVVKKKPRPRPVNKRCLLLKGIPDECTSDLVAMFVENRCGTEDFEIRYGEMPGTALCTFNEDIEDLENVIKKISLKKLKGLYVTAEKVHESDCILVQGVSSRESLEMIELYFDNKKKSGGEGVRDVQQGPEETQAIVFFDDWKVIRDVLSKKGPHKVGGVELSVEEYHECLGRISPLDVPTPHIPKPVSVQVPQAFMEFIFGQKGQHTRKTLVQKLSDVKASLKWPDGDDKTVARLEPLPEDGQRQSSWLKWPEVAPEALKDFLNRCKSSRIAIPVPLWKDTVAKIDQHGTNGFSVELDATQHIVHLVGVQQDVDRGANDINKIIKELKEKAEFEAQQTIQDIKLTAEKLQPFIICGIKEKIENAYPDLKITITAMQDKIMLRFEGTRKNVQEAELLMRREMDSLECIEFKAGKNKVQFVHILKDKIHEILGSQGIRAACKGSDDGKIIISGATRKDATQAKAYVDHEIVDDVIPIRGKATLDVLQNQNGQKLLDSINNQRFVMAAISKNGGSVVELAGFKTNMDETKKKIDTFLKDNVIMMRLIKANKIKIRLITTFHGADLVNLEKQNAPNRVKIQPVMSGHTKGFTIQGNEEGLEAASQFLTSLVARIKEQPYPVSKTGMAQLFREDKGRKFLESLEAEFQCVISENVEEDEEEVAGSGGALMTTEVLCRFSLPNGFILKVCRGDLTRQKVDCIVNAANVELKHVGGLAAAIVEAGGRVIQTECEQILKDFHRRELFVGEPVYTSSGSLPCKKVIHVAGPKWPHGKTARPKTDEEPSFEEHLLYNSVLACLKLANQLKMKSIAIPAISTGVYGFPVELASRQILNAVAYYIQNTLNPILTEIHLTNNDQPTCNVFRQTVMNRFKQYQEEEVVGFDVDVGSAGASWDTPVTEDDTPVPAPAPKFTASGQNTLTTNEGINITLKKGSITNETVDVTVNTAGSDMKLNNGKVSQTILQVAGLSIQQECDALTATRGKIPSGDFIETGPGALTCKKIYHCVCAGYQPGVSEKALKKLILRLMEQAEQNEMLSIAIPALGTGNLNYPAGVTAQVMYESILEFSNLHPNGVLKDVRFVVYDKDASTIQGFEGEIQRLLTPGISRGATGYAPTGRSRKLKKPGSASTPTDRQSYSEIRRDHTGMLQTKIGSVCLQVGQGDLIKETTDAIVNSVGPGLDLQGPVSKAILAHGGSVLLDECQLQRKKEPKKLVYVTTSGSLQCNSIFHVVTPQTPEEIKTIVFKTLKQAEEGKLKSVSFPALGTGKAGQSVEDCANAMLKAVGEFAVQRKPRHLHLIRLVIFLPNMVSGFQDALHREVGTSYKKQKGWLSKGLDLAKSALSTLSSGTAAADELSEEESLQETIILNICAMDMSSIRKAVDKIDQFQSEEYMSEDRPDDHGMIGKMTDEHIAEVKAIEKKYNVKISCPRGKCVRVQGRVISVKDAHIQIQKMFTKMQKEELEAQRIELLSKQVQWKYSTPHGVEAYDPEVNTLIEDAYNSKRPSVTLNLEEGKVTIHFKDMQEVSRAGTLNVHRIDLTKVAAFEMPSNWIPMGQNEHFKMAPLTAGTNEYITVETQFNATMAGHQIQEIQRVQNKDLLMQYQARKAAMEARLGRPDVEKTLYHGTDETTSDKINKQGFNRSFCGKNATVYGNGTYFAVNANYSAQPQYAKPNASGVKHVFVTKVLVGDYTRGSQGMITPPNKPSHPDQQYDSVVDNANQPGIFVVFQDAQAYPEFLIKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH47</accession>
    <name>A0A8B7YH47_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110980306</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022092569.1">
        <property type="nucleotide sequence ID" value="XM_022236877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH47"/>
    <dbReference type="GeneID" id="110980306"/>
    <dbReference type="KEGG" id="aplc:110980306"/>
    <dbReference type="CTD" id="7398"/>
    <dbReference type="OMA" id="DENWIAS"/>
    <dbReference type="OrthoDB" id="10062454at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF905">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="87"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="413"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022092569.1"/>
        </source>
    </evidence>
    <sequence length="776" mass="85119" checksum="1DF5F164456279FE" modified="2022-01-19" version="1">MASCSSPPKKRPKLSLKFMRKDRRPVTDDDAVSQREGSARVRRNSAPNGQSSSTSSSVTTDPLSTQTPSSKEHQLEVSVRCPPPPFAGLQNLGNTCYLNSVLQALRFCPGFCPGLDRLVGAWERVTEQTRVEEGGGDEDPLTRCGQEMHFVLHLKKLYDKMSAKEADYISSPSSDTTISLSPDEVLETVRDLNPMFQGFLQHDSQELLCCLLSYVLDACQKLKKQLVKLRPPSPLLGQSHRAACIHSRDRDSPRSYAVPESGPCVRGGQEELVALAEDCRGTVKMENMTGMPRRNGKLDVNSSVCDQEAYTVTGEGDRCGDMKNGKATPRGRARNASNDSVMNSTTKSLSLDGKTNGNMVNGFNHSSPDSSETTKVCNQVHNASGKKKRLGKFRMAPSQQTLFDAFTSHKKEVLPPNGLRKDLENGTNGQGNGVDGKTNGLSESCELVDHGQTIHPGQTNESNKTKAQSAQPFPGSNSGDFTEPKMMPSRQSMVVVSQESPSGPPETGEMDEPTSWAKTTERDLEVIRGLFQGALLLRTRCNECENYSERREEFQDISLPVRSIPRCTRDEEDAGVPGVSPVDLSLSWAISEFACVERLTDDNKYFCEHCHHHAEAERSMLFGELPPVLTIHLKRFSALSGFLTADSTVSKVNDHLATPLSLCLSQWCAKQCQQLHCQYNLCAVVMHSGVSSSSGHYITYVRIPDCPLESYETADPGIGANSESSQPRWGKFDDEKVSLLTQQELAASVLHPVSGSGSAATPYLLFYRQVQEPDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH50</accession>
    <name>A0A8B7YH50_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Insulin-like growth factor-binding protein-related protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091725.1">
        <property type="nucleotide sequence ID" value="XM_022236033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH50"/>
    <dbReference type="GeneID" id="110979886"/>
    <dbReference type="KEGG" id="aplc:110979886"/>
    <dbReference type="OMA" id="TWNITGQ"/>
    <dbReference type="OrthoDB" id="10050438at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005520">
        <property type="term" value="F:insulin-like growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011390">
        <property type="entry name" value="IGFBP_rP_mac25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186:SF19">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034183074" evidence="4">
        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="171"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022091725.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="31388" checksum="53BFA536B65B3E39" modified="2022-01-19" version="1">MKTLRFLFWALVLLVLQEFTVSEEADKPEEKENAADEPSTEDCSCDAVICEVVSEDKCPHGLVNDTRDPCRCCKRCGNGEYQFCDPEELSAKELAEKEHNFGLCGKGLTCRANYGVPVGAKPEMICYCQNEQMVCGSDGETYETECRMNKVAFETGQTIGRKKPGMCEGAPKVVTPPNSVTNSTVGNVYLQCEVKGNPVPRIEWRKIGPDGPADFIPSGDSGNNRVAIQTRGGPEEYEVTGWLQIMRLEVEDAGEYECVGINDNGEDSGRANIIVVEKAKPIPGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHI8</accession>
    <name>A0A8B7YHI8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110980058</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022092047.1">
        <property type="nucleotide sequence ID" value="XM_022236355.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092048.1">
        <property type="nucleotide sequence ID" value="XM_022236356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHI8"/>
    <dbReference type="GeneID" id="110980058"/>
    <dbReference type="KEGG" id="aplc:110980058"/>
    <dbReference type="CTD" id="55644"/>
    <dbReference type="OMA" id="HHRSWVV"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="29"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="130"/>
            <end position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022092047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022092048.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="37113" checksum="4E65F491ED542F9C" modified="2022-01-19" version="1">MPTVIGFEGSANKLGIGIVRDGVVLSNPRHTYITPPGHGFMPRETAKHHQAHAIEILKKCMEEAGLKPDDIDCVCYTKGPGMAAPLISTAVVARTIAQLWDVPIIGVNHCIGHIEMGRLVTGSHNPTVLYVSGGNTQVIAYSQHRYRIFGETIDIAVGNCLDRFARILKLSNDPSPGYNIEQMAKKGKVYIELPYTVKGMDVSFSGILSYIENVAHKKLTAGECTPEDLCFSLQETLFAMLVEITERAMAHCNSNEVLIVGGVGCNERLQQMMRDMAVERGAVVCATDERYCIDNGAMIAQAGWEMYHSGYRTPLEETWCTQRYRTDEVEITWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHZ0</accession>
    <name>A0A8B7YHZ0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110980159</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022092232.1">
        <property type="nucleotide sequence ID" value="XM_022236540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980159"/>
    <dbReference type="KEGG" id="aplc:110980159"/>
    <dbReference type="OMA" id="KPHTEYA"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd14553">
        <property type="entry name" value="R-PTPc-LAR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000093">
        <property type="entry name" value="Down syndrome cell adhesion molecule, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000010">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000036">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000023">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000002">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase delta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000001">
        <property type="entry name" value="Receptor-type tyrosine-protein phosphatase F isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050713">
        <property type="entry name" value="RTP_Phos/Ushers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957">
        <property type="entry name" value="CYTOKINE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46957:SF6">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1394"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="33"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
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            <begin position="134"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="228"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="318"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="21">
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            <begin position="413"/>
            <end position="509"/>
        </location>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="510"/>
            <end position="603"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="608"/>
            <end position="709"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="714"/>
            <end position="814"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="818"/>
            <end position="911"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="913"/>
            <end position="1006"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="1011"/>
            <end position="1108"/>
        </location>
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    <feature type="domain" description="Fibronectin type-III" evidence="21">
        <location>
            <begin position="1112"/>
            <end position="1215"/>
        </location>
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    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="18">
        <location>
            <begin position="1482"/>
            <end position="1738"/>
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    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="19">
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            <begin position="1658"/>
            <end position="1729"/>
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            <begin position="1770"/>
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            <begin position="1947"/>
            <end position="2020"/>
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            <begin position="1426"/>
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            <end position="1382"/>
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            <dbReference type="ARBA" id="ARBA00004479"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00010504"/>
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            <dbReference type="ARBA" id="ARBA00013064"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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            <dbReference type="ARBA" id="ARBA00051722"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000259" key="18">
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            <dbReference type="PROSITE" id="PS50055"/>
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            <dbReference type="PROSITE" id="PS50835"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
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            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022092232.1"/>
        </source>
    </evidence>
    <sequence length="2037" mass="227491" checksum="2D22D6D5BB981B82" modified="2022-01-19" version="1">MLLRQSKYSSTSMLVCALIAYFLTSKFCVAVRPPVITRELQSESGIEGGVIAFVCEASGDPEPSFRWEKGSRNAQNSRSDIFPMPSGSVLRIEPLRDGRDDAEFHCIASNVAGSVRSTARLQVYASSSIPAGFPVITREPVLDVVEKGYPILLHCEAEGNPDPEIIWFKEYTPVDLSTERVKLTSSGLSISVSDFSDHGKYQCAARNSAGTRFSKAVPLYVRVRRVAPRFTIFPESQEVVPGGNVNLTCAANGSPMPVIKWMKGDEDLSSSDDDLPLGKSVLPLKNVQETAEYTCYAMSDLGEIQHSVTVTVRTRPDPPPVPTLSQHTANTVTVEWVAGTDEPIKAYVLKYALRSSPGAAIEIADITDTTYTILDLLPFTEYEVRVAAVNTIGRGDFSRPLTVTTAQLAPSTPPREVRASPLSASTILVQWEAPEVPNGIVRGYNIYYSNTPSQNLSFWYKHSVEDGTQRLTTISDLNPDQTYSIRASAFTAIGEGPASTAVQVITKQGVPSQPEMFAGEAISATQIRLTWRQRETEAQILYYELYYNDSKTGSDEHRSIPKAETYILEDLKPNTVYNIRLAAKSRAGQGASTPIVSVRTEQAVPGAPPQDVKASTLSSTSLRIEWEPPPQDRQNGDITGYKVSYVKIPRSGEVVEAQDEMLLAVGPNDRSCDLVNLDKWTVYQITVLASTKMGDGPASRPINAETDEDVPDGPPRKVVAEALNSTTIAVRWSPPALDRQHGEIRGYQVHYQVVSADEEPLGPPQVEWVALPDIRDIVLTNLSPKTYYSIEIAAYTIKGDGERSRPKLAQTPGQVPGQPPNFVVERLENGDYYAHWESPEDTHGVLLMYKLSYHTSTTKPLYLEIRPPSSDFSPIRLNKGKRYFFTLAAKNSEGYGLPAEFDLVTPEGKPTGAPQNFTGKALTSTSVQLSWSRPSDEESNGDITLYSILYYLEEDPGQEFISDTVDTIVTLTNLKPNTQYVFKVRAHTQVGSGPYGTTVILITPPLPPREAPRNIRVSPMSTTAILIEWKPPVDIENDRSGLTYIVYCTSESVDVDLSYWKRVVVGDFHQAEIGDLEPNTDYAVVVQLQTPEGNSPSSRIVYATTLGEESAAPERFQAELKDGNDVKLVWDAPSSSDGPIRVYRIVYATSPQAKEEHPEYTHEGLPIDVPNRERIFVISGLKPNMEYQFNITAVTKSSSSPPATVLVHTRRAAPAHVPILEVNKTLITASTLTITIPPLDSRGGPIHYVLIVVVPLDGPSLPKSLPSEYSMEDLLSATNSYNQRDKSVRRRRTTTKLLPYITAKLLAHELSEPFTIGDEQFINGFHNRPLEANRYYTFFMRAGVLSEEEELLVTSSDYIHPVQAKKQSVTVSGETLPNSNNPPEKDKETSGSPLAAIIGAVVGVLVLVVIIVIVVLLKFKRRSDPSVRRPKRKEVKTSNPSDPVEMRRMNYQTPAMMSHPPIPVMELSDHIEHLKSNENLLFSQEYESIEPGQQFTWDHSNLEVNKPKNRYANVIAYDHSRVILSRVDGLPGSDYINANYCDGYRKQNAYIATQGPLPETLGDFWRMVWEQRTCTLVMMTKLEERNRVKCDQYWPSKGQETYGDIQVTLHDMTDLATYSVRNFSLINIKKPADKREVRQFQFTGWPDHGVPEHATQVLAFVNRIKACNPPDAGPIVVHCSAGVGRTGAFIVIDSMLERIKHEKTVDIYGHVTCLRAQRNYMVQTEEQYVFIHEALLEAVQSGNTEVPARNLYSHIQKLTQPEPGETITGMESEFKRLANQKALPSKFVSANLPANKFKNRLVNILPYESTRVCLQPIRGVEGSDYINASHIDGYKQKSSYIATQGPLAETTEDFWRMLWEQNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMSEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPDQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRFESVVDMYQTVKILRTQRPAMVQTEDQYQFCYRAAYEYLGSFDHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YL53</accession>
    <name>A0A8B7YL53_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pre-mRNA-splicing factor SYF1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110981073</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093988.1">
        <property type="nucleotide sequence ID" value="XM_022238296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YL53"/>
    <dbReference type="GeneID" id="110981073"/>
    <dbReference type="KEGG" id="aplc:110981073"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000023">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000220">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000411">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000006">
        <property type="entry name" value="Pre-mRNA-splicing factor SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001071">
        <property type="entry name" value="pre-mRNA-splicing factor SYF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="9">
        <location>
            <begin position="176"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="382"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="803"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="803"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="813"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022093988.1"/>
        </source>
    </evidence>
    <sequence length="847" mass="98889" checksum="8BBA4CEF714F4646" modified="2022-01-19" version="1">MPILDQPSEVIFEEDDLPYEEEILRNPYAVKCWLRYIEHKSAGSHSALNLIYERALKELPGSYKLWYNYLKIRRKHVKGRCIIDPGYEDVNNVFERALVFMHKMPRIWLDYCQFLLDQRKIPRVRRTFDRALRALPISQHHRIWPLYLKFVKLYPLHETAVRVYRRYLKLFPENAEEYIEYLVSIDRLDEAAVRMADLVNNAAFVSKVGKSNHQLWHDLCNLICKNPTKVTSLKVDPIIRGGIKRFTDERGKLWCSLADYYIRSGHFEKARDIYEESIQTVTTVRDFTQVFDAYAQFEESMISAKMDTTAEMGHNEEDDTDLELRLERYEDLMDRRPLLLNSVLLRQNPHNVHEWHKRVNLFEGKPKDIINTYTEAVQTVDPNKATGKLHTLWVEFAKYYERHGQLPEARLIFEKGTKVLYVKVDDLGSVWCEWAEMELRHENSDAALILLRRATATPKNKAAYYDKSEPVQNRLYKNLKVWSMYADLEESFGTFKSTKAVYDRMIDLRIATPQIIINYGMFLEEHSYFEEAFKAYEKGISLFKWPNVYDIWNTYLTKFIQRYGGKKLERARDLFEQCLDGCPKKFAKAIFLLYAKMEENYGLARHAMAVYERGTEGVLPEEQNEMFNIYIKRAAEVYGVTHTRSIYEKAIEVLPDDQARDMCLRFADLERKLGEIDRARAIYAHCSQICDPRTTATFWQTWKEFEIKHGNEDTVREMLRIKRSVQATYNTQVNFMSAQMLAASKNPAGTVSDLGSGGLDDMKLLEQRAQAMAAEAEADKPKTKKDILFVRGSAKASDAELAEAARMANPEEINIDDEDEDSGEEVDEVQVETQAVPTEVFGNIQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLV6</accession>
    <name>A0A8B7YLV6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monocarboxylate transporter 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094249.1">
        <property type="nucleotide sequence ID" value="XM_022238557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLV6"/>
    <dbReference type="GeneID" id="110981195"/>
    <dbReference type="KEGG" id="aplc:110981195"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094249.1"/>
        </source>
    </evidence>
    <sequence length="316" mass="33983" checksum="F9236EB83DA05E79" modified="2022-01-19" version="1">MLIASAVTANLCVCCALIRPRKVHKAAKLMSDSTESDSPNEDGVAIDNNNTSTGDEVKIGTRETPDIVSDDLPTSGKVLQYDFSLTVEDKSSTSSDSSKCFFVKVLLRRISTELGLHTFAKSYRALLLCIVFLHNQAPYITFVTFLIPRVQAVDVTPSSATFLLTFVGIGVLLGRLSHGMLISWKKVPVEGVLGVMMALCGVSLIIMGVTDVYVLLAVSSFLQGFTTGATLSITLFLMRHFVGLANFAVSCGWITFVGGTGLFVAPIISGLVLDLTASYPAVFYIFSGISFLGALQCLLFPLLKRMEPGINSDNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YME3</accession>
    <name>A0A8B7YME3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110981282</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094433.1">
        <property type="nucleotide sequence ID" value="XM_022238741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YME3"/>
    <dbReference type="GeneID" id="110981282"/>
    <dbReference type="KEGG" id="aplc:110981282"/>
    <dbReference type="CTD" id="9948"/>
    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030834">
        <property type="term" value="P:regulation of actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="523"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022094433.1"/>
        </source>
    </evidence>
    <sequence length="599" mass="66195" checksum="9CC3229DF5472F3E" modified="2022-01-19" version="1">MPLAYERKSVFASLPRTERARAFNLGGDPKGKNFLCTHDVNVFIRDIENPAICDIYCEHSAQTSVAKYAPSGFYIASGDVTGKLRIWDTTQKEHILKYEYQPISGKINDIAWSPDSKRIAVCGEGHEKFASVFLWDTGSTVGKIDASTKHCNAVDYRPTRPFRIVLASEDGATTFYEGPPFKYSKDLREHSKFVNTTRFSPDGNFFATGSSDQKVFMYTGKEGDLVVELKDGARAHVGGVYSVCFSPDSTRLLSASADKTVKMWDVETHQVITTFKLGDTIQDQQLSILWQGDYILSASLSGYINYLDKNNPDKPWRIVKGHNKNISTFALSSDASCIYSADIDCNVMCWNAETSECEATTGKSHTNMLMDMSTNGDTLVTVGMDDKIRFIDTIKKEFTDEVIGLDSQPQCVTSKGDLIVAGTLQDLCLFKAHNKVDSDAIRYEAKSAHLSPEGSYLAIGGSDSKIHIYDVAEEKLKEVDQLTTNEPVCALQFSPDGLHLAASSGKKVLLFKVQEFQPVENFWSGHSARINSLSWSPDSKRFASVGVDGSVGVWALDTLRGSNMILGAHPKTIITKVAWRDNTTIVSAGHDKCIKQWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN83</accession>
    <name>A0A8B7YN83_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Transcription factor Sp3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110981049</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093910.1">
        <property type="nucleotide sequence ID" value="XM_022238218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN83"/>
    <dbReference type="GeneID" id="110981049"/>
    <dbReference type="KEGG" id="aplc:110981049"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000061">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF165">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="633"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="663"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="693"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022093910.1"/>
        </source>
    </evidence>
    <sequence length="762" mass="82113" checksum="B3BE9E4B47901CA7" modified="2022-01-19" version="1">MTTVSVTRAKSEYIQPSTTTQGDNSGQQQPSPLALLAATCSKIGSPPEEAVNTATTTAIRFVGQNQSFQPAETQICVGANGVIAIPAAQQQTQFQTISAFPVQIGAPPIVQPQQQQVIETNKQVTTSNTANVLNWNPQQQIVQPAQILTAAAANSNTSNAAAGTGNVQYNIIPQIQLDADGNIIANQIASAINQSPAIIRSPAPNIASLALQNGQLIQTQASPIVQNIGTAPRVASQPITFQLAPMVNTAGNVTDQQQQQVYSIVAASPIQQDFTNTVQLQPQQFQAQAQQIVTTDQTLQQQNQQPQQPQQISVAQVVPQQQQQQVHQQQQVVIPQQSTPIPVSINMAQPVQLQQQPQQSTVAIQQQSQQITNIQASSAQPQQQQQQSFTVQPVQQTYTIQQGTGLPIINTSQQTFTIPAQAATGQQAIQNIILQPQNNVQTIQLQGQQQMATILPGQILTALRSPNNTLNIQGVQIQGLSISGAVSQPQQILTTTAGTGNVGSVAATQVVTALPSINLSTGGNMVPMGVQIQQMPTTTAASSNARAASVTASQQANAIQDKKWQGQTQVIAQVQPSATLSMDNSFGGSDEEDNQGQSTQPTQKRLRRVACTCPNCKDSEGRNLNAEGRKKQHICHISGCGKVYGKTSHLRAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHRRTHTGEKRFPCPYCSKRFMRSDHLSKHVKTHNNKKGKDGDFEEGSVALDSSEVVSTPDNETLTNAVVLQMGDRTLDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNH2</accession>
    <name>A0A8B7YNH2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110981519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022094823.1">
        <property type="nucleotide sequence ID" value="XM_022239131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNH2"/>
    <dbReference type="GeneID" id="110981519"/>
    <dbReference type="KEGG" id="aplc:110981519"/>
    <dbReference type="CTD" id="6647"/>
    <dbReference type="OMA" id="AQRGFHI"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022094823.1"/>
        </source>
    </evidence>
    <sequence length="155" mass="15919" checksum="E9649210564EEAD5" modified="2022-01-19" version="1">MSAKSVKAKCMLHGETVKGQLTFEQEEGGPVKVTGDVTGLAPGKHGFHVHEFGDYTGGCTSTGGHFNPFKKNHGAPTDEERHIGDLGNVEAGSDGTVSVNITDKMISLIGPNSIIGRAVVVHADVDDLGKGGHELSLTTGNAGGRLSCGVIGISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNM5</accession>
    <name>A0A8B7YNM5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NF-kappa-B inhibitor epsilon-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110980555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093056.1">
        <property type="nucleotide sequence ID" value="XM_022237364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNM5"/>
    <dbReference type="GeneID" id="110980555"/>
    <dbReference type="KEGG" id="aplc:110980555"/>
    <dbReference type="OMA" id="HYAVEMG"/>
    <dbReference type="OrthoDB" id="10254947at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="289"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022093056.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="47093" checksum="044971A4872B5FA5" modified="2022-01-19" version="1">MSLPCDVETDCAMESPAEASSKMKNLPFDPKYRHLSGVGTSDRFDSHDSGIDSYRSVDSSFCFSTDSGRTESPLTSINEHESPLSQRLGNLHISSSLERCKDQESRTDTKLNTAVDDEAFVDSPATGEGISHLSGVEASTVVPTDETDRSGHGRYLTDDAYDQDQEGDTPLHLAIIHQKEDIAVNFIRLTLDPDLLNIRNDLAQTPLHLSVLTRQPVICRALILAGAQVDSIDRNGDTPLHIACKLSDDGCIRALTERISPLELQKGMVQHTAARVQQLPQDLELRNFEGFTCIHILGFLGDLEHLDYLVQLGANINAPDGKSGRTALHYAVEMGSLMLTHHLVNVLDADVDAMTYDLCTPLHLAVGRQLKAIVMLLVESKADTDVTNFEGDRPCDLSDDSQIMMYVKKHPHDDNEMIYSDIRIQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQ10</accession>
    <name>A0A8B7YQ10_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Organic cation transporter protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110981783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095364.1">
        <property type="nucleotide sequence ID" value="XM_022239672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQ10"/>
    <dbReference type="GeneID" id="110981783"/>
    <dbReference type="KEGG" id="aplc:110981783"/>
    <dbReference type="OMA" id="CEDNALR"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17317">
        <property type="entry name" value="MFS_SLC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="488"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="520"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="532"/>
            <end position="549"/>
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    </feature>
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        <location>
            <begin position="50"/>
            <end position="554"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095364.1"/>
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    </evidence>
    <sequence length="569" mass="63720" checksum="0E7DB38DA0CF55C9" modified="2022-01-19" version="1">MQFDKALKYLGDFGVYQRVVYFSLCLMAVPVAWHSTGNTFLSAKPAHQCRLYQGYVYNASEAYDTVRSCEIPKLKDGQWDSCNMYNTSATHDDNNGECNSTYLWQSIPCQMGWVYDDGIYRSTVVTEWDLVCEDNALRQLSKTLVLVGKLFGSLLFGQLADTFGRKKSFTLAILLMVACGTGSAFANSLILFLVLQFIIGVVSTATFVVAIVIANEMVGKSFRVTAGIVFEYFYTIGYLSMALIAWCLDGDWRKIELAISIPPIIFLAYYFIVPESPRWLISRGKMAEAEKIVRKAAKVNKVDLPNSVFEDKKDPEQKRLPCLSQLQENRHSEETKTFIDLMRYPNLRRKAFIVYFVWLSNNMVYFGLTYFTEDLGSDPYLSFFLAGLVEIPAYILCQLLLGRIGRKWLICIFMTVGGVSLLSTLAVPKGSSSYLYPLPHNSVTQNRFKRVVANNKENNNSNLGTLTLAIAMIGKLCISGSYAIVYLYAIEIFPTPVRNAGVGGGAMLSRIGSISSPYILLLADYTFPEFPFLIFGSFTLVSGILMLVLPDTMGVKLPETMQEGEDFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YT04</accession>
    <name>A0A8B7YT04_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">RING finger and SPRY domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110981310</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094485.1">
        <property type="nucleotide sequence ID" value="XM_022238793.1"/>
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        <property type="nucleotide sequence ID" value="XM_022238794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YT04"/>
    <dbReference type="GeneID" id="110981310"/>
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    <dbReference type="OMA" id="IAFDGCR"/>
    <dbReference type="OrthoDB" id="10017393at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16566">
        <property type="entry name" value="RING-HC_RSPRY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12883">
        <property type="entry name" value="SPRY_RING"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY"/>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR045129">
        <property type="entry name" value="RNF123/RKP/RSPRY1"/>
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        <property type="entry name" value="SPRY_RSPRY1"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="RING FINGER AND SPRY DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
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        <property type="entry name" value="RING FINGER AND SRY DOMAIN-CONTAINING"/>
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    </dbReference>
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        <property type="entry name" value="zf-C3HC4_3"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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        <property type="entry name" value="B302_SPRY"/>
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    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="333"/>
            <end position="516"/>
        </location>
    </feature>
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            <begin position="560"/>
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            <begin position="45"/>
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        </location>
    </feature>
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            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000694845"/>
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        <source>
            <dbReference type="RefSeq" id="XP_022094485.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022094486.1"/>
        </source>
    </evidence>
    <sequence length="611" mass="68974" checksum="6D1B24602A94CCD7" modified="2022-01-19" version="1">MIVTVWASYLLLQDPPPLFVYAARAFNSGLVCLARGIYHMGSSCFSKDRSRQPPCRHHQNHHGNHRQRHHHQQQHGQHGQPHPPPRGHHVTVMHQSAQQSLERQLRNVRHPNLFLTRLSSSDNDDDDDDNTNTDILVLDTLSIIRRLVDNDPEPPSSMLRLHDIAESESGWLRVVLSMIRVIPMEDGLGPAVITLLIDECPLPTVETIHRLYGALGIPKGLPQEALACAAKHRNIATVLGCLAEKLAGPKSITMLTGDVLQYLLSSLNLKFSPQVVLFSLIALEKFSQTSENKITISNSGIREHLLPLEKYANSEDLMLRQVGFCAQWCLDNLFLVEGRPYTHELVSLKDCHAMLNDRDVSEYLKITPTGLEARSDASSFESVRCTFCVDAGVWYYEVRIITDGVMQIGWATKNSKFLNQEGYGIGDDEFSFSYDGCRQLLWYKAKSRPHRHPMWKAGDIVGFLLDLERQEMLISLNGNFLPPERDVFTSAQSGFFAAASFMSFQQCEFNFGMKAFFYPPQVPFKTFNEYATLAPDDKVILPKHKKMALLRHMSVSENACNLCFDREANVILKPCNHSGVCMECAIQLEQCHLCRGSISVRAFLQDGELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YT67</accession>
    <name>A0A8B7YT67_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">G-protein coupled receptor GRL101-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110982060</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095897.1">
        <property type="nucleotide sequence ID" value="XM_022240205.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="6022531at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000343">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="159"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022095897.1"/>
        </source>
    </evidence>
    <sequence length="480" mass="53234" checksum="BF5460912422030E" modified="2022-01-19" version="1">MTNLIIDSIESNAFSDFASMKLLHIENVTINSIKPNAFSELYSLKYLLMQNVTVNFIPSGSFSPLWNLQGLLLLKISGTRSWATIEKGAFEGLITSKMNWIVTDDHRLCCTFSNLQNYSVRDDCLTTNLKPDLNLCDSLMPNNSLRVALWAQGISALIGNLCVIVWRLVQKGDREGKTTLSFMVGNLAAADFLMGVYMLIVAVADLRFGENYFLEAPEWRSSTLCKVAGVLAVLSSEASVFFITLISVDCFLGIVFPFRSFSLGKRSTKVIVFVLWCLALCVSVIPTVSVGPDSDAYGLSDVCMGLPLSIKSSRVVAEPPTFNDSDPESLTSYIPEKVLKAKAWKPSWILSIVLFLGVNLISYLFVLCCYVAIFISFKRTARTVRTEAERDREIKMAVKMFLIVATDFCCWMPIIIMGILSQSGAVVLSSNMYAWTVVLILPINSSLNPYLYTFFTVCCATKPKGKAIQSKAKSRKNKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUG0</accession>
    <name>A0A8B7YUG0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Snaclec EMS16 subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982315</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096342.1">
        <property type="nucleotide sequence ID" value="XM_022240650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUG0"/>
    <dbReference type="GeneID" id="110982315"/>
    <dbReference type="KEGG" id="aplc:110982315"/>
    <dbReference type="OMA" id="NCTARFC"/>
    <dbReference type="OrthoDB" id="6116550at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034771295" evidence="2">
        <location>
            <begin position="23"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="107"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022096342.1"/>
        </source>
    </evidence>
    <sequence length="232" mass="25287" checksum="B3AB93ACDA0B8648" modified="2022-01-19" version="1">MRIEEALITVILFLNAVRSSSASVCYAGQIFDASLNSARWVLPVTEPCRCTAVRPGGVLTTAPLLSVAPVDRGGGLLFSEVAEEFLTLFNCKAASCATLPGPGHWKTFDHCYLIVKQRLSYEEAESHCQELSQPGRSAHLASILSAAENAFLLQYNAAALPQSNFAVWIGYDRLSLDKYQWVDGSNGSGFTDWSPGEPTGGVEKCAVLWYGVHWNDWGCYNIAPFVCKMPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVR3</accession>
    <name>A0A8B7YVR3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110982580</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022096782.1">
        <property type="nucleotide sequence ID" value="XM_022241090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVR3"/>
    <dbReference type="GeneID" id="110982580"/>
    <dbReference type="KEGG" id="aplc:110982580"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022096782.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="33950" checksum="42A1C8DFF7D0541F" modified="2022-01-19" version="1">MAFQFNFDIGLQEQDNCDDDHVVGSSSGPSKDDSSKTKDILRPAKELYAPPTLTTTESCAVETLKIGNLELHFLNPEAVEFDRLLGSIEYGSDISKAAESHSDLIPNVYEGGLKVWECSIDLVHYLHEAELPLENKDILELGCGAGLPGIYALKRAAAAVHFQDYNEEVIEHMTIPNVALNQSDKAPTSQDLRFFSGDWSLVQEKIVSAHPDAKYDVILTSETIYSLESHDKLYKILRALLRRDGVVRLSRYIAAKTHYFGVGGGTRSFQDVVRQREEFSIQVCKTFTDGVKREILKMAFLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVU9</accession>
    <name>A0A8B7YVU9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arrestin domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097439.1">
        <property type="nucleotide sequence ID" value="XM_022241747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVU9"/>
    <dbReference type="GeneID" id="110982938"/>
    <dbReference type="KEGG" id="aplc:110982938"/>
    <dbReference type="OMA" id="HTHYHAT"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF176">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="174"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022097439.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="55858" checksum="95572BDB6F40EE5E" modified="2022-01-19" version="1">MGKLTVFEVVFDGDNVDVFSSGEVVNGYIRVVLTAPKDDVTAIKLKFKGKAHTHWTEGSEDEEESYSASETYFKEKIVCWGKDDKTRRCLEAGEHRFPFSFKIPDIPLPFPFESSLGWIRYKVKCKIDRPSKFDHHTERLFTVTGQPIDLRAMPNAMHPVRREDTKSVCCLCCETGPIITKASTDKAGYVPGETMYVSGTVENNSNRRILHLTVRLKQWVRYFSSGGHSTRREYNVINERAPGCEEGEVARMDWKPHVIPSIPPTGPQGCRIMRIEYVVHFEGDVENTPFDANVYLPITIGTVPVYRPPYQDPSGVIVQQPTSSGPPPPSYEIALEGLQEVPSKSGYDYTFGKLMYAPQYPTYNLPAQPPAWDPMHPPPVQDPTYPPGGYPPPSDPTYPPAFGAGYPPPGVPEGYPPPSAPQTYPPPAGGTGYPPPEGDAGYPPPAGTQGYPPPADGEGYPPPAGAGDEGQPPPVGSEDHTAAAGGGGEGSTDEKPPAEGTEVIELEKIEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWC2</accession>
    <name>A0A8B7YWC2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Thromboxane-A synthase</fullName>
            <ecNumber evidence="7">4.2.1.152</ecNumber>
            <ecNumber evidence="29">5.3.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">Cytochrome P450 5A1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">LOC110983046</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="32">Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:48856"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:57409"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:48857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:55556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59720"/>
            <dbReference type="ChEBI" id="CHEBI:131859"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:55557"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde</text>
            <dbReference type="Rhea" id="RHEA:48644"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:90694"/>
            <dbReference type="ChEBI" id="CHEBI:566274"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>prostaglandin H2 = thromboxane A2</text>
            <dbReference type="Rhea" id="RHEA:17137"/>
            <dbReference type="ChEBI" id="CHEBI:57405"/>
            <dbReference type="ChEBI" id="CHEBI:57445"/>
            <dbReference type="EC" id="5.3.99.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:17138"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 33">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 34">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="7"/>
    <dbReference type="EC" id="5.3.99.5" evidence="29"/>
    <dbReference type="RefSeq" id="XP_022097619.1">
        <property type="nucleotide sequence ID" value="XM_022241927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWC2"/>
    <dbReference type="GeneID" id="110983046"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004796">
        <property type="term" value="F:thromboxane-A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001516">
        <property type="term" value="P:prostaglandin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000182">
        <property type="entry name" value="Cytochrome P450 3A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="22" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 33 34" id="KW-0349">Heme</keyword>
    <keyword evidence="18 33 34" id="KW-0408">Iron</keyword>
    <keyword evidence="23" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="24" id="KW-0456">Lyase</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 33 34" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="17 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0643">Prostaglandin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0644">Prostaglandin metabolism</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="33">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00036380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00036475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00038872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00040834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00042726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00054825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="RefSeq" id="XP_022097619.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="42225" checksum="D2F9FC73C9DF34DC" modified="2022-01-19" version="1">MSSMINECCDTLVANIKRAEQDGQPIECKRLYGGFTMDSIAWCGFGLKIDSQKNKNDEFVVNARRVFSFERRPLMLLVSFLPFLNPIFEYFDVASMPAKVAQFFSSVTDQTRKLREEEALSNDRKKQIDMLQLLLNAHNETVEGDEEEAGPQLQTLKGSKRPLTNDEVTAQTIIFFLAGYETTNTLLGFASYLLAINQDCQEKLYSEILDVASSRDLVSYDTVGKMTYLDMVINESLRFYPPIAGFFRTCNKTFSYKGITFEKGTQVLINIYAIHHDEEYWPEPDKFDPERFSPERKASIPPMAFIPFGYGPRNCIGMRLALLEAKMALVRTLQQYRLDVCPETQIPLKLDAGPFTLPKEGIKLRPVARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWH5</accession>
    <name>A0A8B7YWH5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7">Ficolin-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">LOC110982599</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096835.1">
        <property type="nucleotide sequence ID" value="XM_022241143.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096845.1">
        <property type="nucleotide sequence ID" value="XM_022241153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWH5"/>
    <dbReference type="GeneID" id="110982599"/>
    <dbReference type="KEGG" id="aplc:110982599"/>
    <dbReference type="OMA" id="CVRECAM"/>
    <dbReference type="OrthoDB" id="6145874at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665620" evidence="2">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="107"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022096835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022096845.1"/>
        </source>
    </evidence>
    <sequence length="323" mass="36979" checksum="18CA3919DB60D3ED" modified="2022-01-19" version="1">MGRGNLLILAIFNIAGVSCVDHCGKFGLSYFAAENRALINKIIVVKTARSMVICVRECAMLPQCSSVNFHTDSRRCELGTGTRIQNPESFDEIHEVVYIDTIPDTPLHSVRHLSSCEGLLNSGFNVSGEYKIYPNGFWNGLLVYCDMETDGGGWIVMQRRQDGSVDFYRNWVTYRAGFGNLSGEFWLGNDILLNLTKYTGWWKLRVELEDWEKNTAWAEFGEFGLQGNLYRVRIGRYDTRSTLPDSLTWHNGRAFSTYDNDNDTPDYSCAQRFGASWWFGYCTTACLNGRYYHQARAPFRAGIHWESWKGKYYSMKGSTMKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXP7</accession>
    <name>A0A8B7YXP7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lipopolysaccharide-binding protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110983282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098108.1">
        <property type="nucleotide sequence ID" value="XM_022242416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXP7"/>
    <dbReference type="GeneID" id="110983282"/>
    <dbReference type="KEGG" id="aplc:110983282"/>
    <dbReference type="OMA" id="GKMWIAD"/>
    <dbReference type="OrthoDB" id="10255543at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.20.10:FF:000001">
        <property type="entry name" value="Phospholipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.15.10.10:FF:000001">
        <property type="entry name" value="phospholipid transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030675">
        <property type="entry name" value="BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="BACTERICIDAL PERMEABILITY-INCREASING BPI PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504:SF131">
        <property type="entry name" value="BPI2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002417">
        <property type="entry name" value="Lipid_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034382026" evidence="7">
        <location>
            <begin position="25"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="9">
        <location>
            <begin position="276"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR002417-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022098108.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="53578" checksum="C024F3DB550BF5CF" modified="2022-01-19" version="1">MAFAVIRVLMVAVVFVITSALGFAEVKPGFKARISQSGLNYLRDAGLQILREEIIKMDIPDLSGDAHVPVVGSISYTISDMHITSFSISSAVLTTSAGVGVVLQANGISLSLHGNWRYRNHGWIRISDSGSFDASLSGAHLALTLRIGIDQAGRPTVSSASSDCSFNSGSVHVKLHGGASWLYNLFSGSINKAIENSLNKQTCSVVIREVNTDLARQFSTLKTEAAIDRYAVIDYSFVSRPEFSGHIDTAHKGEVFPRGKPRTEAPFNVPTIPADPDVSHHAFLWITDYLFETAGYVYYKAGRFAYNVTQDKLPKGPFSFNTSSEVMKRTLPEVCKKYPNMLLQVNAKATAPPVVRISEANFNVLLKVDLDFFVILPSKSLAYLFTLNATVNGSTLLSCNGTNLLWSSNSLDVDISLKKSAIGKIEVKPLSEAVHFLTNFFLLPWINKKGETGFPLPTNPNIKFQAPVIKQGKGFIKLGVNVHFTPSVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXV2</accession>
    <name>A0A8B7YXV2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein KIAA1109-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110983309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098163.1">
        <property type="nucleotide sequence ID" value="XM_022242471.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983309"/>
    <dbReference type="KEGG" id="aplc:110983309"/>
    <dbReference type="OMA" id="MRHELRH"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033616">
        <property type="entry name" value="BLTP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056742">
        <property type="entry name" value="BLTP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056741">
        <property type="entry name" value="BLTP1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047104">
        <property type="entry name" value="BLTP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640:SF1">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31640">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN KIAA1109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25040">
        <property type="entry name" value="BLTP1_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25039">
        <property type="entry name" value="BLTP1_M"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20413">
        <property type="entry name" value="BLTP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01220">
        <property type="entry name" value="FSA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Bridge-like lipid transfer protein family member 1 C-terminal" evidence="3">
        <location>
            <begin position="4202"/>
            <end position="4808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1149"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1789"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2140"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2293"/>
            <end position="2319"/>
        </location>
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            <begin position="2339"/>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3262"/>
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        <location>
            <begin position="3368"/>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
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        <location>
            <begin position="4416"/>
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            <begin position="4696"/>
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            <begin position="159"/>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        <location>
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        <location>
            <begin position="3422"/>
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            <begin position="3544"/>
            <end position="3559"/>
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        <location>
            <begin position="3563"/>
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        <location>
            <begin position="3724"/>
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        <location>
            <begin position="4009"/>
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        <location>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4100"/>
            <end position="4113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4147"/>
            <end position="4158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="4176"/>
            <end position="4187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4190"/>
            <end position="4212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4420"/>
            <end position="4442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4696"/>
            <end position="4713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4722"/>
            <end position="4733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022098163.1"/>
        </source>
    </evidence>
    <sequence length="4813" mass="527880" checksum="D2F3DDDBE108309F" modified="2022-01-19" version="1">[encoded data, 4813 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZT7</accession>
    <name>A0A8B7YZT7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110983697</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Golgi apparatus membrane</location>
            <topology evidence="1 11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022098863.1">
        <property type="nucleotide sequence ID" value="XM_022243171.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098872.1">
        <property type="nucleotide sequence ID" value="XM_022243180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZT7"/>
    <dbReference type="GeneID" id="110983697"/>
    <dbReference type="KEGG" id="aplc:110983697"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022098872.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44265" checksum="963FE02AF453C8E6" modified="2022-01-19" version="1">MGGRKRRKQLRQRLACVIFIIAVGCCMYVISTRSERGSFESVEVEEWPTESGHHLHQQQSLFSDDIINPHPYHFTISNPTHCHDMNTSEDGQPYLLILVKAAPGDFYDRQQIRQTWGGTRIVGQQLTSTLFLLGLSRDEEVNERIREESILYEDIVQENFIDAYLNLTIKNIMGMKWVATFCPNASYVASADADVMLNTFNWVRRLLVKPRRRYAEGSLRRNTMPVRRPDKHNAKWLTSRELYPEATYAPFFPGSCFVLSRDVAADIYNQSQHVRFLPWDDVFVGLVMKRIGIKPRHAKGYEQYVRLSSSKAITRALRRGIAVLIRHQVDSVDEHLLALWKSAVTLSQRQEEPHSASPPQTAVFAVAIILFFFLFYSVGVALMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZT8</accession>
    <name>A0A8B7YZT8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyglutamine-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyglutamine tract-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC110983700</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. Interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. Forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. Interacts (via C-terminus) with TXNL4A and CD2BP2. Interacts (via WW domain) with ATN1 and SF3B1, and may interact with additional splice factors. Interacts (via WW domain) with WBP11; Leading to reduce interaction between PQBP1 and TXNL4A. Interacts with CAPRIN1. Interacts with DDX1. Interacts with SFPQ. Interacts with KHSRP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022098864.1">
        <property type="nucleotide sequence ID" value="XM_022243172.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098865.1">
        <property type="nucleotide sequence ID" value="XM_022243173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZT8"/>
    <dbReference type="GeneID" id="110983700"/>
    <dbReference type="KEGG" id="aplc:110983700"/>
    <dbReference type="CTD" id="10084"/>
    <dbReference type="OMA" id="YDKPDRD"/>
    <dbReference type="OrthoDB" id="42462at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF3">
        <property type="entry name" value="POLYGLUTAMINE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="14"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="108"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022098864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022098865.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26794" checksum="84019542A738FDC0" modified="2022-01-19" version="1">MPLPAALAARLRKRGILQDGTSPQDPHEEIIAQDYSTEDMPSQQKASAGEDAVVAPAAGESLPPGWFKVKDHVSGYHYYWDAEKDLVSWLPPSDPKAQVTLPAVQLNEAQDHKTKTQSQPLPPGTEVRSANEIRHERPMVGTIGPMRPGSEPRRQAERPSPYQKSHREDRESQRHRSKKDDELDPMDPSAYSDAPRGNWSAGLPKSNEAKTGVDTTANGPLFQMRPYPNPGAVLRANAGKNAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2K2</accession>
    <name>A0A8B7Z2K2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Heme transporter hrg1-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110984213</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099848.1">
        <property type="nucleotide sequence ID" value="XM_022244156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2K2"/>
    <dbReference type="GeneID" id="110984213"/>
    <dbReference type="KEGG" id="aplc:110984213"/>
    <dbReference type="OMA" id="HIACWGL"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="HRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31525">
        <property type="entry name" value="HEME TRANSPORTER HRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31525:SF1">
        <property type="entry name" value="HEME TRANSPORTER HRG1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF16954">
        <property type="entry name" value="HRG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02095">
        <property type="entry name" value="TRNSPORTRHRG"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="100"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="46"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006203"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022753"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
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    <sequence length="194" mass="21521" checksum="8187124C50FB867A" modified="2022-01-19" version="1">MSHLSSAPDVADTASSQEIKDDAGLPTPAFSSTSTSTQKQPTAMEPTPTAMRCRIGLAVTGISVGVLVFIVFLAMADFRNYHIACWGLASGIFAVFTLIVHIQHLKGNHDVWLNRLKLPIILGFFVQLGAVAAFITYIALAAVQKQPVTPLNGPHRGYYVAAVWVFMTWKWSFALFWYSKSYRRFYITKYVSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2X5</accession>
    <name>A0A8B7Z2X5_ACAPL</name>
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        <submittedName>
            <fullName evidence="14">Metabotropic glutamate receptor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110984270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022099974.1">
        <property type="nucleotide sequence ID" value="XM_022244282.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
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        <property type="entry name" value="GPCR_3_C"/>
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        <property type="entry name" value="mGluR"/>
    </dbReference>
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        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
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        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
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        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
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    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034629213" evidence="11">
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            <begin position="26"/>
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    </feature>
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        <location>
            <begin position="570"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022099974.1"/>
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    </evidence>
    <sequence length="869" mass="95158" checksum="500F46D1521B2522" modified="2022-01-19" version="1">MPCATTIMDRSSLAVLAVCLHLAHGAHLPPEVCSMYAKKGDVYIGGVFSLHGDAKGVDNRCKTRLPISALHVVEAMVFAVQAINDDDKVLPNVTLGFMIHDDCSRDEYAIWGSLALLMGAKGVTEGESCMIPGMTTDVEVRSVVGIVGTGKTSSSEVVASTSGLFERPLVSYGATGQKLLEENAFLYYFSTISSDQYKVTAILDLLDLFEWQYVALVYAADYDMLNMMGELQIAANRRRVCVHVQAMVSEAPTEKELHKMVKLLQNNTYAKVVVLLAQSAVTANAVFSAAMKADPPVNLTWVVGNSLANQDVLEEDLARGNLFVEYGTPELNEFEQYFRSMMGSKRANADNPWFDEFCGDLDRCLSFSAEGFSKAIPTLSATIDAVYALAFTLDEVIRRLNCTGTVANCLASQGANTLFTGMLHNVSFRGTRGDFKFTEYVRSVPGHFIIRNMQEIDGASKMVEIGSWNSLSPSHESGNETRLTVYKSLIQWNGHSGGETPRSVCRDDCAPGQVEEPLKKKCCLGCRECKADEIVKRSTCVQCREMEWPNDNQTECLALVPKTVTLGEPLVILLFLFACLGLVLCLLTASGMVRYRQHSLIKATSRELSCVNILGLVMGYLAVFPLLQSPKPLTCAAAQALYVLAFTLMYGSLLLKVNRIYRIFESSINSAKSPRFTGPRAQLMIAAVLVVIQALIMFITGVAVPNTWISIRKLFPTPLTINQPRTLENFCKLDYGFLVSMCYNAVLALACSLYAYKARNVPGNYNEAKFYAASVYTTLVLSLAALPVYFIAETALALAVSLSLVPIMDGYVTLLCIYLPKLYVVIFKKLGDGDNQGDANGGRFRPRKLPALVSTGNVTKVHPSQTSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4L3</accession>
    <name>A0A8B7Z4L3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110984161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110984161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099725.1">
        <property type="nucleotide sequence ID" value="XM_022244033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4L3"/>
    <dbReference type="GeneID" id="110984161"/>
    <dbReference type="KEGG" id="aplc:110984161"/>
    <dbReference type="OMA" id="YACANKI"/>
    <dbReference type="OrthoDB" id="10654874at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:collagen binding"/>
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    </dbReference>
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        <property type="term" value="F:extracellular matrix binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="KAZAL_FS"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Kazal_dom"/>
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        <property type="entry name" value="Kazal_dom_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
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            <begin position="22"/>
            <end position="249"/>
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            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="196"/>
            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="197"/>
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    </feature>
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        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022099725.1"/>
        </source>
    </evidence>
    <sequence length="249" mass="25867" checksum="053D2E4A488BCD63" modified="2022-01-19" version="1">MRTVTIFAVVLLVALVSVNECKPFGRHRQGNRHGDRDQDTDRPQCRRRCPRPTPATRVCASIGLRNLTFPSTCFVDKIACLKGRNITVIGEGRCPRLCPALQVGGGKGRHDQESESEEDNSLESDEMEDGTTSGLGPVTSPSTEQPPSAGTTMTNGPVTNPSVSSGPTNPPTNPPPGPFSSEPTPSSNPSASPTVNGPSTTCVTACPVATTPVCGTDGQTYPSACVLEAYACANGLDTLTVASEGACPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5M6</accession>
    <name>A0A8B7Z5M6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="9">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110984393</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022100262.1">
        <property type="nucleotide sequence ID" value="XM_022244570.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100263.1">
        <property type="nucleotide sequence ID" value="XM_022244571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5M6"/>
    <dbReference type="GeneID" id="110984393"/>
    <dbReference type="KEGG" id="aplc:110984393"/>
    <dbReference type="OMA" id="TIVGDHK"/>
    <dbReference type="OrthoDB" id="535945at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000216">
        <property type="entry name" value="Tyrosine-protein kinase SYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="23"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="11">
        <location>
            <begin position="177"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="417"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022100262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022100263.1"/>
        </source>
    </evidence>
    <sequence length="687" mass="78247" checksum="C650A6EF6590A55E" modified="2022-01-19" version="1">MMNGMSKRYAENTPPQDPITVRYYHGRITREEAEARLRCQGGVQGDFLLRDSLGKEGHYAISLCFDGNIYHYAIERQHDGGVAIKDGNRFPGPVELVQHHERKLDGLLCLLQRPCCLPEGQKPRAYGDLSHEEMENEIALVAQNQGLSKDTIQKAIASNRSQFDRLVKSILHQERPWFHGQLTRAEAEQRIITSGLQEGKFLARERNEPGSFALTLCYNNSVYHYKIDKDCTGQLSIKDGPKFDSLLQMVDHYTLKKDGLLCCLMVPCIDPQKRRHSAGPAASASQNYRRVQSNDEESMPARSPPAPPQPRRGNTQSAEETTLASFMPPPLKPHVPYHPSHPVHPPHMPRQRPMIEQIVNGKWEEPDHHDEPSPQRLSSQEPPVVDDKTYGVPNDREMIYGQVAKMRNTKLLDVKHLYRGEPIGKGNFGSVLKGTYNMHGTHIPVAIKTLKTENGIPNSKPEIVKEAEIMADLDHQHIVRMIGICEGFEMMLVLELAELGPLHKYLKRHTNMSIRNVLELMLQVAKGMRYLESQKFVHRDLAARNVLLVDETFAKISDFGMSKALGLDSQYYVAETAGRWPLKWYAPECIYRFKFSSKSDVWSYGVTLWEALSYGKKPYANMKGQELMAFIESGSRLAQPERCPPEVYTLMRQCWEDEARDRPSFGEIVDTMTSIIRRLRAGTLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z689</accession>
    <name>A0A8B7Z689_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Vasorin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110984872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101154.1">
        <property type="nucleotide sequence ID" value="XM_022245462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z689"/>
    <dbReference type="GeneID" id="110984872"/>
    <dbReference type="KEGG" id="aplc:110984872"/>
    <dbReference type="OMA" id="INMETSI"/>
    <dbReference type="OrthoDB" id="694479at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF96">
        <property type="entry name" value="LEUCINE RICH REPEAT CONTAINING 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034571397" evidence="4">
        <location>
            <begin position="23"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022101154.1"/>
        </source>
    </evidence>
    <sequence length="460" mass="51212" checksum="39CF5AE5139B849A" modified="2022-01-19" version="1">MAIFAVCRPFLLSLCFVFTSCAAPSFNQSSQLLQLCQICKCDRRNSAKLVNCSYAKLNDSDLASADLSDTHTLILSNTNLEHVPDLRASQLVTFDLSHNHISDLREIPDGAFRNLRRLRDLNMSHNRLSKISKEMLHGAKGLVNLDMSYNEISMTAADAFAGLTNLATLQLDHNQLEEVPTVFKNNNIDLRQSLQTINLRGNPIRELPEDPFGDLQYLHYLDLSRMKLEYVHPDAFKGLTTGLYELHLNSNKLQTLSVQTIQNLRYLTSLSLYDNPLACNCTLADLASYLEAQPDISIVDLDTTHCSVDGSPNILFISREISMFCTSFPMVEVIVGAVGLAVLITLVVIITYFYRKRHKSTGKHSLSDHANNSTLTVETSFQLTHVQTSAEDKTNTLEVCTRSEHFYSSIKSLQSPVYAYAQVPGGVSGPKTVEPVATYKNVSCPQAQQAANYYLVPSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7P2</accession>
    <name>A0A8B7Z7P2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIM56-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110985159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101673.1">
        <property type="nucleotide sequence ID" value="XM_022245981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985159"/>
    <dbReference type="KEGG" id="aplc:110985159"/>
    <dbReference type="OMA" id="ISAYCIT"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022101673.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="25806" checksum="28DDAD5E007180A6" modified="2022-01-19" version="1">MASALEKISQHLECGICQDRLKQPKVLNCLHSFCQECLQDYYKRRYKEAPEIPCPVCRRVTALPETRIQGLKTNFHLMGITEEISDCELCEEENEATHRCLDCXQNVCPNCRKTHLRCVATSNHTVATFEEIRQGKVTVKKSENHTKFRCQKHGGEVRRFYCETCQELICRDCTVVDHRIPNHHYVDSGEASIKYKQSLKDMLPDFDVDIKVLEQSLAASSEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7Y7</accession>
    <name>A0A8B7Z7Y7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calcyphosin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110985222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101774.1">
        <property type="nucleotide sequence ID" value="XM_022246082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7Y7"/>
    <dbReference type="GeneID" id="110985222"/>
    <dbReference type="KEGG" id="aplc:110985222"/>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051581">
        <property type="entry name" value="Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524">
        <property type="entry name" value="CALCYPHOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34524:SF6">
        <property type="entry name" value="CALCYPHOSINE LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022101774.1"/>
        </source>
    </evidence>
    <sequence length="150" mass="16795" checksum="FF4E4A0FD81ECF75" modified="2022-01-19" version="1">MKAGMRAIGLSADSVSDAELEEVFKTLDKDGSGSLNLNEFMNALTPSLSTKRKEILSAVFRKVEKTGDGAITANDLTRFYIAKHHPAVVAGRKTEEDIKTEFLNNFEVDKVTRDGKVTLEEFERYYAEISQGCDSDEKFATLVKNTWDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z847</accession>
    <name>A0A8B7Z847_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tectonin beta-propeller repeat-containing protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110985246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TECPR1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101838.1">
        <property type="nucleotide sequence ID" value="XM_022246146.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985246"/>
    <dbReference type="KEGG" id="aplc:110985246"/>
    <dbReference type="OMA" id="CPMQISR"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF1">
        <property type="entry name" value="TECTONIN BETA-PROPELLER REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06462">
        <property type="entry name" value="Hyd_WA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19193">
        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00694">
        <property type="entry name" value="DysFC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Peroxin/Ferlin" evidence="4">
        <location>
            <begin position="69"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="5">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="4">
        <location>
            <begin position="1056"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="5">
        <location>
            <begin position="1126"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="567"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022101838.1"/>
        </source>
    </evidence>
    <sequence length="1414" mass="158127" checksum="58267BBD1CE8EF78" modified="2022-01-19" version="1">MVSQNYLWAVDNCGHIHTLSTTFQLWQRRSHASDGHLVEFKKVTASKHCAWALGCDQELYVFMYPSDVPIRCLEYTYENQRWNPVHGFSQKGLFPTDRDGWSDEKGVRSLPKPLDIQLPSKHWVWEYEWHVDESIKGKRTGKGGWQYAVNFNARENFTAEKHWNSCVRRRKWIRYRKFKATGVWAVIPSLFPDALEEPFHDIAIGGGELPGQPEGYLSVWTITALGKVYCRTEVNLKCPEGIDWKAIKTPEDKGLVHISVGPTGVVWGVTWDGLGIVRTGVSRDHPLGIGWQYVAPPEEAGLGQVAVGFNAVWAISRDNKVWFRQGFEALKALVDTDACKGTSWVEMVGQMAAISVGPNDQVWALGFVDRQIFFRAGVTQEELCGRTWKLIDVHERHRSSSGGSYMYEINSLHGSMSSLSLGSDNSPSWTGKESPINMDGDELQRTARSVTMPALALGTRPLKMGSEMISRNALGKIVRTIAIQTNEVLAPVTADLDREEKSEMKVDLHPMLVRAKWTSGSQSKDEDIVISRHVTQSNLEINKIGELNKRNSRGKLMSISECRNADRIESNPLGTMRTASSDPSLSSSAEDSGFSSDPSKAYCAPQGNGVTLSQLHKDYEKRELTRQDSYSSDYSDTVIDFVGSLDELHSPERLDTETNKATQTEVITEDLPATESLTSQESHSQSIEDLNNTVRLMRRNAYRSRSETCPMPAPVITIDDVDPTNNSLSTNKTLRSISLEQNGIPSQDSLSSDVSNEDHLTVSGMDTYLDSSLADLTSSGEGGCLLWVSVSGAGCIIDPVSPPKWFDQAVVSNASLRHRLMDGSWRWKILALLKSRREQETSAFSNIPLAVERTSWVKVGRMQWYSEGKRRQWIDCTVELQKGVDGIGLEEPTFTCHHNQYGKIKQIQFLLSEITCVLEVNNFDRPAFAIYTAKRVLERRPVKLRVGNDKELQEWVSALSLACCESRGINGPPLPNAAWCITCRGDIFVYDTLPNMETAPSSLMFWRQIGGHMAVIEACPAGVVWGLGMDNTPWVHTGGYGGGIFKGVYSGIGSQTDHKHVCIYEIQRWNPLLGFTDRVYPDAGWTDEAGKMECSKEAVNPPTRHWQWITEWRVDFTVPGSTDNEGWQYAKEIKSRKGYHKDKRWNDYARRRRWIRKCQLVTTGPWREIPNLTLSDVSMQPDVDEDWDGPIALWAIGSNGDVLTRLGVTRHCPEGYSWLHVPTDQSFQSISVGGNYRVWAVAKDGSAFFRNGIHGQNPTGDAWFHIALPAIAPLIQVSCGATAVWAVDSQMNLWFRENITPTFPEGTRWIHVSNKVRKVSVGPQDQIWIIADEVNGAKGVICRREGINPKKPTGTSWDKGAGGGIMYLTVRSCAKERSLQVKMADIAQAMVQGQVENTPGIIQPYTSSMDNVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z864</accession>
    <name>A0A8B7Z864_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Trafficking kinesin-binding protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110985248</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the milton family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101845.1">
        <property type="nucleotide sequence ID" value="XM_022246153.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101854.1">
        <property type="nucleotide sequence ID" value="XM_022246162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z864"/>
    <dbReference type="GeneID" id="110985248"/>
    <dbReference type="KEGG" id="aplc:110985248"/>
    <dbReference type="OrthoDB" id="10067624at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048311">
        <property type="term" value="P:mitochondrion distribution"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HAP1_N"/>
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        <property type="entry name" value="Intracell_Traff-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022154">
        <property type="entry name" value="TRAK1/2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15751:SF12">
        <property type="entry name" value="TRAFFICKING KINESIN-BINDING PROTEIN MILT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Milton"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01423">
        <property type="entry name" value="Milton"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAP1 N-terminal" evidence="8">
        <location>
            <begin position="82"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking kinesin-binding protein C-terminal" evidence="7">
        <location>
            <begin position="453"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="771"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="971"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="1089"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="303"/>
            <end position="382"/>
        </location>
    </feature>
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        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
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            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
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            <begin position="832"/>
            <end position="841"/>
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        <location>
            <begin position="975"/>
            <end position="993"/>
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            <end position="1030"/>
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            <begin position="1050"/>
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            <begin position="1110"/>
            <end position="1121"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004173"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007007"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
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            <dbReference type="SMART" id="SM01424"/>
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            <dbReference type="RefSeq" id="XP_022101854.1"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z883</accession>
    <name>A0A8B7Z883_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc metalloproteinase/disintegrin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101873.1">
        <property type="nucleotide sequence ID" value="XM_022246181.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110985271"/>
    <dbReference type="KEGG" id="aplc:110985271"/>
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    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M12B" evidence="3">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
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            <end position="15"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
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    </feature>
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        <location>
            <position position="92"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101873.1"/>
        </source>
    </evidence>
    <sequence length="146" mass="16168" checksum="DCA79D3905AD19C8" modified="2022-01-19" version="1">MVILTPSQPGFTTSSDPEESLENAEGWLQNNRYPSSDKRHWDNAAVMSGWSFTEDTLGLANLGECDNEKAVSISSFLGFDVATDTAAHEIGHNLGMCHDSFQNNCPPSGYIMAAETTDVRVKPKWSSCSKRYYNHFIASKDCYNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8H8</accession>
    <name>A0A8B7Z8H8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor AP-4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984077</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022099576.1">
        <property type="nucleotide sequence ID" value="XM_022243884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8H8"/>
    <dbReference type="GeneID" id="110984077"/>
    <dbReference type="KEGG" id="aplc:110984077"/>
    <dbReference type="CTD" id="7023"/>
    <dbReference type="OrthoDB" id="10029128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11419">
        <property type="entry name" value="bHLHzip_TFAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="42"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="9">
        <location>
            <begin position="277"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022099576.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="40148" checksum="86342107D3E3594F" modified="2022-01-19" version="1">MAYYMRKMEKAYADRSDVLPNPIVTTVGRCSPNSQKEQEKRIRREIANSNERRRMQSINSGFQSLRTLLPNHDGEKLSKAAILQQTSDFIYRLEQEKTQLLNQVIHFKRIMRKYEREDPDSPSPKRRKRQDSMTDEGIGSPENFEDTNIDELKRELVDLRCQLDRERRYRMLLEEQNRSLESQLYPEKLKELAQQIKLQEQRAYEERKILEQAPPAPRPVIMQYQIPPPQTHIISPATTLTTSRQNLETIVQAIRHLEGEKTTPGNTPQQTPSHTPTPEDEARKVREDEETLSGDEDVYRKEHSERSVIVTDSETIRNVSNRVTVELLHPIDRLKTRPSIIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9R8</accession>
    <name>A0A8B7Z9R8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 150-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099991.1">
        <property type="nucleotide sequence ID" value="XM_022244299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9R8"/>
    <dbReference type="GeneID" id="110984282"/>
    <dbReference type="KEGG" id="aplc:110984282"/>
    <dbReference type="CTD" id="284992"/>
    <dbReference type="OMA" id="TCRYNPG"/>
    <dbReference type="OrthoDB" id="416454at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038807">
        <property type="entry name" value="CCDC150"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35352">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35352:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="297"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="506"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="596"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="967"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099991.1"/>
        </source>
    </evidence>
    <sequence length="1132" mass="128926" checksum="15CC15F6347EA960" modified="2022-01-19" version="1">MSRQPRPVMPPSRPAGKSPTAQALSLLQKKLNTAEAETANLVRQLADLGFPTDSNPQSKNKDSAEPVAPFLPSTADNEALRKHYEALVGRLCRTESQLQTLKLNLCALQAERDLGREGAALAAATALNEESLMRHREAHEDEVRKLNKELVRTRTEWKEVLEQRNEADEEARRLSIALEEATTAKSELAVAYEDLMSSKQKINKRNSELREELAREGSLRRSLEDSHGALLERVREMEELVESERQEVQILSSDCSELREEGARIQKERRSQASQQARLEETVRTLRGDLGAKEVQLAEIREENQVLLSTLNGIKRENVALRNEMQNSRAASHSTEAQVQQFEEERSALYSALTQALSASTSPQGLQQIAKISEPGSVALKVTDSLRRLEAERTRLQSLLSEEKKQKESAERISSELRDSLRIADERYQDATQQHQSHVQSLENAIDDLKQELAALQHRNQDALKAKEHLLQEVNLAVDGMSDETARLHQELAQSKLEVTSLGHDKQYLTEENRRLMERITALEQQQDAQEKVQSTIAELLESKNRLAYDKGRLQSRVDQLQKELEGLANARTDGLQLQKVNVAMQAQYTKTTSELSSVKVTMQRLESKLRQEQELSSRKEKDFTLAIQARDEAFQECERLKGQLQVMDDREKQKAASFQRSLADAKTDQSKIAATLEGVMASHTQLQTAVESLQVELGRKDSELSSLRTERQSRQKTMESLQREVQKLTEKLVTVETLEGTQLDGLRSDLDRALAEKSKLGKTVDELLQANGKLQATTERIQNQLEKRNHKYKLLQDTREREKSDLQDQLQASRDQLLALQQQLASRRDASLKNATQELDQLQRAHQQLTDRLREQTGTNAELRAKAAGLEETCNRQRDRIRSLKAQLESCSQLRKTNAEMTVKIKDISQQLSEMEAAKRDYTRKNSEQAKTIANFVQQVAGLQADLQALSKAQDSLSSSTRKKDRQAEKERNQLQHQARDLQEALARMQEEKRDAEEKLLEASNESMQITANLQEAHSWFKARHDALQQELTEARQRQTQLERNNAEQQQQLLQEASRQALSHLARQAEADHQKTKLQMTSMVKRLQAEKDHSTFTDNKLQKFMDISGQYIEELAMELDRHRSSQDDDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZA49</accession>
    <name>A0A8B7ZA49_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Neuropeptides capa receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110985659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102533.1">
        <property type="nucleotide sequence ID" value="XM_022246841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZA49"/>
    <dbReference type="GeneID" id="110985659"/>
    <dbReference type="KEGG" id="aplc:110985659"/>
    <dbReference type="OMA" id="WYFNFSN"/>
    <dbReference type="OrthoDB" id="6088609at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="24"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022102533.1"/>
        </source>
    </evidence>
    <sequence length="352" mass="39396" checksum="A32C8FF8898EB88C" modified="2022-01-19" version="1">MYSSGDTTVICVIMPLILTVGFFGNGAFLLVVARVEWMRQVSSNSYLACLAVVDITFVAVAVAGKLSRFLSSPVVTDESILGVPGCVLLYFVSDLCFYVSLFLITLLSMERYSAVCKPFSFRSSSDGRKRVVGRIVWCWVISASAACLLIPDRLEWDESCITWSPPEEFDQLPRITGSCTSVVAWYFNFSNCVQVVPFFATMFVNFSVYVLIARKLRQQARTRQRLSSEIALEQAQIRDQITRMLIINGTTYFVFLMPFEALALGLAIKRLTGTPSVLTEDQFSLTLNICRCLLYTNSAVNPFIYTLTSPAYRRAFVEGLCPSKCPRGSSQNLIGMSNIQTKARLDSERRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZA62</accession>
    <name>A0A8B7ZA62_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110985174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110985174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101705.1">
        <property type="nucleotide sequence ID" value="XM_022246013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZA62"/>
    <dbReference type="GeneID" id="110985174"/>
    <dbReference type="KEGG" id="aplc:110985174"/>
    <dbReference type="OrthoDB" id="10020332at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF25">
        <property type="entry name" value="PROTEIN LIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022101705.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="38814" checksum="DAA43B6678CF1DB8" modified="2022-01-19" version="1">MYDEHQEKVSKLLQGKQHSLEVAKDVTSTASDNDFLSLYPVISKDLKSLKSRNPPKVDVFLSYLSFTPGQWTDINLGELEEKGRKWEMCCEVGKTGDSPGNFQLAISVAVAPSGEVAVADCLDNQVVLCSSEGQPKAKIPLHSRPYRITAVHSHDNQLVVVDDTKYVKVFNKKNKLAFQFPTVPQSAVDKTRMNLRGVAVRKDGTILVGDVNRMVWTEHSPTDGALLRTIPVQTPPWFLAVDDHNDRVVVSGGGSQKVDIATNYGITLATIRPTIKGQQVQLCHGVCCNNSGFCIVVRNGPNTGHVHHYDLDGNFLIWWAQGLSNPYGITFTPYGKFLVADSYSVKMYHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAB9</accession>
    <name>A0A8B7ZAB9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THO complex subunit 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102619.1">
        <property type="nucleotide sequence ID" value="XM_022246927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAB9"/>
    <dbReference type="GeneID" id="110985710"/>
    <dbReference type="KEGG" id="aplc:110985710"/>
    <dbReference type="CTD" id="9984"/>
    <dbReference type="OMA" id="LQREEMW"/>
    <dbReference type="OrthoDB" id="10257415at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="571"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102619.1"/>
        </source>
    </evidence>
    <sequence length="648" mass="73718" checksum="385A90338FD7B2C0" modified="2022-01-19" version="1">MAAPSFDFVSARQTFCEGIEQAFLSPGTEKLKQQSSTVDGSEAEKKVALDQAFRDVMVNLVVKDSDCQHFTSLINLSIEAVHLGICSPATPFLLLTDVFESVPISVCDTVFRFVEERVDTWKSNVLYTSGKNFLLRMCNDLLRRLSKSQNTVFCGRIQLFLARFFPLDEKSGLNLMSQFHLENITSFNTEPLDGPLRSEDKDDTMEVEEGEMASSSSPIDYLLYRKFWALQDYFRNPTQCYIKDKWRLFQRNARAVLGAFSSLKLDDITASKTQDETPTGKQVFFAKYLTSEKLYDLQLNDVSFRRYVLLQFLILFQYLNQHVKFKGAQQVLTDDMSQFIKTTTETVYDLLKETSPGGEEFAKTIQHILSREEHWNTWKNEGCPSYIREKPDSAQAQPKPRARKRSLGEELRINAPNKKIDMGSPELTRLWNICPDNLEACRAENRIFIPSLEEYFEEAIEQADPGAMIEPEYKVVNNSNFAWCALRLLARRSPYFFQTITSSQPPVKSVPAYLELMVTKLAKDMPQPTVEELKTEAVVEENDDLLKGGEEGLEKSNILLVEEVEAVSARLGENWKTLASELNFTDEEIGSIQTENLEIREQANAMMGAWLGREGEQATRDELIGALLESGLNDIVESVLTDNGKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBC4</accession>
    <name>A0A8B7ZBC4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aspartate beta-hydroxylase domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110985420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102120.1">
        <property type="nucleotide sequence ID" value="XM_022246428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBC4"/>
    <dbReference type="GeneID" id="110985420"/>
    <dbReference type="KEGG" id="aplc:110985420"/>
    <dbReference type="CTD" id="57168"/>
    <dbReference type="OMA" id="HIPSKDC"/>
    <dbReference type="OrthoDB" id="438431at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051821">
        <property type="entry name" value="Asp/Asn_beta-hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332:SF5">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="4">
        <location>
            <begin position="163"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022102120.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38693" checksum="DAB36D7683EB5594" modified="2022-01-19" version="1">IIERASRPRPNVVTCPFTSSAAVSCDSKVIVQCYLSWRQKGIAHKQNTTKRRESANYDDFSKCASSNCVRCQNYERLTSNLLERFLKYISQIKCEEQEALVRLQLSVENDLNMLKSGSSRDKSQNMQGSTSLQNPNVFALQSLPAKPWYDYEEFIPEISTLEAALPAIKQEYRELLTEQNISENFEGWLENNVPEGLWSVFHLFNQGKRMEDNCSKCPKTVAILDNLEVFMKDCAFGNAMFSVLEAGTHITEHYGPCNVRIRCHLGLHIPANCTLTVAHQSRQWHEGKCLLFDDSFLHEARHDGRDDKGPRVVLMIDFWHPDVTQAERNALCHLFPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBT9</accession>
    <name>A0A8B7ZBT9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110985951</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110985951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103149.1">
        <property type="nucleotide sequence ID" value="XM_022247457.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985951"/>
    <dbReference type="KEGG" id="aplc:110985951"/>
    <dbReference type="OMA" id="PTGNADC"/>
    <dbReference type="OrthoDB" id="10063988at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4100">
        <property type="entry name" value="Zona pellucida, ZP-C domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3210">
        <property type="entry name" value="Zona pellucida, ZP-N domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055355">
        <property type="entry name" value="ZP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042235">
        <property type="entry name" value="ZP-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055356">
        <property type="entry name" value="ZP-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001507">
        <property type="entry name" value="ZP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002:SF43">
        <property type="entry name" value="DELTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14002">
        <property type="entry name" value="ENDOGLIN/TGF-BETA RECEPTOR TYPE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00100">
        <property type="entry name" value="Zona_pellucida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23344">
        <property type="entry name" value="ZP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00241">
        <property type="entry name" value="ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51034">
        <property type="entry name" value="ZP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034717110" evidence="5">
        <location>
            <begin position="21"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1473"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="ZP" evidence="6">
        <location>
            <begin position="1143"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1391"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1394"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1409"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1437"/>
            <end position="1449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022103149.1"/>
        </source>
    </evidence>
    <sequence length="1509" mass="167393" checksum="B2030003F5A52D29" modified="2022-01-19" version="1">MRAVLLFSICIASSFIELLANRNVGHYKGGSITWKADENNPNNVNVFYRLNFRHHYTNGYLHNQCTDQAIEDRSVLNTEGSFRVDGQWISWAKYICTDYDDAMDWSAGYFIMPYTLEPGQTRVDVNFKECCWPTTVANNGNDQGNGRGWNMVSTIDISPRPDTGRPNSPPVAGSFPVYRLYRGCKYTRYIRAWDADGDMLRCRWTDPNRNECNDDDGDICGELYVNADRTKKGAILEEDTCKITFNRRNPAGTYAVALMIEDYSPSDPSTPLSRIPVQFLIEVHPKDGRCRKPELIGEDGTCTTIPAGRETRIPLRARSSFPDYPITSFETIKPSGVHVTPLRRVDGSNDEYTVTLSWVPTRDQIGRHVICYEAEEAYKFSSDMFCMYVNVVDAADFGPPLVVDPYESTPRPGARLRGDTISIAYSREIRKASRSTFISILEASNNPLYQVDSSSSDVTVSGQTLSFTLPYDLPLQRGTAYKVRVDEGVAKSAVDCEAAPLGDEWMFVFESFCDGDNTPLVVSPAESVPAPGAEMFGNVVSVTYNKEIQQPSSSAYVTIYDRTGSSIFRVDTSTADVTVSGRTLSFSVPLTLSLEHRGWYRLRVDEGAVVSARACEQGFPPMAEWDFVFVTFCSDEEPYEPLTVLPSQSVPSPGENFAGQTVMIKYNKEIQKSSDSAYITMLDAFGFPVLQVDTSSPDVTIDGDTLSFVLSLGLPLQFGGGYSIRVDEGAVRSAQDCDLVPPPPAEWDFVFVTFCRDEESYEPLTVLPSQSVPFPGENFAGQTMMIKYNKEIQKSSDSAYITILDAFGFPILQVDTSSPDVTIDGDTLSFVLSLGLPLQFGGGYSIRVDEGAVRSAQDCDLVPPPPAEWEFGFVTFCPDGGDYEPLSVRPTESSPYPGQNFAGRMMKIGFNKQIQKPLRPAYISLFDSTDTLLFQVDAASPDVSIVEGTSLGFTLPLDLPLESQGEYKLRVDGWAALSAQDCDLSRPDTAEWRFTFLTFCQDGGADFEPLAVVPLESQPRPGGNISGYDVTIQYNKPIRKPLSPAHVRIMNSEESAVYEVDTTSDEVTIEGRALKFSLPVAASVFFGFDYKIVVDEGAARSTKECDVTVPTGADWRFKWTGRTSPAELEKKPVVSSQPTGNADCRENFMQTFVSKRLVGGIDPTSMYLNDKSCTGREYNKTHYVIGTSYDACQTVPEVIGNGRKMAFRNVVYIPPQPYTPGSEITRDHFIEIHLTCRVPTDRISYLSFDPNVTTIVYYEEGYGNFNFSLRMYEDESFARAYRPREFPVGVQLDQPMHFEGRVTCDGNCDLMIDNCWATPTSNPFDVTRFPFITKGCPVDDTVVLLDSPSSKRERFAINSFAFLGDNIHGTVYVHCDMRICDVNDPNSRCTMGCDSDSPSSPGIPSPDDNVLRPEVPNRGDVPHSELPQRRKRDLTRVGSSSAAYPSTGGQLRFDGEKIDANQNQMKMAVNPDVVEIAMLGTIIFLLVVLVFMQCRRTSGAAGKDSTLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBU9</accession>
    <name>A0A8B7ZBU9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11 12 13">Uncharacterized protein LOC110985958 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 12 13 14" type="primary">LOC110985958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103159.1">
        <property type="nucleotide sequence ID" value="XM_022247467.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103160.1">
        <property type="nucleotide sequence ID" value="XM_022247468.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103161.1">
        <property type="nucleotide sequence ID" value="XM_022247469.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103163.1">
        <property type="nucleotide sequence ID" value="XM_022247471.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985958"/>
    <dbReference type="KEGG" id="aplc:110985958"/>
    <dbReference type="OMA" id="NESFTHA"/>
    <dbReference type="OrthoDB" id="10014897at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376:SF235">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24376">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="657"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="711"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1019"/>
            <end position="1053"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1070"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="1328"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1411"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1513"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1897"/>
            <end position="1962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2031"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2210"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2269"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2309"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2573"/>
            <end position="2605"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2628"/>
            <end position="2721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <begin position="188"/>
            <end position="207"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE16</accession>
    <name>A0A8B7ZE16_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450 4F4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103232.1">
        <property type="nucleotide sequence ID" value="XM_022247540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE16"/>
    <dbReference type="GeneID" id="110985989"/>
    <dbReference type="KEGG" id="aplc:110985989"/>
    <dbReference type="OMA" id="VGHEKEM"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF201">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 4, SUBFAMILY B, POLYPEPTIDE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022103232.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40029" checksum="68C897EC0C13D2AE" modified="2022-01-19" version="1">MGRAAAQGHTFDIHGGLVLCTFDVIMRTACSNKSNCQIRTVGHEKEMSVLSACETLLRFIQKRQYGSRLLLNPWIFRLSSNYAEYKSNIKFLHNFAKKLVEDRKKEILQKAEGGNPITKPRDFLDTLVMARDEEGSGLTVKEMVDEVNTFLFAGHETTATFMTWFLYFLSKYPEHQTRIREEVDKMLAGRDSERITFKDLSQFEYMTMAIKESMRMMTAGPLFVRTLTAPYTVDGFTIPEGTLVGIGFHQLHHNPTVWGDDHMEYKPSRFLPQNIAKMDPFSYSPFSAGSRNCIGQQFAMNEIKVFTARILRRFRLSLVKGEPDPIPSMNISSKPLKPLHINLETVCRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF53</accession>
    <name>A0A8B7ZF53_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate sulfotransferase 15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104259.1">
        <property type="nucleotide sequence ID" value="XM_022248567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZF53"/>
    <dbReference type="GeneID" id="110986590"/>
    <dbReference type="KEGG" id="aplc:110986590"/>
    <dbReference type="OMA" id="YIAINDW"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050659">
        <property type="term" value="F:N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019319">
        <property type="term" value="P:hexose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052654">
        <property type="entry name" value="CS_Sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15723:SF0">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="150"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022104259.1"/>
        </source>
    </evidence>
    <sequence length="440" mass="50916" checksum="8F8BD9945013BFEC" modified="2022-01-19" version="1">MMFRRKICKNICVFILPTVIVFGLVLNFSGNWSVEQTQSQPHPHWGIGNDFPVDYDSYDSIDGHVHGRGSLYDHDRTDPKSTSGHKRLEPSLKWTNLSALVAKGTKFKVQRALYRFAPEVFDTFPTEFLPGIKSPCWLDVGTEELKCLPSFFLAGFPKCGTSDVYSKLYQHPGIVRTLKKEPHWWTRQRFNGSSLVEYAGNFQTLAKRISESDLTSKTLIAGDASAATAWKNNHWRFFYPTADEPLYITAELIHQFLPKSKIIFLLRDPTERAFSDYLYINFLQRRNSGWKLPKLNSVTFHADVLVSIATLTSCLNRGNSMRACSYDCTDTLPTRIAVGHYVVYLRDWIQAFPRDQIFVLRLEDWSDNCEKWLPKLYKFLDQEKLSDDTISQICKKKTKNSPRYSRGFRGELQNNTREILDAWYGPLNKELDKFLRDNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFL6</accession>
    <name>A0A8B7ZFL6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Low-density lipoprotein receptor-related protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110986664</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <location evidence="16">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104409.1">
        <property type="nucleotide sequence ID" value="XM_022248717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986664"/>
    <dbReference type="KEGG" id="aplc:110986664"/>
    <dbReference type="OrthoDB" id="21182at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000001">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000008">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1220.10">
        <property type="entry name" value="EGF-type module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056588">
        <property type="entry name" value="EGF_LRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="LRP1-like_beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF14">
        <property type="entry name" value="MEGALIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16472">
        <property type="entry name" value="DUF5050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24468">
        <property type="entry name" value="EGF_LRP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="22"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="30"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="36"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0168">Coated pit</keyword>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="4548"/>
            <end position="4571"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="615"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="990"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1617"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1660"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="19">
        <location>
            <begin position="1705"/>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022102626.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="51679" checksum="A343F78177B76D32" modified="2022-01-19" version="1">MIYVRGAGQYRAPEVPSDLLRSCNTISWDDDIVKIASSNTLRLQVVDEMGGSNRSTLGVLATIAVFLQFFLQAMIIKTLGILLVDMREEFEAATWEMGTIFEFVECVNDFLAPIAGALGMTFGARPTVMISGIMITAGFMVASRASNVLQIALYLNIFVGIGYAFPHVLARANLAQHYDDRQFSLASGIGKTGSAFSLLVLPPLVQLCLDEYGWRGALLVVSAMAANFIVCGALMIPKSRQKEDGQEYQPLPGSRTSQKRSKQGMLAQLKATCVNITRRFDPILMRENKFWVILLFYVLGRIGKSAWIIYFVPHAVEKGFSMQTATTMATVAGLGYIMGITIASLAMFKEKVTSSVAFLLSLALFGISFIIDPWMNSVWLVSANAVLLMMGNASMWAASDVIMKEVLGAEKMANAYGWIGLFSGMCRPIAGFLPGWIFDQTGSYNLAFVIIGIIEMTALLPFIVRRRLDVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHR0</accession>
    <name>A0A8B7ZHR0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MAGUK p55 subfamily member 6-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110986661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104405.1">
        <property type="nucleotide sequence ID" value="XM_022248713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHR0"/>
    <dbReference type="GeneID" id="110986661"/>
    <dbReference type="KEGG" id="aplc:110986661"/>
    <dbReference type="OMA" id="CHARILH"/>
    <dbReference type="OrthoDB" id="65789at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11862">
        <property type="entry name" value="SH3_MPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="5">
        <location>
            <begin position="127"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022104405.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="39489" checksum="95BE7336193BF392" modified="2022-01-19" version="1">MSRAVHVRAFFDYNPEHDSLLPCPEVGLAFKKGDILCVVDRDDQNWWQAYVLNRDGPTGLIPSAELEERRRAFVPKENIYTRQTVACGLIQSKRRRHERYQTRKNYVFDRSDIVIYEEVQEMPPFQRKTLVLLGAQGVGRRILKNKLIDSDYRRFGTAVAHTSRRPREGEENGLDYYFALRPEMEDDIRQNRFLEYGEYADNLYGTTYDAIRAVNRSGKMCVLDINPQSLKLLRNSEFLPLVVFIKAPELESLRMIHEAAKAAGETEKQVTDQDLQKTVDESARLERAHNHLFDVVIVNSNLEETFLQLQQAIEDMASKRQWVPVDWVYDSPLINPTTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJ39</accession>
    <name>A0A8B7ZJ39_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Erythrocyte membrane protein band 4.1-like 4A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein NBL4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110987319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105653.1">
        <property type="nucleotide sequence ID" value="XM_022249961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJ39"/>
    <dbReference type="GeneID" id="110987319"/>
    <dbReference type="KEGG" id="aplc:110987319"/>
    <dbReference type="CTD" id="64097"/>
    <dbReference type="OrthoDB" id="6235974at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031032">
        <property type="term" value="P:actomyosin structure organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13186">
        <property type="entry name" value="FERM_C_NBL4_NBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000116">
        <property type="entry name" value="band 4.1-like protein 4A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000003">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF4">
        <property type="entry name" value="BAND 4.1-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="7">
        <location>
            <begin position="11"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="777"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="877"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="969"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022105653.1"/>
        </source>
    </evidence>
    <sequence length="1023" mass="115090" checksum="DA8B03608357A944" modified="2022-01-19" version="1">MECFGRGQKDAYCSIRLLDETELTVNVQRNTRGSELLNQVFDKLNLLEKDYFGLRFLDSQDQTHWLDPVKAIGKQIKNGPPFILYFGVKFYMENPCKLKEEVTRYQFFLQLRMDMLQGRLPCPFHATAELCAYATQSELGDYDPSQHSVGYISEFRFIPNQTEELEQQITQLHQKLKGMEPAKAEVSFLERARWLDMYGVDLHPVLGHNGVEFYLGLTPSGVVVYKNKAKVARYFWPRIAKVHFKDTEFSLVVLDKDGVEDECIFRLASRSACKHLWKCCVEQHAFFRLPKAGEESPHQRKLSFTKSSFRHIGRTQREALEAASTLNRPEQQVIRAPSRKYHRRPSQTDISLKNGMASDDMCLDSSPSSPNGVILRLSPQPACRLPSHHGLSGRESPTSGVSTRSVPWEDCQQARVGLFTPAGGSPVSVRSSASRQHRHRGRSKSPGPHHRHGDRSDCESEAAYGSRRRSRRSAGLDAGSDHESRHHHQHRKRRSRSRGVSSGSESEYSRQDEGRRHQRRSRERMVSSEDQWHAVEENKLVRGELREGQEVVVKRLKDGALANNLKHMEFQKHIKKDLVDQAQYTEEERSGIPYTDVVLDSGPVNSSNPIRDSHSRTRSKRNEDFSDSNISEHSTRHQSRNTSSKSHQHIRKMKKSQAPTQPDGTPPPPYSHSHIGDPVHTSRDPPLDSRGESGSRGVTVQNGDAVDGKYSGHLTPGGGLFGRHQPGSHQDLPLTNGHQGHDRHPHRLPQANGLHSQQVSSSPTLGMEGLCVAHSREDSGLGNEQEEGLTDRQTLPRRDGQPQGAVRSLRREMDSQRSRSDPIPSAEVCDLRTTLQLTVNGRPGPRPDKQQASRLGMQGYRVVQLHSGGHAINDVTTKQEDSRRGPTTNGGPDYPTKLRPAPAIAYGQSTIPGLGPAPKLAPITINNNNIEVTSEKEVSHLWSEPIRPSHAVVTSSLVDDQDMRVNRDKAGNREDSISEQLPDFPPGYKPNYNRGEKRYSITTQEIIRVSTLQGDHRDLQTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKG1</accession>
    <name>A0A8B7ZKG1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105979.1">
        <property type="nucleotide sequence ID" value="XM_022250287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKG1"/>
    <dbReference type="GeneID" id="110987503"/>
    <dbReference type="KEGG" id="aplc:110987503"/>
    <dbReference type="CTD" id="11140"/>
    <dbReference type="OMA" id="AEQCIII"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000001">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="9">
        <location>
            <begin position="124"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="8">
        <location>
            <begin position="288"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="346"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="248"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105979.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="45058" checksum="E379B9F9C759F042" modified="2022-01-19" version="1">MVDYSKWDHIEISDDEDETHPNIDTPSLFRWRHQARLDRMDEAKKEKERVENESLQVKVKLEQTRKQLEELKTSGNTDKINKVEEELHDLEEQTKKWREKEEELAKKEKLTPWNVDTLSHDGFSSTRINKYKPKEEEMTEEELDKKQARFVQKHEKDIKTYGMYRRWDDTGDFLLEHTELVCEETANYLVIWAIDLMVEKKEGLMEQVAHQTIVMQFMLELARSLKQDPRACIRPFFQKIKSADKKYMESFHEELELFKERIRKKAQERIDRAMKEAEEEMEKERQARLGPGGLDPVEVFESLPPELQKCFESKDISMLQKVVGTMDPADAEYHIKRCVDSGLWVPGGGEKDEGGAGDAAKGGVASENVELDDVAKNEEPTYESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLW2</accession>
    <name>A0A8B7ZLW2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor 25-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104331.1">
        <property type="nucleotide sequence ID" value="XM_022248639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLW2"/>
    <dbReference type="GeneID" id="110986624"/>
    <dbReference type="KEGG" id="aplc:110986624"/>
    <dbReference type="CTD" id="22980"/>
    <dbReference type="OMA" id="IWGKMPP"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022104331.1"/>
        </source>
    </evidence>
    <sequence length="665" mass="75140" checksum="A85D3E08879BCF54" modified="2022-01-19" version="1">MSSRAMRKLHGDRSLDELRSRHQLVDEDVGDGDDDEDARMNGVAAVPINLFDLLQEDDHEDGSDRNERGASSSPGDQKPLRHETAPGAKRKKKRKKKNKQSDVETKTQDAPENEDEIDASVREVNAMLGTLPNGGAGQITVSASAVTMETKAVLAVEHKNLNADNEMRRIFGSNVVRQAEQRRRGRRKTYQRSTWLVSPKAEWPNIGKTGLSMKRLEIKGGYQSFTLEHSKDYQQVQFQFLDAVESLNPQNLTILLQMHPYHIDTLLQLSEVCKMSEDRQMAAELVERALYSIECSFHTMFSLTQGTCRLDYRRVENRAFFLALFRHAVFVGQRGANRTALELCKLILSLDPDTDPLGILLTIDHYALRSEQYQCLIRMYDEWEAHKNLSQLPNFAFSLALAYFHSSQDGDTTKADAMLQTALLMYPSTLMPLLDKCSIQPDATAKKHSFFSALSHCNQPAALNQLIALYIGRNYAMWKVPEVMKWLEVNVRLVLERVDKQDPVVKEYQTKRQMRYRGTPRNVLRHIILSEIKEAVVSLPPELANSPVLSYDPVPPKDSIISYHRPPTQHRASSLRADNNPFAEFFRSLRPSYLPPPPGAIPPEPADLPAADERAGAAGGFLAPNTDLRQSLGSLMDAMRDLLNSLRPPDAQGEEFEEEEAEEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNV0</accession>
    <name>A0A8B7ZNV0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Endothelin-converting enzyme 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110987000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105066.1">
        <property type="nucleotide sequence ID" value="XM_022249374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNV0"/>
    <dbReference type="GeneID" id="110987000"/>
    <dbReference type="KEGG" id="aplc:110987000"/>
    <dbReference type="OrthoDB" id="6258835at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034159496" evidence="8">
        <location>
            <begin position="22"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="10">
        <location>
            <begin position="54"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="9">
        <location>
            <begin position="547"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105066.1"/>
        </source>
    </evidence>
    <sequence length="658" mass="75170" checksum="83DBCB412A984FF3" modified="2022-01-19" version="1">MEFCTVSNFLILILLLGTANGLPCNGPKGPLCLQPRCIQTTADILRVMDLDADPCQDFYQFACGNFAKVSEIPEGETRWTPIRQTQYQNQKLVQKFLEQDGYNYKGVRSEALVKAKTYFRTCMNQTFKAENGFDPLLQLIDSVGGWNLLPERGSAVEGDISRLAYRLAEIYNLGIQLLFAMDIGPDDHNSSLNIVQFQQYGLSLHQPGYYEESKRELLDAFVDLGVTVMTLLRDPRSPRELVETRVDARSRMEDIVEFERAMSRLFVPFPKLQDPLAINNKMSLQKFADMMPDFDLLGYVRHAFGRDIGSDREVLVYTPAYFRKLNDLLRDTPDRVLEDYSLLFMTRSYIKYLPEPFREAQKKYINVLTGATKRPTLLDQCLKEVDRTFGDVTGALFVEEKFSEAAKRKTEEILGYIRAAFLENLPRVRWLDKKAKVITGEKARAMIVKIGFPDWILDPAQLDKYFEGLHVSADNALQNQANYKRFLYVNISEILDFPVDKNSWDVSPGKVSAQYDYSRNELVFPAGILQPPFFSNDLPAWLDFCAIINGETTLYENFADNGGLKIAYLAFQRWRRNSADDLSLPLNLTASQEFFLGMGQAWCSYYTPEAAKIYLDRGYHSPEKYRVIGSLSNLPAFSEAFQCPIGSPMNPAVKCEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP04</accession>
    <name>A0A8B7ZP04_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC110987831</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022106630.1">
        <property type="nucleotide sequence ID" value="XM_022250938.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106631.1">
        <property type="nucleotide sequence ID" value="XM_022250939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP04"/>
    <dbReference type="GeneID" id="110987831"/>
    <dbReference type="KEGG" id="aplc:110987831"/>
    <dbReference type="OMA" id="NMAIEMT"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04021">
        <property type="entry name" value="C2_E3_ubiquitin_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin-protein ligase HACE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF429">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SU(DX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="357"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="568"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="147"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="210"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="222"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022106630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022106631.1"/>
        </source>
    </evidence>
    <sequence length="902" mass="102220" checksum="82F28949128B4A48" modified="2022-01-19" version="1">MADSVPTLSQLVVTIRSAELRDTSNSFFSKGDPYVEMTVDGQPPRKTEVVKKTWNPSWDEHFTVLVKPNTKLEFKVFNHFSIKSDVSLGSAKLELLPLLSKNNGQFESLKHTVDLQPSAKANSQRKGKLHLVLDGLKFSAETMARLGCPIQNGLPPSQPNGDIPPPRSSNSQNGPSNSSSSTRRHSTGHPSPGDIASQAAAVVVASSASTGNISGPVANSNAAPATTGTATETGASSSSTTTAAAAAAATQAVRRRPPPPPPAAGSRPPGRPERGNQVSQGNSTSRQTPAAGGARATPPGNQPAQMPPPTGLPPAGAAHNDINSQPLPAGWEMRLDQHGRPYYVDHNTQTTTWERPQPLPQGWERRRDPQGRIYYVDHNTRTTTWQRPTVDSLRTFQQWQRQHNHLQNTTMQQLQQRLFLPSGSGVEPNDPLGPLPVGWEKRTDQHNRVYFVNHENKTTQWEDPRTQGANMQEDPLPDNWEIRYTKEGVRYFVDHTNKTTTFNDPRPNAAKGPKGAYGVPVAYERSFRWKLGQFRYLCQINALPSHVKINVSRNTLFEDSFHQIMRHQAFDLRRRLFIIFRGEEGLDYGGVAREWFFMLSHEVLNPMYCLFEYANKSNYSLQINPASSVNPDHLAYFRFVGRFIAMALYHGKFIYSGFTMPFYKRMLNRQLTLKDLESIDPEFYNSLCWLKENEIDECDLGITFNADFEVLGKLETVELKENGSNIMVTDENKEEYINLMTEWRFTRGIGEQTKSFLDGFNEVVPLQWLQYFDERELELMLCGMQEFDVEDWYRNTIYRHYTRESKQVQWFWRAVREMDNEKRARLLQFVTGTCRLPVGGFAELMGSNGPQKFCLEKVGKETWLPRSHTCFNRLDLPPYKSYEQLLEKLQFAIEETEGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP46</accession>
    <name>A0A8B7ZP46_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 181-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110987962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106832.1">
        <property type="nucleotide sequence ID" value="XM_022251140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP46"/>
    <dbReference type="GeneID" id="110987962"/>
    <dbReference type="KEGG" id="aplc:110987962"/>
    <dbReference type="CTD" id="57583"/>
    <dbReference type="OrthoDB" id="28186at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040416">
        <property type="entry name" value="TMEM181"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054077">
        <property type="entry name" value="TMEM181_GOLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047843">
        <property type="entry name" value="WLS-like_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31918:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21885">
        <property type="entry name" value="TMEM181_GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06664">
        <property type="entry name" value="WLS-like_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM181 GOLD" evidence="8">
        <location>
            <begin position="99"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Wntless-like transmembrane" evidence="7">
        <location>
            <begin position="213"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022106832.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="62174" checksum="8F19961A89E1D00F" modified="2022-01-19" version="1">MDALNYSFQMPEWKTRAKEGWGYVVRLYDAVQDYIVPKYYHDRSNRSVQMRLYTLTKRHFVLVFVAFFTAFTASVVLGIAGPNIDVYAEYRRQENLPGGPFKLESPHLSRFNRSLWLTSVIEVDNGKGESFQKTFNVSIEIRGLKEDDSVKPISNIFFNHTRTLSCEKGELCEELLLLHVSPVKYYSYVITVYFQGLENAKVTEVSFKFRTYNPSFCEMEIWFRFVFLVLSFIITCMFAHSLRKFSMRDWSIEQKWLSVLLPFLLLYNDPIFPLNFLVDSWVTIILDNIFQTTFLCALLLFWLCAYHGIRKDYAVSPFRFWKFMSDRKWLYFYLPKLILVGVIWVAAVVLACWSQYRTLYDPTFNYKVDGGNFLGLVIFFLCVGSLYLLYLVFLIIRAFTELKSLPYMNLRLRFMTVLMLFVVAVCVAVVIMRFGIGILQNNFISELSTYYKNSAEFLAFYSLLNFYLYTMAFVYSPSKNAHKDSYFKDNPTFSMLNESEDELIYGSDSDDNAVTRPLQNGTSYQESEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPC2</accession>
    <name>A0A8B7ZPC2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Contactin-associated protein like 5-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105251.1">
        <property type="nucleotide sequence ID" value="XM_022249559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPC2"/>
    <dbReference type="GeneID" id="110987112"/>
    <dbReference type="KEGG" id="aplc:110987112"/>
    <dbReference type="OMA" id="DANDDEW"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034613938" evidence="1">
        <location>
            <begin position="23"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022105251.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="36997" checksum="1C026B7F3A6831DE" modified="2022-01-19" version="1">MKVPHLPIALAILAGFLPLCLSGEITSHSNRSCKIFIGNSTMSTYAPVDGYVLKNHVGSIQRLPSPKACFLACLIVHSRHGTARCKSVNYYYQDGSQLCELNNVDSRDWPKDLIAQEGTVFLEVSDDKTSPTSFVSCADLKRRGYQTNGSHIVDPDGPGQGETPSEVKCDMSTGATILQHDSEARQLVHGCEAAGCWIHDVTYYQPMEFVLALINASSWCQQFIQYECFSSVLWRRSGEPIGWAVSRDNGRLANWGGVATGTEGCQCQFTEECPGRKCNCDANDDEWRSDEGFLTDSTKLPIVRLQFGDVGGYRENGYVTLGPLTCFGLGEDDYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPL5</accession>
    <name>A0A8B7ZPL5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110988065</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(3E,5Z)-octadienoyl-CoA = (2E,4E)-octadienoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45244"/>
            <dbReference type="ChEBI" id="CHEBI:62243"/>
            <dbReference type="ChEBI" id="CHEBI:85108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3E,5Z,8Z,11Z,14Z)-eicosapentaenoyl-CoA = (2E,4E,8Z,11Z,14Z)-eicosapentaenoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45224"/>
            <dbReference type="ChEBI" id="CHEBI:85090"/>
            <dbReference type="ChEBI" id="CHEBI:85091"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106987.1">
        <property type="nucleotide sequence ID" value="XM_022251295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPL5"/>
    <dbReference type="GeneID" id="110988065"/>
    <dbReference type="KEGG" id="aplc:110988065"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106987.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="37044" checksum="618C62F95A570CCF" modified="2022-01-19" version="1">MCQIFARRLIDCRESILEGLFDLIHFDLIHCFLKTLSGNNFVGRAVLLRHMTSDAPFNYDYETLAVSQPRDYVKQVELNRPEKRNAMNQTFFREMRECFHQFAEDGDCRAVVLTGAGKVFSTGLDLMDLAQIYSVDMDIGRKAVFLKRKLTEMQDAFTAMEKSLKPVISAVHEACIGAGLEMITACDMRLCTQDAWFQIKEVEMGLAADIGTLQRFPKIIGNDSWLREIIYTARKFSSDEAREKGFVSGVFETREAMLEGALDIATLIASRSPIAVRTSKASVLFSRDHSVADGLHDVSTWNASMLQSEDLMKAISAAMQKTEPTFSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZR52</accession>
    <name>A0A8B7ZR52_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Inositol oxygenase</fullName>
            <ecNumber evidence="4 13">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110988301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12 13">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 13"/>
    <dbReference type="RefSeq" id="XP_022107360.1">
        <property type="nucleotide sequence ID" value="XM_022251668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZR52"/>
    <dbReference type="GeneID" id="110988301"/>
    <dbReference type="KEGG" id="aplc:110988301"/>
    <dbReference type="CTD" id="55586"/>
    <dbReference type="OMA" id="RYNTKYG"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022107360.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="35261" checksum="CBAAD4BBE182BE33" modified="2022-01-19" version="1">MDQETVTILDPSQIYRPDVSEKQFEGTEFKPSAKEVQTFRQFAEHSPEDDPQLAKVQNTYKLMHTHQTVEYVRKKHEQWGKFDHGQFSIMQALEFINTIIDESDPDTSVPNIYHAFQTAERIRERHPDKDWLILTGLIHDLGKVMAAWGEPQWSVVGDTFVVGCAYGDSIVYRKTSFDDNPDLKNPAYNSKCGIYEEHCGLANVMMSWGHDEYLYKVMVENSCKLPEEALYIIRYHSFYPWHTGGDYMHLCNNKDLEMLKWIREFNQFDLYSKCDSLPDLDALQPFYQTLIDKYIPGTLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUC6</accession>
    <name>A0A8B7ZUC6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">FAST kinase domain-containing protein 1, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7 8" type="primary">LOC110989234</name>
    </gene>
    <organism evidence="4 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109160.1">
        <property type="nucleotide sequence ID" value="XM_022253468.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022253469.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022253470.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022253471.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:ribonucleoprotein granule"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="FAST_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010622">
        <property type="entry name" value="FAST_Leu-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013584">
        <property type="entry name" value="RAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF72">
        <property type="entry name" value="LD32258P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06743">
        <property type="entry name" value="FAST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08368">
        <property type="entry name" value="FAST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51286">
        <property type="entry name" value="RAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAP" evidence="3">
        <location>
            <begin position="866"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022109161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022109162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022109163.1"/>
        </source>
    </evidence>
    <sequence length="992" mass="111573" checksum="0546CAEC2FA8FFF1" modified="2022-01-19" version="1">MKGTALSTVCLQTSRSELLRSMASSVASFRIGACILAKSNLRQFGKASVCVRCLHVVKDSAGNVKSKSSVSTQTVTRQAGMHSKVLRNTTRKIPGHSCQAAVERFRGTLPADALLDEISSTTDPTEVLNLTGRHRARLTHVHIFHAFHHIWQLAKLHDGPYLTCFLDAVRRHPEFDALCVLAENKLNDVDGKLLVDTLYAALRLTPEVHHPLVRELRTELNHRLDELETNALSKLAVSLGDMNDNRSPMFCATVRLFSDKLHTVDSIRELSAWMREAIHLVSPPNRQAVFQRASQLLAEANPMDIGDNSIRRIIHTMARSRSVSQPLLNQCAQLLMEMMESIPLKELCMVQSMLRCLNYENKELQDAVHKTIIKKLPACHDPEDLAYAIESIGSVASADIKLLLADKAEEVASVLTPSAISRMSAGLRLMGYRNHQTPLVQKLVRRIKAESSSLQVDGLADIVGFLVRLDSPDPEVFTIIQERLLEILGFAFSPSRVLTVVATLAQLPTLDLLDCTVPKRVRAMMPQLNIAGINYMLQATSKIARKLDKSKLGTLSQEVVELRQELFERAQASIDQITSIYYLNNIVDIVLRDDGHVLVLDAAMKQFTNVLHRMTPQLAVDCARNLFRARYLQRDLMDKIAQVATQKMNKITPMQVLYILSPFCSLNYLPPNAPAFFQACVARCQPFLDSLPTGYLVDLTHILTFLQQFPEPFIRHIFSLDFLTKLDEELETIPDRSMMYRRKLMYLNRTVALECPELQVPWFHEQFSQDLLKKRSLTMDSSLMSIQSSLVEVLGGPQYLRSFVVSPYYYDISFECVLDSDGHPLACADYGSVLNRSEGKVAGTMLADLMQWGTQTKQLPQGAQRVAIDFLPSALFCINSRHTLGMVALKQRHLELMGYRYVQIPHFVWSSQVLAEHEERIEYLRWLIFSPSKGLEEQRPAAAAAKNTGVGLSGVLTDKVRPKLPKNLGIQEEGLLEDEMVLKVLNTFDTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWM5</accession>
    <name>A0A8B7ZWM5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Huntingtin-interacting protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110989426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109492.1">
        <property type="nucleotide sequence ID" value="XM_022253800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWM5"/>
    <dbReference type="GeneID" id="110989426"/>
    <dbReference type="KEGG" id="aplc:110989426"/>
    <dbReference type="OMA" id="SSCTEQL"/>
    <dbReference type="OrthoDB" id="8178130at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17006">
        <property type="entry name" value="ANTH_N_HIP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000006">
        <property type="entry name" value="Huntingtin interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000002">
        <property type="entry name" value="Huntingtin interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000012">
        <property type="entry name" value="Huntingtin interacting protein 1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="9">
        <location>
            <begin position="17"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="10">
        <location>
            <begin position="694"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="935"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="373"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022109492.1"/>
        </source>
    </evidence>
    <sequence length="959" mass="107879" checksum="9DEDF39DDD723043" modified="2022-01-19" version="1">MAGRLSTRRSGDSLEAERQNFIKQQTISVSKAINAVEVPVKEKHARSIIIGSFTDKGLTVFWAAVLRLPLQTTSIMCWKFCHTLHKVIRDGHQNVMKDCQPHAEYIGRLGTSWSHHPDGYGRLVGKYCQLLTNRLEFHKKHPLFPGDLKLASPEADLEKMAQNDINAFFQMSVEIFDHMDALIALEEAVFSTFNLARSLSVAPNGQCRLAPLIQVILDSGLLYDYSVRLLFKLHACLPADTLEGHRTRFLKQFRTLKTFFQTSSNLIYFRNLIQVPSLPDEPPNFFLAAKQSDTYIDPAIILQTMESSTDGSIKDSPPPSVFSEPIFEDFPPRQEEPLSSTAMLLDFSSPQQNGQTSSPQPPTPQRDERDFLIEQLQQEIEELKFELDRIQREDQRIINDLKKRILHLEEELHEHRRLIENSYQENEDLQTKLKEESVKAENLVASAALTDQLEEAEKRARVNEDKFRKMKDVYGKLREEHVTLLRSNADVTKQLNTVMKMTEESQLAKLNAEKFVEQLQQSVEEKSAAEDRLKGKMAAKQKLILVGAIEEAEQMIRQVLTQIDDPAYSTATCTAEYLLTRSDNVDQSLNKLQKNFQGYIQNKDSELNLLIRHISSFSYTLGEYILQGKATSNMAPLNFSEGLSSACKSAGERSLALLETLKDDSQTDGMNKSKQSLEEALKEIIRIAKELLPQESDNQEEFGDLVDQEMQATTDAVDKAAARIAEMLKKSRQADTGIKLEVNEKILDSCNDLMSSIKMLIEKSKSLQREIVAEGRGTASAGEFYKRHHRWTEGLISAAKLVGVGATHLVDASDKLMQGKGKFEELEVCSHEIAACTAQLVAASKVKANRESENLKGLQGASREVASSTAAVVASAKTGAQLIEEGDVNDFTKLSLTQTKRYEMDAQVAVLELESKLEKERVKLAELRKRHYQLAGASEGWDDEDPNAEGFLDLPIPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX36</accession>
    <name>A0A8B7ZX36_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myosin-11-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109969.1">
        <property type="nucleotide sequence ID" value="XM_022254277.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989702"/>
    <dbReference type="KEGG" id="aplc:110989702"/>
    <dbReference type="OMA" id="ENCKQRA"/>
    <dbReference type="OrthoDB" id="5982442at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1567"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1727"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="726"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1595"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1635"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1671"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1764"/>
            <end position="1778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109969.1"/>
        </source>
    </evidence>
    <sequence length="1786" mass="205779" checksum="D59536ECA689FADF" modified="2022-01-19" version="1">MMQRMSSPAVRYRNHGNPVGRSFQEANYKPESRPLPSRYANTTPPRTYDDEDSLITGSGLDTSFELMSATQLREQLRREQQKRRDKEREVDTLKRSTNSLMGRQARHSPTGKMQDSPINGHDSDSGISHTLSNSQGQPKTSPRPLHSSPLLHVDVDASPSRHSARTPAPRSTEEPWGLTGASGALKSLQDGMYESEQRRLTLVEKLREAHETLQRQTERLCESEAKLNDSHYTIENLSTTNEDLNKQIASLQREKDRTVEGRQEIIRQNEKLQQRVDELYQELKMTKFSQESLQAEQRKRDQVVEQTSKALDMMEEENKNFQQMKESMIKETKALRESLQMARAKAEKLELDNKELDKIAEKHELLAAHNAELNSQLVEERRANTDLDQQVDLLRAELMKAREEREVFQNRATQLEDKCADLNAKCVSSSASKERLLQEKLDLQQLLNLATHEKEQMNKTRQTLEGKLTELQLEVTQSKLLVEKKEEEMDKMADELNAVKKVGEVLSLELAAARTSLEKVQEDIKQLSADKRAVQQQQTYWENEAKRLASEKDALDKALEQHKQEFKREREQLEEQHQMIKENMKEIRQEKSKVASKCQELETMLQRANEDLRDDSLQHQEELEEWKASSDRLTASLSRKDSEIMALAEKLEEAQEKHVQLKSELQAARIKQEQYAEYRDEADRLREENKQLTQDHAEDQQVIHLLEMQKNILSKGQSPGGQRMTGEQLQAQVDHLRAELGLAEDKVNELREELARERAQASLALDMPDSVTRRSARSTPVPCHNCQELADQIVKLQELNSLLSERIHRIENDSHQTSARSKTVSELQDKCRHLEEKSQALEEGNRQLSTKVSQLESERRNLQSQAMDSVSKVEYDQLERERTRLKLDCERLKSDYHELEGRHQRFVTDHLSRTLDSTGLGASLTAQDYRDQLEAEIRKLQAENDALKRQIDHLNSQALLADNAKKRSDDKIRILEKEAHEMQAELTKQKRRQSPIPDSESALRSQLVERSHTINQLQAEMAAKNVALETMRQGLDARVDGKNQEIGELMREKEELNETRRRLEQEKLVLEIKVDEQRSVIDQLREEKPRILEDKDTKIAELHAEFIQADRNAKKLENDLRNMQEKLLEKDSELVYLRLQQTTELESAQEDTLKQVKELQGLILKKENELGDLRQELQAKSRDFRELLQAKTRQDLELEQIRDEHAHRVEQLSSANKRQEEEIIALREELNALREQLRRLRDCQEADTENLKERLSEAARETARLKEGREREVTDLQDELMRKESEIQRLLSQKGSEVAGLEEQLMDTSRELSRYKDSKEKEVTDLRNELARRESELTKQIEKKEGIIMALEEELEDEKHRKPRLMKQSMNAVEEELASVKGDLQRVNGMIDIKQSQIDEQNSRLKDLESKREELQRDKAEMRRKLEAELDENMDTIRDLNRKMDQQKTEVELLREKCKALEGQSTDTSVQGDRDEYSKRLESKIQGQEEELHALNRLVTDLQNRNKKLEQTRDTLQESVETYRGRNKKLEEAEKLQKKEMETLKETAGAQCTKCKRLEAQYEEVLGEKESLEEENEELHQEVENLEGLLNIQQHDAKKSQQKPKEAAKKSPVKEEIPVTQQTPKESKRPGSGSGSPSPRGASPVPKKVANPLELAAALKRLSNKTAADAAAKRTSADTSPDSRKGSQDGPSFEASGASIRGLPEAGRYDQNRRASLNAMEARLQALKSSSQVKPVKGILEKKEPGASGDQPKKQARFVLPSSRKFDKPLVVGTKDDSPSDVAHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX42</accession>
    <name>A0A8B7ZX42_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulatory factor X-associated protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110118.1">
        <property type="nucleotide sequence ID" value="XM_022254426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX42"/>
    <dbReference type="GeneID" id="110989795"/>
    <dbReference type="KEGG" id="aplc:110989795"/>
    <dbReference type="OMA" id="MRCKKCS"/>
    <dbReference type="OrthoDB" id="10065946at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.290.30">
        <property type="entry name" value="Regulatory factor X-associated C-terminal binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038308">
        <property type="entry name" value="RFXAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029316">
        <property type="entry name" value="RFXAP_RFXANK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15110">
        <property type="entry name" value="REGULATORY FACTOR X-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15110:SF2">
        <property type="entry name" value="REGULATORY FACTOR X-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15289">
        <property type="entry name" value="RFXA_RFXANK_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Regulatory factor X-associated protein RFXANK-binding" evidence="2">
        <location>
            <begin position="71"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110118.1"/>
        </source>
    </evidence>
    <sequence length="202" mass="23065" checksum="A994EFF87341AE20" modified="2022-01-19" version="1">MSCSVCSSQDGSTTNTPSELDSQLSSERECARSPTLMKQDSISDQQAESSSSLSSSSSSPTCCKEEKVEMTCTVQDCGKSAYKSRRYQLLPWKCKYHRNKTYKETYKRRKAQANQDLFNVEGKSTGLDMQGDRFGATTRQRQGEQVSMLEQVLNEKKMALMQSPVVLEFLQKQQQRKHHQQKHQQKSWGLQQIRGRGQPSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYM6</accession>
    <name>A0A8B7ZYM6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110989631</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109855.1">
        <property type="nucleotide sequence ID" value="XM_022254163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYM6"/>
    <dbReference type="GeneID" id="110989631"/>
    <dbReference type="KEGG" id="aplc:110989631"/>
    <dbReference type="OMA" id="QASGFMW"/>
    <dbReference type="OrthoDB" id="10027994at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022109855.1"/>
        </source>
    </evidence>
    <sequence length="922" mass="102133" checksum="BF2D1D5031B43C5B" modified="2022-01-19" version="1">MEAEKCLYAYDYVDLKDREYVKKHAKKRHLGDIDGKHRYRPRPSTATVVSSLVSLDFPETRAINTTTASRIIADQRKQIRNTFEKTQWKETLHGWSRPSTAMDERVQTPVEVELPQRPQTSVSVSDGTQLQMNQLTLRPFSTGAIRKPSRKPPQASGFMWVRMKRRGSAGANLQFKRITEEIRLQWEEEDKKQRQDHRQEKSQSPRRYDAFAGQWLTFAAGGMDEHHGQGEEEGRGPDSGGVVEAFTGETNSEYYNIEGKIGADVANQLRMGNKIRIGVNGKIQSDSLRVRKWRKEVERAESIASDDSYSWADSDFSKLNGQTTKLMKKDLSPVVPLCWDDQLHRPDVKVIEVKDKPSPSTKPDLSERHPVVFEKLVKDDARPKRGPKLETYRLSHRTKSKRNLDGTESLSNRITVITVDQVDEDRESLCSLDYEEILQRSLEVEPATEDEAPSLLRHPEDGQKIAPTDRVLLSPFAEGLVGEPRNGSVSGIKPSGPSSSPRHSAINTDTRLVTRSMTPKPRTVPLTSPVPSSPSIVSGRPRTGSQTSQRAQSSGSKGRYSFSQPPTPRNLNSPHPNLVKPGQLPRTGVSSINPGIPEGEHEYIKISQPILPGSERTQSRMDNLAAIARVGEKNAIVEDYRGSSVSLGRNPSVTSLDSMDSLNVQGGQVVNQLPDDLTEPPCSCSPEAKRAVSAALSRVSRDSSNVINIPTADMNMSMSDLNSMSDMDPLASYSSFRGSLSSDVAAAEADLMPEEEAETRDLIDEMGSEQVDRATRSLASSPSSQHLPSPERQEVGYIINKVDGLELRQSPGEPREESRKTASAKKPNRTVTFAEEIQTPSVPNCTPESTPRDPTDVDSVKSEVDTDDSSNRPQSSESNQSATDELSVLRSKIKSDLVETQRVTQHDLAALEARGYKGKGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0F7</accession>
    <name>A0A8B8A0F7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">UDP-galactose:fucoside alpha-3-galactosyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110989326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109321.1">
        <property type="nucleotide sequence ID" value="XM_022253629.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022109322.1">
        <property type="nucleotide sequence ID" value="XM_022253630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0F7"/>
    <dbReference type="GeneID" id="110989326"/>
    <dbReference type="KEGG" id="aplc:110989326"/>
    <dbReference type="OMA" id="CINTTII"/>
    <dbReference type="OrthoDB" id="1712432at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="2">
        <location>
            <begin position="117"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109322.1"/>
        </source>
    </evidence>
    <sequence length="334" mass="38064" checksum="7186A62450E8F53E" modified="2022-01-19" version="1">MAAEHVFKVLFFIQSAAFILFIINNSQSPPVMPKPAKNLTVQKPCDCEISYTREVFQTASALKIDDTEDIRGALSNCSLADVKKRPGVVMMTTTNLAYVDVALNMLASVKRVGVCINTTIIAEDNKAYSLLKNYTTGDPAIHVQITNSGEMDTIEHKRTHSSQYYGIMNKRQAYFLSLLEKGFEVLFTDSDTFWFRDPFPYFKGDFDMFLRGTTPTRIIKRTDFCAGFIYLKPTTATIQFVKTWTQVMDNNKKKGSYTPDQIVMNRLLKADRPVHINIKMLESDLFPWGPTFFNPSWQKENHSTVVMHASSIRGHPAKLKKFKEFGMWLVSVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1H6</accession>
    <name>A0A8B8A1H6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110990246</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110830.1">
        <property type="nucleotide sequence ID" value="XM_022255138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1H6"/>
    <dbReference type="GeneID" id="110990246"/>
    <dbReference type="KEGG" id="aplc:110990246"/>
    <dbReference type="OMA" id="AVSANCF"/>
    <dbReference type="OrthoDB" id="6407116at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018379">
        <property type="entry name" value="BEN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033583">
        <property type="entry name" value="BEND3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28665">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28665:SF1">
        <property type="entry name" value="BEN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01025">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51457">
        <property type="entry name" value="BEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEN" evidence="2">
        <location>
            <begin position="344"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110830.1"/>
        </source>
    </evidence>
    <sequence length="449" mass="50226" checksum="783207A2461D2E69" modified="2022-01-19" version="1">MSLRQLYKIPREVLVSFDDKSTSIMPTKLIKNVKPGIESGERVEVLWEGEYLPCEVLRFSDDHSDLLFLQRALSRTKETVAKVQGTNEKRKTTDVQDAETASARNSKTKVRRTTENPQKPQEQTAQTSGASKIKVQTNLKKKGKTQKVKEARTTGTSKAKKLQKRPAKEKKRATVLARFCVDDDDVEAVEEQLERLEPPQSPRDHHGSEETDGPVLALTADDDQAAETPARTSLGSPDTISPEQIPYFPELSFLSDEMNSNMGSPLKDSWSPAYKTSTPAKTPMARISVTDLEMFRKMASQIDDLWKHKFVPDSPSKRSSPVPQVTPPRMGSSRPALSNTASTPSDPPMNLSSLSTEIIADHKDSSSSEANFALSLVRLLFSKEEMKASNCRGVRGKTKLDPVRLNHIKGILKGRTSLPPETFEKYWRRDCFKAIDEGCRRLNRSRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1Z3</accession>
    <name>A0A8B8A1Z3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isochorismatase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110989646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109881.1">
        <property type="nucleotide sequence ID" value="XM_022254189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1Z3"/>
    <dbReference type="GeneID" id="110989646"/>
    <dbReference type="KEGG" id="aplc:110989646"/>
    <dbReference type="OMA" id="QHACANI"/>
    <dbReference type="OrthoDB" id="269496at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd01012">
        <property type="entry name" value="YcaC_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.850:FF:000001">
        <property type="entry name" value="Isochorismatase domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050993">
        <property type="entry name" value="Isochorismatase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14119:SF17">
        <property type="entry name" value="ISOCHORISMATASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="16"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00040688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022109881.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="21720" checksum="BFEFEA92E198004A" modified="2022-01-19" version="1">MAASTKSLGNLAAESTVFFLCDMQEKFKPAIQYFSDIVEVSKRLTATSKILEIPLIVTEQYPKGLGSTVSDLDITHAVGVFPKTKFSMVLPPVEEELQKRPNVKSVVLFGIEAHVCVQQTALDLLAKGLDVHVVADACSSRSMMDRQFAYERLRQAGVIVTTSEAVIFQLLGESKHPKFKEVQALVKAVAPVSGLTPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2I0</accession>
    <name>A0A8B8A2I0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990782</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111577.1">
        <property type="nucleotide sequence ID" value="XM_022255885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2I0"/>
    <dbReference type="GeneID" id="110990782"/>
    <dbReference type="KEGG" id="aplc:110990782"/>
    <dbReference type="OMA" id="NHATNIF"/>
    <dbReference type="OrthoDB" id="2433005at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111577.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30329" checksum="BB1A0823B3BC04F2" modified="2022-01-19" version="1">MIFFPSTDDRTVARMMMPPNQGRKSSTVYRQTFDARVMPAINKKNVGNEDDHFYTARANYVLEFASMVGAEVLAMDNKDKIKVGRTTLAVDRRTRNKRLFPQDDRPNYYDHDFPTPKYLLTPCGYLRLTTAEDPAVTTDEHGRKHYAHPEVGPSFLVNRGPHDEVTIETHIGDVLQMVHSMVAARKTILVLIVDGGCDYNINHPAKEIFYGRLFRDTNLDGLVVTSYCPGHSSLNPIERLWGQVTKALSSVYLFDTLPGIKYLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A404</accession>
    <name>A0A8B8A404_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110990879</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110990879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111655.1">
        <property type="nucleotide sequence ID" value="XM_022255963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A404"/>
    <dbReference type="GeneID" id="110990879"/>
    <dbReference type="KEGG" id="aplc:110990879"/>
    <dbReference type="OMA" id="SYICERE"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034564868" evidence="4">
        <location>
            <begin position="27"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="74"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="5">
        <location>
            <begin position="209"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="609"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022111655.1"/>
        </source>
    </evidence>
    <sequence length="651" mass="72578" checksum="035F8981B0D6E5B5" modified="2022-01-19" version="1">MTHSSNLMRFSVVFCLSLSVIFVTQCVGSCDAGHSTDTDGSENVGICTCTSASDSSTLTCSEEPTDCEVDEVLHRRSCYRFLRGNSDLKSRDDAHRDCIARNSHLVYIESVEEQTFLANHCHRQSPRDSSISAADHYWIGLIPTTNNTWLNRSLAHNDLFEFSQDSKAGCFSLYKSRGEVRLIGENCNRKNQFICERPYECRAGYYVNHEGSCYWFGRQKIFILARDSCRYWGGHLLYIESESELQFIDSHFDSENSARYWIGLITQYVWLDGSRAVYQDFGQREHSNNDDSLCFKLSPIDNFLWYDWDCSSNYSYICEREKTTLSREKQGSSEPCRPSLPNLNRLFDSLPICISSGRDHFDNAVLCQCNDKTTCISGCGCVRDITANGNETAQCSCGSCSFAFDTSENGNGLRWPSNFACICAANGTSSRATVVDGIFTCLTDNLESTTARRIEKRKTSGMTSTPSRVYQVSTENIATGRGGDSDGQVGISVGIPVAVSLVILFFLVALVAGFICWRRRGKRAKKGPTKQLTSDTRVVGSHTINVNPTYTGVCDDHVTEDILKPIAVARQKRVLKPQADTVYSNIKPIDQAASESECYVTIHSNGYTLDKPKDERDVHTTLHGKDSSEAKNTPDPATGYTAYKPQRGNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A4E8</accession>
    <name>A0A8B8A4E8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Uncharacterized protein LOC110991259 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC110991259</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022112260.1">
        <property type="nucleotide sequence ID" value="XM_022256568.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022112261.1">
        <property type="nucleotide sequence ID" value="XM_022256569.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022112262.1">
        <property type="nucleotide sequence ID" value="XM_022256570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A4E8"/>
    <dbReference type="GeneID" id="110991259"/>
    <dbReference type="KEGG" id="aplc:110991259"/>
    <dbReference type="OMA" id="ICERYMN"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035196">
        <property type="term" value="P:miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039691">
        <property type="entry name" value="ZC3H7A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14928:SF16">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14928">
        <property type="entry name" value="MICRO-RNA BINDING ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="757"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="757"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="814"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="818"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022112260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022112261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022112262.1"/>
        </source>
    </evidence>
    <sequence length="964" mass="108198" checksum="C9184523480354E0" modified="2022-01-19" version="1">MSRARFEREEYINNRLTKLKMTPPELLPHGTLLKQFIRDIQKDIKEEGDELIADGEYQAAGSMLTEAINCKDYLKLAGYSCSTTLDKNLHLLRADCAYKLGYPDAALEDCRSALKVDPNSERASWQEVLARFDIIKQEFHRNKNLDIMIGFEVLLSEKPEKILEHPKVKEVIKELNLILDPHKELNHVRRRPKVKSSQNASSRAQNGVAAGGVAMEWVPDHVKANKKTNQKAKASTKNKKKNKTKPLVRELSSEEEESCEESSYESDASSISTRGTRSDSTRKQTCSAATSSNSRSYGLDDFGPIQLPSKSQSNGATPKATSSGPPPEPPGRRASNELLPTRLPPAIVDYANLYCKVCNMQSNAHKQLLQHLAGAKHMAKQAEFMRTQQGHQSAGVQRAPFKPPPAQRVPAQPQHFTLPTKNTYASLSSPDIQGPRPTMLKSPMAPAANQIHPGLPRPATAASVSARAGNIVPHPKISPQSMEWLKKFTFRLACEKCFPTIAGKFGYKGHRYQPHDNHHCYGGWLICRLGSLSHPSEEIWGKIRCRTKPDFMGPYSLCQQFDSGNPCKVGEDNCWYCHSREELMIWDADRAGSFKGKEIVNFLRYSQGIGVKQPKEEPKQDQSGFTVVSHQGSNRAKPVQPYPGTGMGASKMAPIAVPNAAKAVLPEQPKKKPPVDESLRKWHLMLMARVGGHFLYLCGRCFDGAPPVMALRSPTTPFCSNEEGPHPWEQSKVLVHIFNEKGKARYQKVRPKPKGIPARAYLCYNIQKRFGCRFGDSCKFAHNLIEIEVWEFEVLYSLMRDTIVQLCSEAASRQPAQAPQPPASSAPGPTPKAAPPASQPLPTPSVSQAIPKFNHNIQYVCGLCFSRTNQCVGQNPRKRDNCAGSNPHPWQHKIVVVYSVARKRFFPVKPRHPNLRREIHPILCKHLDKCYRAECMFPHCEEESSLWRYMAQYNREYLVSLMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XEH5</accession>
    <name>A0A8B7XEH5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transmembrane protein 237-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110973039</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the transition zone in primary cilia. Required for ciliogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM237 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079154.1">
        <property type="nucleotide sequence ID" value="XM_022223462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XEH5"/>
    <dbReference type="GeneID" id="110973039"/>
    <dbReference type="KEGG" id="aplc:110973039"/>
    <dbReference type="OrthoDB" id="550113at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035869">
        <property type="term" value="C:ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029409">
        <property type="entry name" value="TMEM237"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28388:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15383">
        <property type="entry name" value="TMEM237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="36"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022079154.1"/>
        </source>
    </evidence>
    <sequence length="537" mass="59560" checksum="194F1AD816AFFB13" modified="2022-01-19" version="1">MMQDGLRASLLSRLIPFAWTRTCYRYADASVKRRSLPPLLTSEPGSSSGQAQRPKKKKKKTAEGAADVSDSQQSSVSKQRTLPSEFKVDSPVMGSRENLVQNGQNGADSQAKKPRRKKKMTHGYDFESGADDTVNGEISVSTPAINNLKSSPGSSRRKKAEHRQSRLPRSVSDEVLRDNEAAGSTAKKKPRRPQSKHFADDSADDEDDAGTSKGHGRPPPPGKVKKKRKSKPPTSVDENYHADGEGMSLDIMVAAEDIISPEKQTRDEQQQQQPSHTAVLPSQPVGKLFMERKGGFKGEDKGRLARQRERELNNQQPQAETQKTTTQVALTTHRALLTFSLFCHGLLAGFALWQCVMVYILQRQVPSSDTPGKTRFLEHYSRLAQPASAMYYFLFTVCTVSVFDRFDIGRPDKQFFRGLITFQSGAISILIYLISLIMSASVAAIDDRISLFFKTTPPYCGDTCPESGSLWDSEEADAQLNIWVIINLIRAIGACLGWLVISVTPTTDYTSDHLHDAEEPLWDDQQDVELNNVHSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XG09</accession>
    <name>A0A8B7XG09_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ras-GEF domain-containing family member 1B-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110973316</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079714.1">
        <property type="nucleotide sequence ID" value="XM_022224022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XG09"/>
    <dbReference type="GeneID" id="110973316"/>
    <dbReference type="KEGG" id="aplc:110973316"/>
    <dbReference type="OrthoDB" id="20825at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF356">
        <property type="entry name" value="FI05912P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="6">
        <location>
            <begin position="311"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="481"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="208"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022079714.1"/>
        </source>
    </evidence>
    <sequence length="750" mass="85870" checksum="06D19DEC35A2E644" modified="2022-01-19" version="1">MNPTSFALPSALKSLQTALHGMWRAFLLTCGLIWILIFYSFLFLWENSGTPADLWKSLFVKTAREDFQAREPVEEHMEPAREVRVHVKGHRLDHRNGDLKVSEAVTSQLPIPGALSKGQSCKFKDHGLRRNDFKLHDSNMPIKEQSVLRERPCLLLSQPPSQHGKGVQPSSPNPHQSEEARGQPMKAPNRKGWTICIEESYVSEVRRKPGSTELKDNHVSGDKLKQHEGSLTSSGVNVSGENKEEPSIFGTLTKEKTPKDDSKKRSLPQTSGLPAMFTEKLAPETSSKPCNGQPAQENHHEDETTPALVYQDGNLNSGTLEAFVQHMVPTVDYYPDRTYLFAFLLNSRLFIKPHQLLHDVCQVCIRQQKLGSPDVDRESSKKFSLKLLQLLIEWTETFPYDFRDERMMRHLRDITQKCVAVDQSLRKNVGQLMQALIRKLATLEKYEDVLSRVNAAATERMHSLRTNPAAFQTNIIDVCPSAYVLAQQLTHIELERLANIGPEEFVQSFMKEEKNEAALRLLDLKRTKNLEAYVEWFNRLSYLVATEVCMHIKKKHRAKLIEYFIDVARECYNIGNFNSLMAIMSGLNLSPVTRLKKTWGKVNMDKFEILEHQMDPTGNFNTYRQSLRAAMQRALGAQDGACDKIVIPFFSLFVKDLYFLNEGCMNKLANGYINFQKFWQTAKQVTEFMTWKQVECPYPRDRQGLNYLLTAPVFSENSLYLASYESEGPETNYEREQYKTLKLQCNAANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGF7</accession>
    <name>A0A8B7XGF7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Thiamine transporter SLC35F3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110973103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079306.1">
        <property type="nucleotide sequence ID" value="XM_022223614.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079307.1">
        <property type="nucleotide sequence ID" value="XM_022223615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGF7"/>
    <dbReference type="GeneID" id="110973103"/>
    <dbReference type="KEGG" id="aplc:110973103"/>
    <dbReference type="OMA" id="CPWERRR"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079307.1"/>
        </source>
    </evidence>
    <sequence length="472" mass="51579" checksum="3843264F8EF110D4" modified="2022-01-19" version="1">MEDEKSTELSVPTVDSEFKSKDNLSHGKAVIETSFSSQAENKNGIMTKGDQDTAKANLLDVAATSDEIDAQEATGDGVPQSDVSGRGTRFSENIRKTVFGLIIVIGIAVSWVGATQFTQSTYSPDFSSASVNVWFSTSWMLVCYPVYVLGASVFLPRSRSVEGFKNLYSESEAVFGRRGLCLRTFATLTVPFAACWAVTNYLYVYALGKIAAADVTALFSSNTAFIYIFSWLWLHERLVLLPARSVSVLMSIGGMVLISYADGFEGPTALGISFSIGSAIGSAVYKVLFKRYVGNASSGQVSLFLSVLGIFNILFLWPFIIIFYYTDVETWSFDKIPWDYLCGSAALSVAFNFLINFGIALTFPLFIALGTVVGIPLNAVVDLIFRGKDFSNFKIGGSVLVIVGFLIMLIPENIQQKAACWTEGSCPWERRRRAREDLRADDAGVDNHGAIDAVETKCPEMDEVSVQVDIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGG2</accession>
    <name>A0A8B7XGG2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110973062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022079217.1">
        <property type="nucleotide sequence ID" value="XM_022223525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGG2"/>
    <dbReference type="GeneID" id="110973062"/>
    <dbReference type="KEGG" id="aplc:110973062"/>
    <dbReference type="OMA" id="LNHHDQG"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:negative regulation of pre-miRNA processing"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bin3-like"/>
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    <dbReference type="InterPro" id="IPR010675">
        <property type="entry name" value="Bin3_C"/>
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    <dbReference type="InterPro" id="IPR024160">
        <property type="entry name" value="BIN3_SAM-bd_dom"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315">
        <property type="entry name" value="BICOID-INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12315:SF1">
        <property type="entry name" value="RNA 5'-MONOPHOSPHATE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06859">
        <property type="entry name" value="Bin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
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    </dbReference>
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        <property type="entry name" value="BIN3_SAM"/>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bin3-type SAM" evidence="7">
        <location>
            <begin position="40"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367087"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51515"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022079217.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32894" checksum="2D386256C26C5483" modified="2022-01-19" version="1">MAAPMEAWDRQFHPGAAPFGNFINYYSFNPPEKRIRFLPEDLLNIISYSGRKKNATVLDIGCNSGDLTVALYMHLKKQHLDKKEQGSSKMCLASADENDQDISSNPAAIEPDNTVAIKVLGCDIDDTLITRANESNLHPESISFHRMDFMCDASRSSNLTEFLSRHSETSGRFDLVCCFSLTMWIHLQHGDAGLHKFLKEASLLSRFLLVEPQPWKCYKSAVRRVRKVGIENSWHFKELNIRDKVEEDIINYLTSTCQMELVRTLGETHWERKLFLFRNATGVSDTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHZ8</accession>
    <name>A0A8B7XHZ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Somatostatin receptor type 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110973208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022079550.1">
        <property type="nucleotide sequence ID" value="XM_022223858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHZ8"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022079550.1"/>
        </source>
    </evidence>
    <sequence length="378" mass="42707" checksum="E534A6D9B5BC5EAA" modified="2022-01-19" version="1">MEASTAAYLNGEVMVTVPANSEQVMTPTMTLPERGNFSFALFFFVVLSSLGMVGNAVVCLVMLRNRKVFNSTTNKLIIHQSTIDSFGSIIFLTRRFALITPPVPAGFLTRLYCRIWWSEWVQYSMFVTSTYNLAAISAERYLATCHPVRHRNMFSPCRLKLLLLVPWLAGWLPAAHVVVLSFYDSETLDCGIAWPSLEAQAAGGVLIFLQEMVIPLTIMVFTYSRITWSLQQRSRVRQGENNAAAREMFSKANRNVTITLIVVAVFFVVCWLPNEVYYLLYNLSLQPNFINDPVYEVTSVFVVLNLCINPFIYAFAYERFRKKLLEMLCCRYWSVRRINVLENRTGVQASTVPMVSGGPSKTIHTNKAGSSTQGTEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIA3</accession>
    <name>A0A8B7XIA3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">28S ribosomal protein S7, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110973756</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080524.1">
        <property type="nucleotide sequence ID" value="XM_022224832.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:ribonucleoprotein complex"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14870">
        <property type="entry name" value="uS7_Mitochondria_Mammalian"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
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    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="73"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022080524.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="27055" checksum="E0D00AC106A4FFC2" modified="2022-01-19" version="1">MQTNMALPMGSSRGFLKLGLSEASYGVWIPGFVQVRHSRYPRYYARPVVDQTAYQDGQLPLDVSRPVRAATCDISSSDLFYDPLINKFVNIMNKKGKRQTVKKIMDRTLEKVKREQLVKYNKAPEAERSSVEINPRVIFLKAIENCKPLMGLAVVKKGGKNYQVPTPLTPSRQRFLAMKWILEECSTKPLKVHMPVKLSSELLDAYNNTGKVIKRKHDLHKQCEANRAYAHFRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIQ6</accession>
    <name>A0A8B7XIQ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110973841</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110973841</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080683.1">
        <property type="nucleotide sequence ID" value="XM_022224991.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110973841"/>
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    <dbReference type="OMA" id="NDATWPS"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
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</entry>
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    <accession>A0A8B7XJI0</accession>
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</entry>
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    </dbReference>
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            <begin position="544"/>
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        </source>
    </evidence>
    <sequence length="555" mass="60485" checksum="E38DB63EE78C559C" modified="2022-01-19" version="1">MKLRIRSGGGRTEKVDFDGDPTVAEVKESVAQAFGHHAADFELSLNGREALAPDSSLSHVGIVSGDLLRIIWTNEGAVEIRIPQDQASGSQTCGAVETARGSKPDSVESAMEVSSSSQDRTHPDRARQTVPLVSHDRTSQPSAPTTTTGDAPDLSGCRAAAKDEGEDMRRSVSEPMLCRSATDCVIPQRLRALYTENRPRTMNEALCIVLHVLMLETGFYAKVKVESGDGSLTGSTIDGSPGTSSEKQLKTSSKDDAASSVAKAGMPAGWRVAGVHKLHYCHPSCEGAVCSIACLSVGKKTIVHGLTAGKANFTLQLKPSNYVANVGEQPAYTNLPQLSRLFKDVIAYPLLQTTRSELGLVPLHGLLALFPEIQLLILSFLDVGSLLNVSEVCRQLYNMAADGSLWRQLLLRDFGSKESEGSRNWRELYKQRYKRKKELERYQRNLIDRSTPVTPGMFYPPPSRPPTVPGYPPGYRGGDYDLDPFAGLAPAHHFPIRRDPRGMPFPGQPNIVPFPEEPMSRDPILNPLPRVPGLRDPRRNGQSGRSGGSNRGFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XL09</accession>
    <name>A0A8B7XL09_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Isocitrate dehydrogenase [NAD] subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110973822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080645.1">
        <property type="nucleotide sequence ID" value="XM_022224953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XL09"/>
    <dbReference type="GeneID" id="110973822"/>
    <dbReference type="KEGG" id="aplc:110973822"/>
    <dbReference type="CTD" id="3420"/>
    <dbReference type="OMA" id="TCAHKAN"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="49"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022080645.1"/>
        </source>
    </evidence>
    <sequence length="379" mass="41442" checksum="BBFCA0245B265559" modified="2022-01-19" version="1">MANSSLFCKILTRTGLKLPSVHLLVRTLAISQACQKPVAPVAEPDTKRTVTLIPGDGVGPELMLSVREVFKSAEVPVDFEELFVSEVQVGKSATVGDVIDSFKRNQVALKGIIHTPWGGGGELQTLNMKIRRELDLFANVVRCRTLPGIKTRHTGLDFVVIREQTEGEYSALEHESVPGVVECLKIITRANSMRIAKFAFDYARRNDRQKVTAVHKANIMKLGDGLFLESCRQISTLYPKIQFESMIVDNCCMQLASNPHQFDVLVTPNLYGNIVDNLAAGLVGGAGVVPGESYSTEFAIFEPGARHTFSQAVGRNIANPTAMFLCAANMLKHLHMDSYAKLIQRAVESVVSAGKVRTQDMGGYATTSEFTSAVVNNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XL23</accession>
    <name>A0A8B7XL23_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox protein SIX6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110974277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081504.1">
        <property type="nucleotide sequence ID" value="XM_022225812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XL23"/>
    <dbReference type="GeneID" id="110974277"/>
    <dbReference type="KEGG" id="aplc:110974277"/>
    <dbReference type="OMA" id="PAGICCV"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF33">
        <property type="entry name" value="PROTEIN OPTIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="133"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="135"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="160"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081504.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="30171" checksum="7E8C6A00A9FFE426" modified="2022-01-19" version="1">MLGSMFPLPTLPTLSFTPAQIASVCETLEESGDVDRLARFLWSLPVAPGTCEALNKNESVLRARSVVSFHQGNFRELYHILENHRFTKESHAKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAHATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQQQQQQQALQNSSANANSGPPIHRLSMTEGTTTLPGEESPDSGSPNVSPIGSPLLPRSVSPRPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLR9</accession>
    <name>A0A8B7XLR9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Transmembrane protein 169-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110974437</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081757.1">
        <property type="nucleotide sequence ID" value="XM_022226065.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081758.1">
        <property type="nucleotide sequence ID" value="XM_022226066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLR9"/>
    <dbReference type="GeneID" id="110974437"/>
    <dbReference type="KEGG" id="aplc:110974437"/>
    <dbReference type="OMA" id="GWIHRIV"/>
    <dbReference type="OrthoDB" id="10066407at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029386">
        <property type="entry name" value="TMEM169"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31777">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31777:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15052">
        <property type="entry name" value="TMEM169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022081757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022081758.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="29392" checksum="2F32FB69B4149A09" modified="2022-01-19" version="1">MPKTPFRKHVKFVSIDNNGANGPENAVRDGQVSAQSQRTESPIGGGPSSFQTEEITEIRVEDEDGVSQPHRFHPDHAREHCSECHMLGKPHKHQRVTATDQDDDDEDGCIYSPQQGPHIIILTFLCIPFVFATALVVNTYLGILTWYNIFLYYYDDRGWIHRIVVCPVLILLCPPVILVTALVVSLYSSVRQLSWYLSSWRTSVTDLEKGFYAWLCHQLGLPNCSPYEVITLDDYEEDSFGRTTSCTHASSGWKKSKALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMG2</accession>
    <name>A0A8B7XMG2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-4C adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110974201</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081352.1">
        <property type="nucleotide sequence ID" value="XM_022225660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMG2"/>
    <dbReference type="GeneID" id="110974201"/>
    <dbReference type="KEGG" id="aplc:110974201"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022081352.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23066" checksum="2D90FCE5AC91FDAD" modified="2022-01-19" version="1">MKAIYTYPELVFCAVAISILITVTLVGNSLVLVAVARSKELQNATNVFVVNLSVTDCLASFAMLWSVPGLVSKTPGYPLRSNVPCVAAAGLVFIANGCSVLTLVNIALNRCILITRPKETYQWLYTPKKIAMMVLCSWLVTACGFILPPIRRAPKDSETRKAVSHAQFDHEYVGHILEICCCGNHHQAVTHDCQGCQDGEPDGTEDQLWVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMH6</accession>
    <name>A0A8B7XMH6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myeloid differentiation primary response protein MyD88-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110974581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022082019.1">
        <property type="nucleotide sequence ID" value="XM_022226327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMH6"/>
    <dbReference type="GeneID" id="110974581"/>
    <dbReference type="KEGG" id="aplc:110974581"/>
    <dbReference type="OMA" id="QHLMCLE"/>
    <dbReference type="OrthoDB" id="10037120at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070976">
        <property type="term" value="F:TIR domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035325">
        <property type="term" value="F:Toll-like receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002755">
        <property type="term" value="P:MyD88-dependent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008063">
        <property type="term" value="P:Toll signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08312">
        <property type="entry name" value="Death_MyD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000029">
        <property type="entry name" value="Myeloid differentiation primary response protein MyD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000005">
        <property type="entry name" value="Myeloid differentiation primary response protein MyD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034249">
        <property type="entry name" value="MyD88_Death"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017281">
        <property type="entry name" value="Myelin_different_resp_MyD88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079">
        <property type="entry name" value="MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15079:SF3">
        <property type="entry name" value="MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="7">
        <location>
            <begin position="189"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="8">
        <location>
            <begin position="318"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022082019.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="50588" checksum="91C62450972AFD6D" modified="2022-01-19" version="1">MSTSPAFSEKRDQEASAYLYPGRTLGGNATIGTCTYSSQVVTPVDSDTHKTTKIETTTALGRTEPIACLFPNSGSSSASNSYRPCSDSQVTESVRSKPTRPGTNANMTNRMSGYDYSPHGSNTETMSSMTSSRSTQADQLSKVDMLSTCSRPTGLRVNLPSTGSTNIDASELDLEKIPARALNVPTRTRLSLMLNPPKVLHNDWTGLAGEMGFEYEEIENFALERDPTKMVLSAWTCQQGSTIGVLLEMLRDINREDVLNDIQKLVERDASRWLERRRGDITGQPVQVPEVSGSYPNVPETPELRGITLEDHVSGPPEVFDAYVCFTDADREFVKEMMTVLEKEPYNLKLCIDFRDLVPGGSYSTITAELIENRCKRMIIVLSPDFLTSEDCNFQTKFAHSIAPSARSKRLIPVMVENCKPPNILRHLTICDYTKKDLRQWFWRRLYSALTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMI5</accession>
    <name>A0A8B7XMI5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dynein light chain Tctex-type 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974589</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082029.1">
        <property type="nucleotide sequence ID" value="XM_022226337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMI5"/>
    <dbReference type="GeneID" id="110974589"/>
    <dbReference type="KEGG" id="aplc:110974589"/>
    <dbReference type="CTD" id="6993"/>
    <dbReference type="OMA" id="VNQWTSA"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21462">
        <property type="entry name" value="DLC-like_DYNLT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.40:FF:000001">
        <property type="entry name" value="Dynein light chain Tctex-type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082029.1"/>
        </source>
    </evidence>
    <sequence length="113" mass="12709" checksum="C6CA0B8AE3B7ED88" modified="2022-01-19" version="1">MEEYQTPEETSFVVDEVSNIIKEAVEGTIGGNAYQHNKINQWTSNVVEQCLNQLTKLGKPFKYIVTCVIMQKNGAGLHTASSCYWDNMTDGSCTVRWENKTMYCIVSVFGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNJ9</accession>
    <name>A0A8B7XNJ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110974433</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081752.1">
        <property type="nucleotide sequence ID" value="XM_022226060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNJ9"/>
    <dbReference type="GeneID" id="110974433"/>
    <dbReference type="KEGG" id="aplc:110974433"/>
    <dbReference type="OrthoDB" id="8182187at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022041">
        <property type="entry name" value="Methyltransf_FA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36695:SF12">
        <property type="entry name" value="AGAP008648-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12248">
        <property type="entry name" value="Methyltransf_FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Farnesoic acid O-methyl transferase" evidence="1">
        <location>
            <begin position="76"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081752.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23719" checksum="7A23437DAEB24F8C" modified="2022-01-19" version="1">MAGGKMISKSPRNLTRRGRCAYRRSGTIHGAAKTRHAVMLMMVAIVCLYQIETVTTTDDCQRRLKPSHTHLEFDREVTSLNRVAFTVKTDKEAIIGLSPSSLGVDPVMYKIVIGKAETGKSEVQRCQSSCSSWVMPVAIADILSPTESRGFWIDWGNGNGLIKVGRRGEETPFMERTEPDPSPIAIRYLGYATGASSGESTWNFCGESDFCRCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNX5</accession>
    <name>A0A8B7XNX5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">G-protein coupled receptor 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110974891</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082514.1">
        <property type="nucleotide sequence ID" value="XM_022226822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNX5"/>
    <dbReference type="GeneID" id="110974891"/>
    <dbReference type="KEGG" id="aplc:110974891"/>
    <dbReference type="OMA" id="ICKAREW"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000072">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF79">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="14" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="673"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="21">
        <location>
            <begin position="527"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="734"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022082514.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="85441" checksum="71604D1405CA9B91" modified="2022-01-19" version="1">MGKVYILTDLSRLEKALPKNAAGTALHVAGLFPLSAPGWIGEYGLQGLTAVELAIRQINNRSDLLADYQLVLDYNDTKASSAVAMTALFDLYHREPVKIAVLGELLSTVTRDVTGVTSLWALTQMAFASSAIELSVRSTYPYFFRTIASASEIPPVQLEIFRQFGWGKVATLHETKEPHNGVSRELQRLLEANANFSIIAAESFSEDPTEALRRIKTKDARIIVGNFYESTARKVFCTAYKLGLYGAKYQWFVIGYYTPEWYNRATADESVRCNSSMIQEAAEGYMTVTWSMNGRVDKMTVSGQTPQEFRNHIRDTTGLTIGLDGQDPAANAHDGMWALALGLNSSLNELHPRRLESYVYKDRRMASILEKHIRRVRFYGVSGPVSFSARGDRIGLFLIEQNRGGQEVVIGTYEKDEKISWIISAAKIWYQNGGNPPFDSDNTKTISFPHVIDPVVFITSCVIAGVGCALAICFVTFNFILRKHRQVKMSSPRLNNIVATGLVFAYTSVVIMGVDESVVDRPQLLNICKAREWLLSIAFTLAFGGMFTKMWRVYSVVVHNKTKRKVIKDHHLIAIVGVLLMIDLAILIPREIVDPQTIVVVTRKIPQTPEDELNFIRREEVLVQCTSTHNIIWLMALLIYKAFVMVFGAFLAWQTRNVNVSGLNDSNYVGLSIYNVCLCCVVVVPVSVLVTDAVSVTYALLAGFVMFCTTATLCMLFFPKVAAVYSTRGSTVQPTERIHPSTVSSQHGPRDTLGKPGPSRAETSSVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XPR4</accession>
    <name>A0A8B7XPR4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">N-acetylglucosamine-1-phosphotransferase subunits alpha/beta</fullName>
            <ecNumber evidence="17">2.7.8.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">GlcNAc-1-phosphotransferase subunits alpha/beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Stealth protein GNPTAB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC110975033</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(4)-[alpha-D-mannosyl-(1-&gt;2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-[6-(N-acetyl-alpha-D-glucosaminyl-1-phospho)-alpha-D-mannosyl-(1-&gt;2)-alpha-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + UMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13581"/>
            <dbReference type="Rhea" id="RHEA-COMP:14507"/>
            <dbReference type="Rhea" id="RHEA-COMP:14508"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:140357"/>
            <dbReference type="ChEBI" id="CHEBI:140369"/>
            <dbReference type="EC" id="2.7.8.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the stealth family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.17" evidence="17"/>
    <dbReference type="RefSeq" id="XP_022082814.1">
        <property type="nucleotide sequence ID" value="XM_022227122.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975033"/>
    <dbReference type="KEGG" id="aplc:110975033"/>
    <dbReference type="CTD" id="79158"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003976">
        <property type="term" value="F:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046835">
        <property type="term" value="P:carbohydrate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016256">
        <property type="term" value="P:N-glycan processing to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21599">
        <property type="entry name" value="RRM1_GNPTAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21600">
        <property type="entry name" value="RRM2_GNPTAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.320:FF:000002">
        <property type="entry name" value="N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041536">
        <property type="entry name" value="GNPTAB_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031356">
        <property type="entry name" value="Stealth_CR4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18440">
        <property type="entry name" value="GlcNAc-1_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17103">
        <property type="entry name" value="Stealth_CR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50258">
        <property type="entry name" value="LNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1836"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="25">
        <location>
            <begin position="423"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="DMAP1-binding" evidence="26">
        <location>
            <begin position="669"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="1633"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="778"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="834"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="894"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="936"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1105"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1247"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1307"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1438"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="787"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1105"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1134"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00070893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022082814.1"/>
        </source>
    </evidence>
    <sequence length="1883" mass="215080" checksum="3124F2A4E46ED0EE" modified="2022-01-19" version="1">MYKLVQKQTYTFLSHRHGMILIFIGFIIVVISVIHFGESSLEWSRDQYSQLFNIYHDNIAGKAFQNRMCLPIPIDAVYTWVNGSDPKLIADLQRVKEKLEKDSKKDSEEEEKKLIQCKDDNCVPGPLIVFSAVLPGSPQTEELARSHIAFLQQDRAFNLTKSGRENMTVAQFEKQSVVDVIMKEKPFVMYKGRNISLSRGFLTSDWRAEGGVELKDMAFVSNIGKNVTEEQLQRKIPEDQRENVRHIDLTSSAGVAVITLKTAEVTRVFITEFEKSEGENGMKVGPAYLLWGLEKDTDHEEDISKSRFEDNEEMRYSLRSLEQNAPWIRHVYIVTNGQIPSWLNLDNPRITLITHEDIFPNKSHLPTFSSPAIESHLHLIPGLSDKFIYLNDDTMFGVPVWPDDFYTHSQGQKVYLTWPVPNCAEGCPPSWIRDNYCDTACNNSECDWDGGDCDGVSKPGPVGGGVGGDVARDTPDLYCNPGCANSWIADRYCDQTCNVAKCGFDAGDCGVDNFPHLFGVDIKGPVNITIPKGVTAFFLNLTVVFDTNSSITEAQYDDHKIVRTATVAQKYKLITVLLHENVSDTLIGVNVSGRRNDDTLLSVSFNMTVNSIPVTEKALTVVKEGEEKTVTEKEDEMSKVVFHDIPEHDRGPQIHLNANKPAVEMPAIDLESLSEEIALKLAELNKKFSDGDITEKGHKKYKAQILQEYIQSPEYANRVAGKPETIKETGVHHQEGDFQEVLQNANGKSLPKPGVAKSGGEESIDGFKRLKFRHIVPKPGGQDAVELGEKREAELPGGNVRDKNVDQKDEMLMKKFDVNLQQLDLQQPFMQQQLQPSVQKQQRSMQQQQPVVQQQQPNLQKQPLAQQQPGLQQEQLVQQQHQLGLQQQPIMQQQDKPLVQQQQPFVQQQMHQQPGLQQQPLAQQQQPFVQWQQPGLQQQQPGIQQQPPVQQQPDLQQQPLMQQQDKPFVQQQQPGLQLQQPGLQQQPLMQQPGKPFVQQQQPGLQLQQPGLQQQPLMQQQDKPLVQQKQPLVQQQQQPVIQQQPLAQQKLPQPKSQSQPLDQQQHHNGQQQQPYLKQQPRIQQPEINPQQQQVNAQQFPQEQQLPDLKQQPQQVGIQQQPLNRQQPFAEEQKQHLGLQRLQQQQLGDSEDSKFVGAGGGEVQPKQAAMDHLNYHDNKREVANQEAGGDPLGARINPRRPPNINNLQPVLFNRKPPQQAGWNQIGQAEQHGPQNWREPILINQEPVAHNRKKQRGDQGIPADRNQPLGAGNQLPLSQDRVNPLALNRPAQQLPADEKFQLPETRLQKQEGAVKEAAQQDVGKRTGLNQPNSDPAKLDQGQGNMAPLQPNLVPKDEEQKRIVGDDIPKKKFYKGRRKETGRKFIPQHEDNILHQRKLLSVGNYQPDIDQHNENRPFLKESPYLNIAHFFSAALSNLTSSRLQNSQGEPQKNRVHLGIGQKHPGKQFVEMRDNAADRDRIYKKSDITVGRGTRLKKHERGAVAVTMDDVTDEEAEQLVEDADQYLRKTSFLPWERKEAHQEKRKKSDYQTTSYRSRKPLDTFADSLIHVNRIYNKRFGFIARKVPGHIPHMIDINIMKELQAEFPDEFDATSSHQIRHSKDMQFAFSYMYYVIGSPKEVNTNEIFDEFDTDHSGVLSDREIRTLATRLFELPLDLQTLSSLENNFIQCAKNLSREVYEDPSLTQEKYYEEKMPQVTKALVAKCSAVTDLMQKSVKGQTNYKYEILGDEDIAFKMIRTNVSQVIGQLDDIRKNPKKFVCLNDNIDHASPEAYMVKAVLQDFYEALFPIVSQFELPREYRNRFLHVDELREWRRYRDWLRFWTQLSLLALIAFSIASFCSRQLLALKRRCCPRRRTKMSEIAEKVQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQZ8</accession>
    <name>A0A8B7XQZ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein CEBPZOS-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083269.1">
        <property type="nucleotide sequence ID" value="XM_022227577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQZ8"/>
    <dbReference type="GeneID" id="110975252"/>
    <dbReference type="KEGG" id="aplc:110975252"/>
    <dbReference type="OMA" id="YYRMNTD"/>
    <dbReference type="OrthoDB" id="5804148at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037764">
        <property type="entry name" value="CEBPZOS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38001">
        <property type="entry name" value="PROTEIN CEBPZOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38001:SF1">
        <property type="entry name" value="PROTEIN CEBPZOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022083269.1"/>
        </source>
    </evidence>
    <sequence length="88" mass="10317" checksum="426E81387715D7A7" modified="2022-01-19" version="1">MWGAEALWRFSKYLIAAEIAAFGGAYYVWHKMNISQDYRKHMHENHPYVLELFYRTAEMAQIKDARPNDYRAWGILGNADIDTNTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRE0</accession>
    <name>A0A8B7XRE0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110975013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082757.1">
        <property type="nucleotide sequence ID" value="XM_022227065.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082758.1">
        <property type="nucleotide sequence ID" value="XM_022227066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRE0"/>
    <dbReference type="GeneID" id="110975013"/>
    <dbReference type="KEGG" id="aplc:110975013"/>
    <dbReference type="OMA" id="YNGSWWD"/>
    <dbReference type="OrthoDB" id="438211at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03127">
        <property type="entry name" value="tetraspanin_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF544">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022082757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022082758.1"/>
        </source>
    </evidence>
    <sequence length="261" mass="28724" checksum="29653F352EB42C5B" modified="2022-01-19" version="1">MVNLESPVSTLNCIGRCYKWTLYAFNVLFMFSGIAAMGVGVWGIVDNTSQRIVVLTNSEMYVNASFCLIAAGSAAVFVSILGCCAVRLESKCLIFAFAALMMLIFVTEFAGGVLSLAYYTQVITLANMEMREALVERYGQGTHFETTDAFNYVQLMFDCCGFEGTDIEAAQLYQISKWFENNLILVPPSCCTRDEEGEPVNLQACQNMFNTHLSYINNIGCRDAVAEEGGRFAVVIAGTGIGVSMLQIIGMILAFCLYRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRL6</accession>
    <name>A0A8B7XRL6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Gamma-butyrobetaine dioxygenase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110974962</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082645.1">
        <property type="nucleotide sequence ID" value="XM_022226953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRL6"/>
    <dbReference type="GeneID" id="110974962"/>
    <dbReference type="KEGG" id="aplc:110974962"/>
    <dbReference type="OMA" id="VHITWPN"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="UniPathway" id="UPA00118"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008336">
        <property type="term" value="F:gamma-butyrobetaine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2020.30:FF:000002">
        <property type="entry name" value="Putative gamma-butyrobetaine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF33">
        <property type="entry name" value="GAMMA-BUTYROBETAINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="11">
        <location>
            <begin position="97"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="198"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022082645.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="52654" checksum="3D523BEFFFF5039C" modified="2022-01-19" version="1">MAQAIAKPHALARHALTIRRSVLGLRQSVAPVVVGASAGQPHSRKAWNAAIIPSVLGSLGPRMSHSSQAAPGSRESPRFESFARDDTVGCYRVGLSSGPEGVYPYVWLRDNCRCPDCYHPSSGQRTCDPAEMNPDIKPASEAILDDGKVLQITWPDQHRSDFGVAWLNRQRFSNNERDTVGSPELEMWGGELNGKIPAFDFEKLFQDDLELYNWLEVLNTKGLALVKRAPTAQGILQELSEKVAHVKTTNYGETFQVFSKHNASSVAYTSKSLCLHTDLPFYNYAPGIQMLHCIEQTSDTNGGANQFVDGLQVAEQVRQEFPDLYKILRTQEVDFRNIGSDYYDYHMKQRRPVIEHNKYGEFTSVNFNNQVRAPYLSLPAEKVRDVYRALKVFYDVMYRPENLVEYRLVAGEIATFNNGRVLHGRNSYTVTKEGNRHLEGAYMDWDEAHSRMRILRENLFGDERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRV1</accession>
    <name>A0A8B7XRV1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Unconventional myosin-X-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110975414</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083578.1">
        <property type="nucleotide sequence ID" value="XM_022227886.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975414"/>
    <dbReference type="KEGG" id="aplc:110975414"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13202">
        <property type="entry name" value="FERM_C_MyoX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17206">
        <property type="entry name" value="FERM_F1_Myosin-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13296">
        <property type="entry name" value="PH2_MyoX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051724">
        <property type="entry name" value="Actin_motor_Myosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041797">
        <property type="entry name" value="MyoX_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049">
        <property type="entry name" value="AGAP003327-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46049:SF3">
        <property type="entry name" value="MYOSIN VIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="9"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="955"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="993"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="1176"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="12">
        <location>
            <begin position="1461"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="1625"/>
            <end position="1972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="7">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1245"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1311"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="746"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1271"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022083578.1"/>
        </source>
    </evidence>
    <sequence length="2001" mass="229895" checksum="C563B0396EF614C4" modified="2022-01-19" version="1">MAILHSPSVGLEDMAKLTDLQDHSILENLKLRYDHDQIYTYIGSILAALNPYKALPSYYDKDVMLAYDKRHIGELPPHIYAIANDCYYSMWKRNDNQCVLISGESGAGKTESTKFILKFLSEMSQASSQAGVPQALTGSKLRVEEAILQSSPIMEAFGNAKTIYNNNSSRFGKFIQLQFSNEGSILGGTIQDYLLEKNRVVGQNPQERNYHIFYCLLAGTSPEQKKKLFLRDPTSYSYLNKSGCISDPTINDAENFQAVLEAFSVMRINSEQINDILSLLSAILTLGNVQFITAGGAQVKDMQPIQIVSALLNVDEYQLCDALTQKTRLLRGELISTPLDVDQAVNSVDSLAMNLYGRCFKWIIHRINRCIKGKEFFHSVGVLDIFGFENFEVNRFEQFNINFANEKLQEYFNKHIFSLEQHEYNAEGLEWVDIDWQDNGECLDLVERKLGILALINEESRFPKGTDETMLEKLHSNHAKNAFYIKPKVADSNFGIRHYAGEVFYHTKGFLEKNRDTFRDDILTVLKESRSDFIYDLFETMLQSKNLGDDKMMRKKPTVSSQFQESLHALMSSLNACNPYFVRCVKPNPYKAAAQFDAQLVVNQLRYSGMLETVKIRKAGFPVRRPFPDFVVRYRALVYREDQSQPPGRLCEQLLARLDDRKQLWQMGKTKVFLKESLETRLEKDLKQELGVLASKIKAHIKGYLARKRFKKILAQVVIVEKTMRMQHCRRRYLKVRSAVIVFQKYERARVARKILEHLKEEKRKEEERLREEQRQREEQERRELERLKAEEKMRELEELKRKLEEEARQRQVEEEAQRRLEEEQRQADLEKVRQLEIARKQEEEESRRKAEEQRLALEEEARKLAEEQEKLRMEEEERRLLEEVESHQQELDRLRAEQLERAERQIMHEFDHSIAQLAAQESHDFYSALEQPAELEVEDSEEDDENASKKSEDTHYFEGFLQMKTGGMVNSWKKRWFVLRDETLMWFKTKQEALKSGWLMKKGGGTGTLSRRNWRKRFFILKDTMLSYYESDGNNAKLLGKIDIKASRRITDSSYGRENSIDVETNDRTYHLVAESADDCSEWFSILTRVKNSQDYELKQMHDEEANPKNAIGSLDVAIIDSVVPVNIAERPNCFAIITAERVINLQSESPVGMNNWLAALTQYHKGKRTHKQEDILLGGWLTKESASTGTLARVSMGSRKKRYFVLTANSLEFYRSVELEQKMGAIALNSLCSVTLPDEKIFKEEACPPPTSNPSSPSPKKSRKKSPIQYISSPTQDSLSQNSLSHNGSTQSLNSLNFKSSTNSLVETLIRNKKKKRRGSLGNILSNGVMPTDTPTQSNGIKATPPSSPAQGQSNSNSMRRRSNSLVSTLMRSSKRLSRLDREGYWKFTVHGRNCSFNLYTVSYDEAWKWTYAIQDVIDSKPKLETPFQILIRDIKEAAMAGDLTSIERIFRLNPILRNTPHPLKAPLLPLPYGMIVSSSQEKGYTTLNDEGVKIFNSLLGSENLPDPMPVIQGILQTCHDLKPLRDEVYCQIIKQTTGVTDPDGLGNLRNWQILACLCCSFLPSRNILRYVRFHMKRQIELFPDTQTARYAEFALDSLKRTRTRDFAPSRSEVIAILGRREMSATVFCHGEGSCQININSATTAGQVVHTLVKGMGLDKCHNRFALYERSGHVEKAIEDRTVIADVIAKFERYKARGLSDRGKPWQLFFKLFCFLDTKNVSQGSIEYSFLYEEACEDVIRGFFPTTPEKLVYLAALRTQFIRGDYVQNDWIRDLSEVYPIDRLKTQPKKEETDYAGFPMKQRKENIISGTLRGLGEKTLKKLQKSASDDSILDSVYADEISATTTLVVDKWKTLKGMSPEKAQEAYMSVIQQWKYYGARLFEVESTDGRFPPNLWLAVSSSMVAVHKQGEASPIEEIPYEKILSFGAPIPNEYKIVVEGRRHELSFETNQVFEIAKLMKAYINEIVRKRQSVVSIQNGGIPYQGTGNILDPVTQDTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRY4</accession>
    <name>A0A8B7XRY4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein lin-7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110975427</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lin-7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083613.1">
        <property type="nucleotide sequence ID" value="XM_022227921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRY4"/>
    <dbReference type="GeneID" id="110975427"/>
    <dbReference type="KEGG" id="aplc:110975427"/>
    <dbReference type="OMA" id="RFDKQRM"/>
    <dbReference type="OrthoDB" id="10056216at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097025">
        <property type="term" value="C:MPP7-DLG1-LIN7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06796">
        <property type="entry name" value="PDZ_Lin-7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000076">
        <property type="entry name" value="Protein lin-7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017365">
        <property type="entry name" value="LIN7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038039">
        <property type="entry name" value="Lin-7_homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="L27" evidence="12">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="11">
        <location>
            <begin position="100"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022083613.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23708" checksum="06BDCE34D13B2394" modified="2022-01-19" version="1">MTSVASKMATTAELTLERDVSRAIELLQHLQQNNRDIPPQKLIALQKVLESEFFTAVREVYEHVYETVDIQGDPEIRANATAKATVAAFAASEGHAHPRVVELPKTDEGLGFNVMGGREQNSPIYISRIIPGGVADRHRGLKRGDQLLSVNGISVEGEQHEKAVELLKSAKDRVKLVVRYTPKVLEEMEARFDRQRAARRHNANQMSSFENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSD8</accession>
    <name>A0A8B7XSD8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain family 4 member M-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083774.1">
        <property type="nucleotide sequence ID" value="XM_022228082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSD8"/>
    <dbReference type="GeneID" id="110975528"/>
    <dbReference type="KEGG" id="aplc:110975528"/>
    <dbReference type="OMA" id="DITICHF"/>
    <dbReference type="OrthoDB" id="2142683at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034224196" evidence="2">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="3">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083774.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21102" checksum="F2C60B4A31246136" modified="2022-01-19" version="1">MAKARLWTLCKTVVIVFAFVGVESRCPASWIERQTSCYKTDDEQRTWENGEAYCNQLGAELVVIETAQENEFIRELLNDQSKDFAWLGCNDRATERTWVCYSEATVGMPFENWAPSQPNNAAGDDCVSISKSGKWSDSKCSADFVYVICEADSADWEDLHMDVTSSSAAVVSMSCSVVGADGRLHHLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSX5</accession>
    <name>A0A8B7XSX5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein NLRC5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083312.1">
        <property type="nucleotide sequence ID" value="XM_022227620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSX5"/>
    <dbReference type="GeneID" id="110975278"/>
    <dbReference type="KEGG" id="aplc:110975278"/>
    <dbReference type="OMA" id="ISHFEAN"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="75"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="224"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083312.1"/>
        </source>
    </evidence>
    <sequence length="441" mass="49504" checksum="B6A2C477F3BA3544" modified="2022-01-19" version="1">MGGLIGRAILGLQQIMTPLEQQTQEQAVGRPEQQDQTTGGEQILGVRRPDNQDQTTGKLDDMTLHSISAQIHAGEWRKLATRLGFSPAEISHFEANHSTDVVGQILDMLVSWRNKQADNVDQREALSKALREVRNTHLADELSEHCSSDVPSQDAVKHCAKEMKWFYSKRGGFVKMKPWLRDKKHIAVMYTKLKLLTGEEFTERELESYEDILLLQTREGDPIPIAVLSGLAGSGKTTLFDKIAYDWAVGSGQVLQKYKLVFLLKMFALEQGSDLTDAVFDQLLAEDTKMEQNALWSYIKTNPHQVLLLLDGFDELMTTSLDKSSFGSILKILNGKLCRGCTVLVSTRPSHFHRLVTEELVEEPFAHVRVMGFSGENIREYVKKFYSDKPDKAEGLIERIKTSNLLSTLAASPMLLLLMCLLWSDDSTLPETNVAPVPQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTW8</accession>
    <name>A0A8B7XTW8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase F1 subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110975341</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083449.1">
        <property type="nucleotide sequence ID" value="XM_022227757.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083450.1">
        <property type="nucleotide sequence ID" value="XM_022227758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTW8"/>
    <dbReference type="GeneID" id="110975341"/>
    <dbReference type="KEGG" id="aplc:110975341"/>
    <dbReference type="OMA" id="WIAPSAM"/>
    <dbReference type="OrthoDB" id="10045676at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000007">
        <property type="entry name" value="ATPase inhibitor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48417:SF1">
        <property type="entry name" value="ATP SYNTHASE F1 SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022083449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022083450.1"/>
        </source>
    </evidence>
    <sequence length="119" mass="13216" checksum="47D49D94869913FC" modified="2022-01-19" version="1">MSLMRVSAIRLFRPIAAVCQVQRGYSNDHGVMGSGSGKGGGTGGSIRDAGGAFGKMEAAHEEQYFRQLQAEQLKALKKHHDEEIEAHEREINRHAEEIKRLKKRRREIDSHTGSSSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUU4</accession>
    <name>A0A8B7XUU4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110976014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084619.1">
        <property type="nucleotide sequence ID" value="XM_022228927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUU4"/>
    <dbReference type="GeneID" id="110976014"/>
    <dbReference type="KEGG" id="aplc:110976014"/>
    <dbReference type="CTD" id="9352"/>
    <dbReference type="OMA" id="PIFEMFP"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="121"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084619.1"/>
        </source>
    </evidence>
    <sequence length="294" mass="33137" checksum="40ADB0B69F2D4C0E" modified="2022-01-19" version="1">MASNAKPMPSNFKVVHNDQLEAELTNAGKKLVVVDFTAKWCGPCQRFAPEFEKLPVQYPDAVFVKCDVDENPQSSSKNGIRAMPTFVFFRSNSKIDELRGAKLADLKRKVEKWLQPSSGGDQEDKTKHYMNLVSLIDKSSVECLNQSNEHDFEACLTNDDRYLESDCDEQLIITVGFIQNVKLHSLKITGPEGFVPKTVKIFINQIKTLDFDKAEKSEAVQVLDLTKDDVLEDVVIPLRFVKFQNVSSVTLFVRDNQGMEDTTRIRHLAFIGLPISTTNMGEFKRISGKSGESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUY7</accession>
    <name>A0A8B7XUY7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110975561</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083835.1">
        <property type="nucleotide sequence ID" value="XM_022228143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUY7"/>
    <dbReference type="GeneID" id="110975561"/>
    <dbReference type="KEGG" id="aplc:110975561"/>
    <dbReference type="OMA" id="LARCKHN"/>
    <dbReference type="OrthoDB" id="10554731at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034350688" evidence="1">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022083835.1"/>
        </source>
    </evidence>
    <sequence length="106" mass="11899" checksum="D400CD9B416BF6AE" modified="2022-01-19" version="1">MARFVLLACLITVLVVSLEAQCPPGGTRCNTHVGGAFDRKGLLENLLERKDLDLAEMDDKSLKRALDLLEHERNRAGAVPKPAEHEREATIKDEELRELLLKILQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV24</accession>
    <name>A0A8B7XV24_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110976057</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084708.1">
        <property type="nucleotide sequence ID" value="XM_022229016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XV24"/>
    <dbReference type="GeneID" id="110976057"/>
    <dbReference type="KEGG" id="aplc:110976057"/>
    <dbReference type="OMA" id="ITDEMMA"/>
    <dbReference type="OrthoDB" id="10064299at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034700102" evidence="2">
        <location>
            <begin position="22"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022084708.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55748" checksum="A36C04A9D5C9CB4B" modified="2022-01-19" version="1">MTRWALLVVLLASLVLASTNAAPVQDSNKETPEVSAPTKATDTVEAEAEPKEGKIEKEESPEETKDDAEEKEKTEVVEGSGLDTDEKDETVQPNEEVTNFKEIETDENSHITHGNNELSYPGSFGNDFDDYRLSEEDAMELLRELADPTQVALFIMQTDDVTGFLRSVQMLQDQGFISDEYAFLLKEAVSQELEQLLMMQDGEMYGDPLGLQNVEQTENDYVDEMLNRPVPYFPEDYFDNTLPYQQDDFYPEIENYDLFRQPYSEETMALAQIANIIADQIESGEMSTAKGERIIDILSQLLPEGFWQDDDITDEMMADLGEAFANLYPEIPVGEQYQTFQTEDDEPLPGGERHTEEEVMVDEEGHPVAEVVKVQEEQELGTDGEEADEEEGNPDEELEKELLGMEPETSEEVEKALQDVEKLMTTDEETKGKEEEETDEEIGDSGWKDLVLLLDEGKISDELLKELGLTREDLMELTERQLAMNGDEVASKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV87</accession>
    <name>A0A8B7XV87_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC110975731</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022084157.1">
        <property type="nucleotide sequence ID" value="XM_022228465.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084158.1">
        <property type="nucleotide sequence ID" value="XM_022228466.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084159.1">
        <property type="nucleotide sequence ID" value="XM_022228467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XV87"/>
    <dbReference type="GeneID" id="110975731"/>
    <dbReference type="KEGG" id="aplc:110975731"/>
    <dbReference type="CTD" id="23192"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="45"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022084157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022084158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022084159.1"/>
        </source>
    </evidence>
    <sequence length="470" mass="53341" checksum="2BE01FF1CAD0EF62" modified="2022-01-19" version="1">MMDVALGNVACVTYESGMVSIEDFPHDKGPVWIMGRKYDINRHRQEAKRDVHSRLWMTYRRGFANIGGTGPTTDQGWGCMLRCGQMMLAQALICRHLGRDWRWNPTEPEESYTRILKMFLDRKDCPYSIQQIAQMGVGEGKSVGMWFGPNTVAQVLRKLVAFDSWSNMAVHVALDNTVVQEDIRKVCCGSRETQCGHASSTQPPSNKSVHETKSDARAESAFTRAWRPVLIFIPLRLGLNEINAVYVKRLKRCFTLRQSLGVIGGKPNHAHYFIGFVGDELIYLDPHTTQPALTTDKWGFLQDEGYHCDHACRMNIHNLDPSIALGYYCHDEADFEAWCKDIQQVIKEQDLSPMFELTEERPSHWPPFDPGQSSMETSFGVLYTTAGVKARDKSVLHVSSKQWNSTSRATGTNDRGSCCTYHNARILTDVYQHRHEGSLHTVASVSLMDKSSRSRIDHENSFINLLVTCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVV8</accession>
    <name>A0A8B7XVV8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kinetochore protein Nuf2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110976218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084994.1">
        <property type="nucleotide sequence ID" value="XM_022229302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVV8"/>
    <dbReference type="GeneID" id="110976218"/>
    <dbReference type="KEGG" id="aplc:110976218"/>
    <dbReference type="CTD" id="83540"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48441">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48441:SF1">
        <property type="entry name" value="NT-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="145"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022084994.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="49779" checksum="7CCD4576000A1ACC" modified="2022-01-19" version="1">MTSTFRFPILPIDELINWLRVELQLDDLNITEEDFKNPQPHRVQMIYRMILETVMGIRQEKIIQPHFEAVQQLSYPEFFEENISLVNLAMGMTRFMAACDVNDFKLKDLSSPKPKRTVRMISAIINFCRFKIARMETYERIQADVDSVKEQHNHYLRRIDELKTQINTIKANRAEKEVLIKEMSAKVDELGSTMNGYKQEQASLQQGIHQVKTGCSEKAAKLEQLKVNTLNAREACDKLRPQIIQSPERIKTDMARMHNAIAAGKKATEEKGQRLQELSSQKENMLKWCEAAETGVKLLTAINAELDKQNEGVPKSNALNAPMRIICRDGTSQLVSVLYLMNKIKVCVFSYEPFPSCSNLASCSQKQQKKMDHIAAIEEKKAQVRQQFAEAKSGHADKMNTARGSYSTLLHSIDSYHKDLAETFEAANPIKILSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW12</accession>
    <name>A0A8B7XW12_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Neural retina-specific leucine zipper protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110975670</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds to the rhodopsin promoter in a sequence-specific manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with FIZ1; this interaction represses transactivation. Interacts (via the leucine-zipper domain) with CRX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084036.1">
        <property type="nucleotide sequence ID" value="XM_022228344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XW12"/>
    <dbReference type="GeneID" id="110975670"/>
    <dbReference type="KEGG" id="aplc:110975670"/>
    <dbReference type="OMA" id="DELYWMS"/>
    <dbReference type="OrthoDB" id="5974330at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14718">
        <property type="entry name" value="bZIP_Maf_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000071">
        <property type="entry name" value="Neural retina-specific leucine zipper protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024874">
        <property type="entry name" value="Transcription_factor_Maf_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129:SF44">
        <property type="entry name" value="TRAFFIC JAM, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10129">
        <property type="entry name" value="TRANSCRIPTION FACTOR MAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BZIP" evidence="17">
        <location>
            <begin position="241"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022084036.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="36173" checksum="EAEB86C96AB5A624" modified="2022-01-19" version="1">MASTDETSCDFETDAALAMEYIQDFDLLPLALEHIEVKREDQANSLGTSCLIQGQGAGSAAAVTSSGGTGAVAAKRRSPPTSLPNLGTGSLTPLVESPCVDVPPSPDDLGLIPSPVDMEYKPNLDELYWMSSIQSLTTINNLQLMSPVYSTGDTGDITTATRPSDLDCDKYSDCSGTEPRDEDEESISSAADSDSTDPGAPAVTKPTKDIFSLYRDDELVRLTVRELNRQLRGYKKEDVVKLKQKRRTLKNRGYAQCCRTKRLKQRLDLEHSQLFLHTEVTRLKKELERVQNERDKYRKELELVKSARRLRADSLPSSPESPEYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXQ5</accession>
    <name>A0A8B7XXQ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Atrial natriuretic peptide receptor 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110976242</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085037.1">
        <property type="nucleotide sequence ID" value="XM_022229345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXQ5"/>
    <dbReference type="GeneID" id="110976242"/>
    <dbReference type="KEGG" id="aplc:110976242"/>
    <dbReference type="OMA" id="EHEWENG"/>
    <dbReference type="OrthoDB" id="302535at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06352">
        <property type="entry name" value="PBP1_NPR_GC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052612">
        <property type="entry name" value="ANP_Clearance_Receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001170">
        <property type="entry name" value="ANPR/GUC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755">
        <property type="entry name" value="NATRIURETIC PEPTIDE RECEPTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44755:SF8">
        <property type="entry name" value="RECEPTOR LIGAND BINDING REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00255">
        <property type="entry name" value="NATPEPTIDER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034820171" evidence="8">
        <location>
            <begin position="19"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Receptor ligand binding region" evidence="9">
        <location>
            <begin position="60"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022085037.1"/>
        </source>
    </evidence>
    <sequence length="400" mass="45042" checksum="35B827FC327498E2" modified="2022-01-19" version="1">MSAALIYTFSLFLVVVRATVDVKVGMLHYSPHHDTFIGTFYFFPASQIAFETVAKRLETGQYQNFNMSYISTDECCTRPVRSSGALAASMYYDHGVDAFLGPAKSGEMTAVADMAAYWNLPVITAAESSFHLADKARFATLTRTFPATTSVSKYLASIFQQQSCVVLRGFERPRFFEHSIPPSITAALQAAGVTVIEVFADNYNTLDQALREAASWSNVIFICTSPVRDIMVHAYRLGYKADSHTFLYWYPVEKESWQTSSQFQNLNEEETEAMKALVVLHPELPKPDEAYRQFQSELRERQRALYGKTQIEDNFLAATLHDTILMYADVINEIVAEGSDVRDGRAVTKKMWNRTFEGVTGTFKISNNGDRLLVNEMLQMTDDNTGNFNVAFTHDEAADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZ10</accession>
    <name>A0A8B7XZ10_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside diphosphate-linked moiety X motif 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17" type="primary">LOC110976834</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May contribute to the regulation of cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086136.1">
        <property type="nucleotide sequence ID" value="XM_022230444.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086137.1">
        <property type="nucleotide sequence ID" value="XM_022230445.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086138.1">
        <property type="nucleotide sequence ID" value="XM_022230446.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086139.1">
        <property type="nucleotide sequence ID" value="XM_022230447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZ10"/>
    <dbReference type="GeneID" id="110976834"/>
    <dbReference type="KEGG" id="aplc:110976834"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04670">
        <property type="entry name" value="NUDIX_ASFGF2_Nudt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000027">
        <property type="entry name" value="nucleoside diphosphate-linked moiety X motif 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003293">
        <property type="entry name" value="Nudix_hydrolase6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040618">
        <property type="entry name" value="Pre-Nudix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994:SF46">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE-LINKED MOIETY X MOTIF 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13994">
        <property type="entry name" value="NUDIX HYDROLASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18290">
        <property type="entry name" value="Nudix_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01356">
        <property type="entry name" value="GFGPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="12">
        <location>
            <begin position="143"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022086136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022086137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022086138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022086139.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="35308" checksum="C0A935F2CAEBCD10" modified="2022-01-19" version="1">MLFHSILRTAASRRLCPIFKNPTEWCNNYASSRHVCMSDAASLLNIGKEDRFNCIHVNVGDDRHLKSCKSEGSAAFTHSLSESLSQWRLESRTAVWLKFPKEQCHLIPLAAKQGFELHHAKDGHVVMSRWLRQDASRLPRYATHQVGVAGFVLNEETEEVLMIQDKHRLVRWKFPGGLSNPGEDIQDTAIREVNEETGLQTEFKSILSFRQQHNHPGAFGCSDIYVVCRLAPLTYDIQICPTELEDARWMKVADILASEEDHSPLTVRMSNLVMCGLRDGFDRIDIAIDELPSVYNTTYKLFHRPYIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1A7</accession>
    <name>A0A8B7Y1A7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Olfactory receptor 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110976616</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085751.1">
        <property type="nucleotide sequence ID" value="XM_022230059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1A7"/>
    <dbReference type="GeneID" id="110976616"/>
    <dbReference type="KEGG" id="aplc:110976616"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="49"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022085751.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42123" checksum="401FFC4F01561543" modified="2022-01-19" version="1">MGDEDIMPEECDKYWNISEENVSKWLFTQGDGVFITIIIPIICGFGVITNLGFLCVVFCVPKMRSGIYVYLSQLAVADSLYLSLTSAYFIWSYAASPVFHHFPFSNSGGCMSFFTVRFTSIVASVALITMALYDLYLTLCHPLKHRVVHSWCRTCRITVGCWLVGLLGGVSLALDSSTAQKNCLQWPHDDMYQELPTVVIACTPAHPNVVYYSGLLFTVPWLFVIFAVVYMCIRISRALRERKAINKRRQVLQNQRQMTRMIVSNIAICIMCQIPALIRNVSVFVASLTGVPKPGAAWRGSLWLSVVFQLLNSAVNPLLYGAINAQCRAAFLRALSCRKRKPEDKDADDSKVKIESACNTLPVHQINQDTNMTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2C0</accession>
    <name>A0A8B7Y2C0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087319.1">
        <property type="nucleotide sequence ID" value="XM_022231627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2C0"/>
    <dbReference type="GeneID" id="110977459"/>
    <dbReference type="KEGG" id="aplc:110977459"/>
    <dbReference type="OMA" id="KIRGQQM"/>
    <dbReference type="OrthoDB" id="10368295at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034208378" evidence="1">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087319.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18582" checksum="27ECB0C1155E34F6" modified="2022-01-19" version="1">MRIELLLFLTLACKVESNWDITHSDPAEANMGFTTFNMKCNDDETVCHHSFTMHVYGRLFLISTAYMKNPFKFQLNITEGGNNWKIHFAQGDQSEEYRWCDNAFSRSSIIRYATRFVLCVGNSFTGISVPDDCPKPVTLVDLDNHNFDEKIRGQQMLYCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4G7</accession>
    <name>A0A8B7Y4G7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087220.1">
        <property type="nucleotide sequence ID" value="XM_022231528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4G7"/>
    <dbReference type="GeneID" id="110977418"/>
    <dbReference type="KEGG" id="aplc:110977418"/>
    <dbReference type="OMA" id="CGEVSFN"/>
    <dbReference type="OrthoDB" id="6142414at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000801">
        <property type="term" value="C:central element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034609">
        <property type="entry name" value="Syce2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28398">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28398:SF1">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX CENTRAL ELEMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087220.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="20502" checksum="C4DFCEA28EDD6992" modified="2022-01-19" version="1">METMESYSSAAAADMTSLDLPQQGTQPVVENQGDFDPDRADFLEPSIPTESACGEVSFNFTVPSQGFQPSTKQIRSTSSSLTREILNQRTQQLIDDINAKRKRDTSLLADFKKAIEVQASNSYDNLEQAMFQMYEGNGKVIQEKLQELFATLDRISKLEMELEQFKTSLGALYSEIQGPAARPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4N7</accession>
    <name>A0A8B7Y4N7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 24">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="6 24">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21 24">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC110977569</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22 24">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="6 24"/>
    <dbReference type="RefSeq" id="XP_022087502.1">
        <property type="nucleotide sequence ID" value="XM_022231810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4N7"/>
    <dbReference type="GeneID" id="110977569"/>
    <dbReference type="KEGG" id="aplc:110977569"/>
    <dbReference type="CTD" id="3735"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000029">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="26">
        <location>
            <begin position="271"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00059215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022087502.1"/>
        </source>
    </evidence>
    <sequence length="616" mass="70329" checksum="959F5792D5DA55FB" modified="2022-01-19" version="1">MWRLSLKYGTFLCQSLARPRLPNQVLNFGDVWIWKKVAVIRCSCYSSGTGDDSELKRRAKAAKKAEEKEEKARAAAEKQAQDGAKASAKKPTVDEETLDPREYFKIRSQMIKNLKEANDTPYPHKFLVTISLTEFIEKYNHLEAGEILNGEVHSISGRVHAKRVSGAKLIFYDLRAEGKKLQVMSNASKFSSEEEFFKANDKIRRGDIIGVRGNPGKTKKGELSIVPSEMSLLSPCLHMLPHLHFGLKDKETRYRQRYLDLIMNEYVQQKFVVRAKIIAYVRKFLDDFGFLEVETPMMNMIAGGATAKPFVTHHNELNMDLFMRVAPELYHKMLVVGGIQRVYEIGRQFRNEGIDLTHNPEFTTCEFYMAYADYNDLMEITEAMLSGMVKCITGGSLKVTYHPDGPEGEAKEIDFTPPFRRIHMIEDLKKLLQVDFPPMDQLDTPEAQKFFDDLCVKKGVECSSPRTTARLLDKLVGEFLETQCINPTFIIDHPEIMSPLSKWHRTKKGLTERFELFVMQKEICNAYTELNDPLVQRERFALQAKDKAAGDEEAQMIDENFCTALEYGLPPTGGWGMGIDRLTMFLTDSNNIKEVLFFPAMKPEDNKPTDDQPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y549</accession>
    <name>A0A8B7Y549_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Homeobox protein MSH-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110977673</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Msh homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087667.1">
        <property type="nucleotide sequence ID" value="XM_022231975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y549"/>
    <dbReference type="GeneID" id="110977673"/>
    <dbReference type="KEGG" id="aplc:110977673"/>
    <dbReference type="OMA" id="GGYENYD"/>
    <dbReference type="OrthoDB" id="1867783at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050674">
        <property type="entry name" value="Msh_Homeobox_Regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338">
        <property type="entry name" value="HOMEOBOX PROTEIN MSX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24338:SF0">
        <property type="entry name" value="MUSCLE SEGMENTATION HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="211"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="213"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022087667.1"/>
        </source>
    </evidence>
    <sequence length="332" mass="36165" checksum="5A9C2651645FF908" modified="2022-01-19" version="1">MRRQSMALLSSGYPAAFQGGLPCSGLFSLGVPGASTPLPYPNLSLMRVPPHLPMGFAVANLSAAYLQSPQSRSDSEFSAVLSKHHQQHHQYPQQSQLNPTLAQTTNSSPKRKGVTNFSIAGILGRDEDAKATEKCTETSPPKTARAPEESSANDPELESKVHVKTECLSSPKGDEEETDNPLTRFSWLQCTRYKPPRLPRAKRKDGAKKRKLGRNPRVPFSPAQVTTLEQKFRCTHYLSSIDVAELSAALNLSENRVKIWFQNRRARERRDKEAASKDAPSSPNGTLMKPCSSPAPATGPSSLITMGHPALSPSPVDGCASAFTPLSYPFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y790</accession>
    <name>A0A8B7Y790_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110978405 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110978405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089084.1">
        <property type="nucleotide sequence ID" value="XM_022233392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y790"/>
    <dbReference type="GeneID" id="110978405"/>
    <dbReference type="KEGG" id="aplc:110978405"/>
    <dbReference type="OMA" id="TNTHWWI"/>
    <dbReference type="OrthoDB" id="6127264at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051277">
        <property type="entry name" value="SEZ6_CSMD_C4BPB_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45656:SF4">
        <property type="entry name" value="PROTEIN CBR-CLEC-78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0768">Sushi</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034350028" evidence="7">
        <location>
            <begin position="25"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="25"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="85"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="153"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="8">
        <location>
            <begin position="286"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="420"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="9">
        <location>
            <begin position="481"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="422"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022089084.1"/>
        </source>
    </evidence>
    <sequence length="931" mass="101520" checksum="41F9EEFD3D162E1D" modified="2022-01-19" version="1">MDSYRNRQVLPLFVFFVLITASQAIPCNSTESLSNVACHTNQTNGLEYVVCECLPGYELQGPTSVAVCLETGQGWGETMPNCTAIRCLAPDSPAGSIVTPAHDSYITGGTITYTCLEGFSGDEDPTRRCLPDGTWSETNFRCLPCSATGLLYDSQSCFIPVENGVSWSEAQSSCNANGWSLAKVENSEEQTFLFSQIDSREHWIGGKEATNWIWESSQMPIEYFTLADGEQNIVDNEGCLYLSALPDRSDLQWNDINCGSSVNPRMMYSICQFDLPCPSLPNFGAYDKYCIEFSQVSRTWYGARDYCKSNNRWLVEVTDQGLQDFLRNALMSSYGGTNTHWWIGGTVSTSRVWRWTDGELVKDTFWKDDQPGCDPSFPSGQDVKCIEMNFNLQQMDNWQCISCENQQRYYICRSDARNITTCGDPGVPLHGTRSELEYGTFNTSDIIQFMCEEGYKLTGSESRECLANGTWSGLPTTCNIITCEEPTPTANGNVTVLSAEYRGLAILSCAEGYEIDGEALIVCMSNGLWTSPNSTCVEVRVTSPEYLTTSSEVTAVVSTSKAASTTTQPTSYSSATSVELTTLQLTSRPDTGVSTSITDHSGGTTPETSNPTTQGVATVPTLSTGKPISTSYATTPSAHLTPVESTAPHSTTAPPQATTRVKPLSTHHVTEVATTLPSISRTMSESLTTSEDAITIVSTDAGSPDDEATLGSTELLIIITVSSILGLILLIFLLITICWCCSCRKDKKHLERYKASVALANKPANLETETVPPDVIGDLVVSAWPRSSFFDVRSGPPTVDNDYHGLGGDYAEPDYSTILPRASVRHESSSSAYQVPQFPAYARALFRPEMSRGRSLQQALVEEIELEKHVYQGAINGAQSESGDDEALESHSFGQAELFVVPSEEKSDALGYAKVELNRGGSHLSYPSHHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8X8</accession>
    <name>A0A8B7Y8X8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">trans-L-3-hydroxyproline dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>trans-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10320"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:39785"/>
            <dbReference type="ChEBI" id="CHEBI:57938"/>
            <dbReference type="EC" id="4.2.1.77"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline racemase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.77" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022088997.1">
        <property type="nucleotide sequence ID" value="XM_022233305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8X8"/>
    <dbReference type="GeneID" id="110978363"/>
    <dbReference type="KEGG" id="aplc:110978363"/>
    <dbReference type="CTD" id="112849"/>
    <dbReference type="OMA" id="SHVLWTG"/>
    <dbReference type="OrthoDB" id="6409228at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050346">
        <property type="term" value="F:trans-L-3-hydroxyproline dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.10:FF:000003">
        <property type="entry name" value="Proline racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008794">
        <property type="entry name" value="Pro_racemase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33442:SF1">
        <property type="entry name" value="TRANS-3-HYDROXY-L-PROLINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05544">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029792">
        <property type="entry name" value="Pro_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00028">
        <property type="entry name" value="Proline_Racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022088997.1"/>
        </source>
    </evidence>
    <sequence length="367" mass="39814" checksum="20E34EDEF3E1811D" modified="2022-01-19" version="1">MPHAYHVGCLTAVASNMSSAVEKSLFGNIKLRTVEMHTAGEPFRIVVSGYPKFEGETILEKRRFAREKLDHLRKLLMFEPRGHHDMYGAILVEPDLPGADLAVLFTHNEGYSTMCGHGVIALGRFAVDHGFVKPQQPETEVAVQCPCGLVRAFVEYNEERKKTGQVRFNSVPAFVFALDTEVQVEGYGSLKVDIAYGGAFYALISAHEFGLDVRRSCVKDIVNAATAVASAIKAKVQIKHPDSEGSDLDFLYGVIVTDGQDAWSDQPTANICVFADAAVDRSPTGSGVTARVALQHAKGQIALQQTRSFESGLCGTVFTGKAIKMTKCGSVDAVIVEVSGRAHYTGEATYTIDEDDPVGSGFLLRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y941</accession>
    <name>A0A8B7Y941_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-galactosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC110977972</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyses the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022088238.1">
        <property type="nucleotide sequence ID" value="XM_022232546.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088246.1">
        <property type="nucleotide sequence ID" value="XM_022232554.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088256.1">
        <property type="nucleotide sequence ID" value="XM_022232564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y941"/>
    <dbReference type="GeneID" id="110977972"/>
    <dbReference type="KEGG" id="aplc:110977972"/>
    <dbReference type="OMA" id="NITEPCP"/>
    <dbReference type="OrthoDB" id="10038994at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008489">
        <property type="term" value="F:UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF38">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="153"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="270"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022088238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022088246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022088256.1"/>
        </source>
    </evidence>
    <sequence length="404" mass="46861" checksum="7FE1123BEA5396CB" modified="2022-01-19" version="1">MTGIYVALVVCLVLGTALQFVVLPLFYFHRGVNGDWYQFEEIYIPTESNWIGSAGGIISTVLPRNGSLTDRIRYHRLSECPDHSNIPNLNKLTFYELDDSVTMDQAEKIVFGAEALERARRATALADSAIPKLIDKKIWFKTSGRRIMEANLAELEMKIGNYTFIPGGHWRPNHCIPKGKVAIIIPFRNRFHHLSILLRYLVPMLQRQLLEFGIFTVNQENELSFNRATLMNVGFMESLNMSHWDCFVFHDVDHVPLSDLNYYGCSNMPRHFITGDNVWNYTLLYENLFGGVTGFPGSDIRKMNGFPNVYWGWGGEDDEILLRARKANLKIWRRPRGRSRFIGFYKVIEHHHHSAPKIPERYDLLKNYSTRMNYDGLSNLRYPPPRLEIHPLYVNISVDIFRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBW1</accession>
    <name>A0A8B7YBW1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Protein ELYS-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110978962</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090036.1">
        <property type="nucleotide sequence ID" value="XM_022234344.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090037.1">
        <property type="nucleotide sequence ID" value="XM_022234345.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978962"/>
    <dbReference type="KEGG" id="aplc:110978962"/>
    <dbReference type="CTD" id="25909"/>
    <dbReference type="OMA" id="KWNHDCL"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032040">
        <property type="entry name" value="ELYS-bb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052620">
        <property type="entry name" value="ELYS/MEL-28_NucAsmblyFactor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583">
        <property type="entry name" value="ELYS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21583:SF8">
        <property type="entry name" value="PROTEIN ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16687">
        <property type="entry name" value="ELYS-bb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS beta-propeller" evidence="5">
        <location>
            <begin position="44"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="ELYS-like" evidence="4">
        <location>
            <begin position="759"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1222"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1362"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1509"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1693"/>
            <end position="1960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1222"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1255"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1388"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1411"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1509"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1559"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1705"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1723"/>
            <end position="1734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1735"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1780"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1820"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1859"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1900"/>
            <end position="1909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022090036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022090037.1"/>
        </source>
    </evidence>
    <sequence length="1960" mass="216161" checksum="806009872CB56B53" modified="2022-01-19" version="1">MAQPMNAHWTSSVQPLCTPSLTALQGIVSTGRPCLFGGCASGGHWSWLARNSVLEVVDNVTGNRRSAFQFGRAIGANDVQITCIKEYRYKDATSLIVGLKTGSSDGMLCIFDPRTSKVVLAVDIPQGVTSVEPVTSEGGLKAPNFALGDHLRLFFGIIAVGTEGGHTYLLDVRVDDGDCCDEVTARGSKVISPRSTDVGTIREKATRKGEHVCLHLDEDSHSFRSFNFRKPDHSVLKSFYPSEVSVTSLSYLKQTGSLVIGFSFGCFQLWELSVPVLEYSSTISTQPSPVTHFAYQEPEDDPENFGYLWVGRGPQATDVDQDVPTNLHLFQLMYTKKEVHDNYGHLYKELISCEARFLHSLTVDPFNVVNQASEGSRIISCFPLAREIAPGAIKQEDSTCDEEGDHLDIGLAVFVWEARSDPADGPETSSCFLGLFDLNRWYHAQMPKAVRMLPGKQGCSFFAFYSLDSILQAASPDFLTDLHVNPASVVPYVSSHVPAPELHFQPSALSFDVVCLMEAGLVSAKFLGQQKQVLADLCQQGPPALREPKFFFTRCWLAGLLPKKYTSDQGPANATAQDQREALLTVAVEHNMVNFVIQCINSWTHGDFPSGCNLRTILDWAWGLVTSIKQSIDHICVPFYNGEGTHVDDRNRRLLDQNAVRLGHMITIIQSLLDQSATTTEQGLKDLETKCNVVTLIHQHLKAVIWFVRSGLLPECLDERDLLEGQFYYPAASLRKIYARRRLQLQKMCLNTSSESNILMIDGLVAEIGSKLTALWDRKEEGGTGLYPPPSFHALLDMYLVDTVPVVTKHCIVGYFLMDVLHVSPLPSTQKEELGRRIDKFFQSFSLPLGVIKLLHGFSLLDRREFDNAIDMLLDPTTTLELAPWQHRHIIKALLYQGESKKALQYVRTARPPLTTRDDVKLYLTVLLANGLTAEAFHFQRQYRDEANTEELLTHLILGSQQTKTVDQLLKLPFDDEEEATLERYLQESTEPNSQELLVMHFLQRARYVEAVRLNEKLKQEGLMADMDPAARERATARNAIVESYARLLPPVQRRLAFGPETSTKRTTLIRREISRPKPLSAVINPAKTSKVLSNAMLINAVLERIAEARVQTKQEETPIKMSVAEELEDDLPSMEPFVGTPITPRAKSRFGEMSSVIYPEVTGRDISPWKRQPSPTKTRPYLQTLAGDTSIRVTEKFASISKAPANYTSASALSLLQTPSVTRTPSKVRNDGTPSTRSIPSILKVRSTSQRITTEVREDKSKKNVSRTKFEIDLPTPPSLTKSAYAKPSEHQSDKPPGLPKRISFADDTKARTPSPVAVKIEPSPMDTEASFDTPPPVESPSVYPSLNDLMSQPSVQASLTLAQPSPPLGKPSPLSGQASPPMGQASPPLEQSSTSPEQSTTSDQPTPPGLQSLTQQSADFPNAATTQGGFDVSLDVSPSVRTSPPTEKFEITSGTGMLVDDEITFNFGTLKNLEGEMDMEDLATTEEESPEKSQYQMSFAADFNVEDEDVGEMADEQEDLEDAEEEQEDEELRPLTKSDLIPSPRPPLRRMAPDTATPRSIPTTSHFTPSLLLLRQPSPSPPLTQKEEDDFVTPQQTPEKPDAGMEFPSPSPPLPTTEEGRESLSNFSEDAGEDSEEKLGAESVEIQTSPMDLIASTEHQEMSVQTTPGLALRQGGATPVRVPFEASLVSSLLQQEPMTPPTSGEETAAESSSSEQVASQDEGQTVPGTQPSEEMDVAMETLEAEEVQIKKEPVQKKRGRKSTQSTPALSFIFSPPHTRSRTGTRRHTQKIIQEVMTPLARPMTQTPLLPTVGPTPSLDLTSSSIGGSAQSRGATPSSAPGTTRRGRRSHTPKLDTSETTGSTRVTRRSVTPVVKSEQKAKSAELGGPVTRSRRSLVTPHQSPTNSPVALLSPLEEDMDTTQTTKPSRPKRVVRIAPHSMTLRTPQERKTRSRNIKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFX1</accession>
    <name>A0A8B7YFX1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette sub-family A member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110979744</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091487.1">
        <property type="nucleotide sequence ID" value="XM_022235795.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979744"/>
    <dbReference type="KEGG" id="aplc:110979744"/>
    <dbReference type="OMA" id="QIMGICP"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000327">
        <property type="entry name" value="ATP-binding cassette sub-family A member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF250">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="835"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="929"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="989"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="145"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1070"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="465"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022091487.1"/>
        </source>
    </evidence>
    <sequence length="1391" mass="154285" checksum="F665158452320E52" modified="2022-01-19" version="1">MPYYFIMLFYQRMTLPGKIASCLLSNTAMGLGTQLIAIFEGTGEGVQWSNVHRPVSVDDDFTVLHVMLMMVADIIIYGIFTWYVEAVFPGEYGVPQGWNFFLKPSYWCGTPVVTEAINTDSFPMEVRSANEGFFEEEPSGMQAGLQIRNLTKIFSKNKAAVNGISLNMYKGQITVLLGHNGAGKTTTMSMLTGFIPPSAGTAFLNGCSIRGNLEGVRSSLGLCPQHDVLFDDLTVEEHLYFFGKLKGLTSSEVKKESDHYIEATGLQDKRKQYAKSLSGGMRRKLSVAIALIADSKVVMLDEPTSGMDPDARRSTWDLLETHKADRTILLTTHHMDEADLLGDRIAIMDHGELQCCGTSLFLKKKYGVGYHMVMVKSPQCDVAKVSNLIHSYIPSAALESDVGAELSFILPNEASDKFEGLFTELEESKDQLGISSYGASLTTLEEVFIKVGENSDSTLRDRLHQAPETDNHHQETSTLLPLKAPNGLVPNGKVHSNGTVPPSPSSPKRPRYGSMDNLNVHQGSLLGDSTLVDMSRGSSSDGNLSDKFSSTSKLPLTERRNKGLQLYAQQFWAMLVKHVLHSMRNFILAAVQLAVPLLNTSVAVVLILIAPQLEASPPLVISAKPYQNSIAQFSKGQNLSYPVTESLGNMYTRHFDGTATRVIDIDAITPLPHSMREYLVSQGETSISAFNSRNLVSATFEYFDNRPVIIGNISLGNISLLVGTALYNNQPYHASPLALNAINNAYLMHYLTEDHRVTVINEPLPPTVQEQFAQESDAFGMGSMIAFVMMFGMAFLASSFGVFLIMESSTKAKHLQIVSGVHATTFWLAKLLWDLINYMIPCCLIGILMLACRVESYALEGRVWDLYLLLFLHGWAIIPFSYLLSFSFKEPASGYVRILIINIALSMVMYFTFEVLSIPELGLKHIAEILDWVFMLMPLYSLGAALEAYYLHFSHIKICLSFPPFSQQYCDAQGISYEPEYLTWGGKGIGRYLVFLAIEGLVYMALVFLVDSSLFKKVAPPLRNACCRRKALVYSETHKVTKLEDDEDVAMEKSRISDTPLTKLCQTDTLLIRNLKKVYSLRGGQGLVAVDGISVGVPLGECFGLLGVNGAGKTTTFKMLTGDESVTSGTAFLDGYSIKSDIKLVQQRMGYCPQFDALIDQMTGRETLTMYGRLRGVPEAHISDEVNRLLKILTIEPHADKLTKTYSGGNKRKLSTAIALMGDPPIVFLDEPTTGMDPVARRLLWDTLSQIRASGKCIILTSHSMEECEALCTRLAIMVNGQFKCLGSVQHLKHRFGQGYTVLAKAKHGQNLNGFKRLMEEQFPGSQLKDEHQGMVHYHITNAQLTWAQIFGAMERAKSQYNIEDYSVSQTTLEQVFLNFARMQREDVLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YG87</accession>
    <name>A0A8B7YG87_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-microseminoprotein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-microseminoprotein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091410.1">
        <property type="nucleotide sequence ID" value="XM_022235718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YG87"/>
    <dbReference type="GeneID" id="110979694"/>
    <dbReference type="KEGG" id="aplc:110979694"/>
    <dbReference type="OMA" id="CICIEYK"/>
    <dbReference type="OrthoDB" id="9969981at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1900">
        <property type="entry name" value="Beta-microseminoprotein (PSP94) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008735">
        <property type="entry name" value="PSP94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05825">
        <property type="entry name" value="PSP94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034877043" evidence="5">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022091410.1"/>
        </source>
    </evidence>
    <sequence length="109" mass="12035" checksum="CF0A3243F0D25390" modified="2022-01-19" version="1">MGNFTPVLGLGLLFLVGIDASCEIIPDVECMVGGSIKENLPNRVSTTCTKCICIEYKQATAVQCCSIALVPTGYDKLRCEVKLNDRKCIYTVREIEPPHKPCRFSGYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHX1</accession>
    <name>A0A8B7YHX1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase</fullName>
            <shortName evidence="18">POMGnT1</shortName>
            <ecNumber evidence="18">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">LOC110980145</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1-&gt;2)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:13802"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="ChEBI" id="CHEBI:138067"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="18">The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with DAG1 (via O-linked mannose moiety). Interacts (via transmembrane domain) with FKTN; the interaction is direct and is required for normal location in Golgi membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Golgi apparatus membrane</location>
            <topology evidence="1 18">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="18">The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1-&gt;2)-O-alpha-D-mannosylprotein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyltransferase 13 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="18"/>
    <dbReference type="RefSeq" id="XP_022092212.1">
        <property type="nucleotide sequence ID" value="XM_022236520.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092213.1">
        <property type="nucleotide sequence ID" value="XM_022236521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHX1"/>
    <dbReference type="GeneID" id="110980145"/>
    <dbReference type="KEGG" id="aplc:110980145"/>
    <dbReference type="CTD" id="55624"/>
    <dbReference type="OMA" id="NYETEIH"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13937">
        <property type="entry name" value="PANDER_GnT-1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000038">
        <property type="entry name" value="protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004139">
        <property type="entry name" value="Glyco_trans_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039474">
        <property type="entry name" value="POMGNT1_PANDER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF1">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03071">
        <property type="entry name" value="GNT-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 18" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="15 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="ILEI/PANDER" evidence="19">
        <location>
            <begin position="124"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU368119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022092212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022092213.1"/>
        </source>
    </evidence>
    <sequence length="652" mass="75148" checksum="207E5AC81B824AFB" modified="2022-01-19" version="1">MDSWKPNPRAPPFIPRKHTHICSRGQFFRRLGSKFFQFLLVGVLMTTVIINILFIADTGRRLREVQSEGGAQDEALETNLLSNGNTFEKLSRQLEIEVLSSDKKAAISVGGTQVLEEEEKDVGRGIHVLVLNQATGSVMARRVFDTYVAHEDEAMVLFLNMVSDGRILIFTIKDEGTFQLKESARAFLKTLGSRDAEQMGWRDTWAFVTQKQKKHGHAFAEMHNKAVDMNHWGSPVILKTTINLVPVKESECNWPDTEANQRRRTFCDQLEGYGSLCSCDAPAPIDMSPEPLKNNTMLDVPVVVIASNRPNYLYRMLRSLLSAHGVNPKMINVFIDGYFEEPLKVTRLFDLKGIQHTPIGSKAGRISQHYKASLTATFSMYPSAKYAIILEEDLDVSEDIFSYFSQTSYLLERDDSLYCISAWNDLGYEHTVQDSTLLYRVETMPGLGWLLKRSLYKEELEPNWPTPEKVWDWDMWMRTPEVRKGRECIIPDISRTFHFGASGLNMNSHFQELYFKKHPYNTVPHVKLKNLEGMTREAYEDQMHRLISKAEVLDHSLNPCEEERFIPKLKGKSYVMYIQMYSDNDYETWLAVAKCFRIWDLDARGFHKASWRMFMKESPLFVVGFPASPYAKYKPIDVKPIYLKKQSKTKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YI37</accession>
    <name>A0A8B7YI37_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Testis-expressed protein 43-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110980493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092898.1">
        <property type="nucleotide sequence ID" value="XM_022237206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YI37"/>
    <dbReference type="GeneID" id="110980493"/>
    <dbReference type="KEGG" id="aplc:110980493"/>
    <dbReference type="OrthoDB" id="9972026at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027965">
        <property type="entry name" value="SPMIP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35247">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35247:SF1">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14983">
        <property type="entry name" value="SPMIP10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022092898.1"/>
        </source>
    </evidence>
    <sequence length="123" mass="14827" checksum="2E44456F600E3CAC" modified="2022-01-19" version="1">MAGRSELKPENVSIPEFSKLHPVIPRRYVPEWKNDMRNRELIMKFFYKIVNCDVSGIIPKGPHDESLFLDKRERMNEVEPRKRCESKRPVLERYHALRPEFHTSQSKYQSSLMFRRDDFTETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIR2</accession>
    <name>A0A8B7YIR2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110980188</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092295.1">
        <property type="nucleotide sequence ID" value="XM_022236603.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092296.1">
        <property type="nucleotide sequence ID" value="XM_022236604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIR2"/>
    <dbReference type="GeneID" id="110980188"/>
    <dbReference type="KEGG" id="aplc:110980188"/>
    <dbReference type="OMA" id="WICLMTI"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="10">
        <location>
            <begin position="62"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022092295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022092296.1"/>
        </source>
    </evidence>
    <sequence length="154" mass="16610" checksum="060EAAB3A4EF24B9" modified="2022-01-19" version="1">MELQTKDPNSNPPAVGEQVPGAYPIQQPWQPTAYPTQPQPQAAGQPPPALAGQTVVTAQPVGTTYVTMPMQVFSPEPRAMQCTNCGKNITTETRKANGAAVWVVVGWICLMTIWCCMWPFAFIPLCMPSLKDTIHSCPECKFILGKHSPGGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJP0</accession>
    <name>A0A8B7YJP0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sex-determining region Y protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Testis-determining factor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Transcription factor SOX-30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110979917</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Acts both as a transcriptional activator and a repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with CTNNB1, competitively inhibiting CTNNB1-TCF7L2/TCF4 interaction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRY family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091786.1">
        <property type="nucleotide sequence ID" value="XM_022236094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJP0"/>
    <dbReference type="GeneID" id="110979917"/>
    <dbReference type="KEGG" id="aplc:110979917"/>
    <dbReference type="OMA" id="RFLCDIN"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22033">
        <property type="entry name" value="HMG-box_SoxH_SOX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000027">
        <property type="entry name" value="Transcription factor SOX-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="22">
        <location>
            <begin position="507"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="20">
        <location>
            <begin position="507"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="320"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="619"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="800"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="863"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="829"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="880"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00054217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00063959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00070331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022091786.1"/>
        </source>
    </evidence>
    <sequence length="896" mass="95704" checksum="AE7E85B018B90F71" modified="2022-01-19" version="1">MISRDNVTASTFTSNRNGESPRSIITTGINSAPFAISNDAAQPSPQGHSTGSLNVGSKDYKKSDDHSEVQRVLVTQKSATSSASSNSNNLPTVIVGKSNTGSIAPISSGQGFYFLPAVKTAASTAAVCLNRPTTKTNPQSGTVTMTPSVATTTPSITCKIGDKVYRCFEIESNVTTPSNGSLLSKQELSVASRPPTSEGRSGKIFKLSNNEDRFAMVSKLPTTEKKSIIVSKQATTAEERSGTLFKLPTTEDGSKMSIKQPVGKESDNIMVSKLCHPEEPSITTSAEFVHQPRSTTDPVISIPSPSQQVTSLTNQQALRAPATNRLTSSANTSHAQPTEKTDEAPKELTSIPSSLNTETTADCSSVAGDAGTPEVEKNYTELTLYRPKNVKPPRPVEKAHSKAMPVYDAKMNDVVLSPFAGPLFQINENCSNAFGDGFKLAVVTNRATPIDCSPIAALTPSTSKPHATTPPKICSDDVGVVITDVDTMPAPNSDSLPRKRAHPTNHIKRPMNAFMVWARIHRARLAHQFPHANNADISIQLGQSWNALTQEQKQPFYDEAEKLRKLHRQEHPGWVYSPRPPKRRRDGFTLAPYNTNQACILPKCKLNPNATSHFTFASQPGCAAPKSESKGLPARSGAQPAPSNNTNIRLPAKDTRDKTGFTKQHYIIEPIGSPRPPAAIQTLQASSHPTIGGQVTVGQSARSAEARTHKTYAADGSALLHLVSGQAGHHVSGQGQGTTAVVSAGNVPIMVSPNVQFVRDTIQNITPSVGYTAPPQAGRVQTTIHDPVAIIDSDGGCLESASANVSSHAGSDSGSSTFHQDDDLDDDERSLNLHIPEDPGSTERRAVDVQLFQRFLCDINACAKQDNRKTPPPATHGDAPDDSGTDDNEELIDVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK00</accession>
    <name>A0A8B7YK00_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092952.1">
        <property type="nucleotide sequence ID" value="XM_022237260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK00"/>
    <dbReference type="GeneID" id="110980506"/>
    <dbReference type="KEGG" id="aplc:110980506"/>
    <dbReference type="OMA" id="RTFGSAC"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092952.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="23354" checksum="FF8378898377DF3C" modified="2022-01-19" version="1">MDGLLPSCRSVLLLGEGNFSFARSLSQKLNPDVRVIATSFEEEAAVWKRENGRENVEALRERGVTCLFGVDATKIHVSPPLEGQSFDGIIFNFPHVPGKANIAKNRDLLRRFFQSCVVKLTPVGQVLVTLCNGQGGTPADQPQREKQNSWQVVDMATYGDLILTDTVSFQAGEYQEYSATGYRCCSNGQQVKRVRSNLLAVLAFNTAYFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK51</accession>
    <name>A0A8B7YK51_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110979996</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022091926.1">
        <property type="nucleotide sequence ID" value="XM_022236234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK51"/>
    <dbReference type="GeneID" id="110979996"/>
    <dbReference type="KEGG" id="aplc:110979996"/>
    <dbReference type="OMA" id="CCINIPA"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000017">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="10">
        <location>
            <begin position="13"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="9">
        <location>
            <begin position="559"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="725"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="430"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="226"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="589"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022091926.1"/>
        </source>
    </evidence>
    <sequence length="853" mass="93139" checksum="43015F2B894F178E" modified="2022-01-19" version="1">MTACQLYRLFEDSTKKILVIDVRSSEQYKFSRIQNAQVINVPEEVIKPGTTVTVIAKGLSSDVKETWNMRGSVDCIVILDWNSTARDLTKGSTLASLKDALTKWDSTVTLKLEPLVLDGGYEAWLLRYPMLTTNPHVTRPPVDSSSSASLSLLDFDYPSLEDDQPNHSVKPKGPVVKPSISSGSNEQTTLPSNAMNSETISVITPTTVHSPKSIPTVNRSVKPKQLQENLSSPNKSPSSVARTHGPSASSLAGGNTKGATAQVSSSSLSVSDKNKESSSSNNVLSVVPSTESSQVTITKPMIPNRSLKPLVQDSNSVTAKENGKTKAAVCDSLKDDDEEEIQNQMKGVGRVNKAKKEDTQTYAKEGKGAEGVRELTRMQKEHQIQEQQALLELEKMRQEKMKMENNQLRLEKAQMEKQLEEKVSALKRMQEQLEEQDKATQAEDEQQQLTTEGKKTESDKELNSQTHLIGASIHRDVKIQDEGVAKLVKETSSSPAKGGSKPQLQGEVGTSKIPQADAGKPAQPTDQRSIPSMSITSVTPAPTVSSSMQNAKLASGTALTLPVGWEKKLHPASNKYYYIDHNTETTHWSPPAMGSGGAASTTTAAVSSTRPSSTVSSAKRPETKDSGSPAKQTTLSSTTKTHLKSDNSGTPQSSLKRSFSSPNIAQMVINEENGIHIPTVNRANKPVQRMPSSSVVQSPPPQKPLAVTRARNLNPVYGSQGRSLTGLRNLGNTCFMNSVVQCLSNSTPLTHYFITDKYVPDINRQNPLGRGGNVAQEFAVVIKAIWSGQYRSISPLDLRDTVTKYVPEFRKNIGHHHDSQEFLLFLLDGLHEDLNQVWKPFILKALLYDQKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLE9</accession>
    <name>A0A8B7YLE9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022093462.1">
        <property type="nucleotide sequence ID" value="XM_022237770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980795"/>
    <dbReference type="KEGG" id="aplc:110980795"/>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF0">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PARG helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="7">
        <location>
            <begin position="221"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="7">
        <location>
            <begin position="1238"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="867"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="907"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="950"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="966"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022093462.1"/>
        </source>
    </evidence>
    <sequence length="1334" mass="145069" checksum="AF9EDD9211BB8285" modified="2022-01-19" version="1">MVNQEPGPALLEGGTVPLPCDGPGWAGLRAALAGLGAVASPEGLLPSLGRVYRAAHPAQLSWHTGRPLAPTPHPFLGLGHFLEHVASEAEQERFFQRVLPTIARLAGHIEAWRPQEAIQYMVQQQESSVCLDRRFVASVVANAFLCTFPKQPNPQLNSINFDEFFQFLICSSTKNSQAAKLRCILNYFDRLADVDMERDLTGQISYIRQVLGEGEAMSLEGWLDSKVKLCPLTIKHKGLIEDAGSHALQVDFANRFLGGGTLLASRQQEEIRFCTCPELLAALLFTESLQDNEAVVVAGFEQFSEYTGYSSTLKFSGDHKGCAERNSSGDLNNTLIAIDAMPWTGYLHNQYRPEHLLRELNKAYVGFCYPKASEASVSTGQEEADSSSYHDALDQSLVSTDGAEFETASSGDDRSRKSSCNSTLQAYGSSLSRAITDIAIKDVTGSYPRPSLPRDESSVTSLSTVLTASNASTPVNEGSPRKLPGIAGEVAALEGYATGLAQDVLKEGGASGTGEGTRSDANTEGYKVEAQLEHQAMTLVREVISSAVGTVRERNEQDIPEKATASCDGENSKEESLRASGDAVDGATSSDVRMSGSTLAVMAPPLKQNESQAGLEFHSGESRSSKGSLADYSIISSASGQSSEGFVKLNGDADLAYRQRHPNQAFSAEVLAADIMQDALATLHKHFNIRSGIPTTISSDSLNLSESHSEMSAARDRSGSFDMLTSGDISSSPSLSEYVRVNPFSLDGLAEDIMSSAFQQLQQILEEKASRDMNGNQKNNKMVILSDTDESLRNSLNNNAPSDYEALAQEDIRNGNTLRSSTQDSISREENRRTGAADSFAERLVGHVFNDSLLDLQNQSLLSNNRVRHHEEPDTPPPSPTDPAEMEASLQASQSFDKSLVTISEQPAIEEPQPLYLGDKRLSADSSGTESSQSREARIRECAEQLVARTLPESMRLLGGSAQTTSSSSSRRTSSPRSSIPDSSNRSSLDCFTEDLLRIGNINPTGKRPSRTEESLAFFAQEIKRMAEAEEKSSKKQKEDFADFAIELQRGSTRAQPDESPAMHSQSLEVLADRYSVQVISDVFVQLYGEPWSEAEHSDPEEENEMQSTSECVLSVTEHPQRRPSEQDLMSLASNLANSILEAALRVYREEHLHLPDVHVNLDAGSSDLGHDQCSPPEKADGDATSFKTCTLDEFASVTVDAATEEAFTHLTKFLKDGGRLVQEVDEGDLLRELGPTGQRPISTGNWGCGAFGGDPQLKSLIQWMVASQVGCPRMIYYSFGDERVSRLQRVVTEITSRQWTVGDLLGAVLDHSWLTLNVDAEPLNLFDRIINSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLS1</accession>
    <name>A0A8B7YLS1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lectin L6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110980755</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tectonin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093395.1">
        <property type="nucleotide sequence ID" value="XM_022237703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLS1"/>
    <dbReference type="GeneID" id="110980755"/>
    <dbReference type="KEGG" id="aplc:110980755"/>
    <dbReference type="OMA" id="VWGVNTH"/>
    <dbReference type="OrthoDB" id="166585at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006624">
        <property type="entry name" value="Beta-propeller_rpt_TECPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051513">
        <property type="entry name" value="Tectonin_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23250:SF3">
        <property type="entry name" value="FISH-EGG LECTIN-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19193">
        <property type="entry name" value="Tectonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00706">
        <property type="entry name" value="TECPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034554169" evidence="3">
        <location>
            <begin position="27"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093395.1"/>
        </source>
    </evidence>
    <sequence length="282" mass="31385" checksum="B687DB6DBC4D78C7" modified="2022-01-19" version="1">MVFKYQSLVWAVCILCEVLRPNRVSACPQATTSWTQLSGALKHVSVGNSGVWGVNTHNWIYYKGTSYGEEESPTCRAWEKVSGSLTQLDVGHNIVWGVNVHNNIYYRQGITASNPKGRDWVQVSGALKHVSVSQRGHVWGVNRQDYIYHRIGASNCNPAGDSWRKLDGRLKQISVGSGGVWGVNSGNNIYYRVGTYGDLPSDPDGSDWKQIQGSLKYISSADMIYGVNSNDNIYYRVGVSEGTPWGTRWEQIPGALKQIESLSCVVWGVNRSDNIYKKKTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPD9</accession>
    <name>A0A8B7YPD9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP-binding protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110981232</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094315.1">
        <property type="nucleotide sequence ID" value="XM_022238623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPD9"/>
    <dbReference type="GeneID" id="110981232"/>
    <dbReference type="KEGG" id="aplc:110981232"/>
    <dbReference type="CTD" id="8225"/>
    <dbReference type="OMA" id="IDVANKC"/>
    <dbReference type="OrthoDB" id="10268034at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000886">
        <property type="entry name" value="Putative GTP-binding protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="entry name" value="GTPase HflX, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229:SF0">
        <property type="entry name" value="GTP-BINDING PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="GTP-BINDING PROTEIN HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="5">
        <location>
            <begin position="341"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022094315.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="63831" checksum="5A4A714A7560C9B9" modified="2022-01-19" version="1">MAALRIMVKTILTRGALTSYQTAVTNYQVLPRAFRHTCQGRTYVSLRPNRTGGRFHSRASAKVQFLHVKLTQALFPRSSYRTAHCLYRKHKKAKGHQTTESSGSNEAIVEDGLDESEWDAIFLQEDRIAEEVDPPPLGGHRFLVLQPDLKVKGTKHGPDTNPQLQLEESIALIETIPGWKVVEGLVQGVKEPSKKLVFGKGTHTQLTEIIQSRPEITAVFLSMEKLSALQQKELEETWGVRVYDRYAVVLKIFKEHAHTREAKMQIALAEIPYLRSRLRNESSSMDQQRGGHSFISGGGETFLTVQQRVLKEREQKVRKALEQLKKKRGLLRSSRTKKNYPVVSVVGYTNAGKTTLIKALTGDVSMHPKDQLFATLDVTAHAGTLPNRMPVIYMDTVGFISALPHNLVASFSATLEDVLLSDIIVHVRDISHPDTVAQKEKVLQVLSELGVSDSLMDNMVEACNKADKIQEPAGAEHETSGIVISAETGLGLDKLRDCIEARLLEVTDIIPCRLEIPMSGPHLSWLYKEATVTSTEAVGTDNDAQTMIVNVILRAATFSKFRSKFGDLRKSSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQ61</accession>
    <name>A0A8B7YQ61_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin-7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110981797</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095413.1">
        <property type="nucleotide sequence ID" value="XM_022239721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQ61"/>
    <dbReference type="GeneID" id="110981797"/>
    <dbReference type="KEGG" id="aplc:110981797"/>
    <dbReference type="OMA" id="ILCVEAH"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000005">
        <property type="entry name" value="Aquaporin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022095413.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="31461" checksum="028E6AE61263475C" modified="2022-01-19" version="1">MVWTRHLRIRNQWVREFLAEFLGTFILMVFGDGNVAQSVLSSSAAGEFLSINVGWWVAVTMGVYASAGVSGGHINPAVSLALAVVGKFSWIKLPMYVLAQFLGSFAASACLYGVYLDALNAYDGGNRTVIGPKGTAGIWATYPQDFLSLQGGLGDQIFATGLLLVCVLAITDKRNDGAPSGMAAIMVGLSVLGIGVSFGFNCGYAINPARDFPPRLFTYCAGWGVDVWVPNGMHWWWVPIVGPCIGAVLGALLYILCVEAHHTPEDELPITEGDAYAVSEDVVMKRREEDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQF6</accession>
    <name>A0A8B7YQF6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Testis-specific serine/threonine-protein kinase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110981846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095509.1">
        <property type="nucleotide sequence ID" value="XM_022239817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQF6"/>
    <dbReference type="GeneID" id="110981846"/>
    <dbReference type="KEGG" id="aplc:110981846"/>
    <dbReference type="OMA" id="CDNIMLD"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="39"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022095509.1"/>
        </source>
    </evidence>
    <sequence length="564" mass="63389" checksum="51260F3D822AF963" modified="2022-01-19" version="1">MGNERIFYTDEALHLKRKGEGVWMPEKGKSVLDSLQLDLVDKGIIGEGPYSQVRKVYSRKLNRYFAFKRISKLRAPKEAVDKFLPREITIMQQLAHERLVDMEAVLVTEHYTFILMEYIPHGDLTNYINRRGHLCEEEARMLFHQLLDAVSYLHALDVVHRDIKCDNIMLDEHYNVKLGDFGFATMCEAGQKLSEFCGSYAYTAPEVLAGEAYGGKKADVWSMGVVLYAMLCGRLPYHDETLDILIDNIHNPQGKLLFHKKVSKDCRDFVRSMLTADPKARASISKLKRMDWLNKPIDMSSADYKTPQSSFESVGPAPAGGRPRRASLDMNAEHGFFESQRVMENEKQRPHTVTDVLRAVAVRHAFGESTTDIHKHVGLRPGTHLKATDVGLTGPAGRRISVQLSQQNLPLFAGGVTNKPVDTPESTRRARRASLMPDRKDSLSMLTSTARKGIRRGSLAPYQGALRATGSQIMMSNEDLMASAINLNQTKVNKEIHDMHYYTGAKVARAAGAKRHKSAECTRRNSVFTDALKLRSQPNALDPAEQALVNLFRSKCEKIKDMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQI5</accession>
    <name>A0A8B7YQI5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein LOC110981585</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110981585</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094937.1">
        <property type="nucleotide sequence ID" value="XM_022239245.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981585"/>
    <dbReference type="KEGG" id="aplc:110981585"/>
    <dbReference type="OMA" id="EMEDGIC"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000068">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF294">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="14">
        <location>
            <begin position="157"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="317"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="431"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="11">
        <location>
            <begin position="133"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="317"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022094937.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="69103" checksum="5415E9E1AD2EA77D" modified="2022-01-19" version="1">MGYLAAQHWFVPCACSSRVQISREHDREPTPRKKGLITATTMKRAKGGSMMAKMFLFTALLICATTVVRSMTVETAADAMMYLSHYGYLQPIADGSNVSQEEMEDGICKFQYMANIPMTCELDNETLTMMKMPRCGMPDVTDESPVDARRKKRYTLYERKWSKTNLTYRIDSVTPDIASLSDIENTFAQALQVWADVTSLTFKRVLGDTSADIVINFFSGEHGDGNPFDGPSGVLAHAFYPENGNAHFDENETWTINSSSGTNLLQVAVHEFGHNLGLRHSNVTGAVMEPYYRGYNPDFKLHEDDIAGIQAFYGLNPESTTTPYSTTTPRTTPNPEPTTTLEPSTTPEPSTTHELTTAQEQTTVTTPGTTPPGTWNNLEMTTSPPETSILPETNTLTIAQETTTPXETTTLTIDPDPETTTLSETTKIPETTVPPVTTIPPKMTTPLVTMPPAATTSPETTTKQASTTPSETITPPSTPPNVLETASAGGISNLETVFIILSSTVLLLVVAGLVLCSCLLMRRLHEKRISHYQDQRYSYAPRYHNGIFDHTLSRKEGYIETGFTSDEGQANRISLNKSLYFRQFGKPDLPIRQEFIRPYVASGLEASHIYFGEDRPRGNTDGGVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRP9</accession>
    <name>A0A8B7YRP9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Uncharacterized protein LOC110981781</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110981781</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095362.1">
        <property type="nucleotide sequence ID" value="XM_022239670.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981781"/>
    <dbReference type="KEGG" id="aplc:110981781"/>
    <dbReference type="OMA" id="INDCPAT"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055123">
        <property type="term" value="P:digestive system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048592">
        <property type="term" value="P:eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048732">
        <property type="term" value="P:gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035282">
        <property type="term" value="P:segmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="45"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000659">
        <property type="entry name" value="Crumbs cell polarity complex component 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000012">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000230">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000246">
        <property type="entry name" value="EGF-like repeat and discoidin I-like domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000172">
        <property type="entry name" value="FAT atypical cadherin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000050">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000125">
        <property type="entry name" value="Neurogenic locus notch protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000565">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000143">
        <property type="entry name" value="Protein crumbs 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000321">
        <property type="entry name" value="Protein delta homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000610">
        <property type="entry name" value="protein HEG homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000006">
        <property type="entry name" value="Versican core protein-like isoform 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="81"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12916:SF9">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25024">
        <property type="entry name" value="EGF_TEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="81"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="73"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="73"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="38"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="65"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="49"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="81"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
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    <sequence length="4739" mass="501089" checksum="58BE5076D0218477" modified="2022-01-19" version="1">[encoded data, 4739 characters]</sequence>
</entry>
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    <accession>A0A8B7YST8</accession>
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        <name type="scientific">Acanthaster planci</name>
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</entry>
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    </evidence>
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    <sequence length="290" mass="32864" checksum="A5E709248A547AB4" modified="2022-01-19" version="1">MLLFAILPVLLICDVSVISARQVKMRMVNEPINTGQTWGNNEPEILKPKVKPANFSGPPHLKRLVGRCFSKTVNSYKYELCPFQNVTQHEQSLRWNPYSGILGIWQEWQIEGNVFKSMLMTEGDQCLDKSRKVTVHLECGALNSITNVSEPTTCEYAIVFVTPLVCHPHSLLVYPTLSEALRSRWDEIEGELFNEEITLQGYQKKLTQIFQDAGYVLDPSKREQLKAATKSDQLLAPQGDGFETLEACSAAYAVLEEEIRRLKAQLERQGQGQGQDPEENPLFNLDNIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUV1</accession>
    <name>A0A8B7YUV1_ACAPL</name>
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        <submittedName>
            <fullName evidence="9">Pleckstrin homology domain-containing family F member 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110982406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
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            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096467.1">
        <property type="nucleotide sequence ID" value="XM_022240775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUV1"/>
    <dbReference type="GeneID" id="110982406"/>
    <dbReference type="KEGG" id="aplc:110982406"/>
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    <dbReference type="OrthoDB" id="70570at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15717">
        <property type="entry name" value="FYVE_PKHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01218">
        <property type="entry name" value="PH_Phafin2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000167">
        <property type="entry name" value="Pleckstrin homology domain-containing family F member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051765">
        <property type="entry name" value="PH_domain-containing_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037871">
        <property type="entry name" value="PH_Phafin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280:SF3">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46280">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY F MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="7">
        <location>
            <begin position="152"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022096467.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="30478" checksum="C8BEC70E3CC39C7B" modified="2022-01-19" version="1">MVDRLVNSEANEKRISHVQACFGGSGQMLLAPGRVLVGEGVLTKLCRKKPKPRQFFLFNDLLVYGSIVMNKKKYSTQHILPLEDVRLKSVEDDGNLRNGWQIISATKSFTVYAATATEKSEWMAHINKCISDLLAKSGKKPATELSPVWVPDSEAPLCMLCKKSKFTALNRRHHCRKCGKVVCGQCSAKKFLLPQQSVKPQRVCNDCYEQLSSGQMSAQGKNPADGKRQGNSLNYGHEDDSSGDESTDEDEDETPGDMAPVEDEHPTFYEGNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXL8</accession>
    <name>A0A8B7YXL8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110983265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098078.1">
        <property type="nucleotide sequence ID" value="XM_022242386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXL8"/>
    <dbReference type="GeneID" id="110983265"/>
    <dbReference type="KEGG" id="aplc:110983265"/>
    <dbReference type="CTD" id="9688"/>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="3 5" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022098078.1"/>
        </source>
    </evidence>
    <sequence length="866" mass="98128" checksum="96C2E2A8B537A5CC" modified="2022-01-19" version="1">MNLKLVRALPTCAVKYERNNSSCFAVGIFLDLDSHTKAEMDGDSFEDLLRDAEQLTANVDSGGELPRVERNLHQIMETSQRLWTKTAQVGTPDAADVKASILLGSKGLDVPRISQRLETLSATKTFEPLEPIADTDIQSFLRNERENAVLAVIQETKKNTLQQTEKRFWETMQSEWQEQRQRILNALVGTGEDMLDIGPDTESVLSETMAMDGRSAMSSMELAYAREVYKYNDRVVRGGVRPNLIRLFEQISLQFEDNRVSELWAMVREMTSVPLVATADTVQVRSSQEMQMAFVRQARIFLEKSYLKYISTIVGENLQRAQVGGIPGTYPLVQGFLKVKLPHPIPGLEDGEVNGQPVWPIIYYCLRCGDLDATLHAVQRAAHDLGEFEEYLKEYMDSEDRRLSPNMQTKLRIHYRSNVRNSPDPYKRAVYCLIGCCDTTDSHSEVISKTEDYLWMKLSQVSFVEDSGPSSSDRLTLPQLQTTLLEEYGEGHFSAAQNPYLYFQVLFLSAQFEAAVEFLARSDLRLRCHAVHAAIVLYEMGLLVLPANIQMQVLSKHLDDPPPMRRLNFARLISMYTSKFENTDPREALQYFYLLRGLKDPKGENLFVACLSEMVIETREFDALLGRLGSDGTRRPGAVDKFQANTQRIVETVARDTEAKGLFEDAVKLYDLAGNADKVLEILNRLLSPIVAVPKSGQSDRQRLQTLAVAIAGRFRSQCVTGNQANTKSFYLLLDLMTFFDQYHGRELDRALETMTSLQLVPLTPETVDDKVNAFKQYTDEVRRNMPDILLATMNILHTKYRTIRNSTLQNAQGRATVRLEDGGKESYLAHLRKQAKSLITFAGMLPYRMPGDTNARLVQMEVLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYG0</accession>
    <name>A0A8B7YYG0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein limb expression 1 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LIX1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097525.1">
        <property type="nucleotide sequence ID" value="XM_022241833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYG0"/>
    <dbReference type="GeneID" id="110982996"/>
    <dbReference type="KEGG" id="aplc:110982996"/>
    <dbReference type="CTD" id="128077"/>
    <dbReference type="OMA" id="DWVAREH"/>
    <dbReference type="OrthoDB" id="6250996at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051436">
        <property type="entry name" value="Autophagy-related_EPG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029270">
        <property type="entry name" value="LIX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139">
        <property type="entry name" value="ECTOPIC P GRANULES PROTEIN 5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31139:SF6">
        <property type="entry name" value="PROTEIN LIMB EXPRESSION 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14954">
        <property type="entry name" value="LIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022097525.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="34041" checksum="77B67FBA333A4F68" modified="2022-01-19" version="1">MANRPYHMSSGAGPSRQHQAQAMAGLTPRGRGMGQRHPGAPMSDQKAKTVLKEAVDAVVNSFAKHTQGYGRVNVVEALQDFWQMKASRGAELKGGPLVIYESVPSSCPPYVCFVTLPGGSCFASFQNCPTKAEARRSAAKIALMNSVFNEHPSRKITDDFIQKAVTDAKKSFQGSPEDENDPNTSLGAFRFMLESNRTKSMLEFQELMTVFQLLHWNGSLKAMRERDCSRQEVLAHYSHRTLDDDMRSQMALDWISREQEIAGIIAEELQRADDEIETARLAGRELRFPKEKKDILMLACSQLGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2D6</accession>
    <name>A0A8B7Z2D6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protein TANC1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110984184</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TANC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099779.1">
        <property type="nucleotide sequence ID" value="XM_022244087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110984184"/>
    <dbReference type="KEGG" id="aplc:110984184"/>
    <dbReference type="OMA" id="TSADHAC"/>
    <dbReference type="OrthoDB" id="5958958at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058018">
        <property type="entry name" value="AAA_lid_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058056">
        <property type="entry name" value="WH_TANC1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF55">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25520">
        <property type="entry name" value="AAA_lid_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25521">
        <property type="entry name" value="WHD_TANC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1548"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1614"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1647"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="1680"/>
            <end position="1712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="60"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="723"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1890"/>
            <end position="1991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2037"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2273"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="301"/>
            <end position="313"/>
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    </feature>
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            <begin position="314"/>
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            <begin position="456"/>
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            <begin position="512"/>
            <end position="529"/>
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            <begin position="538"/>
            <end position="549"/>
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            <begin position="569"/>
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            <begin position="652"/>
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            <begin position="1981"/>
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            <begin position="2057"/>
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            <begin position="2161"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    <evidence type="ECO:0000256" key="11">
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            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
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            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
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            <dbReference type="RefSeq" id="XP_022099779.1"/>
        </source>
    </evidence>
    <sequence length="2331" mass="254738" checksum="AF5C3DCA15F6D87E" modified="2022-01-19" version="1">MMMLLDGAATMEADTSHCPCCREAYDKSRKRKLTDACGHARCYACMFSIESCPLCATKEPTLQNGETEPDRVPRSNKPPTPPPKPKNRTPRSSMHVTTPTSPIAPTARGVNGNSPSNFPDIQPPPALPMPAPAPLGAAERPLEKLAAKVMQESRADQPLKGPVQRRKFFDDPTMSPSALAQYTNRQDPPAPPQLFIPPPPSQDPTSDEGSESSYDTGDISDCDSCKDDRRTPPPAPSEAAEALMDRLGFLFKQAQMPPPPESPSSERTVQATFFPPLHSTPVANTAVLRDRSQSFPVAETRTSEGLEGNKHQGQESNSRQPTQGRQGFQIQQAKKWSSVKQANPDNSGNQIFKGRSSLRTSAELASQRPQPLTSANQAKQLVDPKVTKPVVQEAKVRRTVQEYTQNPAVYENPVDIQPNVGKDRKVNGAATNGGQNRPNSFIGQDSEKANVPVRAHTIDSRVSKTKESQPPIPAPKPSSRPGSYHNQEMGKSCLEEQLKELFNSADAEQQEEQDRPVMDTKSPSVREKPIVPPKAARSPSSQKSNSPSPSKEKSETTAIRHSTPVGGVLQQNDLANQRPRSMEHIRTSSPSMASPRVLHSRGRSMDSTLKDSSLSFADSTGPSLTVVSSMEGFDMSSKIEGTPGLNGKSQKESIASQKHMSTLPASTPKGPASTSQQSRTLPHSNPRSSISQSDSNLRALPQVDGGGQVPKQVQGSLKHIAVDKQDSDSIGSSSPEHAPNRRQSTKPALIKQHSDLLAESRDVVNDVGLLSPVQQDTSASGLLLSNTGVGRHRSASTSSPEALDDIPLFGGRRAAMVRRSLRDKEPPGKASTELMKGRLPVYKPSQLLLRPITFEIPGFHQDNPVIGREWLFIDLEHSLIKDTTSKLRGVVLLGEVGTGKTTIVAKLVSLSILSQFLVNDSSPEIALSDKNSNPPNGMNVYSSSSTLTRMRQQSEQALMSLASQIGAFHVCQADNSITCMVPEFVHSMAAQLAHCLQPYKELLLTEPQLQALLSMRDCTQNPSEVLFRAILEPLSMLKSQGRITMETCIILVDGLSEAEFHKSDYGDTIASFLTKNIMKFPSWIKVIITIRSSLVDITKMLPLHKICLDKSTTNATSVSSEHVQKDAEQYINYRLQQSAAVRDNVLLNGKLEHSGQSRFRSHLQALSRGCFLYLKLTLDLIEKGHIVLKSASYKVLPINLSEVYLLLCNLKFQTTRAFERIAPILNIALASLYPLPDPLIFDVMNAGYITSYVDKDDFRQRIEMVSSFLCLRKDGTRMFYHPSFREWLIRRDEGESVKFMCDHRSGHALLAFKLSRQSKRLNRDQAFELGHHILKAHIYKTLGRQLGGFSARELQAVWMYLNTDQLSNSLATRRNLFSPNVKVSRLLLLAGASPNHHTDVLNNAPVLCVSAREGHTEMVSLLLEFDADVNEECDRGMGPLSYASANGHLEIMRMLIIKKSLVLDTDKNGKCAVVHAAEHGHLAALSFLLQCDWTGQETDKLNSKSVAQQAFVAAAGNGHKEVCGFLLDLPGPEADSHLVTVDQTDSLVGETALTAACTNGRSEVLKLLLKRSASVHAMNQVQMSPLICAVRRGHWEIVDILLFNHASLEESDRHGRTPLMLAAGEGHLAVLEVLLSKGASVHKCDKEGLTALCWACLKGHFNIVRSLLERGSTIDHADKNGRTPLDLAAFYGDPQVVQLLVEKGATIEHVDNSGMRPLDRAIGCRNTSVVSVLLKKGAKLGPAAWAMATSKPDILVLLLKKLMDDGNALYKKEKWREACHKYQCALKKYPTEAFGDEIRTFKELKVNLLLNVSRCKRKLEDIPGAIELATKALEIKPKCFEAFYARARAKRAIRQFGPALQDLLEAIKLAPNNREVRRLLVRVKEECKDETKKQKEIPATTATTTTITKDSPADNDQGRDSGVPISQPGSSQASENEISPPDASKRDGVLPGSEPIPVQQRQVLSSSEEQLRTGSIPRSIPSKNVSNSQTMPSSAKIAYSGMANSYPVTGTLVMGDPHGLDAGNQDIQRPLTLQIALGQPSSGSKPVQQQVSKHVPQEQVSRQQVARQQQQQKPQQQVTPRQHTQSLQHRSTNPAQFNNTAAPRPSAVRTTSQPPPTANFMPVASHPVNKHAPSTNTHPMVANPMAHRPLPKRPDEDTAVTRVSSAGSIQGNPTELGAANLQNVSSRSSQPPVKLRAKQRRDIGEPVVSHRLSYTLENSDEGSLENLAQSAPVPKPVAHRAILPRQASPLVAQQPEADSQHGAVRTVVPQPAIQRAGAPQHGEAGNANRQQPPQPMVRQGSSGSLQPQQNMSGQEFPRPSAQTLFIGPTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z591</accession>
    <name>A0A8B7Z591_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110984695</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel HCN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100809.1">
        <property type="nucleotide sequence ID" value="XM_022245117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z591"/>
    <dbReference type="GeneID" id="110984695"/>
    <dbReference type="KEGG" id="aplc:110984695"/>
    <dbReference type="OMA" id="YFVQHGC"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098855">
        <property type="term" value="C:HCN channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003254">
        <property type="term" value="P:regulation of membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013621">
        <property type="entry name" value="Ion_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051413">
        <property type="entry name" value="K/Na_HCN_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45689:SF5">
        <property type="entry name" value="I[[H]] CHANNEL, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08412">
        <property type="entry name" value="Ion_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0114">cAMP</keyword>
    <keyword evidence="6" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="514"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="667"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="698"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022100809.1"/>
        </source>
    </evidence>
    <sequence length="723" mass="82405" checksum="785C3B7E9E9FF77F" modified="2022-01-19" version="1">MSSRDPRSLPPLRSNKVMQEPLTRGSSESIGSDEMAVQHLLPAIEEQVPLTSDTHEANHVILKSSIKQNGPKSGSTGENAMGHVAFDIENMAEGNREETSKENSKESIKASLSLLGIPQPRKESDGLSGLKNTFIRRQLWQMLEPTDNRLSMKLFGSRKGLQMEKKRLKAAGILIIHPCSTFKFYWDLVMVLLLIANLVTLPVIIAFFYQEKLSKTWSVFNCSSDTLFILDVIINLRTGYMDLNTAEQVILEPKKIALHYLKSWFAVDFVSSIPMDCIFLGVDGGNENKLYEVSKAFRIFRLAKLLSLVRLLRLSRLMRFVRQWEQVFNVAGAVIRIVNLIGIMLLISHWNGCLQFLVPMLQHFPQDSWVSINDLENAHWWEQYTWALFKAMSHMLCIGYGRFPPQSLTDLWLTMVSMICGASCFALFIGHATNLIQSMDSSSRQYREKLKQVEEYMAYRKLPSEMRERITDYYDYRYHGKMFNEDVIFSEVSAKLKQDVANYNCRELVASVPFFQNADPNFVSRVVVLLKFEVFQPGDFLIREGTYGDRMFFIQQGVVDIITSDGQVATTLSDGSYFGEICLLTEERRVASVRTDTYCSLYSLGVNNFHQVLREFPAMRKTMQTIALRRLNKIGRTSKVLVAALRHHNTTSQNSAVSSSLLFSLPPESSSSAFSEHNRRSEDDMEDESNERVLQVTEGPSQTPTQTPITRYYSSPDNFPPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z612</accession>
    <name>A0A8B7Z612_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl-CoA-binding domain-containing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110984835</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101069.1">
        <property type="nucleotide sequence ID" value="XM_022245377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z612"/>
    <dbReference type="GeneID" id="110984835"/>
    <dbReference type="KEGG" id="aplc:110984835"/>
    <dbReference type="OMA" id="ARSKWQA"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="7">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022101069.1"/>
        </source>
    </evidence>
    <sequence length="254" mass="28224" checksum="895403A0A4DAD705" modified="2022-01-19" version="1">MESDDSDFGDTSVGPSGDDGLTREFHQAAQRVQMLVSGLPKEKLLYLYARYKQATVGKCNTLRPGLFDFQRKQKWDAWHGVGEMTKDVAMAEYVAAVKEIDPDWSSKTKGGGGSRGGMGVGVSTMCKEDDDICDFNKTVFDWCKEGNVEQVRRLLDEEGLEVNDTDDEGMSLLHWSCDRGHTDVTLMLLECQADVNILDEEGQTPLHYAAACEHVAIAEILLKYGANRELRDNEGCTPLELTSDTVIQEMLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z663</accession>
    <name>A0A8B7Z663_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription cofactor vestigial-like protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110984501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022100442.1">
        <property type="nucleotide sequence ID" value="XM_022244750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z663"/>
    <dbReference type="GeneID" id="110984501"/>
    <dbReference type="KEGG" id="aplc:110984501"/>
    <dbReference type="OrthoDB" id="10069705at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011520">
        <property type="entry name" value="Vg_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950:SF15">
        <property type="entry name" value="PROTEIN VESTIGIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07545">
        <property type="entry name" value="Vg_Tdu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022100442.1"/>
        </source>
    </evidence>
    <sequence length="386" mass="42069" checksum="31BBFA175442E44E" modified="2022-01-19" version="1">MDIPRVQDFVVPYSSAVMPNACAVWSVGGVGTICLDSQDDLKKFGHYKMQEPPDHDPSYTPHTQSVPPATSTSTGYSSSLYHHHHALHSHHGSPPANASGLPHQASVKKEDKPTVEEAEPTVEAEYINSRCVLFTYYTGELNKVVDEHFSRALSQPSSFPPDGRIGVSGGDSTGSQGKQSDGSTWNSKNGESAIPLMCQRDLPASFWNSNYYNHIKYPHPHHHPHHSTPISSSGSSSSSSSQGPTSNPAHPGHHEPLFTDPYPSPLHHRPVHHQPDPWHYPFVSQGSYSHHHRSGLHDLSYGMSSGAGSAFNPRYSSLLIQPSVRSGRLPAMPGQCDFTKGSEGWPSGYSHGHSQQLSTEITSYGMESASTSALEASDTSKDLYWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6R5</accession>
    <name>A0A8B7Z6R5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitotic spindle assembly checkpoint protein MAD2A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitotic arrest deficient 2-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101334.1">
        <property type="nucleotide sequence ID" value="XM_022245642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6R5"/>
    <dbReference type="GeneID" id="110984973"/>
    <dbReference type="KEGG" id="aplc:110984973"/>
    <dbReference type="CTD" id="4085"/>
    <dbReference type="OMA" id="WQFDVEI"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990728">
        <property type="term" value="C:mitotic spindle assembly checkpoint MAD1-MAD2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="9">
        <location>
            <begin position="32"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022101334.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25220" checksum="4470ACBBEFFE6BA6" modified="2022-01-19" version="1">MGSDYIMQVDVAKLKKMAATLQAPKANTITLKGSSEKVSEFFSFGINSLLYQRGIYPPETFTRKQKYGLTLFMSTDKALQDYLENVLRQLNKWLNEKTVQKVVVVITEVESGEVQERWQFDIQCDKSMTHESQPREKSNAEINKEIKAVITQITATVTFLPLLANPCTFNILIYTDKDMAMPEQWEESGPSLITNSQEVKLRSFATSIHKIDAAVSYKDDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8S0</accession>
    <name>A0A8B7Z8S0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 63-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985384</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102058.1">
        <property type="nucleotide sequence ID" value="XM_022246366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8S0"/>
    <dbReference type="GeneID" id="110985384"/>
    <dbReference type="KEGG" id="aplc:110985384"/>
    <dbReference type="OMA" id="FWKENTR"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102058.1"/>
        </source>
    </evidence>
    <sequence length="638" mass="71701" checksum="BD33BBE66B07FC51" modified="2022-01-19" version="1">MPSHRHSGAKLLRRPLSPPTPPAAKPSESNTGLSRKTDNGNLQSRSLPSLSSLSQDAGEEDDMEELVFQGRNLSPVPSVIPSLASDFQEAQLAPQNTPKIPLMKHSPRARRSHSGPVTSPRVPPLSKTDLPFILDMRYKPRGASAETFRPGSLVQPYKPRGPDGFPFRNPKRLPEVKKELLYLDHEHMRYHLPPDFTLEDFQLEFATYGRPFQRENLKKAILSKQNYKKLTTLFASFVDSPVQEKVNTVELKGEDIPEVVPRVPQHQLLIEMASIIRQQMRTMINEEMVGSLSGPVTTDQPTTVLTTPATAALAYQQAESASSALAALSSRQADSVNEVMFNMPVSKYFQGSRRSNSPFNEQDSSTITPSELAILDCLVNGGLALSLKAHFILALPDITPLTKTLTYLNLSFNDFRVFPPELLTLRSLEVLKLRNNPLKELPYDIHRLSKLRTLVVSFNLITALPPSLFTLPLQFLDLSYNKLTFLQSEIRHLRSTLRELNVEGNQLPALPCSALKLRKLRYLRVTNNFMHPLFWKENSQNDPQRLLDLASLAVKQSGLDRFKPSVLPDSLHSVLNRYSRCDCCQGPLYGPGLRVIRPCSKAFGVRKLPFLFTSCSPYCRDSFLTSVESLTQMLYMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9N3</accession>
    <name>A0A8B7Z9N3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110985570</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102378.1">
        <property type="nucleotide sequence ID" value="XM_022246686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9N3"/>
    <dbReference type="GeneID" id="110985570"/>
    <dbReference type="KEGG" id="aplc:110985570"/>
    <dbReference type="OMA" id="WNCTTIE"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19335">
        <property type="entry name" value="Wnt_Wnt3_Wnt3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009141">
        <property type="entry name" value="Wnt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF100">
        <property type="entry name" value="PROTEIN WNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022102378.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="41783" checksum="9F2BD9C2EDA73472" modified="2022-01-19" version="1">MELKAWLSICLIFGSFTVRIGHVYASGIWWTLGTAYTFSEDQIFDYPCRRIPGFQNRQLRFCEQNEEFVPTVAEGAKQGIDECQFQFRGRRWNCTTIRGDNSVFGKILQFGSREKAFVNAIFSAGVAHSVSRACSRGDYLQCSCDTRHQGPADNPHQIIPNSTWRWSGCSEDVDFGLEFSRKFISSKELRTRARVIMDRHNDEAGRKAVADSLELKCKCHGISGSCELKSCWWQMMPFRSLGAKLKDKYDSAAEMRVVRQSEARGKVEVLEPKSLLYKPPTKADLIYYEPSPDYCRYDPELGSLGTVGRSCNRTSDAIDGCQLMCCGRGYNTIRKQVVERCDCKFVWCCKVICDECVRNYELHTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAZ9</accession>
    <name>A0A8B7ZAZ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110985336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101990.1">
        <property type="nucleotide sequence ID" value="XM_022246298.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110985336"/>
    <dbReference type="KEGG" id="aplc:110985336"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034403439" evidence="2">
        <location>
            <begin position="26"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="3">
        <location>
            <begin position="37"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
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        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
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        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
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        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
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        <location>
            <begin position="484"/>
            <end position="498"/>
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    </feature>
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        <location>
            <begin position="642"/>
            <end position="656"/>
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        <location>
            <begin position="686"/>
            <end position="695"/>
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            <begin position="705"/>
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        <location>
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        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
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        <location>
            <begin position="827"/>
            <end position="837"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="861"/>
        </location>
    </feature>
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        <location>
            <begin position="862"/>
            <end position="881"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="924"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00409"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101990.1"/>
        </source>
    </evidence>
    <sequence length="924" mass="102110" checksum="34981F5CBD7964A6" modified="2022-01-19" version="1">MAQSTCKTAFLSLLLVLLVVSCKSASQHVSLQRENENSAFIVLQGNTFELSYEISFGNLAQKLSFHCSNGKDIDISLPNMMTESSKTSTGNYSGSHPYNGKEQKKTLKLVVNNAQQGDSGLYKCQVHASFQNESTRTTSDSVTLTVTEEPACLVIPMISEMKGDSKIFRCITAENDPILYFKLESPNKHVQQIQKFPSQPGKITLLNVTETLNDIVLNCTTTESSCSNDPIILENTKPQTAPTTTELELSTKTPPSSSLGSPDIHISVKVAVPINTVLVIALIVTWCVRRKRSRNGGPPSTKDRRDDISPMDGADHPTSRPMTHPDLPRQEDEGTRLYEEINECVPPALPSRTTLLTKKSGPGRHSKKRSHRKTRTRRTKATDSVPNGSHAYSQVPLEASPDRNDEASNSAENILGTERLDQGKPLEEKGNVHQTGRKKLEPGYHIVLPSSSDSDDQDDDSSVDSMIKVPGQDYSNKKDDVHPNKQTKSGPNYFTVNPSTSDRDDDSGVDEDKVTTPDSDDSAPGPFNESNIYVADTSAWQMQELYLIPHANNTEVTNQGELPDDNETSTDQHEIEASSEIQTANKQREIIHPGDTLNGTQTRMQSVAQGEQTYDTLEHQTTVIRNQIIQRPTIPHASIDPGEAHYDKTNIKKTDQSESSSRRVRNSSDNKISKTNGGMQGPTARNPKTSPTAQHPTVKIKDSRPTSNSSQDALKTKMTVTPAQQQDKTRDYSSLPETRPTVESSGLLHMPKEHTYDSFNRGNSMRRNQLEGYEQVSESKPMPAAKPYIIVNLDKPAMRNQNERKSRTPDLIPDHPYEVPQARHPNPTASDEQNSDSCAAANDEASNRHSWSGDDARRTHPDNTAQNSPRIPTSKSGNSRVEQPYDVPRPCQQVSSRPPAKQQVPAVDPSDTMRQETQLDGTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB08</accession>
    <name>A0A8B7ZB08_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase MYLIP-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="nucleotide sequence ID" value="XM_022247167.1"/>
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    <dbReference type="GeneID" id="110985806"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Band_41_domain"/>
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        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
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        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
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        <property type="entry name" value="FERM_N"/>
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        <property type="entry name" value="FERM_PH-like_C"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280">
        <property type="entry name" value="4.1 G PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23280:SF13">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MYLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Second domain of FERM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102859.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="59950" checksum="815A187ADD2A8862" modified="2022-01-19" version="1">MWCFISESPYIVREYHLPKDSHGQVLMDKVCDDVGLIEREYFGLRYRSKKGELLWLNLRNPLKLQLNTKPPHRLSLQVKFFVSPQELQQTISRHVYYMTLKNRLLQGHYKVNESEKFQLCVLMAQAELGNEEAVLDSQYQSILPELSEHKLLQVKEAHQNCGAELTKTQAEIQFINKINKLPGYGVEYFAAETMDRTKVVIGVHSGGLQILSKERDVINNIKFEDISKVSYHQNRFSVHFYPSSDEANEEDVVSIRKFRLTSRKSAQALFRAFTESHTFFRCENVERVVREQHSHTGWGALLALFRPHTNYGKIYRFDITKTRRQTYDNAWHLLHHDSSPPPQRFSVDLDTRLANSQPYSTQTLRSTHSQEIMLSRQPSRLISSQDAVNVLIGQESSLKLIFVEYSCDNGVEYSRDGGVEYSRDGGVEYSCDSGVEYSCDGGVEYSRDGGVEYSRDGGVEYSHDGGVEYSHDGEVEYSRDSGVEYSRDGGVEYSCDGGVEYSRNSGVEYDVILVEVVAGDKYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZD84</accession>
    <name>A0A8B7ZD84_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NACHT, LRR and PYD domains-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103634.1">
        <property type="nucleotide sequence ID" value="XM_022247942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZD84"/>
    <dbReference type="GeneID" id="110986231"/>
    <dbReference type="KEGG" id="aplc:110986231"/>
    <dbReference type="OMA" id="CAILEHI"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="167"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022103634.1"/>
        </source>
    </evidence>
    <sequence length="839" mass="94827" checksum="595C50E406DCDD46" modified="2022-01-19" version="1">MGAVWSWLLGSGNPSQEHLQPASLGASNVDSITQHATPAANFPPNVAVTGRNNPVFLNRVEGSIFNFYAETPKNEKGHLGINCAEQLKTYYLKEMSTIPIHPILLSTTRKIKDIFIQLLLRKETHRTRRAEKGVRLRADSKECYPDNPIMEPLKSQDDLMQLLIDDGHVVVVGTAGKGKTTLTRKIAYDWTCHASDSCLSLFKLVFVLRMKEIQVGSGILDSMRKILPTDVGVSRRHLQHIIHENQREVLIIFDGLDEASSTVLEGPVHDDDYPIKDVLSAKALRNCSVLVTTRPHKMDQLRSYFKNYTVVETTGFSSDNRNKYIQQFFSDDKSIGEALIKEVDVTAFIHTLAQCPIMLLLLCLIWNHDQTLPQRLTELYERAVNVLVDHLSSKGSPNLHDPTKMDALIEVIGRVAFEGLINPLGERLVFSPEEFSNNLEYAFQIGILFQETRIVVEHIVRTINFLHKSFQEFFAAKFLALKAGGQIREKLLPLVTLETIQEKEYLLRFCCGMNQEAACAILEHINGLSEDLQTPAYLWIQSFSLVLVFEAQSPDLVKAVGSRLTLKYKEDFSAMVYFLQWLPDFVRLDRLNIHVTHIHAQAASRSILEQVRVDSLYFHLDLTSMNSGQFLNQLTALRENIASMPHQPHATRLYLTTDGCDNHSNTEECNTVGIQISQLSCFFRENQTLKNFGIGLAGNIIRSEVQLKDFVGTLVSCKATYLCIDDNDLHGSLGILSPLFQTLTSLVLRRCSLTDDDMNKVSRFVTEANNLTCLYFHGGNFSQDAVYTLIDAINQNESIDLEKLYLCDIDLDPSLVSRMVLEKIPHLKEFKTGFFAKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZER6</accession>
    <name>A0A8B7ZER6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Collagen alpha-1(X) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110986137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103482.1">
        <property type="nucleotide sequence ID" value="XM_022247790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZER6"/>
    <dbReference type="GeneID" id="110986137"/>
    <dbReference type="KEGG" id="aplc:110986137"/>
    <dbReference type="OMA" id="SWHRTSF"/>
    <dbReference type="OrthoDB" id="8964326at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034511312" evidence="5">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="142"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022103482.1"/>
        </source>
    </evidence>
    <sequence length="277" mass="27980" checksum="AFD307DECBD4E43A" modified="2022-01-19" version="1">MSVCFGIILSIAILLGNSFKLRAAITGPAPSDGDGPGSQACPMCCQQGPAGTPGIPGLPGSQGLYGPAGSKGDAGEPGLKGEMGPIGAVGERGAPGTPGSKGDDGMSLPGKIGPRGPPGLVGPTGESGVKGQKGEPGEIPENSNQRAAFTVKTRSSTPSDAPTGHTYRLPFQETETLLPGTSFDLETGTFTCNTPGTYVFMFSVCSVSSSGVTIHLWKNSNVVVTGASSDSSHHEQVSGSAVVVLQQGDSVYLTMHGRAHSSDNSHTSFSGFLLFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFC9</accession>
    <name>A0A8B7ZFC9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain-amino-acid aminotransferase-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110986622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104329.1">
        <property type="nucleotide sequence ID" value="XM_022248637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFC9"/>
    <dbReference type="GeneID" id="110986622"/>
    <dbReference type="KEGG" id="aplc:110986622"/>
    <dbReference type="OMA" id="THPKEIM"/>
    <dbReference type="OrthoDB" id="10047557at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022104329.1"/>
        </source>
    </evidence>
    <sequence length="299" mass="34108" checksum="8E1031B3CBB659E3" modified="2022-01-19" version="1">MAVWKKSPLHEQQVRLMMWTTPRSVSTAVTKCLSFVQDAQVLCEPFTAAHHVGPDSNFDHTGDTAEAALRETVPGVAETVGFDSSQCTYKWVKEQLEKAHTGKKFIFCKDMAYSVTGHFEFLPKDYKHLFLIRHPLKVFPSWKKVFQLNVGVPLDKYELDKLPEVLFPKNQGYKDMSDLMVYLKEADQEVIVIDTDDLLQDPRGILLALFNVIGLPFEENLLSWEAGNAIAQEWVISKEFLILNQEGHYYKTAFESKCFLKPSGMPNRASLSADLIRCVDAAMPYYKKLYTQRLTPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGJ0</accession>
    <name>A0A8B7ZGJ0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline O-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110986841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.6" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022104773.1">
        <property type="nucleotide sequence ID" value="XM_022249081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGJ0"/>
    <dbReference type="GeneID" id="110986841"/>
    <dbReference type="KEGG" id="aplc:110986841"/>
    <dbReference type="CTD" id="1103"/>
    <dbReference type="OMA" id="RYTCEYL"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004102">
        <property type="term" value="F:choline O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008292">
        <property type="term" value="P:acetylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF14">
        <property type="entry name" value="CHOLINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0530">Neurotransmitter biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="9">
        <location>
            <begin position="65"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022104773.1"/>
        </source>
    </evidence>
    <sequence length="674" mass="76432" checksum="AD30F8001CF2E0DE" modified="2022-01-19" version="1">MSSLVAITHCQSMPVTNGVATGNRRDAKQAPGGHMNHVTAERYVTNGDIDDDINNPIQLKPLPRLPVPPLHNTLAAYLQSLTATVSRTQYATTKSLVQEFAKPGGQGEYLHQKLLEYTETQTNWSNRWWLDDMYLNNHVPLPLNSNPGMVFPKQHFKDEGQRLRFAAKLISGILDYKVIIDARALPVDRVRHHKPGQPLCMEQYYRLFSSYRVPGEVKDSLVSPSSSVMPEPEHIIVACNNQFFVLDVIVNFKRLSEQDLLSQLKRIVDVSHQHPASHPVGLLTTMGRIEWAKARKRLIKDSTNRDSLDMIERCIFVLSLDANMGHPPAEVGKPMDADDEPLAHQMLHGGGTALNSGNRWFDKTMQFIIGDDGTCGLNYEHSPSEGVAVIQLVEHLLRYIDSETHKRKLTRAQSICELPCPRVLRWKLSDDTIQDIEKARTEVDRHVDDFDLKLLRYTKFGKGFPKSQNMSPDAFIQIALQFTYFRIYGHLTSTYESASTRRFLEGRVDNIRAATAEALEFSRSMIGDRPATELEKMDLLRAAIQRQTDICITNIMGQGFDCHLLGLRELSRELGEPMPEIFKDEAYRISNYFNLSTSQVLTKLDTFMCYGAVVPDGYGAAYNPHEDYILFAITSWKSCPTTSSEVFRDKLYKSLNDMHALCIRTSLNNNLIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGZ6</accession>
    <name>A0A8B7ZGZ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">COP9 signalosome complex subunit 7b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13" type="primary">LOC110986526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104145.1">
        <property type="nucleotide sequence ID" value="XM_022248453.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104146.1">
        <property type="nucleotide sequence ID" value="XM_022248454.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104147.1">
        <property type="nucleotide sequence ID" value="XM_022248455.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104148.1">
        <property type="nucleotide sequence ID" value="XM_022248456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGZ6"/>
    <dbReference type="GeneID" id="110986526"/>
    <dbReference type="KEGG" id="aplc:110986526"/>
    <dbReference type="OMA" id="GTYKQFR"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041481">
        <property type="entry name" value="CSN7_helixI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18392">
        <property type="entry name" value="CSN7a_helixI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="8"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022104145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022104146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022104147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022104148.1"/>
        </source>
    </evidence>
    <sequence length="288" mass="32134" checksum="88C09E2D1DF91D7F" modified="2022-01-19" version="1">MKTLQPPTRSIMDVNAQATPQVGSTHQPLEQYLLLAKSTKGAAVVALIKQVLEAPGVYVFGELLEMPNVQELANGPNSSYLAALNLFAYGTYQEYKENSNRFPQLSPVALNKLRHLTVVTLAAKSKHIPYPVLLKELDMKNVRELEDLIIETIYADVIRGKLDQKNQELEIDYAIGRDTKPEVVAEIVNVLQEWCDGCEAVLSNIEDQILRANKHREHCVKTKQQIEQEVASIKKAIKASSSSTTQDVEDQHMAADTREMEVQATKPVKKTSKIKGLRGSGKLWTKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHC2</accession>
    <name>A0A8B7ZHC2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Aminopeptidase</fullName>
            <ecNumber evidence="16">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110986598</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14 16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="16"/>
    <dbReference type="RefSeq" id="XP_022104275.1">
        <property type="nucleotide sequence ID" value="XM_022248583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHC2"/>
    <dbReference type="GeneID" id="110986598"/>
    <dbReference type="KEGG" id="aplc:110986598"/>
    <dbReference type="OMA" id="ATHYDIP"/>
    <dbReference type="OrthoDB" id="275509at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000012">
        <property type="entry name" value="Aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF301">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 16" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="19">
        <location>
            <begin position="53"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="17">
        <location>
            <begin position="287"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="18">
        <location>
            <begin position="596"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="15">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022104275.1"/>
        </source>
    </evidence>
    <sequence length="950" mass="109571" checksum="D1DB4DB3AF764F6E" modified="2022-01-19" version="1">MVVFTTFTVGILITATALMTYYIPLSLEANPTKAPVDPTIPLMRGRLPKTVLPRLYQLTLRPFLYDDDVADSKLGKRFTFDGLLTIRVECIEPTDEITLHAKDITFHASPTIHSVSSLDKTTDLFESYEIVEEYAFIVIKLKKIMDPHQEYSIYMEYSGILGDDEAGFYPSKYYDASNNTKYIATTQMEGPYARRVLPCFDEPSFKATYEVQLEHRTNMKALSNGLETGTETIDSRWSKTKFTTVHFMPTYLLAFIVHDYSSIQLTNTNGCLIRVWCPSHQISYADYALNISNLVQTYFDSYLDYEYPLAKEDHIAIQDFGAGAMENWGLITYQDFYLLHELDDSVSKTFYSLIITHELAHMWFGNLVTMEWWNDLWLNEGFATYMEHIGMNLVHPEFRRTETYYVNTVDRALKPDSLGTMPSVRAPVYANDKHISSQFSRITYQKGGSLLWMLEHLLTLDVFNAGIKSYLKERSYKNANAEHLWRQLTAADKDKGGLDIKKIMDTWTLQRGYPLVTLKRSTDGRVIEATQEIFLQLGENLEEEEFGDLGYKWWVPLTYLYKSGPSDKYDNPAMDWLDPSVEKTSIQLTGAPSTEWYLANAKMTGYYRVNYDETNWQRLLDQAAKDPNAFSEENKIGLLYDSESLAKAEIISMDIYKGFAQSFENNTLISQQAVLRTSSYFAKMLTRPSYGMKRRSLSNPSAAAQTYMQRLVEPLYVDSGWDENFMPDLPLARYETMDQFDITSTACQYGHEHCVSKATALFKEYVENPKQNTIPKNFRKVVYCNGIRFGDKVEWDFAFDMLQASDDRWERSRWISALACSADHSRLKRYLQSMLDTATYSRHDDALILMGVAQNPDGYEVAWEFVRNNWETVGKMFKRNNQLLRDVLEEITSNFNTNEKLQELLDFGEGRDLGAMKVAYDSAVVTTKVNIRWMANKAAETEQWIASRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHH5</accession>
    <name>A0A8B7ZHH5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Melatonin receptor type 1B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110986971</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105039.1">
        <property type="nucleotide sequence ID" value="XM_022249347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHH5"/>
    <dbReference type="GeneID" id="110986971"/>
    <dbReference type="KEGG" id="aplc:110986971"/>
    <dbReference type="OMA" id="WANIPEP"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="72"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105039.1"/>
        </source>
    </evidence>
    <sequence length="397" mass="44072" checksum="D470A6BC4199571E" modified="2022-01-19" version="1">MDVTTDMGTDKLTFNSTENPSLNFNDVGAGSLPTDNAAFNSTKNPPFEFSDYTQRVIVATLFLSVAVLGIFGNTLVILAVLLSRKVRTATNAFVVNLSVADLLTCLVIPWNAVALLGREGLPVGVWVCSVTAVVQNAAVGCSVFSLVFIGLNRLLLITRPRTTYYKIYTPKKIVVWLVLVWLIPLFITLLPSLMNIGGFTYNKKYHTCGSTTSQTSSHIYNIIVGGVVYPILLIIIIACYLLIWRHLKHHTKKMANAQQIEATPSIPSTISMGYTGSDDMKLSHVNQKSLKADNSQLGRRQSAITKNMFFVVCAFMLCVTPYAVVAMYGDSPARPYLFALFFFNSCVNPIIYGTKHRDFKAIFRYILRPQWANIPEPSGFFKVLRRSKCCWVSDQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIQ9</accession>
    <name>A0A8B7ZIQ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin-conjugating enzyme E2 U-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105523.1">
        <property type="nucleotide sequence ID" value="XM_022249831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIQ9"/>
    <dbReference type="GeneID" id="110987255"/>
    <dbReference type="KEGG" id="aplc:110987255"/>
    <dbReference type="CTD" id="148581"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23806">
        <property type="entry name" value="UBCc_UBE2U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="13"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105523.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38330" checksum="6AB10A8ECF942E44" modified="2022-01-19" version="1">MLPSFPRSKMHSRARMLLEKEYTLLQRDPAWGIEAEPLSDDNFFEWVATIQGLKDTIWEGGVFAINLRFDEHFNSVPPVVHFHTIPFHPNIDMNTGRPCVDFLDDYNTWKESYSLLSVLLAIQCLLSYPVLEAAVNPEACSILQESPDLYRQMVLDCVTASQRVHAGQSLQVEDAKVRFEEGEENQLADRPKSSQASQVKVSFDDYLTTWNGIATSKAEPNMRNPLLEAIKDDPKLQTAHFGLPLEELQQHMKKQLQEHNSLMYGNFAAKPNKADSQERKLDHINKMRKIYLPSRKIVPPPSTAQSDTGDPWEKEVDDLVEWTANLDEGELMEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKM2</accession>
    <name>A0A8B7ZKM2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="4">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022105592.1">
        <property type="nucleotide sequence ID" value="XM_022249900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKM2"/>
    <dbReference type="GeneID" id="110987298"/>
    <dbReference type="KEGG" id="aplc:110987298"/>
    <dbReference type="OMA" id="ITTDQSW"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000128">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="90"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105592.1"/>
        </source>
    </evidence>
    <sequence length="652" mass="73240" checksum="EB468A02C50EE17D" modified="2022-01-19" version="1">MKQAIETRYVSDSQVADPDYLDNFTRITTYCTRIAPADVTAQAHLREGTKVYMYQMTRTPTVSMYHVFFLGPKWLGVVHADRPAHRLRPTVRLREGWIIGETKPFNTDVDFLNVSTQVDIYKSIPYAEPPTGLNRFKPPIRKRAWDGVLSCLSFKPACMQTFPSLSGIDEDCLFVHVYVPHDLPDYADVMVFFHGGAYVFGSGSMPEYTGYPLASVGGVILVTVNYRLGPFGFMTTGNNDLPANVGLLDQLMALEWVRDNIKSFGGDPDKVTIFGESAGATSVGLHLLSKRSVGLFRRVIMQSGVPTTIFAYRRDVKEVIQETGLIAASVGCSNHTSSEMVLCMKSVPARELLIKAFQVTISFQPVVDGFFLRDRPETLLVNGDFPNKVDVLLGTLADEGATYALVVDMSAYNSATPPHMNRTKFLQAIPRYLVDADTSAVYQALDAVYANPDQLQDPDANYLENFVRITTDQSWIAPADWTAKAHLQAGSNVFMYYMTHRPTVSVMDVFNLGPGWMGAAHAEDLPYVFGNAWAEELFYKTKIPEDREKELAAKVMTYWANFAKTGDPNGPGLPAWPRYTMPDQRYKEISLDLGNGRGLRQNHCHFWNEYVPRLLTLFGPDEKTFTDYEYETKRWRESDMPAWMASLNALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZL37</accession>
    <name>A0A8B7ZL37_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987305</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105610.1">
        <property type="nucleotide sequence ID" value="XM_022249918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZL37"/>
    <dbReference type="GeneID" id="110987305"/>
    <dbReference type="KEGG" id="aplc:110987305"/>
    <dbReference type="OMA" id="DHACALE"/>
    <dbReference type="OrthoDB" id="10037886at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105610.1"/>
        </source>
    </evidence>
    <sequence length="467" mass="55040" checksum="8E61540B70961FB7" modified="2022-01-19" version="1">MSSRDWEYNLYTSQASEGKPPQGGRLTDDEDEDYDAEEPERMYHLDLSSRIKEKFHRRLVKTGIPRRPGFYQIQTSRSMAKPSGHFYSGKHWEMAPQSADKCDVRALQKPLERTTRRLTICAVNQACDFEQHRRMKNEAREMQQAGSLLSPLNKEFKRIIAFNEEEQQKEEMGKRQALMEDKDCVMAQLLYRDNAKNIQQAVEEERHRRMTIMSELTDEEKSSGDANFREMLRSLSKVSKLWQEIQDELSNAVHDLEEVHEEENHAIGDIFNELKDDFVLSFKRATLLMKFHMAEENERRHRVNEARLLSSGKKKLDPVQRRSSYMKDLTQQELVRVFNSVVMAENEKEEKEEVETDQHKMTAMEEMLRRHSIKEADHACALERVRRIQEAEDEVQPGARRDPLKERIKDMMVDVQEQMLLQIFRGHKVRHAEPRDIGYYAGESSQDRKLRTLRTQSRRKSCVVSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLV9</accession>
    <name>A0A8B7ZLV9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc transporter ZIP1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110987450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105880.1">
        <property type="nucleotide sequence ID" value="XM_022250188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLV9"/>
    <dbReference type="GeneID" id="110987450"/>
    <dbReference type="KEGG" id="aplc:110987450"/>
    <dbReference type="OMA" id="HEMSHTH"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022105880.1"/>
        </source>
    </evidence>
    <sequence length="392" mass="43130" checksum="9D3CB055CF914B90" modified="2022-01-19" version="1">MEIITLKITILCSLFVSCLIASLLPLKFVNIAIKRSGNEIRRNFIERVLRFLNCFGGGVFLATCLLDLLPDVEREFEAVLTELGMRTNFPVAKFVAALGLFLILSVEQIAYDIKERASRGQRERTEERDKKVDSDQKVDSDQKVDSDQKEDYQKANDKVHRLKYEESETTPLLIHHSTNKGGASHNSTSDEEGSINNEKLGQSMSFGHSHGTPIVGTDDRPLIQHTDTHDMVTSSSLRSLLLLLALSLHSLFEGLALGLQSDLNQLLAIFVAVLIHKTILALSLGINFVQSNLKPRTLIQSSVCFAIMAPIGIVVGILVNQGYSSTAHNITSGILQGLATGTFLYITFFEVLPMEMSQPGDRLLKVLSAVIGFGLIVSTLFLDPTITKPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMR1</accession>
    <name>A0A8B7ZMR1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Phosphatidylinositol 3-kinase catalytic subunit type 3</fullName>
            <ecNumber evidence="1 8">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110987621</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="1 8"/>
    <dbReference type="RefSeq" id="XP_022106180.1">
        <property type="nucleotide sequence ID" value="XM_022250488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMR1"/>
    <dbReference type="GeneID" id="110987621"/>
    <dbReference type="KEGG" id="aplc:110987621"/>
    <dbReference type="CTD" id="5289"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="13">
        <location>
            <begin position="36"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="11">
        <location>
            <begin position="609"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022106180.1"/>
        </source>
    </evidence>
    <sequence length="892" mass="101869" checksum="C88EDDAEDC50D789" modified="2022-01-19" version="1">MADEFDRFYYVYSCDLNASVQIKVGTLEGKRDRLSYKSLIDDPQLRFSGLYEDRCSDLCVTCQVFADGKPLTLPTSTSYKAFITRWNWNEWLTLPVKFNDLPRTAVLVFTIWDVYGPRKALKVGGTTVSLFGKHGTFRQGMHDLKVWPGVKGDGSVHTATPGKTDDSREQMSSLSKLTKKHHKGHMLKVDWLDRLTFREIEMINEREKRDSNFMYLMIEFPKVHYNGTHDFSIVHYDKDAEEKVIIKNYADIVTVPDPEMLMENLVEAKHHTLARSERSCLTDKDLKPNASTRDQLNSIVAYNPTKVLSSEEADLVWKFRFYLTNQKPALTKFLKCVNWDVPHEARQALELLRKWNPIDVADALELLSPQFKNPTVRKYAVSRLKEADDEELLLYLLQLVQALKYENFDDIKASQAPSTGQTVLSGYAESSVQKESSKGIHVLPHPLAESPDVPTSIAVQPAILSQDGHAKRKDEEMDLATFLIDRACHNYSLANYLYWYLLVESDDQDTVDTRVTQMYQMVLKRFNVALIREGNEGLKYRTLLIRQHGLTNQILKLMKQVARESSNRKKKIERLQLLLSDSESTSFSFVAFDPLPLPLHPEIKVNGTVAKKASIFKSALMPSKLTFKTVDGAEYTMICKSGDDLRQDQLILQMITLMDKLLRQENLDLKLTPYRVLATSSKSGLLQFIESIPVADVLSNEGNIQNFFRKCSPADNNAVYGISQDVMDTYVKSCAGYCVITYLLGVGDRHLDNLLLTKNGKLFHVDFGYILGRDPKPLPPPMKLSKEMVEGMGGASSEQYQDFRKLCYTAFLHLRRHSNLILNLFSLMVDANVPDIALEPDKTVKKLQDKFRLDLTDEEAVQYMQNLIDVSVGAVFAAVVEQFHKFAQYWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNW9</accession>
    <name>A0A8B7ZNW9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thymus-specific serine protease-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110987906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106757.1">
        <property type="nucleotide sequence ID" value="XM_022251065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNW9"/>
    <dbReference type="GeneID" id="110987906"/>
    <dbReference type="KEGG" id="aplc:110987906"/>
    <dbReference type="OMA" id="WIVIGES"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF11">
        <property type="entry name" value="THYMUS-SPECIFIC SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034209269" evidence="6">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022106757.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="56632" checksum="2928158A89728A7E" modified="2022-01-19" version="1">MKTTVLAVACVAIFFTHAQALSPYGFETSELHKRRLWNSVDVNDLHKYNLDAFPPAWSGYLTQPMDHFDPLVNKNFTQLYWIVDFYWKSNNHPVFLYLGGETQLTFDEVTHGHHAQMAKTHGALILGLEHRFYGYSFAQEGLLLPQLQYLSSQQQLADLSVFRGFAEKFLGMSGNNTWIVFGGGYAGALSAWYRLKYPHLVYGSVASSAPVRAQANFEEYNEVVANSFADPIVFGSAKCVASIRQAFGKIEQMRQAGKFDQLQNDFNTCQNLTKPNDFKTFANYLQSRFMGTAQYNRVEGNSSSIGDMCKIMMVPDPYQALVKMFKPSTCWDVSFDDFLEKLTNVYYHPYQVLRQWFYQTCTQFGYYQTCDNNTNCMFLPQVDVDYYLTWCAEAYNISAINVLEQVNFTNTYYGGDNPRGTRVLFVDGTIDPWYALSVLKDLPEDLKFIFINGTSHCEDMAPSNPNDTPALKAGRLAIEKVVSDWLIQAEMEKKHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQ62</accession>
    <name>A0A8B7ZQ62_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Centromere protein N-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110988392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-N/CHL4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107534.1">
        <property type="nucleotide sequence ID" value="XM_022251842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQ62"/>
    <dbReference type="GeneID" id="110988392"/>
    <dbReference type="KEGG" id="aplc:110988392"/>
    <dbReference type="CTD" id="55839"/>
    <dbReference type="OMA" id="CRYEDYV"/>
    <dbReference type="OrthoDB" id="6585699at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052011">
        <property type="entry name" value="CENP-NAC/CAD_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46790">
        <property type="entry name" value="CENTROMERE PROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46790:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022107534.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="41803" checksum="104A03507C80983D" modified="2022-01-19" version="1">MINANIEFSLRKVLGRFRRDEFVRNLKDWSFISSDSLREVETVVAQSKSSRKALVERVVQLTKVKKLTTHAVAQLDLIYQQNHPNNKKWSVFQLSKQQEYREKHVVTSPDAFQEQLGKQLSFYFKNDLCLRTKGDAWWVRLGIQEGSQSQRLSPSNVVYMVHHPHSQYIILSSIRVSHKDFVMQALLNSLHCSEIREIQLTGRDLDSLASLALHSNSQGWFSQFRLGQVDHNPLSKAPSRKRKASTDVSDSDIVFENQADKEQREQQILHAFGSNEQPKLQKIEYRLETRFRGSEFAPAMALRKEPFHCKVKFEGSSVLEGIKELGKVGLTSLPLPHHLGNVHSLAKNHFVLADKKRVRPEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQX4</accession>
    <name>A0A8B7ZQX4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110988361 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107467.1">
        <property type="nucleotide sequence ID" value="XM_022251775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQX4"/>
    <dbReference type="GeneID" id="110988361"/>
    <dbReference type="KEGG" id="aplc:110988361"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107467.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12206" checksum="453BAAF03D7CB212" modified="2022-01-19" version="1">MPSKQRMRSEREEDDGARSGRCVDSITGQSRIRCRRKSSSNEDLDDSDPDSDEEQEQWMEKPEAGVKSDHSVVGPLPLGSSSRISALVEQCDSIVVGLLPVGSSSDITALIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRD4</accession>
    <name>A0A8B7ZRD4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110988446 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110988446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107632.1">
        <property type="nucleotide sequence ID" value="XM_022251940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRD4"/>
    <dbReference type="GeneID" id="110988446"/>
    <dbReference type="KEGG" id="aplc:110988446"/>
    <dbReference type="OMA" id="ETYPNGH"/>
    <dbReference type="OrthoDB" id="10006218at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052001">
        <property type="entry name" value="MHC-II_Gamma/Thyroglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14093:SF21">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14093">
        <property type="entry name" value="HLA CLASS II GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033997155" evidence="4">
        <location>
            <begin position="20"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="5">
        <location>
            <begin position="88"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022107632.1"/>
        </source>
    </evidence>
    <sequence length="526" mass="58703" checksum="49B27D12563D0133" modified="2022-01-19" version="1">MSAGMRRVWFALLMGVCIGLMPSLVSYMRANSNSSNESVVRQVYRGSNEVASLYGRENVQAASRVQSLNKDISSDVGNPAEPRKILLDCGANVASTVQLFRETYPKGHEYTIHSFEIDDRLAPYFKPYRNHHLHCPVGVAGKDGNMTAYSEAAWGPDKGLNNGKDMQWGGGSLFVSNREKADAKTGGIRKLSYRKLIPTIDLARWIKDTFTVDDYVILKLDVEGAEYDILRNMVDHGAFKYIDKFYGEYHDSQPTGWSHADKSKLREDIKNLGFTMIDWIGERRTYTDFEGIHTVKVPADTPGTAGQIYSNCHDNQVAVIVAVGMNLKRAHKVVATLVGYRLALPITLFLYGDFVEQHPEVVKAWAGHFQIGIREDGPSPPGHLELMPWEWLRMGLVSAILQLEELGVAAAYYLPSVQGQDSLDSKFTNTASARGLRVIRPTVEFPAKSGSGVLTFDSYYKYRDVERVPKALRKIHEELAKTKGGILSLDTDLPDTYMNSVFLMDYLVENSGFKLVYLPECIASSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRU9</accession>
    <name>A0A8B7ZRU9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Snurportin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U transporter 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110988678</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snurportin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108124.1">
        <property type="nucleotide sequence ID" value="XM_022252432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRU9"/>
    <dbReference type="GeneID" id="110988678"/>
    <dbReference type="KEGG" id="aplc:110988678"/>
    <dbReference type="CTD" id="10073"/>
    <dbReference type="OMA" id="ENWIMVP"/>
    <dbReference type="OrthoDB" id="10003593at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09232">
        <property type="entry name" value="Snurportin-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017336">
        <property type="entry name" value="Snurportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024721">
        <property type="entry name" value="Snurportin-1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047857">
        <property type="entry name" value="Snurportin1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403:SF6">
        <property type="entry name" value="SNURPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403">
        <property type="entry name" value="SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11538">
        <property type="entry name" value="Snurportin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21974">
        <property type="entry name" value="SPN1_m3Gcap_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="13">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022108124.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38824" checksum="D563148611755C52" modified="2022-01-19" version="1">MDQLEEAFAGSLCVGMRVNDTATPHPRLSQFKQRGDKSSQDDRRRIKLESQKRDRLDYVNKARCLAEENWSNYEEQDEDEEDMDSGSSVLRKKRKPRYYRNQLMLSEWLVDVPTSLASDWLMVLCPEGKRNLIVAAKGKTSSYSKSGYRLSVFPSMLPGGCRKHKHNNTDYSLLDCIFQEATRTFYVLDIMCWRGHPVYDSDTEFRFYWLQTKLAEVPELAVQTSTNPYRFLALPSYPCNQSAIKDAMAKPAPFEAELDGLLFYHKEAHYSPGSTPLVGWLKPWMLPDMLGVPVPESVMASRPHGADLKPPAPSMETVVSANVDAEAGDSKSVAEGGNQMTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSL8</accession>
    <name>A0A8B7ZSL8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Collagen alpha-1(X) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110988920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022108573.1">
        <property type="nucleotide sequence ID" value="XM_022252881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSL8"/>
    <dbReference type="GeneID" id="110988920"/>
    <dbReference type="KEGG" id="aplc:110988920"/>
    <dbReference type="OMA" id="NDINEHY"/>
    <dbReference type="OrthoDB" id="6154955at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF52">
        <property type="entry name" value="C1Q DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034303711" evidence="6">
        <location>
            <begin position="18"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="154"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022108573.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="29597" checksum="11E56FB7DFC68D32" modified="2022-01-19" version="1">MFDSCVFIIFLLPPVSSQMRSKFTTPILFAYFLWVICRSSLAQTDEHSPSSSTGSCCGACYQGPAGAAGQPGIPGVPGQNGLPGSIGQKGEPGVGLLGPKGDTGNRGQKGNQGELGVQGLIGQPGKLGPTGPNGEKGEKGGKGEPGESTDVTPTPPSVVAFSAFLSGSFSGNSGDVIIFPTVTTNIGDAYDSGSGVFTCNVAGVYFFSVTLMSYNSGPTLFAILKKNGTRIFYVYDNHPNYHHQSSNSVVLMLAIGDTVLLENGRTNGRINGGIYSSYSGFLIQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZT22</accession>
    <name>A0A8B7ZT22_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Neurocalcin homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12 13 14 15" type="primary">LOC110988594</name>
    </gene>
    <organism evidence="8 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107972.1">
        <property type="nucleotide sequence ID" value="XM_022252280.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107973.1">
        <property type="nucleotide sequence ID" value="XM_022252281.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107975.1">
        <property type="nucleotide sequence ID" value="XM_022252283.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107976.1">
        <property type="nucleotide sequence ID" value="XM_022252284.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107977.1">
        <property type="nucleotide sequence ID" value="XM_022252285.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107978.1">
        <property type="nucleotide sequence ID" value="XM_022252286.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107979.1">
        <property type="nucleotide sequence ID" value="XM_022252287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZT22"/>
    <dbReference type="GeneID" id="110988594"/>
    <dbReference type="KEGG" id="aplc:110988594"/>
    <dbReference type="OMA" id="RQHTEFN"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022107972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022107973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022107976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022107977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022107978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022107979.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="22298" checksum="C1A97FCFBBDA190C" modified="2022-01-19" version="1">MGKQNSKLKPEVLQDLRQHTEFNESELQEWYKGFLKDCPSGHLSVAEFKKIYGNFFPYGDASKFAEHVFRTFDVNNDETIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRGEMLEIVEAIYKMVGTVMKMPEDESTPEKRTDKIFRQMDKNMDGKLSLSEFVEGAKSDPSIVRLLQCDPSGGGGSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU98</accession>
    <name>A0A8B7ZU98_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110988123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107071.1">
        <property type="nucleotide sequence ID" value="XM_022251379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZU98"/>
    <dbReference type="GeneID" id="110988123"/>
    <dbReference type="KEGG" id="aplc:110988123"/>
    <dbReference type="CTD" id="79691"/>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="6">
        <location>
            <begin position="41"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022107071.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="50349" checksum="FDC90305ED9AB923" modified="2022-01-19" version="1">MNQKRLSWVTRRKTKWRLSTDSEDCNIKMKFQLHKIQQAAGRLATLSELGRRGNVSMETPDCMLYTRCGSAPHLSHALLGGIDGVPAVTHIPLPTIVESVEILEAFGQGVAAFTGRPDAVVCTSTQDPRESTPTGYNDKNSVSVWASGGRRKLTVEGFLDLQEALQPDWMEALADGDTPVSSSTKRVKKSVDRTLEFLDQCLDAQRRRQQKLRDIDVFGVIEGGELLEERLRSACETAKRPVAGFVLDGFHEESMDDRARWGIMKAVLDEIPEDKPRCLPRVGRPDEVLDAVELGVDIFDSVFPYDVTERGCALVFSFMPVPSAQNDDIVSRPAPDGPVSGAVADRGGGTTCDLERQGGNGDLNGRTVYEMNLSDQRYVDDFTAVVVGCQCYCCINHTRAYINHLINAKELLARVLLMIHNFHHYFRFFRSIRKALQDGTLQELKAEINNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZW94</accession>
    <name>A0A8B7ZW94_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein FAM133-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM133 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109694.1">
        <property type="nucleotide sequence ID" value="XM_022254002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZW94"/>
    <dbReference type="GeneID" id="110989535"/>
    <dbReference type="KEGG" id="aplc:110989535"/>
    <dbReference type="OMA" id="KWVAYMN"/>
    <dbReference type="OrthoDB" id="10065679at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026766">
        <property type="entry name" value="Fam133"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31911:SF1">
        <property type="entry name" value="FAMILY WITH SEQUENCE SIMILARITY 133 MEMBER B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31911">
        <property type="entry name" value="PROTEIN FAM133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109694.1"/>
        </source>
    </evidence>
    <sequence length="184" mass="21577" checksum="8ED747FC08D9CA9E" modified="2022-01-19" version="1">MGKRDTRVAYINPIAAARAAGPIQQSGPSIRDYLSRPRPTWEEWKTMVSKKQGGSNTLAEWEKNMSDKFREDLKRDRERVLNKSKKKKKEKKRGKKRKRERSSSPSSSASSSSSSDSEQDSEAERREKRRKSKKTKKKRKRRHDYTSSDDESDKPSKSHSERRKKSKKHHKRKKRRDSDSSDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXT6</accession>
    <name>A0A8B7ZXT6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras-related protein Rab-40A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110989477</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109565.1">
        <property type="nucleotide sequence ID" value="XM_022253873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXT6"/>
    <dbReference type="GeneID" id="110989477"/>
    <dbReference type="KEGG" id="aplc:110989477"/>
    <dbReference type="OrthoDB" id="6339763at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022109565.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29860" checksum="4BF6402FD6AD7038" modified="2022-01-19" version="1">MNGSPAVRRNRTAYDYLLKFLLVGDSDVGKGEILGRLDDSANDITFGTYTSVNGVEHKITTILLDGKRVRLELWDTSGQGRFCTILRSYSRGAQGILLVYDITSRWSFDGIDRWIKEIDETNRSHSAVMIAVLRFKAETFDYHANSPLFQHTGWLELGLANDDTEGTKPAPPATPQTLIRYPQNLVCIHPLQASLPTAATLFLLALRNKQEALESEIDAVLQKQAISPVPMACGNKGFISMFFLTPEKEPCKFIHPKKIRMEMLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYX8</accession>
    <name>A0A8B7ZYX8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC110989913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110989913</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022110302.1">
        <property type="nucleotide sequence ID" value="XM_022254610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYX8"/>
    <dbReference type="GeneID" id="110989913"/>
    <dbReference type="KEGG" id="aplc:110989913"/>
    <dbReference type="OMA" id="LQINHEI"/>
    <dbReference type="OrthoDB" id="10363607at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="48"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022110302.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="70603" checksum="30D9C87A5AF93F4C" modified="2022-01-19" version="1">MSFTDQLTGSGTNQISTSDAPLPWVLPPGEVAFRVTLLLLICIVGVTSNALNGLMLLKSKRPGTTMHLLMFNLVVVDMTMTLACIPLSVFFTASNGDVHVPNELCKAAAYMLSTLIVASLLTQSAISVIRTLAIMLPEALQRRLPPATAYKIIAFVWLQSSLTTLMPFLSHDNVVDDLFTYEPRFMAYAISDDHTGKAQSILFSVIGYLLPLTIICISYVTLYVSLRRHLKKNFLTQDRQSRHMYTVQMKVQVKVGFLVVFVVSSTILIWVPLYIVSSLSLIDLAEFQSLSRNASAVLTFGTSSLNPVMYGFMNTSLRQEFKVYLAAKHPKLLALLGKMTCCRCCCKRKSKVDAVIVIPREQVQKSHGQGNRDVDEPVAISSHLVLQINHEISLKRQSVFSIKHPTDLTETSNVKHQHRDVMTGARGVTPPLLKRCSWSQSLAHNARRFSDKVSRRRSGSDSTTDCRRQLPLLDLQAVSRLREESRGLNNHDTRYPPKIHRDSDLESLCAQATNDPKAKYHMRTLSGQPLTPQKKQSFPGRKDGSVVAVSRCLKKQPVIGDIVKVRRVFIEEVTLVSGSYPDSVVDDGDQGVGHPQKSLSLRRESVSSADSQLVTSTTVKTSGDVYTTTTVQLPGCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZE9</accession>
    <name>A0A8B7ZZE9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110989118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108956.1">
        <property type="nucleotide sequence ID" value="XM_022253264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZE9"/>
    <dbReference type="GeneID" id="110989118"/>
    <dbReference type="KEGG" id="aplc:110989118"/>
    <dbReference type="OMA" id="NSTHAFA"/>
    <dbReference type="OrthoDB" id="6127264at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003884">
        <property type="entry name" value="FacI_MAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF14">
        <property type="entry name" value="BM-40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00057">
        <property type="entry name" value="FIMAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0768">Sushi</keyword>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="128"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="185"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="281"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="7">
        <location>
            <begin position="362"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022108956.1"/>
        </source>
    </evidence>
    <sequence length="570" mass="62576" checksum="C96DF0991E9ED64C" modified="2022-01-19" version="1">MISRCVDPLKEKLMTGALRMCNDGQWDGPVPRCESAAISFAIPSLYTMLHQFLANGTLLIYPRVGELTIQCIVSGGKSSLRASHSEGFTPIENGKRFGRPIESHSGIYTCLKAGSEDYHLLSIQVRAVSCGEPLPPLNGRRIGNEFHLSQTVSFECNEGYSLLGESQIKCNAGEWLGEIPRCKARACPEIHMEELDPNLRLKVDGGTSQGSVLAFSCILGFYSVGETFLTCQGGRWSHPFPTCQANDEDVLDTGPLLTPDTCNCEVWQRCVPSSYGQWTCNCINPRQCDDTTSQQQYCGSDGHTYASICRLKATACLLDLDIQVASQGPCPEKEVFTPGPHDCRCEVWEKCVVESVGQWTCKCIHPRQCEDVAGQQEYCGSDGRTYASICKLKATACIQERDIEIASNGSCAGENPEELSSYIESSYENSEYSVVTEDSHGASNATEDSASEDHVVYCRDCPNPDLRTVCENSTHAFAGVPTRVHSSPSGSLVYSLRVENGIKGLNHSNVTVSIQGTFNEVNQCHCPRITLRHDVYLFVWRQVDSTADFQISGGFVGLWSDNEGGYHEMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZY0</accession>
    <name>A0A8B7ZZY0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110990124 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110667.1">
        <property type="nucleotide sequence ID" value="XM_022254975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZY0"/>
    <dbReference type="GeneID" id="110990124"/>
    <dbReference type="KEGG" id="aplc:110990124"/>
    <dbReference type="OMA" id="MPNWASA"/>
    <dbReference type="OrthoDB" id="5967206at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617:SF3">
        <property type="entry name" value="CORE-BINDING (CB) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35617">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110667.1"/>
        </source>
    </evidence>
    <sequence length="303" mass="33576" checksum="C4824B29C41C12F7" modified="2022-01-19" version="1">MALVLSVGVEVVGHTLQTHHILQVALPVVVDNLEVGNLKVHVQLSLHLKPRLMPNWASAAEAKNRPRDGSDDCTMLAHPTVVPCLSEDADRATFTVTPNGQATDSQVQQQSSSTEKEVDSDSRSHIRKASRESALSERATPIILNAWKCGTHKQYSLYIQIWNAFCLQGQSDSISTSVNEVIDFLTQLFEGLRYSAINTARSALSQFVICKGGVTTGSHPWVIKFIREVYNLRPPVPRHHDTWDASVLLKYLRLLSPVAKLTLKMLTLKTVTLASLLVAARAQTLNVLDLTNMTKKHPNSPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0N6</accession>
    <name>A0A8B8A0N6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110990508</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110990508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111244.1">
        <property type="nucleotide sequence ID" value="XM_022255552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0N6"/>
    <dbReference type="GeneID" id="110990508"/>
    <dbReference type="KEGG" id="aplc:110990508"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034504871" evidence="7">
        <location>
            <begin position="16"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="136"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022111244.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="39508" checksum="04F91B94AC135D08" modified="2022-01-19" version="1">MKLLLLCLCVALAHARLAPLLTTNGRAVPDSWIVEVEDFDQLGRVQEEIEDIFSIFRAPAPKITKLEILMPVLMLKIPQHILTRVRAIEGVEYIHEDSILTLFGSQNNPPWGIDRIDSRSGRDGVFNYNDDAQGEGANIFIVDSGVNINHQAFGGRASLLFGEKDVGGHGTHCAGIAGADIYGIARKAKIYSCNVCSGGCWSNTIASALDYIVQKFGSGNGKGVVSMSLGGGYSNLMNTLVQRMLNRGYTVSVAAGNSNIDACNVSPAAVKGVLSVGATNSHDSRAYFSNHGPCIDLFAPGVGILSTAHSSDTGSMTLSGTSMACPHVTGAAAVYLGSNPGSSPRAVHYAIVNNATPDVVSDAKGSPNKLLYVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1D4</accession>
    <name>A0A8B8A1D4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">LOW QUALITY PROTEIN: muscarinic acetylcholine receptor DM1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110990222</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110795.1">
        <property type="nucleotide sequence ID" value="XM_022255103.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990222"/>
    <dbReference type="KEGG" id="aplc:110990222"/>
    <dbReference type="OMA" id="IASWHIN"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF120">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="104"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022110795.1"/>
        </source>
    </evidence>
    <sequence length="350" mass="40023" checksum="B72310FC499DC74E" modified="2022-01-19" version="1">MKLTKDGIHPDPAKVAAIVQMVPPTNKVEGVEYRRNCRHLLLIPDSEPVLEDQTPPDHINQQHPRPAMDRRHRTTKTPQWHQDYVITVTISVILGFISIVTIKGNILVIVAYIKDRCIRSTVANSFILSLSVCDLIVGAVSLPLASIWIVLGYWPFGKIPCQIWLAVDYTVVHVAVFTIIFISLDRYWLLTKKFAYATFQTHKRAASMIIASWHINLLFYSTSYQRKLPADTGLDDNAASVKGTRKRWTARQSSRPDQVDRGKRREFKRHRKAAVTLSVLVGVFIAMWLPFYMGSLLASICEECVSYLAWEVVNHLLWCNSTINPXLYAFLVVQFRRNFICCLKLKLCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3M3</accession>
    <name>A0A8B8A3M3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase TRAF7-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110990024</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110486.1">
        <property type="nucleotide sequence ID" value="XM_022254794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3M3"/>
    <dbReference type="GeneID" id="110990024"/>
    <dbReference type="KEGG" id="aplc:110990024"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF6">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="10">
        <location>
            <begin position="115"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="343"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="525"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="6">
        <location>
            <begin position="115"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022110486.1"/>
        </source>
    </evidence>
    <sequence length="617" mass="68819" checksum="3E8347CBB802551B" modified="2022-01-19" version="1">MATSVFAEEPSVHLFCPSCKRLLQDPVISVVCGHTFCRHCLTDGKDSVILDACPVDEKPLKNTSVVANRAITSQLDDILVYCKNGIKRFSSRNDELITDTCGCPELIRLSQKAEHEASCPYSSLQCPNSPECGTLLRLDLEEHVVTVCPFVKCHHYEKGCTFTGTSRAVEDHCLSCKYEASPCAVVNTVSQPSEDQVLLQKQVQMLIEKVLFLENSRDEMKAQLEACTRALTDVESKYNDLKATMDKHDAKLSSSSFSRSQRPHIRPRTASDRRDSSSPENTMTGHDHWQVPFEFKCIGTLRGHNAAIHCLATRGHRLYSSGLDKVIKVWDVDALSKGCVQNIKGHTDTVNALLAGSEYLYSAGEDQSIRMWKYDTMKEHKCVKKAHDSAICALVKNSKYLFSSGYCTIKVWHADTLEAVQSISGLHHWVRALTLEPSKEALYSGSHNVVCIWDATGQFNLKRKLEHQYGSVYALAITPKFIIVGTRGESGNEERSKDSLEGHSGTYNRNMQLFDVVTHQHVKCLGGHIGIVTDLATSPAGKFVISSSYDNTVQIWDLQNFLSLQVLSRHQGSVNAIALCHSLLFTASEDKEIKIFKYFRLITYSSFGNHILPGKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGM1</accession>
    <name>A0A8B7XGM1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC110973130</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110973130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079376.1">
        <property type="nucleotide sequence ID" value="XM_022223684.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022079385.1">
        <property type="nucleotide sequence ID" value="XM_022223693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XGM1"/>
    <dbReference type="GeneID" id="110973130"/>
    <dbReference type="KEGG" id="aplc:110973130"/>
    <dbReference type="OMA" id="CMGNYAG"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="75"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="641"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022079385.1"/>
        </source>
    </evidence>
    <sequence length="739" mass="82467" checksum="87346781CF0D2FFE" modified="2022-01-19" version="1">MLKSVYQGLANACSMVDCCFGLRPCHQAVFPCIRSCSYGDRKVFYNYDGTETVEPLVDYFKPTNTPVKRNMIRGMKLDKAELKQGLNPVQQIAAVVRFAQQNDLKVRAVGTGSSWSKLTNVRDVLIDMTDLNKILRVEKQTEDGSLYHIEVQGGMKLHDFVRVIDEDYGMSLPCMGNYAGQTIAGIISTSTHGTGQDYPTMSNFVAELHMIICGGIEVRIRIPREGETDEDFETVRQRVEAAKYGDPVLDIHSTDVFRAAAVGFGSLGVIYSVTLTCVPVYNIRETRHYVEMEWPESTAESRPVTQAPSRACSRSSLSAELPSSDTDSASGESIPTTSGTCQDQKSVFRIPETMKSMSAGQGKYFSFFVNPFPRRSRGDPQRTVLKSVYLSGERTDATGSCQCDCCLNFQCCACTGCRGQSACQIVQTDCSASCLQLGAHCLPSFIPWFADCGLHQFARDAPYIQKWYNVLTFTNGNLHIKTAEYCIPLEDLDAALADIIKVLQDYGKLYQTYTLLPIYVRMVKADDLYMSPANRHTADGGLCDRYCYIEVPFLPGAYGIDEFHKKLEDFLFTKYRARPHWSKNNFLSYNRVERLYPHLDRWRRVYTLFNRDGTFDNEFTRKCGFDDFHLLEGAEDKLREKGAEWSRRSDGEERSRSLERGSPTHDRPIAAPAQKDSGLGCRCSSGGGESTLAPDVIVTQPGPSSSSSSHSRLLDASEFTLEGTDVAPRSQPSEGDVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIX2</accession>
    <name>A0A8B7XIX2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Allatostatin-A receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110973556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080146.1">
        <property type="nucleotide sequence ID" value="XM_022224454.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7XIX2"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:neuropeptide Y receptor activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022080146.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38871" checksum="3B2365F96F83AD6B" modified="2022-01-19" version="1">MATVYWEWLTIIQLCLGILGIVGNLLVIVVYISKKKRQNTTNTLILALALTDLFTSINIIPWPTDWHGAVPLTALGRLYCGVIFPKFFMWTSIMASVGLLTILSVERYLAVCRPLWYRTVFSKTRPWHFIVAIWVFAAVEKSFNLYCTVPTPSGNCEFIVPGNGGFQIFLAVGVFTVEYMVPLLVMLVTYVKTIQALKRQARNLLEQIDSRNNPAFSLLQTRRKVIEMLLLVIVAFSICWGPLQFAFLIGSLGIKGDYFLSTLQDAFIVLAFFNSCANPIIYTFKNKSFRNSLRDRFRLRRKWNAVSSVTGTATEPGNKESHVQRTVRPVDRPLAIEDLPEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJM9</accession>
    <name>A0A8B7XJM9_ACAPL</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110973663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080342.1">
        <property type="nucleotide sequence ID" value="XM_022224650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJM9"/>
    <dbReference type="GeneID" id="110973663"/>
    <dbReference type="KEGG" id="aplc:110973663"/>
    <dbReference type="OMA" id="NNAHMER"/>
    <dbReference type="OrthoDB" id="166212at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
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    </dbReference>
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        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="561"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="318"/>
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        <location>
            <begin position="834"/>
            <end position="892"/>
        </location>
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        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
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            <begin position="118"/>
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            <begin position="260"/>
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            <begin position="273"/>
            <end position="288"/>
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            <begin position="370"/>
            <end position="379"/>
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            <begin position="765"/>
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            <begin position="853"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="1009" mass="112577" checksum="CCA35D979898494F" modified="2022-01-19" version="1">MNHLRVEERRPALAPEATRIIPPKNSFRMVEMTASVLSAELNNAHMERKTLEEALIEENEEAEEASGNGKQGGGILTPTQNKSGSLTRSTPAINRAGPTRERDKQILGGKQTPPLPSIPRSISRLSPVRSHPGSGVNEFPDSSLPAGPSLETKRAWKMQALERLATAGKKKPTAVLERSDSDVSSSSVFSLEDLKRRITERAKIAVVMVQRRARDNFSLQRQIHEKRNSVPPGPPDVYRGRRSRSRSLTPNRSAGDLVSQRRSSGSSDPLSLKTDRQHSGELIGRLDRSVSTSKSVGSLDSALPEKVTEDGAQPPASMPAGVELYERRRSVAASLLDVNGNLSYASRKSLRRGSYDGRLVEKTPRPARASDSSKGSQASAVAGDGKRPSLTPVAVSRQRGSAEVATLDSGDGFGAQLSRRRRSRAPASLAEDVSRFASKQTNPISCLKRFRLVAKVVVLCVSMCRKSFLRSEKEKEAYMSFESSSSFLGGQRLMFDPAYFKADRQQRLSEETKRILNLRPEARTDDLIKYVEIALRNIRAFAQYPKRMQHMLCRVGWLEEYESKRAILRQGHLPHAFYFILSGEVVVTVLDTKKGKRVAETVAMLKRGDSFGELAILNRTRRASTVISQDRVELLCISVEDFEDIFMLSGGIKRVNDPDQHAFLTSLACLKHWPLHLIEKHPNECRFHFFKDGNVLIKDSLFSDWIYIIKSGSCSVLKKLKRVSPSIPSRLKRKPSAVVWGNSTGHDALPSTAACTTEFVNSSPSKKKQRRHRRNHTWPVITRRPGGIRDGPTQTAADDAGLRSQPAGRASRGMADGFARRSLQGNCKRGVYLKTSRDESGVAASPNAGNKSHGTEQKSDDKNLEEESRPFVQRRREFHSDLDNSRTPVERTEADSDPMFVVVQVLTKGAVFGLTGVVFSDQPSLSLVSNGAECIVINKKFYLEHATEETLRGLRREEVPYPSEEELQSKLQQYMNWNAYRHHTFYTTLYESRDHKTERVTIMKPVLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJW6</accession>
    <name>A0A8B7XJW6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110974069 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081094.1">
        <property type="nucleotide sequence ID" value="XM_022225402.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974069"/>
    <dbReference type="KEGG" id="aplc:110974069"/>
    <dbReference type="OrthoDB" id="10069557at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF29">
        <property type="entry name" value="FI02030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Tudor" evidence="7">
        <location>
            <begin position="351"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="7">
        <location>
            <begin position="1044"/>
            <end position="1116"/>
        </location>
    </feature>
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        <location>
            <begin position="1314"/>
            <end position="1342"/>
        </location>
    </feature>
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        <location>
            <begin position="1433"/>
            <end position="1493"/>
        </location>
    </feature>
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        <location>
            <begin position="1314"/>
            <end position="1342"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="282"/>
        </location>
    </feature>
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        <location>
            <begin position="516"/>
            <end position="859"/>
        </location>
    </feature>
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        <location>
            <begin position="875"/>
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        </location>
    </feature>
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        <location>
            <begin position="943"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1579"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="714"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="832"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="846"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="950"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022081094.1"/>
        </source>
    </evidence>
    <sequence length="1601" mass="176250" checksum="F6E3117E1660F6D9" modified="2022-01-19" version="1">MASSKRKLMQLDKSIILEKINRIEEQEQWLFTSIKDISAGNVTEARKLLEETDRKKFWKHYVQVNSALEANLRTLMQLTINLKSSTNDHDDSDSSSSVDSQLDSIPGTNDDSTSVFSDVSTMTASSRGSISSRSRGLLSNKKSPTDKRHRPADPKGKAEAHCPSESVEDRGSASGKPSVTSVQEGQRVAGHKPDHQQQMQQDVQDSQRYAEREETRVPLGFHSQECASAGTESRTGPNKAGDSATGPELQKVPSNTEQTPRPPEQPASTQPSHPQTGSQQSVPLHCHITTKKQTAVIRPMAVKASPQVEMIVSEVNSPAIFWIQLADSQLDIFAQKLNRFYHDHQDLPIPAPEMRTFCCARFTEDDQWYRARIIGVRGQRSGQPPDLDDLAGIVVDVIYVDYGNCERLSLSRVRVLDPAFTQLPAQAVCCSLAKVKPPVPRSAWGKNQTDFFKTLVLGKKVQAAINLTKGRNVPSLDMSVPMVTCKTPSGDSHIIQVDVAEVMVRSEMALYVAGCGPPDVPLQPPQPPEGKTLPSTGTAGDRSSEGKGGGTKMSVKESGQHASSSGTSQLERSGDDKSLCSSAVKGAQGSNQKQQNQMPQEQKANESTSHQANAQTEDVPPGYFEYEEDKSNPFPRSRHQSSLSWRQVQHSNTQSTSRTEQLCRRQGNRDVPKQATPCPKSKPSEVPTAKASPPCLKRGSPPNRGQPDPPKRQGSWTGRGSRINSSRQAAAPPHNPRKTEQQQFQLEKRHLDSGTRGGPAHPPKSKEPVIGDSGSTKQRCSEKAVDEESQRVAGQKDASQEERSSSPEESGPGRISPNSSSGVSSCHSGQSNTSSTQRDATQCDSHNTDKPHRGRCWEESRKDVIESDVKDILGIHAEESGPQNCDFKTDDSIKQMDQARPVSEESLNKPLSASSRNLSSSVSSFVTAVTDLDTFQSDSSLAQYGKTDSRASSHSSSSSTMSRCMKTKKRDGAKSPLTLHPQLGQWNGLPVQDGCLKLEMSHIVSPLEFYVHLITPKAYMLDVLARDLNEWYNSEEGAWTEEPILEQGALCAAKFIEDGMWYRAKILHIGEEKAGTECPKDAKSNLMVKVLYIDFGNKEWLAADMLRPLRPAFYELPQQAIKCSLAHIEPPTKVDSWEIDAAKSEGNTQSRDGEAEVWPDNIAEELAKMTGYDKFLLGRITGDYDLHNDEPVQLILLDPSSLWEICINQELVNLGLASSSRFVPQPPPEDTSKPAEVTDRQLLMASECWSLKKYAEGGYDPVPEQSVEGQAEGNSQVVPTGQWDPLLSDFQSAHNSYHIDTDNPDVATGGHNVESIRQVCKFYSTGRVCYRGKQCPFDHVRRGERPHESMDVFLSDNKVRPPPAGSIVALEVTALHSAFHFWAQLPYSARPLDLLQQRGASPIDDEETLEMLEDAMNQLYSNWKHRQATNPPLRALGEMVCCLSPQDHRYYRARVIEVNTNLDTVQVFYVDYGNSEWVPAAEVHELQQQFLHLPLQAVECRLVGAKPLASNTEAGARLHEAARQCFEELVANKTLVALITYVTANGTLEVELHDTTGKSDVNIAEALIENELAERECQAPVTPNGGSSSEASSECYLLTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKL9</accession>
    <name>A0A8B7XKL9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ficolin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081353.1">
        <property type="nucleotide sequence ID" value="XM_022225661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKL9"/>
    <dbReference type="GeneID" id="110974202"/>
    <dbReference type="KEGG" id="aplc:110974202"/>
    <dbReference type="OMA" id="TINWSIT"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.530.10">
        <property type="entry name" value="Gamma-fibrinogen Carboxyl Terminal Fragment, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF327">
        <property type="entry name" value="FI21813P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022081353.1"/>
        </source>
    </evidence>
    <sequence length="224" mass="24442" checksum="64E25A186F0648AD" modified="2022-01-19" version="1">MAPEPTEPAANCQEILDAGVNTSGVYTIQHDGKTMQVYCNMESDAGYMEYAEGFGDLTGEFWLGSEKLHDLTSTGRCELIVTLRAFDGQNATVCYEDFKIESVDERYKLNVGSFHTVAGNAGDSLHGDQKFSTKDRGDDGSGSRNYAAMFHGGWWYKKYNGNNINSNLNGLYHSSPNVNDYQGIQWVSYKRRDYSLKGCEMKMSCGPKKGCGSGGSGSKSGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMS4</accession>
    <name>A0A8B7XMS4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">NCK-interacting protein with SH3 domain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9" type="primary">LOC110974258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081462.1">
        <property type="nucleotide sequence ID" value="XM_022225770.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081463.1">
        <property type="nucleotide sequence ID" value="XM_022225771.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081464.1">
        <property type="nucleotide sequence ID" value="XM_022225772.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081465.1">
        <property type="nucleotide sequence ID" value="XM_022225773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMS4"/>
    <dbReference type="GeneID" id="110974258"/>
    <dbReference type="KEGG" id="aplc:110974258"/>
    <dbReference type="OMA" id="CFARIFC"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="149"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022081462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022081463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022081464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022081465.1"/>
        </source>
    </evidence>
    <sequence length="621" mass="69648" checksum="669E159543D47BE0" modified="2022-01-19" version="1">MSYRALYKYRSSEPNALCFEEGDRFTLLDSSVDPHWWQVADVQGHVGFVPANYIEEVRGDKLDDVISSIDRAIEFIHLSGTEKGGTFTSEQRKTLQKLIEHRQTVLNTWQTKSADSSAKKQPPTRSTSRSSGKHRSAPPPPMRAGNAKPASTSPPATGPSQTAPPNGRVSLPASDSSDSERGHTKHEETVGSAIKVSSPVRSPSSPVPDKLGEELVEVVRVETGLSFTKCTMALSAAFSRVRDAVPSIAGPMDELLQSLQQMSNSSVSDGRVTLEGSKDKERLEVIFAELTDCKNDSQQRSWALHEDEAVITEYLEELIAILSDANPDVCKAVIQKDNYEIINSLVSYYQMEHRTSLRLLLLKTFGVLCGLESAILSQLLSSVLLVEIARDMQADANCLQKVYFSSLVATMLLSGGTPLPYTHYDQLNEEFVSYLLNNIEDPPPEDESEQVPDLFVNLVLAFNLHFTDRKANLVMKVLAERQTSRRFSEKIMILVNREVDPVRMFEYDPKPPNSLLKFLCDIFASADTSSLFYTNDMNVLIDIIVRQLTDRSPGDKLRTEYLSLIHSILKMAVYWENKHRLADLKRSLEKIAKEEEAESKPDKQILMDIRKECKFNFTITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ50</accession>
    <name>A0A8B7XQ50_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110974668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082166.1">
        <property type="nucleotide sequence ID" value="XM_022226474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ50"/>
    <dbReference type="GeneID" id="110974668"/>
    <dbReference type="KEGG" id="aplc:110974668"/>
    <dbReference type="OrthoDB" id="10233642at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022082166.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="37733" checksum="D142FF788D60BE36" modified="2022-01-19" version="1">MALVQTIATAVTSALILLQRRENLNVVEPTTSNSHQPSSEYLELYDNTSDQSQTDMHDYTTVSNVPVDLGLTLKSHSTKTKSMAQKINHGPPSVHPAPSNDDPSIAGYDDVVVQNNPKQVAPSDDDPSFSGYDDVVEKNFEQLAVDTEQDRSYVNKTIFAKRHIIQQNIKPVPQQNDGNFGEKRPGREKGQKSLGRVKPVSDPPVSTKDVHDYAEISSNLHPGPESAQANGGQESHSPVKPDRDTSIPTEYVYDYAEVPSVPNPCPALASQRGEVNRDKDPLVATEDVCDYEVPSARHRGPGTFSLVRAENITHGQGPSNDGGYQALDPVGLGRANTYTALSLKNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XS30</accession>
    <name>A0A8B7XS30_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Multidrug resistance protein 1A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110975142</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082997.1">
        <property type="nucleotide sequence ID" value="XM_022227305.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975142"/>
    <dbReference type="KEGG" id="aplc:110975142"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000018">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000046">
        <property type="entry name" value="ATP-binding cassette subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000479">
        <property type="entry name" value="Multidrug resistance protein 1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="867"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="948"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="974"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1054"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1086"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="133"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="468"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="16">
        <location>
            <begin position="825"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1150"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="707"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022082997.1"/>
        </source>
    </evidence>
    <sequence length="1393" mass="151838" checksum="5763A5BC27BE916B" modified="2022-01-19" version="1">MCRTVILLSPSQYTELSQIMSTRTIEVKAADPQDMTAEEPQTWAANNAAPPSEPPPPYNSVEVDFATASNGKTAAAPLKMGKVAENGNSPKRKGSQEGEGKEKKEKKEEIKPVSIIRLYRFASALDILITLCAVGFSIAQGVSFPLLLLYFGDITDAFIGSGNLGGSLPANTTVPPGFYEDQFLNEIVRFCAIYAILGGAMMVVAYFSHSLWNTTASRQMFKIRQRFFAAILRQEIGWFDTHESGELNTRLSDDVQKIKDGIGDKVGQTLYLLTVFVAGLVLGFVKSWKLTLVILAISPLVILSAGIMTKVLQSFSQKELDSYAKAGAIAEEVLSSIRTVVAFGGQEKEVDRYSVRLSEAKNQGIKRNTAQAAGIGIVYLVMFGAYGLAFWYGTTLFLSAELEPGDILVVFFSVLFGAFSLGQAGPNIGNISQARGAAAAVWKIIDQVPSIDSSSEKGLKPDSLTGDISFESVHFFYPSRPEVKVLNGLDLEVKRGQTVALVGSSGCGKSTTIQLIQRFYDAAQGTVRIDGNDIKDLNVKWLRQHTGVVSQEPILFGCSIEENIRYGRMDVTMEEIMTAAKEANAHDFISALPQGYETLVGERGAQLSGGQKQRVAIARALVRNPKILLLDEATSALDTESEGTVQAALDKAQSGRTTVVIAHRLSTIRNADVICAFKDGLVVERGTHAELMALEGGVYQQLVYMQSRKEEKPEEGEKSEDDLDDDDKEEEEEIKKETPKKSGVVINDKREKDVEGAALMDSARADTPGTPHARTSSFKGLKRMASTVSTHSKEGEEEEDEKEVLKAFSAGRIMKLNAPEWFYILVGSIAAGINGAVQPAFAVVFSRILEVYSLDKVTQLDEINRRTTLYCLLFAGLGIVTMAASLVQGAALGKSGEELTIRLRHMAFKAMLRQEIGWFDDKKNSTGALTTRLATEASQVQGATGARIGVMMQSICNIGVAIIIAFIYGWQLTLLVLAFLPFIAIAGAIEWQLVQSSSQQDKDALEISGKIATEAIENIRTVASLTREETFYKNYVSLLVGPHKTNMKRAQASGLAYGLSQGIIFFAYAAAFRLGGHLVLIGEMEFQNVFLVFSAIIFGGFALGGATALAPDYSKAKFACANMFRLMDREPLIDAYSTEGDTLDHYNPEVAFEDVRFRYPTRLDVPVLRGLTVSVKPGETLALVGSSGCGKSTSIQLLEKFYNPRSGTVLLDGHGLDTLNLQWLRAQIGLVSQEPVLFDRTIADNIAYGDNSREVPMTEVIEAAKKSNIHEFIASLPAGYETKVGEKGTQLSGGQKQRVAIARALVRNPKILLLDEATSALDTESEKVVQAALDEAKKGRTCITIAHRLSTIHDAEKIVVIRHGKVAEMGRHEDLMQLQGQYHSLYTKQDLQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XT06</accession>
    <name>A0A8B7XT06_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083993.1">
        <property type="nucleotide sequence ID" value="XM_022228301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XT06"/>
    <dbReference type="GeneID" id="110975651"/>
    <dbReference type="KEGG" id="aplc:110975651"/>
    <dbReference type="OMA" id="DFPMPMR"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391">
        <property type="entry name" value="RETINOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43391:SF86">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083993.1"/>
        </source>
    </evidence>
    <sequence length="283" mass="31441" checksum="9DC2E7E9C170CF75" modified="2022-01-19" version="1">MAPKVVLITGCSSGIGLATAVCLAKEKQHEFKVYATMRNLGSMSRLEVAARNALDKTLFIRKLDVTKEDTISSVVDEILRENGRIDVLINNAGYSGVDGNDEWPIERCQAMMDTNYWGVVRTTRAVLPAMKKQKSGRILNVTSVAGIIGTPFYATYASSKFAVEGFTESIAPVLRDAYNIRMSIIQPGPVRTELMVKIRADPEGDAKDFDSVTRDMYLARRKQLRPLMDQVEQTAEDIAKLHLEVILSENPHLRYQTSEATTQFVAAKLKDPTTDALLNVLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUZ9</accession>
    <name>A0A8B7XUZ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Src kinase-associated phosphoprotein 2-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110976045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKAP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084683.1">
        <property type="nucleotide sequence ID" value="XM_022228991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUZ9"/>
    <dbReference type="GeneID" id="110976045"/>
    <dbReference type="KEGG" id="aplc:110976045"/>
    <dbReference type="OMA" id="ASDRCDK"/>
    <dbReference type="OrthoDB" id="243840at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000734">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037781">
        <property type="entry name" value="SKAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129">
        <property type="entry name" value="SRC-ASSOCIATED ADAPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="145"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="458"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022084683.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58332" checksum="ECAEB86E4E42C6FF" modified="2022-01-19" version="1">MPELEHVIEEVKRFLKDVETYLSVTLKKEKLKRETNAKREELLKDAASLIGKLSPHEIEEEEQEEYADVDLPTSASADKTQEEDEDECDDIYEDTVPESTHSNDSSQISEDEGEEPEERSGMFDLDGDPYGDVKVDPIAASDLTSPSKEGYLDKKRKEGQFGLQSWQKRYCIIKGNILYYYKKKTDKEQCNQIVLTGYQGREAPEFERKNKRKDLLFEVVCPAKRSYQFIAQNKKDLQEWIKAISVASKLGPSSVDPLAKSTPNNSGGSEDLSEEYDDTSAPGPSCEVNDDDYGDTYEDLDAYQATKMGGPVAPVAEPPAGAGENEEDVEPIDEEIYEDVPQAELPPPAPMPERIPKPSAANKPLPPEPPQSESPPPIPTSHRPVPPPSVPIDTQPARPYSPHMHIKTYPGKNIKNVAKPALGMSKPAIASTPAPPVPSRAANEIADLPIRKEPWEEDYANIYIGLWDCMADDQDELEFRRGEMVHIISKEYDTFSWWIGERNNKVGLVPKDYLMKAYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVH8</accession>
    <name>A0A8B7XVH8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110975661</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084020.1">
        <property type="nucleotide sequence ID" value="XM_022228328.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975661"/>
    <dbReference type="KEGG" id="aplc:110975661"/>
    <dbReference type="OMA" id="KEIRILX"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003539">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022084020.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="20253" checksum="3A29425CA9C4FDE8" modified="2022-01-19" version="1">MGAFASLFKGLFSKKEIRILXVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFLNTQGLIFVVDSNDRERIGEVRDELTTMLNEDELRNAHVLIFANKQDLPNAMTAQEITDKLNLQGLRGRQWFIQATCATSGDGLYNGLDWLSQSLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVT2</accession>
    <name>A0A8B7XVT2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Basic leucine zipper and W2 domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110975632</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BZW family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083946.1">
        <property type="nucleotide sequence ID" value="XM_022228254.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083956.1">
        <property type="nucleotide sequence ID" value="XM_022228264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVT2"/>
    <dbReference type="GeneID" id="110975632"/>
    <dbReference type="KEGG" id="aplc:110975632"/>
    <dbReference type="OMA" id="ELIQCIW"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11560">
        <property type="entry name" value="W2_eIF5C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000006">
        <property type="entry name" value="Basic leucine zipper and W2 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043510">
        <property type="entry name" value="W2_5MP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="3">
        <location>
            <begin position="257"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022083946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083956.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="48955" checksum="7D54EDB547D4B89D" modified="2022-01-19" version="1">MSNKQPKPVLTGQRIRTRKRDEKEKYDPNGFRDILVNGLNDINVSNLDEVTKYLDGAGSKLDYKRYWETLFDILLAGGILAPGGSLLQDDDKKETTISKFCLFSAEETTEAIKGVAMVFQRLTRRYRYLGKKLEDDEMKKILSFLKTFSQSERNKLAIFTGLFLCTGDNPAKCLESLYTETLVKEGISLEFFKVMFHTWLGEKDMSSIANVLRKASMDRRLLEVIPSTKRSEEYFEKCFNEAGLDQLVTFQRNMLHDDNKNSFMTELKELMEKENPPTAKELVGICSEMKTKTLLSEPEVVKLIWNCIMDIVEWNKKEELITDQALRHIKPYAPLLAGFTSQASTELTLLYEIQDYCYTNISFMKTFQKIVVLLYKTDVLSEETILKWNKEIHVGKGKSVFLNHLQQFVEWLENAEEESDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XW71</accession>
    <name>A0A8B7XW71_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110975697</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022084091.1">
        <property type="nucleotide sequence ID" value="XM_022228399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XW71"/>
    <dbReference type="GeneID" id="110975697"/>
    <dbReference type="KEGG" id="aplc:110975697"/>
    <dbReference type="CTD" id="60625"/>
    <dbReference type="OMA" id="FHEVMET"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17980">
        <property type="entry name" value="DEXHc_DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000007">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="62"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="251"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022084091.1"/>
        </source>
    </evidence>
    <sequence length="701" mass="79027" checksum="EFC3F34049F92486" modified="2022-01-19" version="1">MASFAPKFWKPGTDKPGAGLKEERSQISEGSGECAVYNPYVAISIEQQRQRLPVFKHRNHILYLLEKYKTVVIVGETGCGKSTQIPQYLVEAGWAAEGRTVGVTQPRRVAAVTVAQRVAEERGAVIGHEVGYSIRFEDCTDPDTTKIKFMTDGYLVREMMNDPLLSKYSVIMLDEAHERTLYTDIAVGLLKKIQRRRPEMRIIVASATLDAEAFRDFFNQNETDDASQDTAGILTVEGRTFPVDIFYSINPVPDYLKATAETIMKLHKAEPAGDILAFVTGQEEVERVMEMVLQEIRSLQFDHMKMLALPMYAGLPGKEQMRVFERVGRNTRKVVIATNIAETSITINGIVYVIDSGFVKLRAYNSKPGLSGLVVVPVSQASAQQRAGRAGRVRSGQAYRLYTEEDYQALRKTTVPEMQRSDLSAVILQLKCLGIDNVLRFSFLSPPSSRAMLRGLDLLYALGGIDDHAKLAQPLGIRMAEFPLDPMFAKMLLVSGEFGCSEEILSIAAMQQIQNIFQSPSNEKGKAERAKRKFSVAEGDHITLLNVYEAFIKSGKNSRWCHENYLNYKGLCRALTVREQLRKLLKKFKVKMVSSEGDVDTIVRCVVAGFFANAARFHPTGEYRTIRDDHAIHIHPTSVLYTEKPPQWVVFHEVLQTNRDYMRDVTVIDPTWLYELAPHYYQYGTDMEIAAKRARVEDMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYP2</accession>
    <name>A0A8B7XYP2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar fusion protein MON1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110976152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in membrane trafficking through the secretory apparatus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084896.1">
        <property type="nucleotide sequence ID" value="XM_022229204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYP2"/>
    <dbReference type="GeneID" id="110976152"/>
    <dbReference type="KEGG" id="aplc:110976152"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="4">
        <location>
            <begin position="168"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="5">
        <location>
            <begin position="328"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 third Longin" evidence="6">
        <location>
            <begin position="455"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022084896.1"/>
        </source>
    </evidence>
    <sequence length="566" mass="64158" checksum="BDD712139DEE51B8" modified="2022-01-19" version="1">MVDLFPFPNVCFHCAKSPVQYLAYAHGGECHCHSVCECVHPMLATEDSYEELDYDLSIEAPTEDQRRERLASGTIASIVEEHTGSGSVEEVATEATELENDVGGRRAEGNTSNLQTAEDATQHRTDTVAERKDVPNDTNEEVRQTREAEQREIADEDIHSSVWRDHKKHVFILSEAGKPIYSRYGNEDKLVSLMGVMQALVSFVQDGKNVLRSIVAGGRMFVFLVRQPLILVAVSRTYESQQQLLMQLTYVYNQVLSVLTYSQLSRVLETRKNYDLRRLLAGTEKFLDNLLNLIDQDPSFLLTAVRCLPLDSATRDTIGHSIQSAKIKDLVFAILIADNQLVTLCRMKKYILHPSDLHLVFNLLNASTSFQAADSWIPICLPKFDSDGFLHAHISYLDNSKACLLLLTVDKMMFFELAKCKDKIVDKLKKHNCLEAINKAVAGGGYRCQEVGISDLRHFIYKSKSTAQFTAPELEAPYRDPEERARLFTIYQYVHQRVHNAARPLKIMFHVGSREAMLGWVTTGFELYAVFGPLATKQVAILAVNKLLKWIKKEEYRLFILDPPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZ65</accession>
    <name>A0A8B7XZ65_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110976861</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110976861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086198.1">
        <property type="nucleotide sequence ID" value="XM_022230506.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976861"/>
    <dbReference type="KEGG" id="aplc:110976861"/>
    <dbReference type="OMA" id="WETVGGH"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14365">
        <property type="entry name" value="CUE_N4BP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041801">
        <property type="entry name" value="N4BP2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="1531"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="2335"/>
            <end position="2421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1484"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1702"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2239"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1283"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1484"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1498"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1605"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1708"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1732"/>
            <end position="1747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2252"/>
            <end position="2262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086198.1"/>
        </source>
    </evidence>
    <sequence length="2421" mass="266354" checksum="4E37047658EE0E48" modified="2022-01-19" version="1">MPNKKKGKPSGDSETGGGWTSVKRRAHHHASHKGATAGGDGRCIATEDADSSEEARTKELRYLQEMFSGKLDPVVVHMIMNDCDFKVETALETLFELAEQTSPVESQMYRLSGFKDVYIPRVDAEEEPDEDDEHGEGEDVDVEDPPFPDNYGVRRSPSTLPRSGGDDDPAQSPPRNPGLSTQAEGAKDEGGKMSSSKADSLSDLPLKWGGLEPSRAFQPRFPPKQNPFARHPRERPISPLNNLSKIDPSDSTLCYTDKEASGQRNISEFGHGSATESLITNTSSHKMNIHEVRDTGAGTCSTLSDESKNDEKFAHKGAFTSQHGPTDALLLSDNLETDRIEPAVAASQTPMSVEQNFGRDPTPSSEEKLKDESPAEEAVSGSSPADLPAGELEALLGEIEMCPEKLSESEENVEPSITDHQLGLANEASVDCTDLLEKTSSPAELKPETNFSQIDKANEVPTIKYVKPKHQSTTVQKDDASKNDKQRSMNVAAPAFVPRVYARPLTPTGHQQYPPPKGFKPRQGLWMPKVPHPAGRASSLQKHLKQFDGQVGRPFFTPSPGSREQSPNLLEESERQGWNASQQQQPFQHPAQMFQPPESRFRPVSKRQPQASFWLQNQPPHPRHRMPSGPNQSYQLFGPGVVPPSHDAPLVGTTPSRGQRTNSPHEGARQPQGPSQRPVNKHMSHAPREQGYNCKKAGMEGKAVPLPEGKVLCLMRGCPGSGKSTLARTLVGNGQILSTDDYFTREDGQYCFDITKLSEAHDWSHQRAKEAMESGVTPLVIDNTNIERWTMKPYVAMAVRYGYAVEFREPTTPWKFNLGKLFKYNSHGVPRERIKLMIERFERDVNVENILGSSKPEKPKRKMTEAEQHPSKESWRKTKKKGTTAHKEDSTSKQDLAPGSHKAKAQDKDDTAADKNQEECDDVTVATDAITEKSQNRAELFMSEDEDGFDALMDSVACDSAEDVIARCDEDKMNKKPQENVGDEMMVSLNKESSCETVATAAAKSCDEKVNDSRMVDAEEELEMTMRTSEAPLELLEPFIIEGTVHQVLSDSTGDGENEEDDDFLTMVNAMKEASCHLPLAVISSLEESENLQGEQQEQQPTSSPGFLAARTKCDSHAMLSHPPGFELLSKLPDESPEGKQGSYSADSDEDDFAVMMNLIADASCQEQDQPVPICRNEARNDENVPNLHCIPSVSTNEPSAFTQHLKTNADLHNADAAGEFADSPFEKQGSVKTGEDNGGKGKADECCSDTKEANKVGQVSAAIANENVSLEKDALKRKSETDQVVVSTDDQQSNHMLNDNCGSGMSDFKPPIASDLRALSSVKENKTHVQTDEVPSTTQPTSPSDLLVPSSECRGLSPSLLGPSAASEDGVTKQCQERRKVRRSRSLNKNTKMAAVFPTLSPGSENWSDLAGLVDLGSEDKAGLSRNKSPVLESISFTEAGTETLPSDFSCVQRMESGELTVEDLRLQGLFVAVAQARQIALRESDVTSQREDAISERPLSSSSTSHSPVPATVRLHKSTMTDHEESTENINDNLKNLITLFPAVSPKDLEDILARCKGDLEWATNILLDDFGNRERIDPESQELNTSDQLSGRSQTENSSRPVKAEFNDKESQVNGDNQTKVAADCMKDHLEAKQVSQAENLATNMISVVDDILKAIGSKDTLASVDNTPLKQTSERGKTEIDAVDNSNHFKCVLESNSSPVSQVNLNSSNLESASSCPDSDTKVKSDISPPSQEPASNQSSSESEGAPRMANFLQKQKQTVSDSCLPGEEPKLDREDLSLRIGMSHGVDLSEVEVAAWIREARTESNILGSSTSHEASIYPSTGDQQQVGLVDCSNSASALPGMAYSRGSGLTASDPFTDYGTPTRENKPQVVRPKTPLRTALSQSPTKASKVKKPKDVDLFVKTTHSVEAEAPLRSCELEAAGGVRFSWNSGREIEEFGVPHEGQMMTGQHDGFEMEEGSLVTEEQEDATLHDQPVQKKLWELRSLEEGLILQLPPAFALQLQEMFGSIGFHLLPELLPAEDLQVHVDYDLAKTLHTLWAQTLQTRFDKEEELDSIIQADEELARKLQQEEDIQHMTEVQSARSAKYQGTKAPLKAAKPPISLRHGYGDSKGMMGALTTTRQPPAMEEVKGLKEIMEEELAAQLSKDMEVESKLKTDDSVSIATKLKRDKLFSEFPTLDRDVLEEIFRDYNYQLDPTIRHIKSFFNTASSQPKNVYTDEALERIEKELIGVAERQSLASSEDTDESNPQEAFQSTENPDYQDYRGEATMHYRLRHEAFQKAAAAYNRGQKELASFYSQQGHLHTEKLKAANKRASEAILSSKNALFNDNTLDLHGLHVDEALLILKQVLSDKEAELAAHDQLPRPSKSPQKYIFVITGKGNRSRGGVARIRPAVTELLKQEGYRFSMPNAGLIKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0Y9</accession>
    <name>A0A8B7Y0Y9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C-Jun-amino-terminal kinase-interacting protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">JNK-associated leucine-zipper protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Mitogen-activated protein kinase 8-interacting protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Sperm-associated antigen 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110976856</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JIP scaffold family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086192.1">
        <property type="nucleotide sequence ID" value="XM_022230500.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110976856"/>
    <dbReference type="KEGG" id="aplc:110976856"/>
    <dbReference type="OMA" id="NDNITAC"/>
    <dbReference type="OrthoDB" id="10256043at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008432">
        <property type="term" value="F:JUN kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030159">
        <property type="term" value="F:signaling receptor complex adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1770:FF:000001">
        <property type="entry name" value="C-Jun-amino-terminal kinase-interacting protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1000:FF:000001">
        <property type="entry name" value="C-Jun-amino-terminal kinase-interacting protein 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000700">
        <property type="entry name" value="Sperm-associated antigen 9a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039911">
        <property type="entry name" value="JIP3/JIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032486">
        <property type="entry name" value="JIP_LZII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886:SF4">
        <property type="entry name" value="JNK-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13886">
        <property type="entry name" value="JNK/SAPK-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16471">
        <property type="entry name" value="JIP_LZII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19056">
        <property type="entry name" value="WD40_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RH1" evidence="17">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="18">
        <location>
            <begin position="493"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="837"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="905"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1289"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="60"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="427"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="848"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1301"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022086192.1"/>
        </source>
    </evidence>
    <sequence length="1334" mass="147793" checksum="564470FD65DFE57A" modified="2022-01-19" version="1">MMEDETVYGTADDGGVSVMSERVQSLASSIYREFERMIKGYDEDVVKELMPLVVNVLENLDGTVAENKDYEVELELLKDDNEQLITQYEREKQLRKQAEQKFLEYEDANDQEKRALQARVEALELAQKQATLKVKNYSDQVARHEYRESEMKQEYMILQKRHNEVLQKYMEHVERLKMVGQPDTVGSPRLFKLNLNRPHSPILMEQDMVGVPNDTRLADALHSPTTPPKNFVPSEQPNDSNLHHEIMTSPDRETLDGKKVKKTPQKHIETQAGVDTSNAATVTSPQKDNRTMSPELAAIVDSTPELQGKKTERPTNISDSKGESKENATIFEELDPALISEMDEGASITAVEDYLLNQFKLSTDSMHAFEKAVDPSEFSDDSEESDVSYGLDVMSPDNFYGMGKEVENILLENSELRATKNALNVVKDDLIAKVDELMSEIEVQRQEMNGLQTTKGRLNLRITELEEEIKKLKEENDKVASVDEEEGVPMAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTXXCRASREHPSFEGKKNKSSIWKFFSNLFSTTPAAPQRKPGYPHANIRYNAPTSSVTPSAKQRTQTIASLDNRTKAFEFLEDGDPRLNKDKREQYKKVKAHVRQDDGRVQAYGWSLPAKLPSPPRGPTQQTGSMVGVPVPVFCRPLAEKELGTKIWCAAGVNLTGGRTRDGGSIVGASVFYSNSAPEDSAQLRKERSDSELDRLDEEITKQQKAICDSGKNQLSSLVWIGTTAHDASKVTVIDANQPQVLLDSFPVKNPHILCIASVPGAMESDYPSEDIEAADDTASVNSVTSNGSDSGFGNITLVTVSVPVTPRSSTPNSEKGDTNHGEEGTEFKAEVGDAKFSNIASVEDAEQSITKAATTAPLADTVGMEGIVREDHFGRGNSTSSADSEHSGDPLGVTSDPIPLEIMRHRSSTTGASDLLKDGLSSAPTENDVMHEEFEKMTSIKPTMWLGAQDGCLYVHSAVSQWRRCLHSIKLKDSILSIVHTKGRVLAALANGTIAVFHRSADGQWDLSNYHILDLGRPQYSIRCMVLVYDRIWCGLRNKVHVIHPQTLKVERSFDAHPRKESQVRQVAWQGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMIACNRLWVGTGNGVIISIPLTETTKPTPTGGSRPGGVIRVYSDSKSDNVRPGNIIPFCSITQAQLSFHGHRDAVKFFVAVPEPSLPSGTAGGVSASSSSSSLDVAQSKPATDRAAIKNMLVMSGGEGYIDFRAGDGDEEDESAASNNYGDDLTNSSRAARNERSHLIVWQVSGVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1J6</accession>
    <name>A0A8B7Y1J6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110976849</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110976849</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086178.1">
        <property type="nucleotide sequence ID" value="XM_022230486.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_022230488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1J6"/>
    <dbReference type="GeneID" id="110976849"/>
    <dbReference type="KEGG" id="aplc:110976849"/>
    <dbReference type="OMA" id="WNNGRRD"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Death"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEATH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016729">
        <property type="entry name" value="FADD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15077:SF12">
        <property type="entry name" value="DEATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15077">
        <property type="entry name" value="FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="32"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="142"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086180.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="26188" checksum="A575A04D241692EC" modified="2022-01-19" version="1">MASSMETADLSILSVDCSDGDNPYINLYACKPEEVFRLVAKRLDAHWEPIATSLSILNEDIVTIKKEYTELDEQIFQMFVKWKSASGVKTTEEILKVLTTALWNNGRRDLASELETGKWQKPSEPVIQTMSSGKPQGNPSVGEQVLRTLSKKVAGDMETLATWLDVPCERVDKIKEKYRKVNEQTFQMLVWWQRNNPNVNHLALLEIALKKTDRQDLASDLKNGTLMRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2S4</accession>
    <name>A0A8B7Y2S4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087473.1">
        <property type="nucleotide sequence ID" value="XM_022231781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2S4"/>
    <dbReference type="GeneID" id="110977541"/>
    <dbReference type="KEGG" id="aplc:110977541"/>
    <dbReference type="OMA" id="PEYKSKM"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000035">
        <property type="entry name" value="hematopoietic prostaglandin D synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087473.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12551" checksum="3C6E38E1314E585B" modified="2022-01-19" version="1">MVKYVLHYFKAHGRGESIRLAFKLAGVDFEEVNFTFPEWPKLKDKFPTQQTPALEVDGKMLCQSKAILRYLAKEFGFDGKTNLECAFIDQVVDTVEDIWSAANSVFRGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3J0</accession>
    <name>A0A8B7Y3J0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ly-6/neurotoxin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086885.1">
        <property type="nucleotide sequence ID" value="XM_022231193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3J0"/>
    <dbReference type="GeneID" id="110977248"/>
    <dbReference type="KEGG" id="aplc:110977248"/>
    <dbReference type="OMA" id="GCYERET"/>
    <dbReference type="OrthoDB" id="10325660at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034036122" evidence="1">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086885.1"/>
        </source>
    </evidence>
    <sequence length="127" mass="14258" checksum="BE3ED5316FE77D24" modified="2022-01-19" version="1">MAWSLILLALVCTPFAVMGEENMYCFKCAANPECETSVRSDSDNVFLGKCQGVCYDRRITHIAYKETLVYRGCYERETDCVPGCFGNEEHMDCVKCCNKNMCNGAGVVTYSLPIVLLAWLVTRIVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y441</accession>
    <name>A0A8B7Y441_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977810</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087949.1">
        <property type="nucleotide sequence ID" value="XM_022232257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y441"/>
    <dbReference type="GeneID" id="110977810"/>
    <dbReference type="KEGG" id="aplc:110977810"/>
    <dbReference type="OMA" id="KWMTERR"/>
    <dbReference type="OrthoDB" id="6508726at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039499">
        <property type="entry name" value="LURA1/LRA25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037443">
        <property type="entry name" value="LURAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33767">
        <property type="entry name" value="LEUCINE RICH ADAPTOR PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33767:SF3">
        <property type="entry name" value="LEUCINE RICH ADAPTOR PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14854">
        <property type="entry name" value="LURAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022087949.1"/>
        </source>
    </evidence>
    <sequence length="347" mass="39116" checksum="002ECD6C70948EEE" modified="2022-01-19" version="1">MEIDDVDYLDDLLRGMQNKVGATIPLCLLQPILSGSSSDSHMGVNGSSTPTESGERRQMKPTVVDSTENMSSDGGNGHSDNAQIPVSTLQDLSPIKPFSSRFQRLEDKCQKLKNDMSVLRAMDVGVMKQFMTIYDAVEELHWMIESMGDSCESLSSSVYESLEQIHEKWMTERRQWKSTSSRDLSTAWRDDSRVSINHVGRLNSMDSWRQAHSDNRNPRYHGLSLQNINWQSPQKDLNNSFPQITSGRSNFERQRRSSVDHLPITPTATESPQSSPIRPRKRRSSSGALELEVGVVEGDIEEEILEKPAADQRNIHVKKPKFLFHSQSSPSFDPQEQPVDVTDTAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4A6</accession>
    <name>A0A8B7Y4A6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110977845 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110977845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088018.1">
        <property type="nucleotide sequence ID" value="XM_022232326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4A6"/>
    <dbReference type="GeneID" id="110977845"/>
    <dbReference type="KEGG" id="aplc:110977845"/>
    <dbReference type="OMA" id="VMPGHRS"/>
    <dbReference type="OrthoDB" id="10497985at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088018.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35390" checksum="A33788A52DB91668" modified="2022-01-19" version="1">MLGNSQDETDSKHHHDHPCSPLVALRRKLQRVMPGHRSHRSRSLSTDRKTSESNRDSALSTSSEGSELEVHAQMELETMACRQSSGSGHACIQRETVALSTASKCLGDSDKIPEDKTIVHVMSRESQQNDGLLQVTDQVIGTDTSGKPVYKVDFRGCVGCPNTDLVWYMVDPTDCDECKRVYLHTLNPAEPFASAARSGTPLENYSYRLCHFKDGQNSFLAAHKAGKARSNQKFDVDWSGLIDVCYHPTKGGMVTLQENSNSHRAMDGLFFGASRDGEVHLFGKSTCQGYCINPFTLFYVYDDVSGEQSEELKRTNGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y879</accession>
    <name>A0A8B7Y879_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PHD finger-like domain-containing protein 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089433.1">
        <property type="nucleotide sequence ID" value="XM_022233741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y879"/>
    <dbReference type="SMR" id="A0A8B7Y879"/>
    <dbReference type="GeneID" id="110978619"/>
    <dbReference type="KEGG" id="aplc:110978619"/>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089433.1"/>
        </source>
    </evidence>
    <sequence length="110" mass="12405" checksum="90F7469DE7292BF7" modified="2022-01-19" version="1">MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA79</accession>
    <name>A0A8B7YA79_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Trypsin alpha-3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110979019</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090153.1">
        <property type="nucleotide sequence ID" value="XM_022234461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YA79"/>
    <dbReference type="GeneID" id="110979019"/>
    <dbReference type="KEGG" id="aplc:110979019"/>
    <dbReference type="OMA" id="VFANSHQ"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000120">
        <property type="entry name" value="Putative serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034681113" evidence="9">
        <location>
            <begin position="20"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="10">
        <location>
            <begin position="22"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022090153.1"/>
        </source>
    </evidence>
    <sequence length="260" mass="27261" checksum="0ABD7BB44C0F4B7A" modified="2022-01-19" version="1">MKFFVPLACLLAVLAPVLGEQIVGGYESKANSRPYQVALYDSSSGNFQFCGGTLVNSRWVVTAAHCVKGSSVYVGLGYHDKYSHSGSGQQFIRGTWRRHPSYNSGNLDNDIALIKLDSSANTGSSKISTISISSSKPSSGTSLLVSGWGTTSSGGSSSRKLREVVVKAKSTSDCKKAYGSSSITSNMYCAAASGKDSCQGDSGGPIVSNYGSNYHSSGTRLRGVVSWGYGCADSRYPGVYTNIANYCSWLSSTSGGAVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAD8</accession>
    <name>A0A8B7YAD8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110979047</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090214.1">
        <property type="nucleotide sequence ID" value="XM_022234522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAD8"/>
    <dbReference type="GeneID" id="110979047"/>
    <dbReference type="KEGG" id="aplc:110979047"/>
    <dbReference type="OMA" id="HNYDNVN"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090214.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="39743" checksum="4549D409C07EF900" modified="2022-01-19" version="1">MVISPREPINGENATLKCTAGDFDPDLHSWVWQKGVNESYFDVTASDRILFSPVERAFLTFYSQTLTIVGLKESDEATYLCIVVESSTGTFINNGAGALFVNYPSEFPVCSPEGPAEVMVGDSLYCRTVSDERSPDARTSDYVSSLKSDWILISLNDTETGSQLEKKVTSIDDELTFFCFSISEKTNKTLSCKIGPLTVTFEASSITSPLLIAGIVISVLVTVFSFCVILLCFRYSPQCLCQIRMFFSRSDTPFPQSDSNNLSELQTGNHLYETSITGPPADGFHGGSGNNVLAAENRSLNTSEVDQNLTSVSECGMSHEGAFFKLNKKDNSNSMTKSANTDSYMELNPSKLNTDMYTELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAM8</accession>
    <name>A0A8B7YAM8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">F-box only protein 43-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110978245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088756.1">
        <property type="nucleotide sequence ID" value="XM_022233064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAM8"/>
    <dbReference type="GeneID" id="110978245"/>
    <dbReference type="KEGG" id="aplc:110978245"/>
    <dbReference type="OMA" id="REWRQIC"/>
    <dbReference type="OrthoDB" id="9984940at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20348">
        <property type="entry name" value="BRcat_RBR_EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22086">
        <property type="entry name" value="F-box_EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047147">
        <property type="entry name" value="FBX5_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493">
        <property type="entry name" value="F-BOX ONLY PROTEIN 5 AND 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15493:SF9">
        <property type="entry name" value="GH14043P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="IBR" evidence="7">
        <location>
            <begin position="234"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022088756.1"/>
        </source>
    </evidence>
    <sequence length="319" mass="35658" checksum="556B2B1F2AC185D7" modified="2022-01-19" version="1">MAEPEDHNKEEKISSALPLISSNSAHHLDFPRETPICRRSPKKVRASSDMSEEISYATPVVEFTRIVPRDEVYGTPAVSSNSLSKFYKEAMADEDSGYGSPGMLVEHAGRPCKMGLEKLDIITELKHHEPALLNKITRELSDGDIVRFSCVCQEWRNIVKFSPMAALRKKCFLLETPKPTKDVKENYPKQPFLRDTVSAATPLGEVQRLGEPQASSTPAPRLSNHDKFRQASESLLADESLTKCAKDACQSPAKLLMNGQRAQCMRCGYDFCTNCRCEFHVSSVCPAFREKNSAKKKNSIGSGKSKRSLRRLARLESYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAP7</accession>
    <name>A0A8B7YAP7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C17orf105 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP97 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089627.1">
        <property type="nucleotide sequence ID" value="XM_022233935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAP7"/>
    <dbReference type="GeneID" id="110978718"/>
    <dbReference type="KEGG" id="aplc:110978718"/>
    <dbReference type="OMA" id="MHKSYQP"/>
    <dbReference type="OrthoDB" id="2163395at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038792">
        <property type="entry name" value="CFAP97D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029488">
        <property type="entry name" value="Hmw/CFAP97"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33768">
        <property type="entry name" value="MIP11318P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33768:SF3">
        <property type="entry name" value="MIP11318P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13879">
        <property type="entry name" value="Hmw_CFAP97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089627.1"/>
        </source>
    </evidence>
    <sequence length="142" mass="17409" checksum="4AE95EF387DC4CD1" modified="2022-01-19" version="1">MHRAYQPITPANNKLLKKRWDDRRFDRHRQKVRNAKAVIDNKPPQTYMHLHLKLKKLQVEEERLATIERDNRILLEKMCSIMRTRGRVDCENEYEQKSLNRTKRQREILRVTHENQAILRRILSKEANYSHQKWEHEWAVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YB57</accession>
    <name>A0A8B7YB57_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipid droplet-associated hydrolase</fullName>
            <ecNumber evidence="9">3.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lipid droplet-associated serine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110978329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36403"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17002"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:36404"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily. LDAH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.13" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022088941.1">
        <property type="nucleotide sequence ID" value="XM_022233249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978329"/>
    <dbReference type="KEGG" id="aplc:110978329"/>
    <dbReference type="CTD" id="60526"/>
    <dbReference type="OMA" id="WVPVSYY"/>
    <dbReference type="OrthoDB" id="448051at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000068">
        <property type="entry name" value="Lipid droplet associated hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019363">
        <property type="entry name" value="LDAH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13390:SF0">
        <property type="entry name" value="LIPID DROPLET-ASSOCIATED HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10230">
        <property type="entry name" value="LIDHydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022088941.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="36505" checksum="F9DEB1E1D0DD344D" modified="2022-01-19" version="1">MNPVAMATKYKDEIFCAAEYISVRGIQTRIMKVQKRDSDDDRSDVDVLDVLFLVIPGNPGVVDFYEVFMQTLYKASAYRASVWGVSHAGHTLLPKEHNTDTYSLDDQIDHKAAFIQDFVPKDKRIVLIGHSIGCHIILQVMKRHPTLPILKALLLFPTIERMWSSPNGTVLAPFLCYARWLGVLVVFLGSYLSDWVKWRMINWFLKDKKVPTCAFHAALNLFNPGCANNALTMAAHEMREVVEPDLDAIAQHLPKLVFYYGATDGWCPVDYYDDMRALFPEGDIRLCKRGXSHAFCLESSELMADMVWNWLWNVIVPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YC92</accession>
    <name>A0A8B7YC92_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110979033</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090187.1">
        <property type="nucleotide sequence ID" value="XM_022234495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YC92"/>
    <dbReference type="GeneID" id="110979033"/>
    <dbReference type="KEGG" id="aplc:110979033"/>
    <dbReference type="OMA" id="WPNGREN"/>
    <dbReference type="OrthoDB" id="10018421at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF11">
        <property type="entry name" value="GIY-YIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090187.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="28234" checksum="364CBB4CF29EA185" modified="2022-01-19" version="1">MVSFDVVSLFTCVPTSDTSTIASDRLQADTSLKDRTDLTPNQLQDLLTTCVDSASFQWRDKFYEQTAATSMGSPISPILAGIFMEECEQTAIATADHRPKIWLRYVDDTFVIWEHRQDNLQLFMDHLIVLHSSIQFTMEQERNGSISFLDVEVSRRKDGSLARRVYLKPTHTDRYLNSASFHHPKIKSSVNRALIRRAYNICDQEHLHKELHHISTALQRHGYQPKQIKTQDQVPLPAVGSPIPKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCD7</accession>
    <name>A0A8B7YCD7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110979435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090908.1">
        <property type="nucleotide sequence ID" value="XM_022235216.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022090909.1">
        <property type="nucleotide sequence ID" value="XM_022235217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCD7"/>
    <dbReference type="GeneID" id="110979435"/>
    <dbReference type="KEGG" id="aplc:110979435"/>
    <dbReference type="OrthoDB" id="10066259at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000013">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF5">
        <property type="entry name" value="POU DOMAIN MOTIF 3, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="POU-specific" evidence="10">
        <location>
            <begin position="469"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="563"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="565"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="631"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022090908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022090909.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="67161" checksum="CD47EAB0A8E2545E" modified="2022-01-19" version="1">MIMDGESANQHIVGNGKLDPAVTISGALPSVSVANVITGTQDPMVSGQMTLKTTSNAKPQSASDQLLLAMQSATGGQAIRSGMVISPTKQAFQSGLKGLGTTIPASLGNSTSTQQLLLSPPIQTLQSPQQVLTNQLSAAQQIFTIPSNNATGQQQVLTLPITNAAGQQQILTIPVSLAQTSGGIQFLIPTSGGQLLAANIGGVVPTMANASTGAASQTNVTSALAGLTQTTSVTSLSKQYTSSSSTSAAAAAQPATTTAATTPLPSMSVLASQTGLGQLPLPQMLMNATGLNSSARALAAAGLATMVSAPPLTQVGQLGATNQQTTATPVLTTTQRAAVPAAAASTTAATTDPAAAGLTSQQIAAHGLASTGQLLASHGLPKQLITTQSPVIVGAGQATGAQAAGVQQLIGGQVVTQAVVGSTLVTTQANNQVTAAQVKAPSSPTNNTATVTGSSSGKAVSSLGNTTEVDGINLEEIKEFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICRFEKLDITPKSAQKIKPVLERWMQEAEERHKNGLSQLSDYIGSSEPTKKRKRRTSFTPQALEYLTLQFEKNTHPSGAEMTAMANEINYEREVIRVWFCNKRQALKNTIKKLKAVNDAGSPQETDPSETVVIKTEETYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGH1</accession>
    <name>A0A8B7YGH1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110980206</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110980206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092338.1">
        <property type="nucleotide sequence ID" value="XM_022236646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGH1"/>
    <dbReference type="GeneID" id="110980206"/>
    <dbReference type="KEGG" id="aplc:110980206"/>
    <dbReference type="OMA" id="TAPHREN"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="entry name" value="Formiminotransferase, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="entry name" value="Formiminotransferase, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051623">
        <property type="entry name" value="FTCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234:SF1">
        <property type="entry name" value="FORMIMINOTRANSFERASE N-TERMINAL SUBDOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234">
        <property type="entry name" value="FORMIMINOTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="Formiminotransferase domain of formiminotransferase-cyclodeaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formiminotransferase N-terminal subdomain" evidence="2">
        <location>
            <begin position="3"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022092338.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="38393" checksum="9664CC28E4215E03" modified="2022-01-19" version="1">MKRLGICLLNISEGRNPKVVEAVARAAVSTAQEVTVSDAEIGLQCKSTVLNVFSDYDYNRSVLTIAAPLKYLQDSIYNACREAYGQIDLGKQRGVHPRLGAVDLLPIYPLSRDVRVEECGVIAKEIASTLAVDIPGTSFFLFGTSDVPHNRDLVARRKEVGWFLGRHHTDYGSLQYDLGSRPSAKYGLTGAGGSLYVTNYNVSLATSDVSIGHEIAQRIRSTTPGGLPGVRVMAFAHEGNVEIACNVENIPMDAAEDTPCSEPTESQTSTTKTHQTDCSALPSDAPQDTYRQIRYTSPAEIEARVKDLASEHDVGLVGTSIIGFTPHEAEELAIHALQTGQTELWRTRVPGTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGZ2</accession>
    <name>A0A8B7YGZ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein LOC110979854 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091665.1">
        <property type="nucleotide sequence ID" value="XM_022235973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGZ2"/>
    <dbReference type="GeneID" id="110979854"/>
    <dbReference type="KEGG" id="aplc:110979854"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034990804" evidence="6">
        <location>
            <begin position="18"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="8">
        <location>
            <begin position="37"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="140"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022091665.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="41110" checksum="D364EDDCFBBFD863" modified="2022-01-19" version="1">MTTRSSLYLVMLTLVLSTPVCSLAPIYGNEDPLLPNRYLVHLKEHSNVHHTIAAMEHLSKRSQLLSRVHGIFEHVIKAFVAEMDHDSLQSILSNPEVEFVERDQTVHILRQEGDIPWGLDRIDQRDLPLDGKYEVEVGSGAGAHVYVFDTGILASHEEFEGRADVVFDYFGEDGVDCQGHGTHTAGIVGGKTYGVAKEVALHAVRILKCDGMGSVSGVIAGLDWVKSNGIRPAIASMSLGGNFSLSLSEAIWKTVSSGIVVTVAAGNEHTDACTVSPANSVKAITVSATNIHDREASFANVGPCVDLFAPGIDIRSAWISSTTASRVASGTSMACPFVAGAAAILLGNDPDMTPDDVRMRILSKSSRKVQTANATSPHKLLYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH12</accession>
    <name>A0A8B7YH12_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">medium-chain acyl-CoA ligase</fullName>
            <ecNumber evidence="10">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110980284</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48341"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022092529.1">
        <property type="nucleotide sequence ID" value="XM_022236837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH12"/>
    <dbReference type="GeneID" id="110980284"/>
    <dbReference type="KEGG" id="aplc:110980284"/>
    <dbReference type="OMA" id="HAWSNLF"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A synthetase ACSM2A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A synthetase ACSM5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051087">
        <property type="entry name" value="Mitochondrial_ACSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605:SF10">
        <property type="entry name" value="ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="12">
        <location>
            <begin position="107"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="13">
        <location>
            <begin position="526"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022092529.1"/>
        </source>
    </evidence>
    <sequence length="619" mass="69455" checksum="2D5F0A5459B40801" modified="2022-01-19" version="1">MATVLKPYQLLSIGQFHRGIQLLRSNSRRLGASYSILRSYTPCSTRRTHPSQAVHYQPIRSFLSALSATGFNDYELGRRQFKLDVPEYFNFASDVLDEWAAKEQTGTRSSKTPALWWVDDHGNEIKWSFLDLKNKSMKVANILTNDCGLAKDESVMVILPRIPEWWLLNIACLRTGTILIPGTTQLTARDIKYRLLASGTSCIVTDDHTAPLVDEYISECPGVKSRLLVSNSGQSRPGWLEYNDLFEKADGQHQCVKTGSNETMTMFFTSGTTGKAKLAVHTHASYGLGHIITGKYWLDLIPTDVHWNISDTGWAKSAYSNFYAPWVQGACVFISYTAKFDAAHTLELLHKYPVSTLCAPPTAYRMMVLEDLTKFNLKSLRHIVSAGEPLNPEVMDAWKAGTGSMIHEGYGQTETVLLMGMFKCLEPRPGSMGKPAPGFDICIVDEDGNELPCGEEGDVGVRVKPHRPVGLFTHYVDDPERTARAFRGDFYLTGDRALVDEEGYFWFVGRSDDIITSAGYRIGPFEVESALIEHPAVAESAVVSSPDSVRGEVVKAFIVLTEEYKSKDKEQLMKELQEHVKNITAAYKYPRKIEFMESLPKTVSGKIRRVVLRSQEWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YHQ1</accession>
    <name>A0A8B7YHQ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein bicaudal C homolog 1-A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110980420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BicC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092774.1">
        <property type="nucleotide sequence ID" value="XM_022237082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YHQ1"/>
    <dbReference type="GeneID" id="110980420"/>
    <dbReference type="KEGG" id="aplc:110980420"/>
    <dbReference type="CTD" id="80114"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22420">
        <property type="entry name" value="KH-I_BICC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22421">
        <property type="entry name" value="KH-I_BICC1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22422">
        <property type="entry name" value="KH-I_BICC1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.270:FF:000002">
        <property type="entry name" value="BicC family RNA binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054727">
        <property type="entry name" value="BICC1_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047549">
        <property type="entry name" value="BICC1_KH-I_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047554">
        <property type="entry name" value="BICC1_KH-I_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047553">
        <property type="entry name" value="BICC1_KH-I_rpt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF69">
        <property type="entry name" value="PROTEIN BICAUDAL C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22985">
        <property type="entry name" value="KH_BICC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24234">
        <property type="entry name" value="KH_BICC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="1143"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="818"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="922"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="999"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1057"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1212"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="755"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="834"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="941"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1066"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1212"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1226"/>
            <end position="1246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022092774.1"/>
        </source>
    </evidence>
    <sequence length="1246" mass="134473" checksum="03B1479299D5FAC2" modified="2022-01-19" version="1">MADLMDTVSDLRDLGVAVSSNNNNSGFSSDNSSDLSQPMGALEDEEGEEDSPGQVSVCDPEHMEERFRVDRKKLEEMLQAAQDGKAETGEEFFQRIMQETDTRITWPSKLKIGAKSKKDPHIKVTGKIENVVTAKDKIMAVLDTKSNRVTLKMDVSYTEHSHVIGKGGNIIKKVMQDTGCHIHFPDSNRGSQQEKSNQVSIAGQIGGVEQARAKVRELLPLVLVFELPITNNPTPDINSPTIQQIVQLYNIGVNMKQRARGYSTTVTVRGSSSNAVGVKEGTMRLMEHLIGNIGVTLPVSTQIEIAPQHHQFMSGRGGLNVKQIMQGTGATIHFPDPNNAQRKSTVFISGPVDSVIIARHLLMGCLPLVLMFDVKEEVDIDASKLAQLMEQLDVFISIKPKPRQPSKSVIVKSIERNAPSMYRARQILLGQECESCAANCSNATRGLNGTSLPLSGLLNSNLVSINTSNLLSVNGLSRVSPLQSPRSSVSGPNGLTWPAVSQQSTGLSHSFPAGVTPVLISQQTIKPLLVQPGQNALQNQKVLQSQSAPQSQSACQGQNTFQSQGTLQGQTALQGQSACQGQSTLQSQGTLQSFPNQVQNPTHIPSLNPVPNPTPVPITNPALNPNVSPPVHLGANPLFTPTTAPTSPPPLANPPSAPIQLAPNMAASLQVVTRPAAEPTQAYILSSAALPVTNTVVNTEPHKVAIPSAVRANPQAEAPKTIQQNTMAQQLTYIPQHRVSQPEPHRVIYPTPHQTEAQRVTHSSPQRVHPTSPPPGLTKADPDLLSTELQRLHMAAKAAQLISSCGGEELTEHIAQASQIDRQLSSPTKDRVMSSSHSNTSSGTSPNQSPCNSPIDLISMPTTPPISSSNNNNPKLVDLGYLQNNISPNNSNGNLSGVLMGSGGRGSLTLLQDGTLGLTGSGLAYHTNGRRSSESGGDSDSSDKRAPGCERRDRDRERGEWERGREKERQEEVDRLALQSTSASYGSIDYDQKKLKANKAMKKKPIGTEVRRPTDQWSGLGFSKSMPESAIREQRKPNGFSLFHTEKLPTTYENTLKEETENGTTDSSWPPDQPSPSIDLMTCQQPEQPQPTSAAPGEYPANRKKKVTYTNLSCSNYIEGSSLPGQTKGLWSSSEGSNSLTQSKKPDLADLFINLGLGKYADVFQQQEIDLSTFLTLTDNDLKELGITTFGARRKMRLAISNMNKGKTKPSLFSANNSSSLLHEGSNGSNGLIQSSHGHESPTSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YI73</accession>
    <name>A0A8B7YI73_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979636</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 6"/>
    <dbReference type="RefSeq" id="XP_022091326.1">
        <property type="nucleotide sequence ID" value="XM_022235634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YI73"/>
    <dbReference type="GeneID" id="110979636"/>
    <dbReference type="KEGG" id="aplc:110979636"/>
    <dbReference type="OMA" id="IEPDWAY"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21063">
        <property type="entry name" value="BTHB_FKBP25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043368">
        <property type="entry name" value="FKBP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041200">
        <property type="entry name" value="FKBP3_BTHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46493">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46493:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18410">
        <property type="entry name" value="BTHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="146"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091326.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="26991" checksum="38CAF20AFF3AF5AB" modified="2022-01-19" version="1">MHTRGSVPLNQIFSVFPASMAAENEVTRPWTDEEIVSDDIGKKAIATFLQEHASKRFLRDHKMLGALKHVVKTCNKDQFVKAYKDLFEKKAFKGPGDDEEELEEVTKKTAEVHVKPKPKEEKVAEVPHFTKKIVKQGDKSTFPKKGDYASVWYTGKLTDGTVFDTNITTGKKKKAATPLKFKVGTGQVIRGWDEGVLTMSLNEKAELTIQPDWAYGKKGKPESKIPPNATLIFEVELIGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIS3</accession>
    <name>A0A8B7YIS3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylhydrolase ARH1</fullName>
            <ecNumber evidence="4">3.2.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ADP-ribose-L-arginine cleaving enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">[Protein ADP-ribosylarginine] hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110980273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically acts as an arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosylglycohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.19" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022092507.1">
        <property type="nucleotide sequence ID" value="XM_022236815.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980273"/>
    <dbReference type="KEGG" id="aplc:110980273"/>
    <dbReference type="CTD" id="141"/>
    <dbReference type="OMA" id="HEVAFCY"/>
    <dbReference type="OrthoDB" id="10250509at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003875">
        <property type="term" value="F:ADP-ribosylarginine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051725">
        <property type="term" value="P:protein de-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4080.10:FF:000002">
        <property type="entry name" value="ADP-ribosylarginine hydrolase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012108">
        <property type="entry name" value="ADP-ribosylarg_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF26">
        <property type="entry name" value="ADP-RIBOSYLHYDROLASE ARH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016939">
        <property type="entry name" value="ADP_ribslarg_hdr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605502-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022092507.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="38549" checksum="D4E1945F7CE9481C" modified="2022-01-19" version="1">MLASRYKAAMVLSGVGDAMGYRSGKWEFSFVGEDIHKDLKKFGGLPQLKISLPGWPVSDDTVLHIATAQALATNKPVGEELFLELAARYIEGSKDMSGRAPGGTTLNAIHLLKPHQAGGYVIPFNNRAGGCGAAMRSMCIGLRYPRPEQLSDLVAVAVESGRMTHNHPTGYLGSLAGALFTSXAVQGKLVREWGAGLMATLPKAREYVESVGRDVPENKEKWNYFEAQWKSFLKLRGLTDGNSDPKFPEQYGVKERDEFYKSVSYAGWGGASGHDAPMIAYDALLGAGDSWKEMCLRGVLHGGDNDSTGAIACCWWGVLYGMEGVPXXXFQDLEYRSRLEELAQKLYDLSHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIU5</accession>
    <name>A0A8B7YIU5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110979781</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091526.1">
        <property type="nucleotide sequence ID" value="XM_022235834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIU5"/>
    <dbReference type="GeneID" id="110979781"/>
    <dbReference type="KEGG" id="aplc:110979781"/>
    <dbReference type="OMA" id="KVRNCLP"/>
    <dbReference type="OrthoDB" id="6515930at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000123">
        <property type="entry name" value="Crumbs homolog 1 (Drosophila)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000004">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000327">
        <property type="entry name" value="neurogenic locus notch homolog protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000018">
        <property type="entry name" value="Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0768">Sushi</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="193"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="16">
        <location>
            <begin position="243"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="15">
        <location>
            <begin position="305"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="15">
        <location>
            <begin position="392"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="876"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="914"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="952"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="990"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1028"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="1066"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="978"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1054"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1092"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022091526.1"/>
        </source>
    </evidence>
    <sequence length="1165" mass="127375" checksum="E7F1621D4CAC35BE" modified="2022-01-19" version="1">MYDTSVNQTLCDNICHKPFNDTDYGCCDFSAKCTCSLVGGRHDCVCGPGTYGRSGFLYECKLCPRGSYKSTYEPTDGCTPCPPDSTTTYPGSQTVAACECKEGYEGNPQSGEPCRIVSCPPLTSLRNGRILPAPCDNKYQSVCSFECDVGYELQDPASAKRRCQADGHWTETVAQCRKVQCPALIPPPNGLIVQCRNQEAGKRNVYDTTCSFRCNDGFNPVGNRERTCTASGEWSGNFSCTPITCPAFPPLRHGSTQPSKCSTRRPVNFICLFKCKDGFKLRGPSFKTCEAGGSWSRAGEEVACVDDTPPEIITCPRSVVKDADPGLSSAEVSWDMPTFQDNLDRTDALTVMVTPDGLKSPHRFEIGSVVITYNVTDRAGLSSLCLLKVVIRDTEPPTVDSCPGPIIDITSKKKTKSVSWDEPEFADNSKQELNIEKTHEQGADFTWGSHIVTYTARDGAGLSIECQFTIRLGPTRCPNYPDPRNGARACDAWLFGQFCRIFCNAAFDFSEKPANYYICSHGKWRTVPPRMAIPWPDCSERAAADGYRRGMESQYYAGDCSDEKAQRAIKEAFVEDFKKSVMGQNGGCVADNACTVEYVTVYCGEIDEDRRRRRRRQTAGDETDFGSIVTLDFTVSTRIRSVAENKTLLRAQQRNAEQTLDEISWDYERLAQAGQLRLLVENETLPVVEGSVTINESVPLCRRGSVVLNETDCLSCTVGSYFDSKTETCKVCAEGTYQDEEGQDECKPCPWGTWTDGPQAKDVNQCRPECKPGTFSPTGLATCRPCSRGFFQPSFKQTACLPCREGTTTSATGSRSSRKCQAVCGPGTFSATGLHPCQPCPLGSYQPAEQQTQCIPCAGSGTTAFNGSTSGEECIEIDACESSPCQNGAVCNNDRGTFNCLCMTGFTGTTCEIDIDECWSQPCLFNGTCVDNVGGFDCHCMPGYEGTLCQTEINECLSDPCQNEARCQDQVNGFECNCVDGFWGPLCENRPDPCAGQACLNGGFCIETPGSFQCLCQSGFKGLRCQTDVNECDLQPCQNGGSCENTPGSYQCACQPGFEGTHCEVNIDECQDHACANGSSCRDVIAGYQCLCPPGVTGQLCETEMSQEFLLDFTNSRTSEFSLLRTKISPDFVDLILRLDTRHHRMHRGSVTRVHENSVGCARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJ41</accession>
    <name>A0A8B7YJ41_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exonuclease V-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093269.1">
        <property type="nucleotide sequence ID" value="XM_022237577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJ41"/>
    <dbReference type="GeneID" id="110980682"/>
    <dbReference type="KEGG" id="aplc:110980682"/>
    <dbReference type="CTD" id="64789"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093269.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="51149" checksum="5A1BCC0544DA81FB" modified="2022-01-19" version="1">MMDANDMNEAIHFGSQDDALFHQALDALEMMDEAGPMNVKDASDSQESISESQNRALHHAYEANEQSATRMSNVKFSDHNIGSENLTCGPSCNACSAGTGSTSASCTTKTEDSESSLNAFSGVETDRKQKLRLGNTYLTVSNLVAQLWCEQQMVYNFWKPDLELIVESTSTMPAEHKAAVKAVVAAASSGSRVHEKRDHEVNKYIPVKVKTREDNYGIRLVNIMVSLRGLLLRGEPCAREIPIFGLPLGHGFVVVGTIDELRFDSQGRFELVEFKTRGDISRPIRRQQMQAYKMQMMMYKKMLEDLGRGHVDGQAVLHGLKMDPHQILNDELLKYVRQLGDASRTSVTLGELMSEVMQQFEFLPYVDVLTLEFSSRDDSATITTETVDFDADWLQQRLDHCHAFWAEERDAEGVDIEDTWKCGICAFYDRCEWRQRMNEICAQKNIARRLQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJ43</accession>
    <name>A0A8B7YJ43_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretory phospholipase A2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092637.1">
        <property type="nucleotide sequence ID" value="XM_022236945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJ43"/>
    <dbReference type="GeneID" id="110980344"/>
    <dbReference type="KEGG" id="aplc:110980344"/>
    <dbReference type="OMA" id="CMTANAN"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="1">
        <location>
            <begin position="75"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092637.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="24333" checksum="1016D040EF30A14E" modified="2022-01-19" version="1">MIQNVVASGFQLDRGEWIGCQDDNVISDLWCSAGSQKMDFAPTGSDQNIQIGTERKLAEAGFSTATSCPPGWKKWNRSCFAVNIERMSWMEASDFCESKGSRLAVPNSQAENDFIWQTAVEQFQAESTRRNGVWIGCKKESANSSFMCSGGREKIGFTNWEADSPGHEFPQCVVYFKRGNGKWTSNDCDPKGGKFAACEMSTPPGMHCLTANASGRFVSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJU5</accession>
    <name>A0A8B7YJU5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Trichohyalin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC110979944</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091836.1">
        <property type="nucleotide sequence ID" value="XM_022236144.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091837.1">
        <property type="nucleotide sequence ID" value="XM_022236145.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091839.1">
        <property type="nucleotide sequence ID" value="XM_022236147.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979944"/>
    <dbReference type="KEGG" id="aplc:110979944"/>
    <dbReference type="OMA" id="ISIIICH"/>
    <dbReference type="OrthoDB" id="8852462at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098797">
        <property type="term" value="C:plasma membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022076">
        <property type="entry name" value="Limbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026501">
        <property type="entry name" value="Limbin/EVC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16795:SF14">
        <property type="entry name" value="LIMBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16795">
        <property type="entry name" value="LIMBIN/ELLIS-VAN CREVELD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12297">
        <property type="entry name" value="EVC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665583" evidence="13">
        <location>
            <begin position="25"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1414"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="901"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1006"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1251"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1125"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1149"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1414"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1430"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1463"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1477"/>
            <end position="1495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022091836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022091837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022091839.1"/>
        </source>
    </evidence>
    <sequence length="1581" mass="180476" checksum="1BDD2B3134E8A310" modified="2022-01-19" version="1">MALQDFIFISIIICHLVCLQGCHSQLVDVALQVNTPTSNPMVGSFPSLYLTDHLTISVGLQFGSAGDHVRLSVEIPDEFAQVAAENLTITYASNLQDAQEIIQTSRTQLNVSFGEVEVINATLGNTSLENVIDLRRTLYVQNSQNIGYLLNVTLSVDYGPSYEETFTASRILSYAGPEVNTNKLAIAQDQPFIFDREMEASASFQIPPGSWNMSEIQVISDFVSEDISFINLDVLSCLATSDSPNITFSNPASQNVTSFTNASSPVAFVTIQNATSNARRRRVATAGNQASATLIWNLFDIVNTGDSVETVNFTIRLIIGQTAQTVKGVMITYTFTMNLNQEDIPLGNSVLVVSEPDLILDKTLTVLDEAVTEDLDYSLNYLRFTTTLSHSPQSGTPAYGVVFKDQVQGFILEYFTDLEPAYGTDGFTVSSQELVYQVDKLMVGDTLTFSYKAYFSDDTVTNDIGTSLTHVAMATWHSMPTQEITAEHPGRSYSPTVQPETCITPVETQEESIIYDHGLAAVLFFVALIIGCIIVALICLICIKCCRKGPYATVQPIGKNAGGSKGQGLVMNAKGGARSGLSNLKEFCLIAIDDSIVMVLALKDKARKLLEFENLDIWWTITIDIQLEQQRIDAMVESSINLVSKWATEGTVPKKICDKSNRKFQRKVKDLSKTLDDEYKEECRELIKELSARNKLKLAELQRKHKAEYNDTLTQTKGMTEEERREILLLLRQQHDAEKNEVMQLLKLHQDERQEKARKEIAIRKRLGVKSLQEGYLDEVILQSKLDEDAAARLLREHRSNMQDLETAMDDELSRQRMLLEEKLAKRRALAQSNDSLGDHHKQMLNTMVTQTLGVIDELEKDDKLTEAEAERYTQRLRQEFMAAKAGYDKEKSKQEEALHKRLSELKKRKLEERAREHKQQLDQFEKEQRAKLENNNLDPSQYMDAKTDLLASQRSEMHELELSLDDDAAKQLDDLHKKLAGETKEKLTRSKEGFFKDLMSHGMTERMKNEILEQHQRDMERLAEEHEEQRLKQERLLKKRLARHRQEWINRKQEEKQEQQMIRDHEEKVVGRILASQLAISEEDRQRILDEHEKQQVALDSSLALQKLKQRRLLEERVTQRRARQMEKLQRKHTQEAQRMARKQQLADSDEDGEETQQELIKKQAEEKIALLSGNDAEDIEDELEAVRVEMMQAKVVALKEQEEHLGTLVAKLQLERSREIATIEEQQKALWQLKMNMLDNMTEEGIIRNADCKKVIETHQKEAKNLENKLKAQREKQEKDFKRRLRDKLADREQIFLSKQEEELQRLSENEKNKTSARLKRVALKHKHLMEMEEFRRNLEIEVNQALEDLRRNFEVERLRQLQEQELQFISGIVKHGKFSLAELRNILYLLFPGKTEKDLEPLLRKMYNKEEGEELGEEKEEADDVANNGNQRRSSVKQMKMGKPSKAGTSLEEKIKLSILGNTNDSAVSTPSRERRRPNKLLKKLKKNKQNKKLAPITSGAGHDDQDRPSKPAFQGNALPQIGMPRPEPLGGTATPIDDADIDRRARMDTDSEEEERQPLKKKGGGRGVNTGQSEYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKB8</accession>
    <name>A0A8B7YKB8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110980930</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110980930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093704.1">
        <property type="nucleotide sequence ID" value="XM_022238012.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093713.1">
        <property type="nucleotide sequence ID" value="XM_022238021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKB8"/>
    <dbReference type="GeneID" id="110980930"/>
    <dbReference type="KEGG" id="aplc:110980930"/>
    <dbReference type="OMA" id="RVSHLHH"/>
    <dbReference type="OrthoDB" id="10590887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022093704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022093713.1"/>
        </source>
    </evidence>
    <sequence length="680" mass="75930" checksum="47F1DBF3D609EF2E" modified="2022-01-19" version="1">MAAEMKKHTDNSNGSKEKIPLNQTVLSSVSAVVEESFQEASAAARFQNYVGTAFFNDTIRPCQREQILVAVREVIGNLFWQACVAARAQMRVEDQSFVKGVKWRNDIEEDTVAKSSHASQSYGHAVGNSTASEQGCWSSSLFQLNSVSRLSCEESLQTEETSVAMETFKPLSTEITDPNEMARDDLKQLRFLRTVSEKPIFQDSRESKNGQCITKRVDDREVSQDSKSKTVSNSLMGQKDALDCFKGQEMSAPWSAVSFVVSSVATPKDDISPDLAQSRQDEPLCKILKLDEKSCRNCSIISLKSDTDREWDQPTLKSSENFNSCYDRKSDKALRSTPLTLAAREETPVPDECFEDTSSKGIQALSSVIDISQKNVTCRDEKTGEHIPNDISIKEETSEVDYEMPATRMALQDVGQKLQLTRENEEDMHTGQPDPSAELDKKIDFSLVYETVPPEPTRPIDDDYKHLAAEKKQASDADWIKLEGPSEQITEEVLPENGPKRGNVKPTNDQMVPSLLEEDGDKTPEDRAHELYADDDEEVSIEVKHREADVTGTSLSPTPSSTLNEVNEEQLNEEVSGGTKDRSNAVPIGNQLVPQTSTGIFQWRHGISYENQQPASSRSPLGSLDQQTVPDLEWRPSPLPACNRKRRLGLSRRQRVSHLHHINHLPCQNTRPSPNTGHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YN20</accession>
    <name>A0A8B7YN20_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12 15">Uricase</fullName>
            <ecNumber evidence="5 12 15">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110981412</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12 15">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12 15">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12 15">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5 12 15"/>
    <dbReference type="RefSeq" id="XP_022094663.1">
        <property type="nucleotide sequence ID" value="XM_022238971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YN20"/>
    <dbReference type="GeneID" id="110981412"/>
    <dbReference type="KEGG" id="aplc:110981412"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7 12 15" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="13">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022094663.1"/>
        </source>
    </evidence>
    <sequence length="301" mass="34100" checksum="08B4FCE249F9413F" modified="2022-01-19" version="1">MSRTGSGPKMDLVSDGTYYGKHRVRILQHFRHGNTHNIKEVAVNTHLSLARQRDYLHGDNSDVIATDSQKNTVYALAKTKGIRTPEQFAMDLSRHFLTTYEQVVRTEISVEEAPWHRMDHSGKEHVHAFIHRQEAKRFCIVQQEKNGLPKVSSGLSDMKVLKTTKSGFVGFVRDRFTSLPETTDRILCTSVRGKWSYSSVAGIDFDKTWEICKNTILDIFAGPPETGMYSPSVQQTLYQAAQQIMAKVPQVDKVELEMPNIHYLFADLKKIGMENSGDILVPTDEPRGYIRAAVCRTTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YP83</accession>
    <name>A0A8B7YP83_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Collagen alpha-5(IV) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110981655</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095084.1">
        <property type="nucleotide sequence ID" value="XM_022239392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981655"/>
    <dbReference type="KEGG" id="aplc:110981655"/>
    <dbReference type="OMA" id="DIGGRCN"/>
    <dbReference type="OrthoDB" id="10071882at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.240.10:FF:000001">
        <property type="entry name" value="Collagen IV alpha 1 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.240.10">
        <property type="entry name" value="Collagen IV, non-collagenous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001442">
        <property type="entry name" value="Collagen_IV_NC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036954">
        <property type="entry name" value="Collagen_IV_NC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01413">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SMART" id="SM00111">
        <property type="entry name" value="C4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51403">
        <property type="entry name" value="NC1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="6" id="KW-0176">Collagen</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034280356" evidence="9">
        <location>
            <begin position="29"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen IV NC1" evidence="10">
        <location>
            <begin position="1535"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="940"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1125"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1152"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1241"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1286"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1344"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1365"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1479"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1489"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1515"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022095084.1"/>
        </source>
    </evidence>
    <sequence length="1760" mass="172329" checksum="6E4D14151706C025" modified="2022-01-19" version="1">MKYREVIERHVLVCCLLVLFVWTEWANAAACTGCVKDKCICNGTKGEKGDRGYIGLPGHVGQPGYPGPEGPIGPKGSKGDTGSSGAVGPKGYRGSQGVPGFPGSPGLPGLPGPEGPIGEPGTPGCNGTKGDPGRPGQPGTGPAGPQGPSGLMGPKGEPGEPAVNLPGNKGDRGSPGQPGRQGPPGLSGRDGSKGDRGPQGMSGEQGLLGPKGEKGPPGVGFYGQKGEPGNPGVPGPPGEPCGNGTRPVGGSNVSEIIPGDKGDRGNPGPRGERGEKGEKGYPGFQGLRGDDGMKGPKGEPGPTGRIGKRGKDGPPGPPGYEGERGPPGVPGAAGFNGPQGPKGDKGERGRPGLQGPPGESVDTPGIGNPGPRGPQGRDGPQGPPGPPGEKGARGLQGIEGRPGNPGPPGSPGQQGPPGIGEKGEQGPPGVPGPAGPFGPQGVAGREGPKGEPGMTGLSMQGPPGMDGIPGRLGNPGPPGPPGSTGPQGFPGIPGNIEGSIGPQGSPGPPGPEGEPGATGNPGPRGFPGRMGDTGEPCGPCPSGPQGMKGDPGPAGAPGRPGPQGFDGPQGSPGQQGLRGDPGVDGDPGINGPIGPSGPRGQKGDRGEPGPIIQGQRGEKGDKGERGFRGSDGSKGAKGLPGPRCTAPSNISSMLKGEKGEPGFQGDPGAAGLPGKQGIPGQRGASVLGNPGPPGPQGDRGDFGPRGPPGMKGEKGEPIFISEPGQVGPQGPRGPPGPPGDFGERGPPGPSGPTGTKGNRGFDGQKGEMGEQGPPGIGMPGESGEKGFRGLPGDRGPQGLSGPPGPDGLPGVEGTNGAKGETGTPGVPGVQGPRGLKGAIGPQGPPGARGAIGLPGENGEPGPLGPKGDKGDVGPRGPLGRPGEPGDIGVSIPGTDGPPGEDGRPGEPGPVGEVGPQGPQGPPGFAAIKGQKGEPGRPGRPGDLGLPGPTGETGEDGQAGQDGRPGEKGDRGPPGQSGQPGPPGEPGENGVPGAKGDQGSIGLPGVIGNRGPTGQKGARGEDGPEGQKGDKGFPGPSGQNGLPGQNGQPGLPGPPGEDGPAGADGSKGDRGLPGIDGQRGDIGLPGERGPPGMPGLEGRRGEKGQMGDMGDPGSRGEKGDIGREGLIGAPGPDGDPGIPGENGAPGLQGRAGPTGPKGVKGVPGPRGFQGEKGHVMTVPCNLEMKGAQGPVGEKGDRGDPGPNGLNGLKGDRGLRGFTGPPGPPGENGEQGETGPKGDRGQPGETGPQGPTGPKGDKGRDGTPGSPGIIGLPGNLGAKGDLGPMGPPGTNGNPGVNGEPGERGFPGIRGEKGAPGRPGEALTGPKGDQGPAGPIGRQGPPGNDGPPGESGSQGPPGQKGEQGIVGPPGPTPIVIPGPQGPPGEPGAIGVPGEKGETGPTGALGLPGRPGQRGMPGVNGEDGAQGEKGAVGSPGPKGEPAEPIDITLMKGAKGDIGPQGPRGNDGVPGQEGEPGNIGPRGPKGDKGDEGPRGNPGFNGRPGDQGDKGNKGFPGPAGPRGFPGEPGLNGLPGPPVLTGYFITRHSQTSQVPACPFGTNLMWEGYSLLYVQGNERAHGQDLGSAGSCLRRFTTMPFMFCNINNICHVASRNDYSYWLSTPEPMPMDMAPFSGDTLEPFISRCVVCEAPAHVIAVHSQSLDIPVCPQGWRGMWIGYSFMMHTGAGAEGSGQALSSPGSCLEDFRSSPFIECHGDGRCNYYATTYSFWLTTVDSDEQFSSPASETLKAGSLRTRISRCQVCMRDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPH6</accession>
    <name>A0A8B7YPH6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein C20orf24 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110981366</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094572.1">
        <property type="nucleotide sequence ID" value="XM_022238880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPH6"/>
    <dbReference type="GeneID" id="110981366"/>
    <dbReference type="KEGG" id="aplc:110981366"/>
    <dbReference type="OMA" id="ANSEWPD"/>
    <dbReference type="OrthoDB" id="286395at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010742">
        <property type="entry name" value="RCAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906:SF0">
        <property type="entry name" value="GEL COMPLEX SUBUNIT OPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12906">
        <property type="entry name" value="PROTEIN C20ORF24 RAB5-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022094572.1"/>
        </source>
    </evidence>
    <sequence length="125" mass="14383" checksum="CE099E251987CDD4" modified="2022-01-19" version="1">MATRRRKGDQEDTKQNLPSVWKRVFVSGSKWQEKDEFLDVIYWGRQLVAMLCGILWGIIPLKGFLGIALFCAANAGILYVYFTSFQGIDEEEYGGVWELTKEGFMSSFALFLVVWIIVYSALFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPN8</accession>
    <name>A0A8B7YPN8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroperoxy icosatetraenoate dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.152</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Hydroperoxy icosatetraenoate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110981402</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.152" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022094637.1">
        <property type="nucleotide sequence ID" value="XM_022238945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPN8"/>
    <dbReference type="GeneID" id="110981402"/>
    <dbReference type="KEGG" id="aplc:110981402"/>
    <dbReference type="OMA" id="FYICEQK"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11055">
        <property type="entry name" value="CYP3A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000042">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050705">
        <property type="entry name" value="Cytochrome_P450_3A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302:SF47">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24302">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 19 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 19 20" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="16 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 19 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="19">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00033404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022094637.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="59348" checksum="26E45CEA7F968DF3" modified="2022-01-19" version="1">MEEDISTLPSSGFGISWWYCIGTAAALLVGYNVWYYTQFIRSGIPGPLPIPFYANIKRSKEAFYICEQKWVAKYGKVMGFFSVGGPTLLIADVKMIKQLLVKNFSSFLNRGASQFVQSDRLRKMLIGLRGDQWRSTRHTILPMFTASKIKLMAHTLNECTEAVILQKLRESTKDGQTVEIKELYGAFSICCIGVAGFGLQLHSHSEDDESLTLAAFEKNAKDFFSRLKSTKWLLIEILQKYIPYAIIRYFDIGLVSQESENFFFDMSADLFKKRKEGRMQGDSVDFMQPMVNAHKDEDEEGWCQSSPMEMGMKKVKLSIDEVVAQCVMFLIAGYETTAACLIFASYLLACHPDVQEKLASEVRATIGGSGSHKVTFELISKMPYLDKVVIEALRLYPPIARVTRECTKDTSLQGMRIRKGTRFIVPIWTIHRDPELWPDPLTFNPDRFSAQNNCLNMDAFLSFGDGPRSCLGNRFALAEIKIALARILAEFKMQMAEDTPQTLELGKGVFLSPRHSVPLKFVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPS0</accession>
    <name>A0A8B7YPS0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">G-protein coupled receptor GRL101-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110981749</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095274.1">
        <property type="nucleotide sequence ID" value="XM_022239582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPS0"/>
    <dbReference type="GeneID" id="110981749"/>
    <dbReference type="KEGG" id="aplc:110981749"/>
    <dbReference type="OrthoDB" id="10113817at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372:SF77">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24372">
        <property type="entry name" value="GLYCOPROTEIN HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034208381" evidence="14">
        <location>
            <begin position="28"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="625"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="15">
        <location>
            <begin position="25"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="16">
        <location>
            <begin position="437"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022095274.1"/>
        </source>
    </evidence>
    <sequence length="770" mass="85498" checksum="3DA74E9F93F575A9" modified="2022-01-19" version="1">MIPVTMVKRHLSLDVLLFCILASLCHAKIPNGIHLITLTAKAPEWSFQSPNFNLGLYPNDFLGVWLIKVDSGSKVIFDFDVLEIDKGDLLEIGNGQDASDLASELDISVITRLTGNLSAEGVRLIAKGNEAWLKFRSNQDTTCRGFSVTVRMQDARRMQEEGFCKQDFQCARRVEGITCLGNESVCDGFEQCKDRSDEANCDSSRYDRSDISSCKICAANQQYDHENHACPTSLPDQQTCTRPSPLCGCGGRGKELGILCIGWYPAMLRTVPDETHSLFLSGINVNKLKNSPFKMFPNLRNLKVLVIQATSGASDLKRHAFDGFEGLTSLVIFDIHLRKIESKAFAGLDQLDTLAFFGKEATSDLPVIENGAFEDIADKLSYLFVDDYRFCCFFGATIQENCREWFDIPELFSCSQLVPNYVLKVFMWILGISAVVGNILVMVWRCREKVASRASLMINSFLVFNLASADALMGLYMLIIAGADAFYGSRYFEVSGEWRASAACKVAGFISMVANETSVFFLVFISITRFMFVVFPFVSNRHLSLKVVKVAGCIIWLLTVIIAVVSIVLSLDEESGAYGLSDVCIGLPLTTRVTGFEINQQRIDVGGIGEVTYSRPVPTSTSATWVFSIVLFLGVNLFCFCVILACYISIFVKVKVAASRVRSRSARDESEVRMAVKMAAIVLTDFSCWIPVIIMGILFQAGVAKNNPEIFVWSVVFILPINSSINPYLYTFLDICIKQKREQKVSKIAKKEEIEAKALPSNKTTSTTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPS8</accession>
    <name>A0A8B7YPS8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A</fullName>
            <ecNumber evidence="8">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110981423</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(1)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55392"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12415"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022094681.1">
        <property type="nucleotide sequence ID" value="XM_022238989.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094682.1">
        <property type="nucleotide sequence ID" value="XM_022238990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPS8"/>
    <dbReference type="GeneID" id="110981423"/>
    <dbReference type="KEGG" id="aplc:110981423"/>
    <dbReference type="CTD" id="115708"/>
    <dbReference type="OMA" id="PCIEQSL"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000247">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.20:FF:000002">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="64"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="249"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022094681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022094682.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="40978" checksum="4CDF9C9D32E2466D" modified="2022-01-19" version="1">MGFLGYSDVIRDGDKAIVYLGYNAMMPLKLSHGTVTQTRRGALRHSDIIGKKYGCRLSTLSGKGYVHLLQPTPELWTLNLPHRTQILYFADISLITLQLELKPGSVVVESGTGSGSVSHAFARTIAPSGHLHTFEFHEQRAQKAREDFEEHGISHLVTVAHRDVLEQGFGIDFTVDAVFLDLPCPWRALSHAKKILKRSGGKICSFSPCIEQVQRTCEELRSLGFSDISTLECLQRNFEHRTVTLPYPNLGKNTTGDGFKQTGPNVDDGCPPQDNVAVGTSMDGGQGERDTDAACRTSTPEAALPLNRQGETDQESDCNGGESRAKRPRLSEGATQDKKGASQSYPTKCAVPWKDMPGHTGFLTFATLYILPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YS24</accession>
    <name>A0A8B7YS24_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110982155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110982155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096083.1">
        <property type="nucleotide sequence ID" value="XM_022240391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YS24"/>
    <dbReference type="GeneID" id="110982155"/>
    <dbReference type="KEGG" id="aplc:110982155"/>
    <dbReference type="OMA" id="DPRRYCF"/>
    <dbReference type="OrthoDB" id="6041373at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051045">
        <property type="term" value="P:negative regulation of membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001820">
        <property type="entry name" value="TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844">
        <property type="entry name" value="METALLOPROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11844:SF33">
        <property type="entry name" value="TISSUE INHIBITOR OF METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00965">
        <property type="entry name" value="TIMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00206">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034646447" evidence="5">
        <location>
            <begin position="22"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="41"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601820-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022096083.1"/>
        </source>
    </evidence>
    <sequence length="286" mass="32422" checksum="7112047E7E65B742" modified="2022-01-19" version="1">MLHQTLSLALALSFWLLLASTVHISEESFFFVQKHPQEHFCEADFVLVGKVLSKTTSSLSLENYHRVNELLELRPPPNETIVLSVYVKRVFKGHAFAKEGNTVVLVTSRIKTDLEVVKRRSYIFTGFVHLANVPNDYGHCSSLLETGRHVFVENHLNFMWGCSWFQHRSLLTIKQKQGLLGMYARSCDCKIVKCHGRRNDPRRYCFGDVKRALFGDGCVLHHENQFQVVRLMTCSRHCGGRDDACRWVTCPLTRNQRPQGQTPTDGSSIEPVSTTSSPNATVGNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YS25</accession>
    <name>A0A8B7YS25_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC110982156</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110982156</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096084.1">
        <property type="nucleotide sequence ID" value="XM_022240392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982156"/>
    <dbReference type="KEGG" id="aplc:110982156"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000715">
        <property type="entry name" value="F-box protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001203">
        <property type="entry name" value="F-box/WD repeat-containing protein 1A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059081">
        <property type="entry name" value="PRRT3-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25987">
        <property type="entry name" value="PRRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="12">
        <location>
            <begin position="1177"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1274"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1316"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1362"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1402"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1442"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1487"/>
            <end position="1526"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="1527"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="599"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="731"/>
            <end position="758"/>
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    <feature type="region of interest" description="Disordered" evidence="10">
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            <begin position="802"/>
            <end position="825"/>
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            <begin position="866"/>
            <end position="890"/>
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        <location>
            <begin position="978"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1080"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
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            <begin position="610"/>
            <end position="620"/>
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            <begin position="677"/>
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            <begin position="805"/>
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        <location>
            <begin position="868"/>
            <end position="878"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
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            <dbReference type="RefSeq" id="XP_022096084.1"/>
        </source>
    </evidence>
    <sequence length="1561" mass="173859" checksum="C10AD2878A8F677A" modified="2022-01-19" version="1">MSGQFVLLLIKQREVMAPHHLYLAVVCVCLCWFHVQGTSSTQASVVPYNKMVSTTSPIIDRIIDGSVGKDSTAEPEPEPETEPEPEAEPSAEPEPTDIPELPPFAEPVPDWDEALPMYGIFWIIHIYILGSLFALLALYSFVSLIRLRSRRLLSRGYFVALNIMMLIMGLDRAIYLFVDAYNHKSIFPLPVAYMLLGMGFPCLSSAFSILFLALLHSTRTRLVSPKIQRAKVLASIIIFHFTVSIVVDVTVGLFTKAQVLLLLCQGVFLIWGLFLSISYLVIFRRLHKSSVRQFRELSRLSMSRRTSTLYGISPFVKKPRNNWGSAIKVTLFTSFFGVAIGLLQLYGILVVYGPLGEKVPEPWSWVWYQLAFRICELVMCILMSYVATQPFRYTVNGTEIPMCMCCTNICETIRGKKSHSLQEADSYRLVSGDASLPATDFGKGLEDGMLFDPQKPQHFHTSANLQLPVSNTFHQEPTQEPVKKSTFSNQVPEYEIVETNGTVADNNKKNLLKLEMANIPSSLNNSNKPASAPVSIEDNLWNDSTCSSPIIKTNRSFSDIKTYNHNKNNPHSCPSTPIRGQGDSAEIQLSGLNHSLSKLHNQSTDEEGPGQQTTDENSPLASRGKGVDLEAGERTGSGSSHDVPTETEPDIADATLVTEIAASLQIVGDQDMEGTRRGSSVSESTDLCSGMSGDVAHTQCKGIAMIDCRLRAICISLTHVPFHVEPEETQMDHADHPSYGGSSDSEGASARPPTKRAKSKAKVWEKVAWFTRRPRREPETDSVLTGEDGGAACLPLDVMDIDDVPSSSSSHSPNMSQPLSEYSSSSEGDIHVAAYGNTSKDAEDSQVVYQNCVRPSLVKAMFGKNQGRGRDRKLQSFKKEKKSTKRSTREFANDGDHFWTSKSIFDDKEINGIETKQPAATAEVEWDMKTLQCHCPACCSCRHSKSDVSFASWPRKRACPLQLSLRMAKAKLPMAVQLASAQAHSSPDQEVRDKKHHSHSACLPSSSEPLDKKRIQPPTDDLQPLESVPCCCNRTANHHNKSRSLPACVSLSSPSLHPHVTISQPSSPDHLTVCRKRDIRITKNHRPSSQGSKTASHEVPSRSRGGKAKPSSFNLGVEGAIFKHRMELIQLWFDEFSDQQKNTMIKRLVEQCDLPQMHMLSVTMAPILHQSCPHNCQDLLSWLPAQLSLRILSYLDPVSLCRCACVSRAWYELANEPTLWRNLCRLPKWALPKAEEEKQMINHISSYIHWKQAFAERYRLRRNWLKGLCSVRTFEGHTQGISCVQFDDTRIVSGSSDNTIKVWNIRTNSPWSVQTLVGHSGTVRCLHLQGSQLVSGSTDRTIKVWDLSMQNSWSSIACRVTMTGHEDTVRCLQVDDEKVVSGSYDKTLKVWDIRTGHCRHTLRGHTGAVLCLQFDTTKIVSGSADKTIKIWSLATGSCLRSLEGHRDAVTCLQFDASKIISGSLDRNLKFWELTTGLCTSTIDWAHSEGHTGVVRCLQADSWRVVSASDDRTLKVWNLETGERLVTLRHHTDGVTCLQFNNSKIVSGSYDKTVRLWDFSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YU56</accession>
    <name>A0A8B7YU56_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Carboxypeptidase B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110982245</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Extracellular metalloprotease that contributes to pathogenicity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096232.1">
        <property type="nucleotide sequence ID" value="XM_022240540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YU56"/>
    <dbReference type="GeneID" id="110982245"/>
    <dbReference type="KEGG" id="aplc:110982245"/>
    <dbReference type="OMA" id="ANGMMIT"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.340:FF:000002">
        <property type="entry name" value="Carboxypeptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000056">
        <property type="entry name" value="Zinc carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.340">
        <property type="entry name" value="Metallocarboxypeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036990">
        <property type="entry name" value="M14A-like_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003146">
        <property type="entry name" value="M14A_act_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02244">
        <property type="entry name" value="Propep_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034675110" evidence="15">
        <location>
            <begin position="22"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="16">
        <location>
            <begin position="119"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022096232.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="47311" checksum="35CA8CFE06ADE1AC" modified="2022-01-19" version="1">MRVLFILAVVVVVTGVKRYDGFKVLRVTPKDESDVAWIRKLELQSLVEIWNSLRRSNHPVDVMVTPANQVQVTGLLADRGLDYTVMIGDVQAQLDRQAVAPDTPPGASTAALADFQYDIYHTHDQIQQWVSDMATEHSIVSKFTLTQSYEGRDINGIKISTGVGDPNKPIVWFEGGIHAREWISPATVMFISKSLVEDYYNGVTNVVNILDGFDIHIVPSLNVDGYVYSHTDDRLWRKTRSDLLPEFGCIGADPNRNWPYEWGGRGATPWPCSLTFRGREPLSEVEIRAVVDYLTALRDSGREIKMFIDWHSYSQLWMAPWSYSAEAPLPPDADDQDLLAGAAITALESKHGTKYDKGGSARLLYEAAGASCDWAYATLGAKYSYVVELRDTGKFGFVLPPEQILPTGEESYAGIVAGLEYALTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUN5</accession>
    <name>A0A8B7YUN5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2'-5'-oligoadenylate synthase 1A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-5A synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097014.1">
        <property type="nucleotide sequence ID" value="XM_022241322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUN5"/>
    <dbReference type="GeneID" id="110982703"/>
    <dbReference type="KEGG" id="aplc:110982703"/>
    <dbReference type="OMA" id="MERAMIT"/>
    <dbReference type="OrthoDB" id="9978031at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001730">
        <property type="term" value="F:2'-5'-oligoadenylate synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.20">
        <property type="entry name" value="2'-5'-oligoadenylate synthetase 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018952">
        <property type="entry name" value="2-5-oligoAdlate_synth_1_dom2/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258">
        <property type="entry name" value="2-5 OLIGOADENYLATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11258:SF11">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10421">
        <property type="entry name" value="OAS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50152">
        <property type="entry name" value="25A_SYNTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2'-5'-oligoadenylate synthetase 1" evidence="2">
        <location>
            <begin position="177"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022097014.1"/>
        </source>
    </evidence>
    <sequence length="335" mass="38542" checksum="7C6E5EBA7319572B" modified="2022-01-19" version="1">MANPRQPWCLPPESLEVWYNEKLQEGTGSFNSYCREAVDNVVRALHRICSTDLVPFDVDRVIKSGSLGKGTVVKELSDVDLVAFVNPPHLQPIVDVGPQTYKYQLDVVLRDMVRALRQLQNVTDINNKGFLLKFKLTNIGPNRRSLSIDLMATSDCHLSDSRAKRKLFDAMLQQRADDRRYYSPAVIENQLEFVRDQPGALKALIRLVKYWAYQRLPDHLQKSYRLELITIHRWENAGSPLRFSKAQGLKDVLQVLSNMSQLQVYWERHYDASVAKKAISHFKMQRPIVLDPSEPTDNVCNLYMEGNNLQLMRAAATTTLQSRLLQNVFVRQGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVC6</accession>
    <name>A0A8B7YVC6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein sidekick-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022097253.1">
        <property type="nucleotide sequence ID" value="XM_022241561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVC6"/>
    <dbReference type="GeneID" id="110982841"/>
    <dbReference type="KEGG" id="aplc:110982841"/>
    <dbReference type="OMA" id="KPMEINA"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF9">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="103"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="199"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="9">
        <location>
            <begin position="295"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097253.1"/>
        </source>
    </evidence>
    <sequence length="554" mass="61325" checksum="95346F03CDAF5578" modified="2022-01-19" version="1">MLVCSTTQRAVDSTNVTVTWSPLPCADHYDVKYALSHKDGCEQINSLMYIYDHHCTCQESQTTINGLMPNSQYVVRIKAYVNGAYGPPATTQITTTSVAPTGPPTMVTTESTGQRNLTFTWSPPSCGGQGGTITEYVYELSNPNTGWNTSARISVEEVTINELLPFTNYTFRVTAKNSVGNGPFSEAVTSRTLEAVPTVPLNVHIQSMDNVSVILRWSVPDPPQGIITHYNVRYRRNREVKPMEINANVTQLMLRVTNLDASTTYFFQVQAVTSAGQGPWSEAINATTKIGVPGPVWNLNFTERTNTSVTLVWDPPLKPGGLITGYIVQQRILEKPYQPELSLPNTYEEVVDKATLSRTNLEPGTKYAFRVWAMNEMFTGAPSNVLALYTKPSAPPAPSQPTTYQEESTDSTVTISFAPLVSNNIYVSSYVIHVKKSASSSRPKREAFTPIRYEDSIDDYTAAEISKQNLTDKFVVGDNQTYGSYRNAPLQRGAEYQVRVGSVSKGSEDVGLPNALRWLISTKNIFFSIQCYNVSLNYGVITLSLRHIVRYNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVW1</accession>
    <name>A0A8B7YVW1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cone-rod homeobox protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110982495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096625.1">
        <property type="nucleotide sequence ID" value="XM_022240933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVW1"/>
    <dbReference type="GeneID" id="110982495"/>
    <dbReference type="KEGG" id="aplc:110982495"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050848">
        <property type="entry name" value="Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333">
        <property type="entry name" value="HOMEO BOX HB9 LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24333:SF5">
        <property type="entry name" value="VENT HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="199"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022096625.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="43095" checksum="6BF99A44BD87E377" modified="2022-01-19" version="1">MADMLNSLDTVSALADQSNFHTDRGHNSSNYTTNADGTPSCPSPRQAISTTYQPVISTGNVSVSTPFVSVSSKVDYFKMTTPQWMSWPMSQTMDPATVRRIMTPLHINTSFGNDYFSQYPHQGSVGAGDGLLKIATNVYSHKQSVEEPEHQVPSVTEQQPTSWPTMAVVPIISGRTVGVKRPASEEPVSEEFYLPKLKRRKGRTTFTKEQVDTMEAQFQTSMYLTTGARRELAKELMLEDNQVKTWFQNRRMRWKRQHPQVHVRSGKHPASCRSRTQVVKPLQGPPSQTNQLIVPTPPLVGSTPSAVTGSIKTFSSDDRPLTYPMLPSSLYDHGLMAPSAALQEEFCPAQALYSVPIYHRCPTGFDFHPWISANAGGPLAGAHCATRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW75</accession>
    <name>A0A8B7YW75_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine-rich repeat-containing protein 58-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110983020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097568.1">
        <property type="nucleotide sequence ID" value="XM_022241876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW75"/>
    <dbReference type="GeneID" id="110983020"/>
    <dbReference type="KEGG" id="aplc:110983020"/>
    <dbReference type="CTD" id="116064"/>
    <dbReference type="OMA" id="GLSQWFP"/>
    <dbReference type="OrthoDB" id="1053178at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022097568.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41477" checksum="3A32642DD2617ACB" modified="2022-01-19" version="1">MCRLRYVMEHSTRASVHGAAENVQLAKAVLSRKQLLEFPEDEFSGQEQKVNIIDLSRNSLSCLPKSISLYTNMIELDISNNRISRIPDEIVALKSLRSLICKNNRLDTGSIPKDFGKCVSLEVVNFSGNTMLDFPMQLTEIGTLKSVYLGGNRIRQLPPEIQNLQRLEILYLGGNQLTSIPVEVSSLPRLMCLVLSDNRIEAVPSELAQLRSLKSLSLHNNRITTLPPQIVSLGDLCELSLRGNPLVVRFVRDLTWQPPSLLELAGRSIKNRGIPYTTEGLPHSLIHYLDSAQHCLNPKCSGVYFTSRVEHIKFVDFCGKYRLPLMQYLCSPSCTSSSGSSNYSSSSYTSSSDTESEDEGAVPSNKLKKVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXY2</accession>
    <name>A0A8B7YXY2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RalBP1-associated Eps domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110983326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098199.1">
        <property type="nucleotide sequence ID" value="XM_022242507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXY2"/>
    <dbReference type="GeneID" id="110983326"/>
    <dbReference type="KEGG" id="aplc:110983326"/>
    <dbReference type="OMA" id="NEHEQRV"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF174">
        <property type="entry name" value="GH06923P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="323"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="356"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022098199.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="49340" checksum="FD00353AD20DC3C1" modified="2022-01-19" version="1">MDGSFLNPTEQQYYSSLFSTLDHENAGRVKTTEAQEFFLLSKLTPDVLQQVIEICGANRLGHFGRSQFYIALKLIAMAQNAIPLPVSKEMIGQGIEVPLPVFGMKQSSSAPSSQDPDDPGQMEFVNPAFIDNVPDRGFALSGKHPPTDWNVGQVIGMVGPQASPRGPVVFPQVEQVPTMSPTRPSNVHVPPNIAGSPPPSSPRDSSPFSETPAIISPPHPVGLERHQSLPSPISPREHRPMFDKQGSVPGYGPVTDEGWASFEKDRQGEIQATQPTQSLDNSLNNTQDTSWAKFPDSHGESGSHGNPSVHDGTEDVWLITPEQRVYYTKQFMTLQPDPNGLLSGADSKEFFEKSKLPTAELSKIWQLSDVNKDGTLSLAEFCTAMHLVVARKHKVELPEQLPSSLIPVIGPKQDEVLHPLQSTPARSVTQLGDIYGLSISCCSFPIIAISSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYA5</accession>
    <name>A0A8B7YYA5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LOW QUALITY PROTEIN: uncharacterized protein LOC110983392</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098324.1">
        <property type="nucleotide sequence ID" value="XM_022242632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983392"/>
    <dbReference type="KEGG" id="aplc:110983392"/>
    <dbReference type="OMA" id="ECVHANI"/>
    <dbReference type="OrthoDB" id="9946729at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029241">
        <property type="entry name" value="TSGA13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37352">
        <property type="entry name" value="TESTIS-SPECIFIC GENE 13 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37352:SF1">
        <property type="entry name" value="TESTIS-SPECIFIC GENE 13 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022098324.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="56608" checksum="372C5362E21B28F5" modified="2022-01-19" version="1">METDEPSSIREAKRQERRQMQEALTQRGKIDLESERQEARTKRRAARKLAAKLQQASLDSGDKQEQCTAPPAIGRTLSTIPSRGEHRSGRLSVVSSSDEDDKDEDGEHDREEVDKDTLPHQQDLYKIFGRKQANYFLRPXIEPEQKKVVPVPQSLRKQGGRAGVSALWGTLRDQSTVKLQKADSKIPQELKAAYGAFVRECLTNNKTVAKRSFYSEEGVPDGERLQDGSYHQRVKDVQKKVELMYRAAMTNEDKATVLLFNNPIPDFNNLKGTEGPLRYHPSWIDEGSDEEEPSYKKWLREMPSPHLQLPPLEDLPPTPAKQQRPSRNPQDQQDTDCYDANDNDDDSMSWDSLPDLPDEEQPPAAKDKKPQKLSFLTEAAATVPGQFRKRWEDKRDATGRFIPGKEVMARASLEDNGGGDGTKTKLAPGLSMVRSSTAPPLSSSLASQSSSGQRKIQTARKEWQPLSLTALEDYKPAVHLLGQGDFAQGQEFMWKPIVASAAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYX5</accession>
    <name>A0A8B7YYX5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 13-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110983543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022098549.1">
        <property type="nucleotide sequence ID" value="XM_022242857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYX5"/>
    <dbReference type="GeneID" id="110983543"/>
    <dbReference type="KEGG" id="aplc:110983543"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="78"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022098549.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="57025" checksum="AE2BB7457D4F3510" modified="2022-01-19" version="1">MLCVYIASSYVIPNGNGDKTFQSVIGICGFKVRFLCFCSHDYVSLEPRTPLCRQSVKRRRRGYMSSPGVAPDGGWGWFVLLAAHSTLIFREGIAKCLGVFLPTFRDVFGTSTSLIGMISSLCVTFADFTGLISGPLCQRFGCRPVAVVGGIFASSGLIIAAFFAQTTLQLSWLLAVAGIGLGLALTPSLVMISRYFDKRYSMANGLAYSGSGVGILTLAPLSQVLIDTYGWRGALSIIGAMCLHVTACGALLRPLRGYDHGKKDEEKHAIGRRYQRIPSNCDENGIDSCADTEEDTITPGAMGLSEPEKECKRSCCRSCCSSCWESSEGILGLSLFTEPPFVLLMVVQFCGRFTYMGWLIYLIPHAIEKGISPIDATFLASVAGVTNIIARASHGVLVDRKCLTATQLLAVAAILAAVSLLLDPVLNTFNTLTAASLAYGLASGIYFPISVVVVKEAVNPAKFANALGWSYGFAGVGRMLAGFVTGWLFDYFGNYDISFIVLGSIQLSAVFLLLVSCLIEYCRKSRKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z158</accession>
    <name>A0A8B7Z158_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 12">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110982787</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 12"/>
    <dbReference type="RefSeq" id="XP_022097151.1">
        <property type="nucleotide sequence ID" value="XM_022241459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z158"/>
    <dbReference type="GeneID" id="110982787"/>
    <dbReference type="KEGG" id="aplc:110982787"/>
    <dbReference type="CTD" id="7389"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="15">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022097151.1"/>
        </source>
    </evidence>
    <sequence length="426" mass="47724" checksum="D430DD42A95563AE" modified="2022-01-19" version="1">MTEKAPDINCDIQAPPAKKHHAIPIPQRLAPPVQNSEQIQAIFKALSDVRKKVKQLHNRQNFPPLKNDLILRAARGEKTERVPVWVMRQAGRYLPEFQATRKEHDFFEICQTPELSCEVTLQPIARFDLDAAIIFSDILVIPQVLGIHVEMISGKGLVFDNTLNCPEDLARLKSDVDVTEALSYVFDAITLTRRRLEGKVPLIGFSGAPWTLMGYCIEGTGNSTTLSKAKKWLYVYPEQSHKFLRLLTDKIVDYLVGQVLAGAQLLQVFDSNVGVLGYDLFMTFALPYLKEIVTRVKSTLRETNTEPVPMIVFAKGCHYAIEELSKTGYDVVSLDWTIHPEVARSQAASAVSLQGNLDPCAMYGSKDDIEGLVGKMLNRFGTQRYIANLGHGVYPDFDPEHVRTFIDTVHAQSEAINKRDAAGNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2H1</accession>
    <name>A0A8B7Z2H1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Collagen alpha-1(X) chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110983863</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022099172.1">
        <property type="nucleotide sequence ID" value="XM_022243480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z2H1"/>
    <dbReference type="GeneID" id="110983863"/>
    <dbReference type="KEGG" id="aplc:110983863"/>
    <dbReference type="OMA" id="WSITSAK"/>
    <dbReference type="OrthoDB" id="9889709at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF33">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="C1q" evidence="5">
        <location>
            <begin position="183"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022099172.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="32655" checksum="4F89230C7BA4D357" modified="2022-01-19" version="1">MVFTATNFRSVLTSPYGELRVEAAKQTLLSVSSYNLGPRRHCLKLVTQIRMELTRLLVLLWSITSAKVLSVNSTVTVETTSSTCCHCTHGVPGVPGIPAVPAPRGPMGPKGDPGTPGEAGTKGSKGDMGSDGSQGVPGERGESGVGVEGPPGERGLPGQRGLKGESGTPGPAGPMGPKGDACASIPQVAFTVARVTSYSSSGGHLTYDQNVFNTGADFDLPTGTFTCSVPGIYVFTFSVLKEPVAAEVYVHLFKNTERTVTAFARNSMYHQISSSSVMSLVANDQVYLQLFGQVHGTTANFTSFAGFLLYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3D4</accession>
    <name>A0A8B7Z3D4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein LOC110984004</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110984004</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099462.1">
        <property type="nucleotide sequence ID" value="XM_022243770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3D4"/>
    <dbReference type="GeneID" id="110984004"/>
    <dbReference type="KEGG" id="aplc:110984004"/>
    <dbReference type="OMA" id="TCVEFVY"/>
    <dbReference type="OrthoDB" id="4473401at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="Kunitz-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000020">
        <property type="entry name" value="Collagen, type VI, alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000699">
        <property type="entry name" value="Uncharacterized protein, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.75.10">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036645">
        <property type="entry name" value="Elafin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008197">
        <property type="entry name" value="WAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938">
        <property type="entry name" value="ACP24A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45938:SF11">
        <property type="entry name" value="WAP, KAZAL, IMMUNOGLOBULIN, KUNITZ AND NTR DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00095">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00217">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57256">
        <property type="entry name" value="Elafin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51390">
        <property type="entry name" value="WAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034265028" evidence="10">
        <location>
            <begin position="26"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="WAP" evidence="15">
        <location>
            <begin position="47"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="132"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="304"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="344"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="13">
        <location>
            <begin position="465"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="12">
        <location>
            <begin position="523"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="100"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022099462.1"/>
        </source>
    </evidence>
    <sequence length="666" mass="72785" checksum="800870C0E960A0A4" modified="2022-01-19" version="1">MKSHILQVSSVTCICLLVILLSVDGNPVEKAEGNARKDQDPKSGDIDLSKPGTCPSEQIVSKHSLAVCTLDCLFDLECSGTMRCCPDSCGGAACIETTENEDKSSTIQPATETITSPARASSESADSTTPEPTVSATIRTRTAEATASSDNNAESDLHLDGDAVVNVSVVVGKDLVLHCNISTTGSEPLLFFWMVQTDGGFLSWSDVTSTDNKRVSHGGAWLEILGATLQDSQSFVCFGGHSIGYLTQTYMVTVTEKPETSQGSPPDSCANDACMNGGSCIEEEDHTYHCVCPDGYQGEGCTEVLNPCGQHPNICQNGATCVAADSHFSCKCAPDWEGVLCQDRVSACRSSPCLNGGECVDLVDTFRCVCPPKFSGLRCKEKRPVTTETSREETTLPPTTVPMSDACYLPLDMGTCSRKETKWYYDTETEQCRPFVYNGCRGNANRFSSYDNCHWECPRLPADPCAHPIVTGRCKAMIPRWAYSAESRTCVEFVYGGCLPTGNNFLTREQCAQTCMSDTPQQCEVCNPPSLAMAYCNSDFVITGIVRRQLFADGTLKTVVLELTRRYKGHNLTLRRSKFLDEPIFIVKSRSQESDTCRNDCFKDLEDGKEYILTGTLSREGGSTTAHLTSKSYVKPVVGRRLTKLEMIKNDRAFNRRCSRRLETPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3P6</accession>
    <name>A0A8B7Z3P6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trithorax group protein osa-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110983213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022097981.1">
        <property type="nucleotide sequence ID" value="XM_022242289.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983213"/>
    <dbReference type="KEGG" id="aplc:110983213"/>
    <dbReference type="OrthoDB" id="8916892at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018862">
        <property type="entry name" value="eIF4E-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12269">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12269:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10477">
        <property type="entry name" value="EIF4E-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="739"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="831"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="901"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1204"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="855"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="908"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="945"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1012"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1101"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1208"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1252"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1293"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022097981.1"/>
        </source>
    </evidence>
    <sequence length="1354" mass="146490" checksum="5C1BD5165B30C928" modified="2022-01-19" version="1">MAAPFTCQQFKMFLWRMIKKSEPDGESGEKEEEGGGGEKTKKRSETPTKAKVVKWQYDADALHKLRYSPGTKKRPLCLAEEYCDDNGIWDPEKWHAALSGKRSRGPSPLTLQEGGRDRKKFPGDVKDRLKDDKDGIILSPQRRSFGHGCSVTTPLNTSLPAHLGANFSERGEGKEAVARSVPARRIGSGRIITRNRSLDQEESETRERREAGRYEDRGNQRVYSRRGSYGNADRSWRTPKQEEPEWFTEGPESQSDTIVLRGFSSKLLEDSDSDAETKEAGGPSVQNRNGSMETASSSSPDLSRERPETMPDARPNTPGKEFDINDFFKFADQIPMPMVASPEETERSGKSRFSHLFTSTVSRSRSNSNSRSNSRKSSLHEDELDFLNELTGRSSPALMSPASVFTPIKPTGDHALHHPHHQRPHHQPEVSGQTQQSLLHLLQSGQALPMQQGHSAPPGPVKSLAEIEAGLKQASLTPKQDRGRSTPPAVPLARQAGPPISGAGGGGGGVGDLFAMMGGQNKEDRTAFNRLVSSMRASGNLPAAKMPPPVEGRSLSPIEVQLLRQRLTPSPQPPAQQLYGPGQPSPHHSIRSTRDPAVAAAAANMAAMMAESQHQQQQQHGMMMGNQGRRPPAQGVPPTLLVPDIVNRIPSPIDQEVMATLMAQGTPSSQDRQPHLLKPTPTNQQEVMNALLQQASANPTLAAALRTPAGVAPQAGISPVGRVPSPAIPQDLLHQALLQQQQHTPRTPSPIAFGQQSPLPGGRSPIPFGLPGATSPLLPNARSPVIPASPTTTPIRPRVPSPQELAKHTQNILQQALIKRQLELQKEKFIARESARSKSPVPSIQGPGTLAGQMPASSAGQTPSPSAMSPQVQTKSMPKINATAFTPTSVIRKWHETRAEAKMASSAEAKKESDLKDADWKATDNLSGSPKHTPVRDKQAPSIQTPTVTLTTATPPRSSASSEPGVGGDSTGVDGSTSKQDGGLSPMHKARELQGGEPGEHHRTPPRPPMLQEENQITIQKQQQPQRMQEQQPTASHSSPSRHPAKHVEHQQQHQANQQQPGSDHSFAVDGRSRGPPRQPTRPSSHSPIPPGVGGHRGVSPRPPFGPGGLPPRMNPNMMGSPAAAQAQAQAQAAALAQATLLRGALFQQASGMPPPMRGGAPFPPMQQQAQTLPNMPPPMASMQMLLSQMNALPGANPMAALVAAGMQQKQQQQQQQPSQHRPPHANQQQFNQQDMFKHMPEMSVPQHQSHHLQQQQHHQQQQHQQQSHRPQHHPQFVSPPQSHNHIDDSGIGMNGGGGGGGIGDARHSPVNQLAKWFGADVLSKPLPQMGPVLPQGQKVMSVEELERQQQVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4S0</accession>
    <name>A0A8B7Z4S0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/nucleoside cotransporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983407</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098341.1">
        <property type="nucleotide sequence ID" value="XM_022242649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4S0"/>
    <dbReference type="GeneID" id="110983407"/>
    <dbReference type="KEGG" id="aplc:110983407"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005415">
        <property type="term" value="F:nucleoside:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018270">
        <property type="entry name" value="C_nuclsd_transpt_met_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00804">
        <property type="entry name" value="nupC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="214"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="295"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="398"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098341.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="68884" checksum="18074844D372A09A" modified="2022-01-19" version="1">MMNSDSTYLEEDGCGEKEAGPAETLPLRWEGLNSKSQARSSTDHAKIAIDLTELPPGPVGSDPEDVDVTDVAPRRQNGFNKRVEKVDKAIKGFIRSHRQPIKWAVYILLLLLFVAYVIAAVVLDFHRALALFVLSMLALAYATCRVIQHFCGARIVSGAVSCRQRKCGVFISERKLLITCLVYILFTALLIAMCALTGVIQSIVREPERLKSLFGLVCFLLLSFVLSKQPGLINWRTVFWGLWLQMFLAILILRTQPGFDSFNWLGKQVESFLNFTNAGAEFVFGPAPLSNHEILLTVLPVIIFTSSVFALMYYWGVMQTLIRGLAVIMQFTMDVSGAESFATASNIFVGMTVAPLAIKPYLNDMTESEMYAVIVGGFATIAGSVLALFIAFGISASHLLAASFMSAPAALVTAKMSLPETKAPKTASSANIKTAKALESNALEAMYVGAIDGLKICAYIIGNLVAIISVLAFINSALAWLGGLVDIENLSFQLICRYVLYPLAWLLGVDGADCLVVAELIGIKVFLNEIVAYNALAEYVDNEEISTRTQVIATYALCGFANLGSIGVMMGGLIPLVPHRKSEVSRLCVRALLASCVALFMTASIAGLLYDENQIYDPIPGGGGATPTVNATMKAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4S4</accession>
    <name>A0A8B7Z4S4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FACT complex subunit SPT16-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098346.1">
        <property type="nucleotide sequence ID" value="XM_022242654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4S4"/>
    <dbReference type="GeneID" id="110983411"/>
    <dbReference type="KEGG" id="aplc:110983411"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022098346.1"/>
        </source>
    </evidence>
    <sequence length="98" mass="11233" checksum="A11552F6A72DBEEC" modified="2022-01-19" version="1">MMEQGVANKWAALVESTEPDSDKFGLTEHDEDDSDVSRSTDSEVKTKSQRWHQYFISFLEDSSDSHSDSDEEQEQWMEKTANLGRPPCQVNALPWLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5X7</accession>
    <name>A0A8B7Z5X7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPI-anchored protein pfl2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110984812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101034.1">
        <property type="nucleotide sequence ID" value="XM_022245342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5X7"/>
    <dbReference type="GeneID" id="110984812"/>
    <dbReference type="KEGG" id="aplc:110984812"/>
    <dbReference type="OMA" id="CSHEACP"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022101034.1"/>
        </source>
    </evidence>
    <sequence length="844" mass="86279" checksum="13F0F5DBE53F3DC4" modified="2022-01-19" version="1">MADVTTADTQTTTAQPSTPAAVTSLVAETTVADVTTETQTTTVKRTTAAVEPTVVETTAGDFSTTETQTTSGGFPTTTAIEKTTIGVSTPSVSTGYSTDTSTLAVTATELETTLTVATATETQTETVVPTAVAAEITTVERATTQTQITTAQPTAAVVESTAQVQTTAANLTSIETQTTTNQPKTAETLETTVADITSTETETTVAEATTTAAETTVADITSTEKVTTTGRLTTEVVETTTAVETTISNVTTREKQTTTDQPTTAAAQKTVVETTVADITTAKTLTSTTPPTTGAVETTVIETTAAGLTTAQTLTTTITATTVPAETTVVQTKVADVTTAETQRTSAKPSTAAAETTVVETTVAGLTTAQTQITTEQRTTSAAETTVVETTVADVSTPGKETTPFKGTTAAVETTIRVDTTVANATTAETQKTTAKPSTGAGETTVVETTVADLTTAQTHITTEQRTTAAAETTVVETTVPDVTTLGKETIRFEGTTAAVETTIRVDTTVANSTTAETQITTEQQTTAAAETTVVETTVADVTTLGKETTRFEGTTAAGQTTMKVDTTVSNATTAETQRTTAKPSTGAGETTVVETTVADFTTAQTQITTEQRTTTAAETTVVETTVADVTTAETQTTTAQPSTGAVVATVVETTVADLTTAQTQTTTIVATTGGAETAVVETTVADLSTPGKETTPFEGTTVAGETTIRVDTTVADATTAQIQRTTAQPSTGAAETKVADFTAAQTQTTRVLATTEPVETIAVNITTTETVTTTVEPTTGAVETSTVVDTTVAAITSLEPKTASLEGTTGSSSITTLAGVTTGSSGLRIFRLFPFITNIIFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7Y6</accession>
    <name>A0A8B7Z7Y6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polyadenylate-binding protein-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110985221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022101773.1">
        <property type="nucleotide sequence ID" value="XM_022246081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7Y6"/>
    <dbReference type="GeneID" id="110985221"/>
    <dbReference type="KEGG" id="aplc:110985221"/>
    <dbReference type="OMA" id="CYLSHAL"/>
    <dbReference type="OrthoDB" id="8171816at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008494">
        <property type="term" value="F:translation activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000016">
        <property type="entry name" value="polyadenylate-binding protein-interacting protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051367">
        <property type="entry name" value="mRNA_TranslReg/HistoneTransl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254">
        <property type="entry name" value="EIF4G DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23254:SF15">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MIF4G" evidence="6">
        <location>
            <begin position="77"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022101773.1"/>
        </source>
    </evidence>
    <sequence length="438" mass="48381" checksum="596BE150FE49A895" modified="2022-01-19" version="1">MKSLSADAPAFVPGTAWEGHPAQPQQQWSDSGPAEFVPGKPWPGVNGAPAPQPQQWSNGSEQPPYFNSSTEPDFVTMVKDVLFSLSVSPGLFEDYMKSMVEHLNAAVRSNKDLGLIADIIFEQSVLEPNFRYTGARACDYLISHLELPPAITKFRSHINQRVKEAVESREAMARDPNKLTRLHGATMFLAELFLISEVHVPEAKGPQRIDVYRVALSELMDTLLNSASDENLKCLGLLLKLSGKEIEDYDREQNNKTSSEQLSKIFLKARQYVTNQAVDKNVRELWLQLIELRAKRWGQGSGASYSGSTTAPPPAGSSGYMSGGGDTAPAMFSNQPVFYDSQGKVISAAEAGFGDEYDGDLENWAYYQTTEDDGSADPYTDYAPSSTADPYAEYDWDPSHYQQEPAAELDYADDLDELDAEIQKAFSDFLIETGQGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8L6</accession>
    <name>A0A8B7Z8L6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110985345</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110985345</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102003.1">
        <property type="nucleotide sequence ID" value="XM_022246311.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102004.1">
        <property type="nucleotide sequence ID" value="XM_022246312.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985345"/>
    <dbReference type="KEGG" id="aplc:110985345"/>
    <dbReference type="OMA" id="WANINDT"/>
    <dbReference type="OrthoDB" id="6061841at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665673" evidence="1">
        <location>
            <begin position="30"/>
            <end position="2862"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1089"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1716"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1826"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="1945"/>
            <end position="2031"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="2169"/>
            <end position="2250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022102004.1"/>
        </source>
    </evidence>
    <sequence length="2862" mass="313457" checksum="6D49CC9F6F501AB0" modified="2022-01-19" version="1">MFLRVHTLIAVHFMVILFVARLPCSRALACSYKCQQRYYTSCWDITGFFSCTRHREIDCYRCCDGWTGTVSGTTGCDTPICHGHVNYCPNGGTCSTPDNCINCNPGYYSPRCDECTRISFCDSVTCTTSHNQICQSCNGDYGTSFGAAYKPSSDRTQCIKQCSWRSDSNACFPGSCADYAQCTCCSGFSGPDCRTLGSSQAPVLSEHRATLIMGTTTLESPRDQGSTATVYTNVRDFERIRINWESSYMVNNLFTASCSTNHAYVHSYGLGIVSARATAVVNRAQGGTHTVGSQSSSGAGSQLSPRTDFVISELEFSIDYASWTPATGDVLRYDVYSSNGGFLKLHNRDNAGTFYTRYYSGRTTSGYSTFTFDFVDPYHCVDVSSGCRSTMLNAGDDVTSQATTSISWQGWADDLAGIKEYELQVRQLSGTHGSEMTEIFDSSAVYQGVTTSGHSVTFPHVGVYSIILDVVDNAGNVKRSRRFVFFDDDPDDVTTRSDAPLRVVSATPETSYKWLTSLDSSGGTTSVRLDWTNHFTNVRHHSEGLLKGIGYYLNDHGSIESSYDQNFGQRGRESIPNALGVTQFRAFRDIDHSGGRTTVTVSDDDSDNWSNEGTSTQATYDLSLVDGDSVRFWVEARDLAGDFVRDSVLVHADSSPPIIEDLWLVRDGEVNLAVHNSADLHEMSVTFRTYDIHSGVRTIEWRLFDNYTGTEMEHGRQTVPARKINADTEDCDPVSCMCIPIGDVIGDCYAVDYGFNPTFHIGVHDYDYFITLTVTNEARLVTTQTIKVTVDTSAPQAGVVHDGIRGSNEVDFQEGSILSAHWEGFFDRESGVKFYQYLFDSSCWNDTTMIGTVKDRMTRTTSTHASWTAPSPGLYYVTVIAYNRALEPSEPVCSDGVVIDTSPPELSQIALGYARMWPGLAKDAEGRVWFINEHRRKTEVLNASSGCSSKAVFLDDLSVYPEMAGTNDSTSVLQGDLDCLWIWATEQKFFLPTHKHVTISWTGEDAESSIYDYEIGLSSQPSNPVPDQPSDPTPDLVTFTSTSGHDHFVMYHPHISHGSVFYLVLKATNKAQLASFKVIGPIVVDTTPPMFVGNVFVRVDDEYLIAEWGDDGFIDDEDTSLRYQVAIGSSPGGTETLPYQLERDYKIGPCLSRTLCAAFLLDGLDWHIQGDHEYYVSIRAQNGAGLSTVGTSSVYRHIVQLPSLGVVLDVAPPQEAVIVNLGVAKDIDVQMDTTSISARWFGFEHPHLEVSYDIAVGSERGSSDVSGSFISVGNATFYQLDGLDLTPLTSYYVTVLANSEVGNVSVTSDGVKVIPKGQILEGAVVKDGLGCDEQSGPLPSGLSHHSSAADSPCQDDISYQASTSDISARWTIPEMLQPFVTNVLLTIEQEVEVYFGEGNTTMVWIPLLDDQDLGMTFQHVASSMGLHAGAHYRSKIQFCHTVVCFQPIVTDGFWVLSQPPEVGQVAVSNIVTTQSKTEIQVGFQPFAHDYVRPDDPQELMDFYEWSIAEDGSDGALPSQWTRIEDLLVTRETALFTASLSGSLDLDVCLRLSVRGYNKAGLSSIASAEIVDCDDVTLIVPHLVIDADHEVKVEQNALWPEPDKNYILSTSLLSAVWPTLRHRAYVWAAIEDTGSADFGNLDNGLQYPCDHPRAKACGKTDKEFVNVPNLSLEHGMRYRICIHADEVTLEHELWKEELPAVSSCSDGVVVDTTPPTPGPVWIGWSQHRTYQSSSSELVLRWESFTDIEEHGLARHHSGIKYYEYAVGSMQGGSDVKEFTRVGISNSAILHNLRLQSGHMYYATIRATDFVGLSSQATSEPVFIDTSPPVVSALHTLDIGGSFIRSTTSVSASWENIFADEESGIAYYEWAVGSHPGHADVMPFTRQTSVSGVSDSSRPLLLQEGHSYFVSVKAVNKVGLTTLKSYGAFVVDASPPIAGHVFDGSLANAPSNHKDGDFQEDRTVIKAFWEGFHDPHSAILGYSCRAGTCPGCGDVVPEQHVGLDTDALIENLNLIPGLTYFVTVTACNAADLCISVTSDGVMVDDSPPVPGRVYDGGPGGGDINYQSSRLQLRAHWWGFHDPHSGLSHYEWRAGTTPGAADILPSTRIELSEDALRFLPASDQLPVGTDIYITVRAYNRLVMWIEATSNGFRVDSSPPDVVDAPAVDETQGMAVRNTLVFCDLIRFSWKFSDPESGVKDQFVSVSTHHSGDINIPPIKIAGSELDHTFTNLTLHEGSLYTITVVACNYAGLCTKAETEPVLVDGSPPSVGTFAVGTESAANLERHHIIWIDPTEPAKLSTTLDRSDFTTNAPPSPPRHHSGWMTWLEDTSTSTGSLALAWLGFADVHSGVSHYLVSVGRTYGGSELTPSGPFRVSQNNDGIPLDEGIVQGAVIPLEGSITGHSHPYLFISIWAVNRVGLPSKRHHSTFEASPTLPGEGALVLMRRCSPATCEGHCACAPIDRVCATSPGSCVDFSNSNPNHEIEVLDVLSLMSFNDTDPVNDIDDTATQHMMAAVWRVTEQKGLDVKWYEWSVGDDSNSSATEPAGVFDPARERIWFDVGQDNHAVITFDKDRKLFAGLRYHVFIRAWYDANAYAVFRSDGVTPDIKPPKISTVRGKKVKDLARSDSRKDTDYITEPSIISISWEGVFLDSVMSHYQVSLSTYPGGEDVRQFADHTFPASVYSTQFSSLNLLRGQRYYSNVRAFNKAGLHTLRSSDGFVVDRRGPDPGLVFDGIDLHDLEYQNSSAVISASWHGFVDLESYIDHYEWCVGQTPGPADDDILPCTNVGINLSVTRALAVPLTEGVRYYSKISATDAAGLQSLTVTSDGFVVDVTPPLPEECVLLGDNLIQNPSFEGMQKLLTQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZA22</accession>
    <name>A0A8B7ZA22_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110985243</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110985243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101817.1">
        <property type="nucleotide sequence ID" value="XM_022246125.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101818.1">
        <property type="nucleotide sequence ID" value="XM_022246126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZA22"/>
    <dbReference type="GeneID" id="110985243"/>
    <dbReference type="KEGG" id="aplc:110985243"/>
    <dbReference type="OMA" id="SEWQYLA"/>
    <dbReference type="OrthoDB" id="10356724at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022101817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022101818.1"/>
        </source>
    </evidence>
    <sequence length="507" mass="57865" checksum="C7BE29B0DAF5097D" modified="2022-01-19" version="1">MKTENSQTQEKWNSNPCFTMDLYTDSEESGSMTDISTTSSTMDNLRTPDSITKTNPFNFNDSKTYGVITNMNVPQSKMGIKSLSTYELQRQSNIRPTPDSLLDHTLLHPSPGHHSMTNLGTENIQRTSYNMATMSHDRLKNAHRGAGKRRHASVTSNLETDACTCGLTKHSDTNSNISCDTGNMQTHEKVQNRNEHLDLRPIQRNSPYPLWKFSKSKKPPETVLDVAYRTILDYKHPVTLHRQPKADRQMDHYDYLPSIKVFSEEDHQKREAMRFQLKYQLQMEEKRKRQEILEMERDILPESEREENVQKSIFLPSGEEYEFSDGDISTATLPVPSPRGERRSSTSSHHSSRSIHKPNSPRPVSSRRSSHDIHVSPAKSPPYTVSVMPPPSPSSQGSKRRHSVSTLVRRQKMFNVVSHWPGMGPNTKLYEIEEPSTQIISEEDSNSEMPKPPPIHHTTNRGSPVRQTNHATPVNHAHHRSRNSRMLSHTEHKTVQKGAPSLTREML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBR2</accession>
    <name>A0A8B7ZBR2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Guanine nucleotide-binding protein G(O) subunit alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110985594</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102416.1">
        <property type="nucleotide sequence ID" value="XM_022246724.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102417.1">
        <property type="nucleotide sequence ID" value="XM_022246725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBR2"/>
    <dbReference type="GeneID" id="110985594"/>
    <dbReference type="KEGG" id="aplc:110985594"/>
    <dbReference type="OMA" id="DDIVFRM"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000563">
        <property type="entry name" value="Guanine nucleotide-binding protein alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF231">
        <property type="entry name" value="GUANINE NUCLEOTIDE BINDING PROTEIN (G PROTEIN) ALPHA V1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="153"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022102416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022102417.1"/>
        </source>
    </evidence>
    <sequence length="359" mass="41772" checksum="6CE827C280D2B3E4" modified="2022-01-19" version="1">MGACIGVDQEEKRARLHSEAIDRQLIQMSKEEEHIVKILLLGAGESGKSTLVKQMKIIHSDGFTNHELMSFKPAVLDNLLSSMKYVLNGMGLLRIPLANPRNKIYAQTILQCHRCFDEQVKMRTSIAIALRALWNDTGIRACVARGHEFELNDSALYYFENMERITSEYYRPSTVDVLRARVRTTGVIETHFKIKGVIFRMYDVGGQRSERRKWIQCFDDVKALLYVTALSGYDMTLFEDPEVNRLRESLHLFESVCNNCFFRNTTIILFLNKVDLFRQKILHTERQLRLYFPEYPGPDYDVETACRFLRRRFQDANHNPKKHIYPHFTTATDTTNVEVVFQIVMETIIRENLKTAGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBY7</accession>
    <name>A0A8B7ZBY7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110985637</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102487.1">
        <property type="nucleotide sequence ID" value="XM_022246795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBY7"/>
    <dbReference type="GeneID" id="110985637"/>
    <dbReference type="KEGG" id="aplc:110985637"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040311">
        <property type="entry name" value="CCDC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31663">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31663:SF6">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034319833" evidence="2">
        <location>
            <begin position="32"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102487.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="26915" checksum="4055D6EFEE8B2F27" modified="2022-01-19" version="1">MHFILVNDVSFQLVLMAGLVAGCMNPPDWQAQDFQTRSQEADFIILGRVVGLTPMPEEGDPPMSLGFTAAIDVQCVYKTPTNDAGIASSITVTPVNFTMSCAKTVLSEERVYLVFLRKSAGSGDFMPDEVNREEAQFSPDAAKLEYLVATYGAGKDSRSPGCPKTDATGDGNSDGPVGGRNDSHILRGDGGVTQAPTNQHSPIKTDVTDPRNGSDKSMVMSIHVLVDVLTLKRHAWLGQSAGDDPTRGHCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCN6</accession>
    <name>A0A8B7ZCN6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102600.1">
        <property type="nucleotide sequence ID" value="XM_022246908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCN6"/>
    <dbReference type="GeneID" id="110985696"/>
    <dbReference type="KEGG" id="aplc:110985696"/>
    <dbReference type="OMA" id="MDCLPGI"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="186"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102600.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="44612" checksum="6265AE126EFA1931" modified="2022-01-19" version="1">MSSNSSPNSADVKNLIELAESKIDSSAERLNDLSLDIWNHPETNFKESHAHKVLTDFLENEGFMVERHFVLETAFRATFGCDDTGPNICIMCEYDALPGIGHACGHNLIAEAGVAAGIGVKATLQARGNKYGKVTVLGTPAEEGGGGKKFLIDAGAFDDVTVAMMVHPSKYNILRPIYLSMAILVIKYDGYAAHAAAVPWEGVNALDAAVMCYNAIYAMRQQMKPTWRIHTIITNGGAAVNVIPDKAELTCNIRALDEADLNILKKKLIACAEGAAATSGCKVEWEQSSSFASLISNNQLISLYEKHAKNLGWSCDLNLPAGTKMTGSSDVGNVSYVVPTIHPEYKICDGASYHTPDFTAQTGACRAQAPTLNQGKTLAFIAIELLHPSGQETLDKIRQEFEEKVNTLSPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDM1</accession>
    <name>A0A8B7ZDM1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Coiled-coil domain-containing protein 171-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985851</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102940.1">
        <property type="nucleotide sequence ID" value="XM_022247248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985851"/>
    <dbReference type="KEGG" id="aplc:110985851"/>
    <dbReference type="CTD" id="203238"/>
    <dbReference type="OMA" id="CRRFECD"/>
    <dbReference type="OrthoDB" id="287623at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37476">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37476:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 171"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="154"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="460"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="716"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1344"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022102940.1"/>
        </source>
    </evidence>
    <sequence length="1358" mass="155112" checksum="19E8D167FC2CA45C" modified="2022-01-19" version="1">MHPIKSSTTTYNHDTMATKSPQGTSVMTGEMSARESDVRRKSSPFLDDSEAAEELRQLRLKIARLQDENQSEIDMNNELRKRVTQLENEKLKLTASSNEEVNQLEAQVARLRAQFERGEAARQQLEYEIAVAKRGISQEKSLAGEREDSLNAILETHKEKISELTSKVQDLQSSLVSQRRFADETDVKLRTSLEEKERELQAARAEQDVIRSEKEQLEQVFHEQENIYAETQEKVNDLKTERDTQTNTVRQQLRELQYAAEREDRLKKEVEVTIGRIKTLEETIEAERAAHLESKFNSELVQLQVRDLKGALDVEKSAHAEVEHNAEIMTKQLRDLEVRLEEERSSASNAKHQAESFSRENELLKQQLGAETNSKTSIITNMSAQLEIHQKNFDELKQELSKAKKRQIYLEETYGGSMQELELLLHNFQLNGDKITSKKLAKGKKGDAKNKENLSPMLVLETLRHTLTDYQKRLDTTSQELTKMKSRSEKMAAECEKYREVTWTRSQTMQDLQKKFSSSYKEVEQLRHQLSESESQVTSLKMELQQATHRGEMEGTKAADRMEEFERRLKENQDEEEKRRIYLHSLYQRIMAGRVVLDPKEPVLSSFAWDELSIAVQDQVVGLMTGLTRANEKVAHLETVIHNKDELLREVQHAHEESLERLSVKGKEREKEWRRQRSQLEEQFSQQLADLHIKSQKTQNLADQAWEKARLTGAVKQGLEAECSQLGDQLTQATRERSGLLIGCCLLAGALLPMFSRVNQLAAQRTSLEEQIHSLETMRQQARELANTLSMEEADLGKDLRDISQSARNPVMLFRKAVIVVLAANRLNHLGLRSCGIFTAVDNPSGIHSVPVCSGNIKPSQRPFMGLKSSPDKQTQRSNVQSQIPDWFTSSALLTTVVDSCMELQELLTDKEQLNGSQPQTINNTAKSCFVRLMSKLTPIFEASCPHPSRRSYGKRDKGMLIRLLGYGLSQGMAHSSPAGKTHMASSQEIMACLQRNIINFTQRLHTAEVERRSLRVETAKLRQDNEELKMEKERAKDMENEITQLRDIRHNMVMKEKFDSVCQELSKALSREQQAQELLNEQSRQLEELGMRLNMYTTEELEKDATITEAVKGLSEAKMELRRKEQSIHQLSKKLSLLEEEKKSLQGSVQDVQEVLRSSNKEKDKLAGYLQAVQGAVEDIKRHLVSRADNRSVDAALRQVLIHPEKRGLDGISAEVIAIKSLVAAFVDTVQTSLSRLVALETEITSHKQHTATLKEELNAACLRAYPDDGQEQVRDDFMGQGSSRIPERSFGRSRPLYETDRSYKEQFVPLREEPDFSMMTQEGASGMKTSLYTPQTPLATSTRRKTPSKARNFNHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDZ0</accession>
    <name>A0A8B7ZDZ0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDAN1-interacting nuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110986371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103883.1">
        <property type="nucleotide sequence ID" value="XM_022248191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDZ0"/>
    <dbReference type="GeneID" id="110986371"/>
    <dbReference type="KEGG" id="aplc:110986371"/>
    <dbReference type="CTD" id="84529"/>
    <dbReference type="OMA" id="CYWNRFG"/>
    <dbReference type="OrthoDB" id="1272at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029404">
        <property type="entry name" value="CDIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661:SF1">
        <property type="entry name" value="CDAN1-INTERACTING NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31661">
        <property type="entry name" value="SIMILAR TO CDNA SEQUENCE BC052040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14811">
        <property type="entry name" value="TPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103883.1"/>
        </source>
    </evidence>
    <sequence length="287" mass="32752" checksum="D772767D9455825B" modified="2022-01-19" version="1">MKLVEYKKIVECLETACCDGTKESLVLVQQQFPSLSYHTLISIHSQRVQVKTKKQHGRHSSVAAMEAYYVRYQKQVADRSCRQGTVLLGLAREIDLSPALLARIILERHLFHSSGDGVAVPKTRVTKMLREPYLIEDPVLSMEVQQCVLWDSSYGPLVDSIKHSIGVELEVHLKKTLKEHGLAFLGEEEMRRKGYDKTPDVKLQVPIAIGGRVVNWIESKASFGDKHSHENYMRDQFWSYVNRFGSGLVIYWFGFIEEFATSSEQGIILADDFPRNFTKIDSWDGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEA1</accession>
    <name>A0A8B7ZEA1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Probable muscarinic acetylcholine receptor gar-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110986428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103969.1">
        <property type="nucleotide sequence ID" value="XM_022248277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEA1"/>
    <dbReference type="GeneID" id="110986428"/>
    <dbReference type="KEGG" id="aplc:110986428"/>
    <dbReference type="OMA" id="FWSITSP"/>
    <dbReference type="OrthoDB" id="10026056at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF204">
        <property type="entry name" value="HISTAMINE H1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="740"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="775"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="82"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022103969.1"/>
        </source>
    </evidence>
    <sequence length="827" mass="90597" checksum="A38100CE4D825DC4" modified="2022-01-19" version="1">MAGEIIANDSVPSNFELAIGASVNADGYNLSLATAVSLSCGSGLSGNGVSILQIDPDTDGYTPVVISLSFLVALLSFGTVLSNALIIHVIRADRTLHTVSNCFAMSLATADLLVGLLVVPFYALDVHVSDRWHEHIPAHSVWVTLDFLLTSSSILNLVLLNLDRFWSITSPMKYMRQRTKRRALLLIALVWGLAIVLTMVPVAIWPYAFKDVLVPTKTRFVCFGSSGWLMAASAVCIYFIPLTLLCAIYSRIFRAIHRRHKMDLGRSSIASNMSNRFGGSKRGSDMNQHGFISEQELQRLRNIYEKAICRERGERHLTAMVRKKKGYSPGTHLKRYESIDEEKEGVNESCENDPFSSETGDSQGTFNSRPHHQTKVGVTNMVNTLHVARSADDIFHGRITKSPASPFEGLGVLPKIKVPRILAGIEASMDVIRERDGSWCSSKSNKSLASEDKKAADNGSSHSQEMIGTVSPRRKNSSPTLGLMSSSPKERSPTGSNHLSIGGAADPINNFLQVLSPDVPIDVQKRWSSPPICVDEPGSEPDDTDQTPEDAIAAEENEDDDDNDMDPLQDLAAAVKRKRADSGEGALARLRANSSEMIRRASPRLARKEEAGDTESLLTVQRKTSGSAGSFYRDSFQSNRLLNQRRQNTRASYSLDVITGPRSDSGYASDCGFRRPGSLGVTVTKKERRASLSFPIDSVTMGALTSRVRTSVSNSFSAISGRGTKALTLLKKQDKAAKQLGFILACLVACWTPYFLQVLIYAFCSECGDVTAMTIAVFLGYTHSLCNPILFALFNPRFQRACKRNLFPCRSREETPRGIPVVPPSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEI7</accession>
    <name>A0A8B7ZEI7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Armadillo repeat-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC110986007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103270.1">
        <property type="nucleotide sequence ID" value="XM_022247578.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103271.1">
        <property type="nucleotide sequence ID" value="XM_022247579.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103272.1">
        <property type="nucleotide sequence ID" value="XM_022247580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEI7"/>
    <dbReference type="GeneID" id="110986007"/>
    <dbReference type="KEGG" id="aplc:110986007"/>
    <dbReference type="CTD" id="219681"/>
    <dbReference type="OMA" id="LYPMQSR"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055445">
        <property type="entry name" value="ARM_ARMC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052441">
        <property type="entry name" value="Armadillo-Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055164">
        <property type="entry name" value="EDR1/CTR1/ARMC3-like_pept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24768">
        <property type="entry name" value="ARM_ARMC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14381">
        <property type="entry name" value="EDR1_CTR1_ARMC3_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ARMC5-like ARM-repeats" evidence="5">
        <location>
            <begin position="254"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="358"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="400"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="2">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="EDR1/CTR1/ARMC3-like peptidase-like" evidence="4">
        <location>
            <begin position="692"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022103271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022103272.1"/>
        </source>
    </evidence>
    <sequence length="844" mass="92664" checksum="FCFD8AC46E2F5D1A" modified="2022-01-19" version="1">MGKKNKKETEAPPKDIFDPLSVESKKAATVVLMLDSTEDDILIKSCEALYKFAEKCEENKALLMEMGAVPSLLKLITSEEKTVRRNATMTLGVMSAHPEVRRVLRKGDCIGNVIKLLSSEEETLVHEFASLCLASMAQEFTSKVQILEQDGLEPLIMLLADSDPDVQKNSVEAIFLLLQDYQTRTAIRELHGLESLLELLKSEYPSIQEMALRCLALCTLDVENREALREVEGLERLVEFVSTKEWEDLHVHALLVLSNCLEDLETMELIQNTGGLQKLLAFTTESPTPDVQMHAAKAIARAARNGENCKIFHEQEAEKTLISLLETSDNSQVMGAAAQALGIMAQSPICRVTIAEYDGIAPLIKLLNNHNGEAVESASLALANLTVAQMANCVEVADHNGVEPLIGLLGSSSREGAQANAAMVLTNMATDEILREDIQRRGVVGALVPPLLSTNTTVQSKAALALAAFVCDADSRNQLRGLGGLSPLLKLLQSGNDDVRRSASWAIVVCATDPLIATELCKLGGLDILKEIQLSSTRQNSFSDAALEKLLDSTLPAKYALMGVLGPNDIIQDGFYDAGRVRPDGKFLTLEELSKQEVDQKRPVLLINCGSTNASPPRSPAPATNSSELDVKTDTSRTNIGSKSSKSAIRGGKRETKKEKEERELRERLEAERLAEQEAILAQQPPNFEPPADPKLEEYITEMLVNAAGLPTTREQLDVVARFVSDKMGGPIERGQLSSFSYELSLSQLKYELKSNVLPIGRIEKGIHYHRALLFKTLCDRIGVACSLVRGDYNRAWNEVLLIDEDDNPVKPKFPPKSYIVDLIHHPGRLMRTDSIDAANYQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF01</accession>
    <name>A0A8B7ZF01_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110986561</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110986561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104214.1">
        <property type="nucleotide sequence ID" value="XM_022248522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZF01"/>
    <dbReference type="GeneID" id="110986561"/>
    <dbReference type="KEGG" id="aplc:110986561"/>
    <dbReference type="OrthoDB" id="5986535at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022104214.1"/>
        </source>
    </evidence>
    <sequence length="129" mass="14466" checksum="8B9F2A7626694E93" modified="2022-01-19" version="1">MTKAFLTLNLAKINQEPDVLDIIRAFRQVVVEGRTLNCTNEATDDYEGDTYDIMISRSDIFNSMVDEFSAPTHNARLPLKVDFMGDRGHDLGGPERSSCASPWHKYLNGLHPVQTTPENLIAPMYPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF04</accession>
    <name>A0A8B7ZF04_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110986102</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
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            <taxon>Valvatacea</taxon>
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            <taxon>Acanthaster</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103435.1">
        <property type="nucleotide sequence ID" value="XM_022247743.1"/>
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            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="232"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022103435.1"/>
        </source>
    </evidence>
    <sequence length="512" mass="57190" checksum="CE49FAEFF0C81573" modified="2022-01-19" version="1">MANSSDPSKIHHSHKDQTAGVKKLGKGQLARNLHEKFTAQNEEREWVDALLDCSPQDETLDAIVNCYSWDEVSTGWRPAVPNPTYVSRVAEKKDSEKEKEKDSAKNRNTQKLIAFQSDLSWKQCIEPGTYRYVYRSAYAGVPRKKTFNKGPVKRPMDANLKEHIRKVKEHLEKVLVQQASPRSQQRPLGAVHNHGDYVTSLIREAKPNRTQPLPDVTYSPKPNHPNEDQTQTKVPNVGITYTVKRGSPIQKSQKSSPLPHPPPAHTENKMPHDLVAALGSKLNDLIQQDSFKTRLKTTRHSKPKAQEKLRSSYEKFTVPVQVESPNLKPLVKVTAGQRQIRDDNEIIGAVAKMNKQATSEADENRPTHHLSQTLNRENLRIPEQEVKEASQDHSFVKLDPTNKNFFTSGIAGKAVSPMEVQVQMQSLAGISTMLGKNPVEVKKRGTLYPQKQGSSVPSGRGDAGFALSNHLGNPLHRGVVDRGVAGAIASELLPGINGHKIRFPVQQMYRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZH15</accession>
    <name>A0A8B7ZH15_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110986534</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
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            <taxon>Asterozoa</taxon>
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            <taxon>Valvatacea</taxon>
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            <taxon>Acanthasteridae</taxon>
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    </organism>
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                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104165.1">
        <property type="nucleotide sequence ID" value="XM_022248473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZH15"/>
    <dbReference type="GeneID" id="110986534"/>
    <dbReference type="KEGG" id="aplc:110986534"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="1">
        <location>
            <begin position="29"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022104165.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24639" checksum="7732595F1D1DD6D2" modified="2022-01-19" version="1">MASKQGEVLNDIFLLGFTKTIQPSDGLLLGTELGFQDSDLKRFEKDYQGDSHRQIYQMLIAWRKRTAGDGLSKVRQLGEALANDRVGLAELRDKLFLEYGISDSKPDKKDAEGSSPDTSGEPALDELYMDALSRKIKPKNRYPLGLQLRFKGAELDTYSDDYRANVQLQIYHMLVDWLNNEKGDVRSKVKKLADCLGNKSVGRSDLSQELLKDFNIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHL0</accession>
    <name>A0A8B7ZHL0_ACAPL</name>
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        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 12-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110987003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Valvatacea</taxon>
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            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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    <dbReference type="GeneID" id="110987003"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="MFS"/>
    </dbReference>
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        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
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            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
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            <end position="319"/>
        </location>
    </feature>
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        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="10"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022105069.1"/>
        </source>
    </evidence>
    <sequence length="382" mass="41095" checksum="F73145FEE525A596" modified="2022-01-19" version="1">MEFNSNGCFIALMAFMSHFISGCIAKGIGVLLPTLRDQLVTHTWIIGIVGALMGVASDVAGLSTLPLENLFGYRRVTISCSIVGSFGMILLPSVTNPVHIALALAVLVGPSLGIFTVLGKALVGRHFSKQYALACGVAYAGQALSLLAVAPMTQVFLDTYGWRGAMLLIAGICIHMVPSAIAVKVIKAEYDPISYTKITNTDQEYQERSEGAVTLCIKAFSRIIRKNLDLTILLEFNFWIVATCRFSVSCVFTTWLLYFVPHLQVKGFSPQVAASICSAGAVGSLIGSIIWSPFVDRGLITSTSGMVLSSLALTLSFVLDPWVTDFISCLAVTLAFGVFASSVYTLVDVMTKEILGKERLVSAFGWMRAFFLPRLIAGFVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJN4</accession>
    <name>A0A8B7ZJN4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosome-binding protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110987098</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105232.1">
        <property type="nucleotide sequence ID" value="XM_022249540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987098"/>
    <dbReference type="KEGG" id="aplc:110987098"/>
    <dbReference type="CTD" id="6238"/>
    <dbReference type="OrthoDB" id="6410656at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040248">
        <property type="entry name" value="RRBP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18939">
        <property type="entry name" value="RIBOSOME BINDING PROTEIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18939:SF4">
        <property type="entry name" value="RIBOSOME-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
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            <begin position="52"/>
            <end position="286"/>
        </location>
    </feature>
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        <location>
            <begin position="897"/>
            <end position="926"/>
        </location>
    </feature>
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        <location>
            <begin position="1046"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1224"/>
        </location>
    </feature>
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        <location>
            <begin position="1263"/>
            <end position="1324"/>
        </location>
    </feature>
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        <location>
            <begin position="339"/>
            <end position="568"/>
        </location>
    </feature>
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        <location>
            <begin position="664"/>
            <end position="752"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
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        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
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        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1110"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1208"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1284"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1315"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022105232.1"/>
        </source>
    </evidence>
    <sequence length="1324" mass="148207" checksum="33CA9560875E3D07" modified="2022-01-19" version="1">MIAVDLYEPQVLALVVFASFIGLSALVYIISIFTMKEKTYEEAIAEQRARLDKEQQLQRDQRQKRRQAFPRKKKEKANDIDQSTPPPSPPSPPSPPVEEKIKPAVEQQQAAAPPPAPQPKTKSPKQAKQTKPQLEQQQQQQQQPKQKQQQQPKVKEATKEVSSREAPSKKALKETQVKEAPIEKAATASTKAAPPPAKTETSPKPNQKSSQKSSQKPKPVEEKLQKKEAPIVAQKATDSQAAPPPPKKDGSGAQSSPSKTKIKGAKSGATVEEKATAGPSGDSAVDTGALKAKNLSAMLKTATLSNKEVQQLVEVLLNKNGGSAAASENWVKANQRDPVQAMKKQLQEKEQALHNEMLLAQSSSQKVKELRAELTQEKSQRIQVDSRFKEAVRNHSRECDALRARLQQNHDVHTRETQNLQTRIKQLEARNDNTGVEALKQLRDENAQLKGEAGRNAQHFQNEIQKLKNQITANEGRARQGEDQRRNLESKLAQYEQQIKVYEAEQAGQRENETALSKRLSEVSEELRKAESRLQNSAREGDKTMERLQSLMKENETVKKQLQEVYRLDSEKSTQMSAMEGRLRDSEKQRINLEGIVNDSKAKLSDSERVCMQKDKEILSLRDTNTSLESQLQAKIQELTQAVEAMKPNGDMGKEEPKEDVILKKEHENIINEKEKALATLQGEISSRENEMETLKQQLEQQKQRNNKLQEKNWKAMEALTAAEKTSEEKVAKALEKEKSLQEVALWSLEEELDACLYKEKEASKSMLMRMFPDINIDATLEYKDWLSQFEKNALNDLAVQKASSGLEVAELSSTLSSVEEEKKQLVSQCQHYKSVLSDTEGILNKLQSSVESEEKKWQDKMSIKDTALAQATKEIASLQEQTKQLDQLKQISADNERLSSELETARTSLSQMEKERSASATEYESTCRELKDVQNQLRQLMEELNTANQRAENSVDVAEMQKVTATLIAEQEKSQKLSSDLEEANRSLEQLRKASSSSKDILQQELQTLRSSSQQLQTELTSTKQDLETASQKLAQSTNQLLSSQQDLVQSRSEAQELKRNLSRAEETAEAAAKERQAAEHSLAALQRDLEASSKEKQETEQNLAALQRDLEVSSKEKQETEQNLAALQRDLEAASKDKQQTEQSLANLKESLDAISKEKEDTENSLSALRENLDAISKEKEETNQSLAALREELEASQKAQQETLESTKKLQESEESTQKLQEEINTLKESLQKEKVLTRDLGTAAAKLQVMLKKTQSALAAEKETVSELKTKADVTGEQAEISSTLTDSQVELQLLDAADDEEGANAKPTKPTDSSDGSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZL78</accession>
    <name>A0A8B7ZL78_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110986488</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104076.1">
        <property type="nucleotide sequence ID" value="XM_022248384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZL78"/>
    <dbReference type="GeneID" id="110986488"/>
    <dbReference type="KEGG" id="aplc:110986488"/>
    <dbReference type="OMA" id="IWLLQMQ"/>
    <dbReference type="OrthoDB" id="8581967at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031084">
        <property type="term" value="C:BLOC-2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017218">
        <property type="entry name" value="BLOC-2_complex_Hps6_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046822">
        <property type="entry name" value="HPS6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14696:SF2">
        <property type="entry name" value="BLOC-2 COMPLEX MEMBER HPS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14696">
        <property type="entry name" value="HERMANSKY-PUDLAK SYNDROME 6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20468">
        <property type="entry name" value="HPS6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BLOC-2 complex member HPS6 C-terminal" evidence="1">
        <location>
            <begin position="336"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022104076.1"/>
        </source>
    </evidence>
    <sequence length="680" mass="75619" checksum="4950A0F29E2D5B41" modified="2022-01-19" version="1">MELCSVTIDESRGRVIWVETQSRGNQDGCHYSVCTRTIMFETTDVKYCVGPVLTLLQNCPKCDLYCSPFAVTIWPSEPCPKGLYFTWHSDSHLLRNQLDTHVLGQGRCLSEDRAGTVVDFKSAASKLRHIWAQKASQPELQVIAKTSHVSTGVLFLICSNGCVHTLNGAEESLNALKLPASINVADSTDWFAYRFVLGAVFKDNMFRVVSNTTGVLLQELDLSTVFSGMNFRFWTIMGMIPRTGIWSSKGIWVLQMDNIESVVSAMGPTEAAATLHSFNQDRLAGRTALQGAYEAYSGQRIGEGAGKGVAGPQHGFQNPGLMVSVLQGAEAGHKPQASQALQSLYERREECMEPDTRLNATTQPLLQQYWALHQEKLGIWDKKSNEAQRPFTVQEVVCRLVDSSSPLSVNLKKSEMNFLCLNAPVATLVTLLDALNLGTLDENGHINFQTLPLDEEELDPSLPPVSFGVQAPESESGLPLFEIICTLMFKECPTQLVEFVHLCQQARDKVMDASAFSRKRSAVQLYDVALGSLPGPDHSRNQEGAVLATAKLLQLSLTSHGALNALKLLLKYKLWSEAIGLVQENADNTQRHSELYHVLLMAILQNREIVPEYYERLWACLPQKISSLEFLKLLTTHHQPSNPRIHLCQQVLCRPQDDLQIGMVRDQLIKLLGRKKVKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLI8</accession>
    <name>A0A8B7ZLI8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Collagen alpha-1(V) chain-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105760.1">
        <property type="nucleotide sequence ID" value="XM_022250068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLI8"/>
    <dbReference type="GeneID" id="110987379"/>
    <dbReference type="KEGG" id="aplc:110987379"/>
    <dbReference type="OrthoDB" id="10069453at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000007">
        <property type="entry name" value="Collagen type V alpha 3 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000885">
        <property type="entry name" value="Fib_collagen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01410">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00038">
        <property type="entry name" value="COLFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51461">
        <property type="entry name" value="NC1_FIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0176">Collagen</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Fibrillar collagen NC1" evidence="5">
        <location>
            <begin position="198"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105760.1"/>
        </source>
    </evidence>
    <sequence length="427" mass="45987" checksum="51B7F24A3E39D8F2" modified="2022-01-19" version="1">MGLTGEVGDPGEKGDKGDVGEPGPRGPKGEQGVEGPQGPMGPEGPPGPRGVPGPPGPQGPRGDTGIKGDIGPAGPPGPPGPEASAAYLQALLDQGILNIRPDLYPNFSPDFPGGTYAPFTAAPGGGGGGPGEASSSGSSYEGSVKRRRRAAGDDPFAGMDPDTGPYKEFEDNQIPESAEDYFYSDYGELPEAYMEALVQLFTSLRALKEEMEQMKNPIGSIKNPARTCKDLYLSHKDFPDGHYWVDPNQGCTKDALEVFCNMTAEGETCIYPDQQGDDPEDYLQEDVLRGYRKSKPGSWFSETKSSPLTYSSISTVQLTFLRLLSTHATQNFTYLCSRSVGWYDKEEGHFDKAIKLQGANEDEFGYGTLLEPTVLLDECKNKPGKGETVLFVNTTKLQQLPIIDFAAYDFGQRSQRFGYKAGPVCFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZME8</accession>
    <name>A0A8B7ZME8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987935</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106793.1">
        <property type="nucleotide sequence ID" value="XM_022251101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZME8"/>
    <dbReference type="SMR" id="A0A8B7ZME8"/>
    <dbReference type="GeneID" id="110987935"/>
    <dbReference type="KEGG" id="aplc:110987935"/>
    <dbReference type="OMA" id="GICIANW"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF14">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01102">
        <property type="entry name" value="5HT6RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="40"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="464"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106793.1"/>
        </source>
    </evidence>
    <sequence length="510" mass="55556" checksum="C479E7B977E6B513" modified="2022-01-19" version="1">MNGTSAPREDGMKGTLSPPLGYFIFQALFLSIIMIVTILGNVAVCYVVYRTRSITTVTGMCITSLALADLFRGILVLPFVVIASIFGGRWTMGDALCSLSGIGYTLFGTASVMTLAAVSIDRYVAILKPLKYTSIITSTRAALFICLIWLVSILMALLPILGWSRYSFNPWNGICIANWMEYKPYACFYLSVSFVLPFSVLTFCYYKIFKVARHQSRRVMSLEVTSVDGRGSTGLGVNLRQRPRKANNRPRLVMRKEKKAAMTLFTVMGVFILCVTPYNVVHLAYAFAGTFNLLVALGVTSMLSFVNSAANPLIYGILNRKFRHVFLEVLKCRYCPRCCCGSSGGLDGFQPDDIPSDLPTASVGHRLKPVPRDSGYITSYTQTTTSTRGCRPDVFAVSVASTSNTLASLGGNMKSIGRIAQGQLPMIEDISSDDEEFASPGIIKNGRMVHPKSGLRARFLDVAEAPQSSADNSSDPLDTTVPGTSTSKDSGQKSPVDDNDFRLILSPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMF3</accession>
    <name>A0A8B7ZMF3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/arginine repetitive matrix protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104526.1">
        <property type="nucleotide sequence ID" value="XM_022248834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMF3"/>
    <dbReference type="GeneID" id="110986711"/>
    <dbReference type="KEGG" id="aplc:110986711"/>
    <dbReference type="OrthoDB" id="6288722at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="678"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022104526.1"/>
        </source>
    </evidence>
    <sequence length="781" mass="89472" checksum="41212D7E4272F2B7" modified="2022-01-19" version="1">MLYTLYIHCTLYMHVCMYLHTCTCKWTVHDGSCCGHAIISQLKRSYSSSTSSRSRSRSRSPLRGNPKYRSHDKKTSRGRSHSRTPPRKDRVFGGGYKGSSSKQRGRRSRSYSPGKRRYGKAKSRSRSPSYRKERYRSPKRSPQRGGREPGHQQSEGGYQEGGGQLHPDSQARDTEGPQLPPGHNVFREEYGRGVQGQDQLPLTSRDVVYERGNSQSEGSQSKFTPTHPSERAYSKERYRENDKTKYEAVSPDDLRFTPKSSRRSESPYRDDRKISKPKPEYYKVQEKYSQPGISGQGYKAALPTESQNVKMAPPPIIRPIFDPYSVKIPRRKDEGLKEIFDRPELKARFTSEHLSSEGAPETRPGAAVEKKEPVVYRQDVHFTGTLPSGVLPPQAQGIIERREPLLSGFEPRRDTYPDPNLQYAPRGGPMGLSSQYPAQQTTFQVQPQDQFGPPKEVPPLQDFNRQSMFVQRAGSPVMGLPQSPVSYQYPPDDLPDIKGPHDLRHDLESRRKQIEQQQQELPPGRMRSLSRSRSRSRSRRISPSPRQRSRSRSRSHSPGQHYKSYHHRRSHSRERSQDHRSRDRRPVRERLGNMSKGSGDNSLSDGEGDSKSFSWTRKRTFYQQHDRRGDRSRSPDSSDSRERGSYRGTANRYRGSMRGTYRGGRGRGRGYVGKNYIPGYNRGMRGRYMPRGGRGSFNAGRRSPTWTHDLFDKEKEEPQDAQDKKDKKKQKIDKGKEKKVVKQKVKQVKKAKKVKKSPSRSETGQKNNDVPQALEPTETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMH7</accession>
    <name>A0A8B7ZMH7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987839</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022106639.1">
        <property type="nucleotide sequence ID" value="XM_022250947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMH7"/>
    <dbReference type="GeneID" id="110987839"/>
    <dbReference type="KEGG" id="aplc:110987839"/>
    <dbReference type="OMA" id="PITPMRD"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF8">
        <property type="entry name" value="NIMA-RELATED KINASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="410"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="289"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="664"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106639.1"/>
        </source>
    </evidence>
    <sequence length="791" mass="89145" checksum="BB5A5B2F794EB78B" modified="2022-01-19" version="1">MPPARGVKKPKDDKSDHRVLANRYLVEKKLGSGNYGTAYLVHDNKANTNKGEEEWKVLKEISCSDLAPDETVDAMHEAKLLSKLHHPNIVRFNDSFLDGEFFCIITEYCEGGDLDDKITACKKSGRQFDQNLIMDWFVQLVLAVQHMHSRRVLHRDLKTRNIFLKNNMIKIGDFGISRVLMGTTDMASTFTGTPYYMSPEVLKHEGYNSKSDVWSIACILYELCSLQHAFEGQSLMGVMYKIVEGKIPEIPKKYDSNIQELLNIMLNRDPDKRPSATEVTKLPFVLRHMEKMKRRIVEMKEQREESREYIERDTQELATLLREKTHLEDLQDVSLREYPQQAPPHPQQHQGPTVQDPYKHLTPKERMRIRKMQLADEKAQVISAHARNNLVENIQRKEVLKGTIGTFNRPAWQGGRGEQHQPVHYGERSQGYSEGSFRGRLPATSPDTYYDDSGGMGDTVSNWEREDMGTVREVSYHSYDDRPVKPTVSPSAYTKEGPYQSYDDRPIKPAVSPNPYSEEGMSTLKAPSAGDNRPITPLKEKINLDDPNISLATPPGLKPLQKKKEPAKGKQTQQSKPAPQKSAKGGKPSPLNTSQGVKPAKSPSSPVKKAPPMNPTKRAAPAKKELESPTKVLSRVAEAIPADADAAETYYSQHEDFESGSESGSDDDVGSDMDDDYDALMECMQSALDTDSGDQGATLKDNTLSPFSPAMRETKIRNLRVECERKIGKESFKNAYAFLKAARFGDRRSAGDTTMDEGEIMKGLKKFVKNPSDCFLIDQLLFLEEQASFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMQ2</accession>
    <name>A0A8B7ZMQ2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8">Double-stranded RNA-binding protein Staufen homolog 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">LOC110987985</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106887.1">
        <property type="nucleotide sequence ID" value="XM_022251195.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106888.1">
        <property type="nucleotide sequence ID" value="XM_022251196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMQ2"/>
    <dbReference type="GeneID" id="110987985"/>
    <dbReference type="KEGG" id="aplc:110987985"/>
    <dbReference type="OMA" id="TKQTPMK"/>
    <dbReference type="OrthoDB" id="10037267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098964">
        <property type="term" value="P:anterograde dendritic transport of messenger ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035418">
        <property type="term" value="P:protein localization to synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19858">
        <property type="entry name" value="DSRM_STAU_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19861">
        <property type="entry name" value="DSRM_STAU_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000007">
        <property type="entry name" value="Double-stranded RNA-binding protein Staufen homolog 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051740">
        <property type="entry name" value="DRBM-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032478">
        <property type="entry name" value="Staufen_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46054:SF3">
        <property type="entry name" value="MATERNAL EFFECT PROTEIN STAUFEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16482">
        <property type="entry name" value="Staufen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="67"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="264"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="339"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="5">
        <location>
            <begin position="446"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="520"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022106887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022106888.1"/>
        </source>
    </evidence>
    <sequence length="768" mass="81690" checksum="3CCB7870847730D6" modified="2022-01-19" version="1">MSHASSPHPVASGPMPVHTAAAGTGTTLPVPNMASQTVTAGLSIQGPTGATGAGPTELNMANTKEKTPMCHLNELARFNRLQPQYELVEETGPAHEKTFTVRLVLGTQNFEAKGTSIKKAQHQAAEQALLNCNLPAPKPKLARIQKSTQPNPNALTATVELNSKAMKAGVAIHYTPIGPDPMPFHNFYRGGRGGHGFRPPRPQGPHGGPGPGGLPMPGGMRPQGPGMGGEPRGPGGPGDFRGPGGPGLRQPYYPRFPRSAGPLPTFYVKVQVGNREFIGEGRTRKDARQNAALKALKSIEADPLPECKDEAVSTSDPPINSEFSSCFAVKDKDEDGLKSDISIVYEKAHQHNLSVNFTVTEEKGPPHLKSFKVECKVGEYMTEGSGNSKKNAKRKAAELMIKNLQMLPTMPKVERPRPYFQIKKKKSKSLIKTRATNPEYEASGLNPISRLVQILQAINKKEPVFSVVEDQTVTEHTGRPGPRNRRREFTIQVLADGKTCFGKGPKKKAAKRAAAEEMLREMGYSSTPPASASTPAKSALKTSNEGDDNSGGDRKVTFKEDPDKKGGEKKKLESPIPGHKLAPGLLPMMPGVNTAAGFPGPTAPTVKQEPAAPAPGLNRAPGAPITGTPIGKKASPTMSSVTSDIARELLNQGSSPTANGIMKGRPGSFVEKKLVRPRQQLEFLGLAQGFGVQFTDFPEANKNELLSVVAVSIDPKLVCHGAGPTLEASHDAAAIAALRSLAGMDQEEDLAKKTPNPSTKLPQTAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMR5</accession>
    <name>A0A8B7ZMR5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clarin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110987888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the clarin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106724.1">
        <property type="nucleotide sequence ID" value="XM_022251032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMR5"/>
    <dbReference type="GeneID" id="110987888"/>
    <dbReference type="KEGG" id="aplc:110987888"/>
    <dbReference type="OMA" id="HLGYSFY"/>
    <dbReference type="OrthoDB" id="10012538at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026748">
        <property type="entry name" value="Clarin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548">
        <property type="entry name" value="CLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548:SF1">
        <property type="entry name" value="LD47387P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25807">
        <property type="entry name" value="Clarin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034510133" evidence="7">
        <location>
            <begin position="27"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022106724.1"/>
        </source>
    </evidence>
    <sequence length="247" mass="27153" checksum="F2A3A086A47A36A8" modified="2022-01-19" version="1">MASKRSKVPLALVFIFSLAAVGALLAAAATPHWVAGVAVRQNLTDNERPQVPDENGQIPPFTGYIQFGLFNGEKIFNFGFTQRAPVYFSIFEEHAEVYSIGFPIAAFVSVLIAAIFGLVSTIFGLVNTITVPIETIHGPVGLYVWNGIGAVCSLVAWVIYLALLLTKLTTNILNKSDIDPPNNFRTDSVSFAYSYWLVVVACALFILNLICVFLAKLLSDPDFLQQRRGEKEFSKGENNVGMDEMMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQF8</accession>
    <name>A0A8B7ZQF8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110988447 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110988447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107634.1">
        <property type="nucleotide sequence ID" value="XM_022251942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQF8"/>
    <dbReference type="GeneID" id="110988447"/>
    <dbReference type="KEGG" id="aplc:110988447"/>
    <dbReference type="OrthoDB" id="10029037at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052001">
        <property type="entry name" value="MHC-II_Gamma/Thyroglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14093:SF21">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14093">
        <property type="entry name" value="HLA CLASS II GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase FkbM" evidence="6">
        <location>
            <begin position="168"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022107634.1"/>
        </source>
    </evidence>
    <sequence length="605" mass="67474" checksum="AB166313D7E46BC1" modified="2022-01-19" version="1">MLNKLLPNRPISCGTRELPCMMATTQSLHYCNVAPARLPINTFCWHAYHLCFSNICGVVTLHVNWIKDLAEGVELSVGKGTMRWAHPSTFVVLAVGFCMGLVPSTLLWGSVNFLYGRGTRSGTVSQHSLQHAVEQALPLRSSQSSGRAKDDPESGQSSSRLPKKVLLDCGANVASTVLLFRETYPGGRDFTIHSFEIDDRLSPYFSPYDKHHLHCPVGVAGKDGNMTAFSETVWGPHKGLNHGRDMQWGGGSLFVSEKELKDEAKGGVRKLSYRQTIPVVDLSKWITNTFSVNDYIILKLDVEGAEFDILRKMIDDNAFAYIDKYYGEYHDGQPTGWSKEGKNKIRSDIRKAGFTMIKWVGETRTYDDIEKVNPVKVPPDTPGRPGEIYSNCQSGSVAVTVAVGMNFKRAHRVVATLLAHKPLVPTTLFVYGDFVQVFPETVKSWAKHFNIGIREDGHNPPGHLELMPGHWVRMGLISSILRLEEIGITASYYLPTVEKDIGVTIKTMAEARGLRIIRPAVEFPAPIGSAAELTWDNYYKYRDVERVPKALRRIHDALVKNSGGVLTLDTDLPDTYMNSVFMMDYLVETSGFKLVDLNECIVNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTI1</accession>
    <name>A0A8B7ZTI1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-terminal EF-hand calcium-binding protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110988674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108115.1">
        <property type="nucleotide sequence ID" value="XM_022252423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTI1"/>
    <dbReference type="GeneID" id="110988674"/>
    <dbReference type="KEGG" id="aplc:110988674"/>
    <dbReference type="OMA" id="EDSQWMI"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042984">
        <property type="term" value="P:regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039862">
        <property type="entry name" value="NECAB1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12178">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12178:SF10">
        <property type="entry name" value="N-TERMINAL EF-HAND CALCIUM-BINDING PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="ABM" evidence="4">
        <location>
            <begin position="235"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022108115.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="38628" checksum="97F11050D3AC8A32" modified="2022-01-19" version="1">MASIEKEKGMSIFLDVFRRADKNDDNCLSWDEFRSFFTDGVLTSSELDTLFHEIDTHNTTNIDTGELCTYFSKHLGPYREIFAALEDINSSVSTALQTTATEYPEKNFQDQFCVRFLLKEVQTQLAALLGTIGAASDHLEEEAVKNSDDDEGNTRSGQTQVHFDEPPVSTKAGWLARRAKRQLSTQTSIPFDSASMNAFFTQVNRLQEMLDKLENRVTLDPVDEEIVKDDSNMLMLVARKLCVLESEDKPFRSTLRTYVEAAAKNDGCLNLSVRSYSGTSNFVLYEMWDSEESWKNHFGSNVSKAFRHSNVDHLEKPEEMSNLAIPASWISDSSPTCVISGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV85</accession>
    <name>A0A8B7ZV85_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110988971</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108690.1">
        <property type="nucleotide sequence ID" value="XM_022252998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV85"/>
    <dbReference type="GeneID" id="110988971"/>
    <dbReference type="KEGG" id="aplc:110988971"/>
    <dbReference type="OMA" id="VVTVFWD"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009069">
        <property type="term" value="P:serine family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044272">
        <property type="term" value="P:sulfur compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="16">
        <location>
            <begin position="39"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022108690.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="39690" checksum="A19BA3A14080C045" modified="2022-01-19" version="1">MAAPWKKFVVNACRELPVLQSFRRTVWKDSIRGGFVGMVGKTPLIRLEKLSEETGCDITVKVESSNGGGSVKDRAAVFLIKDALERGQLKPGGTVVEGTAGNTGIGLAHICNAMGFKCVIFMPDTQSQEKIDLLRVLGATVYPVPAVPFTDPDNYNHQAKRYAESLENAIWTNQFDNTANLRAHYETTGPEIWEQTAGKIDAVVFATGTGGTLAGVGKYLKEKNPNVRVFLADPQGSVLYNFIKHNKIERTEGSSITEGIGQGRVTDNFKEAPVDDAFAIYDKDAVYMTFRLLHEEGFFVGASSGINVAGAVEAAKKMGPGHIIATCLCDTGQRYYGRLFNREWLKSKGLLDCLPPEYQTTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZW64</accession>
    <name>A0A8B7ZW64_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Charged multivesicular body protein 2b-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022109005.1">
        <property type="nucleotide sequence ID" value="XM_022253313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZW64"/>
    <dbReference type="GeneID" id="110989153"/>
    <dbReference type="KEGG" id="aplc:110989153"/>
    <dbReference type="CTD" id="25978"/>
    <dbReference type="OMA" id="NREACKV"/>
    <dbReference type="OrthoDB" id="5594417at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109005.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18044" checksum="FE6AC684B65D3295" modified="2022-01-19" version="1">MFRKKANEKEVMRKVDRDLKGTQRGLERDRAKLEREEQKLTLEIKKAAKQGNKQAATVLAKQLVNLRKQKTRMYGASARVSSINAQAKVLDDTLEAMFEESGDEEEQDAIVNQVLDEIGIEVAGKLSDAPTASYTLPAGKEKTRDTADQEIEAQLARLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXW9</accession>
    <name>A0A8B7ZXW9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C-type mannose receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109942.1">
        <property type="nucleotide sequence ID" value="XM_022254250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXW9"/>
    <dbReference type="GeneID" id="110989687"/>
    <dbReference type="KEGG" id="aplc:110989687"/>
    <dbReference type="OMA" id="KPWANAR"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="107"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="262"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="2">
        <location>
            <begin position="387"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022109942.1"/>
        </source>
    </evidence>
    <sequence length="629" mass="70754" checksum="1E549AD2436247CD" modified="2022-01-19" version="1">MLVQAPASNVWIGLNDRTVEGVYRWADGTPLTGFTNWGPNQPDNGNKAFQEDCMYLRANENFPGEWYDGYCDYPRAYICEKPQDPSIPVDPPSFPCYVELDPTYIIYVRACYKLESSTTRSYQDAVSFCENDHEGVRITWIEDAFQEAFLQAMLFNAGINSAWIGLETLRGINNLKWQGREALTYTNWAKNQPQDTTRCGILTTEGWKDEDCNAKHPVLCRQNLGRRPSVPPTFPGSVCPAGMVEIDDQDCAVGINSTFATSWEEAQEICKAYDSSSSLPSVHTLNEDNNLAGLFYTDPDLEVWIGLSPSDRDQYQWVDGSLLDYVNFGSNTPGDGCGVMVISPGSGQINVEWKTADCNENRGFICRAPKVYTPPSKGGCLPGWYQLGIRCYRSVGLLDADRRDFSDSDEYCREEGGGRGRLFQVTSQLEQSLLSLLLQEFVNKTNLWIGLSDANEEGQFVWTDGTPMTFSQWAPFQPDGFTDIPNEPFRDCVEVRTDPQHLGEWDDINCLERRGYICQTFLDLDSNSTNVVIPEMCANRPGYSKYKDSCYKLVDQMLSFADAQNFCSQEGAWLATSRDGFYNAALSLLVNWYSPTPEYVWIGLDQASRRLTAIIIAKLIALTTAQWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY88</accession>
    <name>A0A8B7ZY88_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-Q</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cyclin-related protein FAM58A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC110989756</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin-like FAM58 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110056.1">
        <property type="nucleotide sequence ID" value="XM_022254364.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110057.1">
        <property type="nucleotide sequence ID" value="XM_022254365.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110058.1">
        <property type="nucleotide sequence ID" value="XM_022254366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY88"/>
    <dbReference type="GeneID" id="110989756"/>
    <dbReference type="KEGG" id="aplc:110989756"/>
    <dbReference type="OMA" id="MYDMMKY"/>
    <dbReference type="OrthoDB" id="79090at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20534">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20535">
        <property type="entry name" value="CYCLIN_CCNM_CCNQ_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000122">
        <property type="entry name" value="Cyclin-related protein FAM58A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000042">
        <property type="entry name" value="FAM58A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048055">
        <property type="entry name" value="Cyclin-Q_first_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048053">
        <property type="entry name" value="Cyclin-Q_second_cyclin_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022110056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022110057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110058.1"/>
        </source>
    </evidence>
    <sequence length="252" mass="29223" checksum="C6B4F19C6423652A" modified="2022-01-19" version="1">MPSSLLMATVTMATTSSSEVSPSDPAIAKAHFRVAQYMMEAGIKLHLQSVTVASACTMYYRFFSVCDVRNYDAYLVGAAAIYLATKVEEQHVKLRDIINVCYRILHREEAPLEVGKKYWDLRESVINCELLLIRMLKFNPKVTLPHKYMVHYLKSLQDWMDQNMWSKTPICRMAWAMLGDCYHGSICIRVKPQHLAVAVIYFAMQCYGVNMPHQEDQAKKKWWQVFSEELNEEKVQEIVAELIDMYEMETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY90</accession>
    <name>A0A8B7ZY90_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="10">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110990034</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022110503.1">
        <property type="nucleotide sequence ID" value="XM_022254811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZY90"/>
    <dbReference type="GeneID" id="110990034"/>
    <dbReference type="KEGG" id="aplc:110990034"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05584">
        <property type="entry name" value="STKc_p70S6K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000092">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016238">
        <property type="entry name" value="Ribosomal_S6_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000605">
        <property type="entry name" value="Ribsml_S6_kin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="72"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="17">
        <location>
            <begin position="334"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="78"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000605-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022110503.1"/>
        </source>
    </evidence>
    <sequence length="469" mass="52693" checksum="CDD8C12A9B60197A" modified="2022-01-19" version="1">MMAAVFDFELNEPGAQQLTNHQENVSDDDAVEEQYLTASSGSVPDEDEDIEQLALSEHTVNPHNERVGPEHFQLLKVLGKGGYGKVFQVRKIAGTDPGKIFAMKVLKKAVIVRNQKDTAHTKAERNILEAVRHPFIVKLHYAFQTGGKLYLILEYLCGGELFMHLEREGIFMEDTACFYLSEITCALEHLHKQGIVYRDLKPENIMLNKQGHVVLTDFGLCKESLEEGSMTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMYDMLTGGPPFTAENRKKTIDKILKGKLNLPPYLTHDARDLLRRLLKRTVVSRLGSGPEDAKKIKEHSFFRHVNWNDVLASKVEPPFKPLLANDEDVSQFDTKFTKEPPVDSPDDSMLSESMDQIFLGFTYIAPSVLESMQRPHVVKARSPRKITGQSPHTPISSPMKTPCTQFAFDEDLVNTKSPTSSTVEAMDTSEPITRAGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZ95</accession>
    <name>A0A8B7ZZ95_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 2C15-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110989088</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108906.1">
        <property type="nucleotide sequence ID" value="XM_022253214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZ95"/>
    <dbReference type="GeneID" id="110989088"/>
    <dbReference type="KEGG" id="aplc:110989088"/>
    <dbReference type="OMA" id="VPHSPIE"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF397">
        <property type="entry name" value="CYTOCHROME P450 2U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022108906.1"/>
        </source>
    </evidence>
    <sequence length="561" mass="64000" checksum="59E82AD828E02856" modified="2022-01-19" version="1">MGGGIQRMLPVTFMLGFLKKLSRNSHHRRLLQITVLLSLIWAIIKRLKKQRELQANPARGLPLPPGPWGWPIIGIMPTLAHGYPQKIITEMSKTYGSVMSFKLGSHLAVVLNDFDTIKEAFAKSGDKFSDRPKVTMFESIHPAGAGVVLSYYDNHWKENRRFTLRTIKKMGIGKAAMMESKISEEARFVARSFDEQGDRPFHPTYFTNLAVANMINSLVFGKRNDYQDPLFLQAISKMMELFKVFGVGAANFLPNVMKYVPGSQFRQAMKIVKFFEEKWYGPQILQHIETFNANNIRDFIDHYLLEKFFKEGSIHYQDFPAVLGAVGDMFGAGLETTSTALDWVFLCMVKYPEAQAKAQRELDKVVGRYRMPQWGDRHNLHYVMAFLDEALRWSAGGPFGVPHSPIEDTDFRGYFIPKSAVVIANLHAVMYNPEVFPDPETFKPERFLNEDGKFVKHEHVAQFSIGRRACLGEHLARMEIYIIATHILHQFTLTAPGGNTDSIRTDGIIGLTKNPHPYKICSIRRTDTYDITEIPMDLLSDDNNNNKEDRNNNNECKHGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZH8</accession>
    <name>A0A8B7ZZH8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108981.1">
        <property type="nucleotide sequence ID" value="XM_022253289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZH8"/>
    <dbReference type="GeneID" id="110989140"/>
    <dbReference type="KEGG" id="aplc:110989140"/>
    <dbReference type="OMA" id="ILNYVNY"/>
    <dbReference type="OrthoDB" id="2434756at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009622">
        <property type="entry name" value="NDUFAF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338:SF4">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13338">
        <property type="entry name" value="UPF0240 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06784">
        <property type="entry name" value="UPF0240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108981.1"/>
        </source>
    </evidence>
    <sequence length="145" mass="16436" checksum="2283360281C52191" modified="2022-01-19" version="1">MSRTGNPDVLEKQQKKDERLLGFLQNVRVDSTDPEQPKPLEGAESKASGSSPQRRLPTSRKPLPKVTTMFEVPDEVPEGRLTVPMALEILAKHKRNPKEWPAERLAADYKLDLTDTTHILEYFRSFKVIPVEGSTLPPPRRLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZH9</accession>
    <name>A0A8B7ZZH9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">AP-2 complex subunit mu</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110989811</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110140.1">
        <property type="nucleotide sequence ID" value="XM_022254448.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110141.1">
        <property type="nucleotide sequence ID" value="XM_022254449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZH9"/>
    <dbReference type="GeneID" id="110989811"/>
    <dbReference type="KEGG" id="aplc:110989811"/>
    <dbReference type="CTD" id="1173"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="11">
        <location>
            <begin position="168"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022110140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022110141.1"/>
        </source>
    </evidence>
    <sequence length="430" mass="49081" checksum="10F8762D78B503D8" modified="2022-01-19" version="1">MIGGLFIYNHKGEVLISRVFRDDIGRHAVDAFRVNVIHARQQVRSPVTNLARTSFFHIKRGNIWLAAVTRQNVNASMVFEFLMKLCEVMSSYFGKINEDNVKNNFVLIYELLDEILDYGYPQNTDTGILKTFITQTGIKSQTREEQAQITNQVTGQIGWRREGIKYRRNELFLDVLENVNLLMSPQGQVLSAHVAGKVIMKSYLSGMPECKFGMNDKLTLDKQGKGDSDSKSKSSIAIDDCTFHQCVKLSKFESERSISFIPPDGEFELMKYRTTKDISLPFRCIPLVREVGRTKMEVKVVLKSNFKPSILGQKIEVRIPTPMNTSGVQVLCMKGKAKYKSSENAIVWKIKRMSGMKEVQITAEIELLPSGDKKKWARPPISLNFEVPFAASGLKVRYLKVFESKLNYSDHDVIKWVRYISRSGLYETRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0P5</accession>
    <name>A0A8B8A0P5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hyalin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110990576</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111328.1">
        <property type="nucleotide sequence ID" value="XM_022255636.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990576"/>
    <dbReference type="KEGG" id="aplc:110990576"/>
    <dbReference type="OMA" id="ILYLCVP"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034860998" evidence="5">
        <location>
            <begin position="29"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1405"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="26"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="261"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="675"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="845"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="7">
        <location>
            <begin position="1013"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1096"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="1133"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1122"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1142"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022111328.1"/>
        </source>
    </evidence>
    <sequence length="1463" mass="154340" checksum="AD22C406314DB073" modified="2022-01-19" version="1">MLTSRIEIYVACLRSLLILYLCVPDILCQGPSLVCPNIFTPPDANENYATVYWPIPRSMDVDGDPAAVTCNLPRGGKFEGQISIVQCTAVDTSNRERTTTCQLLIAVTPRFNRGCPPDISQENSMVTFAKPIGEQNFAGGDLSPVECSHESGDVFEPGLTLVNCTAIDTSINLEATCSFKVSIGTLPKFANLGSCGDAAIVNTAPDDGQNTATAITGRWTRPTKDGGGDVVCDPDPDTHTFVAGVTTVTCMVADSNVPSLIDTCSFKVRVFPTFPNGCPETIISANGMDVDFTPPNAIDSVSSTIPGTCDKASNDTFESGETTVRCSAMDSVETTQTVTCSFVVAVGTPPDFDSRGSCDSSPVNVPPDEGKMTATGIVGQWTRPTRAGGGQATCSPDPDTTTFVGDRTEVACTIQNDQAPSITTTCTFDVGVFPAFEKDTLLGNPFRSPDPGANYATYAYLDPLAKDSNGASLPVVCSPMSGAQFGGGTHEIQCIATDASANQDSTYTFNLTVAPVFKTLCPNDIIQATNPVSFPVPIGGDDPRGKPFPVTCTKNDRDVFNPGTTVVICTVTDPVTKLVATCSFTVTIVVAPTFDASPACDEDYNTEPAPGENRAIAVTWPERAATQADGNPANVTCEPVPGSDFEAGDTNVTCTAADTRLPPSITPTTDCVFRVRVYPTFVEGCPNNIIQIPDDSGPSTIVNFEIPEAAIDSGGKQAANVTCDPTSGSAFRNDNETVVTCTAIDSVTLGEATCSFTIRFLAAPTFNATPPCDENVNVPPAAGENMAVAVTWPKRAATQEDGNPAMVTCEPSRGSNFPGGNNTVTCMAVDERAPDTLQTTCDFQVRVYPTFVTGCPADIVEAPESGGTTLVEFQIPEGAPDSTGAAANVTCEPPSGSSFANNVATEVTCTAIDSDNATFPSPATCTFKVIVGIAPTFAKGCPADIVVAPDENGQATVTWDEITGNEDSTGQPAEVNCDHKSGNTFNQTETLVTCIATDAGTTLTANCTFRVILDSEPPILDCPNNFNITANPGTNTANVTWDTPVVTDNYTPQPDIRVACIPETATFFPYGVTRVVCYAADSLNNVGTCSFEVEITGANCVETCPGNSVCMLQEDGESVCVCNQGYTGPECTNVDECASSPCHSNAICSDLAPPDFYSCECQEGFYGDGTYSCERYFPPEYPDILLPGGAYDLKKLFLVVLAIADPSTSDCNPDVDTMSFECSTLVRTFKELVLPLYKKVSKGGFLDIKINQTDLRKGSVLIPHTVSYNYSDAAIREMQPAVFYARSVQPDVEAGRVGSLQLDKSCKECTSPKDITSVCVGVDEETIVCPDKSVLTKESDASSGLCIYKCVSICEEDSSYCNGGVCSQKNNEDAECSECPEGTTGPRCTPVGPTEVPPDEPNIPLIVGLSVGIGGILLLIVILNMLYCALRGRCSKKNLQAGEENGIEAKGVDNFQSISMDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A246</accession>
    <name>A0A8B8A246_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">BK channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110991010</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022111759.1">
        <property type="nucleotide sequence ID" value="XM_022256067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A246"/>
    <dbReference type="GeneID" id="110991010"/>
    <dbReference type="KEGG" id="aplc:110991010"/>
    <dbReference type="OMA" id="XHIVVCG"/>
    <dbReference type="OrthoDB" id="10035564at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF33">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="18">
        <location>
            <begin position="339"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="18">
        <location>
            <begin position="753"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022111759.1"/>
        </source>
    </evidence>
    <sequence length="1107" mass="123871" checksum="9714FC8CA9990143" modified="2022-01-19" version="1">MLNHSIKRCYGPECEDVVCTGRYWWLFLASSLVTLAVGTGLVFLVRFITRLPCLNRRRHHVAGPDGSGCCAGICPINLLEKNAEAEIHSIEAAKDWATRLLSAQSRFGRILLITYFCISMASYAIYVIDTGKPIERCLPADRGDLLFFIDNIFNFFFLGVFIFRFISWNDKFWFWFSVNTLVDIFTIPPTFVSLIISRTWLGLRCLRIMILMQLPEILQLLRVLRTSNGIKLTSLLTIVAGAWLTSAGIYHLVENSGDPWINFNNSQSLTYGQCIYITVVTMSTVGYGDLTPKTTCGTIFIIFFILGVLAIFASALPEIVEIVGKGNKYSGVYEPVKGKKHIVVCGHITYDSVSNFLKDFLHIDRDVVNVNIVLLDTTDPDLELQALFRRHFTKMRYFQGSVFNPSDLQRVKLNESDACLILCNKYSPRPDTEDSGQIMRVISIKNFNPEMRVIVQLIQDHSKTHLLNIPSWNQAYGDDVICIAALKLGFIAQTCLAPGFSTMMANLFAMRSSSEIHVKVVKDDPTERVVETQSVVKNASSPAETYLESPEGWMSHYLHGCGNEIYTESLSRAFDGMTAPEMVKECFIKLKLLLIAVQQNNEFDETEIIINPGPYITINQGTVGFFLAPDATEAKRAYYYCRACHSEGVEVEKIWKCECKECESLDNNHAKKYTHKDGHKLLAMTRLGDHHEPAPARSPSAELAELKIQGVNLSESSDHDRPAYDFTGLFHWTPARTVEDALITSAQKRRYLVNHIIVCLFGDESSPLIGLRNFVMPLRASNFKYEDLRTIVFLGNIKYIEREWDKIMNFPKVFIYNGSPLSRADMCNVNVHQSAMCVILSANLGDSVEQGLQDKETILSSLNLKSIMAAGAHSRRSKIIAAYAAESPTRLNGGSIKRSLSTQGTPKITVPMITELVNDVNVQFLDDDDEDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNAHSLTLIRTMITGGTNADLEEILAEGGELPPGVQISRTRLKELLRDRCTVAQLSIGTGVFQQFKEGAAYGSLFLHALESGILCLGIYRNLIIAGKSSSKRYVITNPPQDFDILAGDRIFCLKHFEDLNMNKEIPETALIGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A4F0</accession>
    <name>A0A8B8A4F0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Very long-chain fatty acid transport protein</fullName>
            <ecNumber evidence="14">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 26 27 28 29" type="primary">LOC110990224</name>
    </gene>
    <organism evidence="24 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26 27" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="14"/>
    <dbReference type="RefSeq" id="XP_022110798.1">
        <property type="nucleotide sequence ID" value="XM_022255106.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110799.1">
        <property type="nucleotide sequence ID" value="XM_022255107.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110800.1">
        <property type="nucleotide sequence ID" value="XM_022255108.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110801.1">
        <property type="nucleotide sequence ID" value="XM_022255109.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110802.1">
        <property type="nucleotide sequence ID" value="XM_022255110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A4F0"/>
    <dbReference type="GeneID" id="110990224"/>
    <dbReference type="KEGG" id="aplc:110990224"/>
    <dbReference type="OMA" id="NIQICEC"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF22">
        <property type="entry name" value="VERY LONG-CHAIN ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="22">
        <location>
            <begin position="61"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="23">
        <location>
            <begin position="506"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022110798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022110799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022110800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022110801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022110802.1"/>
        </source>
    </evidence>
    <sequence length="632" mass="70132" checksum="41F7DEC2B92AB2B0" modified="2022-01-19" version="1">MGLLLQLLGGVLGGVSALAVLFKLTYPTFFHDLSQFLLIVRKVVTPTEKLLEKGILQVDVFESHAKRNPEKVLVLYKDEKHTYSDIDHAANKMANYLQKTDAVKVRDIVGIFMHNEPAYISTVIALLKLGTTGAHLNISLRGDALINCIRVGKIKTIICGGDAELVAAIQEILTTLEAEDIKVFMMQEPEGQTLPNGFLPVDLASPLASTEAIPRDVRKGILPSESAFYFYTSGTTGMPKAARMTQKRVMVGGSLLQMFNLSSSDVMYIPLPLFHSAGMVIGVGNVITAGCTMVIRNKFSASHFWEDVRRYNVTVIQYIGEICRYLLAQPKGDSDMERNHSVWLAIGNGLSTDIWTDFQDRFCIAQIGEFFASSEGNRGFMNTDGTVGAVGAYSPLTKLLLNDVEIIECDWETAQPIRGPDGKCIILPKGKTGLMVSKISKAAEFEGYVAGKEADEKKIIRNVRVMGDAYFNSGDLMMIDSKNYVFFKDRLGDTFRWKGENVASSEVAAILTDLPNIKEAIVYGVRIPGYDGRAGMAAIVLQDGTETLEWKEVYAEVANRLPTYARPKFIRVKDQMETTQTHKYRKLDLVKEAFDPESCGTDKLFFMDESQKSYVPLGKDLHCQILNKDVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A653</accession>
    <name>A0A8B8A653_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16" type="primary">LOC110990673</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNF181 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022111450.1">
        <property type="nucleotide sequence ID" value="XM_022255758.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111451.1">
        <property type="nucleotide sequence ID" value="XM_022255759.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111452.1">
        <property type="nucleotide sequence ID" value="XM_022255760.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111453.1">
        <property type="nucleotide sequence ID" value="XM_022255761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A653"/>
    <dbReference type="GeneID" id="110990673"/>
    <dbReference type="KEGG" id="aplc:110990673"/>
    <dbReference type="OMA" id="MHIAKEM"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16465">
        <property type="entry name" value="RING-H2_PJA1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="935"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="366"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="717"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="777"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="606"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022111450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022111451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022111452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022111453.1"/>
        </source>
    </evidence>
    <sequence length="984" mass="106777" checksum="21EE66382CC0936B" modified="2022-01-19" version="1">MSSSSSGPGLPSIDSSHCTRAASDKTRERPSRDLPGVGYTPQGTSTSFQSTPKAKRDLRPRLPSQQVSRGENGRHHLSVHNRPSRSLATGTENADRLRNWNSEGGRPKRERVLSERTNSKRLLHRSSINSSGELIPFQRAPRDGSYESRLPVGKKATLQNPARQNSLFSSTESEHRRAARLQESPESVDELSSSSVAENAERSQSLSLDETKHSSKAKVLKKSSDSRKDGMRAPRQLSTQGVGNGVRKAQSENKHRRHTQSDITSHGVPSLSKKEQSTSDNESEETAQHISNGMSVSGFGSSSAISSNIAENTLEANARPDLQQTGNGPSSQSASSSQNSFREPPIHNVFDGCDLASSHSARAISPSAEFKAAAQPESSAGNEQSSVTSSISSTIANTNNRSALQSESEANLQAPSNNESDVSGGEPLLSSQQPNSVIRRRMNLDGTADTSQIQPSQVSTPSFASNYRPSRRRDEISSHSDQTSSGHLTTAGSSTPEGPELPNERGSSASQQLPSPRVSPHLVHATQPPSSSNMNSTSAVNPSSTSQQARHSRFGRRIRMPSSDLDAAGESTHPTHDASGSPTPAVEEPFEGTNRQRYRFFSLSRGRSQTNHEVQASTLTPNRDLLYGPPSPPLLRRHHRAHFGPDTSTSRQTSEELGASIGIHSSFSSSVGSGDLALQEDSFRTASGSTVAFSPILHSGPVLDSSMPHQRWRMRETATTSGVTAHGRLSSSEITSPRQLRATSSPETQNGGAGVNLSSDFGQDNFTFSVEEGRLSRDARRRYQNDRSDAIPRLLPQRSHQPSRELSRGAEVMEDVFGSSQDRNPPSSDDSPLRDPTLELQIPLLSSPLFSPLGIAPGMLLSLLIRTRREFGQEFMELLLENMMLNVLAHHLFENERGGNEDGINGAPPPATQEVIDNLKEIPALESHIEKEMKCAICHSEYELYETLAELPCEHFFHPTCVAVWLKKSGTCPVCRFLLPSPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-07" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q2L682</accession>
    <name>Q2L682_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">ATP6</name>
        <name evidence="15" type="ORF">KEG27_p07</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="13 15"/>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2006" name="BMC Genomics" volume="7" first="17" last="17">
            <title>Complete mitochondrial genome sequences for Crown-of-thorns starfish Acanthaster planci and Acanthaster brevispinus.</title>
            <authorList>
                <person name="Yasuda N."/>
                <person name="Hamaguchi M."/>
                <person name="Sasaki M."/>
                <person name="Nagai S."/>
                <person name="Saba M."/>
                <person name="Nadaoka K."/>
            </authorList>
            <dbReference type="PubMed" id="16438737"/>
            <dbReference type="DOI" id="10.1186/1471-2164-7-17"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="13 15">Tube foot</tissue>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2006-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="NCBI Genome Project"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="15">Tube foot</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Tube foot</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="AB231475">
        <property type="protein sequence ID" value="BAE79172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_492659.1">
        <property type="nucleotide sequence ID" value="NC_007788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2L682"/>
    <dbReference type="GeneID" id="3907686"/>
    <dbReference type="KEGG" id="aplc:3907686"/>
    <dbReference type="CTD" id="4508"/>
    <dbReference type="OMA" id="FFDQFMS"/>
    <dbReference type="OrthoDB" id="5976622at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Mitochondrion MT"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="BAE79172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="YP_492659.1"/>
        </source>
    </evidence>
    <sequence length="230" mass="25251" checksum="E5B6CF969196F409" modified="2006-03-07" version="1">MNLNLNNIFGQFSPDLVALVPMTLIALVLNLGWLSLTSGTNWLPTRSGALIQAFKRETLKILFQQANPNVAPWIPAFTSVFIFILSVNVLGLLPYAFTSPSHISLTYSIGIPFWMSVNILGFYLAFNSRLSHLVPQGTPSYWIPLMVIIETISLFAQPIALGLRLAANLTAGHLLIYLLSTAIWILANSPLIAGVPLSIFFLLFLLEIGVACIQAYVFTALVNSYLAQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHQ5</accession>
    <name>A0A8B7XHQ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Histone H1, early embryonic-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110973651</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080329.1">
        <property type="nucleotide sequence ID" value="XM_022224637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHQ5"/>
    <dbReference type="GeneID" id="110973651"/>
    <dbReference type="KEGG" id="aplc:110973651"/>
    <dbReference type="OMA" id="YMEERYK"/>
    <dbReference type="OrthoDB" id="10070184at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467:SF20">
        <property type="entry name" value="H15 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11467">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="9">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022080329.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="23063" checksum="5B5214DF3A05B141" modified="2022-01-19" version="1">MAEQTTTAKPAKPKKAAPKKKATHPSAGEMIQTALANLKDQPRSGSSLQAIKKYIHANYTLPANYDNHIKRGIKTLVASGKLVQTKGKGASGSFKLDNRKAKATASLKAKKEKARQKAKAIKEKKKEINKVKREKAAAKKAAKKAAKKAKSPKKKQTEKKKSPKKQVKKDKKPVAKKATKKPAAASKAKTVKKAKPKTTKKTKKPTKKTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XI70</accession>
    <name>A0A8B7XI70_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110973253</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022079630.1">
        <property type="nucleotide sequence ID" value="XM_022223938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XI70"/>
    <dbReference type="GeneID" id="110973253"/>
    <dbReference type="KEGG" id="aplc:110973253"/>
    <dbReference type="CTD" id="60558"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="97"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="171"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="225"/>
            <end position="228"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022079630.1"/>
        </source>
    </evidence>
    <sequence length="698" mass="78254" checksum="29EEE09EF163FFEA" modified="2022-01-19" version="1">MLLLKQYRCQLCRCFKVVRNRCNDSHDSAICTASATPTYPSSVVSSVPVLTATFLRAKINESGRDLQYRRTFCTSVRTAADQKKLGDAVDMSVYPAENIRNFSIIAHVDHGKSTLADRLLELTGTISKKSDNKQVLDRLQVERERGITVKAVTASMFYTHRGKKYLLNLIDTPGHVDFNYEVSRSLKACKGVVLLVDANQGVQAQTVANFYLAFESDLCIIPVLNKIDLKFADPEATANQIKTLFDIEKEDILSISAKLGTGVNEILPAVIDRIPPPQSDLEAPLKALIFDSWYDQYRGAITNIAIIDGKLRKGDRITTAHSGKTYEVQELGIMHPEQVACKELYAGQVGYMIAGMHNLQEARIGDTIYHQNKEVEPLPGFKAAKPMVFAGLYPIDQSEYLALRSAIERLTLNDSSVTLSRDSSPALGQGWRLGFLGLLHMDVFNQRLEQEFNANVIVTVPSVPYKAKMKDTKANRQQYGDNEEITIYNPSLFPERQQVIEYMEPLVLGTVIAPDEHIGKVFSLCLSRRGEQVEYVYIDTKRVLLKYRLPLNEIVVDFFDQLKSVTSGYASFDYEDCGYQAADLVKLSILLNGQEVEELATIVHRDKAREVGKAVCTKLVDTIPRQLYEVAIQAAIGGKIVARENIRALKKNVLAKCYGGDITRKMKLLKRQSEGKKRMKMFGNVEVPKEAFLSILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIY7</accession>
    <name>A0A8B7XIY7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cilia- and flagella-associated protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110973876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CFAP43 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080763.1">
        <property type="nucleotide sequence ID" value="XM_022225071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIY7"/>
    <dbReference type="GeneID" id="110973876"/>
    <dbReference type="KEGG" id="aplc:110973876"/>
    <dbReference type="OMA" id="QTHTWIV"/>
    <dbReference type="OrthoDB" id="535167at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022080763.1"/>
        </source>
    </evidence>
    <sequence length="433" mass="46917" checksum="B287EA07439FEC0E" modified="2022-01-19" version="1">MDNIGTLELTWAQGYGGSDALFINRNTVCHVCSNGIKFIDVTTHRESVHPSPGQGIGVFTVSGSMHLVAFSEMCLNPRIFVFSYPGFTQKAICQGGTKLEYSALAFSHTHPYLATCSAIPDFTLTLWNWETGSLLCSKSMWGLPASNVSFNPTDWHKLCVVGPKQLTVWTIEQADKLYSLVPSKARLPYCDEAETRPKRVDDVPDRPPTEGGLFKIDPDKSAIAGLVGEEAETFDANFDENRRKVTPTSMCWTTTGDVYCGCEGGQLLKYNTETQVVTMMYNPDERKGSVASRAQSAEALSRMAPVPDEEETKSASKSLSIKEGTLNCLALHREGLFAGGEDGILRCLDVAHGVVQVLDSWSSGAAISSLCWSPSYSKLAIGSPKGCIHLYDHSNPGTADTLIDTHNGIFIAVAMLAPGTQHCVVRSYGYGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XK38</accession>
    <name>A0A8B7XK38_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box/LRR-repeat protein 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110974108</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081169.1">
        <property type="nucleotide sequence ID" value="XM_022225477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XK38"/>
    <dbReference type="GeneID" id="110974108"/>
    <dbReference type="KEGG" id="aplc:110974108"/>
    <dbReference type="CTD" id="222235"/>
    <dbReference type="OMA" id="SITMACC"/>
    <dbReference type="OrthoDB" id="61560at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22977">
        <property type="entry name" value="DD_FBXL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22124">
        <property type="entry name" value="F-box_FBXL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000134">
        <property type="entry name" value="F-box and leucine rich repeat protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001681">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF190">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="234"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="798"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="870"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022081169.1"/>
        </source>
    </evidence>
    <sequence length="929" mass="105661" checksum="089958730DABE3CB" modified="2022-01-19" version="1">MASLKGVNPEVRKYLRRHKVPDVYEAILTGLAVLCPEDPMAYIIDKMKELMRMRLESVHGLDALKWDSLIPEEAKPKKRLSANYLDAIFMFDEENLQPWEWRPTPEMYQKAYQSYNNKLVTMTFGAWLLYHERKKRRRLMMARKMVQAAEYYDLRRQRVHLQHWVKWFRFRRERQESAYNIIINVYNMSLSRLVFEAWHNVMLEARRTREYFERLERGEMDGEDETLFPRGEARDDISLLPRKLAIKIFSYLDLADVSRCAQVCRQWKMITGTSSLWSRVNLSSIKNRVTDRFVCKLLQTCRPYLLHLNLRGCSRLTKPSYVAIGETFRVQDLNLSECDGVNDDVMKDIAEGCQILLYLNISHTNITDATLRLLGRCSRNLQYMSLAYCRRFSDKGLQYLANGRGCRKLIYLDLSGCPQITVTGYKNIANGCSNIQSLCVNDCPTLKDDSILAIAAKCHNIRSISFLSSPNITDASFKAIAQHRRLQKIRVEGMSKLSDASFKYIGRYCSDLRHVYVVDCPRVTDASLKSLAQCRNINVLNVADCIRISDNGVRSLVEGPSGPKIREMNLTNCVRVSDVSILKIMQKCYSLVYGTFCFSEHITDGGAEMLGNLPALSSLDVSGCSITDTGLGALGNNPHLRDVTLSECYQITDLGVQKFAQQCKDLERLDLSHCTQLTDGAIKNLAFCCRRLTVLNIAGCKHLTDLSIQYLSGVCHYLISLDISGCVNVSDKSIRYLRKGCKRLRVLLMLYCKHISKASYAKLAAKIETVSWSDDPIPSSFGPGFDYLAALQKAEADKKKKEKEREKEKGKEKAKENEEADLNERSKDEDKTSSLQDKMSRIFESQPKVSEADLKEYEASIKISYSTTDADGKKNAEGEKSVGGEEFEDRVTPDAETPEEGVHDPAQNGTGDRVTDLPTADEQTPPTDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XK72</accession>
    <name>A0A8B7XK72_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Krueppel-like factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110974133</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022081204.1">
        <property type="nucleotide sequence ID" value="XM_022225512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XK72"/>
    <dbReference type="GeneID" id="110974133"/>
    <dbReference type="KEGG" id="aplc:110974133"/>
    <dbReference type="OMA" id="WEGCKWR"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002639">
        <property type="entry name" value="Kruppel-Like Factor (Zinc finger protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022081204.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43081" checksum="88DDA3782FB359EF" modified="2022-01-19" version="1">MVDVYRTRSSLERESWTLQRLNSAGDLEEESDTNSSSSDEVSCMSDSNSSLSPSEDELFLEYLFSQGLADTDMSSTVRDALFNIRVDNKLDFDAVAEGIYPEAEPVYYPPQPTPIFPPDPLMHHSYNMVEPPKTPYNDYFKPPPYGINTDSQNGTYSQPQWQHCQGGINFATSDSQSQCGKPPVIQDVRHSHSAPTALSSFSVTTGLSVGETSVQVSTSPQNEPPSPRSLSSQRMALLPASGVRITHIPVSKPPRAADTSPTESGTVVRKPVRSRGTGKVADELKIHKCTYANCGKMYSKSSHLKAHLRRHTGEKPFVCTWEGCKWRFSRSDELARHKRSHSGVKPYQCTICEKRFSRSDHLSKHIKVHMNGVTRGMKTANNMMCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XK94</accession>
    <name>A0A8B7XK94_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110973684</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080375.1">
        <property type="nucleotide sequence ID" value="XM_022224683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XK94"/>
    <dbReference type="GeneID" id="110973684"/>
    <dbReference type="KEGG" id="aplc:110973684"/>
    <dbReference type="OMA" id="EICQAFR"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034282093" evidence="2">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080375.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11344" checksum="6446B89C6F8115CA" modified="2022-01-19" version="1">MNRFIVLLLLCAIAVQQINGHPDAAVKEGGRVFRGHPHYCGATLQEKYREICQAFRGVSNQEFLDSKDANTFLFGRGIGKRNLNEECCSEGCSDEEIYEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XL65</accession>
    <name>A0A8B7XL65_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110974310</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022081553.1">
        <property type="nucleotide sequence ID" value="XM_022225861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XL65"/>
    <dbReference type="GeneID" id="110974310"/>
    <dbReference type="KEGG" id="aplc:110974310"/>
    <dbReference type="OMA" id="EAYEFPR"/>
    <dbReference type="OrthoDB" id="26722at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000462">
        <property type="entry name" value="Receptor tyrosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034224195" description="receptor protein-tyrosine kinase" evidence="16">
        <location>
            <begin position="24"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="697"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="147"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="255"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="372"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="592"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="782"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="924"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="789"/>
            <end position="796"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 14">
        <location>
            <position position="816"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="928"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="942"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022081553.1"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118971" checksum="F46A15D39BCD7BF1" modified="2022-01-19" version="1">MGHSSVMLTILRVLLWGLLSGMAQELEGSSLVTQDNVVGEECHDVVLTCQLRGSGQNLALRRRFSWSKHTGAGCSGTRTVSINDCHFDEAGDLLQPEKFNYSVAKDNTSCNLTIKAVRQSDAGCYQCDSWGPSGAVSSCVALDVSDPVRTVSLRQTNSVILEGIPATFTCSAGYGDSQVQTTWSLNGTRLQNGTETALIRRTEGNVDCTGRNETLGAADLTLTRHDSGSVLQCSIRGAGLLETDSLTIPNIQVPPTSVTIINGITGEVYNLPGGEVLIKENDNVAFRCLVNDTKPAASLAWFFRGREMLNGLGREGESAVSLRVPDGTYDVSLPVVMTNIMWTDDGGVLVCRATGPSGSSASLGIKIKVDVPPHNATITTGVLVENVPTQVTCSVDGTRTRSSMVWFLDGISVTNTELQETFFSPELMKTTSVTTLTPHRGQSGSILRCKVFHELLDEPLVTEETLDVYFCPAPSLSCPSYVNTSEPYTLMCETASSRPPASLNLYLDEPFQQLDTDGETAHEPAGDGGTTAVLTAKLTSDRSHYGKTVVCRRTPNEICRREASDECRLNVHFPPAETKLWDGGTSNSDSDPANGSVEVIHGREYSFTCAAYGSNPAATFRWRLGDTELRGAAYSKTEQRDSVGLVGGWDSSSRLSLTVQQDQHHDKSLTCQVMYPSQNVFKQLSLKMNIIAVTLSWSSITIIIACSSAVFLVVVACLLLMLYKMCRHGNRPFPIETDMEMLHVNRTIKFKKGGSNSSLSSRGTGQDSFDGSEAYEFPRDKLKLLDVIGSGSFGLVYKATAEGIFEKGVADTVAVKTPNPCGSSADKEEFLRELEMFPILAKHPNVVSLLGYCRKKEPLYLIMEYVPNGNLENYLRQEKLRIDQSYINLNDVTETVGPTQLLNFAIHIVRGMKFLASVQCIHRDLATRNILLDEQLVCKVSDFGLARHIAAQKQYEMKSKGRVPFRWMAPESILCNVYSTKSDVWSFGVLLWELVTLGSHPYPGQSCAEILEDLQRGIRLKKPAHCSDEIYQLMKDCWEHRPEERPDFETIHQRIEAMLANASGYLLMSNFSTEQYVYMAPGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNE6</accession>
    <name>A0A8B7XNE6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110974779</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082339.1">
        <property type="nucleotide sequence ID" value="XM_022226647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNE6"/>
    <dbReference type="GeneID" id="110974779"/>
    <dbReference type="KEGG" id="aplc:110974779"/>
    <dbReference type="CTD" id="23594"/>
    <dbReference type="OMA" id="RKSHYLN"/>
    <dbReference type="OrthoDB" id="5552484at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11583">
        <property type="entry name" value="Orc6_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000054">
        <property type="entry name" value="origin recognition complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054113">
        <property type="entry name" value="ORC6_cyclin-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020529">
        <property type="entry name" value="ORC6_met/pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13394:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21913">
        <property type="entry name" value="ORC6_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="12">
        <location>
            <begin position="7"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="ORC6 second cyclin-like" evidence="13">
        <location>
            <begin position="97"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="214"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022082339.1"/>
        </source>
    </evidence>
    <sequence length="256" mass="28518" checksum="5CBDFF5A6491AB9F" modified="2022-01-19" version="1">MNPSEIKTLALKIGISSKDVIRKAEELLRLCEIRCMSATALGPNSTCQAVMCIELAATSVDQPIDKNAAIRCSGVTRKVYTTLYKTLENILEMKQDIGIRDLAVQFGCLPAVNPALEILARYRKECEGKMSESARDDVNFNSSLFTTGSLYTACRHLKIKVEKSKFLLVAGVKKSTFDRLSSDLTTHATAVIGERKTGKSKRQGHWLEDLEKSFEEECSPPKRQPIAKQHGVSNGNNDYEEWKRKILEGTKTNTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNS1</accession>
    <name>A0A8B7XNS1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6">Uncharacterized protein LOC110974372</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">LOC110974372</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022081649.1">
        <property type="nucleotide sequence ID" value="XM_022225957.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081650.1">
        <property type="nucleotide sequence ID" value="XM_022225958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNS1"/>
    <dbReference type="GeneID" id="110974372"/>
    <dbReference type="KEGG" id="aplc:110974372"/>
    <dbReference type="OMA" id="ECHAICG"/>
    <dbReference type="OrthoDB" id="10380268at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665465" evidence="3">
        <location>
            <begin position="26"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022081649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022081650.1"/>
        </source>
    </evidence>
    <sequence length="344" mass="37748" checksum="452F9BB17A01B2E6" modified="2022-01-19" version="1">MASTRTAMTWIIIVAAVGYFEPCKAEHDVVSKWRRYGGDMAVAESASVMVFCSCDLMVGLCNITMAAQFFLQDEPECHAICGGRVECAYCAEQGCTCSREDLDTYRLCQSGNRARLFQCTNSCARADVEPMCSCEITIVKHNKSTQKPVDDVLPANKASFNHGLFTGLAVGGCILLVLVVIVLALIIIAIRRRTNNRSPIARTNTNSSTAPITSSADGLKGVNNPTYEDASTTLPGTTRPPSSTSYLYPYAPRLTANRNISVSNGNNASTSASPQPSAQAFPLYQEILPRNGDQPPTYEDSEGYTRYRAQAQPDTRRERQQPVYMELVRPSDRTSRPPVDTYMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ51</accession>
    <name>A0A8B7XQ51_ACAPL</name>
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        <submittedName>
            <fullName evidence="6">Monocarboxylate transporter 13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110975108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022082948.1">
        <property type="nucleotide sequence ID" value="XM_022227256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ51"/>
    <dbReference type="GeneID" id="110975108"/>
    <dbReference type="KEGG" id="aplc:110975108"/>
    <dbReference type="OMA" id="YPGKNNA"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF172">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <begin position="141"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <begin position="171"/>
            <end position="192"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="308"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="15"/>
            <end position="471"/>
        </location>
    </feature>
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            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
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            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022082948.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="55724" checksum="6C081F6F62344222" modified="2022-01-19" version="1">MAAGLAMLGRWTGWLVTFATMVQFFLLFGPLYNYSILFVSFREEFETSAALTGWLGSVANGLISFFSPVGGVLLRWLSHRTVCLLGVAVYSAGALATSFVPNIYWAFLSMGVMMSFGAGASMHCGICLLFQWYPGKNNARATCLALLGTSIGLLAFAPTKTQLIENYGWRNMLRILSGVVFTVGMLDGTLLMPASARQQRRPADGGSASAATGMRLLELQPRGEDTEQPQCVDKATDPFCDEADGEEGGDFLPSGKGKADSAECAEKDEDNVRNLERDKKGFAEIVRDWDAWLFVVCQTLAYMCWSFVVVNFASFMKSVGFSADDTSLVLVVFGVAEVAGKILTAFLGDHLPFLQVNALAITSVIGAIAAGFLTLAKSLADLIILSVVSGLMRSTYYGITFSSSFELFGVYGGDIVAALVMVPCGLGNLSAAPLTGALFDASGNYTLSLLVLVGLFALSTVCVLAITIRRKVMSPSTFEKRYRWGRKRQLEQDVKTEEKLPPTRETKNGVCMVTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQD7</accession>
    <name>A0A8B7XQD7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pecanex-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110975150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the pecanex family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083038.1">
        <property type="nucleotide sequence ID" value="XM_022227346.1"/>
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    <dbReference type="KEGG" id="aplc:110975150"/>
    <dbReference type="OrthoDB" id="10037631at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR007735">
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    <dbReference type="PANTHER" id="PTHR12372">
        <property type="entry name" value="PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12372:SF7">
        <property type="entry name" value="PROTEIN PECANEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05041">
        <property type="entry name" value="Pecanex_C"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="53"/>
        </location>
    </feature>
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            <end position="1102"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="1454"/>
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        <location>
            <begin position="903"/>
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        </location>
    </feature>
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        <location>
            <begin position="2045"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010170"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367089"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF05041"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022083038.1"/>
        </source>
    </evidence>
    <sequence length="2201" mass="244177" checksum="8E621BE868A1AB5C" modified="2022-01-19" version="1">MGSHTLEVLRQGLWGSLTGGWYFDPHQNIFCNTLHLYLWLFLLCFPLGLYMAFPPFPAIWASYSLLTALVFSCIKFISYRMHLTFDSGEEATPGEETEEKPSEDSGKGEEAGEIEEIGFGTSGHHRTKFGMEDDAIELEELNSNPQHVASTSGRESSRDSFPPDNEKGAWSDKDLPGTIRLEIHPQKEPPTTSHLDNSLSEALDALNNTNNLKLDSIDGSSRQPGGTETVPAAVFTSHGSPHSRKRRQVRPQDAGQSSSRRRNRMSMGTNTSRGMSSPKGPSSTELGSDADFKTERGVLDSVPASLSTVSMQEPSSGTPQGKLTKRDLESCPHLGLSSITPRADSDSLLAMLTKERTPEQETEVTEEARRRTKSSGSGERTRSRHLTENLTTTTRPTRFSFPDSSARQSLTPPSRRRTASSNRNMSGKKGRHLSDRQKELASPIEENNNELKPSPEMPDKIKKKRTQSPPRHDSSLSTNNYANSSMDGAAPALAHTSAPSETNCSNPCSKNVSDSVSEDSLDLVVKNVLGSGVEIDENCDSSQTITSSKRPGQGAMTSSSDDDSTVVSEHSAFLGSSGNAPSSRSTSSSTGIQWLFSTDGDGPSDKGGEPSSTSKATEREPSPQSRDRAKEGAIPKRKSRLSSSTSQSDEEIKADPDQGQERAGANSSSNRLIGRMMKRVLREESLRFQLEDARGSLNPSIRRARRQARYLSSTSESRQRHQSDRGEGTSTSSLRHRREARQTTHPPSSPHLAALVSVARREGRYMASAHDDSSPGAVHCFQDEHGNWMTYTFDENSTGIAQRLDTEPIPDTSPSDIEKPSIDWPDSSSCHSDSTVITMPKSSGATLDSGGAHSSLEGHLPISILFNQPSSAGGGGRRPSWDLSRHLLSDLGLHGLMEDIRRQNSEQSTRDEAHSLASLEHSGRHHRRSRRHERARVKHNYRFWLLPRRSVRVTFDRLAFLALFDRNRTLLESIIAILLSVLVSILGFAVLSQGYLFDFWVFWFCFVLASCQYSLLKSVQPDAASPMHGHNQIIAYSRPMYFCICCGLILLLDYCGSQPALCQPPPSLYGLSIGGPDLYRLGRDMLIVFVLCFPLIFLLGLLPQCNTFATYLLEVIDVHIFGGNATTGLAAAVYSFCRSVITVLILFGFAVGALKDSAASQHLLFSVFCGLLVAVSYHLSRSASDPSVLWSMVKKFVVSEPQATPEGSQDEIRDPLPGKLQKSVCERLQSDLIICLLYSAVLFGVHASTVFTVLQPGLSYVLFGIAGVLGFLLHYLLPQLRKEMPWLCVSHPLFKSKEYLLFEVRDAAKVMWFERMFVILCFLERNIVYPLVFLCGLTTTGHKITNSFSPIAGAFILTVCGLKLLRSAFSNTAIQYPILVLTVLFFKFDFNQETILLDLFVVNYFLMSIFVHKLHEWILKMKFVYTYIAPWQITWGSAFHAFAQPFSAPHSAMLFLQTLISAFFSTPLNPILGSAIFITSYLRPMKFWERDYNTKRVDHSNTRLATQLDKNPGSDDNNLNSIFYEHLTRSLQATLCGDLVLGRWGTVIAGDCFILASDYLNALVHVVEVGNGLVTFQLRGLEFRGTYCQQREVEAITEGVDDDDGCCCCYPGHLPHFLSANAAFSQRWLAWEVIASKYVLQGYSISDNCAASMLQVFDLRKILITYYVKSIIYYVVRCPKLEQWVTSEIIQEALKDCSEERYTDCDPTFTPKIDEDYDMRQSGISRESFCNCYLGWIQHCASRREEELDSSKASWLVTLCFALCLLGRRALGTASHHLSTSILESFLYGLHALFKGDFRITSARDEWVFTDVEMLRRCVAPGVRMSLKLHQDHFTSPEEYEDHQPLYDAITAHEQNLVIAHEGDPQWRNAVLSNTPSLLALRHVLDEGSDDYKIIMLNKKYLSFRVIKVNQECVRGLWAGQQQELVFLRNRNPERGSIQNAKQALRNMINSSCDQPIGYPIYVSPLTTSYADSSEQLASIIGGPLSFGNIRATVINCWRRIRMRCVTGCSSGGGGPDGGDKDDTETVTGGGANTSHTLNSQGDNTSQPQQGSTGQSDTSSQQLQTPGHNRHSLGSSTGSVGKPGVGRIPLASLFGDSAYPKDPYLAHRVRIMDPSMVYEKLHTSKFVMWPEESMRSAGGRNAWKGWNPEEGMEGTVVHTWVPCHRDQSRRSHIDKTILLVQVGARYVPILEAAVLDLGAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XT01</accession>
    <name>A0A8B7XT01_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Metalloendopeptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC110975648</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Metalloprotease.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_022083987.1">
        <property type="nucleotide sequence ID" value="XM_022228295.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083988.1">
        <property type="nucleotide sequence ID" value="XM_022228296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XT01"/>
    <dbReference type="GeneID" id="110975648"/>
    <dbReference type="KEGG" id="aplc:110975648"/>
    <dbReference type="OMA" id="HETCERW"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04280">
        <property type="entry name" value="ZnMc_astacin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000015">
        <property type="entry name" value="Meprin A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1940">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034035">
        <property type="entry name" value="Astacin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF883">
        <property type="entry name" value="ZINC METALLOPROTEINASE NAS-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01549">
        <property type="entry name" value="ShK"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51670">
        <property type="entry name" value="SHKT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044519720" description="Metalloendopeptidase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="16">
        <location>
            <begin position="85"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="281"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="420"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="536"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="588"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="633"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="676"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="740"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="777"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="ShKT" evidence="15">
        <location>
            <begin position="818"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="856"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="874"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="897"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="372"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="420"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="536"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="588"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="633"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="740"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="777"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="818"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022083987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022083988.1"/>
        </source>
    </evidence>
    <sequence length="924" mass="105386" checksum="B4DABEA65AB09400" modified="2022-01-19" version="1">MDAPRHPWFLLFILLSSIACTASESGVIVGPPAPQTLDAGPDAMETIIEQNEAIFEEIAEGKKNHFIVDGDIYDPTANQTRKRRNAITDRRRLWPGGVVPYVIDGYFSTEQRVFILSAMQRFHEKTCIQFRPRTIERDYIVITEGEGCWSMIGRRGGRQTVSIGGTCKNSRGTIIHELMHALGFRHEHNRPDRDNYVVLYWQNIDKKMWDNFAKYSRRDVTLLDTGYDYLSLMHYPTYAFSKNGGQTIGTIYPTYEEPGTRNDFSYVDVYRITALYRCGACYDTDKDNCPTWAIMGECRRSSVWMQKYCPFSCESCNKAEYSGGDCRDYSNNCEKWSSHGECDRNPDFMSYNCKMSCGYCKAPNDVHARRECYDDSPLCGDWSQLGECYNNPEYMKKTCHKSCGVCVETDRDHTVGDGDCRDLHPLCHIWARHGVCQSYPEWMMENCALSCWRCANKTGVTVEIWDDTTTETDGSGTQKPPARRRQICQNKMRRCDQWADNGRCTREPDFMYKRCLKSCGMCIDERVTGVKGTPPCEDRHSLCNIWSQEGDCQHDEEWMRVKCPISCGYCSMATVLTTAPTAKQRNKCADRFTTCKLWAGNGECDIATEWMEKNCPKSCDACPGEVEEAHQDCTDSYQRCPAWAAKGDCQYNPGWMNVYCRKTCQRCHERKTLPGCLDHYRRCKRLADGGGCRGDNSRWMRSNCPLSCGFCGVYDRAPPPPAPALNESTPAELNSTGGVCRDYHPHCQRWYQNGNCHVNVRYMKNHCRKSCGYCPTCFDKDANCRVWAKRGDCLSNPLGLAKACALSCGNCGRGPTECSDTHKQCPKWAKRGYCDQNTNFMHKFCKVSCRVCDSDETATQEPPTETVREGRPQAKSKKKTKGSNKNRRRPATSSTKRPQKGSTRPRKNKRPRKRNTQGRDAELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XT05</accession>
    <name>A0A8B7XT05_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 37-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110975652</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083994.1">
        <property type="nucleotide sequence ID" value="XM_022228302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XT05"/>
    <dbReference type="GeneID" id="110975652"/>
    <dbReference type="KEGG" id="aplc:110975652"/>
    <dbReference type="OrthoDB" id="7788172at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001370">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409:SF295">
        <property type="entry name" value="AZ2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24409">
        <property type="entry name" value="ZINC FINGER PROTEIN 142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="328"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="450"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="634"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="730"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022083994.1"/>
        </source>
    </evidence>
    <sequence length="800" mass="90881" checksum="4E0C6AD0CA4B0E15" modified="2022-01-19" version="1">MYYNTMCDALLVPKHRLAQVDSLTVLRYGWSPGYKGLKVIMEDPDDLHVCLKCHDQIVGLDNYIEHRRSKCLGKPKEDGNSSGAVEDTEETVAQIPSGISQEKETSTNNVLEEDTNKSMAVEEPTGTSTATQNDGKLDQQQRKRGRPKKIPSTPIGEGSAEMKKGSGRPRRMKRPPLLSHLYVDFPGGLQEKKKAKTRQPVNPKRLRVPVYEPERSESGTGSESEDEKGTRNLGSKTSNRGRKPKIPLTEEEETLLAKSKVKNLYQCKPCGFSTTNKHSQLKHFRTIKHLESIGSGNPDSVFRCDECPVRFFSEQGLQRHKIRHEQQCRCSKCDAEFETRRELQNHVKTEHAQEKPPRERDGGSLEACKECGKHLSKAYMKIHLRIHTGEKPFACDICPFRFNQLGDLKMHMKRHYGIKDHKCSLCNFVTVKASILKNHMKLHTKRERTEACHLCEQKFYNQGLLKSHIRLKHQPSRIHECTFPDCTYKFKFRMELVTHMRKHTNEKPFLCSVCGYSGSTKQALSRHFRKHTGAKPFKCDFPGCNYMGRVSTHLTRHKRLHTGEKPYKCPYCSYRANTHENVRKHIRGTKKHAGFAVYVCKFCSEMKTDLYQELVDHMRQVHADDYVTFDQVSHQSGLLADKEEPPNEASGKPDTQEDTREAEEMDMATNKLSQDLQLATEVDQNMQVSAATEGNGQDLKIVVSDSQVVGEAGQDLCKEYILCQVIQDGRQQQPQRQEGGMEAGTEDTERSEGAVAEHPGEIQEIQMVAVEEEQATEAIEMILRQAVSGGSGGSQEYIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWD4</accession>
    <name>A0A8B7XWD4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Gamma-aminobutyric acid type B receptor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18 19" type="primary">LOC110976318</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085182.1">
        <property type="nucleotide sequence ID" value="XM_022229490.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085183.1">
        <property type="nucleotide sequence ID" value="XM_022229491.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085184.1">
        <property type="nucleotide sequence ID" value="XM_022229492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWD4"/>
    <dbReference type="GeneID" id="110976318"/>
    <dbReference type="KEGG" id="aplc:110976318"/>
    <dbReference type="OMA" id="GWWRIET"/>
    <dbReference type="OrthoDB" id="2150267at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038039">
        <property type="term" value="C:G protein-coupled receptor heterodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004965">
        <property type="term" value="F:G protein-coupled GABA receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15047">
        <property type="entry name" value="7tmC_GABA-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06366">
        <property type="entry name" value="PBP1_GABAb_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000063">
        <property type="entry name" value="Gamma-aminobutyric acid type B receptor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002455">
        <property type="entry name" value="GPCR3_GABA-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519">
        <property type="entry name" value="GABA-B RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10519:SF74">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01177">
        <property type="entry name" value="GABAB1RECPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665483" description="Gamma-aminobutyric acid type B receptor subunit 2" evidence="14">
        <location>
            <begin position="32"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="722"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="15">
        <location>
            <begin position="480"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022085182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022085183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022085184.1"/>
        </source>
    </evidence>
    <sequence length="810" mass="91729" checksum="9DD936D229ED30E8" modified="2022-01-19" version="1">MHSHGFQTFVQVAVCALLFQHLGLSPPAAWALRTASEWPSRNKTPIYIAGFFPFSDYFNDMLVNSTEIAIDHVNEFQDLLADYELRMIWNWTQVEGENSAAPSLKVIYDFIYNQPQFLMTWGPVYSRVGEVLNEVIRRYNLVQVCIAQFVSNERHLEKYPLTVQIYPSSGVFNPARIVLMKQMGWKRAAIIFENYDLFRAEMEELDKLLQDHGLTTTTLEAITGSDPSANVQNLKKHDARIIFGSFYQEMATRVFCEAYRKGYYGPKYVWILLGWYSPVRWWVQEIDKFVKNGEDICTAEEVEKVVVGSLSIRGFEIQTDMSKINFNGVRPLEKHLDFYADLQDQLLTAGACDSYGYDQIITIALALNASIQALAEMDPPRRLEDFTYEDTAMSSVFLEKTRSVDFVGLTGRVAFDEYGARESDAVVQQMQDVGSNKQVFKYDGLTEKVTQISEFIWAGGFKPVDGPTYSKTQLRIQESIKIVVFVLSGLGMALSIVFLGINTRFKNRSAIKISSPQLNNMIALGSMLLYASTFLLALKIEVKEGDFNGRIYCQLSSAALCIGLSLAFGALFMKTYRIHHIYTSAMKVRKVRATITDSKLMTSIGLFVLLDALIFVTWILVDPIHVETIQLSPVLRDERTEKYDVPTMSYCTSAKELYFAIAIFAYKGALLIFGIFLAWSTRNVRISQLNDSKHIALSVYTVGLTCVLTVPVAYFSQARGDINFVFAFVCGALFVANTIVLCLVFIPKFISLKTTEGARINTFMPSSNFTISQDKQATISRLRQLLEEKNTRLETLLHQLEKLVNTELVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWD9</accession>
    <name>A0A8B7XWD9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General vesicular transport factor p115</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein USO1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Transcytosis-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Vesicle-docking protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110976302</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VDP/USO1/EDE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085188.1">
        <property type="nucleotide sequence ID" value="XM_022229496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWD9"/>
    <dbReference type="GeneID" id="110976302"/>
    <dbReference type="KEGG" id="aplc:110976302"/>
    <dbReference type="CTD" id="8615"/>
    <dbReference type="OMA" id="GQETFCN"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045056">
        <property type="term" value="P:transcytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000054">
        <property type="entry name" value="General vesicular transport factor p115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041209">
        <property type="entry name" value="P115_Arm_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18770">
        <property type="entry name" value="Arm_vescicular"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="21">
        <location>
            <begin position="359"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="959"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="665"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="734"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="965"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022085188.1"/>
        </source>
    </evidence>
    <sequence length="987" mass="110308" checksum="191FA071BE226C8B" modified="2022-01-19" version="1">MSWFRSVLGSSDTAAQPSGAETIARLCDRVKSSTLLDDRRDAVRALKSLSKKFRFEVGTQCMEVLLGILQTDRSDPEIASYALETLLNIICPTIEEEDDDYEHIDVDAREREIRQLSEHFVDIFLNKTENITLMLGLLEEYEFRIRWPAIRLMTALINLRSSQVQQIILVSPMGVSKLMDLLSDSREVIRNDGLLLLTALTKGNANIQKIVAFENAFDLLLRIIMEEGGSDGGIVVEDCLQLLLNLLKKNSSNQTFFKEGSFIQRLSPFFELQTLVPQNPDGTWSTQKVKNVHHMLQVIRSLVSPNNPQQATSACQKLIHSCGLLKQLCSILMASGVPADILTETINTVSEVIRGCKVNQDFFAAVNAPSTPPRPAIVVLLMSMVNEKQPFVLRCAVLYCFQCFLYKNEVGQEQIISTLLPATADVSAVTAGQLLCGGLFSQDSLSNWCAAIALSHALKDNTAQKEQLLRVQLATGLGQPPVSLLQQCANILSQPTVRFQTKIGLLILLSSWTAGCQLAVTHFLLNPANVPFLTAQVAEHADEHELLGQGLCAFLLGICVHFNDNSNESFTKENMKQLIVKRVGLESFVEKLDLVSKHELYTLAAQKPQLQFPSPDVMMLDYEFTTLFKQLEGVLLKAVSDKDDVETKKTIEDHDSIVTQYKEIIREQDVQLGELRTKYSSLEREHKKAEALLGEQGLQIQQLKDQYALIKAQHGVQSGQGDVNNSIDSASLASGSDRERVAQLEAEIAALKEEKATLSTQVEEKNARIEKLTNDLTISDAKAVLSSNDMENTSSDELRTHLEEMQKKNEKLRMALADATAEIEKQSKMVEELSEKERSSRDIFSREMSDLESRLAQSESGHASLVAENEQLRSTNQMLEAGHLEAQNASQRASSGDAEAINQLKEAVNQLQQEMKVLEQERDSVKLELEDVRKEQDDVLVLMMETESKKDKYKEKLKELGQTISDDELGEEGEDWEDEEEDEKEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWF7</accession>
    <name>A0A8B7XWF7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Solute carrier family 22 member 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110975996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022084587.1">
        <property type="nucleotide sequence ID" value="XM_022228895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWF7"/>
    <dbReference type="GeneID" id="110975996"/>
    <dbReference type="KEGG" id="aplc:110975996"/>
    <dbReference type="OMA" id="MMFNWMV"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022084587.1"/>
        </source>
    </evidence>
    <sequence length="370" mass="41677" checksum="AB0006696426621A" modified="2022-01-19" version="1">MVSFGHVFFAAENDHWCQVLPAENCSNWVEFQDKCTNVKKSILLPPPENENSKYPHSNCKQWDLPPGYEFDPYDPLSQGANFTNDTVPCQDGWEYDTSQYKTTIISEFDLVCDKRSLPSLAQSIYFVGFLVGSFLCGSLSDWIGRKKTAFVALLFFSVGSIVTTFSVNIYMYMAFRFMAGFGNIGSYIPLFVQESVNWLVSKGRIEEANKVVRRVAMINGKALPDVLFDKEDMEETESSVPPSFIDLFKTPNMAAKTINMMFNWMVTTLIYYGLSLSTGDLGVDEYWAFFVSGAVEIPAILYATFAIEWFGRKLNVTILEVIGGVACLANIFIPLGIWRTVVSMAGKFCITATFSIIYLYVTELFPTPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXT9</accession>
    <name>A0A8B7XXT9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proline-serine-threonine phosphatase-interacting protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110976009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084606.1">
        <property type="nucleotide sequence ID" value="XM_022228914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXT9"/>
    <dbReference type="GeneID" id="110976009"/>
    <dbReference type="KEGG" id="aplc:110976009"/>
    <dbReference type="OMA" id="KNYEARC"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000037">
        <property type="entry name" value="Proline-serine-threonine phosphatase interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF61">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE-INTERACTING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="354"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022084606.1"/>
        </source>
    </evidence>
    <sequence length="423" mass="48021" checksum="5CB46A64113E9282" modified="2022-01-19" version="1">MSRFVDSFWDTEFNSTNGYEVLLKRMKEGREMCKDYEDFLKQRAKAEESFGKTLLKISRTSGGKEEIGTLKAAWSEVVTQTELCGQAHIDISIRLGDEAKKVEEFRESQKDLRRKSEDAIKKLITAKKDQYNKVVHSKRNYESKCKEADIADDSYMKGRLVAPAKEIDKMALKKDRTRQAASVADAQYQKDVASLDQTRQQWEEQMAQLCVIFQQLETERIRFLRNAMWVFANIISLQCCSDDGNSEDMRKALSECHEDKDIQLFISQKRTGSSRPAPIVYECYYRDNMMGKSGGGITNSRSRQTLPPIPGGPPKIDQTRALPSPPPQSPPNHAGIYSSMGEYSTGVVGESSSIKTNKFMAKFDYDAQGPEEMSIKAGDILTIIDREDETWWYAELDGRKGHVPAEYLGPYANTGEELHNTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYA5</accession>
    <name>A0A8B7XYA5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras-like GTP-binding protein RYL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085874.1">
        <property type="nucleotide sequence ID" value="XM_022230182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYA5"/>
    <dbReference type="GeneID" id="110976691"/>
    <dbReference type="KEGG" id="aplc:110976691"/>
    <dbReference type="OMA" id="WHEELYK"/>
    <dbReference type="OrthoDB" id="10027888at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085874.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="25835" checksum="A8FFC1424D3A6212" modified="2022-01-19" version="1">MSLSRAREDAYEKFDEELDISYHIRIAMVGDAGAGKTSLLLRYTDRNGSRTPSDHNIDVRTKMLIRNGRRIKLEIKDTAGLERYRSLTRSHYSAITGALLVFDLTNEMSFQHLTYWHEELYKNADKLVQAILVGTHCQNENREVAEDSIRRLAEHFDMPYVEVCSQANSNVDYCFETLVDRIIEKHSERVNVQKSERIQLRDESDTSRSFSRCCTIIHPKESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYB9</accession>
    <name>A0A8B7XYB9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate transporter 13-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110976702</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085893.1">
        <property type="nucleotide sequence ID" value="XM_022230201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYB9"/>
    <dbReference type="GeneID" id="110976702"/>
    <dbReference type="KEGG" id="aplc:110976702"/>
    <dbReference type="OMA" id="QEASWPM"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF303">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022085893.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="44943" checksum="2FEDD4A43158A30C" modified="2022-01-19" version="1">MDTSAELDANGWFTVLTSFSNVVLWGGIYKSLGVLLPTLTEQFTDHTWLTGVAISFMGLAADISGLLTTLLEDKFGRRRMLILSTLTVCVGLMLVPLATSIVHIAIVLAVVVGPALGISSVLSKVLLGRHFNKRYTLASGISQMGQVVSLLAFAPMTQLFLDTYGWRGAALLLAGVCLHSVVCPVLVKEEKERYETPPDQHDHKETNSTGMTRVKSFFAHALSTVDLRILREFNFWIVFTCICGARFPGNAWFLFNVSHLQAKGFSPQTSAALCSAASVGYLVGCVMFSPLVDRGFLKCSTGVLISSLLLTLSLAIDPFLHEAWSIAVFTALFGLSSSALYALTDVLTKELLGRERLTSAFAWIGALGVPAKLLAGFLPGWLYDSSGSYDLAFIIMGASPTVAAIPLVIGKFWKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZH9</accession>
    <name>A0A8B7XZH9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sigma intracellular receptor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transmembrane protein 97</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110976910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086308.1">
        <property type="nucleotide sequence ID" value="XM_022230616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZH9"/>
    <dbReference type="GeneID" id="110976910"/>
    <dbReference type="KEGG" id="aplc:110976910"/>
    <dbReference type="OMA" id="EFKDPMV"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="11">
        <location>
            <begin position="9"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022086308.1"/>
        </source>
    </evidence>
    <sequence length="187" mass="21651" checksum="7EB2633C827DB2BC" modified="2022-01-19" version="1">MAKGLTRVLEWVIVVYFASHIFITVFFDSQAIMPQWLYPKMFVDVMKDYSVYMKDEMMADPSAYPWFMSFVYGECLLQFPFFFVATYAFYKGSCKWIRIPAIIYSVHTATTLQAILAHILFQDFSKSPYPAPSTLEERLKLSAIYVPYLLLPVLILLLMLFSSDYKPAANKPATNTAAPRTRKQKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y033</accession>
    <name>A0A8B7Y033_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13 14">Bridging integrator 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15" type="primary">LOC110977047</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in cytokinesis and septation where it has a role in the localization of F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022086512.1">
        <property type="nucleotide sequence ID" value="XM_022230820.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086513.1">
        <property type="nucleotide sequence ID" value="XM_022230821.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086514.1">
        <property type="nucleotide sequence ID" value="XM_022230822.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086515.1">
        <property type="nucleotide sequence ID" value="XM_022230823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y033"/>
    <dbReference type="GeneID" id="110977047"/>
    <dbReference type="KEGG" id="aplc:110977047"/>
    <dbReference type="CTD" id="55909"/>
    <dbReference type="OMA" id="TRFCAYF"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000028">
        <property type="entry name" value="Bridging integrator 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="BAR" evidence="10">
        <location>
            <begin position="12"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022086512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022086513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022086514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022086515.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29650" checksum="C465820564074CAF" modified="2022-01-19" version="1">MSWNIFSRLTSPKKAPPVITKEEEKAFEREVNKISVLDEATKKLYKDMKHCIEAMGALSKSQCRIGQNLAASPILNTEESLKNLELISKSIGQIESKTQELNASSMRTMVEPMKKFSTIFPSLYMALKKREQCLQEYSRCQGKVEKYQDRERTGPNLAKLEASKKNLAAAKEEYDRQHTELMQAMPQFFEGRVEYFQPSFEALIKSQVIYYTECFKIYAELAVQLGDNDTLQSDEDFEMDLHRRLCEIRALSIVVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0A7</accession>
    <name>A0A8B7Y0A7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Peroxisome proliferator-activated receptor delta-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110977089</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086594.1">
        <property type="nucleotide sequence ID" value="XM_022230902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0A7"/>
    <dbReference type="GeneID" id="110977089"/>
    <dbReference type="KEGG" id="aplc:110977089"/>
    <dbReference type="OMA" id="RKIDYRC"/>
    <dbReference type="OrthoDB" id="7634782at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06965">
        <property type="entry name" value="NR_DBD_Ppar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050234">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001728">
        <property type="entry name" value="ThyrH_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24082:SF497">
        <property type="entry name" value="PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00546">
        <property type="entry name" value="THYROIDHORMR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="12">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="13">
        <location>
            <begin position="135"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022086594.1"/>
        </source>
    </evidence>
    <sequence length="388" mass="45039" checksum="F61B27707224D538" modified="2022-01-19" version="1">MESSATSTTNGHDPGRHFALDNMDLPLKCRICGDKASGFHYGVHSCEGCKGFFRRTHRMKLQYKPCPYSKARPCKISLSTRNKCQYCRFQKCIAVGMSHDASRFGRMPREERLRLLEELNQEEHEASEEDKRRAELRALTERIHQAYKDIWALSFHPTLEARTNKLMEERLGIIEEANVNIDSRPMRELTDINDIAAFLRNALQTAIESLAQFAKRLPEFRSLDINDQVSLLKHAGFEIAMIATASRYMADGLWFPSGGVYFKKRLLEGLDTMFFEDKFRFFEKMKKLNLTEKELALFCVLALAAPDRDDLTQREQVEKFQEVILEALEWEVQQNHHGNPLVLPRLLSRLVDLRQLKLEHVQQIQQLMLLDDPRYNGPTPLMMEVYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y192</accession>
    <name>A0A8B7Y192_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110977268</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022086933.1">
        <property type="nucleotide sequence ID" value="XM_022231241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y192"/>
    <dbReference type="GeneID" id="110977268"/>
    <dbReference type="KEGG" id="aplc:110977268"/>
    <dbReference type="OMA" id="VQDENMA"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000091">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000004">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="340"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="662"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022086933.1"/>
        </source>
    </evidence>
    <sequence length="817" mass="92799" checksum="3B22325D549D5C0B" modified="2022-01-19" version="1">MDVADQRTGVAQVKDAVAEKCQKLFQDFLEEFTVDGELKYQQGVEELIRPERNTLTVSFDDIQHYNQQLATTIQEEYYRVYPYLCTAVRNFARDRSQIPPSKEFYVAFEDVPTRHKVRELSTAKIGTIIRISGQVVRTHPVHPELVSGTFVCLDCQTVIKDVEQQFKYTQPTICRNPACFNRNRFMLDTNKSRFVDFQKVRIQETQAELPRGSIPRSVEIILRAEAVELPQAGDKCDFTGTLIVVPDVSQLSVPGAQQESSTRSKGGEGYNHEGVRGLKALGVRDLSYRLAFLACNVTPSNPRFGGKDMRGDELTAEAIKKQMTDQEWQKVYEMSQDKNLYHNIITSLFPTIHGNDEIKRGILLMLFGGVPKTTMEGTSLRGDINVCIVGDPSTAKSQFLKAVEDFSPRAVYTSGKASTAAGLTAAVVKDEESHEFVIEAGALMLADNGVCCIDEFDKMDVKDQVAIHEAMEQQTISITKAGVRATLNARTSILAAANPIGGRYDRTKPLKQNINLTAPIMSRFDLFFILIDECNEVTDYAIARRIVDLHARNKESVERVYCVEDIQRYLMFARQFKPKITKESQDFMVEEYRRLRQRDSSGGTMSSWRITVRQLESMIRLSEAMARLHCQDEVQPKHVKEAFRLLNKSIIRVEQPVINFEEEEDMEPELEPEDKDNAMETDTPATPVKEPEQPPAKKKSLQVSFAEYKTTAKMLATFVRQQEEKEEEGFEGVHRSELVNWYLHLKESRGEIETEAELIESKQKVDKIIDRLIKTDNILIELAKTGLKVRKGDKEPEGIVEEPDPLLVVHPNFDIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y354</accession>
    <name>A0A8B7Y354_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110977630</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110977630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087613.1">
        <property type="nucleotide sequence ID" value="XM_022231921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y354"/>
    <dbReference type="GeneID" id="110977630"/>
    <dbReference type="KEGG" id="aplc:110977630"/>
    <dbReference type="OMA" id="FEACTIA"/>
    <dbReference type="OrthoDB" id="10060112at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd10442">
        <property type="entry name" value="GIY-YIG_PLEs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF11">
        <property type="entry name" value="GIY-YIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="347"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022087613.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="51677" checksum="B2A76D452377D220" modified="2022-01-19" version="1">MPDMMTGSDHASRGGPSYNTARHLTKILHPLVGNTPHHIKNSDQFAQFMDGLSLRPTDVMVSFDVVSLFTNVPTFEACTIAKDRLLQNHSLSNRTNLTPHQIHNLLISCISSSCFQWRDKFFEQSSGTSMGSPLSPVLADLFMEEFEQTALFSADLKPSVWIRYVDDTFVIWPHSPQDLQLFLQHLNSQHNDIQFTMEKEQVGRIAFLDVEVSRLPDGTLSRTVYRKPTHTDHYLNNRSFHHPSIKASVNRALVRQAYNVCDQDHLQPELHHISTALKRNGFKSRHIKTLDPPQTSGSPIPKVNPLGNTSHWIQRILLYHGIKVFHTASNKIQATLQSHKDKQDPTTKPGVYRIPCECGKVYIGETGRDLTTRLNEHRAHGRRGHLEKSVIIKHSSTEDHQVHRQQAHLIANIEQWHPRRVREAIEIHKNRTVLQDTGFTISDIWRPILNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3T5</accession>
    <name>A0A8B7Y3T5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086980.1">
        <property type="nucleotide sequence ID" value="XM_022231288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3T5"/>
    <dbReference type="GeneID" id="110977299"/>
    <dbReference type="KEGG" id="aplc:110977299"/>
    <dbReference type="CTD" id="6138"/>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022086980.1"/>
        </source>
    </evidence>
    <sequence length="204" mass="24036" checksum="D0C862FBA58A3A28" modified="2022-01-19" version="1">MGAYKYMQELYRKKQSDVMRFLARIRTWNLRQLSAVHRASRPLRPDKARRMGYRAKQGYVIYRVRVRRGGRKRPVPKGATYGKPTNQGVNQLKFQRSLQSVAEERAGRRCGALRVLNSYWIGEDSTYKYFEIIMIDPFHNAIRRNPDTRWICNPVHKHRELRGLTSAGKKSRGLGKGHLYKQTIGGSRRAAWKRRNTLSLKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4J1</accession>
    <name>A0A8B7Y4J1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110977889 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110977889</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088108.1">
        <property type="nucleotide sequence ID" value="XM_022232416.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977889"/>
    <dbReference type="KEGG" id="aplc:110977889"/>
    <dbReference type="OMA" id="THCEKIT"/>
    <dbReference type="OrthoDB" id="6061841at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897:SF2">
        <property type="entry name" value="OS03G0226600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16897">
        <property type="entry name" value="OS10G0105400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034466522" evidence="3">
        <location>
            <begin position="25"/>
            <end position="3304"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="5">
        <location>
            <begin position="3214"/>
            <end position="3304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2179"/>
            <end position="2212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2181"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022088108.1"/>
        </source>
    </evidence>
    <sequence length="3304" mass="357995" checksum="52482FD35EDA75A0" modified="2022-01-19" version="1">MADMRNVIVIALVATFLTLSAVEAFTCYGSTTCPNGGTCIEDDLCACVQGYFSPRCEVCRPIDHCPEVFCSNYYDAKCIRCDGDFGPTFGSAYEKTGDQRRCIKQCSWRSDSNACFPGSCTDAQCTCSSGFSGDDCRTMEEGQAPVMSELRATLLAGTTTQELGRARNDTATLDINGQNFTDVRIHWKCSYQPTGLPNPSVLDGAGQPVYPYIANVSLGVVSASVTATVHLASGGTYTLGSENCPAAGSQDDPATSLVICEYTFDIDGSIWTPSDGDVLTYIVDATNGGYMQLYDRDNSNNIITRYYVGRTVSASANFTFDLDSPYHCVNVSAGCRTTMLDAGDDVTVEADITITWSDWADDLSGIGEYDLQVRQLSGGHGDEMTETFDVPAVYAGAAVSGQTVMLPHPGVYSIVLTASDKSGNTRLSRRFVLFDDDPDDVTTQSHAPLRVLSASTETGYTWVTDLGLPGGTTPITLSWFEHFTNAHHRSQGLLKPIGSYAGGEIDTAYDQNFGLRGRAAIPNALGVTQFRVLYDIDHSGGRTIVNASRNDSDDWRNLNTTTQVTYDLSLVDGDSIRFWVEARDVTGHSLRDTVLTHVDSSPPVVDGGDGTLAVPSSADLDNVGVAFRAYDVHSGIRTIEWRIFINQSDTEVELARQTLPPVKIDPATEDCDPSSCLCIPLGDCYAMYYGFNPDVHIGGHSSDYFVGLTVTNHARLVANKTIKVTVDSTPPEAGVVHDGMLGSKEVDYQVGRDLWAHWEGFVDRESGVAFYRYLFDDLCWDDSTAIDSVQDNMTQTSSTHASWTAPSPGKYHVTVVAYNTAQEPSEPVCSDGVTIDASPPELSQIAIKRTRAWPGLAKDAEGRVWLITEHLRKMELVNASSNCSSVATPLTDLSIYPDVTASEARSQQDISCQDFSGFEEKLFLPTHKHMTVSWSGEDLESSIYDYEIGLSSDLSNLTPDLVTFVSTSGHDRFVMYHPHISHGSVFYLVLQAINKAQVSTTKAIGPIVVDTTPPTFVGRVSVRADDDHLIAEWGDDGFIDDEDTGLRYQVAIGQHRGGTETHSYQEEDDLQIGPCLLRTSCAAFSLADLGWRLHGDHEYYVSVRAQNGAGLVAVGISPVYRHIVQLPSVGVVLDVAPLGEAPDGTLGVAKDIDVQMDTTSISARWYGFEHPHLDINYEIAVGSEGGTSDISGGLIDVGSATFYRLEGLTLTSLKTYYVTVRATSDTGSVNVTSDGVKVIREGLILDGTAVKDGLGCHREGDEVLSNGSSDADPPCQDDIPHQSSTSDISARWTIPEMLLPFVTHVLWAVEEEVETYTDDEVAMSEWIQVIDYQDLGMAFQHVEAGVRLRDGAHIRSKLKFCHGSVCFLPVTSDGFWVLSRPPEVGQVTVSDVRLADGLTNLSVIFQPFVHEYVRRGDQRELMDGYQWRIAVAGGAVLSAWNLAGDVVIAGETAHFIATYNGQLDRRVCHQLSLRGFNKAGLSSTASTQLPDCAVLSAPNIVIDADHEVVLELNAAWHEPDRDYVLSRTFLAAVWPQLRHRAYVWAAVQDIGTADFGNLDQGLHFPCEHPMAEACGETDKEFVNIPGLSLQHSNRYRVCVHANQVVIEHETWNQTLPSVSSCSDGVVVDTTPPIAGSVRMGWQQRQKFQRSSSELVLHWESFTDSEEHGSSWQHTGIQYYEYAVGSSRGSSDVKEFTRLGLTDSVIVNNLRLEHGHSYYATVRAYDFVGLFAASTSESIIVDAMPPTVNTSYTLDIGGSFIRSTTSLSARWEHVFSDKESGIAYYEWAVGSQPGHADVMPFKQETSESGASDPSAPLRLQEGHSYFVTVKAVDHVQLIRSKSFGAFAVDASPPLAGHVFDGDPTQAPVSHRDQDFQGDRAALGASWEGFHDPHSTLVGYSWFAGTCEGCSDVVPRQHVGLDTSVLADNLNLVPGLTYYVTVTACNAAELCTSVTSDGVTVDDSPPVWGHVSDGGPGGGDVSFQSSRRELRAHWWGFHDPHSGLSHYEWRAGTTPGAADILPSTRIELSEDALIFLPASDQLPVGNDIYITVRAYNRVGLQSEATSNGFRVDPSPPDVVNIPAVDKTVGVAVQNTQVLRDVVRLSWCFRDPESGMKEQYISVSTHRNGDIDIAPVKVAGSERDHTFTNLTLSDGGHYFMTVVACNYAGLCTEAKAEPLLVDTSPPSQGSFSTAANPEPTTSVPGATSPPSHHSGWMTWLEDSSTSTGSLALAWLGFADIHSGISHYLVSVGTTYGGSELTPGGPIPIDHRNGSVPLDDDTLQTTVIPLEGSITALVPPYLYISMWAVNEVGLSSTHLHSAFEASPTSPHEGALLPLQQCSASTCEGHCACPSSNQACSMRPGVCNDVTNSNPNAEIEVLDILNLTFDDDDAEIDINDTATQYLMAAAWRVSDQKGLGIKWSECSIGDDSSTPSDPAGVFDPATEKIWFDVGQANHTVITLAKDHKLTKGTRYYFFVRAWYDADTFAVFRSDGITPDVTPPKVSMTSRFKVKDLTRPDSSRDADYLTNPSIVYIAWEGAFLDDAMSHYEVSLSTYPGGGDVCYFSNHSVPASEFTTSLANLNLHSGLRYYANVRAFNKAGLHTLRSSDGFVVDTQRPYPGVVNDGIDLHDLEYQNTSTVVSASWHGFVDLESYIDHYEWCVGQTSNPTDDSILPCTDVGIHLSASTTLVLPLNEGNRYYSKVAAVDAAGLQSEMISSDGFVVDTSPPEPLEHILLGENLLTNPSFEGMEGQDSVLPWDVELGSEFTVITSEVKAAQDGSRFLSVRGSVSQTFHTLPGSHYQVVLFASHVVPSHNPLLNQEGHIEAPGLNRVFRLYDQPAHGHSEQSLSSIAWHQHRFFFTASGDVSTLKISSLGLSNGILLDNIQVRLVTTAPSTGNGSVEVHTQFIHGWSSLQAKWHFVDPESPIVDYSWAVGTTRGGTQLQRFTSVGTQTDGANTNLSMQHGSRVHVTVTARNAAGLVAVATSGPIIVDSTAPIIHYVIDGGTEQDIDYSSDDQSVTFSWSATDPETGIDHCEWSVGSQPGFADISPISQTPDAASIVTANLAEASVEGESLYATVTCYNRAGQQSTKSSNGITVVTEPPSNTAAFVLINSVSETPYQSRERYQSQRDSLKASWDGFTDPYGIQHYECLLGGPNAFASWRPCGSTSQTHLDWSGLSLVDDASYTLSVRAVNHAGLTSRAATQTFSVESSWPAVHAPSLLRSSWLGDGTVDLAWDGLFSNPYSSSLVYEVSLGTIPGGSDVMQWVETTETGMRVSPLAPYTDYHLTLTAINAAGLSQTVNKILNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6V5</accession>
    <name>A0A8B7Y6V5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Uncharacterized protein LOC110978332</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110978332</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MS4A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088947.1">
        <property type="nucleotide sequence ID" value="XM_022233255.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088948.1">
        <property type="nucleotide sequence ID" value="XM_022233256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6V5"/>
    <dbReference type="GeneID" id="110978332"/>
    <dbReference type="KEGG" id="aplc:110978332"/>
    <dbReference type="OMA" id="RIGIDVC"/>
    <dbReference type="OrthoDB" id="10071849at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007237">
        <property type="entry name" value="CD20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030417">
        <property type="entry name" value="MS4A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320:SF165">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23320">
        <property type="entry name" value="MEMBRANE-SPANNING 4-DOMAINS SUBFAMILY A MS4A -RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04103">
        <property type="entry name" value="CD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022088947.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022088948.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="28840" checksum="8C78A75B7215753A" modified="2022-01-19" version="1">MSYPPPYEEFHREQQTDTQQQQQQTTVMIQPNPSASHQSSTRGSWKGLQITGYLHVVLGIVSVLFGILASVYKVFLYAIGIPIWTGIIFYIVTGVLGIAAGGKQRHSLVIGYMTMSIITAVAGCAVCVTHGIGVTIGGFQGCPDFGAYYSPFNFGCSSTSGTRAAINGLISALGVTEMIVAIVGASLCCCTFCCVRTPSQVVTYTPPQQGMAHFAVPPEVHLGNVVYPPHQVAMYPTQPQYPVQAIGQVMYPPTTPGQAQALPQEKPPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6W9</accession>
    <name>A0A8B7Y6W9_ACAPL</name>
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        <submittedName>
            <fullName evidence="4 5 6">Uncharacterized protein LOC110977876</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6" type="primary">LOC110977876</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
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            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
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            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-04" db="UniProtKB">
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                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_022232392.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF74">
        <property type="entry name" value="PTB DOMAIN-CONTAINING ADAPTER PROTEIN CED-6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="196"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
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        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
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        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
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            <dbReference type="PROSITE" id="PS01179"/>
        </source>
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            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022088086.1"/>
        </source>
    </evidence>
    <sequence length="329" mass="35919" checksum="094CB7680504DC71" modified="2022-01-19" version="1">MPTQAVPAIRFTMSDNGAATTPLPLPPPMVTLSTEPESRSPTHPKTKKNLLSTLKNSPSMLRRRMKPPLLNHNNRNSWDTTDSASSASSASSSSFTAKEFHVKYQGRVRVTTLQVSEAVNAVKKLAPELTASSSASSSTEDLLNVSPASSLTSLSSPTTLPRAPSPTSPKSPRPAKSPKSLNKSCCLSISKQCVCIDDEERLVNETIPIATVAYCATDLRYPRAVALICKTHNSVLMCHVFVCTSREKSEKIVAFIGKAFESAWQDWKTVHDPATLGTNNNYECFIRGRSRSHDMSRTGRTDSPSDTTPDRHSSYEIRNDEFSSSPDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7G7</accession>
    <name>A0A8B7Y7G7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein SPT2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110978454</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089164.1">
        <property type="nucleotide sequence ID" value="XM_022233472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7G7"/>
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    <dbReference type="OMA" id="TPTIYNR"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054552">
        <property type="entry name" value="SPT2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691:SF8">
        <property type="entry name" value="PROTEIN SPT2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22691">
        <property type="entry name" value="YEAST SPT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22878">
        <property type="entry name" value="SPT2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPT2 homolog N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
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        <location>
            <begin position="239"/>
            <end position="254"/>
        </location>
    </feature>
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        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF22878"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022089164.1"/>
        </source>
    </evidence>
    <sequence length="532" mass="59681" checksum="537807CC043B7A94" modified="2022-01-19" version="1">MDFQKLLSIAARNNERAQKEVDERKRYSTVLPPPKKEKRNGVDQAAIRARLERKQQEVQQKASDEQAKKRQLLKLRAESNKKGKKSVEKPKVSGQRESDQRKHGYEDQKHEQKHQSFMKKIQKVAERTRKEGTEPVSKVAPDRPAKPKKPAPVQKGPMSYKQLLALAADQQNGGGSAENKPHTQGGTGADSQPPAEQSEPRNHRQDGMAAKKALATRKLEEARKRESHERRKSGEVKSGSGSNRKPQGTATEGPTSHHHRTNGKVAGKAETPVHLSSTKRPDTVTSKPATSTAKTKHSPAGTGKRYPITTDIRKNGAPNPNCTRQGKQELERKGRPAKLHQSRVEEYFEKKPAANRPRIAPPSRSPPRRQSKLDSFFDRASASTPGSSQGGSSRPQPGLERRVPPVGGQVPRKRPVPSSGPPPSFRAKRGRLLSEEESDYEDDGFIDDTPLEEGGAKDVSKYIKEIFGYDKSKYDYVSDYQLRNMEASFREIQKEEARTTRLGILEDLEDIRREREENRRLKANTATKKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8B3</accession>
    <name>A0A8B7Y8B3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110978264</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110978264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022088797.1">
        <property type="nucleotide sequence ID" value="XM_022233105.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088798.1">
        <property type="nucleotide sequence ID" value="XM_022233106.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088799.1">
        <property type="nucleotide sequence ID" value="XM_022233107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8B3"/>
    <dbReference type="GeneID" id="110978264"/>
    <dbReference type="KEGG" id="aplc:110978264"/>
    <dbReference type="OMA" id="EGIMKEE"/>
    <dbReference type="OrthoDB" id="9970438at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665530" evidence="1">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022088797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022088798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022088799.1"/>
        </source>
    </evidence>
    <sequence length="115" mass="12810" checksum="8859C8E49521B63F" modified="2022-01-19" version="1">MRLSLVVLMAMTLAVTMTCAFDLNPTLLKTVTSVVNSLANEEGQVTVAGRVIKYKAKGRVHSFKEPWVYDGTAWDISSGISEKAKHYKSKQGAIEHAMLKLLERLKRDGIMKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8P9</accession>
    <name>A0A8B7Y8P9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">thiopurine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110978708</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.</text>
            <dbReference type="EC" id="2.1.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.67" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022089604.1">
        <property type="nucleotide sequence ID" value="XM_022233912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8P9"/>
    <dbReference type="GeneID" id="110978708"/>
    <dbReference type="KEGG" id="aplc:110978708"/>
    <dbReference type="OMA" id="PGMRIFV"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008119">
        <property type="term" value="F:thiopurine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000101">
        <property type="entry name" value="Thiopurine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00812">
        <property type="entry name" value="Thiopur_methtran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025835">
        <property type="entry name" value="Thiopurine_S-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10259:SF11">
        <property type="entry name" value="THIOPURINE S-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023956">
        <property type="entry name" value="Thiopurine_S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022089604.1"/>
        </source>
    </evidence>
    <sequence length="226" mass="25998" checksum="EFADB328799DB9FA" modified="2022-01-19" version="1">MAKGLDEEYWRKRWMASDIPFHQTEVHPTLLRYFADLTAGQEKCRFFVPLCGKSKDLKWLADEGHMVVGVELSTLAIEAFFKENQVDFTTSHVEGLSDAELYKSEDDSIQIYKANFFDLNRDILGEFDCAWDRGAFVSLPREDQERYADPLGSVLKPKGRYLLEAVEYDQSKMNGPPFSTPLELIQQLFAVGWSIEPLEVKDGTDDRWRSKGLDVMILRTSLLTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8R2</accession>
    <name>A0A8B7Y8R2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium-coupled monocarboxylate transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110978234</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088745.1">
        <property type="nucleotide sequence ID" value="XM_022233053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8R2"/>
    <dbReference type="GeneID" id="110978234"/>
    <dbReference type="KEGG" id="aplc:110978234"/>
    <dbReference type="OMA" id="HKARISQ"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022088745.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45158" checksum="51A2D03BF40C7EC2" modified="2022-01-19" version="1">MQTPTGERHAFQAADYAVCGSMLLASLAIGFYYGLRGGRQHTSAEYILANRRMTVVPVTLSLLASYFSGISLQGMPSDVYFRGTMGVWAAAPVVFSGFISLYFFVPLYYNMGITSVFEYLELRFNRAVLACGVFAFIFFAILYMGLVTFAVCVAATAVTSVSYSLAVVCLVGVCTVYTVIGGMKAVLWTDTLQMLVIFSTIIIVIIKGNFEMGGIENVWRIAEKGQRIQLLNTSPDPTEYYTVWGLLIGQLGTAATVHISNQYMVQRYLACKSLNVAKTTLSSVLNGVAALLGEHLVKPCWKTLSDERYTLVLKIIATVFALVTFGMAFLVPLMGSVTPAAFASYVVGAAVGVWLGVGNIIHGGPSDAELPLSTEGCDEMNVTTETVVTQYVMNGFVTEYLNSSLATVEPTVERWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9U0</accession>
    <name>A0A8B7Y9U0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional arginine demethylase and lysyl-hydroxylase PSR-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110978548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089322.1">
        <property type="nucleotide sequence ID" value="XM_022233630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9U0"/>
    <dbReference type="GeneID" id="110978548"/>
    <dbReference type="KEGG" id="aplc:110978548"/>
    <dbReference type="OMA" id="HIRECQF"/>
    <dbReference type="OrthoDB" id="10063099at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF19">
        <property type="entry name" value="CUPIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022089322.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="37810" checksum="B58A9B61A9C12E11" modified="2022-01-19" version="1">MSSNGKHGVPKGLNKEKLCQKLTEEITKLKEKSCGRGLSNAEVVDFLTRLRHPRREPAGIGAKVRWLALTVFFPIAVGLLLIYARHEIVAYFVEDPCLIGSNFILSEVGRPLASCELCRNLTAVPVYDTITPAEFVAKHAYNIRPALITGATTTWTAMETFSFNYFKELYTSHPEALQAVEEECQFFPYNTEFTSLEEAFKMSPERAALKEGERNWYFGWSNCDPLVAAELRRHYQRPYFLPDSSESSALDWIFMGGAGRGAGIHLDNVAKPSWQAQLSGRKTWTLIPLPECEDICHTLKVTVNTGDIIVLDTNQWYHTTQIHPGKISITIGSEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YB38</accession>
    <name>A0A8B7YB38_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tyrosine kinase receptor Cad96Ca-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110978802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022089777.1">
        <property type="nucleotide sequence ID" value="XM_022234085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YB38"/>
    <dbReference type="GeneID" id="110978802"/>
    <dbReference type="KEGG" id="aplc:110978802"/>
    <dbReference type="OrthoDB" id="10068185at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF621">
        <property type="entry name" value="TYROSINE KINASE RECEPTOR CAD96CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="168"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022089777.1"/>
        </source>
    </evidence>
    <sequence length="465" mass="49945" checksum="835B0DCCCB3D0D15" modified="2022-01-19" version="1">MAQATAGKGQQQPSGQPQRGQAAGVTVQQVMSGKSGTPGGQAQPVSPRGGGLTAQQAMAGGKAAANPPAGAGGGVTVQQAMGGKQGANPATSPRGAMSMEQAVAGKGAKGGVAQPAAEGGYKTLEQAASKKGQGAVSPRSQNQPTLKREKSEVDEISENFWEVPKESLQLVSTVALGTYGPVWRGKAWDISGRDGMTLVAVKELKQPTSNVAKMAFMKELEVMKSLQKHPYVVNLLGCCTYYDPASMVFEYAPHGSLLDHLRKNRPQSPSGKTPTSGELVTFAMQVAKGMAYLSRQKIVHGDLTTRNILLGQRMVCKVSNAARVRNVVENVAEGRLGIRWMSPESICASVYTTMSDIWSFGILMWEIVTYGSTPYPGMSAREVSNRLKVGYRMERPEHCSPELYSVMQACWDDNPKKRPSFRTLSLDLEKLLTSGKTDHVDASKYDKTKYKDLDDHRPHTPGTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE52</accession>
    <name>A0A8B7YE52_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">F-BAR and double SH3 domains protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110979788</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091534.1">
        <property type="nucleotide sequence ID" value="XM_022235842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE52"/>
    <dbReference type="GeneID" id="110979788"/>
    <dbReference type="KEGG" id="aplc:110979788"/>
    <dbReference type="OrthoDB" id="10065861at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051130">
        <property type="term" value="P:positive regulation of cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11761">
        <property type="entry name" value="SH3_FCHSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11762">
        <property type="entry name" value="SH3_FCHSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000033">
        <property type="entry name" value="FCH and double SH3 domains protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035460">
        <property type="entry name" value="FCHSD_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="13">
        <location>
            <begin position="15"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="495"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="619"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="701"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022091534.1"/>
        </source>
    </evidence>
    <sequence length="805" mass="90520" checksum="EEA894DEBCA30D18" modified="2022-01-19" version="1">MSDKAENLQPPPRKLKLGQELRAVQSEQLSSLHSKFQQESDLLEEIREFSKQRASLERTYAQSLQKLAAQFQQKRVFPTLTEEQKHDEQQHRLALQVWKAILDETEKVSKARLTASETLSSQIAEVIKMQKNTRAQTLKKCDDIFNICQEEIQATVRDLSKAKKNYCETEAVAQEAREKALEAENKLKKGSLKFFQSKTTLEKQMAKLAARRETCDRRSAHMRNDYLLAITSANAHQQRFYCIDLPHVMSTLDGNFYDRLKDYYSIFATTEIELGTYVRACFDKVQGEAELVTREYHSQRFLQKCPVLTTPLQYHYSPLETDQVSSMVIDQKESLYLDREARKWATDVAREAKSIEDNGQVFQDLQSSILQLKGSDTSSDSGFGQEKDSEQKYETLRETLRKSETTKMKAEAKLNMLKNAGINVDQWLDSAYEAIAKEAEIEAQMKAQQAAAQARSQSDGLNASRAMNSFDSFDDTFEATLNEDPTPAQPSSVQEASIRATALYNYQAQRDDELTIRGHEYLEIIEESEGDGWVKAKNDSGQSGYIPESYVQVERRHVARQLSNSSEGSPGWSHLSKMGQPYSSSASLTDYEVQAAMANQAMSASGQTVGECESEQADGPVCFARALYDYQGCSQEELSFSEGCVIKVLKQDDEGDGFWEGELNGRVGVFPSLLVEELGCPSVNEVVTPETPTVFVFPEEIEESDEPPSTLPPSLPPPPLPDNLPTLSIYSEVDRRRPASADIPESPNACPFYTRSAPQSPTMPGLKPARAAPPPPGKIKKKLCEHREHRKPETRYSDEGPITMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEI7</accession>
    <name>A0A8B7YEI7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain-containing protein R3HCC1L-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091664.1">
        <property type="nucleotide sequence ID" value="XM_022235972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEI7"/>
    <dbReference type="GeneID" id="110979853"/>
    <dbReference type="KEGG" id="aplc:110979853"/>
    <dbReference type="OMA" id="GNSHDSC"/>
    <dbReference type="OrthoDB" id="5418203at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039884">
        <property type="entry name" value="R3HC1/R3HCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678:SF0">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21678">
        <property type="entry name" value="GROWTH INHIBITION AND DIFFERENTIATION RELATED PROTEIN 88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091664.1"/>
        </source>
    </evidence>
    <sequence length="651" mass="70894" checksum="2ED268E36E6D548E" modified="2022-01-19" version="1">MQSFQDDVSSEGGTPQAQSKETSRKSKRASQELYVPRGRRQQPLAGESTACQVELAVDKPGGAQTSTRQQGRKTEKKRTRDGGKGKQPRDRKTSTDGEEVENSVAKEKKAHARGKQGRRGDQQRYVPRPQREDAKAQKSCSGEGVTLPAEDGHNSSSLKPAGQSEGLQVSRAGVKGVKQSAKPLNVSPVPEDWNEIDYDDREVTYQPTGTRLTAHGQLVPVDPSALPQAVQTETEGETLATETDQSQGALGCQEPEVDPDAKAMLESSVAGDAVSEEDNGKTRDSNSELPVAGIAVETEDATKMPDGSACRKSNSSEDVAVGADEIIKTSEDVMGDEKSPVTMATNKEVSQGLDIDARVSTNTDAVGSLSLNHEIDSEEVRLSPKDEEQPEASPKLGAASSDLLARDDADIPYVSDELNDAAGCEQEEVVSAEIALKVEEPGDDAGNDDGDDWDAMFDESGDCLKQEEIQELSECVGNVPVSVKHSKRDYYNYQPKDNLNYGELEHIIEVYDFPVDFKTHDLITGFCNMKTKEMDIKWIDDTHALAIFPSSIIAQDALSISNPMFRTRSLVLASREAKLKAKHCLEFLIPPTKPRPETSAATARRLVSGALGLKANISKEQRAAERQKIKEAKDRRRNEKKLQEDIWSGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFF7</accession>
    <name>A0A8B7YFF7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Uncharacterized protein LOC110979639</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC110979639</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091330.1">
        <property type="nucleotide sequence ID" value="XM_022235638.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091331.1">
        <property type="nucleotide sequence ID" value="XM_022235639.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022091332.1">
        <property type="nucleotide sequence ID" value="XM_022235640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979639"/>
    <dbReference type="KEGG" id="aplc:110979639"/>
    <dbReference type="OMA" id="TIVYHHT"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007397">
        <property type="entry name" value="F-box-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF17">
        <property type="entry name" value="FBA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04300">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01198">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51114">
        <property type="entry name" value="FBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="FBA" evidence="4">
        <location>
            <begin position="703"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="1745"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="938"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1112"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1134"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022091330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022091331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022091332.1"/>
        </source>
    </evidence>
    <sequence length="1969" mass="221544" checksum="C72150027CB58BD0" modified="2022-01-19" version="1">MGTKVSKQQGLKASKKVAVVTAFNVVKNQAAVKRIAALKLTQAMPKELQKVDLGLPPPKDIKTVADFACMTGTASSGFPIPAFTKTYFSVNAKHGGGTALMLLTDVTTSTFTSELCLIRCGFGGNHFQYTSLSKAGEHSLYKYFRVHTDADGFMSPCLRFGFSRATIVSNLAQMGHCGVFVVYSGPKAKGFSSTATLKTDISVSPGKYGSALLVLCSAAGKKGSQPCNAYFVAFSHEPGKLVAHAITDKNCDDLWSFSCDQGMLEITGPSQSHYGIWRSDDNGDTKPSGKVVHTQTFNGSEKTVLLESLSGYVDYSLLVLCSCSRGVDDMTSSALYLVTVQKWGVRCSFIGGSSRSSERASDWFISEDDNQLVVVGPSAPCRYSFMSNLPEDVTDPQQRCFQNSCLATGFESKYRGGVYINGASITGWVSQMSQVKIMLNGRMIELVEAGQLLEQPDGRLGFQRELSSDENSTGLKLLQVYGMTSDINNQPVSVELEGSPYRIVNQPQGVLYAVNLGGPMYQALNMVVFSGTEVTFKVDNEADGVKCQRKFNCLIDANHNLYNMMTNTNDGFLFSTHNGTHPEFADEMSYDIPVNKSGNLTMKLYSVSNYLKRQIIKINHESYSSEVTQQLNEIPEVVPKYTAKIVSIPFESNGNNINLFFRNSPGHGGCHPAAFMVHDDTYREATPTKEEEAEEMSMKQKLADTLVPLDRTLNLKQMKIAGWSSNLLINPSGETGDLSNWNYSGNWKVSEGGDQTETMFISSHMWCTKYQEVELTEHFSEKHLDSSPEIQVSESFREGCNKGGFYSMTATLMGHDGSVIKRQTTGQQGSIKTSDWIRVCFTFKNYGRGVRSVGIESAAKDDKFWAGHFGAYCSAASIRVKSEVGAASGDNYSDIQPSTGPSFTKELDLMVRGLYEQHQEELTDMQRLMEEMEDRLGTEMDASRQQSGQARSRPVRPSNKTKRKKREIRIFVSSTFKDFKEEREVLIKKAFRELNRICLDRGVFFTYVDLRWGITESQTADGETISICLREIEKCRPYFVCLMGDRYGWSQTQHKPDKLLNKSFNYAIENFKPLEWIEQYRYETSVTKLEIMHAALNDTEANEGRTFFYLREPRISRDDLPPPDDEEEEEEEKKEEAAAGEKSENEKGDTDNDADKKDESTEDEKKKSKKKQETQWHFDRQQQLRQTVESSGMPLRRFSAANEGCELIKKDLVWCVDQDFPPGSELSALQREQEAHQAFAEPRLRIYIGGQEYIQQINAYVQKATRSGEDFVNTPFVILGESGSGKSALVANWTRQFEEENPGIFLFMHFIGSSAESASHLNLLRRLYEEIKQFFGFEMTVPSSQRNLVLELSTWLQMAGKQARVVLVLDALNQLDSGSGAGEEQDLTWIPKELPKNVVMIASTLPGRAMDAVTAAGWPTMRVHPLNINEKLDIVTGYLNLYGKTLNEEQRSLIIDAKQTDNPLYLKSLLDEVRMYGNFFQLTTAIREYLAAGNPGELFVKILDRFEDDFERGIVERPGLVRDATTALWCSHRGLSEQELLQFLQVPSKVWSPFYLSLEENLVNRNGILNFFHDHLRQAVERKYLSTPELKRKAFLALADWFNSQDIDDRYVEEVPHLLAHAKEFKRLQATILNVAVFERLMSTEEGKFQLIKSWQLLGGYEEVEQSYLGVLARSEEWEKSRLKDGLIRAMAGFFTQLGLLKGARLLNERLLSELEARYIGSHATIVYHHTKYEYKTRCNHPDVLDVLISLGTVSIKLGDHNEARKHFHEALERQNMIKTPEQKLQLVKALLGMGSVLILQLKADEAIRFLRRAEELATDVLGPKHHYVAAINGQIGQLYYSQSKLDNAMLLHLWDLKLTQSDVGLNHPRVAAILNNCGLVLDDMNDKMAGEVFQAVLGILIEAYGKDHVDVATVRYNLGLYFLATNMYQRAKYQFDEALRVCELFLEGDHPTIRATKTAMAKLKDFMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGU7</accession>
    <name>A0A8B7YGU7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110979827</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091620.1">
        <property type="nucleotide sequence ID" value="XM_022235928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGU7"/>
    <dbReference type="GeneID" id="110979827"/>
    <dbReference type="KEGG" id="aplc:110979827"/>
    <dbReference type="OMA" id="HAVLITE"/>
    <dbReference type="OrthoDB" id="10641033at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091620.1"/>
        </source>
    </evidence>
    <sequence length="1006" mass="111339" checksum="19C6B2D820A0C29A" modified="2022-01-19" version="1">MNKEGKVQGNRAESHLQGTDDAQHTYECSEADTETKRKEIKLNTGACCHTTNFAFNTLLLLQAAASLKQRDTAPGKTSNQCSLPRPVEKWLSNSEEERRQKLLGSSTEVAATVKSLAGDNPVPLEWSEVNLKTKQFQVTALSDSEQPSKIAKDVPSDPEITDVQGAPRPRTTVLPGRAITNSRSHNRVLVWNEKEKAYSSATTVAESCARTSPCIKTSKETLRQWTCRQSSLELSPVHQRTNLLALQTENGSVPRTNNSSPDMNQMTIRPSPGAAPSQSSSPQQRSSFSNFISASYANVKISPKSSSMSSSRPTCTPVFRHALDRKMGCPSLGDGNFQDGKFKTVALVDSVTNIASKQSPSLPCRKTVIVISPKGAASNMHNTSSSPTNPVMSPAAVNPERVRDHTVLMKSGVMKPGEQETRVLLHSQKRGGVAQFTPSPVTANTQSPSNGKLCPSPGSTFKSRGPGSQPTNLGPGLSNLNSPCVFWPSGGRIYTLVPVKILTKSRQSPVKQTLPRSFESGMNPTLCMMMKHFNYTMKNCDRLIDNHFLKKILSSDVRDIDDLFDDVELRERMQQHFVPDWLLQFIIESDAREKMGNQWKERVPSGKVDGDTSGKRNETTGSPKQYCMQQAGKMARATSAEGASVTQDVDDAAVLRHHAEDNRHAGACVCSDKSPDEVPNHNRNACSHVDKAPDERSSNLDESKRWNRDFSCGTSGVTGVNPLKTLSSRNQSPALPCQEQRNFQLSNSTLNNLGFLDLMPDRALWNLLFHLFPPWKKTCLGIDGNDVEEFFRRHVDLCTSHRKSTVTKRQRYKSGQHQSTAACPKTEVRDGEVDKRKRHKEKKTSVDRESSQCSEEALDARKRSKSKSKSANSRKGTPKKKHTHGDSYRKGTSPAQMELHAREKKKKHHKRKVNGEMKGPILEKKWHSSTEFPSEVRTSLKKKLSSSSSDDALGNKGRGQLEKTPEDRCKSTAEVPTCSKALPPKWNLKLILKTPRSKAKRSKKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YH81</accession>
    <name>A0A8B7YH81_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA cross-link repair 1A protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SNM1 homolog A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110979906</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091755.1">
        <property type="nucleotide sequence ID" value="XM_022236063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YH81"/>
    <dbReference type="GeneID" id="110979906"/>
    <dbReference type="KEGG" id="aplc:110979906"/>
    <dbReference type="OMA" id="NSSILNW"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000001">
        <property type="entry name" value="DNA cross-link repair 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000010">
        <property type="entry name" value="DNA cross-link repair 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="9">
        <location>
            <begin position="816"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="585"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="744"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="614"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="689"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="744"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="806"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022091755.1"/>
        </source>
    </evidence>
    <sequence length="1179" mass="130958" checksum="294CCD61D0DFC456" modified="2022-01-19" version="1">MTYMMAESDDDIWEYKSLKRTKRSDVCSSQPSSRQPPSKKLRISNVSSQIQSNEHGRTCRNTNIRARGNVRSCPLILKSEEETSNLELLTQSNKLQSLKIPKKPMSQIKLESFSPAAPSRTTKPAKDHHYEDRQMSSKTPKNKSRCTAAVNKRAKQPTKSSCKILKEAENRKKKSTCCVKSVKMEVNDNNTDRNRRILQGYCPFCQMPFGALVLDSPERHVAECLSKPLQAENECPHGIACDVTIESHYRKFRHCLLAEARATLPNEARSKMCEQQELKTQHQKGMTQKNEQQEPLSSSRKMSDPSSHDAISSLAKSLQNSTAVRQHPVTKGEKYATEGMSNATGNTSSNVVSSQIGSLNSIQKSKSMEKAVQFGLKAAAEESKLVSLEQGSEPQKNDGTDQVHCISSDEDIFAYSEHSCETLSVASQEDTQKGCEQPVDDNDDTQSSAMSELSTSIFADAGPVEPQQLTAVLTSCCTQTASNSYTHCTESSESTSCIQAKDLLPSTCQTKTSNFPLRVASKGNRQAQNLNLDFDHCSQVDISIKVTPCEKADHTKQSSDNLCTTPSFFKMKAKKAHRIQVMVEENQDNESANSDADDSSVSDSAVPSVLKTNIKHEAEDQEKWSHGCLTNKNERGGESNVDSHHFMQNGVASEVQGSSISAHSTTTVGKECSSDNEPLTKQESVASQDQKRYSKKVAETSKEGTLSQLVRPVISALSSAVPSNSLRQSSLASYFGLGAVKKENLSQEGKQERSLHATETATASNAMPMNSDPMTQSSHRSYKSHSRSRNGRWSKSSSQYDDDTGHPQSQRAGSSQRLCPFYKKIQGTSFVVDAFRYGDIPGCTAYFLSHFHYDHYGGLTKHFKHLIYCSQITANLVRARIRVEAKYLRPLPMNEACVISGVEVTLLEANHCPGAVLFLFHLSDGRVFLHTGDFRADSAMEQLPQLRSCHIDQLFLDTTYLDPQYDFPTQAEVIEYTAQIAVDVVKRNNKTLLVCGTYTIGKEKIFIAIAEAVGCKVFVAKDKKNILDCLENSRLQSMLTLDKNATRLHVVTMATLTNQSLKEYLSKFSGRYDAVVAFKPTGWTHSDKKTNLQDIKPSRSGPVSIYGVPYSEHSSYSELRRFVQFIRPNRIIPTVNVGSAASRNAMNEHFKTWLSEEIGSSQGRQLHQPRNSSILNWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YID3</accession>
    <name>A0A8B7YID3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 10">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110980116</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 10">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9 10">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 10"/>
    <dbReference type="RefSeq" id="XP_022092160.1">
        <property type="nucleotide sequence ID" value="XM_022236468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YID3"/>
    <dbReference type="GeneID" id="110980116"/>
    <dbReference type="KEGG" id="aplc:110980116"/>
    <dbReference type="CTD" id="191"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000007">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9 10" id="KW-0520">NAD</keyword>
    <keyword evidence="4 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="12">
        <location>
            <begin position="195"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="226"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="303"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022092160.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="48113" checksum="22D26C17FAA9EE21" modified="2022-01-19" version="1">MAANGGKLPYKVADISLAGFGRKEIVLAEHEMPGLMEMRRKYGPTKPLKGARIAGCLHMTIQTAVLIETLQELGAEVQWSSCNIFSTQDHAAAAMAKSGVPVYAWKGETDEEYVWCIEQTLVFPDGQPLNMILDDGGDLTNLVHEKYPQFLADIKGLSEETTTGVHNLYKMMKEGKLKVPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDIMLAGKVCVVAGYGDVGKGSAQSLRAFGARVLITEIDPIIALQAAMEGYEVTTMEDACARANIFVTATGCANIITKEHFLKMKENAIICNIGHFDCELDLKWLEDNATKENIKPQVDRFTLSNGHHLIVLAEGRLVNLGCAMGHPSFVMSNSFTNQVLAQIELWAKTDQYPLGVYMLPKKLDEEVARLHLDHLDVKLTKLSPKQSEYLSMPVDGPYKPDFYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJT6</accession>
    <name>A0A8B7YJT6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 14">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="primary">LOC110980811</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Chromosome</location>
            <location evidence="14">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 14"/>
    <dbReference type="RefSeq" id="XP_022093508.1">
        <property type="nucleotide sequence ID" value="XM_022237816.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022093509.1">
        <property type="nucleotide sequence ID" value="XM_022237817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJT6"/>
    <dbReference type="GeneID" id="110980811"/>
    <dbReference type="KEGG" id="aplc:110980811"/>
    <dbReference type="CTD" id="7015"/>
    <dbReference type="OMA" id="AYMIQRY"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049139">
        <property type="entry name" value="TERT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21399">
        <property type="entry name" value="TERT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 14" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="15">
        <location>
            <begin position="442"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022093508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022093509.1"/>
        </source>
    </evidence>
    <sequence length="948" mass="107114" checksum="D821A7C6FAA152AD" modified="2022-01-19" version="1">MEVLKKVYPRTFTLSEYLEAVGCPGLIQPQDKVGFRTFVQTTVLTEHDGALQLGLQTDFRHCSHQVEVVAKAVQILRSRGVAMTKNVLLFGKVQTKEWGIPESNNQALVKMPFWEILLARVGDEVMLHLLVNLSVFLFAPPSCYIQVCGVPIYDLVSRPSKALHHPASMKTGPDVASKSFTMISVCHCKKGCSTLPKSHPLECLPASNSGARKLLSSVMPAQTALKPAKQGRTKILRTRRRFIPMQMLLKEILVAHKKTNITALLDAHCPTQRQGVASEGSPTLQDLLNNTMEPWRVFLFLRGVLLRAIPFPVWGSMHNRRAFFKFVERFTKLGKSEKLDSEQLTKKINGVDCEWTQLKKLRGRSPCHSDVMMQRRMVSSLLSWIMSDYVMALLKMAFYVTETSASRNGVVYYRKSTWNMLEKIGLEQCKASGNLKPITDKLAESFVASGASFGCSSLRFVPKASSLRPITNMKQAARAGKQSVSINTLLEDVYSILTFHRSGQPSCLGSSLFSINEAYQKWKQFVLEYRKQESRPLYFVKVDISQCYDSIPHIALLSVITELLKLKSKNQLFTIHRYVAVTQGGGTPRRAFRRHAHLEEGRHLTFHQMLLAQAREEQWKSAVLVNRVWSHSTSAEQVMASLKKHVGCDIVKFGGRHFLRQKGIPQGSTVSSLLCNFFYAAMETRCLPPMTQDELMMRLLDDFLLVTPNLEKAESFLRVLLNGLPEYGCQTNPTKTLTNFPFVFDGRQVQSVGPSDMFPWCGLLFNTKTLEVCNDFTRYKDVSIRYTLTVDSSGAVISKVKAKLLQALQAKCVGFFLDPEVNIHPTIRRNCYELLLMSAFRFHSLLRVLPHNCKTGTSAPRRLLGVLFRLTDKLHRLGCPLRKSETKWLCLTAFQTKLQLHQGSYRRLLKLITKTQRKVSKHVPQADMIALVTACTPALPQAFKAMRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJW9</accession>
    <name>A0A8B7YJW9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110980841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093544.1">
        <property type="nucleotide sequence ID" value="XM_022237852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJW9"/>
    <dbReference type="GeneID" id="110980841"/>
    <dbReference type="KEGG" id="aplc:110980841"/>
    <dbReference type="CTD" id="51605"/>
    <dbReference type="OMA" id="TRCRPYQ"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038170">
        <property type="entry name" value="tRNA_m1A_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="260"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022093544.1"/>
        </source>
    </evidence>
    <sequence length="484" mass="54880" checksum="EB4D20408B027A70" modified="2022-01-19" version="1">MASSDVIKQGQNVILKKGKSLRLYQVWRKRKVHLDKKHFYLDEAIGKPYGTTWDVCGHNVQLVSQDDEEEETREGGTDNRTLIDDKCSQKLSYEDIQALKNTGKHGEAIVEQLVENSSSFKEKTIYSQAKYVKRKRDKHLMRFQIFRPNTMLLCEMYSSRAPSKNIHLRIDTLAQILTAANIQSGINVIMMETCQGLLLGAVMERMAGKGTIVQIHSEHVPVRLAVEAYNFPPDYKDTLYGFPLDQISLLDIQEPVDSNCPQRNTCDEESHRPQAPKNEEHCDHSAESSGALGTAKESITSRASQRDEGHKPQEREEERSSSEEDDSSNVGDCGAAPDDPVAVETDCKSGETATQGQKRKFPVNPEKEARKQRRRENLNRVRDLLHNTKMDALVMACRFQPLPIFTALFKFLAPSRPFVIYCHYIEPLMECSEWLRNSNDAVNIRVTETWLREYQVLPERTHPSVNMSGTGGYLLTGTTVSNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YL59</accession>
    <name>A0A8B7YL59_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Filaggrin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110980739</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093372.1">
        <property type="nucleotide sequence ID" value="XM_022237680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YL59"/>
    <dbReference type="GeneID" id="110980739"/>
    <dbReference type="KEGG" id="aplc:110980739"/>
    <dbReference type="OMA" id="SIGMEGC"/>
    <dbReference type="OrthoDB" id="10053436at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007167">
        <property type="term" value="P:enzyme-linked receptor protein signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF5">
        <property type="entry name" value="CRK-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="922"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="470"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <begin position="562"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="737"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="801"/>
            <end position="918"/>
        </location>
    </feature>
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        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
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        <location>
            <begin position="409"/>
            <end position="421"/>
        </location>
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        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
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        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
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        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
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        <location>
            <begin position="589"/>
            <end position="649"/>
        </location>
    </feature>
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        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
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        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
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        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
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        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022093372.1"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112146" checksum="135AD77E6BCD9625" modified="2022-01-19" version="1">MMSTVTSRQASFSENLDTKWLAQQTGKENILLIRKTSKYVHLRRQQSKSLIIPADKYRLNYVEVEIGPPKRRDGSDKSPVVKVSNGNSSRVNYSTIIFPNKNASPTSTSASQDKADSGGTRSKVPEIPPHHSSTAPTFTFASQTSKESSHQATRVSTSVPGGPVGGGGRKRAGHGTHAKLERKGSQLSEAQLQHQQQQQQQLETPKTPPNSPPRRRALSTPTRSRKFPSDPEIVETIKAQQETEPAPPKTRTLPPREKPWSPDTAEQGYQEEEAELVSSRTRVDLQKAQASSLDSGMLSSSAPSCQLTHAMQAIRMKARRKSSSGDGYEVVNDPAMVARMAALCTQEQQFNVSSGAGGAAVEPPPLSPEAANILRSSPVMKRHRTELEKAFARRKLTGRISGEPDGYASHSGSHSSSGDSSPQEGMPSQLSDVSSVGTKFIPVLPIIKSSRERGSPDGQKTASGEYRYMDGSQQQARKPIPAPRFGQQSRESSSESINDPLYLNQRPMPSPPSHQQASLDSTTATQQVGDDTYMNVAFCKAKQDNSHRYENVFLDDRTVSLDRCSNASDSPRDSLEIHSSRPIPAPRTHSSNNVHAASSSVAAEYSNQQHQGSQHHQGTQLHQGQGNQHHQGSQHHQGNQHHQGSQHHQGNQHHHGNQHHQGNQHHQGQGHQHHQASHHHQGQGNQHNQASHHTHPGNQAKVSSQYQQGKQHGHTRQGSFGSTAAILSHIGAATTPVCPGGSASPNIKSKQGSSASAHQQLNDSSEALYATPCKHGHLHHSSGLSISNHHGLAPLKVAHGIAPEVPSSPKPEIPSHASSPRRDSHGSTGSLGGKVAEAEKSSSISKALGHLIKDGEKRERKHRERHTGEKKSREERKAHAEKKGHHGDREKRGHGKRHRGDSNGSASSKSKPERPSYGNQPWYYGRMLRQECEFLMLSQGQSCQYLVRDSSHRTGDLMLSVLYGSKVHHYVIQTTPNHKFHIAHHDFNMVEDILEFYHHHVIMYSPQKEPVYLTEPFILKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMD4</accession>
    <name>A0A8B7YMD4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="5">1.3.1.124</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2,4-dienoyl-CoA reductase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110980338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + NADPH + H(+) = (3E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77559"/>
            <dbReference type="ChEBI" id="CHEBI:84791"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer, dimer and oligomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022092631.1">
        <property type="nucleotide sequence ID" value="XM_022236939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMD4"/>
    <dbReference type="GeneID" id="110980338"/>
    <dbReference type="KEGG" id="aplc:110980338"/>
    <dbReference type="OMA" id="MEWGPAG"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022092631.1"/>
        </source>
    </evidence>
    <sequence length="280" mass="30257" checksum="74194BC72B117896" modified="2022-01-19" version="1">MADSTLDACLTSYDYVFKPDILRGKVAFITGGGSGICFTVAEVFMRHQCDTVIASRNLNRLKEAAKRLETATGQRCLPLQVDVRKPEEVLRSVDQALSHYGRIDVLINGAAGNFPLPASKISFNGFKTVLDIDVMGSFNISKAVYDKYMKDHGGVIINISATLPYRGRLLQIHVNAAKAAIDSMTMTLCNEWGPQGIRVVGIAPGPIGDTEAGAGMLGEEVLKKIPLQRIGTKREVGDCAVFAASPAASYISGSTIVMDGGHWMTYENDFGFYTKPKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNT8</accession>
    <name>A0A8B7YNT8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18">LIM/homeobox protein Awh-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110981582</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094929.1">
        <property type="nucleotide sequence ID" value="XM_022239237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNT8"/>
    <dbReference type="GeneID" id="110981582"/>
    <dbReference type="KEGG" id="aplc:110981582"/>
    <dbReference type="OMA" id="CYTREAD"/>
    <dbReference type="OrthoDB" id="10068367at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000023">
        <property type="entry name" value="LIM homeobox 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000027">
        <property type="entry name" value="LIM/homeobox protein Lhx9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050453">
        <property type="entry name" value="LIM_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208">
        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24208:SF127">
        <property type="entry name" value="LIM_HOMEOBOX PROTEIN AWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="32"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="15">
        <location>
            <begin position="94"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="16">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022094929.1"/>
        </source>
    </evidence>
    <sequence length="285" mass="31784" checksum="82F4EB16A23706F8" modified="2022-01-19" version="1">MPQIVRQMATLPHPADIIIKEEALDSAISKCVRCNGCSEIIADRYFLRVGGSLSWHLNCLTCTACLTKLDTQVTCYCRDSKVYCKHCYSRTFSAKCAGCGRTIQSSDWVRRAKNHVYHLACFACDDCKRQLSTGEEFAMLDSKVLCKAHYLDMIEGSFQAATGKNDSSSVLGSDGVDKRNVHKSKRIRTTFSEEQLEVLQANFTIDSNPDGQDLERIAQQTGLSKRVTQVWFQNSRARQKKHKGSPRDMLHGSSSGDEASRQDMCVTCGTTYCVCLKERGPSCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQW0</accession>
    <name>A0A8B7YQW0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110981925</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095663.1">
        <property type="nucleotide sequence ID" value="XM_022239971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQW0"/>
    <dbReference type="GeneID" id="110981925"/>
    <dbReference type="KEGG" id="aplc:110981925"/>
    <dbReference type="OMA" id="EEENIRC"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022095663.1"/>
        </source>
    </evidence>
    <sequence length="314" mass="35724" checksum="807B88B993B66DA4" modified="2022-01-19" version="1">MLVGATGVGKSTLINTMINYILGVKWEDDFRFKIVDKRVEGPQSQAHSQTQVIAAYTIHSNEHHTIPYTLTIIDTPGFGDTRGIERDKAIVHQVKEFFSHPEDHHVDHLDGVGFVANSTTGRLTPTQKYIFWSILSLYGKDIEPNIIILATFSDRGRPQVVSAFEEENIRCEGNLFKFNNSALFECNVAKGGSDSGEDDLAVPHAYWKMGMRNMKSFFKSLDQLEPVSLVLTKEVLCERLRLENTSENMHQQIQTINTKCFVDMNVEACRCTQRLQEIALKPQMSMKEYVDILIENEKRSHVLGWEDRLSVKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRE8</accession>
    <name>A0A8B7YRE8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="10">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110982034</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022095858.1">
        <property type="nucleotide sequence ID" value="XM_022240166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRE8"/>
    <dbReference type="GeneID" id="110982034"/>
    <dbReference type="KEGG" id="aplc:110982034"/>
    <dbReference type="CTD" id="7486"/>
    <dbReference type="OMA" id="VGLTHEI"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000005">
        <property type="entry name" value="Werner syndrome ATP-dependent helicase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000941">
        <property type="entry name" value="Werner syndrome RecQ like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029491">
        <property type="entry name" value="Helicase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14493">
        <property type="entry name" value="HTH_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="211"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="403"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="12">
        <location>
            <begin position="780"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1031"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1051"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022095858.1"/>
        </source>
    </evidence>
    <sequence length="1100" mass="122838" checksum="1C4F30FF780A18E0" modified="2022-01-19" version="1">MNQLEALKCLAQDVQAMLRYSTFCHLKTIQSGQWLLAQAMSLLTKFQMLAEEDVQHSHDEMTTRDRSGWNDPEESPLDAALEEDEDVLEPTPVKIKPEPKTLAFSKVCQEQKQTLSEKEKQETEEMMDFLQNFEEGTDFDQDVLEEIDVSSRQASGDLVKDAEEETVSDDGEDTDTGEYDPSLSPPDQRHTDVLKTNFGHAKFRPMQWKIIHSVLARRDQCVIMATGYGKSLCYQFPAVFTGGTSLVISPLISLMEDQVLALRIANIKACFLGSAQTEMGKVRQEILSGVYRVVYLTPEFASVAGDILKDLQQRVGITLVAIDEAHCVSQWGHDFRSCYRALGKLRTVLSEVPFMALTATATPPVCKDICTTLRLKNPLVTCTSFDRPNLYLEVRLKSGIRSDLQSLMVETHKFYYEFDGPTIVYCPTKKATEQVGAVLKDMGVKACIYHAGLTPQKRKDAHHKFVRDELQCIVATVAFGMGIDKPDVRNIIHYGAPKDIESYYQEIGRAGRDSMASNCYVFYSRGDFATSRYLLKDITNEKFRAHKLCMISKMEQYLSTTKCRRQEILSHFERKGTSKSTVMNTDQCCDNCKCRLSSVGATLGGMAEKDYSKELLHLLTAIEATGARFGIAVPVLFLRGSVNQRLPAQCQSHGSFGCGKYRPEKWWKSFARQVISEGFLVERQVIGGFGPTVELSPKGLCWYKETMKGNNKSFKISPSQEMLSFEKTVQKPAILPQSIKSRTLPSTQFINWQQVSFDDDEAKAGPSVQAAQPKMDPKEQQLQGVLYSKLMNLRNSLASEIGAAPYMVANNKNLHDLAIIRPSTKQSLLKIDGIAEARADKFGLRFIEAVREFCKENNLKTDNFPSHISDSQDTHSEVFQKTSIIHHISETVQESYSLFHEKNMSLADIAKERNIKESTVGGHLADAIRAGYPVNFSRLNITSALQKQIEGVIRAPPINSDISQLAPIKALLPGSVDWYQLKVVVAILQTQHGIPTCKSVSDNMDKTAKPVPCRQLSGSSRLVGPQLMTYKSPLHKPPLSVTTIPDPPSSSPQMSNSSPSLEQDGTKRKLPSWFEGSAKKGKICEGNSKKTKGSSLFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRX9</accession>
    <name>A0A8B7YRX9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Intraflagellar transport protein 122 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110982134</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096034.1">
        <property type="nucleotide sequence ID" value="XM_022240342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRX9"/>
    <dbReference type="GeneID" id="110982134"/>
    <dbReference type="KEGG" id="aplc:110982134"/>
    <dbReference type="OMA" id="GDSFDTW"/>
    <dbReference type="OrthoDB" id="10255582at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000003">
        <property type="entry name" value="intraflagellar transport protein 122 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000005">
        <property type="entry name" value="Intraflagellar transport protein 122 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056153">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056152">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039857">
        <property type="entry name" value="Ift122/121"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057411">
        <property type="entry name" value="TPR_IFT122"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056838">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764:SF4">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 122 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12764">
        <property type="entry name" value="WD REPEAT DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23381">
        <property type="entry name" value="Beta-prop_IFT122_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23377">
        <property type="entry name" value="Beta-prop_IFT122_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25295">
        <property type="entry name" value="TPR_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25144">
        <property type="entry name" value="Zn_ribbon_IFT122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25143">
        <property type="entry name" value="Zn_ribbon_IFT122_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="13">
        <location>
            <begin position="13"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 first beta-propeller" evidence="13">
        <location>
            <begin position="226"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 second beta-propeller" evidence="12">
        <location>
            <begin position="335"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Intraflagellar transport protein 122 homolog TPR" evidence="15">
        <location>
            <begin position="596"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="IFT122 zinc ribbon" evidence="14">
        <location>
            <begin position="1031"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022096034.1"/>
        </source>
    </evidence>
    <sequence length="1222" mass="139789" checksum="C40531EB8E39695F" modified="2022-01-19" version="1">MRAVPTWVDKVHDRDKIEQCIYDIAFRPDGSQLIVAAGNRVLVYDANDGALIQPLKGHKDTVYCVAYAKDGKRFSSGSADKSVIIWTSKLEGILKYTHNDAIQCLSFNPITHQLASCACSDFGLWSMEQKSVSKHRTGSRITCCSWTNDGQYLALGMYNGCISIRSKNGDEKVKIERPGGGLSPIWSIQWNPSRPKSIWNKSEESCLSSSSNESIKKSNYLYSRRREETQDILAVVDWGQKMSFYHLSGKQTGKEKNLGFDPCCLSYFPRGEYMVIGGANKQAALYTKDGVQLGVIGEQSSWVWCCEVRPDQNYVAVGCQDGTIAFYQLVFSTVHGLYRDRYAYRENMTDVIIQHLITDQKVRIKCRDIVKKIAIYKHRLAVQLSDKIVVYELYSDDASDMHYRVKEKVNKKFDCNLLVVCSQNLILCQEKRLISLSFKGVKEREWVMEALIRYIKVIGGPSGREGLLVGLKNGQILKLFADNPFPIVILKQQTSVRCLDISCSRIKLAVVDEHNTCLVYDVNTKELLFQEPNANSVAWNTQYEDMLCFSGNGMLNIKASNFPVHQQKLQGFVVGFAGSKIFCLHVYAMTTVEVPQSAPMYQYLERKQFKDAYRVACLGVTNKDWTALAHEAMEGLDFDTAKKAFIRVRDIRYLELIHSIEERKRRGEVNDQLFLADVFAYQGKFAEAAKLYKRAGQEQRAMNMYTDLRMFDHAKEFIGSGDPQDKKLLITKQADWAKNINEPRAAAEMYLSAGEHLKAIEIIGDHNWADMLIDVARKLDKAEREPLSRCAYFFKKMEQYAYASETFTKMGDTKALVLLHVETRHWDAAFTLVEKHPEFKDDVFVPYAQWLAENDRFEEAQRAFHKAGRQDEAVKVLEQLTHNAVLESRFNDAGYYFWMLSMQCLEIAGAEDSKQEDMLAKFHEFQSKAEMYYVYHSIQRYTDEPFTSHLPDALFNMARYLWHAIIKDIPHGISKVNTLYALAKQSRSLAAYKLARFAFEKLQSLRIPLRFQESIDLGSITIRSKPFHDAEDILPMCYRCSTTNPLLNNQGNQCINCAQPFVHSFSSFDILPLVEFVLEEGITDEEAVSLIQMEPMRKSGQRGDGWQESTVGGAQSMRLDEYSNEGAEEDPFTARLLSFEQGGSEFVPVVVGRSVLQSMERHHVIIRKWPSPLRYQYFKTIMPDVSVTICPSCNQFFHTDEFELLVLQKNHCPFCRKSPNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YS46</accession>
    <name>A0A8B7YS46_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110982163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096104.1">
        <property type="nucleotide sequence ID" value="XM_022240412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YS46"/>
    <dbReference type="GeneID" id="110982163"/>
    <dbReference type="KEGG" id="aplc:110982163"/>
    <dbReference type="OMA" id="NDIFQCK"/>
    <dbReference type="OrthoDB" id="10031931at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00045">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DED" evidence="3">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="2">
        <location>
            <begin position="151"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022096104.1"/>
        </source>
    </evidence>
    <sequence length="218" mass="24848" checksum="8FE5B03A60F49FCA" modified="2022-01-19" version="1">MSYLQPPPAQHTKLLDKISRALTDEDVPRFKNRCLAEGIRPGELERKSVLELLQLLDRRRVIAPGKYDHLVLLLTDIDRGDLVQDFFTPEGEQETCVVSAPAPCNRGTDDHHHPQHRPPSASMNSVISDKGLSWLASKMGSDWEQVGMQCFGMSKNDIFQCKADNPHSVQNQIFSMLHKWKCRSGYKATYAQLLNMLAEFPDFDKTILEEMHEKIPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSC1</accession>
    <name>A0A8B7YSC1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: uncharacterized protein LOC110981785</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095365.1">
        <property type="nucleotide sequence ID" value="XM_022239673.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110981785"/>
    <dbReference type="KEGG" id="aplc:110981785"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042653">
        <property type="entry name" value="Leng9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46729:SF1">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022095365.1"/>
        </source>
    </evidence>
    <sequence length="217" mass="24777" checksum="4756FD82D8E5A4C1" modified="2022-01-19" version="1">METIAVWCKCNQKVWLNYSTAQKSILDTVEMFKKENQNTEEKEACDAVENEERMEVTEESQQEHATLQTERRQRPSRSPNYFFAIRITDPVIRRCVXRIQNAVCDEEPRLENWRTDTARLHLTLCTTGLDGQEDMSKAIQVLKVLQGDISSLLSLVTMLRFQGLDQFHGRILYSAPEESPALAKLSQMLQVGLAEAGINLAGNRPKFSPHITLLKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSY7</accession>
    <name>A0A8B7YSY7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MAM and LDL-receptor class A domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110982363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096408.1">
        <property type="nucleotide sequence ID" value="XM_022240716.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982363"/>
    <dbReference type="KEGG" id="aplc:110982363"/>
    <dbReference type="OMA" id="QPGLACF"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000182">
        <property type="entry name" value="MAM and LDL-receptor class A domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00740">
        <property type="entry name" value="MAM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="218"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="385"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="548"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="716"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="901"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="1070"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="1231"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="1431"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="5">
        <location>
            <begin position="1638"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1091"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1095"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1414"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1597"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1604"/>
            <end position="1622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022096408.1"/>
        </source>
    </evidence>
    <sequence length="1733" mass="191659" checksum="B85E0C56F659B55A" modified="2022-01-19" version="1">MCNFEGTICDWTQLVTDELDWQAQQGMTRTPWTGPARDHTTGLSTGTYLVLETTGASNGNRAFLASYAIQAVTSTDCKIRFYYHMYGIDIGTLTVYFWDTTNGPLTNIWSMSGEKGDFYERAEIILSHNKPFQVLIEATVGGKYGDIAIDDVSFTPACKAFTGNFPSVPPPTKIPINPTSNPCLPAQFACADGSCIDVLLVCDGNDDCADKSDEANCGNCDFESNQCGWSGITSGLYQWERRQSTDTAKPHAPNTDHTTGTGWYMFVDSTTATFLTTAILQSPLLGNRGSKCEMNFWYHFQGGTDPGSLIVSVYQNSLPDSTTVIKSTSADQWKAGKLQVGPRAANTYTIRFEASPGSSFLDPTQLTNIAIDDITFDKCGVDSDLNCDFESKTICGWKQITADDFDWTVQTGGTASTNTGPQFDHTLGTAKGSYVYIEASVPRQKGDKARLSSGDMAPNTEYCLEFWYHMFGPDIDTLNVLQRTASGVETNMYRKQGTQSNVWHLARDYVTSTETYQILFEGIVGKSWGGDISLDDIKLIPGQCPPSHECEFEQDMCTWMNDQTDDFDWQRGASGSASAGTGPPTDHTLGTSLGYFMYANVLVPASQPTAGKDARLMSAIYQPGGDRCLVFWYQMVGDNVGKLSVYQKEEGDPFANPLWSKTGDQDDHWRVEKATVSSVGVKDFRIFFQATTGSATSGFIALDDIDVLDGACPPDGYCDFEIDTCTWSNYRGAEDDFDWLRNNGGTPSYQTGPSTDHTTGTGRGFYVYLETSSPRVKGEKAWLVSEHIDQTAGRCLSFYYHMFGGTVNALNLYTQTSHTGSSSSPQLAWTKKGNQGNVWRYAKATLSTLDEFWVIFEGVVGTSYTGDIALDDIQLLDGPCPPTQPPPTTPTPPPVYPPDSHDCDFENGFCSWTQLTSPDDQFDWRWQTGSTGSTNTGPVADHTNGDPSGWYIYIEVSGQSQDNIARLSSAYFPAATSTDPDGYCMEFWYHMYGSHVDKLTIYSVSYPDNKESVVWQKMGTFGPQWNQGLIHFQETKQYKVILEGTAGPSYQGDISLDDLKFHKGICPPGELCDFENGFCGYEQDKTDDFDWTLHQGHTPSQGTGPSNDHTYGTSSGHYMYAEMSSPRQPGDIARMDSPKYSKTPGSCLQFWYYNYGTDIGTLNVYKKTFGKYETIFTRDYDNWPEWHVAEITLQSISSFQVVFEAIRGSSWQGDIALDDIRVRDGACLPYGNCNFEAGDLCTWKNAEFNVDGFDWVRQKGSTLSSKTGPSADHTFGSPYGTYIYIETSLPRQEGDTAILLSGFFEPKEYCLEFWYHMYGGSMGTMNVNIWPDQNLFTASGDKGNLWRQAKVSVVPEIKQSFELVLEGIVGTSHTGDMAVDDIVVLDGKCPADIPPCDTVCKDDSSKCASKAQLCDFVNYCDDGTDEENCGTQCTFENDECNWNKVNSAAFEWKRQKGASPAANTGPDYDHTTLSEKGYYLYCAASANTGKGWAVFYSPLRHNSAASCELRFWYHMEGADIGQLRVLLHEETINLVVLHISGDQGGQWKEGVAPIGRIPGAFDVDFEAIRSFETEGDIAIDDVSLTGCQIPQPVTGDCRSTEVKCDSGACVHQSRVCDFSDDCSDLSDEKINDVCVNYDRCDFEDHFCEWAHVEHSAFKWSRTKGYTDDAWGTGPLRDHTTNSNQGSYIYIDSSSANYKDRARLASPPLQAIQSGDDCQVGKLLGGWFASWSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTE1</accession>
    <name>A0A8B7YTE1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110982466</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096563.1">
        <property type="nucleotide sequence ID" value="XM_022240871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTE1"/>
    <dbReference type="GeneID" id="110982466"/>
    <dbReference type="KEGG" id="aplc:110982466"/>
    <dbReference type="OMA" id="GRCADRT"/>
    <dbReference type="OrthoDB" id="5977230at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995:SF7">
        <property type="entry name" value="BURSICON SUBUNIT ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33995">
        <property type="entry name" value="PROTEIN CBG18546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034474566" evidence="2">
        <location>
            <begin position="24"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096563.1"/>
        </source>
    </evidence>
    <sequence length="326" mass="35942" checksum="ED27FF87BCF4760C" modified="2022-01-19" version="1">MRVSMTTVAMTVTLLLVSTATTGIPLKTSKAEIVTDTGLKTTDNQTPPKHGSIHQNERMTSKDVVSPIAQYVNDGQDLSASDSDNRQQRTSPLVSESYADDEKNQIPTRIRRTSQCRRQTDDELMDILQSLGQVNTRYADKSHQGFTSLMSFGTNEELDRLTKLQIEAALRGNPSAKESLPHPHINAIRTNLVTPEEANVPRIRRSVVGTTVSNFCILSGQEATQGFMRMCDSCPATTELSDDLFPRYVNEVVCSSNTDCLSGGGRCSERTLNITVLRRTEHCSVAANTSTTGQVLYVEDWEPAEQRIRVACECDVGIQSVFATYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTW1</accession>
    <name>A0A8B7YTW1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alpha-1D adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022096738.1">
        <property type="nucleotide sequence ID" value="XM_022241046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTW1"/>
    <dbReference type="GeneID" id="110982556"/>
    <dbReference type="KEGG" id="aplc:110982556"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018134">
        <property type="entry name" value="LAMP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00310">
        <property type="entry name" value="LAMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="40"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022096738.1"/>
        </source>
    </evidence>
    <sequence length="351" mass="39312" checksum="C9D539FEB193C5EC" modified="2022-01-19" version="1">MDETTIATTNGTKYPIYLSFTERTLFSAYLFIIMFIGFVGNVTVVFLVLSVKKLQTVTNVFEVNLAVADTLTCLVASLSAVIVLSYELILPMWLCQCIAFGLLTFIGCSLNTLALIAVNRLVAVTDTARIRYRKIYTCWKLTVMIAVAWAIPIFVALIPVFSDYADLGYDPRFSTCTWLSAPVDGLIYSFFVAAVFYPVQLTIVTASYVRIFLFVRSSTRKMTLRGTPQCGTPSSLQKQLSKRQLAVTKNLFLVVCVFLLCIFPYFFVLALDSIAYEALPYTAVLLLTNSCLNPIIYGTKHPDFRVEFCRLFNHFFGRCRSKKAKTSEESSHSVPSSSVKMATRDTKDTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUJ9</accession>
    <name>A0A8B7YUJ9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetylneuraminate lyase</fullName>
            <ecNumber evidence="5">4.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="primary">LOC110982687</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23296"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:17122"/>
            <dbReference type="ChEBI" id="CHEBI:173083"/>
            <dbReference type="EC" id="4.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-sugar metabolism; N-acetylneuraminate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DapA family. NanA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.3" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022096978.1">
        <property type="nucleotide sequence ID" value="XM_022241286.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096979.1">
        <property type="nucleotide sequence ID" value="XM_022241287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUJ9"/>
    <dbReference type="GeneID" id="110982687"/>
    <dbReference type="KEGG" id="aplc:110982687"/>
    <dbReference type="OMA" id="YLYHIPP"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008747">
        <property type="term" value="F:N-acetylneuraminate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF21">
        <property type="entry name" value="N-ACETYLNEURAMINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="12">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022096978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022096979.1"/>
        </source>
    </evidence>
    <sequence length="309" mass="34369" checksum="85255C5B95435B46" modified="2022-01-19" version="1">MMEGFKVKGFVAAVFTPMTENGDVNVEAIDQYATQLLNDGVRNVFPCGTTGEGLSLTINERKQIAEKWMQVGKGKFDVIMVHVGADSLRDTQDLASHAASIGADAISVVSPTYFKPKTVDLLLQYLKEVGAAAPSLPLYYYHNPGMTGVKFSLESIWEGLKQTPVPSLRGVKFTCSDFYDLARVQHLAGDRLQMLYSTDEQLPQAFSRGIEGFIGSTYNYAGKPANRMLEAYQKGDMEAMEKEYMMYLSFIPILFKYGGDVGSNKCIMKLARCPTIGPARLPIATLDKERLQSMNEELKNIGFFEWINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YW06</accession>
    <name>A0A8B7YW06_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intraflagellar transport protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">LOC110981836</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT56 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095486.1">
        <property type="nucleotide sequence ID" value="XM_022239794.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095487.1">
        <property type="nucleotide sequence ID" value="XM_022239795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YW06"/>
    <dbReference type="GeneID" id="110981836"/>
    <dbReference type="KEGG" id="aplc:110981836"/>
    <dbReference type="CTD" id="41905"/>
    <dbReference type="OMA" id="FIIRRDY"/>
    <dbReference type="OrthoDB" id="95390at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000588">
        <property type="entry name" value="Intraflagellar transport protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000271">
        <property type="entry name" value="Tetratricopeptide repeat domain 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022095486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022095487.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="61651" checksum="D06321B9A4E43E9A" modified="2022-01-19" version="1">MRDYTGAITLLEFTRSSGKGSDETDMWLGYCHFHLGDYKLAMEEYEKMSKKEAVNPEVWVNLGCCYFFLGMYPEAETAAKKGLDKSSHQAVNEDGMPKSSLQNRLLFHLSQKFNDEKKLMSHHQNLQDIIQDQLSLASIHYLRSHYQEAIDIYKRILLDNRDYLALNVYVALCYYKLDYYDVSQEVLAVYLQHYNDSAIALNLKACNHFRLYNGKAAEAELKNLQDLASPSFTFAQDLIKHNLVVFRGGEGALQVLPPLIDVIPEARLNLVIYYLKQDDVTEAYNLLKDVEPTTPQEYILKGVVNAALGQEQGSREHLKIAQQYFQLVGGSASECDTIPGRQCMAACFFLLKQFEDVLIYLNSVKSYFYNDDRFNFNYAQAKATAGNYKEAEEIFLLIQSEKFKNDYTYLSWLARCYIMNRKARLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYAAKAFDVLERLDPNPEYWEGKRGACVGVFQQIIAGHEPRETLRDILQILRNTGNPQVEYIIRIMKKWAKDNRVPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZK2</accession>
    <name>A0A8B7YZK2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110982476</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022096626.1">
        <property type="nucleotide sequence ID" value="XM_022240934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZK2"/>
    <dbReference type="GeneID" id="110982476"/>
    <dbReference type="KEGG" id="aplc:110982476"/>
    <dbReference type="OMA" id="TVEYRMS"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="130"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="253"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022096626.1"/>
        </source>
    </evidence>
    <sequence length="395" mass="43260" checksum="BF72779228BD86C2" modified="2022-01-19" version="1">MPMAEQNHNCVDMDDENTFLFTSESVGEGHPDKLCDQVSDAVLDAHLAQDPYAKVACETATKTGMVMVFGEISSNATVDYQKVVRDTVKEIGYDSSVKGFDADTCNVLVAIEEQAGEIAQSVHIDKADDDIGAGDQGLMFGYATDETEELMPLTVVLAHGLTRKMAELRKSKAVPFLRPDGKSQVTVEYKQKEGHLIPLRVHTIVISAQHDPDITQETLRKALKEKVIDAVIPAKYLDENTVYHLNPSGSFIMGGPKGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDVSKVDRSAAYAARWVAKSLVAAKLCRRVLVQVSYAIGISEPLSVFVWSYGTSDKSEKELLKIISDNFDLRPGAIIRELDLRRPIYQKTASYGHFKEGFSWEVPKKLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZK4</accession>
    <name>A0A8B7YZK4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110983299</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098132.1">
        <property type="nucleotide sequence ID" value="XM_022242440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZK4"/>
    <dbReference type="GeneID" id="110983299"/>
    <dbReference type="KEGG" id="aplc:110983299"/>
    <dbReference type="OMA" id="ECMTREI"/>
    <dbReference type="OrthoDB" id="6288762at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46253:SF1">
        <property type="entry name" value="TAB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46253">
        <property type="entry name" value="TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN TAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="535"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022098132.1"/>
        </source>
    </evidence>
    <sequence length="565" mass="62442" checksum="689BB5352277A42B" modified="2022-01-19" version="1">MAIARDKELFIGDELSASSLRDLQLRFPEIPTDVVSSFLKKNGGNMSRCIEELEHASPSYMYGEFVSHDTPAHEDQMTQNTPPRTRVGAAAYPSQFYSPERGVPVHAPNTDLYYPQGFHHMRVEDPERTPQPSYTSWASLETGVPGLEMPVETRQNPLSVAAEQRHVTSCTLDIQKPPLRTVSAPNAEIGQSGSPVPVGSRYAEGDALLRQSSHASSLYGRTTANGLEQRMDPKDFPFEPRPSWQEDPQPFAMAGHEAVGDRWMPSQPKVRPTESGSGIQIATSYQLDPLQPSSPATKPRKGKPSPSSSAVASYSKATEKISFNPNLSRTPAQEPLRASSMPNDGAAAHQTAANLSGTSLGGGEPDPPKRKERSKRKDANLAPPSLQQERSASKEKEDQAYTEALIMHQRARYERLSKELEDERKSLAFMRDETSHMENEVTLKRKNHRAPFPTPEEIGKLREQKHQLQIDIECMTREIESYKSQGLMDVAKATSFYGNIGSTGAPGPVPPIVSQSNAIPENITQIDTEVPPPPYESLMWSCSACTLLNHPDLDKCECCEMPRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z187</accession>
    <name>A0A8B7Z187_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110983630 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110983630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098732.1">
        <property type="nucleotide sequence ID" value="XM_022243040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z187"/>
    <dbReference type="GeneID" id="110983630"/>
    <dbReference type="KEGG" id="aplc:110983630"/>
    <dbReference type="OMA" id="VEECYIL"/>
    <dbReference type="OrthoDB" id="6482909at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF272">
        <property type="entry name" value="KELCH-LIKE PROTEIN DIABLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="405"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022098732.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="57238" checksum="1C2CEB74389CC943" modified="2022-01-19" version="1">MPTELKALKMANRVNIGGSPKRSSATVTKATGSSTRRPRPASYHQDHGSSSTSSGSPKSPSDTPKGSLVKSPATGREAIASLALKIPPRVDRTWRRSGSPSARSSASGSSTGSSDSLPSRKATSILRKLAVMRQEEKLIDLNLVFYRGEIRCHRIVLAASSPYFRDTLAVSSHLTRHDSIEMRGVDMQVMQALVDYAYTSTVTIGYDRVKTLLEAANMFQFQSIIDACIDYLKRSRRKIRQRSSSRQRSENSVGGASPSSGGSRSASPKSTPVQSPRAGSPLTTPSPLLLSPREPFNGSSPKIAITDDKVGDVAKILQDISLEGKGATTTDAEDGVMKNNGLPSALDVGSKYSRSISTGSEGYLTSSIGSDSSNDSTTHFIFRDNRHPSHFIKAMVKLRQEGRLTDVVLRTKIKDFPCHRVVLEASSSYLSQVISRDLDGTNAMDVHMRKISPDVLQKLIHFMYTGRVAVSDRDAAQVYRAAKRFGLDDVCHSCAVVDPSLDSTSTANTSLTDSVLSEATHPGSLENLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1T2</accession>
    <name>A0A8B7Z1T2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 5B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099564.1">
        <property type="nucleotide sequence ID" value="XM_022243872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1T2"/>
    <dbReference type="GeneID" id="110984071"/>
    <dbReference type="KEGG" id="aplc:110984071"/>
    <dbReference type="OMA" id="MSSAWHA"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022099564.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="32891" checksum="541FC392584E50E7" modified="2022-01-19" version="1">MGKPRKGRNTRGADEDSDGEIDLDPIAKAMKEIDDDIASAKAGGKKGKKKKKKDVDELFDELGAMGGDGEMAEESGNIPDEEETATKGKKGKKGRKRKDDWEVDDIAKELEDLKMEEKKEKGDKGNKKVENIATEDMDGGDQDKETEDHNVKKPTDDDEEDGEDGPVIKTAAQKRAEKKERERKKKELQRAEARNRRQRQQTKDVDKEEAQPEGDRAASETTQAEAKLEDEEAQEDGDKKKRKKKKKKGKDEDDEPEEIKESSEITAADEEAKRGEVASLHPQLEVHQLDLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3U7</accession>
    <name>A0A8B7Z3U7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110984113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099632.1">
        <property type="nucleotide sequence ID" value="XM_022243940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3U7"/>
    <dbReference type="GeneID" id="110984113"/>
    <dbReference type="KEGG" id="aplc:110984113"/>
    <dbReference type="OMA" id="NLMEERT"/>
    <dbReference type="OrthoDB" id="6157510at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040350">
        <property type="entry name" value="TMEM272"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33444">
        <property type="entry name" value="SI:DKEY-19B23.12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022099632.1"/>
        </source>
    </evidence>
    <sequence length="270" mass="29438" checksum="11AAE937C6309344" modified="2022-01-19" version="1">MHNDLAIARVGLSPDASITASIEGVTRPQSTEGKQRVSPSPVETMADAEKGLVGADANAEAPTYGSADTSATGKPPPFDEVPGEEPPSYSSVMQELRDAKKTSSGTVDFITKVLTILINTLLFTILMGVALIIPIAMVVMGAVHINHCPVQKLIPIFLIVSGSVYIVKTILDLVVRYRRRKEGGAAESSYLKENAVSRLFACILLVFFILGNVWVYANFRPDDDPSSPRYCYPPLYYFAFWIITLTYIFFFLSCCCACCTVSLLFLSLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3W6</accession>
    <name>A0A8B7Z3W6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Tumor necrosis factor receptor superfamily member 11A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110984434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
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            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
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    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100328.1">
        <property type="nucleotide sequence ID" value="XM_022244636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3W6"/>
    <dbReference type="GeneID" id="110984434"/>
    <dbReference type="KEGG" id="aplc:110984434"/>
    <dbReference type="OrthoDB" id="9950067at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052491">
        <property type="entry name" value="TNFRSF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46330:SF6">
        <property type="entry name" value="HEMATOPOIETIC DEATH RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46330">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034101904" evidence="10">
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            <begin position="27"/>
            <end position="298"/>
        </location>
    </feature>
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        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="11">
        <location>
            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="7">
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            <begin position="38"/>
            <end position="82"/>
        </location>
    </feature>
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            <end position="124"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="226"/>
        </location>
    </feature>
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        <location>
            <begin position="183"/>
            <end position="205"/>
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            <begin position="61"/>
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        </location>
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            <begin position="64"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
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            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
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            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
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            <begin position="106"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022100328.1"/>
        </source>
    </evidence>
    <sequence length="298" mass="32865" checksum="ACE7A4FADA936CF2" modified="2022-01-19" version="1">MATFKKNGAVCFLMLVVLFSERATFAKHHPTQGSAQLRCRYGMFDDRQRGAEDGKLNCRPCSRCLPGYQASRLCSWSDDTECSPCLPGYYSASTSSVDACLPCRTCGQHQPVLHACNASADTICSRHCSAGYFYSPLDDDCLPCSPCQNHPLYQERMEECIASGMGTDMQCWPLPTLIMGSQESQSDTIGESDNKSPSTTVASQSDYHKRPAASSPRPRKLCKDDSDLDRDTRQVYVVVLLVVLVVGGLCAVLSVTIIICLCRFTKMVSRSPKRTGKSGYENISRKTSELLVRQPTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z418</accession>
    <name>A0A8B7Z418_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110983276</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098096.1">
        <property type="nucleotide sequence ID" value="XM_022242404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z418"/>
    <dbReference type="GeneID" id="110983276"/>
    <dbReference type="KEGG" id="aplc:110983276"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022098096.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="23890" checksum="19CC7ABF13FAC0CE" modified="2022-01-19" version="1">MPETAIPAPASQTCDEWSLLDDLFVPEADIDLELYQDDSEFAGALSTQPPIPTPSVPSHAGRHHSSYARIKTEYTSSYPRYQSADYPPYQACHGFFPHGVTERDLAFLPYISSDSDVSGVTRLSIKSEYTTTTSAEYSSEFDYRLPHPWARAPSSETTVSYSSTVHQPAEHRLGSIVALAIRGSLSLDFDESALQAIERSVRLLDRQRPDDHMCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5Y5</accession>
    <name>A0A8B7Z5Y5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984374</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_022244518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5Y5"/>
    <dbReference type="GeneID" id="110984374"/>
    <dbReference type="KEGG" id="aplc:110984374"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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            <begin position="186"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="335"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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        </location>
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        <location>
            <begin position="718"/>
            <end position="855"/>
        </location>
    </feature>
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            <begin position="191"/>
            <end position="203"/>
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    </feature>
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        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
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            <begin position="350"/>
            <end position="362"/>
        </location>
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            <begin position="371"/>
            <end position="407"/>
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        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="445"/>
            <end position="466"/>
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    </feature>
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            <begin position="479"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="794"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100210.1"/>
        </source>
    </evidence>
    <sequence length="855" mass="92163" checksum="EC59C7328377CE64" modified="2022-01-19" version="1">MAQTNWSCYGSSDGRNERPTMNVLQTEGERLHEQALSSYAHGNFAQAKLLLEKAIALEPYNASFRETKNSFCQANQGPYTYGHHQTGTGRSFLDGEQQKQQYGRGTATSWNSSLARQSWDSGGPQGSATFLNGNNYKARSVRGPWPQQPSGNAAQYFSNTVADSMFSPYWGRSEDFQSLGMNSHFGDPRASQRQTNVSHTGRTNVGPHYTKASNTSQQDGMWGTWTDPAAESDPKPEMSWVNSGYQQSDIPWTPEPRRAASLPNNIRSGANGSTSQSSLRGSMANSTERFSSKGHHGQSSPHTWRSEETSSETNYGLDSFDEVSNMDKVEEWMVKNEASGVPNPPPGLSKPRKNKKKKKKKMPAAPKQESPDTSLQTDKDVSQYSGRSSIIECQNPARTKSASARSCQSDETKSVSKNASYHSPSSKPRTAPFTAESVINSNSDKLSKHINDNPHHSKGFKEKDKSFFDPKRIFVSSDFVRTSQPSGCAGQPDSSKQSKTKSAVSKGEYNTSRKSAFSSKGRREGDGVKATGGSPEDLTNARTTGSRDQTYSCDPQETEADGLADDMERSRLDSSGSLGSEVSGRMTKEEWEEIIKRMYAPLGMPSSSPQEHPGRANGAPSEPTSWEQSPAFQNCGRNFVMPSNTEACALEGGLLPESETVQKLSKMKAGRVNAAEKGCSGSKQGAYVDVKATLGAGILQNSVPVCHADTSIRLTSPAGRQSKILSSEKCKTTESAQSAQASTSCQVPLTKGTGPVPQREKTSPENVNSSFAKPLEKPKVEVSSASSVISGRDATSSKGTSKSASNFSAEPKVEVCSTGLVTSSKVASGGDDVSPLKGTTKRSPEPRVEVSSQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z6X3</accession>
    <name>A0A8B7Z6X3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Trichohyalin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC110984555</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100539.1">
        <property type="nucleotide sequence ID" value="XM_022244847.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100540.1">
        <property type="nucleotide sequence ID" value="XM_022244848.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100541.1">
        <property type="nucleotide sequence ID" value="XM_022244849.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100542.1">
        <property type="nucleotide sequence ID" value="XM_022244850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z6X3"/>
    <dbReference type="GeneID" id="110984555"/>
    <dbReference type="KEGG" id="aplc:110984555"/>
    <dbReference type="OrthoDB" id="10007527at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052825">
        <property type="entry name" value="CCD-Prefoldin_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031476">
        <property type="entry name" value="DUF4686"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34479:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15742">
        <property type="entry name" value="DUF4686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="940"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1190"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022100541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022100542.1"/>
        </source>
    </evidence>
    <sequence length="1200" mass="140616" checksum="0E01EF9101606037" modified="2022-01-19" version="1">MSRPTAVNGILTNKNELDEINRRLKQNGIDPRIGDQAKLQELWHLFARTEADLLTSKQALSGAERQHAVEMQEVESYMEQVRHLSEERDALTQEFEMENDQLKKDVEKLRQEIADGKREVTQLLIQEGFMDLADGTPSEAIAYFLVERTRTMDELREAKRKAASSPGGAITTSKQVQEVLDKERKIMEEEMRTEREKVRKMKDSIEQIYAKELNKVKADSKLKITSLESQKRRLEQEARHHHQKTRDLEFEMDRLKKSLEREKKERREEVEKLQQQLPGSPRDLNQSELSQLREAKKKLEMELSTTKYRLKTGEEDKHKLNQRVKELTESLDTEKKRRSSYEGTIIKLKSVVDRNKKLVTSLEDEKQTLSEEKSALQMRIGFLEKDLQELKEQERSLRNQTTSLKSEQTIIERQESEIKSLREEKEQQALKLQRTMVSLETERRKCLELGEKLTSTEEKWEQIVQRYKNNEKDLANKLDKLTRDLDFSKSELEANHQRMHQIQQEHDKQLEDARGETQTLKEQLQQEKGLSNQADRHRETIKELEGIVDELKKDRDVLARELQIMIGKEQKHKEKMMSIEQSAEEIKRLEAQLENSVMKQSSLVEELSEEKKRNQKLQDQLNFSQETLKIAEQSTDHLKESIGRKSAELVKQYDWSKENQLKLENKVKSLQRELDEARSMTHQDKTAVSWRLEREEKRVKELEDMLTEKKEELVEARRESGRILMNQTRAEERAQEEARLRLDVEQRNKVLEEEMTKQWTQLKDLMARLTANESAKQELEVQLEKQTNETRQRYSEIQQVQAETNATTSTLSVVQQRAQAAERKIPELQQQLDEKSLRLQATEAQLRDLTSTKIDLRTCKDDINRLKAQLHEERIDKSLLNQQLEDAKQQVAACIEREERLRHENSDMKHRLIETQNKLYATEDKSKSVEDMHSLAEQGKKSLRDQVSSLQQEVQRLQTELMQTSQRLDAQITKYEEHKLHHKNKIQQAREIFTRHKSVLADSLMKLQQDLNTTNAELQKEQNNRENLQKKHDSLLEEHRKLLALHSDAEEAVRDQNRNVSTMDYRVKYLERENGVLQDRIDTLSRQRVAMEKLIREYRLEKQKQEIDKSLLVSSSGGLVFPSSPLSTLNSTVPKTTLTSGLGLSQSPSYISTHDPRFTNSSHSLRSSQPGRIPGHDLSPANRELLRSPELSNTQSSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7P0</accession>
    <name>A0A8B7Z7P0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAS-associated factor 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101674.1">
        <property type="nucleotide sequence ID" value="XM_022245982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7P0"/>
    <dbReference type="GeneID" id="110985160"/>
    <dbReference type="KEGG" id="aplc:110985160"/>
    <dbReference type="CTD" id="11124"/>
    <dbReference type="OrthoDB" id="1920064at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17130">
        <property type="entry name" value="Ubl2_FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01771">
        <property type="entry name" value="UBX_UBXN3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033043">
        <property type="entry name" value="FAF1-like_UBX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF96">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="587"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="504"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101674.1"/>
        </source>
    </evidence>
    <sequence length="667" mass="75538" checksum="8F0A5B00928A7CBF" modified="2022-01-19" version="1">MPSYDHHCMLRIDAGVACFCRSKRWCVFEKACTGIENFEESLAHLEQNEWDLQRAVVSVMGAQDNVSVPDSAPEEAPAAPSMPSVVQFSGVSPCASVPRAFDPRRPRSPPPNRVRLLEFTVSYNDLNTELVVEDNRTVRTVKELLSAQLNLSPEKMLIGGWAHAKQAPEDSDVLSSLQLPLKNSLYVLTPSLPTTSSEQPNGEETSFSDKLTRSFELIINDTDVNQEYRLKYQGCKTILSVKQGMSALTSVEVRHQQWHGWPDDSDNSLTLAASGIDFPNHKLTFSRLPNHSKTDQSSKSGDPINISDSEDETQDMDIDDCTIFTNEYETRKFEPLLPADIENETDGLIQFTHEFSSRYGETHPQFYMGPLEDAVKEAFGGLAVERKLLAIYIHTDKSVQSNVFCSQLLCAESIVNFLTQNFVTWAWDITADENKDRLLSTCTKMFGSVTAATVRGLNQDKFPLLLIVMRIRSNTEVLSILQGNTGLDEMMTSLIHAVDVFTEQRQSEIEQENDRRAAEQLKQEQDAAYHASLMADRAKEQERLKQEREEQRLRELEEQEIREREAEQKALLESLEQQLPDEPAENCPKPTTTLRMRMPGGDVLTRRFLAEQPIRTVMVYLGTKGYHSEDFKVLTTFPKKDLTSQDTSQSFKELGLCPQETLFIEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7Q0</accession>
    <name>A0A8B7Z7Q0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Receptor-type tyrosine-protein phosphatase alpha-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110985162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101684.1">
        <property type="nucleotide sequence ID" value="XM_022245992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7Q0"/>
    <dbReference type="GeneID" id="110985162"/>
    <dbReference type="KEGG" id="aplc:110985162"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022101684.1"/>
        </source>
    </evidence>
    <sequence length="163" mass="18821" checksum="D8302AB6460F2D28" modified="2022-01-19" version="1">MYHTLLTETVGKNKQQFEAFVVKIYIDVHALQDDIKMEYWSINPSFTCSLVYVFNFFLHLFFSAGVGRTGTYICLDSVLQQMNQEGQVDVLGFIYRMRQKRIMIVHTSAQCQFIFDAFLAASLTGETTNKIANFRRQLTTMKNVQGRSKETGTEKQLRFASDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7T4</accession>
    <name>A0A8B7Z7T4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rho GTPase-activating protein 100F-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110985187</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101719.1">
        <property type="nucleotide sequence ID" value="XM_022246027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7T4"/>
    <dbReference type="GeneID" id="110985187"/>
    <dbReference type="KEGG" id="aplc:110985187"/>
    <dbReference type="OMA" id="ATTCQKG"/>
    <dbReference type="OrthoDB" id="120383at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06718">
        <property type="entry name" value="PDZ_Par6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052118">
        <property type="entry name" value="Rho-GAP_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057459">
        <property type="entry name" value="SYDE1/2_C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46150">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 100F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46150:SF3">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 100F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25336">
        <property type="entry name" value="C2_SYDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="138"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="614"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="774"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022101719.1"/>
        </source>
    </evidence>
    <sequence length="1083" mass="120762" checksum="C9A679D36ECE7F52" modified="2022-01-19" version="1">MTDRGSRRSRTLSDCQNVERGTKKLSSRSQSADYWAGERDQPSSLPTTGGHDGGGGTGGGAMQIDTPAGFRHVSGITNEMVSTIQAAERELFTDLSRAQAFEDTDATFAVFNRPNNGKLRISVAQEREILGGAYLLRTVEITKIPGRTLGFFIREGDGLDRRDGIHVSRLMLGGLVEESGLIQIGDEILYVNNVDVSRKTLDEVYMILQIPIRLLITLKSRQIGKGVFRSSWGSFTSDNISPGRFSPAALGLGSKQRSISVGTNSSLGSMSDRSPGSFTDGSQSGLAVQFEDKENSLRCKGSNQHRLLDLKGPRAAHYHDLDLHEESEQQVQSALEPDMAGSSTTSSSSNSSAIGGGRAPAPPLQVPVRDFKLRHLSASDAQHESETPKPETFHRAASFDPSTLPAEEDSDNMVFVDDEDYDDLREIPDTEVDSFTNVHGLRSSVPVYSSRKKQRPYSAFIETDHKGFSKEVDDIRKDAQMMDKKQSSGKLRRASSSDDVIAALTTTTKPRGNANRQHSSAGDSRTVRPRSAILEFLPNAMRRSGEGKARQRKPGQVEKTTKSSLMGKKADKNSAEATAEDGSRYVPKPSPDKKTRRISASKPLDIDATQFTKYKSDLGSRLRNRQMPLSGILTLHLYGSRKMAPSLSSRKENRDLYCVMEVDAVHKAQTATVSGKDEFCWDEKFEIDLERAHDLSLLIYSYTDWDTNRQKLCYKAVVRLTQLLMHSTRPKDEPFRLAVRLEPRGIMYAKFSFTERHVTLKRVPSLDRRGLFGVPLEVVVRRENTHTNIPIIVQKCIEEIELRGINMVGVYRVCGSAKRKKRLHDEFEASSSLVDLSRENYPDLNVITGVLKDYLRELPEPLFTTKMCQRFMDTFGNQSADPACDGEKLVQMIESLPPANRTTASYIMDHLKLIMVHSETNKMNAYNIAVCFGPVLMSAASSGSNAALSREAVSGKDADYEKHIDVLQTMLEVWPGKRADFDKIQQRIKEQQELLEEEERPEAEPDHDPFLDNDPLLDNQEEDSCYHSNDDLDETLRAKDGDEDGGKPCLQHQQHQEAQEQQQQPQPDGEDEWDSDNLQVSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7V9</accession>
    <name>A0A8B7Z7V9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110985205</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022101743.1">
        <property type="nucleotide sequence ID" value="XM_022246051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7V9"/>
    <dbReference type="GeneID" id="110985205"/>
    <dbReference type="KEGG" id="aplc:110985205"/>
    <dbReference type="OMA" id="ATMPIFN"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01801">
        <property type="entry name" value="Ubl_TECR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000131">
        <property type="entry name" value="trans-2,3-enoyl-CoA reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049127">
        <property type="entry name" value="TECR-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21696">
        <property type="entry name" value="TECR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="18">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022101743.1"/>
        </source>
    </evidence>
    <sequence length="304" mass="34263" checksum="DFEC4FB8F72BEB5B" modified="2022-01-19" version="1">MDIKILDSRSSKELLTLTELGKATTIADVKTQVHLKKRNLYPERQSLRTTAKGKSLKDDCTLESLDLGSSGKLYFKDLGPQVSWTTVFMTEYTGPLVAYLLFYSRPAIIYGAEAASAPRHPVVQIAAACWTFHFAKRLLETIFVHRFSHATMPIFNIFKNSSYYWGFAAFVSYFINHPLYTPPAGGDLQIYSGLAAFLVCELGNLSIHVALRNLRPPGTKERRIPKPTSNPMTFLFSMVSCPNYTYETGAWIAFSVMTQCLPAVLFAVAGFGQMAIWALGKHRNYKKEFSNYPRQRKSILPFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z934</accession>
    <name>A0A8B7Z934_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DC-STAMP domain-containing protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110985453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102179.1">
        <property type="nucleotide sequence ID" value="XM_022246487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z934"/>
    <dbReference type="GeneID" id="110985453"/>
    <dbReference type="KEGG" id="aplc:110985453"/>
    <dbReference type="OrthoDB" id="5985669at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012858">
        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058842">
        <property type="entry name" value="DCST1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041:SF9">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26039">
        <property type="entry name" value="Dcst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26037">
        <property type="entry name" value="zf-RING_DCST1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="7">
        <location>
            <begin position="576"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase DCST1-like C-terminal" evidence="8">
        <location>
            <begin position="823"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF26037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022102179.1"/>
        </source>
    </evidence>
    <sequence length="881" mass="98418" checksum="2429A53DF69E0E85" modified="2022-01-19" version="1">MLPFYPNELIVRYLLRTSTVKVKGLSSVPRAQDDSDMQSNNDAEAPQPGYRYFTPQPDRKRPLLPPVPSTSTPAVHPKIREDDAQQSIKESFSKATALVDTNKGKKSNAGLLPPSLNPEHRPGTRPQFLTPQPTRHNSNLVDRTPSVNDGSPVGPDARPALKNEHLTFLNSSDSPDLSRSPSPHTPISPLAAPAHKTKKTASQHSLDSGLTTESSPSPSPNIPFLKEIFLSDRKSHRKLKRIVGALTGLVLGGFLFLGLYFGLEYSLVASIVMTIMATIIMSLTLAFSVRARCVAALMIPTLCTSRGRAAFLAIIVTLLLTGPIGNIYTNAKVTSNSLSCSAELAQNQTLLIRDVAREIFDVYVQTLMDSVRNLQEASATFQDAFQPVENALNEFLETLGNAKETVRDTASRCEQVINRAYEDCIQASNDGYRGCRNSLGRVPNFGNARLNEACNSFNNFRQEVCDNLGNTDVVCEVPTFVDNLLDRADRVIQKALNDILQLFNTDVDFESYWENRLNQSQTFDSIQAAIQQELEDSFSFLNLAFAVIDKILALSIVFLLIRSYQYHSKYHTKDNFDNCYITEEFKLLDERRQKSGLEPLLPLKKSERRQLINSSAVSLSKPEKGLFKLGLVTVLLHAVIATILIVADHGLFWLLSLISRHGRVRFEISGEGGTDLTIGGSGVLSPLIQSLFVAGFEATNEFNVSLDTERCLPNPVPPNEILSVGIGVLYLIALVMVLLQAYALRLRRRIASYFYPEREQERIQYLYNHTLQRRQNLFKLLKQRIRETKHEMEVKQRVSFIAYLSAKYPFWRRVFCWLGQEKRVCLGCADVDNGTFKSCGNPDCSGLYCRECLHEINSTCTLCQEIVAGSDLSRGVVEHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9E2</accession>
    <name>A0A8B7Z9E2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110984228</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099881.1">
        <property type="nucleotide sequence ID" value="XM_022244189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9E2"/>
    <dbReference type="GeneID" id="110984228"/>
    <dbReference type="KEGG" id="aplc:110984228"/>
    <dbReference type="OMA" id="MIKNLMA"/>
    <dbReference type="OrthoDB" id="1580043at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051883">
        <property type="entry name" value="AQP11/12_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016697">
        <property type="entry name" value="Aquaporin_11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21191:SF16">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017529">
        <property type="entry name" value="Aquaporin_11/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034069653" description="Aquaporin" evidence="8">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022099881.1"/>
        </source>
    </evidence>
    <sequence length="273" mass="30076" checksum="FB7F81F2898EB223" modified="2022-01-19" version="1">MSLVFSLVILLSTFLLTQALRVATSTILPRSIYQFVAEFLCTFQLTSCVYENGIVLGTHGTWVYAFGIFCLGLGYSLTFDAFGNPAAIFEQILKRKISVLNGALKMAAEVVGGLLAFRYMLFVWHTFAPSSVHINHAKMVRVSCVSALQVNLLTGALVEAIAMFVSRSVAGIGLGGPKYYKMVNAFTTAVVVVSGLEWTGMMFNPALATALTYNCKGHQLYEHIIVYWMGPFIGTILSILVFYYIMEEYEQGQKSVPAHVQDKNGLTTKEKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9I8</accession>
    <name>A0A8B7Z9I8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WD repeat-containing protein 75-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110985550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102333.1">
        <property type="nucleotide sequence ID" value="XM_022246641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9I8"/>
    <dbReference type="GeneID" id="110985550"/>
    <dbReference type="KEGG" id="aplc:110985550"/>
    <dbReference type="CTD" id="84128"/>
    <dbReference type="OMA" id="WILNTRI"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="337"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="760"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022102333.1"/>
        </source>
    </evidence>
    <sequence length="859" mass="96237" checksum="E36856133CE3E9F7" modified="2022-01-19" version="1">MAAYREGRVVVRGGADLVKNRPVFSSDSKYIFVCSGHTVKIFSAASGDCVRELRAHDGEVTGVVVNPQNKLQVFTGSMDGTISQWDYMDSVLLKTLYVRSPVCGLFAHPSHPDSLFATIFDEKSDDNTRLKLVKIKIPKQAGQCVDVVDQFVTGNVQAGDKGVAFGARGEFIATIMRNTLKIVFMKDMHLKKLSPDRTPLTCIACHPSDYCIAVGDEKGRISVWRNFHKKERRALEHWHSLRVEDLCYSPEGSVLYSVGHECTLVEWRHETLQKKFLPRQGAPINHIAYAPNSQQRALSLMTNAMLIQSHLTTTQTIQGLVRTNFNQKREDYLPIGLVIDPHTRALVTNGMVGQLQFYQLDEDRLLFSLDITGENYISPADLQQPLFHTEVEKVAFDPPGDWMATVERRDDKQTSPELRLKFWEFDQLKQSFVLNTVISEPHASRINCLSFRPSSSVSHDTHEPMAFTTSDDGKFKLWAAASDDDSQKKGRSWGCESVGFFRDEIPSCACFSADGSLLIVSFGNVVTTWDPDVNVLKKTLCHGVNDQHIEHVVFGHGSAAHCLISASSSVLNVWNLLTCTVMWRVNMNVSVLVADTESEFVATFDRSGNLFVFHPLEPKLVYTKQNLPTPSVMAAVFIPLTRTDSSSSGGSHLLPWEEHSHLYFVTKGLMLMTETSQLHQQRVSHADMEERLPPTPFAMLLNNQQRKAEKEEGVRMQDLPASANMREMLQAPAHILPPVKSLCATFLQGLLDPGTKMLKRKEERDMDESDEDSDQKSDSEESDMDMETAGGGAVNQSKDTGNGTDQSQDSEDHKDQSELQARSGGQYRTQALSEADLRRLAKVSRSGLKWMHKVFQEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9Z4</accession>
    <name>A0A8B7Z9Z4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">receptor protein-tyrosine kinase</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110985230</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022101792.1">
        <property type="nucleotide sequence ID" value="XM_022246100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9Z4"/>
    <dbReference type="GeneID" id="110985230"/>
    <dbReference type="KEGG" id="aplc:110985230"/>
    <dbReference type="OMA" id="PHIYENH"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00192">
        <property type="entry name" value="PTKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000554">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.300.10">
        <property type="entry name" value="Tie2 ligand-binding domain superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF613">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="224"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="15">
        <location>
            <begin position="321"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="439"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022101792.1"/>
        </source>
    </evidence>
    <sequence length="726" mass="80138" checksum="CE1E4F65BF797667" modified="2022-01-19" version="1">MNIDDTLSSVNTGGAVDFTLVTNPALLGVTGDNDATIGAYKGHRDLTAAVSFGRQLTTGGTNSGLPSGSKELQSEQLGCQLRQIQLPEVDGLDRTGVFYCEATKPGRTVTKIQTIILPMDVHGRNIFGQNARHRCFNSTDPHDEACRGRLFCLPDPYGCSCAAGYTGLDCMQECAQGSYGADCKQTCHCAPGKTCSKDTGECSDDDCASSYYGINCQCSSREVAPGELRATEVLQCNVSFSWTKPTCVFRGGVITGFLYQLIDMRSGALLRLLNATEESVTLNGLSPYILYGFQIAATTIAGTGPFGELLSVTTLEAEPSAPVNTDVLDVDDVSVTVTWSPPDPPNGIILNYDIAYWKSTDAGSPTLRNDIGMTSIAYRVDGLDKFTTYHVQVEYRITEKPYDQTFAAGSEYTREYVDDPWYRKDTFEPGTKYEFEVSAQNQENAGKRSTAYVIRVQQELVKTKREAFVPRHYRDSAQDYIAAEIPDTDVTVPFTVGDSLIHASLYVVLEYLPNGNLRDYLRSACPNQEGTATPARVSPLTSSNLLTFGINISRGMEHLSNSGIIHRDLAARNILLAQDLTAKVSDFGLSRGEDIYVQQSMTRIPTRWLAIESLTHREYKSKSDVWSFGIVLWEIATFGATPYPGIQSKLLAQRLQDGYRMPKPQNCADEIYDLMMKCWQTDPHKRPSFKELSAALQAMNAQSDENIYMSPHIYENHVIQLEFDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCQ8</accession>
    <name>A0A8B7ZCQ8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-iminobutanoate/2-iminopropanoate deaminase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102630.1">
        <property type="nucleotide sequence ID" value="XM_022246938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZCQ8"/>
    <dbReference type="GeneID" id="110985717"/>
    <dbReference type="KEGG" id="aplc:110985717"/>
    <dbReference type="CTD" id="10247"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102630.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="14777" checksum="8C8D9301B30771F7" modified="2022-01-19" version="1">MAGLVRRIINTPKAPKAIGPYNQAIAVGNTLYLSGQIGIDPTTSKLLNGIEAQTTQTLKNIGAILETQNIDYSNVVKTTVLLADIADYGVVNQIYEKFFTSNYPARAAYQAAALPAGALVEIESIAILGELVNETLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZD52</accession>
    <name>A0A8B7ZD52_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">MFS-type transporter SLC18B1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12 13 14 15" type="primary">LOC110985780</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102775.1">
        <property type="nucleotide sequence ID" value="XM_022247083.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102776.1">
        <property type="nucleotide sequence ID" value="XM_022247084.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102777.1">
        <property type="nucleotide sequence ID" value="XM_022247085.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102779.1">
        <property type="nucleotide sequence ID" value="XM_022247087.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102780.1">
        <property type="nucleotide sequence ID" value="XM_022247088.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102781.1">
        <property type="nucleotide sequence ID" value="XM_022247089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZD52"/>
    <dbReference type="GeneID" id="110985780"/>
    <dbReference type="KEGG" id="aplc:110985780"/>
    <dbReference type="OMA" id="ERFPWAN"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF26">
        <property type="entry name" value="MFS-TYPE TRANSPORTER SLC18B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022102775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022102776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022102777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022102779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022102780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022102781.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="51088" checksum="7D2C0E49A0FFADF8" modified="2022-01-19" version="1">MDKCNPAPTQEYANSGQQAPTNADLTTPSTNRIDPGRQTGASEANEVDTPPKGPKFTYYQKATFASAVLANLANYMAFSIISVFYPINAEGRGVSQTVIGLVFSAFSLSAGIGSPIWGKTIPIVGARFVFLAGTFVTGCCSILFGSIAAMPTKETFTGFSLAIRLLGGLGSSACLTASAACVAYAFPENVGTAVSTVEMMGGLSCAIGPAIGGLLYDAGGFELPFFVLGAVVLVVNFINFFLLPEQGTKNEESGSLIRVLRIPAMWVALASTALAAVAFSVLNPTLSIHLKRLDFTVIQISLIFFGWGLAYAMATVIWGAVADATKATRIMMVMGAFGTAVFYLLLGPSPLLKIPSTKLVAILAIPFGAAMMALISIPPIVDMFDSAVWYGIPNNLGLSSIISGLWNGGVSVGLFAGPLLGGQLADRYGFAILSTVIAGCCLVVMIFICLFGVWEYQCGKGRRIPSSRLEAEANSTEDERRPLAATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE51</accession>
    <name>A0A8B7ZE51_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 23 member 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110986405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103943.1">
        <property type="nucleotide sequence ID" value="XM_022248251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE51"/>
    <dbReference type="GeneID" id="110986405"/>
    <dbReference type="KEGG" id="aplc:110986405"/>
    <dbReference type="OMA" id="VPYMGGS"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11119">
        <property type="entry name" value="XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022103943.1"/>
        </source>
    </evidence>
    <sequence length="516" mass="55846" checksum="908DC52C1F4FD238" modified="2022-01-19" version="1">MVPTFSILRTRGECPPAPTDNSTVEMSDAAEEEWLARIREIQGAIMVASCVQVVIGATGIVGILINFIGPITVTSVVTLIGLGVHKPAAEKSGKHWGIAVMTMVLIALLSQYMPEIGVPVLSCKSQKKCHMTRFKLFKLFPIILGVAVVWLFCVILTAIGVFPDDPNVYGYAARTDLNTMVMERAPWFSFPYPGQWGTPTVRLSSVLGMTAGVFASIVDSVGDYYACARMCGAPPPPQHAINRGVLIEGIGCILAGAWGSGNGTTSHSSNIGIIALTKVGSRVVVQAAGCILMFTGLLGKFSAFFATTPEPIVGGVLCIVVSMVTSVGLSNLQFVDLNSSRNLFIVGFSILMGLVVPYYLEQNPGILKTGFTEIDQIISVMLTTGMFVGGFLAILLDNTIPGTDEERGIHSWRQHITSDAGNEEEGAEPETDKNRDGGEGQDIELDVMHVPDQLQADVNEKGSSMQTASPDSYDLPLVMRFVRRWAWCRYLPFSPTFRGFKFGWMKKICKKKESVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGD1</accession>
    <name>A0A8B7ZGD1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serotonin N-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Aralkylamine N-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110985521</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20497"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55469"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:77827"/>
            <dbReference type="EC" id="2.3.1.87"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetyltransferase family. AANAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.87" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022102295.1">
        <property type="nucleotide sequence ID" value="XM_022246603.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022102296.1">
        <property type="nucleotide sequence ID" value="XM_022246604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGD1"/>
    <dbReference type="GeneID" id="110985521"/>
    <dbReference type="KEGG" id="aplc:110985521"/>
    <dbReference type="OMA" id="SVSNMQF"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030187">
        <property type="term" value="P:melatonin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0471">Melatonin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022102295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022102296.1"/>
        </source>
    </evidence>
    <sequence length="174" mass="19547" checksum="53091CF6581FDCB1" modified="2022-01-19" version="1">MASSSSTACIRRVSEQEVHAAWLLQAGLASEEETLPEGALQIRQKVAPDLFWGYFENGRLIGFVSGGKTSRSKMAVDAKFVHDPDGCTVCLHTLRVQPDYQGKGIETILIDHLLWYVEENLKGVNKVNLICHDKLVQFYEGLHFRCLGPSDVRLGSKQWFDMEYEVTHESTGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJY1</accession>
    <name>A0A8B7ZJY1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110987484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110987484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105933.1">
        <property type="nucleotide sequence ID" value="XM_022250241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJY1"/>
    <dbReference type="GeneID" id="110987484"/>
    <dbReference type="KEGG" id="aplc:110987484"/>
    <dbReference type="OrthoDB" id="5987060at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034397050" evidence="1">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022105933.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="46843" checksum="3A95A03F2D011C8D" modified="2022-01-19" version="1">MALWVILVIGYLQISIDSIQAVCTRCPLQWTESQGKCYRYFARSLSYTDAVEYCQHLSFPGRIASLATVTTSNELQFMSKFVNDIFKKASALDVPSLLWLNINSMNTTKSLPILHRSLSQESDNIPCEDSHINHDMYRVSGNKNAVSLVPGPEQLDQACAVHLPVESFIDLGYFDESCISDLDSCKSHSVTWSIWLNIDSPSDAKNKLHYFLSSGGQTGLARGIAFLYDARSSQFLFAARSKDLYIRQKYNISKVPLDEWFHLTFIVDSVGTPDMDLKIFVNGELVQVDEEEMSTGAGGQSDTCTRLFLGMSNTCSGDLSLSQYGGSAAYSSLVVFDGLLGPHEICHLYECRSIDKLVNTAKKGQATIGLSLRPVEDAEHPFTIDDKSYTFCDTTTARPTDRSSTSSSCLHHREHPFICQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKM4</accession>
    <name>A0A8B7ZKM4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gamma-glutamyltranspeptidase 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110987616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106178.1">
        <property type="nucleotide sequence ID" value="XM_022250486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKM4"/>
    <dbReference type="GeneID" id="110987616"/>
    <dbReference type="KEGG" id="aplc:110987616"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1199">Hemostasis impairing toxin</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-1202">Platelet aggregation activating toxin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="489"/>
            <end position="491"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00084097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022106178.1"/>
        </source>
    </evidence>
    <sequence length="654" mass="70148" checksum="BE09A2E1FE6D539D" modified="2022-01-19" version="1">MMVGCHDWLKFSSRADKFTASMDDIELGEAQAAEPIDTSRDDDHESAAEDEESCPVRVEVPDLERPTESKKKRRGSEFSLMKRVIVLVVAITIAITFMVVVAVTVSRDGEVVTTGTKMTSGSFRRAAVAADVGICSEMGRDILKQGGGAVDAAITSLLCVGVVNPQSSGLGGGMFMLVYHKDMGKAEALMARERAPAAATANMTRETFGATSIAVPGELSGMWEAHQRYGRLPWGKLFQPVISLAEEGFPVTAHLARALSILSRRVANWTLPEHAGFLTRYANEDGTWKGVGETVYAPKLARTLRAIAMNGVSELINGTTAQRVVQEIQDYGGLITAADLADYKAEWREVNAAPIGQGRSVLTTPSPSGGPVVQFLINVLGNYKISSADFETTERQIKTYHRFVEASKFAFALRSYLGDVEAPEVQEVLDKMRSEEYAKTVFAKIREDAVTFANASGYDALLNTASHSGGTCHISVVDESGNAVSVTSSVNYYFGSMILSNTTGLILNNEMADFDTPSSQPASSANHVAPGKIPLSAMSPVIVVKENGGAELVVGSAGSRAIITTNALVALRSAFTDASLKDIIDDKRIHNQLQPNNVAVYENGFPTDVVDGLVNMGHVVESRTLISVAQAIKRSEDGWTAYSDPRKKGQAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKU9</accession>
    <name>A0A8B7ZKU9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein LOC110986402</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110986402</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor Fz/Smo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103941.1">
        <property type="nucleotide sequence ID" value="XM_022248249.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986402"/>
    <dbReference type="KEGG" id="aplc:110986402"/>
    <dbReference type="OMA" id="NDWIVAR"/>
    <dbReference type="OrthoDB" id="10037534at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
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        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADGR_G7"/>
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        <property type="entry name" value="Frizzled/Smoothened_7TM"/>
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        <property type="entry name" value="GAIN_B"/>
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    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
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    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
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    <dbReference type="InterPro" id="IPR053985">
        <property type="entry name" value="GPR128_GAIN_subdom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
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    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47767">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22259">
        <property type="entry name" value="GPR128_GAIN_subdomA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01330">
        <property type="entry name" value="Frizzled"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
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        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034957077" evidence="13">
        <location>
            <begin position="23"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1310"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1334"/>
            <end position="1358"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1378"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1420"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1468"/>
            <end position="1489"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1495"/>
            <end position="1518"/>
        </location>
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        <location>
            <begin position="51"/>
            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="385"/>
            <end position="461"/>
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        <location>
            <begin position="681"/>
            <end position="777"/>
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        <location>
            <begin position="1082"/>
            <end position="1269"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="15">
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            <begin position="1274"/>
            <end position="1520"/>
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    </feature>
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            <begin position="1538"/>
            <end position="1576"/>
        </location>
    </feature>
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        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
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            <dbReference type="RefSeq" id="XP_022103941.1"/>
        </source>
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    <sequence length="1576" mass="171067" checksum="62F7C2CEE68E3BEB" modified="2022-01-19" version="1">MNRRQVWMLRLAVIVFISLGTGVSVVNPQTTVPPDMPDPATTLAGGSTTTLQGLPDIVIEGCPPVVQPAYVQNSFIQVAISWIEPFSPTLGVDRSTNTPPGTRFGVGVSEVSYTFVDTGGNKAYCVFNVTVQLQCPVITDQPCNNGVCVPRSTSCDGFNDCGDNAPWGSDEGFGECPRNQQCSSASAMLYNACAVPTLWTDAREAVSRSVRGTGNIVFKFTAPSDATDRTYLFRVRLNVTDIIDLQSKELVSPTIFINISLPASVKTTTVRAAVPRGLSAESFVELDLRQPLVVRPSEEIEVTMEFDENILDSPPPFPAESRNRSSVGVRFSTFTAGCDNRACLDAFVTWKTLATFSSRPDVRPCGIPEQNEILYSIYDSCLAPPTFGFVSPSVSSFLEDNVVLICVGHGVFPPSVMWYDSNMNVVASGFGSAALDVTVSFQAQSFTCVLEERISYEETVTVSYWGEECENLYLEVRGFPFQMETPCLSATSLSGSSSGRSPFSPEFSFSIGQAVVAHRFTMDASALNPGNIDEGNPDYGDSGPSAGGVVLPVRLTVSLPLRRKRRGVNTDIYSREFRNLYVPPFGDVTLDLDPPVSLAANSVILFSVTVLQEQRFFESPPPPPARLEVLSCAQGNNSFCDDFLPQWSQKQQDFEESGCPQRRNLQLLSYQICLGSSTAVPKVVTHPRSVDVVLRPSNNEVEEGTAIMTCYIENAVTYEWYKVAPVPGRTLVKSGSTLSFTITQFDNPRVQGSYMCVGKGGTPYDDISQETRPATLTVDGFSMFKVMAAIDRVYTPNLTNPNSTEYTMLWNELRSHLDSALGEFGMLSTNLDLVGFTPGSVVADIILYVGQSNMDDGKLADFIAGAIRDAPSETLTFLPGSIMVLSLVTCLGEEVDGVTFPQTKVGGIAESVEQCPLSTSKAGMPLGTRACAGDVLSPAYWLEPVLVDCTEGDNVNILLGDLSRVNVTSDNVREVAEETVILTSNYTGIDASGIMATADILEKIVIAGNSSVEVAGDIVRVVNNILQVDRETYEDLGEDTSPSRIIRALEDYITALQMSEVAGNLTVVESYVAVSAVLVPQDSLQLGLGFAAVPLSPSAEPQDPLTDEDVVVYYVPSAVPVAEVKASIRLPPEILNFISGGDSVPISFFFYQSTKLFRSPKLRAAARPSDKFSRALGSYVIAATVEGVRVQDLPMEAPVVSAFLPLNVSNPGNTVNGSECVFWDFNLNGGFGDWSTEGCRQVTINNSRTVCHCDHLTSFAVIVDIYGNQDNVVLSIISKIGCAVSLVALIITIITYLAVKKLRTKRPQQILVSFCFALAGLYLVFLVGIEATSPQAGCIIVAVLIHYFTLASIAWMAVEATNMYLLFVKILNANVSHFLIKASIAAWGLPLLVVIIILAVDHTNYLSTNYCFLRPGNAFYFGQILLIGLVLLFNFIIFTLVMRQLTCARKGINSTTDRSKHQETMRRLQNAVAISVLLGLTWVFGLLSLVQTANFAFQVLFCVFNSLQGLMIFLLFCVRQQEVRQAWVDFARGRCGKDRAADYSKGAGTRSQDRANTGEQGTLPLTHRSTDSTATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLR2</accession>
    <name>A0A8B7ZLR2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Damage-specific DNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 21" type="primary">LOC110987715</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DDB1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106399.1">
        <property type="nucleotide sequence ID" value="XM_022250707.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106400.1">
        <property type="nucleotide sequence ID" value="XM_022250708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLR2"/>
    <dbReference type="GeneID" id="110987715"/>
    <dbReference type="KEGG" id="aplc:110987715"/>
    <dbReference type="CTD" id="1642"/>
    <dbReference type="OMA" id="HQDFLMR"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.910:FF:000001">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000070">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002576">
        <property type="entry name" value="DNA damage-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="17">
        <location>
            <begin position="51"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="18">
        <location>
            <begin position="433"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="16">
        <location>
            <begin position="829"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="795"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="795"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022106399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022106400.1"/>
        </source>
    </evidence>
    <sequence length="1178" mass="131408" checksum="7CFB116DA73C3CFE" modified="2022-01-19" version="1">MVNSDIIFSLKRFNIHRAHDSSFLDIEVHLKPYFILKMAYNYVVTAHKPTAVNACVTGNFTSPDDLNLIVAKNTRLEIYVVTPEGLRPVKEIGINGRIEVMELFKPQGQNKSLLFILTARYNACILEYVKDGENEEIVTKAHGNVQDRIGRPSETGLIGIVDPECRVIGLRLYDGLFKVVPLDRDNKELKAFNIRLEELNVIDVKFLHGCQVPTIVFVHQDPHGRHVKTYEINLREKEFNKGPWKQDNVETEASMVVAVPKPCGGALIIGQESITYHNGDKYVAIAPPSIKASTLVCHGRLDSDGSRYLLGDMAGRLFLLHLEKEESMDGSVIVKDLKVELLGETSIAESLTYLDNGVIFIGSRLGDSQLVRLTVDPDEHGCYVQPMETFTNLGPIVDMAVVDLDRQGQGQLVTCSGSYKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRVDQGSQYDDTLVLSFVGQTRVLMLNGEEVEETEMPGIDGNQQTFYCGNVYSNQLIQITAASVRLVNAVTKRMVSEWRSPSSKNISVASCNTQQAVCAVGRDIFYLKIHEGELRQISTVTMEHEVACLDITPLTEGSDMAELCAVGLWTDISARILKIPSLESMHVEMLGGEIIPRSILLSVFEGQCYVLCALGDGSLFYFQLNTETGFMRDRKKVILGTQPTVLKTFKSHATVNVFACSDRPTVIYSSNHKLVFSNVNLKEVSYMCPLNSEGYQDSLALANDTTLMIGTIDEIQKLHIRTVPLGESPHRIAYQEATQTFGVITTRTELKDATGLGTMPVRQSASTTALNMSSSTNSKSMPGQSGSEGSHFGEEIELHSLLIIDQHTFEVLHAHHFVPYEYATSIVSSKLGNDPTTYYIVGTAMVYPDEAEPKKGRIVVFQYSDGKLQEVTEKEIKGAAYSMLEFNGKLLTSINSVVRLFEWTSERELRVECSHYNNILALHLKTKGDFVLVGDLMRSVTLLAYKPMEGCLEEIARDYNPNWMSAVEILDDDTFLGAENSFNLFTCQKDSAATTDEERQHLQEVGLFHFGEFINVFRHGSLVMQNIGESTIPTHGSVLFGTVNGTVGLVTQLSEEFYHFLMEVQNKLTRVIKSVGKIDHTFWRSFYTDRKTETAENFIDGDLIESFLDLSRDKMEEVVQGLQISDGDMKRDATVSDIIKIVEELTRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMK0</accession>
    <name>A0A8B7ZMK0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Organic cation transporter protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC110987584</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106118.1">
        <property type="nucleotide sequence ID" value="XM_022250426.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106119.1">
        <property type="nucleotide sequence ID" value="XM_022250427.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106120.1">
        <property type="nucleotide sequence ID" value="XM_022250428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMK0"/>
    <dbReference type="GeneID" id="110987584"/>
    <dbReference type="KEGG" id="aplc:110987584"/>
    <dbReference type="OMA" id="IMMEIAV"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022106118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022106119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022106120.1"/>
        </source>
    </evidence>
    <sequence length="144" mass="15472" checksum="4D5F72F11371A568" modified="2022-01-19" version="1">MIGKFAISGAFNIIYIYSAELFPTPVRSMGVGMSSMSARLSGVIAPVILILGNYWEPVPLIVFGGCSLLAGALALLLPETLNHSLLETVQEGEEFGKGQGFGLKKLFRRPNSPEGSSSADDSKEEPYRQILTYDEINAGESSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNN4</accession>
    <name>A0A8B7ZNN4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110988201</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 14 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107208.1">
        <property type="nucleotide sequence ID" value="XM_022251516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNN4"/>
    <dbReference type="GeneID" id="110988201"/>
    <dbReference type="KEGG" id="aplc:110988201"/>
    <dbReference type="OMA" id="TICINIL"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 14 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19297:SF181">
        <property type="entry name" value="PROTEIN XYLOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022107208.1"/>
        </source>
    </evidence>
    <sequence length="487" mass="56224" checksum="0E221104380A4B71" modified="2022-01-19" version="1">MVCSVRQRFFGWFAALCTFFVVVQMMLIIKQQRIDILGGQTNKDASPLDPASGQHNKTVRRNEAQKSAHRGRGKLPQIADKFLIDPSPSNNSLWPFHRRWDTNCSAIFAGDTRVIRPTYHRLKEERQAHNGSILVPEDHEVQTWTRYCESYKRLRRYPSSPRSKEEAEFPVAYIIVVHKEAAQVERLLRAIYQPQNLYCIHPDTKSSSDFHRAIRGLVGCFKNVFVASKTEDVQFAGFTRLLADINCMRDLTGPRGDEYRWNYVINLCGQDFPLKTNLEIVRQLKAYKGHNDITGVLAPPHYIGRTSYHHVIENKQVKRTSRAKAPAPHALKIHFGNAYYAATRHFVDYVLTSPAGTDLLRWSNDTYSPDEHYWVTLQRAPGTPGGYPHPTWDGNVRFMKWWGDDMKLPWCRGMYVRFQCIFGVGYLEYLATQPHLFANKFYYSYDPVAIQCLEEALISRTQNPALSDRLPNFPVTNLVWQNHTALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP32</accession>
    <name>A0A8B7ZP32_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Uncharacterized protein LOC110988294 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5 6" type="primary">LOC110988294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107348.1">
        <property type="nucleotide sequence ID" value="XM_022251656.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107349.1">
        <property type="nucleotide sequence ID" value="XM_022251657.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107350.1">
        <property type="nucleotide sequence ID" value="XM_022251658.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107351.1">
        <property type="nucleotide sequence ID" value="XM_022251659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP32"/>
    <dbReference type="GeneID" id="110988294"/>
    <dbReference type="KEGG" id="aplc:110988294"/>
    <dbReference type="OrthoDB" id="6727911at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773:SF19">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10773">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022107348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022107350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022107351.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="35130" checksum="0D4A070BC8209B1F" modified="2022-01-19" version="1">MDVLVKWSDGSQNIVYSEHLKYKPPLNVNKAVKMKWGRVWWRGRVLDFEESTENDEDTSDSTDSDDVPISTRLSTTKSTGCYLATTCTNGNLSPRFLMETEVAASCFSPHTPAPCNSPRPEAAARCSESSCTPEDATSISTTPAPCSSGSSECVVSNSVLATATTLEDNIPEATPGHSSRTVSPVDAAPISNPHRKPAESCSSSSYTPDDTANCSISASEVVLGSNSSFLTEGAPASSSGSTCTSPGIINAHCSPNGLMGAVSSSADNTAVQDNGRVQTCSNFSCHKEIFAACSICHCLVCFEHFVNSDSRATHNLLFDIFEGHAGIKACTNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPU8</accession>
    <name>A0A8B7ZPU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ficolin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107429.1">
        <property type="nucleotide sequence ID" value="XM_022251737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPU8"/>
    <dbReference type="GeneID" id="110988341"/>
    <dbReference type="KEGG" id="aplc:110988341"/>
    <dbReference type="OMA" id="SINWHAF"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020837">
        <property type="entry name" value="Fibrinogen_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00514">
        <property type="entry name" value="FIBRINOGEN_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107429.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20537" checksum="0A18D77A4AD19026" modified="2022-01-19" version="1">MFCFETSVFQRRQDGSVDFYRDWVSYRQGFGDLNGEFWLGNDNLHRLTAQGAYRLRVDLEDFENNTAYAKYDMFRVADGSDNYRFTVQGFSGTAGDSLSSYSNSPFTTKDRDNDSYGPNCAVAFTGAWWYTSCHSSNLNGLYLSGETDVYAKGVVWRYWKGYYYSLKRTEMKIKAANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQD6</accession>
    <name>A0A8B7ZQD6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ninjurin-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ninjurin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107277.1">
        <property type="nucleotide sequence ID" value="XM_022251585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQD6"/>
    <dbReference type="GeneID" id="110988249"/>
    <dbReference type="KEGG" id="aplc:110988249"/>
    <dbReference type="OMA" id="IGHEFRF"/>
    <dbReference type="OrthoDB" id="6114058at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007007">
        <property type="entry name" value="Ninjurin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316:SF17">
        <property type="entry name" value="NINJURIN C, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12316">
        <property type="entry name" value="NINJURIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04923">
        <property type="entry name" value="Ninjurin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022107277.1"/>
        </source>
    </evidence>
    <sequence length="250" mass="27292" checksum="056AF8938EDDFC0E" modified="2022-01-19" version="1">MSQSCLPSNFVRQGPDRKAVADPSTFSGSCDDPLRGGRDNTSSSTSNLVDNNAAESHPLTTDTCPTSTSNITLTAPPVHRQSSTGRLARSLQLRTISDEAQSMSMIVHPGSVRRNYEPVHQEMENSTSVPTTPVPSNPAPRAIDYNIYATKKTVSQGLLAVALLMANASQLKSLVSIGHEFRFFRFVTALIIISISLQLVTGVFLLLLGRDNLNDVYRQHRLDRLNNWTTGFVFTIVVINVFIAAFGLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSZ7</accession>
    <name>A0A8B7ZSZ7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-conjugating enzyme E2 Z</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin carrier protein Z</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin-protein ligase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110988719</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022108192.1">
        <property type="nucleotide sequence ID" value="XM_022252500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSZ7"/>
    <dbReference type="GeneID" id="110988719"/>
    <dbReference type="KEGG" id="aplc:110988719"/>
    <dbReference type="CTD" id="65264"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23809">
        <property type="entry name" value="UBCc_UBE2Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000046">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF26">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2 Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="39"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022108192.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33558" checksum="B805FF31394ED7A5" modified="2022-01-19" version="1">MAEAAASNVSEVTLQQSSSTASWDPSASRDWDDQKPTQQCILRIKRDIMNIYAEPPPGMCVVPEEDITKVSVHALITGPFDTPYEGGFFHFLIRFPPDYPIRPPRVKLVTTGEGKVRFNPNLYRNGKVCLSILGTWTGPAWSPAQSLSSVLISIQSLMNDKPYHNEPGFEQERQPGDCERYNDCIRHETIRVAVCDMLERENPVMPKTLGEVMKKSFPEFYEYYMSTVTEKLHLTGLSMQDPYGERRGKFQYNTLKLSLEKIKQRLEAEEAINKASDADSSGTSDNEMDTSTPCSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU01</accession>
    <name>A0A8B7ZU01_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat-containing protein 25-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988909</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108557.1">
        <property type="nucleotide sequence ID" value="XM_022252865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZU01"/>
    <dbReference type="GeneID" id="110988909"/>
    <dbReference type="KEGG" id="aplc:110988909"/>
    <dbReference type="CTD" id="79446"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053053">
        <property type="entry name" value="WD_repeat_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44566">
        <property type="entry name" value="TRANSDUCIN/WD40 REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44566:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="218"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="457"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="487"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108557.1"/>
        </source>
    </evidence>
    <sequence length="520" mass="58243" checksum="09A1D5119BB54AAA" modified="2022-01-19" version="1">MDALKAYHSSDSDDETVPHPNKPPNDVETFDINKPLDTAAKLPPPYLDFNFSKRQHGGESSDEAVCHPLLPWSGPPRRNRKHDLWKQQVSAGNQTSAVNSGHMACTSVAETEPSMHNLSLASSAGAQHKAGERMFQGKSDVTWHTSATSKRQAVIQPYVPKRLRPSPSCACHADPQSPQGEPTLESLKETMYITQPVIACQMERHLTSKLPKHKTFQFHSHTGPVTCIRWCRPQFSHLLLSSSMDKTIRIWNGIGTVGCCLQIFNCHRGAVKDAQFTEGGRRVLSCGFDKTARLCDVDSGKELQVFEHPSYATCIKTKRDDPSIFITGTYNSSIFCWDIRTGQNEQEYRGKLGQILDLEFLPGCEEFVSSCDVVSRDSANRTIMVWDLRSTAVVSNQLYHEKYTCPCLRRHPSDSVFVAQSTANYIALFSTVRPYKMNKFKRYEGHQLEGYRIGCDFSPDGTLLNTGSCDGRVYVYDYRTSRILKTLQCHAGPCTDVAWHPVLPGVMASCSWDGAVHVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV18</accession>
    <name>A0A8B7ZV18_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110988303</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 12"/>
    <dbReference type="RefSeq" id="XP_022107361.1">
        <property type="nucleotide sequence ID" value="XM_022251669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV18"/>
    <dbReference type="GeneID" id="110988303"/>
    <dbReference type="KEGG" id="aplc:110988303"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07855">
        <property type="entry name" value="STKc_ERK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000028">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034528096" description="Mitogen-activated protein kinase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="51"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="435"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="632"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="765"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="880"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1021"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="685"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="791"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="881"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1021"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022107361.1"/>
        </source>
    </evidence>
    <sequence length="1162" mass="127988" checksum="0BDF8F1FE6D3E71F" modified="2022-01-19" version="1">MFTHLFPALWFTLQLFLRPQRSAMQQAATKNLRAFKTKCLDVYFDLDNSEYRAIQNIGTGAYGVVCSAVHKKSSEKVAIKKIPNAFEELTTAKRTYRELKIMRHFRHENVIGIREILMPRESLSDFRDVYVVLDLMESDLHHIIHSQQAVSMEHIRYFLYQILRGLKYIHSANVVHRDLKPSNLLVNENCELKIGDFGMARGLSGSADSKRKMFMTVYVATRWYRAPELLFSNDDYSYAVDMWSVGCIFAEMLGRKQIFPGKNPMHQLSLIIEVLGMPPDSLLRSTNSDQIYNFFHRNFGEKQSTNLREKYPNLDDDGRDLLSKMLVFNPSERISVKEALSHPFLAKYHDPDDEPDCFPVFDFSFEQEDLTKQQIRQNVGKMILKYQRTKLFAGKKLPGSLSIVKTPTAIPATSTACQETKSAILQSAAAPVFPANPLPVSNPPSTDQSSDAKEPPQKGIFKVPSLPTGEKKLLPAEPKPPPKEADGEPDALSVSAVPTLTVTNDVDMKSASRSAQNTADSSMDRLAQGASTYATLTASSTNTISDDVEMKSAKGEQNQLVTESSIGPCVSEPVDVDMKSARQGEAGVVSISSQVQSTLNISKQPECMQSTGQKTISQDTKELIKAALRQSALKNKMRKDSEAEKGGGKIPVTALSRQREREQKRRQKLRRSLERQKRGKGKGKKATENSEEDKHQLLTNEDRNLLERWNKMLSKKKEMEESTGETDRADKESSRPGPDLGKVSQDKSLLTHRCVGSDAALATLSADASKSTQGSPNCSSLAEPQVGEPLSSMTSTVSSLQQKQKTAQTGPELCEKIPASGAVEPASMLSQQQVSSLGSTPPSVIFTFPMATQAQQNSLSGTIKFLPTSVNSFGVNDPQLFLSQPSSQPMNTNPNHSFLPQSDVESSNGTTARPIRDQQVPIAASSTSKPPASTADSAIAQLLERYPTAVSSSFSPTGVKGDSNSGFQQYRTRHYSDRETPSPPHNIQQSPPAYEDALKKKLINYKSPTGNQHSYLYKQSSQYHNASKQSPVATADPQATQPNPSTDPTPPDLAQVIRQLSKSAMEDSLPPVLQVTPKGDGAGYGLSMDLEDWFEGSLGSPPGACKLDSGPLSASLLSDWLEVRNMNMDDMMAVQQELGLMSPFNMLDIPGLVVSPKDKDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV70</accession>
    <name>A0A8B7ZV70_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sperm-associated antigen 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Protein PF16 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110989320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with SPAG16 and SPAG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022109314.1">
        <property type="nucleotide sequence ID" value="XM_022253622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV70"/>
    <dbReference type="GeneID" id="110989320"/>
    <dbReference type="KEGG" id="aplc:110989320"/>
    <dbReference type="OMA" id="CECIEQS"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097228">
        <property type="term" value="C:sperm principal piece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000196">
        <property type="entry name" value="Sperm associated antigen 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000129">
        <property type="entry name" value="sperm-associated antigen 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314:SF0">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23314">
        <property type="entry name" value="SPERM-ASSOCIATED ANTIGEN 6 ARMADILLO REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022109314.1"/>
        </source>
    </evidence>
    <sequence length="508" mass="55182" checksum="61A3DD7720000C5E" modified="2022-01-19" version="1">MSSRQVLQVFEQYQKARTTFVQTIAELASRSQNIELLQNAGVMSLLRPLLLDVVPTIQQTAALALGRLANYNEDLAEAVVKGDILPQLVYSLAEQNRFYKKAAAFVLRAVAKHSPELAQSVVDCGALDALVICLEEFDPSVKESAAWALGYIARHNAELAQSVVDAGAVPLLVLGIQEPELCLKRIAASALSDICKHSPELAQTVVDAGAIAHLAQMILNQDQKLKRQVFSALSQISKHSVDLAEMVVEAEIFPAVLTCLKDKDEYVRKNVATLIREIAKHTPELSQLIVNAGGVAAVVDYVGESEGNVRLPGVMMLGYVAAHSENLAMAVIVSKGVTQLAIALAEEPQDHIKAATAWALGQIGRHTPEHAKAVAVANVLPRLLQCYLRADASEDLQTKAKKALKNILQKCVHLPALEPLLHDAPANILKHVVGQFSKVLPHDAAARRLFVTSGGLKKVQEIKAEPGSALHEYINTINNCFPEEIVRYYSPGYSEALLERVEQYQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZWN0</accession>
    <name>A0A8B7ZWN0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc finger CCCH-type with G patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110988580</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107941.1">
        <property type="nucleotide sequence ID" value="XM_022252249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZWN0"/>
    <dbReference type="GeneID" id="110988580"/>
    <dbReference type="KEGG" id="aplc:110988580"/>
    <dbReference type="CTD" id="84619"/>
    <dbReference type="OMA" id="QYTRGIG"/>
    <dbReference type="OrthoDB" id="5842926at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20384">
        <property type="entry name" value="Tudor_ZGPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297:SF1">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="16">
        <location>
            <begin position="280"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="15">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="325"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="456"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="540"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022107941.1"/>
        </source>
    </evidence>
    <sequence length="611" mass="68372" checksum="77437BCA191919F2" modified="2022-01-19" version="1">MSCGLYLTQIINFKVNTHHNSQIHYTLMDEETLQTSISAYKQQLQQVETVLLSAGAEGQTELLQLREDLQQVIQLTEESLLSLKKSKLLSLVDGTSSAETSSSFVNPASSSGDAQVQQGHSSASGSSSGKFEEEYAAFQAALADEEETVAPPQSSNASSSTGSISQWSKEITNAEVGEDDSGGEEEDDICGTKCSVDYMEEWGGRQRHNAVVLCVEPRNSLKEEASLRVLFCNPTSKSMRPCPYFLEGTCRFTTEDCRFSHGYVVKLSELHAFKEPDFSLLKLEAPCLARYSDGIWYPASIQHIDQDKHQVAVQFESYGTTETLDIESILPSEQREESSPSLSSSSDDDYDNEEDKANLPSTSYSRSVEQQEEKEEDEGDFPRIAWRPSGDGIPLGEWEAHTRGIGSMLMAKMGYEFGKGLGRNGEGRVEPVEAVIIPQGKSLDKCMELREMKKLGIVGKPKKKKGKGKGHHHSQGGSSSSSGQHREKENVFDFINRKLGGKKTKITELIQQNSNNRNFQGKDPSKDKQEKPGRKLNIQLVRTEEDIRSTEKQLMRLQESLQRNQRDKLTASKIKEKIDATERLLQNLKSYESKIKRQQNNREEHRKLTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZX12</accession>
    <name>A0A8B7ZX12_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="16 17">Lariat debranching enzyme A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC110989773</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110088.1">
        <property type="nucleotide sequence ID" value="XM_022254396.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110094.1">
        <property type="nucleotide sequence ID" value="XM_022254402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZX12"/>
    <dbReference type="GeneID" id="110989773"/>
    <dbReference type="KEGG" id="aplc:110989773"/>
    <dbReference type="CTD" id="51163"/>
    <dbReference type="OMA" id="CARFEVS"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="14">
        <location>
            <begin position="235"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="530"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022110088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022110094.1"/>
        </source>
    </evidence>
    <sequence length="584" mass="65261" checksum="0A2FD05B616E35A7" modified="2022-01-19" version="1">MKIAVEGCCHGELEKIYATIQHLEEKEGIKVDLLLCCGDFQAVRNESDMECMAVPKKYRTMNSFYKYYSGEKKAPILTLFIGGNHEASNYLGELAYGGWVAPNVYYMGYASVVNYGGIRIGGISGIFKQRDFRKGHFEIPPYSQDTVRSAYHTRGLEVFRLKQIAQPIDIMMSHDWPRGIYHHGNTEQLLKKKSRFRDEVHSNTLGSPCHEELLHHLKPTYWFAAHLHVKFAAVVSHGSASGEDKTTKFLALDKCLPRRNFLQVLDIPHKTDAPWELTYDTEWLAILQSTKLLLTTNDRVVYMPSKQYNSKWDYIVSLEQLSAIREIFQDNLKVPLSFTQTVRVHDPANPVKNPTQPKAAVNPQTALFCSKLSITDPFAAIMESTGQSIPATPSPLRTTSQRDVTVNTDEDSAIYDSFTVPCDTSIEEGSEEDAANSSSNPAEISLDDNEDEEEEVVRTGLRDRSVDRPLLIDLPTPLGRLGTSLDEKMSHEISLDVSNVSSTPLKDSIIRDATAETPVLTTGKMKRRNLDIYSSQEEDSATDETRTACLSSAGESSSTESGSSGGKKLKRRNQSMYTSNEDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZY69</accession>
    <name>A0A8B7ZY69_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110989947</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022110364.1">
        <property type="nucleotide sequence ID" value="XM_022254672.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110365.1">
        <property type="nucleotide sequence ID" value="XM_022254673.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989947"/>
    <dbReference type="KEGG" id="aplc:110989947"/>
    <dbReference type="OMA" id="PLLRWYI"/>
    <dbReference type="OrthoDB" id="5988713at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.960.10">
        <property type="entry name" value="VSR Endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004868">
        <property type="entry name" value="DNA-dir_DNA_pol_B_mt/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33206:SF1">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33206">
        <property type="entry name" value="PROTEIN CBG10425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03175">
        <property type="entry name" value="DNA_pol_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022110364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022110365.1"/>
        </source>
    </evidence>
    <sequence length="1621" mass="187398" checksum="6A231C53BEE0BAA6" modified="2022-01-19" version="1">MKRVLGVHECLVCNKTFTRRDALRRHKTTHTTVKSVSCPECGASFRRTDNMKRHRCSQHQQRTDPARPTSSATTAPHNRSGTSRPEPPVQPTDGAHHQPDDQPGCSHWPDPATLAPAHPIANSNQQSMTAPPPATAPAPAPTSDNPRKCPGCGKAFPLIESMHRHYARVHTGQRPTPPSPQPIDDRFEEDPLVYPEGDEDDLGLTDIIRDNWESIRAFQVTGHPVEDIYNIRVVQSSKNHRNTAQKILSNLTDHEQLINVSFGAIVRHDETGELRFFDADSVRFFPTPVSFDSHFLEQFEDEVIADFVRGHFKDWSLVALTNIRLFVRHAPDPLRDDPEEFPAEMEVDDDEVGRVYRNNWAAIRTHHRIGRVIQDIYNIRMDRPEASFMRIMNGIFKKLTCRVKVNLSCGFILRHNETGELRYFHPSHNNAKLFSIPFTIGSQGDMDSLIEALEALDVVEYARQQRPDTKWTVVVLTNLAVYVNKMPQFYIGAPPQSLPDFVKNNRGLHNLTHNPNNWQRYNDNLCFFRCLALNRGAPLRGLERTTQDLAETFQRSTGRQISRGVTMEDLSEAERIFEVTIQVYSLTQVDNGDDRQQTRVHLIRRSHRRYAANLHLHLFQEHFSYIFDLNKFSQTYECEKCRMIFNRSSNLQRHVPTCNVNVKHRFPGGVYNLPDTIFDKLEEAGIDVEENLKYYPYRATYDYECYFDNVDQNGGQEKLTWCNRHELLSVSVASNVPNFDSARCFVSDGDPASLVGRMVNYLHEISEAAFINLTEKFEDVFSRIQELVELQQNQEGKQPRARDDTAPTKKVAAEKLREELEHYLGELPVIGFNSSKYDLNVIKKHLYQRLKEAGDPVEMVIKRGGSYMALKTKKLKFLDISNYLAPGYSYEKFLKAYDCAHDKGFFPYEYMTNLNKLHETALPPHEAFFSTLKETNITEEDYRYCQQVWRDEGMTTLRDLLVWYNNLDVLPFLDAIQKMFNFYKERRMDMFKTAISVPGLSLQYLFLTLADNISFSLIDEPNKDLYYLLKKNIVGGPSIVFHRYHERGKTQIRGGPQQCANIVGFDANALYLWSLMQPMPVGTFIRRREEDNFKPVPSHKWGAKASEWLEWVAHTDGLFIRHQLNRGEKRVGSRAIPVDGFCKENNTVYQFHGCFWHGHRCHLNPQEFNPVKNLPRAELRRQTEEISTYIRAQGHSLVEMWECEWTRLQQEDANAADFVRSRRLPHQHKTLNQRGILDAVVNEELFGLVECDIEVPAQLRETFAEMPPIFKNVEISREDIGDHMREYAEREGLMKSPRRSLIGSMFGRRILLASPLLRWYIQHGLHVTHIYQFIQYGQAACFQPFGEAVSNARRDGDVDPSKGIIADTMKLLGNSAYGKTVTNQEKHLQVQVAHSDEAASRLINLPNFRALHTLDEKLYEVELNKKAIRLGLPLQIGFFVYQYAKLRMLQFYFDFLLKFIDPADFQLCEMDTDSAYMAISAQRLEDIIKPHLRDQFQREKSSWFPRNDTPTHRAFDKRTPGLFKVEWEGDGIVALCSKTYYCFGDQDKVSCKGINKRTNNISKRRYLDTLQTQQAGEGVNRGFRMREDGMHTYQQVKTAFTYLYPKRKVAPDGVTTTYLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYF4</accession>
    <name>A0A8B7ZYF4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Putative hydroxypyruvate isomerase</fullName>
            <ecNumber evidence="4 7">5.3.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110989589</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate</text>
            <dbReference type="Rhea" id="RHEA:11952"/>
            <dbReference type="ChEBI" id="CHEBI:17180"/>
            <dbReference type="ChEBI" id="CHEBI:57978"/>
            <dbReference type="EC" id="5.3.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the hyi family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.22" evidence="4 7"/>
    <dbReference type="RefSeq" id="XP_022109780.1">
        <property type="nucleotide sequence ID" value="XM_022254088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYF4"/>
    <dbReference type="GeneID" id="110989589"/>
    <dbReference type="KEGG" id="aplc:110989589"/>
    <dbReference type="CTD" id="81888"/>
    <dbReference type="OMA" id="CEYRPRA"/>
    <dbReference type="OrthoDB" id="4214675at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008903">
        <property type="term" value="F:hydroxypyruvate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046487">
        <property type="term" value="P:glyoxylate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000007">
        <property type="entry name" value="Hydroxypyruvate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026040">
        <property type="entry name" value="HyI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050417">
        <property type="entry name" value="Sugar_Epim/Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489:SF6">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43489">
        <property type="entry name" value="ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006241">
        <property type="entry name" value="HyI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="9">
        <location>
            <begin position="49"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR006241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022109780.1"/>
        </source>
    </evidence>
    <sequence length="293" mass="33221" checksum="D99126A12B21E4C1" modified="2022-01-19" version="1">MFLFLSNIHLSLVKRFISVSRRSKMPLKFAANLSMLFKEIPDLAERYSAAKRAGFQAVEVSFPYDSPVEKLVEVKEREGLEQVLINSFPGDMKAGDLGLAAVPGREKEFQDSLELSIKYCTLLHCKRMHVMAGVTPDCTEDDRPAVHRKMEETFISNLKYAADRLSQEGILTLIEPINTVVSKPGYFLSRQDQGVDIIKKVGHPNLKLQMDLFHVQMMQGNITNTIKEFLPYIGHVQIAQAPHRNEPSAEGEVNYDFIFAFLESLGYDGWIGAEYNAADGKTQNSLQWLQKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYK5</accession>
    <name>A0A8B7ZYK5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Leucine-rich repeat-containing protein 27-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9" type="primary">LOC110988951</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108654.1">
        <property type="nucleotide sequence ID" value="XM_022252962.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108655.1">
        <property type="nucleotide sequence ID" value="XM_022252963.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108656.1">
        <property type="nucleotide sequence ID" value="XM_022252964.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108657.1">
        <property type="nucleotide sequence ID" value="XM_022252965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYK5"/>
    <dbReference type="GeneID" id="110988951"/>
    <dbReference type="KEGG" id="aplc:110988951"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF35">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="318"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022108654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022108655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022108656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022108657.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="58094" checksum="166CAE70E54D7BD5" modified="2022-01-19" version="1">MAGDDSEDSSSVTAAATREDVLNVIAVASALGAITLDISRKGLTHIPNEIYLLQHVEYVYLEGNAISHVPSELFDKLCNMKWLDLRNNQVQELPASVGEHRCLKTLLLEGNQLKELPCELGFVKTLTGLNLQRNPLEFPPPKVLERGVKEIQHYLRDAHGIRDPRLIAADIQLEDLHLSDSVRNSSEGDDDYHGNLSSEDAVSRQSRKLKSASHQSIQSVESNEDLEFPRPTSVSLHRHMTYEEYRQLQYEKFKRAGALGVLGRENEKDASLMLSDVHVGITGRQVAGRKIYRRKKKKKGQRMKTPPWIDPLESRMAEEKQLAKLRELQQKQALIEQRRKDQQLLEDWRSETREMQRKHYIRAIKNAQQGMPWKYKDFTDPLKTPYDTDPNYMKILSKEERIKQEVKNKHEAIKQRTDPEAAQKLEKARAERDRQLMDRIKQHNLKVQERKQRPRGNPREEMEAAQRDLKMASDLQREVNHRRLELEYRFRAFTGDASPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZD3</accession>
    <name>A0A8B7ZZD3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110990193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110789.1">
        <property type="nucleotide sequence ID" value="XM_022255097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZD3"/>
    <dbReference type="GeneID" id="110990193"/>
    <dbReference type="KEGG" id="aplc:110990193"/>
    <dbReference type="OMA" id="YCAFVMF"/>
    <dbReference type="OrthoDB" id="1899781at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042418">
        <property type="entry name" value="TXNDC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14684:SF2">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="245"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022110789.1"/>
        </source>
    </evidence>
    <sequence length="415" mass="47452" checksum="9A36A7AE4AD5A915" modified="2022-01-19" version="1">MSKCVMRKQENKMAIPLTKSRRCMHFSVVFLVKLSMFTYLILDIVHSAEDKEISQEKGTDLFTSENHIQGRGSPDSASPDLMTSAEQENEEMFENILEKTWQQIGDLHGGIRPEVKMAKEGTVVTGKEYKRSRPDSSTPMDYIQLLASYMRPEVFHKFIEGLNKTLDAHKQYSHPEFTYVNTTEIHADGSQQHKVKYPCMHRPTGNRTLHVKIVNNTEMMELVSSVYHPPSQDNSSSVLGGYCAFVMFYAPWCKFSAKAAPAFNAIGRAFPDLEVLAIDAFQYNSLNTRFGIVAVPNVLLFHNSKPVMRFNYSQRTFDVFSGFIRNFTGLEPNSSVQVSEEDYLGPVPSVATEESDYALWLSWLFLITVLLWFLQQQVGSIIMDRIRVFAIYARQVWRTGELYDQVGVLVHEHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1R2</accession>
    <name>A0A8B8A1R2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990902</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111678.1">
        <property type="nucleotide sequence ID" value="XM_022255986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1R2"/>
    <dbReference type="GeneID" id="110990902"/>
    <dbReference type="KEGG" id="aplc:110990902"/>
    <dbReference type="OrthoDB" id="5952652at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111678.1"/>
        </source>
    </evidence>
    <sequence length="445" mass="51279" checksum="039D087FE9A1E98F" modified="2022-01-19" version="1">MSISKSHDLFSAAEMARKYFVVCLMIALSYLVCCKFWIMPSQRLVPRPQLIRPSPHNRQMAATKNGLGSGLSFTKSKNLTLTIRMAAVPKIVSLLYCVLLRSAALFWSPRYGPISLILDAESERDHQLAAKLRRHEQALGMQFDISYEPLPADADTIFHSTMRSMGYCRQLWSSFFTDMYVSADVVAWIDTDNMFFSPVTPENIFNGGRIRVLGVPLVGTRWERLVSDSVKTAIGWKTIARFPNFPIYLWRDTITNCRNHILKTLNVSRFGDAFVKIYPQGKKICPSDLILTYAYYFEHNRYSWHIDVKKQSLAKYNQHQVPAGFEIRGNETEPGFLQVATHKKYNFMFQGFCIAKRYVGTLPANCKMYENTTNFQHFSAIYNHLKTWCAPGRGRAKCARLIEAHYQNFAGYYRSRLMDLDLQRVLAVEEEAKKENISCSKIFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A253</accession>
    <name>A0A8B8A253_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110990381</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111050.1">
        <property type="nucleotide sequence ID" value="XM_022255358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A253"/>
    <dbReference type="GeneID" id="110990381"/>
    <dbReference type="KEGG" id="aplc:110990381"/>
    <dbReference type="OMA" id="REPAIYS"/>
    <dbReference type="OrthoDB" id="10110498at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111050.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37456" checksum="DBB2D92402042813" modified="2022-01-19" version="1">MCLPDKYGRPSPLCLIPLALLCMILGGGLVGSWVACYYRCEDGTNVDYNYYAAVWTGGLAVFSGLLQLFLACFWNKILKYFLVVYNVVLILCCLLSAALYGYRTYLENEATPPGAASPSVGVILSALQAALAVFILIFVMVWNCIIGCASLDAETGDYYDDRRARTKSRDRKRPQQIRGPYEDDFFNREPAIYSAQSHYQERPQEVSYGQMDRTNTGTSGYIIPRASVRGALPENGYHSNGGTMVVDGREQLRAGWGEREEPRSFYTGSGRYDQRSSTAPRKTGHALQNGGTFPNGTGGGRVRDLGSRAGELTSNRYGRGVSLMQMHGVASTSNITEGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2N3</accession>
    <name>A0A8B8A2N3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110990499</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110990499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111225.1">
        <property type="nucleotide sequence ID" value="XM_022255533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2N3"/>
    <dbReference type="GeneID" id="110990499"/>
    <dbReference type="KEGG" id="aplc:110990499"/>
    <dbReference type="OMA" id="IVCHFYL"/>
    <dbReference type="OrthoDB" id="5818871at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38553:SF1">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38553">
        <property type="entry name" value="PROTEIN CBG19621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022111225.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41405" checksum="5BF3B3EDCA9DF2A5" modified="2022-01-19" version="1">MYSTVVPADCMSPDEVINSSQPDVVRQGCFCDFDVIACTRNGILSLFAGILTILCIYKIVRLHQAPQQYYHQLLVFYCATVECLIVIVHWVYIHYPQLELAAEYMKMLQLLIVCHFYLSRSVRLLRRDHLSMKLVLPALIAFFAYFSVVAVIAIVMSKDTTMECFDPYWVMMSAVEFFLTQLFLLAGILITKKMNEVTTLESARRQQKRNLWSIIIAFELSSLTTMLFDAVMLILNPQNASCADIYNRSQIVYSITYLFLMLFKIVVPIVTLLAVFHPVSRYTDSNQEDFLTSDTQYGAFQARFASPGSYRRLYQPGTEDHGIPWVPPSQYASPARRTQSFPKLPSIQEEHEPTSLSLPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A2R2</accession>
    <name>A0A8B8A2R2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110990883</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110990883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111657.1">
        <property type="nucleotide sequence ID" value="XM_022255965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A2R2"/>
    <dbReference type="GeneID" id="110990883"/>
    <dbReference type="KEGG" id="aplc:110990883"/>
    <dbReference type="OMA" id="SHDHILN"/>
    <dbReference type="OrthoDB" id="6130210at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981:SF1">
        <property type="entry name" value="P2X PURINORECEPTOR 7 INTRACELLULAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36981">
        <property type="entry name" value="ZGC:195170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022111657.1"/>
        </source>
    </evidence>
    <sequence length="118" mass="13693" checksum="E6A39CD2E8FE7683" modified="2022-01-19" version="1">MRDKAGQILPYTYEPEVESDNDEHEIAGVDYDDEGRLNNISWCSCGEYQIMPAVRESLCCKEINQVGQKMDNIEADLNCITEHPGFYSVCLDQWVLETVYFQYRQQYGQGRHNATENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3Q7</accession>
    <name>A0A8B8A3Q7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Uncharacterized protein LOC110990049</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC110990049</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110524.1">
        <property type="nucleotide sequence ID" value="XM_022254832.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110525.1">
        <property type="nucleotide sequence ID" value="XM_022254833.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110526.1">
        <property type="nucleotide sequence ID" value="XM_022254834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3Q7"/>
    <dbReference type="GeneID" id="110990049"/>
    <dbReference type="KEGG" id="aplc:110990049"/>
    <dbReference type="OMA" id="GDRFMIP"/>
    <dbReference type="OrthoDB" id="392925at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09032">
        <property type="entry name" value="KH-I_N4BP1_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11980:FF:000001">
        <property type="entry name" value="ZC3H12A isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056629">
        <property type="entry name" value="KH_N4BP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021869">
        <property type="entry name" value="RNase_Zc3h12_NYN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051101">
        <property type="entry name" value="ZC3H12/N4BP1_RNase_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876:SF35">
        <property type="entry name" value="LD08718P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12876">
        <property type="entry name" value="N4BP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23050">
        <property type="entry name" value="KH_N4BP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11977">
        <property type="entry name" value="RNase_Zc3h12a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N4BP1 first type I KH-domain" evidence="4">
        <location>
            <begin position="16"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RNase NYN" evidence="3">
        <location>
            <begin position="643"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="522"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022110524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022110525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022110526.1"/>
        </source>
    </evidence>
    <sequence length="955" mass="107799" checksum="321F9BAFAB52DBA9" modified="2022-01-19" version="1">MITEFEEHSQGAAKVQFTVSRTSLPNLLEWTERLQSRFRVTIQMQWELDQEAARLDEAAHVRWVALRGEAADCQKAKEYITIFCDAPHKMNVTYPEGIHTDLKDSQMEMEESYSCVLHFLKVGQLLIRSNDEMNLSLVLSVIEEKAAQYERHKDSSNQCITEFRTKYQGRNCQEPDLSDNDLEEDSMLVEDHSPNDTPPAQMMRSRSPGCLQTPAKHLLGGDPLKLKSKDSAVIPGQLSKLFSPVAEHSSISPDRKKIKSQPHPDQASSSPTPSPNFYRKYAHGSARLGTLNLSSSQQLAIQRVRDRGNFTQSEIDRVLEKVGSNWECADLITLLRRERTQQNIPESASHPPTKLDKLKNTQASLMQCLQEQSFTEPVHQELFSESRQKRYFMPPVHSPTSSAFSDEVLYMGIKKPPRDEFLQKKELSPFPDKHNKEEEKDLVMDGKDNVKDETDSILVISESDNEIVITNSSEESDTLEEFYIKGVLQERPKKESSSLAQHGTQLKKFNRPNLPAVERQKSEEQLGVIESLKKQIADLQDKLEQDRAEASSQQQVAILLQQTQREEMERQYLLQQQQLLEQQQQLQKQFELQEQALKAQQEVALKQLQQQQQEKQEQAMGTADLPREAIIIKPASRNPASPLRPVVIDGSNVAMSHGRQQVYSCRGIALCVAYFQRRGHQDITVFVPQGRRMQKPNAPDRPMKDQPILEQLESQGLLSFTPSRRIGHNYVNCYDDRFIVELAVQNDGVIVSNDNFRDLMGESPQWRFVIENRLVMYTFAGDHFMILNDPLGRKGPRIDQILCKSQPPGNAAGATSQQRLKTLQDPKGLSTAQPATKVGMQTLQGKTVLTLPATGVVPQWGTSAKTGAQIVGAGTAKGTQRPQTAPAPAPKAILAASFGQKAGRKDAKDHPCYEMLMGIFPNNEEEVLRVLTKNSDKEDANELVIQVLVEKEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIW1</accession>
    <name>A0A8B7XIW1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Microfibril-associated glycoprotein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110973549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080136.1">
        <property type="nucleotide sequence ID" value="XM_022224444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIW1"/>
    <dbReference type="GeneID" id="110973549"/>
    <dbReference type="KEGG" id="aplc:110973549"/>
    <dbReference type="OMA" id="CKDIQDR"/>
    <dbReference type="OrthoDB" id="7735550at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050373">
        <property type="entry name" value="Fibrinogen_C-term_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143:SF458">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19143">
        <property type="entry name" value="FIBRINOGEN/TENASCIN/ANGIOPOEITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034760707" evidence="3">
        <location>
            <begin position="33"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="4">
        <location>
            <begin position="46"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022080136.1"/>
        </source>
    </evidence>
    <sequence length="358" mass="39806" checksum="8F27F21F4FF15EC4" modified="2022-01-19" version="1">MGASASLGKFSTKFQVFLVIFWLLRCAQVSQAQCEGPCEGTGAYTLGQEPLPKDCKDIQDRGLTKSGVYTIFPQDVYLCVSLRVYCDMETDGGGWTVFQRRYDNRQNFFLRWLDYRLGFGSLGAEFWLGNEHLYHITPQDDYLLRVDLEDFDGGKSWATYAEFRIGSETDNYRLYIGNYTGGDAGDSLSAHRGSSFSTSDSDLSGGQCSSFRGGAWWYPRLCGDSNLNGRYLAGVHTEFGEGVMWHTWRGLTYSLRRTELKFRPMVASDRQPPTTPQETGGKAGEVDGEAEGDTGEVVEGEDTSSSVSSSSVEEEPEEITAAEPTEMAPELPFKGRVKGNLQPRKNKKKKSKGDKGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJ18</accession>
    <name>A0A8B7XJ18_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110973893</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with SCYL1. Interacts with JAGN1. Interacts with TMEM41B. Interacts with SVEP1. Probably interacts with PEX11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Golgi apparatus membrane</location>
            <topology evidence="1 15">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080793.1">
        <property type="nucleotide sequence ID" value="XM_022225101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJ18"/>
    <dbReference type="GeneID" id="110973893"/>
    <dbReference type="KEGG" id="aplc:110973893"/>
    <dbReference type="OMA" id="EMTYQKQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="5 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="17">
        <location>
            <begin position="344"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="19">
        <location>
            <begin position="613"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="18">
        <location>
            <begin position="816"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022080793.1"/>
        </source>
    </evidence>
    <sequence length="1222" mass="137854" checksum="AC2A4C83ECB549E3" modified="2022-01-19" version="1">MLTKFETKSARVKGLCFHPNRPWILTSLHNGTIQLWDYRMCTMLDKFDEHDGPVRGIGFHQQQPLFVSGGDDYKIKVWNYKLKRCLFTLLGHLDYIRTTSFHHEYPWILSASDDQTIKIWNWQSRNSIATLTGHNHYVMCANFHPSEDLVVSASLDQTVRVWDIGVLRKKNVAPGPGGIEEHVKSSMTPDLFMSGDVVVKHVLEGHDRGVNWACFHPTMPLIVSAADDRYVKLWRMNDAKAWEVDTCRGHYNNVSCVVFHPRQELILSNSEDKSIRVWDMSKRTCLQTFRRDHDRFWVITPHPTLNLFAAGHDSGMIVFKLERERPAYATHGNLLFYVKERYLRRLDFTTSKDVAIMQLRGGSKSPVYSMAYNPAENAVLICTRTSNIDNSTYDLYQVPKDVDKQNPDAPEGKRSSGLTAIWVARNRFAVMDRTHAVIIKNLKNEVTKKVQTPTCDEIMYAGTGMLLLRDNDTVTMFDVQQKRSLGSVRIPKVRYAVWSADMSHVALLGKHTLGICNRKLDSLCTIHENIRVKSGAWDESGVFIYTTSNHIKYAISNGDHGIIRTLDVPIYITRVKGQNVHCLDRECRPRILNIDPTEYKFKLALIHRKYDEVLHMVRTAKLVGQSIIAYLQKKGYPEVALHFVKEEKTRFALALECGNIEVALEAARALDDKNCWEKLGEAALLQGNHQVVEMAYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDTSGQYQCAMYLGDVSERVKILKTCGQKALAYLTAATHGLTEEAEELKEGFDEDERVPEVNPNAVLLQPPPPIMQSEDNWPLLTMSKGFFEGAMSRGKGGASMAAEVEMEAEEDGGWGDDAELVLDGGDEFGEDVAIGGGDDDEGGWDVGDDDLELPADLEVAGGPMAGAGEEGYFLPPVKGTSQTQVWCNNSSLPVDHVLGGSFETATRLLHEQIGVVDFTPYKTLFMQTYARARTAYLGLPALPPLMGYPHRNWRDAGARGGQAAVGLRLSHLVQRLQAAYQLTMQGKFAPAVDLFRGILLSVPLLVVENKQEIAEAQQLITICREYILGLSMEIFRKEQPKGTLDEQKRNCELAAYFTHCNLQPVHQILTLRTALNLFFKLKNFKTAASFARRLLELGPKPDVATQTRKILVACEKNLTDAHKLNYDEHNPFDVCGATYKPIYRGKPVEKCPLSGTCYMPEFKGSICRVTQVTEIGKDCIGLRISPLQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJ36</accession>
    <name>A0A8B7XJ36_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973599 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080206.1">
        <property type="nucleotide sequence ID" value="XM_022224514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJ36"/>
    <dbReference type="GeneID" id="110973599"/>
    <dbReference type="KEGG" id="aplc:110973599"/>
    <dbReference type="OMA" id="DHYEESH"/>
    <dbReference type="OrthoDB" id="6430388at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027883">
        <property type="entry name" value="Redic1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35158">
        <property type="entry name" value="CDNA SEQUENCE CN725425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35158:SF1">
        <property type="entry name" value="CDNA SEQUENCE CN725425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080206.1"/>
        </source>
    </evidence>
    <sequence length="706" mass="78594" checksum="91FCEEB50A88D13E" modified="2022-01-19" version="1">MNWVGGARNRLKMKDEKQRQKEFFEKMRYGNKVRQLSRSSAPQKAKLPASLDLLSLQAADYSATKFRKSDTMKSSKSKVKKVELDRSKGLFPFHHHHDDLELPMSPCAPSKLQLDDLDQSRNLDGRHPKEVTPQANTVPFVSPSQQIDQEIYRIKTAEDSKLQSQCSGQSHLSFQPSSPFHSTPMAQEFFNAPQQPLKHQGKHFEDLFFSFVPSDTSKPTQDPPEEFSAISNDGDEFDYSPLSSIPSESSVTSSLTVKSPSSQFNSTIEHNQVPLVSKTSTLPSQGKQLESSRPICSPVDLTQHTASFPIMIDSLPNEDYKSDSSLCGHKRESAQAQKPLDNPGSNQQQVDLMCKEKASFLSPFCKQAEVFTSAQVRSRKRRLGSEIAFSDTQSCEKSASCIGLSESSSNMSSGRAIEKEQKWLRKDDIALNTVGNSFVSGHKFTENSTTGNDERNVSKAPTKAMSKVCEQVLKEVLQLDSELCQHSPLHQDSSSHRGLQPPLMEVINLPVKQNKLEMEKFSCQVAEEKAVDEKLVDGHSKESCDQQVPNQSQELAESTPTGRTPVKLGELQPNASIDESQIQEYTENCEKQGEGNGADLSHDGATEVHVHEKVAYHQMSANNDGGTEESESQSTGTEPDVETLDDHIFRPLCEDQATQCNIYIIPTETKATLCEIQEFTSESQPGNRKIRKSEPMYDAYNECTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKB3</accession>
    <name>A0A8B7XKB3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973697</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080395.1">
        <property type="nucleotide sequence ID" value="XM_022224703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKB3"/>
    <dbReference type="GeneID" id="110973697"/>
    <dbReference type="KEGG" id="aplc:110973697"/>
    <dbReference type="OMA" id="NTERAYD"/>
    <dbReference type="OrthoDB" id="10147574at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001299">
        <property type="entry name" value="Ependymin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10697:SF1">
        <property type="entry name" value="MAMMALIAN EPENDYMIN-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00811">
        <property type="entry name" value="Ependymin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034174746" evidence="1">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080395.1"/>
        </source>
    </evidence>
    <sequence length="248" mass="28184" checksum="1ABF3279AA44F938" modified="2022-01-19" version="1">MLSSFIVCVLVVSAGAMAVKKPVLNAQTVFGISPREGEDERKPCATPKYFTFDQADFMTTLEEGRLTVEYVNFHGAYDEVLKRYSVETFLDFFNGTLLHLKVIAEYDEGKGYLVQRLGDEIECEVYDLEGKKFPEEFSFPEDATFLADSTLGDRDLTVESWYYVSEDGTKHNVKTVTKDECVPVSLFSRKFDPETGEELEVVNGQVINFKLGICDPESYFKIPEECKEVGVSKELSKNMKKMHRFGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKZ4</accession>
    <name>A0A8B7XKZ4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major vault protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110973816</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080630.1">
        <property type="nucleotide sequence ID" value="XM_022224938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XKZ4"/>
    <dbReference type="GeneID" id="110973816"/>
    <dbReference type="KEGG" id="aplc:110973816"/>
    <dbReference type="OrthoDB" id="6125719at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08825">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.550:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.560:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.570:FF:000001">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000010">
        <property type="entry name" value="major vault protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.550">
        <property type="entry name" value="Major Vault Protein repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039059">
        <property type="entry name" value="MVP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041139">
        <property type="entry name" value="MVP_rep_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043023">
        <property type="entry name" value="MVP_rep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021870">
        <property type="entry name" value="MVP_shoulder"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041134">
        <property type="entry name" value="Vault_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043179">
        <property type="entry name" value="Vault_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040989">
        <property type="entry name" value="Vault_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041136">
        <property type="entry name" value="Vault_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002499">
        <property type="entry name" value="Vault_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14165:SF16">
        <property type="entry name" value="MAJOR VAULT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11978">
        <property type="entry name" value="MVP_shoulder"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01505">
        <property type="entry name" value="Vault"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17794">
        <property type="entry name" value="Vault_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17795">
        <property type="entry name" value="Vault_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17796">
        <property type="entry name" value="Vault_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51224">
        <property type="entry name" value="MVP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Major vault protein repeat" evidence="12">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="10">
        <location>
            <begin position="118"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="8">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="10">
        <location>
            <begin position="170"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="8">
        <location>
            <begin position="173"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="10">
        <location>
            <begin position="221"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="8">
        <location>
            <begin position="225"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="12">
        <location>
            <begin position="277"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="8">
        <location>
            <begin position="281"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="10">
        <location>
            <begin position="326"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="MVP" evidence="8">
        <location>
            <begin position="330"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="14">
        <location>
            <begin position="388"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein repeat" evidence="13">
        <location>
            <begin position="473"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Major vault protein shoulder" evidence="11">
        <location>
            <begin position="535"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="695"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022080630.1"/>
        </source>
    </evidence>
    <sequence length="856" mass="95064" checksum="6B79F9A794FA5F83" modified="2022-01-19" version="1">MAGVVNIGPVDFVHILDVETNITRLEVGPQRLMLLNNEKLVAGPIPCVIVPPGHYCRVKDPMSHYEEGVQCELKHGQVEIRFYQEPFPLYPGEKLESAENLQDFSSRGYRKAMHPLPVVKVNQAIQLKAVLDHEVDGVQRQAGDLWQLEGPLTYKPTAEAEIVGWVNAAVIGQGQALHLRATQGFTDKGITRVSGEEWLVRKAGAYLPGVYEEVVELVSAYILKQDVALHLIAEHNCQDALGRQRQAGEEWMVTADDTEMYIPEIGEQAVKSVKKTVLEKGQYCIVCNPVDEDGHSQLGCEELRKGHTSFFLHPGESIKSGIQEQFVLSEDQAIVLQAISEFEDNSIPGEPQMRISGDRWMIHGPISYIPPVQVQVIDQGDGALVRRAIPLNDMEGIYVRNLKTGEVRAVMGPDSYLLTEHEQLWEKELPSLVLTILQNGGGCGSGDIRKLAYFESSIDADYAPGKIRDKTRVVRFRCPGNTAVQVYKYQEKTARVVFGPDMVILGPQEDFNVLSLSAGKPKVENALQTICLMLGPDYITDILEVETSDHARLKVRIAFNNYFEFERGNKLSEEAIFSVPDFIGFACRQVGSRIRGAVSRVRFDEFHRHSSKILQGAVFGFDADGNVKNRLKFKANHLVISNVDIQGIEPVDLTMRDSLIKSVQMAIEISTKSIERAAAHDAARKEQESQGLLERQKLLNEKEAEQERAKLFELQAEAAAIESTGQAKAEAQARAESLLIECHSAIDSARLKAQAEEVIHDAELQTQNLLRMSELSYKRRLNEAEIKKAIQLCNIEVSRFDAMVKALGGNTIIAIASAGPKLQAELMEGLGIESTLMNGNNPINLFKTTKEMIAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XLM1</accession>
    <name>A0A8B7XLM1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alkyl transferase</fullName>
            <ecNumber evidence="12">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC110974411</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>n isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = a di-trans,poly-cis-polyprenyl diphosphate + n diphosphate</text>
            <dbReference type="Rhea" id="RHEA:53008"/>
            <dbReference type="Rhea" id="RHEA-COMP:19494"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:136960"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.87"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms an active dehydrodolichyl diphosphate synthase complex with NUS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022081712.1">
        <property type="nucleotide sequence ID" value="XM_022226020.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081713.1">
        <property type="nucleotide sequence ID" value="XM_022226021.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081714.1">
        <property type="nucleotide sequence ID" value="XM_022226022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XLM1"/>
    <dbReference type="GeneID" id="110974411"/>
    <dbReference type="KEGG" id="aplc:110974411"/>
    <dbReference type="CTD" id="79947"/>
    <dbReference type="OMA" id="FDRRDLW"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1180.10:FF:000002">
        <property type="entry name" value="Alkyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022081712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022081713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022081714.1"/>
        </source>
    </evidence>
    <sequence length="356" mass="41549" checksum="1DA76D87A209C72B" modified="2022-01-19" version="1">MTTTVDSEWFPEEKYRVQKTWLQSFCTRVLKTGPVPKHIAFIMDGNRRFAKKASVEKAEGHRRGFDKMAEMLQWCLDLDIKEVTVYAFSTENFKRSREEVNGLMELARQKFARLLQEKEQLMKHGVCIRVLGELHLLPKDVQEAVAEAMYFSRNNTNAILNVCLAYTSRNEITNAMKEMAVGVEEGFLRPSDISEELLERCLYTSHSPDPDLLVRTSGEVRLSDFLLWQSNYSVLSFVDVLWPEFTIWHFYSAVLHYQRNHASVTAAREANKQDQAERQQRCDLTCAVRELETRREQNQETSTNMQEKLKQYTQERQARITKFLAHLERKRAENINCLLPEASDRERPVTKLVPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM31</accession>
    <name>A0A8B7XM31_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110974029</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081025.1">
        <property type="nucleotide sequence ID" value="XM_022225333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM31"/>
    <dbReference type="GeneID" id="110974029"/>
    <dbReference type="KEGG" id="aplc:110974029"/>
    <dbReference type="OMA" id="FCPFAIR"/>
    <dbReference type="OrthoDB" id="1733721at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022081025.1"/>
        </source>
    </evidence>
    <sequence length="122" mass="13550" checksum="797A31759ACA7977" modified="2022-01-19" version="1">MPPKPSGKGQKKAGKAKGAPRTDKKKKRKRKETYGIYIYKVMKQVHPDTGISSRAMSIMNSFVNDIFERIAAEASRLAHYNKKSTITSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XM44</accession>
    <name>A0A8B7XM44_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphodiesterase</fullName>
            <ecNumber evidence="8">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110974504</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022081884.1">
        <property type="nucleotide sequence ID" value="XM_022226192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XM44"/>
    <dbReference type="GeneID" id="110974504"/>
    <dbReference type="KEGG" id="aplc:110974504"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000003">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000005">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0140">cGMP</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="10">
        <location>
            <begin position="471"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="549"/>
            <end position="553"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="588"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="750"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081884.1"/>
        </source>
    </evidence>
    <sequence length="810" mass="90983" checksum="EB035EC5FA19FC6C" modified="2022-01-19" version="1">MSSPWKQVSGRRMPPLPGNSSPSIFGRRGASGECVGIGLNPTSVKMYLNANPWLVAEFLKENTNKDEVQKIINSSSIQLQRDSLYTYSGRCSRLQSTSTESLASTITTDRQKMLTSMVKVIEEAKELPKMLYHLSAVIAKAIEADDFFLYTVSTNGKDMHLCRENNGKIQEIMFGPVIPGTTISAYVASTKEAVLVEDILGDERFPRGAGIENSNAQAILCLPVLLPNGDLPGVLQLSRNYGNTAFTEESLEIASTYMLWAGIALHKVQMCKGLMKQRAFNDFLLEVSRVIFDDIVAIDTLTEHIIMFAKSLVSADRCALFLLDPKTEELYADLFDEGKVINGQPVFSKKQQIRFSIEKGIAGHVARTGEVVNIPDAYNDDRFNREVDIRTGYTTHSILCMPIISHGLVIGVVQLINKKDPMQTAFDKTDESNFRMFAVYCALALHYSKVYSSILHCERVLGVTQEQLAFHTCATAGDADKLLSRWTKRTIIPDDLNSFEFDCRPYTNILCDLLLHMTQKLCGEDCFDLVTLAKFFLTVKRNYRPNPFHNLPHAFNVAHCMYSLLMHSPGIFADFECQAMFIACICHDLDHRGTTNAFIQRSDSPLADLYTSSILENHHYQTTLNILQHPGLNIFARLPVNTYKQVIGLIQHCILSTDLMLYFGNRQEVAKLLMSNSLDITNTAHRPKVQALMMTACDLCATAKLWPNQRESVDCLYQEFYAQGDEEKRQGEQPMEMMDRDKQHTLPKQQIGFLTNVALPCFSTLSNIIPSAKFLLEGCKDNLVQWQQETEGKSTAMWDVGVSRVSSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XN54</accession>
    <name>A0A8B7XN54_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myosin-VIIa-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110974231</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081415.1">
        <property type="nucleotide sequence ID" value="XM_022225723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XN54"/>
    <dbReference type="GeneID" id="110974231"/>
    <dbReference type="KEGG" id="aplc:110974231"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002404">
        <property type="entry name" value="IRS_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF33">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02174">
        <property type="entry name" value="IRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MyTH4" evidence="11">
        <location>
            <begin position="143"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="10">
        <location>
            <begin position="299"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022081415.1"/>
        </source>
    </evidence>
    <sequence length="624" mass="71450" checksum="37C56C1159EE20D6" modified="2022-01-19" version="1">MPHERVSRKSGHQGARSPSSNQQPTRAMSPNRRVTPRSPSPDRRRARSPSPARKAVRSSKAQISREERSFSPTRNGLRSPGQIRKANRSKSPDDKGYHSLPSRSHKGPYTLERFAMMNFSIKPAKRPTVIAKSGSGGGMIWQHTTEPIQKPLLQHLSGNQQLSGRACSAFKAIMKYMGDYPTKKANLQGTLMTDKIFSDAMRYEELRDEIYCQIIKQLTNNILNVSEERGWELMWLATGLFPSSDTLRPELTKFLRWAQHKLAEDCQRRLQMVSGLPQQRKYPPHWVEVETIQHHYTQIFHFIFLPDDKSNASFQVSSTMTVADLCKSIANRLGLTSNKGFGLFLIMSSKVVALHEESDFFFDALRRQIDWEQEGIKSARSEENDMPVLAYQMFFLRKIWTDVVPGEDSQADTIFHYHQELSKFLRGYHHCPHQEDAAKLAALQFRARYGSDKAELQNVAKRLADFLPKDLLRSRSVDDWKRAIISTYNQPWITSMTKDAAKVAFLKIMYRWPTFGSSFFEVAKVTGSENTENVLLAINKQGVLIIDQQTKEVQKTFLYSEIQGWSGSEQSDFFLTVGNESKGVMKLHFKTKLGYKMDDLLTSYVRYKQKRPASGQNSTKAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNS5</accession>
    <name>A0A8B7XNS5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Tubby-related protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12 13" type="primary">LOC110974473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081827.1">
        <property type="nucleotide sequence ID" value="XM_022226135.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081828.1">
        <property type="nucleotide sequence ID" value="XM_022226136.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081829.1">
        <property type="nucleotide sequence ID" value="XM_022226137.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081830.1">
        <property type="nucleotide sequence ID" value="XM_022226138.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022081831.1">
        <property type="nucleotide sequence ID" value="XM_022226139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNS5"/>
    <dbReference type="GeneID" id="110974473"/>
    <dbReference type="KEGG" id="aplc:110974473"/>
    <dbReference type="CTD" id="56995"/>
    <dbReference type="OMA" id="RCYCTIR"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056159">
        <property type="entry name" value="Beta-prop_IFT121_TULP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF2">
        <property type="entry name" value="TUBBY-RELATED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24797">
        <property type="entry name" value="Beta-prop_WDR35_TULP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="SOCS box" evidence="7">
        <location>
            <begin position="353"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="485"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="835"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="871"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="937"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022081827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022081828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022081829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022081830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022081831.1"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120041" checksum="12C7B276A2753B6B" modified="2022-01-19" version="1">MYAVLENNPAARSDCTILSLSWKGTVPDSEKDKSYTRKRCYTEGWLATGNVKGIVGVTYTCSHARKNAATPSRTNFNLRGHNSEVVLVRWNEPFQKMATCDAQGVIFVWIKYEGRWSIELVNDRSCQVSDFAWSHDGRMALICYKDGFVLVGSVTGQRYWSSMLNLEAKLLCGAWAPDDKQVLLGTSDGQILVMDIHGAIVTQCTLAEDRPIKALLWSSEKFRMINVSDNESDEKPDKKKRKGSERRSRLCKKRCPVMAVDLGDSEIQLMKAYDDLTPISIKTEMTDIKMEWSSCGAFLAVGGAQPVESISAIKFYNTNGHLRFTLNIPSQRPLSALTWGHNDRRLFVACGAILHVAWVEKGVAPLQVLCREVITALVSEEKATAKLPLPGRLRTYTTDRLSLTVKGCIPDPTKLREFGSRPPPGNERLHCTMIRTGDDTNPSSSCYTLFLEYLGGLVPLLKGRRVSKLRPEFVIYDPKVSLDQKQVPGEEDERLPLATTIISSSSSSSSEDSEDETLARMIRRNGTSSGSPRLNAETSNGADLPRRKERQYNSLFLDSLPEQNRLVEVTSNIWGTKFKLHGLARFLPANLGQVHYRTSLLHLQPRQMTIALVELRPDAKPRRDDDEDADFDPNVFSEDEDEPGEPPPQPPMNRAGGPAPIAPMKSTNRSFSSSDLDVADQEPPPPAMEVSQPLEVTNENISSTSKVQPDREQFIRQGAIPKRRTSNLLKTSLEATTTVAGRTGALDVVENAQIINGTTEIVDGTLISSEPCDFDELQTDMPRWADSASQLIPAGVAQHHAPTDGGIANQSVDHKPLPMEVQEGVVVAVPSGRKRDVPLQAEKEPSVQSQRSLKPRENRPRSSSSPKSIMQMDTRTNSGSPQNGCGRDSSPSGSGKSPQEKRKRPKSKTRSRSESSAGTSPGGSGAVKQSDSEIGPEPEKAKKASKDRRTSLCGGGSPSWSRMKSHAGAVDSSESDADNANSSEETPAAGGGSAKSRRAKLMRQYADCKSKVFVMRNKAPLWNESTQVYQLDFGGRVTQESAKNFQVELHGKQVMQFGRIDGHAYTLDFQYPFAALQAFAVALANVTQRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQQ0</accession>
    <name>A0A8B7XQQ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">28S ribosomal protein S17, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110974772</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082330.1">
        <property type="nucleotide sequence ID" value="XM_022226638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQQ0"/>
    <dbReference type="GeneID" id="110974772"/>
    <dbReference type="KEGG" id="aplc:110974772"/>
    <dbReference type="CTD" id="51373"/>
    <dbReference type="OMA" id="FLMAHYK"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039193">
        <property type="entry name" value="Ribosomal_uS17m_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24088">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24088:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022082330.1"/>
        </source>
    </evidence>
    <sequence length="141" mass="15953" checksum="F1FCBAA04DAB7EC5" modified="2022-01-19" version="1">MSAHHSKILLGRVIGTGMMKTAKVRVERLVLDKYVMQYYPKRTTVFAHDAQEEAKEGDIVLVKQLTLPRSKHVKYLMDRIIYSQGNVTDPITRRKCDGSSYWEEAAPPYELDGDGLPRDEVVEPSSSTDTETERHSEGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRA5</accession>
    <name>A0A8B7XRA5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxyacyl-CoA dehydrogenase type-2</fullName>
            <ecNumber evidence="3">1.1.1.53</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3-hydroxyacyl-CoA dehydrogenase type II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial ribonuclease P protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Type II HADH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110974895</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:30800"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:30801"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>11-dehydrocorticosterone + NAD(+) = pregn-4-ene-3,11,20,21-tetraone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42020"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78600"/>
            <dbReference type="ChEBI" id="CHEBI:78601"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:42021"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:24613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15994"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:41993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42024"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78602"/>
            <dbReference type="ChEBI" id="CHEBI:78603"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:42025"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42004"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16330"/>
            <dbReference type="ChEBI" id="CHEBI:36713"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.53"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:42006"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42008"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28952"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78594"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:42009"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22433"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:22434"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42012"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17650"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:42013"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42016"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16962"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78596"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42017"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42028"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78604"/>
            <dbReference type="ChEBI" id="CHEBI:78605"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:42029"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 20">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.53" evidence="3"/>
    <dbReference type="EC" id="1.1.1.62" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022082521.1">
        <property type="nucleotide sequence ID" value="XM_022226829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRA5"/>
    <dbReference type="GeneID" id="110974895"/>
    <dbReference type="KEGG" id="aplc:110974895"/>
    <dbReference type="CTD" id="3028"/>
    <dbReference type="OMA" id="RHIFEND"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008209">
        <property type="term" value="P:androgen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05371">
        <property type="entry name" value="HSD10-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000215">
        <property type="entry name" value="3-hydroxyacyl-CoA dehydrogenase type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022082521.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="30684" checksum="E81B2F1C17D591E8" modified="2022-01-19" version="1">MWCVLAHFVLAQNKTLCSFRNLSCCVLNISTMSSIKSLRGLVGLVTGGGSGLGKATAQRLVKQGARVVVLDLPNSSGDDTAKELGDDCKFAAGDVTSESEVSAAIATARNSFGRLDLAVNCAGVGIAVKTYNFNKNRAHPLAEFQRVLTVNTVGSFNVIRQSAGEIGKNDPGPDGERGVIINTASVAAFDGQIGQAAYSASKGAIVGMTLPIARDLASQGIRVCTIAPGLFDTPLLAALPEKVRTFLARMIPFPSRLGHPDEFAHMVQFIVENPMINAEVIRLDGAIRMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSV1</accession>
    <name>A0A8B7XSV1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110975265</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110975265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083287.1">
        <property type="nucleotide sequence ID" value="XM_022227595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSV1"/>
    <dbReference type="GeneID" id="110975265"/>
    <dbReference type="KEGG" id="aplc:110975265"/>
    <dbReference type="OMA" id="ENACLEM"/>
    <dbReference type="OrthoDB" id="6118651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="46"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="214"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="926"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="948"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022083287.1"/>
        </source>
    </evidence>
    <sequence length="984" mass="110840" checksum="8830A898341D426B" modified="2022-01-19" version="1">MIGCVSSLIPRLNYGRTLFAMACAHLPDVPAVKRSAPNSSQQGRPQNDLLLWIAKELGQDWRRLAIHLGLSQANVDDIDGQPHKSQKDKSFQMLTSWTRKLRNDKNGYEILITMLESCDRNDIAEMVENYDRNHNPPSPNPDNPDYLPAKMRQILKDKYGEHRFVFCSSVDEKRFEFSELFTSLELTKTAVVSTRLNVHTELLDLRNADGDAYKRILLRGPKGCGKTVLLKAVSQDWSKQNDNPRSLASNYDLLFTIDLREVSEEEDLADAVFAQLLPEDVRLSRDSLRSYMDDKEKQSRVAILLDGLDQLICCGNRLSSKTVPEYFYKMITKKVHRESLVIVASRTLTKKLPDAYQIIDVGGFSRENVATYVSKFFRDNKEKMLFLQNVLESYSSDLTDFSTYPSVISALCELLQSAGTEAFPKGLTEIYDHIFKDMVRQYKSSICIHGNGPISYFFKSLLKSVDYADLFPKFHNPVPVRGEQLEKFFYDIGRVALQGLLCTRENRDFEEFDFGRDALAIACSVGILVKDDEKSVAVRFCHPSVQEYCASKYCQSLATSKPTKFRKKLGRFGDQINLYRFCCGNSKESSDLIMKFIIPPLAQGRVTLGTSLEGRIALACLAEFHSDSFLQHLEPCLTADGSIKVEYSSVGSWLLRVLCDVLNTACRSDTFRLSLQTVRTLNVTCGMSTQCISSINTIVGHLSNLQTVVLVNNSDQIPSWLATTPNGDAVCELVSHLRNHHLSKLTIVNCGLGSRCVSHILSQLPYLEFLDLSNNPRIIWSKLREPARYPKLTTLKLKQCGITEDEAKSFVEFLQQQSDLTELSVDWNDLETTGLAIIMDAVCDLGKLQLVSAERKRSDGMSLPHEETVRMLRRCSALKACNVSKWKPKDEEAGAEMLEAASHLDDFQALIFDERSFMVDEFGNVVSSPNEASDPNDDVGNEASSSNERSDTSGMLDEKPYSCTDTLLGFSPHRKKSYSQQHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XTD0</accession>
    <name>A0A8B7XTD0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lens fiber major intrinsic protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110975713</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084113.1">
        <property type="nucleotide sequence ID" value="XM_022228421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XTD0"/>
    <dbReference type="GeneID" id="110975713"/>
    <dbReference type="KEGG" id="aplc:110975713"/>
    <dbReference type="OMA" id="RRLIMYV"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022084113.1"/>
        </source>
    </evidence>
    <sequence length="275" mass="29072" checksum="6895A37CC2DA997D" modified="2022-01-19" version="1">MAQVVDKMSAEVRSAAFWRACLAEFIGTLLFIFLGLGSTVTKAPDLVRISLAFGLAIATLVHCTAHISGGHLNPAVTIGFLVTHAITPLRAIVYVFAQVLGGMVGAGILRGLSPSYWSGGPTVPQQGVEEWQAFIMEILLTFQLVFTVFSTVDPDRKGFAGSGPLAIGLSVGLGHLAAIEISSASMNPARSIASAIVSSNWTAHWAYWVGPILGGILAAGIYDIVLAPTADMNRLRKCATCVYDPSEEESRQDIDLSIINQGQAQDEPFAGGNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XU21</accession>
    <name>A0A8B7XU21_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110975325</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110975325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083416.1">
        <property type="nucleotide sequence ID" value="XM_022227724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XU21"/>
    <dbReference type="GeneID" id="110975325"/>
    <dbReference type="KEGG" id="aplc:110975325"/>
    <dbReference type="OMA" id="YQVHWPF"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19085">
        <property type="entry name" value="AKR_AKR11B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="15"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083416.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="37577" checksum="DBDA5CFD98546E93" modified="2022-01-19" version="1">MDRVALSGGDLMVSPICVGAWQFNGGKADETWPAQDETVSKAIVDKALELGVNFFDTAEAYGDHNSERVLSRCLAGRRQDVIIASKFGRHVRGSVKEYTAIDIEQALTASLQALQTDYIDIYQVHWSVNMKDTTETVAELDRQKSLGRIRHYGICNFGSSSIDKFLTAGGRPCSLQVPYNLLWRAVEFNILQTSHQHGLSVLAYSPLQQGLLTGRFHNASEVPEGRRRTRHFSKDSTNLSRHEQKGAEAETFKAISDIRNLCDKENIPMSSAALSWILAQEGVASVIVGCRTPQQLEDNCKLVNLSQNVVKRLSDCTSALKEILGDNPDMWAKNSRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XU97</accession>
    <name>A0A8B7XU97_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110975880</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084424.1">
        <property type="nucleotide sequence ID" value="XM_022228732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XU97"/>
    <dbReference type="GeneID" id="110975880"/>
    <dbReference type="KEGG" id="aplc:110975880"/>
    <dbReference type="OrthoDB" id="10060990at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF5">
        <property type="entry name" value="DUF4371 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034547349" evidence="2">
        <location>
            <begin position="20"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="3">
        <location>
            <begin position="211"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084424.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="42652" checksum="C7EAD9CB8AE28AAE" modified="2022-01-19" version="1">MNFMLTYLAIMAELSLVLQRNTTTVDVVIEKTCAVKQQLQNVLAPTELNAILINGLDDPENPTKFRSLELETRQPRSTRSNATVSCSDSESVQSTCKGAVSVKQKVALQATKIIEGTVNNISKRFEPLFSHRVMKAAAAIINPANWPESLEGLAEYGVEYVKDLYSHFRGLLENRHVDPTQCQLQWIELKLHLSKKRCLEMESQNKQKQKVTRNSHQNTFLNPISMWSTVLSDEEYQLRFNHIFPIIRIILVLPVHTSELERGFSHMNVTMNNQRTHLTTESLTDLLTIKLSGLDFRTYDPIGAIMKWCPWRNEGKIKRRLNTRPYGPRSKQFKPGEPNDMEKSKSLPCPQFPYTSWQSDSSDGEPSDDDHDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUC7</accession>
    <name>A0A8B7XUC7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110975429</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with THUMPD1. Interacts with SUN1 (via N-terminus). Interacts with TERT.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
            <location evidence="1 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="13"/>
    <dbReference type="RefSeq" id="XP_022083615.1">
        <property type="nucleotide sequence ID" value="XM_022227923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUC7"/>
    <dbReference type="GeneID" id="110975429"/>
    <dbReference type="KEGG" id="aplc:110975429"/>
    <dbReference type="CTD" id="55226"/>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000006">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000019">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="17">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="16">
        <location>
            <begin position="282"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="529"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="19">
        <location>
            <begin position="765"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="977"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="992"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1014"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="630"/>
            <end position="632"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="637"/>
            <end position="643"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="725"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022083615.1"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115499" checksum="3AB5B33B6E92B372" modified="2022-01-19" version="1">MVRKKIDNRIRVLIENGVTLGRRSMFVVVGDHGKDQVVILHHMLSKAVVRARPSVLWCYKKELGFSSHRKKRMKQLQKKIKSGVLDIKEDDPFELFIAATNIRYCYYSETHKILGNTYGMCVLQDFEAMTPNLLARTVETVEGGGIIVILLRTMASLKQLYTLSMDVHSRYRTESHQDVVGRFNERFLLSLATCKRCMVIDDKLNILPLSSHILSIQPVPPKTMDDTLSPSEAELKDLKASLQDTQPVGVLVNRTKTLDQAKALLKFVEAISEKTLRSTVCMTAARGRGKSAALGLAMATAVAFGYSNIFVTAPSPENLRTLFEFVFKGFDALDYQEHLDYELVQSTNPEFNKAIIRVNIYREHRQTIQYIHPGDAVKLGQAELVVIDEAAAIPLPLVKELLGPYLVFMSSTVNGYEGTGRSLSLKLIQQLRQQNATGGSSSKTEARSSSEAGSSATGRVLHEVSLDESIRYSVGDDVEQWLNGMLCLDVANVPRISSGCPLPQDCDLYYINRDTLFSFHKASEVFLQRLMSIYVAAHYKNTPNDLQLLSDAPAHHIFCLLGPVDPTQNALPEILCVLQVCLEGQISKQSIMSSLSRGKRASGDLIPWTIQQQFQDNDFPTLSGARVVRIATHPDYQGMGYGSRALKLLQRYYEGQFPSLGENSSAPTELNTVQSEEVDLLEEVIGPRKNLPPLLSKLSERPAEKLDYLGVSFGITSELLRFWKKAGFVPVYLRQTPNELTGEHSCIMLKIINEDMSPQPDTESWLMAFSKDFRRRFVSLCSYQFRNFPPSMALSILHHKDYKLETQPLQADELESYCSKYDLQRLELYSRNMADYHLIMDLVPTVAKLHCLGRIRAHLSAVQSAIFVGLGLQHKTVDCLAKDLDLPASQILALFNRNIRKVVQEFSGILEKEVEGKIMTASAKEVVMEPVKQTLAQDLEEAASEIKAKQKKELERLKLLDMSQYTIKGQEDEWNKALQSGKAKNMVSIPSSDKEGPQRKRHKVADQEMESPKGNRKKKVKLAKSAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY19</accession>
    <name>A0A8B7XY19_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084676.1">
        <property type="nucleotide sequence ID" value="XM_022228984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XY19"/>
    <dbReference type="GeneID" id="110976040"/>
    <dbReference type="KEGG" id="aplc:110976040"/>
    <dbReference type="CTD" id="6124"/>
    <dbReference type="OMA" id="ALYGTWR"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="277"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022084676.1"/>
        </source>
    </evidence>
    <sequence length="390" mass="44146" checksum="A710879607BD58BA" modified="2022-01-19" version="1">MAVAAARPLITVYTEKNEASGTNVKLPAVFKAPIRPDIVNFVHTNMRKNSRQPYAVSKLAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQAAFGNMCRGGRMFAPTKTWRKWHSRTNVNQKRYAMCSALAATAVPALVMSKGHLIDRIPEVPLVVSDAIQDYKRTKEAVLFLKKFKAWPDIKKVYKSKRIRAGKGKMRNRRHVQRLGPLIIFEKDNGISRAFRNIPGIKLMNVTKMNLLRLAPGGHVGRFCIWTESAFRRLDSLYGTWKKPSAEKKNYNLPMPMMMNSDLNRLLKSQEIRRALRPKRLDANQRKVLKKNPLRNVRAMFKLNPYSKTQKRQAKLAEERARARRQAHYDKKRGITPADPPAEKASEAPKASGKAKKQPKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYB0</accession>
    <name>A0A8B7XYB0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ubiquitin recognition factor in ER-associated degradation protein 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022085879.1">
        <property type="nucleotide sequence ID" value="XM_022230187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYB0"/>
    <dbReference type="GeneID" id="110976694"/>
    <dbReference type="KEGG" id="aplc:110976694"/>
    <dbReference type="CTD" id="7353"/>
    <dbReference type="OMA" id="WMMQQLC"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000002">
        <property type="entry name" value="ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="14"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="114"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085879.1"/>
        </source>
    </evidence>
    <sequence length="305" mass="34437" checksum="238E227589EB05CD" modified="2022-01-19" version="1">MFGFQMFGQFPQQFNTQYRCYSVSMLTGAYREDVERGGKIIMPPSALDVLTRQNIVYPMLFKLTNKKIARTTHCGVLEFVADEGKVYIPYWMMRNLLLDEGDLLTVESCSLSVATYSKFQPQSVDFLDISNPKAVLENILRGFACLTKGDMIAIKYNNKDYELQVLETKPSDAVSIIECDMSVEFAAPVGYVEPERQKPAEQDTEDMQVDGPGITHYVDTDTFMAFKGQGNRLDGKKKHSDAKPVPLNAPVMRRGIPNYDYQKGTITFIRTARPAVANGNSEDVPDSFEAFRGEGQKLRQKNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZ17</accession>
    <name>A0A8B7XZ17_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PWWP domain-containing protein 2A-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110976490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085492.1">
        <property type="nucleotide sequence ID" value="XM_022229800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZ17"/>
    <dbReference type="GeneID" id="110976490"/>
    <dbReference type="KEGG" id="aplc:110976490"/>
    <dbReference type="OMA" id="GSIKPFC"/>
    <dbReference type="OrthoDB" id="5964980at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010369">
        <property type="term" value="C:chromocenter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20140">
        <property type="entry name" value="PWWP_PWWP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000036">
        <property type="entry name" value="PWWP domain-containing protein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, DROSOPHILA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16112:SF22">
        <property type="entry name" value="PWWP DOMAIN-CONTAINING 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PWWP" evidence="4">
        <location>
            <begin position="455"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022085492.1"/>
        </source>
    </evidence>
    <sequence length="560" mass="62422" checksum="4B544C18C7481E39" modified="2022-01-19" version="1">MAAGQEKHSLKSGTMIAVEVEQAVNNVLMVCFRSGGKVYRGALIDTQIGRFPLGISSPVSLCDRLKNNFDELSHSESAATVVVMPQENGSGEGAAKVEHSALSYRQSYFQDMPLPYPRPLLMNKPTSFKEKKMSNTNVRTRPIRLRPRRPLCSKCRSQCSNNVAASASHTSGKKSDKLSLIRKHKKDDASTKCVANKKNKTTTVDVPEVRKTSPVIKISYASPQGKGHVVRIPAKTHSASYRNSTESNHTNKLKQTEKLKSQKILKKARTPPKNKSTKPVLNGFIHGSDSKSYHEQHRRIRIIKSEGTYYSTATNHCEDSKSDTRSQLKDQSESLTSSATVAASSLYCISKTTSKEHREPNVKSSNIQESNMLGKGNALEWNTSREYSSYNQEKSGSDHMDVSSSVEGNMDVCLESEESNMISLPGKDRVPSLKVQVHKKNVTKSRLQDGREMCIGDIVWGKITGFPWWPGRIVEIVVSRHEDGTLLSQLAQITWFASTTISHMPLTELYPFLPYFAERYNRKKKGIYRDAVRQATEAATTLSAEVRALNTMFETSTLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZT3</accession>
    <name>A0A8B7XZT3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidylserine decarboxylase proenzyme, mitochondrial</fullName>
            <ecNumber evidence="13">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="13">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110976981</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. May be involved in lipid droplet biogenesis at the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="13">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase alpha chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="13">Anchored to the mitochondrial inner membrane through its interaction with the integral membrane beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Phosphatidylserine decarboxylase beta chain</molecule>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
            <orientation evidence="13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="13"/>
    <dbReference type="RefSeq" id="XP_022086413.1">
        <property type="nucleotide sequence ID" value="XM_022230721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZT3"/>
    <dbReference type="GeneID" id="110976981"/>
    <dbReference type="KEGG" id="aplc:110976981"/>
    <dbReference type="CTD" id="23761"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03208">
        <property type="entry name" value="PS_decarb_PSD_B_type1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033661">
        <property type="entry name" value="PSD_type1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5035030763" description="Phosphatidylserine decarboxylase beta chain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035030764" description="Phosphatidylserine decarboxylase alpha chain" evidence="13">
        <location>
            <begin position="420"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="13">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="13">
        <location>
            <begin position="121"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="13">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="13">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="13">
        <location>
            <begin position="419"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="13">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022086413.1"/>
        </source>
    </evidence>
    <sequence length="451" mass="51645" checksum="83AA25647FA8D6FD" modified="2022-01-19" version="1">MQVYVSNTTLKPLPCTRYETSVVVETVTRPDTRPDARPWTRPVRSNRIRMETKCHICHKPSSSTGSFSEQVVRTYSSEGSQVPKVSWMRRITKGFVNYGRNLKWVPIPLGVGFAYICYQQYGHIKKRERRRELSSNDIADRLATQWQINIYKALPLRFVSRLWGQVNSVDVPYGLRKPIYSLYTRLFNCDLSEALVEDLTTYQNLSAFFRRELKPTARPLDKSKSLVSPCDGKVLHFGKVERGWMEQVKGVTYTLQGFLGPKTANQQEGEVKQVSNDHFQSRLTTKAGNRLYQCILYLAPGDYHRFHSPADWTIKHRRHFPGLLFSVNPGIARWIRGLFSLNERVVLCGEWEHGFFSMTAVGATNVGSINIYFDEELRTNKKGKFKQGEYRDHDYTAITRDSAGIRVAKGDSIGEFNLGSTIVLIFEAPKDFDFSFRPGDKVRLNAGIGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZZ1</accession>
    <name>A0A8B7XZZ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LanC-like protein 2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110977021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LanC-like protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086474.1">
        <property type="nucleotide sequence ID" value="XM_022230782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZZ1"/>
    <dbReference type="GeneID" id="110977021"/>
    <dbReference type="KEGG" id="aplc:110977021"/>
    <dbReference type="OrthoDB" id="10257263at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020464">
        <property type="entry name" value="LanC-like_prot_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF21">
        <property type="entry name" value="LANC-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01951">
        <property type="entry name" value="LANCEUKARYTE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086474.1"/>
        </source>
    </evidence>
    <sequence length="405" mass="45427" checksum="092EF9844506B1D0" modified="2022-01-19" version="1">MSKRKRQEGEMEPREFANKFSPFSGEISERWQQIPEEFVGKLKTGISHLLPRMVEGLRREDDHDDSIYTGRTGIALLYLHLQTTFPQGDDLVTAYQHLKAPLQRLRGRRHTFLCGDPGPLAVGAVVLSKLGRTSESQACIAKLHDLHRASLDPGLPDELLYGCAGYLYALLFLQSRLPEAAIDGAVVERVYRRMIHSGESLSKREGSKSPLMYAWHEKKYIGAAHGLSGILCLLMQVTTPYAQEHLHSHIKPSVDYVLQLAFPSGNFPSSLGNNSDRLVHWCHGAPGAIHMLLQAHKVFGENKYLEAARRCGDVIWERGLLRKGYGLCHGTAGNAYALLALHQTTKDSKYLYQAFKFAEWCMDYGKHGCRTPDRPFSLFEGMAGTIYFLADLLNPDAARFPALYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0E4</accession>
    <name>A0A8B7Y0E4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malate dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110976738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022085982.1">
        <property type="nucleotide sequence ID" value="XM_022230290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0E4"/>
    <dbReference type="GeneID" id="110976738"/>
    <dbReference type="KEGG" id="aplc:110976738"/>
    <dbReference type="CTD" id="4190"/>
    <dbReference type="OMA" id="HTWVNGT"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01336">
        <property type="entry name" value="MDH_cytoplasmic_cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000010">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000002">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011274">
        <property type="entry name" value="Malate_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01758">
        <property type="entry name" value="MDH_euk_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003916">
        <property type="entry name" value="PRK05442.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="6"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="156"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022085982.1"/>
        </source>
    </evidence>
    <sequence length="333" mass="35976" checksum="D0D098578F394B7A" modified="2022-01-19" version="1">MAQPLRVCVTGAAGQIAYSLLYSIAKGDVFGPDQSLELLLLDIPPMMGIVEGVVMELSDCSLPLLKNVVATDDYSVAFKDVDAAILVGAMPRKEGMERKDLLKANARIFEGQGKVIDQVAKKTVKILVVGNPANTNCLITKTCAPSIPPANFSCLTRLDQNRAQFQVANRLGVACDKVRNVIIWGNHSATQFPDVKHATVLDNSGQAGPVYGAVKDDAWLQGDFITTIQKRGAAVIAARKLSSAMSAAKAIGDHMRDWWFGTNPDEWVSMGVVSDGSYGVPEGLVYSFPVKISGKEWSIVQGLEISNFAREKMDLTAKELQGEKETALSFLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y124</accession>
    <name>A0A8B7Y124_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15 16 17">Tumor necrosis factor receptor superfamily member 16-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16 17" type="primary">LOC110977231</name>
    </gene>
    <organism evidence="14 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086862.1">
        <property type="nucleotide sequence ID" value="XM_022231170.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086863.1">
        <property type="nucleotide sequence ID" value="XM_022231171.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086864.1">
        <property type="nucleotide sequence ID" value="XM_022231172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y124"/>
    <dbReference type="GeneID" id="110977231"/>
    <dbReference type="KEGG" id="aplc:110977231"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047526">
        <property type="entry name" value="TNR19/27/EDAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12120">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12120:SF10">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665492" evidence="12">
        <location>
            <begin position="20"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="13">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="246"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="436"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022086862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022086863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022086864.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="63913" checksum="FD653E54575AD760" modified="2022-01-19" version="1">MNLLHVESAVVGLLLYVTSFVGVDGPPTGLALQANDIHPQDVCSAYDEYRDEDSGECEICIKCNPGFGSTAIECGYGRVARKGKCEPCQPGSTYQANVASTESCQPCRLCDENAVVVSLCNVTHNTVCGSCKPGYGSDPNHKGSCSRCTLFNDDDRPEECQTFPVPTEPPTTSPSPPLQPPTTEVHPTTVDIPLVTTVESPTTSTPLDPGKGRSSVEAWKIAVPVSFSAFIILLVVCFLWWRKGSKRQHTEGQNSTDREEGTAAAAEMTSLTTSPSDGDPSPATPPSATPNGGLSDQELQLGSTAEIHPNGSPPVQQVPPPNVPPVEVNENGQETRENGTALPGENVDDTEPDSHSGECTPNQACSPGLVQDDNESLENSVHTSAGCDYADSRGSTKEHAPRVVSSHLLPSIPEKMNGMKSSADKKFKHVKKCAAKTRQRSLSDQGRMKSPPSSPEILNNGADQPMLDTAVRENINNKKKKKEEKDYQMNLSKACSIGSWLHWVDLSSQCRKTVLQMLTPGGACPSISTYKELGEALGLRRDTELRTCKDINNVFDTLATRQEVTLEDILLCADKIERKDVVKVICKEVLQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y2N4</accession>
    <name>A0A8B7Y2N4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14 15">Pyroglutamylated RFamide peptide receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14 15 16 17" type="primary">LOC110977519</name>
    </gene>
    <organism evidence="12 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087436.1">
        <property type="nucleotide sequence ID" value="XM_022231744.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087437.1">
        <property type="nucleotide sequence ID" value="XM_022231745.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087438.1">
        <property type="nucleotide sequence ID" value="XM_022231746.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087439.1">
        <property type="nucleotide sequence ID" value="XM_022231747.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087440.1">
        <property type="nucleotide sequence ID" value="XM_022231748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y2N4"/>
    <dbReference type="GeneID" id="110977519"/>
    <dbReference type="KEGG" id="aplc:110977519"/>
    <dbReference type="OMA" id="IHMMIEY"/>
    <dbReference type="OrthoDB" id="9979846at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004983">
        <property type="term" value="F:neuropeptide Y receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000291">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000611">
        <property type="entry name" value="NPY_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF15">
        <property type="entry name" value="OPSIN RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01012">
        <property type="entry name" value="NRPEPTIDEYR"/>
    </dbReference>
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        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="75"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022087436.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022087437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022087438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022087439.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022087440.1"/>
        </source>
    </evidence>
    <sequence length="384" mass="43485" checksum="C4B9840B498B8645" modified="2022-01-19" version="1">MESDDSFDDHLAYTSLVLENKTLDELLASLNFTSLGEFIDFYGVELEPIAYDLSAEADAGLITSYTVIFLLALVGNILVVFAVVHKRSMRTVINAFIVSLATSDLLITLFCIPFTLLEIITVDWVLGTYMCKLLNYITMVAVVSSVLTLTTIAVERHHAICYPLRARIIQTPRRAAILIAGLWVSSMLLVSPLLFVHKVILKEDPLIATTYKFCREAWPHPEQKKAFTLLLVLFVYVIPVLTMTVLYLRVVHRLWIRKAISPLEAQGSQANASSLRNKRRATKMLIVVVILFAVCWLPFHVVSIIRDFSHMRDSERNRLMLAIVQLIGFSNSFNNPIVYAFLNENFKRTFRKTLCVRPQTNTAKKKAKKSTTHLVSPYAVQTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y372</accession>
    <name>A0A8B7Y372_ACAPL</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein C10orf67, mitochondrial-like isoform X1</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">LOC110977181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_022231073.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="110977181"/>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR22382">
        <property type="entry name" value="RIKEN CDNA 4921504E06 GENE"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4709" evidence="3">
        <location>
            <begin position="48"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="28"/>
            <end position="53"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="558"/>
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            <begin position="76"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="404"/>
        </location>
    </feature>
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        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15821"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086765.1"/>
        </source>
    </evidence>
    <sequence length="558" mass="63817" checksum="94C4F9840DDB24F3" modified="2022-01-19" version="1">MAEEETETKLAVAAMTSQELAKLALEDAMLADHSSGDDSSGDDDGDIRPSIADQQKVGFFSQDRATQTERSDIINLKEMTKDIQGLLKESQRLKRELAVTKQVMQADYENRLQEKTLDMYVRINERVEELQKMHSERVEIVRRSFRQQLADAIVKLNNDWKKHAGLKMQAEQRRLASKNDQMGEDYEKLVQQVAQQEGIIDMLRMQIAQIAQEPRSEASTPSAVYEVEHLRDEMGNLQQRIDSMEEAMDAKDEQIDELNKDVERLTKDLEKERVQVKQLLHELEESKATAQQELASLRRNADKQRLQMEREMQDKMSKARDEMIEAKEEERKKMVTLARKHAKEAQQQEEERQRILEEQRKAALALEKKERENALQASKSDTDINRLRKMETFLKLEVARLKKELARTTRMWEKKFAILQKSLYALKDESFVRQTLQKQAATLHHASVSYAADTPLGILPSSQPTNTPRRQNPPLPGIGQMSKVRDPRLDLISPYTVSPPSGRGVELFSAAASQIVDNDEADEDSDVEGVIPLPSPPPKWKQDSRPSTSGQVIVLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4H7</accession>
    <name>A0A8B7Y4H7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Midnolin-B-like</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="primary">LOC110977422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022087230.1">
        <property type="nucleotide sequence ID" value="XM_022231538.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Ubl_midnolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039336">
        <property type="entry name" value="Midnolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23010">
        <property type="entry name" value="MIDNOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23010:SF1">
        <property type="entry name" value="MIDNOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022087230.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="49197" checksum="0008B8284726C1DB" modified="2022-01-19" version="1">MPHTIYPEDPCSGPATMAVNLGMEAPTSTSSNHGLLTVHIHPTTGGRFTVEIPRHASVDVLKTKISKQLRIAKERLTLLHRETHLKRGTLEENLVTDGSKLTLLPLVESGLVSQRQDQTLMQALQTLSETQVDNFLNGKQPLTLALRLGSHMVYVQLQLAGTPGQHSFLNCHKAAAPSQPKPVVTHHQATPTASTCQSPPVSKEYQPPCPQSQCPLHGKTACMAPSLANRPPQQYPSNIPPSSCGHARPMASAPSPSPPSPPTWPRSGACIDSVHQHSPGVFSGTFSGILSAAVQDGQGRPKKDISTIAHILGDLLHAAPLYRQHIHQHRRQRASCAQAHHAQRTTGNNAAPASSGGGVPVRPQTPPEKKQFIMQENNHTRSKMAYLQEMMRERQARRQARRNTRAPYPGQDHSQRNNASHVEKALSPGENSKDRALADNCYPALKQDYLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4S0</accession>
    <name>A0A8B7Y4S0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein LOC110977952</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110977952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088193.1">
        <property type="nucleotide sequence ID" value="XM_022232501.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977952"/>
    <dbReference type="KEGG" id="aplc:110977952"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058808">
        <property type="entry name" value="GAIN_ADGRA2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26588">
        <property type="entry name" value="GAIN_ADGRA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034543890" evidence="8">
        <location>
            <begin position="35"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1068"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1102"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1131"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1170"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1212"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1255"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1284"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="9">
        <location>
            <begin position="891"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1323"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1373"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1329"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1416"/>
            <end position="1428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022088193.1"/>
        </source>
    </evidence>
    <sequence length="1502" mass="163937" checksum="16FBDA235A437A6C" modified="2022-01-19" version="1">MRFVGAAGRHIMKFPIMFIASMALFTGSLPQVQGLTCSYSCRHRSTYSCGFWGWQQCNRNRYKACYRCCDGWSGSTSSGCSTPICSPSCTNGGRCTRPDYCSNCNRGFYSPRCSSCSFISNCLDVYCSSSTNQRCGECAGDYGTRLGSAYKLSADQRRCIKQCSWRTGSNACYPGTCTNGLCTCRSGFSGTDCRTLSRSQRPTISEYRGTLIKGSTNLESPAAQGSTTTVYTDVTNFTSIQVLWKTSYQPTGLPQRPPYIHSVSLGIVSARVSVSVNKARGGIHYIGFRSCSSAGSRSNPASNLVVCEATFDIDYTSWSPSTGDVLTYTVYSSAGGHMKLFNRDSNSNVLTRYYTSKQTSATATFTFALDGPSHCVGTTSCQNSMLSVGSNVITQPVITVRWFGWIDSRAGIKEYHLQVRQMSGTSGNEMTEVSHGPPVYEGVTASGQTVTLPSAGVYSVVLSVIDNVDNVRRSRRFVFFDDNRNDVTIDPTAPMRVLSHDGATEYGWVSFPDSSPKRDKWLRLDWQGHFLNKRHVNKGLLKPIGPFANGLLDADYDQNFGQRGRDAIPNAGGVAEFRVLVKTDRSGSAIVDPNNENSDNWLTKGTDTHHLYNPLARDGSSVRFWVEARDLAGHSARDSLLFRVDSSPPVVDCIEMIVDLHDISVKFRTVDEHSGLKTIKWRLLENETQTVLEIGTETVTRVNTTEGCSPQGCVCIPLGECYATAYQIKPTVPAGVQDRDFVVMLTVTNQAELETNEMTQISVTAENVGQVSQSLASITSDTPSIDESAVAFAADLLDSIVGVQDTSPEVTENVVKIVSNLLQMDDDRLGAADEVANSSSRIVKSLGRQISNALATGQNISHMTRGLAVEARAFHPSALAHGVGFAVFEGENRTGTFDENSVGIYGSEDVPVEEASASIHLPPEVVNKSSGGDSIPVSFVVYQTSKFFRSQRTNGAPTSLPTSFIDSRVIAATVEGTQVRDLPPESPVVIAFLPDKLISVSEHQTAVTECVFWDFNLRAGIGEWSSEGCQESSQVGGRIVCHCSHATNFAVLVKVHGPLKHPNFALDIFSKIGCGVSIAGLSITVALYLAIRSLRTLEASRILISFCCSLLLLYLVFLAGIEQTSSRSGCIAAAVLMHYFALTSMAWMGVEAANLYLKLVKVFNSDVSHFMVKASLVAWGLPAVLITIILAADYTVYDGEDRCFLKSGDAFYFGQLLIIGLVFLFNLVVFVLVFRKLTCEVMGTPDKSNRDTVGSRLRTMASVAVLLGLTWVFGLLSVWGTASFAFQVLFCIFNSLQGLFVFLLFVVRQRKVREGVSNLLCRRKEKPSESSTANNQLTASKTTGEPSVVFKRGPCNNDHVDYDGYDNVAVATAQDTSRPQPRPPSWHPYDEVDPAEPPSYGNIGEPTTKRALSPPKLHKPFCKAKPGKVRSEEYENADAQTAKKKPDPPPKRPRRHHQVGLGEPAMYQNTAIPVPKKVPRPTPPPRPGHSQYYEEVLYNNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7R2</accession>
    <name>A0A8B7Y7R2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Doublesex- and mab-3-related transcription factor A2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110978514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRT family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089263.1">
        <property type="nucleotide sequence ID" value="XM_022233571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7R2"/>
    <dbReference type="GeneID" id="110978514"/>
    <dbReference type="KEGG" id="aplc:110978514"/>
    <dbReference type="OMA" id="RFRDCRC"/>
    <dbReference type="OrthoDB" id="6162476at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14370">
        <property type="entry name" value="CUE_DMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1040.10:FF:000001">
        <property type="entry name" value="doublesex- and mab-3-related transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005173">
        <property type="entry name" value="DMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF118">
        <property type="entry name" value="DM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03474">
        <property type="entry name" value="DMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="8">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="6">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022089263.1"/>
        </source>
    </evidence>
    <sequence length="432" mass="46167" checksum="689237093E2EE27F" modified="2022-01-19" version="1">MMERPVIDMQTMSLLRGPLTEKGARKPKCARCRNHGVISWLKGHKRHCRFRDCRCPKCNLIAERQRVMAAQVALKRQQAAEDAIAMGLRACSPGTGGSFGMMSANGPLFGSSDSGDELSPRPMDIVDEDGDHQDITEKKTKIESANEKENGRGTPPSSQSERNNNNRHSSGKSKSESLDTFNGFAASFVSNFRPGRLTPIEILTRLFPAQRKAVLELVLQGCNGDLVKAIEHFLSASEDTHQHSPSGAALPPPPPISRGVVGERPSVVGHESFGQSGVHGLQAAFRSTLCSEKHPVGSMKSAFTPLPPSSAAGSSVPLLFTPRPPHPFHAEALLGRTPLFAPSSVGDLSSSMSSPAMASPRFAFPALHPFHLSGKFPSAGEGYPRLIFAPYATCPPDCIQCPGSRTSMHSEPEKSPSGTTDGSIANSAVDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y895</accession>
    <name>A0A8B7Y895_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">receptor protein serine/threonine kinase</fullName>
            <ecNumber evidence="5">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">LOC110978597</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022089444.1">
        <property type="nucleotide sequence ID" value="XM_022233752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y895"/>
    <dbReference type="GeneID" id="110978597"/>
    <dbReference type="KEGG" id="aplc:110978597"/>
    <dbReference type="OMA" id="HSEICGM"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23532">
        <property type="entry name" value="TFP_LU_ECD_BMPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000018">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000021">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000055">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017194">
        <property type="entry name" value="Transform_growth_fac-b_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF68">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037393">
        <property type="entry name" value="TGFRII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034372927" description="receptor protein serine/threonine kinase" evidence="23">
        <location>
            <begin position="35"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="25">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="230"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="236"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19 21">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037393-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR037393-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR037393-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022089444.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="59769" checksum="1323A40F89B74A6F" modified="2022-01-19" version="1">MATWIGLYRTNNYWNFTVLSTFLSLLFAVVTVLAEEGMKCYCSEHCPEDAPNNTCVLRPGGWCFSQIQTGEDGIIHEGAITSHGCLPPIDDGGQFLCKAKKHTIPRIMLCCNDRPMCNVDLSPTLQPTTTTHVPVETLDQYEYDTAHQIVLLISVTVCAVLFILTSTFLYVRLKKREARRRYDVEVSRTRQNEPYLTNGDTLSELLNRASESGSGSGLPLLVQRTIAKQVQLIRCVGQGRFGEVWKAKWRGEHVAVKIYLTEEESSWFRETEIYQTVLMRHENILGFIAADIRGSGSWTQLFLITEYHEHGALFNYLRYNILDTKAMLRLAHSAANGLAHLHSEICGMQGKPAIAHRDIHSRNILVKANGACAIGDMSRAARFLSESNEVDLPTKCRAGNKRYMAPEALDSTLNTNAFESYKNADVYSFGLVLWEIARRCVTRGIVEDAQVPYFDFVPSSNPTYEEMQKVVIQERRRPDIPNRWSGDDSLLSIARVMTQCWHPNPAARLTMLRVKKTLAKMQEEDFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8D3</accession>
    <name>A0A8B7Y8D3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Luciferin 4-monooxygenase</fullName>
            <ecNumber evidence="2">1.13.12.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110978158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>firefly D-luciferin + ATP + O2 = firefly oxyluciferin + hnu + AMP + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10732"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16792"/>
            <dbReference type="ChEBI" id="CHEBI:30212"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58038"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.13.12.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.13.12.7" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022088615.1">
        <property type="nucleotide sequence ID" value="XM_022232923.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978158"/>
    <dbReference type="KEGG" id="aplc:110978158"/>
    <dbReference type="OMA" id="AWPNTDF"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000003">
        <property type="entry name" value="Long-chain-fatty-acid--CoA ligase FadD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0455">Luminescence</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0599">Photoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="171"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="11">
        <location>
            <begin position="442"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022088615.1"/>
        </source>
    </evidence>
    <sequence length="531" mass="59169" checksum="0254A4FDFEB6FB83" modified="2022-01-19" version="1">MTIFKSKFPDVSFPNMAVDEFIMEPFDHYGDQVAMVDGITGHMYTYKQIKLLVRKVRFSLHSKGFKADDVFAIYSPNCLEYVVVLLGVMNAGGVVTTMNPKYTVGTLPXKIAPPLLHFAQCYQKSPLISRSKMHRFFXGGHFFLTKEVVVFGEHPGCTPYLSLLNNDGKSLPRPKVNPDDTVLLPYSSGTTGQPKGVMLTHRNIISNMFQRTSKHILEVYPDDCTLALLPFFHVYGLNYCLLQFLWLGIRIVSLPYFQPESFLRSIQDYKVTLLSLVPPLMLFLAKSPLVDKYDLSSVRQITAGAAPLSQEIMETIANRLNLKSLIQGYGLTEVSCAISVTPYNVINYGSVGLLLPNAEMKVIDVTSGKPLGPGQDGEIWLRGPQTMKGYLKNPEATAQSIDKDGFLHTGDIGHIDEDGFLWIADRLKELIKYKAFQVPPAELEALLLTHPQILDAGVIGVPDQAAGELPRAFVVRKTESLTPEMVQDFVAEKAAPHKWLRGGVVFIDQIPKSASGKILRRELRKRLQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8R0</accession>
    <name>A0A8B7Y8R0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Lysosome-associated membrane glycoprotein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lysosome-associated membrane protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC110977909</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Cell projection</location>
            <location evidence="17">Growth cone membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Secretory vesicle</location>
            <location evidence="15">Synaptic vesicle membrane</location>
            <topology evidence="15">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 20">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088131.1">
        <property type="nucleotide sequence ID" value="XM_022232439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8R0"/>
    <dbReference type="GeneID" id="110977909"/>
    <dbReference type="KEGG" id="aplc:110977909"/>
    <dbReference type="OMA" id="SYRCSED"/>
    <dbReference type="OrthoDB" id="6248302at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF35">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="6 20 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034629206" description="Lysosome-associated membrane glycoprotein 5" evidence="23">
        <location>
            <begin position="21"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="24">
        <location>
            <begin position="122"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022088131.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="38452" checksum="47F45990FB507BCB" modified="2022-01-19" version="1">MNCSPFPLLFFVVYAGLTSEAGIANVTGDTTMTTPTTPPIITNGTAITTPSPSGPTGSVTPTTRATNATTPAPTSPAATTPSAANMTTKPEVVTTPMTGNTTGNTTGPTNITITTVAPAPVVPRFQVNNSDGETCMLLNFNAMMMVNYTTKDKGVQTATIPIMNATSYEGFCNSTMPRTFTLYYPDNDSFCASLTLLFNATSNATYYNAEAISVRYVEPCFPSNASKYNGTDQIKYSPSYNGTIGKSFQCQKISPVSKNRSFALVLDDVFLQPFAERSADPGRFGEVESCRDVPSTPKPTATSGPSHPPTKPSPSHAGEIAGIVLGLLAAVLIVGFVVYMVRKRRYKPISYGNLDEEITRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y956</accession>
    <name>A0A8B7Y956_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Low-density lipoprotein receptor-related protein 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110978301</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088890.1">
        <property type="nucleotide sequence ID" value="XM_022233198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y956"/>
    <dbReference type="GeneID" id="110978301"/>
    <dbReference type="KEGG" id="aplc:110978301"/>
    <dbReference type="OMA" id="DIWFYRG"/>
    <dbReference type="OrthoDB" id="5986723at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:Wnt-protein binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042063">
        <property type="term" value="P:gliogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000230">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000132">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF13">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034876482" evidence="8">
        <location>
            <begin position="28"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="123"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="344"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="385"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="474"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="516"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="564"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="696"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="734"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="775"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="864"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="906"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="7">
        <location>
            <begin position="954"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1086"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="9">
        <location>
            <begin position="1124"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022088890.1"/>
        </source>
    </evidence>
    <sequence length="1190" mass="132967" checksum="539291E11EC11AD6" modified="2022-01-19" version="1">MNAKGLSRRSFQMALIVLSWFAANSDCSISTSEPYDLVFVTNLDPPAIFKAPADTFEFTAIPGLDDHLSTPVAVDYDPVDGMVYWTDVRRETISRAFPDGTGFYVVVSNLKVPDGLSLDTVNRMMYWTDTGSDQIERATMDGLDRSVILDLRSPTEDVDTVQPRAIVVDTSNDRLYWTDWGSAPKIEQANTDGRLRRVLVDTNLQLPNGLALDTNGRRLFWCDAGLDRLESIDLNGGSRTFYNNIISLLFDIHPFDVWFYQGQLYWSDWRFLKLVRMQFNPIVVSLHGSTGFERAGGLHIHDDSFVDHSCFGRTPCKLGERCRQFQDHYECVCQDGFAGLFCKLDNPCASSPCNNGGICRQSSRLEGGFFCKCTDRYMGTYCERFVPACNSSPCMNGGTCFDEVPDSFRCECTAGFVGTTCERKSYPNDLAFVANLMPPGIFMAPTDTFNFTLITGLTDYLSRPVAIDYDPVDGMVYWTDVGHNTISRAFSDGTGFIVLVSGLKVPDGLCLDVVNRVMYWTDEATDLIEKATMDGQDRSIVLNLKNESIDEVKPRAIVIDTTHGHLYWTDWGSAPKIERANIDGSSRTVLVDTGLQLPNGVALDLEGNRMYWCDAGLDLIESTDLLGNDRRVHAELSSEEIHPFDIWFHRGVVYWTDWRFKTILRMDFIPTTPVALFGSTTFLRAGGLHIYADTLSAHECRNPMTCKEGERCRQYKYTHKCVCKDGEAGANCKLENPCASSPCKNEGKCFQSTSTDGDYFCQCTDRYTGKSCETFVSPCESNPCMNDGRCVVELPDSYRCECPSGYVWENCEHESKPHDLVFVANLDPPGIFVAPTDTFNLTEIPVLDQKISRPVAIDYDPVDGMVYWTDVTLSTISRTLLDGTGLLVLISGLKNPDGLSLDIENRVMYWTDSGSDLIERATMDGQDRAVVLNLTNGSISDVMPRAIIVDSKNSYLYWTEVGSSPKIERANTDGTSRQVLVDTDLKWPSGLTLDIEGGRIYWCDAGLNRFESTDLLGDDRRIHADVDPIEIHPFDVWLYGDNLFWTDWRFPQLFRMNFLPDMGVEGMGPLILTKAGGLHIYSDNSTDHSCADSMPCGEGERCRQFQTSYQCVCKDGPDGASCNLNHPCKNKDCSLAGTCYRSASIESGYFCKCVDRYSGTNCEIYEKPEKLNINLSSPLQGNDKGQGNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YA51</accession>
    <name>A0A8B7YA51_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium-coupled monocarboxylate transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110978998</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090123.1">
        <property type="nucleotide sequence ID" value="XM_022234431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YA51"/>
    <dbReference type="GeneID" id="110978998"/>
    <dbReference type="KEGG" id="aplc:110978998"/>
    <dbReference type="OMA" id="FWLFAFT"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022090123.1"/>
        </source>
    </evidence>
    <sequence length="629" mass="68510" checksum="3E482B2E10900BE6" modified="2022-01-19" version="1">MAELEVVGTFGVWDYVVFGCMLLISLSIGFFYGCTGGKQRTTSEFLLADRNMNPIPVALSLVASFISAITVLGTPAEVYIYGSMFWLFAFTYPIIAFVVSRLFIPTFFRLNVTSANEYLELRFGKAVRISATLTFFLNMVFYMGIVIYAPALALNAVTNISLWGSVLATGLVCTVYTTIGGMKAVLWTDVFQTCLMMAGFLAIIIEGTIRLGGIGNVWQIAEEGGRIDFWNFNIDPSIRHTFWSIVVGGCFTWSTTYAVNQSQVQRYMTTGSVKRARIAMCLAAVGMIIVVSAACLSGLVMYSFYAEKQCDPYTSNKVSQTDQLIPYFMMELFGRVPGLPGFFTSAVFSAALSTVSSGLNALAAVTAEDLVKPCFPRISQERFTLITKGIALGFGLLCIVISYITSLLNQGVLQLALSLFGMTGGPLLGLYSLGLFFPWTNSKGAITGLVAGLGFAFWVGVGAVIYPPSAYRPPLTIEGCNLTTTTPSPLLTTTLPPEIPPTAELYTLSYAWYACVFWLVTVFVGILASFLTGATKRQDIDPVLRSHCVDGLYCCLPEVIKKPLRCGDEKPDYTKKDEEADVLEVKEINPYLTDPAVDNDGVDIVTVATEQPENTGKENGLDNEVFSAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAP2</accession>
    <name>A0A8B7YAP2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sushi domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110978715</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089622.1">
        <property type="nucleotide sequence ID" value="XM_022233930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAP2"/>
    <dbReference type="GeneID" id="110978715"/>
    <dbReference type="KEGG" id="aplc:110978715"/>
    <dbReference type="OMA" id="LRICMEN"/>
    <dbReference type="OrthoDB" id="10050617at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000014">
        <property type="entry name" value="Membrane cofactor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF59">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 9" id="KW-0768">Sushi</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="158"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022089622.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27093" checksum="4923CE00DF4D3211" modified="2022-01-19" version="1">MNIAFSAGIAIIVYIDTEMMSFIVQLDTKFQGQVSGLLGNLNGNPDDDLQFPNGTIMDSGSSLKELHEFGLEWLVKEEDSIFTYISPFDYSTYHFPEFSPTFGIPDLNEVSQEIKDLCGDSVECVFDAVTTGSLSFANATLVVTGTITEVQNSLVKIVSCGFPGDIENGQMSGSVYLVNATVDLTCDEGFDLKGSSRLTCKADGQWSSAIPLCVSTPQWFAGIIAAIVVCALLIALAFSCLIYFISKSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBB4</accession>
    <name>A0A8B7YBB4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="5">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110979223</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="7">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022090513.1">
        <property type="nucleotide sequence ID" value="XM_022234821.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979223"/>
    <dbReference type="KEGG" id="aplc:110979223"/>
    <dbReference type="CTD" id="5332"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16211">
        <property type="entry name" value="EFh_PI-PLCbeta4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000024">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="12">
        <location>
            <begin position="687"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="806"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="474"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1203"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022090513.1"/>
        </source>
    </evidence>
    <sequence length="1286" mass="145950" checksum="E9251E1A136CFA69" modified="2022-01-19" version="1">MAKLYDFQWQITVPDGLLNGATFDRYDEDSGTVEQNCFFRVDEYAFFIIWKSEGREGQGLELSQINDVRKGIAPKEASYLSKVGPILDPYAKGNVEDRTITVCSGLDLVNINYMHMVASTSELAQEWFDGLLKITHNFKANNVCPMTSLMKHWMKICIQVNPSGNIPVRNLTRTFASGKTEKIVFKSLEELGLPSGKNDEIDPQTFPFSKFYDLYHKICPRTDIEDLFKQISKSSQEGLTVSELIEFHNDKQRDPRLNEILFPFYDRERILKIIQTYEKDPEFVKREQLSVDGLCRYLMSDENAPVFLDRLTLYQDMDQPLSHYFINSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGRNEDQEPIITHGLAMCTDINFKDVIMAIRDTAFVTSEFPVILSFENHCTKFQQYKLAKYCEEYLGEYLLQEPLPDHPLEAGTPLPSPNKLKRKILIKNKRLKPEVEKRQLEQLRLKPGTIMNLEDEEDEEPESDSDSEDDVQPPSASAANKRTRRQSKQSDTQDNEEENSEETPSEETAEDKEKTGPQPVDAHPELKSPPGTNKIGSTADLESVAGETAKASGDATTKPATPAPVEKDTPVSTPETAEPVKLKPSLSMKNSNKKNLSRVQLLDSRAEAKAEAKALAGENLQGVEQLSQDEEAAMVANYRYTGATTNIHPFLSALVNYAQPVKFQGFDVAEERSFHFNMSSFNEAVGLGYIKTSCIEFVNYNKRQMSRIYPKGGRYDSSNYMPQIFWNAGCQMVALNFQMPDIGMQLNQGKFEYNGSCGYLLKPDFMRRPDKSFDPFSESPVDGVIAATCSVRVISGQFLSDKKVGTYVEVDMYGLPTDTIRREHRTKTVPNNGLNPVYNAEPFVFRKVVLPDLAVLRIAVYEENGKLIGQRILPLDGLQAGYRHISLRTEGNFPLSLPTVFCCIQLKTYVPDGLGDFVDALSKPMEYLSQAEKRAKQMQSMGIEENDISEVPVAGKKNSKATLRQGAKSPTTPTNTMNSFAPTTNSVMPCLSTDTLQKDKVYQKVLKKQSKEIETLQKKHSKECTLVKKSHDTVVDKMTGAHDKEKLSEEKSLEKAIKKKGESNCGDLKIETENKVHSIVKVHKMRVKGVVSEQNKEWCKITARQQAEMNDLKEMHVHQQCDVLRKLMTQKQTDQRKTLEGKHSREMKELEANQIKTSMESRKLVSHDKSIKNKAEKERRIRELQSNSLKKFMEERKRLQVRQSKEIDELTAEHSKQMDLLIRANEEMIEAHKAKLKETNNSNSKVEAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBB8</accession>
    <name>A0A8B7YBB8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Neuromedin-U receptor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110979232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090539.1">
        <property type="nucleotide sequence ID" value="XM_022234847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBB8"/>
    <dbReference type="GeneID" id="110979232"/>
    <dbReference type="KEGG" id="aplc:110979232"/>
    <dbReference type="OMA" id="MNRTSEC"/>
    <dbReference type="OrthoDB" id="10036964at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24243:SF208">
        <property type="entry name" value="PYROKININ-1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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        <location>
            <begin position="40"/>
            <end position="62"/>
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    <sequence length="381" mass="42037" checksum="C469E65EC2576554" modified="2022-01-19" version="1">MEQDIEMNRTSECSNLPSLNLTIEEDASVYLLNGGISTTMLVVLFSILAVGIPGNLAFLYVIARVPYMRTTTNVYLASLAMADLTFLLTSIVQYTFYFTNPVRTHLPTASVVGCVGAFIPQYITYFASISMVSLVSHERYNAVCKPCANLGQGNRVKRSLKLVAGSWLVAFVLAGLVMFRYAYLFKFCAIWPEEEPYHSLPIQLGYCVAGSHWGLIVGHVLESAVFIVAMVTNAMMYTLIIIGLSTRAKHKLQKDPVTPPSVHALQALQVRNQVTRMLVANGVVFFLCQTPFIAISLAFLCETLAGIPSDVTYRKYVLALTVCHVFVFLNSAVNPIIYNVTSRHYRQSFVEAFSLSTSRGGKSNANVAETEPNNCFALTVK</sequence>
</entry>
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    <accession>A0A8B7YCV9</accession>
    <name>A0A8B7YCV9_ACAPL</name>
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        <name type="scientific">Acanthaster planci</name>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFE9</accession>
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            </authorList>
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        <property type="nucleotide sequence ID" value="XM_022235627.1"/>
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        <property type="component" value="Unplaced"/>
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        <property type="entry name" value="Nav/unc-53"/>
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        <property type="entry name" value="SAM/pointed_sf"/>
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        <property type="entry name" value="PROTEIN SICKIE"/>
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    </dbReference>
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            <begin position="948"/>
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        </location>
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        <source>
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        </source>
    </evidence>
    <sequence length="1126" mass="125803" checksum="C4F8EE7DBF7ADD51" modified="2022-01-19" version="1">MLTLKSHAANNGAVGSSRQPRQPIESWTSKTVKMGERSRQNGLINSPRGLYGRGKVPITSKQGVGGEWALKECEEHTTWLNGILKKHKSRPISDLRKSISDGLTLVNILEILFNGKIQGVQTRPIIRAQRLENINLCLRFLENRGVEIQHISADELTDSNLRATLALVTCLRKRFEAFHTSNSAHGDGSAASMDKSIRPPTEDSIQPSIGREASIHSFHSQHSVHSQHSDGIPSRPRSSEIPATIPSDDERPSLNVGSPTPVNGDTDLMLPGTMADSDPDEPRPELADKPENVVVPSVTQLDSQGVSQHGVSSRRQQVASSQKKSFRPPPLTKRNSEGIQGSPIMSRSPIRDALTQSVEEKLKNLLDSPNPGGGPHRNLPMDDGELLEPPPPRRRSYHGDDDDDEENEAEVTIEDNKLQAMLEDPDKFEDYHKDWDRYVSDYIPSHSAEKTEGPRAQTLLDRQASQPTPPPSSQQRSLPFFHAPPTQHMGPVQSPPPVANRSPFLNGPHPMSSRDPHSHGSIYNDSGRRNRQYNGMQPYYPGEETPTQRRKLPSYSDHIQRHPPKHRMPNSTNPNNIYIPEGPRPQNSPVWQPQGYPRDLQQPRRRRDQYEPRPNYGPQRDYDQQAVDEDHQRVRQYLNHMHGDSLPNARGIPMEELSRRQDYRHPPSSRKLEPNSPYMYMDHMPLDSRTQQTYLRNGGGLDGSRDFAFSLSDSSSRSSTPPLPPLSPDNSDLESVPNSPYLGKKVQRSISVGVLPSGVHFPPHKLNDSSMGMKRRKNSSNRSGSSSHKMFEPKAALRRSAGKGRRKMAKGVKSSSSSLVGVSSTTSSKRKSPNSRGLPVVPLLKVQEHTEHTDSDLSSHHSDRRSDSDNENDSGSASHLGSLPSKASIKVSETHQQQHSATESVEPPDAENIRQQLVVLENMYKEILQVIGNDRRERLLENPGERLSVSSMSTASAKTQNKPKASSGKASKRRDKDIKMVNKRFARVESHVVTLARSVAHLSSELRSQSAMFHEIEALRHEVSQLRDMHVLNANDVLNGGMKFRPIVPLCSSPQKIKKLTKFFGEEPPLLSMFLRELGYEKFVSLFEKEGIGMVELPYLSEERLENIGVPTGPRLRILQEAQLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFS1</accession>
    <name>A0A8B7YFS1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xaa-Pro dipeptidase</fullName>
            <ecNumber evidence="10">3.4.13.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Imidodipeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proline dipeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC110980074</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline</text>
            <dbReference type="Rhea" id="RHEA:76407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:195196"/>
            <dbReference type="EC" id="3.4.13.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.9" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022092088.1">
        <property type="nucleotide sequence ID" value="XM_022236396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFS1"/>
    <dbReference type="GeneID" id="110980074"/>
    <dbReference type="KEGG" id="aplc:110980074"/>
    <dbReference type="CTD" id="5184"/>
    <dbReference type="OMA" id="DAHALFF"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102009">
        <property type="term" value="F:proline dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48480:SF2">
        <property type="entry name" value="PEPTIDASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="16"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022092088.1"/>
        </source>
    </evidence>
    <sequence length="485" mass="53650" checksum="A88F4AF55D6C0266" modified="2022-01-19" version="1">MPASPVYSQGGNTLSVHVSLHADNRGRLLTRLRANQDVPAGAIVLLEGGKDINQYCTDIELVFRQESFFMWTFGVELPGFYGAVAVDTGKTVLFAPKIPEAYIVYMGDLPSNEVLKERYAVDEVHYVEEIVTVLEAMKPSTLLTLKGVNSDSGLTSHEAVFDGIDKFKVNNALLYPEICECRVFKSAGELEILRYVCALSCEAHKDVMRKAQPGLMEYQLESTFRYHVYYHGGCRKVAYTCICASGHNSSVLHYGHAGAPNNRQIQDGDICTLDMGGEYYGYAADITIAFPANGKFTADQRIIYETVLKANHAVLNAMKPGVLWPDMHCLAERTILEELKRHGLVQGDVDEMMKVYLGAVFMPHGLGHFLGCDTHDVGGYPKGVERIQRPGIRNLRTARVLEAGMVITVEPGCYFIAATLEPALKDPQMKQFLCPDVLERFKSFGGVRIEDNVLVTENGAENLTAFVPREVAEIETLMAEGQSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YFZ2</accession>
    <name>A0A8B7YFZ2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione S-transferase omega</fullName>
            <shortName evidence="3">GSTO</shortName>
            <ecNumber evidence="3">1.20.4.2</ecNumber>
            <ecNumber evidence="3">1.8.5.1</ecNumber>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Glutathione-dependent dehydroascorbate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Monomethylarsonic acid reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110980113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate</text>
            <dbReference type="Rhea" id="RHEA:24424"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58539"/>
            <dbReference type="EC" id="1.8.5.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:15969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17826"/>
            <dbReference type="ChEBI" id="CHEBI:33409"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.20.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GST superfamily. Omega family.</text>
    </comment>
    <dbReference type="EC" id="1.20.4.2" evidence="3"/>
    <dbReference type="EC" id="1.8.5.1" evidence="3"/>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022092154.1">
        <property type="nucleotide sequence ID" value="XM_022236462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YFZ2"/>
    <dbReference type="GeneID" id="110980113"/>
    <dbReference type="KEGG" id="aplc:110980113"/>
    <dbReference type="OMA" id="MWPWCER"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050610">
        <property type="term" value="F:methylarsonate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000009">
        <property type="entry name" value="Glutathione S-transferase omega-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000123">
        <property type="entry name" value="Glutathione transferase o1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="4">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="101"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092154.1"/>
        </source>
    </evidence>
    <sequence length="231" mass="26601" checksum="F5836D58C02B7E8C" modified="2022-01-19" version="1">MSVKHLEAGQPLPPLKDGSIRLFSMKYCPFAQRSRLVLKIKGIDFEEINCNLTKKPEFLLERNPDGKVPVYEHNGEVLIESTVICDYLDEIYPDPPLYPKDPLQKAKDKIVVAAYGSKVIPAFYKCLRSGAEDDEANLIAGLTLYDAELKKRGTPFFGGQQPSMVDYVTWPWNERLMVFDKLMNTLKAKLPDLDAYFQRMLTTPMIQAFNDREYYKTFYEGYAHGDPQYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YI28</accession>
    <name>A0A8B7YI28_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Exosome RNA helicase MTR4</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Superkiller viralicidic activity 2-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">TRAMP-like complex helicase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">LOC110980177</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="RefSeq" id="XP_022092267.1">
        <property type="nucleotide sequence ID" value="XM_022236575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YI28"/>
    <dbReference type="GeneID" id="110980177"/>
    <dbReference type="KEGG" id="aplc:110980177"/>
    <dbReference type="CTD" id="23517"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000004">
        <property type="entry name" value="Superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="26">
        <location>
            <begin position="126"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="27">
        <location>
            <begin position="353"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="16"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00069430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022092267.1"/>
        </source>
    </evidence>
    <sequence length="1023" mass="116012" checksum="857E3BF1317EC38F" modified="2022-01-19" version="1">MADAFGGDLFTVFEDDDQTAKKRKRNPVLDGRKSSFLEGNQQLDAGDHEVPEYTTGKKPKLSLTADELNLAEILPQVKCQTVESIEGCSHEVALPLNEEYEPLKPSGNKPAKEYPFILDPFQKEALKCLENNQSVLVSAHTSAGKTVVAEYAIAMSLRDKQRVIYTTPIKALSNQKYREMYEEFQDVGLMTGDVTINPTASCLIMTTEILRSMLYRGSEIMREVAWVIFDEIHYMRDKNRGVVWEETIILLPDNVHYVFLSATIPNARQFAEWICHLHKQPCHVVYTEYRPVPLQHYIFPAGGDGLHLVVDEKGEFRQDNFGAAMSVLRDSGDAAKGDSMNRGRKGGTKGPSNIFKIVKMIMERMFQPVIVFSFSKKECEAYAMQMSKLDFNSSSEEKALVTEVFNNAIDCLSDDDKKLPQVENVLPLLKRGIGIHHSGLLPILKETIEILFSEGLIKALFATETFAMGLNMPARTVVFTNARKFDGKDFRWISSGEYIQMSGRAGRRGLDDKGIVILMIDEKMSPGVGKNILQGQPDPLNSAFHLTYNMVLNLLRVEGINPEYMLERSFHQFQNYSVIPELFDKLKKLEEEYNQMEIPQEESVEAYYKIRQQLNKLGREIQAFITKPKYCLPFLQPGRLVKVKNEADEFGWGVVINFRKKANQKMNSPRDDPLYIAEVLLNCSKESIKNAATDSAKPPMAGEKGEMAVVPVLLNLITHISSVRLYLPKDLRPLDNRQSVGKSVQEVQRRFPDSLPLLDPIEDMGIKDENLRKVVEKIEAFEERMYSHPLHKSPDVQKLYSQYEQKAKLASEVKAAKRELKRAKTVIQLEELKCRKRVIRRLGYATVADVIEMKGRVACEISSADELLLTELIFNGVFNSLKPEQITALLSCFVFEEKSKNVPRLSEQLSGPLRQMQDSARRIAKVSAEAKLAVEEEDYVESFKPQMMDVVFAWANGSNFAEICKMTDVFEGSIIRCMRRLEELLREMCHAAKAIGNTELENKFASGIAKIKRDIVFAASLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YK57</accession>
    <name>A0A8B7YK57_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cyclin-D1-binding protein 1 homolog isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979999</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091931.1">
        <property type="nucleotide sequence ID" value="XM_022236239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YK57"/>
    <dbReference type="GeneID" id="110979999"/>
    <dbReference type="KEGG" id="aplc:110979999"/>
    <dbReference type="CTD" id="23582"/>
    <dbReference type="OrthoDB" id="41588at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="8">
        <location>
            <begin position="205"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022091931.1"/>
        </source>
    </evidence>
    <sequence length="346" mass="38092" checksum="4E77B553489CF4F1" modified="2022-01-19" version="1">MASSQLDNIFDTFVENLDLVTSKLKEEDSPRPTAPDHSLEEFWKKLGAAFESLSAEATKLALWFSKPPLPKPEECQSLIASVEMSTIALVSVFYGLPKEHGLMLRRATRHTVMGAVEGIRNLAKRIKQDHYHSSDSQLHATGNVWERCDAFKTLPRNNKDALLSAVSNVRGLVNDAVDELKELQETGGGPEGWDDLGLIAGAPSGDTNMQEGWSEHDRMLLPPCSGLLKASASCVKKVSGAVQAHGQWKENWLVAQLDDLGEIAERISPAADDLVMCLYAPIRQQDVRQNANKLAEVLLSLLDQTKTSHVVKEADNSWLTFLSKAVDHNLEKITQLTAPASPHNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKP9</accession>
    <name>A0A8B7YKP9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Neuronal acetylcholine receptor subunit beta-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110980083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092106.1">
        <property type="nucleotide sequence ID" value="XM_022236414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKP9"/>
    <dbReference type="GeneID" id="110980083"/>
    <dbReference type="KEGG" id="aplc:110980083"/>
    <dbReference type="OMA" id="MNIIVPC"/>
    <dbReference type="OrthoDB" id="10031028at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18989">
        <property type="entry name" value="LGIC_ECD_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19051">
        <property type="entry name" value="LGIC_TM_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000073">
        <property type="entry name" value="Neuronal acetylcholine receptor subunit alpha-9-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034248777" evidence="5">
        <location>
            <begin position="23"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="7">
        <location>
            <begin position="248"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022092106.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="61309" checksum="82FE8F238A648901" modified="2022-01-19" version="1">MCRWTVCLTLLALLECIHPGCPHPRNCPGSAPDEDAYAMLLKTLLNDSTYPEHTRPTKDRTKPTKVQFGMELNAIIDLNEPKQLLKTQITLILNWIDEYLIWKESDYGIPEIRIPSSKVWLPDVTLRNSADSVNFMLEDRLVRVKPNGETEWRAFIVITSFCKINFAFFPYDEQSCQLKFRAWTYPKEQVVFEPGKEFHANDTEEHGEWKIMEMKGSVEEFSEDHGNFSDFIVSIALIRRPQFYVMNIIVPCLIIYCLTLFSFCLPCDSGEKIGLGITILLSLTVFMLISADMMPPTSDNFPLIGQFYTATMVLVAASVGMSVMVLNFNHRPPGARRAPKWMRHLLLQSRCSRLVSLNGVQSFDNLIRDAISQRARGQPGEVTYTLSPSAKTTKSSCLSEDYSASDPLPEIGASMLRYPSSPKLGRPVGCDRPKEAETCVSDKNKNKQTTLDIVSPVGAPRQDSEARDTSPLERLLTNISGDLRKLVEHKEEEKEDEAIVDEWKLLAKAVDRIFLFTFVGSSIILSVVLGSEMMRRKELTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YL63</accession>
    <name>A0A8B7YL63_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein Xfin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110981082</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022093998.1">
        <property type="nucleotide sequence ID" value="XM_022238306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YL63"/>
    <dbReference type="GeneID" id="110981082"/>
    <dbReference type="KEGG" id="aplc:110981082"/>
    <dbReference type="OMA" id="LRYHENP"/>
    <dbReference type="OrthoDB" id="10068874at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002349">
        <property type="entry name" value="Zinc finger and BTB domain-containing 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000303">
        <property type="entry name" value="Zinc finger protein 41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001437">
        <property type="entry name" value="Zinc finger protein 594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000275">
        <property type="entry name" value="zinc finger protein 90 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="704"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="799"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="827"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="855"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="886"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="390"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="899"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022093998.1"/>
        </source>
    </evidence>
    <sequence length="931" mass="107752" checksum="D0DD2FF1B25DCF15" modified="2022-01-19" version="1">MEIASGSMILHPDLASEIIALHESSGFKSLSAFFKHLIALEKQQRSQNSLSTLLELPLLSSSNSNQAVSLGSNQPTVTISVGVQVELCCHRSNGDDVRSHDQNGNHELVSFHQDAPQEDMPSECDNNQSDSNVEADSDSDVGWISGKEFETDNSQRSKWPNRTRKQQLHKPFKLSRKGRKPNRGTNQEFVCEECGAKFTRECYYVHHLKKHRGEETNEQCEYCDLIYPSPWTLTQHISIMHPEHAPPPRDKPPANPLLCKICGMALKNVTTYRNHQRIHTNERPYECSDCHKTFKSTSALLKHGRMHDQVRPYPCHICGDTFKHSSDLIRHQVVHTGEKRYQCIQCNKSYTVNASLKAHIFRHHDHPGVKPFECPHCQRRFVKKDSMTYHIKKKHQHPEQSYRQTDRQRSSYRRRRKTDVHIRMTNVVSQGHKARTESKYVPVLVPAIPLQMSMNWNKKPWTVLYCTGVVKSIFKYVVATWLFGKRPPTLLPPPHNQKGRVKDDHMAHHPSSKGLRLLRITMEIASGSMILHPDLANKIRSLHESSGFESLVTFVKHLFDLEEQHRSQQCLSTLFHAQQTRICSCNTVQVTRSNAEQVRAAVTSVGVQVKLCCPSNKDIVMVSQKQSVNCEQKSVRESHPQKVMVHNSDHDYQCESDHGHAEEPWIEEFEDNGKSHEQDNKTVMEPVYISVVKPKIVKRPCFKFTCEECGAKFTRDYYFTHHMKKHRGEDTAMQCQYCDLTYPSPWTLKQHILSSHDEHNAQCDKPSADRLLCTTCGVTLKTMYTYRQHQRRHTGERPYECQTCHKTFIYSSALEYHKRVHTQERSYPCKFCDKTFRYSTNLKRHQITHTGLQRFKCDQCDKTYRDNGSLKSHILKKHKNPELQVYVCPHCSKQVESKSSLNSHIKVKHQNPEQKTKRTKKLHVRCNKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMM3</accession>
    <name>A0A8B7YMM3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110981326</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022094513.1">
        <property type="nucleotide sequence ID" value="XM_022238821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMM3"/>
    <dbReference type="GeneID" id="110981326"/>
    <dbReference type="KEGG" id="aplc:110981326"/>
    <dbReference type="OMA" id="QCFWGAE"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000004">
        <property type="entry name" value="Peptide methionine sulfoxide reductase A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049006">
        <property type="entry name" value="MsrA_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20939">
        <property type="entry name" value="MsrA_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein methionine sulfoxide reductase A helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022094513.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="22026" checksum="9BC1AF10E4959AF0" modified="2022-01-19" version="1">WFPEAQFGCAKGVIRTRVGYTGGTKKSPTYHSLGDHTETIQIEFDPKQTSYETLLTIFWNSHNSTACTSRQYMSAIFYHGDDQKRLAEKTKEEHQKKVTRQIQTRIKFAETFYDAEDYHQKYMLRHHQGLLKSLNLSSKEMITSHAAARLNGYLGGFGMLKNLELEIEELGLNEEQKEYVRKKVRMGGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMM8</accession>
    <name>A0A8B7YMM8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110981329</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094518.1">
        <property type="nucleotide sequence ID" value="XM_022238826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMM8"/>
    <dbReference type="GeneID" id="110981329"/>
    <dbReference type="KEGG" id="aplc:110981329"/>
    <dbReference type="OMA" id="MEYYFYV"/>
    <dbReference type="OrthoDB" id="10044586at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022094518.1"/>
        </source>
    </evidence>
    <sequence length="214" mass="23346" checksum="25B2E03081D42914" modified="2022-01-19" version="1">MEYYFYVILIFAIVLKLTVYLCWYQVKRSSATREVRIIMPDGTTRCAVISARGWVNQSPRSEERQNLPQAESLAAHDNQGMVECPVQPRYGDALNPQGQLTGPPEYSSQEWKLPKYEEVTGMPPPYTMAEPEATSAVQPVDSIHPVQAQISGPPPAYPGNTSFPASAYSEPSVNESSSFPPQPPTASPVDLATLSSGPHITVPQSTIPSTGHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YNN3</accession>
    <name>A0A8B7YNN3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8 9 10">Zinc transporter ZIP14-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9 10 11" type="primary">LOC110981117</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094058.1">
        <property type="nucleotide sequence ID" value="XM_022238366.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094059.1">
        <property type="nucleotide sequence ID" value="XM_022238367.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094060.1">
        <property type="nucleotide sequence ID" value="XM_022238368.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022094061.1">
        <property type="nucleotide sequence ID" value="XM_022238369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YNN3"/>
    <dbReference type="GeneID" id="110981117"/>
    <dbReference type="KEGG" id="aplc:110981117"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF37">
        <property type="entry name" value="ZINC TRANSPORTER FOI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022094058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022094059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022094060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022094061.1"/>
        </source>
    </evidence>
    <sequence length="486" mass="53101" checksum="194A4CD94F3D1D87" modified="2022-01-19" version="1">MASLLQRIWNGGPSLWLAVAVTCMLLGSSHTSILPGASEMFRAGLGLDLTGGKVRERRHVANESSLMQIIDAFGASGAMTKEQLQKLQTAMNSQCHSVDKLLSYHSLTEEDLLNNTAAALQEICPSLLYQTALHSCSHHDHEDDHHHDHDHGYHEGEEPTTAQVWGYGILCVTIINLGSLMGAFVVPCMDKKVYKLILTYLVGLAVGTLTGSALLHLIPKTYQVHEDDVVWRNTCILAGIYIFFMAERFLKIFSTRKDLNREKKQQDGITHISGMHDMTPHDEPYKITSGDSALGLSDSIPTLETKDAFVQKDNDLTKNGKVHIATVAYMIVFGDGLHNFVDGLAIGASFSTSLLAGFSTCIAIACEEFPHELGDFAILLKSGLSVKQAMAFNFTSALACYIGLVIGIVVGRLTSAEPYIFALAAGMFLYIALADMLPEISNVASKDNFKLSQELKIFLLQNAGILTGFAIMILLSVYHHQIQIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQ25</accession>
    <name>A0A8B7YQ25_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110981789</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110981789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095379.1">
        <property type="nucleotide sequence ID" value="XM_022239687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQ25"/>
    <dbReference type="GeneID" id="110981789"/>
    <dbReference type="KEGG" id="aplc:110981789"/>
    <dbReference type="OMA" id="CISKEAN"/>
    <dbReference type="OrthoDB" id="8942991at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33776">
        <property type="entry name" value="ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33776:SF4">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022095379.1"/>
        </source>
    </evidence>
    <sequence length="763" mass="88283" checksum="A35EFD9F5476A3BE" modified="2022-01-19" version="1">MDIKDKNLLQCSANKVITREPEREPGENPSEVRITNESRYFKSYEFKHKYDQTRNKTTEYLSMICINANNLKYNFDKINDYLEELGYPWDIIGCSETFLKNGDPSLHICHYTFVGNERKDKAGGGVAFFVHNGITFERRKDLTVQVKDCETPCNSLFIEVTGIASRNIIFGVIYSPSFVRKNHMGEFRDSVANVFAKIAEENKVLFIMGDFNINLLDRRYKKFLNAVFNYNYKPLINRSTRVCITETKESRTLIDNIYTNAKYATADTGGILLSAVSDHFPIFQFISLDKVNNAVNWKVSIEDKQAFKTHLKNEIAYKTINGFSLTDTKLVLSRETEKFYRWTSKIKSDYYITKFQNDEVKREIINFINVMIKDKFKCSKPCACICTSEYKMAHMPQSEFTYQYFCGTRKEFVKTPSDGLFTDTTSEEIVELIHQIIKDNSHLSLHRFCPQLITEDLNLTASLSKVFNQSLREGKSPDYSSLHSLKEVVEQWQVWEKCVFPQFDDIFEKIVCKLTKNLLDKNKLTYNNPHLFETQKVNKMAYLVNNVQRALNDKLSPIGVFFSLKRSEIDSGILSTKLKKTGIYGALLNWLSSYFKSRYQNTPSTCNSSLLDLLYANVMTDISNYPIIVNQNEIVIICTNEKKGKKSAWYEKLKETMDNLYKELDENGLSVERCCYIRFRNEENNGKPVQDQTAPKESNEKFKRVEKTTFCGISIDSGVNFHTGDEMHACEEQKVIDECRKRNLLPPEVLTAAQLCCMNVAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQX3</accession>
    <name>A0A8B7YQX3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110981650</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110981650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022095077.1">
        <property type="nucleotide sequence ID" value="XM_022239385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQX3"/>
    <dbReference type="GeneID" id="110981650"/>
    <dbReference type="KEGG" id="aplc:110981650"/>
    <dbReference type="OrthoDB" id="6138508at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050822">
        <property type="entry name" value="Cerebellin_Synaptic_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923">
        <property type="entry name" value="CEREBELLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22923:SF62">
        <property type="entry name" value="CVP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034289705" evidence="6">
        <location>
            <begin position="24"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="303"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="871"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="746"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="797"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="551"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="835"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022095077.1"/>
        </source>
    </evidence>
    <sequence length="1008" mass="113191" checksum="9AE3DEF654A72343" modified="2022-01-19" version="1">MTSSVRQVVFACLLLAVIAHTDARRRRPFIPGKTEPKVTDAPVAVEEFQDTREQDDRNRVLVDMERRMANIEESTSIMKREMLETKSENTRLKEEIQRMSGLMEELDAANGRVGELEWMLSKFENFFGVLYIEHPDFFAREMTVDKRLSALNEYIGNREAELMALRPNPPVVTADPAENPVDEELMGVVIEELSSENAKLKRRLDDMETRMVSVPGNLPDGSRGGPAVTQPDEETRDRLTRLERLMALHFAPQLDEEYPGQNPDSDAGGKRLVSGGSTTQRVPLSESDTEILKEELDSIRSISSTRKSVFSAAATRHVNGEALVHKPVFFDHVFSNKGNHFKEHNSTFICGITGYYFITFTVRSYDNRHLGINMLLNGDRVTSVSGEKDQERNQMMTQSVVLHLSPGDKIWLTVSPATTYAIYSDPGGKYCTFSGFLLFKGSQLGFVQVDSTSNFSNEPTATLANKSGRQRETIMAVSQNKLSYKRLFFIVIVLRAVLAKPSRHTHGEAWPVSGVVPVPPVSGHHSALPHRPWSQGRPLATHRCTCDETRLSQTEQGIADLIRRMEELETQSNEESATLLTLEDSNHRLQTQISRVVGENQRLTRLNRSLQTKSDAMTEENLQLRAQNERLRNKQDQPQPVVDRLVEQVHDDPVQRQRSSLQNLNDIMGNREAELIEMGVFPQMEPATPEGPPIIRPDRRRGSTFSTMAGSASMLPDSEQIATSLLALNQENDNLKRRIGQLEERLNQQGRQPDLMGPAPGMLWPQVRPTSPSGQSSSELAEKISQVERLVLVALHHNPTGPSAGHIMPQPNMEEYPGHQSRPEGPLTNDDQERGSASQPTQTFSVPATDSVLSDDDLEAMADVVDRVRNKSPAKSAFSVASTGVTVGATDDPRAIEFDHEYVNKGGDFKRRRSRFVCENPGFYYVTFTLRSYDNKYLGVSLMKNEELQTAVYADSSERNVMQSQAVILHLEPGDELWLRHAPSEHFAVHSGEHRFVTFSGYLIYRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRR9</accession>
    <name>A0A8B7YRR9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kelch-like protein 12 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022095973.1">
        <property type="nucleotide sequence ID" value="XM_022240281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRR9"/>
    <dbReference type="GeneID" id="110982105"/>
    <dbReference type="KEGG" id="aplc:110982105"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000001">
        <property type="entry name" value="Kelch-like family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF494">
        <property type="entry name" value="KELCH-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="47"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022095973.1"/>
        </source>
    </evidence>
    <sequence length="603" mass="66537" checksum="43B1E62BD608C251" modified="2022-01-19" version="1">MTKMETDQLCSDDGASLEDQRLHSFTGSHCKTMMQTLNRLRKQSLLCDVTVVVEGVEFPAHRVILAACSNYFCAMFTNEMSESTKSSVELKGLKASAMEKLLEFIYTEEVEVTVENVQELLPSACLLQLKGVEDACCAFLTTQLDASNCIGIAKFAESHACMGLLNAAEGYGCRYFSEIVKHEEYLSLEVDEVAKLIKRDDLEVECEEPVYEAVMIWVNHNASERQDLLPTLLQDVRIPLMTPKFITDVLDKEPLIRQSLACRDLVDEGKRFHLRPDCRAEMTGSNFQSRSGGDERLVVIGGFGSQQVPLNIVEEYSPKTKEWHSLPDLSRRRRYLAAVMHSAHIYAVGGYDGSTRLNIVECLKFTQGQPTWVSMAPLNVKRGLPGAAVLNDAIYAAGGFDGNTRLTSAECYDPRIDRWTMIQDMNTGREGAGLTTANSVLYSIGGYDGNSILDSVEMFDSRSGQWSAVASMKVKRSGAGVATINDMIYAVGGFNGSHHLASVECYNPRTNSWSLVASMTTARCYVGAVAIQGKVCAVGGCVYIHVYNQMSFDTRYDGRSLLNTIETYDPVNDSWALEGTMAQKRCDAGVSVLRMSDPRVSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YS34</accession>
    <name>A0A8B7YS34_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110982162</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Microtubule-dependent motor protein required for mitochondrion morphology and transport of mitochondria in neuronal cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096094.1">
        <property type="nucleotide sequence ID" value="XM_022240402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YS34"/>
    <dbReference type="GeneID" id="110982162"/>
    <dbReference type="KEGG" id="aplc:110982162"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22709">
        <property type="entry name" value="FHA_KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000063">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000034">
        <property type="entry name" value="kinesin-like protein KIF28P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="7"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="14">
        <location>
            <begin position="484"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="984"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="895"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="986"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022096094.1"/>
        </source>
    </evidence>
    <sequence length="1059" mass="118385" checksum="509F88C7ECBEF0B5" modified="2022-01-19" version="1">MSSGGESVKVAVRVRPFNTREKDRGAKLVVEMKGATTKLHSLDGEEPKTFTFDYSYWSHDGFTEQPDGILAANPGSNYASQQNVFNDLGQGVLDNAFQGFNCSLFAYGQTGSGKSYSMVGYGPNKGIVPITCDVLFKTIESGDGKVKYEVTFSMLEIYNEQVRDLLQKTNPKGGLQVRQNPKEGLFYVQSLKKVAVGSYREIENRIEEGTSNRTVAATQMNATSSRAHTVVTIQFDQISKNDVGQETKKTSVINLVDLAGSERADSTGATGDRLKEGANINKSLSSLGNVISALADLSMGKKKVLVPYRDSVLTKLLQNALGGNSKTIMIAALSPADINHDETLSTLRYADRAKKIKNKAVVNENPVEKLIRELREENERLKNAMSGGGIVAPEGGVNMTPEEKEKMRQEMMEEIRAQLMANQEAMEDFDWDKKHEQQMQEEDQAVDQKAIVQSRRNKEPHFANLNEDHMLSNVVFHFLGASETTIGRKDADPPPTIMLSGLSISKQHAIVTNNDGEITLRPYSSSCKIKVNGVPLAGARTLEHLDRVMFGSNHLFVFHNPLNPKAPEGTPPVVEWEFAQKELAEARGLMAGGNLTQDQQRTQDQIVELLPMVNEVNAVSEELDKHKSFEIVLLSEEAQEGTNRETKVMVKMKDLLNQNSWLWERGKFINRRYVVQDLYQRYIDGDEDVLKLPKEEDPFWEPPEDVLIGTANVFLQSLGYYLDFDDKVAVTDFKGKEEGSLVVNITPCNQNGQPIGEDEFVDDPNELLGKPYHFKVTVRNGEIHKSRFSHGLKVKYKCYQETDYTWTTEKRDTLSPEWNHSRIVSIPSTTEDVLSYFENSSIKFSVYGRQIDTAPDNKLTKLTTKELRQMENMQDSGRKAHISSTAVEADGQDEVGQIKGELLLLKRKFERLEKKERRLQEICKQWEEKPVEEQQFEPFFRSVSAVAFSTGTKLKTRVHMLNKEDTVSVFSFELEDPSSVKAQQAIKEEPEPAPKKKDDVTPPPCSRAEPQLVPLTNGETAMKGQVPNKGKQDAVNGGKVVQTNGDPRAQGGSKACAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YU62</accession>
    <name>A0A8B7YU62_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Schlafen family member 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC110982602</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Schlafen family. Subgroup III subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096837.1">
        <property type="nucleotide sequence ID" value="XM_022241145.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096838.1">
        <property type="nucleotide sequence ID" value="XM_022241146.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096839.1">
        <property type="nucleotide sequence ID" value="XM_022241147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YU62"/>
    <dbReference type="GeneID" id="110982602"/>
    <dbReference type="KEGG" id="aplc:110982602"/>
    <dbReference type="OMA" id="PETYLYM"/>
    <dbReference type="OrthoDB" id="6052143at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.30">
        <property type="entry name" value="Schlafen, AAA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007421">
        <property type="entry name" value="Schlafen_AlbA_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038461">
        <property type="entry name" value="Schlafen_AlbA_2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048729">
        <property type="entry name" value="SLFN_GTPase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="SLFN-g3_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04326">
        <property type="entry name" value="SLFN_AlbA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21026">
        <property type="entry name" value="SLFN_GTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Schlafen AlbA-2" evidence="2">
        <location>
            <begin position="209"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Schlafen GTPase-like" evidence="4">
        <location>
            <begin position="438"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Schlafen group 3-like DNA/RNA helicase" evidence="3">
        <location>
            <begin position="608"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022096837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022096838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022096839.1"/>
        </source>
    </evidence>
    <sequence length="1180" mass="135132" checksum="F86428F171C65067" modified="2022-01-19" version="1">MATPNKTVPEEIRPFAMNIHIMNSTATTNDDVAKMKLEMEGLLRAVCAALNSPKREVLILRNMDQEKLGLTKRHLDKWKQRIEGELSTKLKTSQWRKCFDFCDLPQDVEYLYCHTTPTPQPTTINFNLRLPTDTSTELVDGYHRVMSILSREAESLSAGRPYFDFDEHLRRADGPHASSSTTSVVTRRGFSHFPGLLDLKLGDTVQTPESKTVQYKKLKDGERLVSNIEKQVSDYFGAFANHDGGWIVIGIENKNYEVVGQTIPKETKVEIERCLDKCARRKIWGRRQEVPVREKHWDVYFHPLGGGKHLVEVRVNPFYGGVFQKAPESYTFEVNDNGEKVPVDMAIDDWMEAMMRQKITEKRRSDEMSHKFEMLSTHICGGCTVFALKNARREIQERMFTIKEGVHIWPETYHSLVHPEVAPFLDSVISALRVKFRSTKGVCVISRCIAVDIGIPRPEDGTNITCDILVFTETETPFLVTLGTAMSSDEGERYSREAAIELEERLTRHGGEGRFFIKSYWYDQLTDPELVPGILESILGHRPQDKPASYHQMHLQKLQAIVAGLVIAIAAFTPETYLYMKDLMGVQVMNLLTPSQLLALSKCKENQYVCIQGYPGTGKTVVGVERAKQLRLDGAQAEEILYIPSNVQMAKYVRDLTFPRSTSLHGSKICLSEAFRDIIQMLKDGSMPENVKYLILDDTQNLLSRRNVPASNVKEDIRHLTPEMRRLAVRETPPIGLLRQENYQVDWLKCLCIWLREKRDNRMVIICDESQSLEKEHYYQTLRQFIKESNGTTVTLNVIIRNSEEITEFFKNFVSTQCYGVLPTTAHDFKGQKPLIRPTLLSPESLRETVKKFTTLSYSPNEISLLRHDRDSDRTALDTCMSTPLQKECMAVYRTINNQLIDLGIEGNGVPGPQVFHAVLFFCLLTKELLERGVRGEQETNFKINLALPCFASKDTACPPFFLRRLLSDRGRYTAPVRDMVVRLFEEKWQYLCELYRAFVQSGRPHFTEAVDILEERKSSLLQPKTKEMTNLQKLYSVSEFLLGPVTVPEHIFRLIDVQHAGFCRLIVFHILPNVHAIHGTHEVPTRGQCIRIESLENFAGRENQVVIGIMPHKDTLERYTFKSYVAALSSRARTKLEILSATAWTFISNMDLEHVRMLKPYFDDQHHEEPNSDTDGRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUC4</accession>
    <name>A0A8B7YUC4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Histamine H3 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982643</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
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        </source>
    </evidence>
    <sequence length="617" mass="67218" checksum="BFFDCC9A9DBD520A" modified="2022-01-19" version="1">MDDLGKAVEKLQLNTEEGDPVSCLDCMLQALEQDGNTVEESSARLLSLGTVAILTEQLKQTDKEISLGRICNIIAEMAKNESIRDPFVDAGIIPTLNGLLSHQDQDVVIQACRALGNICCDHDEARQTIHDTEGVERLLELLKSRSVTPDTDSINQKVRVVASGYLMNLTYANGILQTKVRMQGGIDLLVLLMKNFPDDINLCGKVIMCIGNIAELDENKVGFVNCGITELLIKALKMVGDDDQLETVFEVIATLAENDAMKLEFAKADLVPTVQDVVDNFMKQESAGGSQSDEDFDIERVASDIIILLLTGDESMKYLFNEGQGSLFKMVMSDWIKSPTDLYQISGALAIGNFARNDEHCIKLVELGVLGPLLQLLKRPEGEELDMRLGHAVLSALKNLAIPKVNKPLLLEAGILDVILPLLKLEMHPVVFKLLGTCRMLIDGQGETAVSLGCNAEFIERVADLSDCQIHAGVAGEANRLLAALIKHSANTQVMHCIIEHGGMPRLVAMAMSEHTLMQNEALIALTLLSSTQLDPSAVQALMDANLLGMVSRVLKANTTAPEIQCNVLSLVGFLTQSDVLKEVMIQGDLLEAINMLASSNIEAVRRKAANVREHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWH1</accession>
    <name>A0A8B7YWH1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110983061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
            <location evidence="9">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097663.1">
        <property type="nucleotide sequence ID" value="XM_022241971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWH1"/>
    <dbReference type="GeneID" id="110983061"/>
    <dbReference type="KEGG" id="aplc:110983061"/>
    <dbReference type="CTD" id="51399"/>
    <dbReference type="OMA" id="GQRDGIN"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000009">
        <property type="entry name" value="Trafficking protein particle complex 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097663.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24679" checksum="938AD29B18A8407A" modified="2022-01-19" version="1">MPIYSVYVINRAGGLIYQMDHTQPKTEVEKTFSFPLELTLKIYDERVVVSFGQRDGIKVGHTILGINGEPVRGRQLEDGRDVLEMIANPENYPIAIKFGRPKLSTNERIMLASMFHSLYAIGSQLSPAQKSSGIQVLETDSFKLHCLQTLSGIKLIVLADPKQGGIDALLKKIYEVYSDFALKNPFYSIDMPIRCQLFDDNLKAVLETAERLSMYSSGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXH4</accession>
    <name>A0A8B7YXH4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane prolyl 4-hydroxylase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110982810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022097190.1">
        <property type="nucleotide sequence ID" value="XM_022241498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXH4"/>
    <dbReference type="GeneID" id="110982810"/>
    <dbReference type="KEGG" id="aplc:110982810"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034055093" evidence="8">
        <location>
            <begin position="20"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="242"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022097190.1"/>
        </source>
    </evidence>
    <sequence length="581" mass="65880" checksum="5C669A5D7635560F" modified="2022-01-19" version="1">MWWVLWHILLALAVQVASTSNEDSDILFDESSSPESKERLTLFQLDPVERNHIQDVQLQSGQVLQMRTLAKEPPVFEIPGFLSAEECEHIKKLALEVGLFRSPLKQDGANDETEEEGSAQELFHDFDTNQDGVLDVHEVLEILDLESNVFLRPEDASQMFQEVHLDVDGDGALSLDEFSSVDSEKIIQIKEWAGRLSNDDKKLSRVSQQAWLSQDDGTDKILTDLRQRTTELTGLPAGIVEHSEKLQVVYYTPGGHFHAHYDSEEIDPNQRCSHTAELVPDKGGGHDTRSTRLCRFLTILYYLDDTMEGGETAFPIADNATFSEENVSVETCDLSRHCHEANLYVTPEKGKAVMWYNHYINETTGWLGSMNPYSLHGGCDVIQGTKWIANNWITVDNSYQRQMLYMKEMGLLKLSHRSHPLLDVDDDLPLDPEEADFTDTVYKLKEIWMEYLQNSAGKDALGKYFGSKPSLEDAVDQMMGYTFDHVAEIHLAHNGNEVEYNIVWRTEMDQTATDELDDTDLSSLIQTASAYGRGSGSGVNKMKPSMLRIYKNPRYNADGSKITKQDKVETNLFEKRMSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXT7</accession>
    <name>A0A8B7YXT7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Octopamine receptor beta-2R-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110982969</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022097492.1">
        <property type="nucleotide sequence ID" value="XM_022241800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXT7"/>
    <dbReference type="GeneID" id="110982969"/>
    <dbReference type="KEGG" id="aplc:110982969"/>
    <dbReference type="OMA" id="ISTVICW"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="44"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022097492.1"/>
        </source>
    </evidence>
    <sequence length="374" mass="40886" checksum="65CA4783E5F50405" modified="2022-01-19" version="1">MRSTEHGSSSHGNSSDVSALTLPPVIQGIAQAVLVIVIGLNALGYSWIIITTIRYRQLRVVSNFFLVNLCGAELLFCTVLVPVAFAVVLQGDWDVRPAEINAGIAFICVLILSGFFLSASLWITDKNVKLFKPLAYPRLATLCHFAISTVICWGSALLLASFVFLGLVTASSASVKAVSFPTFILGNWWVLLLLFDGLVVVCVSFITFSNIAVIRLAFKQHRKINSGRLGSVAFVEPASPADRQQDSVFNIQLRPSHLMSRPRIERDAAAGRVNGDLRRQGARTASRRLSFIIYACTFTVAWSPAITLVNLHVFSSIEISSAVIGISAMVAVGQSSFATLVYTLKGQEYRAYLSRQLTHIRRISQIKINTCCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZV5</accession>
    <name>A0A8B7YZV5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110983351</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098237.1">
        <property type="nucleotide sequence ID" value="XM_022242545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZV5"/>
    <dbReference type="GeneID" id="110983351"/>
    <dbReference type="KEGG" id="aplc:110983351"/>
    <dbReference type="OMA" id="WGYCTWG"/>
    <dbReference type="OrthoDB" id="10000543at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd22954">
        <property type="entry name" value="PLL_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22935">
        <property type="entry name" value="SctA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058502">
        <property type="entry name" value="PLL-like_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35362">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35362:SF1">
        <property type="entry name" value="SKICH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26607">
        <property type="entry name" value="DUF8189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034939438" evidence="1">
        <location>
            <begin position="25"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="PLL-like beta propeller" evidence="2">
        <location>
            <begin position="91"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022098237.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="73013" checksum="58C22D43141CDA3D" modified="2022-01-19" version="1">MASLVLKIAIIGLALSSLVTNCGAVSVGGGAAEDCRVFVIRNFLDNTTNTLLAFRVSQGGLQYAKTASQTQPYAWSKWVELGAPPGSKNPSNVSAIASNPVGLHASKNQTQIFVQAGDGQVYTISQELTGTKVAFGKWTKLSPLEYQSGAVLNGQDSVTIGTYKSQIVIFARSVTGKSGLFWCKGDDSGRFSPWNRIGDALDVHLFSDATVIFNTFSGYYEAFAVMNDGYVYRTWQRDDTRWANWRSMGIFQPKVTSKSRPVSNVMSHSFANGVLEVFALGADGTVKHIFQTTCDRVDNPWGYCTWGLWHTLSGKVPPTMGANVIAAGTNVHLGGELFAVDTKGKPWHIWQLERGSSWSDWQQVLTSGPAQPAIIGKPFVSREEKLWWRVFALSGNGTMVVVEQARSLDADPSRVAYGGNLTVSWSVPLDEATNMDWIGVYPAGANNDQYVDFRYVQGGQNPMDNAVPKGKVALESYLPDGKYDIRYLVNRQFVDVIDKSVVYYGGSRDAPWVQVYRGIFRGLGTKTTDFKQCVQDGNKTVATFRESFEAFRNREVYKGLQVFGMGLKDVVETLRVCLETDIAKAVERFVEDLTTCIEGHCEHFVIDALDILLILYEDVYEIFGDIRAASNSFNVASAYEQGGLCIGRVVNVCISLPRQNKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0I7</accession>
    <name>A0A8B7Z0I7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Golgi pH regulator-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Golgi pH regulator (TC 1.A.38) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022098467.1">
        <property type="nucleotide sequence ID" value="XM_022242775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0I7"/>
    <dbReference type="GeneID" id="110983486"/>
    <dbReference type="KEGG" id="aplc:110983486"/>
    <dbReference type="CTD" id="51463"/>
    <dbReference type="OMA" id="FSVYCVY"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051452">
        <property type="term" value="P:intracellular pH reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="11">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="10">
        <location>
            <begin position="278"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098467.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="52861" checksum="E975EE3AE910C966" modified="2022-01-19" version="1">MAFFLDSFVMFTTQIFFFLGGWIFFMRKLFKNYEVHHVIVQLVFSATFALSCTLFELIIFEILGVLNTNSRFFHWKVDLYAILFILIVILPFYVAWFIFTNIRIVQNRHLTFPLTLGAWLVFVYFFWKLGDPFPILSRKHGIFSMEQVISRIGVIGVTIIAVLSGFGAVNCPYTYMAYFVRDVRDADIQAHDRKLMQVMDMILTKKKRILLIERDQLQQASSNRKQAGIWGMLKSVASSSGGANLGQLQQEVAGYEELSRQLFLELVDLNSTKERIEYSKTLQGKYFNIMGYVFSMYCLWKIVICTVNIIFDRVGKTDPVTKGVDIAVHWLGIEFDVTFWSQHVSFILVGIIIVTSIRGLLIKLTKFFYTMSSSKSSNVIVLLLAQTMGMYFVSSVLLMRMNMPPQYRVIITEVLGDLQFNFYHRWFDVIFLISALSSIAFHYLAHKQTPEKQMHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1K5</accession>
    <name>A0A8B7Z1K5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110983696 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098857.1">
        <property type="nucleotide sequence ID" value="XM_022243165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1K5"/>
    <dbReference type="GeneID" id="110983696"/>
    <dbReference type="KEGG" id="aplc:110983696"/>
    <dbReference type="OMA" id="QAFCKTQ"/>
    <dbReference type="OrthoDB" id="10072259at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="639"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="769"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022098857.1"/>
        </source>
    </evidence>
    <sequence length="965" mass="108942" checksum="7EC61023054C197C" modified="2022-01-19" version="1">MFNNQLGTKDLYSTNPSQFLQRSGLRSDYEDSAFNSSLSQSNSQIMSSQVDNSQSSSFDMFSQMMSQQQGFSQQTENSNNPQRFYMKYMSKAPLFNKEPDKNSSSRKKSFQEQLDSNKQKAKESDERDLINTFINLVKECTEEVKSAATDIRKDVDKNLSESASQFGSLIQKINEDLKHYHNTLLGAVKAREDQKTTLDSMQRDLTAKDAKIEVLEAQLAAADQQRDDRVVSSLVEAYTEQQKKNREQMDKMQAEQEAFCKTQLASLQLDQQKYIQRLESERGAAKAREPQMAMARGDDHGSRQAGVSLIPSVTETGHRPRSWQGWPQYQQIGYNDQVMRSYHENPGYQVIPLHSQPNNVSIGPVVIPTSVSSSNHGNCISLTPTSVALSVPHLQNRETYLPTTNQCYQGHNTHDQSSVNQQIGPDIPYLQTGSSSSQENRQSGPILQWGNQAALPLLSPTDASNQHGPWNKLKPSPVAAIAPQVKPREIVPPSQQQCSDESTEEAIINETPQAVATKRKKGQKRYQVAVKTRKQSSRLKSKQGSKPCNRRTSMGLDQENQVMREQHGKQRGVTVPSVDTVQPLQIKKLHHLLEREEDVYEFKEQRGKTVSNAKHKPQGNQDKRIQQIWPSRDRAGKDVQSNKNPSTVQRHLKEQSQKVLHPVPKHPMHSQAVDPLPRTTKRDVCSHTDSDKEAVSAISNKTKAKGKEKSCVKRNMSSEDGIFSQSRISTCTKSRDLRGDGARSSVDDPKVQRENVKISDVTVDGNSSDQEEDESQSPDEDASQELSSEYETKEDSEEQARELIKIQRKNKQPAKRKQLGMLASSPEQHYVSQLDTMPSYSDQEDSSEEMIFSLKLPDSPFLRKAGHNQTENPREREEQVVPMVRRFDILSTPYIQVNRERDTDNESTGTAYSVSVNAGRKLSRHAERKRRLSHYSGSSSSAAMLEITNCLRLQHHKIRRVSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1T4</accession>
    <name>A0A8B7Z1T4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110983634 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110983634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098740.1">
        <property type="nucleotide sequence ID" value="XM_022243048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1T4"/>
    <dbReference type="GeneID" id="110983634"/>
    <dbReference type="KEGG" id="aplc:110983634"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="entry name" value="ADP-ribosylation/Crystallin J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050792">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16222:SF34">
        <property type="entry name" value="ADP-RIBOSYLGLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="ADP-ribosylglycohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034955883" evidence="1">
        <location>
            <begin position="28"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022098740.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="47795" checksum="13156C1134C7A7AE" modified="2022-01-19" version="1">MKTINLPRVVLIGLGGICLTTLQRCLQSTTETVGVRTGNHTEHLKMAQSESLWGLYIGDALSMPVHWYYDPYDIKRDYGDWLTGFVAPKTKHPSSILTISAVGGAGRSGNSKHSDPVIGSVILHDKLKYWQSNKRSIHYHQGMKAGDSTLNAVMAGVNALTLSTEYREHQSLDDGAYGSILAAYVKFMTTPGSHGDTYAESFHREFFKDWVTAGSPVTPEDVLAFAESRSKMLLTTRVDHNIDSIGALVIPVPVIWHCANFSTSDAVKHAVRLVSLTHCSSNLVPFVELFASTLHSVLNGASLREKAHQALESSLLGGSSTWKRVKNYSQRAARYAEGSEERLQVYQEAVSHFGLACYIKGALTSMFFLAYEFHDNFEGGVLTNTNCGGENCHRGAILGLLLGAEAGRIGKEIPQHLKLGIHSSQETIQDLLDAWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3J9</accession>
    <name>A0A8B7Z3J9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110984373</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984373</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100208.1">
        <property type="nucleotide sequence ID" value="XM_022244516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3J9"/>
    <dbReference type="GeneID" id="110984373"/>
    <dbReference type="KEGG" id="aplc:110984373"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032843">
        <property type="entry name" value="Jiv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052317">
        <property type="entry name" value="Viral_replicn-host_int_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44665">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44665:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14901">
        <property type="entry name" value="Jiv90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="464"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100208.1"/>
        </source>
    </evidence>
    <sequence length="726" mass="80800" checksum="536A7C80819D63F4" modified="2022-01-19" version="1">MPLDQQTSNAKKDVTKKGCDANSSSDKDKWPSSTSSSETKELHCNPRASARGAGCNSSTLKPSDNSTSKRISQTKDLPLNSGTSYSYVAWRDQNAKRAMDAVKKSDPAASTETAHNRTFSSADSKSGRQSDAESVQNPGDRPTKVNVSQHTCEEPRLKSEAVTSEVPSESTFSTRGLGNKKSQCPSSGRHPEPTPDTASTHSQDSGLNFRSAPKDDRNRDGFSRTRGSSNEVPSAEPDVRAKESSKPRPMESKTRPDSGVAANSHPHQQRRAEGSTSRASQPGRPASDSASKSSRPGTAQGPRQQSSTRASAARAAPCAREDDAGTRPKDRKREGTSPAGATTDNIDIEDVDPWYKWTRAIGRGLWWALCFAVFLLLILLACLYSTLKVGIKYSWHILRELVKLLQENWHSGRAYQGTSGGQGSRGSSSHGNRSRAPAEPTRSIDIPTSGGEAIKRLLRCNRDNPYEVLGVSSEASEDDIKKYYRRQCMLVHPDKNDLPAASEAFQILQKAYETLTDPVKRREFEMESQHAHFDEEMEDLMKKMEEKMEEVLNTLSCDVCGGKHRRYETNRDPYSARYCSRHGFRHPAHEGDVWVETSHLGFKWHFYAMMEDKIFDITEWAVCQDMKYMEPNSCEVRYRVGTQRSRSAPRQRAPPPGAHGFTNHHSHHRGQEFNDDMAEEMLKEFLRQFHQGDPRGGRAGGPSYGGGDAGSQERGKKHKKHRKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3R2</accession>
    <name>A0A8B7Z3R2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110984401</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100274.1">
        <property type="nucleotide sequence ID" value="XM_022244582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3R2"/>
    <dbReference type="GeneID" id="110984401"/>
    <dbReference type="KEGG" id="aplc:110984401"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF126">
        <property type="entry name" value="NA(+)_H(+) EXCHANGER PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="119"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="709"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="772"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022100274.1"/>
        </source>
    </evidence>
    <sequence length="785" mass="86970" checksum="AA9A3D96451D0A86" modified="2022-01-19" version="1">MEEGGETQQFWGELATMVTSRQHTCGFRITALCVPVLITLLISQSVQFASAGPNATSTVITHGTTGDAHSDNSSDEHEGGESEPHTGHGGVHVASWNLEYVKLPLTVTGFALFVGVAKIGFHHADFLSAIFPESVLLIVMGVIFGGIAFATGNTGSLQSETFFLYLLPPIILEASYSLHDRTFLDNLISILMYAVVGTLINTFLIGLTLYGISLTGAYGDSFTINLIECLVFSSLISAVDPVAVLAIFQEIHVNHVLYFLVFGESLLNDAVTVVLYNMMNSLLSLDSIPASQIVLGFVSFFTVSLGGAAIGIIVGLVTAFLTKFTKHVRVVEPLAILGMAYLSYLLAELFHFSGIISIICCGLAQVQYAFDNISRKSSTTVTYFTKMLSTTTESLIFLQLGQTLWAESHQWNTGFVIFTLLFIFVYRAFGVVVITFIVNKFRITKINKEEQFIMSYGGLRGAVAFSLVATLRVEDVPIRNALVTTTLVVILVTVFLQGITIKPLVRLFRIKRTIGEEPTVSVVIHQTVIDYVMAGIEEVIGHKGHNYFRMWLESLDNRFMKKYLQREPTSWEDEVMKTFEKITNHDHHNHIFKLSRGKECRKGSEPEIEKFKPMLTRGDSYFDSLRRRKPFKKTATGEYTAISDKATPADVAGVIRKNPSHALHEKYDKNLLKDDSQDLPLLMRQRSQEHVLARERILAMSVASKWKKSLRGSKSAETAPETIAEESGCHDGSTGEDDRAEQEKGKKLGEEKEEIGIQGPEDKDPNISVVKADLEINNRDADTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3X2</accession>
    <name>A0A8B7Z3X2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110984442</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022100339.1">
        <property type="nucleotide sequence ID" value="XM_022244647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3X2"/>
    <dbReference type="GeneID" id="110984442"/>
    <dbReference type="KEGG" id="aplc:110984442"/>
    <dbReference type="OMA" id="RYVCHKC"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001046">
        <property type="term" value="P:positive regulation of integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09331">
        <property type="entry name" value="LIM1_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09332">
        <property type="entry name" value="LIM2_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09334">
        <property type="entry name" value="LIM4_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09335">
        <property type="entry name" value="LIM5_PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000011">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000017">
        <property type="entry name" value="Lim and senescent cell antigen-like-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047944">
        <property type="entry name" value="LIMS1/2-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017351">
        <property type="entry name" value="PINCH-1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047946">
        <property type="entry name" value="PINCH-1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24210:SF0">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038003">
        <property type="entry name" value="PINCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6 7 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022100339.1"/>
        </source>
    </evidence>
    <sequence length="331" mass="38528" checksum="4EE8BFF197AA1ABC" modified="2022-01-19" version="1">MSLGGVAICTRCNDGFRQDEKIVNSSGEMWHEECFVCAQCFRPFPEGTFFEFEGRRYCEHDFQVLFAPCCGKCGEFVIGRVIKAMNNNWHAECFRCELCNAVLADTGFVKNRGRALCRPCHLKEKAAGSGKYICFRCHGLIQEDEHLKWKMEHYHPYHFNCCKCGEELTASARELRGELYCLPCHDKQGIPICSACHRPIEERIVTAMGKHWHVEHFVCARCEKPFLGHKHYERNGKAYCEIHYNQLFGNMCFYCNKPITSEMMCTMNKTWCEDHFFCSTCDTLLSAKSKFIEFDLKPVCKKCYDKFPNELKRRQKKVETTSKKYGKGEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5L0</accession>
    <name>A0A8B7Z5L0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydrogenase/reductase SDR family member 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110984756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100924.1">
        <property type="nucleotide sequence ID" value="XM_022245232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5L0"/>
    <dbReference type="GeneID" id="110984756"/>
    <dbReference type="KEGG" id="aplc:110984756"/>
    <dbReference type="OMA" id="WETDANI"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44147:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022100924.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="35291" checksum="14BE507A5C266AE7" modified="2022-01-19" version="1">MTSKPLAGKVCLVTGASRGIGRGIALQLGEAGATVYVTGRSLDPKGEGKPGSLRDAADEIEGRGGKCIPVQCDHGDDEQVKLLFERISKEQNGRLDILVNNAYSAISALLTTIGKTFWEMPVSMWDTINRVGLRGHYVATWHAAQMMVPAKQGLIVNISSHGGLFYFLNAPYCVGKIGCDRMAVDCGLELKKNNVAMLSLWPGPAKTELVLEKWTAEDRTDFEKASYEYVMKYGETIEYSGKVIAHLARDPKIMNKTGRIFITAELGYEYGFRDIDGKAPASLRQVKSLFHWTGHPWLAALTPSFIRCPYWLMALLGNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC77</accession>
    <name>A0A8B7ZC77_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="19">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110986020</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18673"/>
            <dbReference type="Rhea" id="RHEA-COMP:11022"/>
            <dbReference type="Rhea" id="RHEA-COMP:11023"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Membrane</location>
            <topology evidence="1 19">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="19"/>
    <dbReference type="RefSeq" id="XP_022103289.1">
        <property type="nucleotide sequence ID" value="XM_022247597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZC77"/>
    <dbReference type="GeneID" id="110986020"/>
    <dbReference type="KEGG" id="aplc:110986020"/>
    <dbReference type="OrthoDB" id="69842at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004675">
        <property type="term" value="F:transmembrane receptor protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23535">
        <property type="entry name" value="TFP_LU_ECD_ALK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000018">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000064">
        <property type="entry name" value="Receptor protein serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003605">
        <property type="entry name" value="GS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF71">
        <property type="entry name" value="RECEPTOR PROTEIN SERINE_THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08515">
        <property type="entry name" value="TGF_beta_GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SMART" id="SM00467">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51256">
        <property type="entry name" value="GS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="4 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034578260" description="Serine/threonine-protein kinase receptor" evidence="20">
        <location>
            <begin position="22"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="GS" evidence="22">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="228"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022103289.1"/>
        </source>
    </evidence>
    <sequence length="539" mass="61400" checksum="14C6E0D9ABE6DC79" modified="2022-01-19" version="1">MATLRLRCLLVILALEITIYGDNTETTMAEESAKPIFSNETRFECECDDVSCNGENSRCTDAIQCYASLRFDDNGFEYMRKGCFITIQHSHMYCKSEYGEGLVMICCKGDMCNQNILPTFPVPPTTPLPEPRESLPYNVAYLVMAVLGPFLALVIGISFAIFMYRWMHKKRLRELNSSDEGYAHHAPHDLRAVPAGDSTLKDLFDHSNTSGSGSGLPYLVQRTVARQITLVEQVGKGRFGEVWRGNWQGENVAVKIFNSIDEKSWFRETEIYNTVMLRHDNILGFIASDMTSRNSCTQLWLITHYHEFGSLYDYLNRNILDPKMAIRLALSAASGLVHLHTEICCNNSKLAIAHRDIKSKNILVKENHTCCIADLGLAVLHTRKTDQINLGVNTRVGTKRYMAPELLEETMNVAEFESFKRVDVYAFGLVLWEIARRCQVGGMVEDYRPPFFEYVPSDPGFEDMKKVVCTDMLRPTIPNRWSNDQTLVALSKLMKECWYHTASARHSSLRVKKTLMKVAESCNSNMRSKLDYNWEKAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZC89</accession>
    <name>A0A8B7ZC89_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sorting nexin-8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110985615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102445.1">
        <property type="nucleotide sequence ID" value="XM_022246753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZC89"/>
    <dbReference type="GeneID" id="110985615"/>
    <dbReference type="KEGG" id="aplc:110985615"/>
    <dbReference type="CTD" id="29886"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07597">
        <property type="entry name" value="BAR_SNX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06866">
        <property type="entry name" value="PX_SNX8_Mvp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035704">
        <property type="entry name" value="SNX8/Mvp1_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46571">
        <property type="entry name" value="SORTING NEXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46571:SF1">
        <property type="entry name" value="SORTING NEXIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="133"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022102445.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="59680" checksum="2B095B9F08EEF7E3" modified="2022-01-19" version="1">MADDLAYGTVPSFYREVYDIVCPNPADGKVDQDVFIKILVKSSLPKQTLSTIWEAADNKQGYLTRSGLYKALALTALAQQGKPVSEKMLENYGKEELPKPHLGDLSDLRTLSAQVRREKNPNVLSYTYKDLVALDSVTIDLVPEKKGLLLKHVEYEVKSEFFKSSVMRRYSDFDALYDMLISRYPYRMVPRLPPKKMLGANREFIEGRRRALLRFLTLVVRHPVFHSSDVIRYFLTFQGTDMQHRIKEQFRGTPDEYVTSPLALSAKELVPMDTQMQYSNAREHVKRLFASIYQLKHIVDQMALRSAASASDMLLMAKELNMMGSESQVASTWAMGVNESWPKIKTGLKAISVEFAALADKHSVQGKREDNNVAERIALILDLLQAYKDLGDRLEKGLVKDHQNALAKMGSIKKKKMTATVKGSDHVGEVEQLESRIIEQESQIMTMENRNYFSLHCIQMETQLVHANIDILAEVVQALSKTELQGHKEFVGVWEVLATQSPTLSGGEEQAGPKTPTSPTSPAILTAASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZDC5</accession>
    <name>A0A8B7ZDC5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alpha-1B adrenergic receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110985800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102845.1">
        <property type="nucleotide sequence ID" value="XM_022247153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZDC5"/>
    <dbReference type="GeneID" id="110985800"/>
    <dbReference type="KEGG" id="aplc:110985800"/>
    <dbReference type="OMA" id="AFYYNNF"/>
    <dbReference type="OrthoDB" id="5967704at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050569">
        <property type="entry name" value="TAAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24249">
        <property type="entry name" value="HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022102845.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="40016" checksum="FEC29B2BF1DD9345" modified="2022-01-19" version="1">MEEGVDTQTAPNWGMTTESSDNVTALSVFKACVIGVITVFILLGNSMCLIVLRYTHDGVSPVTKLFLISLTISDLLVGVLVGIPVVGSTALQSWPYGDTYCTVVAMCHALYFNAGLSVLAINIERYIAVIWPLRYPLIVTLARAAIAEVFFIVLLMLWTLLYVLKPDRSAFYYNNFSVCFIDADVGHDLTGQLGMTLFIALPMLITVILHLRLFLLATHHASKVSNITLGDINTTSGLSERSESDAEQPAQPSPPAPRREGRARANSDRVSPETKAARTFFIMAVVAAVSWTPYYVTISWENFSNEKVPDAVAFVAQILLLLNSLWNVIIYYTRNDAFRKTANRLLGCCFRVRSSNEQNLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZF11</accession>
    <name>A0A8B7ZF11_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110986583 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104248.1">
        <property type="nucleotide sequence ID" value="XM_022248556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZF11"/>
    <dbReference type="GeneID" id="110986583"/>
    <dbReference type="KEGG" id="aplc:110986583"/>
    <dbReference type="OMA" id="RERMFAP"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056691">
        <property type="entry name" value="DUF7789"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39299">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39299:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25044">
        <property type="entry name" value="DUF7789"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7789" evidence="2">
        <location>
            <begin position="55"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7789" evidence="2">
        <location>
            <begin position="201"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022104248.1"/>
        </source>
    </evidence>
    <sequence length="354" mass="38916" checksum="7F242719ED986563" modified="2022-01-19" version="1">MASPQDYGSTAVMDTSLSIQACPTHSDTDSGHHEERISFSDLGIHQQPSSMETCCGQTRHFSTISCKEWIFLASSTLSILAAAGLTIERLATVPVNSPYFTFSVVVMINICFVLCYVINGVFTERSYEIFIFIVGTLILMIECILNFAVTINSPDMEKYERRVKLTRMIILLVMGLINIIFGAIMSATYWSSTDVVFRCAGALVDRQGVYSRMCFSASMLKIDLQLELSLVVLALKSGQDANPPETVILTLGISYVSIWTVCGVLAMTKDSKRMVYVVLGLSWCEPAYIVYRFVDIGIHWATFSISKVIPAASIVFGIFGLVVRVTLCGALVSVYRNFGKGMKGEAGRGITPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZG87</accession>
    <name>A0A8B7ZG87_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-protein ligase E3B</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">HECT-type ubiquitin transferase E3B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110986369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022103880.1">
        <property type="nucleotide sequence ID" value="XM_022248188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZG87"/>
    <dbReference type="GeneID" id="110986369"/>
    <dbReference type="KEGG" id="aplc:110986369"/>
    <dbReference type="CTD" id="89910"/>
    <dbReference type="OMA" id="NTKCTAP"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000012">
        <property type="entry name" value="Ubiquitin-protein ligase E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF3">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="12">
        <location>
            <begin position="714"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022103880.1"/>
        </source>
    </evidence>
    <sequence length="1079" mass="122695" checksum="02DA60166ED79A2F" modified="2022-01-19" version="1">MFCKTEASKKTELLEKAKASRNERAQHKQREQASVKIQAVVRGFLCRRRYRRWMLESLDSILEASCVSSSASPSSPQPVQSQTATKQQFRSAQDVFPAVRKFLMVYVDDLDRQRFEKLCRYILAGMDKGDPKVWYVSLALSKDHVLPWIRQLKSILDLCCTKLRRLKPESPVDAKIITLYLHMLVTFTDTTTWKILKVQGAEALRPSLNQLCSNVMGYLNSHGLFPMLQQLLVEGVARKKPCLSNTMLSALFTIALRPVIASKYSDNLASLFHLYVLSVPAMVLHLASTAPKCIESIKKHNLFKQSLDFLAKEQNTKIIFNVLEGNYALCLLANLVHLGQLEQQVLSSNVQTFTRVTVSLLTHCQSYVGKKMSLTTQWHPVLGWFSQPTDHRLHEAMVYVVKQLNMLWDQQILQLVFLDILKAAPEPDSSAKSPTSSAKTQSKGGSFLKRLQRTTSKLGTQKGGKSLQSAEVIAVCNVCDMYQTAIATLIELRRDILTGLSYRDLLLPRLWHFIAELGPHGGLKLFQECLCSVDSHNILSVLVLFCDVASYLIPILDDIEFYDQQIPFHQDDLVAVTAFLNAFVFKMIWEHGVGGTVKQASLFNSTHSLLHLLYDRDCRRQFAPSNHWLIKDLKLTTFRAELEKGSKRTTLILQKMPHVIPHRERVMLFRKRVAEEKKALGFTETASHSPHSTLITVHRTRLVEDGYQLLAGLPAQTLKGLIRVRFVNMQGLDEAGIDQDGVFKEFLEEIIKTVFNPTLNLFKTTSDQHLYPSPTSYINENHLGLFEFVGKMLAKAVYEGIVVEVPFASFFLSQMLEQQHNQLYSPIDELPSMDAELYKNLTYVKHYEGDISDLDLVFSYDEDVMGKIHTHELVAGGKAVAVTNENKISYIHLMAHHRLYRQILDQTKAFKRGFRSIINPEWLSWFSGPELQRLISGDNAEIDLSDLRKHTQYYGGFHNSHRVINWLFDVLANEFTAQERAQFLKFVTSCSKPPLLGFAHLEPPFSIRCVEVSDDQDTGDTVGSVLRGFLRIQKRDPVGRLPTSSTCFNLLKLPNYQKKATLKEKLRYAITSNTGFELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGI5</accession>
    <name>A0A8B7ZGI5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5 6 7">Kelch repeat and BTB domain-containing protein 8-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6 7" type="primary">LOC110986839</name>
    </gene>
    <organism evidence="4 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6 7" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104765.1">
        <property type="nucleotide sequence ID" value="XM_022249073.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104766.1">
        <property type="nucleotide sequence ID" value="XM_022249074.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104768.1">
        <property type="nucleotide sequence ID" value="XM_022249076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGI5"/>
    <dbReference type="GeneID" id="110986839"/>
    <dbReference type="KEGG" id="aplc:110986839"/>
    <dbReference type="OMA" id="FWMYDHA"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632:SF3">
        <property type="entry name" value="KELCH-LIKE PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45632">
        <property type="entry name" value="LD33804P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022104765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022104766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022104768.1"/>
        </source>
    </evidence>
    <sequence length="600" mass="67632" checksum="15ADFFC9F66A777D" modified="2022-01-19" version="1">MMAGVETKTITSSKNCHDSLQALRTFQDSDVIRYADSNHSNMLLTGLSHLRREKLLTDVTLQVGREKFSCHRIVLAACSPYFKAMFTGGMQESTGSCSVVCLGDVEPLSLQLILDFVYTGAISLNNDNVQNVFSAANLLQVAPVVHFCAEYMEKNLHVMNCLDMYQLACTYSCANLKEAAWDFLNYHIQDVVNEPQVVHASIDVINDIVRSNQLNVASEDTVLKMVLTWLQWDLITRKVFMTGLLENVRLQHITHDSLHSMTTVDMEPEMMCAVQDAVKVCKEAFHSCKESNSSQQKLMQRLGMSAQEVLLLIGRSCTEHTLCCYHPPSQTSFFINLPPVCRTFGAKLVVTDANDIYVATDDYREKSIFRFNHIQAKWVEMSPMLQGRSNFAFVTVGGKLFALGGLNDWEILRSVEWYDPARDEWQFASSMPRDVIDFSAATCKNMIYVFSGSRTMRYDIHTDTWIATLPPMPTPRLQAACTTNGSEIWLIGGFLAQSSSEVPTVSVESFLPESNSWTKKEPLPSLLRFCSAVRYEAGSKLYLCGMWCGVHEMGLNIPMQLSSQFDLYDFDELTNCWADIAFDIPMQEVESCASARVFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGW1</accession>
    <name>A0A8B7ZGW1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neuroendocrine protein 7B2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110986870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 7B2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104829.1">
        <property type="nucleotide sequence ID" value="XM_022249137.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104830.1">
        <property type="nucleotide sequence ID" value="XM_022249138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGW1"/>
    <dbReference type="GeneID" id="110986870"/>
    <dbReference type="KEGG" id="aplc:110986870"/>
    <dbReference type="OMA" id="MPFKRNQ"/>
    <dbReference type="OrthoDB" id="9922675at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046883">
        <property type="term" value="P:regulation of hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007945">
        <property type="entry name" value="Secretogranin_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12738">
        <property type="entry name" value="NEUROENDOCRINE PROTEIN 7B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12738:SF0">
        <property type="entry name" value="NEUROENDOCRINE PROTEIN 7B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665718" description="Neuroendocrine protein 7B2" evidence="9">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022104829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022104830.1"/>
        </source>
    </evidence>
    <sequence length="244" mass="26645" checksum="1F959EA343CA8D86" modified="2022-01-19" version="1">MNFPLLVLSSALFLVCSAYPFSSSDRLALRSYLRDALLGDIGDAMVGPATREESAANNKLIVPPNTFVSGGAGEGKQHLGSLGKIPNKQVAIPEIHSGYSTPPNPCPKTMDEAGKDSVKSLMHPRLTCFCEPGWQDDQLESLDCTESDKCCLATMSNTAAFVSQYQETGEAEEQQYMPFKRNQYIQGEKRGQLVAKKSPEIISKRSPGLRRPATKRFNPYLDDQPRIQGVVAKKSPGLSSFPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHE7</accession>
    <name>A0A8B7ZHE7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Sodium/potassium/calcium exchanger 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110987008</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105073.1">
        <property type="nucleotide sequence ID" value="XM_022249381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHE7"/>
    <dbReference type="GeneID" id="110987008"/>
    <dbReference type="KEGG" id="aplc:110987008"/>
    <dbReference type="OMA" id="FLREREF"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF8">
        <property type="entry name" value="INNER MEMBRANE PROTEIN YRBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0915">Sodium</keyword>
    <keyword evidence="16" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="10" id="KW-0769">Symport</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="610"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="18">
        <location>
            <begin position="122"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="18">
        <location>
            <begin position="465"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022105073.1"/>
        </source>
    </evidence>
    <sequence length="637" mass="69979" checksum="95CE2C83E5D2008C" modified="2022-01-19" version="1">MKKSFLYSSVMETKGLYPCLASTQAAGCCRRTIPRTMGARRHRRRPSARWVIRTGLLLGVFAVSTLYFVAFGRGSISDEAAGHSGYRSRHLLSTGNKTGHGIDSCDYETQHVTALFVVVYTILILIFFISLAIICDDFFVPSLEIISERLELSEDVAGATFMAAGSSAPELFSSLAGVSVESDVGVGTIVGSAVFNILIIIAMSAALAGQVLQLDWRPLLRDSIWYALSIACFIVFSWDGQFELYEAIVLLVLYGLYIVIMKFNTSIMDLMSCNKCRKTKVEPLESGNGQDDQAGSAKVTPDDAAFTPAVAAEKQMSHADRKLSIISTASGGGLPRSSSSHKHIFHHVKHGELAANFASKRHSITVVHHEHPVLPAVPPNAEDDTPAKQDIIEEDEVIDEELTLRPIPCLPAISMYYPDREVMQSRCGYLRYALKWLMFCISFPFMCAFTWTIPNCSNPKYKRFYILSFVLSIVWIAILSFAMITLVTKVGCILSIDAYSMGLVFVAIGTSVPDAISSILVARDGFGDMAVSNAIGSNVFDIDLGLGLPFLISIIIFNRPLNLLTQEESDMLATGALLMTPHAKFGFILLGILVLTLIVFACVRFKLNRVVGVTFVAVYVLFLIYAFLQELVCKYIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIF8</accession>
    <name>A0A8B7ZIF8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fatty acid desaturase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110985906</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103051.1">
        <property type="nucleotide sequence ID" value="XM_022247359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIF8"/>
    <dbReference type="GeneID" id="110985906"/>
    <dbReference type="KEGG" id="aplc:110985906"/>
    <dbReference type="OMA" id="CGWWMHE"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF88">
        <property type="entry name" value="DELTA(5) FATTY ACID DESATURASE FAT-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022103051.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="51398" checksum="6BDBD427DF9D14D9" modified="2022-01-19" version="1">MGKGQQGQVMSPVGKDITYTWDEIKKHNGRYDKWLVIENGVYDVTHWMSKHPGGFKVLSHYGGEDATEAFVAFHPDKKLVRKYMKPLCIGTVEDKSPKSKLVTDMEALRVKAEAMGLFKANMWFYAAHLGHILAAEVLAWAVLWCFGVGWLPYLLATVLLTVEQAQSSWFLHDLGHLSVFRKSRWNHLLQYFVTGALKGASCHWWNYRHYQHHAKPNIIRKDPDIKMPYLFVLGDKQPVTWGSKKRKYVLPFNYQQIYFFFTLPPLLMTLYFHYEYFAHVIRKKLWKDLAWMSVFFVKHTLLFGLLLGGWGVFLNYMLIKFLESNWFVWTSQMNHIPMEIDHDQRKEWLPAQLHATCDVESSFFNDWFTGHLNFQIEHHLFPTMPRHNLHKIAPDVKALCEKHNICYQTKSLSQAFADIVRSLKHSGQLWYDAYHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIV8</accession>
    <name>A0A8B7ZIV8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PX domain-containing protein kinase-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Modulator of Na,K-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110986930</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022104952.1">
        <property type="nucleotide sequence ID" value="XM_022249260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIV8"/>
    <dbReference type="GeneID" id="110986930"/>
    <dbReference type="KEGG" id="aplc:110986930"/>
    <dbReference type="CTD" id="54899"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043271">
        <property type="term" value="P:negative regulation of monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22062">
        <property type="entry name" value="WH2_DdVASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000010">
        <property type="entry name" value="PX domain-containing protein kinase-like protein isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000830">
        <property type="entry name" value="PX domain-containing serine/threonine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF40">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="149"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="13">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="429"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022104952.1"/>
        </source>
    </evidence>
    <sequence length="574" mass="64329" checksum="6C3496F00A39E6B8" modified="2022-01-19" version="1">MSLFEKRKSSKVLLDDTTPLQCMIEAAQNVETHIDYVIKVQRGIAPEKTWQINRRYSDFVTLHELLKITNLELPLPPKKVFGNMDREFIAERQQSLQQYLNLILSHHLLATSIIIKRFLDPTNYPTNLQEVALQHVSMFFRSEPYWEVVEPFRDIGWRIRKSYFLIRPKDQPKVRQILAWSDFGPDKVMEDKDILQAMKVLPTIQHPYIYPVTFASANETGGFAIRTYHATGTLRDFICKSKPKHHYLRKYCHPKSYTAFNLMNIKTYGRQILEALKFLQEKGIPYGHLHTGNVILEGNTCRLVDIENSVLGLPCYYRDFIVQHKKINTTEAIDVYSFGHVIFEMVFGMPLNKHFKDDFPHTVPPPIKSVLESILTSESCKSGLPTVDDLIADPLFSDVSVATAPQFRLSSKLKEPLKMAKEIGVEKRLKADQKQLSSWRRASKAHAHHNSEEEKKKRKKASAKKRLSEQQLSVTEGETNGATNSSTNGTASGVSSPSSTAPSSPSSVPQPPPLPVAPGSPGALPPPSLSAPGSPPPPEPAATGERGALLSSIQSFSKGALKKAVTKDCSAPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIX5</accession>
    <name>A0A8B7ZIX5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110987299</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110987299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105593.1">
        <property type="nucleotide sequence ID" value="XM_022249901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIX5"/>
    <dbReference type="GeneID" id="110987299"/>
    <dbReference type="KEGG" id="aplc:110987299"/>
    <dbReference type="OMA" id="PFSENTW"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000128">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000127">
        <property type="entry name" value="Thyroglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="25"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="628"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105593.1"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134227" checksum="FCD8C93CDEDF1427" modified="2022-01-19" version="1">MMDTFKGVIFSPFVLLASFYIGVADPVVNVSQGMLLGRTENFVERLYLRVNVDIDVYEGVPYAEPPKRFRPPEERHPWNGVWNATYARNRCAQPIIPSSEDCLYLNVYAPENAKQGAAVMVWFHGGGYQYGFSTSPTYDPIVLVALANDMIFVSANYRLGLYGFLSTGDAASPGNYGLMDQLEVLKWVKKNIAVFGGDPSRVTIVGESAGAGSVSAHLLSPHSKGYFHQAIMQSGNVLSPWAIDSSLNSKRSLVMAKDLARRVECPTDSNIEMVACLRQTPERTLNAQERQLLSDTVFNDLPFKPVIDKDFIPDQPEVLLQRGSLNPGNLLMGSNRDEGTLFALRAYLRDYLNADEAPKIPLRDFRELLPLYTYSYNRPLLLSAMEQQYLDWSVADNATADHFQSFVAIMTDMAFACPTDAFARSAIASDNRTVYMYHLTHVPTKSLVSLGGLGPKWLGVGHAEDIPFLFMFGLNPDRLFSQPAVDKQLGIQMATYWTNFIKTGNPDGSSLPSANSWTPYWPPASPVYKELSPDMKNGRSLKANECAFWNSYIPKLAAFTANSTALEEEWAVEVDRWRNQDMPSWLTAFQDFNEREEFFIRRTEPRTKMNLCVFTCLLALAGAAMAGPLIQTRNGRIEGVTETFKEDKYLKVDKEIDIYRGIPYAEPPVGHRRFQPPVPVNSWSGTLNAARHGPACIQYFISFSGMDEDCLFLDVYRPHTVSKTAAVMVFIHGGAFFFGYGSMPEYLGQPISAVGDVIYVAINYRLGPFGFLSTGDSAAPGNVGLLDQVLALKWVKDNIQRFGGDPDNITIFGESAGGASVSFHLVSKHSRGLFKRAIMQSGTSTSFFAYQRSLDYAKNQAKEVGLKAGCPTGTTAEMISCLQALPARELRSVAYKVGLAYLPVVDGSFLHDKPENILAAGDFQKLDILIGTMQDEGSLVALVENLFSFFASKAPPMSHDEFLKTYPGWIYNYGDVANNTAMKQAIETRYVSDSQAADPASDYLDNFIRIMTDYIWIVPTEVTAQAHLREGNKVYMYQMTHTPTVSIFHIFFLGPKWVGAIHADDLPFVFGNAWIPKVFYKSTKPLPEERMMSNTIMKYWTNFAKTGSPNDGVVPNWPEYNLDKKQYKDISVYFPTKSGGIRQDYVSFWTNDIPKLVTRSDVISDPTRGIEAFFEVFNLVEQCKAQFDENGLYIRQEKSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJQ3</accession>
    <name>A0A8B7ZJQ3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110987025 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110987025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105110.1">
        <property type="nucleotide sequence ID" value="XM_022249418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJQ3"/>
    <dbReference type="GeneID" id="110987025"/>
    <dbReference type="KEGG" id="aplc:110987025"/>
    <dbReference type="OrthoDB" id="10517560at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="239"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="257"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022105110.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="36345" checksum="2E4E714BBAFDBFA6" modified="2022-01-19" version="1">MRNNLISVKEGNLEFPVPERRFSKSFSTSRTFLSGLCVVKRMKTFDLRINQISRWTKICDDVRPSSNHNTVRNCIGTAVFHKGGTSSYRISPTKFPASRMSSSASKLPTGSRRSLWRSVSNENQDVQGAAIVPRHLFGESSYDGDAKHLIDKGFPQRKAACLQPLQSNGNGAGQHGSLYRSISNDSEQSDADFDLLPLIKEELRNNIQKRRWQRGVLDLALEDYDKEKYQDDQLTPEEQAKREDRKNRNREAAARCRAKRRKHMEELEQSMVNLESRKNELIQQKEQLLREKRELEKMVDDHFRLCPCNNEMRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKI5</accession>
    <name>A0A8B7ZKI5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pancreatic lipase-related protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110986343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103826.1">
        <property type="nucleotide sequence ID" value="XM_022248134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKI5"/>
    <dbReference type="GeneID" id="110986343"/>
    <dbReference type="KEGG" id="aplc:110986343"/>
    <dbReference type="OMA" id="CGNYESA"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF178">
        <property type="entry name" value="LIPASE MEMBER H-A-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034878150" evidence="5">
        <location>
            <begin position="26"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="6">
        <location>
            <begin position="51"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022103826.1"/>
        </source>
    </evidence>
    <sequence length="340" mass="37923" checksum="01C9100C8A8F161F" modified="2022-01-19" version="1">MSGLHCHLITASLVISLMCIMEVCTEVCFKDSSDAVNSELCFSNRLGCWAEDPKLYPRKPSEQDNHFFLYTRNNADSVELKWDDASSLGAFDAQRRTVVVAHGFRSSPDRKGFKGIREAVLRESDVNVIMVDWRKAAAGLLKYPQCRVNSRLVGRQLGILLKLLHDHRNLDYAHVHIVGHSLGAHLSGLAGKYLGGQVGRITGLDPAKPDFKDYTHIPDCILDKTDAQFVDIIHSDRGHSVYGLQTAIGHQDFYPNYHKFNQIGCNYFNTLTGCAHTRAVDFFIASVEHLRDPSTECDYSTKPCDGSNCPSSGCPKMGIEASPTGEEPKSYCLKTKCYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLW6</accession>
    <name>A0A8B7ZLW6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987549</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022106052.1">
        <property type="nucleotide sequence ID" value="XM_022250360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLW6"/>
    <dbReference type="GeneID" id="110987549"/>
    <dbReference type="KEGG" id="aplc:110987549"/>
    <dbReference type="OMA" id="NSWFKSG"/>
    <dbReference type="OrthoDB" id="4255at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12937">
        <property type="entry name" value="GUCT_RH7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001168">
        <property type="entry name" value="nucleolar RNA helicase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059027">
        <property type="entry name" value="DD_DDX21-DDX50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050547">
        <property type="entry name" value="DEAD_box_RNA_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012562">
        <property type="entry name" value="GUCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963:SF8">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47963">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 47, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26142">
        <property type="entry name" value="DD_DDX21-DDX50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08152">
        <property type="entry name" value="GUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="179"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="464"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="503"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106052.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="57894" checksum="90A2AA503F4D9B65" modified="2022-01-19" version="1">MALAPTRELAKQVCEEFEAISPSLTTCCIYGGVAYWPQESALRKGIDVLVGTPGRVLDYVRKRTLDLTRLKHVVLDEVDRMLDMGFAESVEEILSAVYSVRDPIDRASSASEEEHPTNPQTLLFSATVPSWVHNTARKYMKQELRKHDLVGTQSVKTAKNVKHLAIRCNYSDRPSLINDVIRVYSGLNGRSMIFCETKVEANELSMNPAMKIDAQVLHGDIQQQQREITLKGFREGKFQCLVTTDVAARGLDIPEVDLVIQCSPPRDVDSYIHRSGRTGRAGRSGICVCFYKPQEEHDIRRVENQAGMRFTKTAPPQPEDIIKASSAEAAKSLGAVPATIADYFRLAARELLEETSAEEALATALAYMSGATELKTRSLITAQQGQITYLLKTNYKMYSTQDAIQALGFQLSKDIKSAIREVRVCKDMMSAALDIPQNLENRLLKQWQNSPDCSLTCATELPDIIPSGGARGSSRFGGGGGTRRWGGGGRDRRGGGRGDGRRNGGGSRSGRRGGAGGRRSGGRGHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM42</accession>
    <name>A0A8B7ZM42_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110987868 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110987868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106688.1">
        <property type="nucleotide sequence ID" value="XM_022250996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM42"/>
    <dbReference type="GeneID" id="110987868"/>
    <dbReference type="KEGG" id="aplc:110987868"/>
    <dbReference type="OMA" id="FDMQINP"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000906">
        <property type="entry name" value="ZU5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF2">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00791">
        <property type="entry name" value="ZU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="4">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="132"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="259"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="856"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022106688.1"/>
        </source>
    </evidence>
    <sequence length="993" mass="112393" checksum="9BDD66879C63749C" modified="2022-01-19" version="1">MAINAQRLRELPGNDRCADCQDCDCQECGFPDPVWACEELGILVCEECMDLHCVLSNATFKSIICQDWTEESYKKMASTNNNASKEIYEKHLCPAYKKPTRCFNIEFRKQWITAKYLRKEFVSAENQPKYMQGKKSGYLWKLGRDSQVFQRRWFVLDPSGKGTLRYYTDANEQSLRGEISLFKMNMVLASPEKIGHPNGLQIVYPDNKGQNTRMIYLYAEMAKDMVEWFQAVRCLKFFIRKSTSVDKDEDIISRILKYDILKEGYLLKTGAKGKEAFRKRWIVLDKMCLMYFKEPLDANPKGTIPMKGGYSLILSGQLDPENRGFHFYLKTPGRIYHFIADSDHERKAWFNAIHAACNRASGVCSKNKGPTLAGGKWVTASSPPTQVESSHKTKENTSSPEGSASSTSRESVLDITKTAKASPGPGGEDSSDVDDNFVALSAPFAGVRPSTKPRPQHTLADYHGRGHGRGGGGAHGRYHHAELKHQPAVEVAEGVTEEDPYIEFTTEEDETLEPEEDTEDSSDDEEESPYIELDGEKVVMMQKVDMIGMTTKQLSTHLKVPRKALPQSSSCTMCVSLVWDTLPNLPDSEGYVLVSPIVSCCSMPRDVALLQPFQLEIQHSAILKDVANCKPMIWHLQKDPGKFFKWEKADQGSFNMTCRAFYRNFLIETTRTGCFAIMVPSESISGKLIRCMTYISSEQGDDHLVARVYFFGDNGSDDVLHEIQRRENTYRGRLCDISCSFFLANTEDNILMNMSELEGMELYFGGNEPMTITSEEVWQKQLVCYMAEIIKKNPTGQCTINVWQENTDAEKYPIQMNLQFSNEEKYPVIAPVPYLHTHLPQPTTVPVRCHQAVSRVSSAPLAQRPSPSLIADRPRDTPHARSVPSRSRAADAVASTCLQDNMLPFAVKRDLFLLLDTKVATGNDWRMLASQLGLDAMIYCFDMQINPTMEVLKAFETMNRPLNELEEHLRLIGRDDAADIIKTYLEKTRKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM69</accession>
    <name>A0A8B7ZM69_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipase</fullName>
            <ecNumber evidence="7">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13 14 15 16" type="primary">LOC110987506</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022105984.1">
        <property type="nucleotide sequence ID" value="XM_022250292.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105985.1">
        <property type="nucleotide sequence ID" value="XM_022250293.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105986.1">
        <property type="nucleotide sequence ID" value="XM_022250294.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105987.1">
        <property type="nucleotide sequence ID" value="XM_022250295.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105988.1">
        <property type="nucleotide sequence ID" value="XM_022250296.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110987506"/>
    <dbReference type="KEGG" id="aplc:110987506"/>
    <dbReference type="OMA" id="EPQNYIS"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
        <property type="term" value="P:regulation of vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="370"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="753"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="9">
        <location>
            <begin position="1157"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="810"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022105985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022105986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022105987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022105988.1"/>
        </source>
    </evidence>
    <sequence length="1341" mass="152194" checksum="B1AF4E82D6F6FA1F" modified="2022-01-19" version="1">MDQDAEPMISANDSVDMLDVDDNYIANYGTFGIDENEGDDYSRDDSGKAHEGEDTDDETQKLVVTGKRGRKRGDSGASLKRGMVIDANSQRDEENVITNGANMEAELEDNQHIEAKTDEDENAGKRDKIVEVMGGALTGDVDDGEIELKVVEDDGEATGEDGDKRQEEKEERHDYAEDSDDVRTCEPENVTMETVISDEDRETDPSTMSAVSEEQEDQTDAAPKRSSQTLAISISMVKMMKATEPSSEGVQKPIPPEQIVLQQLKKEKDSSSCYDDGACKDTEMERVRAYSKNQGHQSISRPKDFHRSGSLFSDPSGRESQALEWEWIEEPDLQDDTDSPDIHMRSFASVHSEPKGFREVGRGVFLPHQKLEVTVVDCGRSSSSQFINPNLYFIEVKHGTCIWTIQRRSNDFLKLHEEMLLYKARLAIPIGDRGHLQRRRTFKANRDRDLAHFPRTPDAFVRAQQLPKRMHQYEVYLKSLVRNPLYRNHPQTLEFLEVSHLSFVDELGPKGKEGWIQKRSGGHRVPITRCCPCLVCTDCTSVAAHYSKRWLVTKDSFVAYVRPSDGHIRAVMLADADFDAKWGIEETNLNTGLIISNQYRKLLVKCDSVQMARHWMVEIMEMISKSEYTEERRFSAFGPERTDTYARWFVDGSKYFDALADAMEGAEQEIFITDWWLNAEIYLKRPAVEGPHWRLDNILRRKAASGVKIFILLYKEVDVALDLGSKHTKHVLMDLHPNIKVMRHPDHNPGQVILWAHHEKLVVVDQKVAFVGGLDICYGRWDDFKHRLADTGSALVANKNASLPRQQMDLFMKPPNIDPDPTPGPKVHIKSNEVDYVGDDSDDDIDGRPPPSPRTPTSPEPEDEGGYFRRPRLKSATAYLMNPIRRLRQEETQTSVDENLDKLGLSGTPKLWIGKDYCNFIAKDVLAPEESLQDSVDRMKTPRMPWHDIGTCLYGRVAADVARHFIQRWNFTKKEKAERLNHYPLLLPKSTSSIEVKEEHKTNSVPCNCQLLRSASKWSVGVKHTEDSIQKAYIKLIGEAKHYIYIENQFFITLPDSEVTNGIAQALYQRILRAYEERETFRVYVFLPLLPAFQGDVGEAGGGAIHAILHWEYQSICRGSKSLIGRLMKAGVSDVREYITFYGLRTHDTLNGELVTELVYIHSKLMIVDDRAFICGSANINDRSLLGKRDSELAVLVEDTEMIPSRMNGEEYMAGKLAFGLREWLFKEHLGVLQGHGEIDMTDPVSDSFYKGVVMKLASDNTVIFELVFRCLPSNSVTSSAVLQEFKKVTPLCKTDPKAALRLLKDIHGYITWIPLDFLKDENLQPKLTSQEGIAPTKLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZN73</accession>
    <name>A0A8B7ZN73_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14 15" type="primary">LOC110987690</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022106344.1">
        <property type="nucleotide sequence ID" value="XM_022250652.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106345.1">
        <property type="nucleotide sequence ID" value="XM_022250653.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106346.1">
        <property type="nucleotide sequence ID" value="XM_022250654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZN73"/>
    <dbReference type="GeneID" id="110987690"/>
    <dbReference type="KEGG" id="aplc:110987690"/>
    <dbReference type="OMA" id="LANACWW"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF166">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022106344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022106346.1"/>
        </source>
    </evidence>
    <sequence length="290" mass="33867" checksum="B8C7C896ADA6415C" modified="2022-01-19" version="1">MVGVVEYIKSKVAWAESVADPRTKDWFLMDSPVPSYSLVMLYLMVVWWGPRYMADRKPFDLKYIMMAYNLALVVLSAYMFKEFFVTTILNPNFNSVCQAVDYSEDPMALRLAAVCWWFFFSKVIELLDTVIFILRKKNSQITFLHVYHHSTMVLLWWIGVRWVAGGNSYSSGMVNCLIHTLMYSYYFLSALGPSVQPFLWWKKYLTSLQLLQFFGIMIHSFVTLYLDCGFPDPYVYALIGYLISHIILFSNFYRKSYGNKDKKKKSGDATSEQEQAGGRRYNLRQRSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP91</accession>
    <name>A0A8B7ZP91_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110987092</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105216.1">
        <property type="nucleotide sequence ID" value="XM_022249524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP91"/>
    <dbReference type="GeneID" id="110987092"/>
    <dbReference type="KEGG" id="aplc:110987092"/>
    <dbReference type="OMA" id="EVKRKWH"/>
    <dbReference type="OrthoDB" id="3066195at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028002">
        <property type="entry name" value="Myb_DNA-bind_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098">
        <property type="entry name" value="AGAP001331-PA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23098:SF16">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13873">
        <property type="entry name" value="Myb_DNA-bind_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022105216.1"/>
        </source>
    </evidence>
    <sequence length="387" mass="43044" checksum="22632890997FC751" modified="2022-01-19" version="1">MMERYRVPKRKPNWTDAEHTIILDAYEKHKAVLASRETSFLSCHEKSKCWMEITKQLNQLNPAVRRSVEEVKRKWHNLLGQGRRDFFDWKRAQQDPTLPPVVMPAISRRALELHGGFKFEDLQNRQDGEEFVFIDASSSDIVEDQVVDETTDAPDDITPEMMSTPPQDSVKEECPSPLVIEDSCEASSYSTSSIPNASPPPLPVPTQTAVFWTSTSSHPSMTPAPHIQSTAVTLHAAQASHATGLTTTGARNRFSPHLNSAPSNPSPHRLAAPTSGSLNHPSVTSPVSVATISHTSPGVGVPSSFVEPTSLLGQVTIQPSESARKKFRGSSQSERSERGTGLNAEREAELRIDILQLEKEKLWLETEKLRLEIDILRKQKQKMNSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPN0</accession>
    <name>A0A8B7ZPN0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">EF-hand calcium-binding domain-containing protein 2-like isoform X1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">EF-hand calcium-binding domain-containing protein 2-like isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110988073</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107001.1">
        <property type="nucleotide sequence ID" value="XM_022251309.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107002.1">
        <property type="nucleotide sequence ID" value="XM_022251310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPN0"/>
    <dbReference type="GeneID" id="110988073"/>
    <dbReference type="KEGG" id="aplc:110988073"/>
    <dbReference type="OMA" id="LMKDEWK"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46763">
        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 8"/>
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    </dbReference>
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        <property type="entry name" value="DYNEIN REGULATORY COMPLEX PROTEIN 8"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107001.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022107002.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18813" checksum="861598F0F7FC06D9" modified="2022-01-19" version="1">MAAPADEKESAESLLAETQKKIADAFDIFDHESNKTVDVREVGTIIRSLNCCPSEGELHDLLAEMEEEEPTGYIRFDRFLQTMTEVLMARKFKPSPEDQLQKAFEVLDTDKKGYLTVEELTKYMTEEAEPFTQEELEEMLSAAVDPDKGVILYKDYASLMAVDETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQA4</accession>
    <name>A0A8B7ZQA4_ACAPL</name>
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        <submittedName>
            <fullName evidence="11">NIPA-like protein isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
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            <taxon>Metazoa</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107242.1">
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        <property type="component" value="Unplaced"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
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        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="8">
        <location>
            <begin position="84"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="9">
        <location>
            <begin position="257"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107242.1"/>
        </source>
    </evidence>
    <sequence length="437" mass="48840" checksum="C7AE183718E90E4C" modified="2022-01-19" version="1">MIIFKMAEKRKLPSASSGAKRIKALFSSFIRKETNNETKAESSLESGDPEVKIDGTEGQVTGDTIDGAVSGSKPETPSRRSFRPLNIEDFFGRVETFTAFGWFAKPSDLSPLHCARHGWENINADCLKCVSCREILCGGLPVMWETDSYAQAYGKLKDSLKIAHSKICPWPDSPSPESFLHIPLGDVKSAVESFYSRLDTMHLLGVSLPSIDCSIIKEEEQFVIDEVEPALLKLIAEREDSAIIVSEEEKPIWLTVCLLAVFGWLKSHTEQTGCPVLVCQYCRRHAGLWNFISLKEAEAKPAIINEASSTDTERQESPTDRIKDIEKSAFNPATEHRSWCPWIQPSAFQPLRLQRTSNELTQSDDKPIAKLSWQQLLIILLKRTDPQTYGALAPVINKETTPPSQTWKAVRRILNIWQSKETAPPPNATTDPPKDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRJ9</accession>
    <name>A0A8B7ZRJ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein 64 homolog, isoforms 1 and 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107697.1">
        <property type="nucleotide sequence ID" value="XM_022252005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRJ9"/>
    <dbReference type="GeneID" id="110988480"/>
    <dbReference type="KEGG" id="aplc:110988480"/>
    <dbReference type="OrthoDB" id="10070404at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107697.1"/>
        </source>
    </evidence>
    <sequence length="915" mass="102433" checksum="787228D0C1C8A1F6" modified="2022-01-19" version="1">MKVLQNGRISCMISQVKMASQEVQLRCKLCQFTASSKQEIADHFMDVHAAVEIIGTSSPNPSGPTPETGSTCANLNNEAGDAADPSTSDALPSAGMEVGTADRALSKKKVGFRGNALRSTISHLVRAAEQASKEERSANSAKTPKSVRRHQQASAVKEISQTVHAVGRELRKHKMKRKFEDFVLLDNDQPQRKQPKVSPTKGTAGKPGPAGAKAGGDKQTASRKSRRTKQTQVVKGSKVKATELKKKMDDELQQWYEKWSQNRKSIMETCKNANCNSQLPPVEMKLHEQCHMKNYTGFKCPHCNHMHSQWRNMRCHIYNDHQEIAKPLLLCDWPGCSAPFTILWGLKRHVLRDHIQPKAIQENVSEQDESLVEVGEAEEQSRKDKASEESLPSEEADLVAKRAAIRKKLSKGMEEYVDAGTTEEEAVKKIRNRKKFHKIAWLPSCSVCEAKYISIENMDAHIALHTVEGSDSVKCAECGIIVDDCTKLRAHMKEKHRRLLKVYRCELCKYAGDRHYDYKKHLLTHEDTKPCMCEVCGKLMSTVYNLKVHILRVHATEEQKTVHCQHCDYRCADKIVLKDHMRFQHNLLWNGDPYKDVDTWRSYKCDKCDYVGRKEKSLKYHMRVHTEHRQFRCSMCCYASGTKNNLILHMRTHAGLKPVKCSECDYRGATNKVVNEHIMSKHRGIRPFKCPCGWSTAYSGNMWKHMQFHREKGDAYKDIAEARYGKPGPKKKKQVQHSEAPIIQQPQIITIVHEFQDAQDAGTLNSGSHQPSATVVPFQESTLAAKDVPASSAVAHVEDLPILGTHLLLNSLVQAATAVAPSGTKAGSDDDPATAGLQQAPEELQDHKENQAASYLCKLAHAVSTQSTGQEQESPKQMAEGKELPLGSGVQVTEVQVPTANAGSVEQTIQELVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZRP1</accession>
    <name>A0A8B7ZRP1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10">Mitogen-activated protein kinase kinase kinase 20-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">LOC110988642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108064.1">
        <property type="nucleotide sequence ID" value="XM_022252372.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108065.1">
        <property type="nucleotide sequence ID" value="XM_022252373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZRP1"/>
    <dbReference type="GeneID" id="110988642"/>
    <dbReference type="KEGG" id="aplc:110988642"/>
    <dbReference type="OrthoDB" id="10013149at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031349">
        <property type="term" value="P:positive regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902533">
        <property type="term" value="P:positive regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="7">
        <location>
            <begin position="411"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022108064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022108065.1"/>
        </source>
    </evidence>
    <sequence length="482" mass="54358" checksum="FF449376C46B65BA" modified="2022-01-19" version="1">MEGASYVNIDRKDISVGPVISSGACRNKVCRATWTLASSEKTVAVKVCNNFHEDEVLILAKLKHANVIEFFGVVKPASAIDSYMIVTEYAEQGSLYDVIRQHRDNWPEYRQNRWMRWAQDGAKALEYIHQKGYQHGDVKSPNYLVTHDDTLKICDFGISRKWDFTISTVTNRGSYPWMAPEVFGNVADDSKSERKPCKVTTKSDVFSYGVVIWEMISGKAPYPDKVGFHIYKAVVERNERLQIPCDFPEHQQISDLLSKCWQANYKERPSMQKILRDLADIENGQRKTVGTSDNVPDAVAGPQTTPGVQQQTDAMQHFMSQEEPKEKRQKRMEETEGTNAATGGIPTTTAAAAAQLQPLPQLPQTRMPTHRTQPNDSGGDKNSNENPTGTLDDRSLYGISRYIAPRDLLPLSLQLGLSSAEFSQVEADHPQDFVRQTFSILVMWRNNLPHDVNQKEAFCVALEKVGRKDLAMQLANRSFELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSL3</accession>
    <name>A0A8B7ZSL3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110988535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107845.1">
        <property type="nucleotide sequence ID" value="XM_022252153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSL3"/>
    <dbReference type="GeneID" id="110988535"/>
    <dbReference type="KEGG" id="aplc:110988535"/>
    <dbReference type="OMA" id="KQGHYNQ"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19339">
        <property type="entry name" value="Wnt_Wnt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013300">
        <property type="entry name" value="Wnt7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF112">
        <property type="entry name" value="PROTEIN WNT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01891">
        <property type="entry name" value="WNT7PROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022107845.1"/>
        </source>
    </evidence>
    <sequence length="349" mass="39387" checksum="4FB8AAB580DA64CD" modified="2022-01-19" version="1">MYHFLYLGLLRLLYAWLILGSSLGALSSVVALGANVICSKIPGLSPRQRSICQNRPDAIVAIAEGAHMGLCECRHQFRYRRWNCTSDGSGETLFGQPMPSGYREASFKHAINAAGTTHAITQACSRGNLTNCSCDRSKETGLTEEGWRWGGCSADIEYGLRFSRIFVDAGETVNDARSLMNLHNNEVGRQVVQDNMAIDCKCHGVSGSCTTRTCWTTLPPFRQVGNILKDKYERSVQVEPVRARRTRRPAFLKIKDAKNFKKPRRTDMVYLQRSPNYCDRDPRVGSLGTVGRQCNRTSLGTDSCDLMCCGRGYNTHQYTRIWQCNCKFHWCCYVRCNQCSEQTEEYTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTE3</accession>
    <name>A0A8B7ZTE3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Probable Xaa-Pro aminopeptidase 3 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110988653</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108080.1">
        <property type="nucleotide sequence ID" value="XM_022252388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTE3"/>
    <dbReference type="GeneID" id="110988653"/>
    <dbReference type="KEGG" id="aplc:110988653"/>
    <dbReference type="CTD" id="63929"/>
    <dbReference type="OrthoDB" id="4215474at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000002">
        <property type="entry name" value="Xaa-Pro aminopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="6">
        <location>
            <begin position="77"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022108080.1"/>
        </source>
    </evidence>
    <sequence length="518" mass="58427" checksum="B2BF4A066AE6A474" modified="2022-01-19" version="1">MARLICLGRTAKLLIAWNHPKNTKILNVIKSHGRLLCTCYGHLSQQDGIFLPKRYLGQPTPFTHKHLLKTNEITPEITRQEYMDRRTDLMSAIGRSFSSASGSEHVVVVLSADKKYMTDDIPYPFRQNTSFLYLTGFQEPDSALVLESILGRNLPEHKATLFVQQRDPERELWDGPRAGTEGALQFLGIHECQPIGDFSEKLHSLASSKSELVAWYDVFKPPHAALHKEVQETFVQQCRNRGHPVNILENVLQSQRVIKSPAEQNLMQTSASVAANAIKDVMEFSQPGINESILYAKLDYSCRIRGAEFLAYPPVIAGGNRANTLHYISNNQEILNNELVLMDAGCEYHGYASDITRTWPVNGRFTDPQAQLYQAILDVQKDCIEMCTVGGTLDQVYHFMLAELGKRLQEMRILPSGLAEWEICKMAKQYCPHHVGHYLGMDTHDTGRISRSSQLQHGMVVTIEPGLYIPELDTSAPAKYRGIGIRIEDDILITDKGPEILSAECPKEIEELEKLIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTJ5</accession>
    <name>A0A8B7ZTJ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110988825 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108397.1">
        <property type="nucleotide sequence ID" value="XM_022252705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTJ5"/>
    <dbReference type="GeneID" id="110988825"/>
    <dbReference type="KEGG" id="aplc:110988825"/>
    <dbReference type="OrthoDB" id="10407319at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108397.1"/>
        </source>
    </evidence>
    <sequence length="164" mass="18389" checksum="560437FD89916807" modified="2022-01-19" version="1">MTQTLSSRKRNRDLEDSELLPSPKRTDFNFNSSPLLNGHSDGNEEPVGSSRYSETDACFNGQPTPTHSRHCPVQQATPSMLLQHTNNHSLPLNHPPNSKNETYLDSSTCTALSNLHLIPGDHTEVPSCSHETLALENSIYRDINRVLREAHFSRLSRLNGAFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZU26</accession>
    <name>A0A8B7ZU26_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase CBL</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110989191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022109068.1">
        <property type="nucleotide sequence ID" value="XM_022253376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZU26"/>
    <dbReference type="GeneID" id="110989191"/>
    <dbReference type="KEGG" id="aplc:110989191"/>
    <dbReference type="OMA" id="PWAPADN"/>
    <dbReference type="OrthoDB" id="7237699at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16709">
        <property type="entry name" value="RING-HC_Cbl-b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09920">
        <property type="entry name" value="SH2_Cbl-b_TKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000022">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000015">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000007">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024162">
        <property type="entry name" value="Adaptor_Cbl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014741">
        <property type="entry name" value="Adaptor_Cbl_EF_hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003153">
        <property type="entry name" value="Adaptor_Cbl_N_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014742">
        <property type="entry name" value="Adaptor_Cbl_SH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039520">
        <property type="entry name" value="CBL-B_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024159">
        <property type="entry name" value="Cbl_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007">
        <property type="entry name" value="CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007:SF11">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02262">
        <property type="entry name" value="Cbl_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02761">
        <property type="entry name" value="Cbl_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02762">
        <property type="entry name" value="Cbl_N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47668">
        <property type="entry name" value="N-terminal domain of cbl (N-cbl)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51506">
        <property type="entry name" value="CBL_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cbl-PTB" evidence="9">
        <location>
            <begin position="22"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="359"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="754"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022109068.1"/>
        </source>
    </evidence>
    <sequence length="914" mass="100867" checksum="2C5066A2F764E1F8" modified="2022-01-19" version="1">MAQPGGRKPGFFSRVADLMAAPRPAVDRKTLEKTWKLMEKVMRLCQHNKMKLKNSPPYILDILPETYHQLRLIWSKYEGDPDKLHELNDNLYFRIFVDNIMKKARQTIQLFKVHKEKMYDENSTGRRELNRLSLIFSHNLAELKAIFPSGVFSGESFRITKQDAAKYWKKNFGTSTIVSWKSFSQSLYEVHSFQKGLEAYALKTTIDLTCNDYVSNFEFDVFTRLFQPWNTILRNWNCLAVNHRGYMSFMTYDEVKNRLQAFISKPGSYIFRLSCTRLGQWAIGYVTQDGSILQTIPQNKSLCEALIDGNREGFYLYPDGADDNPDLTSINTKPMEEHIHVSQDQYALYCEMGSTFQLCKICTENNKDIRLEPCGHLLCSSCLNAWQLRMNANKDSDGQGCPFCRCEIKGTEVIVIDPYQHQGSKDKTNGAEEKHDSEFDDDDDDGLEMPPTEPVYAAPQKGPKTEPPKKLGASNVPALPPRRPSPNVSPTSSPNMSPRSSNHDLSEAGRGASAGDGKASGFPTLPPRRYLDDRLERTEADGFATAETQKTGPKAFPSTEGIYDHPPPPQSAPRARITPPATTTVNDLILLSTPAPTGDDSRGGSPAPTPFPTGTAPGPAPGSPKGHMNLLYERLSNAHSPSSPGAAAAPTNPFLRSGSDTQPEHLTSLKAQPQAHRSAEELHALFSASDDPFATALDGGVFYENSIGYLNLPPPLNPALHHPSAPSPSSAVQSEQKHFGYENVPHLTQALTLGGRASPSEDYDIPPLRPHLSMNSQAPVTTQQPRMPVRETPEDYDIPPLPPMGTRPPLQQSSQPPPLPTQPRPMSSPAPSSDQALPLGQRQVPSPPTNGVLQPTKVAGAGAGDPTTVQGKMETLVREGYRMDDIRKALDISQNDLTMARKILRGFSNPATST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUQ9</accession>
    <name>A0A8B7ZUQ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="29 30">N-fatty-acyl-amino acid synthase/hydrolase PM20D1.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="29 30" type="primary">LOC110988230</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:134022"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:51313"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:51314"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:133992"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:51318"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51300"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:134020"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:51301"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:51302"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-L-phenylalanine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + L-phenylalanine</text>
            <dbReference type="Rhea" id="RHEA:64132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:77016"/>
            <dbReference type="ChEBI" id="CHEBI:149701"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:64133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycine</text>
            <dbReference type="Rhea" id="RHEA:64108"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:59002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:64109"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:64110"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:64116"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:149697"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:64117"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:64118"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-(9Z-octadecenoyl)-L-asparagine + H2O = L-asparagine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:149730"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:64137"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N-(9Z-octadecenoyl)-L-glutamine + H2O = L-glutamine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:51356"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:134033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:51357"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:51360"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:134035"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:51361"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:51362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N-(9Z-octadecenoyl)-L-lysine + H2O = L-lysine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64192"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:149731"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:64193"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-(9Z-octadecenoyl)-L-methionine + H2O = (9Z)-octadecenoate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:64144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:149732"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:64145"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N-(9Z-octadecenoyl)-L-serine + H2O = L-serine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:51352"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:134031"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:51353"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N-(9Z-octadecenoyl)-L-tryptophan + H2O = L-tryptophan + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64176"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:149733"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:64177"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-(9Z-octadecenoyl)-L-tyrosine + H2O = L-tyrosine + (9Z)-octadecenoate</text>
            <dbReference type="Rhea" id="RHEA:64184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:149734"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:64185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-hexadecanoyl-L-phenylalanine + H2O = hexadecanoate + L-phenylalanine</text>
            <dbReference type="Rhea" id="RHEA:64124"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:149699"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:64125"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-octadecanoyl-L-phenylalanine + H2O = octadecanoate + L-phenylalanine</text>
            <dbReference type="Rhea" id="RHEA:64128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:149700"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:64129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>an N-acyl-L-amino acid + H2O = an L-alpha-amino acid + a carboxylate</text>
            <dbReference type="Rhea" id="RHEA:15565"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="EC" id="3.5.1.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:15566"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:15567"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate</text>
            <dbReference type="Rhea" id="RHEA:54184"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="ChEBI" id="CHEBI:138093"/>
            <dbReference type="EC" id="3.5.1.114"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54185"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:54186"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107246.1">
        <property type="nucleotide sequence ID" value="XM_022251554.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022107247.1">
        <property type="nucleotide sequence ID" value="XM_022251555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUQ9"/>
    <dbReference type="GeneID" id="110988230"/>
    <dbReference type="KEGG" id="aplc:110988230"/>
    <dbReference type="CTD" id="148811"/>
    <dbReference type="OMA" id="DWTHHPF"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990845">
        <property type="term" value="P:adaptive thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.900:FF:000003">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="27">
        <location>
            <begin position="240"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022107246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_022107247.1"/>
        </source>
    </evidence>
    <sequence length="494" mass="55235" checksum="3A50351A3C84EED3" modified="2022-01-19" version="1">MLLSILSVATAGLSGLAAILVLRAITAKSKQPKPSGLSLDTTQFDGNRKIVTNLQEAIRIETVSRKPGDINYSEILKFHAFLQKVFPKVHSSPLVTREVIASYSLLYTVEGSNPSLKPYILAAHIDVVPVDGQDWDVPPFEGREQDGCIYGRGTIDDKHSLMGILEALESRLERQEKPVRSIYLCFGHDEEVTGLDGAANIGKTLQERGVQAEFLLDEGYTILQDVIKHVHRPVGLIGVSEKGHATLRLSVDTAETGHSSMPPKETNVGILAKAVSKLETTPFPSMFGSGVEYDNFVYLASEVEYPIKLVFANLWLFKKIVERIMQQKESTRAILHTSTAITVFRGGVKVNVLPPSASAIVNHRIHPSQTIQQVLERDRRLINDDRIKMEILQSREATITSPYDEQCFAYQSIGQSIQQVFPDAIVAPAILLANTDTVHYTSITDKLYRFCPTFNLPEDVPRFHGVNERIRISNYEQVVKFYYILMHHADREQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZW50</accession>
    <name>A0A8B7ZW50_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110989586</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110989586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109778.1">
        <property type="nucleotide sequence ID" value="XM_022254086.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989586"/>
    <dbReference type="KEGG" id="aplc:110989586"/>
    <dbReference type="OMA" id="FPRAICT"/>
    <dbReference type="OrthoDB" id="10022583at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35555">
        <property type="entry name" value="ENDONUCLEASE-REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35555:SF3">
        <property type="entry name" value="ENDONUCLEASE-REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022109778.1"/>
        </source>
    </evidence>
    <sequence length="488" mass="55222" checksum="B7C8861ADAF8D680" modified="2022-01-19" version="1">MFHPSNSSATLCQSPPMPKWLWLCISKSLGIKTHPQDKPVLATVLFIFTLVCILTYFITCTWYVVYDIEATSTKFDVLNGSVIVIMAAGFCCITIYANLLAFKLFTNPVFRQSLRLHSKTVLKVNVSILLAVLSLLFIGIYAYISYCSEFGAQPCEEVKLNPLICYIRYPSQTTLSIVSFLWNLLVAVVCLSVCRTHTISIRHFLLELDDDAVIYEMQNRHTVVSITTTDGVAIPVNASEESRDANSTVDIKENLDVRQIEAAWDRSEFERRQHRVSTCLTDGHIVAADEEEGLEQELPDTAADRRPRMXQDGGRRQRESVTSAFTHTPAVKPLTNAEILDRYWRLQCRLNTTSAILQRWITSWIILILLWSLYYLMYWIDHDASIWDMIVFFIPLALLPLLCSGPIEVNGEGERVAKMICPIQERMPVIMFIRQAPLAFTIYGFVLNYSTIITAILAIAVAFGTKIILGNFTVTRVPATTALPSWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXP5</accession>
    <name>A0A8B7ZXP5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">CMP-sialic acid transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12 13" type="primary">LOC110989926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110318.1">
        <property type="nucleotide sequence ID" value="XM_022254626.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110320.1">
        <property type="nucleotide sequence ID" value="XM_022254628.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110321.1">
        <property type="nucleotide sequence ID" value="XM_022254629.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110322.1">
        <property type="nucleotide sequence ID" value="XM_022254630.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110323.1">
        <property type="nucleotide sequence ID" value="XM_022254631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXP5"/>
    <dbReference type="GeneID" id="110989926"/>
    <dbReference type="KEGG" id="aplc:110989926"/>
    <dbReference type="OMA" id="CLYCREN"/>
    <dbReference type="OrthoDB" id="419167at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022110318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022110320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022110321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022110322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022110323.1"/>
        </source>
    </evidence>
    <sequence length="330" mass="37048" checksum="13886790B03D585F" modified="2022-01-19" version="1">MMLGLVDCGSWLVFLAYITLFVNNNLLIVLTKDEQDGYSYSTVLVTLLIELFKLMVAVIFYCLKYSFAKLITDLQSNNSGFAFYLLPSALYSVFNNLAFLNLAYFDPTTYAVLLQFSIVVTGVLYQYMFKRDLTWLQWISLLVLTSGCILTHFKESKEVLFKLRDVFILLQVLCSSFASVYNEYLLKSYSSQVDFWLQSVFMYTDTSLCSVALMIAMGRLSPAMLTTSSMRSMFQPMVILIVTNNVTAGLVTGVFLHKLNSVLKKFAVAIEMIIIAVLSKFLLGTAVEISTAISVLLVSLSIILYSLNPLGSEREKVVRPDLKCSNGVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZZB6</accession>
    <name>A0A8B7ZZB6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110990205</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110769.1">
        <property type="nucleotide sequence ID" value="XM_022255077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZZB6"/>
    <dbReference type="GeneID" id="110990205"/>
    <dbReference type="KEGG" id="aplc:110990205"/>
    <dbReference type="OMA" id="HARFNGC"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022110769.1"/>
        </source>
    </evidence>
    <sequence length="315" mass="33477" checksum="DD2AC5BAEB289F42" modified="2022-01-19" version="1">MGRPGFSGFSPRGGGFNSRGGGGRGGGFRGGGGGERGGFRGGRGRGGGRGGSRGGFTPRGRGGPRGGRGGRGGGMRGGKKVFVEPHRLEGVFIARGKEDALVTRNLVPGETVYGEKKIAAEEGEVKTEYRAWNPFRSKLAAAILGGIDKIHMKPGSKVLYLGAASGTTVSHVSDIVGPEGLVYAVEFSHRSGRDLINVAKKRTNIIPIIEDARHPHKYRMLVGMVDCIFADVAQPDQARIVAINAHSFLKNEGNFVISIKANCIDSTAQPEVVFAGEVKKLQAEKLKPQEQLTLEPYERDHAVVVGVYRPPPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0B5</accession>
    <name>A0A8B8A0B5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="4">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">LOC110990223</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="4"/>
    <dbReference type="RefSeq" id="XP_022110796.1">
        <property type="nucleotide sequence ID" value="XM_022255104.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022110797.1">
        <property type="nucleotide sequence ID" value="XM_022255105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A0B5"/>
    <dbReference type="GeneID" id="110990223"/>
    <dbReference type="KEGG" id="aplc:110990223"/>
    <dbReference type="OMA" id="THCIRTS"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF22">
        <property type="entry name" value="VERY LONG-CHAIN ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="8">
        <location>
            <begin position="69"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="9">
        <location>
            <begin position="513"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022110796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022110797.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="71110" checksum="0A52D16882BC3B2D" modified="2022-01-19" version="1">MPDPRSNYQRAARVAAATALGLPTAGLAYLRLKYGPTLADDVVKIYKGYKVMKRVQHAQENNFFIVDFFELHVKETPDRPFLLYGDDTYTYGDMDGEANKLARFVMRHGALSCKDSAAILMLNEPGFIVSWLAFSKLGVQTAFLNYNLKGRALLHCMKACKIKAIICGKDTWLLKELETIMPEIQDLGIKVWVLGKVTERPLPSGMTLVNTWNERSDPIPKSTRAGISIRDPSVYIFTSGTTGFPKAAKVSHYRSCAASFIMSSMGHLEGSDIFYVTLPLYHIFGFSMGLLTSIVTGCTVALSTFSPKIFWDEVRKYQANVILYIGEICRYLLAQPPCPNDGELKIKCAIGLGLRPDVWEDFQKRFNVGQIYEQYGATESPFMIVNTEDKVGSVGRFGGLMKAVLNIIEIVKCDIETAEPIRDANGKCIIAEPGETGLFVVKVDQRIHFDGYMADKKTNEKKLVRNVKKVGDVYYNSGDLMMVDKEGYLYFKDRLGDTFRWKGENVSTTEVAEIMGIFPAIMESNVYGVVVPGKEGKAGMAAVRLKKDVEFDPKSLYDHVTKALPLYACPKFLRITEEILTTTTFKHQKSNLAKEGFDVNIISDPLYFLDVEKKTYVPLDKDVMRRIVIGQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A134</accession>
    <name>A0A8B8A134_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110989474</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:36684"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022109556.1">
        <property type="nucleotide sequence ID" value="XM_022253864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A134"/>
    <dbReference type="GeneID" id="110989474"/>
    <dbReference type="KEGG" id="aplc:110989474"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349">
        <property type="entry name" value="ANKYRIN REPEAT AND LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12349:SF2">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="113"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022109556.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="59921" checksum="B2EDC1B6819C0FD1" modified="2022-01-19" version="1">MPILCQRTRMSCCEKKFNFKPSTKYVPVTVAYALLICTTTLFFVFPLPCLVNTIHPAVAVYSAVLFSVVFLNFVLATFVDPGVFPKTKGDEDGDEDFRAPLYKTAEIQGIQVRMKWCATCRFYRPPRSSHCSVCNHCIEKFDHHCPWVNNCIGKRNYRFFFIFLLSLTAHMVSVFTLTLTFVLNEKEKLGYAKPIISLVILCITALAAFPIFILVIFHISLVCRGRTTNEQVTGKFRSGHNPFDRGFIENCVTVFCTPTLPRYIGYRGFSLSLASMYLPSSHGENSVAQSHVQLDIDEAVSPNINSSYKVTTQPFEFKPSPLTHRVHYSVDMNSLSNESQGDDCEADPPPHPSVKNSKVTLFRDLPCTDSAIGSQIEKSLKDPKSEITCSRDNSKLIASQSKRGEPRSWNYTEDKSADVGKNGNLVPSSKQLGIFETSESQLHVNKHTISNGTYYPGSNDIPRKRRPISFVTALQMSEELDVKKRQQLGPVCYDGLERKVGTQGNSIDAKHLSETNSDLHCKELSSCTKYEISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A3J0</accession>
    <name>A0A8B8A3J0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">LOC110990707</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022111495.1">
        <property type="nucleotide sequence ID" value="XM_022255803.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022111500.1">
        <property type="nucleotide sequence ID" value="XM_022255808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A3J0"/>
    <dbReference type="GeneID" id="110990707"/>
    <dbReference type="KEGG" id="aplc:110990707"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006699">
        <property type="term" value="P:bile acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000011">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="17">
        <location>
            <begin position="73"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="282"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="509"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="516"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022111495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022111500.1"/>
        </source>
    </evidence>
    <sequence length="932" mass="105616" checksum="3315D3A55B3411C0" modified="2022-01-19" version="1">MEDADTKERRQRLQLQKKHSQTEEMEPIAEAVVMTGSLASAIGTGAPDEADKKSPKLLPLDLEKVGQTVEKEPGKIEGYLLKRRKRPMKGWHKRYFVLEKGMLTYGKNCGELMKGKIHGTIDVLSAVISTEKEEDSKARRIDIDTEEFLYHVKATSHDEFLAWHNHLLLHQAYRKQVQLAEEALLSNGPAVVGGPPHPAAATSPTSEITLKAMTLERRRLSLRKQMSKYRLPGPLTTQSSGNWKMEIAELDKCSKELTEAENSVVTLSNIIQDLLNQELPYPYGPQEPEVDDIAGQKRSKGKLSLRKGKTKKSSSDPSVGDVRRSSSSSTIIPGNSTGNDTMHSTTSSKQLVEESNPRDDFMDMANQVHRILKGVLHLLSVQHDRLRFVIESQNSVGGAASQSRQIAILQEALAKARSQNEDMRGRLSRIQAESNIQDLSPPIKSDTELLGGGTLETLLTKLSRNRSVDLEDGMVTAKSYGLSPQLSDDREMSRSESLLEFYDALEYPASSTASSSEDEEEIESSSLASEEEAEMREEDFLDLEEEDSEGLGKSQTGRRTQLPAPQPDTSGLSLWNILKKNIGKDLSKISMPVALNEPLSMLQVLAEELEYSELLDKAAETDDPCKRMVYVASFAVSSYASTYFRAGTKPFNPLLGETYECVREDKGFRFVAEQVSHHPPISACHCESKNFIYTQEVRIKTKFWGKSMEIIPAGTINIRIPRYNDNYKYNKVTSCVHNILSGERWLDHYGECLITNGRIICKLTFTKASYWSNRRHEVHGLITDDGQVVHELFGKWNEGIYCGRSASAKCIWRTGSMPENHSMYYGFTRFAIELNELDPYTRHLLPATDSRLRPDQRKLEDGDVISAEREKQRLESLQRERRKWREEQNMDYEPRFFRFTKENGKEVCIFKNDYWDLRRDPGFKNLSTTELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XG52</accession>
    <name>A0A8B7XG52_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine triad nucleotide-binding protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110973061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079216.1">
        <property type="nucleotide sequence ID" value="XM_022223524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XG52"/>
    <dbReference type="GeneID" id="110973061"/>
    <dbReference type="KEGG" id="aplc:110973061"/>
    <dbReference type="OMA" id="FRIVMND"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000005">
        <property type="entry name" value="Histidine triad nucleotide-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="70"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="162"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022079216.1"/>
        </source>
    </evidence>
    <sequence length="178" mass="20046" checksum="2EA5A3B7577FD6B7" modified="2022-01-19" version="1">MALRQIFARTWTHGKFPGFRSVYDERLTDVARARGALFCQLRSLTSDESSSEEKLAADAARRHNRDKPNVFQKIISGDIQADTIYEDEQCMAFRDVNPVAPTHIIVIPRKPIPCLSESTDSDAPLLGHLMTVARKVAALEELKDGFRIVMNDGRHGSQSIYHLHVHVIGGRQMRWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHR0</accession>
    <name>A0A8B7XHR0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110973653</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110973653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022080333.1">
        <property type="nucleotide sequence ID" value="XM_022224641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHR0"/>
    <dbReference type="GeneID" id="110973653"/>
    <dbReference type="KEGG" id="aplc:110973653"/>
    <dbReference type="OMA" id="WRVCYRP"/>
    <dbReference type="OrthoDB" id="10330884at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032281">
        <property type="term" value="C:AMPA glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016247">
        <property type="term" value="F:channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005245">
        <property type="term" value="F:voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099590">
        <property type="term" value="P:neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098943">
        <property type="term" value="P:neurotransmitter receptor transport, postsynaptic endosome to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098970">
        <property type="term" value="P:postsynaptic neurotransmitter receptor diffusion trapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019226">
        <property type="term" value="P:transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051072">
        <property type="entry name" value="CACNG_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107:SF0">
        <property type="entry name" value="STARGAZIN (MAMMALIAN CALCIUM CHANNEL) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12107">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13903">
        <property type="entry name" value="Claudin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022080333.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="24078" checksum="FF7B5647FAF3CE94" modified="2022-01-19" version="1">MPWHPYTKILLLLCFIGLIAFLTTAMGLGSDYWLIYRLSANATADTNSTNVRLARAGVWRVCYRPEALPDDGKPCHNINYLSEVENRDPLYQYIYPVYGKDLLLGFLALVCIGVALIFVAEVLAMICLKKRSKAMYIGTAVIFILAGIVGSAGLIIFSLRGAQLLYDWPNSQLGESPYDMISFGWSFAITWLGAALALCNSTGYMWLARRHLDAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHR6</accession>
    <name>A0A8B7XHR6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fatty acid hydroxylase domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110973275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022079657.1">
        <property type="nucleotide sequence ID" value="XM_022223965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHR6"/>
    <dbReference type="GeneID" id="110973275"/>
    <dbReference type="KEGG" id="aplc:110973275"/>
    <dbReference type="OMA" id="QYAHPIE"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="197"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022079657.1"/>
        </source>
    </evidence>
    <sequence length="362" mass="41570" checksum="06B933DC918E06C5" modified="2022-01-19" version="1">MECATVREESCCAGPSRAPAKIDTKPQEAKTPQAELMSQWADTIKKVIFIVGGAVIVFAAACNSLTWHLQSFWGASGDFWNRQWMKVYHLFGGNLFMLEVVGTQMVTFVFYWLFNAFFLFVDITGKPAFILKYKIQDDQNTPVPWPKLRKALQTVLFNQFFVNIPFAVFLYVMMQLRGCNISADLPTFKWVLVELGVFLIFEEIGFYYFHRLLHHPRMYKHFHKKHHEWTAPIGVTAIYAHPLEHVLANMLPPVIGPLLMGSHVAVLWVWFLIVEASAIVAHCGYHLPLLPSPEAHDFHHLKFTNCYGTLGILDRLHGTDNLFRESKNYPRHILLLGLVPLSQTFPDDPKQKRKDLEGKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJK0</accession>
    <name>A0A8B7XJK0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973647</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080317.1">
        <property type="nucleotide sequence ID" value="XM_022224625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJK0"/>
    <dbReference type="GeneID" id="110973647"/>
    <dbReference type="KEGG" id="aplc:110973647"/>
    <dbReference type="OMA" id="QVSCRRK"/>
    <dbReference type="OrthoDB" id="10354971at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080317.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="28432" checksum="628E910D2FCE052F" modified="2022-01-19" version="1">MQDHSRVRSLSLDDINVGMSSSSLSAATSTAASCRKGKSSSVDDDRQDNDVTEEGEGRDRDTLGELESPAIENLQDRLLVTPIRWQMRSEAAVAPTGLYRRDSAPATLLQKEDSISRRCSNPALLETIEEGQVSCRRKSTPAVMTQGLAQQRGRGGGAHLSPRRALLKAVSAPGSAPARRRSMPEISTHQRSPVMLETFYPPPRRNSLMSCSLAEVAARFELLNTNSRVPEESELLEKSRAGYDRSNGSGVSSSHSLPPITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJK3</accession>
    <name>A0A8B7XJK3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F-box/LRR-repeat protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110973997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080969.1">
        <property type="nucleotide sequence ID" value="XM_022225277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJK3"/>
    <dbReference type="GeneID" id="110973997"/>
    <dbReference type="KEGG" id="aplc:110973997"/>
    <dbReference type="OMA" id="GEMFCGH"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22118">
        <property type="entry name" value="F-box_FBXL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12109">
        <property type="entry name" value="Hr_FBXL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045808">
        <property type="entry name" value="Hr_FBXL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="203"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022080969.1"/>
        </source>
    </evidence>
    <sequence length="663" mass="74539" checksum="E3B4DFD7A6B8DCEC" modified="2022-01-19" version="1">MAPAPKEVDVFSGPHSRMKELVRIYSDKLTATDFSNYAELRGLLWSLRATFREFKTHEHIENECIMQKLRHRLDYLKIENQAVYKIHSDNRLSEMQGLLEEGCKKTEHCHSPSEMITIGSKIRDALEVFTKDFLPHMQEEEECFQPLLMKYFTYEELKRIRYDVIERHTLHTKYRSENDKELAPEESYEKVDDVKDDISNTSQDKTAGLPSEVLVHIFSYLSPKDLCRCAQVNSQWNQLAMDGMLWKSLHPVRWAQGDWRFVIDDFHQDIEDLGSDDGEGNYITVDEDADFNESESSADSDEKDSHEVSQSALRIRREAKMLDGIAKHLIPVVGHGVETLMLSQSKGLNNAMVYRLLSNAPNLKQLDLSLTKISDIAFKRFGKNGSGRRLKHLNLSGCTSITDATLKRLSLAISPPLGKEEPNGDTSSHQLSCSLGACGKYCSEVISIDELSTDKNGRPKSQCAEKTVSSDSYEVHLNHSSQGTRLGARLGSTGQHSKCKEMSEAFLGKLNRENNICQSFQADDSPYRTKDCCGNSKGSAVTHRTCCTNISTMDRSDGFTDRQLANHTSQLEFLSLAGCYRITDDGLRYLAGNGGQPRLRYLDLSGCLSVTSTGLNQLAAACTSLDHEEFFYCDNILEGPYADTASGCQNLQCRHLVCCRSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJQ4</accession>
    <name>A0A8B7XJQ4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Disease resistance protein RGA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110974031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase C14A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081028.1">
        <property type="nucleotide sequence ID" value="XM_022225336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJQ4"/>
    <dbReference type="GeneID" id="110974031"/>
    <dbReference type="KEGG" id="aplc:110974031"/>
    <dbReference type="OMA" id="YRMRTRP"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002138">
        <property type="entry name" value="Pept_C14_p10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015917">
        <property type="entry name" value="Pept_C14A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF36">
        <property type="entry name" value="CASPASE FAMILY P20 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00376">
        <property type="entry name" value="IL1BCENZYME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00115">
        <property type="entry name" value="CASc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50207">
        <property type="entry name" value="CASPASE_P10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Caspase family p20" evidence="7">
        <location>
            <begin position="278"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p10" evidence="6">
        <location>
            <begin position="468"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022081028.1"/>
        </source>
    </evidence>
    <sequence length="555" mass="62472" checksum="E1C2ABCDEAC62B5E" modified="2022-01-19" version="1">MAGVERQEWSLQALGISPYRGNAYDLRIDLNYRNLQHLPPDLFSLGELQWLNLNVNKLRDLPADMTRLSHLKWLYLENNAFQSCPEVVCRLTELVRLYFSCNLLSSLPNAIGRLTHLRWIDLSDNRFAEFPTVLCCGSLAENLERLFLDNNQITSLPGQIANMKSLKLLWLNDNRLEWLPHALCELTGLEELQVRNNPLRCLPVFLAGKLSNLKVFEWQGCPLIQQLTEACQKGVSGLGDHQDQVNKRAEKRGMVHFRAEAGLDGGRERPCYRMRTRPRGVAIVIDNFCTLEVGESLNGRTSSQSSESDGRENAKGEDSTDRLRSVLIKLGFNVRVMRGLMSLDIISALRFLSLEDHSYFDCVIVCILSRGARGGKIIGPDGIAVDVQQLTDIFTRDNCPTLADKPKLFFLQVLESDAKGKQLSPRESDAGKELPTATLIPDDYDFLLTFALIPKAAKSDSLDSVYHFYVGVLFDMLEKFARKLNLLDVMTTVHGEVKKRRLLSENSPEERVQISPEIQTTLRYNLYLSMGSPAAGQGSRISKSVPSSRAATLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKB1</accession>
    <name>A0A8B7XKB1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">LOW QUALITY PROTEIN: nidogen-1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110974148</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081243.1">
        <property type="nucleotide sequence ID" value="XM_022225551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110974148"/>
    <dbReference type="KEGG" id="aplc:110974148"/>
    <dbReference type="OMA" id="DECQRGD"/>
    <dbReference type="OrthoDB" id="6375837at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000241">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.155.10">
        <property type="entry name" value="Green fluorescent protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006605">
        <property type="entry name" value="G2_nidogen/fibulin_G2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009017">
        <property type="entry name" value="GFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051830">
        <property type="entry name" value="NOTCH_homolog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24033:SF151">
        <property type="entry name" value="NOTCH 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07474">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SMART" id="SM00682">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54511">
        <property type="entry name" value="GFP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50993">
        <property type="entry name" value="NIDOGEN_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034862183" evidence="15">
        <location>
            <begin position="25"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="18">
        <location>
            <begin position="105"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Nidogen G2 beta-barrel" evidence="17">
        <location>
            <begin position="434"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="654"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="694"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="732"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="771"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="812"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="853"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="894"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="934"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="977"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1019"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1061"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1101"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1142"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1183"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1225"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1262"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1354"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1397"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="13">
        <location>
            <begin position="1440"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="277"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="349"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="943"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022081243.1"/>
        </source>
    </evidence>
    <sequence length="1614" mass="172635" checksum="EF7D23DC1DB26E96" modified="2022-01-19" version="1">MGRFCTSPILLWTAILSVILSATGLTRDNFYPFGVQYGDGQLAAGDAVQGTLRLRIPLQFLNVEHDTVYVNTDGLVTFAPVPVEGQAPYTFGVSLKNSQVETIAPFGADYNTSEGGTVFYREAFRTEVLNRASRDVSQFFGRTGFQARSLTLATWDSLRFKDEGKTVTFQLVIPSDGDQTFVFFIYDDTNRAATNDYRVVGFSNGEGSHLTIGGHVSSFTNVGKSGMWAWQVGGANLGTRGFAKPIIDSQGSVINTGASGSASGGVVSGGATGGGGSSTFTLQGGGSTGGSAGGSDGQGAGGSTDGGGGSSFTIVVGDGTGKATSVTRGSSSSSSATVVTVGGGSVDVGAGGEATGGQVGGGGADGSQPSTGGGAGAGRFDVDFNVGEGLSPDSGAVCDTCHPQATCQKFSDGYCCVCPPTLFGNGQACLDPQGRQRLNGLVSGTVNGQSFSNANLHSFIILSEARTYTAVSPLPPEISYSLQTITPMAEIMGWLFALPSGKGLNGFMLTGGKFRQTLNITFSTGEQMLITQEFQGVDEDGYIRVIANWNGNVPEILPSDYIFVDDHKEEYSRHRIGLIHTFAKRTMQVNDDTISFTMDQTIEYDECVADEEDTEYILNFMRVSLTETYLTYEDGEKILRFSMIGKVTPASEQIDDRCLNNNCDRNAQCLPVGESGYRCKCNPGYEGDGQRCTLSDPCAQNTCDINGYCIPQLDRYTCACNAGYQGDGFTCRVDRCASNRCDPNARCVETTTGYECYCNSGFTGDGFRCQVRSPCDNNACDVNAYCVPAQTGYQCYCNEGYTGNGFNCEAEVRNPCDNNACDVNAYCVPTQTGYQCYCNEGYTGDGYNCQERIVNPCDNNACDVNARCLPSQSGTYQCLCNQGFVGNGFSCQEDQIDHNNECDANARCVTAAFGYQCFCNPGFRGDGYRCQANVTDPCANHTCHKNARCGPSSEEGTYECFCIEGYTGDGFTCEVDPTNPCANNTCDSNARCVASSPDAYECLCNEGYTGDGFTCEADRTDPCADNTCDRNAQCVASSQDTYECSCNEGYTGDGFTCEAIQVDRCSNNACDANAQCFPSETGYSCYCNEGFSGDGFVCQEVVDPCANNNCDANAQCVPSQGGYQCYCNQGFTGDGFTCEAIVDYRCRNNRCSVNARCFPTRTSYRCYCNAGYIGNGFTCRAVAVDPCSNNRCDFNAECSPAPGGGYTCECNQGWEGDGFTCRNILVNLCSACDVSAQCIPEGRGFRCVCNSGFEGNGLTCEDVDECSQSGTPCHRFATCYNVRGSFSCYCQPGYEGDGFSCQEIVQPPLDEGALMYARGMAVMRVPLNPNQPGSKVIFRSGQTIVGLGYDCSEEYIYWTDVSGRTISRAKADGSSIQVLINRGLSSPEGLAVDWLSRNMYWTDSGYDRIEVANLDGSNRRVLLNTNMVNPRAIAADPIGGFLYWTDWNRDGPKIERSNMDGSERTVLVDTNLGLPNGLSLDYTTSQICWVDAGTKRIECMNMNGDPLTRFTVFPNSNYPFSIASYGFKLYWSDWETKSIQSISKTGGAESTQLKLPRGGNGRIYSVVAVTSCPSASNACTTNNGGCSSLCLPLPGGLRKCACPTNLEGNEVPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMQ7</accession>
    <name>A0A8B7XMQ7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 174-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110974621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082104.1">
        <property type="nucleotide sequence ID" value="XM_022226412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMQ7"/>
    <dbReference type="GeneID" id="110974621"/>
    <dbReference type="KEGG" id="aplc:110974621"/>
    <dbReference type="CTD" id="51244"/>
    <dbReference type="OrthoDB" id="333551at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025066">
        <property type="entry name" value="CCDC174-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057464">
        <property type="entry name" value="CCDC174_GRSR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15885:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25449">
        <property type="entry name" value="CCDC174_GRSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13300">
        <property type="entry name" value="DUF4078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCDC174 alpha/beta GRSR" evidence="3">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022082104.1"/>
        </source>
    </evidence>
    <sequence length="473" mass="55105" checksum="764C9FE963C5C712" modified="2022-01-19" version="1">MNAKKKIEVNSSSLVGLKAELFRKQEALRKEKLQQGSTTIKSKPVPKKPSIWSKKNAGVQSRAEKDKSLTVEEENQLDKSRAALEAKTRLYEQMSQRSVLSADDEVSDRFLVDFEKKAIDELHEEKIYQQEKSEETEYEMGATDVPGPVDPEDEWVDYVDTLGRSRRCMKKDLPELINMDKRLNPQAFKDAEEKTTSEEPLPDLLSSDMYREMMRKKWEEEEEEMRRRGPGSVHYQNVRFDEVREMGVGYFDFSKDESERQKQMEMLKHLRDETLDQRSKSEQLKAKRKAALKARLEKVKQRKRLKGELVEDEEEQKDEEREEREEGEEVQQEEDVRQIAERLKAAPIRPWDIGKEESQWERVKRQVRAERPQEFAPPSCYYDGTAPAAKANPNTLRNNPQSKRLQEFAPPTDYGKRMYKDGGVHSWDWNCLGGEATTSGRMPRKDATNKSEHGTVDGKSIAQALSFFRQNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNJ1</accession>
    <name>A0A8B7XNJ1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Metalloendopeptidase</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110974351</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="RefSeq" id="XP_022081621.1">
        <property type="nucleotide sequence ID" value="XM_022225929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNJ1"/>
    <dbReference type="GeneID" id="110974351"/>
    <dbReference type="KEGG" id="aplc:110974351"/>
    <dbReference type="OMA" id="KCTSCLW"/>
    <dbReference type="OrthoDB" id="291007at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF780">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034274747" description="Metalloendopeptidase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="12">
        <location>
            <begin position="101"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="11">
        <location>
            <begin position="341"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022081621.1"/>
        </source>
    </evidence>
    <sequence length="457" mass="51677" checksum="0C1FF6A7118CD4E2" modified="2022-01-19" version="1">MKPMLLVMLAGFVVVVANDRMRRNEFAATSSVQGVLEGTYSESVVESQAREDTRAARMEAAPSPNSVEGDMIMTLEQEEEYMVVQEATAENKTRIRRSGATAFKGWPNGTLVYTYAADVSSHTKLLFEKAIKKYKEKTGIQFVEAHDGSYVGTIQPLTVRQRGAGCYATLGCVGVNCGGFINLQKYACEVIGVMLHEIGHALGRFHEHTRSDRDNHIFVIRSNIRPGFEKNFEKRQWPIVAPYDSHSVMHYAALAYSRDGVSETIFPYNARDRLKMGRQSELTRLDAYSINAAYNLFECSSPENVWKRCRRGGVPNKHCTCDCLPTFSGPYCETFEKPTDCSQIHTRRSGTITSPGFPRRYPNNAHCTYVIECSEKSLVELRFKNFRLEAGNCWYDTLSIFMGVLESETYPDVYCGNFLQGQLLVSFDNVVIMDFKSDSGIRFPGFEVKYRCVPTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNL3</accession>
    <name>A0A8B7XNL3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110974820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082404.1">
        <property type="nucleotide sequence ID" value="XM_022226712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNL3"/>
    <dbReference type="GeneID" id="110974820"/>
    <dbReference type="KEGG" id="aplc:110974820"/>
    <dbReference type="CTD" id="65005"/>
    <dbReference type="OMA" id="KWDIVSV"/>
    <dbReference type="OrthoDB" id="5555409at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="entry name" value="Ribosomal protein L9, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_bL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_bL9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_bL9_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054302">
        <property type="entry name" value="Ribosomal_bL9m_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22078">
        <property type="entry name" value="Ribosomal_bL9m_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Ribosomal protein L9" evidence="9">
        <location>
            <begin position="76"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL9m C-terminal" evidence="10">
        <location>
            <begin position="135"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022082404.1"/>
        </source>
    </evidence>
    <sequence length="241" mass="27599" checksum="2E90940AF57426DB" modified="2022-01-19" version="1">MALVTFASGCQLLRSLCRTAPITYMGWQQQRNAVKLRRRYPPPIPKLRGKPHRTKTSHYVYVFERDTMHDPKPKLPVILTEDVPRIGSRGDIVAVERSIARNKLLDKNLAVYASPENIKELKLERKEQEKEGTRKVMTPTALKTIAYLKKNKLTVRVRPFPRWDVLPKEAVLHAFDKNLGVVVAEHALELPEQPITDYGTYTVNVTVNQVETIPVEMDVLHYINKGKMKRRRQAAAASPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNX2</accession>
    <name>A0A8B7XNX2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110974890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110974890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022082513.1">
        <property type="nucleotide sequence ID" value="XM_022226821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNX2"/>
    <dbReference type="GeneID" id="110974890"/>
    <dbReference type="KEGG" id="aplc:110974890"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022082513.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="23719" checksum="3CC0ABA81EC38A25" modified="2022-01-19" version="1">MADESHGISSTVEDSLQSPPAGRESCLPRHRAPREESSVSVGEISVTGNNNPVLCGSDGNTLNFQKSADSDPKVLSTSTTSADETSGPLVLSKKSTSSQQREISTGEETIEDTLPPTPPYTRSSTRRVESLKIAGHENFTFVNCSVNIMNSSADSGIGDSFSSVDTSVGSDSRTSLTNHEVTGGKKETIDEGVIFLIDCYDPMFQQSKDGEDSPFQLTIKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSJ9</accession>
    <name>A0A8B7XSJ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110975567 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083839.1">
        <property type="nucleotide sequence ID" value="XM_022228147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSJ9"/>
    <dbReference type="GeneID" id="110975567"/>
    <dbReference type="KEGG" id="aplc:110975567"/>
    <dbReference type="OMA" id="WNTWISK"/>
    <dbReference type="OrthoDB" id="10173501at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083839.1"/>
        </source>
    </evidence>
    <sequence length="281" mass="30497" checksum="11BFF0842F253D94" modified="2022-01-19" version="1">MWLTPVPCIPTDSWNTWISKVAAFLNFGKKRQTTMRPYLPLIAIAICILGMVLSVQAGSGSRPAVYKNWPECTRDTEFVLVVKKSEREAGVRYHERHVTRKKGRTVKYYECMPCTRCAPGVHEEKPCSVHADTACSATECTVSGCILDANLHACRLPGDPNDFSDMSAMMDPCDPTKIKSTTTVEPSSRSPRPGVKQLVKKDSNTSLSKGDQRDAPPDERAESPAPLMDGPTVGKIGIILAVSIVCVVLVTAIAVTAVVYASKRRNGCSCNSPRGRSGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSS5</accession>
    <name>A0A8B7XSS5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Steroid 17-alpha-hydroxylase/17,20 lyase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110975111</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082986.1">
        <property type="nucleotide sequence ID" value="XM_022227294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSS5"/>
    <dbReference type="GeneID" id="110975111"/>
    <dbReference type="KEGG" id="aplc:110975111"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF20">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE_17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022082986.1"/>
        </source>
    </evidence>
    <sequence length="509" mass="57806" checksum="4A569C9ECB0D13AA" modified="2022-01-19" version="1">MAAFDVVGDVYLNVTTLLVAIGTLALYALYRSTKRPAGFPPGPTALPLVGNISLFLTKKAPQKVFQDLSKKYGSVYSLTLINENAIVLSSIDIVKEALLTKGVEFAGRPWIYSSDLFTEGFKNIASPNYGPQWRYQRKLGHTAVRHFAQKEQLEKLVFDTIPQISKYLDDLGDKPFAPKWIMGQIVFTVIANLCFGKQYQFNEPELMKWIDAYTNVIQCLIDGLPADYIPLFRYIPTPKETKFKKFLKIFHDKFYHEFNKHRHSFDPECINDFLDSLLRTQKENIEAGEEGADRLTDTHLVQTVVDTVVAATETTTVSLHWAVALMAEHPSIQEKIAMEIDEVVGRDRMPSLDDMGSLPFTEATILEILRYGSVIPFGVPHRVMADTTLGGYNIPKGTTVLINLFALHYDRSQWVEPEIFQPKRFLDSNGRLASQLPNSFLPFSCGRRVCLGKDFAQKEIFLLFTWLLSRYTIYKVPGKEGESLLTVKESAAFAHQPYDEIEVCVKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XT59</accession>
    <name>A0A8B7XT59_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein C5orf49-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110975675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084049.1">
        <property type="nucleotide sequence ID" value="XM_022228357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XT59"/>
    <dbReference type="GeneID" id="110975675"/>
    <dbReference type="KEGG" id="aplc:110975675"/>
    <dbReference type="CTD" id="100857376"/>
    <dbReference type="OMA" id="RKNGIAC"/>
    <dbReference type="OrthoDB" id="10057935at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027901">
        <property type="entry name" value="CFAP90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34444:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34444">
        <property type="entry name" value="LOC361192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15074">
        <property type="entry name" value="CFAP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084049.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16963" checksum="3D09D86DF76B7BCE" modified="2022-01-19" version="1">MNVVTAVLERLNEQGGDLNRHPGLMDNGEPIAAKSAFSYVPTVRDDPKEHSVFNSKQKSGPHSTYDRLFHKQEGYNNKLHRCDREHAKSKGLTVNDEEKEKIIPSLSSSEYGHRLQNFNDPPGRDHVRIAHVQTEFFSRTGINISNEMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUG3</accession>
    <name>A0A8B7XUG3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110975916 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110975916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084484.1">
        <property type="nucleotide sequence ID" value="XM_022228792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUG3"/>
    <dbReference type="GeneID" id="110975916"/>
    <dbReference type="KEGG" id="aplc:110975916"/>
    <dbReference type="OMA" id="YIKYSAT"/>
    <dbReference type="OrthoDB" id="6120813at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034288717" evidence="3">
        <location>
            <begin position="26"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="4">
        <location>
            <begin position="42"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022084484.1"/>
        </source>
    </evidence>
    <sequence length="140" mass="15495" checksum="2B415E95BC05F3CA" modified="2022-01-19" version="1">MEPKTNLYVCVALCLLLLTLPASDAYARRRRRRSVPVVRKTEDSQPPVLVSGTCPSSMTVYVDSPSSKQIVLWSKPQASDESPPVSLRREDDGPPNGGYFTASNSPYYIKYSATDAVGNKRMPICSFIVDIEVEDKKPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XUL9</accession>
    <name>A0A8B7XUL9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110975967</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110975967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084548.1">
        <property type="nucleotide sequence ID" value="XM_022228856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XUL9"/>
    <dbReference type="GeneID" id="110975967"/>
    <dbReference type="KEGG" id="aplc:110975967"/>
    <dbReference type="OMA" id="KRYNACL"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031941">
        <property type="entry name" value="DUF4773"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15998">
        <property type="entry name" value="DUF4773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034355953" evidence="2">
        <location>
            <begin position="23"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4773" evidence="3">
        <location>
            <begin position="89"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022084548.1"/>
        </source>
    </evidence>
    <sequence length="223" mass="24395" checksum="BBF0FAEA1DEA6086" modified="2022-01-19" version="1">MMRPIAVLVCTAFLCCVSLETTEDHPPTRESNTADAGSRTAEWDETAPSVWKEDQTGEVWDKGHLLSWLYGAQSQVNTPVIAKREGSSCSCSTETRDCRCCFKFTILGKKFSACLVGYYHQNDGIGVVVEINSQTIINRNVRVTDREVSLCKTFLTRGVCVGLNDIRLESNSISAHAKFEIQGIIDKNFGEIVIPIGAPSGGRGPSISPLLGHMLPSFLLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XVS3</accession>
    <name>A0A8B7XVS3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110976187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <dbReference type="RefSeq" id="XP_022084959.1">
        <property type="nucleotide sequence ID" value="XM_022229267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XVS3"/>
    <dbReference type="GeneID" id="110976187"/>
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    <dbReference type="OMA" id="YESFHYT"/>
    <dbReference type="OrthoDB" id="427071at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OGFOD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14650">
        <property type="entry name" value="PROLYL HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="8">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022084959.1"/>
        </source>
    </evidence>
    <sequence length="322" mass="36335" checksum="EB41F0CDDC233800" modified="2022-01-19" version="1">MAPRRRKPVSSETNEAGDSKKKHNHADKEAESSEEEVPRHRVTFRSLALRLLAIFFFLGLAHWYSAKAGPQTLAQQTETVHSRRFNVTCSSDFASDLKRFKGCAPTQCGRVIMDSLVSKSEARHLLELAKNGLQLGGSNGGASILDLHSGALSKGDSFINIYKYLEKSELGSVFHEGDFQLYSTVAKKIKLAIAKEFRIQPSKLYLTHPTFFSRMTNKPAKTIHDEYWHVHVDKETYDTFDYTSLLYLADYGKDFEGGRFIFTDKGTNMTVEPKLGRLSFFTSGSENTHFVERVTKGTRYAITVSFTCDKAKAIEHPKLRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XXI9</accession>
    <name>A0A8B7XXI9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110976191 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110976191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022084967.1">
        <property type="nucleotide sequence ID" value="XM_022229275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XXI9"/>
    <dbReference type="GeneID" id="110976191"/>
    <dbReference type="KEGG" id="aplc:110976191"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034955973" evidence="1">
        <location>
            <begin position="24"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022084967.1"/>
        </source>
    </evidence>
    <sequence length="194" mass="21494" checksum="476B8C0B72603ABC" modified="2022-01-19" version="1">MAMNLGKLLIILTVSVNITDVLSLGMDEEEARPHKTVLWDSIFRRIPVLGNVEPGPRYAVDDGFSKMSTSQLGADRDDIKLRFPCIYCQLFVTFIATVKSDERISEMMRAISELICVLWSPADSMNDCVDYAQQKTSLLHSMINGFMVECGTVCDGEGADEQLAVLGRMLQEVNRASQEVPTTEKPDIASLAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZS1</accession>
    <name>A0A8B7XZS1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA ligase</fullName>
            <ecNumber evidence="19">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26 27 28 29 30 31 32" type="primary">LOC110976515</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27 28" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="19"/>
    <dbReference type="RefSeq" id="XP_022085530.1">
        <property type="nucleotide sequence ID" value="XM_022229838.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085531.1">
        <property type="nucleotide sequence ID" value="XM_022229839.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085532.1">
        <property type="nucleotide sequence ID" value="XM_022229840.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085533.1">
        <property type="nucleotide sequence ID" value="XM_022229841.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085534.1">
        <property type="nucleotide sequence ID" value="XM_022229842.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085535.1">
        <property type="nucleotide sequence ID" value="XM_022229843.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022085536.1">
        <property type="nucleotide sequence ID" value="XM_022229844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZS1"/>
    <dbReference type="GeneID" id="110976515"/>
    <dbReference type="KEGG" id="aplc:110976515"/>
    <dbReference type="CTD" id="3980"/>
    <dbReference type="OMA" id="GRWCTVT"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070421">
        <property type="term" value="C:DNA ligase III-XRCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07902">
        <property type="entry name" value="Adenylation_DNA_ligase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18431">
        <property type="entry name" value="BRCT_DNA_ligase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07967">
        <property type="entry name" value="OBF_DNA_ligase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000085">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000003">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019406">
        <property type="entry name" value="APLF_PBZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031916">
        <property type="entry name" value="LIG3_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16759">
        <property type="entry name" value="LIG3_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10283">
        <property type="entry name" value="zf-CCHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 19" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15 19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="22">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="23">
        <location>
            <begin position="483"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="24">
        <location>
            <begin position="871"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="105"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="729"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="819"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="829"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="846"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="RefSeq" id="XP_022085530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="RefSeq" id="XP_022085531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022085532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022085533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_022085534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="RefSeq" id="XP_022085535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="RefSeq" id="XP_022085536.1"/>
        </source>
    </evidence>
    <sequence length="958" mass="105851" checksum="601DC0E6C1BE9EB3" modified="2022-01-19" version="1">MADNRYSVDYARLGTSKCKKCKQGIAKKEPRIAKLVTNPFSEDGGDMKQYHHVKCMFEALLRARPTTKKIDDPEDLEGFDVMEEEDKKTIKELIADLALKTKNKVATPSKKKTVQATLSASGHVVSPSKKVPTPSASNSDLPSTSTSTSVSSATTDISHSDNSFREFRKLCARIADQSAYLAKTREVETFIKKGSSGDGFQGDTYLLLKLLLPGVVKRVYNINSKQLVKVFSQIFGANLEEMVTDLDQGDVAETVQKFFSESAVFPPAKKSTLSIHEVDDFLEGMAALTKETDQQRHLTGIAKRCTANDLKMVVRLIKHDLRINSGAKHILEALDPNAYEAFQASRNLRDVVDRVNKNKEAADGRPGMSKKLSVRATLMTPVLPMLAEACKSVDMAMRKCPNGMFAEIKYDGERVQIHKQGDTFQYFSRSLKPVLPHKVVHIKDYLPKACPHGNSIILDSEILMVDKTGKILPFGTLGIHKKNAFSDANVCLFIFDCLHFNGENLMDRPMKERRKILEQNLTPVKNRIMLSESKDISVASDLSSLIMSVIREGLEGLVLKDKMSVYEPGKRHWLKVKKDYLAEGAMADTADLIVLGAYYGTGSKGGIMSTFLMGVHDPATDRFLTVTKCTGLDDQTLNQLNRDLAVDKISKDSAKVPSWLHVSRGLVPDFVVKDPKKAPVWEIMGAEFTQSDNHTAGGISIRFPRVSRFRDDKDWKTANNLERLKALSKKSKETSDIPDLISKKTASPAKISAQMHKRSKPASDVEEDEDYEGDTDEEVDEERKPSPAKKMKIDNGDGTSSAKGKPACKYGAQCYQTNPRHKTKYSHPAGSNGSPSKTVSPSKTQAASPSKPASIAPTSTVKPSMHSPAKGLANIFSGLSVYLPKTIADYYKLKRYVVAYDGDVLTDFNKANATHFVVDVNAEEKEATPPGKIGVTPAWIWECVKQKRILPASKFAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y079</accession>
    <name>A0A8B7Y079_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Histamine H2 receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110977069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086563.1">
        <property type="nucleotide sequence ID" value="XM_022230871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y079"/>
    <dbReference type="GeneID" id="110977069"/>
    <dbReference type="KEGG" id="aplc:110977069"/>
    <dbReference type="OMA" id="VCNQSAI"/>
    <dbReference type="OrthoDB" id="10042731at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="7">
        <location>
            <begin position="51"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022086563.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="41157" checksum="E714163D1C1C8D37" modified="2022-01-19" version="1">MDNATGVGLVRDLDSINDSMNSTENFAYESTSQTVFLLIVYGVIGTLGIIGNGIVILVYIFSPSFLRNVTSSIVCNQSAIDLAMSVIFVVINLGPQLNLPSDPAFADFLCKVWLSEYAIWALGASSTCNLVYLTIERHVAVFHPFYYRSKFTLRKARLICVIPWIVGPIHELGWGLTNRVINGTCTSQWPSVQMGLAIGFISLIDHYVIPLCIMAFVYSRIICKLRHAWRKADMPRSGARRRLVRQASRNVIITTFLVSLTYLVCWGPNEITYFYVNMGGDVNMSGMFFRFTVVVALVNMCINPFIYAMCYKDFRRGLWLCLRRNQAHNAPSPCPSHSHDHDVISSTTQGFHDARKMPRYKKTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0H0</accession>
    <name>A0A8B7Y0H0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Rho-related BTB domain-containing protein 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC110977126</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086662.1">
        <property type="nucleotide sequence ID" value="XM_022230970.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086663.1">
        <property type="nucleotide sequence ID" value="XM_022230971.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086664.1">
        <property type="nucleotide sequence ID" value="XM_022230972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0H0"/>
    <dbReference type="GeneID" id="110977126"/>
    <dbReference type="KEGG" id="aplc:110977126"/>
    <dbReference type="OMA" id="TIDKDCN"/>
    <dbReference type="OrthoDB" id="6020506at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18499">
        <property type="entry name" value="BACK_RHOBTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000177">
        <property type="entry name" value="Rho-related BTB domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="559"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022086662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022086663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022086664.1"/>
        </source>
    </evidence>
    <sequence length="761" mass="86578" checksum="F28E98F47AA11723" modified="2022-01-19" version="1">MDNELPRQELVKCVVVGDSSTGKTRLIVARATKRAMTRAQLFQTHKPSVWAIDQYHRCQEVLENSWEVIDGVSVSLRLWDTFGDHEKDRRFAYGRADVVLLLFSVADAVSLHNTTRVWLPEIRHFCPRAPIILCGTKNDLRYADLEALLKERGPVSHQCTRHRPFDPKGIVSPSEGRLIAKEINAFYYESSAYTLYGVDEVFDNVVRAALIARRHHRFWQSNLKKVQSPLPQAPYLPPCPSEPRIVVPPSTYNNDISSLLKDLTCADVTFVVQGEYIHAHKVCLIAASSVFHDLFMLDLSDQLDSSSSSQDPEGQSYDPGQQQHWSSPVPVPQQHMSTSPDIIETPPDNSEHHRLPQAHPHHQRSNCDRDHTSLLEDGCLSFSPNGNTCLISVRPKTRALPTGETPSPPQLSDPSDFEDSIEGDEGLTSLTVVPASLRYLPSKVLSHPAFHSIHLQQAEDPITGRPKLRSVVVLNYKITPEAFRAVLGFLYLGSLSPEKYTNLSDVITAASLLDLSDLVSAIANIKHQEEYMNLEIAEAFLENRRDRFRELFADKGFLSDMVIKLDDGAVVTHRSLLMVRCDPMLAMLSRHFKERPCQEVILQGFRKSTFKAVLVYLYTDQCPEQLTRSEMLSVIELANFLCLPRLVALAEQCLVLSFREEAAEKDGDIGENVSHLLDTCKVHNANQLYHWCIHHMAIHYDAISKKHPRLLRDISQEACKEIHCQRWPPLYYLNEIEEYEQQQREKKRLADRSKKHKWCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y141</accession>
    <name>A0A8B7Y141_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110976591</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110976591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085686.1">
        <property type="nucleotide sequence ID" value="XM_022229994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y141"/>
    <dbReference type="GeneID" id="110976591"/>
    <dbReference type="KEGG" id="aplc:110976591"/>
    <dbReference type="OMA" id="QNMTRRQ"/>
    <dbReference type="OrthoDB" id="10638657at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="633"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022085686.1"/>
        </source>
    </evidence>
    <sequence length="1110" mass="119903" checksum="582D7C105977133F" modified="2022-01-19" version="1">MDGSSDTETIVEESVDQCDSPSILTGLSQIRRMSQTHQPLKSRGLLEKISRAFVTSASSPSGKDDSGTHSSRDDTSFVDLSQSSEKSQSIFTQRVSAKRKSPILTVPPSSSQGPSLKIPRSADDSLSIDTHLAVQSSSFGIQADHGQVASFSSSLALLLNEQTQATVTNISPVEQKITWRPNHPEASQWQTTNSVTVPERTNLVKEGADQLGVQELASRNRSPGLTEATPPSVPTLSQRQAIAMPEAIDSNLITTLPTLTPLSPEAQDCHTVFSSTSLLHQGSFLKVKGSEKDEDDDSLFEVEKMQREIREKLSSKDADVKYTEQVKKSLQDVQARLRRLSARQRDHRHQLNIKLKQQATAPSNKQQQQEARTQLQNMTRRQQHLLKLLQSHKELTVSLQWMQHAKHPLPVQNEVSGQSRSVNDSTLEVEPTGTKQSSSPKIPSINSFLPDREAMLMSNDKAAIPASSNPLSAQTSGTKIPSKPASDISSGRNFKPPFKANTAKSPNQPVPPSSSYITLNLQRDEANSVSVADIQDRAQSIPRSAVRDKSPEPITEEKISPKSPPYLPWLSPDKSFIEPSKEQSKDSHQAAIPLQTEGLPVALVTDHYATSQGTTLPPGFPSEPLSITHLSTQAGNTTETAPSTSRSPALVSPVPKTPHQSSIQISTVPTDCKRHGDQLPTQLSNKDPGSPKSLKAPGSTPSSQPRQMVVYKINASTVKDLQKRNPSKTSLDAVIAGMPGSSSTVQTSCQVDSVTGSTQLLSNTTCLSSPSSSCCTVAAATRTNIPSNSDILSPPGTVEVTTAGLQSQMDVMTQGEATGLSACQTRAPSDPQGTAEVQAQTGSQGRTTVVDSSSQKNKTLPNHNRRAHSTEEEVPSLQNLLQERLIQPGENVLLVKLKRKAVSASLTIDGTVRPTTVLKNFTCGSLHQLVSMVQHKSISWIRKNPSIWKSVLYKDKPLEQLHADYKALLARDHQFQSQQVAVKQNTQATATTNMMTTHASVHVPPTSGNHTSSAHAPPRRQTLVSTGLDLSSQSGVRVARSSDLTSAADCDITTSLSNSSPIRAGLASSMEKVLLISDGELMPAPWGVSSDNTQNSSIPQEWIDEIDIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1X1</accession>
    <name>A0A8B7Y1X1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110976898</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110976898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086290.1">
        <property type="nucleotide sequence ID" value="XM_022230598.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086291.1">
        <property type="nucleotide sequence ID" value="XM_022230599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1X1"/>
    <dbReference type="GeneID" id="110976898"/>
    <dbReference type="KEGG" id="aplc:110976898"/>
    <dbReference type="OMA" id="MRTCHTA"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665498" evidence="2">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086291.1"/>
        </source>
    </evidence>
    <sequence length="139" mass="14575" checksum="C1A1E94DBD472E72" modified="2022-01-19" version="1">MNHLAIASFFYFVAVFTLSGVEAQSTGSLMCYNCTYTSVLGFDVGEKGCSDPFNSAGISDISCDGSCVKQKLEGNIPSTTRSCYTASEGDCIQLNGVEISPGNHLYQYCCTGNLCNSAASLTFNFVAVASLCGALAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3R4</accession>
    <name>A0A8B7Y3R4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1</fullName>
            <ecNumber evidence="6">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110977397</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022087177.1">
        <property type="nucleotide sequence ID" value="XM_022231485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3R4"/>
    <dbReference type="GeneID" id="110977397"/>
    <dbReference type="KEGG" id="aplc:110977397"/>
    <dbReference type="OMA" id="SEGPKCC"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000017">
        <property type="entry name" value="Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="20">
        <location>
            <begin position="112"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00059245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022087177.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40174" checksum="747D2CED93296229" modified="2022-01-19" version="1">MARAIWSAFLLLVAFATGGFFTRMLTTYLHQENHYQLQLAKILDANHRSLISHATKESPSWITQPGLNRAFGPESASTDNSNHGTHHLPYPAKTSIPARILCWVMTSPTTLYTRATNVQETWGPRCDVTLYMSSQTDPDFPAIGLDVAEGRSALWNKTKSSFRYIFKHHLNDADWFMKADDDTYVIVENLRLFLQDKNSSAPVYYGHRFRPYIRQGYMSGGAGYVMSKEALSRLIAQLKAKKDCGAYQGMTEAAEDVTLGLCMMNSGVLAGDSRDEKNRSRFLPFDVETFFKNSQPDWYFKFSKYRVKKGRSCCSDSLITIHYVKDRTSMLLLDYYLHGLHVEPFVNSKNIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y3Z5</accession>
    <name>A0A8B7Y3Z5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division cycle 20.5, cofactor of APC complex-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110977783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087909.1">
        <property type="nucleotide sequence ID" value="XM_022232217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y3Z5"/>
    <dbReference type="GeneID" id="110977783"/>
    <dbReference type="KEGG" id="aplc:110977783"/>
    <dbReference type="OMA" id="RIADHKV"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022087909.1"/>
        </source>
    </evidence>
    <sequence length="502" mass="54759" checksum="BBF0A6DDD3740AF2" modified="2022-01-19" version="1">MQTGRRALDVDYFGRTWELPSLAMIGIHQEQQRGRAGSFDRFIPARDRLNFAAASYEVSPTPGSRGRADEDGASSQDVFFESKSEANNSDSVWKFGESQADYQQRMALLAEGVVCDKVFAFRPRQRSGSWSGYRDVATSKLPCRKLPPSPTHALEVNALNTARVGSSQLFDINSRGQLAMLLGRQLHVLELGQADVRFKSFTVSSEPAGRDDAHHTPCCVRWSPTGRAVAVCAQALLLFDPELGRITASSIDFSPSDCLDWSRHCLSAGYSDGTVKVYDTRCSLSPVGYFTTSSRLSAVNTLRYSTDGGMLACGTADGKVVMWDVRHRGKPQHELDAHSDGVGAMAWCPLKPWYVTTGGKASDQTIRIWNVYTGILNKSIMVGSEVTSLAWCEQSSELVSSHGTESGEANIRVWKSPKMHLVGEMRRHEGRVFQVGLTPDGSKLISVGNDEILCVWDFYHADAASLASPLGTAHPRRRSSTFNSPGKSPGAVTSPLALGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y508</accession>
    <name>A0A8B7Y508_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110977639</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110977639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087622.1">
        <property type="nucleotide sequence ID" value="XM_022231930.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110977639"/>
    <dbReference type="KEGG" id="aplc:110977639"/>
    <dbReference type="OMA" id="CPANING"/>
    <dbReference type="OrthoDB" id="10066451at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.960">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000082">
        <property type="entry name" value="SEA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036364">
        <property type="entry name" value="SEA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273">
        <property type="entry name" value="FI04643P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24273:SF32">
        <property type="entry name" value="HYALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01390">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00200">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82671">
        <property type="entry name" value="SEA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50024">
        <property type="entry name" value="SEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="3363"/>
            <end position="3389"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="72"/>
            <end position="164"/>
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            <begin position="165"/>
            <end position="245"/>
        </location>
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            <begin position="246"/>
            <end position="332"/>
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        </location>
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            <begin position="414"/>
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            <begin position="497"/>
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        </location>
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        <location>
            <begin position="576"/>
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            <begin position="659"/>
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            <begin position="737"/>
            <end position="819"/>
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    </feature>
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            <begin position="820"/>
            <end position="900"/>
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            <begin position="901"/>
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    <feature type="domain" description="HYR" evidence="9">
        <location>
            <begin position="981"/>
            <end position="1058"/>
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            <begin position="1059"/>
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            <begin position="1141"/>
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            <begin position="1226"/>
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            <begin position="1305"/>
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            <begin position="1550"/>
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            <end position="3355"/>
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            <begin position="3419"/>
            <end position="3441"/>
        </location>
    </feature>
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            <begin position="3151"/>
            <end position="3160"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022087622.1"/>
        </source>
    </evidence>
    <sequence length="3496" mass="372869" checksum="E35E429507374486" modified="2022-01-19" version="1">MGLSTAVVIWSPLPSATDNVDVFDSSNITCKDEDGNVVESNGTYALGPTTVTCNATDMAGNRGICNFSITIIDTEAPNVTCPSSIPSMSTDMGLSTAVVIWSPLPSATDNVDVFDSSNITCKDDAGNVVESNGTYALGPTTVTCNATDMAGNQGFCNFSITVIDAEAPVIDYCPQSVVNETSEATFSSIWTPPNATDNSDPAKNLTILSSHNPGDNFTAGTITEVEYIFIDTSNNSAVCIFNVTLSDIGDPVFLTCPDRLVFTLAQGQDRILVNFAIPIVEDNSGEVIVPVSDPQLMLPTDFSYGETSIRYNATDSSGNRAVPCVFTVAVQDEEDPKFTVCPQSPVSPITTDPNSNTANYSWVAPMATDNVAVMSVDSSHTSPAALPIRNNTITYTATDPAGNTGVCEFYVTIIDVEPPAVSRCPADIINSTDRGSSNATVYWQEPIFSDNDGLFTNTSTHSPGDPFGVGNTTVTYNVTDVSGNLANCSFLVTIKDNEVPTFVNCTEVILTGTDPGKATKNVTWATLDYRDNVGIDNIVSSHKSGDTFGLGNVTVTISVSDEAQNTANCSFVVTVIDDEPPSFKACPADIINSTDAGLNSSVVYWQEPTITDNVGVVANYRSHSPGDVFPVGNTTVIYNASDSAGNTNNCLFSVTVEDDEPPDLVCPVYVVNSTDANQNSSIVFWQEPRFTDNVGIVSNESSHRPGDVFPLGNVTVTYSVSDKAGNVANCSFIVSVEDNEAPNVMNCPADVVNSTMANQSSAFVYWREPSFSDNVGVFSRDNSHSPGNVFTFGNTTVTYTASDAAGNVRNCSFIVIVQDNEAPTVSNCPEDLVSDTDPALASSIVYWQEPTFSDNVAIVGNESSHNPGDVFSVGNTTVIYSVSDSSGNTLNCSFFVTVEDTEAPMFSTCSSVTIEVDPGQATSMQEWMFPVATDNVAVTRNSSTQQRGGSLSLGVHEVTYVVYDAAGNNNTCVFEIIVEDNEMPNITNCPMDVTLNTTRGRPVVTYSFPTPVCIDNAGSVTVTTSKLDDEYSIDDTTVIIACLDEAGNTDTCTFTVTVQDVESPRLLMCPTNVEAFADPGMNVSISWTPPTAEDNSGWVTVSSTHRPGDGFMNGTHTVIYTAKDPSGNMVSCNFSITVYASDKVAPMVVQCPNDTTVSADPGVNFTVVTWPPIVINDNVGVTALDRPMSYPNGSVFYIGSVTVSYRASDLAGNKGSCNFTVTVVDTEAPVLTNCSGDIVTFTELNSNGTISVSWDDPVVMENDVYSVTQTPSPGHFYSVGNTTVTYFVEDSSGLNDTCEFLVTVLDNQPPMFSNCPSDMESPTDAGAANATVVWTEPDANDNVAVISVTNSSAPGTVVGLGDTLQVVYIAYDAAGLNDTCLFEITVVDEEDPDIKSCPADVIVNATAGTSSAKVFWDEPTATDNSGTVTLTAAIRPGNVFDIGKMTTTYIALDEAGNTDQCTFQIIVQDVEDPMLTMCPTDINIYTPPGTNISITWTQPRVVDNSGDVTLSSNFNPGDKFANGTYLVIYTAVDPSGNSDNCSFIIQVNSTDTNPPMISCPSDVMVPADNGTNSTTVTWPPPPYMDNHRVVSVNVSKANGSLFYLGTKVVVYTVYDVAGNNDSCSFNVTVLDMQIPIIMNCPGDVNETTAPGQPTVNISWTEPTVSDNSGSFNIDQSHSPPSIFPVGPTKVVYLVNDSSSNLAMCAFNVTVTDDESPVFNCPLNVTNSTLPGRYVGTFFITLVATDNVKVTYSNSTHQPGDELDVGNTTIEFYARDAAGNEAVCQFTVTIKDDENPQIINCSSDIYTNTSQGSNMAFVEWTKPVAVDNSGMVTLTNDSNDSSMYPIGSTVIKYNASDSSGNLETCQFTVFVSDFEDPQVTCPPNIEAFADNGTNVRLNWTMPTATDNSGMVTLNFTHQLNSEFPLGTTYITATASDLSGNSASCTFTATIYPTDVEMPMIICPPDVSGLTDQWMNSTNLTWIVPQYRDNQEIVVFNVSHQNGSRFTIGTTVVTYFIADRAGNNASCSFNVTVVDAEKPVFLDCPSDVFIMNNESRVVNFTQPEVTDNSGGPVNVTSNYPSGTQFPFSDTIVIFTAEDKSGNRATCNFTVSVDDSEAPVLLNCSSNIDLYLYNDSANATANWTEPMFSDNSGVFMVDQEFFPGDQFPVGVNEIVISATDEAGNMVACVFNVTVIDLSPPVIVSCPGNMSTNTDPNKPTANVSWPLAQVLDNVEVASVIVTQEPGTAFPIGTTLVTYTATDSSGNTDQNDCRFYIHVSDNEAPMFVNCPSHMMFSTDVGVGEATVSWTVPMATDNVNVTFFEASHRPGDNFSLGPTEVTYRIADSAGNNNTCSFIITINDEEGPVFQNCPDNVTVATDPGSDMAIATWNTLVAIDNSGAVITPTSNSRSGDSFAIGSTTVLYIALDPNNNIGRCEFEVIVIASDMLMIACPADLTLFTDPSVNSSTASWPAPVFNSSIVVAVNSSHANNSRFEVGHTVVIYTITGKDGRNASCDFFVTVIDNESPVFSRCSSNVVSSASPSMATGTAFWVAPTASDNVGVTNLTSNYEPMAVLPIGSTVVTYMAIDAAGNRANCSFSAIVVDNEDPVFTFCPVTLEFMADAFGNVIVPTSGMPIATDNDGPPSVSTNYNLAMLDVGSTTLVAFTAMDDAENMATCNVNITVIANSGDSPPLFTSCPSNIVVSTVMTQSYALVTWAVPQAQDDRSTPIVIEQSGYMPGRQFAIGMWMVIYVATDSIGQTAFCEFNITVLDQEDPVIVRCPANINGVTINNAPIVVSWTPPTASDNSREFTLQANDNHAPGEMLNVGMYDVIYTATDPSGNTANCEFQITIENDAPPEFISCPSSTVVPTDPGQSYATVSFSYPNPTDDRSSPMLFGSHGPGTQFPIGDTTVTFTAYDSASQSAQCVFVITVEDRGDPVIMDCPSGQTVYVLSTSDVAAVYWTSPTANDTNNFTLTSNRNPGDEFETGSTQVTYTATDMSGNTDTCSFSVVVQETLPTYETTGSVALIRIGSMTSPFVANDVQTTLPGLRSDMDRLFRTSSVSDDFVGITVTGSSVETSDKALIEFVIYFAGSPAPNDTQISDAFYAALGPLENQFDTGNQIDPGTFMLSLTTCQQTSCQNGGSCVPQENSFVCMCTLFWTGDYCETDINECVENNPCAADRICINLQGSYLCGCQAGFFLVGDTCLATSEFSGSFAITRIGSSEAIFTRDLEDPTSDQYQRIAGDVIGVLDSIFADESSYIESHVVSMSSGSIRVQYVLVFTEDTNVTEDVVTNQMRASIAADGEIASSTLYIRLSSLSVARHVCPAGYCKNGGTCSPDPVTYESTCICESVYSGSRCEIHNAWSPLVIAMVTVAGILLLILVGVFISCCIFFHKHLEETKGPKHAGDVEGRDSFLKVSQPVLPWRSSSPSTDEPPHHPRGSHVSTSFALQSTRLDAGAGCYRRSRDDVPNGQQSSMFIRPYVVTGQEAAMSSTTVLNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y687</accession>
    <name>A0A8B7Y687_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC110978216</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110978216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088724.1">
        <property type="nucleotide sequence ID" value="XM_022233032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y687"/>
    <dbReference type="GeneID" id="110978216"/>
    <dbReference type="KEGG" id="aplc:110978216"/>
    <dbReference type="OMA" id="TIMICAN"/>
    <dbReference type="OrthoDB" id="6134459at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15039">
        <property type="entry name" value="7tmB3_Methuselah-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053231">
        <property type="entry name" value="GPCR_LN-TM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45902:SF1">
        <property type="entry name" value="LATROPHILIN RECEPTOR-LIKE PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034137170" evidence="9">
        <location>
            <begin position="22"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="938"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1034"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1060"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="11">
        <location>
            <begin position="155"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="12">
        <location>
            <begin position="274"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="10">
        <location>
            <begin position="830"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1098"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1098"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1119"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022088724.1"/>
        </source>
    </evidence>
    <sequence length="1139" mass="125212" checksum="1C74A6D1398AFC30" modified="2022-01-19" version="1">MKTNFWNIVLTIFGLATPSFHQLMPLTGRISTDHFRLIGGQDLNEGRLQIAHANDGSWSTVCTDVNAINDAIGFALCARLGYQVACKYGTGAEFSSPDVDLGSVEEVSFGNCDIGSTYTEQDCDITGIPSVNGACSSNTQDLWLHCTSGPGELELRLANPLSSFTGTVQARCRGSQDWASVCYSYSWDRRDAEVACRHLGFSFAAERAVISLANLEPTSIPSRVVISEFGCAGNETDLLECRLGLTRTSCTSVPRLSCGIETSEYGSQVGLCGNRHLCGVECSQQRDTTSVPRRGCHCDDVCLIFGDCCYDYEENCNSESREPPTSLNGLPINWFGCVEVPGFDTTFMGYFLVEICPEDWLGSGIREMCESPANDSDVFRSIPVYNNITFIQYKNIYCAVCHGERHDQVVPWSVEARYSSDRGGLPFLPNFDVGPPAFGTYTGKFVVRAPDRSGIEIRQCSTPAIDTCLEEYRGSLTEQGCKTYSASMAYRPSAFSGTITNYRNAYCGKCNNLTLSQGDSCDYDYCEELCGDDPWGRCFRRCAAPEGFLTIDVLFSFSSQGSSIAGVDSCMTGELYDPFLGSCRLLSCSSGYEIIGDECVKVVAPPTVEPDQPKPGTVTAFAYNSNNTVNVDLADCLRALLGPKTQGIVYWDANLDSASGNVAVNFLTENETTLYDVSEALNLLVHSSWCNATRVAFFLEFEYILPLDHCLNFVEVGTDLFQAHFGQDIRTKVVRLSQFNYNTSTSVYNFLKTDSACLDNSLTCPILTLNSSDIEKSEIGNETVVKYIPSGLVLPLGMYVVLADGSAAACADAVIQPSTPGPPTTTELAYRYLYLVLTILSLVALAATFFVYSLLPTLRNLAGRCIMNLVVALFLANLLLLLNGFFVEVPTLCLVAAPVIHFTWLAAFMWMLALSINVARTITSKVVNKSEESETRPLLLYMLFSWGTSLVIVGICIGLHFCQCVVTGSIYASEISCYIVNPQVNLYAFGIPVAVTLTVGICLFLFTVVNLRISRSATRVARNETRMQEAKVEFVIYTRLSVLMGMSWVFGFLTQVIQGYAMLFVFVILNSLQGFLIFLSFCFTARVRKLLREKYGRRHRSDGRRRTRRKPTDLVDASGTHSQINSHQSHSANTDTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YAF0</accession>
    <name>A0A8B7YAF0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock 70 kDa protein IV-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110978560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089350.1">
        <property type="nucleotide sequence ID" value="XM_022233658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YAF0"/>
    <dbReference type="GeneID" id="110978560"/>
    <dbReference type="KEGG" id="aplc:110978560"/>
    <dbReference type="OMA" id="EQFCSPI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022089350.1"/>
        </source>
    </evidence>
    <sequence length="638" mass="70332" checksum="CCD63DC39D14E782" modified="2022-01-19" version="1">MAPSQKAPAIGIDLGTTYSCVAVFQNGKVEIIANEQGNRTTPSYVAFTDTERLIGDAAKNQSAMNPKNTIFDAKRLIGRRFDDASVQADMKHWPFKVVNKQGMPILQAEYMNETKTFPPEEISSMVLTKMKETAEAYLGQKVKDAVITVPAYFNDSQRQATKDAGMIAGLNVLRIINEPTAAALAYGLDKKLSGEKHVLIFDLGGGTFDVSVLAIEDGMFEVLSTAGDTHLGGEDFDNRLVNHLVEEFKRKYKKDLTTNPRSLRRLRTAAERAKRTLSSSTQASIEVDSLFEGIDFYTCVSRARFEELCADLFRQCLNPVERALVDAKLDKHLINEVVLVGGSTRIPKIQKLLQDFLNGKELNRSINPDEAVAYGAAVQAAILSGDQSSEVKDVLLVDVAPLSLGIETAGGIMTKLIERNTRIPTKTSKTFTTYSDNQPAVTVQVFEGERAMTKDNHCLGVFELSGIPLAPRGVPKIEVTLDIDANGILNVSAKDESTGKSNQITISNNKGRLSKEDIDRMVSDAEKYKAEDEAQRERVTARNNLENYIFSVKSTLSEEAVQTKIAVEDKEKAENLLQEILAWLDNNNLADKEEYQYKLEELQRVCSPVMAKLYSAGKGNQEDVSGGHQQGPTVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YCS3</accession>
    <name>A0A8B7YCS3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sushi domain-containing protein 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110978639</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089466.1">
        <property type="nucleotide sequence ID" value="XM_022233774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YCS3"/>
    <dbReference type="GeneID" id="110978639"/>
    <dbReference type="KEGG" id="aplc:110978639"/>
    <dbReference type="OrthoDB" id="6051552at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005533">
        <property type="entry name" value="AMOP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056619">
        <property type="entry name" value="C8-3_MUC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051495">
        <property type="entry name" value="Epithelial_Barrier/Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035234">
        <property type="entry name" value="IgGFc-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802">
        <property type="entry name" value="MUCIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13802:SF52">
        <property type="entry name" value="MUCIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03782">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23263">
        <property type="entry name" value="C8-3_MUC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17517">
        <property type="entry name" value="IgGFc_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00723">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50856">
        <property type="entry name" value="AMOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034769502" evidence="9">
        <location>
            <begin position="35"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1164"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="AMOP" evidence="10">
        <location>
            <begin position="680"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="12">
        <location>
            <begin position="826"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="1094"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="1122"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022089466.1"/>
        </source>
    </evidence>
    <sequence length="1191" mass="131164" checksum="2F4EA1F3FEFB5368" modified="2022-01-19" version="1">MLRHIKSMNRLVKVRFSWLAVCMLFALLEMQVSAVDLQLPDIDKPTCSGISRGKHFVIGFTDNTNEYLDTRQLYILVVAFSNQQTDVTISSKFLLDERKYQASFVIEAGGFRRVTVPVELTMNGDERSMKGIDIKASSEVSVYGLIYQDYTTDGFLGIPTNNLGMQYVVVTPTGNVLPSQFAVIGTEDVTSVQVILRGAVTFEGKIYNAGDVLTFMVDELEAVHIQGRDSGQDLTGSIVQANKPVSVFSGNECVRQGGSACDTVTEQLVPVKSWGRKHIYTAARETDRNIYKLVAYFNGTVVSIPGLRDRSLDPGEFWEGGLSGSGVVYSSKPILMMQLLANINGRTVDPSFIQVPAEEQFGYVFGFTTPPHSGGDSGGYFNFFNIIVRNDSRQSVYINGYPINSTNVFERYIPDTNYLSLTIQPPKGEGVYFVEQTNPESSPLSITVFGYESSESYGYAAGLSLPSNTHLLSFTPYYLRELGGEIFTITVSCLQTNAIFYQDAKCRFSTGFGDVEVPGERTDSYTVICITPTFYKNGLTSVYVSLDNGKSFPYSGIVYVASEEDLPPLVNVQQMNSEYGNDIIDLTSKSPILLSWDPRSLGENVSHVTVMIQDTDYNSDGNPVLMGGVALKTNVPNNGILTINPSDFTSLSDAGVSLSALYLTPYAVRNRIWPIIRLGMRIYKLLKTVTKVACFISKFTFGNDIPDDLPSCPCDTTQAEGDLLNFQREDSLFNFIIQPGADVCYRSINSFSSQGGQKCCYRKDGNILLVPPGAGTAERYSAVHHPWLHLWYDVLPWFCLCIRSNKCKEFYKNRPSDDCSGYDPPRPAGGTGDPHLTSLDGYKFTFNGAGEFLMVSSDLHNLTFQARMERYRNTNASVYTAFVLQTNDSSKVQVQMSNMNETLILVDGEPLRLDSIPVRVHHLEGVQVSFNSDLSKINIAFSAGIAIIVYIDPEMMSFIAQLDTKFQGQVRGLLGNLNGNPDDDLQFPNGTVMDPGSSLKELHEFGLEWLVKEDNSIFSYISPFDYSTYHFPEFSPTFEVPDVNEVSQEIKGFCGDSIECVFDAVVTGSLSFANETLMATNTINEVRKGLVKIVSCGFPGDVENGQMWGSVYLVNATVNVTCNENFALEGSSRLTCQADGQWSSDLPVCVFTGDRGDAPKGLSAGVIAAIVVGTLIIVLVVAGVIYFLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDV6</accession>
    <name>A0A8B7YDV6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110979704</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110979704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022091438.1">
        <property type="nucleotide sequence ID" value="XM_022235746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDV6"/>
    <dbReference type="GeneID" id="110979704"/>
    <dbReference type="KEGG" id="aplc:110979704"/>
    <dbReference type="OMA" id="PHSQSWT"/>
    <dbReference type="OrthoDB" id="10020219at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022091438.1"/>
        </source>
    </evidence>
    <sequence length="134" mass="15349" checksum="140595080B1DB8CD" modified="2022-01-19" version="1">MSRLPAGGQQRHVEYDMPESCSSSSVGLPHISLRGNLPHSQSWTVVPEYNMSLRQQKEIDPFEYWKCDVQSQIANMADKLRNSLEQYPDPSTRYLKADGRSSVVESDFERRKAEQLKQQTRTITNSLAYGLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE14</accession>
    <name>A0A8B7YE14_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979756</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091494.1">
        <property type="nucleotide sequence ID" value="XM_022235802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE14"/>
    <dbReference type="GeneID" id="110979756"/>
    <dbReference type="KEGG" id="aplc:110979756"/>
    <dbReference type="CTD" id="6189"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091494.1"/>
        </source>
    </evidence>
    <sequence length="267" mass="30237" checksum="E458C911F0C6FC14" modified="2022-01-19" version="1">MAVGKNKRLTKGGKKGTKKKVVDPFTKKEWYDVKAPAMFNVRNIGKTLCTRTQGTRIASDALKGRVFEVSLADLQNDEVAFRKFRLMVEEVQGKNCLTNFHGMNLTRDKYCSMVKKWQTMINANIDVRTTDGYLLRLFCVGFTKRRQHQIKKTAYAQSTQVRAIRKKMVEIMQRECSSSDLKDVVNKLIPDSISKEIEKYCQGIYPLHEVHVRKVKVLKKPKFDISKLMELHGEGKNAAAPAAPKPGADGTTVERPDGYEPPVVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YF01</accession>
    <name>A0A8B7YF01_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Sodium-coupled monocarboxylate transporter 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110979462</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71207"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090965.1">
        <property type="nucleotide sequence ID" value="XM_022235273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YF01"/>
    <dbReference type="GeneID" id="110979462"/>
    <dbReference type="KEGG" id="aplc:110979462"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098660">
        <property type="term" value="P:inorganic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11492">
        <property type="entry name" value="SLC5sbd_NIS-SMVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="527"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="588"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022090965.1"/>
        </source>
    </evidence>
    <sequence length="645" mass="70247" checksum="09B3E3CF1B9F21DA" modified="2022-01-19" version="1">MVAAKLELRVFSGADYAVFACVLLVSCGIGVYHALTGGRQKTSKEFLMANRNMNPFPVAVSLVASFISAITFLGTPAENYIYGCMFWLYGFAYSITGIIVSRAFIPLFFRLNVTSAFEYLELRFNKVLRICGMMTFFLQMIIYMGIVIYAPALALSAVTGLHLWGSVVAIGLVCTFYTTIGGMKAVLWTDVFQVCIMISGFLALIIAGSMRLGGITNVWNIAEEGGRIDFFNFDPDPTVRHTFWSVVVGGTFTWSAVYCVNQAQVQRYLTCGREPVAQLALFMAVVGMVIVVSLACLAGLVMYANYAGCDPYTLKYVDSTDQLVPYFLMDLFHESPGLPGLLVSAVFSAALSTVSSGLNSLAAVTGEDIVKTIRPNIEEEKYTKITKCLAAGYGLLCIGMAFIASLLGDVLQAALSIFGIVGGPLLGLFSLAIFFPWANSKGALTGLVCGLVFTFWIGIGAQIYPPANPNKPLLSVDECPVFNSTEATWNATGVLATEMPTTMMNYSTPLPEPTERPAIAQLYAVSYAWYSAIAWLTVIGTGLLTSFLTGYTKPSEVDPRLLCPVVDAMYCCLPEKLKKPLRCGARKYEPEGDEEKAISTDEKNEKEKYKPDETDKAGNGESYQVVTDELPPPYPNGQMEFNTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YG59</accession>
    <name>A0A8B7YG59_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pancreatic triacylglycerol lipase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110980154</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092224.1">
        <property type="nucleotide sequence ID" value="XM_022236532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YG59"/>
    <dbReference type="GeneID" id="110980154"/>
    <dbReference type="KEGG" id="aplc:110980154"/>
    <dbReference type="OMA" id="VIEWDYW"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000033">
        <property type="entry name" value="Pancreatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002331">
        <property type="entry name" value="Lipase_panc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF173">
        <property type="entry name" value="LIPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00823">
        <property type="entry name" value="PANCLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034011578" evidence="8">
        <location>
            <begin position="17"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Lipase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022092224.1"/>
        </source>
    </evidence>
    <sequence length="493" mass="55093" checksum="B415A27CE6409034" modified="2022-01-19" version="1">MQPIVLLLVWLPLVFAENRAKEVCYSNIGCFNYGYPFLDPPQRPLSWAPQSPSRVNPRFLLHTRHNPLKDQAQELYIDNPSSITSSHFDPSKETKLICHGFLESNVIEWDYWMTNMMKEFLNYADYNVIKVVWGSGSMFPYTQALSNTRIVGAETSRLIDKLRALYGISAASFHFIGHSLGSHIGGYVGERQSGLGRITGLDPAGPGFENTQPEVRLDPTDALFVDTIHSDAKNILELGFGMIAPVGHMDFYPNSGSSQPGCDQSLFEDFFDEGLIGGGVKFVACNHMRAHEFFTQSINNCPIYGFSCPNGADSYDSFVNGECFSGDVAPMGFHSINYKPSSGVTLRKYYTATTDTSPFCMQNPFQIGLHFDDPWYAETFKGWAYVTLIGGGGKTTRTKLNENSLNFKPGTDLGFVFNTNTDPGSLSELQFYWDHDFELLNPGDWPIFDDIEVFISKITIKGLSLQKSYTLCNQKPNTGINSNTVAYFRASYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGF7</accession>
    <name>A0A8B7YGF7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Telomere length regulation protein TEL2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110980202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022092323.1">
        <property type="nucleotide sequence ID" value="XM_022236631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGF7"/>
    <dbReference type="GeneID" id="110980202"/>
    <dbReference type="KEGG" id="aplc:110980202"/>
    <dbReference type="CTD" id="9894"/>
    <dbReference type="OMA" id="FYPQNYF"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000001">
        <property type="entry name" value="Telomere length regulation protein TEL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057348">
        <property type="entry name" value="TELO2_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25320">
        <property type="entry name" value="TELO2_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TELO2 ARM repeat" evidence="6">
        <location>
            <begin position="340"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="5">
        <location>
            <begin position="528"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="474"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022092323.1"/>
        </source>
    </evidence>
    <sequence length="849" mass="96243" checksum="9FC00DF0517EC3F6" modified="2022-01-19" version="1">MADTKLSVRQTVRESQNILTSSRDSTELCRALERISALLPGWNGNNVTTLGTPSEAAAEFGASHYVRFLEFLVGQFSLDWCSRFTVEERDSLIDVFFLDGVHHHAFLVLCTAVTQSSPSFKQNKCLSLLEDFLLRGRMTDIIWTQCCILSDLTDSGTQSAKHRVLWEQLLTVIVSLPDRVANRMQDKCSISFHPKQYFTSLAKDLVVVLHKVYNQLKATQDCSLLFVSQLIGRICLNGHADTILSFLLPHFVKFTADDFLWCRVCSRIIVGTPERCMESIMDSLLKKIPWYGIVSRLLGDAVLSNKKLLFLLTNKFLLLRCYSQELVPQNIIGYLADSPNRRHLVVKTLRTLLDVWGDSSAVKHTAYDQHAYLTKVMLICLGHLNQQEKAKHKSVLMQKLLSGMQCHLNSPLHKVRRLGMIAAEALTKTLEAEGPKLTFEYEKDEESRLLWSLLVPPKDPGIEEITKDVVEMSLSEEERKRENAAFGKSEQKNVSPLHPSQDNDLDSDDDLEPYDMSEDVKTSQVQTPMYIRDCIEGLHAKENRELTETSLKVAEKLARSKPDNLPEVCVEFLQVLLHLEDIYEIDDFMVLRHSAMVAATVLCPIQASQYLTTEFYDRNYNIRQRLDVLEVLAAAAQELSQPLEATAPCSGIQKPRRPLTQAAPNPSEEAEHWRDIVQKRIESKTRRFAKGRSTPAPIPIASRFAPVAGYFFFPLLKSYDSNLNTMDMMGDDFLLLGRMLYTLGIVVHAAQHAPICRQMAVSLLELVWTLRYHTEVFVRQALMFAVSMVILSMPSHLLISDLQDEMLECKLWLEDIVGKDPNAECRDLAAQTLMVLGSVVHKELNAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIK6</accession>
    <name>A0A8B7YIK6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">BUB3-interacting and GLEBS motif-containing protein ZNF207-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022091451.1">
        <property type="nucleotide sequence ID" value="XM_022235759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YIK6"/>
    <dbReference type="GeneID" id="110979718"/>
    <dbReference type="KEGG" id="aplc:110979718"/>
    <dbReference type="CTD" id="7756"/>
    <dbReference type="OMA" id="CERAKCH"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022091451.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="52781" checksum="943014D25B912A66" modified="2022-01-19" version="1">MGRKKKKPMKPWCWYCNREFEDEKILIQHQKAKHFKCHICHKKLYTGPGLAIHCMQVHKENIDKVPNAIPGRYDIEVEIYGMEGIPEKDLLAHAAKTNQKEKGDAEDEPTKPKQSAQSTSQNIPPPPMMPGMMPGHMPGQMPGQMPGPMPGQMPGPMPGQMPGMMPGQMRGPMPPGMPPMPPMPPRMPGMPEMPGMPPFMPGMPMPPMPPGFRPPMGGPGGMMPPRGLPGMPPVSLEAPASSTSSNQPATAAQAGPSLGPMGGGQHQQPPKPLFPSAAAATTASVTGPGNSTSASTIGPVKPTFPAYANPAPEPAKSMPIPSPNTATVTAAAPKLNTPASTMAAEKTPSSGKGMTTGTSKIVHPDDELSLEEFRANLPKYKKTIAPSASSVPVSAPAMPPRPPHIMPGVSSMPQPPIRPQGGMTMPPQPPNPPMGMMPTPPGGLMQGMPPMGQMPQMPPRMGGMPNQQGGMFGGQPMIPGMSPMTSAGPQHPSMQQGPRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJE3</accession>
    <name>A0A8B7YJE3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Stabilizer of axonemal microtubules 2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM154 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091696.1">
        <property type="nucleotide sequence ID" value="XM_022236004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJE3"/>
    <dbReference type="GeneID" id="110979875"/>
    <dbReference type="KEGG" id="aplc:110979875"/>
    <dbReference type="OMA" id="THMADYT"/>
    <dbReference type="OrthoDB" id="365640at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033336">
        <property type="entry name" value="SAXO1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31516:SF17">
        <property type="entry name" value="STABILIZER OF AXONEMAL MICROTUBULES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022091696.1"/>
        </source>
    </evidence>
    <sequence length="491" mass="55501" checksum="C4BFE16233BA2337" modified="2022-01-19" version="1">MTVTQMNRKVRTLNKDISNIRARQIQTQVKLSEYQEAYVAWPWQPRRESMRPVAKKPVPTSRPKLKTTNQCTFVAHKTTQRPKATLNRKGYHAPSAKMLTETTYDTDFTEKTASRPAACKPKEAALSTPSPFDSKTVYEKTYTAWTPEQTKECKVQVKVVEDNLKSGNPGKKFQTTTTVKEDYIDHGNVSPAKSTKPAEKPIQPTARFADETTHRADFTPKAPPSVEVFKPKEEYKFNSAPFDDLTIFRRDFPEHRGVKKEQSYKPKNDYSPSASEFDDRTTQRMAYQAWPIPKREHLPWAERQGYIPNRGKLQLVTSYQSDFEDPSYLMPKALFKCRATPYKYDNNLGAGESGPFDDRTEYRSTFIAWDGVKRPASYKIIEKYKYPETPFSGESTFTSHFKGVRGPPAKSCRPATRPHSSSAGMISFDTTYRATFDTAAAKSQDRPKSCPTQRCSTDSEAAEDEKGEGPSGEGDVGTKDGASEGTQIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKJ5</accession>
    <name>A0A8B7YKJ5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Ankyrin repeat domain-containing protein 11-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7 8 9 10 11" type="primary">LOC110980060</name>
    </gene>
    <organism evidence="3 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092053.1">
        <property type="nucleotide sequence ID" value="XM_022236361.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092054.1">
        <property type="nucleotide sequence ID" value="XM_022236362.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092055.1">
        <property type="nucleotide sequence ID" value="XM_022236363.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092056.1">
        <property type="nucleotide sequence ID" value="XM_022236364.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092057.1">
        <property type="nucleotide sequence ID" value="XM_022236365.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092058.1">
        <property type="nucleotide sequence ID" value="XM_022236366.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092059.1">
        <property type="nucleotide sequence ID" value="XM_022236367.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092061.1">
        <property type="nucleotide sequence ID" value="XM_022236369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKJ5"/>
    <dbReference type="GeneID" id="110980060"/>
    <dbReference type="KEGG" id="aplc:110980060"/>
    <dbReference type="OMA" id="DANFRME"/>
    <dbReference type="OrthoDB" id="5806726at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="166"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="567"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="612"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="889"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="935"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="966"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022092053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022092054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022092055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022092057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022092058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022092059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022092061.1"/>
        </source>
    </evidence>
    <sequence length="1251" mass="137875" checksum="36E687BAAADC1293" modified="2022-01-19" version="1">MVQYSGMADKTSPHRKEKQGGVKSPMATKGDGGKTLKRKLFTGINGEGAEDKKPPKPTPKRKKPTSQPGSPTLLGTPGRSIPLSERQQLALLMQMTANEENNSPVINHPAPKPIMTPGAVGGVKNKANKRNERGEAPLHLACIRGDVQATKNLIKQGAEVNVQDFAGWTPLHEACNHGYYEIVKLLLKAGAFVNTQGLEDDTPLHDAAVNGHVKVVDLLLKHGANPLQVNKRGKAPIDLACNAEIRSLMKNEIIETSSDTSLAEARPPTSPESVDSVEDHDLRNGDARPDPYEFDHQDQSPNEQKITIHWASPDKSGKGTIMEITRTIPKLNDRATPNSMTSTTTSDSDLFDPLLNSKSLNNSAANITMVKQQQQQHLPQQQQQQQQPVRVVVTECRNSHQELKSPTEVCNNTSRSSPKESNTVPMCDMGVPRVAGAKEDSDSSLSDLNLLMSDDSNAGTETKGNSSKADSTTAESNPSSFIWNTSNGRTLPQSNFVSNAMVPTIDSSAQQHVNTGSISGSIFPENSSNKQDTSLVNLNLNSKASSSMNSLASFSTSSLSLLPGMSVQQAQTHKAPDTASESVDSQQHTQMVSSNVVGQDSPVQSSQSTHQSRSLPATSATLTSTNHETEQPVDRPVPGCAETQANNVSEWRTDTKPVMPVADSRLESESDSSVDRLLQPQAQQQQPQQQQHERRDRPKRHKERSHQKSHRRHHRHQSQSSQGSRSSKDERHFSEEASTSSKSPSPEVKSVENGRMELGENSPDGHKSDPQQKPSPFPVAREYYIVSQPSSADNAGEIKALLLRPRDPSTVSQTRPKEATTSPTSVSSTSASLPSETNQKPVEQDPTTSSGNTDSVAASSSTDTTNRKSPVLRDLERRRSPARGSPDVTSSVSTSNHTSQSGKGSPKTQEQPAVPEKAQPPKPTRTLRSNSGMVNSNTNHNNSETNSNEKEVVITTPMTRSRRMQAAESASSTSTPEPSLESSHPRKRKIARHRQQQQTNGECSSNMEDRRQTPPAPMERVNAMEMFLNIRQRIEARQRRMIANVQPKQPTGYSEYLMLRKTYLLASDPDTKINVAIPNMEAPPELHSDSVKQFIEQEKKRHDLRCRHCIEREKLMLAAEQDIIRVYARAARASANQSTPFSVCTVLKNQEVYNMPDPVPHEDNKGSIRQRYNGRQLLSWLQDVDDKYEKIKEDLLQRHQHEAASLYAIQKLEWELKLQELKLWDPKNPPQVPSCHVPMVEVDRDLDLLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YLX5</accession>
    <name>A0A8B7YLX5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Low-density lipoprotein receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110981210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094269.1">
        <property type="nucleotide sequence ID" value="XM_022238577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YLX5"/>
    <dbReference type="GeneID" id="110981210"/>
    <dbReference type="KEGG" id="aplc:110981210"/>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053103">
        <property type="entry name" value="IDLSRF-like_peptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20967:SF0">
        <property type="entry name" value="PROHORMONE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034428179" evidence="3">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022094269.1"/>
        </source>
    </evidence>
    <sequence length="149" mass="16405" checksum="C5588D83D38D3F10" modified="2022-01-19" version="1">MQATRFVFVLFGTFLTGLCASHPEDEGNLMQSKGTTCGFGQMKCFFSDECFAIDGLCDGKVDCVNGDDEDPIGTCGALGPIWPVLCPVPGQWKCIFSHECLDYSKVCDGKKDCARGDDELYYGCDYRKRAPDQMPGEFVLKVPDGEREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPE1</accession>
    <name>A0A8B7YPE1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Large neutral amino acids transporter small subunit 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110981337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094537.1">
        <property type="nucleotide sequence ID" value="XM_022238845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPE1"/>
    <dbReference type="GeneID" id="110981337"/>
    <dbReference type="KEGG" id="aplc:110981337"/>
    <dbReference type="OMA" id="FTWETIL"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000003">
        <property type="entry name" value="Y+L amino acid transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF528">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN JHI-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022094537.1"/>
        </source>
    </evidence>
    <sequence length="504" mass="54455" checksum="D2002B483CB08ED7" modified="2022-01-19" version="1">MASEGGDAVKTDFAPSSPAPKDGTANGQPVGDSNLVRLKPKISLLNGVTIIVGIIIGSGIFISPQIVLGFTKSVGLSLMVWAACGVFSMIGALCYGELGTMITMSGGDYAYILTAFGDLPAFLLLWVTLVIIRPTAQAVVAMTFANYILQPFFTVDDPNCGPPSSAVKLLACCCVLVLTFVNCISVKAATRVQDVFTAAKVIALIIIIIAGLVQLFRGETENLENAFEGSSSNVFDIVLALYSGLFAYGGWNYLNFVTEELVNPYKNLPRAIVISVPLVIVVYVMANVAYFTAISTPELAASKAVAVTFGSKLFGVMAWIMPVSVALSTFGGVNGLLLTGSRIYFVGARNGHLPEALAMISVRWKTPMPSLIFTCCLTLLYMPAKNIIQLINYFSFVTWLATGTAIAGQLFLRWTRPEMARPVKVPLALPIIFFFMCLFLVVMGFVAAPFDCLIGSAIICTGFPIYFFGVYWTNKPEWLVNCIHDVTHQMQKMLVCVAEEKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPZ3</accession>
    <name>A0A8B7YPZ3_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-1,4-galactosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110981330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyses the transfer of galactose onto proteins or lipids.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022094520.1">
        <property type="nucleotide sequence ID" value="XM_022238828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPZ3"/>
    <dbReference type="GeneID" id="110981330"/>
    <dbReference type="KEGG" id="aplc:110981330"/>
    <dbReference type="OMA" id="IPMHELE"/>
    <dbReference type="OrthoDB" id="10016069at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008489">
        <property type="term" value="F:UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF38">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="228"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="12">
        <location>
            <begin position="341"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022094520.1"/>
        </source>
    </evidence>
    <sequence length="476" mass="53597" checksum="C9905B5602A33194" modified="2022-01-19" version="1">MFPPRRVLRSIRWLLASVVLVVLILLSGLLFFGNGSRPAPVSVINRKHDDHSLIIQVTESPNGPANPVSNKSDLRPIIGSKSSIFGPANPVSSESDLRPVVGSTELSIGPAIPVSNRNDRRPVIGSKMSLHVHEAALEHTIKKPLSECPKLENIPGLVEDRPMNLMSGLPMDELERFFFPGHPELIREIVSISNHDLPGLRGAGVHTPEGSSSAGSVHLIDGLSPRAVQNGDYRYLPGGHWRPADCIPRWKVAIVVPYRNRTIQLSLFLRYMIPFLQKQRLEFAIYIVNQANNNAFNRGMLLNVGYLEALKFTQWDCFIFHDVDHLPQSEFNYYGCVDLPRHFISGADNRNYRVPYSTSFGGVNGFTTAQFRQINGLGNVYQGWCCEDDDLELRTRMAGLKKPRRLGKVGYYKAISLNHDKIKTRLGELEKANRQFLRKAQSRFKTDGLNNLMYKLPQLELHTLYTNISVDIQPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQD1</accession>
    <name>A0A8B7YQD1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Histone H1, early embryonic-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110981833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095484.1">
        <property type="nucleotide sequence ID" value="XM_022239792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQD1"/>
    <dbReference type="GeneID" id="110981833"/>
    <dbReference type="KEGG" id="aplc:110981833"/>
    <dbReference type="OMA" id="ANYDSHI"/>
    <dbReference type="OrthoDB" id="7790887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000140">
        <property type="entry name" value="Histone H1.0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="8">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022095484.1"/>
        </source>
    </evidence>
    <sequence length="221" mass="23908" checksum="2A6111F9ABA62BF1" modified="2022-01-19" version="1">MAEQTAVAAKPLKPKKKAAPKKKATHPSAGEMILSAVTNLKDQPRSGSSLQAIKKYVHANYNLPANYDSHIKRGIKTLVKSGKLTQTKGKGASGSFKLDNKAAKASASQKAKKEKQRQRAKALKEKKKEQAKARREKKAAKKAAQKEKLKEKKKSKSPKKKADKKKSPKKTKKPAAKKPAAKKPAAKKPAPKKPAAKKSKVKTGKSPKKAAKKTGKKAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YQP3</accession>
    <name>A0A8B7YQP3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110981487</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110981487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094780.1">
        <property type="nucleotide sequence ID" value="XM_022239088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YQP3"/>
    <dbReference type="GeneID" id="110981487"/>
    <dbReference type="KEGG" id="aplc:110981487"/>
    <dbReference type="OMA" id="GMFESAT"/>
    <dbReference type="OrthoDB" id="416710at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48312:SF1">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19798">
        <property type="entry name" value="Sulfotransfer_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022094780.1"/>
        </source>
    </evidence>
    <sequence length="297" mass="33831" checksum="0088EBEBD1F63494" modified="2022-01-19" version="1">MADDLQRVFLWGLSRSMSTALLKCLSYADGIQIVNQPYASAFYDGPEAVRPEPNPNDKLLTQIVVECDKIARESETAEVEGIASSLMTMEWIRDNLLQASYPDRKLLLCRDQAHYLNGRYDMLPHGFKYSFLIRHPYKVFRSLRKLLTDTWGDFPDMRSLPSLAFPPGGGFKELFELVQYVKENFDPRPTIIDADDLLQDPAGILSIYCARMGIPYTSKLLSWKAGHEITSTWLMSKGVSVANKCQGFYRRAFESERFGKPTPMPDPASLPEDVRACAEMSMEYYESLHRERVIASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YRP6</accession>
    <name>A0A8B7YRP6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28 29" type="primary">LOC110981671</name>
    </gene>
    <organism evidence="27 29">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095133.1">
        <property type="nucleotide sequence ID" value="XM_022239441.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095135.1">
        <property type="nucleotide sequence ID" value="XM_022239443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YRP6"/>
    <dbReference type="GeneID" id="110981671"/>
    <dbReference type="KEGG" id="aplc:110981671"/>
    <dbReference type="CTD" id="64747"/>
    <dbReference type="OMA" id="CVLYYSA"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17340">
        <property type="entry name" value="MFS_MFSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="26">
        <location>
            <begin position="59"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022095133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="RefSeq" id="XP_022095135.1"/>
        </source>
    </evidence>
    <sequence length="492" mass="54659" checksum="C43BE3ECCBE082AD" modified="2022-01-19" version="1">MAENSGYDSDVEGINEKSPLLSSGVPRGVNGDYDVEYAGQLTGCGAWRICDPRSLWHRYTFILVLTCLLSFGSYYCYDTPAALEEQIKEDLQIDTSAYVLLYSLYSWPNVVLCFFGGFLIDRVFGIRIGTLVFGGFVLVGQLIFSLGALFDNWICMVAGRFVFGLGGENLAVAQNTYAVTWFKEKELNMVFGLQLSFSRIGSTLNMNVNKPIYDSINPDLVGYKRLGYTLLVGVAMCVFSVICGIIIGILDYRAEKILNRKQAGTGEVIKIRDVKDFPASLWLIFLICVFYYVTVFPFIGIGVVFFSEKYGLVPAEANIVNSLVYFISAGASPVFGFVVDKTGRNIFWVILGTIITLGCHLTLAFTFITPFLVMSIMGLAYSILACALWPLVAFIMPEHQLGTSYGFMQSIQNLGLAVVTIIIGVIVDGSGYLILEVFMCAMLCVAIIFCVLLYLIDTSRRLGLNLSAKERKQIKEAKQREREMQSECEKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YSM0</accession>
    <name>A0A8B7YSM0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import receptor subunit TOM22 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110981821</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095460.1">
        <property type="nucleotide sequence ID" value="XM_022239768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YSM0"/>
    <dbReference type="GeneID" id="110981821"/>
    <dbReference type="KEGG" id="aplc:110981821"/>
    <dbReference type="OMA" id="DKDSGME"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022095460.1"/>
        </source>
    </evidence>
    <sequence length="126" mass="13564" checksum="B056510706446DD8" modified="2022-01-19" version="1">MAESGKSSKAVTFVDDDDFEDETLAERLYGLTEMFPESVRNGASALTSASLKGVKLSYNFSRSALWILSTSFMVLMLPVIFETEIAQMEQAQLQKQRQILLGPNAAMSGAGGLPGGMTPPIAAMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YT09</accession>
    <name>A0A8B7YT09_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein LOC110981313</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110981313</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022094491.1">
        <property type="nucleotide sequence ID" value="XM_022238799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YT09"/>
    <dbReference type="GeneID" id="110981313"/>
    <dbReference type="KEGG" id="aplc:110981313"/>
    <dbReference type="OrthoDB" id="5512589at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF314">
        <property type="entry name" value="HEXOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022094491.1"/>
        </source>
    </evidence>
    <sequence length="838" mass="91949" checksum="071C154E64A76738" modified="2022-01-19" version="1">MHFCGQGIMCTKFKVFLLTMVFSVSSTLFFVYIFERSDRAPYSLHDLLKKSQRSMTGRFQLAAKGTVDAAAMHRLISSFYSNADQNRTEVVNSSASSKGGGKKKLQAGNWKVTDSSGSKSVNESIQEDVGPPSSQERINKSGADTEMKFDLGKSKESSVPGKEVDSGRVEGTTDLKQLTKDSNQTNKATSSPDSKLPLGNKSWTGGNQKLKASNKPDSKTPELQIHRDGDKNGSEGKLVLNKSVASSMKWEKNNTAGVHLTHHSTNGIVNGQIRPAQGKNAGSGKWAGEKKQDGGFKKETPKEVLSSDKTNPLKTRKDASKVVDFQRRWDANKGDGRKPKTAQKTNQKPLWANGKETNNAAQFSGVKKAPEDKWKKEHNMNVEAKNRGDPIKVAPVPQQGKKSNDNSGKPTIDQKQVTQNHWKPPPMQEWKKPGPAKLSGQLPKTVKGNENQRAKPAPPLKQGAKAGIDTSVARNERDKQVRGNWNKAGDKNAVQDRKLKQEAPKSSGYVNGSENSSPPKISNSGNKVPGSGPLLAVGGNTKLVSKNDPVNGAGNPMMTHDFGLVLNEPLACKKADGSNKAVFLLVLVVTTHGNSDARQTIRETWASPGDVMGKAIVTLFMLGQSINRTLNELLKSESDKYHDILVEDFIDSYRNLTLKTMMGLKWMGEYCPQASYVMKTDDDMYINRENLLSLLTSPATPTKRFVTGHVFGGMPPIRISTQKNYMPVEIYGEPKYPPYCAGAAYVMSGDVPTLVFNVATLIPKYVHIEDVLVGICLRKLGIKPIQNNGFRHNAMPFVPYSFCNYQNVITMHGATIQNMLSIWNGQKADRQSKQNKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YT89</accession>
    <name>A0A8B7YT89_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="3 8">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110981370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3 8"/>
    <dbReference type="RefSeq" id="XP_022094576.1">
        <property type="nucleotide sequence ID" value="XM_022238884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YT89"/>
    <dbReference type="GeneID" id="110981370"/>
    <dbReference type="KEGG" id="aplc:110981370"/>
    <dbReference type="OMA" id="INPHWKV"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF141">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="9">
        <location>
            <begin position="2"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022094576.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="29275" checksum="D3E97B362C0DB4FA" modified="2022-01-19" version="1">MAQWGYTGDKGPDHWCEKFPDAKGKRQSPIDIVTTDTKVDASLGPLNIDYSSARCTEIFNNGFTFQVNAESGGTNLSGGPLSNNHRLAQFHCHWGSKDGQGSEHTVNGAPYDAELHLVHWNSDLFQSVGDALPKDKGLAVLTAFLKVGKENAGWSKLVALLNKVKCKDDKCCLEAGFDPTVLLPENKKDYWTYEGSLTTPPCYESARFIIYREPVEISAQQIKTLRDLLSYKQGGQAECGCPEHLGDNYRPTMPLNGRVVTASFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YU47</accession>
    <name>A0A8B7YU47_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110982596 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096824.1">
        <property type="nucleotide sequence ID" value="XM_022241132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YU47"/>
    <dbReference type="GeneID" id="110982596"/>
    <dbReference type="KEGG" id="aplc:110982596"/>
    <dbReference type="OrthoDB" id="10148734at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096824.1"/>
        </source>
    </evidence>
    <sequence length="337" mass="37498" checksum="38E454A2D72A3457" modified="2022-01-19" version="1">MGCAATKPDDDASNDPQSAQQKMERQEGRSGTKVLEEEIRLENPSGSGDAVPFQAWIADTVWPYVLTNVTANGLASKAGLRRGDQLIGINGLKIQKYSLQHVLYLLCKDIETKLLLELKRTDNGTTKYVWSFFELSIRDGNPVIQVIQLLETDIDAIPTEILEAAVSWIGAPVNAFDIYLPDENLYLGIDGDKLSFMQYDRDKCTFYRYNYEGGDSSQGNVVAYTQQNFKPPPTDIKNTPATTNGTSAPELFVEDFPSSMVTQLSFPPDPRLWYEKLDTTGDPIGRTLQSMTQQGWYLARDPENNAAILSQEAILVNVLPQELDRIPRKTTGEASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YU75</accession>
    <name>A0A8B7YU75_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Neuronal acetylcholine receptor subunit beta-4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110982264</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096252.1">
        <property type="nucleotide sequence ID" value="XM_022240560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YU75"/>
    <dbReference type="GeneID" id="110982264"/>
    <dbReference type="KEGG" id="aplc:110982264"/>
    <dbReference type="OMA" id="NARTHEM"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18997">
        <property type="entry name" value="LGIC_ECD_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000005">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 15" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034650859" evidence="15">
        <location>
            <begin position="36"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="16">
        <location>
            <begin position="41"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="17">
        <location>
            <begin position="254"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022096252.1"/>
        </source>
    </evidence>
    <sequence length="533" mass="62269" checksum="768B593A586D1C2B" modified="2022-01-19" version="1">MCRLRETARDLWRIVQRTWCCWLLLASLHLSECFASEAADKLFYKLTHENNYNPMIRPVVNESDTVVVKFGLSVSQLIDIDEKNQIMTTSVWVKHTWKDYQLTWDPDEYDGIRYLHIPSGLLWLPDILLYNNADGYYDVRFLVNAIVHYDGTVRWLPPAIYKSSCEINIEFFPFDEQNCTMKFGPWTHESRKVDMVMEQDIVDQEDYTENGEWQIVESPGLRHHIDYPCCDYKFADVTFYFLLHRKPLFYIVTLVIPCILISFLTTLVFYLPADAQEKITLSISILLALIVFLLLIPSIIPPTSTTLPLIGRYMLFTMVLVTMSITATVIVINIHFRSARTHTMPTWVRTVFLYYLPKMLNISRPGGLELPSGKKYKSMKKHTNYTPASYNAPLRGKYFYDRKFMRSGAKYMVNTITPSLLEEIQFRDRQYSDASDSRPLSKECAELIDHVETIAKYFQMEDEHYKGAEDWKFVAMVVDRVFLWIFAIMCLCGSLGIILRSPVFWEGPNFHQPSNYTKPILLNETIYGRPDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUH4</accession>
    <name>A0A8B7YUH4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipid scramblase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110982671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phospholipid scramblase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096954.1">
        <property type="nucleotide sequence ID" value="XM_022241262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUH4"/>
    <dbReference type="GeneID" id="110982671"/>
    <dbReference type="KEGG" id="aplc:110982671"/>
    <dbReference type="OMA" id="WCANADC"/>
    <dbReference type="OrthoDB" id="191150at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005552">
        <property type="entry name" value="Scramblase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248:SF63">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23248">
        <property type="entry name" value="PHOSPHOLIPID SCRAMBLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03803">
        <property type="entry name" value="Scramblase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022096954.1"/>
        </source>
    </evidence>
    <sequence length="306" mass="33874" checksum="EF08D1E55028B591" modified="2022-01-19" version="1">MASDVKYQTFGAGTVPDGGPAAGILAPPAAGAQQGYISPQQPQIQASGMQPVVAPSGAPAPLGQIQWMPHPQAVPGCPPGLEYLTQVDQLLVHQQVELFEVVTDIETQNRYQVKNSLGQQIYFAHEESEFCERICCGPRRGFTMHVTDNMNQEVLRISRELKICGGCCWCANADCCAMDIAVEAPVGNVIGYVRQAQSWWYPNFDLLNVAKEPVLKILGPFWFCQNVCCTGDIDFNVMNEDSNIEVGKLSKQWGGFVKEAFTKADNFNVNFPLDLSVDMKACLLGAVFLIDFMYFERKKDTNERHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUX8</accession>
    <name>A0A8B7YUX8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">THAP domain-containing protein 4-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110981667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:63117"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="RefSeq" id="XP_022095131.1">
        <property type="nucleotide sequence ID" value="XM_022239439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUX8"/>
    <dbReference type="GeneID" id="110981667"/>
    <dbReference type="KEGG" id="aplc:110981667"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF4">
        <property type="entry name" value="PEROXYNITRITE ISOMERASE THAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4-like heme-binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00036993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022095131.1"/>
        </source>
    </evidence>
    <sequence length="195" mass="21988" checksum="42466D55DE0A29BA" modified="2022-01-19" version="1">MRQGSKTVTKKRMIAKSLRDETYLREILGFPAVADMAKLHEGAQPLAWLLGQWESIEAKGMFPTSSSFNYTETLNITHLGQPVLNFYSETWMEGVPKHIESGFLRMNPGTTRVAYMCAQNAGIVEIEEGELDGTSVELTEPSLLRMTFAKEEGATGLKRTFRLKSDGHLEQIVFMTTPKTPFSKHLHVTYKKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUY5</accession>
    <name>A0A8B7YUY5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MAM and LDL-receptor class A domain-containing protein 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110982428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096502.1">
        <property type="nucleotide sequence ID" value="XM_022240810.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110982428"/>
    <dbReference type="KEGG" id="aplc:110982428"/>
    <dbReference type="OMA" id="AYVILEC"/>
    <dbReference type="OrthoDB" id="412155at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051560">
        <property type="entry name" value="MAM_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282">
        <property type="entry name" value="APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23282:SF101">
        <property type="entry name" value="MAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="15"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="193"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="358"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="547"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="721"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="888"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022096502.1"/>
        </source>
    </evidence>
    <sequence length="1457" mass="159159" checksum="9391342701789E8B" modified="2022-01-19" version="1">MCSVKASQASSQNTFNCAFESGFCGWAQATDDDGDFDRNQGSTPTWNTGPSSDHTTGTGYYAYMEGTGKGWNNKLRLVSPDVTVVPSSGVKCVRFWYHIYGVLSGSLYVYTSSDGTAGNLGSAIFQRIGSQGDQWLEAGLDVTSSVSPFKVVFEAQRGLLDTSDIALDDVELLDGYCSQVVITPTSSTIPSLRECDFEDPSICGFTQDTNDNFNWQRKNGQASSGTTGPKTDHTTETTAGYYMYIDSQSRQVGDLARLSSPFFPSTNGECLEIYFYMYGANVGTLNIYLVEKGGDPTKQIPDWTRTGNQDDRWLMARMAAFTTLDYQVVLEATVGGTSLAVIAIDDLRIVSGSCQMHGDCSFESNSLCGWIQDTIDQIDWLLKTGAKGSGPKSDHTMEDNTGWYIYLDAASAQIGNEAYLSWFENGVADPTTVRCLTFWYYMSGANTGTLAIKREDVTTDVKWELSGEQGSSWNFGQITIQQSFSLIIIIAGKVTSTLSSGNDIAVDDIILTDNFCPTMPPGAGVGTPVTPSPATTNPPVVIPPGPANCDFEAGTFCSFTSDSTADFNWVLRQGPASTSGHTGPKYDHTKRDATGYYALADASGNLDKKARLMSGDVPSPGGSDNCLTFWYYMYGDRVANLNVYLQQQGSGLGKPFWMRTASQGEHWIMASVELAKLTNTYKVVFEGVTGKGSGSDIAIDDIMVASNACPIPTKTPGGHPLSCDFEQGFVPCGWSQEDSTSGNDNFDWGLGSGNTVTFGTGPAFDHTLGTGSGTYLYINASPQKDGDKAWIKTGTYPPAQGHCLEFYYHMRGIHIGRLNVFLKENDKYSHYYFTINGNLGEIWNVGRFPFVAYSDYQVVFEATVGNGDQGDIAIDDVEIFSGTCPPIDSCNFDDASSCTWVNDLTTDTFDWIDGAGGTPSFNTGPSVDHTYGTAQGLYKYIEASYPKKKGDFAIFKSQALPSTTSSGRCLTFWYHMYGNDIGELQVISENPADGLTTTFWKLGGQNLGDFWLEGQMPVSNPNPYKMQFKGVIGASYEGDIALDDIEFKDTLCGVYPSNADTGATLPTHPPPPTTVWPATYDCDFEQDMCSYTDATDDDFDWRRLSGATGSSQTGPSVDHTLGTSAGYYIYIEVSFQSSGDKARLESPIITASTTPKCLTFWYHMYGDHINQLNVYTRDAGSTALGPAKWTRKGTRDDQWYVGDMMGTSTAGYQIIFEGIAGNSYRGDIALDDITVTNGLCPVRDLCEFEDTHLCQYSQETANDDFDWTQNSGPTPTANTGPKVDHTYQTAAGKYMYAQAQGHISQKAQLISPEYKIQTGINTHCFTFNYHMFGDQMGTLNIKSKTFNTEKLVWSQQGNNGDQWYEDYFEVSEVLAFRLIFEAVIGSGPRSDIAIDDISHSIGSCPKNTMCDFESGQCDWTNDQGDDFDWVTLKGSTYSSYTGPSIDHTHGTKDGKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YVD9</accession>
    <name>A0A8B7YVD9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110982389</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110982389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096450.1">
        <property type="nucleotide sequence ID" value="XM_022240758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YVD9"/>
    <dbReference type="GeneID" id="110982389"/>
    <dbReference type="KEGG" id="aplc:110982389"/>
    <dbReference type="OMA" id="GCKTYDG"/>
    <dbReference type="OrthoDB" id="10306945at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050975">
        <property type="entry name" value="Sleep_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33562">
        <property type="entry name" value="ATILLA, ISOFORM B-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034482109" evidence="3">
        <location>
            <begin position="20"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022096450.1"/>
        </source>
    </evidence>
    <sequence length="130" mass="14081" checksum="9B2C4F40F3C12837" modified="2022-01-19" version="1">MNAALTLVAFASALTCCAAIRCYECTVTSVGAGDSKCADPFYKPEPPYLRDCDSEIYKKCSKTKTYLANDKISIVRSCAEQDCVDKGCKTYDGQTVCHHCCYGDMCNGAGVLTFDFIVAVITVGLTFLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXU9</accession>
    <name>A0A8B7YXU9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DDB1- and CUL4-associated factor 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">WD repeat-containing protein 68</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">WD repeat-containing protein An11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110982984</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat DCAF7 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097507.1">
        <property type="nucleotide sequence ID" value="XM_022241815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YXU9"/>
    <dbReference type="GeneID" id="110982984"/>
    <dbReference type="KEGG" id="aplc:110982984"/>
    <dbReference type="CTD" id="10238"/>
    <dbReference type="OMA" id="TIAMDAC"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000049">
        <property type="entry name" value="DDB1-and CUL4-associated factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022097507.1"/>
        </source>
    </evidence>
    <sequence length="343" mass="39086" checksum="5BFBA6C5CFE269DF" modified="2022-01-19" version="1">MASLPPKRKEIYKYEAPWTLYSMNWSVRPDKRFRLAVGSFVEEYNNKVQIVSLNEETSEFEARSTFDHPYPTTKIMWIPDSKGVFQDLVATSGDYLRVWRVSDTDTRLECLLNNNKNSDFCAPLTSFDWNEVDPNLLGTSSIDTTCTIWGLETGQMLGRVNMVTGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPQHHPLLRLAWNKQDPNYLATMAMDSFEVIILDVRVPCTPVARLNNHRACVNGIAWAPHSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTADGEINHIQWASTQPDWIAICYNNCMEILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYP6</accession>
    <name>A0A8B7YYP6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110983482</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110983482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098458.1">
        <property type="nucleotide sequence ID" value="XM_022242766.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983482"/>
    <dbReference type="KEGG" id="aplc:110983482"/>
    <dbReference type="OMA" id="FRMFAFT"/>
    <dbReference type="OrthoDB" id="6234674at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
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        <property type="entry name" value="palladin isoform X1"/>
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        <property type="match status" value="7"/>
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        <property type="entry name" value="Ig_V-set"/>
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        <property type="entry name" value="Neural/epithelial_adhesion"/>
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        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN TURTLE HOMOLOG B"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
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    <feature type="chain" id="PRO_5034531101" evidence="7">
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            <begin position="31"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YYT8</accession>
    <name>A0A8B7YYT8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histone acetyltransferase</fullName>
            <ecNumber evidence="19">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">LOC110983512</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="19"/>
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        <property type="nucleotide sequence ID" value="XM_022242816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YYT8"/>
    <dbReference type="GeneID" id="110983512"/>
    <dbReference type="KEGG" id="aplc:110983512"/>
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    <dbReference type="OMA" id="EIGRYEM"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036409">
        <property type="term" value="C:histone H3-K14 acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902035">
        <property type="term" value="P:positive regulation of hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myelin transcription factor 1-like, a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002515">
        <property type="entry name" value="Znf_C2H2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036060">
        <property type="entry name" value="Znf_C2H2C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01530">
        <property type="entry name" value="zf-C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103637">
        <property type="entry name" value="CCHHC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51802">
        <property type="entry name" value="ZF_CCHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="17" id="KW-0137">Centromere</keyword>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="21">
        <location>
            <begin position="318"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="18">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022098508.1"/>
        </source>
    </evidence>
    <sequence length="598" mass="68904" checksum="5609595218BC812E" modified="2022-01-19" version="1">MRRRKPRQDSSSGSEFVSEEESESSGEIDLSSTDEESGNRRVTRTSTRMQTRATNQALLVQPLRRSPLKGRKRGSSGSNSAESSDTDSNTKTPVKRKRGHPLANSGTSDAESNESTGPTHSPKKRAKTDDVNLSRSPGKPGVVLNAEFETRQRKSKLIAVAQVQRSLDIMELKCPVPGCDSLGHITGKFTKHRTVSGCPIYHNMTLAECKARAETRADKARQKAEEEGEEQDLAGKNLRQSSESRFKQQKKYQVLELRRQRKELSAEQREKNRNHREEFHKSREPLLDGLTSQYDMDLFRQAQIRASEEMEREYNNMPYDGVLKKIDFGRFELGTWYSSPYPEEYARLPKLYICEFCLKYMKSSTILRRHTAKCVWRHPPGDEIYRKHNISFFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYIMTLNDPTGCHIVGYFSKEKNSFLNYNVSCILTLPQFMRQGYGKMIIDFSYLLSKREEKIGSPEKPLSDLGLISYRSYWKDVVLKYLSKYDGREISIKDISQETAINPYDIVSTLQSLSMLKYWKGKHLVLKRQDLIDQYLSKAAKKNSLKTIDPVYLKWTPPVGDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ35</accession>
    <name>A0A8B7YZ35_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110983573</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022098614.1">
        <property type="nucleotide sequence ID" value="XM_022242922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZ35"/>
    <dbReference type="GeneID" id="110983573"/>
    <dbReference type="KEGG" id="aplc:110983573"/>
    <dbReference type="OMA" id="FWFTCAN"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF79">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022098614.1"/>
        </source>
    </evidence>
    <sequence length="353" mass="40458" checksum="656A082C83A5A6F7" modified="2022-01-19" version="1">MDTALMVEYSKEMKKLRSRVDLASTTFQVNFLESWTRLLEALSCLHYITTFIFVGHVSLAILIYLLFTDLYWISLIYFTWLAYDWNTPCRGARRWMWVRQWKIWKRGRDYFPVNLVKTAELDPSKNYLLGYHPHGVLVFGGFFNFATDATGLSTVFPGMKVFLMTLHQMFKMPIFRDYFMLSGSVSVRKDSIEWVLSQNGVGNVSVVVVGGAPEALDAHPGMHRLSIKARKGFVKLALVHGADLVPAYTFGENNAYDQVDNAPGTRLRRFQNIMTKICGFSPPLFYGRGFSLLPYRTPITTIVGRPIAVKQTPNPTRDQVESMHALYIKELTELFETHKSKYGVLPDQHLEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ39</accession>
    <name>A0A8B7YZ39_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytoplasmic protein NCK2-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110983577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022098619.1">
        <property type="nucleotide sequence ID" value="XM_022242927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YZ39"/>
    <dbReference type="GeneID" id="110983577"/>
    <dbReference type="KEGG" id="aplc:110983577"/>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048013">
        <property type="term" value="P:ephrin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11766">
        <property type="entry name" value="SH3_Nck_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11767">
        <property type="entry name" value="SH3_Nck_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000061">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000110">
        <property type="entry name" value="Cytoplasmic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051184">
        <property type="entry name" value="Tyrosine-phos_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969:SF14">
        <property type="entry name" value="DREADLOCKS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19969">
        <property type="entry name" value="SH2-SH3 ADAPTOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="137"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="218"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="6">
        <location>
            <begin position="312"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022098619.1"/>
        </source>
    </evidence>
    <sequence length="421" mass="47926" checksum="A082039AC0FADD15" modified="2022-01-19" version="1">MPVSTTRQIAAVPYIPCSGATSTFQWKKFKVMSDEEIVYVIAKWDYTANQQEELNIRKNERLTLIDDTKSWWKVRKASGDSGYVPSNFVKKEKKSFMNKLRDKIVPSRDTKQPGMGPLPHATEHGQRDLAESAEFDQLCVPAKVLYNYVARQPDELSLRKGEKLTVLEKSGDGWWRGECNGETGWFPSNYVNEEGDSLPASQKSSVSSKGDENVLGEDYIHTVIALYKFQGRNDEELNFEQGERLDILQRPEDDPEWWKARNTKGEIGLVPKNYVEEITANAQHVPVSNPVISNDVGVAQAENGNSLKHKIWFCGTLKRDESERTLMELNCEDGTFLIRESETTPGGYSVSVKAPDKIKHFKVQRVDDQYCIGSKRFESLDYLIEHYKKAPIFSCGKTNFKLYLTKPYREVCNNGGAHYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z5Y9</accession>
    <name>A0A8B7Z5Y9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate sulfotransferase 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100215.1">
        <property type="nucleotide sequence ID" value="XM_022244523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z5Y9"/>
    <dbReference type="GeneID" id="110984379"/>
    <dbReference type="KEGG" id="aplc:110984379"/>
    <dbReference type="OMA" id="FANNRDV"/>
    <dbReference type="OrthoDB" id="6138663at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001517">
        <property type="term" value="F:N-acetylglucosamine 6-O-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051135">
        <property type="entry name" value="Gal/GlcNAc/GalNAc_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704">
        <property type="entry name" value="CARBOHYDRATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10704:SF44">
        <property type="entry name" value="LD35051P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="1">
        <location>
            <begin position="133"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100215.1"/>
        </source>
    </evidence>
    <sequence length="320" mass="37084" checksum="4FB157DADBD0FC55" modified="2022-01-19" version="1">MRTGSSFVGELLGNSQDIFYLFEPGLSLLNTLEGLEGQREVLRSSYLGMLRRLYRCDFKHLDFYLEWLSRRQTLLPKFAPRLHDLCSNSLIRGKCMLTRGMATGSCLQSGYIVVKSIRVRDIMVLLPMMEDSATNLKVIHLLRDPRPTIASRVLAQTKKKVTQLSQSVREYLYLHCKFNLENFELGTRNPYIKNRYMFLRYEDAAMDPLAAAKRMHRFLGHKEVPESVLKWIAANTESKKPALTYSTARNSSEAYRAWRSNLPFDTAKEIEETGECPQMMARLGYHSLEDETHLRNMSRSLVGSIPIGHDDRKYDWVWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z7P8</accession>
    <name>A0A8B7Z7P8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110984789</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110984789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100977.1">
        <property type="nucleotide sequence ID" value="XM_022245285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z7P8"/>
    <dbReference type="GeneID" id="110984789"/>
    <dbReference type="KEGG" id="aplc:110984789"/>
    <dbReference type="OrthoDB" id="10198353at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022100977.1"/>
        </source>
    </evidence>
    <sequence length="215" mass="22242" checksum="CDAFA5CFB4F93A37" modified="2022-01-19" version="1">MEASLFVPLDGGVAFGLGAHTVNCQVNNSGNCPVMKGFTFNVLASPSINVPEDFGHCTPAGQIYNSYTVTWDRVTATNTNGQPILCLEGNRQVFLNGGSFGVGSHTITCSVTNNDGCTSEKSFTFNVVASPYLTVPAVRDQCTTSGLTSATVNWASVSGENTDGQPIVCSTPGLSSVPLGGGVAFGAGVHTITCEVTNNANCLASRSFSFNVHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z8X7</accession>
    <name>A0A8B7Z8X7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Probable G-protein coupled receptor No18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110985417</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022102118.1">
        <property type="nucleotide sequence ID" value="XM_022246426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z8X7"/>
    <dbReference type="GeneID" id="110985417"/>
    <dbReference type="KEGG" id="aplc:110985417"/>
    <dbReference type="OMA" id="CVSPIIY"/>
    <dbReference type="OrthoDB" id="10008828at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF72">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="43"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022102118.1"/>
        </source>
    </evidence>
    <sequence length="366" mass="40785" checksum="D2FB0F2EBEE35F06" modified="2022-01-19" version="1">MANIPGVSADATSLNSSYPQYNYEARVALAAFWILFTIAGFTGSSLVIWSVVLSKKLRTVTNAFVVNLSVADFWTSLSYPWLAVAGLSTTSWPLTSEIPCRIAAVQFDTGFGASLYILAAIAVNRMVMITQPIDIYRWLYTPRKVAVMIAATWILPWMVVGIPPLCQAGQLGFDITTRSCSIIESDENSASYKLTQTLGMYPIPMIIIISSYTALYVNIRRHFKQQRRRHVITKTPTVEMDLSDYCKTDPSRQSLGPTISSMSKSNIQAIKRQQLAITKNLFLICLTFTLLVSPYFLSLAAPHSSGFTPFAAAIATINSCVSPIIYTCNHPDFKVIFPKMLKCRYSEIPEPSDFLKYFLSRRKPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAD0</accession>
    <name>A0A8B7ZAD0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110985223</name>
        <name evidence="7" type="synonym">MED8</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101775.1">
        <property type="nucleotide sequence ID" value="XM_022246083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAD0"/>
    <dbReference type="GeneID" id="110985223"/>
    <dbReference type="KEGG" id="aplc:110985223"/>
    <dbReference type="CTD" id="112950"/>
    <dbReference type="OMA" id="FKLEHEY"/>
    <dbReference type="OrthoDB" id="150687at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="195"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022101775.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="27804" checksum="3C4331AC9F2C1384" modified="2022-01-19" version="1">MQNQEKALEVSLEALTNRVQDLKTSLIAFLEKLEREHETLKWTAVLNNFALLSGQINMLSKVLKSDKTPALRNLVLLPLKLSQDRDEELEKMTEGRVPAFNHEVVPNYLRTKAEPEVEARELQLKQKAATITPEQAQQKQINSMNKLVTRLLDMVSSAKDDWDGDGAMRLGNLGNSNHSDTTTLVSAVTIGRNLKPIRPPVQGQHNVPGPPGGPPLSQQQRPEQHVPMGKAPSAIKTNIKAGSSSHPYGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAL4</accession>
    <name>A0A8B7ZAL4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Diamine acetyltransferase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110985347</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102007.1">
        <property type="nucleotide sequence ID" value="XM_022246315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAL4"/>
    <dbReference type="GeneID" id="110985347"/>
    <dbReference type="KEGG" id="aplc:110985347"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022102007.1"/>
        </source>
    </evidence>
    <sequence length="82" mass="9573" checksum="4C5C335175D8226D" modified="2022-01-19" version="1">MIFLGEFYIRTAHRGTGLGKALMEKVAEQAGIKDRCKGMNWLLRASNDSTWQFYRRFNAIDMTTQHEWRFMRVKGDSDAHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAU4</accession>
    <name>A0A8B7ZAU4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110984458</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110984458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100366.1">
        <property type="nucleotide sequence ID" value="XM_022244674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAU4"/>
    <dbReference type="GeneID" id="110984458"/>
    <dbReference type="KEGG" id="aplc:110984458"/>
    <dbReference type="OMA" id="YEHIGFP"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47708">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47708:SF2">
        <property type="entry name" value="SI:CH73-132F6.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="3">
        <location>
            <begin position="547"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022100366.1"/>
        </source>
    </evidence>
    <sequence length="662" mass="70649" checksum="A98E2085DF7AD195" modified="2022-01-19" version="1">MEKSSVFFNMAASMLVLNSRGLSKFRKISSNLKRIKPEHFSACVLQSSVRNFSEILGGRTTRIGYASGFWGDTACAAPQLVHHGQLDFLVFDYLSEITMSLLTAAKHKKPDLGYAPDFVQAAIGPLINDIKRKGIRVVSNAGGVNPHACAAAVQEAAKKAGIELKVAVVIGDDLMNKRDEIIASGTTDIDSGIPAPKSLVSMNAYLGAGPITKALDMGAEVIVTARCVDSAVVLAPLMHTFGWEPTDYTRLASASLAGHIAECGAQATGGIFTDWHLVDGWDNIGFPIVECGADGQFVITKSPNTGGLVSKATIAEQIVYELGDPGRYVLPDVICDFRNVTLQEIEGDPNGAVLVTGARGLPPSSQYKVSGTYADGFRATAVCPVTGPNAAEKGRKTAQSILKRTRTMFKHLGLKDYTQTNVQILGSEQTYGPRARDINPREIVLWMAVEHSQRNALEVFSREIAPAGTGMAPGLTGIAGGRPRVSPVLKLFSFLYPKDQIEAKVHLDGKEESITASTTDASQDTQPAEETGAPAEEVLEGGSHSFSLGELAYTRSGDKGNNATIGVIARHVSYVPYLRKALTPAAVQEYFLHLIDPNTPNPVSRYELPGINGFSFLLRNSLGGGGVASLRSDPQGKGYGQMLLDFQITNVPDLLSLAKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZB58</accession>
    <name>A0A8B7ZB58_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="18 19">Metabotropic glutamate receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 19" type="primary">LOC110984512</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022100465.1">
        <property type="nucleotide sequence ID" value="XM_022244773.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022100466.1">
        <property type="nucleotide sequence ID" value="XM_022244774.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110984512"/>
    <dbReference type="KEGG" id="aplc:110984512"/>
    <dbReference type="OMA" id="VWNEAKL"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007206">
        <property type="term" value="P:phospholipase C-activating G protein-coupled glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15285">
        <property type="entry name" value="7tmC_mGluR_group1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000219">
        <property type="entry name" value="Glutamate metabotropic receptor 5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07562">
        <property type="entry name" value="NCD3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00979">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00981">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="724"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="839"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="876"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="905"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="16">
        <location>
            <begin position="684"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="985"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1052"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1145"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1278"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1281"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022100465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022100466.1"/>
        </source>
    </evidence>
    <sequence length="1422" mass="155894" checksum="89C062A6CE03518A" modified="2022-01-19" version="1">MALPATDHLDYCMWQSHQCRHHHLGGFSGSRRTKSVRGSRRAPLRDVSSGTVLRDQRPGDARTPSGLGGQSDMTGPRSSDWQRTGLLAVWILVLVGSVGAASATVRTRKVARMDGDVILGALFSVHSPPSEGKATQRTCGEIREEYGVQRVEVMIKTLAEINQNPTILPNITIGYEIRDSCWYSSVALEQSLEFVSDNIGATGGSGAATGQHPASSRPAQDQCLPADGDAGTKVPPRKPIVGVIGPGSSEVAIHVQNLLQLFNIPQVAYSATSKDLSDKTLYEYFIRVCPSDTLQAQAMVDIVLRYNWSYVSVVHTLGNYGASGMEVFRDLATKAGICIATYGSINSNSSPDKFDKVIQNLLSTPTAQVVVCFCEGKTIHNLMSATRRLGLSGRFLFIGSDGWADRTEIVNGVEPEAVGGISIKPQTSYIHDFDPYYFALRPGDHSSNPWFREFWQVRFKCQLPPENNGSEPAETGGERYSKNCTGNESLAEHYSQDTKMGFIINAIYTMAHGLHDMHRALCPENTVGLCPEMKPVDGTVLLRYLFNVSFRGSSGDTIEFDKNGDPSGRYDIFNFQRLPSGKYRYVPIGVWSANVLDMNDSAIMWNNGSANPVTSFCTEPCEKGHIKDIRNNVQCCWACLPCKANEIMVDEFTCLECEKGWWPNEDLSNCTEIEAEVMRWGDIEAIMAVTFSCLGICCTLFVLVTFIRYNDTPVVKSSSRENSYILLVGILMCFLMTFIFIAVPTTIVCYIRRIGLGLSFCICYAALVVRTNRMARILAGSKKKIITRKPRFLGSTAQVVMTFLVIGVQVVIITVLVVVEPPDAVLDYPDPRRVRLICNTTTLGILGPLGFDTVLVVMCTLYAFKTRNLPENFNEAKYIAFTMYTTCVVWLAFISLYFGGSEMRNIVVCFAVSLSATVALACLFFPKTYIVLFKPERNRRSSMKTSSLVRMHVGSFSELAPLSSQKTSSVNGSLEMGMGRDRVARNSGFNRKGPTKESQKGFFSGIRRRKRGYNQVNMMKAVERDRMQRRRQPVYRYSASAETRPRRISGTIEDCAPLDPAGRGRADAPEGSESGPKIAVVRPRTDQSATNLQEVYIESALKDGPPGNIPSLLPGKEEALRRNSSSCASGKAADSVFIEMADEPEHGAGDMQSDARPLLTEPGDEAPPRRDSGLGLRPDIPQIVTSFHGSSQDLGEPQVGQMRNSLGTPPVNKRRVSESHGLPRPGANPFQFLPRRRSHGSVEGKPNVALCSAPPCKHSLKHRKQLAKSAEVLCRQGESNPLPTSSTVSSFSFTPTPHASYPGPTRPSSALDLVPSSLHLQDAEIASPPAKLNVTLENNNFELSGPSMRTHFDSPPLTVDCAMRSSTPSEINANENGLVSANGVDDVFDQSGSVWNEAKLEELATGQNTPLRTLPEIRSSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBI5</accession>
    <name>A0A8B7ZBI5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proline-rich protein 36-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110985554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022102347.1">
        <property type="nucleotide sequence ID" value="XM_022246655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110985554"/>
    <dbReference type="KEGG" id="aplc:110985554"/>
    <dbReference type="OrthoDB" id="10130023at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1377"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1512"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1547"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1565"/>
            <end position="1576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1584"/>
            <end position="1593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022102347.1"/>
        </source>
    </evidence>
    <sequence length="1609" mass="173035" checksum="C62852350E033B09" modified="2022-01-19" version="1">MLNDDTHTLSTAAVLDPECGKDSSWPNSTRRVWCNDQDGYCRGSNKIRTGSASFILSRPKVDRKVKLKTKLKEGPVDGPSSLRTYREDIRQILFKEFHSPISDLEIGVVVRQAFPRHSRKGKYYLGIGTCDAEDADGACRKITTDNPKSLMTVQSDGDSREPSPVMLKPVKKRAIQEWKETENGQAFAADQLIRDANNQPSAPAVSVAPSDGLVEPPWRPMLMLPQPLPMSPRGMLFPSGQLTVNLSRNLAPSRARKRPSTDLQVGGLHKMGYGAERVGKKPRKEGAMIELSSSRNGLIADRTKLPAKHIQPIILDFDVTPPKLPLRVPSPVSSGASLDQANANESSAAKERSKSEETSDGKKDRMPVSPHSADSAESSHSKPEDSPNKLLQVPSSDPGNSPDSKRSLDNKSPHPFKKPDIDSYRNNVSAGRCFMCQSPIPPNSSKDASQQESAILSICMKCKKVAMSGSTSLKPVPKFPLACNPTLAPRTVYVPPPRRQTRPRPPAPTGPQKAVGIRLYPPRSRSKSSSSQRSTPVQSPLAPPSSPGQMSMPGSPAPSLPMGSPQPMSPAIIMHSAPPSPRHPSDAGLKMSRSLPPSPSMIHQHPASPAAPDAREPDCSKKLLPSASLQVPSPYSSNPSTPGGRDSSSSEKLSLPPGREQDDATIKALLQLGRGFERAPSEHSTDSTPVPSPTSRPPEKDSLPMPNPTNSIPIPHSPTSIHIPHVAMPGSLPHLAGQVPMIPSNAGVVMGPEGQLLPIIPSWAPLGVPTSEALNILSHGCSPVPLLIQQPMTQESSSPIVSVATLDPASSGIRSRTLPEPSKTNAGLVLDSHTQDLSTLKYRKGLKRSRVLERNTDSPRADPTHEDKSKPPIVIVGTNCAGSTSVKLKNNSREPLYPQEPVSRELPGMYGKLFTAFCCRCSGREIMLLQCPDCDFVCNTKCGMEQHIAAQRHMESHGKGSMLEAMTRQANEADDRDEIGSQSSVETQSADTDPDAASPPPTRIPREVPWARITDPTSQVPVPLWQNNLLNVMPERGIPVETTPPRPSQAKFVVSSSFGSFGTVTENTVPLDLSGRTFHPAPYFPFELKEPRRESSAEESSPLDLSGYSRPSIMSTEGNGSLHPFLSSRKLGPQAGITPKKTPLDLMSSQQPSTAPGLIVASPSIKKCPQPPVPHTFFDLMRLHGMPVPTTAMMPTLNPSKGLQSSSSSKLPTGRPPPDPSLLSVARTQPDNPSSSKSSPIIPSIVLSSSSSTSPYVSKALSYPTTELTRPPPGVITSPILTKPQSLNFQGGTISIRPTIPLPQALVSSKTVPVLSPFLPPGSGPASASETRTSPGREFPHMDLLSVSVGSPKVNVGSPSRISPSVRESPKARHRHNALESPREYSGRKDPSPVRSPQQVHIKIEPPDSLQEVEYCQRAVENNREQQWHKEAEEQARLLEASLVVPHPSPVRSRVVTVAPSGIGRTMWGISSKSLQIRDSGYVDTMANFPTSPRTVSDRPLSGTSQRHDTHSGASESSGGQRTKLSAREAVDAPATSPDVQENYLETPEEASENGEEYSPPGHTVASSGSTGQTFRVPTGSDCNDNRSDKTDLITEPVSPAALHIKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBL2</accession>
    <name>A0A8B7ZBL2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110985915</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110985915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103069.1">
        <property type="nucleotide sequence ID" value="XM_022247377.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022103070.1">
        <property type="nucleotide sequence ID" value="XM_022247378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBL2"/>
    <dbReference type="GeneID" id="110985915"/>
    <dbReference type="KEGG" id="aplc:110985915"/>
    <dbReference type="OMA" id="SDYFAWC"/>
    <dbReference type="OrthoDB" id="544608at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34407:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022103069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022103070.1"/>
        </source>
    </evidence>
    <sequence length="568" mass="65999" checksum="97BB63DB987CE551" modified="2022-01-19" version="1">MRVSMKRCTLIVIGVLNGVIIFFNYRAMSEESRQRSTDFIRSKFDFVKKYVHPQDRDNNNYAKDEQKRKQPLVWNDIQGIHKALPAYGKMRRVLSNLHDYKRYFYRESVYFNINGEMLQYKSVPHVGDSYHLRALFADVLQTNRSLRIGVIGGALSYHNVCLQKSCLYIDIVANWLMKILDTEVTVHNAAIGTTNSDYFAWCLQPHLDVENMDIIIWELATEDYVNRDVYFKHGLTNAAWPQEEITRRILALPNKPYLMYFNFLSTANIRQRECVNSEYFAGRHLAKHYNVTSISWCNAICTKLWKPGFTPDDLIFADNLLSKRAHHQGALFIIHYFRNILEEVTENFLNQTQYNKRYIKHLIALHDDFVQNTYGLGSQPIKTIKSKTHSNNITAKFSHVQLKDPQCWPISKPQFESNHSLEITMNEGWEIGYSYNDNWYLSTEPNQRITFKISIPPNWKNLNATIAIALVTCNYCGQALVWLNDLFGGAKLVSGNDKIHQFAVREIFTNVPPASYSVTIKSMEERPVKIGAVMTSYEEPRNRTLLIKRNSEQFGGPRMWNKLKGPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBT2</accession>
    <name>A0A8B7ZBT2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NF-X1-type zinc finger protein NFXL1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110985943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFX1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103118.1">
        <property type="nucleotide sequence ID" value="XM_022247426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZBT2"/>
    <dbReference type="GeneID" id="110985943"/>
    <dbReference type="KEGG" id="aplc:110985943"/>
    <dbReference type="CTD" id="152518"/>
    <dbReference type="OrthoDB" id="536399at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd16697">
        <property type="entry name" value="RING-CH-C4HC3_NFXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034078">
        <property type="entry name" value="NFX1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360:SF1">
        <property type="entry name" value="NF-X1-TYPE ZINC FINGER PROTEIN NFXL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12360">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR, X-BOX BINDING 1 NFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01422">
        <property type="entry name" value="zf-NF-X1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="8">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="8">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="8">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="8">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="8">
        <location>
            <begin position="569"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="8">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103118.1"/>
        </source>
    </evidence>
    <sequence length="769" mass="86382" checksum="6F5B7576D8A96184" modified="2022-01-19" version="1">MQYLVDACRSGANVCLVCIGKIKRLDAIWSCCKCFCILHLSCVQKWAKEGALQNNMMLEDDAAVTNSSMWSCPKCRYESPSSAIPKRYTCYCGKVIDPPFHPWLSPHSCGEMCAKPLQPQCGHKCLLLCHPGPCPPCPKTVRSPCHCGRQTPQQRRCSSKAWSCGQPCSKILSCGQHQCLQPCHAGACDPCPRNSKQSCLCGKMKTTRQCASPQWQCDSICGRQLSCGYHTCQQVCHSGPCGDCPNAGKRQCPCGKTSFELPCTETIPTCGDTCDKLLQCGLHKCTRRCHTGPCEICRQFSVKKCRCGQREKSVQCHKEYLCDLKCQKMRDCKRHQCKRKCCDGSCPPCEQPCGRQLPCRNHKCPSQCHPGLCYPCQETHYIKCFCGSTSISVPCGREKVTKPPKCNKPCKIPPDCHHAVRDRHRCHFQRCPPCQQICGKSLPHCNHRCPWQCHSAVLVKQIENKGARTAPWEPLPKSHLTVMDKPCPPCQVPIPTECLGKHEVQDLPCTFARPFSCKKKCGRLLACGNHYCALECHIVTGAEDETKVYFGTQCQQCDEGCSKPRPIGCPHTCTKPCHPEPCPPCKQSVRQRCHCTMMLLHIECCKWTSAGNDEKARLASCQGACTKLLSCSHLCSKTCHQGDCSTPEECSHKVAVRCLCKRRKKDFPCKDVKGGQVKVECDASCKQAIAKQEKKKEEEKLQKEEQDKARQQRDLEEYERLTKGKKRRERRRKEDIVHPSFWQKHKKLILVSLPVTIVAAVLLYGLLWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZD39</accession>
    <name>A0A8B7ZD39_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAS-associated factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110986203</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103589.1">
        <property type="nucleotide sequence ID" value="XM_022247897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZD39"/>
    <dbReference type="GeneID" id="110986203"/>
    <dbReference type="KEGG" id="aplc:110986203"/>
    <dbReference type="CTD" id="23197"/>
    <dbReference type="OMA" id="ILIRHQW"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16120">
        <property type="entry name" value="UBX_UBXN3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049483">
        <property type="entry name" value="FAF1_2-like_UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054109">
        <property type="entry name" value="UBA_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22566">
        <property type="entry name" value="UBA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="5">
        <location>
            <begin position="372"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103589.1"/>
        </source>
    </evidence>
    <sequence length="459" mass="53763" checksum="6FF0986D363329EE" modified="2022-01-19" version="1">MAEYNGNNQEGPDAPDGEITTEQTEKLIQFQDLTGNENTDECRSILQRHNWNIETAVQDTLNVNEGRPTVFDTPRSRIETPPPEVNTYSSDQRIYTVQRAQPRPSLLQWGYMAILFPFRFVTFTLWDIVQWVLRFFRPDPRRTVTDPVGDVVSFIGRFNEQYGRDHPTFYQGTYSQALTDAKRELKFLLVYLHGDDHEDTPVFCRETLCNNEVTEFINTRMLFWAASINTPEGYRVSLALREPTYPFLALIVLRENKMTVVQRIAGAIQPQDLIDRLNRVMADTEAYLVSMRHERQQRVQANTLRQQQDEAYHESLRQDREKERRRQEEKDRKQRELEEELEKQIQEQRRIQEREELKLAKAASLPAEPDPTNPDAIRVVVKLPCGTRLERCFLKTDPLQVVYDFVFIQDDAPSEFRLHTNYPRRLLPCQAVPEPDDDTTIQGFGLAQKEMIYVQDTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE37</accession>
    <name>A0A8B7ZE37_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 SUMO-protein ligase NSE2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E3 SUMO-protein transferase NSE2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Non-structural maintenance of chromosomes element 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110985057</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101466.1">
        <property type="nucleotide sequence ID" value="XM_022245774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE37"/>
    <dbReference type="GeneID" id="110985057"/>
    <dbReference type="KEGG" id="aplc:110985057"/>
    <dbReference type="OMA" id="NHHYDEG"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="14">
        <location>
            <begin position="147"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022101466.1"/>
        </source>
    </evidence>
    <sequence length="235" mass="26574" checksum="806330101563AE2F" modified="2022-01-19" version="1">MSGIANLGMVDGALQSVDKVQSYITIGMEDIIEVSLDLAETATEGDGTETQLEDLKKMMEEYASMEQDLHQYVKAVKQVKGQIQRLGIEEQMKVEVSQLVRQAVADIQKKDDDGQLGRHSKMDELIQKMWQYRNAGDSIPTTSNAQGDDDVIMTQCEVTTVCPITRCEMTDPVTNRHCQHNYERAAIMQIVKNRKNAKCPVTGCGNQIPITKSDLVDNRQLKRFIEHRNRQENRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFK7</accession>
    <name>A0A8B7ZFK7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Steryl-sulfatase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110986317</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103782.1">
        <property type="nucleotide sequence ID" value="XM_022248090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFK7"/>
    <dbReference type="GeneID" id="110986317"/>
    <dbReference type="KEGG" id="aplc:110986317"/>
    <dbReference type="OMA" id="IAPGLWI"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.10:FF:000001">
        <property type="entry name" value="Arylsulfatase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.550">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF49">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034114512" evidence="7">
        <location>
            <begin position="16"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="33"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022103782.1"/>
        </source>
    </evidence>
    <sequence length="604" mass="66955" checksum="F550E8EA658BC45C" modified="2022-01-19" version="1">MELTWLFSTLTLATCCQIFCAGTTGTCTSKKKPNFVIFIMDDVGMGDLGCFGNNTMKTPNIDRLAQEGAKLNHHLALPLCTPSRAALMTGRLPVRYGMGSRHIMRVFTFLSAKAGLPSNETTIAELLKESGYSTGLVGKWHLGSMCETETECSHPNGQGFDYFFGLPLTNLRDCGGKSNVFVAWDPHIYRDIVLTFLVLLWAAYTVRKHGYIGPSGFVMCVAMAAVLCGGFFAFIKSVRMMNCVLMENQRVVEQPLQYNCLTERLNHRAIDFLEQAHDQPFLLVVSFLQAHTALFRSEHFVNHSQHGLYGDVVEEMDWSVGEVLAALKRLGVDDNTFIYLTSDNGGHVEEFSEDGEREGGWNGIFKGGKASTWEGGIRVPTIVKYPGVVAPGSQISEPTQLPDLLPTIAGIVGVQLPNDRVYDGKDLMPLLRGENNRPHHEFMYHYCGSYLHAARYTPSDSDSVYKVHFSSVLHVPGPYGTMGCFGTYACRCTGYSVIQHDPPVVYDLTRDPSEQSPLDPNDPVVREVILRMQDAVSEHQSGVVKQQDQFGVLRLLPRPWKQPCCGTFPFCSCKDSLHSESLTLPSAPVTQPDWVPVAEEIQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZGD2</accession>
    <name>A0A8B7ZGD2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11">Neural cell adhesion molecule 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110986479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104052.1">
        <property type="nucleotide sequence ID" value="XM_022248360.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104053.1">
        <property type="nucleotide sequence ID" value="XM_022248361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZGD2"/>
    <dbReference type="GeneID" id="110986479"/>
    <dbReference type="KEGG" id="aplc:110986479"/>
    <dbReference type="OrthoDB" id="10056271at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050958">
        <property type="entry name" value="Cell_Adh-Cytoskel_Orgn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080">
        <property type="entry name" value="CONTACTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45080:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665712" evidence="6">
        <location>
            <begin position="20"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="121"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="216"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="306"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="414"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="8">
        <location>
            <begin position="703"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022104052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022104053.1"/>
        </source>
    </evidence>
    <sequence length="1030" mass="115088" checksum="B08E08B6161EF095" modified="2022-01-19" version="1">MLSWKLVLLALYAVGFSDAALKIEPIYPTFNVPEYGSATTTCTNMDLFGTQPEWVDPYGQVVGPAGGGGSNDKQVSFHTNPDTGLKYTRMHLSNILKAASGGYVCRADGETQSININVYIPVTLVNEDAEKSQWMTYHESGSLLCTMRGEANTVVSWDGPNGPITDGGRYLITDMYGLTIDNVTLNDEGSYNCRGSIPDIGVATVLTIQADVYMVPKIRYPPINKNATEGTSAFFTCEAIGEPQPDYTWYDGSEALEDPAKYLIEEDGKRLTILNLEKDDQKRYTCQVSNPAGYDRRDGVLTVDIPPTPTRAVTQEKDERESVTFFCDIMRGDRENLALQFKRYEKWLPMGVQVDSRIVIQQETGTGPDAGQPGSLSLTITDIHRGDEGDYTCFARNNGGYAMSHHFLHVRYAPVINLDYSTKKVYSWIGHQLNLTCHWYGYPVPIVYWFVNSQPLVGTIGDVAGNATIYDFNNGSSSLFIDTKDSDFRPYQCDGRNKFGRVRHHIQFERAYPMKRPTNVRAISASSTAIQISFDNPVEVGADFPEYLRILGYVIGYSEYQQPTEMYEIIQNMCEPTAFQCGLLCIEKERRCDNFMDCLDNSDEENCNPQEDCPGGFKCPVRDGNLNPCLPLAYVCDQQADCVDGADESEESCSAYYRPIFYDMRLKGLAPDRIYQFRVAVMNEVGWGEWSFNTTERTLDYGPPSEPMIFNREPERNTMYEVVWLEPYDNGGSPILSYELTYSRVETADAKEHGRDPLTVPASKESETAPVFRHTLTNLERGTFYFLELRAVSTWGKSSPGTLNFRMPGGAPIPPPSNEPLGPGLRIGDLPLAAFIGIVVGSFLVILILLDCLCYCTNSCGLTMCICVHLCGKQSPEAKEEMEAVEYSAAMSTAGNRMAMQRLKDFETESHAVSDGASQYQSLHTSRLPDDRWRVPTQAPYEADRLLQGTTHPLTDLSTLPAPIYGDLQPPSVPSIYSGMSASANHPSYRGYMYPSSEPTYANSDLFDNTDPRYRNEKMELERDLKNIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHJ4</accession>
    <name>A0A8B7ZHJ4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110986990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105054.1">
        <property type="nucleotide sequence ID" value="XM_022249362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHJ4"/>
    <dbReference type="GeneID" id="110986990"/>
    <dbReference type="KEGG" id="aplc:110986990"/>
    <dbReference type="OMA" id="LRISWAF"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022105054.1"/>
        </source>
    </evidence>
    <sequence length="683" mass="77235" checksum="6F85B65AE8449448" modified="2022-01-19" version="1">MYPGTVYQLKHCRMNGQQQPEKDDLGADEKDDGAVELEEEGSGDENKERGNWSHPLDFVLSCLGLAVGLGNLWRFPFLCYRNGGGAFLIPYFLSLAFAGMPMFFMEVNFGQYCSLGIMTCWRAFPILKGVSYGQFLVCFYVSITYGVVISYTFYYFFISFTSSLPWVGCGQPWNTPMCSDIVMDCFQVEGVITLDNECVPLKNLTEFELEELNITVSDPGNFSLENYNDPWKAMRKSPSEEYWMGIVTQKSPKMNETGTIVWQLLLCLMCDYVITFLCQIKGVKSLGKVVYFTATFPYVVLIILLIRGLTLPGSDKGVYFFITPRWEYLVKPKVWLDAVVQIFYSLSVATGGLQTLASYNKFHNNTYRDLMIVSILNSATSILAGFAIFSILGYMAHVQGKEVSEVVRQGFGLAFVAYPEAVARMPASPFWSILFFFMLITLGLDTQFVGIERLATSLVDEYPRLFPPRRKSFVTLGICVVLVLSSLICITEAGPYWMSLLDNYGANFAMVLFAFLITGGLSWGYGVRRFINDIRTMIGDRYVDTLHFKWWTLNWVVLTPLSMGVILVFNWVSWTEPEYNGSYPPWARALGWMIMITTLIGIPGHVVFELLRRKGSFMERFRNITSPLDSWGPALTQHREEAAEVHRHHGTTMGGVVCLAEVNATSRTVKYATLGKDEMEVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHQ1</accession>
    <name>A0A8B7ZHQ1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Very low-density lipoprotein receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110985785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102791.1">
        <property type="nucleotide sequence ID" value="XM_022247099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHQ1"/>
    <dbReference type="GeneID" id="110985785"/>
    <dbReference type="KEGG" id="aplc:110985785"/>
    <dbReference type="OMA" id="SCWCVDW"/>
    <dbReference type="OrthoDB" id="9988974at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000034">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="8">
        <location>
            <begin position="192"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="212"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022102791.1"/>
        </source>
    </evidence>
    <sequence length="264" mass="29606" checksum="CC5A8321BC70F556" modified="2022-01-19" version="1">MYSWNYDPNYVTVTMGTNQENTKKHKVQLPSKYDQVVFTPSEEEDQEAVELAYALSLPRRDSEEGSVDLRNTTHSLKRHLRIVWCKKAAVGIAVALFLAAAVTIALVLVFGKKMSTQASGVNATISTTKIYEECAPNQFNCSPGDCIPNRWRCDGIVDCLNEADERNCDNYTATPCRSCKAWRDEFQTHCPPSVCPFYPSCTSTGHWEPVQCTLNNASCWCVDWNTGATMPGSLVEDVVKDGRPFCEMKPTQQNNQRDNRRSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZIG7</accession>
    <name>A0A8B7ZIG7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sorbitol dehydrogenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Polyol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110986784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104670.1">
        <property type="nucleotide sequence ID" value="XM_022248978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZIG7"/>
    <dbReference type="GeneID" id="110986784"/>
    <dbReference type="KEGG" id="aplc:110986784"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="10">
        <location>
            <begin position="16"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022104670.1"/>
        </source>
    </evidence>
    <sequence length="363" mass="38986" checksum="3515B15CF22F13A5" modified="2022-01-19" version="1">MSVTERNLTAVLKKKGKLVLEDTPVPQPGPDGEFYYQVTHNTKVQIRVHSVGICGSDVHYLVDGKIGRFVVNSPMILGHESSGIVSALGEGVTNLKVGDRVAIEPGVPCRMCSYCKEGRYNLCPDIVFCATPPVDGSLRRFYCHAADFCYRLPDHVTLDEGALLEPLAVGVYSCQRGGVKLGSNVLVLGSGPIGLMCLLSAKAMGAAQIIVTDLDQGRLDMAVMLGAHHALRVDTRDGEKMAHRVEEALGRKPDISIECSGAEPSVQTGIYATKSGGVVVLVGRGRYSLDLPLVNAAVREVDIKGVFRYVNCYPLALEMIASGKVDAKPLITHHFPLEKTLEAFETSRTGAGGAIKVMIHCDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJ63</accession>
    <name>A0A8B7ZJ63_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UPF0472 protein C16orf72 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022103326.1">
        <property type="nucleotide sequence ID" value="XM_022247634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJ63"/>
    <dbReference type="GeneID" id="110986043"/>
    <dbReference type="KEGG" id="aplc:110986043"/>
    <dbReference type="OMA" id="NSFEEEC"/>
    <dbReference type="OrthoDB" id="5823474at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040308">
        <property type="entry name" value="HAPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31624:SF4">
        <property type="entry name" value="CHROMOSOME 16 OPEN READING FRAME 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31624">
        <property type="entry name" value="UPF0472 PROTEIN C16ORF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022103326.1"/>
        </source>
    </evidence>
    <sequence length="257" mass="29125" checksum="FF28FADF16B41534" modified="2022-01-19" version="1">MSEQKERGDDSGGELWASSWEQQCLEEFDSEPNLDERLPQERQVAADQLWHSFQACASAVTHLYKLERLCNPSNALPLWLAFQNAASSVTRLYKDSLEAHRRTSEFGTQIGHQRRTRDVVGWVKKRRRYIKREDLLAFLCGKAPPPRIRPSPGGRGVSERSSPRTHAQSHDVGHAVETTDDLQPFREALALQGLNGAMANVGVSQSPPHHSHSRRRHGNVLDLFPDELFAHPDSRKRNPSPSDVHMDSPSHKRNRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJA3</accession>
    <name>A0A8B7ZJA3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">X-linked retinitis pigmentosa GTPase regulator-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110987310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105614.1">
        <property type="nucleotide sequence ID" value="XM_022249922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJA3"/>
    <dbReference type="GeneID" id="110987310"/>
    <dbReference type="KEGG" id="aplc:110987310"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="4">
        <location>
            <begin position="47"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="50"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="121"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="176"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="251"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="301"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="349"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="402"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="644"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="681"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="787"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105614.1"/>
        </source>
    </evidence>
    <sequence length="863" mass="93513" checksum="16EE43FAE346F22A" modified="2022-01-19" version="1">MDTKRTIEDNSLLQSATSDDATSSEHPGDSLVANGQRIQTDTSKMGTDDGHILSWGCGEFGQHGHGHMDNVSPDGSLLKHFYEQIAKMAGTREGLPRGGTVPRLKTFACGASHTIVVTASDQVYSWGNSNSGQLGCGDKETHLTPQRVRLPGEAKASPIKGLACGSRHSVLWLENGLCFSWGNNFYAQLAYDFRIENYKDNQATRQFLLQHLVRKNICDEVLPHLLRPIAHLKVTQVACGEKHSLFLYETSIVAACGCGNFGQLGSGNRAELVSPKVLELPEGVAFIACGANHSLAVTATGELYTWGFGRACGRRREDILQPARIMTRQSNVIAATGGSAHSVALTANGTVYTWGGGTEGQLGHGSKVLYLGEPRPLSHDALPRVSQIACGDSYSAAVTPNGTLYMWGKNSHVIPTSDKPKPYCQQPTPMKVSPGGQPVARVACGSWHAMAVVGTPEWQPLQEDSEEELDPNISIGMWGDGDFSDSMEVGEGKDMTPEDASNCGSAFQEQPGLSDQQTHPVQREATKLTLAEFYAPTPLPAISVPEDYSDEMDSELDTEKTDPKVDEVYQGEQAVLNSEGTMLELDSQAVDEAVEEEGIPAELDSVDKSLTTRFFVDISGTSVEQRTLKNEVLETERSNIVKGGVSTRSKQHQSQPQESTMVRSKTMPVVTRKPLKMASASTTAAFNWSDPPKSSPETEPTSSRFVIHKHVSVQLNRKGDGSSDRTRGRKPIAQVGLHGSGEGDALLSRSKERNVMPPPPNFNRAKTYYGRMSQKRPEAEPRLSQFLSSLPPAPSQTSSAPTKLQARKRLDKPTGPSDRSPNWVKPHLLLVSTSAEGRGQIPGKPVFSSAASWRTRSSEEDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZK47</accession>
    <name>A0A8B7ZK47_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heparan-alpha-glucosaminide N-acetyltransferase-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110987515</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105998.1">
        <property type="nucleotide sequence ID" value="XM_022250306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZK47"/>
    <dbReference type="GeneID" id="110987515"/>
    <dbReference type="KEGG" id="aplc:110987515"/>
    <dbReference type="CTD" id="138050"/>
    <dbReference type="OMA" id="ITIYCGH"/>
    <dbReference type="OrthoDB" id="2149840at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061:SF24">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034026300" evidence="3">
        <location>
            <begin position="26"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan-alpha-glucosaminide N-acetyltransferase catalytic" evidence="4">
        <location>
            <begin position="245"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022105998.1"/>
        </source>
    </evidence>
    <sequence length="636" mass="71330" checksum="46AF627BBC198B8F" modified="2022-01-19" version="1">MLLFLFSAVVFGIAVFAVDAPGCIGSTELPQHSAGLTQSAVKEMSFTSGRQDAFGYHNIRRDTAFLYVVNNAPTGIAVWGQSHECYQCKLLRLVEVSGNTSLLVPVYLDTWWKLTLAVTHANEDKVNASTVLCNQLTEHFGENGNYSLFINVNKSATDNSDVCLIFTNREPDNANIPIYVAMGIYAFLALMYSLFSFGYRNGVLSTFFNWCITEGVVNSDLGSPPSRQPITTNTSVNKDPPKPRRLKSLDAFRGISIVIMIFVNHGGGGYWFFIHARWNGLTVADLVFPWFVFIMGTSMSLSFSSMIRHNVSQWTILKKIIRRSLILFGLGIMLDGGTDLSTFRVPGVLQRFAISYLVVASLHLVSAKPKVEDYRITKQYRLMFRDLVDYWHEWLVIISLMVLYVCLVFFLPVPGCPTGYFGPGGPLVDGHMNLTNCTGGATGYIDRWILGEKHLYPHPTCKKVYHTTVNYDPEGILGSIPSIFITFLGLQAGKILLLHQYNSSRIIRLLLWTLITGGPALLLCEASKEEGWIPISKNLWSLSFVLAMAGTSFLLLTFCYVTIDMKQWWSGVPFFFAGMNPITLYCGHEVLMDYFPFSWTAVYGSHAELLAMSLLCASLWVAIAYYMYRINFFVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZL50</accession>
    <name>A0A8B7ZL50_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">DNA endonuclease RBBP8-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC110987390</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105775.1">
        <property type="nucleotide sequence ID" value="XM_022250083.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105776.1">
        <property type="nucleotide sequence ID" value="XM_022250084.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022105777.1">
        <property type="nucleotide sequence ID" value="XM_022250085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZL50"/>
    <dbReference type="GeneID" id="110987390"/>
    <dbReference type="KEGG" id="aplc:110987390"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="5">
        <location>
            <begin position="831"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="5">
        <location>
            <begin position="872"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="551"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022105775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022105776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022105777.1"/>
        </source>
    </evidence>
    <sequence length="936" mass="104357" checksum="36C42B6D5B83D64E" modified="2022-01-19" version="1">MSSDGQDGAIQLDSLEIPTASYTLSNSTTSQMSSPKVSFTSLLLQIQQFHTTELQKLQDKISRWKMRCNKLAKVSNENASIAKKYYNQNKLLQAKVIDLKHQLRVLPSARHDGVIDTSKMPARSGDQASPKLKTRLANGSPNKNLLKKAFHLPSRLTSKKSNKKVRYSEITSIRSGQNPSIETSQFNISEETQKRASITPSISGMTAQKKTLSICQDSLNQPVAIASQGGNIVVPNTCVSPSIQDPLNLRSSKPGAMMVGQDTSRQTLMSDPITRIKDQIIHTVPETLGLDIDNGTVIEIDDESLIETPTFASTPIVNHSQMSLLSEPVSVQMLNSLQNPGSPRLNNSPVETSKRQPSQIVPLTTSMPRSESQYPVDLNSTQVKSPTFCGEALATPESASGKSWQHSKNDLSRNIPTLYGGDQFGACATDESYQSEASMLLLRPHVPKRFVHPHSSPQDLPDNRVTSMKATILQEACKLKQEGKTSPTYMCSTRMARDMRSPITPASASEEKHEQGTNMMLTLHTNVLRVPTSKKRKLDLDESTVYDDTVCPSHKALGKENSPERLDDTNQTSSDQKSSKQTNQGKELVEKTVAKVQAKGMKNLKQSKLTLKKIKPGMNKSARLMREYNEDSLVNIDSQVDTFINQAIELSLREKNFRGNELGSKDVEEGFKVPNVPQKKQQYPVSLDTGVIKKASHQDVTEADQIDSDLSHILDLTHSPHDLNGTIDPLMDLTRLETGASQSTHQVNLSDRGGSHDHKLLERNLEAHLKAGDRDLNMSEAGDDSCQDLFGDEVNKDKPSEMMEISRDTDEVAFVKNFDVIPKVMDKPNYKYTEVVRKHDERQKLRGFGCKDCEAFYRDLSLTSTQQEMRMKLCSRHRAQSSPTNTPEHYWSVGFPDTQTCLERGYIRESRSPERRSRSKKNKYKKLFAGKEGVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLD5</accession>
    <name>A0A8B7ZLD5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Pre-mRNA-splicing factor PRP46-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8" type="primary">LOC110986525</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104140.1">
        <property type="nucleotide sequence ID" value="XM_022248448.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104141.1">
        <property type="nucleotide sequence ID" value="XM_022248449.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022104142.1">
        <property type="nucleotide sequence ID" value="XM_022248450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLD5"/>
    <dbReference type="GeneID" id="110986525"/>
    <dbReference type="KEGG" id="aplc:110986525"/>
    <dbReference type="OMA" id="SVWENQC"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="210"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="348"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022104140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022104141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022104142.1"/>
        </source>
    </evidence>
    <sequence length="593" mass="65367" checksum="B0E4D48B2CCC9423" modified="2022-01-19" version="1">MASSIDTQTLSVEVRKLRKKLRQIDNLNRLDRPLLPEEEAKVAKTASIRSLLHEKLEELATAEEQELSDSQLSGTGSNVAWDTSQESPHHEANGLNEQIVDHEHSDSLDDMKRTYPDEVLEKSIVFSAEGDAGSGKSEAGNGESATDENSPPKVPRRDERSDEGVELRKASTSTQEKASSSKGKSKGKRRTTDSEEGESWAKVKFTVQDLEGHNDIICAVSCDGSRLLTGSRDTMVKYWDLDKGTELRSMGGHSGTITSVILLPADESSDLASCYDLPVSDRIGVTGSKDCYIKVWSLETGRAVHSVYTYNPVECLGYIPDRALIISGSDGGKVELWDIRTGSSVFSTIGHEDSVTCIHINNTEVYTASSDGIIKLWHLRDNSLHPTFVSENISSTSSSHLLARRHIRSLAVHGDIIYYGDDGLNVKALDWKKALVHKLKNHTGDFGSTDAMCSTQDLLVCAGYDLDNGCGYLNFWHLPEEVYLATLNDRDISRVVAIGQTQTKEGALRLITGGQELRVWDRIPRKRYSPQDAVPAEFNYSFSVKAQDSDLDSDTTDASDSERGGANQRRGRRWSEGSAGSAKQSWWSWCTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLK9</accession>
    <name>A0A8B7ZLK9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Tribbles homolog 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105780.1">
        <property type="nucleotide sequence ID" value="XM_022250088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLK9"/>
    <dbReference type="GeneID" id="110987391"/>
    <dbReference type="KEGG" id="aplc:110987391"/>
    <dbReference type="OMA" id="CFCLPPH"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031434">
        <property type="term" value="F:mitogen-activated protein kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000153">
        <property type="entry name" value="Tribbles homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024104">
        <property type="entry name" value="Tribbles/Ser_Thr_kinase_40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961">
        <property type="entry name" value="SER/THR PROTEIN KINASE-TRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22961:SF13">
        <property type="entry name" value="TRIBBLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022105780.1"/>
        </source>
    </evidence>
    <sequence length="341" mass="39137" checksum="7B6518BB6CFE709D" modified="2022-01-19" version="1">MNVQRSLPIPIQNDRSRRKAFVHLDTPPDLTNSYCSFSPNLSAPTPPNFVPKEPHVLSKIGGYLLTEETELSVFRALDAVTHEETKCKVVEAKKYTEKFAPNFKLEPHDNISQIQEVLIGEEKAYAFFLRDYGDMHQYVRSKRKLKEEEASRLFYQMVLAVVHCHEAGIVLRDLKLRKFTFKNAQRTELMLEGLEDAYILDNSNRDLLCDKHGCPAYVSPEILNSEPCYSGKCADVWSLGVILYTMLVGRYPFHDTEPSSLFTKIRRGKFTVPDFVSSQAKCLLRSIMRVEPAERLTAEEVLHHPWFRQNTGVINPFLDSSKMLDQTVPDFSLPESDDIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZLV0</accession>
    <name>A0A8B7ZLV0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110987444</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110987444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105870.1">
        <property type="nucleotide sequence ID" value="XM_022250178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZLV0"/>
    <dbReference type="GeneID" id="110987444"/>
    <dbReference type="KEGG" id="aplc:110987444"/>
    <dbReference type="OMA" id="TVFPRWE"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908">
        <property type="entry name" value="LD15586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20908:SF4">
        <property type="entry name" value="SI:DKEY-5I3.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022105870.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34420" checksum="408CD2F069C49BB7" modified="2022-01-19" version="1">MVMITAAFRPFVRKFYTKQLMSIPSLSMSTSTMDKAEIVNISPVLRLHKFNNDASAPLTLLLPWATATERNLDRFRTLYADRGFNVLTAYSKLINFIRPRSAQPVAAEIIDYLCTQTGKVPIVVHAFSIGAFMYANILIRMADQHQQFSALQPRIRGQVFDSLIIGTLKEMRVGLAHMLSNNRTLQWLISSSSAIYFYLTHSNTVEVYDQLVDIFWKNPFHTPILCYYSMTDPMCKVESMERFLKAWKERTGEVSHSHCVPNARHAEILRGGPEDYRVILFKYLDTLRLSDQSSPLHSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZM07</accession>
    <name>A0A8B7ZM07_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitogen-activated protein kinase kinase kinase 7-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110987573</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106097.1">
        <property type="nucleotide sequence ID" value="XM_022250405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZM07"/>
    <dbReference type="GeneID" id="110987573"/>
    <dbReference type="KEGG" id="aplc:110987573"/>
    <dbReference type="OMA" id="GDKNVMY"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031349">
        <property type="term" value="P:positive regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902533">
        <property type="term" value="P:positive regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01670">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF293">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="7">
        <location>
            <begin position="590"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022106097.1"/>
        </source>
    </evidence>
    <sequence length="671" mass="75075" checksum="B97B53A23E1D40A6" modified="2022-01-19" version="1">MASAFESSANRSEFSTQLPEIPKHFLTCKRKLGEGGFGEVYKAHHIQWGELAVKVCKQSTRLSDEDKKHVRREIERMTKVARHENIVSIRGIIPDVKPFDCCIAMDYMKHGSLRSCQKKLGTFPNAVKIRMIKDISLGMNFLHTQKEPIIHRDLKLENVLVNEHLVVKVSDFGLATWRTASNFKDAGGTISHIPPENLRNLNQKCTTKYDVYSFGIMLWELSSNQESYLNCKGNPSLISSGVARGQRPDMALIPSDEPAIVKELMEQSWHQDARKRPDFQEIKEKIDGKYQEYEKDFLTGLHETLKQLRELTAKQDESNTEVNRFPWEQQDIPDSKNETVKDGGSVEWRANGTPLTLQSKEPRVNDKDIHVGFPVAVSDAQKEQQPAGMSRLITPMENLSVNCDKYGMAETSPHEPTQLPTCVGQAAASVPDTSVPANCKSQYETDSLTDHLASSDQHHRLLSSGQTVKSPPSKQEGVYPAEDGKLSPPNLENRQSKTYHQTNVPDPYPREPPKGNNASGININVKGDGNVITVSRGKNTVQVDKQKHRERKKKKKYKTRSPTPSSSSSSDETDSSVPGPSITTSNESVTEQDIRDLDEHIGKKYKRLGRNLGLLEAHIENIEGDHFLGGRQEIAFQIMLAWQRSQGAAATKAALAEALEKTGLRNVAEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMG2</accession>
    <name>A0A8B7ZMG2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxynucleoside triphosphate triphosphohydrolase SAMHD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC110987827</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:46149"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>dATP + H2O = 2'-deoxyadenosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67649"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dCTP + H2O = 2'-deoxycytidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80083"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:80084"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17172"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:61429"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:15194"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>dTTP + H2O = thymidine + triphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80079"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:80080"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SAMHD1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106624.1">
        <property type="nucleotide sequence ID" value="XM_022250932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMG2"/>
    <dbReference type="GeneID" id="110987827"/>
    <dbReference type="KEGG" id="aplc:110987827"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000015">
        <property type="entry name" value="Deoxynucleoside triphosphate triphosphohydrolase SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2760:FF:000002">
        <property type="entry name" value="SAM and HD domain-containing deoxynucleoside triphosphate triphosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="15" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SAM" evidence="25">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="26">
        <location>
            <begin position="162"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="607"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022106624.1"/>
        </source>
    </evidence>
    <sequence length="634" mass="73146" checksum="6F39263968FDF122" modified="2022-01-19" version="1">MSSSRSKRKLSEGNLSSCNGCNSLDDKFDFADCENWTAEDVSKYLMAKGFTHEARLFQKEEISGKVLDKLTEELLQKKVGVRSLGKRLELLEEFQFLKKLQDNSRPKVFIDSLKVFNDPIHGHMEVHPLCVQIIDTPQFQRLRYIKQLGCSYLVFPGAAHNRFEHSLGVCHLAGTLCRTLQKRQPELSITENDVLCVQIAGLCHDLGHGPFSHMFDQLFIPAIRPDCGWTHEKASVDMFDHLIESNELNEVFVRYGLDDRDISFIKEQIAGPLEQKNTSWPYRGRPKDKSFLYEIVANKRNGIDVDKWDYFLRDCHNLGISSSFDCHRFMKFSRVIEVDGKKQICARDKEVGNLYDMFHTRNSLHRRAYQHKVNKIIESMLVEVLVKANDHWLIKGKNGKMLKMSEAIDDMVAFTQLTDDVILQIMRSDDPALAEPQRILNMVQRRQLYKCVGQTQPPDGTFIERNRVPKMKDEIVQVQETEDMDGPKLTPDQLIVHIVDLNYGMGHRNPIDYVRFYSKANPQQAVMVRKCQVSQMLPERFAEQHIRVYCKLRDPECISKAQRCFQIWCDKKKYTVQKPPEQGSGQVGILPTHTWLECLLAGNVLDPELTPAKPESQENPGTPEKKKSRTRLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZMU6</accession>
    <name>A0A8B7ZMU6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metabotropic glutamate receptor-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987904</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022106754.1">
        <property type="nucleotide sequence ID" value="XM_022251062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZMU6"/>
    <dbReference type="GeneID" id="110987904"/>
    <dbReference type="KEGG" id="aplc:110987904"/>
    <dbReference type="OMA" id="FANADCE"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13953">
        <property type="entry name" value="7tm_classC_mGluR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00248">
        <property type="entry name" value="GPCRMGR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50259">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034811496" evidence="11">
        <location>
            <begin position="21"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 3 profile" evidence="12">
        <location>
            <begin position="547"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022106754.1"/>
        </source>
    </evidence>
    <sequence length="830" mass="92527" checksum="D8EF97EDBFF236A6" modified="2022-01-19" version="1">MWTVELCVVVWLYLTGPGKCAVPSGVLVNYTRPGDFIIGGIFPLHQDNTCEAGMRSHILERVQTMVFAMEEINANYNILPNVTLGFDIRESCYMEDAALWSALSILSGHVPDGMHAVTTANAPRSRLVGIVGTSRSSTSIVAAKATNLYQVPMISGYATSDELSDKGRFPYFLRTAPPDKLQALAIIDALLRFEWRYIGVMYSIDTYGIRGTQELLNLADESGICVAFSIAVRKTATESEIQEAVSKILEFDKAKVYVMFGGYEGMYRILQEYHRIKPAEKLTLVGSDAFAYFEEHGLQNMSLGNLFFTLNFHQVPGFDRYFNELVATSMENPWFVEYKDLWKSELGCTDFNNCYIRTSNRSSPAYHAVYAFAYALDNMMHAYCGVSFANADCELFQNGISGPEFLPFLLNVTFEGIDGLFRFDENGDPEGTYNINSFRNGEYYRVGSWDSRGTDRQFSINKWDIHWPDGVGKPPSSLCVEHCRPGYIVVPLDKKCCKGCHKCASNAIVRGGACRPCEERFWPDEVTFTECREIEASTFAIDEVSILVILALSLIGICFSSLSFAGMTYYRNHPLIKATSRELSFLSILGTVLAFFILFAFLPRPTAVSCAISEAILSLCVTLTYAPTLLKVNRIFRIFDSSKRSTKPPRFVRPKDQLILSAGLISVQIIIVIISVVASPSKPEYLIPTPLEKYVEIYCQFGSGFIASCVYNLLLILACCYYAFKARKVPSNYNESKFIAVSVYSTLVLCLAAVPVYTTAVAVLQKVATLCVALLLNAYLTLVCVYLPKFYAARFVEDVRVMDWSSSIQDFRVKPASTVSTSADQPATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZNS1</accession>
    <name>A0A8B7ZNS1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Signal peptide peptidase-like 2B isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110987783</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106545.1">
        <property type="nucleotide sequence ID" value="XM_022250853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZNS1"/>
    <dbReference type="GeneID" id="110987783"/>
    <dbReference type="KEGG" id="aplc:110987783"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF103">
        <property type="entry name" value="INTRAMEMBRANE PROTEASE (IMPAS) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="9">
        <location>
            <begin position="66"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022106545.1"/>
        </source>
    </evidence>
    <sequence length="596" mass="65256" checksum="096F88844D7719EA" modified="2022-01-19" version="1">MYGGNTINNRGHRQLQVIADLGILSVRITSDGKLHHKEYCVACAQEAVLPKSLKNEDYHPVVDFSQSTLCVSPEDPNRLSGAVVEALRGNCTFLQKGLVAQDAGATSLLVVSATKITTPDVNQSKELKIPVALISSSDHKDIWVSGGQVSAALYNPDPPIFDYNLIIIWSMAMITVITGGYWSGLTGYKIAKTKERKERQEAGVADGERTGGDSESDTESEEEPMTITLPIIIIWVIMIMVMLLLLFFFYNYMVYVVIVFYCLGAANGLHTCLLPILKCIMPCKRRLPANKIPLLSSRPYIFSVVLGLACIGCVVCWFVFRHESFAWILLDVLGIAFCISVLKLIHIPNFKICFILLSLLFIYDIFFVFITPLFTKDGTSVMVKAATGGSGATEQIPVLLQVPRLSHSSGQVCQLFSMLGFGDILVPGLLVGYCCSFDFKTHSRIKAYYIASCVAYGIGLILTFVALVVMQTGQPALLYLVPCTVLITLAQATIRRQLSDLWHARQSRSHTRTGTEESTPGNSTEPTSNTSNCSRALDTPPNGTLTHDTPPDPQEEPPTPTPSSQMGQDQDGESDDITVETQPLLPLASMPVTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP53</accession>
    <name>A0A8B7ZP53_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein LOC110988307 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107368.1">
        <property type="nucleotide sequence ID" value="XM_022251676.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988307"/>
    <dbReference type="KEGG" id="aplc:110988307"/>
    <dbReference type="OMA" id="EEMEANH"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001313">
        <property type="entry name" value="Helicase with zinc finger domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000419">
        <property type="entry name" value="Probable helicase with zinc finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056787">
        <property type="entry name" value="OB_HELZ2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF16">
        <property type="entry name" value="HELICASE WITH ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25049">
        <property type="entry name" value="OB_HELZ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1525"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1687"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1812"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1551"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1576"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1618"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1812"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1823"/>
            <end position="1833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107368.1"/>
        </source>
    </evidence>
    <sequence length="3437" mass="388968" checksum="5A66DCDF146DBD47" modified="2022-01-19" version="1">MKSSVDGRLALQMSGEMGNRQITDKEPDLTLTTEDLQSAQTESGESNNDQSSREASSPDERDPSLTQADQAYSTVNQPLHCQSSQPMVAVDNQYTVLHDEMSSGDEEPSSRPSIPQPLRSQSYPYKTGQRKKPSKTSSQSTTSSRAPKLSPQSHQFLEKFHLRLACRECYDGKKCKSACKHQCRGNLLLCHLKSQSENGHKVWGVIRHRTRPDFKGQYQLCKNSRTTSHCWGKDCWYCHSEEEKYIWSAEQKGQFDRQEISEFLCREQNLQQNLPKLPPPPSSDTPDGFQVVSRRSTKRTTSETSTEGAACNSIPQKTVSRPVQRKNSTPIILSAAESRDEYSKLMAKVGGNFVYLCETCFDSSPPVMSKSSADGRHGTSKEQHPWSKVLVHVLQKDGKHQYLKIRKGARYKASLCRHIEKRFGCRRGDACQFAHNKVETEVWQCPVHQKDIVQFCEYTFIPRLPYRLMYVEDVPGVTSHQVVLYSDSRKEWHLVRERHPKFKPGKAPVLCRYGDHCRKYYCTYPHIPEEAELWTYMAKFNLRTLDEVISIAAIADSRQVANGTGASAPEPVRIQPFCCTYCDKHFERIAQLKDHLQTLGHLSRVDSDAEREWKHREPPWNLESGNYKLCEVVGGGTCLSGSSIGEDNSCTKAHSREELEEWKERYTYCMAKMKTAKERKLHSYMGDLLSMHEAGMDVFKEEVPGVEVECAEELRRCQEIESKAGSTVFPISWTFTIKAVNKKPLQEVGLLFPDPHIRFHLSRARDKHQVCSGGDLSDGSDTYRVQVVFSSETLGTFNQWVVFNFGSEPVLIRKLQVNVGARDMPIPSVPSRIPTEPWNNSNSQLVKYSDPANMTASQQAERNLVEGLQERYPYQAPHRYRDRSILSEELSCDNYKEVMHNVLYLEEKECSRKISKFATSSILKVASQVELPDGMHFAPRGYLFASIDLQQALIDDTVTSQIIIKSVHNILLKFGSTKKIYEAAIFTNQTFGNGTQHSMYVKLSPQCVADQQLISGTERDVTIQLQLDRTQFVFKHFAIDRLQHMDMVLPDPNKPQELPDSGQRWTDDGTNPRQDKIVHYITTYGGEGALSMPGMGPVLLCGPFGTGKTFTLATAVMETLTEQPESKMLICTHSNSAADLYITNYLHKFVQMSKSRQPDLKMIRIYATYRNISSIHHDVHDYLLQDNDGNIRLPSDEDIRAAQIVVTTLTTAVHLVSQTMQGCFSHILIDEAGQVLEAEALMPLAMATKDTCVVLAGDHIQMSPKIFSETVRSAGFDKSILERLFRAKACHVFLTANYRTCKPILDFIAKTFYNQAFCSKIDQPLHETLYPLMFIEVKGTDQRVGKSYVNTHEVLEVVRRVKELDQTWPAEWGPFRHESSIGVIAPCIMQVRVIRDALRKERLGHVTVETVDNVQGKQFRAVIISTVRTHKTLSKSSPSAGVLDEKDSEFYSSFFSDPKMLNTAFTRAQSQLIVVGDPAALCSVGSCSTKWRKYLKECEENQSLLPLGTTISGIHAEIRGASQRLNPNAVPFQPASYKKRNLPEDDGSEFNKASVSPQQGPDDQDGHSDTDSLSTYDDESDCEDDMLSELQRQVMEDEEDMREAAQQAESASKVHVQVARDEDDRVSNAKVHMKVAQGEGAEQESIAKVHQRWAKDGGAEQESIAKVHQRRTQDGEVEQESIAKVHQHRAQDGGSEQESIAKVHQCRAQDGGAGNPNPHHLKDQSVSKNHLLSSRTAILHGISDNQQANQEQAGPSKIQNTIQSQPVVKSDIQMKPGGSKTKGKKTTMIRADHLLKFKSVYRSGLVGAADYEDGADETEEEENLKMMDKESQREGLRLVERQPDKYKICSFKFEISAFAYAVPRGENSSKQVCINGRKNRGQALHLDEVVVEILEGDADGDLETTDACVETKIYGKVICILKRTTNPKRMKIVCTLDKYTDNLMVPVNHTFPKLYVISGKGVMKGRKTSGPSADFVPVSVFRSKRPHGQMCLERVVKVSRQDRQKKLFLVKYLKWEDDNRYPVGYVTEELPVGDNKEDGLLILKHIHGVRDAFPLTAIRDVESICPSDWLIPDEEMQSRKDFRRKSVFTVDHPETQDIDDALSIEVDNGIIEVGIHIADVSHFVPVASALDKEAMERAVSFYPAFSEPVGMLPPQLSTNLCSLLPGQDRLAVSVIFTMQQDGSISQSQFVLSVINSKKRVTFKEAEQMIMTSDHQQEGSIEEKIRLLSKLAQARRHARLSDGYLAYSHNPEEKELCHPLASSMVEEMMLIANEEVSKFLLSRFPDLTPLRSQLPPDEEKVTTWLNNHRENIPNSFYLQSDPTLQGKGECTNAHEDVNILKDTMKKLLAIIHLPNEASQKMVKITDIICSDENHPQLAVAQAELHHLQERATYISSGDYEDGQKRKHHTLKKPSYTHFTSPIRRYIDIVVHRLLKAELPNRGEELRPYASEDLSLICHHCTNQSIMAKHFEKETMSFHLALKLKETPHKVNAFVHAIGESSLQLMFPYRSFVPRTTQTVPYQHLSPMTKPDLTDATEVNLAWKMRIYDVNMPPIQSIKSPFKLDSEQSIVKIPSADMQKLLWGIKNNNFNCIQCVVKRVNKNHLQLEEDKSQHLKAPDGTSLPVAEIAQTVDSDGNPFPFTDFFRDFKQSDVVEVCLAVSISRGMIQPSVQHFKLTPKLGLCQEHRDEPAESFDVVASKRAVRCSTVEKYQNIWLPILEVMSVHNAVHSNESIFIQGLKINWDYDRSTGTWSGRFSLTASFCERWHIRFSFPNKSEESDKPDNEEMSKELEVDLDYLCISYTDLPLSDEAKVALREQQYKLQSSTDLPEGMVVTAHAAVTDVTRYKGNQIVHFDVKKLSSPFPKILLESAERFFCTVEVIPKQEQDRRLETAVRSLEKASPLIKDICLQRRPVGGLTLNLPTLAVTTETPFGELNESQQIAISHALKQAFTVIQGPPGTGKTIVGAKLTSLFVERNKCLTCCAKTPHVLYCGPSNESVNVVAGYLKRFHNLRVVRVYSETIERQKFPIPGDPVEICQNRTGQENKMDSRLDDIALHNLIRRPSNTHSEKIKEFDQLFSQPKYKASQDKIWQYRKEVAKAEEEELSKYEVILCTCNAAGSRRIRDNANVVQCIIDEAGMCSEPETLIPLVATGPEQIVLIGDHKQLRPIIKSKLAEDLGMGISMLENCKDSVHMLTTQYRMHESICKFPSDTFYKSRLETAEAVKQRRPELRGQHIWPGGPTFRNVFCHVQGREETLTVKAAEGNEMSKANPAEVEQVVKIVTSLILQCKIKGKRILVLSQYRLQCAKIKEKIREAIAKQKKYHLRRELKNVTVSTVITSQGGERDYVVFSTVRSLPRQEIEDKPTLGWKHRHLGFIMDDNQINVALTRARNGLIIVGNQRLLQVHSTLKELLDYYRRNGAVLNAHTFLRRMITDNQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZPB3</accession>
    <name>A0A8B7ZPB3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Somatostatin receptor type 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110988237</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022107259.1">
        <property type="nucleotide sequence ID" value="XM_022251567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZPB3"/>
    <dbReference type="GeneID" id="110988237"/>
    <dbReference type="KEGG" id="aplc:110988237"/>
    <dbReference type="OMA" id="VACYAYA"/>
    <dbReference type="OrthoDB" id="9818824at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042923">
        <property type="term" value="F:neuropeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229:SF40">
        <property type="entry name" value="ALLATOSTATIN C RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24229">
        <property type="entry name" value="NEUROPEPTIDES RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="47"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022107259.1"/>
        </source>
    </evidence>
    <sequence length="389" mass="42587" checksum="50428122BD015B34" modified="2022-01-19" version="1">MGENITKDGAPSPTTLPTIPVLYLREQPLRYVAPSVMALTLVVGVFGNASLLYVNLRALRGGKSQAVLDVFLASLAAVDLLLLITTGPFFAAEFVLEDWPFGSPACRFLLPFNHMTETVGACTVGVLALDECLVIALPNSYAPRRDLGKSVVANLMIWLSAVILTIPVSVNTKSTQTLYHSSFCTVSMPGPTLVIQLYTFIVSFCVPVVFTLGCLLWILYKSNGNFWRPAKDESQPRSKQTRTTVLLIASLICAQALLWLPHHVISFLQPGIHSEATTRGDFLSHTTVACYAYAYSAVKPLLYVFLSGDIRDRFVEAIPFGKGSDVRGIGRGRRLPTSPNRYLSERGSKAGKGPSVTTSMHTVHGYPYIVEVDGEDRIVMNGLDRRWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQA1</accession>
    <name>A0A8B7ZQA1_ACAPL</name>
    <protein>
        <submittedName>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
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    </evidence>
    <sequence length="3382" mass="369805" checksum="C631E53C148D66D8" modified="2022-01-19" version="1">MAAILFDKRSKLRCMSDMAVSSYDQLLAQVNSLKAENSHLKKELKENSCQLTKLETEASCMKDALTQIQTSMQEEEAAAAETAMATSLDHNSNNGFSPLTSPLSPNAVRTHKPHSPPNSQSSSGSLAPEMPGSPSPVRQLQENMARMQELERERILLLTEQDNEEKLKTWYFAQLQSLKQRIDQLPITENYSLQADMSRRQLEYEARQLREAMQQRLGAADDIGERHEARMQRLCLIEREMQRLQQRRERLEREAQENSGHGSSKDSHSSPLNEPNANDPLQRCSNSPKPGSSAHHTPETKPKDPKHLLSHLPNGMNPAALTGAVGSAESDSPYAHLSADGSVQQATGGIEGPGGVSPSIPPTMLHGTWPYVGGAMAIHQRHVIKSTVNATSSSSEQETSSVMSFSSSACSSGPGRRLQPGQLGAKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCIAMRQSGCLPLLIQLLHGPDKDSLLGDTRGGKEARARAAAALHNIVHSHPEERCRKQEARVLRLLEQIRAYCDSLREADGEEGSKANAVDTNPGPAMAALMKLSFDEEHRSAICQLGGLHAIADLLQVDYESNGNTSDQYAITVRRYAGMALTNLTFGDAANKALLCSMKGCMQALVLQLASENEDLRQVAASVIRNLSWRADLASKKILREVGAVVGLMKCALEVKKESTLKSALSALWNLSAHFTENKADICAVEGALEFLVATLTYKSPSRTWAVVENGGGILRNISSHVATNEVYRQVLRDHNCMQVLLRHLKSSSLTIVSNACGTLWNLSARNKHDQDLLWELGAVSMLKNLVHSKHKMIAMGSSAALRNLMSARPDLLNATESHKEGQPTLHVRKQRALEAEIDKNLRETYVSMEKDCHAMQRRMPVRSQHRSPQSSADYSPVPQRIAIWNPQQSPTHELILSQHRERSQSPTSRQVNCRDAPHPRDQDPRKLSGRSPGLDGEHSRAEDSSQHHSGTGSLESTHKRHIGGSSRIAQVMQEVAMHAGIDMSSSSQEPHLYLDQQTQDNIEREAPSSVELPPDDRCEPSSHSNSSYNAFGFGGYNMNARRASNDSINSINSDIYPMGTHTKLPYAKQPMDHSHSMDGTLNNALDQHQRQHKAIFQRVNHEDLGANMDSTINFSLKYSDESLTPAPRPCPREENYQPKPSLECGHYKQGICGEKRVIESCPQQGDDNQPQPVVLCQECNTPHMQREGMAVGHTFVPPPETERIPGNYPSSYSNPPAVQRKLMPMKDPCSLDFGGNMEDEKPIDYSRHNLPHSGHLRSRFNEDDHEHYVSDQPTDFTQRYNTDLPESTTEGINFVQTSLTTGTTGNIFMNNNEKQEGPLGNMPDGSSSRDNSSEGQLDLLRSDSVDTSTSLSSTHTAISRANDDKKQRYCVEDTPVVFSRCSSLSSLDSNEADHHLDHQEEDGIHSKQDNEGHPKDSECDEQDGDQRRENQQEGTGNEPIESGLQTPASMNQIQDTPLIFSRCSSVSSLSSFEVQSICDDHSSCYSDSRRASEVVSPSDLPDSPSQTMPPSPRRGRKQVSAQTSSCDPETVGVLPECEENLVTYATEGTPADFSCATSLSGLTIDDEEKAIVTSNIQDEGDTMDLLDSKNEVKESEVESGDISEREQNMLDECINSAMPPKKSTLSSKPNKIRSHNAVNVHSVKSPQQNGKHVSFSQQVCSQEAPNSYATEDTPINFSTATSLSDLSIEDIDIQATKEGKLKVNNPLSSSEASLDGQNAATTKQSTVVPGAQGDEMKSESSSLINDAEDSMLEECINSAMPKAHLNKSRSSQLSKHRSAKGMSKLRSPKPSGLPRKRLPSAGVRHKSPSPIPEMGSEYQNATSSQERVQQWQNGFGGTTDSVRTFCTEGTPQQFSTATSLSGLSMDSHNQEDVLNGNVTAQVDKSEPSEMKRRQITSGSSHIDSPRQYAVEGTPMSFSRNDSLSSLSCDDDVDLSKEKMILKDKMQKHKADGATSVQNKQSTSTRSLSKLPQPSSRIAQLRRRSEKQTSVGGKPQNLRELQSRQMVSNTSSSYDSPQVFNLEGTPVSFSRNDSLSSLSCEEDADLHNDKRSLRESKESKPKVNTQSKEGRAQKRTEECSQREYLRFGQSGSKPIQVNNQDHNSERPNSTETPVKFAVEDTPVCFSRNSSLSSLSDHDQGETQHEEESPQPEPSHTSVFAVEDTPICFSRNSSLSSLSVESLDGETSIGEQALLDECISSAMPRSQGKKTKRRHHKASRTRETRETEEREKYESGSDNPTNDLEDNQFSPLSPSEDASNEFSEITEQCQDEDKPHRGPRITKPGEPGSRIQSETPEKGVRGGRKTYKSPISNTSRSVSVPKNIQPNKYQATRAGAQKGSQVNSAASKNSVTGVKGTTPNRSGNSTPVRSSTPVRTTTAQREASPKGSSSSKPPPINTDTFTKKKNLTPGSAATARSVTSQPKSTMPTGTATKSLANKQANSKSVAQGVATKASQLSKDANRTTPSTRSNLSQKNSPNSSRNTSPCSPTSRSPRGSISGPTSRSTAQTAKSSSLSPARSPMSSRTSSPSPHSTASTRKPLNGTPKNGAPGRGSGASTSPSPRSGLPSRSLSPRNSVTGTSQKSTSPRSSISGAGTRNASPRSNVSGLGSKNTSPRSSVSETSARSVSPRNSISGIQARSVSPRNKTLTKAPVKKTNNAPAPADKKTTGTGTKTNRPKSSNVYRLEVGSSRPTLVKQSTFTKESASLPEQTPENTMGVESEAEKVIEENDENEGSVENDVFTMDDQENDSEEEKEESEPLAPSSSWRRISVESDTQQSVLEKTQRPSGSPKTQSSGSASKTPPTSKKMALNLVKPGTKTVSSGNTPNTAKAAVKNSPALSQKCKREQLEAKPSWNSSVTAPKNWGRSSSPANSRPESPAISKNQSQSPSLNKTKSPSPGIQRVKSQERETDELSKRSPKTTSETTRDLCKELDIPVKNYGGNVTSPVSDSSDNSIWIKREESTRRTNIIIRQNSSSVSLQSQNSQSGSARSVKSSNSATMSSSSASARNANVTDKPSGQGAKPVTSGKQGKEKDSTEKKVEKKKFSFLKLKVKGKKPEAEETKTKSKGDKQLRDQKRKTSKAPAHTMSPESDVTSPENDLEALNLEHQLDQLDVWNSDDNIDNEIMPDEFIEWDSETDIFKEELPDEYLLESGSDVTSSLTSPDSPCKGAYQIEKGNRTDDSPSPEFKQFRLENRLNSFIRMDCSEKECDSDSTRSAPVVGEAKNCRSKSVSDAYPAYSSGDQSPPRPQRLRLPKKPFGINRSDSSPTAAIPVLVSPFNYSPSKRSQSEPHSPDMARRRFQSHHSYSFHESREHRQRFKQYKQQQQQAPQEEYVCNSEDSDLISPTLSSRVTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQN2</accession>
    <name>A0A8B7ZQN2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein MTO1 homolog, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110988314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107377.1">
        <property type="nucleotide sequence ID" value="XM_022251685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQN2"/>
    <dbReference type="GeneID" id="110988314"/>
    <dbReference type="KEGG" id="aplc:110988314"/>
    <dbReference type="CTD" id="25821"/>
    <dbReference type="OMA" id="CNPAMGG"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000082">
        <property type="entry name" value="protein MTO1 homolog, mitochondrial isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="5">
        <location>
            <begin position="603"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022107377.1"/>
        </source>
    </evidence>
    <sequence length="685" mass="75964" checksum="82DCBEC3BBF89D6C" modified="2022-01-19" version="1">MMSCHTARLRCRLSFLKTRKLLEHLQQWHRSITKGSDGASRSPSQCHYDVVVVGGGHAGCEAAAAAARTGAQTLLLTHKIETIGEMSCNPSFGGIGKGHLMREVDALDGLCARIADKSGIQFKVLNRRKGPAVWGLRAQVDRDLYRKHMQEEILNTPNLTVKASPVEDLIIGDVQAEREDTIAQKGCYGVILKDGSRVSSKAVVLTTGTFLRGVIQIGLDERPAGRLNDEPTIGLAKTLESAGFTLGRLKTGTPPRLDGRTIDYSQLERHHGDATPIPFSFMNDRVTVKPEDQVICHLTHTTPGIGPIIVENKHLNVHIKETVSGPRYCPSIESKIFRFGPDRLHQIWLEPEGLNTDTVYMQGFSITLPADLQDQCVHMVRGLENVVMTRPGYGVEYDFMDPRQIKSTLETKRLQNLFFAGQINGTTGYEEAAAQGIIAGLNAALLVRNQTLFTVSRTEGYIGVLIDDLITQGTSEPYRMFTSRSEFRMTLRPDNADQRLTSRGFEAGCVNLERYQRAQATADRLDEGMEVLRSVRLSRSKWRQGMEELKVETPLADTIPGKISALEMLAYRNVTLEHLAAVAPDLKKYADDENVAMRLKIKGVYAPLLHQQQCDIDQVKQDESLVLPADIDYDSLNMSREAIAKLSAVRPQTIAAASRIEGMTPAAVLRLLHHIKRREKQSATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZR48</accession>
    <name>A0A8B7ZR48_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Deleted in malignant brain tumors 1 protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110988400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107542.1">
        <property type="nucleotide sequence ID" value="XM_022251850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZR48"/>
    <dbReference type="GeneID" id="110988400"/>
    <dbReference type="KEGG" id="aplc:110988400"/>
    <dbReference type="OMA" id="VECTHIL"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000006">
        <property type="entry name" value="neurotrypsin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000007">
        <property type="entry name" value="Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071:SF18">
        <property type="entry name" value="DELETED IN MALIGNANT BRAIN TUMORS 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48071">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034707752" evidence="11">
        <location>
            <begin position="22"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="30"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="143"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="253"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="361"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="475"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="12">
        <location>
            <begin position="591"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022107542.1"/>
        </source>
    </evidence>
    <sequence length="720" mass="79320" checksum="6A6BBBFF55916695" modified="2022-01-19" version="1">MHFMFLVTTLVMTVAVNESSAFKTSADNTLRLLGGATRCSGQVQVYLGEWLNVYRTHWGVAEGRVVCRQLGCGELVSPYANYKDKAQADPVWNELVSCAGDEATLMNCSHSRNASDMLGPEMYRAAVACHQDDITSAPESMSLRLVHGTAPHSGRVEVYYNGEWGTICGMSGWSMTDGHVICRQLGYTRAVAVKRYSDPFGPGNGTILMSFVDCDGHEEKLGNCRHQGWYQHNCDHYNDAGVICKASSNETGIRLADGTTQYEGRVELFYNGEWGTICDDGWGIEDARVVCRQLGFGPAITVGSGYGQGQGAILQSDVGCRGMETSILDCDLQKWYPSTHCHHREDAGVQCHEPENPSVRVRLASRLLESEGRVEVYHNGEWGSVCGYSFTLREADVFCRQLDYRKALKVLEPGWYGDADLIILDNVQCNRSAKTLEDCQGLVWYPKHSDCSLHETAGVMCDSNMIPDTVSSVEVRLTGGSMEKEGQVELYHNGQWGTVCASGFDLKAAQVVCRQLGYYNALYRTSGETFSDGSRPLLLDRVDCRTGLEKNLARCGPLEWYRHDWQNCGPEETAAVACHGSKIGGDIEIVVRLSNGTQASNGRVEVYHRGSWGSVCGAGLGRSEAQVVCRQLGYEGGEPVEQFGFYGSGKEPVSMWGLECTGEEELVEQCRSIQWYNAQKHVCDRELTAGVTCLLRGGRNILTSFSDRSCYSVECTHILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSA0</accession>
    <name>A0A8B7ZSA0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase LRSAM1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107745.1">
        <property type="nucleotide sequence ID" value="XM_022252053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSA0"/>
    <dbReference type="GeneID" id="110988495"/>
    <dbReference type="KEGG" id="aplc:110988495"/>
    <dbReference type="CTD" id="90678"/>
    <dbReference type="OMA" id="LWCSSEC"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16515">
        <property type="entry name" value="RING-HC_LRSAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF47">
        <property type="entry name" value="LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="578"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="689"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="244"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="483"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022107745.1"/>
        </source>
    </evidence>
    <sequence length="743" mass="85011" checksum="E50F73D0939B5019" modified="2022-01-19" version="1">MNPDNSIHQINMPKLLHRQSESARKRMEHCQYLATESPEPTYDLSRCEISEVPSGTFSMCKVLRKEALILSENFLSSLSGGGNIKDLAMLRVLDLHGNKFSEIPDAVTDISGLQVLALDNNNLKKLPRDIGKLQALQTLSVKGNQLKELPGSIVQMKSLRSLDISVNKIKELPSKLCYIRTLETLTLDANNMKHPLASVCIRGIEAIMKSLCGECGIDYSPPSQHVLSVLDPPKISPVTDKPSLQSLEQEEASLSNSIMQYEKLQGKKRLERVRMEKELEEMERDQARLMIQTDQRHMGLLKALEKEQADLDSGIKTLQERSDIEKQNLLAMLHDVEKQSTDLVEQLLEMNEKARKKEALLDQLEKERMELDATFSVIAEEHDFLRERDILDFMQVIVKENYELEQLRNTYDKHKENIRKKAEDSENEAFDQLSSHLQAKQLNNDAMVAELMKAEEFQRQAFEMLLLSKDAKHKRLTEEIYMLQQQLAEVTMAELEKRSVKAESANITLEQKREELAALLKQLMIEREDREEELKKRLLEMEQRREDDVQDYWLIQFQRLMDRKPQALIDQENHLELSVLEILERAGADDYIPKFARHRVTIETMLQLTDSNLKEMGVHELGLRHAILSHISEFIKEREMASVKAKEIESNETVPRMNPTAPFMDEDSASAVAAATVMKEVTVRVNAECVICMENNSDVLFLNCGHVCCCGSCSGSLRLCPLCRSDIHTKINMQKSSQSLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTV0</accession>
    <name>A0A8B7ZTV0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SCO-spondin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110988744</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108235.1">
        <property type="nucleotide sequence ID" value="XM_022252543.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988744"/>
    <dbReference type="KEGG" id="aplc:110988744"/>
    <dbReference type="OMA" id="EHTSTYR"/>
    <dbReference type="OrthoDB" id="160294at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000055">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF386">
        <property type="entry name" value="HEMOLECTIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00214">
        <property type="entry name" value="VWC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034305187" evidence="6">
        <location>
            <begin position="26"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="8">
        <location>
            <begin position="253"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="8">
        <location>
            <begin position="621"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="8">
        <location>
            <begin position="1085"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="1483"/>
            <end position="1498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022108235.1"/>
        </source>
    </evidence>
    <sequence length="1725" mass="190547" checksum="A4DA9956EDFCC26B" modified="2022-01-19" version="1">MAILPPQYFLVLLLLTHFCPRTTRCQVAESHFCNREKAIDVIVEEKYLAEEWQTLEIPLQGYKDRLSRGDNVRLLRRDDASGMCQVQVLQTVERTRPRHQTRLRVVRDCCQGWLGDNCNIPICEPECVNGQCIFPPDICHCSPGYTGPTCETPVCDPSCMFGECTSPDHCECSTGFSGPTCDKAVCEHGCLYGDCISPNLCKCDDGYEGLSCENAICNPECVSGVCVAPDECHCHPGFSGKLCEKGPVANKEHKCKLCCGGAFVSFDGYYYTFPTAGLFNLASCDDCGIGAFSVRVDASYPCNEETCHIYNKVIISYRVGSRDFTVELLPQHGVRYENQDVTDLPLITDFGTVSKIGVHTVFKGFQGNDVIVRVDTSGSIDLRVSDLFRGSMNGMCGNFDSDAGDDDVSTEVAQGFGMSSEAIDPLDPCNLGQNEQLADAAYIICSEMLAGVLDGFRACFRSVKPARYHEMCLFSMCQCLRLVGDAAPGPCFTEGRKAILCDVLTQYSRDCTAEGVLPNWRREDLCPVHCDNGMVYTECGSPCPRTCENLDFQEECEQYCVDGCHCPAGTFWDRTKCVSREECPCPRGSDMIPAGNAITSGCKLCTCLGGRWDCTTNECNATCSVSGGHHFKTFDGSNYLFPASGSCEYLLAELTDPNFSILVEFEDCSASLRSCLMIVSIVTADQSIYELNSQSSIKASTQSGTTSHKLPFRVESADGSTLVARQVSSIFTRLTIAEHGIDVLLGRDGRLYLTLNPKWQTKVHGLCGTYNSKQIDDFTALSGVDAKAKINFFGNSWKMGRHCPDVEEDAALRPCDLHSQRVHLANRICKMLRQPPFNECNKLVPVDKYEEQCRDAVCGCHASDNQCQCLAFASYARECVAAGDKFHWRSAQFCPVKCPSGEVYKICGSNCVSSCGDISSDQFCQEECVEGCQCPEGRIRDVGSGQCVPVEDCSCEVDGVVYGSRQSWRRGCNECYCSAGTYRCTEKDCTAYESCADGMEWLLCQECERTCQNAYLPCVQTICTPGCGCPEGKVLHKGTCIQVEECSCDYNGKSYKVYEKVAMDCHECMCNTDHRWICDDDTCPSTCSSYGDSHFVTFDMRRYKFQGDCEYTLVEDFCGEPEGSFRVLIENIPCGENGVTCTKAIKFTLYDTTIYLVRGRPYTVTVNSEIDTKARIKMEDAGMYLVIKTPDGITLKWDYGTSVHVTLDPLLAGQVCGLCGDFNGDANDDFKTRNREIEAMGHSFGHSWRTVANCAEPREVLYPCDSMPHRRPWAEKVCGIIKKSLFSSCHNLVDPEPYFLACVFDTCACDRGADCECMCTAIAAYAMACNENNVAMAWRSDGYCALQCENGRKYQACGKICPDKCYPSHASEDYGCETHCVEGCHCPEGQVLFRDKCIERQLCPCFIDNGRVQIKHGALVVRDCMQCMCNGGHLECSGTNCTQRAVIATKKPCAHKPPPTCTCPPGFSCCADQTFCIQDTKFCDGELNCKDSSDELQCDCEYKGIIRSSGDTWSGEGRCEVCRCEAGRTRCFKECNILCDALTEVLLLNEHDDTQCCQCKKISIPTTASPVTTTATSECEEGTTVQPDECRTCDCIDGTYSCYYDCHKRPNSCAEGEQLVSFEDKCCECVSITTTLPSMMTTPTVECLDPFVVGEPTCCQYMYLDTCEIPPTFSGSETCNACKRHLVFNGTHCVFPNDCLCQDVEGVHQVGFNLDTKPIYWIIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUI1</accession>
    <name>A0A8B7ZUI1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="34">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="34">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="37" type="primary">LOC110989004</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 33 34">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 33 34">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="34"/>
    <dbReference type="RefSeq" id="XP_022108747.1">
        <property type="nucleotide sequence ID" value="XM_022253055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUI1"/>
    <dbReference type="GeneID" id="110989004"/>
    <dbReference type="KEGG" id="aplc:110989004"/>
    <dbReference type="OMA" id="HAENGHW"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000159">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 33" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 33 34" id="KW-0274">FAD</keyword>
    <keyword evidence="7 33 34" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 33 35" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15 33 34" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 33" id="KW-0521">NADP</keyword>
    <keyword evidence="14 33 34" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 35" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 35" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="35">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="RefSeq" id="XP_022108747.1"/>
        </source>
    </evidence>
    <sequence length="530" mass="60094" checksum="F79FDFD5C431F4A1" modified="2022-01-19" version="1">MSKRVAVIGAGISGIAAIKCCLDEGLQVTCFERSDRIGGLWAYREDRDGQGCVFKSTIINTSKEMTCYSDYPIPKEYPNYMHHSYIEKYFLSYVDHFDLKRHIQFRTEVQKVAQAADYDTTGRWQVTTKNRDSSECTTDLFDAVMICTGHHTTPHIPDFPGLKDFQGTVTHTHEYKTPYHLIDKRVVVIGIGNSGGDAAVELSRISSKVFLSTRTGAWIFNRVNLLGNPFDIVFTRRCIDALPLTLKNAITKRQMQINFDHSKYGMRPKHNPFQAHPLVSDDLPNRILSGTVTLKPNVARFTKTGVEFVDGTFEDDIDCVILATGYTFSFPFVDCPSFQVVKNDVSLYKYVFPTDLKHPTICTIGLVQPIGAIHPASELQCRWAARIFNGQARLPPRPEMEASVKKAKDDMSKRYIKSQRHTIQVDWIKYMDSIAVEIGVKPDLWKLFWSDPALALRCFFGPCLPYQYRLMGPGKWNGAKDAINTMWERVDAPLKTRLPAVREDRSGAAIILLWLGLAFLLIYLVILIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZW34</accession>
    <name>A0A8B7ZW34_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21 22">Uncharacterized protein LOC110989137</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21 22" type="primary">LOC110989137</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108975.1">
        <property type="nucleotide sequence ID" value="XM_022253283.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022108976.1">
        <property type="nucleotide sequence ID" value="XM_022253284.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110989137"/>
    <dbReference type="KEGG" id="aplc:110989137"/>
    <dbReference type="OMA" id="VEWDGHH"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22823">
        <property type="entry name" value="Gal_Rha_Lectin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd22827">
        <property type="entry name" value="Gal_Rha_Lectin_SUL-I-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000055">
        <property type="entry name" value="alpha-tectorin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000095">
        <property type="entry name" value="Notch, isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000391">
        <property type="entry name" value="Weary, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.740">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000922">
        <property type="entry name" value="Lectin_gal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043159">
        <property type="entry name" value="Lectin_gal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339">
        <property type="entry name" value="EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11339:SF373">
        <property type="entry name" value="VWFD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08742">
        <property type="entry name" value="C8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02140">
        <property type="entry name" value="SUEL_Lectin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01826">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00094">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00832">
        <property type="entry name" value="C8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00216">
        <property type="entry name" value="VWD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57567">
        <property type="entry name" value="Serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50228">
        <property type="entry name" value="SUEL_LECTIN"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51233">
        <property type="entry name" value="VWFD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665759" evidence="14">
        <location>
            <begin position="30"/>
            <end position="3748"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="17">
        <location>
            <begin position="38"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="17">
        <location>
            <begin position="146"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="19">
        <location>
            <begin position="824"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="1490"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="18">
        <location>
            <begin position="1532"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="15">
        <location>
            <begin position="1956"/>
            <end position="2106"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="15">
        <location>
            <begin position="2277"/>
            <end position="2456"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="2457"/>
            <end position="2497"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="18">
        <location>
            <begin position="2501"/>
            <end position="2663"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="17">
        <location>
            <begin position="2892"/>
            <end position="2980"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="17">
        <location>
            <begin position="2996"/>
            <end position="3085"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="3095"/>
            <end position="3133"/>
        </location>
    </feature>
    <feature type="domain" description="VWFD" evidence="18">
        <location>
            <begin position="3137"/>
            <end position="3315"/>
        </location>
    </feature>
    <feature type="domain" description="SUEL-type lectin" evidence="17">
        <location>
            <begin position="3649"/>
            <end position="3743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="240"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1499"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="1518"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="2487"/>
            <end position="2496"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="3104"/>
            <end position="3121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="3123"/>
            <end position="3132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022108975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022108976.1"/>
        </source>
    </evidence>
    <sequence length="3748" mass="414014" checksum="BF6BEED84CCFA1E2" modified="2022-01-19" version="1">MMPPDKSRLKPSTFLLAAVLIALARTTAGFVNMQIKYACEGEILRLDCGEKFIKVWSALYGRANPTICQEDLMAPLPAPCRADKSNFETIRHCDGNHTCEVQAANSVFGEACDSIKKYLQVEYYCRSETPSECNPRDSPTYNTKYACDGTDLVLECPNPGEVIKILDANYGRQGSDVNCTYRPGIDDIFCDDDTGESFEHVCLECRGKDECTVPVGPQEFKDRCLNTNKYLSVQYVCVSTDAEEEDEEDERDTPQGSELPEEEQPRPERPGPNGNPAVETTSAPRPRGPQIFSLLKPGQAISASGSIGVSQGESGSKSFIWNGGLPAPKPGKITAQGSISSTRPDGTERSFTWGGEPFEGFASLFRPVGVSPGSTQVIMKIIVKTDSNGQKYFTWQPLSPGEPSGGAEYLMKIDLSKLTQYTEQFTFAQLIEDFNKGLTFYNMYNKPSDITPPFQFSIGKGLTAFFPSIYQLITEVDATTGKTVTVPSPSSSSFQVLLDGGNRQIIDYLLTFANMNQQLRSELQDYNLRIPLRFYDETTKQIQDIKIPFYVSYNGFEGTLSSVFNVMPKPSTQFGMKFQIVGEGGNTQLITLPFTLIEYQGRKMLFLTLPTCAAYKMYGFVDDKEYLIDPDGVNKGEQPFVVQCDMDKGETIINHNRKESTVATYPAGEDRADVDITYDGASPAQLAALRTVSETCEQELSHECIQKSVHFVGGDARIWWESLDGTKRDNWGGVDTGVSKCHCGLTNACFIKGSACNCDHGQGTSDWGALTDKDTLPVRRVVFKKPAAQQGQDKLKVGPLKCSGDLSSNTLQFFIVLMQMLARDPRGKILKTCDDYKKIGYELDGVYLIDPDGGGGEKPFTVHCDMQSQEYGVTLIHHELSNERTMVNNFEEPGSYSMDIHYGATLRQIENLKAVSGVCEQSLTYECQRSAFRVGGVQYHWWMSFDDEKTDPTCLANNNCVCDKDDGVLRKDVDVLKDKSKLPVMQLRYGDTGGSDELGYYTLGPLRCWKDSGKTVATRMELSSCDAIKRADPAARSGNYYIKPYANMDRFYVYCDMSGTEGVTVVYPDAVRTLDIDGFYEEPGTWARAVRYGPSQAQLQALTTLAASCKQFISHGCHGSLHNDDVTGKVYTWWQSRRGEKMTYWGDTKEGCQCFADKSCHDPSKKCNCDVNAQSLSSDEGYLTDKSALPVSAVRSGDVSDNNGWEYGTVKLGPLMCQGEQASSESREISTDQECESVTTADGEIYRKINEEQTFSNFDFSVQTVGTAILKLGVYSGSASAYYKIEIESGNHVNFYRCNYNAQREDCGTPQTQSFTSSPPGSSVPRNFTLNFVSPKLELTLGGESLTFTDGSLRGLNVRYFAHKTVGGDGKWIFDSICMGNVKVFCSRIGKVTCPAPMKPYVLKALYGRMEKDVCPMANDPTDYPDCLLDVTKKLQRLKHSYCVNGDHTCLYPVYDSFYASALSKASCRPKNGYLHLVYACRAQAPQERALGPCSSDPCQNGGTCDDSSDGLSYACQCHESFSGEHCETEMVLCRGLGDPHYRNFAGHTFDFQGNCTYVFARDCKEDPDFEVHVVNQSPLFNMAVSSTVEVILVFDGRTILLKQAREVLIDGERQDSLERLEEDFTLTEQGLKVVVHVPKYSLTVIWNHKDIVDVRLPRNSGGDVCGLCGNTRVFQPMGSYQMKSGTVVQDPVVFGNSWQVDVGTCEANTHPNNWAQLGHSLSSSQLIIAQRFCKFISQALVSGCPITAATADFRRQSCELDHGSGLRDKACSIINDFRDECTGEGGTVSESTNTQCSTECASHLNHTQCVMPCSTCSSLRLSPGSCQGACAAGCTCPDGKLDDGDSCVDEDNCGCEHEGRYYKLGSTFMDITCTEECTCQGGNVVQCGPPSNRLCPVYQTEFLTTCTLHDGVYECTCISGYAPNADGTACQAMPMDVIVRPPGRRRRRDVSLDECNVDLGMASGRIADNQISSSSSKDASSLAKHARPTLGGWTAQRSDTDQWLMVDVAVPTEITGVTTLGSRQKVHGRYKQAWVSAYGVDVRLDSMDPWTAMRDTKGSEQFYGNRDTNTPVTNMFAEPMRARYVRIKPISFYGEITMRLEVKGCKQLCDAEIGSFPVKRHVTSDNWFVVNAGDPINCMGHVVAWKVIHAREEPLEAWVLRPLKSEPNGFTLIGSTHIPAGPVDKEMEYELNDQQQIPVHTGDVIGFLYERNPLYSSEDGEETTDYEWLHIRDISNYETMKPGLSLRFNGGQGKRAFSAVAVLQSSNGVPVPPAQCMGEMGLSMDKMSIPDESFSASSHVKGHTPARGRLNTLYSQTGMRSGWTPRRRDRRPYLQVDLGEQRHLSGIITQGRHSKHDWRSVVQQYLGQKWGRRRRRPFRRQAWLIAYFVKHSLDCEHWDFVRMPNGQRQLFEGNVNPSTPRTNYLDRPVTARCIRIQPKRQRGLKIGLRLELLGCSIDPCTSSPCEQGGTCKQTSGLDADGFVCQCPPGWTGSRCEIVEGSCRSAGDSHYHTFDGRHFYFPGECTYTLAKDCANGETPTFDILTNNAAAGREIYIFTNNIMFEFKQEGVVHVDGEACELPVKRNGVSVVHNAYTGVLLQTTYGFTVEWDGHHRVIVNLPESYANAVCGLCGNFNSDKEDDIPQDVSEMQYGETFAVDPENCEVCQKCLLDKPYILNPGKQAEANELCNPIKDPLGPFARCHGVVSPDEIYDDCLQDVSDSDSLSSVPRCTQFAEYADVCAENGVVITSWREKGLCGITCPAGMIYTHCGSACPATCGDPHAPKTCTRPCEETCQCPEGLLKEGDKLCVVPSECGCTDNGCYFERGTTFYRTGCTERGMCGLNGEVTYLPGQCGQNATCGSKDGVYGCFCSDGFSGDGQQCTNIQDDKALLTCESEVLRIDCGPGKYIDIVEAVYGRNEDFEKCPTQAQPKGECSAPSAMSALVAKCQGREDCSVDVTSEVFGDPCYGVSKYLEVDLQCTATPKPKSVSEEIMKRVCQGDSMEIDCGDLYIEVVDAVYGRLTDGQVCPGGHVESVDCTAQTSLKVVQELCHGEHRCTGLQAANHVFGSNPCGRTFKYLEVKYKCSSSAVPKADLPANACAKNPCQHGGQCVTVETSRGYKCSCPHDWTGPNCEFEEVSCRASGVSHIVDFSEQHFEFLGDSKYDFASSCPENKYDFSVMIKKARVPTENSVSAIEAVHVHYDGKIIELKQEYVVLLDGKKVSDTLNLNFGKIKLCRVGNYLLLKTDFEMIVAWDGLHRVQVRMPDSVAKQTCGLCGTYRGLSTESPGFIDRDGNKVDDMNAFGSSWRVASDAPSFVHTNLINLHPCVVWPRRAYAAAGLCSELKNVRGVFRSCFGKVNPEEYYRKCMYDMCATLPSQEFLCQALAEYADICLDEGIVIDNWRASYRGGQCAMACPNGQMYSACVQSCPKSCGDPYAEREPMDRCYEGCACRDNGHFQDADQCLTSANCGCRRLGVYHQPEERVVNEHCTGQFICLPGGEWSENPLTCDVNAHCGVVDYKQTCLCNDKYAGSGKQCFDAQNVVMKVVSQGESLHIDCGDLFVDLLSADYSFSDPSSAGATTDPDCHAPNVMGILSNHISQGGRVLEVKASAYHLGETCRQTDNVLTVGYICSAQPALREEGLGHVVSMRGCQDREIALKCRKGSRIRILKAEYGRQTGSEVCQSAYNKYILTTSCRAPAKRLEKRVRRRCENREECRIQIKKRKLRVNPCKETPKYLDITYKCEAFEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXN5</accession>
    <name>A0A8B7ZXN5_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110988793</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Putative Notch ligand involved in the mediation of Notch signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022108316.1">
        <property type="nucleotide sequence ID" value="XM_022252624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXN5"/>
    <dbReference type="GeneID" id="110988793"/>
    <dbReference type="KEGG" id="aplc:110988793"/>
    <dbReference type="OMA" id="QNGHYRC"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048592">
        <property type="term" value="P:eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051093">
        <property type="term" value="P:negative regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051241">
        <property type="term" value="P:negative regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003002">
        <property type="term" value="P:regionalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000117">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.140:FF:000001">
        <property type="entry name" value="Delta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000279">
        <property type="entry name" value="Neurogenic locus notch 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000031">
        <property type="entry name" value="neurogenic locus notch homolog protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000109">
        <property type="entry name" value="Notch homolog 4, [Drosophila]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000565">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000122">
        <property type="entry name" value="Protein crumbs homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000309">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000472">
        <property type="entry name" value="Uncharacterized protein, isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001774">
        <property type="entry name" value="DSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051355">
        <property type="entry name" value="Notch/Slit_guidance"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836:SF13">
        <property type="entry name" value="PROTEIN CRUMBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45836">
        <property type="entry name" value="SLIT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01414">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12661">
        <property type="entry name" value="hEGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51051">
        <property type="entry name" value="DSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 16" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12 14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 14 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="806"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="DSL" evidence="19">
        <location>
            <begin position="191"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="239"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="276"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="352"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="390"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="428"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="492"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="530"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="567"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="604"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="642"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="555"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU280815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022108316.1"/>
        </source>
    </evidence>
    <sequence length="939" mass="103451" checksum="33C6CEC7C623E804" modified="2022-01-19" version="1">MVSGEHYNQQLLTAVELKPRMKLVLILTTLSQIFLLAQSTATVQFKFVSFKNDDHNDLNGGCCDDIIGGCDDFCDNYFLVCIDRDDTGSDGSSCDMARISTERIYEDNDDFNFPSTIPNGIANPHTMSVTSWPGGMQVFAHVWDLDPVGAHDEVDRARRTIDQPAARRSFSAVWQEYTLGQQTEFRFQVKVYCDDHYHGSDCSVQCVPTDDQNGHYRCDPVTGAKICYSGWEGPNCNLDYDECQSNPCVNGVCVNGANRFSCTCTNGWTGTNCDINVDECASMPCKNGGTCHDHVASFSCSCPPGYVYADQFCEYDDCASQPCQNGATCNDLIGHFQCVCLQGYFGDLCEVDIDYCINQTCANNGTCVDQLDGFHCLCEEGFEGVMCEVETDECTSNPCLHNGTCIDLIGKYQCTCEEGYEGTDCEQETDECLSFPCKNNATCEDELAGYHCHCSAGFEGDACENDMDECASFPCHANETCVDDINGFWCQRMNLCDSDPCLNNATCVNDYPGFICECTAGYDGKTCDDDINECASSPCLRGTCVDRLNGFSCLCPPGYSGYTCKSETDECNSSPCVNGLCWDLINSYVCNCTAGFKGVLCEDETDECSSSPCTYGTCVDDLNAYRCECDEFHTGRNCDAAIDDPCALTPCKNGKCETIDSAIDNNYNCICYNDFYGKNCDVDLKQHGAVVFVTGTLDSESEFASRLASLLQKLYSLRLWNTRNDERETMSVEVVRTEDYVKSVDSSLLTRVTFIAWTESGHLLDKVTIEGLIKGASPELIGEFGFDIYYGSAEPYTGKTWIGSNWYIFVVVLAVISFFAVGLLAYRRGYVVQIKDAFSERVRDRGQSALDPLDVAYSTRIFSEFPSSMHHQVNTVESINPAYISCSDEKDHAFMSGSSDEFLGATGGAHESTDNIYAEIPALKCEAAAKENPYSDVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYH8</accession>
    <name>A0A8B7ZYH8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex protein 3 homolog</fullName>
            <shortName evidence="5">NOC3 protein homolog</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110990015</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110469.1">
        <property type="nucleotide sequence ID" value="XM_022254777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYH8"/>
    <dbReference type="GeneID" id="110990015"/>
    <dbReference type="KEGG" id="aplc:110990015"/>
    <dbReference type="CTD" id="64318"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="9">
        <location>
            <begin position="247"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="8">
        <location>
            <begin position="594"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="476"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022110469.1"/>
        </source>
    </evidence>
    <sequence length="877" mass="100384" checksum="8D27E99BB5636943" modified="2022-01-19" version="1">MAKKRGNTGQNVHKMKVSVTKLSNRHSSKSSLTKRSKILGKSIKSGPGKKPPKGFWNRASHAAGVKAGVIKEKKPQRHVHRSKQEETDMSKVIKDEELEEDEEEEDATEDFTGEDLEYIQSMGFGENFLSGVNDSEPPSSQKCNKRKRVNPDNELKPYEMTPRSLPLARGDPPQKMKQLLPIKHSKGFEFRWEEAKDEEDKERVTEDDDIIQDIDMKAQADVVEEKPVLPALSTVELFTLRERKLAQRKQRIASLSHAVLTDPEQNVNKLKDLRLMLEEKERDVIVTVQKLVMVSLVEVFKDIVPGYRIREWGEKAKAVELSKEVKKKRDFEEGLLKQYKAYLSFLEKLSRGHKKSKKQIRKEQEGKLTFDLPDGAKRSLSEVAVRCLCTLMTSLHHFNYRTNIINVVVSLLTSENEEICNTCCLNIRQLFKTDHLGEAVLDAVRFISRLVRSHNYSVSPKIMNTFLSLKIKDVALPEEEEKKKKLIEKREKLKKMSRSQRKHQKRLVEVEKELQATEASENKNKRKKLHTEIIQSVFATYFRILKKASNSVLLSSVLEGLSKFAHLINIDFFDDLVKVLYTLIDSGDLTYRDSLHCVLTAFLILSGQGDVLNIDPTKFYTLLYVTMPQVHAGESCADAKLILDCIDAMIIKRHKQVTFQRVLAFLKRLATLSLQMMPNGILGYGCAVRDIMKWYPKSDLLLDSESFGSGTFLPELPEAEHCNAQSTALWELHLLKRHYHPTVKAYSDHLSKGSPLMGAGTIPVDVSRLSAQKIWKEFNPDQMTFNPPIDTRRNKQKNVVLKDSNSDYIQEDLGELISQTTASTSEICDINGCLTDKILSNLLSNPEDSDVCLKRKHRRRVEHIPRKRKSNYYEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A0S8</accession>
    <name>A0A8B8A0S8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110990087 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110990087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110590.1">
        <property type="nucleotide sequence ID" value="XM_022254898.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110990087"/>
    <dbReference type="KEGG" id="aplc:110990087"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="158"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022110590.1"/>
        </source>
    </evidence>
    <sequence length="1792" mass="200762" checksum="E9597B427D5E3FAF" modified="2022-01-19" version="1">MILFAVISFNAICTKKQKLLLSVQTHLPHRSTTLDFELDPEISISSLKELIHRMIGVPPQHQHLYTQANFQLFDLLHENGIDKNKIISLSTDEPTQDGPKATCQFGDEAERPLPETHYKTRSETEQNEATLREEQNPGNRQTPDKDKPEVLRCGKQKLQVFVRNPLLHGPKTLCFHLHSETLVSTLKESVYRKIGIQPQHQLLHIKRNVLNFQLHDLLTLNECGIQQDENISLCLPARGLLGGGRKDPKDLAMQHTDKPKNDGIADTAAESQQRGQQSCKSEAQDSPVKMMETSQGVSSSQQKERTQGQDSQQGSIETARSRQGEIGHLKEPQSQEEQIEEVTDISIPLPSAASAKHWGQSGDLTESSDQHRPLTEKQQQFDEVTDLKYKERTLMPAVPQLWPNDRQLIRTKVQSPQLCQGSDPDSHQKHATVSHKLLQKPGQEQIEDVLKSKPEERGDMRIPQHYQTEHTCMRHEEPGDPHRQKQQLVGPRDVIPAVQPRQEGTTNSDPSSQALASQRYTHPLSEIQKCVAWQQVSGDLAVGGSNNPTFLGPVHNPTIQFTQHVTLPRPSSEFPQLPITTDLARSRLKNDAMTQLLWKALTSATRKHGEDYVMNVFFAFMESLDGQVEQVKSGSITFVVRILSRVGLEKLWDMYTTGELSKKLSEIFITDELTKEDKSDLSILVTILESDYEQACRFFEELESAGHEGDDKDTRTKTEVQKNQLGGVQSSLVMRADSSDPAEGAADRCEVALKTLYMSTGTFAKVMKWVSGESQKIQMPKPLLEKDGERLLHFEDMFVMTTQDGNPIETAILTGEEGAEMTFLLENIAYEWAAGRSPVLWKFKLVAFLEMGAFQPESDLNVVDTIYEQLLGKDTDVDRGDLVSFVDTNPHKVLVLLDGCDRFMTNDPDESFDETVIESIILKILRWTTARGIHLLMTFFHSNFHNLRRKLLFREPFIRVTVAGVSEEEIEKYVKAFYSKEPGKAENFLRRIQSSELLSDWAKNVKLVPLLCLILKNSGLPETMTRLYDKALKYIFTRHSDMSQDEISQAVIALGKTALSGLVSLEQRFSLGEFPEKEFDEGVLDKALQAGLLTRQPALSLSGQKSNVCSIKFCHPKIQDFCTAKYCQSVADKDIAEFQKILDRISDPGAFEFLLYICCGDNEHCARYIVNMLLMKGYTPMKFVLQTKQEKWRVHEVALNCYFESQSVGLLSVDFIESFMTENMLIQCEKNDSLKSCMWFLEHISKHVSGNDYLARVRSVTVFKCNLSGFGVVLASSLAGMKHLHSLRLYSCTLSGSFLEQVLSSVGRAGNLTKLGIWHSVGVSDDVEKWSASLKTVTHLKSLTLCSCHIEAQDFTHIGRSLVEMTDLAHLDLPNNEKLGGITDVWAFRLHSLRNLEELNLSRCNIDAQDLPNVAKSVGELANLTDLNLSCNMGLGGHADTWAASLKSMTNLKKLVMSYCGIECGDVKYLAEAIGQMEDLMQCRFCGNEVDVVVESSVTCIRVKNKMCSLSSKDMAETLVSLRSRKDLVSLVLHGITGLSGCAVLWTPPLRELTHLEVLVLNDCSLQTTDIQHLGVALSQMRSLQELRLDCGMESLDFKHLAEAVGRAQNLIRCDFSGSKAKLRVMSQDGSIQLNIQECSLTGEDMADVLQSLSSREDLVGLTFEGIPGLCDSGALWTPLLPKLTRLKKLELHVCSLQSTDVKHLAAALSQMPALKYLCLKGNWSLGGAAKIWAPSLKEMIHIVRLNVSRCGLQLDDVEHVAAALGQMPNIKELVWKKIRVRVPVQKRGPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A118</accession>
    <name>A0A8B8A118_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990379</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111047.1">
        <property type="nucleotide sequence ID" value="XM_022255355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A118"/>
    <dbReference type="GeneID" id="110990379"/>
    <dbReference type="KEGG" id="aplc:110990379"/>
    <dbReference type="OMA" id="YATWLNC"/>
    <dbReference type="OrthoDB" id="10006415at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111047.1"/>
        </source>
    </evidence>
    <sequence length="185" mass="19964" checksum="F1C16337E0EE6759" modified="2022-01-19" version="1">MAYVYSNALNVSIALIVFGLIQIGMFVSCLFGCFAAFPMDFASPAWSGGLSVFAGLFGIFMICSYKEIKWGKLFFFLSIVAMVTSLACIIITAGHTMVNEYALADAEAREGYEPGSRGTFIATGLAINGAILVFGLILLICSCYATWLNCCCDNRPSKGYVMTLDTVQTENAYVTLTVPAEPRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1T0</accession>
    <name>A0A8B8A1T0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110990311</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110990311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022110925.1">
        <property type="nucleotide sequence ID" value="XM_022255233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1T0"/>
    <dbReference type="GeneID" id="110990311"/>
    <dbReference type="KEGG" id="aplc:110990311"/>
    <dbReference type="OMA" id="RAYEICH"/>
    <dbReference type="OrthoDB" id="10060112at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058912">
        <property type="entry name" value="HTH_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF11">
        <property type="entry name" value="GIY-YIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26215">
        <property type="entry name" value="HTH_animal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="1">
        <location>
            <begin position="465"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022110925.1"/>
        </source>
    </evidence>
    <sequence length="643" mass="73154" checksum="C63ED49CCB38A779" modified="2022-01-19" version="1">MAITSLQIDLLICELSCHLDKDVATNEATLKSTLHQQDFVKISSFTQSSSHHAFTTSCNKQLRKFQRLSHRKMGSPISRRQTPQASLPAHLRSQSEFQRHTVVNLSQCTQSTTETDVLSLDMNFTTPPRAIPLADIIQAMEPVTQKLDKTTADNIQVKIHQALLHTKPVNPNLTIPEVEALHDLCSDKSIHIITGDKGNATVVMDRAAYPNKVQDTLTSGIYCPLPKDRTQAIKKRIASHLLALHCSDSIPADLYYRLRPSASTCPRFFGQPKIHKPDIPLHPILSSRGSLMFETTRFVTGILQPLVSNTPHHISKSTQFVELTRNLSLQPVMIANLIHLCVSSSYFKFQDKFYEQTAGTFMGSPISPVLANISMEEFETSSVLTNNLKSTIWLRYVDNTFVIWPDGQDHLQEFLDYLNKQCPTIKFTMEQEQNRHLSFLDVQLSRNPDGTLIHRVHRKPTQTDRYLHQISFYHPAIKTSVNCTLIRRAYEICHQNNLHQELHHIKPSPRTLRSPISGVPPIPRGIMVTYTQSPPNPHRHSMLYRTWAPPPTNSGASCSQSTSKNLPTRLQEHHWHGQREYDKSAVIKHAHSMDHHIERDKAELITPIQNWLLRRIREAIQIFWHNIVPKTLVSSSATSGSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A1Z0</accession>
    <name>A0A8B8A1Z0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110991005</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110991005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111753.1">
        <property type="nucleotide sequence ID" value="XM_022256061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A1Z0"/>
    <dbReference type="GeneID" id="110991005"/>
    <dbReference type="KEGG" id="aplc:110991005"/>
    <dbReference type="OMA" id="HIHASTT"/>
    <dbReference type="OrthoDB" id="10045204at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022111753.1"/>
        </source>
    </evidence>
    <sequence length="133" mass="15135" checksum="09A7B9B3A394134C" modified="2022-01-19" version="1">MTGIADKSEKLVRRGVQEVFAALRIFVDFLLILILELLRFLAYNVFGLLFVGLLTTFGDYFFKPVLAAMFNSILQPLAVFLYNVGMALKTIFGPLIDIFRALLIQFAMLLRAFRLVEVNWRAGPRDTRGVEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHT8</accession>
    <name>A0A8B7XHT8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110973674 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080364.1">
        <property type="nucleotide sequence ID" value="XM_022224672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHT8"/>
    <dbReference type="GeneID" id="110973674"/>
    <dbReference type="KEGG" id="aplc:110973674"/>
    <dbReference type="OMA" id="EHANNNY"/>
    <dbReference type="OrthoDB" id="10430108at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034527465" evidence="3">
        <location>
            <begin position="26"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022080364.1"/>
        </source>
    </evidence>
    <sequence length="210" mass="22602" checksum="0121ABF830DB5822" modified="2022-01-19" version="1">MGGINLSKLLLALVGCLCASLAVSASVIEQHGSRYSPPLARLLPRDADPKQKIEGTTNLPDATPGDTPPPYIVNSLTEAIALAVISGICGPSLFALIGCGIRQIRLTWDDPFAGGERPVDEAAERRKRKKQQQQEEQLADDDDVEIVNNNIRPAKAVVNNADPLLLDRVTTLDLDKIRAKPLPASKFSNTEKNLAGKVNKGYSKTAEDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XII2</accession>
    <name>A0A8B7XII2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein FAM171B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110973412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022079932.1">
        <property type="nucleotide sequence ID" value="XM_022224240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XII2"/>
    <dbReference type="GeneID" id="110973412"/>
    <dbReference type="KEGG" id="aplc:110973412"/>
    <dbReference type="OrthoDB" id="8950207at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018890">
        <property type="entry name" value="FAM171"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048530">
        <property type="entry name" value="FAM171_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31626">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31626:SF4">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10577">
        <property type="entry name" value="FAM171A1-2-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="FAM171 N-terminal" evidence="3">
        <location>
            <begin position="55"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022079932.1"/>
        </source>
    </evidence>
    <sequence length="364" mass="39688" checksum="20421B81F60517CD" modified="2022-01-19" version="1">MVNLKLTILDAQNNPVYDTTVRISDAGGESKFLVVPVMTNIVDVSSVIPQDGSLGVVVSKMGYTSNAVRWSSGDSEVFEIKLLQLKSATVEILGDEVLIKTDVNAYGQQATFQFEPALINGTTINAGYVLTSDLSLIPAINTAGIDDSNSVRLKPLGALELTISDQNSGLVVPIGGNVDMMVPLEQGLNVKDGMEIEIWTYNETTAFWEEAGTGVIIIDQDLLVYWSFTAPHLSWWMAVERQDTSTPRPPIKTVDPTKRPNSSNLLRTQLIVYTLIAVLLFSPLIIIIVCIIRCARKKSDPKKDSMRGTLPVESSEMEIEMHPRGLSNKGMTADTVALEVNDNETAGPTDPDASTSRAEIQFRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIL1</accession>
    <name>A0A8B7XIL1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cadherin EGF LAG seven-pass G-type receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110973494</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080046.1">
        <property type="nucleotide sequence ID" value="XM_022224354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIL1"/>
    <dbReference type="GeneID" id="110973494"/>
    <dbReference type="KEGG" id="aplc:110973494"/>
    <dbReference type="OMA" id="CRFKKDF"/>
    <dbReference type="OrthoDB" id="1100386at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15040">
        <property type="entry name" value="7tmB2_Adhesion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45692">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034629663" evidence="9">
        <location>
            <begin position="26"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="809"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="847"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="891"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="967"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="231"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="269"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="312"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="10">
        <location>
            <begin position="357"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="11">
        <location>
            <begin position="567"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="742"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022080046.1"/>
        </source>
    </evidence>
    <sequence length="1021" mass="111429" checksum="6423B7F0C12BC4E4" modified="2022-01-19" version="1">MDRWWSCRCLFLLLLIGSWLDSARTQNGPELSSCQLPEQLQQGEGGVTVNPPGFDSLSIDGENNVDDGIRVLFFFNGERPLRGFSLQAWGMNASVPVGPTGEWLTPADRTFRGVSCQAENDTITLSSLGVEPVPGVNVFNWIANGSPYCDFLFRAHGLTVSSEIIEFRTAIVRRHPCQNGGVCVSNGTEFSCRCHVGYSGTRCQTFDDTATQFTDAICECPVQGTAGLSCEKDPCQLSPCLYGGQCSFEGGLARCLCGALQDGAMCEMGPDPCRYPQMCYNGGTCLPWAYSRDGFRCQCPSNYTGPNCQTEITGACSSQPCINGGTCSASPDTDGYTCACPTIYGGQNCENQVFPADRDECASNPCSDGSTCFNQINGFMCFCDNGRYGPKCEFEMELCESNSCNNGGICYKRPGAPCKCFTDVNSGLRGCDISPTCDVTDILYHLSLIPVAEVNLELISTALANATSNYDRIDSAGVASTATTLENIVNVRSSSTPATENVIMMVDNLLNLPDEVLAGSYSAARIQRSFEEQLTYVRGNLSWVTKNLAVEVVQPRRQANDTYTLLGYASISRDGTLDNTFQNNDERLYTDPIVMPPDRAEAFIGLPAEVFSQVSREEPPVVFTVYLNSILFQRETPGSFALPNGTRLFVNSRVISAIVGSPDETIENLASPVITSFIPTNASLTNEPVCVFWDVESTNWSTEGCTRSTTSGASSPVVCHCDHLTSFAILVSYTGDIKDYVLDVVSKVGCAISIVALALTILACLSYRELRNNPAKKSLINLCVSLLALYVVFLAGIEQAQSPVTCIVMAALIQYFFLTSVCWASAEAMNLFYLLVITQRLLLTRYLVKLMLFCWGVPMVVAAFTFLVPYLTTGEWELQEAYCFLPPGNALYFGVLLPVGVMLLFNVLVFVLLVRRLVCQRVETTRTRRETSVDAAIRHGRLMLPISLLLGGTWAVGFLAVEEATSVFQWIFAVLNSLLGLAIFLLFIVAKKTGRKGLKRLFCVEQIRNFSSIQSSSQSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XJL6</accession>
    <name>A0A8B7XJL6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9 10" type="primary">LOC110973652</name>
    </gene>
    <organism evidence="7 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9 10" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="RefSeq" id="XP_022080330.1">
        <property type="nucleotide sequence ID" value="XM_022224638.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080331.1">
        <property type="nucleotide sequence ID" value="XM_022224639.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022080332.1">
        <property type="nucleotide sequence ID" value="XM_022224640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XJL6"/>
    <dbReference type="GeneID" id="110973652"/>
    <dbReference type="KEGG" id="aplc:110973652"/>
    <dbReference type="OMA" id="ETITVHC"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
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            <end position="118"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022080330.1"/>
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        <source>
            <dbReference type="RefSeq" id="XP_022080331.1"/>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022080332.1"/>
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    <sequence length="118" mass="12643" checksum="2DCCF3B04674408D" modified="2022-01-19" version="1">MGDFKNIMVSDGVVKDIIRQGGPTKVKAGETITVHCTGSLAGNPPKKFWSTKDPGQQPFSFAVGLGKVIKGWDEGCLSMSKGEIALLKIRSDKGYGKSGFPAWGITPNADLEFEIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XKQ7</accession>
    <name>A0A8B7XKQ7_ACAPL</name>
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        <submittedName>
            <fullName evidence="24">Uncharacterized protein LOC110973761</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LOC110973761</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:animal organ morphogenesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Cadherin-domain_protein"/>
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        <property type="entry name" value="Cadherin-like_dom"/>
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        <property type="entry name" value="Cadherin-like_sf"/>
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        <property type="entry name" value="Cadherin_CS"/>
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        <property type="entry name" value="LDL_receptor-like_sf"/>
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        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
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        <property type="entry name" value="LDLRECEPTOR"/>
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    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
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    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        <property type="component" value="Unplaced"/>
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        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="RRM_CSTF2_CSTF2T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.70:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="cleavage stimulation factor subunit 2 isoform X1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022081731.1"/>
        </source>
    </evidence>
    <sequence length="458" mass="50244" checksum="CBA18D76CE1E6C28" modified="2022-01-19" version="1">MYMPQRVDYIRALCSTRRVLKFFAFGCANGTEMSAIERSLRSVFVGNIPYDATEEKLKDIFSEVGPVISFRLVYDRESGKPKGYGFCEYKDQETALSAMRNLNGYELNGRALRVDNAASEKNKEELKNLVPAAPASESPFGEAVPPHEAPEAISKAVASLPPEQMFELMKQMKMVIQNNPVEARNMLLQNPQLAYALLQAQVVMRIVNPEIAVTLLHKQVNAPQALLPPELPQPAMGVPTQQQQQQQIPHPIQQQPQQQTMLAGQGPGGMMRPLLGPNAMDNRGPIDSRGPIMQQGPSGPIGMDRMDTEHMGQRGMPLGQDRGPFEHRGPMDPRGPAPDIRGQTDPRSHDPRRPDLRGQDIRGFDSRGGDPRTQPMMAGDPRVLERGMPGGPQGGPSGPGGPGGFGNTQPTQQDQDKAALIMQVLQLSPEQINLLPPEQKASIMFLKDQIARSQGQIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNY2</accession>
    <name>A0A8B7XNY2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methionine aminopeptidase 2</fullName>
            <shortName evidence="12">MAP 2</shortName>
            <shortName evidence="12">MetAP 2</shortName>
            <ecNumber evidence="12">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110974897</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="function">
        <text evidence="11">Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022082523.1">
        <property type="nucleotide sequence ID" value="XM_022226831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNY2"/>
    <dbReference type="GeneID" id="110974897"/>
    <dbReference type="KEGG" id="aplc:110974897"/>
    <dbReference type="CTD" id="10988"/>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000106">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000003">
        <property type="entry name" value="Methionine aminopeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="15">
        <location>
            <begin position="201"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="30"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022082523.1"/>
        </source>
    </evidence>
    <sequence length="511" mass="56451" checksum="B1205C18388F2444" modified="2022-01-19" version="1">MHAHSTTRQGPARCTYMYNMATTVAQKNAEIKTDQVEDDVVGNAETGADKKKKRRKKKKTGGSAAEAEGDGPVTNGEVEKLTDDVKKQTLEDRNVGAVIGEEKEEGGEGEGDTENSKKKKRRRKKKGGVLCVEGEGQTIPCAGKKQTDPPTIPVSELFPDGAFPEGQIMEHPVGNGQTAAWRVTSEEKKALNKAHNDVYNELRQAAEAHRQVRKYVQSFIKPGLTMIDICERLETASRKLIDENGLAAGLAFPTGCSINHCAAHYTPNAGDPTVLQYDDVCKIDFGTHINGRIIDCAFTVAFNPRYDPLLEAVKDATNTGIKEAGIDVRLCDIGERIQEVMESYEVELNGKTYQVRPIRNLNGHSIGQYRIHAGKTVPIVKGGEATKMEENEFYAIETFGSTGKGVVHDDMECSHYMKNFNAGHVPLRMARAKLLLHKINTHFGTLAFCRRWLDRIGETKYLMALKNLCDTGIVDAYPPLCDVKGCYTAQFEHTILLRPTCKEVVSRGTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQ23</accession>
    <name>A0A8B7XQ23_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ileal sodium/bile acid cotransporter-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110974748</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082277.1">
        <property type="nucleotide sequence ID" value="XM_022226585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQ23"/>
    <dbReference type="GeneID" id="110974748"/>
    <dbReference type="KEGG" id="aplc:110974748"/>
    <dbReference type="OMA" id="YIPAQYY"/>
    <dbReference type="OrthoDB" id="203097at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF65">
        <property type="entry name" value="ILEAL SODIUM_BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034238734" evidence="9">
        <location>
            <begin position="32"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="472"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="495"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022082277.1"/>
        </source>
    </evidence>
    <sequence length="514" mass="57005" checksum="06EFFBDC85E3556D" modified="2022-01-19" version="1">MLLLQISAFHRMVFVHALCLVLLNYPYCVRGEFNFTMGDSEEVAVTFRETVEVNLTVTYSDLLGAISLQSTDTSVVTLTNTVEITITENTTFPFNTTVGIHGQYVGRGGVRIMQDAKEISTRIVNVGPPFQELGNIATIILVVWLVISYVVMAAKVEPRELWERIKPPWGIIIGMLCQFILMPPVAFTLAKCFDMSGASAVGLVLVGTCPGGFFSNIEVLLLDGDLVLSLAMTTFSTFLAVGMMPLNLLIYAQPFIDGDGRLETPFRELLIQLCGLVLPLVIGVPFFYKFPKARKFCLKLVKPFTFLLMVLGVVLYIPAQYYVFFGDWKVWVTSSIVTLIGAFLGMAVARIVNFNYHTSITIAIETGCQNTLLAVSVAKLFYVAPESDVVAVIPLLIAIVSGIEGFVIVFFYYLYLFLTKKPTKVAPDEEGQPPASEDGQAGDDDKESREYELNSSTKDKKKFADDFVTAEEDFKSQPLAEARTQDERASPQIPKKPKQGKRNRGYLVDEILKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRU6</accession>
    <name>A0A8B7XRU6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110975415 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083573.1">
        <property type="nucleotide sequence ID" value="XM_022227881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRU6"/>
    <dbReference type="GeneID" id="110975415"/>
    <dbReference type="KEGG" id="aplc:110975415"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000299">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF83">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="422"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083573.1"/>
        </source>
    </evidence>
    <sequence length="618" mass="70957" checksum="CFB2226707FC4C17" modified="2022-01-19" version="1">MAATVDFRRRLQVLNFSVLVVIFMLLVYFKPSHCQLEIMSPSRILSEVEKSCVLVLFNRNFASVETSFANALHQIIMTRSEVTFGTSGLVLNHEFVWPDGQPLQLVNGNTRVPVSRDSDGSLVVFPKQKKDRKCLITGPRRNPKAELFTEPLIMKTVLNWVNDKCDTYISLNGGLTYQGLHRESILQNLFSMSHVSDFTMLDLNHKHTEEGNLISQSKFPNASRKEDEMIWNCEHSNDYEEGFCNESERKTSNKHARLVSTTDFRSAKLAKDKLKDVAEEFPDSCHESGGKNPGPGKVFPQCERLSVLPTKGQFFHEFLKISKPVILEGAALHWDAFHKWTMEFLREHYSDKEVHIKLAPDGLFEGIDSSSNWEDYGTFKIPATVLDKLPFPDLVVVRPATMNLKFAEFLDMISNVSHKAKPRASAYLEYSSIPDYLPELEEDIPEFPFAQDLLTRRHLNIWLGDGNTLGKLHFDPFDNFLCQIRGKKQLTLFDPHDNSKMYEGHIPEAELGYNRVSGQFRRKKLQDSTAMVMAPVDIVDPDFERFPAFAEARPLNCTINEGDVLFMPAFWWHEVQSYPNVTEGRNLAVNFWYEPFLTKEFPCAHCKLDVNPFYRHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRX8</accession>
    <name>A0A8B7XRX8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Retinoic acid receptor responder protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110975107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the H-rev107 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082947.1">
        <property type="nucleotide sequence ID" value="XM_022227255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRX8"/>
    <dbReference type="GeneID" id="110975107"/>
    <dbReference type="KEGG" id="aplc:110975107"/>
    <dbReference type="OMA" id="NINDLEC"/>
    <dbReference type="OrthoDB" id="421951at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070292">
        <property type="term" value="P:N-acylphosphatidylethanolamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051496">
        <property type="entry name" value="H-rev107_PLA/AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943">
        <property type="entry name" value="HRAS-LIKE SUPPRESSOR - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13943:SF77">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="LRAT" evidence="6">
        <location>
            <begin position="32"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022082947.1"/>
        </source>
    </evidence>
    <sequence length="199" mass="22537" checksum="34B3CC97F13DD417" modified="2022-01-19" version="1">MANENRFGKVSDWRDSTSVKALPSEARPGDRLEFKRVCGYSHWAIYIGEHDKIEHAVIHFSLHEGALIFSALTCSCSAGIASSQPEIRADSIETVLGNSGQVRINNSKDRDTAPFDTSIIVQTAKDKQKSETQPKYSLLRNNCEHFVNSCRYNQTVSEQVNDAVVWLIFTVTKNIVPVVAFCIFLLFFWLALMNAQRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XSS6</accession>
    <name>A0A8B7XSS6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Metallophosphoesterase 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110975620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. MPPE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022083918.1">
        <property type="nucleotide sequence ID" value="XM_022228226.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022083919.1">
        <property type="nucleotide sequence ID" value="XM_022228227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XSS6"/>
    <dbReference type="GeneID" id="110975620"/>
    <dbReference type="KEGG" id="aplc:110975620"/>
    <dbReference type="CTD" id="65258"/>
    <dbReference type="OMA" id="LHCMKYP"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08165">
        <property type="entry name" value="MPP_MPPE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039541">
        <property type="entry name" value="MPP_MPPE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF0">
        <property type="entry name" value="METALLOPHOSPHOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="54"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022083918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022083919.1"/>
        </source>
    </evidence>
    <sequence length="385" mass="44336" checksum="2813EE5259AD6A37" modified="2022-01-19" version="1">MILLGRHLLRLLLAAFALLIFCEFFIYYFIALPCSWPKLPPGDGTGEGKMAPLRAMFLADTHLLGSRQGHWFDKLRREWQMQRAFQTAMTLSSPEAVFILGDLTDEGKWASDQEFRETVDRFNKMFRVSENVQFHVVVGNHDIGFHEWVTKSKLDRFQETFDIPPVKILTIKGNVFVLVNSMAMHGDGCFMCSPAMDKLRSASEKLNCTRHGSPTGKVDESKKTKERCQKYKKLPNVKPILLQHFPLYRPTEAKCTGPDAPTLTQQQEKNKERYDVISKTASQQLLSWIQPRMILSGHAHHGCYVMHPGGVPELSVPSFSWRNRNNPSLIMATISKDHFEYSKCFIPQETSVITIYVFFTMLILIWFVVSILQNWGRNFKKNRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XV00</accession>
    <name>A0A8B7XV00_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110975494 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110975494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083721.1">
        <property type="nucleotide sequence ID" value="XM_022228029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975494"/>
    <dbReference type="KEGG" id="aplc:110975494"/>
    <dbReference type="OrthoDB" id="10501229at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="84"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1236"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1136"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1307"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022083721.1"/>
        </source>
    </evidence>
    <sequence length="1351" mass="147541" checksum="CE30EE1524CB7562" modified="2022-01-19" version="1">MPLAAQRSKDDPDDEIPTSSSSSHSSPTLTPRRWSHKKFGHSKRPAIQLAGPPTLCQQLQQRALPSTATLNTEGKTRQSPRRDEKKKRRRESDAKWRSNLSVCFKHLETKLLPGRNCTKTRLSKEMIVQKTVQKVQYLEAVFMFLKQADRHGNKSCFSPTRGHQSLQSARREFARKFYYKYRQKPSTETTSVEKTEPKAVQQEGVLPRFGKTNSEQLVPPLVKTTATGPAMEYPTECDPSRSNVPRERAVPSTPTKSLVCEERDLDTEDSWPETLNLTPKHIPNNAFNGHIQQTQVMTNPKRRALHDVARVPSQSPVRDQRSYVPTSPSLYSPDRPLVPSVPSHMKVGDRPASFDNHSVSPAAKNGIAGPSGLALKGSARSPARKYDEVTPHWPAYWSPAKSSAHRSPAISPGLASPCQVPRWSLPGTPVTNRSARCRSVPPFWPPSPASRSTDSQVKTSGHTFCSHPSYSPVHSPSVSHGTNDQIRPLYRSPARTLADNPTTSQAGTVLTYSALLPDLIMTSPSKRYKIVGKSVISLGDTGPETAQILTSPDQADDAPLPNLEPEGRVTPDLTCQEDIPSWKEDDRYQKRTPYGTPRSATHPPSIAPKRRPSAWSAKFVNDVRRATLGPGPKRAKSGRCKRLFCDDSGDSIAGQPIIKKEKLDQINAGSMVGDGKKAPRRKYHKRATAARVRPRNPLNSEVGSHVCGITRQRNCQHKSRAPICTPSPASSTEASPYRHPTAKLRSQSKASRRKSQTPRKVMRRGPRIVIEGAGMADVELDVEEIVDVEEVELDRPLEDVGKTTNGGELFLDNSSFLDQDSSQGSLLLSEIPQLPDDIITPLLLSNESSQCFLEDSDLEKTLQSEKYAIPPTINRLNTTKSDDEIVLTILELEKESRTSSSMHSSPDSIGNQHADPTPDTTSVNVADQAGLPDHLQGALLEAYRLMTGKSGTADSPPAVILSPIRLSGLSSLNEKLSPNKSSFYLISPVKQDSFSLEADDEEKMLLSSENDEDQITESMARFASRALSSQGLNTCNQKPAESDLEVSDVSSSQQVYQGAKQALLNGQIVGKTPAGPQSSCHQPQSTLICIDSGTPTKNQPQLPYSLPATVPLALQFGSQNPNSAYPTSDTEVHMGSSYTSTSPCLSPLSTSTLSTPGRYMSLTHVSQSSAETSLSSELPKEPYSWSQSSSPVIKQEPWDWTDPPDLQADESLDDMMGDEDLLAKYYQCLGGVDTARGNRSEQGQLEVPDWNAEKKVASQSPGDGITSSASPTSSSLLSFSLATGRISTGSPATDGLQSAEYQVVPSLSTNGNPAVRQDQMTGNKFDSRGRVGKKSAFDTFFWGVETGTREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XWH3</accession>
    <name>A0A8B7XWH3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Allograft inflammatory factor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110976345</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022085223.1">
        <property type="nucleotide sequence ID" value="XM_022229531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XWH3"/>
    <dbReference type="GeneID" id="110976345"/>
    <dbReference type="KEGG" id="aplc:110976345"/>
    <dbReference type="OMA" id="RETINYH"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097178">
        <property type="term" value="P:ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049025">
        <property type="entry name" value="AIF-1_EF_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042433">
        <property type="entry name" value="AIF1/AIF1L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10356">
        <property type="entry name" value="ALLOGRAFT INFLAMMATORY FACTOR-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10356:SF0">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21008">
        <property type="entry name" value="AIF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022085223.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="16862" checksum="50D1E22B24983E3E" modified="2022-01-19" version="1">MMHEKAYSDRKRSQEDAFAAYNKEIITSGKYSEDEYPDLEERLVSYKGMFMEFDENSSGDIDIMELKRMMEKLGQAKTHLELKKMITEVDTTNSGTIHYNEFIEMMLGKRNSILKLILMFEEKKQEKERPTGNPPKRDLEHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XY88</accession>
    <name>A0A8B7XY88_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ERI1 exoribonuclease 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exonuclease domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="primary">LOC110976078</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ERI2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022084739.1">
        <property type="nucleotide sequence ID" value="XM_022229047.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022084741.1">
        <property type="nucleotide sequence ID" value="XM_022229049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XY88"/>
    <dbReference type="GeneID" id="110976078"/>
    <dbReference type="KEGG" id="aplc:110976078"/>
    <dbReference type="OMA" id="YESTCWE"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000062">
        <property type="entry name" value="ERI1 exoribonuclease 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="562"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="444"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="531"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022084739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022084741.1"/>
        </source>
    </evidence>
    <sequence length="691" mass="76968" checksum="1F99458EBB4F99FC" modified="2022-01-19" version="1">MKSTKELARQLGLLRRHSTSLNQQSRDVRRVGKTNQIFSYLIVIDFESTCWKDKRNVGQEVIEFPAVLLNTSTGSIESEFHTYVLPEENPQLSAFCTELTGITQDQVESGVPLRVCLSKFSRWLTKQESEKNIAYNTGDDGKKLCTFVTWSDWDLSVCLHYECRRKQLLKPPALNSWIDLRATYKNFYKRKPNGLHGALQDVGIEFHGRQHSGIDDARNTAQLAWRMMCDGCVMSVTRTMPGAQPPKRKQTTQPSDQPTKIQVKPSANKEKQRPDSLCLNTHRHAEPEDRLISHTQGINNDLCNTIEPLSSSIHFRIWKDDTQPANIHSIIRPKTSVPSTVRHDRGDDEIVTKSSRDVAIEVTSVQTSLGAQVQNVSKVSEKRLDRGKQTSVLRSTLDIGNNQNNHSEICGRKQVCSETSVTSSDAGLRQRIVTDAMNKISKEVVSSSENTGSAVQNSRNHLKLVDSAKTSPQSENLSRSHLPGPSSRKSVHYQAPVILKTPSNTPVHRRPREPSPMNGFRTPYAPGSHHTPGSSTFRTPTYSSKKLSTPPLIGGKITPPMCQCGRRAKRCTVQSPGPNMNRAFYSCTSRRKSSEAGLRDVTNAGKGCGYFKWESVVLAEKQQSFITTPVKQESCWSAQKQPGVPLDPAATVERKCPTPSCSSAKIVTPITGFSGKRLGTAMRAVWRHQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYN2</accession>
    <name>A0A8B7XYN2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4">Uncharacterized protein LOC110976758</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">LOC110976758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086013.1">
        <property type="nucleotide sequence ID" value="XM_022230321.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086014.1">
        <property type="nucleotide sequence ID" value="XM_022230322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYN2"/>
    <dbReference type="GeneID" id="110976758"/>
    <dbReference type="KEGG" id="aplc:110976758"/>
    <dbReference type="OMA" id="FSHGENV"/>
    <dbReference type="OrthoDB" id="10071091at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022086013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022086014.1"/>
        </source>
    </evidence>
    <sequence length="251" mass="28012" checksum="FA6C29FF482D4B6B" modified="2022-01-19" version="1">MSSNNKENVQNDKKKKSKPRLSIKIFSSNSKKKDSLKKIREELHSPDGSYKPHLEDKQVETPAKEVKDVEVVATEETDSDTSEETIPVSAPPPAFRPGRRRSLSACADVQDTLIKIKGKDEEDNREEKIEEEEEQDDQLSPLPLSPTKSCLRTRSATFGYAGEIIVTASRPRTVSFSPETVDPPPRTQKYRAWIEARSKPPPVNVKHEKHKQKMNQLKKVNMADYLSSRKPTSGSGIMGSSSAAFGGGMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XYU8</accession>
    <name>A0A8B7XYU8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Axin interactor, dorsalization-associated protein B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110976796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIDA family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086074.1">
        <property type="nucleotide sequence ID" value="XM_022230382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XYU8"/>
    <dbReference type="GeneID" id="110976796"/>
    <dbReference type="KEGG" id="aplc:110976796"/>
    <dbReference type="CTD" id="64853"/>
    <dbReference type="OMA" id="KLHAAWC"/>
    <dbReference type="OrthoDB" id="428576at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048264">
        <property type="term" value="P:determination of ventral identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046329">
        <property type="term" value="P:negative regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.360:FF:000001">
        <property type="entry name" value="Axin interactor, dorsalization-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000059">
        <property type="entry name" value="Axin interactor, dorsalization-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.360">
        <property type="entry name" value="Axin interactor, dorsalization-associated protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025939">
        <property type="entry name" value="Aida_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023421">
        <property type="entry name" value="AIDA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036818">
        <property type="entry name" value="AIDA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28654:SF1">
        <property type="entry name" value="AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14186">
        <property type="entry name" value="Aida_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08910">
        <property type="entry name" value="Aida_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109779">
        <property type="entry name" value="Domain from hypothetical 2610208m17rik protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51911">
        <property type="entry name" value="C2_AIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 Aida-type" evidence="4">
        <location>
            <begin position="163"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022086074.1"/>
        </source>
    </evidence>
    <sequence length="312" mass="35262" checksum="FA520C9F690143A5" modified="2022-01-19" version="1">MGDKHKLVARWRASLTRGTGHDSWGQLVEAVDEYQMLSKQLLKETSHEATLFNDSQKRTLSKIAACLDLRGKALQSPDNTQGFTLEELKKVDSAFESLLSSSQSEFPVSVPVEAALFRPTVKSGNFELDLDGDEIDEDEEDETGRNKTSVIVSPGIKPLGKLFPMIPRERGSTNLIVRVEKIGLKDASTYLDPFIVISFKDNKGIDVSKPQETPVALRREDPYIIFGVDVHVQKSLEKLPKGTAIFFEFKHYKLKKRTISTKCFAFMEMDEIKPGPLVIELYQKPTDFRRKKLALLTTKPLYLHLYLNLIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XZD0</accession>
    <name>A0A8B7XZD0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14 15 16">Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 15 16 17 18 19" type="primary">LOC110976883</name>
    </gene>
    <organism evidence="13 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15 16" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022086253.1">
        <property type="nucleotide sequence ID" value="XM_022230561.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086254.1">
        <property type="nucleotide sequence ID" value="XM_022230562.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086255.1">
        <property type="nucleotide sequence ID" value="XM_022230563.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086258.1">
        <property type="nucleotide sequence ID" value="XM_022230566.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086259.1">
        <property type="nucleotide sequence ID" value="XM_022230567.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022086260.1">
        <property type="nucleotide sequence ID" value="XM_022230568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XZD0"/>
    <dbReference type="GeneID" id="110976883"/>
    <dbReference type="KEGG" id="aplc:110976883"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008373">
        <property type="term" value="F:sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23965">
        <property type="entry name" value="GT29_ST6GALNAC3_4_5_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23136:SF12">
        <property type="entry name" value="ALPHA-2,6-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23136">
        <property type="entry name" value="TAX1-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022086253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022086254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022086255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022086258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="RefSeq" id="XP_022086259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022086260.1"/>
        </source>
    </evidence>
    <sequence length="399" mass="46154" checksum="3E860219F8EA5377" modified="2022-01-19" version="1">MYVWNVLIFDLRNMKTPHRFLLFALCYSVACLVCMTLFFDGEGSTQVKVRSKSGTTVRPSRGSDRGSDSNNGMSAKAGRLHVNWRQERTKDLFLRKGPDLALEDYQTLIGNKSVKFQCNQCAIVTSSGQLLGTGAGRQIDSNDCVIRMNNAPTKGFESDVGSRTTVRVIGHVNLRRIFANHPEAQEEFLVNASTRTDKIFMHWSFLTDIDRDPPQEYALALQLAKAYRNVSFNMFTPQKMVYAEKLFQHETGLSRSQAKTWLSTGWYTILLAIDSCKQINVFGMIYEDYCTEYPNKKIPYHYYNPSFKTECQYYHVSEVRLTSGHLFITEKAIFGRWANIHNIHFHYPRWPARSLRLGSQGVLTPFIQRYQISQNRFFSKLPYWKLIFHFSGLFYPLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y0H8</accession>
    <name>A0A8B7Y0H8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine/threonine-protein kinase Chk2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110976646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022085800.1">
        <property type="nucleotide sequence ID" value="XM_022230108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y0H8"/>
    <dbReference type="GeneID" id="110976646"/>
    <dbReference type="KEGG" id="aplc:110976646"/>
    <dbReference type="OMA" id="MLCAVQY"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22666">
        <property type="entry name" value="FHA_CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000079">
        <property type="entry name" value="Checkpoint kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000255">
        <property type="entry name" value="serine/threonine-protein kinase Chk2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="75"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="182"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022085800.1"/>
        </source>
    </evidence>
    <sequence length="524" mass="58822" checksum="864864B53C5413B3" modified="2022-01-19" version="1">MSQTNSHNTSSSLSSAGTISSMETLPTQDVVDGDFDYHDEVDENPEIVWGRLLPVGKTFLAVDLKETREQSKDEYVFGRDSSCDVAYSTPQMCSNPCFQAISKRHFRIYKEKKNSSVFVFIEDFSSNGTFLNGEKIGKGRKSPLKNNDEIALSLPKNKAYVFMDSSSDTEQEDLPEAMREKYILSKVLGRGACGLVRLAFKKGSCEKFAVKIIEKKTFSIGGSMLSNMEKTVMEEVKILKALNHPCIIAIEDVCHTDDRLYIILELVEGGELFDRVVSVKKFDELTAKVLFYQMLLATKYLHDNGITHRDLKPENILLSNDDSHTLIKVTDFGLSKFLGEKSLMQTLCGTPTYLAPEVLTKAGKTGYGKSVDCWSLGVILFICLGGYPPFTEEVTVMPLDEQIKRGYYNFPTKFWKGVSDEAIDLIKKLLTVDAHRRFTVNNALEHPWLKDDNMKEIVENLMHPPSKRMPPPQINIMTKKRPRDKGSEDVNGEKSSSGNESAKVTRLSDSSDENTRSISDVSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y1E4</accession>
    <name>A0A8B7Y1E4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110977304</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110977304</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022086983.1">
        <property type="nucleotide sequence ID" value="XM_022231291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y1E4"/>
    <dbReference type="GeneID" id="110977304"/>
    <dbReference type="KEGG" id="aplc:110977304"/>
    <dbReference type="OMA" id="DALCFCG"/>
    <dbReference type="OrthoDB" id="10037529at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034199652" evidence="3">
        <location>
            <begin position="28"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022086983.1"/>
        </source>
    </evidence>
    <sequence length="190" mass="21692" checksum="077C71E046B129EC" modified="2022-01-19" version="1">MRHKRRPRIRKFVQFVLLLILPLGVLSTQCPIDPDLDVGEPGNSYECPDTLPDGTENTYNTCCHNERPDENGDYHSCCQSPEVARAESMAKFYGMLGILGGVTGGLMTVVYVRTYCKDDTWRCLKPIKRECKKWFDLTMDALCFCGCCPKKLRRKTKKDHEIPDNKQTSNDKKAADDPAAVEVNMDEFWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y440</accession>
    <name>A0A8B7Y440_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Calcium-binding mitochondrial carrier protein Aralar1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC110977360</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L-alanine(in) + L-aspartate(out)</text>
            <dbReference type="Rhea" id="RHEA:70975"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>3-sulfino-L-alanine(out) + L-glutamate(in) + H(+)(in) = 3-sulfino-L-alanine(in) + L-glutamate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70967"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-aspartate(in) + L-glutamate(out) + H(+)(out) = L-aspartate(out) + L-glutamate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70783"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087095.1">
        <property type="nucleotide sequence ID" value="XM_022231403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y440"/>
    <dbReference type="GeneID" id="110977360"/>
    <dbReference type="KEGG" id="aplc:110977360"/>
    <dbReference type="OMA" id="AFQNVMR"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000064">
        <property type="entry name" value="calcium-binding mitochondrial carrier protein Aralar1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="332"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="430"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="522"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_022087095.1"/>
        </source>
    </evidence>
    <sequence length="675" mass="74980" checksum="5E463B934BAED5AC" modified="2022-01-19" version="1">MFHTHASCQPAPGAQTLHLVKRADPALLRQIFNKYAGAEKEGEKFMTAEDFIRGFLGMQPERNYNPNTMKLLAGVADQTKDGLISFIEFQAFEALLCSPDALHMVAFQLFDTNGSGFVSFDEFKKVYSATEVHQQIPFDFNCAFVGRHFGKDKKKELSYAEFTQFLWVLQEEHARQAFDLFDESNLGVINALEFRKIMTTIKSHLITDYVAENLVSVAGGETKHLVSFPYFIAFNSLLSRMELMKKIHSDMTNADSKSGVTKEEFLHVAQEYSQITPLEVSILFHLCCLESSTGRITMSDIDRVAPKNDLVGEMQIQQPKQEVKRTVLIQVAESIYRFCLGAIAGAVGATAVYPIDLVKTRMQNQRGGLVGELMYENSLDCFTKVVRHEGFFGLYRGLPPQLLGVAPEKAIKLTMNDFVRDRLRRKDGGLPLWAEIVAGGCAGASQVMFTNPLEIVKIRLQVAGEIQSGPRVSAITVVRDLGFFGLYKGARACFLRDIPFSAIYFPGYAHLKKAFADKDGHNSPTSLLVAATLAGPPAAYLATPADVIKTRLQVIARRGQQTYSGVLSPVCRVMMFLFFVGFFTARVFRSSPQFGVTLLTYEILQRYLYIDFGGQRPEGSETKPSTHIADLPPVNPDHIGGLRLAVATFSGVESKFGLFLPKFRNPLATVAVQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4J7</accession>
    <name>A0A8B7Y4J7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lys-63-specific deubiquitinase BRCC36-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110977892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. BRCC36 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088114.1">
        <property type="nucleotide sequence ID" value="XM_022232422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4J7"/>
    <dbReference type="GeneID" id="110977892"/>
    <dbReference type="KEGG" id="aplc:110977892"/>
    <dbReference type="CTD" id="79184"/>
    <dbReference type="OMA" id="CIGEIDT"/>
    <dbReference type="OrthoDB" id="446074at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08068">
        <property type="entry name" value="MPN_BRCC36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040749">
        <property type="entry name" value="BRCC36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033860">
        <property type="entry name" value="MPN_BRCC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18110">
        <property type="entry name" value="BRCC36_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022088114.1"/>
        </source>
    </evidence>
    <sequence length="265" mass="29745" checksum="8B1CDBAB68A84419" modified="2022-01-19" version="1">MTASCVYLAADAYMVCLTHALSTEREEVMGLCIGEIDTNRAVHIVSVIMLQRSDKRKDRVEISPEQLSMAASEAESLATLMGRPLRVIGWYHSHPHITVWPSHVDVRTQASYQFLDDGFIGLIFSCFNEEKETRAGQIQVTCFQSTNQSPEGEPPIYDRLEIPLFIIPKDTIGTSCLDALAELPKILSQEELEAYNQADCNTGTSMTDLLTTMHNGAVYTKSLCHLMDVLSGPLMQCLENRLERNQRKLESLRQLKHSLQVQLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y4M1</accession>
    <name>A0A8B7Y4M1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">5'-nucleotidase domain-containing protein 3-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110977915</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088139.1">
        <property type="nucleotide sequence ID" value="XM_022232447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y4M1"/>
    <dbReference type="GeneID" id="110977915"/>
    <dbReference type="KEGG" id="aplc:110977915"/>
    <dbReference type="OMA" id="LWARGNR"/>
    <dbReference type="OrthoDB" id="409330at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF12">
        <property type="entry name" value="FI20020P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022088139.1"/>
        </source>
    </evidence>
    <sequence length="528" mass="61067" checksum="372A973781654E2E" modified="2022-01-19" version="1">MAAVLKHFTRRRFCIASTRHLRRFSCALGQRHMRQLCTSVTDDAVGKVITDSELWNEYNTTKAYCEQFATNHCINVEPKTVFANNEVDLSDIEVYGFDYDYTLACYTDHLHYLIYNQAVENLVERKMFPSGIANMEYSPHFAIRGLHFDTRKGYLMKIDAFQHIQLGTVYRGKQPVSDEEVSASYRGTHIPESLLTQGPMSHPIKQLMDLFAIPEMALLANVAEFLTENEIDYDPEYLFTDIHNAVKEVHTSGIMHKKVVGNVGKYLETGTGIPEYIKTLHDAGKQLFLMTNSQFNFVDEGMKFLLGPDWIDLFDVIITQARKPLFFHDTTRPFRFIYRKTGMPSWARVTKLRKGKIYLQGNMEQFKELTQWDPSTVLYFGDHVYSDLVDPCLKNGWRTGGVIPELDDEIAICNSVPFKQAVTWLVLLQELIQKHQVHTDPGCQAVVQEWLRERNQVRKTTKTLFNPQFGSIFRTFHNPSYFTSRLCRFADIYMSCLGNLNSYSLNHTFYPRRSALPHELSFSNVLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y541</accession>
    <name>A0A8B7Y541_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="12 13">Homeobox protein Nkx-2.2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">LOC110977668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087657.1">
        <property type="nucleotide sequence ID" value="XM_022231965.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022087658.1">
        <property type="nucleotide sequence ID" value="XM_022231966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y541"/>
    <dbReference type="GeneID" id="110977668"/>
    <dbReference type="KEGG" id="aplc:110977668"/>
    <dbReference type="OMA" id="HHEMIAT"/>
    <dbReference type="OrthoDB" id="3137333at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000101">
        <property type="entry name" value="NK2 homeobox 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF82">
        <property type="entry name" value="HOMEOBOX PROTEIN VND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="167"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="169"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022087657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022087658.1"/>
        </source>
    </evidence>
    <sequence length="336" mass="36231" checksum="5B5A17C75411C5DE" modified="2022-01-19" version="1">MWTSPPPMDETEIAMNVKTSFSVKDILDMPQAAAVVAAAAAGEATKARSCRVGNGGSPTVALQDGATTISSHEQANMNSFYDASDNPYTRWLQTQGSDLMPYSSLGQTANSPNSTSAKSTSSTVNTTTTSNKTSPPVTTDISNGNLSGSGSDDDESANQDSSSSDPPKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASIIRLTPTQVKIWFQNHRYKLKRSRQEKGLDMNPLPSPRRVAVPVLVRDGKPCGAGMNGAASAAMAAAPCMGPKSHHEMIATTAATAPPPLQHMQAYPSQCSYAAAPYSSYSTFSGMSNNMQYSGSMAQPWTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y5B4</accession>
    <name>A0A8B7Y5B4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein LOC110978050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110978050</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088383.1">
        <property type="nucleotide sequence ID" value="XM_022232691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110978050"/>
    <dbReference type="KEGG" id="aplc:110978050"/>
    <dbReference type="OMA" id="VICSTEH"/>
    <dbReference type="OrthoDB" id="10037534at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000001">
        <property type="entry name" value="Lysyl oxidase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003410">
        <property type="entry name" value="HYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331:SF465">
        <property type="entry name" value="EGG PEPTIDE SPERACT RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02494">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00303">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50825">
        <property type="entry name" value="HYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00420">
        <property type="entry name" value="SRCR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1020"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1054"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1079"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1124"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1165"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1203"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1234"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="125"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="237"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="16">
        <location>
            <begin position="347"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="HYR" evidence="17">
        <location>
            <begin position="536"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="14">
        <location>
            <begin position="610"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="13">
        <location>
            <begin position="817"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="15">
        <location>
            <begin position="1018"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1262"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1276"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50227"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022088383.1"/>
        </source>
    </evidence>
    <sequence length="1320" mass="143912" checksum="9CB93B1BCB759FE3" modified="2022-01-19" version="1">MIQIRPLRAAFVKCEEESNFPVRLVDGSSNTDGVVEIFFNDRWGKVCSYGWDSADASVVCRQLGFHGLNVSVIYNRQSQTVDYLMNVDCTGDEAKLADCGYNGWNAHCFKYAGVMCQMAAKEYPVRLIGGNSSTEGIVEILFNGQWVNVSSNEWDDAAAGVVCRQLGLHGPSKAVIYLHTPSSMQGSDGVFLEDVRCNGDEQRLADCFYARWGIEQFFSNERLGVICSTEHYSVFPIRLIGGLTPKSGLIQLFYLNQWGVVCDENWSEAEAKVVCRQLGFEGHSLPTVNSVSWQSDSDPVYQTSFHCLGDEESLTSCMRNSGKHRSSMFCYQKIGVVCQESVDFYPIRLAGGLSYEAGRIEVYFQGYWGIIQDCSDTNNWGIEEANVACNQLGFNGARASVFHSIYGDGTGLILMESVDCSENFEVFGGTCPPPEAVPRPNGQPTIDVIAPLGQSVASVFWTKPTLVLPLNHSTESSRCVPADADSSPYPCQSGSSFNITSQFAISHGRDTAVQYVVTDLDEVDSNFKCTFFVSVRDDEKPTITCPDNITKVAEYGFQYITANWTEPVGTDNSDIVSTISNVPHSPPIQLGFGIHVFTYTATDGSLNTNFCTFAVTVKKMKVGSCPSDVTSDTTHGLLTWPVTEAGSHAESFQRCPIYTERAGWAKAVRHCTFDNLAGSATWEAPQILSCGENRSRVTVEDVAQIPISRHNVLEVAKFLAEKSYKDWSTQRIDAVVEILNNITRLGPDGEPNVTNAVIDTVDNIAKALATFEQSQYLSKESLVSMLRTVQKHVSATLARKGVVHIQKDSIHVEAVSANLSWARNGLSFILEDGLTSEQRGSTQAGRSRLVGSEVRVYGGEVLQSHSVRAAVTLPGNMVKRLPERDGNTSLPHMNVSFIIYADDTMFPSAFVKGSQSGNQSAVVVPGPVISLAVEDVTLVNLSEPVVIEFETVASSSTESATCVFWDFTLEGGVGDWSSIGCEFQGLTNGRYTCLCNHEAIFAVLVELGEEFQTNRGSLDLIAQISCIGSTSTYLIVIIAYLFLRKARAGKAGHVFLQFLFSLLMIYAVFLAGVNHARHLRSGCVVVAALLHYLPLATLMWTAVEVRHIYNSMLHGSSTDSSSCVILTSLVAWASPLIVTGITVTLALDHYGSVDSCLLVPGLPLYLGFLVPVGLILTHNTITTIAAVKVNFCSAEDGLPSSQVVARLICGTLTWVLFLAILCFGFLLIYSTRSVFSIVFSALNFAEIVVVCTLACVHRTKETPISGTQKGPQEGSKEEDEEDKDFCSEEETPSSLSNAVKSVDCQGTRVTSHTEIALEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6K2</accession>
    <name>A0A8B7Y6K2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110977947</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022088187.1">
        <property type="nucleotide sequence ID" value="XM_022232495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6K2"/>
    <dbReference type="GeneID" id="110977947"/>
    <dbReference type="KEGG" id="aplc:110977947"/>
    <dbReference type="OMA" id="ETVITIC"/>
    <dbReference type="OrthoDB" id="6286464at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
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    <feature type="transmembrane region" description="Helical" evidence="3">
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="386"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="856"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="917"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="942"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1011"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="17"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="583"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="772"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="773"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022088187.1"/>
        </source>
    </evidence>
    <sequence length="1047" mass="111817" checksum="62E34F7AD677028A" modified="2022-01-19" version="1">MAAADKSSPAKEGGRRGVVIVLAGHVNMALMLGLQRCCGVLYLSWQSEFNTTARETAAVQSLLSSFSCFSVFPGGLVTRRFGARVSGMIGGLLIALGLFCSCWVSDIKQLYIAATTTGFGLGFSFTSVIDAVATHFKTRYKTAHAVAYSGMGTGIIALPPLLQLLVDSYGWRGAVLILSAIMADIMVCCALFQPPARRNPGSPRRQIKQPGAGLGCSDADASGSSKKDCEIRQGDGAAAEAGPVPGESLLETSPGLKDGEGDTQEWILPTHRETVNPKASLWKKVSAFLGLSVFVKSYRFTMLCLVQTEVNAPYTGFIQFIIPRAESTGVSPSAAAFLISLLGIGGLLGRLGNGLLISWKVSAETVITICFLSASLSSLLPVLDGYAWLAAASFVQGFTVGAFHAIQIVLIRRYVGLTRLVLSTGLCHLVVGIGVLSGPVIAGWLFDVTDSYKTIFYVLAGMYGACALQMLLFPMLKRAEPGIVVQPWDEITASVLIPWNKSTGLQDGNLFYIGLCTATVPNVSVGNFNFATRKTETYPRGITALLLSFVGRICSVSNMAKPSHTGRRTGRGAAEEPPEGGRSIVVVIAAHLVLAIVLGLVRSAGVLYLSWKEDFDTNDKETAVVQSILSSMSNFGCLFGGPLTERFGSRVSGIIGGTLTCIGFFCSCWVTDIVQLYLTMFVAGTGMGICYNSLVVAVAMYFKRKYKVANALMSSGCGTGIMAGPPLIQVLLEHYGWRGTLLIASAIAANIITLCALFRPIRAPRKTPLRMASRYEGETPRKGVANDRRNSDEDSGRDVGALEVEGAHTVHGPHSKSRTRHVSLKMVSKNCNPIVNLMRRLSVSFGFQLLVKSYRFALLCTLQILYYCAYMGFLLYLVPRAQSLGVAPSSAAFLLSILGIGSLLGRLGHGVFVSWKISAEHVTAISMVIAGISLLITGLESYYSFAIASSLHGFVSGYFSAVVLILIRHFVGVKQMAVASGINQIFVGLGTVIGPIVAGAILDLTSSNYQAVFYILSTAYFICAALMFLLPKLKRVEPGENVEPTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y6X9</accession>
    <name>A0A8B7Y6X9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin-like phospholipase domain-containing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110978004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088317.1">
        <property type="nucleotide sequence ID" value="XM_022232625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y6X9"/>
    <dbReference type="GeneID" id="110978004"/>
    <dbReference type="KEGG" id="aplc:110978004"/>
    <dbReference type="OMA" id="DKIACGW"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF7">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="11"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022088317.1"/>
        </source>
    </evidence>
    <sequence length="324" mass="36069" checksum="DEB5EDC29F9CA3F0" modified="2022-01-19" version="1">MGEHLTPPFDLALAGSSFFGIRNVGVGQCLLDHGAVVLRHAEHFGGISSNALVAGVMATTPANLAKYLYALYDIVDEVAPLPFGALTPGFDFIDRLRSLLNENLPSDAHEKATNRLHVRATALSMIDKYDPVSVHDVDQGTSSSVRARGPKQFEIGDRCWKIGDEVEIASYRSREELIEVLLGCIYIPWFPSWNPPQYDGRFLADATLSRTSNLPVNVDFSFRPANQLIRISPDPKSRATMRDKIACGWVDTTGQRFDISALEMFRTGNGLYPPPKGHLEAYFADGYEDATRFLKFYHCYEDNPKGLGPRRDQYAAIHSVDDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y7I4</accession>
    <name>A0A8B7Y7I4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein DP71L</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">MyD116 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110978466</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Interacts with the host phosphatase PP1 catalytic subunit (PPP1CB) and recruits it to dephosphorylate EIF2S1/eIF2alpha and therefore restores the host translation that has been shut-down by the host. Also inhibits the EIF2S1/eIF2alpha-ATF4-DDIT3/CHOP pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts (via C-terminus) with host PPP1CB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP1R15 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the asfivirus DP71L family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089183.1">
        <property type="nucleotide sequence ID" value="XM_022233491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y7I4"/>
    <dbReference type="GeneID" id="110978466"/>
    <dbReference type="KEGG" id="aplc:110978466"/>
    <dbReference type="OMA" id="SQFINTE"/>
    <dbReference type="OrthoDB" id="5976067at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051246">
        <property type="term" value="P:regulation of protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039502">
        <property type="term" value="P:symbiont-mediated suppression of host type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051254">
        <property type="entry name" value="PPP1R15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019523">
        <property type="entry name" value="Prot_Pase1_reg-su15A/B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16489">
        <property type="entry name" value="GH11727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16489:SF12">
        <property type="entry name" value="GH11727P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10488">
        <property type="entry name" value="PP1c_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="7" id="KW-1090">Inhibition of host innate immune response by virus</keyword>
    <keyword evidence="8" id="KW-1114">Inhibition of host interferon signaling pathway by virus</keyword>
    <keyword evidence="10" id="KW-0922">Interferon antiviral system evasion</keyword>
    <keyword evidence="9" id="KW-0426">Late protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0899">Viral immunoevasion</keyword>
    <feature type="domain" description="Protein phosphatase 1 regulatory subunit 15A/B C-terminal" evidence="14">
        <location>
            <begin position="980"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="380"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="583"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="692"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="759"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="924"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="762"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="799"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="858"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="939"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022089183.1"/>
        </source>
    </evidence>
    <sequence length="1057" mass="116519" checksum="EDD98D98E6955D13" modified="2022-01-19" version="1">MDPDLPNRPSCPSIWSKRCHLVRPTTGERQQGWGFSKSRNFDRRGKAINSSRPIHSTNCIRKPPSLLRLSSTGDTVDETADFSSFQPSTLRRSKSSFRGPGFWGNIAKVARSTNVSSSRLLTAKGFTRESPVEMAGEVDLSILMEKFDSSPSKMERLGPLENDIDSVPVVAYPLEGGLRGFVKEGIYHPFARNPSHQVKMPRQANPAVVETRSSSVHTFPVCNGGPFWHPHGRQHPHPYFSRNHFTPNQRRNFTMASVQFWQGPSSHIAAVSSLDTPILQCESHRRRCLSAQIRESAVLRNWIADPSTRSQFINTETIAARLVQSHDADKFQSQHTCTGHHAGRNSMMQSACRTQMTQHSQNRNKATGCVYTGNAHQAHRRPLTTTSTGITPKQSCYSPKKSVKQPVSKCFSRDKLKHPDGKTAKLSDQQAEKPHKVYKPETPVGVLDHVTDEVKDLKIQAKSDQGGGIPESRDKTCLNDGHACTCGLQSQTCVTSSVDCKHHEMSPYTTAGRVPPDLTGPKSADNETSPFRDTCHGLMARSLSGGKSHLLEPDEGCVAFLDELPALEKTCLTSEDDYLDEGETRQNHQNAVSGLSPSSPATKSPPELPQTCGSQPSEPEDELSQNRKPLHSSLAFLLAGVTDGDNDFSDSDWDSAGSSPPSDSWDFLKCCDDPYNPLYGWRCARRCEQGDVEQGAESKLDSPSGGDDERDSGISSLQAHQDDVAEISPAESESWDEAEPSFESESTSWCQQIESLHAKSECPNSSNDSNHSSVPDSLQSSNENHAASDLSVQHCEVQSKVQDNPTTSLSCLSKTDGPQSISPDEVKSGKILPPRKCIFEPEKLHPSVLFILGVGESDSDTDCEDDDDDDFDNCESGSDDSAWSSLQPCFDPYSPLQGWRFHLTTPEKLQEVNAAYNKLAPVKETSSANLSTSEDDRGNSCSGQTLNQFSAKNDARPKLKRASSTGCLWVPCDGSGPGRPSQNKKVHFCEEAPMVISFEVPSWSSEYSDSRRGPWQEMARDRCRFMDRIRSTEDKIGHVFAPDHRLKVQQRLQTQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y841</accession>
    <name>A0A8B7Y841_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Telomerase protein component 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110977797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022087926.1">
        <property type="nucleotide sequence ID" value="XM_022232234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y841"/>
    <dbReference type="GeneID" id="110977797"/>
    <dbReference type="KEGG" id="aplc:110977797"/>
    <dbReference type="OMA" id="PLPAAKW"/>
    <dbReference type="OrthoDB" id="2325716at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051191">
        <property type="entry name" value="DCAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19860:SF14">
        <property type="entry name" value="DUF4062 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF4062" evidence="4">
        <location>
            <begin position="53"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="317"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022087926.1"/>
        </source>
    </evidence>
    <sequence length="1055" mass="120578" checksum="DA61F0C2F02D0C0E" modified="2022-01-19" version="1">MGCGGSRSMQVPSGPSDYKYIVQQTWENVGKTLERGSSRKKLVIKRSGWKTVRVFVSSTFKDFHAEREILVKEVFPDLRQWCEKRRLHLVECDLRWGVPKDTSSEETLRLCLGEIDRCYQDNIMPFFLNLTSERCGWIPTPYDVPESLAKEYRWIPGLSVTEMEILHGAYRIDNPNSLFMIRNSSFLKNLPPEYEKDFVDPNPIAPHKLEMLKQMLKSKLRDRVKWYDCEFAGIDEDGKAEFSGLNDVFSKEVFEFFKRRIEAQYPLVDASQDPYQQAKEAHESFLKSRGQSVLGRNAILEKIEQYVIDLGQDKALTITGGAGTGKSSIMARTADVAQTMAVNKKIPGGGEHGWHVFYHFVGAVPGSTDLEKCLKRLLKELNQVNEATMPKNLEAACQLVCSVLSNPKTAPVIVCIDALNQFDDDKSSTLLSWLPRKLAPQVRVILAMINDTPPHKSLMERPNKPQEIVVTPLDMEARKEIVTELLGTYNKRLDAAQMESLLAKESSQNPLWLAVACEELRVFGLFDRLTDKINNMADGLLELLEQVFTRFEQENGGTLLSATLCLLETSATGLLETELLKILGDEDNLLPREKDSETGKDKGAEKKAKDVGPLPAAKWAVVFRALKPFLRPFGESGEGRLDFYHRALSKAVRKKYFSSESDSPVSDQLWWHRKLAHYFDESDHVDRKVEELPIHLLKLGDTQRLTAFLTNWDVFDRLYNEDYSTLLLKYWREGHGQGWQTMMGNNYRENLEKLAADDGTSKEVLAKRYEQISRVINQSGEHGAAITLLETAMELEEELGSRPERMVELYALACTVYDDKLKLYEYVDPSQLRDLRPVISFAHKSIAIRETLEGPVHKYKLGRIKIQLAFNLQSWVECGADNTLSVEEAADEGRQQIESAIEIFKELDDIGHLADAIMTKGVLEERGSEEQKKYYLEAIDLCLQAYGEYSVLASRILLNTGIMYEDMGKYNQAYDYYLRWQDVCEEVFGYHHPRTQRCRNCLNEPMYRRIKQARAAQEANRQARDPSQNQYADDGVDLDDDDLLSDDEDYDEDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8E9</accession>
    <name>A0A8B7Y8E9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="13 14">Uncharacterized protein LOC110977848</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13 14" type="primary">LOC110977848</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the interleukin-1 receptor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088025.1">
        <property type="nucleotide sequence ID" value="XM_022232333.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088026.1">
        <property type="nucleotide sequence ID" value="XM_022232334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8E9"/>
    <dbReference type="GeneID" id="110977848"/>
    <dbReference type="KEGG" id="aplc:110977848"/>
    <dbReference type="OMA" id="TDSCYFW"/>
    <dbReference type="OrthoDB" id="10071510at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052598">
        <property type="entry name" value="IgSF_CEA-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337:SF20">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44337">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665517" evidence="9">
        <location>
            <begin position="23"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="162"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="10">
        <location>
            <begin position="333"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022088025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022088026.1"/>
        </source>
    </evidence>
    <sequence length="481" mass="53778" checksum="13BADE46C0F258A3" modified="2022-01-19" version="1">MHSASPWVLAITILLGSQVGLSVGICKPDFPDRQLKPMFVQPKSDRLELLPGNSASLICEVDRLVDPENPPTAGLLIWWCNSTYPICHQQAQSLSTFDPKFLSGVQSAAINASHLRSEFNLTNVVPSQADLYYCVAYTQDESSSKCPGSVVVDIVIKDESKPKIISHSSGISVSEGSPFNLTCTAEGYPTPMFTWTKDGEPILGGVDGVFKKDKANVSDKGTYQCRAVNKFESSEWSPDIRVKVNGKEADGLSKVKQALLITAVVVFAILLVIVIVRILKLRSNGHMTCFHFERTTIRGNNSKVIKADTVHVHSDRRGSRLSRGDSSHERQTFLHDVFIHNHSSDNQFAHMIRAKLQNQESHLKVGLWSEVERPDRSSSRNKLLRLRLLNCTRIVIVVSEAYLKHDYHALTSALAKSRAAPESLRSKIIIVRVLEESKLPKDLAKDVMASMEYNVDTDSCYFWPRFLKVAMPDQKEILYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y8N3</accession>
    <name>A0A8B7Y8N3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Protein phosphatase 1K, mitochondrial-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9 10" type="primary">LOC110977776</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022087933.1">
        <property type="nucleotide sequence ID" value="XM_022232241.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088020.1">
        <property type="nucleotide sequence ID" value="XM_022232328.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088106.1">
        <property type="nucleotide sequence ID" value="XM_022232414.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022088184.1">
        <property type="nucleotide sequence ID" value="XM_022232492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y8N3"/>
    <dbReference type="GeneID" id="110977776"/>
    <dbReference type="KEGG" id="aplc:110977776"/>
    <dbReference type="CTD" id="152926"/>
    <dbReference type="OMA" id="CHTHMKK"/>
    <dbReference type="OrthoDB" id="416093at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="97"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022087933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022088020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022088106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022088184.1"/>
        </source>
    </evidence>
    <sequence length="373" mass="41686" checksum="20BE4D299705C0F2" modified="2022-01-19" version="1">MFNSVSLSGLSRVCMRNVLKEVKLNLRYSSLPRTHLGKGKTVPPTCTCIRNCSSGDHSNRPPEWDTYGTWENRIEEPILLQQSIKHGIPIPKISLSNVGQESLIGRRLTNEDRIRVGELAPNLLYFGIYDGHGGAVAADFASYSLEHHVAYWLTKEHDLQVVLRQSFVDLENQFARYLHMELQDPALENSGTTATVCLLRNGNELVVANVGDSRAILCRKGRAVRLSRDHQPEVDSERERIEASKGFISWNSKGHPLVNGALAMTRSIGDGPLKRYGVTAQPETKSVEIKHSKDSMLVLVTDGIISVMTDQEICDSINQCHDPPSAAYFVADQALQFGSEDNASILVVPLARWGYETGKSSMYTMRWFEWSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9D9</accession>
    <name>A0A8B7Y9D9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fatty acyl-CoA hydrolase precursor, medium chain-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110978018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022088336.1">
        <property type="nucleotide sequence ID" value="XM_022232644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9D9"/>
    <dbReference type="GeneID" id="110978018"/>
    <dbReference type="KEGG" id="aplc:110978018"/>
    <dbReference type="OMA" id="WPEYGDT"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003990">
        <property type="term" value="F:acetylcholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006581">
        <property type="term" value="P:acetylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019695">
        <property type="term" value="P:choline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034890973" evidence="6">
        <location>
            <begin position="21"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="7">
        <location>
            <begin position="21"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="758"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022088336.1"/>
        </source>
    </evidence>
    <sequence length="828" mass="91138" checksum="44FFA29DBD819A85" modified="2022-01-19" version="1">MAQLSLFLAVWALVAYKVNANPVVNTTAGEVHGFKREVNGTTCYIFAGIPYAEPPSGTLRFRAPVAKTPWRDVFNATKYGPSCPQDAARITAFLPDQIQIPSAAMEISEDCLTLNVYTPSVNLSSNSNLAVVVWIHGGSYRSGLGSAYDASYLAVMGDLVVVTMNYRLGPFGFLYTGDEHAQGNFGLLDQQLALQWVQDNIQAFGGDPSMVTLVGQSDVHGAPTLHMFAKGSRALFHRVVAHSGVVGPEGLKESAEAIADTKLLAQLAGCPSKSSGPLVECLRRKQVEDIVKTVDPYLSIQKKSSFAWRPVSTSEVFVRQPGNSMTYDFLSIFNSGDGSVALELMKDLFPEFNLTKGSTEGQWQQWLDVNIDRPKLIDKAVEQQYVRRNESIARMRGLFDAQFDRTFCRYGVESLRTLQPLLSSRRLMIFDHRSSSESRFPEPYDLVPHGAELPYVFGLPFNDSWNFTDDELELSRRMIRYLSNFAKTGDPNTDDGQDSSNTSQTWPEYGDTETYVTTNVLQEKIAQRYRSDRVYFWCEYLDELEASAEAACPARPVTSASSCEDPVIGKGLGFALTVGQAETLIEAFIFLIIGLLCVSLLLVGAMCGYKYRHRAISQLDIMQGEEGALNKATEAWIVNPFSTEDGSRNAITGSASDHTYQLLQRRPPSRVTFSEVDVEVLPPPPDNLITDDTQDGLDDKIPSPPETVGDEDEDADDSPPTEELEELNLSDEFHIDEDGNASSPATTVSAGVASHEETDPDEGPTDDDDDDGDANLEADSEPTDDGDIPESEEPAGAKPDRAPLDDFHSLNRRLSSEFYNRLESALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Y9Q7</accession>
    <name>A0A8B7Y9Q7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Scavenger receptor cysteine-rich domain superfamily protein-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110978418</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022089105.1">
        <property type="nucleotide sequence ID" value="XM_022233413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Y9Q7"/>
    <dbReference type="GeneID" id="110978418"/>
    <dbReference type="KEGG" id="aplc:110978418"/>
    <dbReference type="OMA" id="LNFAYHI"/>
    <dbReference type="OrthoDB" id="9935125at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.250.10:FF:000016">
        <property type="entry name" value="Scavenger receptor cysteine-rich protein type 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19331">
        <property type="entry name" value="SCAVENGER RECEPTOR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00258">
        <property type="entry name" value="SPERACTRCPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0768">Sushi</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034294432" evidence="12">
        <location>
            <begin position="18"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="13">
        <location>
            <begin position="31"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="15">
        <location>
            <begin position="129"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="14">
        <location>
            <begin position="238"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022089105.1"/>
        </source>
    </evidence>
    <sequence length="429" mass="47480" checksum="704D013F6C99DE7D" modified="2022-01-19" version="1">MDVWWSVISWALVIVSARQFLIARTQMIGDLRLADGPAPNAGRVEFYLGFRGWYSTCDASWSIDDAIVVCRQLGFPGAALARNNNHYRGGAGVPLARDWECTGDENRLQDCKFTPKQRCLDTVGVVCQAPGYLGCYSDPSGSFNSRLRDGFVALPSMNVSACREHCRNSGSLLAGLKNGKECYCGRFYGAVLPGDKLSDRQCQMRCAGNEEEVCGGSRSQLRSVTALDTISVFDVKLGRCDPPTQLANGRVLGNKYSYGDVIHFVCGQGYQLRNASAASARCVMVRDGTGRTVGWEQPVPACQVAIDSKTRMTQDDKFTGYETIHRQHTLLAVLACLVAILTTAILFILVKRRIARKRATRSNPDPPPCYQDLVMDYEPIMDPKTGHYPVDRGSCYQTLKPPVPNRSPRYAIRVNVPGHISYPQELWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBD6</accession>
    <name>A0A8B7YBD6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Exosome complex component RRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Exosome component 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ribosomal RNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110979247</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Homodimer. Component of the RNA exosome core complex (Exo-9), composed of EXOSC1, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8 and EXOSC9; within the complex interacts with EXOSC3, EXOSC8, and EXOSC9. The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with GTPBP1. Interacts with ZC3HAV1. Interacts with DDX17 only in the presence of ZC3HAV1 in an RNA-independent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022090559.1">
        <property type="nucleotide sequence ID" value="XM_022234867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YBD6"/>
    <dbReference type="GeneID" id="110979247"/>
    <dbReference type="KEGG" id="aplc:110979247"/>
    <dbReference type="CTD" id="56915"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000012">
        <property type="entry name" value="exosome complex component RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="14">
        <location>
            <begin position="34"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="15">
        <location>
            <begin position="157"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022090559.1"/>
        </source>
    </evidence>
    <sequence length="242" mass="26483" checksum="8BCF4294874346C8" modified="2022-01-19" version="1">MPLDIVITRAFSLDIQLKFQFFSMNSSDLDVDPELRAASSEQSLLSRPDGSATFTQGDTSVMAAVYGPADVRLNKEIIDRATVEVIYKPKSGMPGIREKSKEQLIRNSCEAVILTTLHPRSSITIVTQEIQDSGSLLSCCVNASCMALMDAGIPMKCLVAAVTCMLDSDGRLVLDPTDKQAKDAQCLASFAFDSRHKKVITSSFQGSCTVQEYQSLLASCQTASQKVFDFYRTSVEHRLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YBL3</accession>
    <name>A0A8B7YBL3_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Regulator of G-protein signaling 22-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110979284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022090639.1">
        <property type="nucleotide sequence ID" value="XM_022234947.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110979284"/>
    <dbReference type="KEGG" id="aplc:110979284"/>
    <dbReference type="CTD" id="26166"/>
    <dbReference type="OMA" id="LMRSWYL"/>
    <dbReference type="OrthoDB" id="10013157at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08726">
        <property type="entry name" value="RGS_RGS22_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08725">
        <property type="entry name" value="RGS_RGS22_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042651">
        <property type="entry name" value="Rgs22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048074">
        <property type="entry name" value="RGS22_RGS_fourth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048073">
        <property type="entry name" value="RGS22_RGS_third"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46583">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46583:SF1">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="1219"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1360"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1360"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1449"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1528"/>
            <end position="1543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022090639.1"/>
        </source>
    </evidence>
    <sequence length="1543" mass="176511" checksum="A5EDED809550F2AE" modified="2022-01-19" version="1">MPQKKISIVPPVVTADDLEDFLATDDLFVDYFNAFLQLPTFPEPLIFNKEKRGFEVVTSAKQALKEKIRSLVRSQQKPNPIYTATKKFMKSKLPLGAKLPSGPLYTEEDFDVKTSFMVQCLNKEQGIKWIKEERLPAFLQSDTYLEFRLAKLVSQVEIAAKDSDVPIHLYVDPTYTPFAIEKPPVVEQPKVDEQGIAMRQMFVCMGEAHPTQSKEWFSDVKMKSSTTTTNSVQPRSSDGFSSSRPASGRPLSGRPLSSSMSIWDQVTADSGIGSPWRQDSFSNSNFDPVSLDDIPNSDKMFHSPHRLRSPPVWRPPIGDDSCMVAENVRNSGSYSGPVHVATVESKPKVSAEESLDEVEEDEKLSTESGFDAESQQLNVSDNENEEDLPELQPQPIRVSTLEDMATVVVSFAIKSAITMATDLSQDEIDTYIDENILKALDVCSADLTEEALHTMEVSLSMEQKRPSILKNGLDVQDDLRTNSRISLATVGQDDVEEDSLFDSDNENDTDEIKDPFFSKLRYSFDLSNKRGLDGFKRFLWGTAGEKIWNLWLDVDRGCMIDDTEVQQHFLGQLRDKYLKSGGVCELPREVLQSLRLDAPSKWTSIDRLAKIQPNIIAPLLLYWAPRFLMREMYTGSSSSVATTNQIYNYQKLLNNSSSSSSHPEPRTVTLLPLRPKTCWPKLRHSIALPTEASNRRKTSPSPPQSRQSQHSKTLPSLPISSLMTSVTPKKPTHHSKTASPSTPRKITISIGSKMKPSPPTSPPPVDSRSINKNLSSRTASADVASEILEQGDARFGGSSGMNQERSVTIGAEEIVGEKEQEKSQARPNTPYKPKRPSSASSTSSSVATEESEFLGGNRMESLLEGLYHEKKAGGFFMAYLEKLDNPTLINCLSCWHELQDYHALFYADVFDSFSLHRKAQAINSKYIVHCCFYDIECSSAVRAQIYREVSPPFEELFDGAEEHVLEMLVKPWSQMKGSDMVLYNKIELISEERQLDAMNTRQLKNLTRRGFIKERISTPDFMLDEDDESKQEAYYQALREKIPEEFRDYDFNKLIHNRLELEHFRNFLEDNYAITDLMCWMDIESFRRTPYLDANKRDTKAKDIKTRYLNKKYFFGPNSPATRPQQNLVMQAGGGWGKLLLDRPPDPILIEAQKYVRQRLERKWLPMFLQREDFQERQRPHIKMEDVVNDVMNAKKLRSMAIYRILEGRWVSSSRDIIAFRQALMNPVTCSHFRKFVSVKGDNLENDVLFWLEVQKFKDMYHSHSDESIIQQKIQAILRCFIMSEIPPNLHIDITPEMAEKIMDKRPREMGPYVFRETQMTVFKVLFQHWADFQKYRTSLSEEKMLYDLERKRKKLRRKEMEMRRMEEEKEARKDEDDQNSIGSKSLSRRFSVFAEFLDEGEDEEDYEGQEKVHWKYSDYMTALDREQKLLHGDDRASSILSAIDSYTEEQNSQARSSRTPQSEQGTDSSDKGSKGRYKTRNKADSQPQGKEVKKKVTMNIPTKVESQGSLKKLANGKEVLLNGHQREKGKKRTPAVNGSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YDN9</accession>
    <name>A0A8B7YDN9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trypsin-2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110979199</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090490.1">
        <property type="nucleotide sequence ID" value="XM_022234798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YDN9"/>
    <dbReference type="GeneID" id="110979199"/>
    <dbReference type="KEGG" id="aplc:110979199"/>
    <dbReference type="OMA" id="SKSANWQ"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000166">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050127">
        <property type="entry name" value="Serine_Proteases_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264:SF65">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24264">
        <property type="entry name" value="TRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034869232" evidence="8">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="22"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022090490.1"/>
        </source>
    </evidence>
    <sequence length="258" mass="27302" checksum="EF4624D8893D1ECF" modified="2022-01-19" version="1">MNFFILLACLLTVLTPALSKLIVGGKESKPNSRPYQVALYDSKSANWQFCGGTLVNERWVVSAGHCAGGTVYVGLGYHDKYDNTQTGQQLIKGTWYRHPGYNSYLDNDISLIKLSSDADLSSPKIETISITKSPPAAGKNLLVSGWGALQSGGYSSRNLMEVAVQADSMATCRNAYGSSAITDNMFCASASGKDACQGDSGGPIVSNYGASSHKPGTILEGIVSWGYGCAYPGYPGVYTTVGNYCDWMAQTSGGDISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE19</accession>
    <name>A0A8B7YE19_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein LOC110979757</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110979757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the menorin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091498.1">
        <property type="nucleotide sequence ID" value="XM_022235806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE19"/>
    <dbReference type="GeneID" id="110979757"/>
    <dbReference type="KEGG" id="aplc:110979757"/>
    <dbReference type="OMA" id="HGVNSWP"/>
    <dbReference type="OrthoDB" id="413402at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057489">
        <property type="entry name" value="Menorin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019356">
        <property type="entry name" value="Menorin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184:SF6">
        <property type="entry name" value="CONSERVED PLASMA MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21184">
        <property type="entry name" value="MENORIN (DENDRITIC BRANCHING PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25161">
        <property type="entry name" value="Menorin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10223">
        <property type="entry name" value="Menorin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Menorin-like" evidence="4">
        <location>
            <begin position="155"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Menorin C-terminal" evidence="5">
        <location>
            <begin position="443"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00044953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022091498.1"/>
        </source>
    </evidence>
    <sequence length="626" mass="69618" checksum="7423AB3771181465" modified="2022-01-19" version="1">MVEDTSPAAAQSKAPDRKSRRSPSGYSPTSARSTLLALPKTYYLAPAVAAAVPCRKMRLGGRGAMGRYCRLLVVLIVCSTVVSMILFSRLWWLGQELTGGLNGLFASETRKLMDPFEEEFKGKDRMPPSIESMEEKKKSHTGDALLDYYLTMYIDGKEITWYSEVNNRDKLMEVMKDYLAMMLEADVQVRWDDVSKKKNGTAVISPKPTTPSDITLSDWLTIVAHYSNKGVKLNFPDTKSLMYGVPVLSNMKNILHAPVWVHADILPGPNGNTVVSVNVEDFIKMTRSSLLPKLSLSLGWSSAWNPDPVQQRYTWQNVIAMARACALIRAPISFSVRAVFVSKSTRQLKWLLSLAKRFTVTVWADKYDIMPVAELAYFRQVMDRKRVFYNLPASFMENLKAVNPITKAVGTEGEEDQGPKWDRNLWDPVLIHDNSLAFLGKEQAVLDGPGSWLVSKVPYKAEMKTSHTTVVSGKVQFVDTEPATPSSNSGLDVYIRNSGVNPPLPDQVQGIRLRILQDGSLQLSPVNLNQAGAFKLQSTAKLPASECYSFQLVDKGDGYPLYCIVKLWQCTPGESTDMDPATTSVGLHLNVAYEMNKQLFYVAVNGGSDKNAVVLEELAVDDKAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YE40</accession>
    <name>A0A8B7YE40_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC110979274</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022090660.1">
        <property type="nucleotide sequence ID" value="XM_022234968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YE40"/>
    <dbReference type="GeneID" id="110979274"/>
    <dbReference type="KEGG" id="aplc:110979274"/>
    <dbReference type="CTD" id="286971"/>
    <dbReference type="OMA" id="EHREWGV"/>
    <dbReference type="OrthoDB" id="9993460at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF198">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="14">
        <location>
            <begin position="116"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="13">
        <location>
            <begin position="257"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_022090660.1"/>
        </source>
    </evidence>
    <sequence length="534" mass="61295" checksum="439CDD3AB3DA929B" modified="2022-01-19" version="1">MEPSLRKRDRSTTKTQQEQAQSLSKKSSQIKGFRLKYVIFFLGVLFGAIFLGTYFLLGAVGIGHDTLSDILSSQGSFVRGDELSRGRDELNRGKPDDPISADVKPVQKQSSALSLPTIVWWTDKLFPHFQGKNTVKIECEPSQGGQGTCLVTTDKSVLSDPLARGVMFYGSDFRAYEAPLPRLPWHEWAVIHEESPLNNQIFSHAVMMSQFNHTSTFRRESHYPITTQHIKSLDYLTERQPVPISMKNKHRETLAPIAYIQTHCNVPSDRDRYVKELMKYIDVDSYGKCVNNKKLPENLQDPVESMDAKEFYDFIARYKFHLAFENGICEDYITEKLIRPFHVGCVPIYRGSPSVRDWIPDNHSIILVDNFQSPKELAEFIKRLDKNDKEYLKYLEFKNKGISNQLLRHTVERRVWGVNDWRKPSFINAFECYLCERIVERVEAERAHERDPSIPLLPPRVADGNHAGCPEPSVSLGDMSGVGRGEDIHFWKEDYWSSKDQALALKRMSEQGATDSSKLFEELQRMFTEGALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YEB5</accession>
    <name>A0A8B7YEB5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Perlucin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110979338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022090740.1">
        <property type="nucleotide sequence ID" value="XM_022235048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YEB5"/>
    <dbReference type="GeneID" id="110979338"/>
    <dbReference type="KEGG" id="aplc:110979338"/>
    <dbReference type="OMA" id="NINDHEC"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 11 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034463612" evidence="6">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="7">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="8">
        <location>
            <begin position="190"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022090740.1"/>
        </source>
    </evidence>
    <sequence length="274" mass="31077" checksum="A80E6277461B1F02" modified="2022-01-19" version="1">MKFTRVMIFALTVIILVVVAVGMDTCPSSITVQAPCPPSWQSWRHSCYRFTDEPANWDQSKLACQTMGGKMAAPYSQEENEVIVRMAQRQNINHLWIGCNDREKEGTWVCEGQGRGEPYFNWQPGEPNGHGTENCIEFYQPYYGGGSLNDNNCNILFRAICVRLRRQTSCLHCPIQPACGYQPHRARHYCFATDTDGQLLNSCLVDHVIRKFVTMSNPSCTSACIIEPACLSFNIKYNDEGQKICQLNNATHCDDPDNFQDIRSFCLYAQECVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YET1</accession>
    <name>A0A8B7YET1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Survival of motor neuron-related-splicing factor 30-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110979534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022091092.1">
        <property type="nucleotide sequence ID" value="XM_022235400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YET1"/>
    <dbReference type="GeneID" id="110979534"/>
    <dbReference type="KEGG" id="aplc:110979534"/>
    <dbReference type="OMA" id="CMAVWSQ"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20399">
        <property type="entry name" value="Tudor_SPF30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46297">
        <property type="entry name" value="ZINC FINGER CCCH-TYPE WITH G PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="7">
        <location>
            <begin position="75"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022091092.1"/>
        </source>
    </evidence>
    <sequence length="240" mass="26802" checksum="A752E63D8AE19388" modified="2022-01-19" version="1">MAEVSEDWQTNLSTYRAQLQQVEAALTNDPENEELIKLKADLQDVIELTLDLIQAGPGAKSEGDEVEKEMTETSSWGVGDNCQALYSEDGLYYEGKIDEVHMDGTVTVTFEGYGNTEIVQISKLKPSEQARGSKRSGDEADLNPKPLSKKELLAKRREYKKRKTQKKLEKLKQMEQKHEEQKNSWLNFSSKAIKSKKGMTKKSIFASPESSTGKVGIGTCGVGGAPMTKFDRPKHNVVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YG22</accession>
    <name>A0A8B7YG22_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2 9">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110979269</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:phosphatidylinositol metabolic process"/>
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        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
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        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
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        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd13361">
        <property type="entry name" value="PH_PLC_beta"/>
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    <dbReference type="CDD" id="cd08591">
        <property type="entry name" value="PI-PLCc_beta"/>
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        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand"/>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
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        <property type="entry name" value="PI-PLC_fam"/>
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        <property type="entry name" value="PLC-beta_C"/>
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    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
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    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
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        <property type="entry name" value="PLCB1-4-like_EFh"/>
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    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
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    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
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    <dbReference type="PANTHER" id="PTHR10336:SF149">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE CLASSES I AND II"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
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        <property type="entry name" value="PIPLC_X_DOMAIN"/>
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        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
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    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
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        <location>
            <begin position="810"/>
            <end position="926"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGM5</accession>
    <name>A0A8B7YGM5_ACAPL</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110980226</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110980226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092389.1">
        <property type="nucleotide sequence ID" value="XM_022236697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGM5"/>
    <dbReference type="GeneID" id="110980226"/>
    <dbReference type="KEGG" id="aplc:110980226"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022092389.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19851" checksum="DA8BA5D29726630A" modified="2022-01-19" version="1">MTLLFNWPRRTPYLNQLDRAQRDSRLRLSCDGRCQAQRPTYAPTIMRSFTAPAAIVAPSALGLCTDRPVAGGLCPVCRSGIVNGNRTSGLLCCKINHSPACPACGVVFDDADDEREQPGSTANDDTNRQRHNQRVKGQRAKAPKEDHKKNKHQHDLLLKPQTVELTSTKKKFSGKKTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YGM6</accession>
    <name>A0A8B7YGM6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5 6">Kelch-like protein 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5 6 7" type="primary">LOC110980229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5 6" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022092393.1">
        <property type="nucleotide sequence ID" value="XM_022236701.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092394.1">
        <property type="nucleotide sequence ID" value="XM_022236702.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092395.1">
        <property type="nucleotide sequence ID" value="XM_022236703.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022092397.1">
        <property type="nucleotide sequence ID" value="XM_022236705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YGM6"/>
    <dbReference type="GeneID" id="110980229"/>
    <dbReference type="KEGG" id="aplc:110980229"/>
    <dbReference type="OMA" id="RVANNEC"/>
    <dbReference type="OrthoDB" id="2359033at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF23">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022092393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022092394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022092395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022092397.1"/>
        </source>
    </evidence>
    <sequence length="547" mass="63262" checksum="11AB0BAA806660F2" modified="2022-01-19" version="1">MNQANPQQEPPQQQVAMIRAMRRLRRQMLQAEAGNGEDDADPSDEDEPPIEEQVRELFRRGDTNDRRRNKNGYAEFLLWKKRRETGRQMVEHRMRKRRQELMPQFLINCVSPLFKNPRLSDVTLKVGPFVFHAHKLILCAWSEVFRSLLGERWAAGSPSDEPEVHTLNEHKVCEEYFEDFLRFLYTEEVDLDEDSVFAVLMLADKYLVRDLQHVCVEYLLYNLKTSTAPFLDAIKALKLTEDLSRVEQKSFSLLENHFHLWTTDDDKVPTLYWFEGSLLAKLLQSSNLVVPNETFIFDAVLRWLGTESCLVERQEFSDQLLSLVRFEHIPACDLATLLDDCSAALIPKLKEHIFEALKVRALAGEEAYQDTLKEFSSPRMYLEPMFCVRVANNECEVAGWRSFRELELCPEDNETEFEHRKLSCPVARQSENKNIYLVSKDMWAIGGMAFRKSPEDKWAVRFMLKPDFEDIGRSYRVAVVLLKSAPQGEHSFDAPVTCVDAGDIGKVIGIDVPPTALHCRADPTRLWIKVGIQVFGPDKSCGNWMYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YIB1</accession>
    <name>A0A8B7YIB1_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110980518</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="RefSeq" id="XP_022092963.1">
        <property type="nucleotide sequence ID" value="XM_022237271.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980518"/>
    <dbReference type="KEGG" id="aplc:110980518"/>
    <dbReference type="CTD" id="440275"/>
    <dbReference type="OMA" id="FEDIAWD"/>
    <dbReference type="OrthoDB" id="6778822at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000353">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="15">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="294"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="603"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="190"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="675"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="736"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="675"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="778"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="866"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="609"/>
            <end position="617"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022092963.1"/>
        </source>
    </evidence>
    <sequence length="1667" mass="187735" checksum="0EE99551BC2CEA78" modified="2022-01-19" version="1">MSDNIVESFQERQDNESEVLQAIFMDDFVDMNKGDHRNGMKMKLHLTPQQGMSGSGNAHVTVDMRVTCPPKYPEELPDIMFEKEKGLSIDKLKQLSKEINSMARKLKGEVMVLELAQHVQAFLHKHNVPGHKSFYEEMMSNKKKEQEEAAKEKEKQQLLQRKREEKERREIDEHIMRMQLAKEEFKRKKELANKENETSGQSVPSSPEKSQDTSGKSQGDSTPTRGKRQPDPMDSGSDSSKGRTRTLSESKITRNQSESETPNQKHAKARRQKSDSFHRGVVTTVFNTKTERTINRGQVISCGDKGSTIYVGMDTSTGELVTLREWVMKWKHGKGRKPLPDEEQAAENCVKQLGTVEQELLSLVKLEHPNLVHYLAIKHTQGKEAITVELLMEYAKGGSLNLQAFDGTPIPLDVLRRYTSDLLEAVVYLHGRGVVHKNLQASSVYVDSHGGVRLADYSLCKRLDDLNESILAGTHNVRFSDEKSYGGRGGKKGDILKLGILLMELIQAKQEVHYPCDIPQDLPADLQDLLQRCLDTDERNRSSAVSLLDHPFIKPSISPSLETNSNLPSDVNSSGNDRETEVSIPEPQSYDVHLGHSRLRSEFEVLDFLGKGGFGSVTKVLNKLDGNAYAIKRILLNPKSRELNRKITREVKLLSRLNHENVVRYFNSWIEVAESPPSTETDSDSLTTMTTTSPNQRLPPETRQPTKDKNSLSISDDIEKLAPKVSFSALGSLDWSSSHDTGRLDSSSDSSSDEDDVFGPSFMPYSDSSDGIEFEHTNAISDSSENFQSKQEEGKKRNAGNLPPQDAEPSRPLQYLYIQMEFCEKSTLRTAIDQGLYKDERRVWRYLRETVEGLAHIHSQGMIHRDLKPVNIFLDSNDLVKIGDFGLATAGNMGTAALPDIPQGDLHEAQILEASTGTGSHLTGKVGTALYVSPELCQAKSSHYNQKVDLYSLGIIFFEMCNPPLATGMERVQMLGKVRQKNVQFPDTFDEVKHENEAFVLRWLLNHDPEVRPTAQELLQSKHLPPPQMENARLQEMLRHTLSNSQSKAYRHIIQELFSQTVPAAADFTYDMDMHKGFSFRASVVQQTVYETLCRIFKKHSALKVNTPLLLPRNRGLEKSEMCVNLMGHSGGLVSLAYDLRIPFARFVARNNVTNLKRYCIERVYRERQIYGCHPRELTECAFDIVASSEAGLIPDAEILHVVSEIINEFPALQARNYSIRLNHTSLLTAVLNHCGIPEDKHHEVYKILSDARTEKLTKTQIQTRLCSMSLSEQQVKNLYDYIELEGHHCKVAGTLKSLVHCKGPNGSMAKQGLHELEAIISQAQVFGIRLEMIVTLSLVYNIHCFSGVIFQFVAESVHRKKKTAMDVLAAGGRYDHLIQLFKKPSSQPHQTCPSAVGISVSFEKIVSAVLQDTCMSETTPSVCDVLVCTIGSGSSYKDRIKVVRDLWASGLRADILYDSSMPLEEIQDYCRAVGISFLIVLKDRNETVKIRFFDKEKQVTECKVDFHLLVWTLHQMMNANKTETLEGAQQAAVKPAMLETTPTSNATNYNVTFVPRPEISARKRHERVVRIQSKIEPVLECITSKTKVEVVAVDLPLAVVKSMVAVLDFDGESNYASSVSTLREMHIKYKKALDEICYVLQKLKLENGVSFVILYTYKEDAFKVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YJM9</accession>
    <name>A0A8B7YJM9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LOC110979912</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="6"/>
    <dbReference type="RefSeq" id="XP_022091776.1">
        <property type="nucleotide sequence ID" value="XM_022236084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YJM9"/>
    <dbReference type="GeneID" id="110979912"/>
    <dbReference type="KEGG" id="aplc:110979912"/>
    <dbReference type="CTD" id="4255"/>
    <dbReference type="OMA" id="EPLAQCA"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000214">
        <property type="entry name" value="Methylated-DNA--protein-cysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.70:FF:000001">
        <property type="entry name" value="Methylated-DNA--protein-cysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.70">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46460">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46460:SF1">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="20">
        <location>
            <begin position="94"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022091776.1"/>
        </source>
    </evidence>
    <sequence length="179" mass="19468" checksum="C339193D6D718721" modified="2022-01-19" version="1">MAEMCLKSRVILRTPIGLVRVTACKTGVHDISLTAASEIPGEKVAVAVTEAPDHWLSPLKQCVDWLTLYFKDAKAAYQKPLPPFHRPNAKADSFTYKVWETLTNQVPCGETVSYGQLAAMAGNSKACRAVGGAMRANQIPILMPCHRVTRSDGALGNYMSGKGDSLKKWLLEHEGAIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKB0</accession>
    <name>A0A8B7YKB0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein LOC110980557</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110980557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022093057.1">
        <property type="nucleotide sequence ID" value="XM_022237365.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980557"/>
    <dbReference type="KEGG" id="aplc:110980557"/>
    <dbReference type="OMA" id="AAMEMTC"/>
    <dbReference type="OrthoDB" id="10072513at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21853">
        <property type="entry name" value="KNL1_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037388">
        <property type="entry name" value="Blinkin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040850">
        <property type="entry name" value="Knl1_RWD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013253">
        <property type="entry name" value="Spc7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16520">
        <property type="entry name" value="KINETOCHORE SCAFFOLD 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16520:SF3">
        <property type="entry name" value="KINETOCHORE SCAFFOLD 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18210">
        <property type="entry name" value="Knl1_RWD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15402">
        <property type="entry name" value="MELT_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08317">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00787">
        <property type="entry name" value="Spc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spc7 kinetochore protein" evidence="3">
        <location>
            <begin position="1503"/>
            <end position="1806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="814"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="896"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1371"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1666"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1265"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1291"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1372"/>
            <end position="1384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022093057.1"/>
        </source>
    </evidence>
    <sequence length="1983" mass="219171" checksum="ED590210FEAF851E" modified="2022-01-19" version="1">MSGIRIVPEGENLGVETRPRPKKRRSSILKSPSRNALQDLDSNADERDTTNVAKKKRRSSRRVSFANTYQVQEFLTTNQLHLLEETNVESTKPFSPEQDFEPPAHTKSSSSSSGKETTTTQSFQSDVSVGPGHCITGLETLLSGPIKNQSHQDVQESMMPYSYPQPREAAVQLPVIDETFELPLETQVGRSARGRSDPSNPETDEVPSWPGAASNHSSVAVGLVGPRYHCTLPMVDSFSSSCHSSDVSSASHLEVHNPDVDLFDAANFELKLCQEQFPAGYEDQESPANDEHVTGEAYVQKIDASSFLKSFMSSKTVEENFGQPVHSTSSTYADENQAAKQDNKDFPQQSFLDTVSSASHESGGPVKRKDAKSFLQSLLGNKSQPSEVLSDQTCFFTQDETASEMDLTACVSVETNGGTKKKDAGTFLKSFAESCPSDDFSPPGHSVVLSNVNKHPDEEQKTRFFDRDGETSSGMDLTTCVGSVLQVKDAFAVSVRHPDVTVRFGDDDKGSMELTQCIDGVQKQPEQPQASGQKRQSGRPLTDITQIFDGKIDGSEMDLTTCTNLQIPNSSNYRGPDGQTRIFYQNDTTAAMEMTTCLSVQEYPEKSQNHTYMYKEYFVGRQEMNTVGEKTRIFHQDDITGSMEMTACLDGKTDLPLLNKASTNLNSSVNLQGSVGAEKTQIFRSDDTTAAMEMTTCLDGNVNFSKSSGKSSIQKYNNQPCAEEDKTTVFCRDDTTVSMEMTTCIKGENSYSPNSWGGSQPQTAEQTRVFHRDDVTAAMEMTECLDERTSFTKLGTLTSHQEVNQQGSMLSFASECSKRKESTEPADGSSHKAKIKQVDEPNKKSVADELTGLDKTQMFKSEDMAGMEFTTCVDGLILESRSCPVGGKQIHTVDSIEKQPRSEQEISKGVSHPLSLDYPEDRTKTFPSDDAGRMEITTCIGGVLEDSSKTTDTQLVSTMHIDKTRIFTADETAQMELTTCVGSLKPLPSVVSTSSHRAQYIAAPDDTTKMEITTCVDGIFPKMSADSCQGETMKQLGDCTRIFSSDTASMDMTKCIGGLHLPAFAARPQPHGLDDQTRVFTSDNTARMEMTACIGGFLSKKSVEEATVPDSTDVDHPDHFHVMNTKLPPQMTDSVISSSSQQQHPLDQTRIFTSDNTASMEMTTCTGGIVEKDIPQSLGKINYPHATDQLPSHQTGFFDHEVTGKMELTTGIGGIKSRNAIQHSHEIPQVDSSQLSTGEEISQTQLTKCIDVLDGKTMGVTSLVQKSSQESTYEVAQSSEQTPGHGGSTRPEMKDARDSMEDNSLDGHVSMFQECLESSSSARRKELTKRSSDTFTIEPVSISIAATEPLTTCRRSDTYTLDKPSAACTLAENPTSDTTQSTDDVCNPAAATGDQVSPTEEDMPVIGDLNRWGSLDSSDGIENEQPVWLENTEDFVQLSAEAGVTRSMMVEAMKDQTDCESASAHELSSSADLGAQDVHVPPMLNTDIASRVQDILPASLLNLQTDVSLTKPTPGPVSMCKFLQFLTTSMSKGRRSVIPFLPQTASPKTLSDFMEDHFITKPKKDLYEWAVNHLSMSIEKMQGAVNEQEQRMSENNPDIVTEVECAPPEQAAHLQDHIESLYKACTKMSKASFQEWRQKMVNKTHQSLKKTEAEMNEILSSLSSSLDTLIKNMEELEKFKEGLDDTVTRLQRIEPPSQERVEEFINQRQQLAEKQEEVEEMKTSKVALQSESLRLKEEIKQYKEELADAREMEMLLSNKTTSNDALEEALMKLEDIHCLQQWRWRKDTEEELVFTFLEDSFIFTVKLGKEIEKGSGVQEKEITSLHMESLLADDAEVSAHLAHHLIQASIDVDFLHSRHPTTASLKMLLQDLSEVVSQADSIAEEIDHIRYRHVVTVNGTNATIEFSNLDAMVRFLVTFKFFPGGYPFSSMSANFKHKIGILKEQDVQTVINEVKPGWTYLSRLVKRINLLIQQCISSEESTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YKC6</accession>
    <name>A0A8B7YKC6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110980566</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110980566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022093072.1">
        <property type="nucleotide sequence ID" value="XM_022237380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YKC6"/>
    <dbReference type="GeneID" id="110980566"/>
    <dbReference type="KEGG" id="aplc:110980566"/>
    <dbReference type="OMA" id="ARIWKRI"/>
    <dbReference type="OrthoDB" id="6600747at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004210">
        <property type="entry name" value="BESS_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006578">
        <property type="entry name" value="MADF-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039353">
        <property type="entry name" value="TF_Adf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243:SF67">
        <property type="entry name" value="COREPRESSOR OF PANGOLIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12243">
        <property type="entry name" value="MADF DOMAIN TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10545">
        <property type="entry name" value="MADF_DNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00595">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51031">
        <property type="entry name" value="BESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51029">
        <property type="entry name" value="MADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MADF" evidence="3">
        <location>
            <begin position="49"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="BESS" evidence="4">
        <location>
            <begin position="241"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="202"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022093072.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="33193" checksum="560AEC9A6D803937" modified="2022-01-19" version="1">MVALSTFSPLILVFLEKKNNTVPTGLGVWMSTCAEKMPKNMLPTTICEILIALVKDNPTLYDVRDKDHKNAAQIARIWKRIADQINYQERDGDYWKKRWRMLRDTYVRKRRTIKTKKSRRDASRAAMWRFYEMMDFLASHTDQNVAGGTISGQNDTVVTLEVEEINDEDALDLASIGEGSDRIDLVEKSSCTIPFLVNAPLSHSKRPSRKRNKDRQDLVGAFPDPCGANTGGLRASSPPAKDEDEMFFEIYARRLKQLPPHLKSVVQFQIAQLFFNAENPHLPQQAIMPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YM18</accession>
    <name>A0A8B7YM18_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="24">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LOC110980806</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 24">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="24"/>
    <dbReference type="RefSeq" id="XP_022093490.1">
        <property type="nucleotide sequence ID" value="XM_022237798.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110980806"/>
    <dbReference type="KEGG" id="aplc:110980806"/>
    <dbReference type="OMA" id="KPCMGIV"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="13 24" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0677">Repeat</keyword>
    <keyword evidence="22 24" id="KW-0804">Transcription</keyword>
    <keyword evidence="12 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="26">
        <location>
            <begin position="245"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1540"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="1567"/>
            <end position="1586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1587"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="1608"/>
            <end position="1918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="RefSeq" id="XP_022093490.1"/>
        </source>
    </evidence>
    <sequence length="1924" mass="213079" checksum="6DFB5CE6CF8C7AC5" modified="2022-01-19" version="1">MALQFHDSKAPMRDVRRVQFGVLSPQEVRRMSVVEGGIKYAEVMEGGKPKLGGLMDPRQGCVDRISRCQTCACNQVDCPGHFAHIELAKPVFHPGFLTKTVKVLRCVCFFCSKLLVDQNHPKVKEILNKSKGFPRKRLAHIYDVCRGKKICEGGEEMDQTFNADLAKREGEVPEPRAQGHGGCGRYQPQIRRNGLDLTAEWKHVNEDTQERKIALTAERVHEIFKRISDEESAILGMEPKFTRPDWMIITVMPVPPLCVRPAVVMFGTARNQDDLTHKLADIIKANNQLQKNEQNGAAAHIIAEDTRMLQFHVATLSDNELPGLPRAMQKSGRPLKSVKQRLKSKEGRIRGNLMGKRVDFSARAVITPDPNLSIDQVGVPRTVAQNLTYPEIVTPFNIDKLQELVRVGHNQYPGAKYIVRDNGERVDLRYHPKTSDLHLQCGYKVERHLRDDDVVIFNRQPTLHKMSMMGHRVKILHWSTFRLNLSVTTPYNADFDGDEMNLHVPQSMETRAEVTEIMMVPRQMVTPQSNRPVMGIVQDSLTAVRKFTKRDVFLQKEELMNLLMWLPNWDGHIPQPAIIKPRPLWTGKQMMSLIIPPNVNLIKAHSTHPDEEDRGPYKWISPGDTKVLITNGELISGIVCKKTIGASGGSLGHVIFMERGPDETRDFYGNIQTVVNNWLLLEGHSIGIGDCIADAQTYEDIQNTIRKAKQEVIEVIEKAHNDELEPTPGNTLRQTFENQVNRILNNARDKTGGSAQKSLSEFNNFKCMVVAGSKGSKINISQVIACVGQQNVEGKRIPFGFRHRTLPHFIKDDYGPESRGFVENSYLAGLTPSEMFFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVRYDGTLRNSNDHLVQLRYGEDGLDGTKVEFQNLPTLKPSHRAFEKRFRFDCTNERALRRSLTENIVKDVVANAQVHLEIEKEYEQLREDREIMRKILPMGESKVVLPCNLERMIWNAQKIFHINPRHSTDLHPLMIVKGVRDLSKKLIVVKGEDRISKQAQENATLLFNMMLRSTLCSRRVIEEYHLTNESFDWLLGEIETRFNQALVHPGEMAGPLAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKEIINISKRPKTPSLTVFLVGQAARDAERAKDILCRLEHTTLRKVTANTAIYYDPEPQNTVIEEDQDWVNLYYEMPDFDPARISPWLLRIELDRKRMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMSSEESKFGEEEEQVDKMEDNVFLRCIESNILTDMTLQGIEQISKVYMHLPQQDNKKRIIITEEGEFKPIQEWLLETDGTSMMKVLSDKEVDPVRTFSNDICEIFQVLGIEAVRKSVEREMNHVISFDGSYVNYRHLALLCDVMTAKGHLMAITRHGINRQDVGALMRCSFEETVDILMDAAAHAEVDHLKGVSENIMLGKLAGVGTGSFSLLLDAEKCKHGMEIPMGMGGGLGGMTGMFFGAAASPSASMSPQMTPWNQGATPAYGASWSPMGSGMTPGAAGFSPSAQSDASGFSPGYSPAWSPQPSSPGSPGPTSPYIPSPASPMSPSYSPASPSYITGSPATPQSPGYSPTSPSYSPSSPGYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPSSPKYSPTSPSYSPTSPSFSAKSPSYSPTSPSYSPTSPSYSPTSPAGYSPQSPSYSPGSPSYSPSSPKYSPSSPSYSPTSPSYSGSHFTPTSPEYSPTSPTYSPASPSYSPSSPKYSPSSPKYSPASPTYSPQTPKYSPTSPSYSPTSPKYSPSSPSYSPTSPQDSYSPMSPGYSPASPSYSPSSPDIEADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YMI7</accession>
    <name>A0A8B7YMI7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CKLF-like MARVEL transmembrane domain-containing protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110981302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022094473.1">
        <property type="nucleotide sequence ID" value="XM_022238781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YMI7"/>
    <dbReference type="GeneID" id="110981302"/>
    <dbReference type="KEGG" id="aplc:110981302"/>
    <dbReference type="OMA" id="RINIYLF"/>
    <dbReference type="OrthoDB" id="6258237at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050578">
        <property type="entry name" value="MARVEL-CKLF_proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776:SF49">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22776">
        <property type="entry name" value="MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="26"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022094473.1"/>
        </source>
    </evidence>
    <sequence length="166" mass="18365" checksum="B9F5BE4AC728A4DE" modified="2022-01-19" version="1">MENKEQGGAGAGDGQTERKCGMDMSYVKSINGVLKAKMMGWSLIAFILCIAAGPSITSIFFGVVIFCGLFLSVGLFIVFAFSKDRNITRINIYLFDFLVSVIGTIAYFIVCMASVFNILEPPMIAAAIFGFIAMVSFGASIWFNFKRWREFKPRASGTNETYDTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YPW8</accession>
    <name>A0A8B7YPW8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="10 11 12">Octopamine receptor 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11 12" type="primary">LOC110981761</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11 12" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022095322.1">
        <property type="nucleotide sequence ID" value="XM_022239630.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095323.1">
        <property type="nucleotide sequence ID" value="XM_022239631.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022095325.1">
        <property type="nucleotide sequence ID" value="XM_022239633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YPW8"/>
    <dbReference type="GeneID" id="110981761"/>
    <dbReference type="KEGG" id="aplc:110981761"/>
    <dbReference type="OMA" id="LFCPVMQ"/>
    <dbReference type="OrthoDB" id="5960344at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00637">
        <property type="entry name" value="7tm_classA_rhodopsin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698:SF1">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 13C-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45698">
        <property type="entry name" value="TRACE AMINE-ASSOCIATED RECEPTOR 19N-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="371"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022095322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022095323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022095325.1"/>
        </source>
    </evidence>
    <sequence length="413" mass="47064" checksum="2F79E4E3CD01A642" modified="2022-01-19" version="1">MENTTAAMEDTLYTSTKSSITEGPSEDELSPSAKFGVAVYCIIGSFGLVGNLVACIVFNTIKSKKNQVSLLIFTQALADLVSSIVIIIFGITRVYRHRLPTTGGTGEWLCRFWWTRFVIFYFFAISTFNLTLISLERYIAVIHPLTYAKRFTRRNTKIFVVIVWLFCPVMQWGQPLWGYTVVNGTCVTIKSWDDFGQAFFGVLLFLWELITPICVMGVCFVSIVITLRKKELACRTPTVKVKPERSGSVFKPIKKHVRRDITMTLLILFILFVICWTPNQTTFVQFNLGGPLDFNGGWYHFTVILGFANCCVNPFVYAFRLRQFRVRVLLMLQCRCKAFDRADESDNELFRDPASTSNKWSSRREKLGKIFKLTRQDNASLSRTPENTASPEGSPFPSKKSTLKKTDSTNELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTN2</accession>
    <name>A0A8B7YTN2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vesicle transport protein USE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">USE1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="primary">LOC110982513</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096653.1">
        <property type="nucleotide sequence ID" value="XM_022240961.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022096664.1">
        <property type="nucleotide sequence ID" value="XM_022240972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTN2"/>
    <dbReference type="GeneID" id="110982513"/>
    <dbReference type="KEGG" id="aplc:110982513"/>
    <dbReference type="CTD" id="55850"/>
    <dbReference type="OMA" id="KYYTNAQ"/>
    <dbReference type="OrthoDB" id="4506189at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022096653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022096664.1"/>
        </source>
    </evidence>
    <sequence length="262" mass="29978" checksum="5BF7E855E54E3A2B" modified="2022-01-19" version="1">MAMASRLEINLQRLLTRCEAMAGEQDHGDWRLEKFVGALQEKLAELKRSPSLPSQEALAEYAKKIDFLKGLIQTEKLTSASDKAMASQLLAPAHSSTSISSEPKTHSKVLPTSSKDLHLQATSRYANEMRRELLETDDLQENGLRHRRLHDPDDKASSDDLDAVLQHHHNMQEKLAEEMLSLTRSLKHNTVAASNIIQEDNRRLGETIQLADSNYGRLKVESERLQQHTQRACNWWLWGSLLCVSIVFLWMIIFIRFFPKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YTW4</accession>
    <name>A0A8B7YTW4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein LOC110981491</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110981491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022094786.1">
        <property type="nucleotide sequence ID" value="XM_022239094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YTW4"/>
    <dbReference type="GeneID" id="110981491"/>
    <dbReference type="KEGG" id="aplc:110981491"/>
    <dbReference type="OMA" id="WMKEATF"/>
    <dbReference type="OrthoDB" id="6354602at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00099">
        <property type="entry name" value="IgV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45889:SF8">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034999759" evidence="3">
        <location>
            <begin position="21"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="28"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022094786.1"/>
        </source>
    </evidence>
    <sequence length="606" mass="65117" checksum="34B39B8E83BB40DA" modified="2022-01-19" version="1">MATLIFIIVLFAVSTVCLLAQDTPGSLPFFVMEPRDTTVQIGSTARLECQVSSLADNQAVAWMKEATFQTSGRSLLTADPDKPSRITVEGSKSDPNVHFNLFIHNVRPEDAGVYHCYVVEFWELNERRWSRSRPATLTVVDVLRPSVRCVQPTVRQLADATTQSQTAPIGCTVLNNKPGMTIKLQGFHGTVLFENKTDSTEPYNLRHRMDVAALRTGRVTCLIEFRDETSQSGEASRSCSMGPFIEIPPARNRTRITVHLVPGGDAHLTCPLNKGHRLHGALLAKPSWSLDPPLPVSRYSLSPDGIRIVLTRVTTQDEGLVVSCKVPSPGGGYRVVDMEVRVRSPEAGGSRPDVRGHQVHESGGSLDRVAPKPVIGQAAWSVLRGRVSSGRLKPAPPSMWPGPSPDTVYHAPSVGIPSKATLSPTVSVSKNTKQDADNGTSTHSPATNSSSGGTVTPVTDPAPLTLSPLIIVVLCEAGMSLVILVIAFAVLCQCCCRNQTKAKVRGDKDLTLAGASFGKQSTTPTLLTYKSTSGSPNPNLSHKKLPPTPPDPIYARPESLASGKTVLRESDLPPTGSWVFSSVNSENGEAETNARDSGNEIYVTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUI2</accession>
    <name>A0A8B7YUI2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Proteasome 26S subunit ATPase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110982675</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022096959.1">
        <property type="nucleotide sequence ID" value="XM_022241267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUI2"/>
    <dbReference type="GeneID" id="110982675"/>
    <dbReference type="KEGG" id="aplc:110982675"/>
    <dbReference type="CTD" id="5701"/>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000075">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="209"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022096959.1"/>
        </source>
    </evidence>
    <sequence length="434" mass="48611" checksum="0502AEA0A277D389" modified="2022-01-19" version="1">MPDHLGNDMRKVKNEEEKEDKPIQALDEGDIALLKTYGAGPYTSLIKTVEEDIQNAMKKVNELTGIKESDTGLANPALWDLQADKQTLQSEQPLQVARCTKIINADSEDAKYIINVKQFAKFVVDLHDNVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDIGGCKEQIEKLREVVETPLLHPEKFVNLGIEPPKGVLLYGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALVRPGRLDRKVEFGLPDLEGRTHIFKIHARSMSVERDIRYELLARLCPNCTGAEIRSVCTEAGMFAIRARRKVASEKDFREAINKVIKAYAKFSSTPRYMTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YUZ0</accession>
    <name>A0A8B7YUZ0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc finger protein 142-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110982431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022096507.1">
        <property type="nucleotide sequence ID" value="XM_022240815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YUZ0"/>
    <dbReference type="GeneID" id="110982431"/>
    <dbReference type="KEGG" id="aplc:110982431"/>
    <dbReference type="OMA" id="CTTFFCR"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000671">
        <property type="entry name" value="Zinc finger protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF64">
        <property type="entry name" value="LINKING IMMUNITY AND METABOLISM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="522"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="637"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="40"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022096507.1"/>
        </source>
    </evidence>
    <sequence length="912" mass="102909" checksum="E2C852BBFE0AA4A7" modified="2022-01-19" version="1">MDPTLLDEMDFSFSCDRCSFSTKDMLQIKLHMVEHRYQGKEPGKTVAAAGSDTPSDQANQSLSQDAGAKNHSEDASTLSNKDTPNATPFVSDTPSVTPALHSTQQSRTGDDTHPSPGLRDNVSSQVSREKDGSSKNVEEREEKTHRSDQNASREATVIVSRIEQSLKEISTAQPQPPQDGAPGPAKSTGLDSIADRIHSRRRPASKKPQEEPEEEDEEYVPYRPVKRSASRLKRHARRVNRRVAVAAAPGPRARAKLRPAIPSDRYKCQHCHFVCKFKQNLRAHMRGSHPEDYTKVIQEKKAEHGGQEGGREPESRVPEDAHEPGGVADEIQSNVAPDRYQCTLCTTFFCRFKKDLHDHKSRVHGIPAPVYKYQSRIPENRYQCPQCDYVCKFQRTLRLHCRSAHPKAAKSPEAKERKEKKEKRALDDRYRCSECDFACKFKGQLKNHRSAAHKKERPPKTVREQQCEFCQKFIQGTMHHYRRHLKTHTGDKPYKCTICDAVFGDQSRLNAHAPIHQEERNYLCDQCGKSFKRAINLRMHRKVHLVVRPHGCELCSYRCKRHDTLNLHMKRKHLKIRRILCDTCGKKFFSEKECQLHAARKHLPRPTPFRCTFCPAAFPFAYNLRAHMKKHPEHKPFRCEYCSFESRSKASLQDHEKMHTGEKQKKCEMCDYTTSTSSNLYKHRKRQHGVVLNRTKSPRVHSPSQDRQPVLPLPAAATLQGSPHVSMAPTPLSTTPQPHPMLPTPEGLHVHHMHIQRHLQGALSPLPSQIQGSPSPALTPSVTQSVTVPATSSGHMDLRSVQPYEEIEFKDRRAVIYSREKSLIGSVITEALAEARNVVQNELYNSGHVIQSTVAPPPGQHQTGLPVTTTMAPPHANIVPAESIIHGTIPTSAGIPPSGASGIFNSIMNIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YWE4</accession>
    <name>A0A8B7YWE4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfatase-modifying factor 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110982701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase-modifying factor family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097012.1">
        <property type="nucleotide sequence ID" value="XM_022241320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7YWE4"/>
    <dbReference type="GeneID" id="110982701"/>
    <dbReference type="KEGG" id="aplc:110982701"/>
    <dbReference type="OMA" id="WQGQFPW"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051043">
        <property type="entry name" value="Sulfatase_Mod_Factor_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150:SF33">
        <property type="entry name" value="INACTIVE C-ALPHA-FORMYLGLYCINE-GENERATING ENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23150">
        <property type="entry name" value="SULFATASE MODIFYING FACTOR 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034900143" evidence="3">
        <location>
            <begin position="24"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="38"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
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            <dbReference type="Pfam" id="PF03781"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022097012.1"/>
        </source>
    </evidence>
    <sequence length="371" mass="42033" checksum="4AEA673B324F096B" modified="2022-01-19" version="1">MHIRAKFLLYSFSVLCMIWGSEATLKEDVPADAEVDQYEEMVFIEGQQFTMGTDAKDAKDGEAPSRLEMVKSFKISKYPVTIASFRKFVRAKKYKTEAEQFGWSFVLEMFVPEKVSKAAKDRIKGAPWWVPVDRAYWRMPEGTDSTIEGRLNHPVVHVSLRDARAYCDWHGWRVPTETEWEFAARGGLAKRKYPWGNKFDVTRMNFWQGKFPDTNVAKDGYKGVSPVDAFPEQNDYGLYDMVGNVWEWTSSRYDSQDDAPESDGTKYALRGGSYIDSKDGSFNHQVRVTTRTGNTPDAGSDNVGFRCAMSVTSTDAQRPPKGKKINQGRSQQAEEPRVVVQDGKKAKPIKPNPADLNGKKTTGEKKNKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YXL6</accession>
    <name>A0A8B7YXL6_ACAPL</name>
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        <submittedName>
            <fullName evidence="10 11 12">Myocyte-specific enhancer factor 2C-like isoform X1</fullName>
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        <name evidence="10 11 12 13 14 15" type="primary">LOC110982935</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Eleutherozoa</taxon>
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            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
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            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="XM_022241735.1"/>
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    </evidence>
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    </evidence>
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            <dbReference type="RefSeq" id="XP_022097432.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022097433.1"/>
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    </evidence>
    <sequence length="520" mass="57200" checksum="0087D92814D0A735" modified="2022-01-19" version="1">MGRKKIQISRINDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSSNKLFQYASTDMDKVLLKYTEYNEPHESKTNQEIIELLNKKESKGCESPDQDVDAYNCTLTPRTEAKYSKINEEFDRMMNGNMARGQAMSNSYPTSMPVAIPITDQQQQQQHQHQQLTTPHLYNNSPPSQPAMVSSPQLMQPPATAPRQSLSPQPPMSRMSLSPQPPQQQQQQQQQQQQHHHSPHMRTSLSPQPSMMRNTISPQPPRPASTGCLVSVSEDPDKTNDRDKPTNSDQREAGNTYLGPPHSSSGMSPVSPNAGTNNNLPLKSMNKQQFPHRPGLKVVIPTTRPGLQNNVGTSLNQSLATPTVSLTTPSNPQGVIPNYPSALPTGYHPGSEFQLTSADLNQINFNSPSSLSLASWQSQSTQAGPLTAAIQAAGIAGHPLSVSTSSMPGQNSFTTSTAIKCEPLSPPRDRKLNPQMMPHQPSTSPGPSNNDPNGSPPYNDHGGRALVDKDLPPSKRPRISEAWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7YZ83</accession>
    <name>A0A8B7YZ83_ACAPL</name>
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        <submittedName>
            <fullName evidence="9">BRCA2-interacting transcriptional repressor EMSY-like isoform X1</fullName>
        </submittedName>
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        <name evidence="9" type="primary">LOC110983604</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <end position="1324"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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            <dbReference type="ARBA" id="ARBA00023117"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50014"/>
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            <dbReference type="PROSITE" id="PS51138"/>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022098663.1"/>
        </source>
    </evidence>
    <sequence length="1333" mass="141849" checksum="5720BA212DD082B0" modified="2022-01-19" version="1">MWPKLLDMSKDECKRLLRRIELEAYAGIISAFRAQGDLTKDKKQILDELATTLSISTERHRAEVRRAVNDEKLSTVAERLSGPNNSSEWAIEGRRLIPLMPRLVPQTVFSLTANQAANAAFSHNLTLPLPSQTAKKEASSENSVKLPSPSSNVVVLPSGLSIPIKGGPDVDVESIPAKKSRRDSSHLQSKEPISSSVAPVLQTSLSPSLSVPSMSFTKSTTGNTITSNRSSSLSSSKHQVGYSAAISKQQSHRSLGGQSSSVGLTSSPTNKSGVGPAQSPLKFTYTKTASMSGNTVPTSSAQKVILVSSSSTSYTPSILQRSQSVPSAKPSFTKAGTKQSVILTSVSGQSFRQSESVSVGKHPGIAAGARQHTGISNTPLINRQKIAVSGRQGEASGSRISTSDMMPGTTAGGAGARKQSGNVGSVSAVNSSIITARTTASVISSQMTYVAPSMAGKPRGRAVSKQKLQKQVNMTPTCGITTPTEEVTSSKKQPGKSDIGMKILTQSVTAGTKLPRSSNQSSPLVEMSHKVSLATGTISTGKPVTSVAGHKVIISSTSAGVVPHHVAVTTPLIRTKPSTVSSMSSVNAKVVQGGTVNIGSGSKVVVTSAVVNQKVIQTIKATTTANVSQTVTSIVGSKSSMLLHKSYTQGSQVVISDPSKSPQAHVTSSLLQRPKISMVSAAPTSTTAPSFLSAGICFPSPQNTSSIAMTSVKSSGSRGMRSPITMVTPGSLLSQKRSVGSVSPNTLQSSGNTRVVEDVQSGRQGRDYSGSFTRGLLGSYPHPNNEWIDYDGSPPDSSASSAIKALLEFRSHPDAQKHSQTIDLSHIGSKSASKTTSLLTMPSTQLTTAPSRLTHRALLTTRVPQPATDMPTLGSPAGDVSQSSPTLLTNIQSRLKKALMSDRPEKPASAASFLQSATAEVEKAFQEQSKIHPAKQDVSLKETVLSCSQDERASSPSRQSNSHIHMKGQSQKGKKESQEVTIEDQGVVTDRVNVSSEEVSSFVDQFEQFLESEGIEEVSEIQEKSQSDHVAMQKSSVSKKTGQSTDSFKSLSEVLSSTPAGLSDCVSSGSVATDFALPSWRKKTDFETLTCGQKGAASVVMESTSVDISQMKLEDFTSQRLQDSEDVDDEKQSNTSLESSPVKITGSCVNVCVSAGTGLGSEETQGVRISNRKRKAPAPIDEEPGPTSMSSWARAAFNLLQRVMRFRGANRSKGDLNAASWFTRPVAASEAPGYNRVIKYPMDFGTVKRKLENGRYDNFADFHNDMMLVHNNCVQYNPPGHEIRRDCEEVFQFYTAEYKKLIERWEKLSPKKPKVEDQRSDKGKSIASRSIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z0V0</accession>
    <name>A0A8B7Z0V0_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Digestive cysteine proteinase 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110982715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022097041.1">
        <property type="nucleotide sequence ID" value="XM_022241349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z0V0"/>
    <dbReference type="GeneID" id="110982715"/>
    <dbReference type="KEGG" id="aplc:110982715"/>
    <dbReference type="OMA" id="YEIDYTS"/>
    <dbReference type="OrthoDB" id="65740at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000087">
        <property type="entry name" value="Counting factor associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034682378" evidence="7">
        <location>
            <begin position="22"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="244"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="328"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022097041.1"/>
        </source>
    </evidence>
    <sequence length="550" mass="61476" checksum="5C1EA09D207BEE77" modified="2022-01-19" version="1">MLYQILFVFLAAAVLFDSNDAAAPKPPTFGSRYHAKGFVQLPYAELNEPFEIYFDGQKSMGRIDFYGGMDQAFYDGAKKPYGVAYEVYPTVKSKTSTTPETTCLTMTGKKGSLIMPQSMLPNLNGFKPNGQKLINGQMTDVWMMITNPKTAKVNTYMLYVSRGAKVRPVRYEMMGYDTLLGSHYDKYVIDYSMFDDTTAFQASVFTPPKVCNVTLPSGIENHIRVNPYQELFNPELGDRYQHMFKEYKVKHGKVYADEEHEKRKVQFMHNVRLIHGNNRQGLGFSLAVNHLADLFDDELRMMRGRRPSNRDDIGGAPFSTEDFKIKTPPPSLDWRLNGSVSQVKDQAICGSCWSFGAAEVIEGAYFKKNGKMVRFSQQNLMDCSWGFGNMGCNGGEEFQAYEWVLANKGLMTEEAYGPYLGQDGKCHFDASKAGVKLSNYTKVQSGNKTALTLALANVGPIAVGIDAHLKTFSFYASGVYYDKACGNKPGDLDHAVLAVGYGTMIVDKKSTPYWIIKNSWSTYWGNNGYVLMSQQDNNCGVATAATYVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z103</accession>
    <name>A0A8B7Z103_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 92 protein</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">LOC110983478</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="RefSeq" id="XP_022098454.1">
        <property type="nucleotide sequence ID" value="XM_022242762.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022098455.1">
        <property type="nucleotide sequence ID" value="XM_022242763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z103"/>
    <dbReference type="GeneID" id="110983478"/>
    <dbReference type="KEGG" id="aplc:110983478"/>
    <dbReference type="OMA" id="FTHKLER"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF87">
        <property type="entry name" value="GH12965P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022098454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022098455.1"/>
        </source>
    </evidence>
    <sequence length="490" mass="58020" checksum="86935CB6174A25EB" modified="2022-01-19" version="1">MTFSHQIKHTEILNSVTMRRLRYYVMTQPWWGWIAFFAVIILWLLSSTILQPSFTAKKQREHRAKRLAAAFAEWRKYTTMLDIKRNASAYSRSLPADESCFFTHKLERSDMPTIHSAFVAQESSSVVLVGVRFLREKWNEARFTCEFPNGEMTSIDPVVDDYRSFGYLSQYVFVMTCLLPKAYRGKRNFTMSLYKETWRRKWYRYAYTNFTVCRGVGTHSGAKKQFLSVCTMVKDMDDFLPDWLDFHRFVGVEHAYIYDNAPEDLSLLRETVREHVESGFVTVIPWSHRPSHEKSYLEVQIAHENDCLWRHRYDTHWMIKIDVDEYIQPMNPSMPKITDYLRDPHLDQFGAVRLQNWFFGRRNLTETVPGSIIERNRWRPEDPTLPNTGRDKNILRPINVHYFKIHAIKLGGEAKSIDPRTELRLVHYRGDNPRIRHFDLPDFSVLDESMVQIWRKVKQSKQRGLMKDFDSSSVESKDNEIIKLLGKNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1L2</accession>
    <name>A0A8B7Z1L2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984015 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099489.1">
        <property type="nucleotide sequence ID" value="XM_022243797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1L2"/>
    <dbReference type="GeneID" id="110984015"/>
    <dbReference type="KEGG" id="aplc:110984015"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034356234" evidence="1">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022099489.1"/>
        </source>
    </evidence>
    <sequence length="120" mass="13568" checksum="E231E642D5B2855A" modified="2022-01-19" version="1">MKRHPLLCVAIVCSTVIEAPNVSCPEDIYHPYIRTLEQPHHWYLGRHCHQLSTAFDASGIIYYDDAGNVVVSNGTYEIGTTTITCNGTDYALNAGSCLFNLSYWRRRNNQSDCNYFNNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z1N9</accession>
    <name>A0A8B7Z1N9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sarcalumenin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110983716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Sarcoplasmic reticulum membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022098887.1">
        <property type="nucleotide sequence ID" value="XM_022243195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z1N9"/>
    <dbReference type="GeneID" id="110983716"/>
    <dbReference type="KEGG" id="aplc:110983716"/>
    <dbReference type="OMA" id="PIMSHER"/>
    <dbReference type="OrthoDB" id="422720at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033018">
        <property type="term" value="C:sarcoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033017">
        <property type="term" value="C:sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09913">
        <property type="entry name" value="EHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000635">
        <property type="entry name" value="Sarcalumenin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031692">
        <property type="entry name" value="EHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051943">
        <property type="entry name" value="TRAFAC_Dynamin-like_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681:SF1">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43681">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16880">
        <property type="entry name" value="EHD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="9">
        <location>
            <begin position="158"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022098887.1"/>
        </source>
    </evidence>
    <sequence length="542" mass="61527" checksum="74D39F32B51CDF61" modified="2022-01-19" version="1">MAAHSMGRCFCFARTNERRGKHKSPNHGFICQPTSRPIIWVATLALLISSVSCKDAPQQKTPPSEASSSQEHTKPSPPSDKTATDKHGMTLPIDTISRSRDHIFDLLNLDRQGLLLDAKFVQDSIEKMKNIYHLSIEPMAEAYKFETMGHPALSDGELDAKPMVLFLGPWSAGKSTMINYLVGLEDEQRLPTGAEPTTADFTVVMHGSQYRSVEGLVLATDGKRSFGSLERFGNGFLERFYGMEYPHKMLEKVTLVDTPGIIENRKQQERGYPFNEVCEWFMDRADLIFVVFDPTKLDVGTELESTFKRLKGRESQIRIIMNKADTIAPNELMRVYGALFWNLAPLINVTEPPRVYVGSFWQKPFQLQTYKDLFLSEEKSLLIDLNNMIENQLHNKIATVRRRAKEIRTHAVTVNEYLKKFNRNKPIALMGNPEDTMRDIVQNPDKYNIFKTVLAHANISKYDLPDPEEFKTFFAINPIDSFQPLETQCSYFSGCLLDRIEQAISIDLPKLLESIQKESGLSGECSTQGGCIQSEKNMYSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z2U4</accession>
    <name>A0A8B7Z2U4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110983078 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110983078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097691.1">
        <property type="nucleotide sequence ID" value="XM_022241999.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022097692.1">
        <property type="nucleotide sequence ID" value="XM_022242000.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110983078"/>
    <dbReference type="KEGG" id="aplc:110983078"/>
    <dbReference type="OMA" id="RVRCEME"/>
    <dbReference type="OrthoDB" id="10413204at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
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            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
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            <end position="245"/>
        </location>
    </feature>
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            <begin position="261"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="450"/>
            <end position="481"/>
        </location>
    </feature>
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        <location>
            <begin position="595"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="856"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="958"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1292"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
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        </location>
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            <end position="242"/>
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            <begin position="919"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022097692.1"/>
        </source>
    </evidence>
    <sequence length="1397" mass="154562" checksum="F4BE98059A3ADDE0" modified="2022-01-19" version="1">MDSGNGRKPDAQQETTKGVNGRKRPNASVGAKSSTSSSGTDVDTAILLARAVHLRGSLTTADRPRPATGIERGSNVGSHSHHFVGSRKQAAYADSGYVRPHHSRADVNISQQAINTEIDDEHMPKGDLSTVESSKSDTELLSTQEAEVVQDDSVTRLSGLLVNAVTLASAGEMLHQSKSSNPTFVSHLNKCNSSSKTYESGLADLDVSPEAKGHRSNGDITTHRSAYSIEDERGAGLTEGKRSSHSMLGRIKVLTSCLSSSDEGWSREDMTASSEDSSAKRRLSSKITKKKMKKKKKENGGEDVEKRNAEEKSSSESEVGIKIIEATALEMVDEAAVEKEVEKKPKDAVVEATDHMEISRGPEISEKELPELTPPDVLKEIKQKGDKEAPSSPQSDRVNEQAQCHEKMVVAPQHSGSSIELLHDDNKDVEGGEQVLSAIVTPGKTSLTIAKPAISGETKTPSKRSLQRGSDTNQVHVTHHGSAPVQVLKQADEEDMKSQPEIALKAVKERYRVLSEQISDAIPGVSIDEKVRLAVLGSLSYAAKSGDRPETGRRVASAPGPLENMAQHLAEEFAQEQAESGIASFEGTYCDESSNHYHGSIKGKKDSRSSSDSAKDLSTSAQDRSADVTTSSDSSQDDYIQKMRAAQRLINSHHKTTPTPQQLPSMVVNVDGNTKAAGDLLDSVYDPGLMLIRNDDDRDIKKGNLGDISPSTVSSGYGSAFQAKLADLEANLNMSVGLGKPYKVDVPIEEDSMRKKELGYILKMLEKEGGGQGPDSHRDPALLESAVNYLYWSRHDAQDLLRKPQQHQKVVIEDQLEAQNLQLDLPPYSAVKGSETLERLKAELEHKLKHVEDAISQNQESEAAQVAADLAKTEPRPKTLEDIRSSLTAQEQVRKDGTVQPPISKPVNLALPNTDTQYSSSSSSTEDSRPPSSFHYNRSVALMSPGGALGSSVLLEECESARRVRREMEERIAELERGKEEMAAQMKERRLTSVQLEAHLFSQLTTLTQEYQNLMAHDQEHKQLSKELKLQLDRKQKELEEALTHTTQEGTDSQQLQDKLDAVTFESKEKIHQLIVQLTLAQQEKARLQKSLQQEAVRQEAVRENAKKRAEEARREKDTLIEELNQERNNRTQLDAELLSHARDLHQLAASLQDLQVENRSQAGEVRRLHGALEQSIQDRAELQQELKEAQQRLEAKEEQWKRQKQQLIDHLSETKACLEKHQLHLKTLSHANGTLSGSAAQLRDSYQALSCQLHEERLAKERASQEAERVREELEAERKKREELVSSQLSQWHRNLQTSTKNLSAALQNKIHRQQQELQWLRVTNTELTADLPSNIRLSEGVGGQCDLLHEVSTSGACHDQHQSHHQHRVGSNSGGSIWTEPCQCCHDCHRHHRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z321</accession>
    <name>A0A8B7Z321_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110983113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110983113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022097771.1">
        <property type="nucleotide sequence ID" value="XM_022242079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z321"/>
    <dbReference type="GeneID" id="110983113"/>
    <dbReference type="KEGG" id="aplc:110983113"/>
    <dbReference type="OMA" id="MAFAVCS"/>
    <dbReference type="OrthoDB" id="10003283at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF84">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034717894" evidence="2">
        <location>
            <begin position="24"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="275"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_022097771.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="57199" checksum="864836F6114E8FE7" modified="2022-01-19" version="1">MGSFRGIWLFFLLSLCHLLGTECRIYELGARLLYGQSDAALAFLGNAGDVLQDKHFGFGLEGSLDFELECEPTTHKNSEIAIPNLWLLGCTALEKREIMEAGRTGLNQACQKLQFPEAEENFTMLCEAIPMQPLGQSPGGNLWDAHHSIHRDTFLRFVMLQCPREVPNKTRTRVAEAQCKGRLVLMNNKGYSHLSKDEGSLPPIYKTLLVLWIVLLALWIVNWFKFRQYSNRLHKLLFVAPSFKFLLLILTLAWWEVIAATGYENTSLQMCRDMVQSTEIAMLFMSMMLAAEGWCVIRPRIRNIRCVLIPGLFLVFLGSSICVIWVHNYFMAFAVCSIVFVIYRALKWCTYNLDYLTQQVLRSLHTAAEKRLRFRGVSIAKQLTEKRNIFVRLRLVCAIYTIVFAVTVTMSTFLTEYAWARTLAAELPEVAAFAALGLIFRLRDFGPFERIEVIQPKESSVLMLLPFSSKKCPIRQKIVLGDPVESSTEYSDDDGYEDDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z335</accession>
    <name>A0A8B7Z335_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6 7 8">Protein numb-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7 8 9 10 11" type="primary">LOC110983955</name>
    </gene>
    <organism evidence="5 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7 8" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022099372.1">
        <property type="nucleotide sequence ID" value="XM_022243680.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099373.1">
        <property type="nucleotide sequence ID" value="XM_022243681.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099374.1">
        <property type="nucleotide sequence ID" value="XM_022243682.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099375.1">
        <property type="nucleotide sequence ID" value="XM_022243683.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099376.1">
        <property type="nucleotide sequence ID" value="XM_022243684.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022099377.1">
        <property type="nucleotide sequence ID" value="XM_022243685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z335"/>
    <dbReference type="GeneID" id="110983955"/>
    <dbReference type="KEGG" id="aplc:110983955"/>
    <dbReference type="OrthoDB" id="10070446at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01268">
        <property type="entry name" value="PTB_Numb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000031">
        <property type="entry name" value="protein numb isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016698">
        <property type="entry name" value="Numb/numb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010449">
        <property type="entry name" value="Numb_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368">
        <property type="entry name" value="NUMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47368:SF2">
        <property type="entry name" value="PID DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06311">
        <property type="entry name" value="NumbF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00640">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017607">
        <property type="entry name" value="Numb/numb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="4">
        <location>
            <begin position="91"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="330"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="349"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022099372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022099373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022099374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022099375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022099376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022099377.1"/>
        </source>
    </evidence>
    <sequence length="650" mass="71053" checksum="A0A366028BAE202E" modified="2022-01-19" version="1">MGLKSFFFGPSHGRHKYNKNPPPDTGPPGAAAEAHPSSSSSAQSPKRNSRLRRSLSMKKLRSSFRRKEHAHVPAASKPHQWQQDEKLVRAGSCNFSVKYLGSIEVTESRGMHICEDAAKQLRASTKKKVRAILWVSSDGLRVVDEESKGLIVDQTIEKVSFCAPDRHNDKGFSYICRDGTTRRWLCHCFHSLREPGERLSHAVGCAFAACLERKQQRDKLCGVKVEFDVNKTSFTRQGSFRQPTMTEQLEAAAAQEAEKENEIQEVVGPKPAEMPFARPRQHAPDAMLLRQGSFRGFPNLNVQSPFKRQLSLRLNELPSTLQRQQNILHTHPEVPSEEEMVERHESEEVTPPTSPSASASFPQQQQQQLQPVPQQQQQPFQQQQPAVAVGQPGQAISISAACQELSEGLFELSSRDAFPTQPVPQQQPLAVQPTAAAALQQPVPQQPMVTTRQPMTAQQAVLAQTETNPWASQPQAQASLNPWDPPTAQMAGANGVSQAEKWLNQTSQTVSKVPAAPMQNGFGSSSSVGRQPAVHLQNATYEATQPMVIANQPPAMNFNNSATAPVFIPGRPQQQALAADGTGSSSVGISGGWTSDLSRTLPDSAAAQRGPTNGYSSSFEAKWEALPSNQTPVMANNPFANATKAFEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z3I9</accession>
    <name>A0A8B7Z3I9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110984367</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="3"/>
    <dbReference type="RefSeq" id="XP_022100199.1">
        <property type="nucleotide sequence ID" value="XM_022244507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z3I9"/>
    <dbReference type="GeneID" id="110984367"/>
    <dbReference type="KEGG" id="aplc:110984367"/>
    <dbReference type="CTD" id="10498"/>
    <dbReference type="OMA" id="GIGDGMD"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070611">
        <property type="term" value="F:histone H3R2 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000002">
        <property type="entry name" value="Probable histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000031">
        <property type="entry name" value="Putative Histone-arginine methyltransferase CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF10">
        <property type="entry name" value="HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11531">
        <property type="entry name" value="CARM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="267"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022100199.1"/>
        </source>
    </evidence>
    <sequence length="611" mass="67754" checksum="F9B204942A9E5397" modified="2022-01-19" version="1">MAVVFEGISLRSLSDHGDILQRTEAVLRLEVVTENEEPLVSIYNGANSQQMLRFSLSSEEVVCCQASKHTYLVNIQGRSVLLHFASDFELSRFHNVVKGAKHNSSKTTKKSVFKERTDEASSSQYFQFYGYLSQQQNMMQDYIRTSTYQKAMLQNSDDFRNKIVLDMGAGSAILSFFAIQAGAKKVYAIEASTIAEHAQKLVEANNLADRIKILAGKIEEVQVPEQVDIIISEPMGYMLFNERMLESYLHAKKFLKPAGKMFPTIGELHCAPFSDDAIYMEQFTKANFWYQQSFHGVNLTRLREEALQEYLRQPIVDTFDIRICLARSQKYTVDFLKAHETDLHRIEIPLCFVAHASGAVHGLAFWFDVAFCGTMQTVWLSTAPTEPLTHWYQVRCLLRAPIYIKQGQSMSGKVVLIANKRQSYDIDIELQSDSSGARSNNRLDLKNPFFHYTGQQPQPPTGSHETSPSEKYWDSVPQTAMVNGMADTNSMQVTPVQQGIGQSFNLIPLANAEPISHTGILPGGATQRQQTYSLPSSAGTLMSNASSLPFMQNGHQAAYTSSNPAAEAGGPGVANPFPVVAPAQFSIVGATDQLSLQPGTVIIQGQPGVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z4I2</accession>
    <name>A0A8B7Z4I2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110984225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022099872.1">
        <property type="nucleotide sequence ID" value="XM_022244180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z4I2"/>
    <dbReference type="GeneID" id="110984225"/>
    <dbReference type="KEGG" id="aplc:110984225"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022099872.1"/>
        </source>
    </evidence>
    <sequence length="205" mass="22996" checksum="57F188BF61AAE667" modified="2022-01-19" version="1">MSIMSYNGSAILAMMGKDCVAIAADRRFGIQAQTVSMDCQKIFEMGPRLYMGLSGLATDVQTVANRLKFRLNLYCLRENREIKPKTFMNMVSNLLYERRFGPYFIEPVIAGLDPKTHEPFICNLDLIGCPMFTDDFVVAGTCTEQLYGMCESLWVPNLEPDDLFETAAQALLNAVDRDAVSGWGAVVHIIEKDKITTRTVKGRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z575</accession>
    <name>A0A8B7Z575_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110984678</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110984678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100783.1">
        <property type="nucleotide sequence ID" value="XM_022245091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z575"/>
    <dbReference type="GeneID" id="110984678"/>
    <dbReference type="KEGG" id="aplc:110984678"/>
    <dbReference type="OMA" id="GKENIQF"/>
    <dbReference type="OrthoDB" id="5988050at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022100783.1"/>
        </source>
    </evidence>
    <sequence length="809" mass="91908" checksum="045CDB64A17E1134" modified="2022-01-19" version="1">MPRQKQWWFEMKNGRAFVMCSNSRLGEDAKPILQSNKMPYGAVKKLEVYKPSSSPADSGQSGKSEQNEDMIKIIFYEGNPKVLPTRNFLWQINDFCRNLRPSRESLYPTLDIVERFNSNIPGPSTEIDDDDSSPTGDDSATMSSSLDDEDLHTVTQDSIGDVQTDDSAISKKRRKLDNTINVPPLLNRNYSTSAQAAVPPSLSIQYKQEVQNAHLGHVKIYLKNLELGKQIRPVDKEFVAGLQTQMEKFPLDSTYQPLCVVTKTLPSPDMFKEENANGFKYGVIGGQHNFLATKALHDLYPERELYKSRWCSVYYGAISNEALLYLANTHNVIGRYRHEMTFKDKLQMCRLMMQEQTTSKDNAWKRKCSAILHEDMSGHFMRVLIHMAAQEETLYQSLMRVLSKYEKGELKDQALRKKERATGELDIKPYVFRPFLSLPASALSTLLTQLEKKEINLGTLQREGVILQKLQRVQRQMIFLLDARSWEELETKFPEHTTREVLFQYTKGLKGKEVSDSLRQFCRGLSKKAKLSTEEGTFLTEAPFQGVNRVVGFHLTMDVSNIKANSITELCGDFPGFQLTVLDLPKSWDEVSQDGFWATVIDINTKLELPSFTVAVLCKVAQQENVKKHLMRTDQFQEVETCYYHVADTKPEVGKLTESVFGIVIGHHGKTAVDRWASCQKRCNLILVNRGKTYKTEDGAEIDPGQKAMALYQELIRTYSAQQQWVLNACSRTGTGLLACMAESRNCVSVDRRADSKEHLQTRYNALGVLSKAKKAIQQPQPQPSVSESEDVWSFDSTFTDDELLSLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z701</accession>
    <name>A0A8B7Z701_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3 4 5">Paladin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4 5" type="primary">LOC110985032</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022101422.1">
        <property type="nucleotide sequence ID" value="XM_022245730.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101423.1">
        <property type="nucleotide sequence ID" value="XM_022245731.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101424.1">
        <property type="nucleotide sequence ID" value="XM_022245732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z701"/>
    <dbReference type="GeneID" id="110985032"/>
    <dbReference type="KEGG" id="aplc:110985032"/>
    <dbReference type="CTD" id="27143"/>
    <dbReference type="OMA" id="WLCTHPE"/>
    <dbReference type="OrthoDB" id="66369at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022101422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022101423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101424.1"/>
        </source>
    </evidence>
    <sequence length="878" mass="101007" checksum="7B77B8F58C280F49" modified="2022-01-19" version="1">MGTGASSASSRSPSPEMPRNNRLEESDRRKNSFGIEGGDKWKGHNVICNEVAPIIITKDCFEEFQCTLLAEKQEVTKGSIKDGLPEHTLVQGKYFMVADQFKGIDKMKTTEKQGAPNFRRAGGGFAVFGMGQPTALGLAKVMDTLGQEGCSELIVVCIREEPVLFLKRNEDFVSYTPREREKLCENIYTRIATSLGISNNEVALRKEILRYALRDQESEFYFYEDIDQFVDEPHKYCIYYEEHLKTIQEMYAIHTVSQTNARYLRMPMRTNGAPDEQVIDTFFDVLKDVPTLFDHQDTSTPGMVFVGHMGGSRTTFAMVLGMLVLAHKHGFPDVAYEQTHAMEEKTRNLEKGEFPVVQQLCGALPDGIQTKQEVDVLIDLCDDMSNIRGDIYDSKKKMEAIKQDYEIAGGSAKQFFLQRMFKYLERYCFLLLFNSYLHQQKIQMFCQSFQVWMQQHPILYRILGDMDSFEKDVNPAQQIAMGNRFLVADEYLGLDVLSSHREVKVSNFRRVPGLPVFGMAQPGREGLAKVIQHLVRQKYTHSSVHVFTLRGEVVLECDGATYTPRKVKSLSRNVFIPGITVNELEERELKLKNQLLKLNGPVEIYQDITEPRQAEQFSTILTLREMFENQQQITPELHYHRVAAMEYERSPPEKEFDFLVNVIKDLKDIYTDEDGPALVFNCDCGKERTTVFMAAAGLIIWHQKGFPVGVKLEEQERISVPQAEYTKGEFAVVMNLVRRLPLGSQVKREVDLMLDKCSETMTPMHYHQRETIFSTYNKVKSAKDEETAARLRHQSFNFLERYIYLILFNSYLHIERPNNWTSKFSTWMIETGRKIGAYETLDNLHYHDLDGDDAQIVSSIRHRWVNKGNKHGYQGTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z838</accession>
    <name>A0A8B7Z838_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calretinin-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110984784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022100960.1">
        <property type="nucleotide sequence ID" value="XM_022245268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z838"/>
    <dbReference type="GeneID" id="110984784"/>
    <dbReference type="KEGG" id="aplc:110984784"/>
    <dbReference type="OrthoDB" id="428774at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900271">
        <property type="term" value="P:regulation of long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099509">
        <property type="term" value="P:regulation of presynaptic cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15902">
        <property type="entry name" value="EFh_HEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051001">
        <property type="entry name" value="Calbindin_Ca-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972">
        <property type="entry name" value="CALBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19972:SF10">
        <property type="entry name" value="CALBINDIN-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="6"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="56"/>
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            <begin position="108"/>
            <end position="143"/>
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            <begin position="149"/>
            <end position="184"/>
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    </feature>
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            <begin position="218"/>
            <end position="253"/>
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    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022100960.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="34548" checksum="C8874612F204B110" modified="2022-01-19" version="1">MADSGEKDACLAKFRVKCENLTADEFAEAWHKYDRDGNGYIEGNELEFFFRDFIDIQESDECLQKAIATYMKIYDENNDNRIEMMELAEIMKPEQNFLLLFRSKEAPRTSKEFYDIWLQYDADRDGFIDKSELKNFLRDLSKVELSDEKLQTYTEAMIKLFDVDKDNKLSFKEMLKLVPVKENIFLQFESLLQGNIPDPSSHLLPTGSLGDKGKKLKVSSEEFKRVFKHYDKDQNNVISGEELSAFLKDLVILHAGSGPVVESTLDKIATDIMTTVDKDKDNVISENELKMFLGVTSDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9B4</accession>
    <name>A0A8B7Z9B4_ACAPL</name>
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        <submittedName>
            <fullName evidence="4 5">Uncharacterized protein LOC110985020</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">LOC110985020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_022245708.1"/>
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        <property type="nucleotide sequence ID" value="XM_022245709.1"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="KNL2-like"/>
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    <dbReference type="PANTHER" id="PTHR16124">
        <property type="entry name" value="MIS18-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16124:SF3">
        <property type="entry name" value="MIS18-BINDING PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF09133">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="378"/>
            <end position="462"/>
        </location>
    </feature>
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            <begin position="1"/>
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    </feature>
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    <sequence length="1496" mass="166821" checksum="C553ED0D211E50E7" modified="2022-01-19" version="1">MRRKRAPNLHNLIKRLTSPSKAVAATPSKKHTGSCVNDVSEVMHEEEMDSDRESVLDNTPRNSQGEMDHEWQDSCDVDTSELEPVTYSGATKRTRQTRSSSQLDVDPVSIMSPKDTPIPSGSGSKRKCVPQRRLLHDLRLATNRDLASRSPGASEQNMEYRMRPVDLHPGDKKSAKSDDECPEHEDTPQTGLECYTAPSGGPASREAAFAEETPVNQRAVGKTRSKGRRPDIGGVIKSLQAGQELGVDTPRSEVPYTEITLTSTLKEDETKQHKASSSPVGGPDENVDCKGADDKEDKIEGEEGRAENEDMREETKDTATSRDSAETEYKVKRSTRGQTERLTNKQPVLRGQRDKHEYKEMTQPETLQAPKKPETIINRWIIKPVPSCKGVCVEGHRIGDKEDQFWHSTSIMVRITPRLLATKSGALYRLAGKMDRALTMEQGFSESLVRSFQKGFPANWRELLYNHYLNEEKKKEQQKWSSSLVEKEPLGVTPGPRRSDVTVPDSLQKGKKKNPIEVTPQNLRVKDLRRSSSGRLIKPPLAYWTGQRVRHNTSLDVVEILLGSEDCTSSSINQISLQDSLELGPREKRAIKRSANTSKLHASSAGRKHRRQLKTEHSGADEEGSSCLDPEAKTSKGDGEYGHGAKLPASERKSKHSPRGTGPKRGDRRRIVQLKGTITDSSDNMEVPASKRHDDEDPLVLKSRRKSRYPRKNLKNRWREELQGSAESCSLDYPVADVETDNTASTSSVKPLEDPEINEVKHKKNERVKIQLSSQRQGSRQPPPPKKERARRDKGRVSSQPQPRACISPLYYQFSPPSEVESSHPASQPALGKTPTSRWKNIGDASSSIVGCASDLEKNSESRGRKVTNEEGEKMKLSRGDGSGESLGSLNLQEEILAVVEKHKQGRIARMRERSSKIRAPSTRDQSSVGKLPSASDVYELSDDEEDEPIKPKRVPYVPHGASTNTTTGESVSNWSEEGDKSVNMTWVTRAKPYRRIYGTLEDPQYRTDETSTETTTITTTTTGETDDSIVNPLNSDRETTTTKSSCDEEALMLQTRGQKKMLSTRQKGTRARMVSRPVLDQTSEDEQDQLSQKPFTSRSLKRTKQKCTPPETSSEDTDNTLEGQDAAISPRQQAASEDTDETVKVLDGPMQRGRSKKAIVIQRHQPRRNCKKSGSESDSHQPVKEARKPAAQSRKKPAPSRRKGLLEQSLEETTSECERWIPGQNGKGKVGSDTTSRDAHGTRRGAPRRLDVEAEPVRGTSRIEADGKSEFENKMGVHQKDEPAHPRSAIESSATKHSKQQSKQQANHAQAAIVLTAKVGTMKRKRQLRDLVEQHNRGYEDDIFDSTPFKKQKKLKIPLGEWDTEEDSHEGSVGKTPGSARFKTPSLRYQGVLPLSDKKTPYSNLISPGLLPSVDRKHVDQYIYGLQKKKKGHGLVQRPYTTKKPTGVSGSKGKPGRTSFTRALADKAGDMFDVTPVSDSDPDEDHDYYWSDEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9L5</accession>
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            <fullName evidence="4 5">Nuclear receptor coactivator 2-like isoform X1</fullName>
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        <name evidence="4 5" type="primary">LOC110985072</name>
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        <name type="scientific">Acanthaster planci</name>
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            <taxon>Eukaryota</taxon>
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            <begin position="546"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="835"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="852"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1575"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1758"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1852"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1900"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1928"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1950"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1964"/>
            <end position="1984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="2035"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2058"/>
            <end position="2075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022101494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022101495.1"/>
        </source>
    </evidence>
    <sequence length="2092" mass="226285" checksum="0B050BDE51CD0DF8" modified="2022-01-19" version="1">MSAGGAMNNQNPRRRKRPEKGPGSKFLGEKRRREQETYLEELAELISANLSNPESLNMMPDKRAMLLEAVNKFRHYRLQQQQQDLEQGSEVQHSHVSSSKPGMLSSDSLGNALLEALDGFLFVVNSSGEIDFVTENVEMYLIYKPEDLIGMSIYNFIHIGDHNQFHNCLLPTSTPGMWSQDSSSPSSRNRSFTCRMLKKPVDEEDTPEAEQHYENLKCSAILKPKEDGQSSNSTESDPPSHLVCVARRMEDSATTGGNAAGSAGAAMLLGGVGEDFTTQLDLKAVVMSVDLSRLHPPHYAKEDLVGQIIYKFCHPSDRAELKKHLDEALEQGTSSSLMFRFQIYKDTWVYVQTTSRVYRNHSSGKVECFLATHSVLRDDASSGKVMKQSNMLGMTSTSGSNSNTNRIMEALSNFNNNSRADLNRICSMVLKRHQQNEHQHLQQQQQHLQQQQQQQKGIGFSSNSKVPTASNPNSLPTNAQEDLDLLKRSSLSTLLQDTSVRNCSSTMETASVYPVSHSSGGKSGSSSGNDRYPIPEKIQRMEHSPSDSNIASSTEHGGRTLSEQSDDGDVFLSDHQNHKKGRFPDKSRPKGTGSSSGGGSGEGSGGQVDRDSPNLSPDTNEGVKETTSSTLSKNTLLQKLLQDDPEDDKSDTSSSRSNSPLCTEHKNTSEDEKMDEKTFSQLLKSDTSSIGGGSSSSTEKPFKSSSESSERPEGNSEQLADADGKPRTRRKSIERENLILSKLLDGDSGSMFGSGKLPKEQPGFVCSNVVSTTTVLQKGDSDKQVAKSDKNTDSGSSNNNSNTKKRKNVLLQKLLMEDLPTIEKNRDIEATCQESTTSPTVTTTKPGVPGSQKTNTEENSVDSFGNESEAVMQQFLQDAPHLPEDGDSNQPNMFMEILKDLEGVHDLPEAHMQSLMNAPDSSCQTQTRYPAQNNATLGSGVQTPQSKLPMGPETLPGPGPHQRPDSSGGLANATLMGQGVGHEPTNSMHSRKSPGVNSQHRQPVKRTNSRDSYNSGSGGMHPSAGNFGRFGSSQPDCFSMEGMQNVMPPNQTAPMQTSMSQLPLQGTGQQHLYDQDHIQENLSGNNGDEHILSEEDADLLQQLQQVLNSSNFLPELEGNFDMDSNAGLNGLVGMDQAQPNGSNMLQGMLSGQTSTQPPQSGSYQTQSSTSMGMQQQQQQQQQQQQQHPPQQQQQRSHQQPQQQPQPKQQQPHSMIGMGGGGARMGQGGMVDMQMMGAGPNASTGPGQPRFPHPQQQLQGTQPMQYNQMNPMQQQLQHQFTQQPPQQQHGPVPPHSMPLQPQQQQQQQQLASGPGKPSQVPPPLSSATGPGGFTRPPAKQLRQAILMRSRLKEQQQLQQQQQQQQLQQHQQQQQQQRQWQLQQQQQAMRQQHMNVANAATANHQLMGGNQPPPPQPQPQQQQQQQQASPMGMPVGAGSPVMNPMQQNQQQQRMVQQQKHLMMLQQQQQQQTFTGPQVEGGGFPSLDTQAFQEKLSDVLNPTGGVLAPNVSIQKSPGPYGPQMPGVGNRPMPGGNQMMGSDTRQQMGMNQPFPGQTGSSRGGPDFMFGNQMMQQGRPGQGGSGYQGGMGHAGGSGGTNQNIFNFQDFNGPGGMVSRGGNMPGNPQHMMPNSGMMGPMQHQQGMGMNPNMPGGQHGIGLNPNMSRPNLGNPRQQTPPLTRSLSLPTTNFVSGGNANSLSPANRHNQYMQQQQPQQQGGFQGNNLRGSQFGGSSGMQPHFSGNSMNMQPGQMGGSGGSTPMFSSPSSGTQMRWSGPNGGAIQRAPLPPPHQSQMFPGPAGGGVGGLPQSGEMMRGMANQVGGTQDLQNMTNRRLRRGDSLPANPNMMSTPPKYPLQGSTNSSIPVASNLLGQNTMALGGQQQQQQQQAPGDATNTSNSYLAPVSSTSNSGNNSNAGSSNKNRSTPGTNPSNLDMLSLSMDLFEPEFFKPDGQNPIASSTTNATSQPDSTSTATSRSSNSNSGGNPSGTDPLKTFAEMQSNEEAKLRYQEFYKISGAQTAPDANTRVTNLFRNQLTSGAVGRGVGGQPMGGQMQQTGGGGGMVPPQQQQYGNEEQNQQESGEGDGKSNSLLQKLLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7Z9Y5</accession>
    <name>A0A8B7Z9Y5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9 10 11">Delta-like protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10 11 12" type="primary">LOC110985225</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10 11" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022101781.1">
        <property type="nucleotide sequence ID" value="XM_022246089.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101782.1">
        <property type="nucleotide sequence ID" value="XM_022246090.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101783.1">
        <property type="nucleotide sequence ID" value="XM_022246091.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022101784.1">
        <property type="nucleotide sequence ID" value="XM_022246092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7Z9Y5"/>
    <dbReference type="GeneID" id="110985225"/>
    <dbReference type="KEGG" id="aplc:110985225"/>
    <dbReference type="OMA" id="CTFTDQT"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049:SF22">
        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665677" evidence="6">
        <location>
            <begin position="19"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="54"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="7">
        <location>
            <begin position="134"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022101781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022101782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022101783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_022101784.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="23588" checksum="831263CA7074CDD7" modified="2022-01-19" version="1">MQPYVVLLALCFIGLVNAVDINCDDNPCQNGGTCRKFIISFCSCPLGIHGDLCEINPCEDADDPCQNGGTCSNNLLSRNYTCSCPYGTNGRHCENIPCKGDPCQNGGTCYPSLFSNKYSCSCTPEYYGDNCETRNDKCDVNPCLNGGTCKVFGKSQYCVCPPNVNGKDCEYNPCAKKPCGTGTCSSIFQNEYLCFCQDGHIGKCCGGHDAPKPSPDPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZAE1</accession>
    <name>A0A8B7ZAE1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium-coupled monocarboxylate transporter 1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110985712</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102623.1">
        <property type="nucleotide sequence ID" value="XM_022246931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZAE1"/>
    <dbReference type="GeneID" id="110985712"/>
    <dbReference type="KEGG" id="aplc:110985712"/>
    <dbReference type="OMA" id="YLIFTCM"/>
    <dbReference type="OrthoDB" id="10321161at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF40">
        <property type="entry name" value="LD47995P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
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            <dbReference type="RuleBase" id="RU362091"/>
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    <evidence type="ECO:0000256" key="12">
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022102623.1"/>
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    </evidence>
    <sequence length="620" mass="67353" checksum="12E57BC34427C9B7" modified="2022-01-19" version="1">MVELGPTFHWADYLIFTCMLATSAGIGVFYAVRSRSQNSSGEYMLASRQMSFFPVAMSLLASLFTGVFIQGSVAETYYRGAILLIGSIIPLVISGTISGRIFMPKFYEMKLTSVYQYLDLRFNVPVRNCCLLIGYLYMILHSGVATYAASVVLTTVTRGKLSVLLSAVILSVVCTFYTVIGGIKAVLWADCFQMLLIFASLLAAVLQGAVTLGYTEIWNLNLEGGRLNLFEFNPDPRLYASFWTVFIGGTFSWLPTMAVLQYQVQRYLTCKSQKTAHMSFGTFIAGCIAVTILCVLAGMALYARYADCDPFSSGSLPIKDGLLPYYILDAFKDLPGVPGLFVSGLCSAALSTTSSILNSIATITGEHVITKIWKDLPDMKYLFITKMLALFFGALNIGTVLLVSAFGELLPALIGIIGVTNGPVCAVFILGFFFRRANAKGTLVGFITGIAVGFWLFIGSVFYQPPIPSLSLSTEDCPDVMTNTSVIVTTMTMDFVNVTAAVSLPQASSSSIVELYKVSRIWYPTICILTVLIVGIVASLIFDAFFDRPKVDSLLLWNWRKSCCCCLTSPATVDDEKSLFGITSDIMSDITVENGEPAGVANPACVGCEVCKSPSRTTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZBM4</accession>
    <name>A0A8B7ZBM4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ataxin-2 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110985484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102225.1">
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        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SM-ATX"/>
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        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1"/>
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            <begin position="958"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00007503"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01272"/>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
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    <sequence length="1096" mass="119811" checksum="3DD4E576413CBCED" modified="2022-01-19" version="1">MQQNHGKRGRSRGSARGGRMGSRGPPPMQHAPIQREVLQGIYTNERFTHVGASLMGCQVQVQVKSKKIYEGILCTISPQAETVLEAAHMLNQGGDNADSVPILNKIEFKASNIVCITAKHVDLEYGVRDNEDSFVTDAEIARRQNGQAGERELKEWQGSPLEEDMSLEPSAGDGHANGWSAEEMFKTNEARYGVKSSYDDSLPEYTTSIDQSNPKVFQERKEKADRWAREIEGSARSESDDITEEEKFSAVSRSSENTGTTRYIPPPMREGSRGHSPQHGPPQRRPQGPMPRLPGQGRPQMTSPHHGQPAQHPATQAQGHPHAQSHPPHQPVGQQQPPLSGHMYPSVQTRLAQPGPQHQHQQQQQQVPQQSQQALSPHQLQATSSHQSQPLQQQQQQPQQPQPPLPQQQQQQAPPQKHYSAVPQPPAHVHGNPRPPPPQHQVQTPPRGQPPTQTSPCPPGFGSQSPRSSPLPNVDPASPNVREEKVPATVSEERQPSLDDSNSRKTDPSTVDRTADSTTVSPEKTHKNVQEKTIADLKEFSSSFNLEGKPTEEEAASIPSTQPAAAAAAAAAAVASADTKQGTAENTTPTVPAATEERDAKETETSSGKSSPTQPSKEKEIQLNPLAKPFVPTAAVTSQRGMPTKTPTPPRPQSISPSSIILQHPNQFAQPMGGSYILSSGQTYPGTFPMSQQTAVAQAQAQAAHMGPKMMAKKGFQYASSATNMPRPQPPTDLPTHVIPPSVAAGQPLVSPMGFQHHPGQMIPFQTQQGIPGPITGQQMLPQPGHYQMYPKHPHAVPFRQMQPQPSIQGIAHPQPTPHIHPLSETNMQGTSPVLVSGTPLQAQGGQVQPQIHTQYQHQSAQQQQQQQQHAPQPSQQHQQQQQQQPPHHHHPQPVVHLSQQQQQQQQQQQQQHQHPHAQPHSTPPQQQSHGSQPSPMAQPAQQQQQQQQHRPTPSPVHHMPLPQHQGHQPPHAVSQPHHLQPQPQQIVYNAAPMQQGHPHMAAQSSQMQQFGGPHQQYVSQYITSTPPATNITSVTQLHAHPHPHPTQANVTLVPQPGQAMNHMVANPGPFQTHILAQTQAMGQAHGQVPAYQHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZCA9</accession>
    <name>A0A8B7ZCA9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein LOC110986028</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103303.1">
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    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
    </feature>
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    </feature>
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            <end position="1104"/>
        </location>
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        </location>
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            <begin position="1078"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022103303.1"/>
        </source>
    </evidence>
    <sequence length="1328" mass="149569" checksum="7F8FB566DBE2D658" modified="2022-01-19" version="1">MSYRSRKLLQTGQGKRAEADAHAALRPMVAPTVDSGPVNSLGFSIPIPSIRQADIQEGLGDITSRLNRALSQYANVYDDDEVSEDVDWATEGQAVSRRVGVQDERKEFQARYESITARVEAMERERTELMNSMAEWLEAEPVQWIPTPDSQATTDDSEPSRASFGDQLLNTKMEFEKLRHMNHEKERLGSQGQDTELLQEESSKLQMKVITKFKKLYETRKLAATRRTFGAHWKHASDEIVGLLRRIRSEGTDHIDALEDEIEKAMTAIQRQAEEMIRLEGKIREKEEMVEKWSTENAKLTNDNLLLNSEKEKCRDIIRKLKKALIEERRKRGTPTTDEDVENIGEGKVTQKLEEKVPQQKDQLGARRAPAGRDVKGERVICRLCRRRIEGGAEMGRSEQAEAKATERSDEAELVERQALADDVIPGDLETLQEENNWLTARVNQLEQRLIEKETQMMKLEFQLSELMEAVKTSSPQMIETLSMTDPVSAKGVNRAGRDKQAPGTKQMEERPSGGGTDGRESSFVASSKPAAGRKTSSLTVPRVTKPSSKQSAKRRTGEQQPIKQQSQSNLTQAAGASPQRKERRDYAAEILQLTEERDKVQGELVTLKGQLMRAQRELVTLKYASSAPASMGPRGGPLQGPEENGGEHRHDVPGRSKEGSGVSLSTTQIPSKTTTAQETPAKPKPQAVVKYDDEFQAYAELMRKDQDSRPARKMSRPCQKPKDTGRGKQDKRDQSQAKEGEEEQAKDLVQMEEYLTFDQGMQTDPQMDPLGQWSYVPSLKKRRKIDPLPVLTTRSSTDTPSDKAPIAQPPIEWTHFDPTGPITPMADHKRASISRQMRAGEEPATVDTGGIVEFVERELGRIVQGINGFTGYLKRLIQREVADVIVANQDIRRRLSEATLRKLDQGNKDSAHPSADGGRRSRALATPIRRGRFEVMKDNRPSKFAAKNAYASLQSGERRFFHSASPIPSWNIHSKIPSPSYADYIGPWSTFARDHIAMADEAATQRTLASPHDTVCVRLQRQIEMIGHHAIDVLKGTVVFFKETFTRQIEEYNTIHGAFGIRQELKTLMAPSVTPSENRDGITDSRKEVAEAEATSDRAEVPSLEPPLKLTRSISHNSFLEFRNVNYVQDNRRVDFKTSPKEYPLQTQSLSSIQSSHRYLPALSLYEKQKPRNRYEVELPKATLPRRGLVTLEVKDAVANMAAKGVDTKRRSRPVAISHRGLLARQREILAKQGTTPQDARKQGTDHLTTTLELKQHILQLQANQLYQNTEQNSLPTVELEADNRKNLPPLDNERRRIIIHAQDQLRGTVQLWDKYAGLLSDGRSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZE58</accession>
    <name>A0A8B7ZE58_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein LLP homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110986409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the learning-associated protein family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103948.1">
        <property type="nucleotide sequence ID" value="XM_022248256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZE58"/>
    <dbReference type="GeneID" id="110986409"/>
    <dbReference type="KEGG" id="aplc:110986409"/>
    <dbReference type="OMA" id="YGNYPVW"/>
    <dbReference type="OrthoDB" id="6257894at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001099">
        <property type="term" value="F:basal RNA polymerase II transcription machinery binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097484">
        <property type="term" value="P:dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018784">
        <property type="entry name" value="LLPH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34253:SF1">
        <property type="entry name" value="PROTEIN LLP HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10169">
        <property type="entry name" value="LLPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022103948.1"/>
        </source>
    </evidence>
    <sequence length="167" mass="19444" checksum="7FFED8862FF02ED4" modified="2022-01-19" version="1">MAKSIRSKRMRKLRAIKRTRNAPREAKRLKKILGLLKPEEDDPEKNVYKFSDVRDMILNKPTVNQASGTAYDLRFVPDRDKIKTDAAQPEETTMDDDTENKSVTDPERQETMEAMEEDGEAKPKQKGLQNEHGNYPIWMSHRRIKKITRKGRPNQYKLKRAGTGKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEG4</accession>
    <name>A0A8B7ZEG4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Acid-sensing ion channel 2-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110986461</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022104029.1">
        <property type="nucleotide sequence ID" value="XM_022248337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEG4"/>
    <dbReference type="GeneID" id="110986461"/>
    <dbReference type="KEGG" id="aplc:110986461"/>
    <dbReference type="OMA" id="DIYREDT"/>
    <dbReference type="OrthoDB" id="8065060at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF222">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022104029.1"/>
        </source>
    </evidence>
    <sequence length="496" mass="55857" checksum="139ED673EBA3F6EB" modified="2022-01-19" version="1">MGCYKRCYLRQWALTDTDLHGVKHIAGEGGILRRLIWAACFLAALVVFLHQATLTLIHFVEKHHVTKVDISYRKKLDFPAVTVCNFNKYRESALTDRDIRNVGYHLGIVDEDHNLINPYLYTEEFRRKMAAVDWSVHDIDDEYNMTEFTNRTGHQLDEMIVECSWRDEPCSPDDFHHIFSHLGNCYTFNHVALATERHSSISAGAANGLKLTLNIQEEEYTPSNDLHGAAEDAGIKWMLHHPSEPPYVKELGFGAGPGHHTFVAVRHEEVESLPSPYTPCMETSAGFLDHFDHYSLQACRIECETEVVVQRCGCRLVEQPGNAPVCNPAETHECAQAALVHAVAGHGDQACDCSSPCSVESYPFTTTNVRLRAKYIERIYSNTTHNFSADYIQNNLVLLSIYYEALNAEVIEQLPEMTVPSLLAALGGNFGLFLGASVLTIVELLEYVFDELTASCTRRKTSGRISNAREILTVRAAPISVIDTEKELEHGRQWNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZEK9</accession>
    <name>A0A8B7ZEK9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein LOC110986100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110986100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103432.1">
        <property type="nucleotide sequence ID" value="XM_022247740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZEK9"/>
    <dbReference type="GeneID" id="110986100"/>
    <dbReference type="KEGG" id="aplc:110986100"/>
    <dbReference type="OMA" id="PFCIDPR"/>
    <dbReference type="OrthoDB" id="10020456at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042333">
        <property type="entry name" value="LRAD2/Mig-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652:SF69">
        <property type="entry name" value="CUB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24652">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR CLASS A DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034373749" evidence="5">
        <location>
            <begin position="28"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="6">
        <location>
            <begin position="47"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022103432.1"/>
        </source>
    </evidence>
    <sequence length="383" mass="40635" checksum="69FCB17DF0D41C26" modified="2022-01-19" version="1">MNWLNEAFFVICCVYITMSTTVNVATAQNHHVTAYMDRRERNKEYGCGDVVGDTVSGAISSVIPANAAGLNCSLTLISPPGTRLSLTITRLHLVSPNLNTCDGNRLKILGGEASGAATSLLPSFPNGLCGYTKPSQSVESLDNRVYLLLESIPTTIENTFNLSYESFKTTPDDECFVCDVGGSRSEPFCIDPRLLCDGRQNCPGNSEETAANCMATTSAPPSGSGSIVVIVIVSVLAAVLIAVMIFVVLAVMAKRMRSKRNQGSVRRSERASQSLTGAPPSLAVNLDHMRLHGENEDLPGSYEVAVGSPMPLHPLGGPPLFTVDGEYRSEAPPGTAGPLPGAPPAYSTLPRPMERSLQIAENTNPISRSRVPSTNDELAPGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZFK2</accession>
    <name>A0A8B7ZFK2_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcineurin subunit B type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110986313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022103777.1">
        <property type="nucleotide sequence ID" value="XM_022248085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZFK2"/>
    <dbReference type="GeneID" id="110986313"/>
    <dbReference type="KEGG" id="aplc:110986313"/>
    <dbReference type="CTD" id="5534"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="128"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022103777.1"/>
        </source>
    </evidence>
    <sequence length="170" mass="19383" checksum="CE9635FEBA704EBD" modified="2022-01-19" version="1">MGNEQSLPVELCSTFDTEEIKRLGKRFRKLDLDNSGALSVDEFMSLPELQQNPLVQRVIEIFDVDGNGEVDFKEFIQGVSQFSVKGDKESKMRFFFNIYDMDKDGYISNGELFQVLKMMVGSNLRDTQLQQIVDKTITNADTDQDGRISYDEFCAVVGNTDIHKKMVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHH7</accession>
    <name>A0A8B7ZHH7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Tubby-related protein 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110985751</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022102711.1">
        <property type="nucleotide sequence ID" value="XM_022247019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZHH7"/>
    <dbReference type="GeneID" id="110985751"/>
    <dbReference type="KEGG" id="aplc:110985751"/>
    <dbReference type="OMA" id="MYHRDTG"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.90.10:FF:000001">
        <property type="entry name" value="Tubby-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018066">
        <property type="entry name" value="Tubby_C_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF7">
        <property type="entry name" value="PROTEIN KING TUBBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01200">
        <property type="entry name" value="TUB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="5">
        <location>
            <begin position="257"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="160"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022102711.1"/>
        </source>
    </evidence>
    <sequence length="506" mass="55225" checksum="C9B4C40648869EC7" modified="2022-01-19" version="1">MYHRDTGSSLSSSQGGGWNNNSAPPGSIMDDEQATSPFSLREQKLEKQRALLREKKKKYNQPMVVQPNEERQGSGGKSRRKVPEETRPLVSPTHSSSASDGLQGIDGPASFSLNSSLTTVQVLTVGSSSTEDDDDIPTFRETTETEKKLKAMGISQAVNYEDNEESGTPIGVMNTSGHPGGQMSPPPAYPTNQPSGFGNINTTSSTTFNTSSGYAGGYTGSESGYTSTQASPPAQETKTLGASGGGLDLSDLDAFVLRPAPQGLTVRCRISRDKKGMDRSIYPTYFLHLETESGKRAFLLAARRRKKSTTSNYLLSTDATDLSRDGESFTGKLRSNFMGTHFTVYDNGISPNKPGAMADGTNTRQELAAVIYETNVLGFKGPRKMTIVIPGMTLDNERVAFRPRKAHDSILDRFKAKNMENLLELHNKTPVWNDDTQSYVLNFHGRVTQASVKNFQVVHSNDPEYIVMQFGRVTEDVFTMDYNYPLCAVQAMGIALSSFDSKLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZHX7</accession>
    <name>A0A8B7ZHX7_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Probable E3 ubiquitin-protein ligase HECTD4 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110986753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104607.1">
        <property type="nucleotide sequence ID" value="XM_022248915.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986753"/>
    <dbReference type="KEGG" id="aplc:110986753"/>
    <dbReference type="OMA" id="HDYHLQE"/>
    <dbReference type="OrthoDB" id="5986060at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13735">
        <property type="entry name" value="SPRY_HECT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043366">
        <property type="entry name" value="HECTD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035781">
        <property type="entry name" value="SPRY_HECTD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46435">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46435:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="3546"/>
            <end position="3923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1441"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2834"/>
            <end position="2877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2968"/>
            <end position="3007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3035"/>
            <end position="3059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3235"/>
            <end position="3308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="3683"/>
            <end position="3708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="2841"/>
            <end position="2850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2977"/>
            <end position="2986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="3289"/>
            <end position="3308"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="3891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022104607.1"/>
        </source>
    </evidence>
    <sequence length="3923" mass="427442" checksum="AA94737D5EC4BB76" modified="2022-01-19" version="1">MLTGQSTSSTATKEDTSTTSCGLTLKLLRKTPIFTCGNSVVMLTAPPGSNSNSSSRSIFNAGSGLSAARTLGSNLCFSAKDGSFNTRVDFVDAPTCSVARGSPIVGLGVCYDATNNVIWTCSSDWVDQWHNPGLRAPHHVEQQMGMGPALEPVPEDSLISIPGIVKMLLHHVGSNCCHRIHSDILQSSLGQMLMRQRTLDVIHLRRVGDILEQALKNGDQPAAQCMLIVLQVLFKCHTFRSSKKDDLESVQRAGSLAWQVLVEAKDATGCVGLQREACNTIIAGLTVLYRTEEEQNALMHKLLLEGEANPALGRLRDLILGVMGQLLRLEGSDSDLSGRLKGDLVQLILKTSIKEACILIRRCLQASSEDFENIVSSVPIASPCLQYMMALQIKLLRDGALCKPKAEEGTTPTAGKSSPSLEDLQQSILNLASSVFKGCNEVLESLVQVCQSIITASPVADWDSRFQGLERVVKGTVLGHLLPVLITALTHENLQSLSLAEALIPQVVQLIILTSQVSQMMLKCYQLRDSLSNEDVTSPGPDSIPTIRATPDTPVQGFLAGLKIPAPWATGKTVECIHPVRDNYKFRETVHIPGARCLYLRFDPRCASQYDYDKVIVYAGPNSSSRKVAEYGGNTYGFGSRSVLGSGWPKDLVKVEGNTVTFTFEMRSGREHNTPDKAMWGFACTVRAQESTEDASGGMPFLADLALGLSVLGCTMLQRLYRGPDKSTQEEQSEHLLKSKLLQRCVWHPQAVKQTPKPAVATVAEAAEPSGQSDSRTLPRIKLSADIMQRLQALSGRMAPHLRPSIREVIQPAALEEAIVSAALKHLDIEGAVLLLGEGTVSDQQRGSYDFLCQVMNGVYRRIYAIQRQLQLLAELEQKWDHDLDEMRNGTLESGSSFFALYHQQENKMRELELLAYLKDVDFECADQEGAVKLLREKLEQEASLKPSDEPKLSMPKTKSLVQAILERVELLLHVTIATKSLQSHPPSLSRSVSQHPGSQQRGFVAEPSVPPPSPPFTRSVSLPMELEGGKETNKSSSRTRWQSRRRGPLSLLQDTVQSEGKQADKQAHTLLLDELFSFIGTNPEQAVSLESFLSAARVRSRRGSTRKQALIHIKQLLLAASKVGGAMHLLVAVTSVIQNGPRVNELACGGMVDEVQQAFSETMTSVVTLAGAHPVACANSIGLLCTIPYTRREEQCLVDSGLVQVLDQLCSLGSGSGGSGGISAGSSESQTTKQLVSALAWAGFQVLANRCVSWEADETCHDALGHAGLARQVSSLLTNHLARATESSGNEAAGSEALQEVLSLLNELSRSRMGKAILSQPACVSKLLSLLLDQRPSPKLVLIILQLCRVALPLMSAEDCASVQLPCWGQEVSTLLGGADAASAMAGAGAEGEKEGEGEEQLGDPPAKIASLLLAKLGDYVVPGCQTTASTDISNSVSVDGTQVAVPSSGDRDKGEESEAQDGRISVFIHKREDQSSHEVIQPLLSSDGRPFRLGSGANMEKVVRMDREMTKYGKAEVFTEEANTAIRKASKWAQGGLVVSTGPPVENNNDVANENGKEKKKVATEVICREKNAELARTDPVRPFISGHVANSMASEVIGLLHSLLTAPETHTALIWASAVERVLSHALTLVSQLTSHQTSHISLLNSQPQGESVTRLMSICRQVVAAFCALGGFKESIKVGSKVQVTGEGSRPLLGHVISISEPQGVATVEFVITKDMTIPRANNTLEVPLSRLQPPSSETLPLQQLSMTERVVSALHSLLLPRKERGMSPVTVALPAVGDGSSLAMAACRVLAEIRSRACAVLALHMKEPSFATEFVKQSSVPVEVLKSLAQQCSSGERVSVVEAQCQRLRMLYRDCARPPPPPAKVTSRMSQDISWNPSRSFPPPRACMFSHNQTAVTFLGDANAGSGYPRGVMCYATQPVPSQAPSFYWELEICSNGDSGDESGPSVSFGLAPHAEKKEGAWTNPVGTVLFHNSGRGVHYSGASLLQWKSLRLDVTLSVGDIAGIGWERDGDGGSHAPGQQARGRVFLTYNGRRLPATLDGVAGGMWPVVHIQKRNTRVRANFGARPFCYAEGRQHHDAAVEATDPREEILANFSMLPFHTLEESEEGSGERAALDVPPGPLEAVGETTPAGPPCRLAASPKPLTEYDTDESVNYKLRQGYDSFTNMGADVRILSAGQDDAREDEEEGEQEAHEDFHALLVKAWESKVFPVIRRRFRNEAERRSGLEQIKGALQLGMTDIARQTVEFLYEENGGMPRDLHLPTIEDIKTEAAKFTIDKVRKGTTVVVRQPESSGSVGSTVVPKFAVRAMLKTFGLTGMVLDIDSRQELVQVETYLRSEGVLVRYWYPLDVLERPQSGYRRGALTGLAALDISNINIHRELLHCESTSARMSCRTALMEFLGHCQSPEVIEVIPCSLTSGQASASPEHDISHLQLLSNQLLGSPQPDGALQASSLLTAQWLHQCLASNTRCLADIFYQDTQVLRRELFIAMATAAHMGEGRLLELTNQLCGVLQVAPHHFPCEITTVTETKVNTDLQFPGAAAVIVSCQQDPKTARKEASLYQAPWARVFCYGIGHRVKKTGQTALLEVVSYPADAAINSSAGLSAPPSHNIDPYPAVVLPCNRLHLRHGVSPVPGYVLSLHGLPSEFPLAMAFIETLVGCEHQIGSQKIEGTDEIVIDRLKDIPTERQEILKDRPVHIPPRVISRAAELLTHYLMTAKVPPLIKEYLFHMLAQLLRTLYKRESFGESIASAATTLPFVVITQLVQLNMELRKLFEHESTSGVLSSIAPGQQSTYFQALMELCLALAEVTSPPGLGAQLAPSAHATSSVQLSPQAAAKRKKVKIRRTGTTVKRSPRPSESDSGETSASTSSKPEEMLWFHRALTVSLILRYLIDGNLQGATVTRDAILDAHQSNSVPSTHSRLLVITGIPMTLEEQTVRRAIERACSSHGGLYKQELWIPIQDQKQPEDSPDADTSIQTPVNLQRPDLPPGAAVGTPDPSPVAEASVNTALEDQAPDTQQGAAVTPLADQHAGLLTPPPEGEATPVDGQDRDTLNHPDEAKQLVKGYAVLEVRCKAKIDSIENALLTSKEVTEAMQVETAAILDVSPEDFLTVSAVNSALQAELTDSGEFSEYLRHKLLTDKPPRELRPLAVQALEQVFYSCLAAEQGFKLLSELEEKDMDTAEVTLSKEQMLSLAPGNLLVPFFGEVKGSKHTAQEEVTLVLEKYGVNRLGSSRPKKSSAKPSKDQSRTVNRRGSKTSKEKLAAADVSFKSKSASPSDKKSKRPEKVARDAPEKRQLEEGRAKQEAVPERALCLAGFLQFVTEQAQDNAVPVWKALMACSFDFHFDRFASLNHSDTPSYFKHWTHDMDAALVRYVDRLCRKFSITPGRLHPHEVYFTEDDLVNPAFAPLQGVPLEVLRLRFALLQSLSNNLEAYFLPLVDLRPSQTLSLSTAALLSRARRLLFYDTKVKFFNAILDATAQRNLDQAAPEITLDPLEIVGADAQDCLATQFCQAARQLSIVPSSKLCVKIASGGDPTYAFNVRLTGEEVHGTSGSFRHFLGQVTRELQNSTLGLLVLCPSAGTGRNKGRYLLRPGAITFPEEKLLEFFGQLLGIALRADIPLALDLLPSFWKCLVGAALDPERDLEEADCITYGYIKKLTEVQSEAEFDALCAEVSSHHASDLESPDPDPVPERPASPSSTLQMGQPAHNLTFVYHSLAGDEVELCADGRTRRVSWKNRQQYISAIRDLRLRELASPERMLAVRCGLASVVPIQLLCMMTPFDMELRTCGLPTVDLDFLKAHTMYQVGLVETDTHIQYFWSALESFSQEEIGRFIKFACNQDRIPCTCPCQDGEADTSHVPPYPMKIAPPDGTGGSPDTRFIRVETCMFMVKLPQYTSQEIMTRRLLYAINCREDPLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJ17</accession>
    <name>A0A8B7ZJ17_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Plexin-B1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110986956</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022105007.1">
        <property type="nucleotide sequence ID" value="XM_022249315.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986956"/>
    <dbReference type="KEGG" id="aplc:110986956"/>
    <dbReference type="OMA" id="GATNWIY"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11236">
        <property type="entry name" value="Sema_plexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000131">
        <property type="entry name" value="Plexin A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000868">
        <property type="entry name" value="Plexin D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031148">
        <property type="entry name" value="Plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041019">
        <property type="entry name" value="TIG1_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041362">
        <property type="entry name" value="TIG2_plexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625">
        <property type="entry name" value="PLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22625:SF44">
        <property type="entry name" value="PLEXIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24479">
        <property type="entry name" value="PSI_PlexinA-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18020">
        <property type="entry name" value="TIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17960">
        <property type="entry name" value="TIG_plexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034235402" evidence="15">
        <location>
            <begin position="32"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1253"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="17">
        <location>
            <begin position="25"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1346"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="1377"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022105007.1"/>
        </source>
    </evidence>
    <sequence length="1381" mass="151651" checksum="5A2C927A5C14B4CA" modified="2022-01-19" version="1">MRLRRQSQAALWCALRLLLSIIYVNVCVTLAEWQGDLSAYELASFNNPDQEDVPRAQSFNHFALSDHGDVYVGAVNWLYRLNSRLEQIQNASTCDDSMPYNGIPCRRTNNYNKILVIDSTRPNSLITCGGVYDGICQLRQLHDIGVAVTETYFSVAGFEDATTVSLISPGRYGQEMLYVAATYTGENLLFIFAAIITRRTLKIDDIFELQLNSDAILFNNRALNGDFTVTYVAAFAYTGFTYFVASQKEDLRYVHYVSKLSRVCQSGFNLDAYTEITIHCNGSDGSGYSLVQAAHFGPAGPDLAASLGLHADEQVLYAVFAKNQGAPGTSDVPTDHSALCVYRMTDILAGFKEAVRGCIQDGAAYSVGYLDGSFCRTLSGISPDEFLCDPVADGTIQLYKYAKGTTPVSSAALLEVPGSLMSSIITSVELNHTVAFIGTSRGKLLKVHIKSNATARMYERVPLDTSPVLTDVKINDATREMHLLTEQKLIKMRAENCDQYITCETCIGTDAGNDGDPYCGWCTLERKCSRYSDCDSPTVSTRWLAYNAAQCINITDVAPYDSLPITVTEQQIVLSVQQLPALATGQSYECYFGPYRSPATKTGDMLTCRSPPSDGIPAIQQGDDAVGVDLSVFSTETMVRFIDIKFHFYSCSVHASCISCVASRWACDWCVFDNKCTHESSTCTEANEIILIGKNNPVSTTPKGPGSCPQLQAQSGEVLLPNGIQRSITVRTENLPDPAQISSYRCILEVEGMLQKADAEHQGSSITCEQKAYTYLANNKPELEVRLTVTWTDKTGAAHILDDVYGFNVTIYKCEVQKPDCSRCVTARPELGCLWCDSMPALSVCKLNETCTGNVVTSFNGVNCPDPVLSEVFPLAGPIEGSTVLTVIGTDIGRRFGDVMAVMVGSQPCDLDGLSSDYVIGGSVSCRTKPEREGSQSVTLTITGADGTLQHSSGVVNFKFTNPRITSFEPRLGPEAGWTAVSVYGTDLNTGRNIAAFIGEKPCIISSVPREEVLECTSSDGQAGMQSNLRISFDGANRASDEKFSYTENPVITRVQPLKSIYSGGRTLNVNGQHLDTCRNRQIYVGNSHLTYRGKCTGDSPTEMQCKSPNITSLRMMMESDENLTFGFIMDGVIELLAWSENNEVELEYFEDPVYVPFENGEMEKDGSTLTIMGERLDSAITAKEIQVRIGKDFCEVNLVSDTVLQCTLPKNEPAAGDFRGGNVEEGLPVVWVLHNNLEFVLGRLIYPRSVPVAATVAGVLVSFSVVTLLVAVLSYLRQLHRKRTHDQRLLNRIMEVHLEMSSNVKRRWWQRVQKQMDEAPTQTRIVLRNKVSYVPDELHIEFRQLELGKTLGQGAFGRVLQAVLHSEAGDQIVAVKTVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJ21</accession>
    <name>A0A8B7ZJ21_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 141-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110986901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022104885.1">
        <property type="nucleotide sequence ID" value="XM_022249193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJ21"/>
    <dbReference type="GeneID" id="110986901"/>
    <dbReference type="KEGG" id="aplc:110986901"/>
    <dbReference type="OMA" id="YPLQWNI"/>
    <dbReference type="OrthoDB" id="10056589at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3350.20">
        <property type="entry name" value="Tmem141 protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026788">
        <property type="entry name" value="Tmem141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038259">
        <property type="entry name" value="Tmem141_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47229">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47229:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15110">
        <property type="entry name" value="TMEM141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022104885.1"/>
        </source>
    </evidence>
    <sequence length="143" mass="15578" checksum="8E8F39489F196256" modified="2022-01-19" version="1">MVLVGISDLDEETAGKYPGIYQYGQCQSRAFIKGIFAFFAGGVAGLTASHVIKRRYPTIPAVYNVVFVAGGAIITSYAVASIASKQCQRMWVHTAQHNVPADAKPGSVYVQTTVPTPEPESVQCNGEDIGSFLKLYSWWKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZJF6</accession>
    <name>A0A8B7ZJF6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fos-related antigen 1-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110987047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105152.1">
        <property type="nucleotide sequence ID" value="XM_022249460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZJF6"/>
    <dbReference type="SMR" id="A0A8B7ZJF6"/>
    <dbReference type="GeneID" id="110987047"/>
    <dbReference type="KEGG" id="aplc:110987047"/>
    <dbReference type="OMA" id="AMSCGRE"/>
    <dbReference type="OrthoDB" id="10065720at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14721">
        <property type="entry name" value="bZIP_Fos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000006">
        <property type="entry name" value="fos-related antigen 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000837">
        <property type="entry name" value="AP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351:SF24">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23351">
        <property type="entry name" value="FOS TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00042">
        <property type="entry name" value="LEUZIPPRFOS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="152"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022105152.1"/>
        </source>
    </evidence>
    <sequence length="300" mass="33076" checksum="D82ABABFD6027791" modified="2022-01-19" version="1">MYPNVTLPSKEGVTNLMKNLNDVLTTMSTGAIPADGEDYTASEDIMDISSYAPPMTTSHPMSTHQSAIPTSVITPTSLTSGWLPHLNNNIHGGNFVPPSVSSSSHGSITARHQGSRAVHHGRVRSSDLELLRMSPSTSRRRIRDEDLPPEERDKRRIRRERNKLAAAKCRQRRVDHTNSLIGETEDWEEKNATLEQEISKLHQQKEQLEFILEAHKAMCRQNKANKQTATTSTATSTSSLETPTTEVVTPTSVFNYTVGTTVHNGDASDNILSCGREAIKSESSNSDMSSPEANRTLIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZK52</accession>
    <name>A0A8B7ZK52_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Baculoviral IAP repeat-containing protein 6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC110986255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022103686.1">
        <property type="nucleotide sequence ID" value="XM_022247994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110986255"/>
    <dbReference type="KEGG" id="aplc:110986255"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000001">
        <property type="entry name" value="baculoviral IAP repeat-containing protein 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="933"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1330"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="941"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1332"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_022103686.1"/>
        </source>
    </evidence>
    <sequence length="1354" mass="147307" checksum="CE5768E8D25F6F48" modified="2022-01-19" version="1">MSRSARSCRCSYPVLACGVGAGGSPNVTSLNMAAMDMAEWSLVKDGRLYLGEETSALTYHPKLNTVLAVTGGSGVRVVDVNSGVTLQNSTLSAQGDGPIHCQYLSETDQVFMTDGRAVGLRKDLSGVLLLDSALQTAVTNSEETIVIELPYLEACHLLECLKKSLKPASSQQEYVDEVQSRLESELSLVGNSVKTESHHKVTKWATIQLRVSLCALRSVCRSLLDELRRSNQHVTGLSIAAAIADRLQALYPESGRSTVGTQTVDRAQMYSEAARRETFLTWPHMNYKWALPEPMAQAGFYHQPSGAGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSPNCPFVRGEPTENVPFSFTLATGPAQLHGDGSQKITCVGTSSCPHLMVTSSRHGNVSLWDVANQLTLISNFQIDPDDPALTGKAADSEEAVDRRPRTKIPEAWVEETSLTEIKGNTKEDENANLSKCSQSVSGEDEEQDQDQAPQAAVSLHQEIAAKEKSYGTIEVIEVGGAWRNISESQPSPGIEEAAVMPEPKGNPKSSTKLIVSALGILQGLPKEPSASSSHSNAPSSDDLLSIPCLVAALSIRKPNKTDHADSIKTIPAEDCRDDQSLAAMASRGSNPFTSAFEKIRIAEDTGPIDEAGLGVDISNRKFEFADAYLGDEVDAGDVGKASETDSGSRHRKCLIIYAAPPLVKNIAVHKKSTDKSKGAFSMQAGQSTLQKMYMSQILEMEEEQQALVEEPMGIEELTADQTSSLTLVDGVHAKTFRTSEVALQCIELPACTQCDDLWVTSVASCPDKKHVLVVVGPHDGQLGNAEMVAKSQCNTLATEKVCEKQNDLNKESNCSTDEAGTGLGIDSAGSFDPSVRQVTSEAGCDPVEFGFNQASFVLIYQIKTQDGATVLQQDPVAVHRINSSDEIIKSLVPLPVDLCDVASDEEGEPSLQDPSSSEAMPNSDMGSITAELAALSLDEPDAKSPNKQLGTCALLTRSGTLRIMDISTWSILATYPTPQKHPQSTGSDRFITLTYCTGMERLCVYTESGHVLFIQLQAKKTHGVGGRGKTVKKPTPEQEVAAEEETDAPEEKQVGDEFLANQPISMKNLSILWQLTQFETLVPRFSATVPPCWVEIQQEQQQRRHPQHLHQRQQGDATQHTRTWKLQPDSSSWKEHLFELVLPKSCCVGHVDVKFSLHASCPSAPRIYLTLLKQSGTQCKKGKEKDSMNIKSPAVDAKIDFNMESSTSEPKVQNVDMDFGNPPPVPGTCRSDPEAFYGDAVTQSAYLQSHLEDILCGPCYMECFVDMPSHYGTVTLTSRQLMLCKSRSFLLHIFALDTTENEANSKTKESGKEKGMSSLLLMNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZKR1</accession>
    <name>A0A8B7ZKR1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Muscarinic acetylcholine receptor DM1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110987225</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="RefSeq" id="XP_022105470.1">
        <property type="nucleotide sequence ID" value="XM_022249778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZKR1"/>
    <dbReference type="GeneID" id="110987225"/>
    <dbReference type="KEGG" id="aplc:110987225"/>
    <dbReference type="OMA" id="IICNDRY"/>
    <dbReference type="OrthoDB" id="10071887at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001591">
        <property type="term" value="F:dopamine neurotransmitter receptor activity, coupled via Gi/Go"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF125">
        <property type="entry name" value="DOPAMINE D2-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="54"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022105470.1"/>
        </source>
    </evidence>
    <sequence length="453" mass="50276" checksum="CFD7071254C6D923" modified="2022-01-19" version="1">MSLHHVLGHHGMGDMAMVNGSDHRMEDYFPQSETISSWILLVVCGVLMCITVPSNLLVLSAFSTEKKLRTYGNLFIINLCVADLCIGAINMPLTVLEESMKLMGRAWPFGHIFCHLIKTLEHVFLSASIMTVLIICNDRYQAIRHPLSHLQDRSTRRAGLKILLTWGVAILVWLSFILVWGVVEGDDALPHMFCTAMYNTNHYSTGVAIALAMWIPYPAILIMYCRVYRTIHAVRKGKLKKSTMTMKAKNDTSSHEDDATTDFTAFGIGNSREEIPTISVMTVELKFCQQNSAALGQQVCNHRAAGTSLTGSKLSRNLKTEDRGEPPETAPPTVSTSLDRAESSPVPNENINLRRYRKNKADNKKATLTLSLVVASYAICWLPYGIIVPITSICDMHPGAFPPLPAYYNAAVVAFSMCQSAVNPFCYAVAQPAIRHAVFKILSCYHCCFKPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP18</accession>
    <name>A0A8B7ZP18_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Acid-sensing ion channel 1C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110987842</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022106645.1">
        <property type="nucleotide sequence ID" value="XM_022250953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP18"/>
    <dbReference type="GeneID" id="110987842"/>
    <dbReference type="KEGG" id="aplc:110987842"/>
    <dbReference type="OMA" id="CEMINIM"/>
    <dbReference type="OrthoDB" id="6021021at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF300">
        <property type="entry name" value="PICKPOCKET PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="3 11" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="9 11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022106645.1"/>
        </source>
    </evidence>
    <sequence length="505" mass="56546" checksum="95F8CC96476F30A1" modified="2022-01-19" version="1">MGIRVKPIEDDISIISFNTDEVKIDKRERDKETTGDSLKTGRAGPQKGSKYHSSRCTKFLATWSSTLPDAVGITGIQYIVSNQDHILRRFVWLLALFGGFAAASYQTIDRTIYFLSNPKSVDYEIKYISPLEFPAVTVCNYNSYRNAALFSNVTYHPFAFLLSEVSNAIHTQQPVNYSYYETYLTDVNTTEMYLQLAHEMEYSQMLIVAYWDGWGSVTSANFTRVITDFGVCYTFNAGQAGQELLKQKVAGKGHGLSLMLDAQQYFYFYSSKALQVSAGFVVAIHNQSEVPQVDSLGVGVAPGTEVRIGLKRKEAINLEPPHGECGSKELKYFSSYSINSCRQECLTDFVLEGCGCVEPYMAVPSDLPVCNPAKVFSCVYTETERFNSDGVCECPIPCQQTTYTTSLSFATFPSDFYIQTLVNLYSDFNVTPEYFSSNTLKIEIYYEELSVESMEQQEAYTFFALLCDLGGALGLWLGGSILTFVEILDHFGHTAFLRGTAFQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP36</accession>
    <name>A0A8B7ZP36_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7 8 9">Protein NLRC5-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8 9" type="primary">LOC110987957</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8 9" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106821.1">
        <property type="nucleotide sequence ID" value="XM_022251129.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106822.1">
        <property type="nucleotide sequence ID" value="XM_022251130.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022106823.1">
        <property type="nucleotide sequence ID" value="XM_022251131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP36"/>
    <dbReference type="GeneID" id="110987957"/>
    <dbReference type="KEGG" id="aplc:110987957"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000488">
        <property type="entry name" value="Death_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00531">
        <property type="entry name" value="Death"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00005">
        <property type="entry name" value="DEATH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50017">
        <property type="entry name" value="DEATH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Death" evidence="4">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="296"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022106821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022106822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022106823.1"/>
        </source>
    </evidence>
    <sequence length="1277" mass="142208" checksum="3A6699C58ED500DC" modified="2022-01-19" version="1">MADWDGGESQRRLGRHHEATGPLDDDSLYSISTQIHAGEWRGLATRLGFSAAEVSHFPSDHSFTAEQINQMLVTWRNRQPVHVNQTEALCKALKEVGNAQLADNLTENQPSACKQPTTQRAVLCSQTPGELDDSSLYDIAEQIDANEWTRLAAKLGFNQARVSHFKDNHSSVVDQINGMLVAWRKKQPGDVNQREALCKALREVGDINLADKLSEYSASDVQSLNAANICEDELKSHYKETGSFLQMNPWCEDLKKPIAEMCTKVQLITGEGKTEYTLVSYEEMLLLKTKEGKLIPIAVLSGLAGRGKTTLFDKIAYDWAAGSCKVLQKYKLVFLLKMCNLKQESNLVGSVFDQLLAEDTNLDLNALESYIKMNSGKVLILLDGFDELRTTSLNKSSFGSILKILNRRMCRGCTVLVSTRPSHLVRLTTKALIQQPFTHVRVMGFSKEDITEYVNKFYCDEPTKAKELLTRIRSSNLFSVLAESPMLLLMMCSLWSKDSKLPETMSSFYHNAVDEIGKRKDVSEQEINSVVIELGKVGLQGLLFPDQVLSFKDSDFEPGELNLALKAGILTTQRVFKGRVPHGSVQFIHKTFQEFCSALYLQNLFEVNRQEFQKILNEIVSKSPVDFEYLLRFCCGGNETCTFEILNVFLAKCKNRLSVRDRVGQLALHCYFESQCKCLPSKKFIQAVLRDNINLHGLLDDTLLSVTYFLRRVAEDSGSAYLDKIKKLNISHCEWIRSVTDLAFAVSAMKSLNKAQIIGSLTSETIAPVMKSLRNLAKLVSLNLFYNYLDSTAASWGMHLKEIKPLQWLNLSHCSLNGEDMVHVAESLKDLPNLARLDVPNNNLGGTAASWGIHLKELKPLQELILRNCSLNGQDMVHVVESLKGLHNLATLDIPGNNLGGTAASWGIHVKELKPLQRLDLRNCSLNGQDMVHVVESLKDLPNFAELDVSDNNLDGTTASWGMHLKELKPLQEVDLSHCSLNEQDMVHVVGALKDLPNLARLDVSGNNLGGTAASWGMHLKDLKPLQKMDLRGCSLNGQDMVHVVELLKDLPNFARLDVSDNNLGGSAASWGMHLKELKPLQRMDLSHCSLNEQDMVHVAESLKDLPNLARLDVPYNNLGGTAASWGMNLKDLKPLQRMDLRGCSLNGQDMVHVAEALRDLPNLVSLDVHSNNLGGTAASWGMYLKELKPLQELDLRSCSLNGQDMVHVTKSLKELPNLVSLDVSGNADLAGTATSWCLPLKHAKALRDPELYSCELTEEDKKRLHDALGNLDKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZP75</accession>
    <name>A0A8B7ZP75_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110987081</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Lipid-anchor</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AB hydrolase superfamily. ABHD17 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022105196.1">
        <property type="nucleotide sequence ID" value="XM_022249504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZP75"/>
    <dbReference type="GeneID" id="110987081"/>
    <dbReference type="KEGG" id="aplc:110987081"/>
    <dbReference type="OMA" id="TGQASEC"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000008">
        <property type="entry name" value="Alpha/beta hydrolase domain-containing protein 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="11">
        <location>
            <begin position="89"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022105196.1"/>
        </source>
    </evidence>
    <sequence length="291" mass="32457" checksum="8CEF2572C4AA370A" modified="2022-01-19" version="1">MNGLTVGELCCLFCCPPCPSRIAAKLAFLPPEPTYTIVTDETGTKGTLNLTERAEWQYSDRELESIEVFYTRNKRGNRTACMFVRCAPNPKYTLLFSHGNAVDIGQMSSFYIGLGSRINCNIFSYDYSGYGASGGKPLERNLYSDIDAAWQALRSRYGISPESIILYGQSIGTVPTIDLAARYECAAVILHSPLMSGMRVALPETKKTWWFDAFPSIDKVSKVSSPVLVIHGTEDEVIDFSHGLAIYERCPRTVEPLWVEGAGHNDVELYGQYLERLKQFITQELPNMSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQK6</accession>
    <name>A0A8B7ZQK6_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC110988179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable oxidoreductase that may play a role as regulator of mitochondrial function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with COX5B; this interaction may contribute to localize PYROXD2 to the inner face of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107165.1">
        <property type="nucleotide sequence ID" value="XM_022251473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQK6"/>
    <dbReference type="GeneID" id="110988179"/>
    <dbReference type="KEGG" id="aplc:110988179"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10668">
        <property type="entry name" value="PHYTOENE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10668:SF103">
        <property type="entry name" value="PYRIDINE NUCLEOTIDE-DISULFIDE OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="6">
        <location>
            <begin position="273"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="RefSeq" id="XP_022107165.1"/>
        </source>
    </evidence>
    <sequence length="630" mass="69177" checksum="2C1016054F6C21C6" modified="2022-01-19" version="1">MMLNAVRAAFSQRMHVKPLISCSYHVTARRFSKSHARQGDPLAQEYDAVIIGAGHNGLTAAAYLQKAGLKTLVLERRHVTGGAAVTEEIVPGFKFSRCSYVLSLLRPDIYEDLELKRHGLKVHIRDSYAFTPLLEDPGPGGRPRSLLLSCDQNKTYEQIAQFSEKDAKRYFEYEHEMTAIAQALGPLIDAPPVELSAISNGTLRDRMDIWPGVKAILQTGKALGKNLPQFYELVTAPMEKILDRWFESEPLKATLATDSVIGAMVTPKTPGSGYVLIHHVMGEAEGIKGAWGYAEGGMGAVSRSIANAAEAHGATILTEKPVSTVLLDSDQRACGVVLEDGTEVRSKIVLSNATARITYLNLTPEEALPKEFIEEVQAIDYTSPVTKINVAMDRLPDFKASPSGKTKQPGPHHTCTIHLNCETTDLLEKAYQPCQTGHISDRPMIEMCIPSSLDQTIAPEGCHVLSLFTQYTPYHLADGKKWDEDAKNAYADKVFDCIEDYCSGFKSSVIGRDILPPPELERIFGLTGGNVFHSTMSLDQIYFARPVLSSTYRSPLPGLYLCGAGAHPGNLIHSNGELRAGLLYFSLFLCSKWICHCFFTLLIEHFSWCNVSGPALFCPACDVLKLQVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQU1</accession>
    <name>A0A8B7ZQU1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HCLS1-binding protein 3-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110987400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022105806.1">
        <property type="nucleotide sequence ID" value="XM_022250114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQU1"/>
    <dbReference type="GeneID" id="110987400"/>
    <dbReference type="KEGG" id="aplc:110987400"/>
    <dbReference type="OMA" id="NRIQTMN"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039701">
        <property type="entry name" value="HS1BP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14431">
        <property type="entry name" value="HCLS1-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14431:SF1">
        <property type="entry name" value="HCLS1-BINDING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="16"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022105806.1"/>
        </source>
    </evidence>
    <sequence length="394" mass="43641" checksum="08CBE6A0258EDAE5" modified="2022-01-19" version="1">MTSPIGTSREIKNKETGLDIFVPEYREVSGMLMSHEEYHVIVITNLPYFKTIKNKMDNNVQFMVVKRYGDFEALHKTLSERFPATIFPDLPRKVLLVKDSTPQQRRQCFDNLMRFIASNKKVCCSNPVLTFLGVKPEMIQKVEGEDEEKDSKEETTDGKELPQGLPKRRSKLLSSGSQQSSLFSDEPEDEFDFFQEDPNTTETNSEDIENGLFTANSFTTSSSKAKKDTGVLLFSDNIEDMTDMDNAGGIYLPLGAEDTHKKTSEFLGLDDEDDKDLLNIEDDLDQLLSDVIKKPERPAKKPSPKSKPSPANKSSLSAGKPTLAQRPVPAARATGPGKTPPKPAPRRGKTTSTGGTQAAGTQSEGQNVETMDDGDILKYIQENAADEAASLDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZQY4</accession>
    <name>A0A8B7ZQY4_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transmembrane protein 26-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022107477.1">
        <property type="nucleotide sequence ID" value="XM_022251785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZQY4"/>
    <dbReference type="GeneID" id="110988365"/>
    <dbReference type="KEGG" id="aplc:110988365"/>
    <dbReference type="OMA" id="QFDLYNT"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022107477.1"/>
        </source>
    </evidence>
    <sequence length="338" mass="38026" checksum="CE5456DB79046A84" modified="2022-01-19" version="1">MGVVSFLKALLARCLFAIHGIITIWRVTEVNSEMIYYLLVIPVCLLPFEMIITLKFTENGEWKWFCPSVLLYLASVVPGLWLLQFDLYETRIEYRDFMGWTDCSSETVYNSSGLSSNVAGLQVSIPVSLSDDAWALSLEQFLLALLIMGRWLLPKGSLTRDQLSQLLLVYIGMAADILEFSLESLKEQVVICNLLLIIIILGLWSWSLLQFTLVLTSVSAPRTRAARTTGGRSCKGCCRCCENEIWALCTTILMQDGPFLVMRLFLLINYSVINQMMLFFTIKNILVILLQVYRMTIVCCDGPSTVEPDVEAMEAVEEGDISNDQQNSSQKTLTEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZSD9</accession>
    <name>A0A8B7ZSD9_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110988590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with LYAR and RPL23A. Interacts with the nuclear importin-beta receptor and, at a lower extent, with importin-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107967.1">
        <property type="nucleotide sequence ID" value="XM_022252275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZSD9"/>
    <dbReference type="GeneID" id="110988590"/>
    <dbReference type="KEGG" id="aplc:110988590"/>
    <dbReference type="OMA" id="EVREWIF"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="273"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="605"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="721"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="750"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022107967.1"/>
        </source>
    </evidence>
    <sequence length="839" mass="94815" checksum="BDF5212620E4F0A6" modified="2022-01-19" version="1">MGLDHREPLKIMHETHSQCTCVHVRVLQSFVVVYKLSYHNWPSPKLELSTDAEQSLVFNLSPTLNMAKTIKKQKRKDKISKSASSSNPDRLKGAGGHNMRDRTTIKRLKMYKGGKPTRNAAGKIIKSAVFQSRLPSGSVARVEPNRRWFGNTRVITQSALQTFQEEMGKVLKDPYRVVMRQTKLPITLLQEKSKNSRVHILDTESFETTFGPKKQRKRPNLKVSDLQDLLKTVEDSAEKYDEEKDKDLVTDNEGVRPEVREWIFGAGQSKRIWNELYKVIDSSDIVVQVLDARDPMGTRSKFVETYLKKEKPHKHLVFVMNKVDLVPTWVTKRWVALLSAEYPTLAFHASVKNPFGKGALIQLLRQFGKLHIDKKQISVGFIGYPNVGKSSIINTLRAKKVCKVAPVPGETKVWQYITLMKRIFLIDCPGVVYPTGDTDAEIVLKGVVRVERLETPEDYIPALLDRVKLDYITKTYRVTDWTDPNDFLEKVAQRTGKLLKGGEPDVRTVAKMVLNDWQRGKVPFFVKPPNCELDPENEKEGVSDKTKMTVPSDEYKSVGPPETSQSEVTITSSVDKNTASEKSQATKCVSSVHQDFSGISIGVDFASDDLQPDENRRGSSPVSTSGEDVESPLVASTGEVDTERSQTDPVAEDVTEIVPDKDRKRPKSKTQKLKAPSMEKMIAKYKSSAPNSEPANIGVTAFGVNAFLSRDNQKMLASIQAARKLKESSKEEGNSATKTSKKKPVGRSFLKLDKVEDTEDDKRGQMRKRYFETVDDEDDGRKAKQSKGFTAKERRRNERKAQSKKTGQHYYATANVKNKNRNRSRDPNARPRKGIKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTJ6</accession>
    <name>A0A8B7ZTJ6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110988999 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110988999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108744.1">
        <property type="nucleotide sequence ID" value="XM_022253052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZTJ6"/>
    <dbReference type="GeneID" id="110988999"/>
    <dbReference type="KEGG" id="aplc:110988999"/>
    <dbReference type="OrthoDB" id="10417677at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022108744.1"/>
        </source>
    </evidence>
    <sequence length="188" mass="21034" checksum="D2E5D79501AD5D66" modified="2022-01-19" version="1">MLKKLQLSSPLEKDVKKKDVNCLLYFFCQSVSKCQLFRKLLWFEIAGDNQSLETVEGISSTMTITSVIVGTVVTQVVGAFWYNVFAEPWMRGLGKKREDFKNTDSSPFLLAFLAMFALSAFMSATLRPFFGVVTVEEAIHFALRVSVAGALLQIPHRSFQGTGWSTYFVNVGYDAVCLLIICVITTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZTX1</accession>
    <name>A0A8B7ZTX1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LOW QUALITY PROTEIN: uncharacterized protein LOC110988018</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110988018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022106936.1">
        <property type="nucleotide sequence ID" value="XM_022251244.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110988018"/>
    <dbReference type="KEGG" id="aplc:110988018"/>
    <dbReference type="OMA" id="THAFEDD"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF18">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="34"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022106936.1"/>
        </source>
    </evidence>
    <sequence length="161" mass="18253" checksum="3FC946C234627763" modified="2022-01-19" version="1">MKDEWHIEYAPYSRINKKISKIVRFIIYQLSSSPTIGIIGLPNVGKSLLFSLITKKKIEIANYPFSTIEPNIGIVPLPDQRLSKLANFYQTKKIVAPLIKFXDIAGLIKGSHLGEGMGNLFLSHIREATALVHVVRFKNAGLFRKEGQKYQVKDGDIFKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZUE1</accession>
    <name>A0A8B7ZUE1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein LOC110988158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC110988158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022107116.1">
        <property type="nucleotide sequence ID" value="XM_022251424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZUE1"/>
    <dbReference type="GeneID" id="110988158"/>
    <dbReference type="KEGG" id="aplc:110988158"/>
    <dbReference type="OMA" id="PVIANMS"/>
    <dbReference type="OrthoDB" id="9991628at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07066">
        <property type="entry name" value="CRD_FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF47">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034649145" evidence="6">
        <location>
            <begin position="30"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="7">
        <location>
            <begin position="32"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_022107116.1"/>
        </source>
    </evidence>
    <sequence length="503" mass="53782" checksum="33D7370110805562" modified="2022-01-19" version="1">MSMMRIVRSEVAFLVVGVILSECATLAIGTTCEEIPVDICSALPYTQTGFPSSLGHASRDQIPPNLGSAFQTLIAIGCYENVQLFLCAAAFPQCSTSGPLLRPCRALCEGAMLGCGFWFGFYSDLLDGINCEAMVNSSDPNICVGLNTTPQLHVTSQQVPKGNTAIFETTLQMKTTNSTGLANTHNSVSTSETLFATLLPRQPATTLSRENEDDENEADVHRKPVNSTFFYLASSDFTSEVTGQRSTASKGGHKMTDSVDKAVKTDTNIQGGFKSPSIHVVPALGVLLSALSCAGMVVLLVSCAFFRKAFGKPFGVRRRKPRDGAFYTNPAFSDLPQASEVRSENGQSLQSKQQPYTLDDLPPHPASANAMLHPHKQVDPNIYQLEPNGFVEQNLFAVPHSPLHNHPDTTDPLKASAASSKVETKVSSDMEDSGRVTSDLVYSNKVPSVAMDSNENKHGPNTSRREGNNGSAAAPSSGDSFPVTSTSCNMDNGEMVIANPIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZV72</accession>
    <name>A0A8B7ZV72_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Low density lipoprotein receptor adapter protein 1-B-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110989142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022108987.1">
        <property type="nucleotide sequence ID" value="XM_022253295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZV72"/>
    <dbReference type="GeneID" id="110989142"/>
    <dbReference type="KEGG" id="aplc:110989142"/>
    <dbReference type="CTD" id="26119"/>
    <dbReference type="OMA" id="FPKVFAF"/>
    <dbReference type="OrthoDB" id="9999955at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd13159">
        <property type="entry name" value="PTB_LDLRAP-mammal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051133">
        <property type="entry name" value="Adapter_Engulfment-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006020">
        <property type="entry name" value="PTB/PI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232">
        <property type="entry name" value="PHOSPHOTYROSINE INTERACTION DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11232:SF74">
        <property type="entry name" value="PTB DOMAIN-CONTAINING ADAPTER PROTEIN CED-6-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14719">
        <property type="entry name" value="PID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00462">
        <property type="entry name" value="PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01179">
        <property type="entry name" value="PID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PID" evidence="2">
        <location>
            <begin position="28"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022108987.1"/>
        </source>
    </evidence>
    <sequence length="361" mass="40231" checksum="06E04DCEF51B9F54" modified="2022-01-19" version="1">MMKNRFGKGRHRKFQDDWERSKEPVLEGVTFYAKYLGMCLVSLSNDETHTAEAVKRIIHNAKYHSKLLFKKVSLTVTPKAIIQTNLERPEDVQEVSIHRISYCAADKTSDNKVFAFIANNSITEALECHAYLCSKRKIAEALTLTVAQAFNIAFELWEREKEEQDIVSDDSKDAPPSSPLQKSAPQSIPSSKSTSSSNGRDEACWSSGASPALPPSLDPPPSSTRKVLKVQAEMDPISASAPCTVPVVPPRRPTGMPRFSPCMVNGNGQHDSGIDSSLDSKEMDATAKLLENWHIGEDVDLDESFSKLAECRSNPQLLDINVRRTQFDADIIVHFQGNKTERDQLLESRSSENFQFDLQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZW16</accession>
    <name>A0A8B7ZW16_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein LOC110989562</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC110989562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022109743.1">
        <property type="nucleotide sequence ID" value="XM_022254051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZW16"/>
    <dbReference type="GeneID" id="110989562"/>
    <dbReference type="KEGG" id="aplc:110989562"/>
    <dbReference type="OMA" id="IRFHRIC"/>
    <dbReference type="OrthoDB" id="10047121at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="CDD" id="cd00304">
        <property type="entry name" value="RT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301:SF11">
        <property type="entry name" value="GIY-YIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21301">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="RefSeq" id="XP_022109743.1"/>
        </source>
    </evidence>
    <sequence length="420" mass="47068" checksum="A80A8103AC4ECBCD" modified="2022-01-19" version="1">MHIISCDQLPRCAEESSARRTTQRPIESAVDTSKWVVNLSARTLTTVETSLLGKGLNFAVTPDHVPAMEIVSSVETTLKRLDSETADLVRREVNATLRRARPPRSNINREQRIALKVLRQDRSIVILPADKGRASVILDAHMYRDKMGELISTGPYWKLAKDPTDRLCRQITAQLLPLNKSGNLDDATYRKLRPTSKQPPRMYGLPKIHKPGTPLRPIVSCVSSFAYNLSKHLAGILSPLTGNTPNTYPTPQLSLTDGACCVALHHLEEDPELPDRTSLSPAEVVSLVEFVLRSTYFLYDRAYYEQTDGAAMGSPVSAVIANLYMKSFKEEALQSCPPDCRPTLWKRYVDYTFVIAPRDQASRLLNHLNSLKPRIKFTIENEQDNSIAFLDTMIHREADGSLTSTVYCKPTHARPLTPME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZXB8</accession>
    <name>A0A8B7ZXB8_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="5 15">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC110989840</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="5 15"/>
    <dbReference type="RefSeq" id="XP_022110193.1">
        <property type="nucleotide sequence ID" value="XM_022254501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZXB8"/>
    <dbReference type="GeneID" id="110989840"/>
    <dbReference type="KEGG" id="aplc:110989840"/>
    <dbReference type="CTD" id="5226"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="7 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 15" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="17">
        <location>
            <begin position="224"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="55"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <begin position="231"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="13">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="497"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="RefSeq" id="XP_022110193.1"/>
        </source>
    </evidence>
    <sequence length="527" mass="57752" checksum="0B5BFF39778225FC" modified="2022-01-19" version="1">MGKGTMGSCHGKDIQVKRPPHEQPRDEKGNGKLPIDQRPKQMEYGGERADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVTEFLNNEAKGTKVVGAMSMEEMVGKLKKPRRVMMLVKAGAAVDAFIDKLVPLLEKGDIIIDGGNSEYVDSNRRCKALAEKGLLFVGSGVSGGEDGARYGPSLMPGGAEEAWPHIKSIFQSIAAKVGDEPCCDWVGSEGAGHYVKMVHNGIEYGDMQLICEAYHLMKDLLGMSCDEMSEVFSEWNKSELDSFLIEISADILKFKDTDGQPLVEKIRDSAGQKGTGKWTAISALDQGMPVTLIGEAVFARCLSSIKDLRIEASKVLPGPGSSKYEGDKKEMVEHIRQALYASKIVSYAQGFMLLREAAKQYKWTLNYGSIALMWRGGCIIRSRFLGNIKEAFDKNKELSNLLLDDFFRGEIIKCQDSWRKVVAQGALNGIATPAFSSALAFFDGFRSERTPANLIQAQRDYFGAHTYELLSAPGKFVHTNWTGHGGNVSSSTYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ZYY6</accession>
    <name>A0A8B7ZYY6_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Matrix metalloproteinase-14-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC110990105</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022110634.1">
        <property type="nucleotide sequence ID" value="XM_022254942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ZYY6"/>
    <dbReference type="GeneID" id="110990105"/>
    <dbReference type="KEGG" id="aplc:110990105"/>
    <dbReference type="OMA" id="DAEQWTI"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000068">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF294">
        <property type="entry name" value="MATRIX METALLOPROTEINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034982221" evidence="18">
        <location>
            <begin position="28"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="19">
        <location>
            <begin position="113"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="336"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="17">
        <location>
            <begin position="383"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="16">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="14">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="15">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_022110634.1"/>
        </source>
    </evidence>
    <sequence length="513" mass="56600" checksum="099D71DB72B6BDB4" modified="2022-01-19" version="1">MERAEVSTGKTLFMSVLLVAAVTVVHSSVETGVDAMMYLTYYGYLRPMTSDDGTFMTEEEMREGISKFQYMANITQTGELDNDTMRMMNMPRCGMPDVVGHSLDAKRKRRYSLGSRWSKTDLTFRIDSVTSDIPSRSDIDDTLEAALQVWADVTPLTFTRVSGNTPADIVINFNSGVHGDGAPFDGPGGVLAHAFFPEDGRAHFDEDETWTINSFSGINLFQVAAHEFGHNLGLGHSNIDAALMAPFYRGYVPNFQLHEDDIAGIQAQYGSDSGAPVVTMEPSAEVCTGIVDAVTTSRDRSTYLFEGTQVWKFESGASRIADGFPRAIGSVFSGLPDNVDAALFYQPNGKTYIFKGSQYWRFDNEVLDSGYPKSIATYWPGLPNDLDAAFVWSGNGRLYFVKGGQYYRFGSGRVDTGYPRPLSVWNIPGNQVGAAVQWINSRTYFFNSDGVYYRFNDRYFRVDTGYPRNVASTWQGCDTNIVEKPEPGDNGAGGLAPGLLASMATVFFAYVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B8A6D1</accession>
    <name>A0A8B8A6D1_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Follistatin-related protein 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC110990753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022111541.1">
        <property type="nucleotide sequence ID" value="XM_022255849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B8A6D1"/>
    <dbReference type="GeneID" id="110990753"/>
    <dbReference type="KEGG" id="aplc:110990753"/>
    <dbReference type="OMA" id="RYLPVCG"/>
    <dbReference type="OrthoDB" id="6085115at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231">
        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12231:SF253">
        <property type="entry name" value="DPR-INTERACTING PROTEIN ETA, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="RefSeq" id="XP_022111541.1"/>
        </source>
    </evidence>
    <sequence length="525" mass="58251" checksum="A3E2F1FE03091407" modified="2022-01-19" version="1">MHMGTYTCYVEGYKSVQQTYTVEVQVPPSVHTCPNFRLQSLGKTAKVQCYAQGVPEPDKCWSQRGVTITERPGLTIEDGNTTVHVESLDYPDTGKYLCRASNPVGTVQAVSSVFIQENTKALDFGPVHVFYLFHSHGIRILEPDSCGFRLNIPPKHVLPKPHGLLCPPSPTGEIACSWGQAINVLNQFLYVTQPNNNRIIVVDIRTQLIIEVIQTDRVPFSLHYIPHLDTVWVVCWQSTDPNGGQRSVQVIKYVSHREMHTPIHTTPIGHHFDVVKGLYIPQVQIPNQGNYKFGYVVHSQQMAITKINLETTTLSSTIVLSQHQCYPDSVAFLSIGGYVIVSCADGGESQPSRQLFLDYLTDTVLHTNEGIQGTPYISPDGRYIISADNQHGLIYVQKVTLSGKVKSLFEVSTNLGVSDVGFFPTKASTHAYDIMVTSSDRPDVLFVDLQTSKVKMIPGVFDPINPDSWPWNEHNRHIVSSGVFGSHLATPSADHVVLIDGKKKSVHCNVDVSQSNVIVWVGDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGW8</accession>
    <name>A0A8B7XGW8_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 4-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110973481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAPGEF2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022080029.1">
        <property type="nucleotide sequence ID" value="XM_022224337.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110973481"/>
    <dbReference type="KEGG" id="aplc:110973481"/>
    <dbReference type="CTD" id="11069"/>
    <dbReference type="OMA" id="CVRLCCV"/>
    <dbReference type="OrthoDB" id="21144at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04437">
        <property type="entry name" value="DEP_Epac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000002">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000015">
        <property type="entry name" value="Rap guanine nucleotide exchange factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF327">
        <property type="entry name" value="EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="6">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="7">
        <location>
            <begin position="236"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="6">
        <location>
            <begin position="378"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="517"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="8">
        <location>
            <begin position="705"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="5">
        <location>
            <begin position="809"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022080029.1"/>
        </source>
    </evidence>
    <sequence length="1048" mass="119942" checksum="A8DBBA17C7503429" modified="2022-01-19" version="1">MTMVAEWISCLDKRPSDRTGEDLDIIYSRLKDVKAFEKIHPLLLQEICCYGYYEDLEKGITLFRQGDIGTNWYAVLSGTLDVNVSDREIGNTKEAVTICTLGIGTAFGESVLNDSPRHATVITSEFCELLRVEQKDFKMIWERNRQLMEGILAPNPLSVPSIVSTAAASQPNQSITNRGIGSHHQLYSRSGSMSGPDSSKRTHEGAAPIHPALPIVKTPSERLSRAGFVLRTILLTRSPQMIRDRKYHLRTYRRCLVGSEMVDWLIQQSPMTLVHSRQQAVGMWQALLEEGVITHVCREHPFKDKYLFYRFRDDDMGIGSQPGNAEKKEAEDEFQDTLVILAQIGPDAMMRMILRKPAMERSVDDLEIIYEELLHIKALAHLSTMVKRELASVLVFETHQKAGTVLFNQGDEGKSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDSPRAASIVLREDNCHLLRVDKDDFNRCFXDVEANTVRLKEHGQDVLVLEKIPTNSGQRQDGAPIHYKYSVMAGTPEKMLEHILETRIDSKQDETDTFLEDFLLTHIVFMSSKQLCPALLTHYHADIVQATEQETIDYIVNNKRRVIRLVCQWSVIAGSAFQEDPVITSFVETLFSAICDDCRIYSSLQDELANLERVFHLVRKMEEEQAHTWQVQRQSIMGYPGTELFSIAKGLGEFHRSEDDTPRRRPIKATDENIFKVYCADHTYTTLRVPMNTTAGAIVRSVSEKMCLGEDLVLCEIKSTAERILFKENDICVTAGLSLNGRIFVSPREHLDALTPIPEQEGPSDSTFAMFELMGSKEVAYQMTLYDWELFNCVHEFEFVYHTFGRQKFGQITANLDLFLRRFNEVQFWVVTELSLTNNVSKRVQLLRKFIKIAAYCKEYQNMNSFFAIVMGMSNIAVCRLTQTWEKLPSRFKKTYAEFEATMDPSRNHRVYRLSVSQMQPPMIPFMPLAIKDMAFTHEGNKTYFDGLVNFEKMHMIASTIRTIKYCRSEPFTMDPPPPVKNISEIRNYVRNLRVIDNQRVLTQHSHKLEPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHH4</accession>
    <name>A0A8B7XHH4_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110973214</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022079557.1">
        <property type="nucleotide sequence ID" value="XM_022223865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XHH4"/>
    <dbReference type="GeneID" id="110973214"/>
    <dbReference type="KEGG" id="aplc:110973214"/>
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        <property type="component" value="Unplaced"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015375">
        <property type="term" value="F:glycine:sodium symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
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        <property type="entry name" value="SNS_sf"/>
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    <dbReference type="PANTHER" id="PTHR11616:SF240">
        <property type="entry name" value="BLOATED TUBULES, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NANEUSMPORT"/>
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    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
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    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="73"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="106"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="256"/>
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            <begin position="303"/>
            <end position="320"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="332"/>
            <end position="357"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="490"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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        <location>
            <position position="64"/>
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        <location>
            <position position="68"/>
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        <ligand>
            <name>Na(+)</name>
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        <location>
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            <name>Na(+)</name>
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        <location>
            <position position="338"/>
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        <ligand>
            <name>Na(+)</name>
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            <label>1</label>
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        <location>
            <position position="403"/>
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        <ligand>
            <name>Na(+)</name>
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        <location>
            <position position="407"/>
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        <ligand>
            <name>Na(+)</name>
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            <label>1</label>
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            <begin position="166"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="PIRSR" id="PIRSR600175-1"/>
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            <dbReference type="PIRSR" id="PIRSR600175-2"/>
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            <dbReference type="RuleBase" id="RU003732"/>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_022079557.1"/>
        </source>
    </evidence>
    <sequence length="629" mass="70573" checksum="3EC04DC6DF568D9D" modified="2022-01-19" version="1">MTEIQSGTVATSGPPEGGKYMMQVNDGDPKSETKPSPEKGDENETRGNWTGKLDFLLSCVSFAVGLGNIWRFPFLCYENGGGAFLIPYVLMIFMAGLPLFFLELSFGQFASQGCLSIWSISPLFKGLGFGMLILCGLVTLYYNIIIAYTLFYLFASFTSDVPWRSCGHPWNSENCTVFSKDDNRTWNGTFDNGTGYARPSEEYFNNYVLDISDGIHIMGPVKWDLALCLLLAWILVFLSLVKGIKTSGKVVYVTSIFPYVVLTCLLIRGITLEGAIDGIIYYIKPDIEKLKQAKVWQDAAVQIFYSLGTAFGSLHTLASYNKFHNNCFRDAIAVTFINCGTSIFAGFVIFSVIGFMAHDAGMAVDKVVESGPGLAFIAYPEAIARMPLSTLWALLFFLMVFMLGLGSEFCMFETVITGMVDELEKFNPVFRKRKWLVTLLMAVLMYILGLSMVTNGGIYLLTIMNSFSAGLSVLIIAMLECIVIAYIYGADRFLDDLNVMLGFRPGIYWKACWKLLSPAFLMFIIVFTFVGYSRMKYNTYTYPVWAECLGWLMTLASLVPVFVYPIYYLLKQEGTFMERLRESLRPTSEWGPALEYHRKEAGFPILPEESQVTPPDEVKKLFKEAESNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XHY2</accession>
    <name>A0A8B7XHY2_ACAPL</name>
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        <submittedName>
            <fullName evidence="4">Corepressor interacting with RBPJ 1-like</fullName>
        </submittedName>
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        <name evidence="4" type="primary">LOC110973329</name>
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        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Eleutherozoa</taxon>
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            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="nucleotide sequence ID" value="XM_022224035.1"/>
    </dbReference>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:transcription corepressor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CIR1"/>
    </dbReference>
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        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151">
        <property type="entry name" value="CBF1 INTERACTING COREPRESSOR CIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13151:SF2">
        <property type="entry name" value="COREPRESSOR INTERACTING WITH RBPJ 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
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            <begin position="183"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
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        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
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            <begin position="225"/>
            <end position="240"/>
        </location>
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            <begin position="252"/>
            <end position="263"/>
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        <location>
            <begin position="283"/>
            <end position="293"/>
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            <begin position="396"/>
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    </feature>
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            <dbReference type="Proteomes" id="UP000694845"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022079727.1"/>
        </source>
    </evidence>
    <sequence length="456" mass="52987" checksum="95EEE573A157702B" modified="2022-01-19" version="1">MGKSFANFMCKKFFHPSSFANIKRVWLAEQRVKEETKKQDDLREEYEKDQDHYNNRQLMGDERVKHGLTFIYEAPKAYQKEADKETDGKLVWKRAATAQGSSSTAVGSSAGDGVVVRNVRCVKCNQMGHIPTDRECPLYKTTEEKPDGRPVHQDQLVEDMRRDGYAFKQSVLGRSIDDANYSKDLIGDDDSDDGPPPEEAFLNSLTKKQKKKLLKKLDRMEKKHSGSVHKKKNRHKRQRRSGSGSSEDEPGKHHREKKKRKRPRESSDDTTSSSEESSDGGHHQGKKSRRRCQSGRGDRDGPGGNRRDSSSGDERGSKVCNDRKLHPSDRHRGHGHKKERTSRDPGRSQNGHGQQQNDSSDDDRRTGSKPARQHRDRDSHDRHLSEHIRDKHYHKSSWEDRDSKDRDTSRIKNEKDRRDDRRDDRRDDRRDRGPSERHSKDYSDRKEDRYSKKDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIE0</accession>
    <name>A0A8B7XIE0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydropteridine reductase</fullName>
            <ecNumber evidence="7">1.5.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HDHPR</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Quinoid dihydropteridine reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC110973780</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of quinonoid dihydrobiopterin into tetrahydrobiopterin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17869"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:17871"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28889"/>
            <dbReference type="ChEBI" id="CHEBI:30156"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.34"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:17867"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.34" evidence="7"/>
    <dbReference type="RefSeq" id="XP_022080564.1">
        <property type="nucleotide sequence ID" value="XM_022224872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIE0"/>
    <dbReference type="GeneID" id="110973780"/>
    <dbReference type="KEGG" id="aplc:110973780"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004155">
        <property type="term" value="F:6,7-dihydropteridine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070404">
        <property type="term" value="F:NADH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05334">
        <property type="entry name" value="DHPR_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000157">
        <property type="entry name" value="Quinoid dihydropteridine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15104:SF0">
        <property type="entry name" value="DIHYDROPTERIDINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="RefSeq" id="XP_022080564.1"/>
        </source>
    </evidence>
    <sequence length="266" mass="28044" checksum="2DCB33AA932C125F" modified="2022-01-19" version="1">MQRVQGDDVTSHFSLHAGFPERDFTKMAATSGSRVLVYGGKGALGTVIVNYFKSKGWWVCSMDLVPNEEAQVNLVVDPAQSWTEQEVSIMGKVEETLSGEKLDAILCVAGGWAGGNAASKALVKNADLMCKQSVWTSVISAGLAARYLKEGGLLQLTGAKAALDGGTPGMIAYGMAKATVHHLVRSLGMPGSGIPANATALAICPVTLDTPMNRKNMPSADFSAWTPLEFVASLLFDWAVGSQPRPTSGSLVQLITKEGKTELVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIH5</accession>
    <name>A0A8B7XIH5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Testicular haploid expressed gene protein-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC110973802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080604.1">
        <property type="nucleotide sequence ID" value="XM_022224912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIH5"/>
    <dbReference type="GeneID" id="110973802"/>
    <dbReference type="KEGG" id="aplc:110973802"/>
    <dbReference type="OrthoDB" id="25466at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042401">
        <property type="entry name" value="SPMAP2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006623">
        <property type="entry name" value="THEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15901">
        <property type="entry name" value="TESTICULAR HAPLOID EXPRESSED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15901:SF15">
        <property type="entry name" value="TESTICULAR HAPLOID EXPRESSED GENE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14912">
        <property type="entry name" value="THEG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00705">
        <property type="entry name" value="THEG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_022080604.1"/>
        </source>
    </evidence>
    <sequence length="318" mass="35604" checksum="BD30250060BA5652" modified="2022-01-19" version="1">MATMAEVQLIEDTSGNPYQDLRGRERCVYLATPKTSKAVWLTSLGPKLVWGNQETILPISKAAMQAEPSPRVHQLAVPKKNFRSLSDGIKRIHVYSCGRNSVIWDVSPLAMQAEATPRVMELSRFKMPPPAYREDRINHALSCGRESPIWQVSAAAKRARDKHSLEALARPKTPHRDYQPPREVETVVSDNAKKAVASPRLESLARPKSRPDGPFRDAKWPVSDLARNATATPRQLELAKPKGLVDGYQPERTVQWEVTRAARRTVATARTVDLSRPIMRATMDHVQFNPDAFIVSEAAKKGRCPPRIEELAQPITRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XIK5</accession>
    <name>A0A8B7XIK5_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein LOC110973819</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC110973819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022080633.1">
        <property type="nucleotide sequence ID" value="XM_022224941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XIK5"/>
    <dbReference type="GeneID" id="110973819"/>
    <dbReference type="KEGG" id="aplc:110973819"/>
    <dbReference type="OMA" id="HIELIWR"/>
    <dbReference type="OrthoDB" id="9994358at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034876067" evidence="1">
        <location>
            <begin position="24"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="RefSeq" id="XP_022080633.1"/>
        </source>
    </evidence>
    <sequence length="713" mass="80250" checksum="F763C10888B373CF" modified="2022-01-19" version="1">MSFNGMWILCTLVLFAQLSRALGAFGDDISQDNEDNRFAVMGQVTKDIFDVQSGNVTLQLNVQDTTGTMEFWLLDFQEYRFNLDALPVDEVTGNLLKDRTSACSNVYEDADWDTFFNDSYIQDKGDSSLTSKNLFTTIKRGDIDTDGIMRNDKIIFQGDMATFANCKDSNDEEYVWEMTAITSDEIEYRTKLYATNIRPKDPEDPTGGVSFVQSHIELIWRISRSVLAKFLISSTALIKPVLEFARVSAVYDEQNRVVPTQSALHIRFRTIVDANDQMVNYENNSITYLPENVNHALNTIVYQPVGILDEAPACDFVLDEGTRTQMQCQQAWEFKMILDIDTSTQVDNRVPIDASGTFEFLYMAYRCGLENNTLNVSSCIAMSVDPAKISALITIQTTVFVQDEEEDQVIIILHSLTGASNEDLSYGTGSRGVAHKEYVDLRVKFSPAFLRKDYDLFLLLFMVCKGQEYASHQYLQGCLQAPSEDRYVAHYDATFNFIPRITDDNGTVVILNAYNTTHVENDVQQPLHIQEYLREESGETLAIPVHRSTFYNLALSAESDVYTITVVYRLIDTQGRKRRAALPHMQDIILAKSVVGRAGVGRTTGTIITRHARDVVDSVQASHSNRIPFLSLGCPEEATHVQEELDCKCPAGMVYSSNSFNCEALSLNEDVKEVKEDDQVNDLKETAHAQCIACPISLILLANSLLFLLLKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XMP0</accession>
    <name>A0A8B7XMP0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC110974150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="RefSeq" id="XP_022081245.1">
        <property type="nucleotide sequence ID" value="XM_022225553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XMP0"/>
    <dbReference type="GeneID" id="110974150"/>
    <dbReference type="KEGG" id="aplc:110974150"/>
    <dbReference type="CTD" id="79087"/>
    <dbReference type="OMA" id="WWVEVRM"/>
    <dbReference type="OrthoDB" id="19039at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_022081245.1"/>
        </source>
    </evidence>
    <sequence length="540" mass="60698" checksum="4D18FA6AAE43FAA9" modified="2022-01-19" version="1">MKRHVGHAETAPSSTPAPKSVAMAEMKKKKKRVSWSDDRGGFLSSSLDKEDVFEDGSIGPLLSLLLLVIPMIHLYVCPFTKVEESFNVQAMHDILYHRSNISAYDHLEFPGVVPRTFLGPVVVSALSYPFVTAASMLGASTFVSQYIVRACLGLLVIHSFRDFCEQVTWKFGHSTAKYLVLITLSQFHFMFYMTRPLPNVFALAIALRAISSWMQRDHRDFILLSAFAILAFRFELCLLLGLMLLEELLSRRLGLVSLLGWGTVGGVLSLGATVLTDSFFWQYWLWPEGAVLWYNTVLNKSSNWGTSPFMWYFYSAIPRAMAASLMLVPVGCFVDRRVWRFLLPPMGFVFLYSFLPHKELRFIIYVFPMLNTAAAVAISYIFRHFSKSVFMKLLAVGVIGHFLVNMAATLAFLVVSHHNYPGGVALTKLHDAVPQDTAHVHVHIDVATAQTGVTRFTQVNRHWIYNKTENLPPGGPDVMAFTHLCVGASSRPDVSSAVRPYRSTHNIVAVVQGFSGISLRESPYIKMEPKIYVLEKRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNH0</accession>
    <name>A0A8B7XNH0_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC110974795</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082368.1">
        <property type="nucleotide sequence ID" value="XM_022226676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNH0"/>
    <dbReference type="GeneID" id="110974795"/>
    <dbReference type="KEGG" id="aplc:110974795"/>
    <dbReference type="CTD" id="64785"/>
    <dbReference type="OMA" id="IYKEGWR"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="88"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="RefSeq" id="XP_022082368.1"/>
        </source>
    </evidence>
    <sequence length="212" mass="24342" checksum="4645FFD7F8A6ACF8" modified="2022-01-19" version="1">MASTSEIYTRFSSSSDNYYNIEDILASQEKVPVKTELPLYNLGFLNPSSDSEHILPGSKMELPFWLATGLCSRKRKIVSVELPKAYRVGYREIFTADPNVVDLHKTGPYFYSFGTKLLCFESNESDDISRSLLQTFVGRFRRIMDNSQNALNEDITKLMAKLDEMERSLFRAGQKSLMAFQEWETRKMTKLAASGMVTSHRKRKRAMMEEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNP2</accession>
    <name>A0A8B7XNP2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 23 24 25" type="primary">LOC110974840</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23 24" key="1">
        <citation type="submission" date="2025-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022082434.1">
        <property type="nucleotide sequence ID" value="XM_022226742.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082436.1">
        <property type="nucleotide sequence ID" value="XM_022226744.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082437.1">
        <property type="nucleotide sequence ID" value="XM_022226745.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_022082439.1">
        <property type="nucleotide sequence ID" value="XM_022226747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNP2"/>
    <dbReference type="GeneID" id="110974840"/>
    <dbReference type="KEGG" id="aplc:110974840"/>
    <dbReference type="OMA" id="LYMFVNI"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="RefSeq" id="XP_022082434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_022082436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_022082437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="RefSeq" id="XP_022082439.1"/>
        </source>
    </evidence>
    <sequence length="515" mass="56458" checksum="B7F001FC4EE75436" modified="2022-01-19" version="1">MTEVREREGRRGEYSLEPKKNGGTEALEKKAPLDGDGVSVGDGKGVKLKRQVGLISGIALIVGTMIGSGIFVSPKGVLTQTDSVGMSLVVWLLCGILATMGALCYAELGTVVPKSGAEYAYLWTLGPVPAYLFAWTSTIVIKPSSLSIIALAFGAYVAEPFFSGECGPPQIAIKMFAALAILLIVFINCASVKWATSVQNFFTAAKILALIIIIVVGFVKLIQGEVRYLSPSVSFTGSSTNVFAYGIAFYQGLWAYDGWNQLNYITEELVKPYRNLPLAIIIGIPLVTILYLLVNIAYFTVMSPEELLQSGAVAVTLAERSLGPMAWVIPFFVCCSTFGAANGSLFTSGRLTFVAAREGHMVEILSMVHVKRYTPFPALAFQSFIALLMLLPGDFETLVNYFSFAAWLFYGGTVAALLVLRYRHPEWHRPIKVPIVIPIIVLIASVYLVIAPIIDEPALEYLFAFLFILAGLIFYVPFVHYKYELPFMKHITVFFQLLLEVAPTSYFETEELQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XNR9</accession>
    <name>A0A8B7XNR9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 2U1-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110974401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_022081701.1">
        <property type="nucleotide sequence ID" value="XM_022226009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XNR9"/>
    <dbReference type="GeneID" id="110974401"/>
    <dbReference type="KEGG" id="aplc:110974401"/>
    <dbReference type="OMA" id="TCAFLME"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000036">
        <property type="entry name" value="CYtochrome P450 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF417">
        <property type="entry name" value="CYTOCHROME P450 508B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_022081701.1"/>
        </source>
    </evidence>
    <sequence length="497" mass="57356" checksum="AB0091DB4191AE86" modified="2022-01-19" version="1">MDTAVEAILPSFIESRHVVTLVVAVLVFLLVYLIKPKNLPPGPLGWPLLGYLPGLFPDPLVSFSKLADKYGKILSIRMGPQLVVMLSDYETLHKAYVKMADEFSDNMIMSWVLESKRDVGSLFWENGERWRQRRRFSVKTLRGFGFGKRSLEARIHEEGRFFCREMERLNGQPVVLNSLLFNASSNIICAISLGTRYDYHDKAFEEQLAIMTELIEGVRLLEPANIIPPLWHTRWYKRRRGMFKAHEDFIREHLKYHKATLDPDNIRDMMDAYLVEMQRRIDTNDPIQHTEEGIVHSISDLFGAGTGTLSNTTLWIIIYMLRHPEIQKKIQEEVDRAVGADGVPSTTQREEMPFTCAFLMEIQRLRPLAAIIFRHLRVPVKLCGYNIPKDTPVFGNVFYIQNSPKFWDDPLECRPERFLSADGKTLVPRKDWIPFGLGRRMCLGEALTKMELFIFTVTVMQRFTFKVPDGDPLPPLDLPDGGLVMYAPKFRVCCVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQG2</accession>
    <name>A0A8B7XQG2_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC110975166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="10">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.1.3.-" evidence="10"/>
    <dbReference type="RefSeq" id="XP_022083064.1">
        <property type="nucleotide sequence ID" value="XM_022227372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQG2"/>
    <dbReference type="GeneID" id="110975166"/>
    <dbReference type="KEGG" id="aplc:110975166"/>
    <dbReference type="CTD" id="73419"/>
    <dbReference type="OMA" id="IFARQKM"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051998">
        <property type="term" value="F:protein carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10880:FF:000005">
        <property type="entry name" value="DUF89-domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000001">
        <property type="entry name" value="protein-glutamate O-methyltransferase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="11">
        <location>
            <begin position="31"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_022083064.1"/>
        </source>
    </evidence>
    <sequence length="448" mass="51478" checksum="3B71337B5D6CEDF6" modified="2022-01-19" version="1">MPQFEMTSTKCSDTLPPRLSAKYEGSFAYFTIRDRLPVILTKVIDTLYTYRIKAAQQYGEEGAADCKSIVSSLAKFRNELQTDKPVLPLESNEGADSQIWQRYLEEETQRNGGRPPSWFQSPWLYVECYMYRRIVESIRLSKHLKSFDPFRELKDTALETSQDALVILAKYLQSTSEENGKAVDLFTEFVQISLWGNKCDLSISAGIENSQKISPLSQLKELRDKILVDDTEKLWHVLEKARERKAENGKVRLDIVLDNAGFELFTDLCLAEFALHTNAVDTVVLHYKAMPWFVSDVGRNDFMHTLNFLEHHENKVLQNLSKTWTERLQTGSWILQGHLFWTTPHDYSEMRSVSPELYSELSNSDLVLLKGDLNYRKLVGDRQWEHTVPYAETLCGFHPAPHCALRTNKADVIVGLEEGVTEQIEAVDKDWMIDGKYAVIQFCGVIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQJ9</accession>
    <name>A0A8B7XQJ9_ACAPL</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mucin-17-like isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC110974758</name>
    </gene>
    <organism evidence="10 11">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
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    </evidence>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="RefSeq" id="XP_022082301.1"/>
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    <sequence length="4317" mass="453075" checksum="82FEC089ECF7C847" modified="2022-01-19" version="1">[encoded data, 4317 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XQM6</accession>
    <name>A0A8B7XQM6_ACAPL</name>
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        <submittedName>
            <fullName evidence="6">POTE ankyrin domain family member A-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC110975196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="RefSeq" id="XP_022083134.1">
        <property type="nucleotide sequence ID" value="XM_022227442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XQM6"/>
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        <property type="component" value="Unplaced"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="271"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="320"/>
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    </feature>
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            <begin position="508"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="278"/>
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            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="RefSeq" id="XP_022083134.1"/>
        </source>
    </evidence>
    <sequence length="556" mass="60496" checksum="0A6CCEA72A05CD21" modified="2022-01-19" version="1">MIHIPSVRDRSRRTSLGQVSGGVAIHDAVVKGKIHLAKFILDAVESHTVVNSRDAHGKTPLIRAVRIEDEGVRGRVVDLLVKYHADVNLVDNVGRSALSYACELHRSDVIKKLVKNNVDPNLPDKNGNSPLMYCAETGNAAGIEILSKSFRRLGLDVDTVNADGMTPLMVAAKSGYVECAQLLAHEAKASLSRRDNVHNMNAIDWAREGGCSTPDLEALQARSRSHSKSAVNLSDSDQAAGRTQGNVSNPERMLPKRGTVVPNPIASNLGSTASLPHIESDGVKEPSAKFTGSQPDIRHVQNDKRRFHQMSLGELSQRFQGLSAGSSPEHYKENISSPDTPTKTATVRRWCSEESSSSDSQRQLSIDGIVDDLKSSEKMAPPNEPAQPRPSTAVGVFNKRVQHVGDHRRRPLSANVANRHTNRQTKSFDSALSLTNSRPSNSVENLSLTVTQPLVVPHPPNTARTGSNLSRLSHLSKSTEIISNRRPSLEQHNDSNSASIRYMDLQEISGSSKRERQASLSPGDLSGLLMRPDTATSGQDFEHLPSISLKCTSREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XR02</accession>
    <name>A0A8B7XR02_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="11">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC110975254</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="11"/>
    <dbReference type="RefSeq" id="XP_022083273.1">
        <property type="nucleotide sequence ID" value="XM_022227581.1"/>
    </dbReference>
    <dbReference type="GeneID" id="110975254"/>
    <dbReference type="KEGG" id="aplc:110975254"/>
    <dbReference type="CTD" id="54617"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001304">
        <property type="entry name" value="DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000006">
        <property type="entry name" value="Putative DNA helicase INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020838">
        <property type="entry name" value="DBINO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13892">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51413">
        <property type="entry name" value="DBINO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBINO" evidence="15">
        <location>
            <begin position="292"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="536"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1199"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="202"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1373"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1448"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1566"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1373"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1397"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1452"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1608"/>
            <end position="1622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51413"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="RefSeq" id="XP_022083273.1"/>
        </source>
    </evidence>
    <sequence length="1622" mass="183809" checksum="E9B9FE8D0D52DE89" modified="2022-01-19" version="1">MSEGSKGVSSDAVLPEGPVGGVPQAKPLHIQRLEKAVCLEPYLAYVEKILTASTPEHGEEELYKEEVGRDAVPPDDEALKEDDNRDKDVKTVHGLITSRAERKADRRRLYNLSKVKKSRRWLKNILLSDSSDSSAVEEEDEDKPLSQEELKEMIQLHRYKRQCQSKFYTEGELQQYQYYSTGLLSSYDNFLDHKKLVLGPKQNKEKQIKKEKVSPTQSVPIMPEEQPETEKLKKVNPKPKKKVEAKEKPDIQVQATPPALVSASTSVAHFQDALNHKKLMAIKDVEARRRRVWHAIIRKDIPKAQKHRMSVHNNILTNARKLAQACQKEQRRRAIASQRVCKETPHRARRMTREMTAYWRHYDKVEKEHRKKAEKEAQEQRRLDDEMREARRQQRKLNFLITQTELYAHFMSRKLTGEGEEQKERILSRLEDHLPKRQVAIQGGVLVDVEEDDYDCDFMKQQALSNVSFAYTTHQEKQRVFDGDRTMPDTSVSQQAFDKDFSLSNPAMLLESERAQPAMFRGQLKSYQLKGMNWLANLYDCSINGILADEMGLGKTVQSIGFLAHLAESQGIWGPFLIVAPASTLHNWQQECARFVPGFKVLPYWGNPQERRILRKFWSQRPLQTTDSEFHILITSYQLVIQDIKYFQRIKWHYMILDEAQAIKSSSSVRWKLLLQFSCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAERQSGINEEQLSRLHMILKPFMLRRVKKDVENELSDKIEILVYCHLTTRQRLFYQALRNKISIEDLLQSSSSSAASSTTSQSQSTANSLMNLVMQFRKVCNHPELFERRDTRSPFYCQLDPPVHFVPRLIYQDGMVDRLDPTRNKLLRSTFSVFAPDYIHASLSPSTSRQARSSCFSFARFVDLSPAQLHGQLVMGLMARWLALFLVMKSAYRVHHACQWGADKDHARYLGRHGLILWPRWTTSPPSVASSPALRDLVFTGNTSGVVAHPTQTYYFMPETPWHRRVRLSKAGQPDADGESVNGDSGTPDRSSSWSPRSSSSPRSPRSPRSPAAAKRVRQGGSSHSVGSLLSASGHFLPIMSDRPSAVRVCSPTELPAFICHYMPKVLAPPLGHYCSHRQAEYDHRREELGGSLDAWLCALHGSPDCYQDVQRGLLFPLPRAGLSAVRPHHGWSKIQIPDKQYLVTDSGKMYVLDELLTRLKREGHRVLIYSQMTRMIDLLEEFMWHRKHTYMRLDGSSKISDRRDMVADFQSRSDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEEKILQRAREKSEIQRMVITGGQFKPEQLKPKEVVSLLLDDEEIERKFHEQQREKKLTEERNRARDRKRKREKYAEMKKEAGKKLKADGVPGTPLGSLVSDGASVSLDGEDSLLSMDSGAPSPLSVVSVGSETQRQAQSYTPVSVDENSNDGLVIADEQSADIELDDSARSHQPGSGKRGPSRGGKTTPSPGTKRIQARPGRVRKGTGAAAIAGARAGAVAGTAAAYAAYGFSFKEKSNSALAMPGDTVGTTVSPHRNSNPSPSPVPSQDPQDVKAPTGPSPVPSTSSSVSSHQSPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XRF7</accession>
    <name>A0A8B7XRF7_ACAPL</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase beta</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC110975335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Acanthaster planci</name>
        <name type="common">Crown-of-thorns starfish</name>
        <dbReference type="NCBI Taxonomy" id="133434"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Echinodermata</taxon>
            <taxon>Eleutherozoa</taxon>
            <taxon>Asterozoa</taxon>
            <taxon>Asteroidea</taxon>
            <taxon>Valvatacea</taxon>
            <taxon>Valvatida</taxon>
            <taxon>Acanthasteridae</taxon>
            <taxon>Acanthaster</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19878"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Rough endoplasmic reticulum membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="RefSeq" id="XP_022083428.1">
        <property type="nucleotide sequence ID" value="XM_022227736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XRF7"/>
    <dbReference type="GeneID" id="110975335"/>
    <dbReference type="KEGG" id="aplc:110975335"/>
    <dbReference type="CTD" id="5298"/>
    <dbReference type="OMA" id="HKLANCN"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000694845">
        <property type="component" value="Unplaced"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbRefe
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